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<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Y8</accession>
    <name>A0A401G4Y8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027752324.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A401G4Y8"/>
    <dbReference type="STRING" id="139825.A0A401G4Y8"/>
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    <dbReference type="InParanoid" id="A0A401G4Y8"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="475"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="124"/>
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            <end position="160"/>
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            <end position="215"/>
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            <end position="249"/>
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        <location>
            <begin position="289"/>
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            <end position="321"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="448"/>
            <end position="468"/>
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        <location>
            <begin position="521"/>
            <end position="533"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="562"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="586" mass="62155" checksum="72BF2CDEB10C087F" modified="2019-05-08" version="1">MESHYKPKVTSKLEYDRVRPVSPSKLQQPQLGPSPSLPIARPKAKVTSSATVISRRTNSSTRPPSALPSPRAPSPFKQDHAPHASVVFPVKARLTTNVRANGIRSASPGTDSRQHALTTVSTETQPRRKARNGSISSHVSHIPSPANSTAPSPSHSPTSSRVGVSSEENGSPHAGVTLGVVRVKSKISRLTEPGLPSSPSSPPLAHRSARPASASNISLSPPLPPANGYSGTPSHAHQRFATTRESASQRVHAFQPFPANDDLVVKYGGYTVPTKLDPAEIPLPPQSPPMSTLSFSSRSSASRSSVSCETQATDTSRNTAPASALKEPTCGAVSTSSQAVFLAAAASTPSPSEGGFDDDDVDDHVPSANSEDIDPDRKMKAEAKSNRKIADLEITTRSLLAINLSLEATKHRQAKEIRDLKRKLRESRLILPPPAYHAVKSSLTHDDTAEDDVETGTDAGSEDEDEQALLEGHDDEPYRRVKVILDSLLDECARALASTPADFAEGGRSGAKVLSADEVRSWRGDDTETRSLADRSALGEPSLPSRIAVPDSDDDMGSESEVEASLLESDSRATSPLPPITVTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5A1</accession>
    <name>A0A401G5A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0102100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608250.1">
        <property type="nucleotide sequence ID" value="XM_027752449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5A1"/>
    <dbReference type="STRING" id="139825.A0A401G5A1"/>
    <dbReference type="GeneID" id="38774254"/>
    <dbReference type="InParanoid" id="A0A401G5A1"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="489" mass="54029" checksum="CB1255B3CE588D14" modified="2019-05-08" version="1">MKDFISRFGQIDSDGQPYLSSSRQSIITSLLSAGTFIGALAQAYTSDRFGRRGSILIWSGIFTVGTVIQTSTIHSIAQITVGRFIAGLGVGALSAIVPLYNGETAPKAMRGMLLVLYQMQIIIGIFISYVIDLGTHHLNGPASWRIPVGLQMLWGFILLSGIFFLPESPRHLLGQGREEEARKVIAELNSVEVDDPVVLETIEDLEYGIKAENEGGKATWLECFSTRNMLWKRTINGMMLQFIQQLNGQNFYYYYGDTFFSSAGTSLSPYAIQTILGGVSVAGTIPALYLIETWGRRRSLLTGALLEAPCAIIAALAGHFMLAKTGTPDSQLTSRNRTGGDVLIAFGILQVFAYSLFWGPTPWVYLGESFPLRVRSKCIALGSATNWIWNFLLSFFAPRIASDIGPLILLIFFGMLLFGFVYVYLFIPETKGLSLEEVDELYRANVAPWQSAGWRPTEKHLHDKAPEATEVREVREKTEKGEVIDGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5H7</accession>
    <name>A0A401G5H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease Le2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0102910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608331.1">
        <property type="nucleotide sequence ID" value="XM_027752530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5H7"/>
    <dbReference type="GeneID" id="38774335"/>
    <dbReference type="InParanoid" id="A0A401G5H7"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019223899" evidence="4">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="242" mass="26316" checksum="582FDFF85161B745" modified="2019-05-08" version="1">MFQYVYVPLAVVALACTAFAAQAEAPLSLATTSLSSGCGTNLTPSCQNSSVETNSCCFEAPGGWISQVQFWDTNPSTGPSTNWTIHGLWPNNCDGSYSEDCDPSRDYSDITSLLQDQGASSTLDFMQTYWISDDESNEAFWEAVAFFETAVNLFQSLPTYEWLEQAGITPGDSEYALSDLVSALQSAFGATPIFSCNDHNTIYQISYYFNLQGSMIDGQFDPVDAPSSSSCDSQVMYPAKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5U8</accession>
    <name>A0A401G5U8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 14">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0104130</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 14"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608451.1">
        <property type="nucleotide sequence ID" value="XM_027752650.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G5U8">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5U8"/>
    <dbReference type="GeneID" id="38774455"/>
    <dbReference type="InParanoid" id="A0A401G5U8"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 14" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="751"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="17">
        <location>
            <begin position="1117"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="235"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="477"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="13">
        <location>
            <begin position="1121"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="13">
        <location>
            <begin position="1148"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="13">
        <location>
            <begin position="1268"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="1150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE77538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1422" mass="155812" checksum="621262E471438ABE" modified="2019-05-08" version="1">MSTTDGNATSGSGRHPLILLLSAFFWVILWLLSWVKALIGFATITIPKCIYAILSYSMTLTLNFWSFALIFALSAVVLNYWIRFRYLNTYTKLKEPPLVKADAQELHPDVNTPEQAPAFHNYLDEFLQAVRVFGFLEKPVFHELARHLQTRRLIAGDSLSLDQDKSFYCVIDGSVQVYARTGQPRHENSRGSWDNEDMNGYQLLNQVGPGGTLSSLFTILSLFTENVQMSWQDGEKADEELESVGSPPSAPPRSRTHRSDSDVSNLDLTGATPSNIGSRERRQSVSSGGSTVHPVDVSSPGERSRSGDPGLAGVSAATFPSLPRPHMNASASTTDTESHYGVVARATEDSTLAVIPAEAFRRLTKKFPKSTAHIVQVILTRFSRVTFNAAHNYLGLTTEVLRTEKAINDIACHPLPPSFYESGLKHLRQRFDGVGLSSDSDTESDFFSYASSSANSSRVSLTASNKVQDSLAPTYWAPTTPSRTPASHSQVQAGDLHTSTGNTGDIYTPLTRRNTVTLRHDPLTVSRQGNAHGGKRVHSDDFDLRDEVMSCIAKSIGLIQPPLSGDDSVEASPAFPASEAGRSQSGLFKSSFGSLSLLEMGDDTSSVTGSSSIVTDGNMSGLDNEVEILFFPAGSVLAKAGDRNTGLFYVIEGYLDMLLPSEGSTEHNDAKLRATPDTGLAHLDGRKDQTQKPLFSVKPGGIAGYLSSLCQTASYVDIVAKIDTYVGFLPSHALERLLEKRPIVLLTLAKRLISLLSPLVLHIDGSLDWVQVNAGQVLWRPNDVSDSFYIVINGRLRAITDKDGGGINILAEYGQGDTVGELDAITSSLRRNTVHAIRDTELIRMPRTLFNAISSRNPRTTAQLLKMIASRVRVELDSSSRTLPSDVSRNINLKNVAVLPVSRNVPIDAFARKLHTALESIGAPTFYLNQASVSDHLGRHAFTRMGKLKAAGWLAEQEQKYRIVLYVADSPVNSSWTQTCIRQADCVMVVGMGDDPSIGEYERLLLSMKTTARKELVLLHPDRSVVPGSTREWLKNRTWVHQHMHVELPGIISSVTRNASEPQDPAALAAFKNLKDRVQSGIQKYRGGVSLARPQRPPYASDFARLARRICGKSIGVVLGGGGARGISHLGVLRALEEQGIPIDHIGGTSIGAFVAGLYAREGDLISTAGRAKQFSGRMANIWRMLSDVTYPLVAYTTGHEFNRSIYKAFYDLHIEDMWLPYFCNSTNINTSRMEIHDTGYAWRFIRASMTLVGMLPPLCDNGNMLVDGGYIDNLPVSTMMAMGASAVIASDVGSIDDNSPRSFGDSVSGWWLLINRWNPFSNARYIPAITEIQSRLAYVSSVKTLEDAKVAQGCLYMQMPVQEFGTLQFGRFEEMQKKGYDAAMDMLEKWDEEGRLPSAFITGPAIATGKRRGKSARRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G707</accession>
    <name>A0A401G707_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable xyloglucan-specific endo-beta-1,4-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0108260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608857.1">
        <property type="nucleotide sequence ID" value="XM_027753056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G707"/>
    <dbReference type="STRING" id="139825.A0A401G707"/>
    <dbReference type="GeneID" id="38774861"/>
    <dbReference type="InParanoid" id="A0A401G707"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019428811" evidence="3">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="26289" checksum="792395B4FE58E29C" modified="2019-05-08" version="1">MFLSLAFVSGLIALVKGQTTITAQYACVTSGNYELCNNQWGIDDGTGSQNATLISTSGNDISWSTTWTWADNENDVKTYTNVESTTAKGMLLSAITSAPTSWDWEYVTESSGIRADVSYDIWFGTTADGAQASSDSSYEIMIWLSGLGGIQPVGSENQTDVSLAGYSWDIWSGPNSNWETISFVSQDGNINDFSEDLNTFFTYLIDNYGVSSSLYLQGIETGTEPFTGSAELLTNSYSVTVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G762</accession>
    <name>A0A401G762_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 SUMO-protein ligase pli1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0108880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608919.1">
        <property type="nucleotide sequence ID" value="XM_027753118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G762"/>
    <dbReference type="FunCoup" id="A0A401G762">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G762"/>
    <dbReference type="GeneID" id="38774923"/>
    <dbReference type="InParanoid" id="A0A401G762"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="142"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="338"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="74306" checksum="4454A22B5177E95E" modified="2019-05-08" version="1">MATSWDDFETSRHNVKLNTVDRLKQILTGFNEECQTNLTKSGKKQELIERITRELDQWRRTNNIDKWAKARVILNQVRTIGMYSPTRMSGEHSFTTSVPPHKTYPAASSVGHGYQSSVSGSSSSLPRYDPYAPARIPTATHPSTSTVHPPTPSIRFKPSPFFRVERAVSSVVECPESTSALDRRQQSIVFTMPNDVVMKLNSSNPTYQLRLYCTSSTYYMPSSAFRTTSGPCPIEFPPTCEVRVNGVPLTANLKGMKKKPGTAPPPDLGKSLRTSSGASNRIEMVYVNSQQPVLSKKYYLVVMLVETTTVDQLIERLKKGKYKSSHDIVTKMAQSAATDDDIVAGQQKMSLKCPLSYMRIVTPCRSSLCVHSQCFDALSWFSLMEQTTTWLCPVCEKVLNPEDLIVDGYFDEILKQTPESVEDVLVESDGQWHSSDNKCGSAEWKAAHSPAKVLAALHPAPAVKRADTPVKVVPNGVNGEAKSGPSNAEIVILDSDDEDEGRVKRELSPSYDGAPGSSNVSQASLPPRSQSQSTDVIDLTLDSEDEDSPTTLSRKRKTVEIDLPSPTEQIWKKSRSEASVPASTHTAGSSHSSYLQSPHFPASRELASRSLSGAIPTSSSSYQPSYPGTGGAQYLPMALPPRRPPGTVHNEHYSDITNPYMPRINGGGSASPNSWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8F4</accession>
    <name>A0A401G8F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peroxisomal long-chain fatty acid import protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0113010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609326.1">
        <property type="nucleotide sequence ID" value="XM_027753525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8F4"/>
    <dbReference type="STRING" id="139825.A0A401G8F4"/>
    <dbReference type="GeneID" id="38775330"/>
    <dbReference type="InParanoid" id="A0A401G8F4"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000636">
        <property type="entry name" value="ATP-binding cassette sub-family D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="461"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="711" mass="80164" checksum="C247CCE4BA75EF07" modified="2019-05-08" version="1">MAVQSTLRNSRQHLKQLANFYVAHRPVFQRLLTIAFAVHVISSTYHGFSAKSSPKSKGKEKEKVEAVNQGHPRRPVRVAVDALFYQRLSTILRIVIPNLRSKEALLLCMHSSLLIFRTVISLYVAALDGKIVASLVRAQPVPFLFNILRWLLVAIPATWTNSWLSYVQSKLALAYRTRLTEEAMKQYFGDEHTQNLNVFYKLSNLDDRIKNPDQMITHDIQRFSAHLAAIYANVAKPVLDVILYNYQLSQNVGAEGLVLLTVFVQLSATLLRKLTPPFGLFTALSAQLSGNLRHTQSRLAEFSEEIAFYGGEETEKMLVEREYAGLVKHESRVLRSRWWHGCVEEGIIKWLWGSFGLCICAIPIFFRIPGVNNVDLGGRTEGFVTNRRLLLSASDAFGRVMYSYKDLSELAGYTTRVALLLETMAEIRKGKFEKALVSSASVEEHAKVLKGRGVVVESDDIEFEDVPVVTPNGDILVRSLSFYVKPGRHLLIVGPNGCGKSSLFRILAGLWPVYGGIVRKPPASQFILIPQRPYLSLGTLRDQVIYPHGRDEMEARSVTDDDLLAILSVVQMDHVVERDGGWDAAREWRETLSGGDQQKIAWARLFYHKPKYAVLDEATSLVPVEMEGKMMEYAARLGITLLTVSHRPSLWKYHAMILQFDGQGGYVFTNLDAEKRLALQQEKETLEGKLLEVPKMKARLAELRAVPLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8Q8</accession>
    <name>A0A401G8Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0114490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609473.1">
        <property type="nucleotide sequence ID" value="XM_027753672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8Q8"/>
    <dbReference type="GeneID" id="38775477"/>
    <dbReference type="InParanoid" id="A0A401G8Q8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10157" checksum="6E556A2A872065FF" modified="2019-05-08" version="1">MRHPPPPPGLPPALPCPLLSDMQDAQHEDMREHLNEAPASNTGASFVLIVARRDATPTTSSWPSPGSPPSSAVQRAGCPASSPDVTPTNGHSPMDTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G978</accession>
    <name>A0A401G978_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0116150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609637.1">
        <property type="nucleotide sequence ID" value="XM_027753836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G978"/>
    <dbReference type="GeneID" id="38775641"/>
    <dbReference type="InParanoid" id="A0A401G978"/>
    <dbReference type="OrthoDB" id="5514856at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8024" checksum="F82C4BC665DACCA2" modified="2019-05-08" version="1">MARRSAPPGSGPAYYSGAPSRRAIGDPNESAFSQFLREEIWAPEKLPGNVSILTGIAVFFGGIAAIRTFGDLMIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9M3</accession>
    <name>A0A401G9M3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ subfamily C member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0200710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609787.1">
        <property type="nucleotide sequence ID" value="XM_027753986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9M3"/>
    <dbReference type="STRING" id="139825.A0A401G9M3"/>
    <dbReference type="GeneID" id="38775791"/>
    <dbReference type="InParanoid" id="A0A401G9M3"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019289874" evidence="6">
        <location>
            <begin position="23"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="434"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="544" mass="59659" checksum="DBE5113F647A0157" modified="2019-05-08" version="1">MFIRISSLVSSVLAVLLYGVNADPNPSSGTSGSALYPPGLTPLINRANALLTAGQFNDAAKAYSEAIELSPADYLLYYKRATAYYSLSRHPAALADFDQVLSLTSNAFDNAYLMKARIYAKDGNFAQARDSIKKYTAKVKDTSAQEVLFSISEAELAAKKAGQAMRAKLWTACVEAASTALQTASHSIELRQQRADCAVAAGDIEGAVGDLTRLTHLTSPSTQLLMKIFRLSYFLGPYAPSSQAPSPALTTLKQCLHYDPDSAACLPAHRLVKAFEKSLKSLERLLTAEDWRGIVSLLAGVSGKEGFMNQFDAALDTHTTRATLDLPAKVPVPNARRMSPRREALLRALCRAYVKLGEARKGERYCEALLEMDGLKEDADGLMCRAEVLMIEEEWEEAVRVLERAFEASGRTNREIHQKLQKAQKLLKQSRHKDYYKILGVARDADTKTIKKAYRKAAMTAHPDKGGSEAKMASVNEAYEVLSDPELRQRFDNGDDPNDPMSQQGGHPFSSGPGAQQFAQFFQQGFPSGFQFHFSPPGFHGQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA48</accession>
    <name>A0A401GA48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD-domain/PDEase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0202370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609953.1">
        <property type="nucleotide sequence ID" value="XM_027754152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA48"/>
    <dbReference type="STRING" id="139825.A0A401GA48"/>
    <dbReference type="GeneID" id="38775957"/>
    <dbReference type="InParanoid" id="A0A401GA48"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="591" mass="67732" checksum="69D13599E77BEE48" modified="2019-05-08" version="1">MRLMEPEDYSLPPITAPSSPKFTRRFKDCIHDYMPFNRKICHIIDTPQFQRLRNIKQLGTSYHVWPTASHNRFEHSLGVAYLSMILAQHLQQSQPELRITQRDIDCVTIAGLCHDLGHGPWSHVWDGQFIRRALPGATWQHEHASDMMFDALIQGCQMEADKKDVTFIKALIGGDKSMCPLEKQFLFDIVANKRNGLDVDKFDYIARDNHAVDVKGNLSLTRLIHSSRVINDEICYDIKDANQVYELCWTRFSLHKRIYNHKTAKAIEYMLVDALLLADRHLNFSRHIYDPAKFLYLTDHLRTQIESSEEPELAEARAIFFRITTRNLYRMVDYKVFEWSYIDHCRRYFTPERIVDAVKRLPATLLASREVEDLDTEEGEGEGKSEGVGEPIDGDIAALEPRHVIVDLSRMHYGMKDKNPLDSVKFYSKQHPNRSRKAELGDISLLMPQTFGEVLLRVYTRDPRFYGLIQAGYRELLAHSNEEFEEAREDADVLPLSLSPPITEAPSTPRPAQRSMSRVASGARLFGGEEPGTGTSGKTWSNNAFTSVPTNYKLPQSPSAERAQIAARRSSKRKERDGSPPVPTRKSTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAX6</accession>
    <name>A0A401GAX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610237.1">
        <property type="nucleotide sequence ID" value="XM_027754436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAX6"/>
    <dbReference type="STRING" id="139825.A0A401GAX6"/>
    <dbReference type="GeneID" id="38776241"/>
    <dbReference type="InParanoid" id="A0A401GAX6"/>
    <dbReference type="OrthoDB" id="28939at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009563">
        <property type="entry name" value="SSSCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051888">
        <property type="entry name" value="UPF0148_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537:SF1">
        <property type="entry name" value="PROTEIN ZNRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16537">
        <property type="entry name" value="SJOEGREN SYNDROME/SCLERODERMA AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06677">
        <property type="entry name" value="Auto_anti-p27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="316" mass="33384" checksum="E94FAF2D0104BDD0" modified="2019-05-08" version="1">MSTIVDVSGRLGEYMLKGWVLTDNICPKCSKVPLMRSPSSPIISFCANCDAGPPSAAQPQAVDNSGLPGPSLRSSRSGSSSSDQSRSSTPPTEISNAPSSAIFVPPIETEEMLRRRQQSDTASAEIGKRMLRGWAMLADECPNPTCYGIPLVRPPNAGTGRDPRKECVICGTVYVDQKDAFGQDRLVTYNSNSVHDRQPTIIAAPPAPQAATSPVMTRGKATQIPQPQLVRSPPLQVLQPGAAHVATTSTVSALDASADSLVLSLHALSERLNILSGGSIVDPSLIAQTADAISKVSQALTQVKQLQWSEHLAHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAY0</accession>
    <name>A0A401GAY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0204910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610206.1">
        <property type="nucleotide sequence ID" value="XM_027754405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAY0"/>
    <dbReference type="FunCoup" id="A0A401GAY0">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAY0"/>
    <dbReference type="GeneID" id="38776210"/>
    <dbReference type="InParanoid" id="A0A401GAY0"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000003">
        <property type="entry name" value="Mitochondrial ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="147" mass="15683" checksum="7895641266D156BB" modified="2019-05-08" version="1">MSKLAQARAQVVRILVPAGQAAPTPPVGPALGARGVKSMDFCKEFNARTAHIQPGVPTPTLITVRPDRTFTFITKTPPTSYFLKKAAGIEKGTGRPGHETVGTVSLKHIYEIAKIKATDEHLKHLRLEAIASTIIGSARTLGVQVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBH4</accession>
    <name>A0A401GBH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0207150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610428.1">
        <property type="nucleotide sequence ID" value="XM_027754627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBH4"/>
    <dbReference type="STRING" id="139825.A0A401GBH4"/>
    <dbReference type="GeneID" id="38776432"/>
    <dbReference type="InParanoid" id="A0A401GBH4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="853"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="935"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1169" mass="125802" checksum="43788A9C034C0DD2" modified="2019-05-08" version="1">MPLDIDPNYVLQAARLTAIVAAAPRQDDPRYPDWETRIYLEVSRLEKSFPQPLKSLRMPGIVISALLEFTRAYQQKALARLDHISNDDERIYKRYPLAVCEYGECEDLGRQWWTEDPYCKLPPVKSTPAEGWGNVPADDDTQGRGEEDLATGDLITKGKGKERADNDVGTGMVGERIVHVEAGEDKGKGKSKEKAQGKVAHAMSEEEDGGEGEGEGEEQEGEDDDDADSDEDDDADKNDDDEMAEDVPGAGQPESIEVDAASPPPPTARPISISPAAPSLRKCKVVITESSKESENEEAAPKAKRMKPIEVAKEKGEAPTTSGRVQRAQKRMVQTEVEGSKVSTKKSGKRKAKESSDEEEVPTVKPPKKKRATKEYKSKEFIESEDETLAPPSNLPAKTAGDSNDGVAKTNAPAKPVKQTMRMTATPHVAPKAKAKAKAKAKAKAKATGKGKATGKAKAKVMVSQKDMWKKTSTRVSDFMWAHATDSLVPCVGCQEKEWPCKLNTANFGRCLECAARGVSCSIAPRNTDGVPLRGNSHTTQHEFQEMCAALVVEGKPLPTSPPPYDVKVDSDEPDGAEPMFMGALKRKLPKKTKTRNAAASSSKVKGGEEVEATKQKATVTPYEANAEGEASVEKSSKSKRATKSATATGAVALSNSGEVSKSGAVAKPGEGKKSGPKAKPVRSQNSGVQDGGEVTRTSVCEPDEVLPAKSVAKEGGQMTRVAMGGRSGPMVPVITRKAKASAPKAAAKMPLAEGDGMEEAARLAMEAVRAMAFQTGPAAPPQASSSKCMLTPVADEPEDAPEYQAEVAEDERASLERPHDDRRCSLLMPHETSAGAAEVAQEVTPSLEISKALKGVKSSTLAKAGHLDEGRRPAKRGAPLDRKAAKKEAEAKRDAKANRLRAVPPTSKAPHLRDIQRVSTGSPAPVNEGDTPSGEETSQSSNDDCANCAELRQEFLAHKDGMEVQFQERMADLNTVKAEITAALQRINPPSAFQENARSIREEVKLAMEEFRRPVSIELQESVKLAVADLVAKRHCLPELKEKVNRLEQGANQTVSQADVDKLQGELADLRHSMELQAARSDSMEKELRSSAAEAIAQASKLEMELALTKEDSMAVATSALDEAKKVGKEVATAREETSLVAKSLDAFREKVDSAMVFTAFRPDRHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBI7</accession>
    <name>A0A401GBI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0207250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610438.1">
        <property type="nucleotide sequence ID" value="XM_027754637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBI7"/>
    <dbReference type="STRING" id="139825.A0A401GBI7"/>
    <dbReference type="GeneID" id="38776442"/>
    <dbReference type="InParanoid" id="A0A401GBI7"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58493" checksum="0690FD970C53289F" modified="2019-05-08" version="1">MVQRLPLDALNPIVWNSLIQEAMRANRWKLAYQLYVDMKRRGFIPSLRTYTTMFAGYSSIEDWSEKTKQLENVHTLFENYLQRVHTLRDHDPDDPELSVAPLAAYMRILGEAGEIQKMFDVYYAMDDQGPLAPNQFVFTAMFKGLLRRKAITSPAEHGLDARAQNAADAKLIWRRMLRVAGKNPGFKIDSPLINSALTILGLGRASDQLFAFDIVRDHMGLTKPGEEAPQRPLTPQMFMKALWLCHQSQKYRLCIHFFTQLVDRIAAGKEAPILDRRHMEGVLKAYASLAAMGSMTESDQALSTLQWMLREDATRNDAMLKPTLSTFTLVLIACWRGGDWSGAVRTFELMSGYNAEDFRHDITTGSKPRSEKRSKGRNIMPDTVAMSYIARTALATEDVENAQQCLRIIDHIGMDHLLSKTVESESFTDPAVVAFYAAKMAYVVMDLVNATVTAPKSEMSSSPSPEEQRWYDMKTEAKKAVKQNTGLRRAPNLEEDPLGSSRGLAATDSAVEQAFASRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBP0</accession>
    <name>A0A401GBP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0207900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610503.1">
        <property type="nucleotide sequence ID" value="XM_027754702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBP0"/>
    <dbReference type="STRING" id="139825.A0A401GBP0"/>
    <dbReference type="GeneID" id="38776507"/>
    <dbReference type="InParanoid" id="A0A401GBP0"/>
    <dbReference type="OrthoDB" id="3204347at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019458077" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13056" checksum="11A99B5CB3A19A21" modified="2019-05-08" version="1">MLVIFLLSLLGALFVCCLLFPSVRDSITAGDELLDIHEAGLALVSSRTPFRETGPPACMAKLIMLRHKINQDNTRRRCSVSRVRQASRTYHVTPYRPSRDIPWVRFGRAHGKQNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBW5</accession>
    <name>A0A401GBW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutaminase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0208520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610565.1">
        <property type="nucleotide sequence ID" value="XM_027754764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBW5"/>
    <dbReference type="STRING" id="139825.A0A401GBW5"/>
    <dbReference type="GeneID" id="38776569"/>
    <dbReference type="InParanoid" id="A0A401GBW5"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019444036" evidence="1">
        <location>
            <begin position="23"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="349"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="700" mass="75880" checksum="9B705619E5C396E9" modified="2019-05-08" version="1">MAAHSHSFTTLLLLLSSVFVVARPLVRSSDVTWTASPFNPAAVPLAVRSPYLSAWLAQGGGTALNEAWPTFWTGSILGWAGYINVDGVSYNFLGSPAVAGAQKAVQTSFEFTSTQSNFTLTAGPVDLTVSFLSPVEPNDLLKQSLPFSYLALSAAPNDNDVHSVQVYTDISAEWVSGDDSLVVNWTTTAGNIITHQVQLEDQTFFGEVSDHIQQGSAYYSTSNSSGVTYQTGQDIVVRAQFINHSTLTNTQDTNFRAVSDMWPVFAFAHDLGDISGPSESVVFSVGHARDPAVEYLIANDAVQNRSSYFWSAFSTADDAISSFLGDYNAALIRAQALDAQINSDASQISSNYSAVVALSVRQTYGGIEITVSKNSAGQHNTSDVMVFLKEISSDGNVNTVDVIFPAWPLFLYADPIIGKNLLVPLFAYQETGQYPNAFALHDMGSVYPQALGHNDGNDEHMPIEESGNMLIMTLSYAQRTNDNSLITDYYNLLDQWAQYLVTNTLIPGDQVSTDDFAGALANQTNLAIKGIIAIKAMSEMAAIVGNTASSANYSSIASSYVQQWQQLATSSDGQHLTLAYGNDSTWGLSYNMYADKLLNTSLIPSSVYEMQTAWYPTVLNTYGVPLDTRHTYTKSDWQLWTAALVSSTTVRDTFVDSVYKYAADGLNSQPLGDWYETLNGDVDGFRARPVVGGHLALLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBX4</accession>
    <name>A0A401GBX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0208960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610609.1">
        <property type="nucleotide sequence ID" value="XM_027754808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBX4"/>
    <dbReference type="FunCoup" id="A0A401GBX4">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBX4"/>
    <dbReference type="GeneID" id="38776613"/>
    <dbReference type="InParanoid" id="A0A401GBX4"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="469" mass="51794" checksum="E19128807B032FF2" modified="2019-05-08" version="1">MGKHSDPTSWRPRSLNLATANRHLHRLGPDYTPQPRTAVSPSSMSRKSQSVEAVQPEYAEEEVASGAGEGDEVMEDVEEQEEGYSSSTPTSTLTWISWFCSLPGHEYFCEVAEDFIEDDFNLTGLNAMVPFWKEAMEMVLDVEPDEDAAKIPDVSIVEASAELLYGLVHQRFILTRAGLQAMVDKYEAGVFGSCPRVYCSGCNVVPCGRSDLPGLDTVKLFCPNCSDIYTPPSSRFQGVDGAFFGTTFAHLFFQSYRELAPAPFWKPPTSSGSSTSPRSSGDSSNATQFVNPNTHGGQKRAAGKVYIPKIYGFRVSERAKNGPRMQWLRLRPRSPEELDMVDWRGRWIDEDDEYDEDEEEIDEDRPMEDFDPDAGEGEDDDEEEEEEEESHSPVKGKTAMHAADPSVRPPTPVRPPPSSASSATLRTPQDNQGSISISGVPVTRPGAGNASKVRVVRQWTTRGTTAQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCA5</accession>
    <name>A0A401GCA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0209880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610700.1">
        <property type="nucleotide sequence ID" value="XM_027754899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCA5"/>
    <dbReference type="GeneID" id="38776704"/>
    <dbReference type="InParanoid" id="A0A401GCA5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9581" checksum="DE0654CAAC621552" modified="2019-05-08" version="1">MLRSVVCVPYFAPRVYSREASGIALVSVEKRCNVSAVIEPHSSSSPVENLIMLTKCSLRLRITNEGVSATLLEALFLSKQLEDFPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCJ0</accession>
    <name>A0A401GCJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative urease accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0210910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610802.1">
        <property type="nucleotide sequence ID" value="XM_027755001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCJ0"/>
    <dbReference type="FunCoup" id="A0A401GCJ0">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="GeneID" id="38776806"/>
    <dbReference type="InParanoid" id="A0A401GCJ0"/>
    <dbReference type="OrthoDB" id="2550922at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01385">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="299" mass="32896" checksum="CD6919DAE35567AF" modified="2019-05-08" version="1">MNDDEAYILLLLSDSNLPTGSFVASAGLESYVAHGLFVSVSRSGDALDITTNFVRDSLATYARSALPFVSDAHRLMEELMHSTWDDVEKGKERLSSALDSVKALDNLYEAMTLNHVARRASKSQGVALLTLYSKGFSKPSMSLSHSREYAGQVDIGATREARPGKFIDALKFKIRREDNHGHLPVCWGVLTAALGLSLERSQFLHLFLHARSLLSASVRLNTLGPYAAQQLLLHVVKPLVEVETSRCKHLRTGYDKPPSVSADSDNLLQEVSLGPAMTWPLGEILAARHDLQHSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCW5</accession>
    <name>A0A401GCW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610894.1">
        <property type="nucleotide sequence ID" value="XM_027755093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCW5"/>
    <dbReference type="GeneID" id="38776898"/>
    <dbReference type="InParanoid" id="A0A401GCW5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="907" mass="100053" checksum="6FF31605A4263B44" modified="2019-05-08" version="1">MADAKGCKTLVQSLHQKLKTQFVDASNYDDIIVETKIREWLNNHARHAQEKVTKKHMHVSGKPNAFKVWDALERDKVTEATRALAADKGCNVSKVWRVARSAEWAKLSEEEQKVYEEKAESWRNGTLNDKTKMKLREQRMMQYLKKFAKTMWDTMGIRMAFMLAYPKEAGSLKVEMVEVNHAITNGTPFGAYPGWLRAYQPLAKVFSEWAKGEYGVTETTVTVKKTPADCMRAMDKIRLTANGFPLLPSVPEGMAEAPLKVMKVQVRDFMNHHYALAKGVRNCKSPWTKLNSIDDINEVIPAEMLPENFQWIDPSKMTSVPYFDKDGEAAPAKYDPLPPLDGSAQALEEGSEHEVQEALTPKKAGKAKKKGKPVRKVMGKAASKATKGKAAPGRAKGGGRKRKTKDAYDSEDDARSSQDSDRSSPDIPSMASEEDMASDEDSGDGESVIANKAKGKAVATTSGCKANNGGAPQASSSGAKVKEKRDRQDLPLGALHRFDTEETDEASSELEPSTKELRLELQGRAPHLTGGSTVGSTVPHLVKRRDVFLATLSIKLQYQDMLKQVKIATVPQVYHFTRYDPIPWSEWSYGQRYLPLSFHAVDNFDIVENWLGDKPWLTKYRFLHPQGVQQSALVIGMALRDLTRSQFIEEGEPTNLPDYVVNSAISFDAVEQLLRCCEIITLDMVEGNVTHAMVKPEEQEGDASARTHDGAATAAKVHKAHQPALMADKPIIPSGGDEGPSQETSGGASDDGEEDDAHLSVPSSGAERPPPPPFIPKTRKAAATEDRLSGQAKALQGRSITDALQSNIPGRITRSQRQAMDESPAKNTRSQHPLGAVKDLKKLPDPKRKRQPARPEPDGEDSSGEDNPPPRKRGHGTRDELVVASPRKKNARAEDSDDGDKPPAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD01</accession>
    <name>A0A401GD01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0212270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610938.1">
        <property type="nucleotide sequence ID" value="XM_027755137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD01"/>
    <dbReference type="FunCoup" id="A0A401GD01">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GD01"/>
    <dbReference type="GeneID" id="38776942"/>
    <dbReference type="InParanoid" id="A0A401GD01"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039772">
        <property type="entry name" value="Bin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF0">
        <property type="entry name" value="7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51515">
        <property type="entry name" value="BIN3_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="8">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="283" mass="31854" checksum="CE9C0EC07105A73E" modified="2019-05-08" version="1">MSNSQPVHGNYHGYYTKRLFVRDPRLAVLPPSTFAGARVLDVGCNEGFVTCEIAQSWGAKKVIGVDIDDTLIRAAWKRRRTVWSSQEPSRDNQTLNANMTQTNGRKRRRESVASDDESTSTGRAQADYFPLSCEHMFGPLPILSTCKSGDSTNFPHNVAFRAADWVNSEIPEDKEGYDVILAFSVSKWIHLNGGDEGLKKFFRRIYSVLRPGGTFVFEPQDWDTYAKAKRMDAKLRENAKGLKLRPEDFERILTEIGFGPAQHLGMVGQSGFRRPIDVYIKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD75</accession>
    <name>A0A401GD75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0213420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611052.1">
        <property type="nucleotide sequence ID" value="XM_027755251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD75"/>
    <dbReference type="GeneID" id="38777056"/>
    <dbReference type="InParanoid" id="A0A401GD75"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="11310" checksum="E05697E8B7EED703" modified="2019-05-08" version="1">MAAHPAKDDFAMGYERLADGKRIKDFITRTVRDAGAIHGDEELTTDQTVEGVGPDVMHDASDAPLPNILFNGQLLEGSSDSADEDGILSVLDDSDVSTSDSESEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDG1</accession>
    <name>A0A401GDG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0213710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611078.1">
        <property type="nucleotide sequence ID" value="XM_027755277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDG1"/>
    <dbReference type="FunCoup" id="A0A401GDG1">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDG1"/>
    <dbReference type="GeneID" id="38777082"/>
    <dbReference type="InParanoid" id="A0A401GDG1"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="4">
        <location>
            <begin position="198"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36488" checksum="6877F75264F9B54A" modified="2019-05-08" version="1">MAQAVLPFSVAGFTPIPVSYSDSSTHVLYARAHTGPKKPKTDSKGKAVVLPEDRTLFLVNVPPDATERELTLFFKSSGTVEKVLFVGDAEETDEPSDGESDSDEEQEAAESDAGSDEDANERPRKKRKKGRAVAPQVVPLPSRPLRTFRRTGGRAHVVFLDASSLARALTPPTKPKPWPTDTSVPLGLAHYTALYASLRPPLDTVKAHADTWMAHFDFEEAKKKQESKYKKGEAIVDEDGFTLVARGGAYGKTLGGDVGVASKKFQNQQQNGGGKRNRKKNDKKEKEGFYSFQIHEKRRKELMDLKKKWEEDKANVEKLKQSRKFKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDH6</accession>
    <name>A0A401GDH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0214480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611151.1">
        <property type="nucleotide sequence ID" value="XM_027755350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDH6"/>
    <dbReference type="STRING" id="139825.A0A401GDH6"/>
    <dbReference type="GeneID" id="38777155"/>
    <dbReference type="InParanoid" id="A0A401GDH6"/>
    <dbReference type="OrthoDB" id="3344688at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="136"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="483" mass="54937" checksum="AF80432808DE309A" modified="2019-05-08" version="1">MMILINARKAGWTHQASPDEGTSAPQSPAKNPQKRRQDDDPDQREESGTDTPSQPRQTRRKTVRHDYRLMHDPEADEDLDNDPDKSNAELVYIAMSAHGNADADEPKTLSDAKRSLEWPKWEQAVQTELNQLQGMETWELVEPPEDRKPVGNKWVLVKKTNKEGEIIKYKARLVAKGYSQIPGMDYTETFTPVVRLETIRAILGLAAILDWEIGQMDVKGAYLNGTLKEEVYMRQPEGYSDGTYCICKLKKTLYRLKQSGREWNIVLNRKLLDVGFKRLFSDPCAYIQIKGDKIEIVTIWVDDLLIFTNDCALMDQLKRELQNMFEVTDLGEPQKIVGIEIERDHSKRTIKISQTKYIESILHKNGLTNANTVGMPLDPNTVLEKEEPETDDECDRDNGYASLIGSLMYTAIVTRPDIAHPVQWLSSFTANPGMAHWTAAKRILRYLSGMRELGIIYGPIADVKPEDQSIFVGYSDADYANDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE58</accession>
    <name>A0A401GE58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0301830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611381.1">
        <property type="nucleotide sequence ID" value="XM_027755580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE58"/>
    <dbReference type="STRING" id="139825.A0A401GE58"/>
    <dbReference type="GeneID" id="38777385"/>
    <dbReference type="InParanoid" id="A0A401GE58"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF4">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="114"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="409" mass="46414" checksum="2EDEB5DDD3032C32" modified="2019-05-08" version="1">MAIQGVLHSNYEHLVKLYADHLDTALYLQKRVVEDILPGLVDEFQLDSGTEERVRQWLEDIPSIFRVLKRNKFIASFAMESLRTTIAWRIRELPHPIPGPPTSLLRCFPSAACDPFGRPIVLLKLATMTEALGDVRQSIINSMEILRLHLMKVNVKVSTEDPVPRPVLQCVMLLDVDGVSLHNLQRLDLATWYIYELMPRFPGMLAAVFILNYTWSYSGMWGIAKRALPASALSRVFFPSPAELIEYFSPSSLPHEFGGCLPPLSKLEDPLRIHTYPLAAEFVEHSRPRGQPSPPHPPSIASSSVGASLSPTSSSNPFFGYPVSYHTSTPTLRHGRRRKRDLLRTLARLFWARWHFHISASLCLLLVFVAATLVRRFRKQERRGLFEYLTMPPRLVRSATAFARSQIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE73</accession>
    <name>A0A401GE73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611392.1">
        <property type="nucleotide sequence ID" value="XM_027755591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE73"/>
    <dbReference type="GeneID" id="38777396"/>
    <dbReference type="InParanoid" id="A0A401GE73"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35955" checksum="07F40CB44BB2EF39" modified="2019-05-08" version="1">MFRLRQHRVSASGVFTIRLYNLDRLHVSSSNTPHLAVAMQQPTCSGLRVESLADSHVIFHAVMLGILPMVVRRLDPDERQLIHPGCVFVWEERCPLAQATGTGMERWTDGRRWGPSRVRDEFLLYQEVLPELDADEEVSHRQLRNRLVKKSYSVLVDLERGRRKWHLVAYYTQDSLERLHTIADIPTLAALRGYVPEGKYMTARSSKVRTRAEKGGASQVANQVSVFSEPPGPYEPAPGAPPSPDSYSAAFPESKPSPTPTALSTSVRLPDIHQAQSPVQRRRSASQDLAPLVYLKTLPYMPRHPIDAVALRSFDRAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEW7</accession>
    <name>A0A401GEW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kti12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0304290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the KTI12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611623.1">
        <property type="nucleotide sequence ID" value="XM_027755822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEW7"/>
    <dbReference type="FunCoup" id="A0A401GEW7">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEW7"/>
    <dbReference type="GeneID" id="38777627"/>
    <dbReference type="InParanoid" id="A0A401GEW7"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12435">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="226" mass="24996" checksum="95FCAEA99EBD3267" modified="2019-05-08" version="1">MQRQMGQDTILIVDSLNYIKGFRYQMYCAAREQKVRVCTMYVVAPPELCTKWNAARPEGEQYAPETLENLLKRYEEPSSMVRWDSPLFTVLWTDADVPADNIWKAVMEGAVKPPNAGTQAVPKAPTDALRALESTTTSVVAAIMAEQSSGSTGGTIVLSLSTSLKPRVTLPPRSVTLSELQRLKRQFVTVHKKAITLGTTEKGAVDWSEESVAENFAAYIEANLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF66</accession>
    <name>A0A401GF66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS glucose transporter mfs1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0304840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611678.1">
        <property type="nucleotide sequence ID" value="XM_027755877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF66"/>
    <dbReference type="STRING" id="139825.A0A401GF66"/>
    <dbReference type="GeneID" id="38777682"/>
    <dbReference type="InParanoid" id="A0A401GF66"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="71"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="569" mass="61391" checksum="C08992EACBCE2176" modified="2019-05-08" version="1">MLQDVDRRSITPDPEDTDNPEGTSCSHPLLPAGTTLRGGTLILDPDGHSYTYAYGPKGIPGLFHNYYALGCAVFASMGGLLFGYDQGVIANVLVMKEFTARWPVGAWEKGVMTAVLELGSLVGALISGVFADRYSRRQSVLVACVVFCIGSAFQFGAQTLNHLILGRAIGGLGVGALSMISPLYMAEISPPELRGSLMAIEQFAIVLGAVLGFWVGFFARNIPSAMSWRTPLGIQLIPGVLLAFGCLFLPPSPRLLVSQGRIEEALRSLAKMRLRSSAESDTDILLQIELLEMQAEATLIEQTIGSAPKSGAIRTEANAWARLFSHKYINRTSIGVLMMFFQQWSGINALLYYGPTLVRSLGLQGDEVTLIVSGGIGIVQFLAVLPAIVLLDKTGRKPLLRGGSTVMAVSHFFIAILVWLHEGDWASHAVAAWISVGCVYVFTAAYGISYGPIGWVLPSEVFPLSIRSKGVSLSTASNWFNNFLVGLLTPSLMDASASGTFMIFATACFLGYLWSTYMVPETANVSLEDMDAVFGSSVGQEDVELRQQIERDLGLHDLVHRWATGDNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFK5</accession>
    <name>A0A401GFK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0306730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611863.1">
        <property type="nucleotide sequence ID" value="XM_027756062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFK5"/>
    <dbReference type="STRING" id="139825.A0A401GFK5"/>
    <dbReference type="GeneID" id="38777867"/>
    <dbReference type="InParanoid" id="A0A401GFK5"/>
    <dbReference type="OrthoDB" id="2663544at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="204"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="311" mass="34076" checksum="D88FE35C43A9B74F" modified="2019-05-08" version="1">MPDMCNMPRTASDRCSLAILPPMLPPPVAPSPPLPQTLLQAPSSLSPMTPAIRTVEQQAHLTTPGPSSPSISTSLSVITINIMASPSAAPGVASSLHDPPMGSSSSSHHEFRISSGACAPAPVMAAAMHQPVGLPTPHFAVAAHGSTVPMTLTPSSSLVPQNSSLAPQALKWAVLTRKHGDEQLQRYAQWDFHGEWLPYYEYQSVHQITDIWTEWAEGIGNYLPVRLLCEEWGAKWCQNVPKLKTEANRRMKVIQLVEALQKKRNWHLDITLRFLREKYEPQYTPRQFCDFLKCDRGAGADSVLAAAASYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFP8</accession>
    <name>A0A401GFP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1168-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0307150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611905.1">
        <property type="nucleotide sequence ID" value="XM_027756104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFP8"/>
    <dbReference type="STRING" id="139825.A0A401GFP8"/>
    <dbReference type="GeneID" id="38777909"/>
    <dbReference type="InParanoid" id="A0A401GFP8"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18284" checksum="9CD91A46391D7111" modified="2019-05-08" version="1">MMKNVQGSSAGAGSGEFHVYKASRRREYERLKLMDEKAQKEAETQAFESKKQEWELQAEAKTAKNRAKRQKKKERAKVKGPEKESAAGSETNAGQVDAPLKKRRLVSGKELIFKRPGADSDEDDDDDIGPAPPEQSLEGVDTGTLRQRPVPIVDAPRIIIHEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG15</accession>
    <name>A0A401GG15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0307890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611978.1">
        <property type="nucleotide sequence ID" value="XM_027756177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG15"/>
    <dbReference type="FunCoup" id="A0A401GG15">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GG15"/>
    <dbReference type="GeneID" id="38777982"/>
    <dbReference type="InParanoid" id="A0A401GG15"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="379" mass="42233" checksum="C4D9F7015168BF7B" modified="2019-05-08" version="1">MNHVHMHVFLRPSICRRTCGRLLALNFTRRTVHPLTRTFAAFAFDIDGVLLRGSQTIDAAKRALSILEGNNPTGMKIPYILVTNGGGASEEARCQKLSKQLGYQILPSQFVQSHTVLKSVVDLYADHPVLVLGGKDDDIRRVAEGYGFKEVYTTLDVHAWNPAIWPYHELTQSERKSVKDVDFTQTPISAIFVFHDPRNWALDIQIICDIILSGGIPGGPPKVTLDLEHPPVKLVFCNPDLLWKAGYSQPRLGEGAFRVAFQAVFKALTGSEYPYVQYGKPTKATYEYATRLLQRHYKALHGRHIDPQHVYMVGDNPDSDIAGANAAGWSSILVHTGVYDPHRGPPSHPPTHEVDDVEEAVKWAIERELHRGTCSGTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG39</accession>
    <name>A0A401GG39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0308160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612004.1">
        <property type="nucleotide sequence ID" value="XM_027756203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG39"/>
    <dbReference type="STRING" id="139825.A0A401GG39"/>
    <dbReference type="GeneID" id="38778008"/>
    <dbReference type="InParanoid" id="A0A401GG39"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000084">
        <property type="entry name" value="GTP-binding elongation factor Tu family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="198"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="629" mass="68934" checksum="BDEE3D7E0AE0510B" modified="2019-05-08" version="1">MTSLRTFQDEIEDIRLREAAKHRVQNIESHKDKDHKNRVQNIESHKDKDQKKRAAAKPEVHEAREHGSVGDGGKHTDSEDLSELDKRLQTLLLSGVSSDLDRARDIIASLLTRNRGEYIFRIGAQSPHIALFAGQPLEGTDGWRGTPRASEEIDILRARVSRLVDEVGGQSSVLFDTRTTHPRAALLLRLPAPDVSLTPEVRCAVVGNVDSGKSTTLGVLTRGTLDDGRGRARVSLFRHKHEIESGRTSSVGMEILGFGPTGAPILPITALSNDPDVIRREKMGWEEISVQAAKIVSFSDLAGHERYLKTTLYGLTSGAPSCVILIVGGNAGLIGMSKEHLAIALALNVPVVVCITKIDMTPPNVLEKTIQQVSKIMKSPGCRKTPVFVKSFETAVEVSQVFAKERICPTFQVSNVTGEGLDYLRMFLNLLPSSEGDSERFQADQPLEYSITEVWSVPYVGTVVDGILNSGKIKAGDAVLFGPDSNGNFESTTVKSIQRKRAPVVSAEAGQCVSLALKRVRKAAVRKGMVLVHKSDAPPRAVRKFEGQVLILYHNTTLQNNYQAMLHCGAVRQTVRIVGMDHPQGVLRTGDRATVTFEFISQPEFIKEGMKLLFREGKTKGLGVITRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG61</accession>
    <name>A0A401GG61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutaminase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0308960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612083.1">
        <property type="nucleotide sequence ID" value="XM_027756282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG61"/>
    <dbReference type="STRING" id="139825.A0A401GG61"/>
    <dbReference type="GeneID" id="38778087"/>
    <dbReference type="InParanoid" id="A0A401GG61"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF14">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019063730" evidence="3">
        <location>
            <begin position="18"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="721"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="5">
        <location>
            <begin position="106"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="4">
        <location>
            <begin position="344"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="814"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="885" mass="94946" checksum="659FD0A903B98A07" modified="2019-05-08" version="1">MFQCLLLLLSALSLVHAQNTGSSQTFYPAAVPLAVRSPYFSAWLPTLNTSLPVSNTWPSFWALNNPSPVLGWAGHIRIDSQTYKWLGNANEPFNVSNLTSTQVTPTRTVFSLQAGPMDLTVTFLSPIEPSDLVRQSMPFSYVALDATSNDGKPHNVQVYSDISGEWLSANRTQVMTWNTTHGANAIYHTLSLQSPSPMTEDSGQAEDGTAVYAMSTSLNPTFQVNEDTTCRGQFAQSGSLTNEGEGSNVHDISTPWFPVFALSADLGTINSTSSPVVWAIGFVRDPSIEYTNSTGETELRSPYYRTQYDGIDEVIEAFLSDFSNAQTRSVTLDEKILQDASAISADYGDLVSLAARQTFGGIDITVSNGTDGQWNTTDVKIFMKDIGTSGRISPVEVLYAAFPTFLYLNASYGKPLLSPLLEFQDSPRYTLSYAAQDLGTSYPVAQGDTSPNQQGVEQSGNMLIMALAHARATGDGSLLGEHYGLFKQWGNYLVNNSKTPINQISADDQEAANMTNLAIKGIIAIQAMSEISRAVGENADAQNFANNAAAYAATWQSLAESASQNHLLFSYGEANSWALMYNLYADLLLGTRLVSETVYDQQAAYYEALSQSNPYTFGLPIDSDAATKGNSAWLLFTAATCQNTSVRDSLVAMAWKHAAFNQTAAVFPTTYLVDTGAGTRGMASPGQGAVFAPLALNIANVTIVVPQATGSSSTTKHTINVGAIVGGGVVGGICGLALVALVAFLYRRRAQRLKLGGFEGENVVIYDPTQEPLVHQVTPFAPASRPLPSLPVDSPTVYSSKAREHLEAGLMAGPSPASSYTSTSQAPSSREPPTTFGSDTQPATVSSPIVSPSDVRDLRAEVEILRRVMQDIHAERLEPPPGYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGF6</accession>
    <name>A0A401GGF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0309870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612173.1">
        <property type="nucleotide sequence ID" value="XM_027756372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGF6"/>
    <dbReference type="GeneID" id="38778177"/>
    <dbReference type="InParanoid" id="A0A401GGF6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="381" mass="42439" checksum="ECAEEBF81D922BA3" modified="2019-05-08" version="1">MRVIFRVDFPKFKPSGERRPLLNRVNRPPRRRLYDNETAAVRGAARSAASPSSLAWNTGESTSQSVFDVIRQRYRFKPSGERHPLFKRKCHSPRGPLYDKETAAVRGAARSAASPPLTRRRERVRQDVERGHAAGDLERRILEAQAQRRASRGAEDIAPTSPPFDAFERSGCVARAAARSAASPDRALLPLHHLPASVSVPYETERVHAAHRVFPTLRSREEGRAAPRGFPSESPAALRTTFFSCWRAPTRWWNVRGARRAVVARIDRLDLPRLRRGLGRRACAFVSRVRRLSMHRACMISTLEYPCVRCWAGVLRGSSLRTPEGLRSTLEPSAAGRLRPPSAVQACTRFVVLLSVAGCAIPASIVAEIHAVKAYNAAERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGS0</accession>
    <name>A0A401GGS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0311080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612293.1">
        <property type="nucleotide sequence ID" value="XM_027756492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGS0"/>
    <dbReference type="STRING" id="139825.A0A401GGS0"/>
    <dbReference type="GeneID" id="38778297"/>
    <dbReference type="InParanoid" id="A0A401GGS0"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="224"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="414" mass="46403" checksum="80D23D7B86B7A451" modified="2019-05-08" version="1">MLSSLGRNGFVESLSAARQHRNVVLFNRRLRAGSYPLVSGSDIAHWQPSSRVDVFAGRLYTTATPPQATKSAQNDSKQHIPPVISPSRKPKIELRPGPVKVSKATHTPTEPAAASPKPASTKANPEPLSPSASPDSTSKFAKATEHDFEEASKHGILAPPPEGAGMIRRLIHQGKEFFKFYWRGLKLIESNRRRAKAIRERVKTGGRPLTRWETRFIRTNKEDLLKLIPFALIILIIEEIIPLVVLYAPFILPSTCILPSQKDRIDAKRRLKQKEYTVKDRRTFELVRQRIEADSSVPVENLLDSSALAAFNGSLALPTWGPAPLLLRRLKRHLAAIAEDDALLTREDSGRWLTEAQLRDALEERGIVTEGVPQKLWQTRLEWWLSHADTAQAAEPDAWRRRVPLVAKIGTGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHJ9</accession>
    <name>A0A401GHJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0400380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612580.1">
        <property type="nucleotide sequence ID" value="XM_027756779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHJ9"/>
    <dbReference type="STRING" id="139825.A0A401GHJ9"/>
    <dbReference type="GeneID" id="38778584"/>
    <dbReference type="InParanoid" id="A0A401GHJ9"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="699"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="948" mass="103315" checksum="E05D93C621914FD4" modified="2019-05-08" version="1">MRRVHGHQSLAIFPGGVVAGAVARSTALSPYTVFRATYLVRASPGARPSRAYHQDPVLLVLVSVVLRLSIFQDRGPAVSVTRSPGRMRRVQGYLSCTIIPGGVAGAAVRSTAPSPYAVFCATYLVLARSSARLSCVYHHKTALLVMASVGLRLPNFQARGPAASVTQPPERMRLEHGQPSCMVIPGGFVSGAAARSAALSPSTIFRATYLVRASPGARPSCAYHHDPVLLILVSVVLRLPNFHDRGPAASVTRPRGRMRRVHGHLSCTIVPGGFVAAAAARSAAPSRARLFRVYHHKTMLLLMTSMVVRLPIFQDRGPAASVTRSPGRMRRVRGHMSCTIFSGGVVGDAAARSVALSPYTVFRATYLVRASPGARPSRAYHHDPVLVVLVNVVLWLPIFQDRGPAASVTTPRWRREAPSRVQPSLFHTAPHLAKLVLKPPNLRDRGPAASVTALEEGTHRFHPRLLVDCVRGVVILAAARFVQRVARRGTSFGRAPPPSWIVVCRGSMHGDVSREYATCSARPSMLNAFAEVARARGRPCRERRMPAVHTASCGWGCRKTAGKGLKLCILPPLVHPRLVSMARTSWPAPLVHSSGVLHHALQGAPTRVFRRASSKRVLRRRRGLEFALRARSGACPARERPWTQHTASQPARDRRSIGARLFTTPSTAQHAPVETVDYALGRASSSRGRSLSRHTEHTKFTRFVTDVIAKAEVPVPVLLTTLVYVHRAKPHIQIALEQWACERVFLGALIVANKYLNDSTLKNVHWALCTGVFGKRDIGRIEREFLDVLDFELGVSEADLLAHHSALVGAHPHHHHHHHHIRVREPSRSRWSDNSSETDVDMDSESSFETSSGPRTPAHAHVAVYPVKASLSHSPSPSHPQRDAVQIHPQVSTALSLFHGLPLPSFSLPRAKSMFSHSTAVSRPGPAATGCRPHQSFGTRPITTQVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHL0</accession>
    <name>A0A401GHL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-alpha-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0313340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612518.1">
        <property type="nucleotide sequence ID" value="XM_027756717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHL0"/>
    <dbReference type="STRING" id="139825.A0A401GHL0"/>
    <dbReference type="GeneID" id="38778522"/>
    <dbReference type="InParanoid" id="A0A401GHL0"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="8">
        <location>
            <begin position="9"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="9">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="677"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="693"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="777"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="870"/>
            <end position="873"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="102835" checksum="C62889EE30BF1697" modified="2019-05-08" version="1">MSLATPPTLAIVSIGAMGSGVAARLAAHGCTLLTTLAGRSPATRARAARLGIRDARIEDIAQHAELVLSILPPSAAEAFAEGYRAARARVISAEPQLPTATFADCNAVSPDTATSIGALFAGPTLRVRFVDAGIIGGPPRAGYDPVFYASADAPEALAHFASLRTWGLNVSAMEGAGAGGASALKMSYAGISKGITGLCTAMVLAAHANSPRTAQALLHELAASQPAVLQRMARGIPDMLPKAYRWVGEMEEISAFVAEGAAASSGERPGAGLGVDKGGEELIHLGLARLYERVERSLRAGEGGADVQVLKGFVEDAKRVLEAKEEGEHFLASPPSNPFSPQSQLLPPASATMPARTRASDADPLALILAPPKDESPADRWAREQREAHARAISDRIDAEIKAEKLDRKKRPEPIKVLLLGQSESGKSTTVKNFQLAYAYSSFLEERTAWRAVIHLNLVRSVNTILDVLAAELARPAPAPARPLSPPPSSPSHLHPFPHPMLPDALMHPPDDPTTTDAPAGPSNPTTEHDPETDPEGEADPDPDPDDADADADPAAPAPIPPALRLLHLRLAPLRQVQADLERTLGAPELPTAETAGKTAAPWVRPREFGVVSRSGWKSALRRVGGFGPGAEKAKAEKKVGVEGRASIGSRDEARDETASVRGERRGVLRLARASLSLTRPTARSPSPRSPSDDDADGEAEVEAEASPRVRSAAEVIASCAEDMAALWADAGVRALLARRKVRVEEGSGFFLDDVARVAARGYAPSDEDVVRARLRTMGVQEYRFIFEKGSEAGREWRIYDVGGARSSRHAWYPYFEDMNAIIFLAPISCFDERLAEDRRVNRLQDSLLLWKAVVGSELLKNVQMILFLNKCDLLQVKLSRGVRVVDYVPSYGDRPNESRHVARYFRQQFKDLSIRHSPEPRGFFSFLTSVVDTKATAVTVATVREGIQRSHLKGADVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHZ3</accession>
    <name>A0A401GHZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome regulatory subunit rpn-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0401970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612737.1">
        <property type="nucleotide sequence ID" value="XM_027756936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHZ3"/>
    <dbReference type="FunCoup" id="A0A401GHZ3">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHZ3"/>
    <dbReference type="GeneID" id="38778741"/>
    <dbReference type="InParanoid" id="A0A401GHZ3"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="337" mass="37665" checksum="B3A336DD1544CAA0" modified="2019-05-08" version="1">MVATTTEQLTALSGTTVVVHPLVLLSVTDHHARSISRTSNKRVIGILLGQDNGKTINVANSFGIPFEEDEKDSKTWFLDHNYIEGMWEMFKKVNARERMIGWYHTGPKLRASDQEINDLLKRYIARPVMVIVDVRPQTVGIPTDAYFAVEEIKDDGTETRKTFLHVPSAIEAEESEEIGVEHLLRDIKDSTTTTLATRVSEQLASLRGLQSRLSDIQKYLTDVVAGKMPVNHQIVYYLQDALNLLPDLNSAELTQSFATSTNDELLVVYLSSLLRAVIALHALVDNKATIGRAEMEETKGVDEKQQEKKDKKGEQKENNAKDKGKESNTNGSDEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI74</accession>
    <name>A0A401GI74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate/butyrate--CoA ligase AAE7, peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0401840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612724.1">
        <property type="nucleotide sequence ID" value="XM_027756923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI74"/>
    <dbReference type="STRING" id="139825.A0A401GI74"/>
    <dbReference type="GeneID" id="38778728"/>
    <dbReference type="InParanoid" id="A0A401GI74"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="48"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="479"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="574" mass="63160" checksum="F0F351101C5F7245" modified="2019-05-08" version="1">MSAVAQAMNAFRPTPESIPPQNVSYRVILPKDIPVHIQPLNPVSFVLRAAQIYPDKLALANPDVPHPVFYSYSVWAQRIQNLAYALIQAGIRPGDRVAVIAPNSPVIAEAHHGVLAARGVICPINTRLTHPEVAYILEHSGARLIIVDYEYTHLVADAKVPVIVTQDSGKAGDPYEDFLSAGRRFSKERGWTGLEWEGNEDAPAALCYTSGTTGRPKGVITTLRGSYLAAIANAYETGMNSKSTYLWILPMFHACGWTYPWAITFSSAAQITLRTVSMPLIWNHLLHSGVTHYCAAPTVQIGLVNDPQARKISNPVTAIIAGSAPTASLLEALEQKGIRTVHAYGLTETYGPFTRCYPQPYWDSLSADDRAKLMARQGYSFATADDVRVVNPPEEGESFDVELVDVPKDGKTVGEIVVRGNIVMKEYFNDPEATRKAFRGKHFSTGDLAVMHPDGTVSIQDRSKDIIISGGENASSLAIEQELASHPDVLEVSVVARPHPKWGERPMAFVILHPQHAQKWTGRHDEFGDHLKQHARKRLPGFACPEWVLIVEELPKTSTGKIQKVVLRKMIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIQ3</accession>
    <name>A0A401GIQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0404350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612970.1">
        <property type="nucleotide sequence ID" value="XM_027757169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIQ3"/>
    <dbReference type="GeneID" id="38778974"/>
    <dbReference type="InParanoid" id="A0A401GIQ3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11201" checksum="B735F38F71F3B568" modified="2019-05-08" version="1">MPSDARRTHLRPSSPAASPQHSSGPAGGTVKVGRRVSQCHGMLLRLPGGSSEVQAELMWYGSQGEVECARARLEGDTLAQSAKSRRHRMTSRPHTCVSYEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIW5</accession>
    <name>A0A401GIW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein MSS51, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0404230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612958.1">
        <property type="nucleotide sequence ID" value="XM_027757157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIW5"/>
    <dbReference type="STRING" id="139825.A0A401GIW5"/>
    <dbReference type="GeneID" id="38778962"/>
    <dbReference type="InParanoid" id="A0A401GIW5"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial splicing suppressor 51 zinc-finger" evidence="2">
        <location>
            <begin position="115"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="231"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial splicing suppressor 51-like C-terminal" evidence="3">
        <location>
            <begin position="420"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="578" mass="64520" checksum="6D246E9A2D356C74" modified="2019-05-08" version="1">MRNSLGTIHAPGATVCFGHKRPSTSLQMLLRPTTQRASLRLLTHSSARPCVPASLAPRHHTRTLFGWFKKPKPAGKFAKEKAPVLSQDDLFHSFSQSPFPAIRARGEAIQKLAPCPVCASEHSATHAHSKAAPRAVKFECPDCGWPTHCSEEHWREDEEHKKYCSRLREVNEDDHDLRSGRRLREFELPGEQDSEAAISFANWDVFWYTREFPSMDTERSRRHASKLLTYPLTIGSVLHQFSGLTLRNQRLTPEGSRSLAALRTTLHVPPGAPETEEASADKPQMRIFVLGARAESSLPPHVWEQLCLLFPSAHFHLYFIGPQVSLPRPAEDLKKPTQQPASDSAQSATDSKADSAQSAATDASTEPAPATPKVEEERALKASDEKPVYVPNIYEPPTPAPIARLKRTRESIQEYGIPSYTVPYTPQLTITGMQANYIDVHNHFQETFDPYTDCFFFFSPGFGFPSPNSVSEATGEPLLQIASPTEWGPVMPLLLASKCPIFVTGFSPADVERDVKSLSTAPEVAGEFDWVITPGQNAFGSEKWEVADFDPRVMVKTNWGVWGIRGKRRDVREKTSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ23</accession>
    <name>A0A401GJ23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0405380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613071.1">
        <property type="nucleotide sequence ID" value="XM_027757270.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GJ23">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ23"/>
    <dbReference type="GeneID" id="38779075"/>
    <dbReference type="InParanoid" id="A0A401GJ23"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="243"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="370"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="712"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="873"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1154"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1743"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1159"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1743"/>
            <end position="1753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE82158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2184" mass="238256" checksum="4CB83C6E4234A396" modified="2019-05-08" version="1">MSWWPSSWFPTLPSLDFVLPSSIQRRFISFALRRSLGHFLKPGQLNIQQIDSQIGSGYVQVRDLELDNDAVNHVFSGLPIQLHDGSLGKVTVRIPWPNPLTSTVGLSLESLHLTFYLNPTLSNTPLNPIDLAESVASVAETFMHEELTPREEAALRESLYPDLTASTHSLDDNLPGGLDPFITDEEMAHPESEPAGVSIFATLIERLLARFEFDASDIKITLVHPQHASFTLAVLEIHYGAEGPSVTSSVPTSSMKAERTSGEVRTITISGVNLTTRCLRPPRPQSPSSPAPSSYAPSPSHYSPSSPVPTSPSNHSPMPSSPYSDSSDLDEETQLLMSQSIIALPPRVASPASTIASSMYQSAVSTASTIASTKDCSPWPEPANRDPTSRSRDHPSKASPSKVPSDDGFQHQPQLAIRTNEIRDDTLISSRAEPITIRLTTPVLLHASNQSPALSQSPRFSQHSPPKASNPNAEQSNITNEKIRLDASVGIIACSLRARHIRSILDVVHSWNSHSPDYSAPHPSVSRQTSGSNLRPAWLDELEANLHVRGVVILLLPGLKVPPFGYDDGLTEFYARPLVPPRLCHGFVRLHLDNLSTCISMSSPLSHGLHGASAQRIPGVETFQAMTTELSFSLSEMSAFAFMAPDQPATGSQRVSTPTYAIPLMITDPHLPVQYHPQHISPDLNVADITFSLPVFEVINWTDPARRSTTAKLSLWRSKPPPHLHPHSLPRSHAQHTTGRSPTSASVHTSPQGTISPLSPSVSPSSARPFSFGSPSSPGMAGLANASGWPSRSTEIMQRSHSPAMAVKVSLPRPLSSRILSRENNRVQVEVDFAPLHVFVDLGLVLTSGDRYGISETLVFLEEIVFPEENARSFGGESKLPVNNRSDAGDELEENAEDVETPPSTPRASNIFFLREQEREQERERRRLERLVLDDLNLGFDYRNEGTGSKLGTTTSPVHSRRKRGAKGMKDNSSLITLRFPMIRVQVRVPPPPSCTPRSGVIVFDVHDLRLSLGGLSHDNRPTSTRFADGEPFTHTDDMTGKPLLAASWRRLVVGCSLVGEDKASSILSLGSISTDAIDRLGGQFGTSPVGPQTWPSISLIRSPASDRSGPAGLITTAVAVDIPSVHVELSKPNLDVIQLWADDLAQLMEAVSSGSSRWESDTERGDSRDPSLIGSRFFAMTRAGSQASGSEGGTIASANPQNARSETAIKLTVSNAVVRLLLPRDAEGTIRPFDIAASDVDILVELQPEGKDETVLTLGIMDISVKETAKSGSSTTFLSLTSPHSLAATRSALKLRLTSLTVPETTSKESRIRLTLSGLTYNFHPYFDWAADLGRFAQAPPGAFESVVPSERTSVSIKLVDTSFRLLAPTFPGTLIPYVGELNFSVLIVGSSPETSFQLHVPALSLFLVDDLAAVSHGSADGTVQVASHSPGALFWEGAGYSVLAELTDVDVRLVRRKEPPHTRVTIGHGDLHLHLCADTLTALTGFINDFTSMFSSPSEVTSTVPKKRQEPSILSKDSASRSLLASLDEHAFRQLPEVGAAPDMISDDLPSNMDYLDESFGAAAGLRELTDDDLDDFDADAHEPSAVASADEHGLITRYGGETIKMLHPEGMHIVQNYFDTMKPDGAEGTFSSEETTIAVRVHDCNATLFLYDGYDWARTRRIIEEERKEMRRKLAKIRQLVASGQTPDPSVEETNTLLFNSVYIGLEHNIDELEPGALIAAIDEELNEDFETASQSSWQSLKQQTSTSPVSIRAPQVRPRRKGMVRSRGASIELQFLGLNAEVDHYEPGAALVSRILITITHIEILDHIKTSTWSRFLTALREDSRGNVRETDSNMVKVELRSIHPIPDHPSVEARLRAKILPLRLHVDQDALDFLKKFFSFKDPDSLPAPQSEEIYFQQAEMFPIGIKLDYKPRRVDYRALRDGRTIELMNFFHFDGAEMTLRHITLTGVTGWSRLFDLLNDLWTPDVKATQLVDVISGVAPIRSVVNVGSGFADLVLLPIAQYKKDGRVVRGLQKGATAFVKSTATEAIKLGARLATGTQVILEQAENVLGGQHLDTITAEAVQTSPLPGELGEQFTEGDLISRYADQPINVKEGIHTAFRSLKRNFGSAAQTILAVPMEVYERSGNEGPVRAVVRAVPIAVLKPMIGASEAVSKTLLGLHNSLDPKVHLENEAKYKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJE0</accession>
    <name>A0A401GJE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AC9 transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0406560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613185.1">
        <property type="nucleotide sequence ID" value="XM_027757384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJE0"/>
    <dbReference type="GeneID" id="38779189"/>
    <dbReference type="InParanoid" id="A0A401GJE0"/>
    <dbReference type="OrthoDB" id="2751120at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="439"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="555" mass="62648" checksum="AF33B633F72C5FFD" modified="2019-05-08" version="1">MKSDTHLQEYDGELSFATDAWTSPNHKAIVAFMVHLQHKGVPLRMVLDVVEVADSHSGVNLAAAFAKMVDDFKIAIKMLGITTDNASPNDVMIDEPAKLIESFQGQANRARCFDHIINLVAKSLLHQFDVPQNGADAALDDAENALCELAKDLELGVREGGEEGEPPDDIEGLQDEREGMSVEDRTALDASVQPVKLVLVKLRKIASAIIHSSTKLLPAWLKVLADLELAERKMPRNVVTRWNSTFRMLEFALEYRLAVDEMTGDRAMELRRYEMDDNEWEIAKQLCDVLKVFNDATLYFSCDTPSLPMVIPAMDIIDEKLTNDSLDSDYEPCIRAALGMAKKTLNRYYNKTDPSNVYRIAMVLHPSHKLQYFRNAGWQVEWITTARALVCEEYDRAYAQCAVNVEPTQMKQSECTPSSNMFDNLLNTNVSKGEDNRDELECYLDADTERVDSDTLGWWYARCKEFPHLSRMAMSYLTIPATSVDVERIFNKGRILLPHLRNGLSAESIRALLCLAEWSRLGFVHDTDVLAVVSLPEAQEDDDGLEDGWDNILWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK34</accession>
    <name>A0A401GK34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0409150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613444.1">
        <property type="nucleotide sequence ID" value="XM_027757643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK34"/>
    <dbReference type="FunCoup" id="A0A401GK34">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK34"/>
    <dbReference type="GeneID" id="38779448"/>
    <dbReference type="InParanoid" id="A0A401GK34"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="228" mass="26252" checksum="AF3B8DF9E3550762" modified="2019-05-08" version="1">MANTTVRGAQAIHGQNPQYLVETVVRNRIYESTYWKEHCFALTAESLIDRAIGLKSVGGVYGNQKPTEYLCLLLKLLQIQPEKEILLEYLQADEFKYLRALAVMYVRMTFRAVEVYEILEPLLKDYRKLRYRNMGGYSLTHMDEFVDSLLTEERVCDIILPRLTKRDTLEDTGEIGPRKSRLLDAMEGKSERGSNKSRSRSQSRSQQSNRMGSASPVAVPCWITIRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK47</accession>
    <name>A0A401GK47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0409170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613446.1">
        <property type="nucleotide sequence ID" value="XM_027757645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK47"/>
    <dbReference type="FunCoup" id="A0A401GK47">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK47"/>
    <dbReference type="GeneID" id="38779450"/>
    <dbReference type="InParanoid" id="A0A401GK47"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000440">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="230"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="455" mass="50899" checksum="A35FA07DE8FA50C0" modified="2019-05-08" version="1">MPPKENWDKWEKKVNDKEEKEIKALDDSDIQILKTYGQGPYAARLKQIDKDIQEVRKRINEKLGVKESDTGLASPNLWDLPADRQRMGEEHPLQVARCTKIIPVDPTAAEAARAVNPQGAMQGQKGADEQDKYVINIKQIAKFVVGLGDRVAPTDIEEGMRVGVDRNKYQIQIPLPPKIDASVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLSPERFVKLGIDPPKGVLLFGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARSKKACIIFFDEVDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALLRPGRLDRRVEFSLPDNEGRTQILRIHARSMSVERDIRFDLIARLCPNTTGAELRSVATEAGMFAIRARRKVTTERDFLDAVEKVVRQGTKFSSTPLYQVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK81</accession>
    <name>A0A401GK81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative reverse transcriptase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0409380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613467.1">
        <property type="nucleotide sequence ID" value="XM_027757666.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38779471"/>
    <dbReference type="InParanoid" id="A0A401GK81"/>
    <dbReference type="OrthoDB" id="3248529at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1451" mass="161505" checksum="011D06B12A1E8291" modified="2019-05-08" version="1">MPQTRAAARQQQAPISSPAPIEGSAQERSSSAPAPSPFRIKILARRARTPPPASSPLPAVPPRPRKRVRREPVAEPPLPEALSPFAAFNSDEDIPWMTQASANASSPTRPTLSHRSRESSPIQANNALSTPSTVRSSRAAVRALLSNACSSHVLKYPRLVRLPILPTLHCPSQPLALSCRLHLYSCFYASLYLSLFSRVHISDSSPEGLVLATSRHDFPSQSVQLAGNMLPDLPAVVTCMEKGWKQYIPLSLLTNQACKTAALRASKEHLKLDNGSVSIAQAPLDARGEKHLTTTDFMEASGRFLNIISVHYPDVSGRALIHDQFEKHFHMIVRRVDFGQYPGLYVEYDIQIRRLHASGRRFRPADWQHEIFTNICDEFLLGSASGRFTSAGYPVENAPPAFLSVQPRSSVNSRPPQRTSFRADPKPNDAYNLSTLLATIRCFLCGATTHVGRNCKHNVLPFLGAPSLTVIVSTSAPCAANPVMGPMLAQKLDFCPIVTPLRWSVWRDELEAAGCLDSFLDIPSGIRDGFHIGVNSLPSSTYIPRNHSSASDHPEVILDYIATELLARRYFGPFHPSRLEQLIGPFWSSPLGTVPKANSPGVFRIIQDFSYPRHNPAMPSVNSDIDSDDFQCEWGTFAACVLLILRAPPGTQASVNDVEKAYRCVPIAPQHQPLVVIMWKGLIYMDHCAAFGTSSAPGIFGRIADAAVRIFRHHGVQDVIKWVDDFVFFRYPSGTAVDGSHLYSYDESLFFSVAERLGWPWSMSKHMPFADCFEYNGFRWSISMRTVEIPLRKKEKYLSRLQPWTAGCKVTRKDCDRLVGTLNHCCLALPAGRSRLPSLYRLSASFAHTSSEYVRRSVSSAVLDDLRWWHDQLSLSFCGSSLVIPPRDNSRTIFVDASSSWGIGLVVNGRWLAWQLVPGWKDDGREIGWAEMVAVELAVRFLIHDDVCDSRITIHSDNKGVVGALDAGRSRGVQQNRILQHIVSMFASHGIWVDMEWVPTKDNPADGPSRGQLPPDTYKLSLYPCSQLHPPLILRMHSSCTMVSTDLSASLDHFFDFIRKHPTERYPSRHLRSTPLCRFSPYPKPRSTHNAHGPTRLVLSAAQIHPGATLMSSAADAKLLHVLDASLADSTTKNYRSSLNSFFRFCDAERVPPLFRLPASEHLLCCFAASKAGLRPRNTVQNYISAVRAWHIIQGVNWNGGLRLSYVLRGVENLAPDRKPPRPPVTRVMLELLHENLDTSIPLNACIVAAANTAFWTQSRLGEILSPAMHSYDPRKIPSRQHLSSPSTEHGACTLHYPWTKTKKYAGDKSTVTRQLGSSDPIASLQHHLLVNDAPVHFPLFTYHDRSGSFVCLTRKLLLRVCNTIWKQRGIAHTTGHSFRIGGTTELLMKGVDPAVVKVMGRWSSDAFLRYWRNLEIIVPLHAQLLAPRVQPFLPSTLKSRSRKHVTFKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKM5</accession>
    <name>A0A401GKM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613615.1">
        <property type="nucleotide sequence ID" value="XM_027757814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKM5"/>
    <dbReference type="GeneID" id="38779619"/>
    <dbReference type="InParanoid" id="A0A401GKM5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14277" checksum="C5237D677D1F190C" modified="2019-05-08" version="1">MDVVSTSRPPSSDTCMSLLEEIEDLKCEQQKLMQLILILEKEVKTMELRVEQSERRAVHVREFAEATADLAALVRAERGSLSTPPPPPYGAYVDQNPIDDTCIHYSQVPELLAGGVGFAVHVMYLAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL71</accession>
    <name>A0A401GL71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Versiconal hemiacetal acetate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0413080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613834.1">
        <property type="nucleotide sequence ID" value="XM_027758033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL71"/>
    <dbReference type="FunCoup" id="A0A401GL71">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GL71"/>
    <dbReference type="GeneID" id="38779838"/>
    <dbReference type="InParanoid" id="A0A401GL71"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="348" mass="39246" checksum="346B861E1E8A54E4" modified="2019-05-08" version="1">MSTPENKKIPYVRLGNSGLKVSKIILGCMQYGSPDWQKWVLGEEEAIKHIKYAYEAGIQTFDTADMYSNGLSEIILGKAIKQLKLPRAEIVVMTKLFNPIIPGQWGANVRISGKSPEDFGLVNQHGLSRKHIFESVKGSLERLQLDYVDVYQCHRFDYNTPIEETMQALHDIVKAGYVRYIGMSSCYAYQLHAMQNYAIKNNLTPFISMQNHYSLMYREEEREMFPTLKMFGVGSIPWSPLGRGLLTRPLGEQSTRGSTDWFIPNYKGTGTPEIVKRVEEVAKQKGVSMAQIAIAWVISRPGVSAPIVGMTSLDNLKDIIGGVYVSLTPEELKYLEEPYQPQTILGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLA1</accession>
    <name>A0A401GLA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0413380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613864.1">
        <property type="nucleotide sequence ID" value="XM_027758063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLA1"/>
    <dbReference type="STRING" id="139825.A0A401GLA1"/>
    <dbReference type="GeneID" id="38779868"/>
    <dbReference type="InParanoid" id="A0A401GLA1"/>
    <dbReference type="OrthoDB" id="3269791at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="232" mass="25381" checksum="7E5811CF892CBF59" modified="2019-05-08" version="1">MWPTTCVGHQRCARRLELLPDGFPTYAALVSAWHTYLTEDRARTSGSLYSEVTERCRASEFSRAILDTASLAIQARDALIEAIDGKVIDLSSIGRNDVKVVFYFDGADDTLFKARHLNSGIHLHPFCTCLARISVSALLTVFLSTDADIAPLPPVSGPFIAGSFRQAPITETPFDCSPAFPLRAATLTLQDITSLHFLAQFGRPLFWTLLGTGILSGRIVSVLHLATPPSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLI4</accession>
    <name>A0A401GLI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0500910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613960.1">
        <property type="nucleotide sequence ID" value="XM_027758159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLI4"/>
    <dbReference type="STRING" id="139825.A0A401GLI4"/>
    <dbReference type="GeneID" id="38779964"/>
    <dbReference type="InParanoid" id="A0A401GLI4"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14014">
        <property type="entry name" value="STKc_PknB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1134" mass="127557" checksum="69276E23765B1397" modified="2019-05-08" version="1">MVAPQPPQEATDIFSISDQVLADRLRFIEEIGFGNWGSVWLCRPKPDPASPSHSPHAMRDTKIAVKLVHRSKTSTTAARVRSLWNEMKVVRTFKHEPHPSIIPFYSFIITPSYALITMAFHPRLIPVEVPESHAKDWFHSLLSGIQFIHKRGVVHNDIKPANILLSQDNVPVLIDFGFAERYDVDTSNAFHSNLSYGTPEYLSPERARGLPHDTRKSDIWSLGITFFEVLIGRTPFEYSEGEQFSTKEDLEEYWNRTLSGKWVGNWKMSKGMENLLLRMILPNADLRCTASEAMTDNYWSQSEILIPNSRKATTSHAPALSLGLEKDVSKLFDIPPWSPRAQKEKPKTEREKARKVEVKENVTRSSGTGPRAMHRKADRPASALQPLHHSRSQSQPRVQVFEARGVSQTRKNAAMPSLLATLSPVKHSPPAVRRIVSNSAAAKENAPQTSQVKTARMTRKPLGPRSPTPPSSPASQHTPSIHFKDRENLGVPALEKDKGSRRSRVFRDLTGINRNVEPNKTEKRENKSSVRDRMREWERERERLREMEMLEERLKEAEEEREREREMERERERGRALEEEKDRVRQQEDRERELKRQRELAEERELAREREDLARVLQLEKELEDPKVRLGKSRSLSPPDSALVTPPLSPVIEDPSECSWLPNEVYSRSGNESGISLLKQSLKLSFGMFDKTLKLYRSSTQALGRSTPMLMLLDETSHREPSGSLSPRAFVGDELSRSTNSSLPNDEMEASTEVDRMTLWIRSVEKVVEDARQTFSASTSSDVPPPALPLSPVSRRASLTRTNRSSRVPRKILAANHIFVDEYDSSQMDQSMTSVGGTTGYFTANASRANASSVIDHTLPTIPSEELSRVSGTPAVPQTPSRRRRATVASISPEPTSKKKISLEISVSSSPSKLKEKSRSQNDLNHIGPITPVAKLEFELGREKLVSPPLRPQRLSEVVDKNIFIASSPASPVPTDQSGNQRDKSLDELTSSPFHVDPYPPRPQAPANILDTPARKHIEGVYDRFLMSTAGVKRMGRGYQSDNVGPVLNVPPQNATAYKRNQKLFHSSRRPMPPPISSDDMQACSVDEFGVVIPPIGKRPPPHDTNKTTVTIVRKAFKAIVSGKTVSTRFSKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GME0</accession>
    <name>A0A401GME0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0503770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614242.1">
        <property type="nucleotide sequence ID" value="XM_027758441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GME0"/>
    <dbReference type="STRING" id="139825.A0A401GME0"/>
    <dbReference type="GeneID" id="38780246"/>
    <dbReference type="InParanoid" id="A0A401GME0"/>
    <dbReference type="OrthoDB" id="3351225at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE83329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="11967" checksum="44779A0FD1081282" modified="2019-05-08" version="1">MSILVGPAAGALVAGGIYYGFSSMMHSWTERHRSDLHTLSQRLLEAPSQVNAPPAASERITHHPFSSMLKGEWNAQVATLFRNVGEWNRRATEWGRRTLYGGESRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN79</accession>
    <name>A0A401GN79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0507070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614565.1">
        <property type="nucleotide sequence ID" value="XM_027758764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN79"/>
    <dbReference type="FunCoup" id="A0A401GN79">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GN79"/>
    <dbReference type="GeneID" id="38780569"/>
    <dbReference type="InParanoid" id="A0A401GN79"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000899">
        <property type="entry name" value="Chromosome 15, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="597" mass="65583" checksum="796BE314A4B6102C" modified="2019-05-08" version="1">MPDSFFVTSKPRKRKRSVTQESGPSTSKKFAKGVNGKSATKGRGRASGGTPNSRKRRDEELSDETDEGEGEGIDEMDLRAPDVLPDAYESGEEDEDETPAEKRLRLAKLYLESVKQGLATAEGEFDAAEIDRELISARLQKDALEHAGKVHLFVAESYDFTHAPKLRLRGHRLPTTAAVGSTDARWLFTGSKDGSIVKWDMYTGRKSYTFYKVRPVKEKEKGKAVAEIQGHTDEVWALAMSEDGRYLASGGKDRRVGVWDVEKNEWVKGFGGHRDSISALGFRKTSRTSASSSTQLYSGSFDRTLKMFDLSSMGYVETLFGHQAPVLSLDALRGETAVSVGGRDKTVRFWKIPEETQLVFRGGGGSKWVDDLDGMDIDEDEDGAAVVGGKKANQAHGKTQEKFVEGSIECVAMVDENTFVSGGDSGSISLWMTQKKKPVFTQGLAHGLDKSQVDTEDVDIVRKPRWVTALGSLRYSDLFASGSWDGQICLWKLDSNLRSFALVGTIAAPGVINSLQFVTPPKDTLDRMEWASRVTTLPDENTSSDTVNGNRRVKADTVLMIAGIGQEMRFGRWIQKKGEGVINGALIVALHPRTLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNB4</accession>
    <name>A0A401GNB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0507640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614621.1">
        <property type="nucleotide sequence ID" value="XM_027758820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNB4"/>
    <dbReference type="GeneID" id="38780625"/>
    <dbReference type="InParanoid" id="A0A401GNB4"/>
    <dbReference type="OrthoDB" id="2746456at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="219"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="622"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="908" mass="97482" checksum="8853C0E612BD0EFA" modified="2019-05-08" version="1">MAANTYTGTPSTSGAAVAASLTAQTRSGGTSEKRPAPATPADKSAKRPKLATPQSKPGPAVSSTATAAILPTSPKVLQKPDPVMSTSPSAVTHFKTEEKPQEAVPTASTPSLSDATCIKAEEPICPGTESTAFSSTSVPKSASNVEHTDAPPLTPASSSKPLPSVSVSDTTHRDVGHGGQNHTDVGPAASASASTSSTSALAFKHADCTRHSMFWQRDDFVVLRVQNTLFKLHRSRLEQESTFFADLFKRDTERPADRDTVDGCPVYLVDGTSAADFAVLMEAMDGGITYALNPLPFPALASLLRAAHALAFPRILNFASHVMRTTWAPDLACLTSVRTPNAAETIVLARTCNIPEVLKRAYYELLRSPGFHQSNDDIDDAIQRKAALEAAEYALLLAAREKLQEVWIQIASTPPDTSCPLISFSQPADAEPRRACEQAHAKGAELWAEMVGRAPVFKEGMLDPLGALENIIAAVAGAAKSSAMKKGAITKVPDGGAEPFPASPASRTRTGSSSASAAAGAASRTAQAQAGSAARTPEKRAALTEPDRISAKRRRLETSPSAGEQTLLDSEPLPFALSTVKVEQVSPKSGPAELTALSTASAPSSSAKFALCTRHPVFWHENPIVLLVQDTLFKLHRSRLEHESTYFADLFKRSSNPPLEGDVMDGCPVYAVNSVSAADFSVLMEAMDGGIMYALNPPPFPALASLLRAAHALGFPKILDFAKHVLRTMWPPDVAHVSSVRIPHAAETITLARTCGVPEVLKRAYYELLRSPGFKQTDDNHVDTCAKPSLGLAEYMRLVVTREKLQEMWIQIASAPEVLLCRLPFLPSPSDSDVERQRVCSQTRTKDVEVWAEMVVQVPLFKEGMLDPLDALSNLAALDWHARGFCLRCVNHWRRTWREELDGCLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNK4</accession>
    <name>A0A401GNK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0508380</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614695.1">
        <property type="nucleotide sequence ID" value="XM_027758894.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38780699"/>
    <dbReference type="InParanoid" id="A0A401GNK4"/>
    <dbReference type="OrthoDB" id="2789199at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="13">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="14">
        <location>
            <begin position="634"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="1188"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1495"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1495"/>
            <end position="1504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE83782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1516" mass="172077" checksum="8BC0352E0A0A02E4" modified="2019-05-08" version="1">MDPQAQLAVLAAGLPEDTYHALEAILRDLDHRVTHAQAPALSADDIRIALEHGFANTQFNLPPAHFTLPPAPPLPPVSVRPGQFKVDLAHFHGKDSDDLGAWLTLIEDYLRGQHIPEVDWPLQVPMLFRGEAQRWYVAQKKKIGRGFTWAELRKALTDKFDTPLRVETLRNELRSVPWKGNLTRYAAAFRDLETQIPEVDMTFGDRLSNFLSRLPVEFAKDIRRDKPKNVEEMYFSAREIECLSNLHHVPAQHQNNTNGFRKKTKGFTHRLFSSSSSSPSAASSSPSAPPTSSSPSTGPVPMDLDAMEQLPPLKTKDRVSRVRCFNCNGLGHYSRNCRLPRKRRPPQELNLFEGSEPPLFTDCCEEPLELSVLDLSDDAPEPHLLPTYAVQLAPSVNAKPLQLASAIIDTGAAYCYIKPSVVRRANLTTYPMTAHSVRGAGATTTSAWAHFAIKIGGWQKPICAFILDTDTLRFDMVIGQEWLQKYNAQPDWATRSWFLTDPRTCQVVRLHAMTVQQPLPLPRVAGAAASNRWASLVAAPLELYSLAEEPVTESPQETSGHKSPLAKIKSFGARLHARMKAKFPRLFRTKLGAPPAGRCEHVIDVTGTRPIRAHGRPLSPPEHEEVRKFVDEGLQDGIIEPSKSPWSAPLILIRKKDGKMRVCVDFRQLNNFTVRNAYPLPRIDDSYQNLRGAHFFTTLDLRSGYWQIPLSAASRPLTAFATHFGHYQFCVMPLGLCNAPATFQNFMNDLLHSRLDRCVMVYLDDIIIYSPNLPQHLADVDWVLTRLDHQGLILHEDKCQWVQTELTYLGHIVSIAGVRPNPEKVQAITEWPRPDNVTRLRGFLNLTGYYRRFMKGFAKIAGPMYDLLKGNPRKRAEIKWSAPCEQAFVALKSRLTSAPLLSYPSPWRLFVLDVDASGHAIGGILHQSQNDFPKGEGDCSRFAFMESDLRPIAFESHRMTPTEQRYSAQEREMLAIDHCLQKWRSYVEGSPVVVHSDHESLKYFLSQKHLGRCLARFADNIAHFDVLIRYRPGRNQLAADALSHRDGQADVPDYEASGPLFANPMEPAVDHDRSALFETLKKWREDLLRDASAEPSRRGFLVRDGALFHSVDLGQGEVFLPVPVNLDEALRVIREVHTDLGHLGVRAVAEALKSRVWLPIVTELVEFVIRRCDACQFTQREAPPAQPLHPLPRTDAFDHWAFDFIGPLVKSKEGNEYILTAMDHGTDFAYATAIPRRSHIAVIALLRRLITTHGKPSTVLTDNGEEFLSYPFQNYLQRLGIQHLHTSPYHPQTNGRLEKFNDMLVQTLARYTAPNRQDEWDQYLPDALLAQRAHVSRSHGASPFFLAFGRQPRLPHEMTYDLLRAPPTDAEIATLQNRRLEHVQNLERFRTEANTRALRRLQDEARRREGTYHERALGIGDYVLRRSENPTKLHPRWDGPFIVHDVTDWNVYQLRTRNGYILRTLYNAARLKRYHPSNMDPELWYSSADLQRRDARARMQRRLDTSLGRAGTSRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNP9</accession>
    <name>A0A401GNP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614770.1">
        <property type="nucleotide sequence ID" value="XM_027758969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNP9"/>
    <dbReference type="STRING" id="139825.A0A401GNP9"/>
    <dbReference type="GeneID" id="38780774"/>
    <dbReference type="InParanoid" id="A0A401GNP9"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="118"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="299" mass="34503" checksum="EEF942A43CF838AE" modified="2019-05-08" version="1">MPEIEYLLALPRSTVYHTLQHEPGSFNDTSTRSGRPRALTRDDVEFILEVCEIQPNIYLDELKEELELQNVDISLAALCRYLHRNGITHKRLARIARERDHARRALFVDTVQQYDAAQLVSVDEAAVDTRNMTRNFGWSYSGVRASERVPLERGIRYSVLPALSLDGVLHVNIVEGSFNAITFRHFIHTLLDRMNPFPAPNSVILLDNASIHHSEETLDMIVERGMRYIFLPPYSPDLQPIEELFHELKEWIRRNYIEGRAAMRCTNGPAHPWVFLMEGLDHITPDDAYGFFKDTGYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPB1</accession>
    <name>A0A401GPB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614970.1">
        <property type="nucleotide sequence ID" value="XM_027759169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPB1"/>
    <dbReference type="GeneID" id="38780974"/>
    <dbReference type="InParanoid" id="A0A401GPB1"/>
    <dbReference type="OrthoDB" id="2742220at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="342" mass="37671" checksum="229647E3E6BBB169" modified="2019-05-08" version="1">MVDWRSPDVIYVSGYVFSEVSVFTLGLYSWDFIMTLHHVEWPLVTCKLKFHWAYVRSSFHHIPSDSPRYPAPPQIPYILARHTTLAFLLSLVIITCSASADACPGGLKVLAMLGNLAVAGASTNLFIRTRTLWQHKYWVQIVLSVLSVGQWIVAFTVSMWNITNDLPTCGPANAHSTVEEIFIFYVYTAFFDMLILAMTVLRLFSVGEAHGSPLWVRLYRQGIWYFVTALLVGLIILVFAGLNLNPVMNIIFTVPGIVISVIASSRAVISLTKLKEAGCTNAGTHSQNATATISIGRVNQFTTNIELNSSLYDHPPDLEAQAVGKAVLLASPAPVTLSPPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPI7</accession>
    <name>A0A401GPI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0601290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615064.1">
        <property type="nucleotide sequence ID" value="XM_027759263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPI7"/>
    <dbReference type="GeneID" id="38781068"/>
    <dbReference type="InParanoid" id="A0A401GPI7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="152" mass="16850" checksum="33E1376F68966E1D" modified="2019-05-08" version="1">MSKFAQDEDLSARFAEAGLIEEVAKLSEVKGRVARAVADIHDGHYQQLSFRSNSALVIRTPDERTTTHNAFTSRRRRWIARAAYWNTRGTGTAVHTIPFHRPNSSTRAGAHHPPSRVLDAERARTDSAVLMGRGKQWSLQRAASFPCGASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPK6</accession>
    <name>A0A401GPK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615084.1">
        <property type="nucleotide sequence ID" value="XM_027759283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPK6"/>
    <dbReference type="GeneID" id="38781088"/>
    <dbReference type="InParanoid" id="A0A401GPK6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="150" mass="16563" checksum="D2E53899B7630138" modified="2019-05-08" version="1">MSNELACNHRSTPEEDAKQAVSGGERRLISVSLRGGPALLLDSRPSFLDDVEWAWSTVMSRACPEMARWSESELAARGLMGGRKKNELITVELRVGRKFVVERGLIVLELIAYEGLDGESELLQGGWDAKGIVVTEMTPIADRKVAIRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPQ2</accession>
    <name>A0A401GPQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615111.1">
        <property type="nucleotide sequence ID" value="XM_027759310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPQ2"/>
    <dbReference type="GeneID" id="38781115"/>
    <dbReference type="InParanoid" id="A0A401GPQ2"/>
    <dbReference type="OrthoDB" id="2684453at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="93" mass="10747" checksum="1711E7E6A803D9A9" modified="2019-05-08" version="1">MAQWAFSPAPHPPPALPPLALQQEPRPDGVSINADRLCAAFRGAPIHDCEHRHDQRDWRRGDPERELRGNSPYWKELVFLINVRKGFTKRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPX1</accession>
    <name>A0A401GPX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable urea active transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0602630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615198.1">
        <property type="nucleotide sequence ID" value="XM_027759397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPX1"/>
    <dbReference type="FunCoup" id="A0A401GPX1">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GPX1"/>
    <dbReference type="GeneID" id="38781202"/>
    <dbReference type="InParanoid" id="A0A401GPX1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="653" mass="69589" checksum="787F184121DEE8DB" modified="2019-05-08" version="1">MLGLTAIQARYTGFSPKNSEEFNSASRSVKPGLIASGIVSAWTWAATLLQSSAVAYSYGISGPWWYGSGATVQILLFAQLAAKLKMNAPYAHTWLEIVSARWGVVAHLVFMFFGLATNIIVSSMLILGGSATVNSLTGMNTIAACFLIPLGVSIYVVVGGMRATLLCDYTHTSVLFAIIFVFVFTVYSTSAKIGSFSEMHSLLATAASQAPVSGNAHGSYLTMRSKNGLIFGVINVIGNFATVFQDQAYWQRAIASRPATCVKAYLLGGLAWFAIPFMFSTTLGLAAVALRNDPSMMMLTPEDVSAGLPASAAAAAILGKSGAVALLIVLFLAVTSATSAELIAVSAVLTYDVYKRYINPKATEVQILRVSHLMVMFFAIVMGILGLIFYYIGISMGWLYDFMGVVLGSAVVPIATCVTWKKANKWGAIGGSVAGFCCGLIAWLVTTSSLNNKLINVTTSGGNLEMLAGNLASIGVGAVITVATSMIWPEDFSFDPTRAINNPTFVADEKTSESRASQDEVDDKKEATAAVVSEPVISAEEAALEEARELDPVALRKSFKLAAWSSVALTLILLIIIPLPLFFAETIYGVKGLTAWVVIGMIWTFFSAISVVVYPLIESRSGLFLIVRGIIKDIFKPGSGKFVHHEHVPSTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ35</accession>
    <name>A0A401GQ35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615172.1">
        <property type="nucleotide sequence ID" value="XM_027759371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ35"/>
    <dbReference type="GeneID" id="38781176"/>
    <dbReference type="InParanoid" id="A0A401GQ35"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="62" mass="6885" checksum="A59C0BA0FD8BAFF1" modified="2019-05-08" version="1">MSARVAETSLTELTNVILQRKLAPLTPLWADAWEELLSISGLTSHYPRLVSSIRFGFDVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQK1</accession>
    <name>A0A401GQK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SCP_0604820</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615416.1">
        <property type="nucleotide sequence ID" value="XM_027759615.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GQK1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQK1"/>
    <dbReference type="GeneID" id="38781420"/>
    <dbReference type="InParanoid" id="A0A401GQK1"/>
    <dbReference type="OrthoDB" id="669841at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0229">DNA integration</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="1895"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="20">
        <location>
            <begin position="2194"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="100"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="257"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1248"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GBE84503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2248" mass="255136" checksum="D5FA3EA8D91B0D44" modified="2019-05-08" version="1">MPDHKLLTLRPEMIDPRYDNTDIVYINEANWATDSLALSDPKAFFRFYTRGITQYAHFLLRQVPSTLKAKMDVNKFLDTFSMEVDAKTRAAFIPYLAGKKKGGAGSDSDSDEEPAATGDIEAVIVPAKPSGRPLPKKNSKKRPRTNLQPNLDASQPKKMCKDYATEVGLQDMLKTIGRTQTIDLSTKTKRRSKRLATRHESSDTDNEQEYLGLVGGGHDNGDDGMDVDLSGAQKGVRCSSRLGGKSGVSSHIEQHVSDGYEPDEDDDDEDNYDQEPRNTEQTPQTRKKKQPSHKVLASFYVSDESVEEGEQDQINSDQVTESENDSDTDDTVHAAVLSLFKKWNIKASHSEFSNILQGIQQQSHQKYVTAQQKLTCFLNKFNGQQRPNAQFAVSISQIWESMEVLSIKGKAISLENILAQKQIMLSNGVAWNWLNIICLRRCQKLFEPLHARKLVTSSDWFTSLTIKIYQHFEISRRSSDTLNPSTYLPGLSKSIQPWKLPVNALNGDELETRVLSTLRSVLCSWLGYPNDTSMMRGVFVTQIIQTFHSENVLLLQGVWCIYSEIKAKVLGPSFKGLRPHSLCPNMLDTIFDKLSSLPLASLESKEHSLLEDIGDLVKKALELISYPGGKPTAPTPVATSIPSGTASTSQIPTHQGLQSLLDFVLELIPLVDSTTAFPSTRIQSLVLQQLDKRLPFCKCAPSKSRVSGLDGPLHPDNIDKPGAFATQKNLSTLDFNYINPTALPEQYREHLPSQAEWSTERNAHFIGGRPVFIRPDNHNFDYSPEEFERTLPHNLGGIVLQHIADSGITTSYPGERPDAPWNPPAQNPVPQPTLAPIVPDYIPPMATVTMDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLDGTPNQMGTITHCTWKMMKIGGRKTLTCFLLTGIGKENILLGMPWLKRLNPMINWETSDFWFGKDAKWPPKPTVEDAPDEEVSIFKKDGLPELITTETSPTSFGHSESIREIMADNTERGELPTVRNDTEPDDPLSEPPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFYNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETWPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKDASIFTKMDLRSGYNNVRIKDGDQWKGMIVRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLMNLTCTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGDLHPCAYISQMLNPAEWNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSHRNGLDDSESDNEDRILLPNALFVRSISPTLFDEIRNHAAKDLIVHEALEVIAHKGPFPMKSSLSDWEVRDGVILYKGKIYVPPSETLRHDLVRLHHDSPAMGHPGKFNTLELLRREFWWHGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPNRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLRLYCGNNPGTWADRLPDLEFCHNTREHSAWKMSPFRIMMGYESRGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYVNPPPDVVDNEEEYEVEAILNHKMYRGHLRYLVKWKGYSSAENSWEPAHNLQNAKRILDAYKKTRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQZ2</accession>
    <name>A0A401GQZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aspyridones efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0605680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615502.1">
        <property type="nucleotide sequence ID" value="XM_027759701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQZ2"/>
    <dbReference type="GeneID" id="38781506"/>
    <dbReference type="InParanoid" id="A0A401GQZ2"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="355" mass="39336" checksum="0BCFB004584E77A3" modified="2019-05-08" version="1">MARRQGPSWPGGAHRALSLCFSPPGASWHDDPQPRGCVRHLSGLISPSAHCRHSRRHGFRNPRVQTLPANCSVYRPSTPQHGFISISDGGFRAWLSVLGGRVLYMAYYAVRFYFTFAGAPTSSNLFLLFSVGLPAGKLFDSGYFHATTVFGTVFYVFSIFMLSLADFLKCYSSSLRVSAWASAVGYSSAFSIQAHRWKRRHSLAMGIVATGSGFGGIIYPIMLNQLFHIAVGFAWGVRAAAFPTPGLLIIANCVMTTCLPTAKASGLSPKPEFLMIFTDVAHVLPHRNFLVLWGVFFPYLYIQLWINEQGLSSTLGFYSISILNGSIFGRIIPNVAADYVGQFNRDVRRYRHRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR19</accession>
    <name>A0A401GR19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615614.1">
        <property type="nucleotide sequence ID" value="XM_027759813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR19"/>
    <dbReference type="STRING" id="139825.A0A401GR19"/>
    <dbReference type="GeneID" id="38781618"/>
    <dbReference type="InParanoid" id="A0A401GR19"/>
    <dbReference type="OrthoDB" id="2801423at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="144"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="29678" checksum="A5CC98D55250DE8F" modified="2019-05-08" version="1">MDNVQKYVRRRDARIGHGNYMKIGLTATVAEAVDFDPAVGDIDDKRARIAQNLRAELTVEKLLGMIDIAHFRKVGTLQWLHTLVTYIPQLAKYQSAVAKLYKTDGAKLCLPSKQKTIMHPLATVAKNENIMTELRDALVDFLGDEFRSFEIIQPFLELWHTEWTHLSLTYEAHWGSLLTPDPSKLGHSASKINQKAPANLKKVNYYPAAYTSYLVLDVRMLDCWRILLETDDILEHFAALDRDGQLPLLDELQAKVEILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR44</accession>
    <name>A0A401GR44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase IS204/IS1001/IS1096/IS1165 DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0606180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615552.1">
        <property type="nucleotide sequence ID" value="XM_027759751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR44"/>
    <dbReference type="STRING" id="139825.A0A401GR44"/>
    <dbReference type="GeneID" id="38781556"/>
    <dbReference type="InParanoid" id="A0A401GR44"/>
    <dbReference type="OrthoDB" id="2638305at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12857" checksum="5B53DDEF56A67D49" modified="2019-05-08" version="1">MLNATSISLNNTFHVAGKASLVTIVENKQNHIKVLKGGILSIINEVNEIISWRFCQSQSTSEIADVLAGLRQHGELLQVPDPMLAVVDNCCHVRKSIKKALPEIDVMLDVWHFVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRA4</accession>
    <name>A0A401GRA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615658.1">
        <property type="nucleotide sequence ID" value="XM_027759857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRA4"/>
    <dbReference type="STRING" id="139825.A0A401GRA4"/>
    <dbReference type="GeneID" id="38781662"/>
    <dbReference type="InParanoid" id="A0A401GRA4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="323" mass="35276" checksum="37DF216B4CCBD203" modified="2019-05-08" version="1">MPLDIDPNYVLQAVRLTAIVAAAPRQDDPRYPDWEMRIYLEVSQLEKSFPQPLKSLRMPGIVISALLEFTRAYQQKALVRLDHISNDDERIYKRYPLAVREYGECEDLGRQWWTKDPYCKLPPVKSTPAEGWGNVPADDDTQGRGKEDLATGDLVTKGKGKERADNDVGTGMVGECIVHVEAGEDKGKGKSKEKAQGKAVHAMSEEEDGGEGEGEGEEQEGEDDDDADSDEDDDADKDDDDEMAEDVPGAGQPESIEVDAASPPPPTARPISISPAAPSLRKRKAVITESSEESENEEAAPKAKQMKPIEVAKEKGEAPTTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSB2</accession>
    <name>A0A401GSB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable inactive dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615537.1">
        <property type="nucleotide sequence ID" value="XM_027759736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSB2"/>
    <dbReference type="FunCoup" id="A0A401GSB2">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSB2"/>
    <dbReference type="GeneID" id="38781541"/>
    <dbReference type="InParanoid" id="A0A401GSB2"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="275" mass="30346" checksum="B1679BE5225193AD" modified="2019-05-08" version="1">MSSESVPKLFQPIKVGDMTLAHRVVLAPLTRYRANVAHVHGDLAVEYYSQRASVAGSLLITGATFISAKAGGYAHVPGIWSDAQIAAWKRVTDAVHAKGSYIYLQLWALGRAAKPEELEKEDPSFPYVSASDIQLTGKPKAPRPLTEDEIKEYVQLYTTAASNAVHGAGFDGVEVHGANGYLLDQFLQDVSNNRKDKYGGSIENRARFFLEILTAVTAKIGAQKTGVRFSPWGQFQDMRMQDPVPTFKYVVSQIAELFPDIAYVHCRTCFINCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSE5</accession>
    <name>A0A401GSE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0703220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616049.1">
        <property type="nucleotide sequence ID" value="XM_027760248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSE5"/>
    <dbReference type="STRING" id="139825.A0A401GSE5"/>
    <dbReference type="GeneID" id="38782053"/>
    <dbReference type="InParanoid" id="A0A401GSE5"/>
    <dbReference type="OrthoDB" id="2278929at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="466" mass="48915" checksum="C0AC5A237175452B" modified="2019-05-08" version="1">MSSSSRTLTPAWPAQTPSSSSSFPSLKRRRQLDHRSSSSTPSDRVDRHARSPHFLSRDDIADQQQVAAAKNTCEDSPNNVISCWPLENTTVPQHEWATFVWNSRLPQYAQTNLVNIYLYHGDSQELVFSEFNIANPTNQAGSYPAQVNDTWFGARGASWNGDNISFPMYWIITSNTNPSDQSPLPQSTFTAVQTTYADSVVAYMSSTSAAAASSASAASAASSASAASAASAASASEASASSAVAASRSAASASSLGASSTVSGAQSSTSVAGSGSVQSASSPNFPHWAIAVIVVLGFLALVAGGTLAFFITRRIRSRRTSMLSHRGSMGSSTPMMTNAGNAPLSPVLGATVFGGNRPPTPTETHEIHDGASTVSRASDTALFSGADAAIMADAFRKALRKPDFANQTMEEGDSPEDPNMVEQHPAVLLSQELAEEGRDIRSVGSSRDVRVETLSDDAATATDHPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU15</accession>
    <name>A0A401GU15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616593.1">
        <property type="nucleotide sequence ID" value="XM_027760792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU15"/>
    <dbReference type="GeneID" id="38782597"/>
    <dbReference type="InParanoid" id="A0A401GU15"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="477" mass="50973" checksum="0D470FA75BACDD8D" modified="2019-05-08" version="1">MPLPLNMQHSDMDMTRSMPINYNIVAHITLLEYEPNDPRLLSPIVGDSTSRVLAGVTHLIVAMPFSHLPSDPVGSDTGLENAIFRAKYWRDCVTQRFGVPRACLLTVCRMPKTPRVYEPTAKVLQVFESGEFILWFNKCRSSSDISFEMRTMSATPNTERFPPLSTAAFRRAPRNAQGGKQAQSTASSTDIRSASLKASQSNSLENGRVAYPHASFAGYPSLTPSPASAQQPMPMNHPTRHFVQPCQGGHMHRQVPSMPSQVHAASAYGSYGATNTSAGLSAPSPMGPPVAPPLPSQPTNLPRDSQQVAPLATARWLYTPSLATVPACGPSPAPVPTPTTGKRRRCAEEETDSVEVPAPAPKKPRKATKKAAGKRKGKGQGVVTADIVPFQLEELEAAWAADQVMGASSFSAGPSMLATAPPIQPPVLLSALAPLLNLAPGTRKSRKRTSTATETDDATALPPAKKPRARKAGTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUS3</accession>
    <name>A0A401GUS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0804630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616852.1">
        <property type="nucleotide sequence ID" value="XM_027761051.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38782856"/>
    <dbReference type="InParanoid" id="A0A401GUS3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="7">
        <location>
            <begin position="255"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="8">
        <location>
            <begin position="752"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="720"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE85939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1479" mass="165274" checksum="5232C99A8B2FD549" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQPPEPAIHLIKMSNLSPMPLTDQIAGVLELMFHRKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELERKWPPPFGESEIRIDQPATLVDMHGRILAWILPRVLIPDRQTKMLQATRALHPAIAASKPSSTTASWRHNPLYFLPPEECAQFSAGSLCLSPGWFQQVREHMESGRLETSASLKLEGGRSWLRDIHDSSALLGAILAVVHPTLYAAGRQCLGLIQQDPELREMALNWSSPFNALQVIANWETPFHRDSKTRYTFYDLLATLGNYTCAWLKFPAMRVAIDYSPGTVIAFCGKAIRHGVTRADGERLVYAYFMREGVQNRLGIPAPHWMQASYYASHIGMCTVHHRRDIMPKTDGDENTMQGMETVDGSFIGGIKLAEVMAKSQGVVITDGSIWLADLEVGGDGGEMCSVEKLRNKSRLVVDLDDEVEFVTKVAKQTTRGVRYVDVPLPMPTGSNVPSPSKSPSKAPALGSLFNLDDGDVLGNIGVPIQLDPAARKTKTQNDFMRDWIPHRDDYLHAIVEMEAPPEPRNCAECKVGEGRWRCLDCMGRALTCTDCCRNGHQRAPFHRIEHWQGQYFEPASLYRVGVCIHLGHGGDPCPLGAFTAHNNPAPVVAPGSDFWNASNEDLNAHDGEVSDDGEVPFNFAPLAGTLDGEARQTDDAPDPTWEEDVPPVLSRPPRCDSYGNRIIVIVDISGVHHIGVDWCQCEMAVECDMQLLQMGLYPGTVKDPHTAFTFAVLDDFLLENKECKMAALNYYSKLKRVTSNAFPGTVPDHYRELMRVSRQWRQLKYRKWHGFSHDALRPVEKGGLAIFCPACPQPGLNLPFDWQADPVQWKFKRGFVMDGNFSAEHMKMKHPEEDVALSDGQAFMVGQEDYKAHLAVAMESHQRSTCHEHRAVNQANVDRANLDATGIGATACARHGFFVPHTVVDFQKGERQMNMDYSLSNALLTLTGITLILVMYDIMCQYGVHVRKRFRHSAYLRMPFELKIDQGIGLFHVHGHQDCCFQRFSPNFIVGAGMVDGEVIETLWAPTNEVSGSTRGMTRAHRQEVLDDHMNDSNWKKTTRMVPTLMTKWKHVLLGFPRSKESFEALSASTDEEVLEAWQKEYDDAMEARQNDPKIMDTFDVQLRKAPGKDLTQLRLAGEESAKGLEKGTAGWLSTGLKIQEAQLKLANDICKAGQNPSMAEDLKTLERRQHLEVSILTFQCRSEKFMGRLEDVPAMEDRDDGALWDSLDENPFQIHPEDAEYDEDAIPPERASLNLPSQIRFVAAIANGLQTLAAQELELRKGLMNDILHELHMVLGLKSYLYRKRVRPANSVGTMTRAQAEVHAANQTVLACARLYSTNRRAIMRLGATDEDLALYRPLDKKDLHVKTAIIEASTSGLRNVNLAWFWTMDVAGDRGSSEWMDECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVI5</accession>
    <name>A0A401GVI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc-regulated transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0901140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617148.1">
        <property type="nucleotide sequence ID" value="XM_027761347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVI5"/>
    <dbReference type="FunCoup" id="A0A401GVI5">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVI5"/>
    <dbReference type="GeneID" id="38783152"/>
    <dbReference type="InParanoid" id="A0A401GVI5"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE86235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="416" mass="44477" checksum="D3CB9F5669A8CEC9" modified="2019-05-08" version="1">MPFHLRLDHRCSPSQPPLHSPFPHRTLSPTLPQPFTSEIPLNNQKRPRTNLTMSSSDSTVNGVYCGTGGGANSYFHLRVASIFIIMATSGFGALFPVLSKRTRWLDAHLPDALFQTAKYFGSGVIIATAFIHLLSPAMAELGSPCLSAAWQDYPYALGICLISIFSIFIVELVAFRWGTAKLAKIGLSHDAHGHDIGQHASHAAHGPEMGVPSTSSVTGSVTMFADGGSEKDGQISRAEDIESGSSHLESVSDSPLAQIIGIGILEFGVLLHSILIGLTLAVDPNFKVLFVVLVFHQMFEGLGVGSRLAFMRLSPQYSYIPLVGACLYALTTPVGIAAGLGVRTTYNPNGPTASIVSGVLDAFSSGILIYTGLVELMAHEFVFNREMIESSNAKLCWALGCMMLGASLMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVS1</accession>
    <name>A0A401GVS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0902000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617234.1">
        <property type="nucleotide sequence ID" value="XM_027761433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVS1"/>
    <dbReference type="FunCoup" id="A0A401GVS1">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVS1"/>
    <dbReference type="GeneID" id="38783238"/>
    <dbReference type="InParanoid" id="A0A401GVS1"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE86321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="232" mass="26006" checksum="8F5F0F3AEF4A57F4" modified="2019-05-08" version="1">MSERQIRGTFIAIEGLDRSGKSTQTTLLAERLQRAGVETKFIKFPDRSTPIGKMIDAYLSSQTELDDHAIHLLFSANRWELASSIENALRAGTTVICDRYAFSGIAFSAAKALEGLSYEWCRAPDVYLPAPDATLFLNVSLAAAAARGGYGKERYETEDVQARVRAVFDRIGAEVEEAEGMWITIDADASTEEVAQAVWEFAEPFSHGTQLPLRRLWDHLQEDRRRNLELYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWD3</accession>
    <name>A0A401GWD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0903720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617406.1">
        <property type="nucleotide sequence ID" value="XM_027761605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWD3"/>
    <dbReference type="STRING" id="139825.A0A401GWD3"/>
    <dbReference type="GeneID" id="38783410"/>
    <dbReference type="InParanoid" id="A0A401GWD3"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="388" mass="42174" checksum="604B93DCF969DD75" modified="2019-05-08" version="1">MSTFKQQPHKLLVIPGPIEVADEVLYANAHPSMSHMSADFVPVLGDCIRMTRDVLYSTTAQPFIMAGSGTLGWDQVAANLVEPGEYVLFLNTGYFGEGFVDCLRVYGAHVDELQAKFGGAVPLSDIEQALASKKYKLIACTHVDTSTAVLCNVKAVAEIVKKTAPDTLIAVDGVCSVASEEIRMDAWGIDVVVTASQKGLGTPPGLSIVVASQRAIQVFENRVTPVAAYYASWKKWLPVMRAYEKGSAAYFATPPVNLVYAYRASLDRITKSSPTLEERFTLHREASKRIKDAVAELGLKQLPVDSNSSANGMTAIYFPDGFTASDIIPRMAQRDVVVAGGVHKDYKDKYFRIGHMGISVVDKERGDVEKVITALKESFAEARASKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWD8</accession>
    <name>A0A401GWD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0904150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617449.1">
        <property type="nucleotide sequence ID" value="XM_027761648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWD8"/>
    <dbReference type="STRING" id="139825.A0A401GWD8"/>
    <dbReference type="GeneID" id="38783453"/>
    <dbReference type="InParanoid" id="A0A401GWD8"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="634"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="920" mass="100955" checksum="5583AE51D1F3811D" modified="2019-05-08" version="1">MVVTKRAPAAPVLTSRTNSSQPVPRAKHKAPSNDPYLPEVSSPLTDGGTAHTQGQRVDPQSSVNGTGVSSPKKKDSWTKKRRGKGALSRLVDLLTRIFILCFCIYVAIVCPNDAQSKTSICRGLSEYRRLVIDPYIIPPFQHVLAHPSVAPYVEKAKPFADRAIRITKPFVQRANYEFVTRVVPQWNVRIVPLWKKYAVPQFSRIDAQLGPYCTRMEEEYERRLGPFVDRATHTMRLLQQKAHPYVIQAAHKTYDGYERARPYARSAWEKFKLIITRLVAFLGEYRRRFVDPHVQKIWERVKELSSGGSKVPTPTDVGEFVTARISKAAEDATDVAPSVLASAQASHSESFSIVSDAAETTPVAILSEVVSQVFSSASLAAEPPAAVSSRVSGVSSLVDATASSVFSAASVSTSCSSSLTDAFPSIVSSLPSEFASSASEMAHAAFSIDSSIANQPLSVSSVGDAASEGLTHASQTAEHAGSAVSSDVSTVTDQASAYTSSVARVPSASLTSASASSFPLVVTEAVTPVPLLKQDEDAELAAFYAELGLSDVLADSSSQPAAPVHTETAEERAAREEERAERQRQREVQTAKRRADIEGRHAKWESELSMAIDTKQKALRNTLAALRKDAVAELKDSQEIKEEVDSLVEEAEKLLRGAEKYLQTLEKETRKEEEKKTMWERVVEKVDEKFNQRLQQTETVVNGWYLGVINRELVEVRKVAEDVKDIADRGQADVGLDYAYLDDVTYSDWQRYHDIVRASDNFTADAHSIQDGTHSSPPPNPVLPAITDLQSEVQDIVVGFETRLRRVRRTGERAFASHEVVVEPKHHAADETVSILPIEDVDNVRSHADIFVPPVVIGRSKEEVLDALNRAAAQDGETTSPTEKREASQKAEELVQELVEDVDDDESIPDATPVPAHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWE4</accession>
    <name>A0A401GWE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SCP_0903810</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617415.1">
        <property type="nucleotide sequence ID" value="XM_027761614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWE4"/>
    <dbReference type="FunCoup" id="A0A401GWE4">
        <property type="interactions" value="557"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWE4"/>
    <dbReference type="GeneID" id="38783419"/>
    <dbReference type="InParanoid" id="A0A401GWE4"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="287"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="755"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GBE86502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="852" mass="95732" checksum="3EE6D1BB20B1664E" modified="2019-05-08" version="1">MIDKKVVGMNWIEIPAGKYNLITEGKRSHCQIELSVHTDKMKSHPADGEWSKIAPLRILSFDIECAGRKGIFPEPNIDPVIQIANMVTRQGESKPFIRNVFTLNTCAHIVGSQVLSFDDEAKMLEAWRDFVEQADPDVVIGYNISNFDLPYLIDRAKAVKAQKLPLLGRICGAKAQTKDTHFSSRAFGQRDSKETALDGRLQVDILQYMQREHKLRSYTLNSVCAQFLGEQKEDVHHSVITELQNGTPESRRRLAVYCLKDAYLPQRLMDKLMCFINYTEMARVTGVPFNYLLSRGQSIKVLSQLFRKANEVGYVVPSLKGEGTDEAYEGATVIEPKKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLSKGAIERLGLVKDRDYIQTPNNDFFVTSIKRKGLLPTILEDLIAARKRAKADLKKETDPFKRAVLDGRQLALKISANSVYGFTGATIGKLPCLPISSSVTAYGRQMIEKTKQEVEAEYCVANGHSHDAQVIYGDTDSVMVKFGPTDLPTVMALGSQAADFVTAKFVKPIKLEFEKVYFPYLLISKKRYAGLYWTRPEKYDKMDTKGIETVRRDNCRLVSTVISTCLHKMLINRDVKGAEDYAKQIISDLLQNRVDMSQLVITKALAKTDYAGKQAHVELAERMKQRDAGSAPALGDRVAYVIIKGVKGAAAYEKSEDPIYVLENNIPIDTKYYLENQLSNPLMRIFEPILGEKASSLLSGDHTRTIQIATPTVGGLMKFAVKTVTCLGCKTPLRANNSMKNGAVCHNCRPKLGELFQKQVSTASELQIRFSRLWTQCQRCQGSLHQDVLCTSKDCPIFYMRKKAQKDVEDANAVLERFDHEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWH3</accession>
    <name>A0A401GWH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exosome complex component rrp4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0904110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617445.1">
        <property type="nucleotide sequence ID" value="XM_027761644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWH3"/>
    <dbReference type="FunCoup" id="A0A401GWH3">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWH3"/>
    <dbReference type="GeneID" id="38783449"/>
    <dbReference type="InParanoid" id="A0A401GWH3"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="8">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE86532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="316" mass="35404" checksum="9B85F1A45ECE97D7" modified="2019-05-08" version="1">MVTFTSFPILHENGSDYSVTRHHPDVEDHLDINMEDDFEEGSHKLTFPGEPITSSQAFMRGHGTYVDNDEVIASVAGTIERVNKLVTVRAIRSRYNPEVGDLVVGRITEVQPRRWKVDANSRQDAVLMLSSVNLPGGVQRRKLESDELQMRTFFEEGDLLVAEVQAFFADGAMSLHTRSLRYGKLRNGQLVTVPPVLIRRLKSHFLSLPCGVDLILGLNGYIWISKHMKQTEQEGEDAFYAEAVYSNKNDYIDDATRDAISRVSNIIRVLATHFIPLTDTLLLEAYAWAVEQEGDVKDLLQEEVGDALAAGVISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWV5</accession>
    <name>A0A401GWV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="15">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0905430</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617576.1">
        <property type="nucleotide sequence ID" value="XM_027761775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWV5"/>
    <dbReference type="STRING" id="139825.A0A401GWV5"/>
    <dbReference type="GeneID" id="38783580"/>
    <dbReference type="InParanoid" id="A0A401GWV5"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 15 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="170"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE86663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="414" mass="44553" checksum="A948BF889CB7D540" modified="2019-05-08" version="1">MPAPSKQPISGLKSIKRDFSSAPLPSASQNSSLSASDASAIPWTPSPPQQQLPGMAQRLKDIQDALSGHAVASEKTLSGTSSASSSQAFRGGPPGSLKRSAPSQDPPAKRRQLPPNWSENTESTTSRTFGSSRVANAPLVVSAASSGAVAKPAPVFLSQEQQHILKLVQDGQSVFYTGSAGTGKSVLLREIIKTMKKKHPRAIDAVAVTASTGIAACNIGGITIHSFAGIGLGRESAEQLATKIRKNKKATGRWLRTQVLIIDEVSMVEGELFDKLARIGSIIRKRVEPFGGIQVIVTGDFFQLPPVTKSTGVKFAFEAELWGQTIKKTFNLTRVFRQKDPEFVSMLNEMRLGCLSDESIKKFKRLEREIIYEDGLGATELYVFRASVLSHSANCPARIVLLASPAAKRWTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWW2</accession>
    <name>A0A401GWW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0901330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617167.1">
        <property type="nucleotide sequence ID" value="XM_027761366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWW2"/>
    <dbReference type="STRING" id="139825.A0A401GWW2"/>
    <dbReference type="GeneID" id="38783171"/>
    <dbReference type="InParanoid" id="A0A401GWW2"/>
    <dbReference type="OrthoDB" id="16729at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="279" mass="30964" checksum="F4178E6DF0D51832" modified="2019-05-08" version="1">MASSVIGSVFLGDVQRHRLLSSSSSTPPSSPPPHISPSTMSSLYDLDLDIPEEAPKTSGPPPSVPPVLSLDLRIRWLEALLYGAQQDGRERGGAKAHELKKGETLMRRAEELQRKVDGIVQSNDGLKKFMEHYDQHAHLLTPAFALSGTLPTAAPTYENMSLSELEAFLVEMEPDIRAADRDLREISLLESKGVTGAGKLADYKILQPRLEALVQAHTEDLEKAADLEKRIAALMDRYATSVDTLSELFVAWDDAVREAEDHVAKLERDREERRRLGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWZ5</accession>
    <name>A0A401GWZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0906360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617668.1">
        <property type="nucleotide sequence ID" value="XM_027761867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWZ5"/>
    <dbReference type="GeneID" id="38783672"/>
    <dbReference type="InParanoid" id="A0A401GWZ5"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48147:SF3">
        <property type="entry name" value="MYELIN TRANSCRIPTION FACTOR 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48147">
        <property type="entry name" value="PROTEIN CBG23787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="854" mass="95192" checksum="AC8789B7B3805AA0" modified="2019-05-08" version="1">MVVRSKGRAAKEIHSSVLLFPFLLSMSTDYAGRWRDLVRNALPEWSRASRKTYQDVEPLSYHDPHPLSGTLKRASSDLPHPAARASKRPVIDWSAGDSLDVVSSVPAVSNQIWNDATKAIASPPEQDMDILHSTGNRVNSGEGDAANVIASPSDTPGVHQHALSQASAAVQWTDSPIQSETRSEVPATSSGNLSEKYTCSNEQVLFPAQPVLSSDVPASLTVVECKEQPVSLLPSTSVTSPSGIISAPPALTELSTFADNDENLIWSINMQLGDSDGSGDSQTEDTEDEDEEGDEEDEDGDEGEEEDEEAENEDEDGDEEEEDEGYEEDEEDQEDEQDEEDEEDEEDEKDGREDPSNDDSDGNNDKVVIVGNNSSDDDEDSNNSDSVGGGGSDDRREFSNSTAEEKESQNDGMAIDEEYDHGYVSDEMDLDTAADGVASVAAGSAPQSGTNKRSIFEVNFLESAPPASYPATIPRGYPHLNFCVLSIDSVFYVLENDAFRDLSVGNQNAPATKKDIQALITMQQGLAQEIARLRRIPESSSAEDSSSCTQKKYRGKVAHRPGPKLNVQSKIRLHALEMLGRETKRSPILGASDKEVALFERHKHPGPSKEYFRPHFNGTPRTPWNRRLAEVFTNDFISLGWSKRKDFSEIFNMFCTHFETLNKQYKRQTRSAKKPSQAEEDKTAEGHRDQRRRNLRTRRFEAIGQHIDVIRYKDLWNTIPPGAMSGDESDHRSGKLRYVVTKLPWRSAEAERWLCTFDLLHLKTRFHDNGKPKRGAFPHHRIRGSSRIERNDDPVSGLPRNFYDATWLSDQSEDHIRALDIQPSVDLTLSQDCLREAARFARITNRRTPPRPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXG7</accession>
    <name>A0A401GXG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1001010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617772.1">
        <property type="nucleotide sequence ID" value="XM_027761971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXG7"/>
    <dbReference type="STRING" id="139825.A0A401GXG7"/>
    <dbReference type="GeneID" id="38783776"/>
    <dbReference type="InParanoid" id="A0A401GXG7"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="188" mass="21803" checksum="545C1B6DE08F1E58" modified="2019-05-08" version="1">MDCPILVWMLYLNREMNKEDYESCYTVMQECVTHANVRYAPDGRETYRQILAYMLPLLMMRHRRIPRIKWRDHEGPNGKHYIEQDFDAMHSNRVRSMIGYHLAYDNNLVGMVMTQGKQRDVINIGLGVKQLAVSPPDISVGAYAESFYHKLTPLELSFIAPDHGETTVLRRLCLLLALKQSSTSNTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYE2</accession>
    <name>A0A401GYE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1004260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618092.1">
        <property type="nucleotide sequence ID" value="XM_027762291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYE2"/>
    <dbReference type="GeneID" id="38784096"/>
    <dbReference type="InParanoid" id="A0A401GYE2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="10506" checksum="4DB6144ADF93E16E" modified="2019-05-08" version="1">MADLPPMLAALAAAVPQESFVALQPILEELHHRISQISTEAATTQASILNATQMQNVSTAHFTVQAPPSPLQTSAPSIHPASIKADLPIFRGQDLDDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYG5</accession>
    <name>A0A401GYG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617797.1">
        <property type="nucleotide sequence ID" value="XM_027761996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYG5"/>
    <dbReference type="GeneID" id="38783801"/>
    <dbReference type="InParanoid" id="A0A401GYG5"/>
    <dbReference type="OrthoDB" id="2590746at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="672" mass="71777" checksum="F407F107D25D4853" modified="2019-05-08" version="1">MLSSLLPFLPSAFTSADKSPPPSQESPDEQQDIHPKEMPGTTVVDELGVKKRKERTHESFIVVRPPPAKTNHPLNLQVQLVPPSGKDPARPLDSGSTQDLGGSLSRTSSNRSDTSMYSTYSSSGSISTVASSSSSTGRRMIIPLYNLQAHNVMQNVIVDAGTDAKVAKFLKRGLEVIGLAVLEPVEVWGSAAAEAWSVRPPHDGAKRNSIDFSGAGLLSPDLAHTPTSSALSLTSEDGYQTLVVPSSAPDRATPKRLFGRLFKKKDGSSMLPKPPPSPVTSISSIPAAPLSKRSSMHVQPGSLAAGEPSGAILQPPVLGIQPLLSSATIPPRGRPTRYVWVVRRWLKGTQESLLDGVKDMLQQDNTRPGNGLEGLVEVRFEWSRGKSGKSGRGRRRTEDSEVSPELRERGERIGALSKRNSIGRSSTPSTASLQHQPPSHPSPPLSRTSPLQSAPQSPSRTQSPRTKRTALSPAGGRRSLDSHRSVSPHPPASLLTNNTSTEDDTHGDNADESDPEDSETPWTCTLVVRRLAPMRGVELGVASAQPPSICLKVAALVPTPHHPKVIALLKVPFPLPDIEVEHVRLRKRIVTPAGVARPAPVPEPVANGKSGGSGSGLGKGFWAQQSQREGMMLTAEEIKDVVSSTGLWLVVREAFGGVGRVSRKGDGWRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYU1</accession>
    <name>A0A401GYU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1100080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618246.1">
        <property type="nucleotide sequence ID" value="XM_027762445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYU1"/>
    <dbReference type="STRING" id="139825.A0A401GYU1"/>
    <dbReference type="GeneID" id="38784250"/>
    <dbReference type="InParanoid" id="A0A401GYU1"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="102"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="577" mass="64041" checksum="0A6768A11E629A11" modified="2019-05-08" version="1">MTDFIRFLVSGDKARFKDGELDVDLDLVYITDRLIVMGYPAAGIEGLYRNRREDARKFLEHRHGKDFWVFNFCPVKENSYPSSVFNGRVSRYPFPDHHAPPLAMLALVAREMHAWLDSSPERVAVLHCKAGQGRSGTMACSYLLTLTNTAQLEAPKDSNFSKALATTRAEEVMNAMPADEHLSEDCPVESIMIGEDPIKKELVKSSAENAQCANEPAANLTQVLKLHTSRRMKPDSSKKPKQGVSIPSQRRWLYYWSLLLAREGPPGFWSAHGSPQTRLVPKVRLTQIKLRMSELSGTKANLIRVANAILDRTTATARGVGISGGRPRVWASLARYDDEFVGHIEDWEKYTRDDSGNMGTRRIDTDCRAAETFADALKERKWDNAKMIKSFARLGTVGNGVVQNGEAQTDGKTVTQLLEPLTNDSWGVLRDEIEESPGSAHTEGSKLESEETSLYDVPSSPRSGGGIVLDAQREVRVKLFMGQVFMAWFWFIPAFHMPQPQSGGQDARMLLSKKEIDFPLGIGSSIVDVEVAMEWYPEIAEAVTPSLLQGNVRSVHGRSEPSGITGTSTASTRGGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZH5</accession>
    <name>A0A401GZH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1102540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618490.1">
        <property type="nucleotide sequence ID" value="XM_027762689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZH5"/>
    <dbReference type="GeneID" id="38784494"/>
    <dbReference type="InParanoid" id="A0A401GZH5"/>
    <dbReference type="OrthoDB" id="2667096at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="144" mass="16340" checksum="B960282B399051BC" modified="2019-05-08" version="1">MCNDILDWALLKIVTLVDKECNTPPTIPHPRLPRARTPPPLSSLLDMQDSCDDSADHWAPRHGLIVIKVWVPSTDDIWAFRVPEAESLAAFRARVAEKVGFAVRLEGKNARTRARMLKEEGTFRTWVRGRVRSGRNHLLTAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H044</accession>
    <name>A0A401H044_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1200200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618708.1">
        <property type="nucleotide sequence ID" value="XM_027762907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H044"/>
    <dbReference type="FunCoup" id="A0A401H044">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H044"/>
    <dbReference type="GeneID" id="38784712"/>
    <dbReference type="InParanoid" id="A0A401H044"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF2">
        <property type="entry name" value="SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="251"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="550" mass="60988" checksum="A428DA13FF6157FF" modified="2019-05-08" version="1">MRSACARERVDVNGESGLQTLFTTEWPVRVHAHEIIWEVDNAITAALHLGKLPPIRDRVGSMQSTSTSPTGRGQLAAYRMVALLHQYPTISQSSCSKTFAPTMDAQEAKEKGNAAFQHENYFEALEHYAEAMQSDPTNHIYPLNRSMANLKLKRWSEAEADATAALQLSPVTVKAYFRRSVARREQAKFEGARRDIQDYMDAGGDSKCADKELVKISAAESARTNESTAGLQNMAELSLASVADLNANLPGGFTLRPVNGKGLGAFASRPFRRGDLVLTDPPLYIVENPDNGGRIHQGKVITAVKRLSAADKQVFLSLMNVYADTGRFPNPILGIHDTNAFQVGGYDSALCIVASRFNHSCSPNARYSWHAASGRLRIYALRDIAVGGELLVSYISSRRVYGSVFRERQQRLSMSHGFTCSCATCTLPKKDRLSSDQRRKELTRIWESIPYYNPGQTADRLRAIVRAVRLLDEEGYAADADDFTIDAAGICACHSDWASVEYWAMKTYETRVAEFGEDSDRAAEVRSLSSDLRRHPDAGTQRKQTFLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0H3</accession>
    <name>A0A401H0H3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Transposon Tf2-6 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_1201440</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618831.1">
        <property type="nucleotide sequence ID" value="XM_027763030.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="term" value="F:endonuclease activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
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    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="259"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="813"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="1112"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE87918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1166" mass="133642" checksum="91B8807509F6DB76" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGKDAKWPPKPTVEDAPDEGASIFKEDGLSELITTETSPTSFGHSESIREIMTDNTERGELPAVRNDTKPDDPPSEPPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKTSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPVTFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVRTRRVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFVVESDASKFATGAVLRQADINGDLHPCAYISQTLNSAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSRRNGLDDSESDNEDRILLPNALFIRSISPTLFDEIRNHAAKDLIVHEALEAIAHKGPFPMKSSLSDWEVRDGVILYKGKIYVPPSETLRRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHSQTDGETERVNQELEIYLRLYCGNNPETWADRLPDLEFCHNTREHSARKMSPFRIMMGYEPRGLPSIFPSTNIPSIESRLDMLQKIRLEALAMHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYVNPPPDVVDNEEEYEVEAILNHKTHRGHLKYLVKWKGYSSAENSWEPTHNLQNAKRILDAYKRTRGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0L5</accession>
    <name>A0A401H0L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Pre-mRNA-splicing factor CWC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_1201550</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618842.1">
        <property type="nucleotide sequence ID" value="XM_027763041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0L5"/>
    <dbReference type="FunCoup" id="A0A401H0L5">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0L5"/>
    <dbReference type="GeneID" id="38784846"/>
    <dbReference type="InParanoid" id="A0A401H0L5"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="148"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE87929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="367" mass="41455" checksum="FA0BDFDED0A32EF1" modified="2019-05-08" version="1">MSSNVDSAETQTVVKKQKKQKPARKQVKPGEVEKKEAPQTGKEYNIWYNKWAGGDREDSYSNKTKSQTRCNIRKDSGLTRADTTGVKYCCLFFSRGCCPYGWECEYLHTLPDASKALPDTSKDCFARDKFSDYRDDMGGVGSFTRQNRTLYIGRIKETGTGVETEEVVRRHFKEWGEIEKIRVLQYRSVAFVTYVSESHAQFAKEAMACQSLDNDEILNVRWATEDPNPVSKVTEKQRLEEIGREAIQARMDPRIVDAMRAVRALEDGDGLDDEEETVDGEGEAEPQAKRRRLEIEDARDTPPEVEPVPKQEQPQQPTGLLSADTLEGLKYFAEIRKRNALANNPVKVAAVPPPRGLGLADYGSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3B6</accession>
    <name>A0A401H3B6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619814.1">
        <property type="nucleotide sequence ID" value="XM_027764013.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="38785818"/>
    <dbReference type="InParanoid" id="A0A401H3B6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="191" mass="22279" checksum="A94DBBFE6BD6EE12" modified="2019-05-08" version="1">MDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNNDFLSYGNWKDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASQFDNQWRSAQIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3D5</accession>
    <name>A0A401H3D5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027764036.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3228777at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="79"/>
            <end position="151"/>
        </location>
    </feature>
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            <begin position="167"/>
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    </feature>
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        </location>
    </feature>
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            <begin position="531"/>
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        <location>
            <begin position="821"/>
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        </location>
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        <location>
            <begin position="904"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
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        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
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        <location>
            <begin position="938"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="986"/>
        </location>
    </feature>
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        <location>
            <begin position="1007"/>
            <end position="1021"/>
        </location>
    </feature>
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        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
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        <location>
            <begin position="1103"/>
            <end position="1117"/>
        </location>
    </feature>
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        <location>
            <begin position="1201"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1308" mass="140860" checksum="1B489E9697679D92" modified="2019-05-08" version="1">MATHPQPSGPSSLSRLSRLGIAFGLKPGPSTAVPHINPSPTEDWYIPYNGPYEKPHSLSAPHDRDSWGNLVSGWLVDEDDDKRGDRISRPIRARAVSSASRLSVASGDLETTRRSLSTRRAAGASQVGGVGEAPMPMRPSQDHPRPPEVNRNSFANILGFRHTSKRGLSLHQPASAEDLRNASSSRVHRYGEAEGNGPLPRPHPYSYASGLPTDASSSASAAKARPSPTSKFSITLLEPMIRKSSGPAMPNYLKPAHRPPGRSLKVSTSTPNLRRQRGSPSPFSVALPKGKQRWLSAETWCDAILLPRPRFTMRVTDTGANVASSGRIVSPPGSPIWPPGTGPGEQVESPTEAVSVYERGVQESTQRQRRDVRKSQSASQLVFVRPPSPEIVEAPRPVVPLPPGPLVASSSRPPRPKSFAWDDLAIPSPVPSLTKVLEDGRQLEVERKEWQSLATRSFQNKRARSVSRARAKSLTSSRVRLRDTPTTLDLLAERTLLGGQTRPPTVHIRVQQSLPSDENATGFGISTFSSATHTQTQSHSHSHSHSNLHSHSRAARSHAHSNSMGTSASHPASDDSFMWVAPGAPSGGHKRTQSLGKSALRIVRNTANSAANFCGFSPGDPREPGIASPVYENGCLEGALRSEGTRVIRLRDQIRMEERNGEGEGVVLITPAPASNVGLRTDAAGPSRMNGISPTPSGSGEGVGIAISTPPHSDDHHERLRIPAHPYAQVGNYVYRQPIVVDKTAASVPSVSQADTAAVEDGLNRHRQPVHPYSPYAKGLHPYAVSGASNARQHPPAASNTSMFAEISTGHIREILPDEIKYSPLTPTGPSPPPMPSPQDNQEANASERSEHSHPYGPQSRRTSEWGFADALTHTLGRAKSGDNDEMDGLTPPSMSVAQILVSGPQQEEPPPVPSVPIPKQTSSSSRSRIDISREPTHLSNHTVSSSMGSINPAMFRRTHSAHSSAFLHGNSSRSSPGMISHDSSPPLSPRPLNAPDDLERFRDLFYHPPDRSRTPSDDGIARPVPSRQASGTIPIDFGSERTVSGLTTLARQLSEDLEELRDLARDSYESGEATSPMWGRRFGGLHGERPDDLRENPNVVLSQSPSGSNSSPETSSRLGLPLDRSLSLMGPTINVPEDVASSRASSVLESPLQEEEEAEESLRLGTVEVLSTPPPFETTHRFSTRLSLIGYARGGRDEPQTVSLRPSRISSQPSSLGAPPSSDAARSSFMTADTNVSRMSGLSDFPAPPTDVTPENMSVLNTYFEERPQSQSDKPFNTSLLSRPPPTLVRESSRGTFGRQNDAGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3M3</accession>
    <name>A0A401H3M3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1500160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619927.1">
        <property type="nucleotide sequence ID" value="XM_027764126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3M3"/>
    <dbReference type="FunCoup" id="A0A401H3M3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3M3"/>
    <dbReference type="GeneID" id="38785931"/>
    <dbReference type="InParanoid" id="A0A401H3M3"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="261" mass="27469" checksum="9E68ECFEDA0CE01B" modified="2019-05-08" version="1">MSAEFNPRVAIVTGAGQGIGRAIALRLADDGLDIAVNDIASNSVKLDEVVGEIQAKGCRAIPLIADVSVEAEVKTMVEKAVEELGGLDVMIANAGVGGGAKPLTEMSTETWDMVMSVNVRGTMLCYKFAAQHMIKQGRGGRIIGASSVLGKKGVAKTSAYSTTKFAIRGLTQCLAQELQPYNITVNAYAPGLILTQLTVFEEDKYFGGNHGAALKHLLGERPDGPEATPEVVASVVSYLIKPEAHFITGQSLSVNGGIYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Q6</accession>
    <name>A0A401H3Q6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1500700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619980.1">
        <property type="nucleotide sequence ID" value="XM_027764179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Q6"/>
    <dbReference type="FunCoup" id="A0A401H3Q6">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3Q6"/>
    <dbReference type="GeneID" id="38785984"/>
    <dbReference type="InParanoid" id="A0A401H3Q6"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE89067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="255" mass="26867" checksum="39A5C6FFE54D7CCE" modified="2019-05-08" version="1">MSIARIAIVTGAARGIGEAVALRLANDGLDVAVTDVSASAESLNAVAEKIRKTGRRAVAVTGDVSKESDVKAVIDKVVDSLGGVDVMVANAGIVMNKPAIETTLEEYNRVMSINATGIFLSFKYAALQMIKQGRGGRIIGASSLAGKTGMTNLSAYSASKFAVRGLTQTCALEWARYNITVNSYCPGIIYTPMLTESKKVEDDKDVPPIEAVRLQKSTPGAQPSVIGNLVSFLAQKDNNFVSGQSININGGIYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Y3</accession>
    <name>A0A401H3Y3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1501160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620026.1">
        <property type="nucleotide sequence ID" value="XM_027764225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Y3"/>
    <dbReference type="FunCoup" id="A0A401H3Y3">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3Y3"/>
    <dbReference type="GeneID" id="38786030"/>
    <dbReference type="InParanoid" id="A0A401H3Y3"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="401" mass="44001" checksum="C3910D271EC306FB" modified="2019-05-08" version="1">MARNLFSVPIYFIVFRETVEAAIIISVLLGLVEQIVHGEETQENISEATGTSDSLNEEQKEKSAAELGQTPEVVEPVTAESDQDSQLSTKRLIRKMRIQIFFGSFVGLFIALAIGAAFIAVWFTQASNLWAKSENLWEGIFQLIASILIFVMGIAILKMDRAKLKWRVKLQRAFSGKHIGRGERAGKWMLFFMPMITVLREAMEAVVFVGGVSLGQSAVSIPIAVVVGLISGLGVGYLVYAFASRTTLTIFMVVMTNLVLLIGAGLFSQSVFQLQAHAFTLLVGAEVDDTGGDGPGSFDVRGSVWHLNCCNPENNLNGGGWMIFNAILGWTNSASIGTILAYVFYWLAVITALVRMKYKEGRTKIFGRESAAAVRRRERTEQREQAERTALAQAVQSQGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4P6</accession>
    <name>A0A401H4P6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620262.1">
        <property type="nucleotide sequence ID" value="XM_027764461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4P6"/>
    <dbReference type="STRING" id="139825.A0A401H4P6"/>
    <dbReference type="GeneID" id="38786266"/>
    <dbReference type="InParanoid" id="A0A401H4P6"/>
    <dbReference type="OrthoDB" id="3218552at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40296" checksum="45532C7687E3AA2D" modified="2019-05-08" version="1">MVHYRTMLRVPRRGVCMSYLARLRAGVWCCVESGVGAESAVGDRLRVGIRKGLFALPEHAHTSVICVGPGTGIAPRRALIEERVFAGSTEKTLYFGCRLAKNDQHYYSEWEAHVWRELTYRVIYSRNGLPGGRSDVCAFDRETRPTMVCGDGNTQKFGNVDGLRVTGRGLLFVSATVMPWPNRVLAQFALVPPNPRENEYYGPYNKLLNYLFPPDSPYTVVPQYLQPASAKGIEYVVLFEIVVENRPVFILEVKEPVDLEYVSARESADDQIRHCIEDLVGRCPIPTLHAVSAMGTRLCFYRQDTGPGAGPILPIGIARHPERVNDAAPAERWDCDILDPEGEARFRAVVEEIKVGCVDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4S9</accession>
    <name>A0A401H4S9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620350.1">
        <property type="nucleotide sequence ID" value="XM_027764549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4S9"/>
    <dbReference type="GeneID" id="38786354"/>
    <dbReference type="InParanoid" id="A0A401H4S9"/>
    <dbReference type="OrthoDB" id="3063971at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="60153" checksum="511AF4BC1D479BFA" modified="2019-05-08" version="1">MDSPQDPVTEELGDSPCELRLRKDNIERLFESQDLRTLEVAVDRTQHQLDELQELHSRLRAHLELVSSLAAPIRRISEDILRQILICRWSDTNERDRPLFTLCVASVCRAWREAVIDASVLWSTIPVDIALPPPSALPLFVEHSRSRGLEIHINYLHSDSDSEEDSGSSPDHDNVMSSRMQRQNLTAVLKLLVPHLTRWKSLSISLPFIDLKKEVLASMRGPADLLEELVIYSRGKSNPLPADLFPAHFKAPRLTMMLLDSWQLPKTLVFQSVLPALRALRLTRPKVPNRMSLMQALGPLRHLRCLELICPEFDNISAVDYFPRVPLVNLKKLLVIALEPGAVRALLSSFSAPRMARFNYIHPIFDNSEVPLVMEHPQAFPSLHTILIDARCSYPPSMGAVSRWTQDFQCAHINLVKNHDHIKEFVACARNMKDRLFFPGLSSVIIHSENHVTVKLLRDLVRARGRAAIPSHLQGCDSPSATLKELEVYTRCRLCPQDNEWFKNNLESFSWSFVETILDDTIILSFAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H516</accession>
    <name>A0A401H516_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1601020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620353.1">
        <property type="nucleotide sequence ID" value="XM_027764552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H516"/>
    <dbReference type="STRING" id="139825.A0A401H516"/>
    <dbReference type="GeneID" id="38786357"/>
    <dbReference type="InParanoid" id="A0A401H516"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="620" mass="67102" checksum="B16E49588F595EA9" modified="2019-05-08" version="1">MPADSQYSHQQQHQPPWSQQSSHLLHPIHTQQSAFPSPSSPTTSLSDHHYPPFYSQQQSHSGEGLGDRVVDRSHTALSLNLSSLTVASPTSLSPVGPHSSTHAHVSPITPISPAGAIMHTHQQLSAQHAHLQPFQFSPDHDSAYDYGAPRRLTSSRSSSSSDRSVPRKRSFTTPLATSVEEPYEHASYEDVDMGYALDPEGSPVDGSTSGGEQDDQLKPLSSTSAPGSTMSLTLLGKPLGTNNFVTKLYQMINDPKSAQFITWTELGTSFVVSNVGEFSRSILGSHFKHNNFSSFVRQLNMYGFHKINRTPRAQRTSTDVQTWEFSHHKFLRGRPDLLEEIKRKALEPDPSLKHRIELPGEVAAQLSQVREDNRRLTMAMHAERSKVDRLAAVTKVMYDTLTKAFPGGVPIAFPNDILETADSPNIYITSPTNAIPSSNSFPASLSSLPNPSLHSLHSLSPGSSPTASEFPSHTHTPHTLSRQHSFQHIPYDAMHTHPGLTHVSSARYEAALSTPLPPSPGGPGDAFDERVGAKRQRTGPPPAGGISAGGEKKGSRARSDSAPLGYGFGSGWTQTRPRSGSGLGSRMRRDEGPIPNLTGMRGHALPILSIPSPGKQSPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H573</accession>
    <name>A0A401H573_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative CDP-alcohol phosphatidyltransferase class-I family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1601910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620442.1">
        <property type="nucleotide sequence ID" value="XM_027764641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H573"/>
    <dbReference type="STRING" id="139825.A0A401H573"/>
    <dbReference type="GeneID" id="38786446"/>
    <dbReference type="InParanoid" id="A0A401H573"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000017">
        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="31748" checksum="9C40F0D91BB42C88" modified="2019-05-08" version="1">MFARLSIPSRYSSYQSLRGDLSGLQFPTYSHSHWRARRCRCPHSLSKPLVRYTVRHFSAQRPPASSDSDKPAQFVRRTLLRENIYTWPNLLTVSRILACPVLGWSIVHDNFHLATALLAYAGVTDLVDGFLARRFNMGTVLGTILDPAADKTLMTTLTVTLSMRGLLPVPLAVIILGRDVLLSLSAFYIRYTSLPHPKTWSRYWDFSIPSAEVHPTVISKINTALQLLLMGVTTISPLLSPLDLGFALQALQWIVATTTIWSGASYLFTKDAVRILSAKRKPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H664</accession>
    <name>A0A401H664_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1702400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620827.1">
        <property type="nucleotide sequence ID" value="XM_027765026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H664"/>
    <dbReference type="GeneID" id="38786831"/>
    <dbReference type="InParanoid" id="A0A401H664"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="179" mass="20735" checksum="52C8677F949D1DB4" modified="2019-05-08" version="1">MSAQSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDNFTKVRWEEGLRREMFAVRGICGDLASAPISIDVKAIPRPTTLVPRPKNLLEDSPDYWWKWDRQVGPAGSPMEAWWYKLGDPWEKVYTVSESTLVQLEQLHVRVVNLTSWLHERTDQNLDVVLEKLQEATRQLRELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H727</accession>
    <name>A0A401H727_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_1900400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621104.1">
        <property type="nucleotide sequence ID" value="XM_027765303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H727"/>
    <dbReference type="STRING" id="139825.A0A401H727"/>
    <dbReference type="GeneID" id="38787108"/>
    <dbReference type="InParanoid" id="A0A401H727"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="340"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="573"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE90191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1036" mass="116634" checksum="E79CFD8C77F90B26" modified="2019-05-08" version="1">MAILRERGVLKYVDGTSEKPKPVDAATLTPEEMAATKKWIEGDQKAQTVIELLLSDLQMIHITDATTAVEMWNQLKLVKEASGQLGIMAYRRKFYHTVATEGSDIAAHITELHRTQEQLHTMGSKVSDDEFRTILITSLPESWDQFTSAYLAATSQKDTLPTFMPLEASSITGIGDQSIRALGRGTVEVNSRIGDKTFTFCLKDVLYAPKATNNLVSLTRLDEVGGHFDGGDGGIMLRESGGHAIAEGRKIGRLYLLDMRAKIATPMNEHMNVAHEDNDSWESWHRRYGHLGITGLERLYKEKMVEGLTIDENSMPLTQCEACVQAKQARRAYPKEAEDRFQMPGELTHSDVWGPACVVSIAGSRYYISFTDDCTRRCQVLFMKHKSEAFEKLKEYLTFIERRFGHLPKIVRVDNGSEYINKNLKGWCCEKGIELQTTAPHSPSQNGVAEQFNRTLLELARAMLITKNLPSFLWAEAVAYAAYLQNRAPTKALHGRTPEEAWTGNKPNVAHLREFGSDVWILTEGQNLSKLEPKSKKHTFVGFADGPKAVRYYDAGACSIRVSRNFVFADAPKPASNVPVHQFNDGDRLPLEGESEGAVKQQPPTSASKPASVPVKADQSNKKHDGNHITEEDLPPKMQESMRERPTFLPAPPKIPLCRTTHAMQDHDYQKMDNPHAQPVKSREPPGVLKENALGESAKVAVTPEDFKEIAQVLLTKAQASPEWSEWEKAVKAEYDQLQGMGTWELQDLPKYRNAVGCKWVFQRKTNKESQVVKYKARLVAQGYSQIPGMDFLETFAPVVRLESIRAILALAVVNNWEIGQMDVKGAYLNGDLQEEIYMRQPEGFDDGSGRICRLRKTLYGLKQSGCKWNRKLHRELMELGYKRLEADPCVYLWERKEGEVQIITVWVDDLLLFTNSPKLMEELKRDLQDLFEVTDLGEPQKIVGIEIERDREAGTLQISQQHYIESILKRYQFENANAVGMPLDPNVVLTVEDKNEEADNRLVGGYASMVGSLIMPTTCPLDSGKMRSTVPRRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H772</accession>
    <name>A0A401H772_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1901010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621165.1">
        <property type="nucleotide sequence ID" value="XM_027765364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H772"/>
    <dbReference type="STRING" id="139825.A0A401H772"/>
    <dbReference type="GeneID" id="38787169"/>
    <dbReference type="InParanoid" id="A0A401H772"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="52555" checksum="CD65C1A2E21C3D0A" modified="2019-05-08" version="1">MCAIFRGLRRVVDLAPWCVQKCLELVYLLQIDRDYEYTSLSTMIPHAPTFPPELCDMVIDYLYDNESALEACSLVCRAWLQSTRYHLFHTVRTRESIEGRGASNLSRILSKRHAKGILPNIHELRILASDSAARTELRPPIYSPKVSTQDVVRLISQLPRLQTVEICGVVLDGRYCNRGKSVTPISLDTLRLDRICCRNNLVDDLLSILRPFSDIQHLEVKTIKSSYWYLEESETRVEETLNKVSQVLPPHLRVQTLVVRNCTLGCLLLCDIMRKTPSVQTLQRLDLRIECLGDITALGALIKATGANFRTLCLDISSLNWSADVFDWKKLNLTDCPSLEAIHGMYVGPKFFHNTSTSYLNLLCTVNPSSLSLLTFRFRVNNSLSDLKAVDWKRMEMVLSRFRKLEMVGLCVQDNRIPPQNEMVECWQLLKRLLPGRGQRGVLNFQYSSPVVATDHWVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5M7</accession>
    <name>A0A401G5M7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0103340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608372.1">
        <property type="nucleotide sequence ID" value="XM_027752571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5M7"/>
    <dbReference type="GeneID" id="38774376"/>
    <dbReference type="InParanoid" id="A0A401G5M7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="196" mass="21755" checksum="3DC4A0534657AF2F" modified="2019-05-08" version="1">MDASVILRKYTLAEALLRIEIFTEPFDPILWKAWAVRMHVLLVLMVQAQSEAASVGIILPLPRDIPVLAQVEIHLATAHTVEGGRRMIPRIADHLPAVIPHGLTARVLYDDPAVREDFGLGHPPDGLPDTGTLHLRVETLRNAARKLYDVMRGITGRRELADGTLRRLRITVEELEVAFGLVACPPPITSFQLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6L1</accession>
    <name>A0A401G6L1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0106800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608711.1">
        <property type="nucleotide sequence ID" value="XM_027752910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6L1"/>
    <dbReference type="STRING" id="139825.A0A401G6L1"/>
    <dbReference type="GeneID" id="38774715"/>
    <dbReference type="InParanoid" id="A0A401G6L1"/>
    <dbReference type="OrthoDB" id="2626014at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="263"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="589" mass="64045" checksum="0862B8C825A1833D" modified="2019-05-08" version="1">MTSLPGYVIQHPSRVFLSTTTALGALALSPSPPLIPLILLLATLHLHLYMLIPRHKVLSHGSVQVLFLSGAAGLAHVGPSFQALSTPAISFVSLGVISFISSSFALLSIVLSYYGGRLTHSHWTQALLFPSIWASTWGIVAYSSPVGRLVTWSPVVGLGYYNWMREIFGQYGIDWVVAGWAVVIAAAVGQWLVGPAGDADVASSEPEHLISLPLEGLPGGRISKDSKSKLRHMLVLAGFLVILTLPSFFMSSLPLPVNSPGITPLGVACALPYPHRSGRRRDPLTLLDFIMESQRLQSQSNIVLWPEGAVRFDTLEQKQRAFLMAQRSMNAGRYYAISFEEYVPPQPSDDQGVAGIRRNGLVLLGSTGPPVFEYYKRKLVPIAESFSLTSSSDPPTIFNLELGPPKSWNKTTWAPGNHTRPIPLTASICLDFSSSSAFDGLPSRPALILAPARTWHIDVGYAMWQQARARAEEIGSTVLWCDGGEGGVSGIAGGGMHEIVQVGQGSWTRTIGVHWPFDQRLTFFARGGDYAALAAIWAILGAGWGIEFLKITGCHNGHRFGTWIMGQLRKLRALRSPHERDQEILIDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6N5</accession>
    <name>A0A401G6N5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0107050</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608736.1">
        <property type="nucleotide sequence ID" value="XM_027752935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6N5"/>
    <dbReference type="FunCoup" id="A0A401G6N5">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6N5"/>
    <dbReference type="GeneID" id="38774740"/>
    <dbReference type="InParanoid" id="A0A401G6N5"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="32"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="392"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE77823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="532" mass="58088" checksum="E73FDF55230FA2FA" modified="2019-05-08" version="1">MAQPAIESRLEWFATLTTTHAAVPTEETKFQRKTAIIATIGQVNTVERLTELRRAGVNIVRMNFSHGSYENHQKVIDNTRKMVAADPESRPVAIALDTKGPEIRTGAMRDMKDIPIKAGHEFIVSTDPKYSEICDDKVMWLDYKNITKVTAPGKLIYVDDGILSLLVLSIDGTNVHVRALNNGTLSSRKGVNLPKTDVDLPALSEKDKSDLQFGVRNGVDMVFASFIRRAEDVRHIRQVLGPDGANIKIIVKIENEQGVANFDEILRETDGVMVARGDLGIEIPASQVFLAQKMMIAKCNMAGKPVIVATQMLESMTYNPRPTRAEVSDVANAVLDGADCVMLSGETAKGSYPIQSVLMMAETCLLAEAAICYPPLYDDLRACTPRPTETVETVAIAAVAAASEQNAGAIIVLSTSGNTARLVSKYRPSMPIITVTRNQQTARQIHLHRGCYPFWYPEPRGISSAQWQTDVDNRIRFGLRNALKLNIIKTGTTVVAVQGWKGGLGHTNTLRILSVPTDPADLELQPLGSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6P8</accession>
    <name>A0A401G6P8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0107220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608753.1">
        <property type="nucleotide sequence ID" value="XM_027752952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6P8"/>
    <dbReference type="GeneID" id="38774757"/>
    <dbReference type="InParanoid" id="A0A401G6P8"/>
    <dbReference type="OrthoDB" id="3235026at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50040" checksum="CC839C88F1044D32" modified="2019-05-08" version="1">MHPSTSPWGTLPPEMKLSVADLLDPRDMKALAMVDRESYDLCVPSIFRSVKIQSYEALQTYLSTVPSSYSHYIRRLHVCTKLDQSVPHAPVIGRRIVTDTVIDLLAHCSQLEQLTLCLEGSLSKNIIPLFGDLRSLTNLSIHHCGDENRTLLSERFVVSVAAAVPNLRQLSLDRITRSALHAPELIGVYPFIPLVAGDEDIPDHALLGSELRLPSLLRLSGLKKLRIRDTHLGDPQWGSTPVCCSLEVLDLGSCYHESLDFNRICTERIMGNIGHTVDEFALNTALTSQTFEFAKHNEPPLKRLRKVHLTPLFPVENVVDTLTTLSDSPIEQVLVQCHEDDVVDMCSALEDFLSLRVQLGKRGFYQHLTEISVKTVRDITDALTDPFADDAADGSSGIVVGEHTDAVRHLREFLHDLRLTDGNDLSEALRHSLAPASDCSTTSALPLAEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6R2</accession>
    <name>A0A401G6R2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0107430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608774.1">
        <property type="nucleotide sequence ID" value="XM_027752973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6R2"/>
    <dbReference type="GeneID" id="38774778"/>
    <dbReference type="InParanoid" id="A0A401G6R2"/>
    <dbReference type="OrthoDB" id="277961at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23291" checksum="17F55771EDFE7B1A" modified="2019-05-08" version="1">MSQADLQQVPGPSQHAQGPTLSEPSFAVPLASSSVGRVSGKPWKLQKSAAVRSNLPLGVKTKWEVRMEKTKKAHAIKKLQTELREEKMAEVSRRKEITLERKKAAEERRRLEEEKANVRAASLHTLPPVDDTTFRWARGKLPDYAARLAGRKRSTTDTTDIADTVCIGAHEIEHVCQNRGLLFRDVCGDHMHWRPNIQARSTLKLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G791</accession>
    <name>A0A401G791_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-glucan synthesis-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0109180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608949.1">
        <property type="nucleotide sequence ID" value="XM_027753148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G791"/>
    <dbReference type="FunCoup" id="A0A401G791">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G791"/>
    <dbReference type="GeneID" id="38774953"/>
    <dbReference type="InParanoid" id="A0A401G791"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="193"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="611" mass="67140" checksum="D4CA2A8CCAB48FE1" modified="2019-05-08" version="1">MASYGSHSQRRFAQQDSPSTVNLLSPQSSRSSPGVQATLAQPPRSLRSVASDASLNESRYGSNKHSSIPASISDKFSLAPDPSSWGADLSLDHPEIDDDLHNPDPRRDRKHDQGGHIFTARGVVNLGCLAILLTGLVTLFAGYPLISHFTKHRPSKNGGFNIGGMNASGQVPSMPGNFGLVDTDTPKEALYKSDYINNKKWQLVFSDEFNVDGRSFWPGDDPYWEAVDLHYWQTNNMEWLDPTAITTSNGSLKITLSAKENHNLNYTSGMMTTWNKFCFTGGLVEVSAVLPGINNIVGFWPAVWTMGNLGRAGYGASLEGMWPYTYDYCDVGTMPNQTRNSLPLAAMENGDPTNGDILSYLPGQRLSRCSCPGSSHPGPMHEDGTFVGRSAPEIDIFEAQITGDPLSGQVSQSSQWAPFNHQYLWDNTTETYSITNTTATFLNPYLGGAFQQATSGVTENNQQAYELTGAEYAVYGYQYQPGFDGAYIAWIANNQVAWVLQQSGMVADPIVEINQRPVPQEAMYIIVNLGMSKNFGTVDLEHLPFPATMSIDYIRVYQDPSKINVGCDPKDFPTAAYINQYMEAYTNPNLTTWRGDFGQPFPNNSFAAPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7C7</accession>
    <name>A0A401G7C7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0109620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608993.1">
        <property type="nucleotide sequence ID" value="XM_027753192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7C7"/>
    <dbReference type="GeneID" id="38774997"/>
    <dbReference type="InParanoid" id="A0A401G7C7"/>
    <dbReference type="OrthoDB" id="2847449at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="131" mass="14595" checksum="5746E24E10963AEC" modified="2019-05-08" version="1">MAILRERGVLKYVDGTLEKPKPANATTPMAGETAAITKWVEGDQKAQTVIELLLSDSQMIHIADATTAVEMWNQLKLVKEASGQLGIMAYRRKFYRTVATEGSDIAAHITELRRTQEQLHMMGSKVSDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7E0</accession>
    <name>A0A401G7E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Choline</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0109670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608998.1">
        <property type="nucleotide sequence ID" value="XM_027753197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7E0"/>
    <dbReference type="FunCoup" id="A0A401G7E0">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7E0"/>
    <dbReference type="GeneID" id="38775002"/>
    <dbReference type="InParanoid" id="A0A401G7E0"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="460" mass="51987" checksum="D2D50684F58F7971" modified="2019-05-08" version="1">MGPELATTPAVTTPYAQSVLSLRRTSTSSLQSFEDDVSLGTSPVYSASSISIPFEDGDVDVVRVEGLHHANQRLEARRYKSASFAQQLLDILHALRTPSWIHPAIIPENIQIQKVSGSLTNAVFFISCPSVPGTRVLLLRIYGPSSGSLISRPRELHTLHALSSQYHIGPRVYGTFENGRVEEYFESTTLTASDMRDPKISSWIGARMAELHGVDIASVEPTLADESEGDGWELAAKRNVKSWLGLARDVLALPFAPEDVRRHLNLDAFEWEWEQYLRWLAEEEKRIGASPRVFGHNDAQYGNLLRLKTLRPGTLAHRQVIVVDFEYASPNAAAYDIANHFHEWTANYHTEMPHILHPERYPTPDQRRNLYRAYISHFIPPNDIKRPSVLSDEQIEADLDTLDRQVRAWSPASHAVWAIWGVVQARETVEGKDGEPEFDYLGYAQCRMDGFRREIRALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7T5</accession>
    <name>A0A401G7T5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0111230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609153.1">
        <property type="nucleotide sequence ID" value="XM_027753352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7T5"/>
    <dbReference type="STRING" id="139825.A0A401G7T5"/>
    <dbReference type="GeneID" id="38775157"/>
    <dbReference type="InParanoid" id="A0A401G7T5"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000078">
        <property type="entry name" value="Mitochondrial DNA replication protein YHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="169"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="62845" checksum="20A313FD1D45BA55" modified="2019-05-08" version="1">MAANRSQSMFQALQTIWSRGKVSGFYQGLIPWAWIEASTKGAVLLFTASEIESATVGVGVNPAVAGLLGGMGGGIAQAYATMGFCTCMKTAEITRHKQASTGIKPPSTWAVFADIYRREGIRGINKGVNAVAVRQCTNWGSRMGFARLAESWIRQARGKSEKDKLSALEKIFSSTVGGALATWNQPIEVVRVEMQSMTKSPNRPEKVTILSTLKYVYRENGLKGLYRGVTPRIGLGIWQTICMVSFADYVKAWYALLLLLSTGCANALAQDGFMLSAMVYIAILQVCTRPVSPCEPTIPLLPPLSRSGETFYASIQRGHDGSTDIRWIIARGKRDHALLFLKAPTLIYTLSNAPGESTAMSSPVTKMNPLLSAYLRSLATHPVRTKAVTTAVLQFLQEVLASHLAGEPAARVAKDAPFLVHVLARANVDARALKMALYGFCVSAPLGHLLVGASQRAFAGRTGLLAKLGQVLAANLVVAPIQIFVFLTCSAVINGATTVDEVARTVRAGFMRVLRVTWMTLPLTVVVAQRFIPPELWVPFMNTVQFFTGTYFNTKLKKIRMEAEAKAKKDREEKGDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8V9</accession>
    <name>A0A401G8V9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0114990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609523.1">
        <property type="nucleotide sequence ID" value="XM_027753722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8V9"/>
    <dbReference type="FunCoup" id="A0A401G8V9">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8V9"/>
    <dbReference type="GeneID" id="38775527"/>
    <dbReference type="InParanoid" id="A0A401G8V9"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="6">
        <location>
            <begin position="1043"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1223" mass="135002" checksum="9EBDA81AB457CE13" modified="2019-05-08" version="1">MTKTYIMNGLIEKMQSPDQDFRYMGLNDLLLEIKADPNTLLGDESVENKVLRQVLQLVEDKISEVKNQAVKCLGQLIKIIRESQMEFVVDRLIDFSSGKDDELRDISSLALKTITAELPPEGKIAAKACEKLTPKLLVQLSNSNTPPETLIETLSILSILISRFPTYLSNPSLEPQPLAVLTPMLSHPRPAVRKRAITTLAQFLPTSQLQLFSELLSSQIMPGLAPLANVENQRTVVQLVSAVARHSPHQVAPVLDSLVPSIIKAVQRDDEELRESCLQALEALVLRCPSEVTPYLPSIIQAGNQYIKYDPNYAGDEDEDEQMADEDDEDAELDDEYSDDEDTSYKIRRSATKLLAAVVGTRPELLTTLYKEVSPVLISRFGDREVTVRVEIWATYGILLNQTGLYGGLPQSKDGESTIGGKRKRTDDEGMDIEEMPYTLLRSQVPALAKALLSQLKSPKTAPAALQAGFTLLRELLSVLPGCLSSQAAQIIATTKAVLSQSSKTNASTLHVTCMSFIALFFKTHSPPTFAGSLDSITPILLKSLNEKHPRLVSESFRVFSALLGAMQPVKSGEWVDRVYTEATQRLSNHDTDAEVRACAENCIGDLWICATDMVKTKNRREWDAMCRTTGRTDGAVQVITRVAREVEIGDDWVNGCIQWLVILLKKSGRTGKSDMFTCLDALLRRYKVCIPTDLPSVLIPVLKIYITNTDISLLAQALAIVALLLELAPSTTFPEVEQGLLSDIYIIAHSPLVSGAAFESVLAFFAALVEADMQIATHVVPNLVISIEQAPKAEASQSNVARCIGQVVKSQRGVAAGTIAEFTRHLKPASKAKPSQVVLSLLVMGEIGRFIDMSPQHEIFNFAIERFTAEQEEIRTAAAFAAGNMSVGSLHHFLPVIVKIVEHDAEKRLLALHALKEVVTHCSHSQLENVADMLWVPLFENSDNSEETTRNVAAACLGKLTTTHPARYLPQLHERISDENPAARATVLSAIRYTFAESANSYDELLNSLLMDFLSLITDSDLTVRRLALQALNSAARSKPHLIRDHLPTILPNLYKETVINPDLIRTVQMGPWTHKVDDGLEPRKTAYETLYTLLDTCLAKLDLHEFLGHVLTGLLDESDEVKVICHMMLFRLAQVAPTAVAQRLDDITPPLEKSMKGATVTKDTVKQDLERAAELQRSTLRAIVALSKISQQGISPRFDVLVESTRRSSEWGQDFVELVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8Z1</accession>
    <name>A0A401G8Z1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0115230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609547.1">
        <property type="nucleotide sequence ID" value="XM_027753746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8Z1"/>
    <dbReference type="FunCoup" id="A0A401G8Z1">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8Z1"/>
    <dbReference type="GeneID" id="38775551"/>
    <dbReference type="InParanoid" id="A0A401G8Z1"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="282" mass="31745" checksum="016E46148804C8CD" modified="2019-05-08" version="1">MAKRKQQAADADSDSDDDSHRSLVDVDFEFFDPNPDIDYLALKRLLVQLFQADAEYLQINDFADLVLSQPLVGTTVKCDGRESDPYAFLTVLNFHVHQSRPSMRAVIDYALAKSSADPAFHTTLQGLLGPAGLSSQNHVGLIFSERLINMPVEIVPHMYRMLADEIQWAVDDNEPYRFTHLLFVSRIYRLSQEEQEERQGTAPRSKRQKQAPTSAPSTPGLYPFHPEDECIQKFAVHSLDYAFPHAQPREDGLDLGGRMMLVPANRLRDLVAALADSYPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G965</accession>
    <name>A0A401G965_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0116010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609623.1">
        <property type="nucleotide sequence ID" value="XM_027753822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G965"/>
    <dbReference type="GeneID" id="38775627"/>
    <dbReference type="InParanoid" id="A0A401G965"/>
    <dbReference type="OrthoDB" id="2758332at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="144" mass="16609" checksum="F3621CF7018304AF" modified="2019-05-08" version="1">MAHLVFGCRACPSLWTSIHLAWDPPRVRHFFELSADMLVDVYSMLEIDVEDVVQVISSYADCIRGFEYGDEDMENVHEMITSLGFMLPNLQMLDLNSFMSTDEPFRCCFPFSTHSKQQDFPSLYIDYICKSGPTLQFRSELSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9F0</accession>
    <name>A0A401G9F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD-dependent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0116550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609676.1">
        <property type="nucleotide sequence ID" value="XM_027753875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9F0"/>
    <dbReference type="STRING" id="139825.A0A401G9F0"/>
    <dbReference type="GeneID" id="38775680"/>
    <dbReference type="InParanoid" id="A0A401G9F0"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="286" mass="31303" checksum="71E13E3BB413D7ED" modified="2019-05-08" version="1">MATSTDIEAFRGVLKSSKSIVAVVGAGLSAASGIPTFRDFGGLWNSYDPLEFSTPQGFLADPSQVWQFYHQLRELSLHATPNAGHIALAVLCVPENLRIVAPLARFTIITQNIDGLDICALKEVIAKRVQDHHFVAPLSTSQIFEIHGRVVDTLCTVCGHRESRTESPLCQALKNVPFRSETYIPEEDLPHCCQPGCGGLLRPGVVWFDEVPHHLKDVYRVVDEADLCLVIGTSSTVSPAAGFAYEVTEHGGKVAIFNIDSSDDERADFFFAGPCEETLPRIFFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9L6</accession>
    <name>A0A401G9L6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609752.1">
        <property type="nucleotide sequence ID" value="XM_027753951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9L6"/>
    <dbReference type="STRING" id="139825.A0A401G9L6"/>
    <dbReference type="GeneID" id="38775756"/>
    <dbReference type="InParanoid" id="A0A401G9L6"/>
    <dbReference type="OrthoDB" id="2795833at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="431" mass="48618" checksum="12D6E6F028F5FB01" modified="2019-05-08" version="1">MRDEIRRLESRKSWVYVDTLPRSSGHNVVGSKWVFRTKRDARGEVTGYRACLVPQGFTQVKGIDYFSDDTFAAVCKLASMRVILSVAARNGWYAHQVNVKSAYLYGKLRDDEKIYMRPPPDIELDGISPGQLLLLLVVIYRLKQLGQRCQPTSPQGYDPIETGNYRWRNLEKHTVALSQHAYIESIIARYDFADAKPLSQPMDTHAHLSVDQCPVTTAEYAIMRDKPYLEALGALQQLTQFGQNPGIVHWNALKRVYQYLKGTADLWLVLGSSEDNDIVGYSDADGMSTEGRRAVSGYVFMLNGGAVSWSSKRQDLVTLSTTEAEYVALTHTSKEALWLRSFVIELFGDPEHPIPLRSDNQSAIALSKDDHFHARTKHIDIRFHFIRYAIADGKINLSYCPTEDMTADILTKALPSMKSKHFASSMGLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Y1</accession>
    <name>A0A401G9Y1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0201930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609909.1">
        <property type="nucleotide sequence ID" value="XM_027754108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Y1"/>
    <dbReference type="STRING" id="139825.A0A401G9Y1"/>
    <dbReference type="GeneID" id="38775913"/>
    <dbReference type="InParanoid" id="A0A401G9Y1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57644" checksum="677A1308949B7997" modified="2019-05-08" version="1">MWGKVFVAAFFVFLTTRILRFRANLKTVGNLPGLRSAFNPFSLLGAITPTCYLNGGLNWQWLWRRSIYKYYGKQTISCVPILHGEPTVYTISQDVAKQILTASHGFFKSPESTAALMLWGDNVVSSNYDTYRKHRRVVGPAFTGATYAFVAKETVRLYYEMVDGEDWPQKQVVTVDSINQYLSKFALGIVTRCGFGLPFTWVASTEDADGLSFDKALAIVSEGAIMRLATPGWAYKLPIEKLHELDNAYRQLSVFMSSFVANKKEELSSSADPVEGAGSDLFTRLVTASEAEGKDGLVESELIGNIFTFMFAGHETTAHTLAATVAMLALHEKEQEDVYKHIQKVIPSGRDPTFEDYVRLDKVLACFQEAARLFPAGYVVTRDTTETVALRIPPEDGGGTLVLPPGVRVIIDMIGLHYNPSLFPDPEQFDPSRWLGIAESELSFFGLGPRACLGRKFAMTEAVCLLTLLVRDWELGVSLREGESKVQWRERVMQGRMLGLAFGVPNIPVRLRRRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA54</accession>
    <name>A0A401GA54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0202260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609942.1">
        <property type="nucleotide sequence ID" value="XM_027754141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA54"/>
    <dbReference type="GeneID" id="38775946"/>
    <dbReference type="InParanoid" id="A0A401GA54"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="12739" checksum="F0CE3A7D8706D4DB" modified="2019-05-08" version="1">MTELVVDHWWIDIGMEIQGNQQVMWWCSDAPWQILQRVLELDNETVEHYTKTSTFYHDLTAQLTDVGNFRYEPSQSVQQRTKVFYIQAYNMEKSPMYFLNGGNTHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAK2</accession>
    <name>A0A401GAK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0203820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610098.1">
        <property type="nucleotide sequence ID" value="XM_027754297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAK2"/>
    <dbReference type="GeneID" id="38776102"/>
    <dbReference type="InParanoid" id="A0A401GAK2"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40858" checksum="221D43502F7FF88A" modified="2019-05-08" version="1">MDTSPDATDTTAELLSYDDVPYSEQLPAQPTADPSHPQLADRIGNTKVYLLSETSGARVGKRKHGSEEEATNVEDDVSMGDGSPYRENAILFHGTPISHLPTSNIFAYATHFDAHPMALEWIDDTTCILVFPSKPSARLAHRRLAKSIAEEPSTQDGSVTAKPFPVALWPPRDRINKSLGQSEGLKGAIRMRWATTEDVKKRGAKNKSEFYKTYGREGHPGGARESEREEGQPSKRRKSDYKESVERAQLDDDLDAFLAEEDAPSPEPPSPPSKMRSDYIGSDGRTLLERTSMIRAHPDTLASRIMAPLPRRGRSRRGGREQEESDSRSRGERLGEGDRRSRGRRRSQKTEQDLDDELDAFLNEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBM3</accession>
    <name>A0A401GBM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0207470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610460.1">
        <property type="nucleotide sequence ID" value="XM_027754659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBM3"/>
    <dbReference type="STRING" id="139825.A0A401GBM3"/>
    <dbReference type="GeneID" id="38776464"/>
    <dbReference type="InParanoid" id="A0A401GBM3"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="282"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="795"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="313"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="850" mass="96313" checksum="6C1C7528A2167FF8" modified="2019-05-08" version="1">MSRSKSHSIPPQRERSSSWELDADYVNESHIKSFAEALQAEDITPLDHPEPTSPGLSPTVFTPTGPRVRKVSALSDFAPVNLKVKKRKRTGKPQQKRQEWLFLVLRWPLLAIIFLIMAVQFSLYILIRQLVNAKEWLSAWRGRKGILRKRLRSAKTYQEWKDAALVLDEYLHFDEWKTTDEDPYYDWKLVRKVRRSLRNLREKKDARGVLGVLETSIRTNFAGVESARLYSETFYGTKDLIESYITEQEKAIEYVRDTPDLSLEEKKRFFKSANTNLGTSALCLSGGASFGYYHFGVVKAFLDADLLPRVISGTSAGGLVAALVCTRTDTELKHLLVPDLANRITAFEEPFHLWYKRFWTTGARFDSVLWARKACFFTRGSTTFKEAYMRTGRILNISVIPAERHSPTKLLNYITAPDTVIWSALLASAAVPGILNPVVLMEKLKDGTIVPWSWGSKFKDGSLRVDIPVQSLNLYFNVTHPVVSQVNPHVHLFFFAPRGSAGKPVAHRKGKGWRGNFVLSAAEQWLKLELTKNFKLIRDLDLLPELLGQDWSSVFLQRFDGTVTIWPRTIFKDWLRILSDPDPVELDRMLQVGQLVTWPKLHIFENRYRLEKQIILGRQAVRRATRAHGQERSTLRTAELQERDPLPSADTKLFANFTPPVFTPPITLTTSEGPIPIDSDAEAAYLNGSLKDEHYLRTHPPARSQDCRRSSVRRRQWVTNTSHHDERDVLEEGDFGGATPDPPPPTSTASNTPPHPAPQPPLSANSAAGFFKRLRTGSLSSTFSPFASLRRNSRLATSDSHQDSLLDPSYSGDSSSDDELSVISLRRSRVSSLLDIRPDQGLSDEESDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCN9</accession>
    <name>A0A401GCN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0211240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610835.1">
        <property type="nucleotide sequence ID" value="XM_027755034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCN9"/>
    <dbReference type="FunCoup" id="A0A401GCN9">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCN9"/>
    <dbReference type="GeneID" id="38776839"/>
    <dbReference type="InParanoid" id="A0A401GCN9"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="75"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE79922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="21479" checksum="463A4DA0311B577C" modified="2019-05-08" version="1">MALPASLRTSVSPAELELIACEQLVEIIPLVTMDRTVFISGSYGPLRPPSKCKIPIWMATNLKLKKKCHIVPPDWLNVDFLQDRLTRETTEQAFSELPFRFAEVAKVLLDVAPDDFPNTDKIRALLQDIREARQAKSRAGLSKLDHSELSLPNLCSMEINEIRPFFVRAMGVLTQLVREPEARQMHQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD06</accession>
    <name>A0A401GD06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0212710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610981.1">
        <property type="nucleotide sequence ID" value="XM_027755180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD06"/>
    <dbReference type="GeneID" id="38776985"/>
    <dbReference type="InParanoid" id="A0A401GD06"/>
    <dbReference type="OrthoDB" id="2692910at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1104" mass="121595" checksum="203146E95E0C7225" modified="2019-05-08" version="1">MPPRTRSALDASEPRQTRSHTKGVQKVSTASESRPRNSAKKKKDVSPPKDEGHPATDGSKQKSSRTSKTTDVADEEAAESVAQHQGKAKLPAKRDTKARRTSPSDSDGGDGKSVAPASEDDGIDAPSNNDKDTNLDSAEPDAHAAANLHRSVDEADAYNEDESSEEPAGNDGLHEEHGRTDVDRGGDQRVPNTEDSEDGAIYSDTQTIDEPMPGNRDRKLVLRKPTKANQPYVMLPKLRDIRHKQDTTHDAVRKQQPQGQIPDDSMSDGGSDGGFALSSEGDYDMSEYSGSDYSETKKVELMRRENHLRRHQEDVNTEQDDDLLDKEMVDDVVTELEVHGLHARTLEKRNDLRMHSRTVHGKGKQHVVQLDEAEEIAEQEAVAGSANWQKSTGPFSKQARAAAVTFGEVVMREAENLAQKHGKSTRDVLILAGLSFKPSHAANPANKYRQWYSYHHPKADNVTTADYLKEVNTTYKKMFEGVDGQNDEQRALVMKLILDFCDSIEKDPSLAKHSMQSITARMLSAKDQFTALAASYRNLADMEVVGAILYMGTDAGGWQTSAIFGGSSAVKRLIEDNQVDVRKMVDDLTTAIKAVNLNEGGFSLPSSFGRVDVNAQGNEAPRDHFHRVFMAMMQQNLQKFEEAATKCVRWKDWMKTASTYKLCIVDWPPAILALGPDFEFRSLNAAELKVLTDGFIEACQKGRTNIPILHIIRWDQADIDLPDDDPRKGKGLVTLVKDTKGNRLRVLRDIAGWARIVAHAAPKGRCRHVSPVALPSSSESEELPTPNVRPVRGLPPRARSVVPARTINTDIAPPRKHRREASSDGSDIEEISPTRKTLGHKPQSIQGYEGPGQASRPPSRNHHPRYNEPSTRGRDAQCVSRHSRDHDGGAAHSNNLHIMARARMGEASNYLAPPGQVFPLPQDEQFGGGAQYPHQVPPHNSLVGPARPRIPSAASSHNDHVPYSYADQYSSRLPQQHLRSIQGLLPPPHWPRAPTSQLHASHRSQDFDAAGNGQCRRDDQSTRASGSRPSAGTSGALHGAQADTSRAHRVATSLHESEPGPSRRVEVAHPCQRVVSPIYDEGGYDDYGDLFDGDDKGNDWYHEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD14</accession>
    <name>A0A401GD14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aspergillopepsin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0212540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610965.1">
        <property type="nucleotide sequence ID" value="XM_027755164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD14"/>
    <dbReference type="STRING" id="139825.A0A401GD14"/>
    <dbReference type="GeneID" id="38776969"/>
    <dbReference type="InParanoid" id="A0A401GD14"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="102"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="417" mass="44839" checksum="089B6FD0F1D303E4" modified="2019-05-08" version="1">MGCFPSKSSSEPPQASTMPQSKLQRLERPSRYPKGQGPSFYAAYARAARRYGFEAGVYAGFAKRNNVVVKVRGKEDKSTEHEVPAESIQNGEIRRFSHITEYVVQVTIGTPGVTLNLDFDTGSSDLWVWSSELAGVSTSGHNIYNPKNSSTAVKADGTWNISYGDGSSASGDVYADNVIVAGITISKQAVELASKLSSSFLQDGGNDGLLGLAWPAINTVQPQSVATPVENMISQKLINPSVFTVKLGHGTEEESFYSFGYIDKTVTSSPITYAKVDNSQGFWQAESTSWTLNGEKKTRSGNSAILDTGTTLCLVDDSVLEAIYGAIEGAQYSNQQGGWIFPTNAKIPEVSFAVGETLYKINAVDFAFGDAGDGNTFGGIQSRGDLNFDIFGDIFLKSVYVVFDQGGQRVGLAQRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDU0</accession>
    <name>A0A401GDU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0300730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611271.1">
        <property type="nucleotide sequence ID" value="XM_027755470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDU0"/>
    <dbReference type="GeneID" id="38777275"/>
    <dbReference type="InParanoid" id="A0A401GDU0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="179" mass="19449" checksum="80A1775DF7477BB5" modified="2019-05-08" version="1">MPPQPVGAAEAASSTGKCALRSATPATPTIPTNPKPDLIIPMTVKVKMIDDAVKVLQKHKLVDEGSPELQSLVTGLGKLAQIATKASVMVDIITAFAHYASMLTVEEAASRIVEQVVHRTYQAFDRLEETATQLDQIETQYKVHADTTGHLLKKLAEEHKKLGERTVQLEEAAKKMLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE44</accession>
    <name>A0A401GE44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611362.1">
        <property type="nucleotide sequence ID" value="XM_027755561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE44"/>
    <dbReference type="GeneID" id="38777366"/>
    <dbReference type="InParanoid" id="A0A401GE44"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8625" checksum="0166EC2CD7C80D70" modified="2019-05-08" version="1">MDPALRGDALRMQASSSSPSKSPALTTPPPTLAYCGTLQHRRQHQPATLVPPSTSAQQPHDGGTPPEARERAHFPHFIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEM4</accession>
    <name>A0A401GEM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0303610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611557.1">
        <property type="nucleotide sequence ID" value="XM_027755756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEM4"/>
    <dbReference type="GeneID" id="38777561"/>
    <dbReference type="InParanoid" id="A0A401GEM4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="12096" checksum="4DB5006DA2688E63" modified="2019-05-08" version="1">MAETNSTENAKKQKTVMLVAQVSDHQMRIEVLEGEKELLRMEMESFKTVAETYEKRLETAIDRLDKQARLIGGLQDLASELQAQNSYLGRPSPFEIFSYLMLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEQ6</accession>
    <name>A0A401GEQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611496.1">
        <property type="nucleotide sequence ID" value="XM_027755695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEQ6"/>
    <dbReference type="GeneID" id="38777500"/>
    <dbReference type="InParanoid" id="A0A401GEQ6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7668" checksum="E6E8544EEBB3D905" modified="2019-05-08" version="1">MRIAQAMLRDDIVCGLGTTFGGRRSGSEDRRATRPETGDRRDRPHISGKNQRRERFGGASHSRKEDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GER8</accession>
    <name>A0A401GER8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0303880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611582.1">
        <property type="nucleotide sequence ID" value="XM_027755781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GER8"/>
    <dbReference type="FunCoup" id="A0A401GER8">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GER8"/>
    <dbReference type="GeneID" id="38777586"/>
    <dbReference type="InParanoid" id="A0A401GER8"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="324"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="564"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="135"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE80669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="657" mass="72981" checksum="214B0796F4D844E3" modified="2019-05-08" version="1">MKALYPASHEIPQLSDALLALKISRHSSCTACPSCYGLRPPPDVQVVLDTEHLASSLGTLAIYGSDDDDGSTSYLEICACGHGVADHGADIASIGKEEFDRRGRVAVRLDELLQDCSKLLDFEFTNEDIQSLRQQMQLPPDSPHSSLSDVLGSLVPSPGQPLSPASSFLSDNFEPPSKKRRVSFSSLSDADDDDDDEEEDKPLAASVSAAPPAPTRENGTRGVAHRSGKQMPSMKSKAHTAPATIAPPTGEEQTAMNRPAESVIGREPRIKVEDKMDEGQLTRLATGVTVDASGTTTTMPSLKPEKMAHIELRKGVIRVVAVENDAQPRSWVILTGLKTLFQKQLPKMPREYIARLVYDSNSRCLAIVKHGFKVVGGICFRPFPHRGFAEIVFFATTSIDQVKGYGGMLMDHFKSHIRNTYPDMMHFLTYADNYAVGYFRKQGFTKEITLDRSVWAGYIKDYEGGTIMQCTMLRKVNYLETRDIISQQREAILTKIREMSRSHIVYEGLPQFREGAPEGITVDPKDVPGLRESGWTPSMAALPPRPSGRSVDHSAMQKLLSDLQGHPLAWAFLQPVNGQDVPDYYDVIKKPMDFSMMEHKLDTNQYPNLDAFLVDAQLVFENCRSYNPEGGTYYKNATKVEKFVKEQLSLYQLKHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEV1</accession>
    <name>A0A401GEV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione-S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0304430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611637.1">
        <property type="nucleotide sequence ID" value="XM_027755836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEV1"/>
    <dbReference type="STRING" id="139825.A0A401GEV1"/>
    <dbReference type="GeneID" id="38777641"/>
    <dbReference type="InParanoid" id="A0A401GEV1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="112"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="256" mass="29754" checksum="3B621961662F38B8" modified="2019-05-08" version="1">MSIPDEKIFPHATGLAAKTVELHQQPQDLVFYAGWFCPFVQRSWIALEEKGIPYQYKEVNPYKKEKRFLEINPKGLVPAVEYKGKALYESLIICEFFEDAYPSYTPHLLPSDPFERAFVRLWVDFISKSIVPAFHRVIQAQDAEKQKAGLEEFNRALRTLAEKVKGPYFLGEQFSLIDVALAPWVVRDYIVQEHRGYTREAVGARWKEYAESLEKRESVLKTQSDKEHYEEIYARYLRDEAQSEVAKAIRSGRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFJ8</accession>
    <name>A0A401GFJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SCP_0306610</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611852.1">
        <property type="nucleotide sequence ID" value="XM_027756051.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GFJ8">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFJ8"/>
    <dbReference type="GeneID" id="38777856"/>
    <dbReference type="InParanoid" id="A0A401GFJ8"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000064">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1072"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1108"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1137"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="157"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="247"/>
            <end position="316"/>
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        <location>
            <begin position="958"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="534"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <position position="535"/>
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            <position position="734"/>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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    <sequence length="1284" mass="144366" checksum="A867F9DF941FEF6F" modified="2019-05-08" version="1">MSDDFVRLVSQANPASRQYQPANNGYPPSTSASHHPHSEQALDPFFDDEDEDDFLDSAFGRPAAMQSKESGFPLTQAAAPPAGSGNSQLSLPAAIQSDWSFDDEPTPLPISSVPFHGSASTTSQKHRKRPSQSFRKRWKWPWQKKEQVLTGERVVVLNSHLANAEFCSNYVSTTKYNALTFVPKFLYEQFSKYANLFFLFTALIQQIPGVSPTGRYTTIVPLAVVLLASAFKETQEDLKRHQSDSELNARKSKVLTPEGTFAEKKWKDIEVGDVLRLENDDFIPADVILLSSSEPEGFCYIETSNLDGETNLKIKQASPQTSYLISPHLVTVLHGSLHSEHPNNHLYTYEGTIELTTNDGLPKQVPLGPDQLLLRGAQLRNTTWAYGLVVFTGHETKLMRNATAAPIKRTAVERQVNVHIVFLFVLLLALSLGSTIGSSIRTWFFSSQQWYLYETSSIAGRAKNFIEDILTFIILYNNLIPISLIVTMEVVKFWQAQLINSDLDMYYARTDTPALCRTSSLVEELGQIEYIFSDKTGTLTCNEMEFRCCSIAGIAYADVVDESKRGDSEDGKDGWRTFAQMKTLLSASENPFTDVPSEANAERETVHEFLTLLAVCHTVIPEVRDGKMHYQASSPDEAALVAGAELLGYQFHTRKPKSVFVNISGAAQEYQILNICEFNSTRKRMSTIVRCADGKIKLFCKGADTVILERLGEKQPYTEKTLLHLEDYATEGLRTLCIAFRDVSEAEYQQWSTIYDQAAATINGRGEALDGAAELIEKDMFLLGATAIEDKLQDGVPDTIHTLQMAGIKVWVLTGDRQETAINIGMSCRLISESMNLVIVNEETMPDTRDFLTKRLSAINNQRNTGELEDLALVIDGKSLGFALEKEISSTFLELAIMCKAVICCRVSPLQKALVVKLVKKNQKAILLAIGDGANDVSMIQAAHVGVGISGVEGLQAARSADVSISQFRFLKKLLLVHGSWSYQRLSKLLLFSFYKNIVLYMTQFWFSFFNNFSGQVAYESWTLSMYNVVFTVLPPLVIGVFDQFVSARILDRYPQLYMLGQKNAFFTKTAFWLWVANALYHSIILFGFSIILFWGDLKQATGYDSGLWFWGTMLYLSVLLTVLGKAALVSDLWTKYTVAAIPGSFAFTMVFLPLYAVVAPAIGFSTEYRGLVPRLWSDAVFYFMLILVPIFCLTRDFAWKYYRRTYHPETYHIAQEIQKYNIPDYRPRQEQFQKAIKKVRAVQRMRRNRGFAFSQTENAARQDQARMIRAYDTSKAGARPTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGE9</accession>
    <name>A0A401GGE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0309320</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612118.1">
        <property type="nucleotide sequence ID" value="XM_027756317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGE9"/>
    <dbReference type="FunCoup" id="A0A401GGE9">
        <property type="interactions" value="692"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGE9"/>
    <dbReference type="GeneID" id="38778122"/>
    <dbReference type="InParanoid" id="A0A401GGE9"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="14">
        <location>
            <begin position="244"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="15">
        <location>
            <begin position="479"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="730"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="779"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE81205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="842" mass="92287" checksum="33644E6677F47995" modified="2019-05-08" version="1">MADVPTLRITLLGAGQEVGRSCCVIQYRGRTIVCDAGVHPAYSGIASLPFVDELDWSTVDVLLITHFHLDHAAALTYITEKTNFRDGKGKVYMTHPTKALHKFMMQDFVRMSSSTSDALFSPLDLSMSLSSIIPVSAHQVITPCPGVTFTPYHAGHVLGACMFLIDIAGLKILYTGDYSREEDRHLVKAEVPPIRPDVLIVESTYGVQTLEGREEKELRFTNLVHSIIRRGGHVLLPTFALGRAQELLLILDEYWKKHPDLQNVPVYYASSLARKSMAVYQTYIHTMNANVRSRFAKRDNPFVFKHISNVPQTRGWERKIAEGPPCVVLASPGFMTVGPSRELLELWAPDSRNGVIITGYSIEGTLARDIQSEPEEIISLKGATIPRKLSVDEVSFSAHVDYSQNSEFIEMVKAQHIVLVHGEQTAMGRLRAAMQNRYKSRDEDVKIHTPRNLETLELTFRGERVAKAIGALAAKPPQANDILSGLLVSKDYSYTLLDPRDLRDFAGLTTCVVTQRQRMVLGVGWDLVRWHLEGMFGKVEEGFDKDGVPTIRVMGAVDVKQTQEHELLLEWDSSASNDMIADATLALITGIDQSPASVKLTTHPHTHAHAPEHPHPHADVEDDGAAVTRIQRLAMFLEAHFGEVELHMPEETDEPEQGEDSHEPSLLVRLDEADAIINLVSMTVTSANDALRKRVESVLDMAVSTIASLSEAFTSGVPLLSEEAAAAEAVKQTHSASPAVPGSDRQSEPIFESGPAAAAPLEESRPVAIATEVQEHAAEALRKAENAEGTGTPEGVSAQAEGHPGNQDGEQHLQDGDRPGHEGGDEESDSGSDDDAILQVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGL5</accession>
    <name>A0A401GGL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S18-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0309700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612156.1">
        <property type="nucleotide sequence ID" value="XM_027756355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGL5"/>
    <dbReference type="FunCoup" id="A0A401GGL5">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGL5"/>
    <dbReference type="GeneID" id="38778160"/>
    <dbReference type="InParanoid" id="A0A401GGL5"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="156" mass="18005" checksum="BE1367FB31AD5E3C" modified="2019-05-08" version="1">MSLVLPEAHQQFQHILRLLNTNVDGKRKIMYALTEIKGVGRRYANLVCKKADVNLDKRAGELNSDELERIVTIIQNPTQFKIPTWFLNRQRDIVDGKNSQILSNAVDSKLRDDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGKTVGVSKKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGM7</accession>
    <name>A0A401GGM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0310120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612198.1">
        <property type="nucleotide sequence ID" value="XM_027756397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGM7"/>
    <dbReference type="STRING" id="139825.A0A401GGM7"/>
    <dbReference type="GeneID" id="38778202"/>
    <dbReference type="InParanoid" id="A0A401GGM7"/>
    <dbReference type="OrthoDB" id="2802867at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE81285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15066" checksum="7C326B03AFE5A6EE" modified="2019-05-08" version="1">MMAPVGYLLYASLLLAVVVYVRTRRRSLPFPPGPPAESVIGHLRVLPPVDQVDVFQEWAAKYGDIFYLNVLGQSIVVLNKYQAAADLLDKRSANFSDRAKCVSYDLMGWKRSSAVLPCDPTWRKHRKMYQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHM9</accession>
    <name>A0A401GHM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0400290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612571.1">
        <property type="nucleotide sequence ID" value="XM_027756770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHM9"/>
    <dbReference type="STRING" id="139825.A0A401GHM9"/>
    <dbReference type="GeneID" id="38778575"/>
    <dbReference type="InParanoid" id="A0A401GHM9"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005732">
        <property type="entry name" value="PRK07550.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="90"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="423" mass="46005" checksum="640162D38BB7D424" modified="2019-05-08" version="1">MRSPKAEWASNTGVAFRLSHGIEITTRPPIPQAYEWAAAYVPTADRPLLDMSQGVPGVSPPKLLLDALGATSSSPMSCGYVGNVGELSLRLAVVEDIKQKYGADADVTPDDLAITAGCNLAFVSVAIALADAGDEMILPVPWYFNHEMSLTMLGIKPVSLETSPEDGFMPSPERCAALITPKTKAIVLVSPNNPTGAVYPPSLIRAFADVAAAHNVALIIDETYRDFILSGAPHDLFLPRPSRPSWRSTFIHLYSFSKAYAIPGHRLGMICAAPALITAVSIALDTIQICAPRPPQLALAPLLPTLRPFVQETARAVAHRHTLFKAALPQHWKIGSQGGYYAFVRHPFRGRRATEVCQRLAKERGVVCLPAGIFAPKIEDCSAGEDEERWIRFSVANVNDQKVKLVCERLEESEVMFGWELDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ36</accession>
    <name>A0A401GJ36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0405620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613095.1">
        <property type="nucleotide sequence ID" value="XM_027757294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ36"/>
    <dbReference type="GeneID" id="38779099"/>
    <dbReference type="InParanoid" id="A0A401GJ36"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="15017" checksum="F59BF7A6B2936B5F" modified="2019-05-08" version="1">MDEVKWDIAAAMLVAGENKSDYAGGEGLYLVPAGSPGEGFPTQTLNDAPSSAAAQTYSLPHKTTIHFTLGAYHRWACGGITPLALAAVVLIVTPLRTVTQILTPIVTYDTPYTGEHYNKFIVMAHTAAVPYTPEPAVVAVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ59</accession>
    <name>A0A401GJ59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0405310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613064.1">
        <property type="nucleotide sequence ID" value="XM_027757263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ59"/>
    <dbReference type="FunCoup" id="A0A401GJ59">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ59"/>
    <dbReference type="GeneID" id="38779068"/>
    <dbReference type="InParanoid" id="A0A401GJ59"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="916"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="663"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="835"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="835"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="866"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="945"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE82151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1189" mass="129031" checksum="9833B97F35BE0895" modified="2019-05-08" version="1">MTAVIAASTALQVLDDPSQPTSQTPSPTSPTPSLQNVYRSTGNPNGIASSAYASSSLYQNVTLDLPPGMSYPDFLRTWTDARVARWLTDIKCGHHAATFKANDIRGDVLLELDQVTLKEMGMTSVGDRLRIVNAVKFLRQRCSSTSSPLSVFVNRPRFSVPEHSRSPSGDLHNSAARGVNRRLEGSRPAPLHLTPAGSLDLPRVVRDGQDSAKYIPSIRPLPQPSSGSSHGTPTTAHSTRSNLPPLPPPPRGQPPLPPTNGRLTPRSLQAPANPLSGRRTPESSPLSSHPAPHGQNLLSPASQSSGSSRLGFNLSPDTRQGNRTPIRTTSPLPLPPISSNSRNLVRPPNESGSHNRNTSLSNPASNPPGKSPSRPPQGNSPHPYASSNPQHGLSPIAESFATQRSGSNAPSYKAGMSPLLRPGTPSYNTPSLDDLKRKLAKFILPDEGQSTRINTADCTDGVEVLMRALKKLGKLSSRLSPDSVEHVELEHGALCVDGWGAYLDYGQDGTTNGPLTAAQLLSICQAPADDPARDYGLTLRVIERLPRRGESPTSLVFANPDFDPDEELMAPDIPGAHTPSTKNMKRASSVSILSGLGVRIPEKASDTSASNSPSQSPVKSASGGKKVPSKLRNFFGQRPPSELITTHLAEYFPFTEKKVLERTRRQSMMRTSGARAPDRRDSIISWNPPPSRFSVSTLGSQQNASPRVSVSSASVPLPDKPPPPVPTVERLGPPLRLSLSTDEGHSLEITETDQSEASKRVSSPHILPPVAFPSESLSESLNLGPSLQGTVTFPRTLSNASKRMSYITELRSKRDRSDAASLLTVDEITAEVENREISESKKDVESSEEWTKVDVEDEYDKQSIKEEDEEDDDVAGEEEESELDEDDADDVTVEVDDEGEPGKAITSRGSERTIKWIKGALIGAGSFGKVYLGMDAATGLLMAVKQVELPTGSAPNEERKKSMLSALEHEIELLKEFHHENIVQYHSSCIDDDHLNIFLEYVPGGSVTSLLRNYGAFEEPLVRNWVRQILLGLNYLHERDIIHRDIKGANMLVDNKGGVKISDFGISKKVEDNLLPGHRAHRPSLQGSVFWMAPEVVKQTAYTQKADIWSVGCLVVEMLTGEHPWAQLTQMQAIFKIGSSAKPTIPADISAEAENFLQLTFELNHKARPTAAELLKHPWIVNQPLPLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJC5</accession>
    <name>A0A401GJC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0406480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613177.1">
        <property type="nucleotide sequence ID" value="XM_027757376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJC5"/>
    <dbReference type="STRING" id="139825.A0A401GJC5"/>
    <dbReference type="GeneID" id="38779181"/>
    <dbReference type="InParanoid" id="A0A401GJC5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="37958" checksum="B12F96DD3EE4A384" modified="2019-05-08" version="1">MDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDVGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDPNAMDVDCVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETLKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKY6</accession>
    <name>A0A401GKY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0412200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613746.1">
        <property type="nucleotide sequence ID" value="XM_027757945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKY6"/>
    <dbReference type="GeneID" id="38779750"/>
    <dbReference type="InParanoid" id="A0A401GKY6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="197" mass="22868" checksum="432DAD90F234CBDC" modified="2019-05-08" version="1">MTGYYWLDGQEHSLCPARHTYLATPLRTSEVNNLTHWLTIADWLVERHLHLATLHERYACEDGLTTIKRAHRRLDALAERLGAAVTRATFDVAWTHHHVTRDCIKRDVATPTTVPALPASPSLVSEKLAKPEHPRHIKNDAPHLDRKNRPQKPVGESVGVKEAEERRREERRPEKKVQERTRRDQEQERMPCKHDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLY4</accession>
    <name>A0A401GLY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0502700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614136.1">
        <property type="nucleotide sequence ID" value="XM_027758335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLY4"/>
    <dbReference type="STRING" id="139825.A0A401GLY4"/>
    <dbReference type="GeneID" id="38780140"/>
    <dbReference type="InParanoid" id="A0A401GLY4"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="6">
        <location>
            <begin position="42"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="293" mass="33134" checksum="F988783DD97318CF" modified="2019-05-08" version="1">MIEVAGHTQETDQRLIARINPEIWPTQEEIHSAMKRIDYQDGVFHCAVAGIAGSGKSSLINAIRGLSNSKSKHPDAAEVGSTETTRHVTRYPDPNPKKPVVWYDIPGAGTLTVPSPQYFNAQGLFLFDCIIVLFDNRFTETDVSLLHNCSRFNIPSYIVRSKSNQGIKNTVEEMREDDEECEDSLLYERARERFTARAKESVRENLSRAGLLDQRVYIVCRDGLRKVVKPEENSQVNIKVVIDEEVLLQDLLKEAYDRRVEDAAVAKSALAERIKQLWARCQLAAPQWVPHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLZ0</accession>
    <name>A0A401GLZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0502060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614072.1">
        <property type="nucleotide sequence ID" value="XM_027758271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLZ0"/>
    <dbReference type="GeneID" id="38780076"/>
    <dbReference type="InParanoid" id="A0A401GLZ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="15902" checksum="5373EE93FE56953E" modified="2019-05-08" version="1">MGTKTSDTSSDTPLMEYPHPLLTRHQNQFPFDLALLVRTYPVDDLHYPNHLSRLHPLPRIAVTPTGMDVSPNKDHEPAGGHATDVEEIIMFATAPDDDEDHNISCGTRNVRRELMLQRSPLVARLFFFFSLFPLRYQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM31</accession>
    <name>A0A401GM31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="5" type="ORF">SCP_0502560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM31"/>
    <dbReference type="FunCoup" id="A0A401GM31">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GM31"/>
    <dbReference type="InParanoid" id="A0A401GM31"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="305" mass="33847" checksum="157AC8518A2A9246" modified="2019-05-08" version="1">MHCCKHTVLRRVCPSPAPRLFRFNHSEASGNNAQNLQTPPRTTHFGFRTVPEETKESLVKNVFDSVASSYDLMNDAMSLGVHRLWKDDFVSQLKPGSTGPTKCIDLAGGTGDIALRILDFARERYADRETSVDVVDINGEMLKEGHKRFKKTMYHNTPQIAFIEANAQELPESQFPSNAYDLYTIAFGIRNCTSVPDVLKEAYRVLKPGGTFACLEFSKVNNPLFNAVYDQYSFSIIPLLGTILAGDRESYQYLVESIRKFPSQPDFVAMIADAGFATGGNHEGKGGAWRDLWGGIAAIHTGVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM62</accession>
    <name>A0A401GM62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0503330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614198.1">
        <property type="nucleotide sequence ID" value="XM_027758397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM62"/>
    <dbReference type="GeneID" id="38780202"/>
    <dbReference type="InParanoid" id="A0A401GM62"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="197" mass="21017" checksum="819B9CFB73DD3DB6" modified="2019-05-08" version="1">MAPNRLIEDLSARHNLPAMASDAEPPDTLDIMMGESDEEDSIAEPRRPLISDLLDSPGSAQISLPLHSASQTPLAPRRTTPSLAAPFAPSNSPHEHLHHHASPKVQASSGSVAPVEGSRALIPDPLAPAWDESRGSSPIHRRALISDSTPTAPGGMFDFDTPGISPIPRRTLLEATPLPPPAHTFDFRTPDTSQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM89</accession>
    <name>A0A401GM89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0503170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614182.1">
        <property type="nucleotide sequence ID" value="XM_027758381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM89"/>
    <dbReference type="GeneID" id="38780186"/>
    <dbReference type="InParanoid" id="A0A401GM89"/>
    <dbReference type="OrthoDB" id="2688889at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="214" mass="21720" checksum="201C78B11949C0A2" modified="2019-05-08" version="1">MFISLQSPPVAQGFSAQTPGHDWASIQLALEYTLAWVTAVENEDFCQCNYPRPGDPEVLDDLGMCIGDMCLDEPVGDNGEFVGEMDFKQQDLSPGADTALVDDPAAPAIAAAPAIIPAPVTAAAPAALAVVGPVVTGPGPIAQAPAGPAAGAPAIAAIAAVPPAGPGGFEIPPSFAAALGIELPRPAQPNDHAPFYCVTHGCVVGVFNDWDVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMA1</accession>
    <name>A0A401GMA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0503600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614225.1">
        <property type="nucleotide sequence ID" value="XM_027758424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMA1"/>
    <dbReference type="STRING" id="139825.A0A401GMA1"/>
    <dbReference type="GeneID" id="38780229"/>
    <dbReference type="InParanoid" id="A0A401GMA1"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF2">
        <property type="entry name" value="DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="263"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="46159" checksum="3107C22CEB1965DE" modified="2019-05-08" version="1">MSIPPSGTQRAVRWYPPAYDIRVETVPIPQILEPDDAIVMIKLAGLCGSDLHIYRGHEDVDADLTCGHELIGEVVALGASFHPGATDRPELYSTLRVGDKVVSPFTVSCGECHFCRIGFTCRCIHSTLFGIPKLPGGQAQYTRIPKAGGTLFSLSALAAQGKVDATSVSDSSLLLLADILPTGIFAALQALQHPKILPVLTGRAYPTSGFIPDSAISGQGATTLQRADRVLTIAVVGLGPVGVCATVSLLDMLATIGVQQGLEYNVVAIDPNESRRRKVEAVYAAIDTTSKGSGSFTVASIDEGKQMVQKNSNGAGANAVLEVVGNNSALKLAYELVRPFGLISSVGVHQEPPIPFTGREVYDKNVSFDFGRCPVRAMFPLALEILLKRQDVFGAVGEEASLVEKIVGFDEAKESYELFDKGECGKVLFNPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMU6</accession>
    <name>A0A401GMU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger C3HC4 RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0506160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614474.1">
        <property type="nucleotide sequence ID" value="XM_027758673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMU6"/>
    <dbReference type="STRING" id="139825.A0A401GMU6"/>
    <dbReference type="GeneID" id="38780478"/>
    <dbReference type="InParanoid" id="A0A401GMU6"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C3HC4 RING-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="373" mass="40518" checksum="069F21CC78125BC5" modified="2019-05-08" version="1">MYKPYALAPCGHTACHSCLVAWFKAPPPDARPQDVLPTWLRKKTCPHCRAVVKERPIGVWTVKDMVAALVKSGLAAAAFPPSPAPDAEVPTADPWEGIFRREPGASGNHRQVFPGPPPALFQQMLGLHDVEDGGIYRCIDCNHEIWDGVCSSCGRVYPGHGGGDDEDDYPEDYELEEAELAGLMFGGPYNILNHLHGDGSGDEGDSDGSLGAVNFGDGNTELNGSDDEDSEEDYESSFIDDDEHVVRDRLHSPRDHASEGSGGPLIRHRVGGGSSGNRPRPRARREVPRSSPIVISDGSDDVESISSVQDLPRLGRRARLVDSASDDETSIADAERDLSAVVAAREFDVYGDDGSVPRWRALRDIEDDEHNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMZ6</accession>
    <name>A0A401GMZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0506410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614499.1">
        <property type="nucleotide sequence ID" value="XM_027758698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMZ6"/>
    <dbReference type="STRING" id="139825.A0A401GMZ6"/>
    <dbReference type="GeneID" id="38780503"/>
    <dbReference type="InParanoid" id="A0A401GMZ6"/>
    <dbReference type="OrthoDB" id="3250555at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25106" checksum="6128304EA1D5BE15" modified="2019-05-08" version="1">MRYFLRVGSGPESPKARGMDMILLREGREAVTWDVAVACIALCVKFHRDSLLPLYIILACEFLSIAPHSISNDDLEASQRDVLQTFSFNIGSITPESYMQELWLALPSLRKLLGFDNGWKVAQTEAWSVLLDALLQEDMLRFPVSLLTASALIDGVIESLARRYMEESFRKVGWLTTSCQCRQFRKKAIKAASGFMLDIQEILGYSAKDLKFCRQWLRSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN02</accession>
    <name>A0A401GN02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0506530</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614511.1">
        <property type="nucleotide sequence ID" value="XM_027758710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN02"/>
    <dbReference type="FunCoup" id="A0A401GN02">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GN02"/>
    <dbReference type="GeneID" id="38780515"/>
    <dbReference type="InParanoid" id="A0A401GN02"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="90"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="357"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE83598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="741" mass="84436" checksum="9169CC9383291541" modified="2019-05-08" version="1">MASAVLQSDHPSSAPHPVSSSSHPVQLSALKGPHANGDQKPHKEKKDNTASASAYPLELNPPPEFFHHKIQIFDKLKAEYDEWVKVQPRQEIQITLPDGSVRQGRSWETSPMDVAKEISRGLADRIVIAKVNGDVWDLERPLEGSCKLELLDFEHPEGKRVFWHSSAHVLGEAAERHYGCHLCIGPPTEEGFFYEMALDDRVVTNADYPALEKVSDLAIKQKQKFERLVVPKETLLEMFSYNKYKKYLIESKIPDGTSTTVYRCGPMVDLCVGPHIPHTGKIKAFMVTKNSASYFLGDPKNDSLQRIYGISFPDKKQLVEYKEFLAEAARRDHRKIGKEQELFFFNDLSPGSCFWLPHGTRIYNTLTELLRSEYFKRGYQEVISPNMYHSKLWETSGHWQNYRDDMFTLIVEKEPWALKPMNCPGHCLIFDSRDRSYKELPIRMAEFGIVHRNEASGALTGLTRVRRFVQDDTHVFCMPSQIEEEIGALFDFMEHVYGLFGFDFKLELSTRPDNYLGAIEAWDEAENQLKKALDKQYPGKWELNPGDGAFYGPKIDITIRDALRRSFQCATIQLDFQLPERFDLKYRSADNSANADKGPSRPVIIHRAILGSLERFIAITTEHFAGKWPFWLSPRQVLVVPVAAPFKDYASEVANTLSDLGIFADVDNGENTLPKKIRNGEISQCNFILVVGQQEYDNRSVNVRNRDDVGTKAKGEMVPLDEVVKKLVALKASRCLENKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNY3</accession>
    <name>A0A401GNY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine adenosyltransferase 2 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614772.1">
        <property type="nucleotide sequence ID" value="XM_027758971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNY3"/>
    <dbReference type="STRING" id="139825.A0A401GNY3"/>
    <dbReference type="GeneID" id="38780776"/>
    <dbReference type="InParanoid" id="A0A401GNY3"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="301" mass="33303" checksum="3BFCEC86EBB0AA57" modified="2019-05-08" version="1">MRVIVTGASGVLGAAVYAAFKSAENTVLGLAHSRPGEEFRQLDLLDAPSVERVFAEFKPDWVIHCAAERRPDVAEKDPEGARKLNASVPEHLAQLSKTQKFGLVYISTDYVFDGTSPPYTPSAQTNPVNLYGQTKRDGELAVLGVLGSRSIVLRVPVLYGPAPKNTDSAINILLDVVADQSGKQYKMDHYATRYPTCVVDIADFLVRLTSIPPNRAIPPILHYSAGEPFTKYEICLVFARILGVPHVHIIADAEAPKDAVTTRPRDCQLYTRETEDLMEGYGGLGWTPFEEWWVQYLNEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP35</accession>
    <name>A0A401GP35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0510420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614896.1">
        <property type="nucleotide sequence ID" value="XM_027759095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP35"/>
    <dbReference type="FunCoup" id="A0A401GP35">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GP35"/>
    <dbReference type="GeneID" id="38780900"/>
    <dbReference type="InParanoid" id="A0A401GP35"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="360" mass="38095" checksum="E5C3D9009181A02B" modified="2019-05-08" version="1">MSSPNFVIPKTQHAAIVESTGAPLKIKSDHPVKQPADLLPGECLVRLDCSGVCHTDLHAAKGDWPIKAKLPLIGGHEGVGIVVAIGAHTQGSPVKLGERVGIKWLAYSCLDCEMCRKGLEQSCLNGQYSGFSVDGTFSQYVVSWVSHVTPIPENLPSTEAASILCAGVTVYRALKNSNTHIGDWVVLPGAGGGLGHLAVQYASAMGLRVVAIDTGAEKRDLCLKLGAEVFIDFRETKDLVKDIKAATDGLGPHAAVVTAATSQAYKQAIDYLRMGGTLVVVGLPAKASLDADIFFTVTKSINIVGSYVGNRQDAREALDIASRGKVKCFYVVKPLSALAETYEGLEQGTVVGRVVLNMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPT4</accession>
    <name>A0A401GPT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0601900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615125.1">
        <property type="nucleotide sequence ID" value="XM_027759324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPT4"/>
    <dbReference type="GeneID" id="38781129"/>
    <dbReference type="InParanoid" id="A0A401GPT4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="12707" checksum="DD0CF8846BFE9083" modified="2019-05-08" version="1">MPTRKLIPKPYEEQSLTLCRSDIYGFSAGPPGEPQNTPAKLSRTREQLPWPVLHAQLILKMTLERRLVNQPLIDRKKESFLSIDLERQINKLQTHPLEDHRSAVLGNEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPX7</accession>
    <name>A0A401GPX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-dependent 3-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0602300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615165.1">
        <property type="nucleotide sequence ID" value="XM_027759364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPX7"/>
    <dbReference type="STRING" id="139825.A0A401GPX7"/>
    <dbReference type="GeneID" id="38781169"/>
    <dbReference type="InParanoid" id="A0A401GPX7"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019127297" evidence="5">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="300" mass="33200" checksum="7611E4847F9D39B6" modified="2019-05-08" version="1">MSSKVWLITGTSSGIGLALAQHVLAQGDKVIATVRSMSKYPQELKGAEPLVLDLGAPDSEIRKVGEAALKVYGHVDVLVNNAGYGLSGPVEELNMKDVRAQFQTNVFGTIVLTQSLLPYFRARKTGHIFNLTSVAAYWNYPGWGAYVASKAALDAFSESLSREVEPYNIRVIVILPGYFPTKFFTETRSAEQLTTVYTDPTQGYKTREMIPQGRHEGGQVGDVDKFAQRTYEIVYGTGMAKGLVESQGGKREWMRLPMGTDCGELMLAKINIVKENVESFEPIWRSTDVERERLNDFAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQI3</accession>
    <name>A0A401GQI3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GSKIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0603980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615332.1">
        <property type="nucleotide sequence ID" value="XM_027759531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQI3"/>
    <dbReference type="GeneID" id="38781336"/>
    <dbReference type="InParanoid" id="A0A401GQI3"/>
    <dbReference type="OrthoDB" id="5804279at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11106" checksum="FCEA84DB14F9A9F9" modified="2019-05-08" version="1">MASDPPDGESLPFVYSELTNALREQEAFGIKNAAITHFSSFEAVAHVVLLEGRTVVVSLTSGGYTLGVEPNTTFETIEALLQCVSPMYLAARQAALSSKLDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQW3</accession>
    <name>A0A401GQW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0606200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615554.1">
        <property type="nucleotide sequence ID" value="XM_027759753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQW3"/>
    <dbReference type="GeneID" id="38781558"/>
    <dbReference type="InParanoid" id="A0A401GQW3"/>
    <dbReference type="OrthoDB" id="2789199at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.10.10:FF:000007">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="12">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="13">
        <location>
            <begin position="634"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="272"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE84641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1204" mass="135852" checksum="2A816541BCFD50FE" modified="2019-05-08" version="1">MDPQAQLAALAAGLPEDTYHALEAILRDLDHRVTHAQAPALSADNIRIALEHGFANAQFNLPPAHFTLPPAPPPPPVSVHPGQFKVDLAHFHGKDSDDLGAWLTLIEDYLRGQHIPEVDWPLQVPMLFRGEAQRWYVAQKKKIGRGFTWAELRKALTDKFDTPLRVETLRNELRSVPWKGNLTRYAAAFRDLETQIPEVDMTFGDRLSNFLSRLPVEFAKDIRRDKPKNVEEMYFLAREIERLSNLHHVPAQHQNNTNGFCKKTKGFTHHLFSSSSSSPSAASSSPSAPPTSSSPSTGPVPMDLDAMEQPPPLKTKDRVSRVRCFNCNGLGHYSRNCRLPRKRRPPQELNLFEGSEPPLFTDCCEEPLELSVLDLSDDAPEPHLLPTYAVQLAPSVNAKPLQLASAIIDTGAAYCYIKPSVVRRANLTTYPMMAHSVRSAGATTTSAWAHFAIKIGGWQKPICAFILDTDTLRFDMVIGQEWLQKYNAQPDWATRSWFLTDPRTCQVVRLHAMTVQQPLPLPRIAGAAASNRWASLVAAPLELYSLAEEPVTESPQETSGHKSPLAKIKSFGARLHARMKAKFPRLFRTKLGAPPAGRCEHVIDVTGTRPIRAHGRPLSPPEHEEVRKFVDEGLQDGIIEPSKSPWSAPLILIRKKDGKMRVCVDFRQLNNFTVRNAYPLPRIDDSYQNLRGARFFTTLDLRSGYWQIPLSAASRPLTAFATRFGHYQFCVMPLGLCNAPATFQNFMNDLLRSRLDRCVMVYLDDIIIYSPNLPQHLADVDWVLTRLDHQGLILHEDKCQWVQTELTYLGHIVSIAGVRPNPEKVQAITEWPRPDNVTRLRGFLNLTGYYRRFMKGFAKIAGPMYDLLKGNPRKRAEIKWSAPCEQAFVALKSRLTSAPLLSYPSPWRLFVLDVDASGHAIGGILHQSQNDFPKGEGDCSRFAFKESDLRPIAFESRRMTPTEQRYSAQEREMLAIDHCLQKWRSYVEGSPVVVRSDHESLKYFLSQKHLGRRLARFADNIAHFDVLIRYHPGRNQLAADALSRRDGQADVPDYEASGPLFANPMEPAVDHDRSALFETLKKWREDLLRDASAEPSRRGFLVRDGALFHSVDLGQGEVFLPVLVNLDEALRVIREVHTDLGHLGVRAVAEALKSRVWLPIVTELVEFVIRRCDACQFTQRELHLPSRCTHFLVRMPLIVGLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRC0</accession>
    <name>A0A401GRC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615691.1">
        <property type="nucleotide sequence ID" value="XM_027759890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRC0"/>
    <dbReference type="GeneID" id="38781695"/>
    <dbReference type="InParanoid" id="A0A401GRC0"/>
    <dbReference type="OrthoDB" id="2730545at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="332" mass="37783" checksum="33CBFCF4EC58BA04" modified="2019-05-08" version="1">MVTHLYDSSTDSPEVQDARLQPARAVTDAHIPCLVWAEDALSFVHCVPTVLFALQILVPDEYVEAAATAIVSHLPYKQMTEPDSSWLDYRFVDASEPSCFPWSVFLQHISPHERAEDDPEKIFVHPQSYFSVDVRDPSLSVSLVPPLPAHNTSIRFPILAAFLDSMIATQLEPPIGYRHWRFTQRLKVYIGYLMTYSPALRADPRVLPNGELEPGHAKVMNSLKAENRHYLDMALRGTSKGWLPEVQERRAILEKIGRFAEAPKPLPKVKRHPSVRHFRTLHTSARTQLGSSDEIGLRRRCHMSTSFAIGPYAREMMRFRRRVPSVISLGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRV1</accession>
    <name>A0A401GRV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615793.1">
        <property type="nucleotide sequence ID" value="XM_027759992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRV1"/>
    <dbReference type="STRING" id="139825.A0A401GRV1"/>
    <dbReference type="GeneID" id="38781797"/>
    <dbReference type="InParanoid" id="A0A401GRV1"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1029"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1064" mass="119982" checksum="5FD3A8262E2BB49A" modified="2019-05-08" version="1">MCIGENCAPQAAHYMNAQLAALHANAISCMRDHENAQKRDDIYRYSHALAHFSHSKYDIADHDDQDDAVFDADFGTPQIKFICNHDALLYLKIDRADYVVDHSAGMPSSSVCNLEVVFRVSFVCTKIIGTDSQIGSGQNIIQLVVLDLRKARLVSITPPLLTNQGVLTSYLSQYLEFLHKAGNHVLFSLPNFDSHRPQLSIDFSLTQSTDLTLDGIHGISLKEINHHLVSVWLRAAMSASEENVDWRTQCLAELRSYWIHPEDSNVHFRINFGTPYVKAVCNREGIMYFKIDEVAFFSSIDFTSTPMARYHDWTIAILFDIRYETQADGNVRDCALDTQTARFCESQCIFAGFDEEYATEEEFICWSTVTEFFKTEYSELLESASYHIIYHQDKRIDQQLTVGAWAALGDRAASSEISTWKDIVSNSNMFGFDQIVALSQTAINEYYSSLLYIGKTSNTLSLVTWAYQESFSATFKPLSLRFLSNNKAIIWIHFDDCSTLKTSDQVGDEKCDIGGWRLAFEVDLKMCPHTDFQDVSERWRCRFESSQAFKHHSCDADCSFTHLCLDFEHADFIHEYSTLKGLFQKGTSKPIERLKSAIYYIKSFYFRALAEDGLNILYTVPVWKCGSCPPAYGLTSIMFHVYSQEVITRHNWSQTTAAVEPVIVLLGMTEFRKPPSTQLEYSSSWLIRTKTSLSYGTISIANCVFMKARLLHRLTRINGATTLIPVFSGVEDNVWNLQFTRWDQHDTRKNATCEWKREYGREGFAVYKWQHREGWSYDHESNREATNGSYNVSCFTQNYLEIPTVNRSRTFEIRLNGEVKLELSFKSGTQLWAAKCSAKWDAVLAIASESSGLKIKESGRPTPVLDRTEVDGQYTAMAAEYTDPRALLKANLPSRIDLTEVLGELRAFEGPWQYCYPGTYSYAFANPGFNQRGDILFETRPIGLLAPSNPAARQSRISGVGLGGRRTPPISPLRSPSARSPFGSRPGTPALLDVRRVDAAFARSNPNTLSVVTNATTALLNTVSSGSKTTINYSEETPTPSDVSNEDDRGLNVDGVTIGVEVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS93</accession>
    <name>A0A401GS93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable 54S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0702590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615986.1">
        <property type="nucleotide sequence ID" value="XM_027760185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS93"/>
    <dbReference type="FunCoup" id="A0A401GS93">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS93"/>
    <dbReference type="GeneID" id="38781990"/>
    <dbReference type="InParanoid" id="A0A401GS93"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="4">
        <location>
            <begin position="187"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="298" mass="33288" checksum="5B08E9760F543308" modified="2019-05-08" version="1">MSAAVAQVLRISPAVRSIRPTKPPPRIRRPLPRDENRLPIPHVNLVVRDTAPCRLLDHYYNTVRDDIMYMTYKHQPNPKPPRHVRPKYDPEDPYTKHRFNPPIGGNQYFKRPPPLVTPENVVKLERIQLHTHVKESFSSRSHLLGAMMAFRAISGQNEDSGNQHTVEGVELAVGRRSIQGWVRPGAPIGVKVDLKGPRMYDFLGILVDFILPRIREFPGLVMDGASGPLNSPNAASGVVSFGLPPEAMAFFPQIEVNLDAYPKSYGMHVHLITSAKGVGAQNVARALLSGFQVPFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSE3</accession>
    <name>A0A401GSE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0703340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616061.1">
        <property type="nucleotide sequence ID" value="XM_027760260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSE3"/>
    <dbReference type="GeneID" id="38782065"/>
    <dbReference type="InParanoid" id="A0A401GSE3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="345" mass="37932" checksum="45E71BFD820C33B3" modified="2019-05-08" version="1">MNSEPLPPGPPQIRGDARQQPPLRMSASVQSGANALVALVECEKAKVRDALQKEHAEREAEFGRAQEIATKALTEALVRAHSAETGVKAAEARAHAAETELAQAWARAGPADVERTKAQADALRTTENELIQARLDTLRLTEDVTKLRHIVQDHLDELEVYKARCTKLEMEHAESVATKDSEIGSLTNQLLWLDAELRDLKARTAHIDLAAGHDTNSFSVANESGLTADMSNSAAIPDECNSYEEIFSQFVHDSSPGFESPVNTFSTLAVVVDNTNSSSHVDRSRGPALSPKSVADVLHPTASKRQLRIRPQETTRKKRVTRPRVSPPTEEERNRILYLTNDAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSG6</accession>
    <name>A0A401GSG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0702950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616022.1">
        <property type="nucleotide sequence ID" value="XM_027760221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSG6"/>
    <dbReference type="FunCoup" id="A0A401GSG6">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSG6"/>
    <dbReference type="GeneID" id="38782026"/>
    <dbReference type="InParanoid" id="A0A401GSG6"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="528"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="580"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="667"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="899"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115028" checksum="ECD5B2EC0A74310E" modified="2019-05-08" version="1">MLTESSSVVGGDSESEDDFDWEEVIVPEAQAVEEPVVLQTVADDVQEGPSARPSGNIEITIQAKTKKQGPLKKSAKGEQLYAQRLVRLDCHKIHTVCLLANARTRNKWINDPLLHARLMSLAPLSLQNAFALIHKSRVPEAAQRGRLFEAAINRLTEWWSASFRVDPTGHIRSRTFEDVQQRLGLSLSADPAEARRRAKGKERAIDVDEEDAEVIRSEKSLMKHALMFRGSRDASAQLFTALCRALGIPARLVVSLQSVPWQANAGKSKSTAKKKGKEADGKGNDKEKGEGKGKEKAVNGEAEEGETAEDDDMEEVVIPAGASAMSDRGTDKGKGRAMEDDIFPVGGQRLDGGSIPAVNGTPKDKGKAKAPPIINLRKSRGKKLGSAPNRPPRRERTPDPTTSPPVFWTEVFSRADARWLPVDPVRCIVNRRKVFDPTPNASALTKSDRNRPVRVENRLVYVLAFEEDGYARDVTPRYAREYGAKVAKVQQGGRGRQQWWEGILGLVTRPYRLNRDDLEDDELQIDQLTERMPTTMTGFKDHPLYVLARHLRRDEVIHPLREIGKFRGEPVYSRSAVLSLKTAENWMRQGRKVREGCQPMKWVKQRAMTVNKKRAIEMALAEQKDKHAAAEEDGGDGFASEGGVMQGLYAENQTELYVPNPVIDGRVPKNDFGNIDLYVPSMLPAGGTYIPYKGAAKVARQLGFDFAEAVTGFEFKKRRAFPIISGIVVAAENEQTVLEAFWEAEQDAEEKRRAKREEQVLKRWTKLVQGLRIRQRLQEQYADNNVRESSIVQEEENKDAQLEAGGFLTGADDVVQPFTLPKNLHEMPRTSTTISLAPSRDTRSASLKLDEVEDVQTPAAAYTLTLDENHDEDEDLEEIVVPIHMQPGTAIPKSIRELAEDAARQQADLSHEEEESRPVSSLAQDNKSDATKGTSTPSRSARSTRSGTGTPAATSRKAKASAQPSPRRSRKRPRKDADNEDAESEPEIATASPSKRTRASAPGSSDRVLRTRVPKSATQVQEEKDMELAYRRAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSL6</accession>
    <name>A0A401GSL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0703920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616119.1">
        <property type="nucleotide sequence ID" value="XM_027760318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSL6"/>
    <dbReference type="GeneID" id="38782123"/>
    <dbReference type="InParanoid" id="A0A401GSL6"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF11">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13420">
        <property type="entry name" value="Acetyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21833" checksum="6591452515E4EF8D" modified="2019-05-08" version="1">MIFQFNATTSTITELQFDTVVTAGYETKLWHIPSVQRGASSDYVGSKQHVTLGHPDALTVLKAEITGVMPEERKGGAVYGAHREIVGWCSLVLTDPKNRDGVLSVLVDPKRRECLRDMLTFLVQHAFREHGLHRVSATRYDGDDGVAAVYKDCGFTEEGRRRRANWVDGAWRDEILLGVLEEEWAGREPHEQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSR4</accession>
    <name>A0A401GSR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable di-and tripeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0704420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616168.1">
        <property type="nucleotide sequence ID" value="XM_027760367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSR4"/>
    <dbReference type="STRING" id="139825.A0A401GSR4"/>
    <dbReference type="GeneID" id="38782172"/>
    <dbReference type="InParanoid" id="A0A401GSR4"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="670"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="928" mass="101468" checksum="A8F3994422F08C87" modified="2019-05-08" version="1">MASSPTTPDPSLSRPLNPISKPPRLFHSLSQEQNSVLSLAADAEHIYSGSQGEVISVWDKQTFTLKTTLQGHTGSILVLEYAADKQWLFSASGDSTIRVWSTRTLSPLYLINPHLETDSGDLFSLVWSPTLQTLYFGCQDTSLQWFSFASLSSSISPNLAHSFAYGTSVSGTSTPTSRRVHKFFDSYPQYTRRPADLNARNPTCSSHPSLPPTPPRSLSTFSGRSSSPDTDSCVRQEPHVIEHPLAVFQVPAANVIYSAHYGYVYCMALVPSIREGSEDPPLRTAEEGEQRSVQLVTGSGDETVKLWNLSLATSSVPVLMHTFECSSGAVLSLVARGDTIYAGCQDGHVKVWDLETRTLVRTLIVVENVDVLSLSMLHSDLYTCSANGQVQRWSASFDLTASWPAHDGIVLSSIITRLAPPSPLPLPNSDSVVLSDANQGFVLVTGANDDHLKVWEVEPPKMRKHSTSTFNGIQERSDKEESRCNNETMIYALSTFVSIPSVSNCLTNREDCRQAAIWLRKCFSQLGADASLLPTGDNTNPLVLATFRGSQTKQRKPRVLFYGHYDVISAPPRGWSSDPFTLTGRNGYLYGRGATDNKGPVMAVACAAADLLSQRALELDLVLLIEGEEEAGSGGFGAAVKRHKDAIGSIDAILVSNSTWIAEDIPCITYGLRGVVHCNVEISNKGPDLHSGVEGGAAVEPMLDMVKLLGSLIDEKNHATIPGFYDSVRPLTDDERQLYTVLSGITQTPAQLLASRWREPSLTIHNIEVSGPRNSTVIPATVKAHVSLRIVPDQDLTTIAQALCDHLKTTFARTQSPNKLQVSINHTADWWLGELDDPWFRALEDAVRDEWGTEPLRIREGGSIPSVPYLEKEFACHALHLPLGQSTDQAHLPNERISLSNLYRGKLVVERFLLNVARSNLSGSALED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTL5</accession>
    <name>A0A401GTL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0800880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616484.1">
        <property type="nucleotide sequence ID" value="XM_027760683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTL5"/>
    <dbReference type="GeneID" id="38782488"/>
    <dbReference type="InParanoid" id="A0A401GTL5"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="35"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="661" mass="73225" checksum="95076DF542D68B58" modified="2019-05-08" version="1">MSSGNEEATPNVPAKAELNAEGFPSFSEQDIGEAWTKCAACLEQHDHQSVQSWKEEIDTLLVFAGLFSAVLTAFNVQSYQLLQPNPSPDATIVLLAQISTQLSSFSVNAGFINSTVPPLASAAISSVQAQPVLSSSVRINALWFSSLICSLSAASIGIMVKQWLSRFTNMLANASRPAARTRQLRNESMKTWRVANIIMILPILLQGSLVLFLAGLLELLWTLNDTVATVATVFVACLGVFQLFTTVLPAFVPTCPYQSPQALAFYIFVMLLKAPAQKWRTYLGWTGHQLDDSQLVLYNKNWWAYTWAERERELVDEFSEMLDVRMLIAADLVLADDTFLETAIRPCLGSMEPSEAAQSLVHIVGHCTRTQVFSSTRILKWDRRVGVFLNLVVDVMSRLEDGDSLDDATKTLLQFLEEAVYLIIHDRPTLQRLHDVMVTLLSKDTVGNTIHSRAFSVIKRINHLTGQISGIKFTANYTGLRAIARYIRYHLDNERISPDALGVLLRCASRPGCVLDAHLRAVHAELLQAMRDCFQSWDPVPLVDHPRPAMLRVGSCFVKLAHRVGEYVDSELIEELIKMFSRYEAMPVFTGEDKRDRAQTVPLLRDLQTLKSNLASSQDPSSEQANVKPSGPSQSSPSSERREPPGVSLSTVSNGALGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU75</accession>
    <name>A0A401GU75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0802780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616669.1">
        <property type="nucleotide sequence ID" value="XM_027760868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU75"/>
    <dbReference type="STRING" id="139825.A0A401GU75"/>
    <dbReference type="GeneID" id="38782673"/>
    <dbReference type="InParanoid" id="A0A401GU75"/>
    <dbReference type="OrthoDB" id="3270417at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="167"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="36939" checksum="87DBD02F2AEBC45C" modified="2019-05-08" version="1">MATITEEMLEGLLVTVVIAVFLYGVATAQVYFYWLNFANDSLWIRSTVLLVWGLETIHTGMCVKMITEYTIVDFGDLPAVAHIIWSAGVTVMLSVLIAAVVQTFFIRRIWILSRRFKLVTVVPGVLLFIRVAFGLATASLSYLLPAWIEFRASIGPLFTVTCGLSLSALVDLIVATVSIYYLWHSRTGFERTDHIIRSLITYVVNTGALTMVVSVSTLLTFVLLSDNLIFVGLAAVQSKLYANSFMATLNARKLRICGEASVQAYNSNSIELGPTRGEGAQTDHKTRKPIEIFQHTTNISDAIGGSVIETNSVAQLKVVRSSSELGETYQKPPSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUX6</accession>
    <name>A0A401GUX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616906.1">
        <property type="nucleotide sequence ID" value="XM_027761105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUX6"/>
    <dbReference type="GeneID" id="38782910"/>
    <dbReference type="InParanoid" id="A0A401GUX6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="5419" checksum="5D856D45E9AE8B94" modified="2019-05-08" version="1">MAIAVMVKGALVEGDLTGEEKLVEDQGVSSEPLKMESIPVGQQMDEDVVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVB8</accession>
    <name>A0A401GVB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0900450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617081.1">
        <property type="nucleotide sequence ID" value="XM_027761280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVB8"/>
    <dbReference type="GeneID" id="38783085"/>
    <dbReference type="InParanoid" id="A0A401GVB8"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="39517" checksum="752656BA389AE687" modified="2019-05-08" version="1">MVAVLGAGTRPRFHTALLKWALRARHQHPLLPSVSRSAVTGSLRVSPEKEMLLSLCRHTICDFFHRVKFTVVPYTHDPELVSQVNNIVQTWDTAVALRPHVVTAIGGTIAAYSHITNIETKVQIALFTTIILALDDPDILDSVPSREFHHMLFSRMAESSSGLLGELRRLLPGMWDHYSRFAASAIVTSALDFMNMTILENETREMSLSSEGAAFLVHRRTRTATAEAYAHFIWAKAKFPDVNVYLQAIPDVMVYVNCVNDILSFYKEELAGETGNYIGDRAAIERRTSMEILQEIVDETVATAERIWHILGEGDARESWESFARGYISAHALTPRYRLHEVLDRQYLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVG7</accession>
    <name>A0A401GVG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617092.1">
        <property type="nucleotide sequence ID" value="XM_027761291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVG7"/>
    <dbReference type="GeneID" id="38783096"/>
    <dbReference type="InParanoid" id="A0A401GVG7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="88" mass="10050" checksum="CCDE52216DF59330" modified="2019-05-08" version="1">MPLYSHTVKFVSHGANGAQTYTCAARQSGRELNWNNGVHVTKQSPIQSKVQQVLTTYRSVLSLHFNHSIILRLKLPDDFYLPLEPLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVM5</accession>
    <name>A0A401GVM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617190.1">
        <property type="nucleotide sequence ID" value="XM_027761389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVM5"/>
    <dbReference type="GeneID" id="38783194"/>
    <dbReference type="InParanoid" id="A0A401GVM5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="181" mass="20892" checksum="A9DE3865980C93CD" modified="2019-05-08" version="1">MAFTVFHTEEYIHTAWHTCVTHPALRSMRPSESIEHRWSQQASLISSIQAFSPLRWICMSQRGLLSGRHCSYNVQAVSRNIQFLYHNQYRLHTLHERCYSGRRYGICGKQDSTPQATAPPVLPSTAKHVNLVPVEIIPFTGIPGLVLGSSTNSWIFMHRQKHFTYWGSYPMMSPRYTSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWP7</accession>
    <name>A0A401GWP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0904820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617516.1">
        <property type="nucleotide sequence ID" value="XM_027761715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWP7"/>
    <dbReference type="STRING" id="139825.A0A401GWP7"/>
    <dbReference type="GeneID" id="38783520"/>
    <dbReference type="InParanoid" id="A0A401GWP7"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="177"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="445" mass="51235" checksum="6AB70ABEDE5A6F90" modified="2019-05-08" version="1">MLDFNYINPTALPEQYREHLPSQAEWSTERNAHFIGGRPVFIRPDNHNFDYSPEEFERTLPHNLGGIVLQHIADSGITTSYPGERPDAPWNPPAQNPVPQPTLAPIVPDYIPPMATVTMDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWREFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQAGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWQ2</accession>
    <name>A0A401GWQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617107.1">
        <property type="nucleotide sequence ID" value="XM_027761306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWQ2"/>
    <dbReference type="GeneID" id="38783111"/>
    <dbReference type="InParanoid" id="A0A401GWQ2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="237" mass="25801" checksum="E6362FBD2300AEAE" modified="2019-05-08" version="1">MFSEHHGWVQTGNLKADVRRSFSCPVAGCNYQAEIHRYLIDDHLRETHGEPAIQCPYIFMSGSTSAQCTYTTIYYTSFRGHLRWKHGQCLGDYGGMREILEAQRRLHAPEPAHPAGANPTFTLSTTECSRSTWAEPRTGTADAKPSWPALAPQINNMLYARPDISVDASVKIEDTASSTIPMWGALEGAAHRQPVHASGRASGELPVRGNPALEGSYTLDLPDRCAQGSAAGCNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWR2</accession>
    <name>A0A401GWR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0904910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617525.1">
        <property type="nucleotide sequence ID" value="XM_027761724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWR2"/>
    <dbReference type="STRING" id="139825.A0A401GWR2"/>
    <dbReference type="GeneID" id="38783529"/>
    <dbReference type="InParanoid" id="A0A401GWR2"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058504">
        <property type="entry name" value="DUF8191"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26609">
        <property type="entry name" value="DUF8191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="238"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="532" mass="61129" checksum="362FCD5C94B8372E" modified="2019-05-08" version="1">MPPSFVTSLTSNRRSNGNFRQRENPQQTAGSSSSRRRRSRSPEPRVVEESSSRNDTHNGRRKKKPSTNEAVVCSSAHDDVPMDRDCRAKARTSRVLFFAEEGDGPVTREHARDRGTGNSRGKRRERSRSHETSQRPSRKTASPEPMDDDSEPQHTTYCGPLAMADFHRMRHELEALRKEKAVSKKTIAKQSRTIDELRKEVTNLTKSEKERSKEIESMRNQNKKSDEIVANFEATLTCPICTDVLSKPHGLSPCGHVLCQTCLQEWFRSAPVDDDDMYDDEDPPSILDRKKTCPSCRASVLSRPIPLFLVKSLVSDVEKAKTPANTPRRPSPPREDEGDPWADIFREHVHGGWFTDDDEQDRDEDDEDEDEDYDEEDNWSYEGYGSGDDEEHYEGVYVRPRWSPPTVHAVHNDFAFMDDSEDLDIAMLRRGATLQMIDLFGMSYTHDTGLRAIVDINTTVYLGWNIFLHPDDESGEEYMDWITADMYERPERWDFEDDDRGNRTAWKLVPQDDDEEYSTTDSEAWVADLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX24</accession>
    <name>A0A401GX24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0901930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617227.1">
        <property type="nucleotide sequence ID" value="XM_027761426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX24"/>
    <dbReference type="FunCoup" id="A0A401GX24">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GX24"/>
    <dbReference type="GeneID" id="38783231"/>
    <dbReference type="InParanoid" id="A0A401GX24"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="92"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="221" mass="25304" checksum="850065066B5DB2D2" modified="2019-05-08" version="1">MTSKQFTLYTHKTGTNGWKVAIVLVELGLSFDSIYLDFTEVKQVAHTKFNPNGRIPTLIDHSNNDFVVWESNAILIYLVEKYDKEHKISASSLEDKATQLQWLFFQASGQGAYFGQAAWFRNYHHEKIPSALERYLRETIRLTTVPESVLSKQAWLICDKLTIADLSFIPWNRYAFDHMIEGFEGFNLEKDCPAVAAWHAKLMARPAVAEQFALKDALAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXF4</accession>
    <name>A0A401GXF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0903330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617367.1">
        <property type="nucleotide sequence ID" value="XM_027761566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXF4"/>
    <dbReference type="GeneID" id="38783371"/>
    <dbReference type="InParanoid" id="A0A401GXF4"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019132625" description="chitinase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="49"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="34862" checksum="E9BC753E95CAB08C" modified="2019-05-08" version="1">MVARSLFGLVSSALLVLAQFSSVCCAPAAHEGRNDNARDISARSVPAAPYWVAYWDAYTSGVTGAPSVSALDGYNVFILAFLLLEGAWDNAEAWTELTASQRSTILSEYSAAGISLIVSCFGSTDTPTTTGADPTSTANTFAAWVIEYGLDGIDVDYEDFDAFDAGTAEAWLVTFTQQLRTQLPEGEYILTHAPVAPWFSPSIWTNGGYLQVNSEVGSLIDWYNVQFYNQGATEYTTCSGLLDASSSTWPESALFQIIANGVTADKLVIGKPATTGDASSGYMAPATLATCVETAQSNGWGAGVMVWEYPDAPSSWIDTVRADSWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXK0</accession>
    <name>A0A401GXK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1002030</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617871.1">
        <property type="nucleotide sequence ID" value="XM_027762070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXK0"/>
    <dbReference type="FunCoup" id="A0A401GXK0">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXK0"/>
    <dbReference type="GeneID" id="38783875"/>
    <dbReference type="InParanoid" id="A0A401GXK0"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="331"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE86958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="994" mass="113696" checksum="813C9C575BBF4B9D" modified="2019-05-08" version="1">MLPEEAQGLRQRRWDLSDSNETVTPLTKSDESNARKQETVVWGKTPGGEVFRVPTTHDVLTLFHPGYPKSHLDLLNLALLGMQLVLFFISPRSVSRIFFFFYFAFWRAAYDVGLGWVLTKQSKRKWIVRTVQKLGWLDEERKPAVRNWIRKQLAGKMGKDYSFDELPLEYNTWLLFRQVVDIILLNDFVAYCMFAFSCFRIPDDLSTTVHVMRWIGGVALIAFNLWVKTEAHNVVKDYGWYWGDVFFQRGALVFDGVFELAPHPMYSVGYAGYYGLSLIVGSYAVLFVSLAAHAAQFGFLVFFENPHIERTYGQRKPLAYRSPVIAALSQADVQSESHSRKDSSSSIEQTELSTPSATEGESATEPEELFTETETETEFETNFTSNRIKRLTGFSSPFNGDLLSYVPSRASSPPLSQHDLMNRYFRKDMVLLMNIDLLRSADFKLLLIMFYPLVSAVIPTLSYNSLLTLYFVHALAWCLFHSVGLGLLLRAQSENRFLVRHFLKHYHYPHNDRGKGALHEAFNSWKSIYNLSMCMTYISAICLAWKTYSLPHEWTVGNELLRHTMGTILIGLHIWSTMESYEVLGLFGWFFGDFFVEDFPSHLEYTGIYRYLNNPEVVSGAAFFGLALISGSKLVFALAVIRHLSQWWFLSKVENPHMRKLYGDSLRSDAGFVKVIKKVARKNAHLLESRAGRHAPEIRRVAREVKGTFDKVYEETAEVMEEFLAKSRPKISEVVQDTKILLQQSREKLVITRVANNLSSFDTRKYKMAIVPSSDGSLHFHLGEPIQVKWLAPSNHSRRDWIGIYRVGANQSNLVTKTSSLGMWVPVHDEEWDGDIPLSLNNHNSTEGEPEGGEVVFQHGALPWKTGRYEIRYHHDGKYNVMSLDGPFEVYVEKPESLSFATIRKCLMHIVPLCLDSDESLIPLSCKPEEARQVEQEGRDPDDFRFWSERQAKRISGAIRQAFGVELTPEVIVADANLSALTNRILVAKELLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXL3</accession>
    <name>A0A401GXL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate esterase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1001640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617833.1">
        <property type="nucleotide sequence ID" value="XM_027762032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXL3"/>
    <dbReference type="GeneID" id="38783837"/>
    <dbReference type="InParanoid" id="A0A401GXL3"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019024271" evidence="2">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="37758" checksum="4DBAB5E2E917B2E7" modified="2019-05-08" version="1">MAILNLLAACGLLLGSAQSACAFGYGPLPGQIKNLVTFGDSYTDVVSSQLIAAIYTSYPATQAVPGDHGIAWPIFAAEDGNLTLYPFARSGATCSNNLTARPFPSVFESQLPTYFEEVANGTLDLNPHDTIYTLWIGTNDVGVDALLTGDQTPGVTVVDTVTCAVNWVKVLYENGARNFLFQNMLPLQNTVLYAADSYPNHYWTYERNTTEWNVFMTELTQTANNLSALMLQSLTPALPGAHIGYFSSYDLVSDIINHPANYLNGTAPLNVTGCVNACVYQLNGNSSGPAACTVANGSDAYSFLWYDELHPSQQTDGVIGKAIAAAITRTSDQWTTWLTSVNEERGPKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYC7</accession>
    <name>A0A401GYC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1004480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618114.1">
        <property type="nucleotide sequence ID" value="XM_027762313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYC7"/>
    <dbReference type="STRING" id="139825.A0A401GYC7"/>
    <dbReference type="GeneID" id="38784118"/>
    <dbReference type="InParanoid" id="A0A401GYC7"/>
    <dbReference type="OrthoDB" id="2794527at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="38"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="489" mass="55625" checksum="879F1CE764377F7F" modified="2019-05-08" version="1">MSDYGPSPSAMKRLAIPRPMDESGIQAWSKSVETNVGRRLIVALDGTMNQFGSKNSNVIEIYARIQKDEHQLTYYNSGIGTYADPYHSSPWKRLKLKLSSLLDMAFALNFDKIILAAYRWLSENYRPGDQLFFFGFSRGAYQVRVLAGMIARVGLIHSGNEEQIPFAFELYEQGDDAMAERFKVTFSHRDVQVHFMGLWDTVSSVGVFRRKKDLPGTPDCKDVHYVRHALALDERRVKFSPEFITPTVAASHSDSADPAGTERLPDIEKDGQSNRPIRVKEVWFAGCHSDVGGGNKPNDKLLMDAIPALWMANEARTAGLDLLPTKVEWDLEKLKAEKPTESLTRPWWILELMPFLSRSEDCPDLEQLDKLPWLYSRFTHFLHKMAPHLGGHRFIYPHQKIHASVVLKTEYAPRAQFMPGGVRPHTWDTILREETIADMYMSHHKDIIEFDLYDTSSAGPLVKTITQGAAELELQSVLDRLLVLADFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYK7</accession>
    <name>A0A401GYK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1004910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618157.1">
        <property type="nucleotide sequence ID" value="XM_027762356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYK7"/>
    <dbReference type="GeneID" id="38784161"/>
    <dbReference type="InParanoid" id="A0A401GYK7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10375" checksum="AE75792C9770D4AF" modified="2019-05-08" version="1">MRCLEPRRQAPAMLTLPPVPPFLLFAPPSIHQHPRGDNRLLTDSSAHHPPRSTAPLPATRLPSPAWDPPAKVSRVLASLTSLASFSVAAFVAAGALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYL9</accession>
    <name>A0A401GYL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1004960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618162.1">
        <property type="nucleotide sequence ID" value="XM_027762361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYL9"/>
    <dbReference type="GeneID" id="38784166"/>
    <dbReference type="InParanoid" id="A0A401GYL9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019527180" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="21670" checksum="0D0D9B3ABAE8B5BA" modified="2019-05-08" version="1">MKLISSANGFAAVIVSVVVLASVDDVTSQSVIPTPPVVAPSSSASFFSSPFPTPPDVASSTPSDSESSSFSFPTDSAAPSSSDGALVSSTPSDVPSSSFSETSVTPTDVPGSSFSVASSVSSESSSLFSSTNAIGMPSSSIFTSQVSNTPPSSSRSILSASGTSSHSSSESSRSSSFSSHTSSGSSPASTHTNTNAAHRRAHAGFWVVVGAGAGALTLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYT2</accession>
    <name>A0A401GYT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618239.1">
        <property type="nucleotide sequence ID" value="XM_027762438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYT2"/>
    <dbReference type="STRING" id="139825.A0A401GYT2"/>
    <dbReference type="GeneID" id="38784243"/>
    <dbReference type="InParanoid" id="A0A401GYT2"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="411" mass="45571" checksum="B86BD0ACA91C3B73" modified="2019-05-08" version="1">MDIEYNDNWHTASALSSPTLTPLSELSDLLADALEEDPSLSILSPHKSLQDPSGSQSHTQQLPNPFSSQPDTDLITPSLAPAILSPTSSAPCSMIDHQCTESNSSDSSADLLAYTHPIQSKMDSTKTGHLIASVMQHSIKQAPTVSTGKLTPSVLLQWESACIQYFKKKSVPDDEKVSHVTGGFMDELVHDWYLSDSDTIDALKWPNFVSLLRKRWLDKNWEDAALHQLIHLRQCDDEPFKDWIVSLEKQNTLLCDSPLRMDTATLRAHISANACEEIHLECNKPVYCSLSDFKDWKDAITAFDNDRLMDHARRLHELDHYLCSNCSSAPSSSSLANCPAFASKTAPPGTDSKLRAVLPKLTDSDHALYDKYEGCYKCRCFFVKCKKNNCLNDFPDAATYQPLTAAAGFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ22</accession>
    <name>A0A401GZ22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SCP_1100870</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618324.1">
        <property type="nucleotide sequence ID" value="XM_027762523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ22"/>
    <dbReference type="FunCoup" id="A0A401GZ22">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZ22"/>
    <dbReference type="GeneID" id="38784328"/>
    <dbReference type="InParanoid" id="A0A401GZ22"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GBE87411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="372" mass="42649" checksum="5976E73152AD09A8" modified="2019-05-08" version="1">MSKRVRIYTLEDVAAHSSPSSCWVTRDGKVYDVTNFLPDHPGGDDLLLSYAGRDVGAIMKDSSQHDHSDSAYDMLDECIIGRIGSEADIVREDWEATDDFVPENTDTTADFEKTHFLDLRQPLLRQVWEANFSKSYYLQQVHQPRHTPESPRLFGPDYLEIFSRTAWYVVPIVWSPIASYIFIRSLVQFTLGNDSLPLFREDPLAPLIAITTTTIPLLSVVKTLLCFFLGNFVWTILEYIFHRCLFHMDYYLPDHPAALTVHFLLHGVHHYLPMDRLRLVMPPAMFAALEAPMTALAHALFPAAVANGIIAGAFTFYIVYDCMHYALHHSKLPIYVKEMKKYHLAHHYKNFDLGFGVTSKIWDYVFNTVLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ88</accession>
    <name>A0A401GZ88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1101540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618391.1">
        <property type="nucleotide sequence ID" value="XM_027762590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ88"/>
    <dbReference type="STRING" id="139825.A0A401GZ88"/>
    <dbReference type="GeneID" id="38784395"/>
    <dbReference type="InParanoid" id="A0A401GZ88"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="111"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="423" mass="48117" checksum="8F72EFBAC290A26E" modified="2019-05-08" version="1">MKVPQYVNDFEHHENVPMFCPDPFDVDVVETVTLTESGEPRVLQPISNARHVTLRERLAARAKNLPLPRMHIGESQRPHSKLPQIYDRVVGRLFSRRPRERPLPPLPATLPRHDCVICQSPIADIEIHAPCGHYLDPQCLVALVEASTGNQLQFPPRCCQRPIPFTQFEPYLSPSLAALYSEKEAEFSTRRRVYCANPVCSRFLGPRTRGPSFRIISCPSRCGTLTCNCCRAAVSNSEPAAHRCRHDRRERAVLALASRKKWARCPACEQVIELHSGCYHMTCLCGQQFCYLCGAPWKTCACVQWEVVQLRDVGEHLDVGPEVRHRASGRGRNERADVLWEAPRPVVCDDRLRPCPEVVRIASEKRPAPEFVENDPETWDASLVDDDVVIRGLLAQHRRRKRRRVNTQDENVYMASVSGGHYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZF9</accession>
    <name>A0A401GZF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_1102280</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618464.1">
        <property type="nucleotide sequence ID" value="XM_027762663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZF9"/>
    <dbReference type="FunCoup" id="A0A401GZF9">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZF9"/>
    <dbReference type="GeneID" id="38784468"/>
    <dbReference type="InParanoid" id="A0A401GZF9"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="374"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE87551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="482" mass="54877" checksum="7C7254FF2F65755D" modified="2019-05-08" version="1">MSSTAPSPQNTTRPETITPPLTPKPAVKDGKEEPADINIPDNYVSWTLKNQTSRPPITWDNWWQEMNWLNLSILTITPVIALWGAFYVKLRWETFVWSVFYYYVTGLGITAGYHRLWSHRSYNASKPLQYFLAMAGAGAVEGSIKWWSRGHRAHHRYTDTDLDPYNAHKGLLYSHIGWMLVKPRHKPGVADVSDLSRNEVVRWQHRWYLHLIIGFGFLFPTAVAGFCWGDWLGGYVFAGAARLCFVHHSTFCVNSLAHYLGESPFDDKHTPRDHVLTALVTIGEGYHNFHHQFPMDFRNAIKWYQYDPTKWFISVCEFLGLATHLKVFPENEVRKGQLTMELKRLRKAQEGLLFAPDLDELPVISWDSFREQAERRPLVVIGGFIHDVGHFMDEHPGGRHLVAKNIGRDATTAFFGGVYDHSNAAHNLLSMMRVGILHGGMQHGLDDKSVPPSQRLRIARYNESGLPSASSLSSSDSEGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZS3</accession>
    <name>A0A401GZS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1103440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027762779.1"/>
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    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="287"/>
            <end position="330"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="190"/>
            <end position="216"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="711" mass="77568" checksum="3174009B44A5C950" modified="2019-05-08" version="1">MTRHSLIPASAPTSPAVTRSKSDRHPVTPQRVVHPQLRQFNSPYTPAPSLSTVSTPYTPLSLRSFSSSNASSLATPASAISRRRMSLSLSPEINLNHKSLADIAENWRTRANENGIKVTSSDDSQYEADSSSLSDVNNSLIDKSLLPAPFFSTQRRERAYSQAQAPLSQIPDPTQFCTPNRVLRPPGILNTPPSQPSFRLRGSLTDPAHTRRRPPFDQTSELFNIDEDEYAPYPPTFSSSVSTQAIPLALTDPFGLHASIPANVEPIQFYETRKPPQESATDVVSACSVCGLSGKSLAILEPCAHPLCSACLTSALNIVGEKDMECAVCKAKVDDFKLCRSTSGKSTVAKTLESDAYIDHDDFARGMDAFAGASEVDMVVDTPAFCGFDDFMDRAQGASTPVAGRREIKSEEPVVLRIDNVPWDITPPAIAAWLNQPVVRVHVLLDRKGKTMSHAYAEMANAEVAQAALRTAQNSVLGKGKRARGVTVTRSSQEELMQALFPAWQGNFDGSRPSLSGLDNERVISTLQRGLFSEGELNALLHLIRSPDSHFLKVPSLPFHSLTSILSKFPSDDDSRVFWSSTLRDTLYEITYAAVQVLLVRIEENPLSDWTTLMGELVRAAMDCQAFTSDQMSKLSDILEASLPQSMSSPPGMHTALHTPSSPQSVAPQSHEGYNSPDLNTDRRTYNDLAKEFGVEADLIHALAQRLSGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZS5</accession>
    <name>A0A401GZS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1103160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="180"/>
            <end position="240"/>
        </location>
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        <location>
            <begin position="809"/>
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            <begin position="1068"/>
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        </location>
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            <begin position="180"/>
            <end position="190"/>
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            <begin position="213"/>
            <end position="225"/>
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            <begin position="844"/>
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            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
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            <begin position="1084"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1094" mass="119749" checksum="D28EFF9B34A110D1" modified="2019-05-08" version="1">MFCPSPVFHDITNPSDWPHKVQEVVHLLSQPLPNYISTGPWPFVSPLASYLLNELSQDAPRQRAFQHEGQSVTDSVSRLNKVFDLVLSTVAALRELESLEDCGPARPTVPLWSLFFKGVGIACSPESCYMDEVSFVLPQLSPRSSQVVFDGIATLLISHIVDESQFVRSRSSSDAMDVDAFSEPEDDQDGADASSSHNSERISIDGTHSTADSEGDYADDQDSTDETSQQPSGPSIDVPFDAHVLRGSGRRLFAVLPVICVADSDNIGALVTSVAYQRRVWDIDEPVVGFEVSKTGAVARILLGWVGAEVDGDFLPAVNIACATTHSYSGMTVGVFDLTDPQSALALAQFVLGLDAHCWRIVSKSKHRPVIDAFHWRSDYLEEHEDSCNNGDLGTRIANWASTIDTRGDGGNPEAELDLSTSPASDMSDLSMILESPGKPTEGRGRPTTPRAGSQTGSGAKKSHSRVKEEAVATKGRSRTPASDKASQKQELKAPKSRSASVAPRSERSSSVLAKKVTTALDGSVTPSTWLFERKAFPIALIKLPPNAEDADEINEKIDTYRKIVVEFAWRSGEWSSVDTMPQVDEAVQPVLERLFQNYSALKEKPVNLDEADMHILSSRFSTILYASMGAYTHHAASSGLRVNEAEARHDWDRMLYQFCVSDSGRIVSPYILLERELIFPRNKAVDLMLDDDSPEKWKSFAEKQEALALSYYTHCVAVQVPSVLHGPAVGQQAIAASGRALSFFHQIGSVSRDPSKMLDMFRKHAASEPLMGICDAIVVCGIKDAFDNKDSPATRKFLNEQALVQHTLTMRRKKDQSTEELVSQTSSHPQPPTPATEVRPKKASALKTTSAPKTTSASKTTSTRSRAPSAQSALRKSVGDPFMNSCSPLISKDQSNDNSTSPRDTDAITRDADAITRDQLLLPVLVAEYKRWDEDQAKSLNQGRFYCVASVTFLAALGIEGYPVFTLITNGKVGAVLLSWQSQGKKKKIYIIERNVCTFDLADPLQAFHFATFLVRLRRQHRELKALFEKEKANFRRKVSAEQFDEWMMAAQDVILKAQQAAADAAAASKADTDSSDARPAADDVPADSPTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0J2</accession>
    <name>A0A401H0J2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SCP_1201640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3063716at2759"/>
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        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="293" mass="33209" checksum="199C5BCC9ECFC843" modified="2019-05-08" version="1">MFPQFSNPHTLSQATKRVDRLALEDNDHPPSYEGAERTEMIAQLEGLLKRSFGNLTTSPRDQEHDTPRRKKRRIGADDVHLSESSPLPFRLVSRALPPKSILLKPKPPPAIVVQEPSCEDDEIEAERRRAQAQAVAVDFDWVMAESKQTYLPSKNDHKKVIHVQAQLATPEPIMMVVEREKPPPRKPKLALSLPPADFQPSPHSLPAQGVLCPVVDVTTPGLPEPKRKRCRKPHVPRPRPPAMFWRPFHGMGGKSAGYAMGYEGSWPVHENDPRCYTYQRDTMRRGSLMQSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0L0</accession>
    <name>A0A401H0L0_9APHY</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
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                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027763077.1"/>
    </dbReference>
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    <dbReference type="STRING" id="139825.A0A401H0L0"/>
    <dbReference type="GeneID" id="38784882"/>
    <dbReference type="InParanoid" id="A0A401H0L0"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF1">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="193" mass="21547" checksum="0C6D3B5E78C2D1AC" modified="2019-05-08" version="1">MSEGHETNAEVLKKLNVAKEKKETGDQAFKAGELQNALRSYHEALLYLNGIDKTPLAPLTAQTEPVVDGAAKAKPKTEVDEMLEKIYSNQSACHLKRGNWKRAIETADKALTQNADNYKALFRKAKALGELGFFEKAEKILEDLLQKNPSDAPAINAELTRLRAIDKVREKVHNQKFKGFLNRENKSEAVAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0X6</accession>
    <name>A0A401H0X6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mis12-Mtw1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618977.1">
        <property type="nucleotide sequence ID" value="XM_027763176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0X6"/>
    <dbReference type="STRING" id="139825.A0A401H0X6"/>
    <dbReference type="GeneID" id="38784981"/>
    <dbReference type="InParanoid" id="A0A401H0X6"/>
    <dbReference type="OrthoDB" id="3364649at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="66758" checksum="10854D0CAEE13B3C" modified="2019-05-08" version="1">MLPTHSQPPTSKRKETDDGNPLSKATKRLKKEGSTKAGSGSKRKLNGEEQPGGLVIVRAPSARPRSAQGGETLQVESVPQSRASSRPPSAPPHQRSTGESSKPPAKKFRADGTASSTRVVSKSKDREVFTSNRAEPEVDEDVRLMQSETDTLRRRSQAAEQSAGSLNNNVQFLPSKSPRPPSNQRVHDTSLPLPQQETPRIERNRFMRGEEPNHRRKRSLSRGKRISSSYENTGVISHPHTSVSDTSFHKHIDGDLPEPQRVCQLLIWCTHRAMNELTDLSSRAPSEQSSHASTSRREAKKPGRDPPPLSTDGIQLLKRVEEGVMKMLAEKKIDTNVYSSGGVLDARVTKPLRENEQNVKNRAREARFNAHNQRSRAEDLAWSKVQDNYNAYRSEILEEISKLESAKSKGKQRASADQLDEWEVNEYDLPPHFRGGENVGLARKIISAGSDGKSPLRSRLEELEYAMDRLHTIANSALHTTRMSEMDLDRRFALLNISLGARTQAAPSALPSSSTSLSSYLPPSLTRPSPTTDPQDLLRALSRVDAQRPQAQVGDAARRAVREVQRAHDATSGVAERRLTGVPPPTPRKPPGTPRRATTPGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Z0</accession>
    <name>A0A401H0Z0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619004.1">
        <property type="nucleotide sequence ID" value="XM_027763203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Z0"/>
    <dbReference type="STRING" id="139825.A0A401H0Z0"/>
    <dbReference type="GeneID" id="38785008"/>
    <dbReference type="InParanoid" id="A0A401H0Z0"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27676" checksum="C7E5C297060C5115" modified="2019-05-08" version="1">MGGMNYHVNIIFEDGVVWLCRIRRRDVSSPPTVLQNRILLSEAATLRYLSTTSVPVPKVYDAIADSPSNPVGVGYILMEKLQGKSLDWFDLDRDGKSKILEQLAQIYIELEKHVFPAIGCLEEGGVVGQLVNSAAADVDAVGDLQLMGPFTTSFKYRYTLVMHQLAIIGNGEVYASKAHAVDAYLVHRYLLDHMSLFVPQDEMEKSGYYLKHMDDKGDHILVDEALNILGVVDWEWAQTTSKREAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H128</accession>
    <name>A0A401H128_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 monooxygenase lepD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1203670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619050.1">
        <property type="nucleotide sequence ID" value="XM_027763249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H128"/>
    <dbReference type="STRING" id="139825.A0A401H128"/>
    <dbReference type="GeneID" id="38785054"/>
    <dbReference type="InParanoid" id="A0A401H128"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="519" mass="58524" checksum="BE7A6671B3B89B3B" modified="2019-05-08" version="1">MDAANSTMTFTSYLIPAVNAYASAPISWSIYALAAALVAVSWKLRRSFAQSPSSVPIVNGRGEALPHADEDTRFSRFSHGKEIGDQLLKELGPIYTFQAGKIRELVLTSPEDIKVYYKDALGRDEDKAHKKALGASFGDYMTRFLSKAVGFQYGYSWKRIRNSLDPHFVRKMALDAIPYMKSDFVEWIVALRSSPQATAMGPNPSDPFEIQAIAATKELPFKVISKSTYGETLTPDWYARLWALHPIHDECMANAIGNSYATHWWYRFMPTAANQSLRAFKDGYKSFNREIVAESEKRGHDTVAARMYTSVVDGLISEDEFHQTLDEILFANIDVTSVAQAWLLVDLGLYPEIQEEVRAEVLAVDESNPKALETYLSSTTNLLHLVHSESARLHPVLWYNIPEVISVDKTISGYRVPRGTSVCVSTYHLNTNPSVWGTDAQTFRPSRFTEMLPNKYRHAFWRYGLGPRQCLGKNFALLIVKLVAMKALRKYRIETIGEIGFDKAQFTVTPQALLRFTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1I7</accession>
    <name>A0A401H1I7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1300780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619176.1">
        <property type="nucleotide sequence ID" value="XM_027763375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1I7"/>
    <dbReference type="GeneID" id="38785180"/>
    <dbReference type="InParanoid" id="A0A401H1I7"/>
    <dbReference type="OrthoDB" id="2552152at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52056" checksum="B83A512A311F417F" modified="2019-05-08" version="1">MRGDAAERAVSGRGAPSVVRDDERGISSELGRKEAGGTSIRDVTWWDQEVRKRKFGGWIREEKFASVVEMEGGKERRWRQRSREREEAVSQRRERADGKLTVRRFDTCLSRRVYMSHAFFIATPFIPLFLSFSPSPAVSALSLFMSSKRGRKRNDNLPPNRARDVQRAFRARRAAHLEALEQRVAELEDENNALRAALNLPPANRAPLGKGPTGKDKPKSHIPGLQTSQSSTSSLPPISALPHISPTISNTRTDSPSSASDTRTQSLSPTVVGATLAQANQSVVPTLESANWPESMFMEKDQPEASTSTSSGYAMPSVVSASSSYPPSTSRQTFPEMYLQSVTQNYPHTADRPMGTETYSSHFTTVRDERRTFPYSQAAFPPHAPPMHSQSPHLPPVSSAMAPQGGSLSIPSPLSYTHRRSITEPQGYRNMLPQMRQAPPPPIRLPSPSMLPQSNAPNSVYDARKNDRMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1L4</accession>
    <name>A0A401H1L4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1300980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619196.1">
        <property type="nucleotide sequence ID" value="XM_027763395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1L4"/>
    <dbReference type="STRING" id="139825.A0A401H1L4"/>
    <dbReference type="GeneID" id="38785200"/>
    <dbReference type="InParanoid" id="A0A401H1L4"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="283" mass="32222" checksum="B701D26B42E14AC8" modified="2019-05-08" version="1">MTTTGIQARSRSLESFPIELLYEIQYYALSSSLPLTSKHFYAVFKSAPSSFHAQYLVGRYFHSERTTARRTTGLFTTVLRYPICSQEVLEAVVRSKFDEVSYPRGRKGVVIELPRRLFRTLAPRTLGGQGKPNHSNWSENDTPLPFLRYLYDHPRLPPPFIDSYDGYALTKAVYAGFIPLVRFLLAHGASPAYKDGIAVMVAIRRKDLALVRMLVERDHRGVNEQRTSCTGKGKRRKLGDRVRVNPQMLKAAVKCDARDIVEYLMREKGCIPDMQTVLLMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2B5</accession>
    <name>A0A401H2B5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1303640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619461.1">
        <property type="nucleotide sequence ID" value="XM_027763660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2B5"/>
    <dbReference type="GeneID" id="38785465"/>
    <dbReference type="InParanoid" id="A0A401H2B5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="249" mass="26585" checksum="E6D2B05AF02AA962" modified="2019-05-08" version="1">MGALGSLPPGIPNTPPRADGHPKHFHKLLVPWLCEGFVVQILWWQAEEACFCSLCSRSIRGFKIQSKQTIAQHKKRDTQQQAQAAESQPLVSRIGLHTVTTQADVALSEDQTGALDSTTGEIQESTHLLDDSGVTFPSAGDLDSPDSPEGSHCADQSSPAQSVFDDDVIPNDIPDELGAAANDGNPSREDAMVNGAESDAHATGGQDEDANAAGGQDEDAQERARLLEDDSGLAPAFREQPPWQLRSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2G1</accession>
    <name>A0A401H2G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1303990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619495.1">
        <property type="nucleotide sequence ID" value="XM_027763694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2G1"/>
    <dbReference type="FunCoup" id="A0A401H2G1">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2G1"/>
    <dbReference type="GeneID" id="38785499"/>
    <dbReference type="InParanoid" id="A0A401H2G1"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="77"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="38190" checksum="E3052D22E5737D69" modified="2019-05-08" version="1">MYSDRDLLRPRSYLLYVVLTAFAVLSAARLFLRSFNGLRSVHSHWHPARFSSFNHSTMALSLESKLKLRDGNEIPIIGFGTYEIEGREAYTTVKWALEAGYRHIDSAEWYANERQCGRAIQDFCKETGVSRSDVYYTTKLRSNSGYAAAKAAIQKSLDTCGLGYIDLFLLHSPIGGPEMRRESWRAALDAKAEGNVRSIGVSNYGVRHLQEMIRSGVELPAINQVDLHPFMTRTDIVEICKEHNIALEAWAPLVRGLRFNHPSIKTLAQKYNKEPAQILLRYSLQKNYIALPKSASRSRIQSNIQIYDFNLTSEEIAHLDSLDEELVTDWDPTKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2K0</accession>
    <name>A0A401H2K0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Replication associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1400620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619570.1">
        <property type="nucleotide sequence ID" value="XM_027763769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2K0"/>
    <dbReference type="GeneID" id="38785574"/>
    <dbReference type="InParanoid" id="A0A401H2K0"/>
    <dbReference type="OrthoDB" id="2977716at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049912">
        <property type="entry name" value="CRESS_DNA_REP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55464">
        <property type="entry name" value="Origin of replication-binding domain, RBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52020">
        <property type="entry name" value="CRESS_DNA_REP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRESS-DNA virus Rep endonuclease" evidence="12">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="457"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE88657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="541" mass="61224" checksum="3B2CF126A904DBF9" modified="2019-05-08" version="1">MPPKCRRGNNGHAWPHAGRRSTGSNGDEPAEGSGRAPYKLQSPKVLVMWPKAEQFDEEKVIELMRGLGEGIRLKIAHKDHADGTPHYHAYIEFQSQPSIRDAQNRLTVNGNKPSFQPVVRTPEKVWKYVGDSDKASTFVVQDYFPPGHFRPPPRQEVRSVATELAEAVEDGSHEQALEALKNKANHNYTHIRDMSTTSDEFMKYMLQHATSDYFKNFVNINTASKNAFKPPEVPYERPLGLVIDLEHYPEISDWVENELKPRLGKGSQGSRGKSLCLYGESRTGKTLFFRSLPGNHIYMHHLFNSTEFLSKPEADFAIFDDFRSLEYLPSFKCWYRQQHRFTITDKYKPKEMVTWGRPAICLENDDPRNGPKLTPGDIDSLNMNMIFVEVTGEHKLAWVDSEQVDLAKATAEQEALRATEEVAMVPLEGFSPPWSLADDSQSEDELFVANTEWESTLWGPEPVHEEPNFPEDDSSPLSSLDTESPPAPEAPMVVPRGIKRKRGSNPFVDDEAGVSGDEDEQEDDEDEDGHLEGFVVPDHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2S0</accession>
    <name>A0A401H2S0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619573.1">
        <property type="nucleotide sequence ID" value="XM_027763772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2S0"/>
    <dbReference type="GeneID" id="38785577"/>
    <dbReference type="InParanoid" id="A0A401H2S0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="89" mass="10123" checksum="B9D7F12AA7D154BF" modified="2019-05-08" version="1">MDSPDDYKFAVLSLSTDISDEHNEIQEVIRLLGSTLECFNQPNATSAPANYTRIVLEKVDRWGLSDSCGESLRRMHIHLGRAKDVWDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H397</accession>
    <name>A0A401H397_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1402920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619797.1">
        <property type="nucleotide sequence ID" value="XM_027763996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H397"/>
    <dbReference type="GeneID" id="38785801"/>
    <dbReference type="InParanoid" id="A0A401H397"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="15547" checksum="6F7A68B6B1A24595" modified="2019-05-08" version="1">MKYGTIQDKEEVEEKTLSEKLGAEKIRRTLVSPPELVQSTGGYLFRRPRKGLRQDRRAQSLARPYLGTYLHIYLPTATTEVMRPRVENAREGRDMQNGRRVYREHCVSKIVIPCMASEGAFLVFYVTLSLSGLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3D9</accession>
    <name>A0A401H3D9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619869.1">
        <property type="nucleotide sequence ID" value="XM_027764068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3D9"/>
    <dbReference type="STRING" id="139825.A0A401H3D9"/>
    <dbReference type="GeneID" id="38785873"/>
    <dbReference type="InParanoid" id="A0A401H3D9"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="116460" checksum="C06CE1A368F750C8" modified="2019-05-08" version="1">MPLSHLFRTCSLKSFMGHKRKKSALPAPLPLAASAVTFPSSELPSSEIAAAHSTSPASAALSDSTVPTIPPWTPPDSPSQSMPEAVVSPSPDTSSPIPQECRNGLHANRLHLNTTSDSSMSDVSVSTTDDDRVMRTLTVVSAQINKHGSSSKAEQALNALDDKVTTIQDQETLVTTLYAQIEPAVALEAVSGVKKSIEDGINLFLDGMPVLMKALDEVAEIHPFVQAAVLAFKAVLETKRQANDAKITALYVEMKDMIAVLIQLKNVKDVEDVGPGGITLKGRLQNLVKTTANDMKKCANACDAYSKLLVKILTGPLWENKLADFVSTFTERRTQFEFTLSIHIGRGVDEVKRKLDNLEHGKNMLLKFMRTYVPPEQRELVALVQKKGGTKAVMDNEEVLKELHSYGSRRPTKAGDTQNQAGHARGEDDFIELKSDLQQDPDEAVEKNLQTFERKFEMQKRQLIEEVERVVKRESDRIIDSVTSGPHDKVVDRGWRGTVEARHFVLALRHYYHEKTDGKTRKESATKSVLTPDPDAWALEYLSVKRLQSIIDALDEDAAGFITVAEANKLTEVRPLNWSLLHWIAYWAVGWRINATIYIRRINELVGKMFAIKEEVYATNGPYVDEYLHTVWAGITSLTCSMRPMTSSDNLQARFKSRMDAEEERIRTNLEAVRYNINDMETLSLITGPGTIEKVRAFSSIDIFKQQKLDLDQQFKTIWGELVRIFFTTVTQHGRSIFSRYIQLSTRKYDFGRPLEGDEEDELTRCRKSLTPTDARFYLTLYLYQFRTTAVHFGVLCDNCIGVIGGTRTICIDCRTDRAVRTVDICQDERCLSAEVRRSDLASPHLPSHAVYKVRRTVHDREFGQLDKEARVALQNARAALKDAAEVKKKQTKDAAKEDDRRAKLVNDKLKCIVCKKRVVRPCWLCMTCRDELFWLVRDAWTHFVSSDVYICLNCDPTDGITIEGHDKRHPLVRYQEEVAAKRPSRIEALERKLDAVDGKIARVDERIQQLLQMMTMGARTPSTVVSISAEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3I0</accession>
    <name>A0A401H3I0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619875.1">
        <property type="nucleotide sequence ID" value="XM_027764074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3I0"/>
    <dbReference type="GeneID" id="38785879"/>
    <dbReference type="InParanoid" id="A0A401H3I0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="245" mass="27440" checksum="471748C40762145A" modified="2019-05-08" version="1">MSIPASPTLVNGVPSRAQTPFIRASSPTPSIELSHASDEQEFATRLVSAIRVPVDFTDILVALRNRPQDRQAVVSMQRALEMVEWMQTARQELIAAEERTSRARTRVDQVWSLMRSTVTRTAQEIWREHGDEDIGHILGYTTNGIPASTPRSSPEPIPVRPRPPRSHVPIIPTGMEVSPNKDREPAGGHATDVEEIITSATAPDDDEDHNISCGTRNVRRELMLQRSSLVARLFFFLFPLRYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3N3</accession>
    <name>A0A401H3N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619926.1">
        <property type="nucleotide sequence ID" value="XM_027764125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3N3"/>
    <dbReference type="GeneID" id="38785930"/>
    <dbReference type="InParanoid" id="A0A401H3N3"/>
    <dbReference type="OrthoDB" id="3268127at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="275" mass="31460" checksum="22AC9D0628475356" modified="2019-05-08" version="1">MLLSSPPSTPSRSTRYQSISYGFFPLRSSPLASSSPPPEGRSPPLMVTQARRRSQYKAQLPSSPTTIRTRKSEPRRASLGGSQRAEAVVPTEEAPRKAFLRERFRQRCIERAQKDRERKIRGKRYMSDLSSDGADECMDEDDEDEEAIMDDELFRRIMSSANRKQQHSYRLSYSYDVGSSFDPDLEDLDEWEAQLNDVQPDVPVPEDYEEDEIAAYAEEYQLHLEDLDLEQVFSTSDLEDQGVDLEDAPMFTRTQDEGKGKEVVSAFDDDIDMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4W1</accession>
    <name>A0A401H4W1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1601140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620365.1">
        <property type="nucleotide sequence ID" value="XM_027764564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4W1"/>
    <dbReference type="FunCoup" id="A0A401H4W1">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4W1"/>
    <dbReference type="GeneID" id="38786369"/>
    <dbReference type="InParanoid" id="A0A401H4W1"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="370" mass="40684" checksum="C319690394C59687" modified="2019-05-08" version="1">MSKHVPKTERVLSVQSHVAFGYVGGKAAVFPLQCLGYDVDVVNTVNFSNHSGYGRFGGSRASASELAGIFQIMEDNGLLFPDRLLTGYIPGAEALAAVKEIALKLKQRNPELIYLLDPVLGDAGRLYVAPDVIPIYRAALPYATIITPNWFEVEVLTDIKMTDSASLRRAMKILHDEYRVPNVVISSIPLRAWLDDLLPAQIRPSSQHTDIDFLLCISSSSSPANSGGEGGAGRERMLSAHVQCIPCLPGYFSGVGDLFSALVLAHFHPDAAPAGAETPLSHAVSRALTKTHAILMLTDEHAQHLPEDERLPTDDELDAREPDRKIRRMRGRELRLIQGQDILRGATDLEPRRMVPWTTFWEDICCVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4Y2</accession>
    <name>A0A401H4Y2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1601500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620401.1">
        <property type="nucleotide sequence ID" value="XM_027764600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4Y2"/>
    <dbReference type="FunCoup" id="A0A401H4Y2">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4Y2"/>
    <dbReference type="GeneID" id="38786405"/>
    <dbReference type="InParanoid" id="A0A401H4Y2"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="36739" checksum="8999CD18A2C1007D" modified="2019-05-08" version="1">MTLGGTASDVTIWRIGHGLMMMTWGRPDIVCDDDAFDAIKSGIDALPPGMKMMLNSGEFYGPQLSIANVELLARFFEKYPEYADRTFLSVKGGFRYRSLEVDSSPDNLKRSIDAINAALRGTKRLDLFQSARVDSNIPIEEVVRTLAGYVKDGLFDHIGLSECSAETLRRAHTVHPIAVVEIEISPWTYEEETKKVIATAQELGVTIAAYSPLGRGFLTGIIKSPSDLADGDMRQSMTRYNDENFAHNFMLVDALKVIANKKGVTPAQLCIAWVCSLGTHIAPIPGSSNKKRTLENLAAGDVGLTTDEKASIDAVIAGHEVKGDRYFGDPNAHIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5R0</accession>
    <name>A0A401H5R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1701020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620690.1">
        <property type="nucleotide sequence ID" value="XM_027764889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5R0"/>
    <dbReference type="GeneID" id="38786694"/>
    <dbReference type="InParanoid" id="A0A401H5R0"/>
    <dbReference type="OrthoDB" id="2570975at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="265" mass="29868" checksum="44CEFB7381C5BA65" modified="2019-05-08" version="1">MPDVKHEDVMAYAPDLARTPVELIRKGLPGMHRHVPPILLGVRCDPPKTVLRKVKGMSVPDSRLAECPTHIFAVYGPSWGSTSPADRYLQKLRARRLVTYYPIHALMFLAHCGNLPPIEDYRLRLAILHVTPPTATVEAASIIRVPLVPIYVPAPVAFQLLEHYIYFSNVPHLEAELLPSELPPPPRAPGIISHDDRVAAYAYALATQQDMTINRLSRHAKLVYRLYQNVVWLAVKDSGLWAAINFTWESLTSAMRMMQQWGMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5S1</accession>
    <name>A0A401H5S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1701100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620698.1">
        <property type="nucleotide sequence ID" value="XM_027764897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5S1"/>
    <dbReference type="FunCoup" id="A0A401H5S1">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H5S1"/>
    <dbReference type="GeneID" id="38786702"/>
    <dbReference type="InParanoid" id="A0A401H5S1"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="297" mass="34668" checksum="8FDDAC41A712F8D7" modified="2019-05-08" version="1">MAAYFFASPVDVDVKLEGEDDRKKVELKGEKDKAISCPVYYDGDAVAGQVTVRVRDGKKFAHDGIKVEFIGSIELFYDRGHHHEFLSLSQELAAPGEMRAAQTYDFLFKNVEKQYESYQGINVKLRYLIRVTISRRLADVTKEREIWVHSYRMPPDSNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIKHMELSIIRRETTGAPPNQYNESETITKFEIMDGAPVRGETIPIRLFLGGFDLTPTFREVNKKFSVRYYLNLVLIDEENRRYFKQQEITVFRIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6S1</accession>
    <name>A0A401H6S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1801360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621025.1">
        <property type="nucleotide sequence ID" value="XM_027765224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6S1"/>
    <dbReference type="GeneID" id="38787029"/>
    <dbReference type="InParanoid" id="A0A401H6S1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="442" mass="48109" checksum="7FA5ADBC1CF3EB36" modified="2019-05-08" version="1">MAILLPVHSGSSSYAEYNPATPSSLRVASTPRSSGVATASTVSPRYGTRAVAGSKRKVVSDEDWEDEQGVQKRPKVEPDVQDLLPRFGALPSSSGSSKDAWASTEDATQMAENMHPQEESAERSAGVADNHVNLGISDEGEELEDWIQSFLKVPEVRAILLESRSSLPNDLLEETPVDPCLLGSMPDEVEQFFLDACEESTPPELVAPQVVRPRPRQPRCGFEFSTPLWKQACQARANIMLDIFGAASLCHEAASEAAAGSSSPQVCSHQWWEAQDDYPVDTKNEGGEKDAPYESSDDDETTEDESSTEDSTEDEKGSEDSTDDEGDEEDSADAQQAQIDTPLDFAPDVTVSDDGNTAFDEDTAFADDHTAFDEEETSSVLPSVSVSLDQPPESFSVFDSLVQVYTARCRLPPLSMIPLPQLREYPELVLRGTAHNIEKEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5T7</accession>
    <name>A0A401G5T7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0103890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608427.1">
        <property type="nucleotide sequence ID" value="XM_027752626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5T7"/>
    <dbReference type="FunCoup" id="A0A401G5T7">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5T7"/>
    <dbReference type="GeneID" id="38774431"/>
    <dbReference type="InParanoid" id="A0A401G5T7"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="295"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="561"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1239" mass="138288" checksum="D49A2755A8DF44D9" modified="2019-05-08" version="1">MLNEKYRGVIEQILSPTPANAQDLLKELGFSGLPTQEQVHREIEQKLLLPKERLPDHWLPTYQIHWDHPVSIPSLLKLEPSPPPTTLAFVRTGLQGRVTGYTEVSNPRVTTGLTSTSLDRAPGPSSNFVRGKSGYVPFWPGGLEEIRKDPVSLSDLHEDSRGLRTVAPGLTRGLHLPGDDAEESALADLERASQGGGKIGHGEDDEVPLYLNGDAISGPSVVNGVSEIDELLPTTRSQLSSIPASRRSHRRTNIQKRDWAHEVDINKPLTNFHELVPDMAHKYPFELDTFQKQAVYHLEMGHSVFVAAHTSAGKTVVAEYAIALAAKHMTRAIYTSPIKALSNQKYRDFKQTFSSSSVGILTGDVQINPEANCLIMTTEILRSMLYKGADLIRDVEFVIFDEVHYVNDAERGVVWEEVIIMLPDHVNIILLSATVPNTKEFADWVGRTKKKDIYVISTAKRPVPLEHYLYAGRELYKIVDADRNFVTQGYKDAGEALRRKQDKEREAAGLPPVQRLGARAAAPQRGQRGSASGRGSQRGGAPVRGGPPAGRGGSPRTFYQPDKNLYVHLLGHLRKKALLPVVVFTLSKKRCEENAGTLTNADLCTSVEKSEIHVAIEKALSRLKGTDRQLPQIRRMRDLLSRGIGVHHGGLLPIVKEVVELLFARGLVKVLFATETFAMGVNMPAKCVVFSGIRKHDGRSFRDILAGEYTQMAGRAGRRGLDLTGTVVIVANDNLPEQTTLLTMILGTPSKLQSQFRLTYNMILNLLRVEALRVEEMIKRSFSENRSQKLLPHQQRKMIESEKALSKREKLTCEVCSPDIESYYDTSFDIIEHNQMLLNMAAKHSQGLRLLGIGRVVILRDGHFRSNIAVMMKSAGVSDNVKVYYMLAMVDPDTKSGKHDVDAQSIPPRWPFTPASLAVDDATYELRPVPLTSVAMVCDCVIKVEVDLIVSGHRISSMQHAIGSLSMVLSDWIASGRIPEVDWSRIRSLDFQETLRSRNELAKRLPGYACILCEDFDDHYIVTHGEKVLLANIAELQRTLSDQNLELIPDYEQRIDVLKELKLIDENSTVLLKGRVACEINSVNELILTELILENTLAAYEPEEVVALLSAFVFQEKTDVEPVIPSKLEQGRDAIMAISDRVERIQDAHKIPGVEFRGLKFGLMEVVYEWAKGMPFEQITELTDVAEGTIVRVITRLDETCREVRDAARVIGDAELFKKMEECQIKIKRDIVFAASLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5W7</accession>
    <name>A0A401G5W7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608474.1">
        <property type="nucleotide sequence ID" value="XM_027752673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5W7"/>
    <dbReference type="STRING" id="139825.A0A401G5W7"/>
    <dbReference type="GeneID" id="38774478"/>
    <dbReference type="InParanoid" id="A0A401G5W7"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21093" checksum="603986B606F56D31" modified="2019-05-08" version="1">MPSNNSEALNASGLTAEETKSLKERTAQSHEEKIIQSIKELYTCKPSERTYEIYTSDAVFHDPIGIAEGIQSIRAQFNGLVKLFPRADIPSFRILENPPSLSKSTVLIDQDVAYYRDPNAKSPTKVVNSLLTLQTNDEHKVTRHTEEWDHKRETTRDDGFLGMLNEQRKKITASVTGMFISQEPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G629</accession>
    <name>A0A401G629_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="5">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0105010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608534.1">
        <property type="nucleotide sequence ID" value="XM_027752733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G629"/>
    <dbReference type="STRING" id="139825.A0A401G629"/>
    <dbReference type="GeneID" id="38774538"/>
    <dbReference type="InParanoid" id="A0A401G629"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="17">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="16">
        <location>
            <begin position="290"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1043"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1043"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE77621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1092" mass="122013" checksum="D5544FC6B6D62E3E" modified="2019-05-08" version="1">MIAEVLLVLAGHSSSLFPTDHTIHPAFSPLLHPGEEQCLESLGQIAVRYRKIKKACSTLGRTPSRYVSALYATLNQILKDEYENLVVETEAKVLKRDTSLVASGSFVPLSSIRATFAEWDAPLAALENLIDELELQSNWQPGPLIDLLLTRSHTGIHRVASIHARLCEAVQHVWISQLQAFLIHGSLSDKDPLASKDFVLLEGSVPSCLSAQSQESISYVGRAIGTVKAAKWENQFPRSLALDHTKMLESVLPQDQYAFDRVIADIRTTVSEWLWLNVLTHKDVEVAVESLASYFLLRNGEFALSLIREIERLKISRLTGRSGPTTMIREQDLHLALLRASLGTTAQHDPSLSYLRFRLPSGPLRPLLPSLATAPTKDLSSSLNPSSEPTTFDDLLLGTPLLLTYSVSWPLDLFLHPSDLHIYAILFAYLSALRKTHTRIHACWTSLSNSQRARRRWTGLGEGGTVEDLEARKLLLRCGWGVVREMSWFLDTLLGYVMTDVVDVEFRKLKSLLLEKTPGLIRQPTGTQSVSGTDIGISQMAHAHLQSNSTLPASHSNTSSAPPSRLDFSTLRNIHTTYLERLLTGSLLSNPALTAIIRMILEVCERFVAQVERWGGDVLPALLFEGSLAGGGDKVGEMVKERQTMVAEINETLHTLLESFYEQLSLSTTQQPFSAAADASKSMLYNASMATTSGFHTFIRTKRGRRLAGDEEVRRHVERLLLRLDFNGVFSNIKHQLPGTINCFTEHVATIRSSTKLLFINSSWQRMSAVALRRLSHHARLFSTTIMTSQYTPRLIGAPNTLEHRVYLEQNGNVISPFHDIPLFADQNNGILNMIVEIPRWTNAKMEISKEEAFNPIKQDIKKGRLRYVRNCFPHHGYIWNYGAFPQTWEDPTQTHAETKANGDNDPLDVCEIGEQVGYVGQVKQVKVLGIMALLDEGETDWKVLVVDVLDPLASKLNDIEDVERHLPGLVRATNEWFRIYKIPDGKPENQFAFSGEAKNKKYATEIIHECHEAWRRLIAGESPAKTPSYDISIRNVSVQNSPGLVSKNDPTYTSVPADSRKPPAPIEASISKWFYISSAQLPDDSARTSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Z9</accession>
    <name>A0A401G6Z9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0108330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608864.1">
        <property type="nucleotide sequence ID" value="XM_027753063.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6Z9"/>
    <dbReference type="GeneID" id="38774868"/>
    <dbReference type="InParanoid" id="A0A401G6Z9"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="3">
        <location>
            <begin position="525"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1114"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1306"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="867"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1258"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1344" mass="145927" checksum="96C949D687A14BA5" modified="2019-05-08" version="1">MHARTRANAPVQPLAVSATPLIGERILKSRWSEEETPRSLLPSSLARRPTQKSNLSLKSASSLSKRDQGPSSPRPNAARTPRPIPAPDPIITISAASNLGTNNNHDSAGNHHPLAPSTTGESTSYHSVLDDSHDELDYVTVEHPGPADSAIVSRPDKASRVLGIRHRKEMEPIPASNRTSIASARSAPAISVSAPPPSSSGPTMPLASLYVVSGLPKSPYTWTLADPDSVLGLHHSDGAVGRWWRPEVLGSTVSPGAGGGRRKKKGKTEESTSVFSSSGHLSKQEVGKMLSKALKLSFTREIEIIASTLQPASTVHTFTFTLPAPSTPLAPCASTDLLRASVLSGNSDPHSSIVTFPYPYTDDPFARARPSSAYLGPHFLSPHSQSAGTRDLALGAGGVKAGANNTVTYHGVCLTVWSHADAERTTAIRRTLEAGRSRKESAQSLVAARMKQHGTADPAAQARRRARMSARGPWGGPGTDAETDGDGETDGEGGAVSESDFEVASTVGHTPGESTLFLPGDTVFWLPYALTLVSRYPIYDLMRDYLTLSWARFSKDVQSHTLQISKILSHPAPRPGELVRLDASSAPIPLSLAGGPHGHTETSLEVVARFPGGLDFGRGLVDVNFTMWPLFKCLNIDNILTICEIALAPTGRILFFSRHSAILGIAVLTIKYLVELRGWNGVALSSVHSRDAKIYIDDPGPWIMGLATEVRYCVRAPAEVCVVDLDINYLNCPAPPPGVVSTKQQRDKYRQRLLAAFEPHYHPDHGVPSEFKEAFPAGRFRPVCKIQAKRGAASTAVADMVKPPEWWHSTRIIQAFDSVLAERMKKPSLLKRISSFGSVRPLPRLTVAEQHIQLSIRKRATAFVDARDDLETKIGRLSRRLNFLMTESDLWRDKFVTFEQYAEKLSVEANDLRTKINKEQRETKRLSSMVTMTAAEKAKLQSQLKDTETAHKGALEELEMMRQTMEKMEEERAEMIAEVEAQIESALASMAVDMDESDYGSRPSSRLSSRSAPSTYRRPTESRSRGLRSFGTESTLVDSYEGDERDEHAKTPLSTGTVMEVDEEQEEAPPKKKRFSASHGELPQDGMTAVDEGISQKSDKIAQKVLQIQRKLESALERRSLESQVSESDLSETPRALRSRLAKGGRASSRTSGKSRNFTASAPGTGHHSPSTQSFATRVPERPTSPTRDDVQSDHVQTDSPPTESWTKQDVRLSGLRKIPSTVSLSATRPKSPSMVTPTTPSLSVGAGVSTDDEDTDFQSAYSTSPRASYGSFDSYSSGAFHTSDTEHGSPISIKDQSYIQPIIKSRERVSSTATATASKIRKGSRASEDTVITAAPPTANINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7W0</accession>
    <name>A0A401G7W0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0111160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609146.1">
        <property type="nucleotide sequence ID" value="XM_027753345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7W0"/>
    <dbReference type="FunCoup" id="A0A401G7W0">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="GeneID" id="38775150"/>
    <dbReference type="InParanoid" id="A0A401G7W0"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="60"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="441" mass="49763" checksum="D8C096236517DB05" modified="2019-05-08" version="1">MSQGFHPTPEQLALAERRRLKREQRKATEAKEKEEQSRILSREWVTLQDSTRCQHTVRVMSWNLLAQCLVRRELFPTSDCLKANQRENMLYREILSHNAHICCLQEVDRTEKLLPILENAGYASVYASGPRKRHGCLIAYRKDMYIHAGEHIVHYDEQDVRDEGSEKAHIGSSFRTRNIASLVALKQRETQNEGVIVATSHLFWHPSYAYERARQAAVLLREVVRFRDEGVGNPQWPCIIAGDFNFQPDDPVYSLLVGDPLLPNQAARLDTSRVVHASIDPDVAITSPSPAAEDEEGEEAGGGDPDRVIVNARLATPEDGLLTNAELVHFFERLRSLRSVYDEGQRLQPQLSQMGLTFGSRVSIPDARHGAFEPVWTSYTHYWKAVLDYIFVLDPPSHKLLICSLAKPHSANDLGLGLPRRGIGGSDHISLGAELGWIVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7X9</accession>
    <name>A0A401G7X9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-ketoacyl-CoA thiolase B, peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0111740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609203.1">
        <property type="nucleotide sequence ID" value="XM_027753402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7X9"/>
    <dbReference type="STRING" id="139825.A0A401G7X9"/>
    <dbReference type="GeneID" id="38775207"/>
    <dbReference type="InParanoid" id="A0A401G7X9"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="287"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="412" mass="43861" checksum="C76BB7C487DC2CA0" modified="2019-05-08" version="1">MFSRLVPRTSVSRARSISTQSRGLAAILEKKPDDVVITFAKRTAMGRAKKGQLKDTPVDELLHALFKAALNETKLDPAKVEDICVGTCHPPSPLYVSRAAAMAAGIPADVPISTVNRLCSSGLQAIRGIAHAIESREITLGMAVGVESMSLNPRPTPEIVDQVGSHPQAIDCVQPMGWTSEMVAEAYDVPREKQDQYALISHTRAEKASAQGIFADEIVPIELRGTVISVDDTLRRGTTLEGLAKLKPAFPDWGSSFTTAGNAAGLGDGAALCILTTRERAEKEGMQVVGKYVASSFVGVEPRYMGIGPIAAVPKILAKTGLTKEDVDVWEINEAFASQFAYCVEQLQIPIEKINPNGGSIALTHPLGMTGTRQVVTGLAELRRRGGKVLCTSMCIGSGMGGAGIFVNELRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Z0</accession>
    <name>A0A401G7Z0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0111570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609187.1">
        <property type="nucleotide sequence ID" value="XM_027753386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Z0"/>
    <dbReference type="FunCoup" id="A0A401G7Z0">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7Z0"/>
    <dbReference type="GeneID" id="38775191"/>
    <dbReference type="InParanoid" id="A0A401G7Z0"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="50"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="425" mass="46461" checksum="0011AEAD0E8B0D70" modified="2019-05-08" version="1">MQAVARPLARAAPNNLRRAAALSTWSTVPAGPPDPILGVTEAFKADKDPRKINLGVGAYRDGDGKPYVLSCVRKAEQFLAAQNPDKEYLPITGLATFTKAAAKLAYGADSAPLKADSVAVTQSISGTGALRIGGAFLARFYPHAKTIYLPFPSWGNHIAVFRDSGLEVKTYRYFDRKTVGLDFEGMKEDLKNAPANSIVLLHACAHNPTGVDPTPEQWKELSNIVKEKSLFPFFDMAYQGFASGSTTHDAFAVRHFVSEGHQVALSQSFAKNMGLYGERVGAFSLTTADAEERARVESQLKIVIRPMYSNPPLHGARIASTILNQAELYGEWETEVKSMAERIISMRHKLYDNLVSLNTPGEWSHIKSQIGMFSFTGLTTPQTKELAEKAHIYMTADGRISMAGLNGHNVDYFSENVSKAVKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8L5</accession>
    <name>A0A401G8L5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 5 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0113780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609402.1">
        <property type="nucleotide sequence ID" value="XM_027753601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8L5"/>
    <dbReference type="STRING" id="139825.A0A401G8L5"/>
    <dbReference type="GeneID" id="38775406"/>
    <dbReference type="InParanoid" id="A0A401G8L5"/>
    <dbReference type="OrthoDB" id="428177at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15722" checksum="D49DA3C585B350E8" modified="2019-05-08" version="1">MESIQSYVQQAQAAGKKLIMEEWGSCYYDTLNSNCPVGDPLPTATRNANIAGWASNITAAGLPWLYWEVLPDADPHEGDDFEIGLVDPSWPTLKQAALAAPRAPAAFDFSEYLFDLGLDGFLCRCDSELRKSTQPLLCTTSDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8T1</accession>
    <name>A0A401G8T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPALPP motifs-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0114640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609488.1">
        <property type="nucleotide sequence ID" value="XM_027753687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8T1"/>
    <dbReference type="GeneID" id="38775492"/>
    <dbReference type="InParanoid" id="A0A401G8T1"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="100"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="28949" checksum="8D4EDAC2DE908AAA" modified="2019-05-08" version="1">MPTLPPDLLAARNSAPASSIERHKPVVGPSFPPSLARSLSRQEEEDDDDEYGPVPLPSGVTVEERDGVKEFLEKEERRRKQTEAASVPKAPQREEWMLVPPSSSDLLGSIDPSKLNRPRRFARSAAPARDVDSSLWTETPAERQQRVADEVAGKRRRAADVDAVDVEGEGEMKKRRKHEEEVRRGVEEHTRNIRGGTLLKQHASALKDEKGEDEPSGIWDHSRDMALSGRLMDDGSRQKFIRDARGLGDRFGTGKSGGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G982</accession>
    <name>A0A401G982_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase 9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0116210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609643.1">
        <property type="nucleotide sequence ID" value="XM_027753842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G982"/>
    <dbReference type="FunCoup" id="A0A401G982">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="GeneID" id="38775647"/>
    <dbReference type="InParanoid" id="A0A401G982"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="188" mass="20736" checksum="1C35BCE8FE1A9B93" modified="2019-05-08" version="1">MTSAELRAQTASEPLTLDEEYEMQRKWQLDEDKLTFIILSGEALNPAAQLTSEILTKLPMIGDVNLFLKGLPHEEEFEAEVEVMIAEPAFRCRGLASAAVQLMLSYATSANVEARHHPLPVPQEKLVARIGEANTPSIRLFEKLGFAVTKRVAVFEEVELRFGGRATGWRTGQVRMLGGHGCALVDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9V8</accession>
    <name>A0A401G9V8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0201490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609865.1">
        <property type="nucleotide sequence ID" value="XM_027754064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9V8"/>
    <dbReference type="STRING" id="139825.A0A401G9V8"/>
    <dbReference type="GeneID" id="38775869"/>
    <dbReference type="InParanoid" id="A0A401G9V8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18899" checksum="ABE96AC07EF5D931" modified="2019-05-08" version="1">MLAPVIRLLVRYIKRWRFFLVDCEALKSLQVVIPLLRQHAPALEEMTVAASNISCRLPHTQMAFFPFTFSAVNLRSLSLYNAPCVSEVHNIASAFPSLEELVLHGWAMPMDMDCRSFMQQVQPLQHLRSIEIWDPDDDLVESVPLPADSAFLHFPSLEELHLEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAI0</accession>
    <name>A0A401GAI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0203560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610072.1">
        <property type="nucleotide sequence ID" value="XM_027754271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAI0"/>
    <dbReference type="STRING" id="139825.A0A401GAI0"/>
    <dbReference type="GeneID" id="38776076"/>
    <dbReference type="InParanoid" id="A0A401GAI0"/>
    <dbReference type="OrthoDB" id="2755871at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="46183" checksum="4FC7EC1CBA4CFF2D" modified="2019-05-08" version="1">MLPEELWMDIFDFLQDDLSTLRACNLTCRAWVPLVRRHLFHSFAVRNNTDFAHLKSLVKTGLTPFIRNITIDAAAGAHMKFLEKPLPQLLQRLSAVDKLHLTFPAGRHMSCIRAETVQSILASFPANTVNVDGWFWRPSLQIQVLPCCFVTVHKARDRMYKLPSSPYMPSGSDHRADSEIQISELRLAGSTCAGIIQAGAVAHFLRPPFKVNVRRLEWNSRGSEACQDQLASILQRADTLQFCHIALFPSIGLKDTNYIPRAMDGVRFAHLESLHLQFNMYWLGPMYAWALHILSRVHSPHLGELKITFQGHPSTRSIPDPEMLDWGVFDAEVARIHAEVPQLFVLFMLKVSKRCMALWVRWVTEVITTRLPRARASRVRVGLAYPESHDSASTGAGEDSMIVQWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBI2</accession>
    <name>A0A401GBI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0207190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610432.1">
        <property type="nucleotide sequence ID" value="XM_027754631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBI2"/>
    <dbReference type="STRING" id="139825.A0A401GBI2"/>
    <dbReference type="GeneID" id="38776436"/>
    <dbReference type="InParanoid" id="A0A401GBI2"/>
    <dbReference type="OrthoDB" id="3070852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12833" checksum="10A97145DC6932C6" modified="2019-05-08" version="1">MSNDSASEPPSSVVSFSSYADLHTSASSSTSCSSVDFGYNLFTSYGLLLGSGNQVWHPPMLPPDQSPRFIHPPMLPPDQSPCFIHPPMLLPDESSGMFLHPPMLHQDDTDTIRAQLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBM6</accession>
    <name>A0A401GBM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0207780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610491.1">
        <property type="nucleotide sequence ID" value="XM_027754690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBM6"/>
    <dbReference type="FunCoup" id="A0A401GBM6">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBM6"/>
    <dbReference type="GeneID" id="38776495"/>
    <dbReference type="InParanoid" id="A0A401GBM6"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF60">
        <property type="entry name" value="LYSOPHOSPHATIDIC ACID:OLEOYL-COA ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42196" checksum="A8356933D88604EC" modified="2019-05-08" version="1">MEKFSAFRDPGTGIQPFLKPVPPLGSETLAYLALPFGYVVGAIRLSLIVVLGLLYALVVRGFCPVLIVVPPLYRLVTQFLTALICRLVLLLIGLWWIPVDVVARKRGRSQKLSEDWNPQAGDIIVSNWVSFVEILWLAFRFNPVFVLPIRSSADTTSPASESLASPVRTPGRRTGTGSAALSLPSARAPSPRVPIRGFRRASLLSMLRATGHVPISAQPGTAELEKLLSMEEIRNKADRPVVVFPECTTSNGRGLLRFAEIFREVKVPVTKFNVFVMCVRYDPPTALQPTLTHSIPSTVINPLPHLLTLAMSLAPLTVSIRLLAPSESPSSRAFLASEYVTGEQPVDLLSEACTSLIAHTGKMKRLGMGWEDKVAFLDFYNGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBS3</accession>
    <name>A0A401GBS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0208090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610522.1">
        <property type="nucleotide sequence ID" value="XM_027754721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBS3"/>
    <dbReference type="GeneID" id="38776526"/>
    <dbReference type="InParanoid" id="A0A401GBS3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="8520" checksum="3382DCB0C604DFF3" modified="2019-05-08" version="1">MVKFDRWQKNPRQLKAPNLLAQDFQELIAVERRDELRNKETSEEWKQKHGEKKKEEMKDKKEVKMCFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC69</accession>
    <name>A0A401GC69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0209870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610699.1">
        <property type="nucleotide sequence ID" value="XM_027754898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC69"/>
    <dbReference type="FunCoup" id="A0A401GC69">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC69"/>
    <dbReference type="GeneID" id="38776703"/>
    <dbReference type="InParanoid" id="A0A401GC69"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF5">
        <property type="entry name" value="CHLOROHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="57"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="481" mass="52390" checksum="C758C05460817599" modified="2019-05-08" version="1">MSTSYLLKGGIIATFSSDNQPKSFKADVLVEGSIITQIAESINVGPHVEVINCEGKWITPGMVDTHRHVFAIVLRGDQCDWLLSEYLVKMSWTVQPALTAEEVRIGQLAGCLDALHSGVTTILDHFHAANTPEHAEASLEATIQSGARVVWCPARQSAPTQLFPNMEFGNEEETCKWQMEKLKEWGSKDGGKLTPDGRVTLGLAYDIVGAGPISMHQEALKFAREIPVQVITAHVAKGRRILTWRDGGLLGPDVLFSHCNVLFDHTDPDDEMWAAMKDNGCAIASTPCDELGMAQGNPVAMDAVNRGVKCGLGVDALSINGGDIFTQMRVALQFARGRAHEAIEKNGHCAPKYNHNNAADAFRLATLGGAEALNMEHLIGTIEVGKKADLVLYDAESTNLAAIADPFQGITFHATNADVDTVLVNGEVVKRDGKLTKNLWGPIARELKQKADAVRERLPKEKLDALWKQYYDTFGSPDLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCC6</accession>
    <name>A0A401GCC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0209740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610686.1">
        <property type="nucleotide sequence ID" value="XM_027754885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCC6"/>
    <dbReference type="STRING" id="139825.A0A401GCC6"/>
    <dbReference type="GeneID" id="38776690"/>
    <dbReference type="InParanoid" id="A0A401GCC6"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="474" mass="52570" checksum="DEEF95D6EFB87F91" modified="2019-05-08" version="1">MVPRLSMPRLIPRLLRNLETARARPPSTAPLHTPPRRKQQGHDVDSLPQLPSLSPEGRAQSIVLDSLEPIMTIARHKRHKALPPVVKIPQPRNKGDQPVLYVRGEPRRAMSTEERALWANPYLRMLSTPIRQCLLTKRVLPKAFLIRLAPKLLPPTRIGGNRAEILAPDGLEHPNFKSPRVGNGYHITCFKDAITMMVGKAGVHKRVGRNVTVHKYLQEQIAHMLRVRVLQEMHILSLSLQRGERGALDVPIIRRLTRAEWKGVKSSGAVPYANAVAVLVVPPVNTNPSTKKRPKPNMSTAPTPDFVDGSSKGSRSLPLCVMHPTSSDPLDALIAEDEDLPRLLPQSRVPLYNGITLCPDVSQRAALHTSLLHLLRLERVARFKQHALLHRMEEARAQASGSANEEPEKKPGQEDLLPGDEKGSHAFLLCSDESTLLRADVAPLAIALWRVRMFEGGGWDEKLLETSGGWASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCD3</accession>
    <name>A0A401GCD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0209840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610696.1">
        <property type="nucleotide sequence ID" value="XM_027754895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCD3"/>
    <dbReference type="FunCoup" id="A0A401GCD3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCD3"/>
    <dbReference type="GeneID" id="38776700"/>
    <dbReference type="InParanoid" id="A0A401GCD3"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF5">
        <property type="entry name" value="CHLOROHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="59"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="481" mass="52413" checksum="DFCF1F119F1CC349" modified="2019-05-08" version="1">MSTSYLLKGGIIATFSSDNQPKSFKADVLVEGSIITQIAESINVGPHVEVINCEGKWTTPGMVDTHRHVFAIVLRGDQCDWLLSEYLVKMSWTVQPALTAEEVRIGQLAGCLDALHSGVTTILDHFHAANTPEHAEASLEATIQSGARVVWCPARQSAPTQLFPNMEFGNEEETCKWQMEKLKEWGSKDGGKLTPDGRVTLGLAYDIVGTGPISMHQEALKFAREIPVQVITAHVVKGRRILTWRDGGLLGPDVLFSHCNVLFDHTDPDDEMWAAMKDNGCAIASTPCDELGMAHGNPVAMDAVNRGVKCGLGVDALSINGGDIFTQMRVALQFARGRAHEAIEKNGHCAPKYNHNNAADAFRLATLGGAEALNMEHLIGTIEIGKKADLVLYDAESTNLAAIADPFQGITFHATNADVDTVLVNGEVVKRDGKLTKNPWGPIARELKQKADAVRERLPKEKLDALWKRYYDTFGSPGLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCM5</accession>
    <name>A0A401GCM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610842.1">
        <property type="nucleotide sequence ID" value="XM_027755041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCM5"/>
    <dbReference type="STRING" id="139825.A0A401GCM5"/>
    <dbReference type="GeneID" id="38776846"/>
    <dbReference type="InParanoid" id="A0A401GCM5"/>
    <dbReference type="OrthoDB" id="2804722at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="416" mass="45872" checksum="14B83FACB601DBEB" modified="2019-05-08" version="1">MLQQFYEIRDWNLQLRAENQKLFSDNRGMAKLIAGQNERLAQLRASPEHQSRIIIELQNQLRIMEANREVLVYDHHRALEEIVRLRNEVAHLGGKMGLQSVPIVSKSDLPALSRDGDLAENSIFMGSRHRNNSSVDLHIDTNGLPRPIPVPPEMSASISHPPLSHRASPYPRSLPRRQHTHDGTKSLPATPMVTIPPATTMPLGPFSAGPRAAANGSHLIPKQENVIDLTLDADDPMDGTSRKRRRVSEELPHVVRTAQPVTSQEPLPPPEQHAMDGIVATSASTVAPISDVAPDGTVPAGEVPPEVIAVGTALKETGSLEVTSDSVTTASQTNDVVSEERQILQECVEENFEEGEGEDEGRLFCGISRHFARGTEEPPQPFVDATLEELVAHCEHEHPRGWERLKDLVKQHQDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCZ2</accession>
    <name>A0A401GCZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0212220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610933.1">
        <property type="nucleotide sequence ID" value="XM_027755132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCZ2"/>
    <dbReference type="GeneID" id="38776937"/>
    <dbReference type="InParanoid" id="A0A401GCZ2"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="77"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="267" mass="29761" checksum="B8987453D3CD51B9" modified="2019-05-08" version="1">MQTSFANLEIRSNHGETSMSSPTSQSGLLDESHHGCPFSGASGNHADHTQPAGKPQATCPAIFTQEVDPILIKHSLEDRIAYLTDFLNFTSADSDVINKVAPHVNDVIPEVVDSMYAKLFEFDITKKVFMKRNQGFDGPLPKRLEDLTLDSPQIVFRKVFMRSWARRVLTSDYASGKTWAYMDKVGLMHTGASPFKHQRSLGITPLNVPYRDCALTLGLVQNILQTAILRLPADKATTEDKIAAVSAINKVIWIQNDLFSRHYIVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDC6</accession>
    <name>A0A401GDC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 19 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0213940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611097.1">
        <property type="nucleotide sequence ID" value="XM_027755296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDC6"/>
    <dbReference type="FunCoup" id="A0A401GDC6">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDC6"/>
    <dbReference type="GeneID" id="38777101"/>
    <dbReference type="InParanoid" id="A0A401GDC6"/>
    <dbReference type="OrthoDB" id="5554402at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019419">
        <property type="entry name" value="AIM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28177:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 19, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10315">
        <property type="entry name" value="Aim19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="132" mass="14244" checksum="21E54CF4849B6E9D" modified="2019-05-08" version="1">MPAEGKSKTCDSPYPAIEAVIRPYSQYPIPVWSLSALFLASSFVPPRPFFPPIMHRIGFGAIFAGAGYVLSTGDTRNGSGITTAWSLTYLFFNMRKSLTSNRSAVSLALTGATLASTALYGSEYFLLQTDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEJ4</accession>
    <name>A0A401GEJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0303140</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611512.1">
        <property type="nucleotide sequence ID" value="XM_027755711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEJ4"/>
    <dbReference type="FunCoup" id="A0A401GEJ4">
        <property type="interactions" value="593"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEJ4"/>
    <dbReference type="GeneID" id="38777516"/>
    <dbReference type="InParanoid" id="A0A401GEJ4"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE80599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="25302" checksum="7BAAC9C529BB2DF7" modified="2019-05-08" version="1">MSEPSPSSSSREDPKPKPVLLIVMGVAGTGKTTLAHALSELLRLPYVEGDALHPPANIAKMSAGHPLDDADREPWLARLRTTAERIVAQQQQQQQQAGLAPAVPSSDHCTSIAPPPAPSSSPPPPLRPGVLVTCSALKASYRSILRGTPRPPHGALPDAPAPALATYFVYIRGDRALLLERVARRRGHYMKANMVDSQLGALESPEGEEGVVVVDMTDATEVQVAKVLEAFEGVISPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEW1</accession>
    <name>A0A401GEW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0304530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611647.1">
        <property type="nucleotide sequence ID" value="XM_027755846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEW1"/>
    <dbReference type="GeneID" id="38777651"/>
    <dbReference type="InParanoid" id="A0A401GEW1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="6035" checksum="07F134D04FED1B16" modified="2019-05-08" version="1">MSSVIPSPALPLEVLEHITDWIGKWPTHVYNMERNEFVWSESEMRHSWPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF60</accession>
    <name>A0A401GF60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0305470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611740.1">
        <property type="nucleotide sequence ID" value="XM_027755939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF60"/>
    <dbReference type="STRING" id="139825.A0A401GF60"/>
    <dbReference type="GeneID" id="38777744"/>
    <dbReference type="InParanoid" id="A0A401GF60"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="217"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="252" mass="26920" checksum="A52FDC246E49A1C9" modified="2019-05-08" version="1">MSYGPGRGYGGGGYAPPPGGPPAGYAPPSGAPPPGAPPAYGGGYGGGYGGAPASGYGRYGGEPGGFAPAMTAGPPAGADPQLWSWFTAVDTDRSGQISPHELQKALINGDWTPFDLDTVKLLMTIFDTDRSGSVGYNEFAGLWKYIKDWQHVFKHFDRDRSGSIDKRELQDALRQFGYNLSPPLLGLVERKYDVKAGSGAGGRDDGITFDRFVRACVVIKQLTEAFQKLDADRDGWIQINYDQFMQTVLSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGP1</accession>
    <name>A0A401GGP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612245.1">
        <property type="nucleotide sequence ID" value="XM_027756444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGP1"/>
    <dbReference type="GeneID" id="38778249"/>
    <dbReference type="InParanoid" id="A0A401GGP1"/>
    <dbReference type="OrthoDB" id="2755612at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="281" mass="30666" checksum="3A8B70320AB93227" modified="2019-05-08" version="1">MDCSERPYSCLENVTPFNSASGSCSDQHTFNHTSSRNRASYPEVCAPHAEVPIRGHSAPNTSISRTSSSLSTASSTRVFRPLPTPPYSANIHSPESGWHSDASDRLAPPSSFRPPPRPLPRPSGPPAVELPAVELAWASTTLSPCDLPSCPTSKPVLSVSIPQSRLVDEMRVIESPPSVPNPPHDVSAACPSNRSVIPVHPDSEFDDDSDLVLLEDTDLSSSFERCSAEEKTLPPLPAEAQSARHPESPVKRKWVVEKNGKRWTQDSHHYAQVLHVLRKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHN9</accession>
    <name>A0A401GHN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0400390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612581.1">
        <property type="nucleotide sequence ID" value="XM_027756780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHN9"/>
    <dbReference type="GeneID" id="38778585"/>
    <dbReference type="InParanoid" id="A0A401GHN9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="64" mass="6596" checksum="7CB7B0F37C699042" modified="2019-05-08" version="1">MRLFAAPSSLRKGLGNELQWEKDVGDGAQCDTASIAGVAAQPLSSNEHLQGGSAFNNSLPATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHT2</accession>
    <name>A0A401GHT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0400540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612596.1">
        <property type="nucleotide sequence ID" value="XM_027756795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHT2"/>
    <dbReference type="STRING" id="139825.A0A401GHT2"/>
    <dbReference type="GeneID" id="38778600"/>
    <dbReference type="InParanoid" id="A0A401GHT2"/>
    <dbReference type="OrthoDB" id="194289at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="355" mass="37478" checksum="722949FE6CC856BC" modified="2019-05-08" version="1">MGRWHSPRYLSSPCVSLPPLRRAPLAFRSTLSFTTPSRALFTSVRSSESLTANVYPAASTLIRGQVFARGVASAVSGRPGSQSLGQAALNVREELGNSTSDLAKVIAGANVYADSVIPTQKTFVGITGAVAQTVPTPFMVLGLAGGLPYLGLSSATIYLAYQAGLAVTGGIGSMDPGVAITMLHQALDFQVTYGAVLLSFVGALHWGMEFSGYGGHKGYARLLLGAAPVVFGWSTLALPPMEALIAQWVGYTAVWWADSKATAAGWAPRWFSQYRFYLSILVGTCIISSLAATSYWGPVGGHGLISHDLNMVRAERKQKQPEADGSVRGNVEALLADESGDSYVIIKKKRGEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHV1</accession>
    <name>A0A401GHV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0401430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612683.1">
        <property type="nucleotide sequence ID" value="XM_027756882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHV1"/>
    <dbReference type="FunCoup" id="A0A401GHV1">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHV1"/>
    <dbReference type="GeneID" id="38778687"/>
    <dbReference type="InParanoid" id="A0A401GHV1"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE81770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="371" mass="40979" checksum="51B95CAD7933F2DF" modified="2019-05-08" version="1">MAPEVYIPAQRAVETLVAKLRRRRVVGSRQAALETVLVLREVVSKARFSNFDQLVALIREVGRRLSEAQPKEHTVGNIVRKVLHNIREEYNTATRGDVASASTKNVFTISKFVLQGQPRKHNVAPKSETTTFLRENDPNDPDSFAKGLKPVLIEAIKEVLDELETVYDNVSKNAKDHIHSDEIILTIGHSHTVEAFLKSAKHYRNYTVIVAETGPSYNGHEMARSLSAAGISTFLVPDSSIYAIMSRVNKVILGAHAILANGGMFAITGTLLAATAARAHSTPVVVCAGQFKLTPLWNLYHDYGALDFADPSSVLGFEEGNLVDKVDVLNPYYDYVGPDLVDVFITNDGDHPPSSVYRLVKETYDDDDHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHZ0</accession>
    <name>A0A401GHZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0401830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612723.1">
        <property type="nucleotide sequence ID" value="XM_027756922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHZ0"/>
    <dbReference type="STRING" id="139825.A0A401GHZ0"/>
    <dbReference type="GeneID" id="38778727"/>
    <dbReference type="InParanoid" id="A0A401GHZ0"/>
    <dbReference type="OrthoDB" id="3258136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="240" mass="27070" checksum="C3006C24EF0F95F4" modified="2019-05-08" version="1">MLYKLTSTDKGQTTLIDCATGTVAFRISTPRPARARASTLDSLKRTMSRNCSQETVPRTDRPTTLVEDKDGAIVAEIDWAPGNYATLIRIGEEVLRGVAELFDCAFFKLYNDETQLPMRTENTWCITPTSLTLVDDDGEVIGKFHAKCVVVNGQPLRSRRGGYDYFELDGIPQDEVLEIILCLLFVRPLYERVHRSSRSKRTRLVAGLRRRAIHSFAGLRKSLATSRCEGTNARIIRRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIA2</accession>
    <name>A0A401GIA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0402620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612801.1">
        <property type="nucleotide sequence ID" value="XM_027757000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIA2"/>
    <dbReference type="FunCoup" id="A0A401GIA2">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIA2"/>
    <dbReference type="GeneID" id="38778805"/>
    <dbReference type="InParanoid" id="A0A401GIA2"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="27"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE81888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="663" mass="72903" checksum="6D72AB6BD1F61133" modified="2019-05-08" version="1">MSLDKQVALARTLNIDSTNLNKATRLIVAPFLQKLYEIVNDPKTDELIRWSDDGDSFYVLNHERFAREVLGHWFKHQKFTSFVRQLNMYGFHKIPHLQQGVLRSDTDTEAWHFEHPNFRRGQPDLLTFITRKTKSTHGNVDEAQLDYNETVNVAPQVGTLSAGQVLDINSVVHGIQAIKRHQQAISADLNALKQSNDLLWKEAEITRQRHDKHQDTINRILKFLAGVFGNSADPKDGSRSPSAVVPVARQRLMISDGRPKGKAADVGEDDRGSVQTPQSDHDARHLFPIDQIAAIDEQSQSIASSAAFSPVSLDSPATYISHTSIRPDMLSRSPTASGPNSGSNSSNLTSTEVPTPDGCPQPQESTLSPSALTSFTPPPSQSDGLWQAAIQQMLNSPDQMQRLMQMLASQQNHPMRGPSSPSTGYYGLSSQVMQYDPNQNDYSRYRPDIPPAPHPSLPLLGPQLQNDAPSLGPLLDDAQRLQRTYRDAAEIEADMDVLQTSLNSLIQNLGIDPHSIVPQAHDQDELLHNDEPPHNNVASTSTGIPMDRPTLSGLEPHDDPSSDLFLDALLSGINAGGGEYPDVTGRYDPSTEIDGTKVGDASTEQLTAFLDEVSDTASPLPPHSPDSKPTNGGYKRKLDMADLSIPQQKADISMTVPKVKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIK7</accession>
    <name>A0A401GIK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0403390</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612876.1">
        <property type="nucleotide sequence ID" value="XM_027757075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIK7"/>
    <dbReference type="STRING" id="139825.A0A401GIK7"/>
    <dbReference type="GeneID" id="38778880"/>
    <dbReference type="InParanoid" id="A0A401GIK7"/>
    <dbReference type="OrthoDB" id="2801734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="41"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="284"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE81963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="549" mass="61000" checksum="BF5BD6759DCF7666" modified="2019-05-08" version="1">MIREKLVTGLMLNSKQQPDLICEPCLAGKMHANPFPTSDSHASKPLELIHTDVHGPLPVRTHSGYRYWTTFIDDYSQFRVVLLLKAKSEAFDAFKQYKAYAENLLEAKIKAVQDDKGGEYMSNAFIQFTQEAGIERRHTTRNRPQQNGVAERANCTMDNDITAMLAESKLPPSFWGECIASMVHVWNRLPTAVVKGATPYELWHKRKPDVSHLRVWGCTAYVHVQKDQHTGLGPHMQKCVFIGYPAGYKGWKFYNPDTKKTIISERADFDERYFAGLKCTPDIPPPSPMSFPPADIIPPPVAPVPGQDLGGDDAHVPNPVPCPVTPEADPPAPPPAPEHPVTPPPPDPPVHHRVPTPPPFEPIDHRPIAQHRVPCNVRPTWKMRASPPPVQNAESEDELDVIDADAGFVEVQFAGLSAGADPWTYKQAMGSPDADKWQQAANEEIVSLMANNTWEIVPLPPGKKAIGSGWVFKVKHNADGSVERYKGRLVAKGYSQRPGFDYTEVFAPTFRQSALRLILALAAAEDLELRSVDISSAFLNGDLEEEIYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIT0</accession>
    <name>A0A401GIT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0404660</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613000.1">
        <property type="nucleotide sequence ID" value="XM_027757199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIT0"/>
    <dbReference type="STRING" id="139825.A0A401GIT0"/>
    <dbReference type="GeneID" id="38779004"/>
    <dbReference type="InParanoid" id="A0A401GIT0"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cwc2/Slt11"/>
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    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
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    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
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    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
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    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
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    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="17">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="595"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE82087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114687" checksum="6C882D714DEC26D5" modified="2019-05-08" version="1">MATAVMTNGNASSGDWHDRYFHVDQILDRPGPRTDPSFLAGDGVKDFLRNQCKILVIGAGGLGCEILANLALSGFKDIHVIDMDTIDISNLNRQFLFRPKDVGKPKAIVAAEFIMQRVPGVKVTPYYGKIQDKDDDYYMQFNLVICGLDSVEARRWINATLVNLVDPENPESLKPLIDGGTEGKYICDKKLDTDDPEHIGWLYSVASARAKEFKIEGVTWSLTQGVVKNIIPAIASTNAIIAASCCNEAFKIATSSAAYLNNYFMLIGTDGIYSYTFEHWKRDDCPVCGGEALDISVGKEWTVDRLIEMLVEKQDIQIKKPSLSTVARQIYFQAPPQLEEATRPNLEKKVSELVEDGGDIIVTSSTLPFNLTLRADINKAGWEQSEFPILCETCLGDNAFVRMSKQEYGRSCGTCARPFTVFRWNPGTAMRFKTTVICQTCAKIKNVCQTCLLDLEYGLPTQVRDTALALQNEAPTSEINREYYAQNMDGKMEGSRSLLDSGRASSAGKEMLKQLARTDPYYKRNRPHLCSFYAKGECVRGAECPYRHEMPVDNELSKQNIQDRYHGHNDPVARKIMTSHAEAMGLQPPEDQSIMSIFLTSLPATATEQSIRTRVVQSLPGVQPSQLKSVVHVAKSRCAFVNFKDRASAELAAQAWANGLEMEGEILGVKWGRTLTALRLLSDTCTAAIDGLQPSPTVSPSQASAPSSDVLRKDFVSLLSLVYTSTTKLTLAFRQPEPAYSAAVAPIRDLAAYIAALTTCTSLFDAHGATLSAEVRLAAREVCESVRWLARTLGGDADAGEDNLVRTGEVHDLVDRARRELSANNLAAVRKRWVQDRAILDDTLCEVAEMVETAAVEGDGEDDEFDDGEWDELGLGSSKKMSEVELDRTKKIQPLLRFSTLLHKRVLLDILPTAPPPRTDPTSYNADLDSLPSHSHALVLASEELVAVLYAPQDIFAVTSAISAHGDVVRQLRAVLVDKALLPAPADEVEALAEGVGVMSVTRSAIKGKKDVRKWFDTCFAQIEKLSTNIIDAIALERSNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKB2</accession>
    <name>A0A401GKB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0409930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613521.1">
        <property type="nucleotide sequence ID" value="XM_027757720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKB2"/>
    <dbReference type="STRING" id="139825.A0A401GKB2"/>
    <dbReference type="GeneID" id="38779525"/>
    <dbReference type="InParanoid" id="A0A401GKB2"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="11">
        <location>
            <begin position="663"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="851"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE82608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="913" mass="99475" checksum="8B8B662BAE26672A" modified="2019-05-08" version="1">MESITPIILASPTHLEQESKLGLAILICVGFTSPCATYSSPLRRRLSPLSRADVWTHRRLQSLFVSATYFIGSIPPRGLLRQHIPSRSSRQYLTKLPATTSVSRPQLEQPHPYKIQKRYSQTNATVQKPKPSAAMSTNAPAPSRQYLAPLSRHAVQKLPALACHPIDDFLSSDVDVDLELSFASTMSLNSPTRGLQELSAEDADYAPMDISPAPQRMLPPSVSDSSAGLKLNQGRARATTSASRLFGRDMSNGSGLLSGLTSSAKSVTGSGGKRLQRSALPVEWLASGTLGRDENVYGQDMLPSPATSDAMDVDSSFVHVRPRPVSRECPLTAAPTITTFNLDNNPLLSSPPASAAPTVTEFNGLYFRAASPLGDSDDVVLNELVDASHNSESPSQPFHKKRRSTSPQPEFIDEPQHIMDDEVLFESSPAASSPSARRLERMASMPLRKPMLSGLGAPLGLNTNKKRPRRPVLSAMLAPGDSPVDKPRSAYPIVDGVLDDEDVVQDHPHILPPVRRAISAMLPPSTLDESMASEIGESFDSEGPDMSSPAQAYAKRQHVKTIRRCDGTDDFRPLTGATALVRRDTEVIMTGLRRSEDRDSRPAENERDTPRSKYLHAGPGLGGFGDNEAYGKILPCQRVREDGLMRINPETLDALVDGAYNSKLASFHIIDCRFDYEYNGGHIPGAVNINTTAGVEEFLLGAGAIKPTPSTSGDLNKKVVLIFHCEFSVKRAPTFAKYLRSKDRALNNHVYPRIYYPEVYILEGGYCQYYQESGARCQPSGYVQMDDPLYAASRKEDLDHFRKGKFGRTKSYSYGEGKMTSLASQQPKRNTAPSGTNALFAAANAARTRRGGMGNAGLQMLPEDKSTGHQTEDEDTDIGDSPCPPPSKGVVFKGKKLNRLAKAESYGPSRMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL80</accession>
    <name>A0A401GL80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0413180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613844.1">
        <property type="nucleotide sequence ID" value="XM_027758043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL80"/>
    <dbReference type="GeneID" id="38779848"/>
    <dbReference type="InParanoid" id="A0A401GL80"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="53" mass="5814" checksum="30D4BE0D0236F060" modified="2019-05-08" version="1">MWTFVRSVDASIYLAPADIVHPFISKRLLGEGEDVGEDAQLRAEAVDGSSKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLA3</accession>
    <name>A0A401GLA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0413320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613858.1">
        <property type="nucleotide sequence ID" value="XM_027758057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLA3"/>
    <dbReference type="GeneID" id="38779862"/>
    <dbReference type="InParanoid" id="A0A401GLA3"/>
    <dbReference type="OrthoDB" id="3014913at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="583"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1114" mass="127182" checksum="836631F82C9883BE" modified="2019-05-08" version="1">MRTQSWPSTTRFPATKLAPATIDIGYFGASGPFGRLPSVYKTPNPLYEERVSGFNTHATGRMSVKEQRCELREEMHAKFVLMPVDEFMDDFVPNFDNPLGQQKPDFINAFKNMPGNDKREFELYRPLVDCVEDANLCPGHTLRLVQNKADPDDPSRQKVDAALFRTPDNVPADGRPHWALQNLSIEFKRHRNYDDPFEEKKRRPKRVHKATKVHDVEMAAPEPEQSEDLTYMTTTRRFVPGDSLTNVVENGPHDMSRFALLDNVWVLKKAALEDEFSEQEFLNRVPVFATGEDIFDEDVTHPASEPPSEASGVTDNESDFHTASEGDDDFDGGHKSFSEGITGLVGKDEPEVDGDVSRTYKHFYPSVAEMVDTQEDFFQTPPTSSRAEDNAKAIFKTAPEADARRRTAVRGQIISYAKMMFSRQHRCFVFTVLILGDCVRIIRWDHAGAIITHKFNYMTTQHLGEFLWRFSHMTDEQQGYDMSAVPVVPGSADYKLMSKMAMPMDPPDPSKGDYARRSFIKSLDLKASNEDGPDEWLCWKFTIVPEKWRQKGDVSADRPIAADANSDEDRAIPSSNMSEMPAARHFLVGKPHFESPGMTGRATRCYIAVDCEGEKFVFLKDVWRVDLEDIEMEGHILQTLNKEGVENIPTLECHGDVEGRYQQTVTHKYLKLVRPDDLNPVKKHAHYRLVVEEICRPLKDFRNSRELVKIIAECIDAHWQATDKAKYAHRDVSAGNLLMHEKMEEMDGEFHEVRTGMLCDWELSKRIEDEVDEQDNNLETDNATQKRTKPRQPDRTGTWQFMSVLLLDFPWKEVTIPDELEAFFNVLLFHIVRYTNSSIRDAGVFMSQYFDESIIDSLDVQYTCGSVKRNVIQTGVLKRRMEPIKFKDYNGLDHIPLNNIVNHLLRLFKAHYTVTLPDLLLQRHPTEDQRKPDRVDSEQETLNSSGSAAATDENTKKRSIQDMLAARAVAKLEERLAKHSKNSRKQKSLQSEDQALEQALEMEKAAATRLKTQEHVYSLLINAYADEKWPEHDKVDDRVPSNYSYADYRERGLKFPPAPSSSSGSESPSEARPTKRPRLPVQAASGVGRGWPSSSYARRRGKQPGRLNASTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLI9</accession>
    <name>A0A401GLI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0500650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613935.1">
        <property type="nucleotide sequence ID" value="XM_027758134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLI9"/>
    <dbReference type="GeneID" id="38779939"/>
    <dbReference type="InParanoid" id="A0A401GLI9"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052097">
        <property type="entry name" value="SET-MYND_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46165:SF2">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="45467" checksum="39E9D349BA0B8800" modified="2019-05-08" version="1">MPPLYSLEELTALADMNISDTEEEALKELGNDAFRVRDFRGAIKLYTLALQNLPDSPANLEARRILLANRGQTYHLFGDLYTALRDIDMALSPRYTRPDSPRILTTKCRFRRAKLLFTFARYDEAKVDFDTFVNLMDALDISLDDAETDLGKSIDTGVSAPKSGQRYKNEQLMRAIDARGLVLKPFNRLNFPRGSTDLLFGPPVSDEDPILTFYTRRGTEFPSDMTQASIAYPLSITAPYFKARPDQGDEPYLMHPEDPYPDDVQLSWFMDNLFKSAMVMFPSHLFSDAEHRRCVYGALDHDDPRHSVVMVHTARGRMLIVPRTATLKQIIEGSRWPRDDPLPFEDRRQQPRRRDDPIDGIELGRGGSIELYVIPNEKLSHHVEYHEKCFKFVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM61</accession>
    <name>A0A401GM61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0503200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614185.1">
        <property type="nucleotide sequence ID" value="XM_027758384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM61"/>
    <dbReference type="GeneID" id="38780189"/>
    <dbReference type="InParanoid" id="A0A401GM61"/>
    <dbReference type="OrthoDB" id="2803297at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="15383" checksum="CEC6D5D23E062912" modified="2019-05-08" version="1">MASVIHEAKTPFEVLQDEKKAAAKDSWDPFASREEWELAQWLMTAGLSQTAIDDYLKLPLVQEHANLSFHNKRAFYQKVDALPQGPSWSCELWEVTGNKLDEKGNTCIKTLELWKCDPVECVKELIGNPAFKDVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMI6</accession>
    <name>A0A401GMI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mug135-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0500070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0612 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613877.1">
        <property type="nucleotide sequence ID" value="XM_027758076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMI6"/>
    <dbReference type="STRING" id="139825.A0A401GMI6"/>
    <dbReference type="GeneID" id="38779881"/>
    <dbReference type="InParanoid" id="A0A401GMI6"/>
    <dbReference type="OrthoDB" id="2803487at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013902">
        <property type="entry name" value="Mug135-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08593">
        <property type="entry name" value="Mug135_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mug135-like C-terminal" evidence="2">
        <location>
            <begin position="193"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="283" mass="30344" checksum="1A1B8F5DD14C38B7" modified="2019-05-08" version="1">MGCPAMSAVVVLSFKSHPARATGSELNLELALNHASNHASTAMSVAAPQIPVPAGIARAENTGVIDSPPQPHNPPTPKDVALAVLFEHDTLAAYRSRTLTQDKFINVVQYKNAVVAAATENPAGPNNAQPPWFAQAMATALQPLEVRMTAFGNELQTVKANIVEMKADIATIKVDLKDVKDRQAHMQRAVALMHNRTVGPGNATPFLEVPWANGTFPWGYIHHNNPLPQLTSADVVHALGRRESRRYFEGYYPGQEVPDDLPARGAAILAAIGCAQEHADPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMY9</accession>
    <name>A0A401GMY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614486.1">
        <property type="nucleotide sequence ID" value="XM_027758685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMY9"/>
    <dbReference type="GeneID" id="38780490"/>
    <dbReference type="InParanoid" id="A0A401GMY9"/>
    <dbReference type="OrthoDB" id="3256283at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="28224" checksum="324AD307D65BAD1B" modified="2019-05-08" version="1">MPKTKGAKAKVGADTPKKKGKRTADETVDAPQAKPAKRAKATEESAKASASAPDKEAEIPEPKFSGNFDIYAATLPFLTKVCLPSGQTTPQYEELYKTILTYQAKPDSSGRCYLPAGATSAGKFECSQVEDPMSEEALDVEINFVTKEKKLSFTRAERGKFKTPGSSEEAPGISATTTLEGSHCGFDSAEGVFKMTRVWAKAMPTGEVQELFEGYFSLDVEYSWLYSSKGHGDGAEYEFGFWAVHARKNEEGEEIGLVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN35</accession>
    <name>A0A401GN35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0506780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614536.1">
        <property type="nucleotide sequence ID" value="XM_027758735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN35"/>
    <dbReference type="SMR" id="A0A401GN35"/>
    <dbReference type="STRING" id="139825.A0A401GN35"/>
    <dbReference type="GeneID" id="38780540"/>
    <dbReference type="InParanoid" id="A0A401GN35"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="336"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE83623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="469" mass="51328" checksum="3D3A153A04E31A03" modified="2019-05-08" version="1">MAPVKVTKICCIGAGYVGGPTCAVIALKCPHITVTIVDLNQARIDAWNSADFSIPIYEPGLVDVVKQARGRNLFFSTDVDKGIREADLIFVSVNTPTKKSGVGAGFAADLNYVESATRQIAAVANSNKIVVEKSTVPCRTAESMRTILEANSKPGTRFDILSNPEFLAEGTAVTDLLSPDRVLIGSLQTQEGKDACQSLTDVYANWVPKGRILRVGLWSSELTKLAANAMLAQRISSINALSAICEATGANIDEVAHAVGFDSRIGPKFLRASVGFGGSCFQKDILNLVYLSESLHLPQVAAYWRQVVEMNEYQKSRFSKTVVDTLFNTITNKHIALLGFAFKADTGDTRESPAISLVRDFLSERAYVTIYDPKVDEEQIWADLQEACPLMPLANIKKQVTLVHSALEACKNKEAVVIATEWKEFRDIDWESVYVHMAKPAFVFDGRLLVDAEKLRKIGFKVTVIGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GND8</accession>
    <name>A0A401GND8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0507340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614592.1">
        <property type="nucleotide sequence ID" value="XM_027758791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GND8"/>
    <dbReference type="STRING" id="139825.A0A401GND8"/>
    <dbReference type="GeneID" id="38780596"/>
    <dbReference type="InParanoid" id="A0A401GND8"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="140"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="576" mass="64296" checksum="DB6926AB96876EDD" modified="2019-05-08" version="1">MVARSLRSERSGIPVYWRPLIRTRYFSRTLFFFSQFHTPSLQHTMATSIANLEGDPRIVDKQEDGHDFLEPTHPHAKVTLEEYCAHADRQRKFEMEGPSTLSPSSSNIGEKNEKFPDISVEANLTEDEKERINARRALRTASWAAVFYLITTDILGPFNAPFAISQVGYVPGVILYFFMGAIACYTGLLLWWLFLKLDSDIFPVKTYSDIAERIFGKAAKHICTILQTIQLIINVGTICLSNGQSLSQMSKGRLCFAVCIVIWAIVGMLIGQIRTLKNFGWLANCAVWLNLLIIFTSMGFVAHSPPNYAAALSSLGVPEGPIVHATFVSAPLYNKVNGIMQMVFAYGGAMIFPEMLAEMRRPWDFWKGMCCAQLLIFAAYLMYGVFVYAYQGQFTLPLAYQGVSKYSWQTLNNTFGLITGIIAAGLYGNIGIKVAYYNIVEGMLHGPQLMSRTGRFIWTGMVLLYWALAFIVGAAIPQVATISALVAAVCIMQFTYSFPPALICGFYFLKDARGETGRMWWYRGLFSGYWWFKWFNLILSLASFSMAGLGMYGSGLAIKATFKLGAATSFGCTPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNU2</accession>
    <name>A0A401GNU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-mRNA-splicing factor spp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0508970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614753.1">
        <property type="nucleotide sequence ID" value="XM_027758952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNU2"/>
    <dbReference type="FunCoup" id="A0A401GNU2">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNU2"/>
    <dbReference type="GeneID" id="38780757"/>
    <dbReference type="InParanoid" id="A0A401GNU2"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="457" mass="51002" checksum="C6266524B2338777" modified="2019-05-08" version="1">MSSATTSKVSFTIRRPTPVSRDESSGGDSDSGFKVPHLPRHLVSGGSTPGSPLARSAPASPKHNSRKYTERDSSDEDEEIEDELVTGFDSFGVQRLHEKRKEPQGPLVIPALKNKDWRELARKRKALYVPPSAQAETGADGSVGGFGTRDAINSGAQLSGLQMKKRVKLEDEAMAVEEAHETQVVAKVENEVKEEETEDQKAIRLLLARARSDDATGLDGPAIEAIPPPSEDDAYRQDVVELPESASLEDYERIPVSQFGAALLRGMGWKEGTSASKKNKGLIEPWLPQARPALLGIGAKEREVFDDGSKGKKGRKGKPDKKYIPVVKRERQPGEGSGSGTGSGTSSRRRSPSPIRTSSRRASRSPSPERRRDRDRRDADYDRDKGRDSKDREPDLNRDRGGNRDRDRYLDKGERDRDRDMDRRRDDRRWEGDRRAESSGDRYDSDGRRRDKDRRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPT5</accession>
    <name>A0A401GPT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0601480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615083.1">
        <property type="nucleotide sequence ID" value="XM_027759282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPT5"/>
    <dbReference type="GeneID" id="38781087"/>
    <dbReference type="InParanoid" id="A0A401GPT5"/>
    <dbReference type="OrthoDB" id="3047760at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="238" mass="26174" checksum="96F7D2C7947FBB31" modified="2019-05-08" version="1">MAQAIYPTDILSILDKHPNVPAQFVHVLHMNESIVSGTPINNDNLRKAEATAQSLRSLHRDHAEISEEMVETAVNRSTMVRATHAEIQFGQGNGAVLALLQGLTQAVAQLNTTVRQVKVNGDRVAAIAMNSRIVWRNRDRRPDEPYTWRQKEVAGSGADLVAALYGARNPLTEQNVQELGAATLGSVPGPQHTLNLHGASTHHDIARMILFYNENFGIVAADTIDVRRARLIYWLGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPW9</accession>
    <name>A0A401GPW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615155.1">
        <property type="nucleotide sequence ID" value="XM_027759354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPW9"/>
    <dbReference type="STRING" id="139825.A0A401GPW9"/>
    <dbReference type="GeneID" id="38781159"/>
    <dbReference type="InParanoid" id="A0A401GPW9"/>
    <dbReference type="OrthoDB" id="3193283at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="542" mass="60483" checksum="9A60A973B6029C13" modified="2019-05-08" version="1">MSAMKLAEALLANIQKQAGHLSLNSAQFLNWQSPVNRLPPDVLSMIFQFVPDLPYTELDYVLWGDNGSPPWLPYYVNVGPCVQLTHVCRYWRHLTLNLPTLWANVVDSERSDVPISVVLQRSQAVPLNISLLGRPSPGMLSFLSYGGTERVRSVWWEGDSSRECPIYLNFPAPKLESVSLMGEVTEQDRHVRVSSIFKGHTPRIQQLFLASMSWLPSNNMPSLTHLNLSGYACPGLSSKILSLLERTPNLVDLGLSNIRDSSILPESRVISLPRLRRFSYRPGDGATGLGSILPHLALADDTALCMHVAAPEELARPVGLSHLPAVKTVVRACVVQDVYVCDFMAVGPASGFDVCIYTADSEDFDAMLKLALEELPLVQIKELWVVENPVCCEMTPSGRDSFRSVLHSMPDLENLVVMEESLDNLVDALLASPDPLRPPLSRKNMTVHIIMERSGVDPSTVSSLIGRLKEVDVAHIIIGYHKTYTGPRFDDAPSLLRGFESVESRYHNTLPLMDMPPVCTTYSHFYWPSWLESWPRQLDRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPZ4</accession>
    <name>A0A401GPZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0602660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615201.1">
        <property type="nucleotide sequence ID" value="XM_027759400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPZ4"/>
    <dbReference type="STRING" id="139825.A0A401GPZ4"/>
    <dbReference type="GeneID" id="38781205"/>
    <dbReference type="InParanoid" id="A0A401GPZ4"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="331" mass="36351" checksum="22FA7C676C398F73" modified="2019-05-08" version="1">MSVFYDPVNERELEDAYAIEALGYPEDEAATLETFRYRQAQAPDLFLGAYLSKEGGRTLIGYVCSTLSPSTSLTHDSMSTHVPGAASVCLHSVCVRPGHRRKGIALGLLKEYTARLACTPGYERVLLIAHEELLGLYEQAGFQLVGRSAVVHGSRPWFEMQTLLTPAPPQEPQQVIPVGLWEALQSSSTRARLRARLLTAFPGGVQDVADASENKFDLLCPREGCGSVILKSGVASLVERESLRLEPPENPPHSALPPLAAPPNLMHWWRVTPNAMAFENIGFSRAVKSDTSTNKRLKLLLCAECDLGPLGWCEEGSSEFWLACNRVGYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ16</accession>
    <name>A0A401GQ16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615226.1">
        <property type="nucleotide sequence ID" value="XM_027759425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ16"/>
    <dbReference type="GeneID" id="38781230"/>
    <dbReference type="InParanoid" id="A0A401GQ16"/>
    <dbReference type="OrthoDB" id="3270460at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="18192" checksum="E1E18C7F14A94C53" modified="2019-05-08" version="1">MLHRSLDLYPLLIVDNKPATVWLIGEVDSSWFKLRGEPLAVVSIKIGSNTSDVLKASRFQSTGSGEYASVEAFQDIFDADTKFGPRNTMRQMHVTDIHKNDLVLVECNVTAFMMAMVCNTVITVKGFVVQDWVKLEEMACQYLCFNKLMCDHLPGDTCSYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ34</accession>
    <name>A0A401GQ34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SCP_0602900</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615225.1">
        <property type="nucleotide sequence ID" value="XM_027759424.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQ34"/>
    <dbReference type="GeneID" id="38781229"/>
    <dbReference type="InParanoid" id="A0A401GQ34"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000650">
        <property type="entry name" value="Serine/threonine-protein kinase ppk16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1354"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="42"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="22">
        <location>
            <begin position="1290"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="300"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="408"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="613"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="692"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="813"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1128"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="655"/>
            <end position="669"/>
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        <location>
            <begin position="698"/>
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        </location>
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            <begin position="723"/>
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    </feature>
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        <location>
            <begin position="779"/>
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        </location>
    </feature>
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        <location>
            <begin position="813"/>
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        </location>
    </feature>
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        <location>
            <begin position="826"/>
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        </location>
    </feature>
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        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
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        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
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        <location>
            <begin position="998"/>
            <end position="1015"/>
        </location>
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            <begin position="1062"/>
            <end position="1072"/>
        </location>
    </feature>
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        <location>
            <begin position="1130"/>
            <end position="1141"/>
        </location>
    </feature>
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        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1192"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE84312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1379" mass="149000" checksum="26049BDCAA6F7844" modified="2019-05-08" version="1">MTSDGHRHSTSLSQNHKAQLANAYNELGKELSSQRIRVVGNYTLGKVIGEGTYGKVRLGVHRLTGTRVAIKQIPKAMSASLTREIHHHRQLHHPHVTQLYEVIATESNIWLVTELCSGGELFDYLAEKGRLDEAETRVLFGQLCLAVAYVHEKGIVHRDLKLENVLLDERCRVKLGDFGFTREFERGTLLETFCGTTGYASPEMLLAKKYLGPEVDIWSLGIILYTLLTGTLPFDDDDDSVMKEKVVKGVFEDPEWLSDEARDLIKSILQVDPSVRPQISQILAHPWFTPRSLVPIHAVASQTSSPIGSRPPSPPTLRPASPAGKSQPPSASSGNSHSTYHSASSEFPTSGPVTPDDRATNKSFSTQSHPDAEISEGILKAELSFLDQVRAAQPNVLLEDDLETLPELEEASPREVPSSPDQIPPRLSLSRPISGSNASSKVPPAYPPRTPARTKRRSVSSTLSDPSTPTFDKSILPAPQQDFSSLLITPAPIIFSTPLERDLLNSLSNLGLDTGQIVHSVLTDACDATGALWWLLKRKAERKALEEGTSKSTPDTVEVQEDLKRYDALKMENSKSPIEDKGTVSSRANTPGESIPSISATLVSAYSAPELQFIPPTPTVASTVTPSTPPRTKSPNNPLLSPSHSIAETATRSHPSTPGGSTNSSNSGSKGRKNRSGSVSIMQRATTALEAAGLVRKKSTEVVREKERNSEKRVTSGEESRPSHGSGSSRTAKTPPLRAMKDAGVPATPPSSMDAQLPAMGSPWIMAGAKGSPPPTGSPADTLSALPNISGSKIGNRNRASLLSTFRMWFKEDPKGKRKEEIVIPTASQSFPQTLNSPTTSPAQGRTRGAPKRRGSGSRSRFATGRKAQRAKRASVSSRRSSSVNSRRSSVHSAQFAMLESPPFSADQVASMSRQRNDPARRSFGSHTPNSEREEFVSRPSSVRSFTNQQRHRKSPSVSSTGSMYPARTASPLPKYHRRGGSGSSTRVIRQMQAAPQSHLRSNSASSVHSLASSRQGSSYELSESDGRRNSSPVKPTPRRSLEETPRRAHLPTTFVAHKRQTPFSNPSGSGYLNSFGRSSWKKSWGLEPPGWQTRSAHPAIEVLAISPAPDAPLGIRDVFSGRQSLSMGDESDWVDEDDDGPGYAGYAGGLGQMPAIASSSTSPYPQIVDTPLLSPPPRGGFSRATGKRTMTNTSSGSGSAAGRGTRGKAGRSPVGRSSPLPTEPSFEPADTRAGRRQLPAGRSGPAFRHPIQEEDEDPQPKAMSEPYDPYLPRGGSSSNPPGPPQGNPKTAAIQQQIDDTVGIMRENITKVAERGERLDTLQNKTDTLAVSAQGFRRGANRVRKNMWWKDMKMRIIIGVAIAIIIIIIVVSVVKATHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQF2</accession>
    <name>A0A401GQF2_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SCP_0603690</name>
    </gene>
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        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027759502.1"/>
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            <begin position="1"/>
            <end position="212"/>
        </location>
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            <begin position="231"/>
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            <begin position="1"/>
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            <begin position="67"/>
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            <begin position="299"/>
            <end position="317"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84390.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="628" mass="69643" checksum="DF6CD5C7CE0B30C8" modified="2019-05-08" version="1">MARRKDTGPPDVIEPRTLRSRSKPDKVASEALPPLPRRASAKKRASLAVGDIHVSHDEDESQVPPKPRPKPKLQGKGKKRARCKAPAGNVDADEHDAADEHDAADEHDAADEDVPTDVSNNRKQPLRKSTIQMTHSTVEEVNSDDLEDVALPRSKRTRRDPVTDMAPPLVPLPSEGMEEHADSDVPVGSVNPGVDMPAILSDDNEEDAPGDDELGVEFDVIMHEDTAAVTDVMGIDTSTDGDVRQVLDREGNNVGQERRSESCNEEHDELDPSGSDYAKTRDQEMLRRSKSLRRCADNVDTETEDDEDDAELQDEVTSDPAVSMHRPKMSSNIQKRGKDRATSPQADDSEVRAADNWLKTPGPLSKEAREQAAELGENILKMAANIGRKYGKSTRDILVHAGLSFKPSRAANPTNIYRHWYSRKHPKMKDVSSADYLKMINVAYKKLFKNVDPDDEDGRKAVIKSIHVMCDDREFDDANVGPTSMKSITARMMSAKDQFTDLAASYRNLADMEVVGAILYVGTDTAGRQTSAIFGGSPAVKKLVEDNGLDVHTFLDFLTTSLKSSHFSLEGFNLPTKFGHSIVVEAKVKENPHDRYQHIFTGMMQETLQQYDPTVVRVHWMNWLKIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRB5</accession>
    <name>A0A401GRB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607710</name>
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    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027759903.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="38781708"/>
    <dbReference type="InParanoid" id="A0A401GRB5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22011" checksum="09F7B9976307308E" modified="2019-05-08" version="1">MVSPHDRTSIPTMTLCHEFGPISRAKAILSTHRRTKRVYAFEASPHAQLGYEHALTPDAADANLTLDRACSGCRPQSEPIGKVGAYYREFEAWGEVFYTAGSTHHRHPSEGTFMYLDLRHAARHGASQQIEARVFAAKRDARYGDVRLGLWEAGHGGGSSLPTRNVMRSFVTGTVGAFVAACLLWVVVLDVLSAAGQLKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRN7</accession>
    <name>A0A401GRN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0700090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615742.1">
        <property type="nucleotide sequence ID" value="XM_027759941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRN7"/>
    <dbReference type="FunCoup" id="A0A401GRN7">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRN7"/>
    <dbReference type="GeneID" id="38781746"/>
    <dbReference type="InParanoid" id="A0A401GRN7"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="182"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE84829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="275" mass="29426" checksum="A943EE04D9ED990B" modified="2019-05-08" version="1">MSGQAKPTFYQSLMAGGLAGTSVDLLFFPIDTIKTRLQSSKGFLRAGGFRGIYKGVGSVVVGSAPGAALFFCTYDTLKQTLPFSPDLAPLTHLVSASIGETAACAVRVPTEVIKTRTQTSTYGKMASSLDAAKRVLADEGLRGFYRGFGSTIMREIPFTSIQFPLYELLKLQLSSSLGRRPLHAYEAAVCGSFAGGVAAALTTPLDVLKTRVMLDLRDTSKEKLPSLTARFKQIYLTEGVSALFAGVVPRTLWISAGGAVFLGAYEWTVHTLMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRP0</accession>
    <name>A0A401GRP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0700560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615789.1">
        <property type="nucleotide sequence ID" value="XM_027759988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRP0"/>
    <dbReference type="STRING" id="139825.A0A401GRP0"/>
    <dbReference type="GeneID" id="38781793"/>
    <dbReference type="InParanoid" id="A0A401GRP0"/>
    <dbReference type="OrthoDB" id="3253976at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="131" mass="15119" checksum="DB115E7A8A332E1D" modified="2019-05-08" version="1">MYDSAVLVQQYKRFRGDSEPAAQFVAGAITTHRYFSTQRLFEERLGTGTLVQQVTPCIFTVGTHPFFFKIPVTVKLSDAVSFRQYPSTLTEVTYHFPDLPRPDQRWSEGMRPLDNLRIIFGCLEAFEEFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSD6</accession>
    <name>A0A401GSD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0703370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616064.1">
        <property type="nucleotide sequence ID" value="XM_027760263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSD6"/>
    <dbReference type="GeneID" id="38782068"/>
    <dbReference type="InParanoid" id="A0A401GSD6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15495" checksum="F4333AA640B8C9D5" modified="2019-05-08" version="1">MMVNMSYVSVASRDDKPALRLNVEIVMVAALVCFIMVIIAFVFVASSRHHSASPSTDVTATSHPRRGINIAAIVAPFHRDTSPRDPESDHNEAQAHDDVSLATSVTTVSRHPSTLSGSTAVEGIQNHAVSPSTTKMEEVDANSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSK9</accession>
    <name>A0A401GSK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616131.1">
        <property type="nucleotide sequence ID" value="XM_027760330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSK9"/>
    <dbReference type="GeneID" id="38782135"/>
    <dbReference type="InParanoid" id="A0A401GSK9"/>
    <dbReference type="OrthoDB" id="2844016at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019560669" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22714" checksum="27EC1D05F4E07CC4" modified="2019-05-08" version="1">MFFLFAFVPLALAALTLASPLYSRQASGPCTGISGGYDSMYNFTLAAFNLTLPNANSTGAPLVVRFNQWTGSATASYFSALSTYYSAHSNNEPTLSLVNGSLIPSNPADADVSSTNLAVSASSQLLFEFSTEESELPAPIQNYCIIDSPDSPYPILAVNGVTDAFSLCESDTPYYFGIPNDVMFQATEDNGHTYNYTSCYPVRLQVVYEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSU0</accession>
    <name>A0A401GSU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616190.1">
        <property type="nucleotide sequence ID" value="XM_027760389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSU0"/>
    <dbReference type="GeneID" id="38782194"/>
    <dbReference type="InParanoid" id="A0A401GSU0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019215989" evidence="1">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="62" mass="7311" checksum="B82231DDB91A1DC8" modified="2019-05-08" version="1">MVFASYCFLFIVTVLICPPVCLTPSYQWWYSGEAMSSYEMNEERGTEEKLVTVVKLYLSNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSY1</accession>
    <name>A0A401GSY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616238.1">
        <property type="nucleotide sequence ID" value="XM_027760437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSY1"/>
    <dbReference type="GeneID" id="38782242"/>
    <dbReference type="InParanoid" id="A0A401GSY1"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8652" checksum="F3AA2EB5275E1A40" modified="2019-05-08" version="1">MALREHLRKYYGGKLLSAIENFDAPQDMEVHWVTEALDHNSIDRPFIAYGNEASVGCTYMHLCLIVEIGKAGERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT00</accession>
    <name>A0A401GT00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616258.1">
        <property type="nucleotide sequence ID" value="XM_027760457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT00"/>
    <dbReference type="GeneID" id="38782262"/>
    <dbReference type="InParanoid" id="A0A401GT00"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="52" mass="6107" checksum="9D0421BC0DE6157A" modified="2019-05-08" version="1">MRYYDHALYIHTRYKLHVIDSNVRMSAYVFSFEDLGELSLLGLEGFAPKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT04</accession>
    <name>A0A401GT04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0704860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616212.1">
        <property type="nucleotide sequence ID" value="XM_027760411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT04"/>
    <dbReference type="STRING" id="139825.A0A401GT04"/>
    <dbReference type="GeneID" id="38782216"/>
    <dbReference type="InParanoid" id="A0A401GT04"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11491" checksum="04A03F74A2FE6BFF" modified="2019-05-08" version="1">MFWHVYDTLEHGLGQHSMHPMSSTYKPALFARAAKISTYGYISHFLQVAESSWRAHPAHVALMDPPPPALTAYLSRLESVSHSSDPSPLLAHAYVRYLGDLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT96</accession>
    <name>A0A401GT96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0706480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616374.1">
        <property type="nucleotide sequence ID" value="XM_027760573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT96"/>
    <dbReference type="STRING" id="139825.A0A401GT96"/>
    <dbReference type="GeneID" id="38782378"/>
    <dbReference type="InParanoid" id="A0A401GT96"/>
    <dbReference type="OrthoDB" id="3006363at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="341" mass="35737" checksum="7F4505CF1F9D4BC8" modified="2019-05-08" version="1">MSSSNSAPSGPSFVFIDDQSGAIQYAGDWAPSDYPSAVANNGTVTLGLAANASATYAFTVPDGEAMIIAVFGVVLPANASGTLPISSYTLDSASAVQYTPPLGAAHAKQVGFYESPPLPPGPHELVIEVEKVPDPDAYPYMLDELVVMEGAISGPPGAHGVSAGAIVGAVIGSVALLVNVLGLLGMFFYFRRRARRRDGARRRDEMGEHDEEKPFVPTPYTIGEDSPEREPIPPNSSGKRAIESPAPAPRSPEVRMWETPVASDPEVRDGAATHIVPHDMARSTGVVQPSGDCVLEVGPRERDGRAAAPVVSGGGERRLSMSERRQGSSAPAEAPPVYSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTM6</accession>
    <name>A0A401GTM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0800560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616452.1">
        <property type="nucleotide sequence ID" value="XM_027760651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTM6"/>
    <dbReference type="GeneID" id="38782456"/>
    <dbReference type="InParanoid" id="A0A401GTM6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="85" mass="8500" checksum="2FAACFFFAE8D4A93" modified="2019-05-08" version="1">MANRGPPSISDLQNQIRALSADVSQTEAIALKVQRAVEIIRAALGINTGGVSPSAPPSTMPPSAAPPSAAPPSSAPPFSNVTEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTS8</accession>
    <name>A0A401GTS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616541.1">
        <property type="nucleotide sequence ID" value="XM_027760740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTS8"/>
    <dbReference type="GeneID" id="38782545"/>
    <dbReference type="InParanoid" id="A0A401GTS8"/>
    <dbReference type="OrthoDB" id="107839at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="93" mass="10620" checksum="C8ABDDFF2F1044B9" modified="2019-05-08" version="1">MVVDANGSDAEEHKAEGYKREDDSYSIPTSQDIPPTSPQKHMASEARVCAFPRCREKAMEGSEYCIKHNLDIRARIIRSFVMRAQSWWESSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTZ3</accession>
    <name>A0A401GTZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0802230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616614.1">
        <property type="nucleotide sequence ID" value="XM_027760813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTZ3"/>
    <dbReference type="GeneID" id="38782618"/>
    <dbReference type="InParanoid" id="A0A401GTZ3"/>
    <dbReference type="OrthoDB" id="3317898at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="251" mass="28910" checksum="FEA5421C54F4A148" modified="2019-05-08" version="1">MPPRTSYRPSRQDEAFVRDMTERYTYYLFTAAACGRKVRAMGYGEARMQPTYDQVLHDWYNDSTIILRTNSTDPSRQAAFFRQCNEICARPLNNLYTYFWVGFAATAGAQGLHCLFKDHPAKYKILKDAREESLRRTYGEEGVQELMNSASLLNPHPVDPTMNALEHVGDVVRYKDENNNIVECTIEDAGHSIVKGNFFKLSYGGGQKEVSYEEMALIWRNRVSLVTSRSEIRPFLGFVWRVVSERLVTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUJ4</accession>
    <name>A0A401GUJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0803810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616772.1">
        <property type="nucleotide sequence ID" value="XM_027760971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUJ4"/>
    <dbReference type="GeneID" id="38782776"/>
    <dbReference type="InParanoid" id="A0A401GUJ4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="295" mass="32361" checksum="FD37CC1B7DEC8CCD" modified="2019-05-08" version="1">MSAVMAQQDDVDKARRRVEGKLSTILHKCGDGAHSNIAVAVAPLEFVDDDVAASNTDAYIPFMAQQDDVDKARRRVEGKLSTILHKCEDGAHSNIAVAVAPLEFVDDDVAASNTDAYIPYRRLPALFPDPPPVAGPSVAQRQCHKVTSSSPLSFHRLLSGAQSLAMPPKLNRSFVWKSRVNVYAYLENSVKASEYSFVAQRSISCMNIFEPFSIQESDVIGFFTLANDAWMYMMASEVSWRKLSLQGGGILIWAKHGVTSLRDVDKVIGHRTLGLRRPEAGEMFAPHQPGATSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUQ0</accession>
    <name>A0A401GUQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0804500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616839.1">
        <property type="nucleotide sequence ID" value="XM_027761038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUQ0"/>
    <dbReference type="GeneID" id="38782843"/>
    <dbReference type="InParanoid" id="A0A401GUQ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019432574" evidence="2">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="138" mass="14945" checksum="678461C8BD60373C" modified="2019-05-08" version="1">MVATFVLFRTFSVFALFFGNTLLAQAAPVGSYGNARDSLLVLDSRIPLDLAKRSGCFVRGDFSGCLREDTSEGEVIDVAPELDVRVVEPVEVAPSEESSKDKRSGCFMRGFFDGCLREDSADSVEEEPAAPPEAPVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVX7</accession>
    <name>A0A401GVX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropomyosin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0902550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617289.1">
        <property type="nucleotide sequence ID" value="XM_027761488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVX7"/>
    <dbReference type="STRING" id="139825.A0A401GVX7"/>
    <dbReference type="GeneID" id="38783293"/>
    <dbReference type="InParanoid" id="A0A401GVX7"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="123" mass="14428" checksum="35B97DFB121BDCDB" modified="2019-05-08" version="1">MERIKERLQSIRAEADKSIARAEEAEAKNKKLEQALLEKEQLNQSLQKKVEILETKLDTSDASSKDTKEKLRQLDIRAEHLEKRVVRLEQERDEIEKKYEDVQAKYTQSKNEMAELVASMENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVZ7</accession>
    <name>A0A401GVZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0902750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617309.1">
        <property type="nucleotide sequence ID" value="XM_027761508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVZ7"/>
    <dbReference type="GeneID" id="38783313"/>
    <dbReference type="InParanoid" id="A0A401GVZ7"/>
    <dbReference type="OrthoDB" id="2210012at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="322" mass="34732" checksum="B47D6BC24FF1A101" modified="2019-05-08" version="1">MDAMDLNWCLTCNRHIDAEGAAPYCSRECLSSDKPSTSALVRPSPFFDPRRVADDLSDLSDELDYNYPEPSTHSYSQCEQELAPVGGRGAWIGKGAAGIHAWARGVKPGPPSDCASVSSTASLRPPKLLLTHCRPVAPTLCMSKTVLAPVEPSRPVLNPRQSLPSLLAHSTTDTSADSCITPSSSVSLATPVSGSEDGAPRRQKTLIGALRAQFRAWAASTAAQNECQRSATLTRESHRTLSRSAREPSLDCVSMEDGYVALAVDGKLALGLAQEEWWESSTFGIVEKVGQAIVPRASRRHMRMEDHRALMARGRKASRGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW55</accession>
    <name>A0A401GW55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0903350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617369.1">
        <property type="nucleotide sequence ID" value="XM_027761568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW55"/>
    <dbReference type="STRING" id="139825.A0A401GW55"/>
    <dbReference type="GeneID" id="38783373"/>
    <dbReference type="InParanoid" id="A0A401GW55"/>
    <dbReference type="OrthoDB" id="3167181at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019532118" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26111" checksum="F08A139838504DB3" modified="2019-05-08" version="1">MFFFLYVLTFLSALAATSAIPRAAGLEAVDWATNAQRLAAGLPLLPPKFKRAFPGQNQARDDPTPAFGAKRSVASSTPVAYSGHIEIKNITGSSFGFLAQNQTGINGVSSNETEYIAVSFTTTTPAAEPFNILISNPAFPSPFYLGGNGTNLLASDSASIVTLGDVVQTAPSAPPSSNTNEESAIWSINSRTQELTVQWINSDSSKVKTYIAYDEADNILFFAGNISVYNAQSSKSAVQVKFYLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW80</accession>
    <name>A0A401GW80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0903220</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617356.1">
        <property type="nucleotide sequence ID" value="XM_027761555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW80"/>
    <dbReference type="FunCoup" id="A0A401GW80">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW80"/>
    <dbReference type="GeneID" id="38783360"/>
    <dbReference type="InParanoid" id="A0A401GW80"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="284"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="220"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE86443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="666" mass="73067" checksum="C6953E09B1E901B3" modified="2019-05-08" version="1">MDDGGFDDLLASSRQVAMENPFENPFANHRAGSPDPWATFGTAQSPSAPHEPETTQPDVFGARSTTPTPDTPSFGSSRFQTELEPLDVAAHVEPESPSPSSPFTLSPGFRESISTIDEAITPTPAKPHPVRESTPPSLIPETPPTSPPASSSASQFAPADASVRVLGHATHSSTTSSSSHASKPEPAFHTPLDQAPRSTFERSFAGLSIGGETVGGWQGSQSAFISGSRSATLPRARGSVSDDDDDDDRPILQSARLMGERSHPASAATSPLPVTSRAENGLQPVFMITVDDPQRVGDPIRAFTMYTVHTKTTYPLFSKSSFSVLRRYSDFLWLYETLSMNNPGVVVPPVPEKNPFGRFHQGFVQQRRLALEKCVQKIANHPVLQKDPDLRLFLESDTFSLDIKHRKAEMAHEKGGLMASIGQSIAGPRFHETDEWFDRQKAYLDSLETQLRGLVKAIDAVTKQRTELAAATAEFAQTIADLSTSDVGKQLSNSFTGLAEVERKAQDLQTIQSQEDMVTIMSTVDEYARLINSVRMAFSSRVRTYHAWQNADSNLKRVKQAHESNRAQGKLPTDQLSRSLALVADAERRALDAKQEFDSVSRLVKSEVARFEHERIEDFKESLEGFLEGMISRQKQLIAAWESYQQTLLKKVAPQRLPTDSPVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX96</accession>
    <name>A0A401GX96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1000550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617726.1">
        <property type="nucleotide sequence ID" value="XM_027761925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX96"/>
    <dbReference type="GeneID" id="38783730"/>
    <dbReference type="InParanoid" id="A0A401GX96"/>
    <dbReference type="OrthoDB" id="2755811at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="542" mass="59231" checksum="6C2F0B0BE42DD331" modified="2019-05-08" version="1">MQKAIHDSAISSIEEGEAKAPTFAGASPEPSIPPGSAFDSESEGQVDDAGETEIDIADSAGDSREDLDYIAPSSDAEDEDEDLGNDSDFDVAMITGKLGGIDAGDEGAEDIGMEPAGLSRSMKGTWKKFLASETARKEKNKKNKTALKSQIIDKHKEALTAPARGASSTATKCKAPASEKLAHENKCAKVVETGGLKPGWRRYLARSDNSSKTSLTHSGESDAPIEGEFDKDEGTEVLRAVRATHQTDDTQREGFTATNLVKIKPVGIVLKPAVIAEIDKKERGAGHVNKQAATSWSNKDLPFPAAWRRQLLVWHHSDFKSTVRLIWMKIFIDLPELDVDGKLRSEHPAIHTVAQAALRTYRSDIGKTALRIIDTIWESADMVGNYTTVERRKAWIKAHLNNKNFLYLDPESTVHLGTFRGPLITETFAYHLQLIIKSEVDYGEPTGALALCTAAVQRALTVWKEGMNSLKEPDGSACRGGARNFKESFKDEPWGNEAKIYYNRTKGLKEPKNNNLTIDLTADSSEGGANVDDDIRMSEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXH2</accession>
    <name>A0A401GXH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1001510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617820.1">
        <property type="nucleotide sequence ID" value="XM_027762019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXH2"/>
    <dbReference type="STRING" id="139825.A0A401GXH2"/>
    <dbReference type="GeneID" id="38783824"/>
    <dbReference type="InParanoid" id="A0A401GXH2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="439" mass="47669" checksum="B5DB2B5D2C6B03EF" modified="2019-05-08" version="1">MVPVITRKAKASAPKAAAKMPLAEGDGMEEAARLAMEAVQAMAFQTGPAAPLQASSSKRMLTPVADEPEDAPEYQAEVAEDERASLERPHDDRQRSLLMPHEMSAGAAEVAQEVTPSLEISKASKGAKSSTLAKAGHLDEGRRPAKRGAPLDRKAAKKEAEAKRDAKANRLRAVPLTSKAPHLRDVQRVSTGSPAPVNEGDTPSGEETSQSSNDDCANCAELRQEFLAHKDGMEVQFQERMADLNTVKAEITAALQRINPPSAFQENARSIREEVKLAMEEFRRPVTIELQESMKLAVADLVAKRHCLPELKEKVNRLEQGANQTVSQADVDKLQGELADLRHSMELQAARSDSMEKELRSLAAEAIAQASKLEMELALAKEDSMTVATSALDEVKKVGKEVATAREETSLVAKSLDAFREKVNPAMVFTAFRPDSHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXM0</accession>
    <name>A0A401GXM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1001760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617845.1">
        <property type="nucleotide sequence ID" value="XM_027762044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXM0"/>
    <dbReference type="GeneID" id="38783849"/>
    <dbReference type="InParanoid" id="A0A401GXM0"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="217" mass="24743" checksum="270AA8ADAA437B2D" modified="2019-05-08" version="1">MWHSSDFLLGVGMVILQPSTDKVVLVYETERKYWFLPKGRKDIGESLEQAALREAYEESGYRVEFLPLFTPTNAPPAPNSDHDFFDFPNTEPFYVSALAWNKRTRRQGRPPRTGDNGGEYLTFWYVGQIPDGAVPELNTGMPDEKNYKSYLLTFDEALHVTQGNAAPMTRKLVCAAYTLLTSTRRTMVAMEQATLLDHLNVDNDHSSGEDRREDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXS6</accession>
    <name>A0A401GXS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1002040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617872.1">
        <property type="nucleotide sequence ID" value="XM_027762071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXS6"/>
    <dbReference type="STRING" id="139825.A0A401GXS6"/>
    <dbReference type="GeneID" id="38783876"/>
    <dbReference type="InParanoid" id="A0A401GXS6"/>
    <dbReference type="OrthoDB" id="3222669at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="670" mass="73813" checksum="D2CF6FDB3EF2D6F7" modified="2019-05-08" version="1">MAALFLHQALFTTEPSASSELPVLRSPNRVTQHERQLSSVSSVTLRTSNSDHSQPTEPLLRPESSIYLDLLSRQPNHPDGPESSFNLGLSLEGDPITPRERKSCLERAIRKRLRRLRWTRRTTLLIMTSWAVYNTVRYYVAFTMFEYRPRQIVLLVLGTCTALSIALVISSLLISAFAPHIGWYHTPHAPHVIVQTVLYYCASVLLLGPAVANLVFVFLWRHSAETIDTLRGRCHWDIDVLWSGVGTQCDGTHSPTWASWVAGSVVRLVLTVAVIITYHWSAYRYDVTRQPSRKYRLFHPRTSVSSVTPLSNSSQTFRPTATMSSTPVTIGQALRRSSLSGTTEDTYESAQTCPQTEQRTLRKSQSRIASRTSNASKDTFQLPSATGVSTARRPSGQITPRRVSGMSAIDDESPKSSDEEDVPGPSETKEFGYYGRQVRPSPGIYASVVSQGPRSSQFNNETSETLQVDPATVTPYSERDLTYFVDRFRTLVEQVARENEDAFPLAAGNGPDGQREHSTANADEHVPMVGRIVHRMPTIESLGSHEVMSLASSGKTHSSNSPHNGSRPSTRTNTQSLSEGYSTPSSRSRANSWDAALALASPVGNRTEEGSVSEMGELTHAETGAPVNTIAITVTNTTTTTASGESRSSNSYYTARTSPQEKIDDEVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXW0</accession>
    <name>A0A401GXW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1003120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617978.1">
        <property type="nucleotide sequence ID" value="XM_027762177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXW0"/>
    <dbReference type="FunCoup" id="A0A401GXW0">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXW0"/>
    <dbReference type="GeneID" id="38783982"/>
    <dbReference type="InParanoid" id="A0A401GXW0"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="263"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="447"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="574"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="673"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="763"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="782"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE87065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="793" mass="86477" checksum="4F0F75F0DD5F126A" modified="2019-05-08" version="1">MSRLIVKNLPAYLSQERFRAHFEATDGPGGTLTDVKLVSRSDGISRRFGFVGYKTSAEAERAKKWFNRTFVDASRITVDVVDGAKDAPPPRPNKRPRLGPSPAEGETSAAGAEGSKPLKKTSSDAQLEEFMQVMRPRTKKGPSWSNEDAVLQPGVTAAIDSHGASSVVGSKEFPNTADASHDVPHTDKDEARTDTISDMDWSKRRTMHAVEADTDAHSERVFEQSDDEDGNREQHEPDAEETHDTEKEESAADPVKTTILQTSRLFLRNLSFSCTEDELQDLFKEYDVSQVRIPLDPVTKQPKGLAYVSFLQPASALAAYEVLDKTSFQGRLLHILPAVDRKAKIEGEGDGIQKTVKEQRDAKRKAGAGKEFNWAMLYMNSDAVASSIADRMNIPKADILNPESDNAAVKLALAETHIINETKSFLESHGVILSSLSGSTRLKRSDTAILVKNIPYGTSTDTLRSLFGSHGELRRVLVPPAGTLAVIEFTHAADARTAFRSLAYRRLGNTVIYLEKAPVGIFSDSSPLDSGGRAKEPVVATGVVPVKAPENLALAAADTVTDADEADLPLSAGTTLFVKNLAFSTTSAGLAHAVRHLPGYAFARVQTKNDPARPQVHLSMGYGFVGFRTKEEAKRGMKSLDGFVLDGHVLSVKWAGRGAEGEGAETKGKARSAKMVVKNVPFEATKKDIRELFGAHAQLKSVRLPRKFDHRTRGFAFLEFISPHEAERAYSMLRHTHLLGRHLVLEWAEDGAADVEELRKKAGVGFGGGKEMPGKKRKLEFAEGEGQEGADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY57</accession>
    <name>A0A401GY57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Polyphosphoinositide phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1003780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618044.1">
        <property type="nucleotide sequence ID" value="XM_027762243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY57"/>
    <dbReference type="FunCoup" id="A0A401GY57">
        <property type="interactions" value="701"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GY57"/>
    <dbReference type="GeneID" id="38784048"/>
    <dbReference type="InParanoid" id="A0A401GY57"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="246"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="920" mass="104913" checksum="9944154224F3C30C" modified="2019-05-08" version="1">MLKFSPPPIQLPPQQSTVANGSAVLHHLEIPPVNGQSDVLSDTSATVTPVSQHSLSSIPESAESESFPIPESLTKSDESKSQSTGVTAPSTRPPSTRAPPPHRDNSFLVFNKFILYENRLRFYIVASNTSDSRHKIIKIDRTSQDELEVVEDEAVYSGKQMSAMLKMLEDGNRGCGGLGKARVLFGIAGFIRFTSGWYMIVISKRSVVALLGGHYIYHCEGTDIIPVCFNHKVDKPAEEQRLMNIYKQVDMSKNFYFSYTYDLTSTLQHNLTRLGLPAPRGTVFNDRFAWNHHMLTTAFHDDKPPSLRAHWLLPLLHGHVDQAKLTVLGRVIFITLIARRSRHHAGARYLKRGVNDEGNVANEVETEQIVSETLTTPFYYPATQGSNEYPRARRPSPNFTSYVQYRGSIPIYWTQETNSMSPRPPIEISVMDPFYTAASRHFDDLFSRYGTPIMILNLIKKREPQPRESKLLDEYTQCVRYLNQFLPSDKRMVYRAWDMSRAYKEKTQDVIGYLEDIAEESIQMTGFFHSGPEPYAHALQNEDDGTGLPWRNTMSLQNGVCRTNCVDCLDRTNAAQFVFGKRAFGHQLYALGVVETPNLAFDSDAVNMLTEMYHDHGDSLALQYTGSALVNRVETYRRMPHWNSHSRDIIENLRRFYANSLLDADKQTSINLFLGVQSERMTPRPPQRGKYQQWFRDEHLEPAYVLEDCERGIQRYVNTRGDYWIEYYRPLLFTSLGKHFAFSMNSTLKLPGKTARDVTYSPFLQHHNSSHHPRLMDGVRRWIGSNPSAGSRNTHVDRGHDHKSKKQKVSVEPDPDSTEALAMQHLDPFVSADEEAEYAEYIDQCQEFFNTADDWAERGDMEKYQHAVAIAHGGSAYLQDAPEDMFAPYIERANPQLVGGGHRDNLTIMYEKFIEEVGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYU4</accession>
    <name>A0A401GYU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618248.1">
        <property type="nucleotide sequence ID" value="XM_027762447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYU4"/>
    <dbReference type="STRING" id="139825.A0A401GYU4"/>
    <dbReference type="GeneID" id="38784252"/>
    <dbReference type="InParanoid" id="A0A401GYU4"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="17641" checksum="D3B478EA50065814" modified="2019-05-08" version="1">MSAAFVMSEVQQNFPLPTPDKYRGAVVEDLQLPPAFALPSTEAISRAIELAYERDFSHIPVLGRNRKPLGYVEVAALKAKWEAGNADPSDKVSQYMTKFDRSQAKSYTLITPSTPLADLEQFLQHNIFALVTDWDRKFVFAVATLQDLENFVSRRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYY9</accession>
    <name>A0A401GYY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1100530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618291.1">
        <property type="nucleotide sequence ID" value="XM_027762490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYY9"/>
    <dbReference type="GeneID" id="38784295"/>
    <dbReference type="InParanoid" id="A0A401GYY9"/>
    <dbReference type="OrthoDB" id="3158924at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="503"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="688" mass="79539" checksum="1FA27BC54902C827" modified="2019-05-08" version="1">MTLIFRDCIGRYIHIYLDDIFVFSDTIEEHERHLEIVFCKLREAKLYLSETKCDLYSWSMDCLGHLIDDQGLHADSDKMSRIREWRIPRSYKEVQRFLGLVNYLGHFMPDVTAYTSPLSDMAHNDRAFVWCPMHTKCFEMIKALACKAPILKPIDPRQPEPIWVISDVSLYSVGAMYGQGPDWRTCRLAGFLSKKFTSAQHAYKTYEHEALTILEALLKWEDKLLGRPIMIATDHQTLKYFEGVTNPMNRQIHWNEYMSRFQYKIQYIEGATNKVADCLSRYYENNNADEFAPIQDYANADARLDPEWDDLLSNRIAELRTGTIQHSAQLPKEVQESRDQEASEMASHLPLVTPTTGAKDEDPTIAKSRTNGPPLKAHLEQDTPFVAAVQKGYGKDPLFRKVVESLTEFSAFVIRDKTIYTKNCQDEEVICIPRVLYHHRMMTEIIIDRGHTTIGHYGPQKMSEYIRRWFWWPRIGRDIEKFCVMCGACQTAKPRNHLQAGLLHSLPIPWFLWNSIAMDFVGPFPRSKGYDYLWVVICRLTSMVHLVLVNMTSTALDIAELYVREIVRLHGMPESIVSDRDSKFTSKFWRELHRLLGVKLLMSTSFHPQTDGLSEWTIRLVSQILRSIVSPNQLDWIDQIPMVEFALNSAMSATTGFAPFELNYGYLPRMIGGLHGTTKFVGVQEFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ36</accession>
    <name>A0A401GZ36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618338.1">
        <property type="nucleotide sequence ID" value="XM_027762537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ36"/>
    <dbReference type="STRING" id="139825.A0A401GZ36"/>
    <dbReference type="GeneID" id="38784342"/>
    <dbReference type="InParanoid" id="A0A401GZ36"/>
    <dbReference type="OrthoDB" id="2689725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="926" mass="105519" checksum="20A0F91D5A17B8F6" modified="2019-05-08" version="1">MGAHRSKGVSRTVRVTTLVFSAHSSAVGRHIKEVHGTVYGATAIAKEKKRAEEMLLQNIAGLSAEKIWALSDMRGDSVVDDSTDNNQQDLPRTEEVGAADDMEWEMLSDDLQNDSTFTTAFRDIAGSKWKPRWYKDMRTWRQRMHHLDENWQPLLPKLVDVYLSWRYGPDRPADEPTEATASADDGIDYNFKTPVLDIYSTVNSVLYKPSFSVEAFAKLLCHFYMIPFRRRYRATLGDAFDIYLTILRMVRKKVLSALGCDMPNWRALNGCPACRYELKDEPSLEFSCMYCMDGNSSLKRLAPVGGRRAGDLRTLADSDYYLPEDFIEKYADEVQSRRTLNKVDVPLHRDTNEDAESDRGEDQTPDGGDPTDGDMGPVSGCTENWKAAAAEEKKKMWGVFEETGIFASACRHGLILWLIDMVRSSELAKYPLAIIAKAMEVFGPHTLAGYDIGCSFEQTVHHSSLGPTFTHLHSRCCVNAFHSYSHFYPCQIRYHPNVIKGMGLEDLETLECIFSASNLLASWDNEKYSNLGTMLYNNYKQVLDIIQTPSVALADAMASLGVCDEDLKLFELEEQQYFATLGQEPEWDVYAMAYVEALQELRAIITQVDEASSWFLNATPTDYQFLPPTNGPTWYEMEMSTTRKLETRRLKMGITNRLQPSDAPYVETVKYIATHKYQLALGKLQRLVIQRLFELHKLNLTQTAYRVCTHISKSLQTRCRAIRNAVTSYNIAAAALNPPRPTLDWDKVSHYSFLEEFNLLHDTHHDIREKQWTQPAMQETMRLHCRIQRAHEKIQRCNIEVRHIYTHIRDEDMLFSTILDDLCHQQDPLHGAVLEYCSRRRVVNTHILAFLQRIYALPGFTGNPFPGERLGVPHSLPVAHSDVEDLLSAEMHELNEEERAGLELDDDDEAEGDISGLVDYVSNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ75</accession>
    <name>A0A401GZ75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1101520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618389.1">
        <property type="nucleotide sequence ID" value="XM_027762588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ75"/>
    <dbReference type="FunCoup" id="A0A401GZ75">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZ75"/>
    <dbReference type="GeneID" id="38784393"/>
    <dbReference type="InParanoid" id="A0A401GZ75"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="170" mass="20198" checksum="368DEC6884C99E48" modified="2019-05-08" version="1">MPIIEYQVVGRHLPTEADPTPKIYRMRIFAPNEVVAKSRFWYFLRQLKKVKKASGEIIGVNVIHEKKPLKVKVFGIWLRYDSRSGTHNMYKEFRELSRADAVKSLYQDMAARHRARFRSIHILRVVEIEKTEDVRRPYIKQLMVPNLKFPLPHRVQKVRSTFVAHRPSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZA4</accession>
    <name>A0A401GZA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1101700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618406.1">
        <property type="nucleotide sequence ID" value="XM_027762605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZA4"/>
    <dbReference type="GeneID" id="38784410"/>
    <dbReference type="InParanoid" id="A0A401GZA4"/>
    <dbReference type="OrthoDB" id="3174539at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53018" checksum="C770E97585114524" modified="2019-05-08" version="1">MDPESTESSLDPISDSMRTLIPLFERLPRTMWRIEQGRFMLLDSPDLTFSATFISSAKQIKVLKWCFNGDITAAALWYILQRWPPQNGPLLPELRELEWVDERAETIPLISKLPGSRLQRFSLATSHIEQAEGVLRKVLPMCPQLEFLSVWAHSSRIIPGKRKDFLGSIFPVGKRTDLSSILRATMSLRVLSLMPGILLSPEEVLALAVLPHLTEASFFVGSDGSSIPRDPVAPGGFPALKKLALYSDTLTEHIPIFLDQAGVIHLSEIILGVCNCPSPDSLHKFFDFLAHSPFNHALIKLKVDVLGNEQTDPAHASEPVGEFTITPRQLEPLLRMGSLSCLEIGVNHLQLDASFLKCLALSLSHIQRLVIMHHRNHVDCKFVPLTDLVPFTEHCPDLRYIGFDVDKETENELGETWKSNSRVECIDCGIHNTQMSEFMLPNLSRLFPMVKKVDWVVWKPESCASRPGICHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZB5</accession>
    <name>A0A401GZB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1101810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618417.1">
        <property type="nucleotide sequence ID" value="XM_027762616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZB5"/>
    <dbReference type="GeneID" id="38784421"/>
    <dbReference type="InParanoid" id="A0A401GZB5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="82" mass="9735" checksum="3D4E6670F594B50C" modified="2019-05-08" version="1">MSEPFTCKRRVHFPPEAEPHPKEMKPSRAVVERLPSSLELVKSVWSDEEHKTLNNSVLRLNLFHPKRSRRILRSLPSYFTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZG3</accession>
    <name>A0A401GZG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1102300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618466.1">
        <property type="nucleotide sequence ID" value="XM_027762665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZG3"/>
    <dbReference type="GeneID" id="38784470"/>
    <dbReference type="InParanoid" id="A0A401GZG3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="137" mass="15617" checksum="FCB4281511E7205A" modified="2019-05-08" version="1">MTVVFVFADPSMFIVGGYLITYAQLAQIGERRGISIPDGEADILNRSLREKGYESIFALPVDWPRRTETTRGRPMILIASRKRHDYLIHLADCVPFEENEDDLKVKGWLAFNGITDAPFTTIPDPLCKYNENGYEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZX5</accession>
    <name>A0A401GZX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1103790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618615.1">
        <property type="nucleotide sequence ID" value="XM_027762814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZX5"/>
    <dbReference type="GeneID" id="38784619"/>
    <dbReference type="InParanoid" id="A0A401GZX5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="8333" checksum="CC4DBACA01F23B99" modified="2019-05-08" version="1">MLIYVPSNPRCFSDARSLRIQMLSRVGHNRSAFCSSVPSPAPPFNAKVIVALVWEQISPSNSLFQFNNKRQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZY4</accession>
    <name>A0A401GZY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protoplast secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1104010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618637.1">
        <property type="nucleotide sequence ID" value="XM_027762836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZY4"/>
    <dbReference type="FunCoup" id="A0A401GZY4">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZY4"/>
    <dbReference type="GeneID" id="38784641"/>
    <dbReference type="InParanoid" id="A0A401GZY4"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="203" mass="21551" checksum="BE9D7DDEC3ACE2DF" modified="2019-05-08" version="1">MSKPSIAIVIYTMYGHIAKLAESVKGGIEASGGSATIYQISETLPEDILKLMHAPPKPDYPIFEPNDLTKFDAFLLGVPTRYGNFPTQWKAFWDATGALWAQGALAGKYAGFFVSTGTPGGGQETTVISALSTLTHHGIIYVPLGYSKTFPLLANLTEVRGGSPWGAGTFAGTDGSRQPSALELELAKAQGGQFYGVVSKVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H031</accession>
    <name>A0A401H031_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1104480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618684.1">
        <property type="nucleotide sequence ID" value="XM_027762883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H031"/>
    <dbReference type="STRING" id="139825.A0A401H031"/>
    <dbReference type="GeneID" id="38784688"/>
    <dbReference type="InParanoid" id="A0A401H031"/>
    <dbReference type="OrthoDB" id="2742885at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="313"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="600" mass="69034" checksum="8E1C5774FA04E6B0" modified="2019-05-08" version="1">MINRGKEALVLSNKWETLYDRLTYRGRQELCTFRGELSLGTDKFNDVFDEECRDLQMKKDVVDGKPKTKLPRKIQQLLSRYKGYSKRLAQAERQGSTDVDHLRVLYSRARNKFRKEQGQWKAKQRELEYSRIADDMASYDFKSAWTRLKARTNLSSATGEGQPMKPSQPLKDDKGHLQTSPEGIQKVMSDHYKKLLQDDKDGQMREYEYWRNKFPYQDEVSRDYEHLGLSAPMEWPECLSSIREMNGGTSPSEDELHIDVFKGMVGEECMAELKIWNPQFVRKDNIQVNLPKKLLPMQPRTPMGKVVFHLLNSAWELGDIPEAWEENTIVSLFKKGDPELLNNYRGVTLISVLEKILTGVMMARLYGTLESAEILDPEQAGFRPGEEAIGQFIALAEIVRRRGVVDEKLRITPTFGIFIDFKKAYDKVPHGMLWVACENMGIKGHMLHMIKALYKRTRVAVRAGGGNAEAFDLWRGLRQGCLLSPILFIIFVTNLLQYIRYQDVEHGVDVPHKMIWDKNQARCLGLLYADDVVGFEGSIEYSRKFISNLYRWREVRSPLLEQVGARSYPPASASPLVLKPEGNTVKLFRNTLKLVAPPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0L7</accession>
    <name>A0A401H0L7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1201790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618866.1">
        <property type="nucleotide sequence ID" value="XM_027763065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0L7"/>
    <dbReference type="GeneID" id="38784870"/>
    <dbReference type="InParanoid" id="A0A401H0L7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019000613" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="84" mass="8647" checksum="7107603D244D4B69" modified="2019-05-08" version="1">MMFFSTLPLAAVLAACSAALASPAVTSTTTVTFINRINTVTYDTTTTVTATSYTTSTTPTTTTFTSTTSTTTVTPTTTTTTVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0R0</accession>
    <name>A0A401H0R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1201950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618882.1">
        <property type="nucleotide sequence ID" value="XM_027763081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0R0"/>
    <dbReference type="GeneID" id="38784886"/>
    <dbReference type="InParanoid" id="A0A401H0R0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8635" checksum="73AFEA8312E97E7D" modified="2019-05-08" version="1">MAPSLERSAGLCRSLQQRVWLIIDEECPLTVSRNDSILQSWGGCCCELRFVKSPRLDIHFGSKIYNVLGLWRTPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1G7</accession>
    <name>A0A401H1G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dual specificity protein kinase lkh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1300580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619156.1">
        <property type="nucleotide sequence ID" value="XM_027763355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1G7"/>
    <dbReference type="FunCoup" id="A0A401H1G7">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1G7"/>
    <dbReference type="GeneID" id="38785160"/>
    <dbReference type="InParanoid" id="A0A401H1G7"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="199"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="534" mass="60450" checksum="9883E6ABCA20003D" modified="2019-05-08" version="1">MQTAVHHLQPQVLPQYPRQSLNRPLNTNPAAIPTPPIAPRKRKRPQQYTVNYSEVQEVDSTGQVREVIIIEDTPPPPTASPASTAHTQIYSASYQPPVYSAHPRTRARAAAEAAQLSASTSSALTAQPAAKKRKRDPADDAGTVTKKANGHLSTVVVPHKTLASGSGIFPETASKDQVPCDDKEGHYIIVPDDMIYKRYRTVRLLGQGTFGKVVEAVDTHTNTRVAIKIIRAIPKYRDASKIEVRVLQKLKERDPTNRHKCIHLLEWFDHRHHICLVSELLGMCVYDFLKENEFAPFPRQHIQSFARQLLGSVAFLHELRLIHTDLKPENILLVNNDYRIVTIPAATGKRNATPRNKRILDSTEIHLIDFGSATFEDEYHSSVVCTRHYRAPEIILSMGWSFPCDAFSLGCILVEFYTGVALFQTHDNLEHLAMMEQVMGKMPESFAKNAERNKPEFFKEGHKLDWPKPKASRQSKKEVRACRSLQDIIPGTDQINKLFLDLVRRLLTFDPSKRISVREALNHPYFNIQIPNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2I9</accession>
    <name>A0A401H2I9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1303970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619493.1">
        <property type="nucleotide sequence ID" value="XM_027763692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2I9"/>
    <dbReference type="STRING" id="139825.A0A401H2I9"/>
    <dbReference type="GeneID" id="38785497"/>
    <dbReference type="InParanoid" id="A0A401H2I9"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="222" mass="25056" checksum="8749D42D3AD304F4" modified="2019-05-08" version="1">MLYTKSHLKSSPRKFIQGNNFSSSYRRKSHYKTLSVPHNATKNQIKSSYYKLSKLWHPDLTKDPRAKEKFQAVSEAYNVLGDDRKRRAYDRTIVAAASIRNPSNSFNDAAYTMHPSYERRRGATHAWEYSRRPRSGQHYTPPPGHAQQAHGHAQHPYARHSDPFSSPNVQRATGKKTTRPVHEGPTEADRISGESTFWRVVQVVGIVMLVATIGGGVSANAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Z1</accession>
    <name>A0A401H2Z1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1401790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619687.1">
        <property type="nucleotide sequence ID" value="XM_027763886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Z1"/>
    <dbReference type="STRING" id="139825.A0A401H2Z1"/>
    <dbReference type="GeneID" id="38785691"/>
    <dbReference type="InParanoid" id="A0A401H2Z1"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="91"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE88774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="565" mass="61885" checksum="D07531B98D78B0D6" modified="2019-05-08" version="1">MRVTRRRRSSLAIGLAPVKPGNYGISSPSPRNVTFAPNVTPGTYVEPEGDQIDELDAASATNTLFPPSETPSPSTSRRREPAGRRRSQGYIPRPANAFMLFRADFVRQKHVPGSIETSHNSLSKIIGNCWHALPLEDKKIWQTLAKKEKAEHRLRYPDYRFRPVHNKEKKAAKKQAKAPVSLSDERRCEEIAAFMLDGKKGDALVEAVRQYDMLRERTETLSPEPQLGLYQPSQIHAPQPMYPHRRSSSVPPPTALYNPITLPSVPFLVGASAFQMGGSRGVSPVNSISRTILGQRRASSAQPMQSRPWSMDMSFAGQGTPEAWQLQRDWEPLPAVNTSLFQPTYLNGNGHEAFGFGAPSGTPSLHEESNDIFNFNGFSNTLSQPVHDLSLSISPLENIPPHAPLSPFSEASSANAATPYSACSYSSDETLGPLDPSRWVPDSGSSTAFSGSPAQSDAPLPGMSNLSPEPAVFAPLAMHSPPFVSWEQQLQTALDAEQQQQHMMHEQNYALEPGCAGGMEMPLDMEHFEFEYEQGVYPPGCAGPDPAVGGEMFGFADPMQTLEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H342</accession>
    <name>A0A401H342_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1402640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619769.1">
        <property type="nucleotide sequence ID" value="XM_027763968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H342"/>
    <dbReference type="GeneID" id="38785773"/>
    <dbReference type="InParanoid" id="A0A401H342"/>
    <dbReference type="OrthoDB" id="2804351at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="200" mass="21467" checksum="C1FDC358B0DD66C8" modified="2019-05-08" version="1">MSAPVDIVRPSSAFVTSDVPSGSPTGKYVPIHKRSASVAPSCGSSPPRHSARSPARGKRARSPSSARSPSSSAVPRARVARPATPIPTHHTIPIYSIPELIALSASPLVQLPSVQRERMVHLFPTIVSHTVSAPTASAPEEKAPLRRRRAGRKSSAKKLQAANVSTDVESRRRRHGAWGWHEHVPLEDSWRHPAVVAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H347</accession>
    <name>A0A401H347_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1402560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619761.1">
        <property type="nucleotide sequence ID" value="XM_027763960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H347"/>
    <dbReference type="FunCoup" id="A0A401H347">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H347"/>
    <dbReference type="GeneID" id="38785765"/>
    <dbReference type="InParanoid" id="A0A401H347"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021600">
        <property type="entry name" value="TFIIE_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11521">
        <property type="entry name" value="TFIIE-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE88848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="500" mass="55748" checksum="0E99E586F0B037C7" modified="2019-05-08" version="1">MSTLTKDEQETLRLLVQHVARAFYEPKYVVVLDQLVRHPVLKDDDLAGRMGLQLKELNKVMAVLDNDKLVRVHRQNELKEGAQRSVGKQYYYIDYQHFCNVVKWRMKKMQKIIDTGLRNELDNKGYICPQCQKTFSPLEVDKLMDFTSNTFVCDICHAEVVENKNSESVLGSQDRMQRFNRQMRFIVEGLRRTEDMILPAFDVALWVKTHIIDAEKAKAAAQGGGLKIAGTSGDAKPEDAIGVVLSVDKDDATQRLERDLEAAAKRQQNLLPAWHLKSTITGDLTALGIRENARTEEDAAAANRLPSSNDVILKGLGVVGAHRPVAEAPKKEEKKPAVVQMQEADYYDRYYASLAASAVPSGQDTPGSDFGDEEEDVKPSIQYLDSLNEYRKRSRSHEDVDGGSATPKLQRMNGHTEMSATKAAVQEAPVAVSGLRGEINGVSGAGDEDMEAVEDVGPADDPLVYVNGQPVPFSQVTEEHQELMTPEEYTKYFEIFSARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3C3</accession>
    <name>A0A401H3C3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADPH dehydrogenase afvA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1402970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619802.1">
        <property type="nucleotide sequence ID" value="XM_027764001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3C3"/>
    <dbReference type="FunCoup" id="A0A401H3C3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3C3"/>
    <dbReference type="GeneID" id="38785806"/>
    <dbReference type="InParanoid" id="A0A401H3C3"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="415" mass="44901" checksum="3DB77A2F0AE7E350" modified="2019-05-08" version="1">MASPALYNSPAPGVSYYTPAQYPAAGTAPDPQPDGKPIPKLFQPLKIRGVEFQNRIFLSPLCQYSAEDGKVNAWHLAHLGGIFTRGPGLTFVEASAVLPEGRLTPEDAGIWSDEHIEPWRKIVEFAHSQNQKIAMQLAHAGRKASTCAPWVHPGAVAPLYANGWADEVVAPSAIPYNDLLAKPKELTKEGIQRIVTAFVAATCRALQAGFDVIEIHSAHGYLFGEFLSPVANKRTDEYGGSFENRTRFALEVVDAVRAVIPPSMPLFLRISATDWLEESLPNEPSWRIEDTVRLSSILAEHGVDLLDVSSGGTHPMQKVKGGLGYQAPFSEAVKKENGDKLLVGAVGSITDGKLAESILTKGQADVVFVGRGFQKNPGLVWTFAEELGTTITMTHQIVWPFFGRGSAGLKTALPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3F4</accession>
    <name>A0A401H3F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619832.1">
        <property type="nucleotide sequence ID" value="XM_027764031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3F4"/>
    <dbReference type="GeneID" id="38785836"/>
    <dbReference type="InParanoid" id="A0A401H3F4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="62" mass="6829" checksum="D3608C3BE2C3E6F0" modified="2019-05-08" version="1">MSNLSSLDSEPTPQAAPPEPMRLFLVNPMETINKLSKSHGNGAIFALPNFRPDVLPELREDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3H5</accession>
    <name>A0A401H3H5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1403470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619852.1">
        <property type="nucleotide sequence ID" value="XM_027764051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3H5"/>
    <dbReference type="GeneID" id="38785856"/>
    <dbReference type="InParanoid" id="A0A401H3H5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22874" checksum="50031074D28E1D40" modified="2019-05-08" version="1">MKISNLPIRTTLLITDARHGYPEERRLKQSVSLPLGDYIDPIIPSGCLCTREDAHLVDRGSFFLPPPVHDCCRHSPRTARPGRRLRNRALNVESGWTAIYTALPPHHLSHQHLPYVQEETLAPLGASSEDMEHRVEQAKLGLRYHQRRTSTPLDARAVHLTIVGNDTRTKHRDGRRHSPHLRCTHAATPWIGRTGSAHFRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4R2</accession>
    <name>A0A401H4R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620315.1">
        <property type="nucleotide sequence ID" value="XM_027764514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4R2"/>
    <dbReference type="GeneID" id="38786319"/>
    <dbReference type="InParanoid" id="A0A401H4R2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8240" checksum="148ECEF9BC995EAE" modified="2019-05-08" version="1">MQLTSVTLSSSAWVSRHLSSWNTSSPALFKTFSNTIKISLSSIEESPAPKKNEMPSFFMEMLKAGASSFVAPARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5J8</accession>
    <name>A0A401H5J8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1602930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620543.1">
        <property type="nucleotide sequence ID" value="XM_027764742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5J8"/>
    <dbReference type="FunCoup" id="A0A401H5J8">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H5J8"/>
    <dbReference type="GeneID" id="38786547"/>
    <dbReference type="InParanoid" id="A0A401H5J8"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="740" mass="83200" checksum="9C0C3E96AA2C9CA4" modified="2019-05-08" version="1">MTSLITSVRSKFLDAIRSVNPPGRWKILVVDEHSQQLLSSVLKQFDILEENVTLIESISNYRDPQPQFEAIYLLMSTSQNVDRIIRDFSDGNQQYAAAHLFFVDGLDEQLFERLTSSPAEPHLQALKELFINFWAIESQAFSVKSPGAFFNMYSPPRSDSAFKSARDRLEEELRFISKTIMNVCITLNEFPYIRYYLPTHHAPLGALKPHASTRAPAPSDASSRWRTNLARGSEARAYETAEGDYVTKLLAFMVQNDLDEYKKANPDFPASDAQRPRSTLIITDRTMDTVAPLLHEFTYQAMANDLLPIEDGTKYTYKFQSAIGAYEDKTATLSDADNVWTAVRHMHMREAIDKLMADFNQFLQDNAGFKGDGAANLNDMKDMLANLPQYQEQREKFSLHLNMAQECMGIFERDKLPAAATVEQNCATGMTAEGKTPKTLVEEMVPLLDGRDVLNSNKVRIIALYIQYRDGVPDEDRRRLYQHARLSMAEQDAVNALVHLGIRISKGPGDRDTKKKLKQKTKNDDVYELSRYKPLLNAVLEEHVTNKLDPSLFPYVKDAPSLAPAPSLRSTPSSQTATSLRSAKPSWHRAARPGASAQEVRQRVIVFVAGGMTYSEMREAYLLSKSLNKDIIIGSTHAVTPLEFVDDLKVLELSGIGSKAIPNGLGEGRGQRPLQQYYDEKYFTQDAPPPQRPAPASIPQPRHEHGRSNKPLIPSFAGSSASVNSSVKEEKKKKRGLFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5P2</accession>
    <name>A0A401H5P2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1603340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620583.1">
        <property type="nucleotide sequence ID" value="XM_027764782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5P2"/>
    <dbReference type="STRING" id="139825.A0A401H5P2"/>
    <dbReference type="GeneID" id="38786587"/>
    <dbReference type="InParanoid" id="A0A401H5P2"/>
    <dbReference type="OrthoDB" id="3269761at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="486"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="280"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="745"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="811" mass="87967" checksum="79E93AD2035A4EBE" modified="2019-05-08" version="1">MSVPLDAVDDAVLFAQIENIFHSLPHLSFSHTVAPPGGQVDELRSLLLEVATTQFKTVMNQVIFALLDEWDSNTCGPHTLFDRLQAIRRVERFEASSIEGDSKSPAAFSGEVMFALMEVSIYRLNDLLQNGGTAMKSDNPATVVPSRGLAILLSFSSKEVSHLRDAFKRRITRLKDIVLECLRTPSENGLRNVLLSVFFRRQVVESLGTTVVRISSWSSVKEVAVSSFIDGFYAIPSLIAEASHYLARITHTMTLQAAEVLTSPVVVSEDVAEKDAGYFARKRARDQSPAHEDLKSASTRDKGKARAPERSGATQGLASYLASKDVKSLTQEKLDNPPSKTPGHRPPFSSERNAEKGPKYTYAKKRARTVSANALKDGQGKAPGSSPAAAQTGRPAIPMKSSGNISSPVLQRLTPSATCQSALPNKKSTVTSHITVIDDDEDGDSGGDDIVEIQQSASATTQVTLVGGVIVREYDAGKGESSVAIGDTVTVRYIETLRGSTIPLSKNTDGDPYIFTVGEGAVPPGVEDGIIGMKVNGQRLIIVPPALGYGTKGTEGVPPNSTVEYPEYQLLENALDSSSTFTEVNSAVVDDVAMRASPKFEGRSFSFQHPHFMPSFILYSETPPLPGYWFSRMDIPNSATFRHRALHEEERCAGTASKMEVDEEKSLISSGELAIGAVNREASFIPSEEPASSTNTEPHVQDEKDKATPLIGFDVIDTFSSGRVSTWSSLRRGLFSPPHESTRVFFRKTHRRKGAGPDLRGSARTPGKEFDQPSSEPRTQQATVSFDSVTLSQNFQQGYADDAAFPPDLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5T0</accession>
    <name>A0A401H5T0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Chromatin Elongation factor SPT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription elongation factor spt5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1700990</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620687.1">
        <property type="nucleotide sequence ID" value="XM_027764886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5T0"/>
    <dbReference type="FunCoup" id="A0A401H5T0">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H5T0"/>
    <dbReference type="GeneID" id="38786691"/>
    <dbReference type="InParanoid" id="A0A401H5T0"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="13">
        <location>
            <begin position="179"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="702"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="15">
        <location>
            <begin position="790"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="802"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="831"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="854"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE89774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1128" mass="123988" checksum="B58B92B1A601124E" modified="2019-05-08" version="1">MSDVEEDTVLHSSGPAEEHEEEHEEAEEEEEEPRKGRRHDYDEDEDEEDEEEEDEEEEEEDVGAERGKKRAKHRHKRPAVNRFLDVEAEVDEDEEEEEEDDEYGKDEFIAEVGGEGDEDDVARRKADHARFDRRERELNDQDLAKIAEDVSQRYRRTAVRYSGDMSDIPQRLLMPSVHDANLWQVRVRPGKERDLVFSLMRKTIDLEYSNRPLQILSAFQRDSLPGMIYVEARSAKQVNDACNGLVGIFPSRGIVLVPIEEMASLLQIKKQDLTVTPGSWVRIRRGKYQGDLAQVMDITENGEEVGLKFIPRIDLNPKDDGAIDGLGKKRKKAGSGLSSFTMRPPQRFFNYEEVVKVYGRKGVSKRNQVYVFQNDTYKDGFIEKDFRLTALQLDNVNPTLDEITRFTRGQDGAENETNVDLSIIAEASRKAAIAVLQPGDHVEVFEGEQAGVHGTVHSIEQDVVTIEPVGVDFDGQRIQIPARSVRKRFKPGDHVKVMAGQNADETGLVVSVIDNVVTFLSDMSMQEISVFSKDLREAAEVGTGTNVVGNYELHDLVQLDAQTVGVIFKTERDSFRVLDQNGQVRLVQPHQISMRRDSNRAIATDAEGHELRVNDNVKEVDGEGRKGRVLHTHQSFFAFLYNRDYTENGGVFVTRARSLVSVAPKGNLMKLGAADLSKMNPALGGGAGGMVGSGNIGRGPRDRLIGVTVVVVKGPNKGYVGTIKDTNGPIARVELYTGNKVITIDKGKLRRRLPTGQVEALEGHFSSMGQPRNNFSINPIGRTPNPYNQGGRTPAWGATGRTPNPYAAVDGRTPAWSASSRTPNPYADTGKTPTWNASSRTPNPYGQDGGRTPAWNSAVRTPNPYNNAQLGGTSPANPSSSSWGGATPGRSSGAGGGWGSPSGGGWGEGANTWGEPVASAPTPFVAPTPAFADPFPATPGMMYGGGMPTPGVGLYETPGAGFEATAETPGLSGGAYSGVETRFEASVKWLTEPEIASKRGMIVEVKNSFGENGWHKGDYEGRQAVVLTVSDMHNQFGARARVRFLQPIDPDVDVHTIPVEFLWPVHPERTEDDALVLHGPQKGQEAKVHAVQQGGVMVVTTKAYVVLEITSEKLCKMWNIDDDGNRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H657</accession>
    <name>A0A401H657_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1701650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620753.1">
        <property type="nucleotide sequence ID" value="XM_027764952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H657"/>
    <dbReference type="GeneID" id="38786757"/>
    <dbReference type="InParanoid" id="A0A401H657"/>
    <dbReference type="OrthoDB" id="2804612at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052980">
        <property type="entry name" value="Crinkler_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33129">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="692" mass="78601" checksum="E4EDC73B2DBF0D9F" modified="2019-05-08" version="1">MPVIRIDDSNSDLSDMARNFGLLYRELWKSNGVEKRNVFLQQSVSVRVDLWDMMESRGSVESDNNSVSDIPGSTFDYTLLDLSWLPRPIAGSAQKILIRQEYLEAMAAFHEDEDPVLLTGQPGIGKTLFLVYALVKRLTEGQPTIFSTAPLKYYLFQNSGAYRFTSADMDGSTLRSAILDLHNGVVPGGNFTEEDAGWILYDSNAAQGPLIWDSEDFLPWKMVFSTLPKLSRYKEWVKQKNAVMYVMKPWSWSEICAGAPLQTSGSRTTKELWDAYHRFGPSARIVYKSDHVEHRNDICFALRNCRDPSILFPQNEAAWDESSNVLVVVEPATIDGVVHRNMLTGKIATPYIMNMVHEEAEHLLGLAMRRTYQHLLADNISRGAAGIVFEDMAHHLLGGTASCTRSLRTLPRGGTRSTTKRKDLTMNSSVIFDSIAQISGNVRQRTYYRPLPHFAGIDSFALIDGTLVLFQFTITADHPVKVKGLESIQTLFAEQPIEREWMLIFVVPTAIEPDFKRQLLQPDSSRREWDQNVDQCVMGLTLEELFPTDIHATKTRRAKDCNELRRRGRGLRMRTWMRLSSLLQAERNWRGRRRHICRHICKLWRGLVSFPNVLGGRMKPSRSWRQHRTHTKVHRPDVGKGCPANRSNAGYKCVACAAISRLLLKIEEKKNRKNSTVCFVAEGSYNAALVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6F1</accession>
    <name>A0A401H6F1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1702560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620843.1">
        <property type="nucleotide sequence ID" value="XM_027765042.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6F1"/>
    <dbReference type="GeneID" id="38786847"/>
    <dbReference type="InParanoid" id="A0A401H6F1"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="2"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="883"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="883"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1019"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="917"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2583" mass="281918" checksum="12B730AE1D973581" modified="2019-05-08" version="1">MSGEVAIVGISAELPSGSYSESNLDHESFYEFLMNRGQSYERLPSSRFNIDAWKGNGLAEIHVDQGSFLKEIDMFDNVEFGISARDARYMAPVTRRLLENCFLALLDSGVDYRMKNVGCFTSGNAFELTNISEPDEYDAKGTFSGLPAMVANRISNHLDLLGPSLPTDTACSSTLTALHLGIQAILSGDCEAAVIGGCQLNHRFLDWFMYSQGGILSKDGKCKPFDTSADGFARAEGCVAIVIKPLEQALKDHDRIYATVLGTAINSTGSGAPPGAPVAESQRDAMIQAFKRAGRQPQEVDYVEAHATGTAKGDPTEANWIGEHFHREDELVIGSVKGNIGHTEIAAFLTSLSKVMSTFKHGVIPPNVNLTNLNAAIHWDEYKLRVPTEPTRLPCRSDRSLVAVACSGIGGSNGHAVIQSPPAAARLCDQSAPNPDRPVLLMACGLSPRSASSVAEGIQDLLKQDQIDLSALSTVLGRRSKQMTWRSFAVLGGSQSSSPVFSNPQHCSRASRSTVMIFSGQGPQHKDMGRVLFEMFPVFRQSVMEMDSVFVKATGKSLRADYGLFDGTPPPEMSDVWPISLILPSLAIFQIALYDLLVSLGVKPDIVLGHSAGETAVLYASGAGSKAMAIELAILRGRVFSSLECMGGTMAAVSCGPSDASELLAQYRAEDPDSIVEIACFNSPSAVALAGQNAAIDRVLELAKLRDVFGRRIRTKVPIHSSMMEACRDEYCGGLRELFERYPGPHVPQISTYSTFTGELFSGPFDAQYFWDNTRSQVRFTQAMEALGRSQNLAFIENAPHPVLSAYVSSMVDQSCPVLSTVRRSKGGKLLSEYNDILNFCGQLTTAGHNCVDFTSLNTRACYELDVRLPVYPFTKKQFPLYPDTAGYAKQMDSRRGPMNHKYMKMNKETHPTLGEHIIRGEPIMPAAGYLEMALEFGASALMNVNLRSILSLSAEAPIKVNINLDGCYWTVNSGTSSSHTRKDAEMATTEILHADGYLSFEEPSPSNTVDISAIRQRCNTYVDTDFYSSLSYFSSYGPHLQRVTNAYLGSGEALVSVRGLDETLSQEGNYVLHPAILDACFHIMTYRPFHGDFNPNVYYLPSFVDAIILHQPRRPKYFPAHVYAHVKLTQWTPDSMYYNIVLADDFGKGLCTLQQFKMAKHRINPLPDISRPFDIVLQPAVPQTLSSDLREVLDNGFSKRRISIKGGDVKVQVTEFKHLSMEDGLSLPQDVQSASDELEYVLLKSSQTLRGAILALGPTKQVVRLLVISSVDELFGEVKNILREFPDLFFEISVTDAQKSELVAVDSRSGIVRVAEIDLTDLTRPPRINVFDFIIMLDKMSLEMNFEAVIQTCSRLLLPGGTLVLTELVGKAVNGRSHNFLQDLVSPSWTSPEYMLSHYLRLLQQAGFIIFSAHCINAATGSHFITAGQPDPRVDDEAGQALFGSSTSLVFDYKFGGEIGLQQKLSQLDVTQKLALWILASEGLDGGSAMGLLRALRREYRSWNIRLVIFPARYTKEMQLNSLRRLPIHIQDEMEIVISSEGEPVVPRILPLSPIGPSVYNTSSSIADSLPLNHVNVSVQCSSARGDISGFLGIVMESNDAQMRRGSLVAGLTADVSQQLSIDAESIRPISNHVACSGPAAASCIPGFTTAIVAPGISTFNHLDRLRSLRILLTHCDTDIGIDVSYVYSTKGVKFTQTTEDARLVDLACLRGGGFDLVISGYTDLPHQQVLKTLLKRGRGRLFLWNDATTGLIGIREHDPCGFGDALGCALDLIEEHMSTMDVGMHQVISTAPKSSALTVVPTRRTLFDPEKTYLLLGGVGSLGAHIAMMMYERGARHIILTSRSGEKSLQSPKKRSPRRLISYLKEQEHLHIQLEAVDATSVAAMQALIASLRRPLGGCMILTAALSDGLFQHLTESDFTTSFASKSGVLNVMKDTVDIASLDFVVAFSSASGLFGVEGQSNYDASNTALEEALSSIPNAFSFICPGILDSSLMAVGDDPSSGSFEHLVEWALSTEDMICWLEDAIYRQLVGQRFKRYIPDLDWEALDRTLGMTKIGQHAVPTWTTTPVSTADRADGIAEVVQKVLSIPPDDFSPEVPLTTYGLDSLSASRLSFVLRPFVEVSQIQLLANMSLRDLQGKVSASLLPSAAGKQEIRRERSEADLMNELVAKYTLDMHPRSTESALHSPPPSEHVVLVTGTTGALGCHIVARLLSMDEVKRVYGFNRTSTTGTALWARQAAIFAAQGLPSSLVDSPKLTLVEGDLAAEDLGVSGDIMDKLVAVTHIIHNAWKVDFGTPLAGFEDLIKGTRRLLDLSTQSTLEILPSISFLSSIGVYQFSDGCPLAPEAPILDAEVAAQTGYLESKWVGERVVQIAAEKMSLRTNVIRIGLLTGSDNGAWDTAHWLPALVQSGPHVGCLPDGNDFISWLSMDLAAAAVVDMRDTMGETLHLVHPRPVTWDTIMKPIAFMLAVPLVPYREWFARLQSSVLDTASASNNSKAGDRVSGSTIDALKLMDMYRLGMKNLNPHRRTSTESMGLLPKVASQKAFHASATLMDERLCPPLCPGDANKWVHYWQSINFLSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6H6</accession>
    <name>A0A401H6H6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620935.1">
        <property type="nucleotide sequence ID" value="XM_027765134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6H6"/>
    <dbReference type="GeneID" id="38786939"/>
    <dbReference type="InParanoid" id="A0A401H6H6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="385" mass="39687" checksum="1388D6BC57CD1F29" modified="2019-05-08" version="1">MEGEPSTEEPQAGPSSSTSSRPSPSDDEGEHDLLSDVSPRGPVQLPPSPMPSDDSSALTSVHYTAARDSDSGTSGRSNPAPAIPDPSPSHVCSPVSVNATVTWELAPALWQFDVLLAPFQFDLDLQPLSLNDTLLRMQWDDANKLTGAFNLTFSAHAAVPFSLDSSSETSLGVPLRASSSNMHTSSPSPSVSVLSARSPSALSPSALSPHVPSPPTPSPSVPSLPAPSHSMPSPLIPSRSAPSLTLTPSGPSMPISSVCAPSTSMPSLPRSSASGVPAPSVLVCPEPVDVSLSALTSVSSSTCGCCRVPQKQHVHEIPVAMEASPAASEGPSATRSSHPARTRVAPKQADVYWSRSGKQQPIVATGQDTEVPARGGKRSAGRQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4S2</accession>
    <name>A0A401G4S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0100350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608076.1">
        <property type="nucleotide sequence ID" value="XM_027752275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4S2"/>
    <dbReference type="STRING" id="139825.A0A401G4S2"/>
    <dbReference type="GeneID" id="38774080"/>
    <dbReference type="InParanoid" id="A0A401G4S2"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="11343" checksum="C8C67755ACB917EB" modified="2019-05-08" version="1">MSTLCTAFTEFPHHHFVTTRVAVAATNDPNSLPTIRASLSGYTVPAAVLTAPYPPSPVEAKYFYYGIPSQPPLVTRSSANVWVKPTGPEAYFDPKESSPIGLHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4T4</accession>
    <name>A0A401G4T4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608094.1">
        <property type="nucleotide sequence ID" value="XM_027752293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4T4"/>
    <dbReference type="GeneID" id="38774098"/>
    <dbReference type="InParanoid" id="A0A401G4T4"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="444" mass="48005" checksum="04B2E7A6F805AA30" modified="2019-05-08" version="1">MFPESIKISDDAVSTNQCIIPLSRGRRKGAARPPISIFGRAAKGKRLIRLTIYPDHKEPMLRPEKITKPAQTAAGGWFAWLPWRWRSSAPAPTSTKPSGLPYAHKLAAYPLHHAAVTRLPWSSDVEARVLPGAYRAIAYFVRLEDQREEAPRILEFHCLSDPRSGSPAAAAAAAQNPCKPLLAAKFAVPREVEELRTVGALAWDETIGRLCIAEGNAMMVHVLDFAESPAFEAEQDFYVFEYPDTDIFDRPYSRKAHETRDVGPGSANEGDWEYSPGPSHGRSSGAGGPGGTTEAGCSYWPSGTQGAQSSREPDATKEAGCSYWPSALDGPEFSHCANGTKGAESSRDPDATKEAGCSIWPSALDGPESSHWENGTDRAESSNRPSRMNGVNRLPDEEMPDWMADWVNNNADLMNGAEEMNGAGQADSAGQGNCTDASVPMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4V7</accession>
    <name>A0A401G4V7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608103.1">
        <property type="nucleotide sequence ID" value="XM_027752302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4V7"/>
    <dbReference type="GeneID" id="38774107"/>
    <dbReference type="InParanoid" id="A0A401G4V7"/>
    <dbReference type="OrthoDB" id="3252992at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="550" mass="59791" checksum="46466F8C018E9C43" modified="2019-05-08" version="1">MHLEIGGLRETTYKLWDTLNEHLSSPQMFHFVHVDPSSNKENSSVRPPPPSAGWVKDPAWIDGSVNPPRFYYNHMEIEVTHRAALTGAFGNFQPAQFSNSATGYRYPLQAAVAPSAGVLTQAEAMAVIAPAPVQLVTIAPPVPVHADMPIAPLHAALAQVEHPLASVQEGGEPPHAEQFQVGNPGAAAPAVQPQEANHLIMLATLSITEKIKTLKFDYIILEGISRTMFITKILGVHDLADQYSPSVHSGPIFKLWFTGSRGGKTSAASTENDRDFSITLETLLHKNKKSCTVSVELDLDSMEGFCTRKRAAVAMQDAVNDDELLYGTKVPRAEGFSEESQLDGGIILQLKQRWPCQQHLGEHDEPGYCYIAPSGEHIGLNMRKLKIWASAIRAHDSTKHEPLNTIEFDGVRDDRLLAIKPRGHTGPHTASMSIDLLMLLMTAMLSLITMLANCQGGLPSSSTVTAEQMAPSQAAGHHSLSPAPAVGQELHTCLAAFAAMKNIDMLEQEGLLSRLELTPDIIPEIPTFHISELTGAVEGHVVKLQVFCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G613</accession>
    <name>A0A401G613_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608511.1">
        <property type="nucleotide sequence ID" value="XM_027752710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G613"/>
    <dbReference type="GeneID" id="38774515"/>
    <dbReference type="InParanoid" id="A0A401G613"/>
    <dbReference type="OrthoDB" id="2960452at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="732" mass="79939" checksum="52AB2A22D1B60631" modified="2019-05-08" version="1">MPRPRGPAVGTPIPRLADHKTCAPPAHAVSSPLWLRFRDRARLDHHADLPACQHQSRAELLAKHAHPLGPNTAPRPTQMRVPTARAIRRAFAAPLHSTSTADTLHHLHSRQCDHHADLPLERQYRAWPTAKHAAPLRAPPPRLSPSHFATARGLTNTRTSRRANPNAAPSPSHNTRTRSVRIFLCYFAYILLTSSNANTVPRPTKTRAWTARAIPHAFAPLSTAPRPPTPSTTYSRQPDHHADLPFECQYRAWATAKHAPPPRAPQPRPSPSHFATAPRSTTARTSRSNAKAAPRPSQSTHLRCVRNFLHTLAPVSAPCPDSECRRTCPNSRTANNSHLARFPLATATMASVTDAPATTTGSKRKMRHLSPSAPVPSPAKRQKPEDSDDIFSPTAHTDSTASDTPADDAHASHRPDETPGKPYRNKGKRVEKTRTPTEVLQSLSKLRETLAVTRAMNNVFVLVQPVYLKRAFPSNIAERLDHVSIATAHDIINLATADPTALHFVTIGASDYLQLKTSTHLTLFSVVGSVTHSDLISPSGRSRQLCVAPSALTWPRAAAVLGAILNRRTLVFPSFHAGLSFSTRLTTGTSNTPTKIRGMAPATPVNAQRGPPPVLPADRDVPTFDGCKPFKFSMRSISMLPKIHDDLSTESAVLLLFTLGKYIKSHPELDDENADTTISLNIQSIILLANPGSMPRGFLEDEPMPLLGVFRPNSEPDQRHSDDSDDDDASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6G7</accession>
    <name>A0A401G6G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0106440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608675.1">
        <property type="nucleotide sequence ID" value="XM_027752874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6G7"/>
    <dbReference type="STRING" id="139825.A0A401G6G7"/>
    <dbReference type="GeneID" id="38774679"/>
    <dbReference type="InParanoid" id="A0A401G6G7"/>
    <dbReference type="OrthoDB" id="3226575at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="557" mass="64299" checksum="5C2B6028B62EDA16" modified="2019-05-08" version="1">MPVHTPLHLTQVKSASSWDEGLIKQYLRQLPEPSVPHNAQIWAAKVVLIKIRLRELRLVEELAAPRIVPAIRSQITAMLLARNLSTWLAFPINNLPVEILIHIFRFVVYSQTNPYDGIRQRMYLTWVCRHWRTIAIADQIPWSFVWYRGRAPWPLAELFLERAGTAPLDIVVEDRSKIPDDQEPPPSLTVEDVDYLMDELSLRIGQIRSLELFVQGYFPTIRIMFWLCACGIPHTMTRFKVYRGLTPFLWELRDSRDIQQRCMIPLCGGNVPKLEELHLDGVGIDWQIFPARNLRSIDLRRIGWDFSPSPERWIAMLQGCPNLYKLVLTATGPRWDDTGIRRVHLPNLRDFALGNVSLQYAQYIFDFMDAPRLMKLTYDTMKSEDYGPLLDVATTFREMKVLAIQGMNFHPTQQNLCRIVKLLEGMSNLRFLKIGDATRQFLDAFMEDPREYREEDPVNESPHANAPLSVLCPDLQYLLVLEQEPDSLIRFLRGRRALGVPFSAAYLDVRFYATLSDEQVKAMRAELTNELFTIRGVSPGPAEEEIDKEIAATVQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6T2</accession>
    <name>A0A401G6T2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0107570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027752987.1"/>
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    <dbReference type="FunCoup" id="A0A401G6T2">
        <property type="interactions" value="382"/>
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    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
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        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
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        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
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        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="2-oxoacid_dh"/>
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    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
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            <begin position="168"/>
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            <begin position="102"/>
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            <begin position="124"/>
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            <begin position="134"/>
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        </source>
    </evidence>
    <sequence length="467" mass="49451" checksum="7090465CC7B5A243" modified="2019-05-08" version="1">MASSLARSIFIRRFHVSVRRHALSKFTMPAMSPTMTEGGIASWKKKEGETFAAGDVILEIETDKATIDVEAQDDGVLAKIIANDGAKNIAVGSTIGIIGEPGDDLSGAEKLASEASSEKPPSPPEEKAPEPPKAEPAPEPTPAPAPAPAESKPQTATKPELPKGERIFASPIAKKIALERGIPLAKVQGSGPEGRIIREDVEKYQPPAPAAPAAPATPATPAATYVPPPGAPLPDYVDIPVTNMRRVIGTRLTQSKQDVPHYYLTVDINMDKAMKLREVFNKALGEKDKAAKLSVNDFIVKAVACALADVPEANSAWLGEVIRLYKKVDISVAVATPAGLITPIIKDVGGKGLATISSESKALAKKARDGKLQPLEYQGGTFTVSNLGMFGIDHFTAIINSPQSCILAIGATQPVLALAPEEERGFKVVQIMKVTLSADHRTVDGAVGARWLSAFKGYLENPLTFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7G1</accession>
    <name>A0A401G7G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0109760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027753206.1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019364292" evidence="2">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
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            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="33130" checksum="923B673189650D2D" modified="2019-05-08" version="1">MRSPVIAFSIFAAAAVSPTLVSGAPTSSNPTTELESAVQRVARQLPNQLSALGLDSSTPQAAAVQPETPDAHRAAEEKLHNPVPASADAADPASVATGSRRKRASDQFTAGGNSYSGASSGTSGGTITNDAQGNDNAGPPTLINDGTAGAVNNAGNGGESTSGFSYGGFGDGEGPGGNAYSGSTGPSNGGSTQNSGNGITNTNANFAGTGGTNESGDSHGGDATGPPSLDKRSGDNNTGGGNAYSGATSNVSGGNVINQGHHEGTITNQGGNNAGIAGSTESGFSTGGDGNGLGPGGNAYTGASGAAYGGGVTNSDSAITNTAGANTAGTGNGVSGGESETGDAQGGNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7P2</accession>
    <name>A0A401G7P2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0110690</name>
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    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027753298.1"/>
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    <dbReference type="GeneID" id="38775103"/>
    <dbReference type="InParanoid" id="A0A401G7P2"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="101756" checksum="917DC2A33419473A" modified="2019-05-08" version="1">MELDWNTRPLSIVHKSREWHPMGPNGTGPSVSSSTLVTRRRSTVLHTPPGPPPSQPIPNVPALPATQYATHERRSTDSESAHHNGTSSQVHPYTRPAASANLAAVAAFSQARLAAASSSTPSSSYTASSSTDNLNLSDSPPVSVLRSVYPKPSSSSQTVVQDRSLLSPPDTRPSSEPRPSSRRALTKALELAREAVRLDSTNDDPHAAVVAYGQSVALLSEVMARVMRGEDGADGQKRQNGRRRSVVAQEEEVRRLKSIHDTYADRMNILSLIYSIPLPPFSPPSTYTSSVSASTESTQPPSPTSPTSETSDAHSFPSSSYRRNFDGLRPSLETARADDSLDEDGDEDAIGVAIPSSVPSSSSRAAPIPSSSNTGLPQSAPPVPTAGPSPNRHSIVPNSRPLRPRASSTLPPPAPPPTTMPPPAPPVAEQDASVSQLLRPTDVNRTRAGSVSHKRTSSGGRLAALHEDVERREETSTELTPTTSHPQESKSRNALLPAQHDHPLPPLPSPSLPETAITPRNPVAAATPSEPSSAHYPAPFTTPRPRGDPSFSAHSDMATPTNKPPLINTSPLLGTISQRRTKASAPPSTGPSSPTDSTTSAASVPAMRLNALPASTVSSLAIVGRNRASSQPGRRPSVVNTGPHGFPTAVGAVNGGPVPRKASIPSRLNPNVAPSITVNTALLSPPLTTAAMMPLVPPPPIPYGNIPTAPLSPLPSLAPPDPLRKPYHMMTLLRQTMTSKTGGYVTRRLHVPQEVWSQGGAKLTNIPEKIRVVEVLCSALEEVHNCSVEYFGAGNVSSGMVMGIGSIGRKEGEAWAAKLEEFSNVCDGVVSNFGKKLGVGEGFVTKKSSGVTSWGGKLTRQFDKFTNGKNLDSPAIYVQGLSKLFHQALILDEHTKAALSHPMAPLYAGFPIDVRTALEMKLRRASEFFAKVVLTFVIRDMALLLDKYVKKCEKWLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8K1</accession>
    <name>A0A401G8K1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0113760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609400.1">
        <property type="nucleotide sequence ID" value="XM_027753599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8K1"/>
    <dbReference type="STRING" id="139825.A0A401G8K1"/>
    <dbReference type="GeneID" id="38775404"/>
    <dbReference type="InParanoid" id="A0A401G8K1"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="216" mass="23005" checksum="FE352CD5EDEA74BB" modified="2019-05-08" version="1">MRLLILGGTGLCGHLLIRDALTASHTVVVYARSPEKLSNDFATNPAVTVIKGDLTDVDGLSKAIEGVDAVVSALGPDKGHPSGTPLAHAYATIIPLMKKYGVKRLIALGTASIRDEHDKFSLSYSAMIIMVSTFARSAYKDIIAIGDTIRTQGDDLTWTIVRVGILTNDEKKDVVAGYVGDGKTRAHLARAAFADFVIGEVEKNEWCGQAPLISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9H7</accession>
    <name>A0A401G9H7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609737.1">
        <property type="nucleotide sequence ID" value="XM_027753936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9H7"/>
    <dbReference type="GeneID" id="38775741"/>
    <dbReference type="InParanoid" id="A0A401G9H7"/>
    <dbReference type="OrthoDB" id="2746456at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65560" checksum="7F2EAE73483FD266" modified="2019-05-08" version="1">MEEVGKRRRVDRRRSAHWPSCIHSASDDTRPRVTSDPLDPMSSTSSDTYADSDTRGSCQRCAKRDIPCIRSRGIRKPCYECRDRHEGCTLPDGTPYRRRAEPDDSSDDDEYSDDDDETSRSASSTSLERDVERPASAPVVAEGQRMERVTTDEPVKGVFRTKVIFKGDKPTQVNIPTLLPIFRIGPPRGVPRTDMLFEPSKRSKLSKSDVERRRLSESSKPAGRSLVPFVTTDSAYGDLEKDEDVGRVTEKRAATAAPAPVSGQATSAKRPRVGFESPLYSLSTSGSPVRHPDFWLRDGSVVIRVGSFLFKLHGSRLEQESKFFAHLFSNARSGQKTIDGCPPYETHVVSSSDFAVLLKAMDGGITYALNPPPFHTLAKLLRTAHTLQCTKFTTYASNVLRTTWPSDPASLTPERTPYAAETIALARKCAVPEVLKRAYYELLRTPNFGQAHDEEDDVSPLGVQDYSRLTTVREKLQAEWMQIVSAPPDHSHSQLASWAEHEALKSRRHCEQAHANGAEMWVQAVVQKPVFTEGLLDPLCALQTLVDIDWSALGYCAHCVDRWRTAWRKRRERIWTDLDAWLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9N9</accession>
    <name>A0A401G9N9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609791.1">
        <property type="nucleotide sequence ID" value="XM_027753990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9N9"/>
    <dbReference type="GeneID" id="38775795"/>
    <dbReference type="InParanoid" id="A0A401G9N9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="130" mass="13908" checksum="D94F6DC2E2A215B6" modified="2019-05-08" version="1">MVLHRDAPTSAQVGKWGSQEGLGTKSDSPSQPHQPLPLSFAQPENAQSARPLFQYRASSPGLRRVVSISTISPIYDETSACARDDRSTIARTDAKLKKAAQSPTGPRSRTLALTQGARTAEHAQVSAPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA50</accession>
    <name>A0A401GA50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0202420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609958.1">
        <property type="nucleotide sequence ID" value="XM_027754157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA50"/>
    <dbReference type="STRING" id="139825.A0A401GA50"/>
    <dbReference type="GeneID" id="38775962"/>
    <dbReference type="InParanoid" id="A0A401GA50"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF160">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019414981" description="MFS general substrate transporter" evidence="7">
        <location>
            <begin position="18"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54128" checksum="31B848039D393713" modified="2019-05-08" version="1">MVSFCLLVLFGFLSGLGGNGGLASAMNSTAKSFPDRARATTNGVVLSGFGLSAFLFSTIAHVVFPGDTSSFLLVLAIGTSLPMVLGFFLVRPIPLPFSELTHNVEHAVTDEDDEDVVTARVGSPTIFQRENNSHTHLLSPHLHHHHHTDEEDDVQELLLEEQSLVSHLHQSSVSSDYVVPVLADSVALSPTRSESRQRSRSEFSASHRRRRLSSDADVRALDGLPNIHGKGLFASSDFWLLFTVTALLSGTGLMYINNVGSISQALFAKGNPDYDGVKASQWQATQVSVISVMNCLGRIGIGILADFTKTYLHHPRSCCITLIAALFILSQVMLYNVENVGELWKTSAVLGSAYGCLFGLFPTLTIEWFGLSHFSENWGFVSLSPMIGSNVLSIAFGRNLDAHVPESETRLNNTITSVASVPVSPFSTASVALPGFGPPSAHQCLDGRSCYVDTLKLTLAACCLGLALAVYAGWRDRRRQHRLGLGGAEVSPEIVWTEQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA89</accession>
    <name>A0A401GA89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial glycine transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 25 member 38 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0202680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>glycine(in) = glycine(out)</text>
            <dbReference type="Rhea" id="RHEA:70715"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609984.1">
        <property type="nucleotide sequence ID" value="XM_027754183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA89"/>
    <dbReference type="FunCoup" id="A0A401GA89">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA89"/>
    <dbReference type="GeneID" id="38775988"/>
    <dbReference type="InParanoid" id="A0A401GA89"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904983">
        <property type="term" value="P:glycine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03064">
        <property type="entry name" value="SLC25A38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030847">
        <property type="entry name" value="Hem25/SLC25A38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46181:SF3">
        <property type="entry name" value="MITOCHONDRIAL GLYCINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="117"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="212"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="300" mass="32469" checksum="88ACAF099F55D41D" modified="2019-05-08" version="1">MSDVRKHLLSGALSGLVSTVCLQPLDLLKTRMQQVDGTFPRSHNAMILETAREIFRTEGLRGLWRGTTPTLLRNIPGVALYFTGLNYTRNILSATSYFSVTPLHPPQTRSGSVLPKLSSQGNLLAGAVARVAVGVALNPVTVLKARYESNMYAYQSLPGALLSLLRSGPSEVFRGVLASSLRDAPYAGLFVVCYEGIKSDVSHLLAPTSATVSAGVHGFSAASAGVIATMATHPFDVIKTKMQVRTEDRYHGLLKTVSTIWHQRGVRGFFDGAALRVSRKPLSSALAWAVYEGMLMFMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAM9</accession>
    <name>A0A401GAM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0204120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610128.1">
        <property type="nucleotide sequence ID" value="XM_027754327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAM9"/>
    <dbReference type="GeneID" id="38776132"/>
    <dbReference type="InParanoid" id="A0A401GAM9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="23259" checksum="04BF15ED10281CCF" modified="2019-05-08" version="1">MDYRYPILADSKTLQRLCETARADLAMVDQFFSWRIPPGSEALQITERLYPCLLTQIRLRMESVRLDIIHMEEEYIPSWYRKHGDPQPRETGTNLVKSPIGRAAIDAIHHLRGSTILYTALRDAYGGYLPEEGKEMQYYYKVMKALFAIAERHLSHIPPGSEALGVVEMLSSGFLSEIEPRVELMRRTAKFLEEVATPLWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBC3</accession>
    <name>A0A401GBC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0206310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610346.1">
        <property type="nucleotide sequence ID" value="XM_027754545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBC3"/>
    <dbReference type="STRING" id="139825.A0A401GBC3"/>
    <dbReference type="GeneID" id="38776350"/>
    <dbReference type="InParanoid" id="A0A401GBC3"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF67">
        <property type="entry name" value="SCF E3 UBIQUITIN LIGASE COMPLEX F-BOX PROTEIN POF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="207"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="4">
        <location>
            <begin position="397"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="906"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="998" mass="108239" checksum="BEDBB8844DBE3309" modified="2019-05-08" version="1">MTKPGHDPKEATLTSGTSVVQALRLTLSPALQQQPSTRVILAANASLRRAAPTLSSNTMYRSQSPTQSSTSVSDNEEDDYNKSAFFPSPDALAISPAQWSSRLHLLPHAADTPPRCQASRLPPEILIHILKHLHSSGDLYHALLVSRAWCECSVELLWYRPSFSKLGTLVKMLRVLSGVDQTFLYAQFIRRLNFLSLAPDISDSLLSRLAPCVRLERLTLINCNNISDDGLMRVLPCCPNLVALDLTGVSEVSDRSIIALASSTKKLQGINLGYCKKLTDNAILSLAAGCPLLRRVKLSNVELITDEPVSALAKSCPLLLEIDLNDCSNITDISVRDIWTYTTQMREMRLSHCVELTDAAFPTPSRPEIITGANPFPSSMGLSSDKLPALRLSRPFEHLRMLDLTACSLLTDDAIEGIISVAPKIRNLVLAKCTLLTDVAVENICKLGKHLHYLHLGHAGSITDRSIKSLARSCSRLRYIDLANCLQLTDMSVFELSSLQKLRRIGLVRVNNLTDQAIYALADRHATLERIHLSYCDQITVMAVHFLLQKLPKLIHLSLTGIPAFRRPELQKFCRLPPQDFNSTQRAAFCVYSGKGVTELREYLMVLFQSMTDADNATATEYDDEFDEEYRARYPDDVETADDGEGADDGEDEDEDEEGSADSTPHPNPILSHGPSGVVDNSDSRTPSRPSPSGAVVRELAMSRDRGNQPVPRQGVLSAPTWLSGPSSSTRVASVPRRSIGFGQQPIVETSTSPAPSDVASNRSTGTNQSHGTAFFRTYAEAPTSARHGVVTPDLVFAEIGHGRGTGPGPSTVFVQGNGRRGAETVMAGTSYGVLSTNSAGYVISPTGSSTFTAALSEVSATPHGFRAPVNDNEGQSDHNHDTRTVLVNSSNSYQHGITPVGWSPSHHQAASRSMSSSPTTRELHESVQSAFESQPVLVESRDTDSRGRSVKRSLRNTLTAAEQYASSFFFGGRGSGGSSHEGAAGLANGRDGDPHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBD7</accession>
    <name>A0A401GBD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0206720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610385.1">
        <property type="nucleotide sequence ID" value="XM_027754584.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GBD7">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBD7"/>
    <dbReference type="GeneID" id="38776389"/>
    <dbReference type="InParanoid" id="A0A401GBD7"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="FAT" evidence="5">
        <location>
            <begin position="2373"/>
            <end position="2930"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="2773"/>
            <end position="2806"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="3214"/>
            <end position="3544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2944"/>
            <end position="3040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2948"/>
            <end position="2961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="3003"/>
            <end position="3014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="3584" mass="407013" checksum="19570323A25C29CD" modified="2019-05-08" version="1">MESTPPLTTAADLDMRAARVADPSIDLKTKLTVACELREMIDTVRDAESSRVLPHMIPVLLQLLKTGEASFQKDALEYQFRRCLLDTLHRIPSTEVIRPQALLIFQGMLYILRHDNEENGITCCKTIMDLVRSFRALNEELLSEFLAIFQEILQNMKGLVDETLSEDSPLMDSNLVLPATRSFKVLAEIAMVIVTFLQVHRPLVLPKLQATLPMCFNFVAIESSAQKRAREDFEAMGNFWTGMAPTIKNSVTYTDYISAEIKVISYSAYVLRALGEQYQSEGEMSEGEILILAALRVLQDCPAMALTARKDLMVVFRHLMLTPSRRALVSQIDKLFDERVLLGTGVGSRETIRSTAFACFADLLHHLRGDLTPAQLTRICTVYIRHLQDPFLTNHLHILSAKMIFNLVEVIVTKDSRQGAGRILTTLLEASVDKIESLADVRVELTDKIEKAKKGESDLVDFTFIEKARPVSAAIYAIEKPEDVIHEYRVVFRTMLHMLRHTFTGLKKCDAPVPDGEIVSRLFVGSIRCLAFYDGEPLRDANEIQEWLGAVLVEANLHVLQEVWTQKIEFFFESVKKRPMLMHLAQVLFTREVLSPTLVAIVLKFLLDRLPLLGEYDAHTAAIAIKMFKMAFGAVTLFPSLNEPILASHLGKLIMDCFPLAAKATNPVNYFHLLRGLFRAIGGGGGRFELLYKEVLPLLPEMLQCLHRQLLASHGASRDLVVELCLTVPLRLTHLLPYLNYLMQPLVLALRGNPELVSQGLRTLELCIDNLTPDFLDPTLNAVLRELMEALHSHLKPVPANHHHAHTTIRILGKLGGRNRRLLDKEPALQWHHFSDPTRARFSFGGMAGSIELGPMSVLAVSALTPGNTLSPYRNHAYGYVEACLTLLLHEGIRGRDKETVFIRCLEGLFDAIHLPELQDKAENNIRELSHFVFNADIRTTTPKERRYPSLLLACYLNALPHGLARENPDEALKAQQLVSTLIHDLVAMANSQGISSQDVIPTLYHIASRFSSLCLEDSWVHRSAGCGGIRIMTHMPDLGMKWIKDRELDLIRTLLHVLKDMPYDLPRDVDEVVDVLIRVLRVGGDDLRVLEGEEGAPGRNKLAALTSLFFGELSTSNAIVRRTAQQCIDLLAELSGRTPAELLLPHRDRMLTAIYTKPLRALPFPIQIGMIEAVRYCISLDPPLPELNDELLRLLHETLALADADDMALLGRGNPRQGSLEIIKLRVACIKLLTASMPLTDFFSKQHQTRQRVTSVYFKSLYSPVPEVKDVAHEGLRMVLTHQSRLPKELLQTGLRPILMNLADPKRLSIPGLEGLARLLELLTNYFKVEIGYKLLDHFRIVADPQMLQASSRQPLLENEGITKLVRLANIFHLLPSAANVFLENLVNAIVQTEAAMHFSGQSPFSEPLAKYLDRYPVEAVDFFMRNLQLPRHVRTLRSILQAKLASNLLRELTLRTSTIVASCFESRNPSLILPGLLLCSDLADLVPDWLVTNCHAVDAILALWKVEPTPLDQSTEYLGDVDQRYTLMLSIFQRALRSTARIDLLFDMIAVFSREHALDMIHMSQFFYSHVAFSSSLTFRRNVLWRFFVWFDDQSVPWSHKTHLLQYVVTPTLLVHSVQTPSKLGLLDNDMVQRIHSRIWKPLIDDVTFSGADDTFKIELLHLTTVMVHRYPDFLQEVKKDIIKCAWHYITSEDPLVKQTAYLLAARFFEAFDGPQKFLLRVWTGLLRPPHNEGKTLVRQALDILASVLPRAQTNEVGYPQWAKTTRRLLAEEGSGASQIGLIYQLIVRQASLFYPVRALFIPHIVNYLTKLGLSNTSTLDSRLLSIDILQVIFDWELQATSSKAMEDTAGDGDTTATAWVTPLAFRETMVSYLVRLATGPQDMQARNNVVSRALALLRLVVGPTGWSDVTVKLHYFSRALEQNDLNGEVALNQAIFAAKVLQVVSSEKDNTWYSENAEILTKLVRKGMTSEDHSLQDSLHLVFDHLIRIFPLPKEEDDHQTDVSDFHSFIYTVIGDNLRNAENLRGNAVSILRGVLLMLKSVVQVTPERIEPFSGPLMKLLYKLTKDHVASAPSTNGFDLNVRLLEAILHICRNAVVYLGDQRKHLLNQMVFLVEKSKSGGLCAFMLDIAREWAMNKRDPYPTMKEKASLLQKMAAFEMRGERGEALFNAYLELIYDIYTDSGLRRSDLTTRLEQPFLLGCRAPDVNIRERFIDLLDMSVPRSLFNRLTYVIGVQSWEALADHNWIFLALHLLLGTVDTDISIILDRKGSLDAATLTPPFTLGRASSLIRPMQRLAFLDPQAAHETWVSVFPAAWACLSRREQVDLTHHMITLLSKEYHVKQSELRPNVIQTLLTGIHACSPPMTLPPHLVKYLAKTFGAWHVAAEFLESSLTRVREDESVVRDTVYDSLAEIYAELAEDDIFYGLWRRHALFKETEVAITFEQCGMWEQAANMYEIAQNKTRTGNLPYSEIEFCLWEDHWMLAAEKLQQWDTLYEVARGENNHELMLESAWRIKDWAENRDTLEGQISMLPDVATPRRRVFEAFVSLLKSPGALDRNQDFTKLLEDAMQLSLRKWISLPPQLSAAHIPLLQHFQQFVELQEAVQIFGSLSTTNAQNLEKKSSDLKMVLQAWRERLPNICDDISIWSDLVAWRQNVFNAINKAYIPLITSSNQTGGTAAGSTNTFGYRGYHETAWIINRFAHVARKHELLDVCFNSLNRIYTLPNIEISEAFLKLREQARCHYQKPGDLQAGLEVINNTNLMYFSTTQKAEFYTLKGMFHAKFGRNEEANQAFGQAVQLDMLQAKAWAAWGKFNDRMFKDLPSDMSYAANAVSCYLQAAGQYKSRKSRPLLARVLWLLSVDDGTLTISRAFDTYKGDAAFWYWITLIPQLCLSISHREIKQARYILLNLAKLYPQALFFHLRTTREDMAFVKRQAAAAAQRSANVDHSQVPTSTSVSLDSHKRAQSDQAMQDSAMDGGSDVVKPFMAGDDASQLHASPGTLRNPSETSQNVARPIDSRRVVSSEARSTADPTFPHPGRASWECVEEVVQILKTAFPLLILSLETLVEHIIMRFKGTQEEEIYRLVSMLLQDALQQYMFRASREDDNGQLPEQIIKYLPRYAGSLSGSPRRDYEEDFLKNKMSLYDYIRKLQQWRDRYERYLNSRPREQSLDLLSHYLTEFQYSKFDEIEVPGQYTEDKDNNQNFVRIQKFGPKFENCHTHGYYWRRITIHGNDHSKTSFAIQLPSGRHCRREERVMQLFRTFNAVLYRKKEGRKRNLQFHLPAAVSCGPNVRLMQNDASYITLADIYDQHCEDSGIAPEDPSLVVGERMKVTLREYKQRHGKLPSQSEYHTLKMGLLDEVTKKVAPEDILTRYMIRTMDGPGELWRMRKQFTLQLCATSFMTYVLCLTSRTPTRFHLSRTTGQMAMSELLPGITSHGPFFASGETVPFRYTPNMQHFIKPILGDGVLASGIMAIGRCLTEPEYDLEQQLYLFTRDEVMTWMHSHGKPWTTDLSFRDNVTSNIGVVVKRAEAMACRAERDEGVPTGPSASMHTVLQTVMKMIADATNPAKLAVMQDNYVPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBV6</accession>
    <name>A0A401GBV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N1221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0208500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610563.1">
        <property type="nucleotide sequence ID" value="XM_027754762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBV6"/>
    <dbReference type="FunCoup" id="A0A401GBV6">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBV6"/>
    <dbReference type="GeneID" id="38776567"/>
    <dbReference type="InParanoid" id="A0A401GBV6"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="4">
        <location>
            <begin position="427"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="971"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="495"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120012" checksum="18A0A48BE95ADFCB" modified="2019-05-08" version="1">MSQDSQSHGQTQVGLDSITLGQLKAMVTSVPKPKQTYYDFRYDDEDTVLNEIEEFYSYVEMPQVAENLKAWEGSFTGEWTKSSFAQRKAHIELLLESLEHRDTEIRFTNARRLLYVLQGTFAETSSAEHQLHWIFENCKVVRAANGLSNIVEAIKIASSKHDLLCSLSDSDASHFNISPSEKADFMEEVTTELSVYLGMLYHMVEVFKGYDDFADELMSLDPPLPVYLFNVVAGLRDKSAKGYPVKKLLLVLWKTLLTCCGGIREIARVKQLSRELAGLPLVSDEAQPIKASPLDIETFRQEISIKYPTFTPPPAPVDIVSPVPVPARIRVVTAKLAQAYSPIPIRHHYEHDEVDIQHTGLPQNSHGLPFHAQSNQSFRPGPQPATPAPSPPPSPKPKKQQFQTDQSRPFLFPFSRMTRYKDARLVPYAIDEADKLYTRHMYVSLALWQMWKTREECMTAESGLDVMPGSEKIAEPKPPQVSSAQDETSETLPDIVRLDAMIAEAEASVAKAESSNDRKKAQQRKEDLMRLRRVEQIYSAVLPVLSGWVLVLLKLLLATVSAATAPPPSAASAGFPPGVPSPLEPAPIPSLDEIDVTRHREITSKAVSAILLLTLKWFKVSHVMKFHHLGQLLLDTNCLLLILKMFGLQEVSVTIVSKADAPENNFFRYCQTNFARSMPSNRPEDNLPKSSRQTVVQTHVLPNGLKRDEEVDVLTDYSWRNFFSTINFAKIMQKLSKHRSHRIRMLVQYKSSAVLKRMLKVQHPMLQLHVLKLLKSQVPFCGRKWRQSNMQVITAIYLNCRPDLRDEWLTGIEVDDVADAQAQEQALRHLVKFYNTKRYGAAAAHQSGTHRRTASISHHLEGLHPGPELSGIIRPLATPNNVDADVFPPLRAQAPDPSIFLPYVTEDIAFEEEYEEYLSDLGWSDEQYASQQQGPLFGGTSAWHRLPEFASDMADGISDSESIVSIGELGEEARLDSGRDDREVPDENLNNWEHMSPKTMAALQKSPAHGRRSSSGGGLRPVLPFELDESSAIDDENEEEEPELGMIPRDSSGPFHAGAGVDEVEYAYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBW6</accession>
    <name>A0A401GBW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0208450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610558.1">
        <property type="nucleotide sequence ID" value="XM_027754757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBW6"/>
    <dbReference type="STRING" id="139825.A0A401GBW6"/>
    <dbReference type="GeneID" id="38776562"/>
    <dbReference type="InParanoid" id="A0A401GBW6"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="485"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="515"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="589" mass="64632" checksum="E491165205FDA38D" modified="2019-05-08" version="1">MKRSYDYSFVTDTNDITTNAHSFTEQTATPATQPSIGDNIALKYEPYSSPGAGTPSPAFRLPLLGETVGFDFDFQPNVAQSSFPTFNSWIQRDDSGRSKSRLTGLGIRYEGPLYATPIGAVFSPVIPAVNFTPLPGSLSDYISDGSNYLSLRDICHIGSSPILEPPESVEKDDRSSNANRKDPAYPLADSYEGAAYSDCPTFEFRAHSPFASSSLPSLSFCSSEGNLSDNSHTSSIKNQMTDILDSLSSPPLYGDARCSEEPIVGLFADVNMLELAARDQGPVLGVNPADIMGPSAYIKAEDVNSPQLSDMADLCYPPSPSPELPTNRSGEVVAKAEFPDELISAIVSVLSATKQEDRRGSAVGQSLSPGNLMATNMTANVFTPHAAGLEVAAPPICFVPPNPPTLCQPHHVPLADIYIPQAQAPRPKPQLQSPVLNAHQGIELEDLRRRADEYRRENPGFELDKTWLQVYAGRLSQRGEFIEDYRCYVIGCAQRNKRRDHILVHVGSHVEHRPFHCGICGMRFLRKNECKRHEGSHAGNKPFSCPICAPVQEKSFVRQDLLKRHMRITHGVQPAQKRARIAVDEDYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBY5</accession>
    <name>A0A401GBY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannosyl phosphorylinositol ceramide synthase SUR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0208720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610585.1">
        <property type="nucleotide sequence ID" value="XM_027754784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBY5"/>
    <dbReference type="STRING" id="139825.A0A401GBY5"/>
    <dbReference type="GeneID" id="38776589"/>
    <dbReference type="InParanoid" id="A0A401GBY5"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000005">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.17, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="526" mass="58780" checksum="629F039141D5EB06" modified="2019-05-08" version="1">MFRRRTVHIFLGLLAAVLVGTVVVLSSISYYLSIDPAAYLTELELDAPFNDTVPWNATDHGKAERIPRILHQTWKSETLPTKWADVSQGCRDMMPDYEYMLWTDASAREFIAEHYSWFLETFDGYTYPIQRADAIRYFVLHHYGGIYLDLDIGCLRRLDPLLVYPVILPKTIPVGVSNDLIFSEKGHPFMEQTIRHLISFDHSWVLNYPTVMFSTGPMFLSAQYGIYSSAHPPSLEKPGGNIRILPKSLYGKNAKPDEAPHSFFSHYYGSSWHADDAAFIGFLGKWGKGLMWVGLVVLILGVIRMFLAPSSKQRNYSLRRIGGYDVMMPRWIQRNGRWHLDLGWFSLPASSGTSTHPPSPISLPSTDEEVQLLPLPFGPRSSSPASSETSLLIDGISTAHTSHSRPMLDVVRRAGSRVMTSIFGPSGTEEVADTPARPRRSRRGQGVLFFLPAFFPHSPPSQDVEAQGGRSTSRSHSRRASVSSTIPPEKQRYMDLESAGLMPVSDLPTHGRIESSSSSEGSTSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCC9</accession>
    <name>A0A401GCC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0210060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610718.1">
        <property type="nucleotide sequence ID" value="XM_027754917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCC9"/>
    <dbReference type="GeneID" id="38776722"/>
    <dbReference type="InParanoid" id="A0A401GCC9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="11713" checksum="744FED86F6AAAF3E" modified="2019-05-08" version="1">MIRSPGYDRGGDDEVGSFRSPVPRKKTHLKRGKFVLTDCMNVYLTLCCVAIQGSSSPSCRRPAHRHFPRRTDAEIAYIASPLSSISAKGYNQTWGPPQFNETVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCL9</accession>
    <name>A0A401GCL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0211040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610815.1">
        <property type="nucleotide sequence ID" value="XM_027755014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCL9"/>
    <dbReference type="STRING" id="139825.A0A401GCL9"/>
    <dbReference type="GeneID" id="38776819"/>
    <dbReference type="InParanoid" id="A0A401GCL9"/>
    <dbReference type="OrthoDB" id="2532648at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="2"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="367" mass="41309" checksum="0BA25E460690EFF1" modified="2019-05-08" version="1">MPSVFESLPVELIADILTELDLTSLVIAAYLSRRLHAVSSDTSLNPWRGPILRTLRNPDGSYEPCLKHLSVRSVVPRLNFVEILSIARAPFLLFDATLPNLRESEWELCFRRRFLPGWAKVKKDCTWREAFVKMLHRVWHRSHSSCTTDEAWTNYIVLNRNGTANQLAGSSRNFNVLTISDQLKVQSNLMHLDTRVRVLVEFADVRILAIGVLNHTTTSLFVNPNARELLHPPGIEKEEEVDGASVSPSSSQSSGTLNQTYRRLAYPHPSPSHENYPFHTPGGEDVRWVDTEELEEKCLQWVGSMMLTAQLLGPHTKETQFGASPVDFDLVVGSGRSQYASLTFDDLMAVAPWLNVTKWIEGPGLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCN2</accession>
    <name>A0A401GCN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610833.1">
        <property type="nucleotide sequence ID" value="XM_027755032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCN2"/>
    <dbReference type="GeneID" id="38776837"/>
    <dbReference type="InParanoid" id="A0A401GCN2"/>
    <dbReference type="OrthoDB" id="3232876at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="398" mass="43478" checksum="CCD032ECCB5D3A1F" modified="2019-05-08" version="1">MEDIRHLSREDPSPFILQRASDSPSRSSSSRIGDLRRSTGNATGPYKECPSTQQQQRFAPMSHSVPPSPDMLAAHGIKVRDFAYESTLPPIKSVPYIPLQVQPGIGGPTLLKRFRISREEDLVDNEPYVRRMFCTDSDAMPGEREQTYEVKKPQPLQRVDTEPVLSEPQSKRAMAFAVLPVGPSHDSYRPPPSTPPRPPSLHISTQSPNRIGPQYFPSLFQPGLQDPSQDSEAWIDTPLVTPNGSLQLPVADNSAIPASQLDTNSQLPAPELFSYSQLGFSPERSQIPASQAEASQGPVNSPPYRIVAPQTSFVADNATVPTTPPSGPAPATPRMSPMDVDGDDDNLSGIQPSRYQLRSRTRQSPHRGRVTKNSPPTSRKGRSSGSRPPGQKRSKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDR8</accession>
    <name>A0A401GDR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0215000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611194.1">
        <property type="nucleotide sequence ID" value="XM_027755393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDR8"/>
    <dbReference type="GeneID" id="38777198"/>
    <dbReference type="InParanoid" id="A0A401GDR8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="130" mass="14900" checksum="C52AD402335B0A16" modified="2019-05-08" version="1">MRARTFLSDDAGDREPQAEVEVEVSPQKHDGDALRWTRNHADRQKQAAYDPLYGSQQFRDGAGDREPQAEVEVEMSPRKHDGDALRWTRNHGDRQKQAAYDPLYGSQAVSSPHDGRMEGFWLWVSLPRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE11</accession>
    <name>A0A401GE11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0301370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611335.1">
        <property type="nucleotide sequence ID" value="XM_027755534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE11"/>
    <dbReference type="FunCoup" id="A0A401GE11">
        <property type="interactions" value="810"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GE11"/>
    <dbReference type="GeneID" id="38777339"/>
    <dbReference type="InParanoid" id="A0A401GE11"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="241"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE80422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="590" mass="67101" checksum="98EDEABA99AD3CB6" modified="2019-05-08" version="1">MATESTGSHKDPVTGEMISKQELKRREKQREKEAKKAEKAAAQPQKPAAGPKAAAVNEADLNPNQYFEMRSRHVQKLKETQSPNPYPHKFNVSISISEYIEKYGPEGKIKPGEKLTGAVECLAGRLHNMRENSKNLRFYDLHSEGKKVQIMATKQDAKDPEGFATLHDNFRRGDIVGVIGTPSRTKLGELSIVPSETFLLAPNLHQLPSGHFGLKDQETRYRKRYLDLILSEDTRRIFITRSKIINYVRRFFDNLGFLEVETPMTSMIAGGATAKPFITHHNDLNLDLYLRVAPELYLKQLVVGGLDRVYEIGRVFRNEGIDLTHNPEFTICEFYMAYADMYDLMDLTESLLEGMVRYLTGGKTTLQFHPEGKGSSKVYELEFKRPWKRYDMIETLEEKLGVKFPPGETLHTDEANKFLRDVCQKHNVDCSEPRTNARLLDKLVGEFIEPLCISPTFIVGHPQVMSPLAKWHRSRPGLCERFEGFMCGKEFCNAYTELNDPFEQRLRFEEQVRQKEQGDEEAQGIDETFVDALEHGLPPTGGWGLGIDRLVMFLTNSTNIKEVLLFPAMKPIETATNTTGSVGPETYLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE26</accession>
    <name>A0A401GE26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0300900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611288.1">
        <property type="nucleotide sequence ID" value="XM_027755487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE26"/>
    <dbReference type="STRING" id="139825.A0A401GE26"/>
    <dbReference type="GeneID" id="38777292"/>
    <dbReference type="InParanoid" id="A0A401GE26"/>
    <dbReference type="OrthoDB" id="8025968at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF25">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="5">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="4">
        <location>
            <begin position="271"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="548" mass="62263" checksum="09814BF0A136719A" modified="2019-05-08" version="1">MLLALARSMIYTKDLPCYLWAEAVSHAAYIKNRAPTSVLNHATPEEKWNQSKPNISHLREFGSIVWVLTEDIALSKLAPRANKYIFVGYVDGPNAIKYYDAKMHQIKMTQNYHFTNRDPSPNNTTLQPREREGPDAPQSRTADMQREGESSDSGGDALQSSVNNPLKCRREEDEDRDAPNKNKPRCSKRVTVRPDYRLLNDSDTDAKDNADADTEDNDSALIADLIYVAMSEENMEANEPKSLNDAKNSSEWPKWETAVQAELEQLDNMGTWELVDLPQGRTPVGNKWVLVKKTNREGEVIKFKARLVTKGYSQIPRMDYTETYSPVVCLETIRAILGLAAILNWDIQQMNVKGAYLNGILKEEIYMRQPKGFSNGTHRVCRMRKTLYGLKQAGHEWNIILNHKLLDAGFRQLFADPCAYIRTKNGKTEIIAVWVDDLLLFTNDHDLMDHLKKELQSMFEVTDLGEPKKIVGIEIERNREKKTIKVSQNKYIDSILRRHGLENANPVGMPLDPNVTLEKDEDDTNEVPNRDSGYASLIGSLMYAAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE51</accession>
    <name>A0A401GE51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0301650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611363.1">
        <property type="nucleotide sequence ID" value="XM_027755562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE51"/>
    <dbReference type="GeneID" id="38777367"/>
    <dbReference type="InParanoid" id="A0A401GE51"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="7900" checksum="028B3017D09566E4" modified="2019-05-08" version="1">MYFSKSILAAAVLVASGVNAVYVYTTVYVTSTRTIDVQSVTTTPVTSTRTSTITASATSTDVLTSTSVSTITSTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEQ7</accession>
    <name>A0A401GEQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 8 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0303300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611528.1">
        <property type="nucleotide sequence ID" value="XM_027755727.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GEQ7">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEQ7"/>
    <dbReference type="GeneID" id="38777532"/>
    <dbReference type="InParanoid" id="A0A401GEQ7"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="3">
        <location>
            <begin position="797"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="4">
        <location>
            <begin position="1338"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1571" mass="174416" checksum="30B7A14A75277B6A" modified="2019-05-08" version="1">MNGTTVNTNDHSHVASRPSLDFSDTEGEELQEHAGDYSTRFEELMSDGEEESNIHVSDEEEDHGFVYNGVDSEPKGGYREQLRDLLGPDHEEDELDAAEVEHSLVVNNGEHEKLATLMGDEAGVDVPHIEVLSDDSPSTSSLSSPPYGSGLNGSNTPSKIYHPFLHPTISRLRSTTPQASRIPSSRSMGSINSFARDDPSAAPSHFSELSRMSSGDGAESRADRDREVFRWTQLRVVGEYLYAKHPQKASALLGTGNFGSPTVLAANGLICVGTDSGQVLVFDFKQNFQCICGAETPDRSVGSVTALALSFDHTFIAMGHASGHIQLYDLNNPKMPARFVAPTTLAEVVSGRQEGHLLGSRIVNVGFIAGKHTAFVSSDDHGLAFYHRLGKVLFVDAIDVLRILGKYPDIESSVPPAPASGPHFFRRRKSRVTSTILAMGPLPLGTSSHPTDQYNLIALLTPIKLVIVGLKPTPKTWYRRHRESDEEVMSKSKFKGALAWYPSVTAGNAVTIEQESKRSKPNGVDHGPSTMPMLVYSWGDTLNLMRVSETKAVQQIRNSRTGKVQNIEVGRVVFEESSRWTAGGDVLSLQWLNVNQVVVLTPSALEVYDVRTLKLVEHVPYNAWSLVSPILSHTTNGAVSYSDAITEVAHSVRVYKGKIFILAQHEVQVGTLLTWADRILSYVESGDFLSAIDLTRSYYLGDAPGNRNGLPDTAVKLKEVVGEKMRELMVASAHYAFSEDRMTDGTHVTPDGRGVDRTFLFEGLVATCTRACIALDDFDFLFEDLFQYYDSNAIARIFLAQLEPFILEGTVRHVPPRITQRLIGLHDDDHRPDLAERVIWHIDPDCLDINQAITLCQNYRLYDALMYVYTRALKDYVSPVVELLSLIRQVQQYRKAHREGSPPAAYADEEAIEPIVLNAYKIYPYLADVLSGLTYPSEEPLPEEEAFQAKNDIYTFLFFGRSSMWPPGEGGRLILTSDEENGVEPTYPYTRILLRFDPEAFLHTLDLAFEDAYFNDKTRRVSRLVIVKILLEITNSSGLSPAEFTFVNIFLARNIPKYVQFIEIPPSALHTILIGLAEDPDHSTREDRQLAAEYLLSAYTPHESDRIMVLFEQAGFYRILRTWYRQERQWSSLLLSYLDDPDMSPTNVFPSVNEVLDVALRSNKGALPKELGATVTDSLGSLLHASVVSTAALLDKYMPALHERALEALGLDAEHEHFAYLRYLLGSPQTGEEYGIESRKGGPSLNLLPRLRQLYISLLCRLESTGVIEALTYLPSDFLDATEMMQTCEKHEVYDAVVWILNRNGDPQSALTKAEAFDRVLSTRVADQLTSSLVEAETAIHTSLSALESIGRTTVSICLERSKPTSSVEVPLEDIWFQLLRSQIDSVQRVASCCSPEALNPASEDPTREMALQQQTLTSLRSLVQRTFGSLMSISSTKAVSFPRLFRRLVESASASHVSKHTLYAEFRTILTGMLDSFRSEGDLLIITKRLVDRDLFATIEELTQDRLQGWAPSQGTCRSCGEVFLNAKKTSTSGESDFGSAVPIIVSRTGAIYHSQCLPPDFPTNTSIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF94</accession>
    <name>A0A401GF94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611771.1">
        <property type="nucleotide sequence ID" value="XM_027755970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF94"/>
    <dbReference type="GeneID" id="38777775"/>
    <dbReference type="InParanoid" id="A0A401GF94"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15044" checksum="9797394E2992EDD2" modified="2019-05-08" version="1">MAETPRKAFELDRPKAPSDDSSRRGPIDSSTAVAATKATLTSPGVPPAQVDPPMTKPGNVTRTITLDLGFKQVGCTVDRPKRAFDKASKASPKSSPAMTFITGGCADAKHFEEDVDMMQRRVDKIAPISQSGETSAQPTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFA6</accession>
    <name>A0A401GFA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glutaryl-CoA dehydrogenase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0305880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611781.1">
        <property type="nucleotide sequence ID" value="XM_027755980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFA6"/>
    <dbReference type="STRING" id="139825.A0A401GFA6"/>
    <dbReference type="GeneID" id="38777785"/>
    <dbReference type="InParanoid" id="A0A401GFA6"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="11">
        <location>
            <begin position="77"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="10">
        <location>
            <begin position="181"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE80868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="36081" checksum="EFB9419DD9DA17EA" modified="2019-05-08" version="1">MGKLGFLGPTIQGYGCAGVSSVAYGLIAREVERVDSGYRSTSSVQSSLVMHPINEYGSDAQKEKYLPRLAKGELIGCFGLTEPNHGSDPAGMETTADQVDGGFVLNGAKTWISNAPVADVFVIWARCKWDDKVRGFLLEKGTKGLTAPAIKHKLALRCSLTGSIFLDSVEVGHDALLPKAKGLGAPFGCLNNARYGISWGAIGALEDCINRTRAYALERHQFNRPLASFQLVQKKLVDAQTEAVLGLHASLQVGRLKDAGKLAPEMISVVKRNNCGKALEHARKVLDILGGNACSDEYHVGRHVANLQVVNTYEGTYDIHTLILGKAMTGIQAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFA9</accession>
    <name>A0A401GFA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0306040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611797.1">
        <property type="nucleotide sequence ID" value="XM_027755996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFA9"/>
    <dbReference type="STRING" id="139825.A0A401GFA9"/>
    <dbReference type="GeneID" id="38777801"/>
    <dbReference type="InParanoid" id="A0A401GFA9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="9686" checksum="D2B48A89D197C0FE" modified="2019-05-08" version="1">MAVGPSLRTLPMEHRGGGPIAQNTTYGGGPIAQNTTYGGGPIAQNTTYGGGPIAQNTTYGGGPIAQNTTYGGGPIAQNTTYGGGPIAQNTTYGGGPMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFW8</accession>
    <name>A0A401GFW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0307830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611972.1">
        <property type="nucleotide sequence ID" value="XM_027756171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFW8"/>
    <dbReference type="GeneID" id="38777976"/>
    <dbReference type="InParanoid" id="A0A401GFW8"/>
    <dbReference type="OrthoDB" id="2574468at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="17747" checksum="8CBE244682F0C53A" modified="2019-05-08" version="1">MALKRKLELEAVDAPISVKQPRLIPFPNTEMDTDVVMSDGSISDLEPLYLPVHSRLPSNASCSSLSSASDSPQDSPIYPAFDLYPHDAYSYMDANFHVHSPSNVMQKSVGLLQPKNAALTHHGQNCSQIPKLRIACSPGLNGQRTMWAFCEQCGAIEMVDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG18</accession>
    <name>A0A401GG18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0308600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612047.1">
        <property type="nucleotide sequence ID" value="XM_027756246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG18"/>
    <dbReference type="STRING" id="139825.A0A401GG18"/>
    <dbReference type="GeneID" id="38778051"/>
    <dbReference type="InParanoid" id="A0A401GG18"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="74"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="226"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="560" mass="60946" checksum="8D22F551E778122F" modified="2019-05-08" version="1">MVHWKDLVAEKRLRQEDSIPKEWLISVPPDSVLDVRNVPQECGRLSARELDITNTVDVAVLLKKLATAEWSSVEVTTAFYKRAIIAQQLVNCLTEVFVDRALARAAELDAHLKSTGKVVGPLHGLPISLKDQICIKGLETVMGYVSWIGKYAERDAVLVEILSENGAVPFVRTNVPQTLMWTETFNHVFGRTVNPANRSLTCGGSSGGEGALIAMRGSSLGVGSDIGGSIRIPSVFNGLFGLRPLYGRVPYEGCVNSMLGQDSIPSVLGPLSNSISGVKVFMQAVINSRPWLRDPLAVRKKWDEDAYALAEHGGGQELCFGIMWNDGIVVPHPPVIRALETTKQALLAAGHKVIDWEPYKHSELGACISAIWNAGAAEDYKVVTALTGEPVISSMSPDEDAGPVSSSFRPADDGLSAYQLWQVQSRRAILRKEHLDHWAKTLEQTGTGRPVDAIICPAAPYAAPPHGKNLSASYTKVWNTLDYPACIFPVTKVDHVLDVKKPAHEFLSEEDQRNYEFYDPATFKNAPIGLQLVGHTLEEEVVIAMTEIVDAALKSAAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH25</accession>
    <name>A0A401GH25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612400.1">
        <property type="nucleotide sequence ID" value="XM_027756599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH25"/>
    <dbReference type="STRING" id="139825.A0A401GH25"/>
    <dbReference type="GeneID" id="38778404"/>
    <dbReference type="InParanoid" id="A0A401GH25"/>
    <dbReference type="OrthoDB" id="3269282at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="451" mass="48888" checksum="E81271D39C08AF04" modified="2019-05-08" version="1">MSSPPSSLSSSLSPSSPLTSLSVGSYPGALPELRVRFDEECVLIPEPISPSRMPRLVRKSYSLPLWKRKSPDSVLSSSPEMEDEHVVFTVSVPSFTTKSRSPTRSEALLQPLVPCIVDHASPKSPELRGRHARNPSSPPLSPRADIETVPLLPCCHECFHITDECLKEGEQWEEKFTRGARRLHNSSVDACPASHSHHRVAEAMPGFDDIVAVDEVDKKRLSHDLESHPALTKVDSLDLHRNDQLRLLPSLSREKSPPQIVGRSDMIPTPLQKVAEEDSDPLPLSKPTISTPSVSSQTCIVTPHTTDIGALYDTMVADSTSPHTEPSTPSTSSATPSVSHSAPLTTPDLHLSLIPSAPIPIPTSHHAHPHPHQRLSPHSPSLSRGSLPHSADLPVPHSLEYFASPHTPHTPRTPKRKRSLTHVLGPSSLLRVSAELLKGVNAVSGSPPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH73</accession>
    <name>A0A401GH73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612432.1">
        <property type="nucleotide sequence ID" value="XM_027756631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH73"/>
    <dbReference type="STRING" id="139825.A0A401GH73"/>
    <dbReference type="GeneID" id="38778436"/>
    <dbReference type="InParanoid" id="A0A401GH73"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="395" mass="43269" checksum="7064571C8355682A" modified="2019-05-08" version="1">MGKSPAMSQPSSVLTADKDGWYRPAVNTDAGVQSTFMALRNDLAEEFTVERMLCPHPTIPRSFIDSREGLAASTHMDEVQPAPLQVDKAQGTPPGLDGSVPQLGSVSPKSLPLLAPTHHIEPRQPTPPPVNIGGMAKESLAPALTVEVTAMQQLVEFIGLTVDQSVQKALSNFTPVLECQNEIIRQLAPLATLLPSVRASTSAKNEGRSTVSHSMPNGEYDGREEDNDDCDDALISRVKHSRGECDNVFHDCFREYLKVKGLLPKARDSPLSPVPKPEIMQAWHDGEGDGPDVAAPLIEWSLPLSSAWNKEVIHIVTEEFLKQVAGGEHPPLVSDPAWTITTASQCCLCKLQNGPHKRFTEVELMEDEEVESARNTAKKQHRKNSRRETIRHLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHA9</accession>
    <name>A0A401GHA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Caleosin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0313060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612490.1">
        <property type="nucleotide sequence ID" value="XM_027756689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHA9"/>
    <dbReference type="STRING" id="139825.A0A401GHA9"/>
    <dbReference type="GeneID" id="38778494"/>
    <dbReference type="InParanoid" id="A0A401GHA9"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27296" checksum="B76EACC91EC0E6CA" modified="2019-05-08" version="1">MQQQNTAVQTAIPAQPVTVERPLYNPVNSGKLVNPGTGRANLAATADQPRGTQSNKWASDHSKQTVLQQHCDFFDPDNDSIVWPLDTYRGFHDLGFNILLSVTAMFIIHASFSYATVPGYLPDPFFRLHLKNIHKAKHGSDSGIFDNEGRFIPQKFEDFFSKYADGKDGLTMEDVLKALKGQRLLMDFTGWIGAFFEWLSIYIFLWPEDGMMKKEDIRRVLDGSIFSEAASKRAGRKKTKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHQ1</accession>
    <name>A0A401GHQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0400870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612629.1">
        <property type="nucleotide sequence ID" value="XM_027756828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHQ1"/>
    <dbReference type="STRING" id="139825.A0A401GHQ1"/>
    <dbReference type="GeneID" id="38778633"/>
    <dbReference type="InParanoid" id="A0A401GHQ1"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="611" mass="65093" checksum="4F3C12BAD0637770" modified="2019-05-08" version="1">MLATQIPFHAQPTLPRDVLARSRVPSESRLSRLQQFIAQKSPTLGALTSRVPKGLGLSGFENHIQYDNSVIRTGYPNVGISQPEFLEASMPPTYPEQFQFPGSIATGALPPQATPSGKRIGWIRSLVPERLRTPQACERCRERKTKCTGTRPTCKRCLKSGAVCVYVLDHKNNRIKAKKTKLRGAEAYAYSVPDAVYGYAGEPMPSMSEIMSAQAALPLVHDAYNLSQVSPYSFPQAAAPSLEVHGAALPQPPAPAYFDVNPFEAGFSRSSSGPALGQAGAGRTQWSRPGYSRHSSSNSSSRSRHNSSSRSQQGSSRPRSTWTMKPSSAWGSSPSFVLLEAERSVSNGSNGPVECLTFAPSSANAGQNAVVVSETQAVSSLQVPDASREFLSSSSSVQGASPTAFDELEAERALAEELERELAAIGVDDGDQDALFLPIPSNLSALSSNGTTSGMDLLAVPPWSYACAQPNAGMLNAGVSLIAQPHAESNPDGFLGPIFQPDQELPMDRDFFPTAPSFTSSEASIPSESATIPQGPLPGFMEAALQECMAKFPMPVIALDVDYLHPDGWMLPAEAQTDCSEASNTGTAAEIPPSNSLKALWVEIFGSEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHV9</accession>
    <name>A0A401GHV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0400840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612626.1">
        <property type="nucleotide sequence ID" value="XM_027756825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHV9"/>
    <dbReference type="STRING" id="139825.A0A401GHV9"/>
    <dbReference type="GeneID" id="38778630"/>
    <dbReference type="InParanoid" id="A0A401GHV9"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="91"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="500" mass="55995" checksum="B85D493F0F57F2CB" modified="2019-05-08" version="1">MSHTPSGRSTPLSFRGVVHDVMKHYKHEKESEAHRIFRDSAGHKPKGILPQTINPDEETVPGIRHPGSTGVIYCSDRAMANGFSYASSHKWANLGQGAPEVGPIPDAPPKPQSIPIPEDSLEYAPTTGVKALREAVSNLYNQTYRRGKLSQYTYENVCIVPGGRSGLSRVAAVIGNVYCSYQVPDYTAYDQVLSAFRRLVPVPTALEADNDYRLDLAQTRKDIKTQGLEVIIASNPRNPTGQVIRDDDLKALVDLSREAGTTLILDEFYSWYIYPEKDEDYGKSVSSAAYIDDVNQDPVVIVDGLTKNWRLPGWRVCWVLGPKNLITALSQAGSFLDGGANHPLQLAAIPLLEPSRVEQEKLALQRHFKMKRDHVLKRLEQLGLKVKCPPKATFYIWLDLEDLPAPLNNGLTFFEELLKEKTIVIPGIFFDINPAHRRNLFNSSCHHFVRLSFGPPLKDLDMGLAAIERIVRKAKREGMHVFGHNYKQSAKKSIHLERMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI02</accession>
    <name>A0A401GI02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612648.1">
        <property type="nucleotide sequence ID" value="XM_027756847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI02"/>
    <dbReference type="GeneID" id="38778652"/>
    <dbReference type="InParanoid" id="A0A401GI02"/>
    <dbReference type="OrthoDB" id="3235609at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="176" mass="19642" checksum="2A8BF3ADC7DE23E3" modified="2019-05-08" version="1">MRGHDSRDFRSRSPRRDTNRDSRPRPRSPQPSLHQPSVYVIDVHLMHEKLKQAILPSANIPNNAHDLSVQGRSDVNDPAQQGWCAGNESGLLGRMWYSMARGPTIDEQRLCRWVMPVINSAGDVQDPPQAPNEVNCDDEDDEIDPNDMVGPKEQGSAPGPSATSDIYANMSDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIS5</accession>
    <name>A0A401GIS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0404840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613017.1">
        <property type="nucleotide sequence ID" value="XM_027757216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIS5"/>
    <dbReference type="FunCoup" id="A0A401GIS5">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="GeneID" id="38779021"/>
    <dbReference type="InParanoid" id="A0A401GIS5"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="74765" checksum="2E24F717549A095D" modified="2019-05-08" version="1">MSRSKDNSRLRVPGASKSSSRPGSRLRTSRNPSLSSLSYIPFGPEELINPDAPVSEEVAELLQEFVHPHRHESEQTLVQEAADEVCADDEIDTAKQPLDLPWWKRPSPWWFLVLIIISSVAAGATMAPRVSVYTRLACDTYKPEYSRVGRNPDNLTLLSPHANNMSSVVPSGGMASTPPSDRDWALCASDPVVQAAVAKLSLVIAASTGILGCITTTMWASLSDRYGRVRIAGISTIGILVTELGFLLVYNFPNSVPGGIWFLVLGPIIDGLLGGIGAVSSAIHAYLTDCTEPSSRSRIFSLFMGLLFAGISIGPTLGSLTINLTGNIISVFYISFCTYLILCLFLWVVIPESLTKAQRAEARRLHAEDSARLAIARSKGGLLTWLGRPFDFLRPLALFYPMVIDDSASKKRRDWSLLLLVAGCGCTGSLIGGLTYKMQYMSSVFGWTAAEIGYWSSSVGASRAIHLTLVLPLLTKLFQPKPSAIMLPIEPLEPLRPETASSESLAPQETAPPPHQPHSPHFDLVIARCSLLLEISSYILMAFTRTGGLFTFFGIMSSLGAGYGPAISSVASTLYATRGGKEMGKLFGAMSVIQTLSSQVLGPTIFAFTYMATVAIFPPAIFFVSAGVLSVAFILFLFIRLPKMPQEASDVDVEDPLANHPTLRREETLTDVEEVLIVVDDEDRGKKVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ01</accession>
    <name>A0A401GJ01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Exosome complex component mtr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0405360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613069.1">
        <property type="nucleotide sequence ID" value="XM_027757268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ01"/>
    <dbReference type="FunCoup" id="A0A401GJ01">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ01"/>
    <dbReference type="GeneID" id="38779073"/>
    <dbReference type="InParanoid" id="A0A401GJ01"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="47"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE82156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="261" mass="27958" checksum="AE8BA0F7D219999C" modified="2019-05-08" version="1">MALSNFDRRRINGPEESFSPVFASDEEDESLLVTPGKSRQGRSAGDIRPVFLEAGLINQANGSAYIETERTKIACGVYGPRQSKTTVYSEQGRLNVEVKFTPFSCTRRRVPIHDAEDRSVAVQIYQALLPAVRLELLPKSTIDVYITIIENDGIEGCIAAGSVAASAALADAGIEMLGLVVSCAASAIGKEIWLDPTEVEAEAASGSLILAGMPALDTITSIWQSGRLTSAEIVKCMEACQERCEDIHAVVAQGLLLNAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJN2</accession>
    <name>A0A401GJN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0407620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613291.1">
        <property type="nucleotide sequence ID" value="XM_027757490.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GJN2">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJN2"/>
    <dbReference type="GeneID" id="38779295"/>
    <dbReference type="InParanoid" id="A0A401GJN2"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="564"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1477"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1478"/>
            <end position="1496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1496" mass="165987" checksum="7B84238012A4DFDD" modified="2019-05-08" version="1">MDSSSPGQSAAQASESVSSKHILLSEILTVTSVMRKNSRWASSMHSFSTRDSALASSLGLRRTKHFLDRDVSERGSTEQELMTGFQELKRLVKDVDDVRSLTLATLLAPFFAIIRSPLSTGPITSAALSSIHNFFVCNLISPTCDTLPNSLGEMSNAISRCKFETSDSSGDEVVLLKILTVIQDAMCGVVGDALGDIEVCEMLETVLTTCCQTRLSEVLRRSAEATMHSLVRTVLSRLQVLDLDVEERKLSDSGCDAVEGEVKMSVSTKSLAEHNSGNVDTEDDARTAETAVDQEVPTASAIKAERQEYGLPSIVELLRVVINILDPNDQAHTDSIRLTALRIVNVAFEVSGSRICEYPSLSTLVLDHGCKYLFQLARSDNPSVLQTALRTISTMFETMRPKLKLQQELFLAFTIDRLAPPMPKGIPALGGKGLSASSRPGTPNLGSELENGPSTPRILVAPARGDTRESLLETLSLISRHPSFMVDLYTNYDCDMNCENMFERLIEFSTKGVYPPQSVGGLEFQQQNSQYLCLDLLLAFVTHMASRAEGLSETWPVNFVSPEDLLLTKSRKKLILTGTARFNTKPKTGLSFLEENRLIYTDPNEPRTVSLAQFLKNSARVDKRLLGDFISKPDNIEVLKAFMLLFDLKDKPVAEAMRELLEAFRLPGEAQQINRITETFAEVYFATQPAEVKSQDAVYVLAYSIIMLNTDLHNPQVRKRMTIEDYTRNLKGVNDGSDFSAEFLQNVYDSIRKREIVMPEEHTGQLGFEYAWKELLTRSRQTGEYMMCNTSLFDVEMFRTVWKPVVSAIAYAFITFEDDYIIERAIAGFRQCATLARHFGMPDVFDYVVVSLSQATSLFSEAQSPQVPNYPVVEVEGQSITVSALSVKFGTNFKGQLATVVLFNIVNGNGNALREGWTQIFEMFQSLFLHSLLPAKMLQMEDFLGGTSIIPLHGSQPSRHAPRSDGLLSALSSYLMTPYSSSADTLVPDATDSDIENTLCTIDCISSCRLDELYGQILQLDVDALVAAVRALEALAHERTVARLKQESDDVSLGYSTPQGGLYSLPYDPASVFLLETMVSIVCQTPQHIEDLWPVLFEHLSALLSAPTQYSILLIERAVVGLLRICLILATKVALRDQVYVSFDLLASLPPSIATAVAEQVVAGLVRIAKHHGDIVNSQTEWNIVFALMRSTIAHPEASRQSFQLITSLVSQGPEQRVTMDNFTGLIGVLEEFSAVASTAVEAQQQGRRTQSLNTSNSPIVERGRKAIDMIADLKKFWSVFSASAVRQKGLVWRQYCLPLLSALGRQSTNVSREIRQAAMVHLQRIVLGPHLPVDVNEHGQVEELFNRVVFPLLDELLKPQVFLRDPMSMPETRVRASALLCKAFMQFEAREGQKADIRVMWIQVLDLLDRYMNVDRRGQLYEAVPESLKNVLLVMNASGLLVPPSDPDERDDPQKALWLATHERIERFCPGFLFDVLPPPPPPQPTPVPHLSPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJP9</accession>
    <name>A0A401GJP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0407690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613298.1">
        <property type="nucleotide sequence ID" value="XM_027757497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJP9"/>
    <dbReference type="STRING" id="139825.A0A401GJP9"/>
    <dbReference type="GeneID" id="38779302"/>
    <dbReference type="InParanoid" id="A0A401GJP9"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF5">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="57"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="37192" checksum="DDF7D223EFA19DFC" modified="2019-05-08" version="1">MDSPSQSGAEIPTIFDPTTCTRKGLCPVTLIRKQGEPFESHSLYFEQHGSGPEKIAFIMGLNSSSFSWYAQVQHFGRKPEYSILVFDNRGVGNSGTPRGPYTTSGMAEDVIVLLDYVGWTDKRDLHVVGASLGGMIAQELVTRIPDRVVSLTLAVTRASGRSLSSLPTPKGVITLARLLAIKDPEVKIPMILDMLYPREYLDAPAPNDPEGRTNEEIQTAGYRRRIAATRPQKLMGALSQMVAPMTHHVSPERLRNISATIPKVLILTGDQDNLVNPAHSLYLKEHMPEAELVVWEGTGHGILGQHTDRLNELFERVFREGRERLAEQQQDATENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK58</accession>
    <name>A0A401GK58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0409260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613455.1">
        <property type="nucleotide sequence ID" value="XM_027757654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK58"/>
    <dbReference type="STRING" id="139825.A0A401GK58"/>
    <dbReference type="GeneID" id="38779459"/>
    <dbReference type="InParanoid" id="A0A401GK58"/>
    <dbReference type="OrthoDB" id="4501419at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="267" mass="30133" checksum="5D7D11C60EA85654" modified="2019-05-08" version="1">MRPIVVADIQSSISLKRPVLFLDANQLSCRWLFIAAFRGHITSLGGIAFPEEIWRYIQSEIEFSEPEWVAVRPDPGVVDVAESLVAIRCTEIALSEIVDIIKNADDVHTYEKLFADTTDESMQSDFLSIGDRPLRTFTVTYQLPFASGGEQIAPPNLTPCLFTDITIPDYISRIQRGKCWVCGGGRTICPGCTEVPDKFDAFMGCGVALACPLCMGLDFCWEDKTFWQTYYRKKPPKEEKISHDRRVNRRRAELGYPPYSEEVTESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK82</accession>
    <name>A0A401GK82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0409540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613483.1">
        <property type="nucleotide sequence ID" value="XM_027757682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK82"/>
    <dbReference type="STRING" id="139825.A0A401GK82"/>
    <dbReference type="GeneID" id="38779487"/>
    <dbReference type="InParanoid" id="A0A401GK82"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="372" mass="40197" checksum="BD5D2A5335C1A20E" modified="2019-05-08" version="1">MDVRHAHGTDVHVVRACYHEDGTDLVAVGGNHTVEVLLTTPTTCEVIASFHIGTRITALAWSSNVTSPSVSDEWSFELAAAGADFGLFLLSKTVGSEEDVFPFGGGLSGHHGKVNDMAFCGGRTEDSSRYVATVSDDKMLMVWDLDPSIVIASPPLPEVDEQSGLLNRPQPTAYVVAFPHPLTTVNSHPTTSKEFLVSDCRGSIFLTDWRSDPDEGEQGGWRSSVLELVEPRALSDSVTGLATKWSGSVSWRRDSADVVGAAYGSKFAIWDMANLQGGKPSVSGASFTEGGNHFRWCPTYHEYFAISAAPPTKGAVIHLYNTGYIQAQPTVYNIGSRPLYVRTFDFMADRGIPRIVAGVGREVVIFYIGDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKE6</accession>
    <name>A0A401GKE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613549.1">
        <property type="nucleotide sequence ID" value="XM_027757748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKE6"/>
    <dbReference type="GeneID" id="38779553"/>
    <dbReference type="InParanoid" id="A0A401GKE6"/>
    <dbReference type="OrthoDB" id="21330at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="226" mass="24983" checksum="7035C7356FD171C2" modified="2019-05-08" version="1">MQAFRGFSRVCHRQLCYDLARRSLSTASGPSEPNVSVPWFMDPSEVSNPPTASSVHRPTPPHLRPSSLEPLAPLPATIPADSHIVHLHAALRTSPHLEPGTLLVREPVPTSVGPPLPDAMPKGRRKRGRTYAGEPVYDYDGGIWNWVVIAQVKEGTENRGAIESVVRVVRKVLLTAQPPVLLPHNTKKRMSDGWAMLDAGDFAVHIVSKDAREKFFPDSRREWSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLE1</accession>
    <name>A0A401GLE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613898.1">
        <property type="nucleotide sequence ID" value="XM_027758097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLE1"/>
    <dbReference type="STRING" id="139825.A0A401GLE1"/>
    <dbReference type="GeneID" id="38779902"/>
    <dbReference type="InParanoid" id="A0A401GLE1"/>
    <dbReference type="OrthoDB" id="2803957at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="298" mass="33308" checksum="0E61C9D3C8130DB5" modified="2019-05-08" version="1">MIATFNSMDKDEREELIYTFEAIITFIPGLKDQLAYMGEDIDAVDILGSYLNHYATDARDDHLGSLRERIINYIPDFGDGYPTLKPQDSKWKRGFQSTTTGCLLCPQSMLSDFLAEPDGFCRQVCDGEIDVASDEFPSFLYDQDLYDPDELDAGLLKGPVLLSCFKSLITGPGSASSNRGDREGGSSRPGRPPLAKKYDMTHVSPRSIAYVAVLVRFLLNSQHSWSNIDVNFNLEEFFFEILRLFQDEEWGEATLDWWNKSVFGTPAKSAKKKTRPQSAIAKLKAQRAARAAAQSGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLJ3</accession>
    <name>A0A401GLJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0500890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613958.1">
        <property type="nucleotide sequence ID" value="XM_027758157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLJ3"/>
    <dbReference type="STRING" id="139825.A0A401GLJ3"/>
    <dbReference type="GeneID" id="38779962"/>
    <dbReference type="InParanoid" id="A0A401GLJ3"/>
    <dbReference type="OrthoDB" id="3259324at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="54766" checksum="470A9EC8DDB4B931" modified="2019-05-08" version="1">MSGSPRSSTSAESLSSGRRSPIGGFDSSAALILEPDVEDTTESHPFDFTSDDETDDDLTEQTDRLLSSSVPPLSSLTVFLYLLSPFLKLGAFLVPDAGLPLRYGIPVLLFFAGLSALTRQIWYMLARYVRRADLEEIVLQTFARDRRKEGTRWLLRQLVRFGVGLLRVLIAALYLRAAVDVLLPLVPATLVIPPRVLLTIILAAVICPICFAPSLGATSVLYASWISVTAYAAWFACTAYAHAKGMLVVNPGSASLGILWEGSSIIAFAFSTSSTIPLYAALKGTIQAAQDRPRRSQSFKLLSVLSIGLAALCIFPLVFFQSPANSPTLPTATLKILTALSNAVALALSLPAVLISSPPLPIPFSIRHATNFPLSRSLLYAIILCLSLLPRSLSGVLSDFLLVLAFLSTYMLPAFIHITLHNFREPLSIIIPPSTPVTAASPFTPEPSSAMSDSRHDELLQRKERTLQRRRLGKRIIWDLGVWLLLVPVSGGGLVWAAGRIVGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLX6</accession>
    <name>A0A401GLX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0502170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614083.1">
        <property type="nucleotide sequence ID" value="XM_027758282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLX6"/>
    <dbReference type="STRING" id="139825.A0A401GLX6"/>
    <dbReference type="GeneID" id="38780087"/>
    <dbReference type="InParanoid" id="A0A401GLX6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="119" mass="12895" checksum="480B38F84C5BFD08" modified="2019-05-08" version="1">MAIAPDGDAVIADGNAITPDSDVIARDGDATDKEKEEEEEEEEEEEEDDDDVIAQTPSRKRVVVSTSTHVDDDGELLDPDNISMRALKHSAVQTAVAHGEHTVNTHLSVMLPELNSHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM95</accession>
    <name>A0A401GM95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0503850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614250.1">
        <property type="nucleotide sequence ID" value="XM_027758449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM95"/>
    <dbReference type="GeneID" id="38780254"/>
    <dbReference type="InParanoid" id="A0A401GM95"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="48"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="49000" checksum="53A565132414E2D6" modified="2019-05-08" version="1">MHAPMQTTLRFPDSASVERMPSGLIQARRVGSSSIGDPVTFIDGEFGGHTLRAELIELQKADLGRKYARKDRRPLDPPPVVQFRLFEVYNAGTPREIEKEFENYDDIKSLGLLCHVDLFPVPGDDDADVPQVESSRLRPEEQYESPSAPSSSTMSTSLLHPSSFPGISAQVNRGFSSMPPSLSSSYTVPPPLPPPSMSHELYPGSAQVSAGTMPNMFPMSTLTPASWTHSYSIPAPPPPPGLNQNTLMPSNVGYMSSPPGSRYLHPSTSFVDSDVVAYYGDYAIAESSSCTEALVGATFVQSASLEYKGKKALMFVFSDLAVKIEGTFILRYRVFNIFSKAYGAQEIPVLAECYGGPFKIYSTKEFPGLRASTDLTKHISFFGVRLNLRENERKRRKKNDLVAEPVHSPVSNSSASPAMAATSRGHKERRHSKSSNSEDGGTGRVFEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN20</accession>
    <name>A0A401GN20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0506250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614483.1">
        <property type="nucleotide sequence ID" value="XM_027758682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN20"/>
    <dbReference type="STRING" id="139825.A0A401GN20"/>
    <dbReference type="GeneID" id="38780487"/>
    <dbReference type="InParanoid" id="A0A401GN20"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="95"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE83570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="499" mass="56617" checksum="1B2DB6547B7D3715" modified="2019-05-08" version="1">MLRGRFLSLVHRSHRSSLNKPAWRSKQALCCRAPRRRIHTAPSTSASTSDAQGTPASAEHTTVQFYEEPFALDVHQGFGYAKINIGDRLGPNDRLEILHKLGWGMYATAWLVKDYEQNRYLAMKILTTYGTHLERGEVKEHPHMHEADIMRAVSRQTSSPGAQHCIQLVDAFYITRETGNHLCLLTEVAGMSLDRLQVLITTDGGFPTDLVKLFVKQICLALNYLHTECRVVHTDIKCSNLLLSFQPEIRDEVVAAHLKYRPVRRHPVNTVCDIMEETIVSEALPLPGFDEVPPLSWIVKVADFGSAQWLDNRSTDHVQAVGLRAPEVLLGRAWDEKVDIWSLGCMAFELLTGKNLFRAEATRTWAEEEDVLAAHLETHQLTRFPPQFYEGSKHAEQYLNEDGTLRKIPESMIYPKTLARILSVYKVPINLDDPESVRDLAVSFIERCVTLDASERATAAELLQHPWLQRVGEECDSRRLAKRIHFGRDTMTLPNEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN89</accession>
    <name>A0A401GN89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0507170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614575.1">
        <property type="nucleotide sequence ID" value="XM_027758774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN89"/>
    <dbReference type="GeneID" id="38780579"/>
    <dbReference type="InParanoid" id="A0A401GN89"/>
    <dbReference type="OrthoDB" id="3198848at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="188" mass="20801" checksum="E3F0008ADA790209" modified="2019-05-08" version="1">MGKLDSHYDHRNSRPRQAAASRAHTPAPAAPPDIITYRLEGKMVYVTPAETYEEGVTFAKAVFEELSGVHPERITFSVSVNMPGGGRTVQISPMAWRAVVSTLAQYEIVDLVVLPEVVVDFADAELPQYADIDNKESREHLSRSPSPQEKSRPSSRSASRVASRSPSRNPGSPSRTERALNWFEKVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNE3</accession>
    <name>A0A401GNE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0503120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614177.1">
        <property type="nucleotide sequence ID" value="XM_027758376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNE3"/>
    <dbReference type="FunCoup" id="A0A401GNE3">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNE3"/>
    <dbReference type="GeneID" id="38780181"/>
    <dbReference type="InParanoid" id="A0A401GNE3"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="9">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="481" mass="52136" checksum="9928F041DEBB5EA8" modified="2019-05-08" version="1">MSTSKSNAKGRATSAPISGVYKPDSIRDVAESLNITSFSDAVASSLASDVEYRVHQVLEEAARFMRHARRTTLTTSDVDHALRVLNIEPLYGHSPHNPPVFRRAPPFPQLPAAGSVYFVEDEEIDFDRVLREEKLTLPKGVSWTAHWLAVEGVQPLIPENPPAIPKDTDQDFVMAKSTSSPLRPGTVFPPSPPSSDRPSPMHTVTKQQQQLVKHVLSRELQLYYTRLTSALLPPSASDYAKRTAALASLRHDAGLQALLPYLVRWVGEGAVSALKGGVQSETDGRVLEVLLDVIGALLDNSTLFVEPYLHQLLPPILSILLHSALPPSHAAELRTSASQILSHLLTHYSTTYPSLPPRIMKTLLLALISPGKSRGTREGAIRGLMGVGKEAVRKGLVDGGGAKVVGSECFEGESSPVVECALDALKMLHPPSTMSTPLDASSETDVRAVTQLREVLGDFFANKLVDDSEWARGILSADQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP58</accession>
    <name>A0A401GP58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0510550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614909.1">
        <property type="nucleotide sequence ID" value="XM_027759108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP58"/>
    <dbReference type="STRING" id="139825.A0A401GP58"/>
    <dbReference type="GeneID" id="38780913"/>
    <dbReference type="InParanoid" id="A0A401GP58"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="400" mass="43586" checksum="5DDCBA614A2A229B" modified="2019-05-08" version="1">MPLAEGDGMEEAARLAMEAVRAMAFQTGPAAPLQASSSKRMLTPVADEPEDAPEYQAEVAEDERASLEWPHDDRRRSLLMPHEMSAGAAEVAQEVTPSLEISKASKGAKSSTLAKAGHLDEGRRPAKRGAPLDRKAAKKEAEAKRDAKANHLRAVPPTSKAPHLRDVQRVSTESPAPVNEGDTPSGEETSQSSNDDCANCAELRQEFLAHKDGMEVQFQERMADLNTIKAEITAALQRINPPSAFQENARSIREEVKLAMEEFRRPVTIELQESVKLVVADLVAKRHCLPELKEKVNRLEQGANQTVSQADVDKLQGELADLRHSMELQAARSDSMEKELRSSAAEAIAQASKLEMELALAKEDSMVVATSTLDEAKKVGKEVATAREETSLVVKSLDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP63</accession>
    <name>A0A401GP63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614944.1">
        <property type="nucleotide sequence ID" value="XM_027759143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP63"/>
    <dbReference type="GeneID" id="38780948"/>
    <dbReference type="InParanoid" id="A0A401GP63"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8178" checksum="B357213BF3721161" modified="2019-05-08" version="1">MYARGTNTIWVSDEESIAGPAKDGVTALGAHSGDPRPHDTRRTTLQSCLGKHAQSGRSSDRSESEERSRGLTAAGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPU2</accession>
    <name>A0A401GPU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0602140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615149.1">
        <property type="nucleotide sequence ID" value="XM_027759348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPU2"/>
    <dbReference type="STRING" id="139825.A0A401GPU2"/>
    <dbReference type="GeneID" id="38781153"/>
    <dbReference type="InParanoid" id="A0A401GPU2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="177"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="439" mass="50798" checksum="C2749B7594E734A8" modified="2019-05-08" version="1">MLDFNYINPTALPEQYREHLPSQAEWSTERNAHFIGGRPVFIRSDNHNFDYSPEEFERTLPHNFGGIVLQHITDSGITTSYPGERPDAPWNPPAQNPVPQPTLAPIVPDYIPPMATVTMNEGCHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMARNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWREFIASVNKAFGDENIEETTRTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASWFDNQWRSAQIFKRGATMMTRGKGRSVHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDMITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPX8</accession>
    <name>A0A401GPX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0508710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614727.1">
        <property type="nucleotide sequence ID" value="XM_027758926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPX8"/>
    <dbReference type="STRING" id="139825.A0A401GPX8"/>
    <dbReference type="GeneID" id="38780731"/>
    <dbReference type="InParanoid" id="A0A401GPX8"/>
    <dbReference type="OrthoDB" id="2800500at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="693" mass="78451" checksum="B7B6991D4EB4B79A" modified="2019-05-08" version="1">MGLYPGTVKDPHTAFTFAVLDNFLLENKECKTAALNYYSKLKRVTSNAFPGTIPDRYRELMWVSRQWRQLKYHKWHGFSHDALHPVEKGGLAIFCPACPQPGLNLPFDWQADPVQWKFKRGFVMDGNFSAEHMKMKHPKEDVTLSDGQAFMVGQEDYKAHLAVAMESHQRSTCHEHRAVNQANVDCANLNATGIGATACARHGFFVPHTVVDFQKGERQMNMDYSLSNALLTLTGITLILVMYDIMCQYGIHVRKCFRHSAYLRMPFELKVDQGIGLFHVHGHQDCCFQRFSPNFIVGAGMVDGEVIETLWAPTNEVSGSTRGMTRAHRQEVLDDHMNDSNWKKMTRMVPTLMTKWKRVLLGFPRSKESFEALSASTDEDVLEAWQKEYDDAMDARQNDPKIMDTFDVQLMKAPGKDLTQLRLAGEESAKGLEKGTARWLSTGLKIQEAQLKLANDICKAGQNPSMAEDLKTLERRQHLEVSILTFQRRSEKFMGRLEDIPAMEDHDDGALWDFLDENPFQIHPEDAEYGEDAIPPERASLNLPSQIGFVAAVANGLQTLAAQELELRKGLMNDILHELRMALGLKSYLYRKRVRPANSVGTMTRAQAEVHAADQTILACAKLYSTNRRAIMRLGATDEDLALYRPLDKKDLHVKTAVIEASTSGLRNINLAWFWTMDVAGDRGSSEWMDECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ77</accession>
    <name>A0A401GQ77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0602880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615223.1">
        <property type="nucleotide sequence ID" value="XM_027759422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ77"/>
    <dbReference type="STRING" id="139825.A0A401GQ77"/>
    <dbReference type="GeneID" id="38781227"/>
    <dbReference type="InParanoid" id="A0A401GQ77"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="244" mass="26952" checksum="D383D063957C3C30" modified="2019-05-08" version="1">MISLNPGSLCDVCAEEYGPHNYPHSIPCGHVLCLDCCNNILQKTSPRLTPSCPFCRVQFTSDDIRLIRLDFGSSGYATPRTGTIEANHQPADGSDDDILLLNPGLLKTRAEARRLEYKVAKVAAKKCSVEEVTTLHKELQVWLTSDSKPDDQVSSLQLSAALLRAILVNHLAHSEATKHAKSVEANLRQKLEEAESDKTQLEAELRKVVRYLHYHDLAWSLTLFCLASAIFGEGAGMSVPSRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQG3</accession>
    <name>A0A401GQG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615313.1">
        <property type="nucleotide sequence ID" value="XM_027759512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQG3"/>
    <dbReference type="GeneID" id="38781317"/>
    <dbReference type="InParanoid" id="A0A401GQG3"/>
    <dbReference type="OrthoDB" id="3052275at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="430" mass="48532" checksum="FE3F2B4D3C7F49F5" modified="2019-05-08" version="1">MLDLSERVIVDQSKLGYKEACESKVTLSRQAQFERRNALFEEVGIQKWFEDNSIPYDTQPKMKCSGKDYLTASNVSQNQLEQVYNWTFSKGRVGESVPLRHVTRHAVKILIGETSAANSSTIKIPDAWLANRQVQINEASPFRMLRKTLLLYLEYANEEHIKYREGLDEAPTPLFDLSGDRKTGAESILDLSLYDSENVHSSGALSIECAMLKLFGYPGTLKTISEMDVERHIGPILSGIFNIPGCAGLSSTILKYPTILSCFDSYPRPDHACQISAERLPGIKFCRPLVLAGEARRPQSRVPQVEDTPSGSASNSRVKFPRPASQLAWAFQPTLELFIMDLVTKYRNPGGKTWKKEWDPLANAAIPSHMVVFGIVYDTDGIIFYFYSPTYKVSDGKYTSERYCFEHCSLPLLGVTSWRRRGLTICHFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR18</accession>
    <name>A0A401GR18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0606320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615566.1">
        <property type="nucleotide sequence ID" value="XM_027759765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR18"/>
    <dbReference type="GeneID" id="38781570"/>
    <dbReference type="InParanoid" id="A0A401GR18"/>
    <dbReference type="OrthoDB" id="3133286at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28970" checksum="74C09054DACC6EE2" modified="2019-05-08" version="1">MPSSAKIDEILTVAKKAVTIFANRGQPCCLFGSTACWVYGNSALSGSNRTPNDVDLLVISDQYRTAADCERLKQMLIEGDSSFFLRAPSRNQNADYRVLWYKLSSRPEQRERKCKVDILVPGLMSLPRVPVEHITDVVVSPRPGQAHQVALPVMPLVPLLLMKLKGWKDHRDSDQAHMQVKQGDDVNDIARLLRIVKNQGAFGVRHSSLNWLPDEFVAEAHGRVHEFVKRFPALAEKWEQLDFEVRHGGTTTWVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR93</accession>
    <name>A0A401GR93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615660.1">
        <property type="nucleotide sequence ID" value="XM_027759859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR93"/>
    <dbReference type="GeneID" id="38781664"/>
    <dbReference type="InParanoid" id="A0A401GR93"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="130" mass="14356" checksum="C4E5C48472F976BC" modified="2019-05-08" version="1">MPSLAALPDELPIHRPTHWEQVPGLFPDTTQLLPMAVPGETNAASGSQVARLGRSFAQIAAEADSSMDDNEGDSFAVSRHRAMLQERIVRLQHELNLTEDMHVANLNASSTVFQMGYILRDIRGEAYRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRB1</accession>
    <name>A0A401GRB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615680.1">
        <property type="nucleotide sequence ID" value="XM_027759879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRB1"/>
    <dbReference type="GeneID" id="38781684"/>
    <dbReference type="InParanoid" id="A0A401GRB1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="170" mass="18490" checksum="9B899A61D299B1AB" modified="2019-05-08" version="1">MSFYKLLPSIKLYIFSRVFRAKPITALPFDDEDKVVAESQKNAFADVTEILRDASMEDEDAATEVAVPSGLTAEGIQESEEAVISSGSVPDPAVTSPCPCAPRPELIQLSDFPLDTVYDPLFERNEDVPLIGLGLMGLPEHIKDTSTISDSLDSPCASYFTHNRIPGNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRB9</accession>
    <name>A0A401GRB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0602420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615177.1">
        <property type="nucleotide sequence ID" value="XM_027759376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRB9"/>
    <dbReference type="STRING" id="139825.A0A401GRB9"/>
    <dbReference type="GeneID" id="38781181"/>
    <dbReference type="InParanoid" id="A0A401GRB9"/>
    <dbReference type="OrthoDB" id="417125at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="2">
        <location>
            <begin position="110"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="550" mass="60806" checksum="F7C0FEE1E75CFC46" modified="2019-05-08" version="1">MSSNPVSPVFGINSIAEVDALIASGNVPSSATSRLGAFEHRFLEQSDAYRRLLHMKFLYRASSDVDDQYVERRNIHLQDAQNPSLLHLWNYEKAFMEINRNSDNCFGGGRVHNFLDLGCSPGGFSNWLMKSNRRALGAGITLPDEEARFTMPLELSTFGPRYRVVFDNIITLVMRAVVEDRNPIVQTRDDSGDGDDHALSYDLIIAGAFPTLEERKIPWWLRAQLVLAQVFIIMTNLAPGGSCVMTINTKGFAWLVDVIGLLYQSFDCVTASKSGKLHARRSSCYLVCRGFQATEEELLLYTGRLRKTLKQLDDMSIASRVEGQGVDTRLGVDFGPVRIGNPESLSLVFGESEAHFLEMGLDKIILGLFEPLWIIQYNAIRADFKQILKKVYGAPSDAEQNSSTSEDAAQLGSPSSSPPSPSRWRPRRPSIPVSAFPSQPTSAFLGGSSNKSGSPSTPLNGSSSPYTPPNSPYVPKWRPPQRRMSTAGNRTDNREWRKPAEERLDAAAEPQDNVIAPNLFGRKRGHTVSSSVGSVNSVNSAADASVWWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRK9</accession>
    <name>A0A401GRK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615759.1">
        <property type="nucleotide sequence ID" value="XM_027759958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRK9"/>
    <dbReference type="GeneID" id="38781763"/>
    <dbReference type="InParanoid" id="A0A401GRK9"/>
    <dbReference type="OrthoDB" id="3261439at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="82" mass="8983" checksum="DF6A2877AA20DB4C" modified="2019-05-08" version="1">MEAPKPAMTTSTQPQALQMNMSNPPARAEQTECQHKASRIRGGGAGRDCFMGMIEAFLCFECCKDCCECFADIICCPCEMCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS34</accession>
    <name>A0A401GS34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0701530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 3">Prevacuolar compartment membrane</location>
            <topology evidence="1 3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615882.1">
        <property type="nucleotide sequence ID" value="XM_027760081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS34"/>
    <dbReference type="FunCoup" id="A0A401GS34">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS34"/>
    <dbReference type="GeneID" id="38781886"/>
    <dbReference type="InParanoid" id="A0A401GS34"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="5">
        <location>
            <begin position="166"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="6">
        <location>
            <begin position="330"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="7">
        <location>
            <begin position="501"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="615" mass="68238" checksum="3F60B1D4D85C3529" modified="2019-05-08" version="1">MDTPRSRRPSRVGTPITGPSPSRLAPPVIRPAPSVSPYRVYSRGSSALQTPVSASPPDDAVSHGVHEAVSSSSSSCLTVDMSEGILVQESEVEAETADAERVDATGHVESRAGDEESKKNLRETLRQTLNKKESRSDLSSRPPRRKGKAVDISEVPLTVDIYPPRQYFVLTDAGKPVFISRREDDDSESFTSTIGIMQALVSVFLDDGDKIRCINAGNTRITFLLRPPLYYVCVSSWGEPESVTRFHLEYLHLQILSVISAEQLRRMFERRTNFDLRRLLSGAEPLLFSLLARMEWDLAMSTSSLHSLRLDPALRKSIADVLVPTSKIKDMLYVILVAQERVITLVRPKKHSIHPADLHILINTIHSPSILNSSASASWLPVCLPKFNPAAFVNAYVTFLRRENEVSTPKAPEGSENGTPTEGGHRAGSASSSITDIPSPEEPVPHIGLVCVSGGADFEVVRHWCDTVTQRMEREKLLSTLTEAINSGETDYSVADLGIPGLRHFVYKSRSHVQVTMSQFDDPYDDANEKRRLITLYQTLYDAIHAKSGQESTLKLQYLRTERESVMGWITQPFELYLALSPRLPKSAAVGAANAVARWVAKEEKRLFLRDAPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS76</accession>
    <name>A0A401GS76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable quinone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0702640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615991.1">
        <property type="nucleotide sequence ID" value="XM_027760190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS76"/>
    <dbReference type="STRING" id="139825.A0A401GS76"/>
    <dbReference type="GeneID" id="38781995"/>
    <dbReference type="InParanoid" id="A0A401GS76"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="335" mass="36351" checksum="1267FF2C98385AB6" modified="2019-05-08" version="1">MRAVLIREEKGPLENLYLGETTRPSPKQGEVLVKIKAFGVNRMDILQREGKYALPADASKILGVEFSGHVVEVGRDVAEWKEGDEVFGLTSGGAYAEYIVVLPANLLRKSPSLTWEEAASIPENFLTAFQALVVIAEVRRGDDVLIHAGASGVGVAAIQLARLYGANTVTATASTKEKLDWLISMPNGATHSINYKSRDFAAAVKKITNGKGVDVIIDAVGQSHWHKNIDALAVDGRMTLLGLLSGGEVPSFNLAPILFKRLKIEGSTLRSRSPDYQAKLISRFKDEVLGFLTGSAGEGALRTYIHKVYPWTEIQAAHREMEANKNSGKIIAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSU4</accession>
    <name>A0A401GSU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0704950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616221.1">
        <property type="nucleotide sequence ID" value="XM_027760420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSU4"/>
    <dbReference type="STRING" id="139825.A0A401GSU4"/>
    <dbReference type="GeneID" id="38782225"/>
    <dbReference type="InParanoid" id="A0A401GSU4"/>
    <dbReference type="OrthoDB" id="428177at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="56" mass="6321" checksum="2814E621522AEC25" modified="2019-05-08" version="1">MHSYNALGSNDAYGSAYGTGDFYTDSTAQWAFDDRLKYILNHNHSTLGTLWKELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT85</accession>
    <name>A0A401GT85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0706380</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616364.1">
        <property type="nucleotide sequence ID" value="XM_027760563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT85"/>
    <dbReference type="FunCoup" id="A0A401GT85">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GT85"/>
    <dbReference type="GeneID" id="38782368"/>
    <dbReference type="InParanoid" id="A0A401GT85"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="98"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE85451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="564" mass="60316" checksum="CCADC8A40F2010A4" modified="2019-05-08" version="1">MLAASASLLNIDVVILDVGDHTPAKQVVAPRTPRLSHIDGSFADAQKIRELASKVDVLTVEIEHVDVAVLEQVESTVPLGVHPSPSTIGIVQDKFVQKKHLFSHDCPVSEFMQVESTVEAIQHAASVLGLPLMLKSRTLAYDGRGNFVIRDLSQIEAAISALESRPLYAEKWVPFVKEIAVVVVRSTTGDVRSYPVVETIHKENICHLVFAPLRSRDPTVCSRATAVAEAAVKTLRGAGVFGVEMFLMEDGSVYLNEIAPRPHNSGHYTIEACETSQYENHLRAILSLPLGSTALKVPSAAMLNIIGTSSNMSEISTLAHHALTVPGARVHLYGKSECRKGRKMGHVTLVANSDGELRARVRTLLEWLPSGGDVDEVNSYAPLPPLPGSGHSHPQPLVGIIMGSDSDLPVMLPAARVLDRFNVAYELTIVSAHRTPDRMVEYAHSAASRGLRVIIAGAGGAAHLPGMVAAMTPLPVIGVPVKGSSLDGVDSLHSIVQMPRGIPVATVAINNGMNAGLLAVRILASGMPDLADAMSVYMKNMESEVLTKVGRLEEVGWENYAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTI1</accession>
    <name>A0A401GTI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0800490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616445.1">
        <property type="nucleotide sequence ID" value="XM_027760644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTI1"/>
    <dbReference type="STRING" id="139825.A0A401GTI1"/>
    <dbReference type="GeneID" id="38782449"/>
    <dbReference type="InParanoid" id="A0A401GTI1"/>
    <dbReference type="OrthoDB" id="2800295at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="255" mass="29350" checksum="63963B9C31F0AA1E" modified="2019-05-08" version="1">MDPQHLQQLPGAAACLLEAQMVCFQEVVDEQIEEQESMEQAMDVDNRLDADSHYLREPDPVHKKQKLSASKENLVENLKKASAHVIVENMQNEYQRNWTQFTEFCAELGYVEEPEDVDNLYPNIPSDFPTWIAIWIMNKADELDVRTGKPKDPSIAHVTYGTAQKMRAAISHKFGCHYGLGTQQWIENPLKLGEYIGNPSLFVTVSQYMVSLRRRKIRGGEIVTSARAIDQEMMRMLWAFNIEFPQEQYAPVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTN6</accession>
    <name>A0A401GTN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0800660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616462.1">
        <property type="nucleotide sequence ID" value="XM_027760661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTN6"/>
    <dbReference type="STRING" id="139825.A0A401GTN6"/>
    <dbReference type="GeneID" id="38782466"/>
    <dbReference type="InParanoid" id="A0A401GTN6"/>
    <dbReference type="OrthoDB" id="2758522at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019052907" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16866" checksum="87172E986F84DAD2" modified="2019-05-08" version="1">MAASFENRSIQLAAVLLMLSALPTAHAYCYIDSDGYERCTMATGVRAAIGIVIAVVVVLLLFVVMWMRRRQVQRRNLAYIAAPAPVPPPAYPQQGSPYIDGGAYMANGNAGYYQPEYPQYPPPTLGGYDPQNGFAPPYQPPKYSPPAGVSPAKVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU14</accession>
    <name>A0A401GU14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616638.1">
        <property type="nucleotide sequence ID" value="XM_027760837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU14"/>
    <dbReference type="GeneID" id="38782642"/>
    <dbReference type="InParanoid" id="A0A401GU14"/>
    <dbReference type="OrthoDB" id="2728951at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="391" mass="43250" checksum="1774607C5D3DE26A" modified="2019-05-08" version="1">MQKLWDHCRDTPLPEGKEEEADDAEGDMVFARDMFGSGRMEDDVIQYWWSPKDQLPLEERSAFTDARALGLGSRELRTASKPELVDGSWTGGVAWERDTQAKPISGSARCYTLRQSYESQKNLSAPVPGAKIFEECVNEHQKMCKTIIQASSHLAMSAFKHAPPYLKQALKCQADVTNLPPLGHSGNYAFPMQQINISATKPSNTLAIAHFKGDLGKFAGKHIDHQDAPEGVTCMHSHSDLDEDDHPGLFYLPEIGAYMVMRGMISVCFSGLRFHGGIPPTSPSDREPSPYSYRIVVVNYPPSALINADGLVGFTSMPNGSLLSLRPEMRDLIYNNPSAFTFSNHGNWGTDGLALTEHCAMFNWYARAMAQFSAYLLRGLPSSLAADFYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU30</accession>
    <name>A0A401GU30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein vip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0704200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616147.1">
        <property type="nucleotide sequence ID" value="XM_027760346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU30"/>
    <dbReference type="FunCoup" id="A0A401GU30">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GU30"/>
    <dbReference type="GeneID" id="38782151"/>
    <dbReference type="InParanoid" id="A0A401GU30"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="264" mass="28243" checksum="EB149197219F8D95" modified="2019-05-08" version="1">MSTHAVQVSNISPATTKEHLEDFFSFCGRIASIEYTESSNIATIHFEKPSAAKTALMLNGGTLDNSHLTVTSEVEHVDEKVTTHDGKYEQSDKPRAGIAAEYLARGYTLSDQILQRAIEIDRQQGISSRFLSYIQSLDAKLGARALGPEQTISGKVQETLAHATQQARAVDEQKGITKQAGDYYARALAMPLGQKVKEFYTTTSKQIYDIHEEARRIADTHKAAGVGAPTAASTGPTAPAPSSGSAGTSGAEVDTKTKDPSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUH8</accession>
    <name>A0A401GUH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0803620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616753.1">
        <property type="nucleotide sequence ID" value="XM_027760952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUH8"/>
    <dbReference type="GeneID" id="38782757"/>
    <dbReference type="InParanoid" id="A0A401GUH8"/>
    <dbReference type="OrthoDB" id="2800666at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46085" checksum="D926ECA4ECAABDEF" modified="2019-05-08" version="1">MPNLLWGTVPTVPPVILYILPHAHRIRSLRWLGLSRSEMQILLSNLIFAAPSLETLELSCSHHGKRDDLLFAPAENQFPRIRSISLSGIFIPLSLSMFRGLVSLQLGHLNSSHTPSMDMLLDVLEACPDLHVLSITHPPRKSAQNWHSNSIVSLPRLSQLGILNMSPDMPRLLDYLRISAQTCVDIRGQSTLAMSDEEACAPFLFSGRTRLPNLTDVTDVAISLSTLLSFDLELTATAASAQKLRVRLAYTQFSRSAPSKGASTVYRAFAQLFGSSPVRSLCTSGMGGTVDTWRDTLRSFPLLQRLHVQFIGAEEAVSLLRCLAGEAEEELVCPELVHLGLPNHLDPQLLAAVVVCLDRRAARGCRLGTFSWRILNGSRQRFRLKMETIEMIKRKVEVFECDASEARRSVSAAILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV13</accession>
    <name>A0A401GV13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Six-hairpin glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0800910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616487.1">
        <property type="nucleotide sequence ID" value="XM_027760686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV13"/>
    <dbReference type="STRING" id="139825.A0A401GV13"/>
    <dbReference type="GeneID" id="38782491"/>
    <dbReference type="InParanoid" id="A0A401GV13"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814:SF1">
        <property type="entry name" value="CELLULASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41814">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019400208" description="Six-hairpin glycosidase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="49259" checksum="F0FC41664D63E4A1" modified="2019-05-08" version="1">MKRVLAHAVLFLAAARAAAQNLTGTQLDAVIAVLQANAQQTWELGTECEALTEYYAPSYAVFNASSLSPSAPAPASLTPVLSIAHNVIANRSASNSNKTGPQPLVYVSGGAAGDPASIGVAVLLANLTGQQAEDGLDYAGAARDQLAYLLQDVPRTGDGAISHRVEEVQLWSDSVYMVPPFLAYYGATAGNASLLTEAYTQVKLYRQYLFNGNVSLWRHIVLGNQTDAGHWSTGNAWAAAGMVRVLGTIQHSAYAGSMRSQTNDLVAWVGEIHKGMYTRQQASGLFTNYADEGSTFEDASSAALLASTVYRLALLADVGTYISHAERARVALSAAGDNGISSSSSSSSSANTSASASSDSSPSATIANTNSTATSSLPASTSTPSASPSYSAMAGLAHFTNQGYLTPVVDPYSWGAQASPGAVSPEGQAFVVEMQSAWRDWVLAGAPSASAALPRAVTAWGWVVGASVGVVLMWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV31</accession>
    <name>A0A401GV31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0806150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617004.1">
        <property type="nucleotide sequence ID" value="XM_027761203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV31"/>
    <dbReference type="STRING" id="139825.A0A401GV31"/>
    <dbReference type="GeneID" id="38783008"/>
    <dbReference type="InParanoid" id="A0A401GV31"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="255" mass="27840" checksum="DCFB0CBF47F627F8" modified="2019-05-08" version="1">MPRSKEANTGSVSALIAQETVPEGIDSFELPRSLVTRIARSALPDHVKIQKEVILSIVKSATVFINYLAATAHDVASSKQHKSISASDVLKGLELIEIGDMVELLQQELLVYREIQKADKNKRGGGSVASVKGKARESEQTSISAASAKSKGRGKEREKGPTITISRPQARASAPGPATEFEQGEETDGDLRPEHDTELDQVGDPDDEEMLDYSEVQEDAYEEGREDAGEIEDVMVVEEEEQTRDARGLEEADYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWE3</accession>
    <name>A0A401GWE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0904240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617458.1">
        <property type="nucleotide sequence ID" value="XM_027761657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWE3"/>
    <dbReference type="FunCoup" id="A0A401GWE3">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWE3"/>
    <dbReference type="GeneID" id="38783462"/>
    <dbReference type="InParanoid" id="A0A401GWE3"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="314" mass="33519" checksum="3DA9987AFE39F9EB" modified="2019-05-08" version="1">MDSSELYVVKQHFILGAYKMLVDLTLPDPSSPDYAPTLVYQARAHIALNKPRAAADLVPADTEDVSLKAVAALARYVGASVSADKDSSLEELRDLCVEIEGEDLDATDKEKGMVRILAGTAFAIAGEVEEALETLGVGTTTDNLEAVALIVQIYLSINRPDLARKEFERAKRWAEDDLLIQLIEASIGLVTGKDGYTDANAFYTEQLANPSLSSPRLLTARGVTRLLKGEISGAKSDFEEAVSQSGGVADAETLAAMTAAAGLGASKYAEADQLWSQLTSEYPKFPLVVDLTGKAELFDDLCTKFEVPPVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWF0</accession>
    <name>A0A401GWF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0806180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617007.1">
        <property type="nucleotide sequence ID" value="XM_027761206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWF0"/>
    <dbReference type="GeneID" id="38783011"/>
    <dbReference type="InParanoid" id="A0A401GWF0"/>
    <dbReference type="OrthoDB" id="2526341at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="664" mass="75933" checksum="26DA2F20D3F49DCD" modified="2019-05-08" version="1">MAPTLRKRKQGPDKQIPAQVEAARPPRRKQRLTQAIPSQGLEGPSSAALMDVPFDIFFEIFRHLSPKDLLNLILTNKLLRATLTHRSMDVVWRQARKGSANLPVCPPYLREHHYTDLIFGHHCHQCGANGPEVKATFEFSARYCHDCQRDMIVEKPYNTSQPYFDLCVPLRNQTSSMGIYHRPEVNRMKVLWQQARTGEEQAALITLRNTFLDQHADHVDACQRYIQVQENIYRARQQRLKDDRIHSICRRLDTLGFDTEILCSKTQLNALPMVGVAERLTDADWEKMKPKLVVFMTERKECRLKWQRIHAMKARLASLTASLKKARMSLEEYDALPHAADLISFTEIRTIVELPDSVHIPGEAFDQILPDLSERWQKDVLARLKTKFPDIASTSCRRKAVPFQDLAKTAFQCSSCRRVLFWPMVASHYHSPKTIRPNNYAFGPWRTDYPPLKIPVFDAAVQGEFRNRKQWTTAPIRLYREQAVQVINACEMNPDTVSIAEMDEQDARISCRLCSVPGESKLVMSWRAAMSHCLTVHRSQPVSEIQWDQISAAQEKRVRSLEKTRRYKSLTEYNAQPACCALCNYGTSSAYSAPTSIADVQNHLRVSHAGNQDPKAIYITKDTPPFVPLAVRLYSNAVTSTVKADYQVLALFKDKLACSVAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWN5</accession>
    <name>A0A401GWN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0904720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617506.1">
        <property type="nucleotide sequence ID" value="XM_027761705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWN5"/>
    <dbReference type="GeneID" id="38783510"/>
    <dbReference type="InParanoid" id="A0A401GWN5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28225" checksum="990CB9FDD0D65DFC" modified="2019-05-08" version="1">MMLDRYKQVGPMSAKNHYHRTQLEQKAVPLGTAYSLAHMLLTHGCFCDYMRRQRSTPPPASSSTKAALPVTTSASPLELHRTSLSVGAIIGAVLGGIMVVLLMLLLVRSFWYRRKSGQGSGHASSDPDPLLDATDDTDVTQMAQEIPPVLDISMATLLSIAPATPTMPALRSSTASPTLHSSCPPSSNELTLLGLSAVGDGIVSTSTGGKSSRFSDPYPARPPVIAAGIATAVPLYEGHTSDPGMRSTLPSESSVTLVSDPPPPYMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWR0</accession>
    <name>A0A401GWR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Bifunctional purine biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0904880</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617522.1">
        <property type="nucleotide sequence ID" value="XM_027761721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWR0"/>
    <dbReference type="FunCoup" id="A0A401GWR0">
        <property type="interactions" value="671"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWR0"/>
    <dbReference type="GeneID" id="38783526"/>
    <dbReference type="InParanoid" id="A0A401GWR0"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE86609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="600" mass="64622" checksum="DA6EA23146619FF4" modified="2019-05-08" version="1">MAVPIALLSVYDKANLVDFASGLHAAGVRLLGSGGTAKKIREAGIPIEDVSDITKAPEMLGGRVKTLHPTVHGGILARSIPSDEQDLKAQSISPISIVVCNLYPFTSTIARPGCTLTDAVEEIDIGGVTLLRAAAKNHERVSVLSDPSDYTEFLDAWNKGDGDVGQSIRSKLALKAFEMTAEYDDAISGYFRVQYASADLPPKKLAGPVQRMTLRYGANPHQKPAQAYVTEGELPFKALCGSPGYINLLDALNAYALVKELQEALNLPAAASFKHVSPAGAAVGVALDETEKKVYGVDDLKEPLTPLACAYARARGADRMSSFGDFIALSAPCDLATARVISREVSDGIIAPGYSTEALDVLSKKKGGKYCVLQIDPSYQPAEVETRQVYGVHMQQKRNDAKIDASLFQNIVTKNKALPAQARTDLIVATLALKYTQSNSVAYAYRGAIVGIGAGQQSRIHCTRLAGTKADLWWLRHHSRVLALPFKKGVKRAEKANAIDLFVGGEVLEGAEKAQWESLFEEVPQPLSAEERASYGKQLDGVACSSDAFFPFPDNVHRARRSGVKYLAAPSGSVMDVECIKAADEHDMVFAHTSIRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXX1</accession>
    <name>A0A401GXX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1002550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617922.1">
        <property type="nucleotide sequence ID" value="XM_027762121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXX1"/>
    <dbReference type="GeneID" id="38783926"/>
    <dbReference type="InParanoid" id="A0A401GXX1"/>
    <dbReference type="OrthoDB" id="2423954at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="100" mass="10771" checksum="3421F1C8641EC426" modified="2019-05-08" version="1">MDSIEANGDTEDDHDIVASGPLILSPSSSFEATPQPRKTSIPLRALFLYPTVGASNGNDSEPGLDFYWHGEMKNYAQELAQYDLLHTIQGSEPIGTGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY70</accession>
    <name>A0A401GY70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SCP_1004150</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618081.1">
        <property type="nucleotide sequence ID" value="XM_027762280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY70"/>
    <dbReference type="STRING" id="139825.A0A401GY70"/>
    <dbReference type="GeneID" id="38784085"/>
    <dbReference type="InParanoid" id="A0A401GY70"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:transposition"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
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        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="RVT_2"/>
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        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="23" id="KW-0862">Zinc</keyword>
    <keyword evidence="23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="25">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="26">
        <location>
            <begin position="521"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="787"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="839"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
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            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE87168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="29">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1062" mass="120381" checksum="66A282966B699493" modified="2019-05-08" version="1">MSNSNAYRIPLLKEDNWLPWKRRVEAILNDKGLQEYVTGKTLKPQPSNDPANRAAREAEISAWGEKDLKAQNVIVLSLGDSQMVHIAGAKTAWAMWEQLRTVKEQRGQHGILALCWRFYRMQAKEEDNISSHITQLRQIQEQLHLMRKVVSDEDFRLILATSLLESWDSFLSSYFGAEGADNVHPQLTSQELIAIILDENRRRHERGERGQSSDQAMVAKGKKRPFGEYKKCSICGKPRHLGNECRHRDKVKCMNCGKFGHKATDCWAKGGGKAGQGPPMKQQKTECAYEAHEVESKEDEAKIAYDNDSDTVSLGSDGKIASFYEWFADSGTTSHITNRREVFTTYQALEDHAITGIGPQPMQALGRSTVDVKSEVGDRKVKFRLHGVLYALTAPNSLLSITHLDDAGGRVLMGNSRAILIDKNKHTLAIGKKNGRLYSLKLRPIVPQPARTYTAKEYGPHTWKEWHKIYGHIGKPALMRLYREGLVDGLEISPSPDEINCEACIQAKATWKPFPKETDECSKVPEELTHTDVWGPAQTAALQGWKYFITFTDDYSRRSTVLFMRHKDEVTEKVKNYITYIERKFGNKPLRLRLDNGREYMNTELINWCQMKGIEMGPTALYSPSQNGVSERLNRTLLGLACAMIYVRDLPCYLWAEAIAHAVYIKNRSPTQALNGATPEEKWNGMKPNISYLQEFGSLIWVLTEDATLSKLAPCANKYIFVGYMDGPKAIKYYDAHTRQIKISHNFQFSSNSPDHLPGNVPHVPQEQIGSDVPILTAQREREQNIFPGTLPSNASDVPHAERRPKVPNLTTTTDVQREGELGTSAPQSPAKNPRKRRQDNDPDQREESGMDAPSQPRRTRRKTVWHDYRLMHNPEADEDLDNDPDKSNAELVYIAMSTHENADADEPKTLSDAKRSLEWPKWEQAVQTELNQLQGMETWELVEPPEDRKPVGNKWVLVKKTNKEGEIIKYKARLVAKGYSQIPGIDYTETFAPVVRLETIRAILGLAAILDWEIGQMDVKGAYLNGTLKEEVYMWQPEGYSNGTYRVCKLKKTLAENGISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYH4</accession>
    <name>A0A401GYH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1002190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617887.1">
        <property type="nucleotide sequence ID" value="XM_027762086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYH4"/>
    <dbReference type="FunCoup" id="A0A401GYH4">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYH4"/>
    <dbReference type="GeneID" id="38783891"/>
    <dbReference type="InParanoid" id="A0A401GYH4"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="728" mass="79930" checksum="BA495B70CC060C38" modified="2019-05-08" version="1">MSGFRGPPRKGENFELSADLNSEHREKRKDAIKKVIANMTVQKDVSGLFPDVLKNMQTDDLEQKKLVYLYLMNYAKTQPELVILAVNTFVKDTDDPNPLVRALAIRTMGCLRAEKIIDYLCDPLRKCLHDDNPYVRKTAALCVAKLYDLKPELVIENGFLETLQDMIGDSNPMVVANTVAALTDIHIAAVASGSTKETFVITSTILNKLLVALNECSEWGRVAILNALARFETSDDRESEHICERVVPQFQHANASVVLAAMKVIMIHMRGVHSESLTKQLVRKMAPPLVTLLSNPPEVQWVALRNINLLLQKRPEILSNEMRVFFCKYNDPLYVKVEKLDIMVRLAGESNVDALLSELKEYASEVDVDFVRRSIKAIGQTAIKIDEAAERCVNVLLDLINTRVSYVVQEAVVVMKDIFRKYPSTYEGVIPTLCANLEELDEPEAKASLIWIIGEYANKIDNADELLGIFVDTFTEESYPVQLQTLTAVVKLFLQKPDSSQGLVQRILNTATKDCDSPDVRDRAYIYWRLLSTDPGAAKAVVLSHRPPISLPRTTVSPQLLEELLGEISSLASVYHKPAETFVGRGRIGIDSVQRRGTDSELADDRSATQKALQTVAAGQQAENLLDFSDVDGVDGQQPSGLAATTVLTETPAAANLLAGTSSNPLDDLVSIFGSVAGGPAAQLPSANPLGGFAFGAPASPMPPAIPSVVQTPQPQPQEAQNDLLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYK1</accession>
    <name>A0A401GYK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1004900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618156.1">
        <property type="nucleotide sequence ID" value="XM_027762355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYK1"/>
    <dbReference type="GeneID" id="38784160"/>
    <dbReference type="InParanoid" id="A0A401GYK1"/>
    <dbReference type="OrthoDB" id="5983317at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="238" mass="26174" checksum="55D151B644BE7C19" modified="2019-05-08" version="1">MSLSVEARHLYIESLDIPEGASTRVSKGSSAAVNGGSVDTFVGGLSGLNKEDVLNSTLLAQLSANQAAGGDRIRWYNKYREVLENIGWVVQDFTFKELDNATAHGSVDQAIIAILKSYLSHTALADFKATIDAMKKPANNNANKLFEMNAWKGQESDFQLGVASASHDDVQFRIGSFTYQAQGSQNDVLFFKFGHDHVKFMYSTQNMVLNLKVYEKVRAAVNQKLGSHVKSYIDGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYP4</accession>
    <name>A0A401GYP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1005260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618192.1">
        <property type="nucleotide sequence ID" value="XM_027762391.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYP4"/>
    <dbReference type="GeneID" id="38784196"/>
    <dbReference type="InParanoid" id="A0A401GYP4"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23833">
        <property type="entry name" value="UBCc_ApmR795-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="1175"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="1418"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1577" mass="175083" checksum="71A09049297F40C6" modified="2019-05-08" version="1">MQTEKMRVFVEAPPITPGGVRRRLVVPILRTKTVADFAEVVARRIALNNDSASDLTLTLADGSMLFPEDEIQDVVQAEDVVHINFAHNQETGNSYPILSPNSNTQPTSSTNPPQMSRDAPEHRRNEDTSASFTSSSSEKRVRIALVTPKLARNVGNADIAREMAFGGSAVSVKLTMDIVRREAARTLGWLENHDVTDVDRPTNSACDHIHGSCACTVANQIVAQGRFEQFHCPREIDGTVCDDTTCPYSHAAMASGDLTGHIADIQCKICTELFGFACEKYCPLVQNAGCKHIFHAHCYFAKTFRSQGCPAGCTTSSIGVEAIPFDMQVPHLVVVHSGSIVEKVPIPMRYLAEHGAQIELTDEDVMNILASKYSDLGPGLVVRMYGRKFTGMVSFRHSTVVSICCASRHDVDGIQRFALNGPPLPVLSSRSAVDLHTAFSPILNEAPYLTIEDLMLDYDIPDGDEIVLYVNKRPKINTKPNTEQRVGKAAVYTARDDWQPVVRQTDRGMAAFLSSLLVFANYLSVAGNSNEEKNMQNRVLNHLLALTRFPPAVRALYILTLNESLLPEEMHALSETVYHLALDVSHPFVTKGDLSRAFEGARVLFGVLIERTKGVFTFPESDVRASQSKLFSKVLLSCGLSGEPLDDAVLYGDILVNRAAVSIRRLGGVLFDPSVGTPEVTPVPIHVQRLIQSSGRKTSQLIVFNDSVEPVTILTHSLRPSTLAAGIDKANVELQIHAPLSLREVVTPALTLDEVGFNAVYIARAAPCSDGGEDGFLLRPCHGGEVGLDVNLVATKLQPIIERRKAIGEWDIDAFGASRTDRLDTREIEEAIVVALDVSRSMEQKFDGDSDDEDSQVDFDEIALNKAMEEFSKRHHQASDALMQAKMFLTSLDCLASVTRYICHGETTLHSGSGRQPRVRAEEALKELVVIYSRMHSAQFRVMEFAPIRSFNLSRWEDFIAVATDNLTKPQLLTYLVQQAAAIKENENLLASNGVPKRFIDPLSGEVMVDPVRASDGVIYERSRINAWLEHRSTSPMDPTVLINSTLVAISSLHNPIRTFLGGRPRASLQQHQQPLLIRVKTMWGRVLEYVLNTEANTILSVLFENWLFTGRAPSVSCLWHGLTDCGDGSMRGRRLEPASSLRSLPSQMQVFRSTEGLGFSLDVVELNHRVWRHVPDNADRIRKDSRSMSRLDIVKQAFEAFVNKSEAFDHPIAIGLVTFGRQVHEVQDLTLLKERFRDSLRTIMADGDTPLFDSLSVAHSMLQTFKAEHPTTALRIICLTDGCDVGSSTLPHQIAKKLQRSKITVDSLVVQTGDLTNVLHPISVVTGGYSFKIDTLENALNIVELETVLRMKDRLERPRQPIVRNPWRLLEYNDLSKYPLDIVTADECPDRKPHARLHEPLLAASRAAARALPPSTDRQRRLMQELREVMNSPHPAIDVYSGSDLAFWKIVIEAPKGSPYEGGTFLAYVDFGSNYPQSAPEVRFITPILHPNINRHGKVCHAALDRSWVVDMTMKVILQVLYGILLTPDTDNPLDLHATMEYNDDTGIHAQRVHEMVQRHALKTRAEWKEVLEAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZQ7</accession>
    <name>A0A401GZQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1103150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618551.1">
        <property type="nucleotide sequence ID" value="XM_027762750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZQ7"/>
    <dbReference type="STRING" id="139825.A0A401GZQ7"/>
    <dbReference type="GeneID" id="38784555"/>
    <dbReference type="InParanoid" id="A0A401GZQ7"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="110"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="289" mass="33088" checksum="38A306EED5C60C55" modified="2019-05-08" version="1">MAPSKARRASHRAAVHSPYFPAPPVRRRREKSPEILYTSAYFSPERVQKTSLDSGTAPEGQPTEYQSLLELPGFKYYSQDFLSAFEELYFAKPILIQDYVAHDPWKVLCAVMLLNKTTGAKAVPVFFNLMKIWPTPRDFAVAPQDAVEEIVRTLGLSNIRSERLITLSRMYINDPPRPDLLRKSRCKTTSYSSVGANGGQHVVAEQTDYKRTPVSHFPGCGPYALDSWRIFCAGDEEWKSVLPKDKELKRFLRWKWAYEEFRQWDPELGPGNVITLDYVRDMTALLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0L1</accession>
    <name>A0A401H0L1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1201800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618867.1">
        <property type="nucleotide sequence ID" value="XM_027763066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0L1"/>
    <dbReference type="STRING" id="139825.A0A401H0L1"/>
    <dbReference type="GeneID" id="38784871"/>
    <dbReference type="InParanoid" id="A0A401H0L1"/>
    <dbReference type="OrthoDB" id="2799175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39424" checksum="203E19DCF25434BF" modified="2019-05-08" version="1">MKLLLPHIGRWRKLRIVVDRAVSLPCPGLDLCGNAATLTRLQPESKLDQPARRNTIDPLAENFQTPALNELITSGHIFRDAYLLSPKSLASITTLTISHYMVDSKPFFIHHLMHCLYRLQNLTNLELMYLDLDCSSEGRGLDDDQQLDIERMHFQGMHVSSLSSFYRAANYPRFIYLTFVWCELTEPIHMGGCTKLNLCNLSPDSGIRILLEDWDGDNTLFVIQCSNFNGHVLQQLSEEVSIGEWLCPRMTSLVVAYSTSFTSENLQRMVQAHREEHAKSGFADWDDLDDTIPSIESLLAFRCSDLASKDKAWFDNNVQYVSWDEWWGGMNIGAFMAGNADDFESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0M7</accession>
    <name>A0A401H0M7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1201650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618852.1">
        <property type="nucleotide sequence ID" value="XM_027763051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0M7"/>
    <dbReference type="FunCoup" id="A0A401H0M7">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0M7"/>
    <dbReference type="GeneID" id="38784856"/>
    <dbReference type="InParanoid" id="A0A401H0M7"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="40275" checksum="FE287EDA76FA4C49" modified="2019-05-08" version="1">MKYIEVPELERLAQALTHEGPECSVHTRIEAYSCKNIKRDKKLFRTLENAYNDELSNSPPVPSFIALDREPDMTPFGPMQEQHSRRTLYLLIATLNVAFPDHEFSDVRPWHFSREESGASVLNSLSTTLASPHRAGMQAPRTYSAYPPTSADFFPSSVPTSSSPSDYFKPSPHAPSKAVSGTHPTLYRILNDVIGLSDCEVYSYSPDIEFDPHANDFSDDEDDLASVGDAESSTDDEETTFQFDDYDVDEVRRQPSWRSTVTTSSEDSDDLLARSMSPMHIRMKRRGALLWSSHWFFLNRKLKRILFISVWARAKSIQSWVDDEEAYGSPGKVTGERFLGWEGAIGAGARAMGLRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H119</accession>
    <name>A0A401H119_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1203090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618993.1">
        <property type="nucleotide sequence ID" value="XM_027763192.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H119"/>
    <dbReference type="GeneID" id="38784997"/>
    <dbReference type="InParanoid" id="A0A401H119"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="7"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="908"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="908"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1046"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1279"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1290"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="939"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2451" mass="266350" checksum="0D211CAD8E886F75" modified="2019-05-08" version="1">MGAATHCTEIAIVGIAAELPGGYKSAKNLDYKAFSEFLLQKGEAYETIPLERFNIEGLRGQGVGKVLTDTGAFLKDVHLFDYLEFGMTSRDARLMPLSTRKLIELAFLSLLDSGIDYRGHNVGCYMAGVAHDMFAISGHDDYEARGTFVYGPAMVANRVSYHLDLRGPSIPIDTACSSSLYATHLAVQALRNGECEAAVVGGCQINHRHVIDLRPTISCILIRHARFAEWLIYSEGGVLAPDGKCKPFDASANGFGRGEGAVSIVLKPLDAALRDHDNIYGTILGTGVNSSGSQAPANAPVAAAQQDAMLRAFVQAQRLPQEVDFVELHATGTAQGDPAEANWVGAQFQKGEELIIGSVKGNIGHLEITAFLASLCKVCSMFQTRLIPPTVNLDTPNPSIRWDEYRLRAPTEVELLPCGGASGRSLVALASSGIGGANAHCVVQGPPLQRSHVSSFWSNDDVPALFIAGGLSPRSTTALYEELQERDILENVQYLSRIYGRRSRSMNWRSFAVAHDGRLSSFSKAFMVPKSTPPLVFVFSGQGPQHLNMGRELFKTCSVFSQSVAEMDEIYRSVLGHSLLETTGLFADHVGNQPLGDIWPIAVTLPALTILQIALVDALASLGIRPNVVIGHSAGETAVLYASGSGSKAMAVELAIARGRAMSLLEDAHGTMAALSCSPSEAAQIIQAVAAELGSAAVLEIGCYNTPSAVTLSGAEDAIDLAVKKAEALGFLARRLRTRIPVHSALMALCQEQYEEYVHDVFLRYNTSKPTVETYSTKTGDLFNTPFDAQYFWDGTRGPVMFTDAMQASLSQNPNSTFIEISPHPVLSSYISSMAGKDSTVLCPLRRPKRTEHSVETLGLVDSLGRLIVAGHNCVNFDVLCHATGDVDETVPPYPFARKDIPYRAQTAEVTRLRQSRNGPLNYPQLQVNAKTHPGLAEHVIKGEPIMPAAGYLEMALEFGAKKLLNVEFISFLALSSEHPTPVHVKLEGSHWTVSSASSADFTKSWPPQYNRLHAKGYLSMNASAGEHRDPVPLDYIRERLQPVEMNGNLASHSYAPASDWAVRILACNMGTDENGRDEVLVQVRGADHDIPDLSEYHIHPAILDCALHVVVHPLITGSRDKGRYYLPSKVGTLIIHDALQKKSFPRMIYAHAVLHKWLPDSLIWNVSIVDEEGTHLCTLEKLEVALHGQSRKAVQKRYDVVYQQAGISVAGRHKSNDPRLSADVVSPLARVAGIYGLASSVAMVSRFFFPFRSVRQLLFPSASEYVARIPTSGSWSSHTEDDSHKQESVSDTASVSSSAGDEHASSASTLGGESSPVVIDFVRGKEIRIQKLVASLDPLAEHSLWFLATMGLDGDASLGFTRSLRKEYRVWTIRVVVFDSAWTDLIERRNVMHDLMDVPDCELELMVDAHGSVLVPRIAPTSPPPTVAVFRPHLPWRMQTSGLEQISLPPVPDEHVLVRIVSVVQGAGPLWSFVGQTDDRSSAVVGLAGGSPSNVIVAHRGSLVERAIPRGNLGPCVLASVIAVLALGISSFTHRERLQQSSILVTDADTTLGSQVAQIYTALRLHAMTLPAHCIADMMQFSEHPPKIVVSGTEDVSEIRALQDLVGSHGKLFLWNHRVEGIARILATDPWSIGDALRCAFKEGAEHREPFQRIADLAHPYASMQVPLVSSLFDHAKSYLLVGGVGSLGLRIALWMYQNGAREIILTSRSGRKSVTSRSESVARHILNYLESLPDLVLRVEAADAQSTPRMMRVVKDMQNPLAGCMLLAGALVDRSFASQTQETFETPFTPKVGAFKALEKTIPIASLDFLVAFSSVSGMFGNAGQTNYASANTALAGLTKKYRNAFTLVTPAIIDSYFALSAEAASKYGLLKHLGDWGMTGWDFCEYIGDGIRQLREGPVWQYIPDFDWRLVWDNMGPSTMYAQLVPDNVADSTEAQPEDAAVSLRNVVCKVLDVAPQDLSRDMPFTSYGLDSLSAASLSYALRPVLAVSQIQLLADLTLGQLEDRLKETTEDAIANGVDGVQDMQKETNKSREMLKFVERYTTNLLQLSSISPLFVSDTKNILITGTTGSLGAHMLAHLLQAAFPLKVYALLRKGPQGVSTAARQRKAFEMRGLDVTLLKDGRLVLLEGDLVAPSLGLSDVLFETVVESLTHIVHLGWPINFNGPLTMYEAAIQGLRALVDTSSKHRSASPAKLIFASSISMIRNLPYSHLVCEEPLLDPMIALDSGYPESKWVAERILGLALEKGLRTTVVRVGQLSGGANGAWKTAEWFPAMISASVTLGCLPMASGNISWLPVDVAARALIDMLDTPQSVLHLRHPTPMSISTVVPLFSECLGLPVVSYAEWFSRLKTGLARRENGTEAKGLAGLEPAMRLMNVFELSMQACSSQDNTEEGSREDFGLTCSVDVTEGLAASATLREAASTQIGREDVERWLNWWRDVGFLPAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3D8</accession>
    <name>A0A401H3D8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1403310</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619836.1">
        <property type="nucleotide sequence ID" value="XM_027764035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3D8"/>
    <dbReference type="FunCoup" id="A0A401H3D8">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3D8"/>
    <dbReference type="GeneID" id="38785840"/>
    <dbReference type="InParanoid" id="A0A401H3D8"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="535"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="855"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1042"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE88923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1246" mass="141139" checksum="6575422F05EA62E6" modified="2019-05-08" version="1">MPLIRIEVCDFKSYRGHQIIGPFHNFTSVIGPNGAGKSNLMDAISFVLGVKSAQLRSSQLKDLVYRGRRLARDPDADGSDAGRDEDGDEEDEQGEGEGTAKKAWVLAVFEDSEKKEWQFQRTINTSGTSEYKLNGKVGTYSVYNAALVSHNILVKAKNFLVFQGDVEAVASQSPKELSRLIDQISGSLELAGEYERAKEDQERATENATFNFTKRRGIAGEIKQYKEQKTEAERFESLCDEKDDLILHRILFKLYHIQEELEEHAQEIRTKNEELVGLREEQRVHDKALQDARADQAKARTAVMQKEKRIKKAEKTLDAKRPDLVQVDTQIKHSERKRDNALKEREKAGVAGQKQRDELRVLRADLEKVQRAADAAQEAQRRAAQASMSLSAESLEEYRRLKNDASILAVEERQALDTLSRDEKTSSRALAQLKDKHEQQMQKAEKLGEDKRVQSEKRSELEAKVASLHGELTKARQELDNQQSERTRIAQLEAEINEKLVDVHNKLLQAGVDQKESEREAKLKETLASLQRIFPGVRGRVVDLCKPAQRKYETAVSVVLGRNIDAVVVDEEKTAIDCIEYMRNQRAGQATFIPLDTIQVKPINDKFRSFAKGARLAVDVIQYEAAVERAMHHACGNALVCDTMEIARYVCYEKGQEVKAVTLEGTIIHKSGLITGGRSSHGGGRQWEEKDVQGLQRVRDNLLSQLRDLNKNKPRGKADENLIAEITRLESAHTIAKDDLSACKLRLNGIKDEIKHVDRELKQIQPELRKAQSAYDTLKEKVDELTTVVNAAEDEVFSDFCRRIGVANIREYEERQLKVARAEGEARLQFQTQIARLTHQSNFSEEQLQVSEERLNIIDTLIEAEEANIVRLQENQTNIKEEIDEVEGAIGALREELQNLTEVLEEKTKQVEQVKRTTTKSAKVLDQALKEIANGNDEIEKLGLERSAIYRKCRLDEVKLPLVEGNLKNVPMEENLRDEVAMDVDEDEDGTQPVKRIPDYGIEVDFEALDDDERGDVSADAVAGFDRKIAKLNSEIERMAPNMKAMDRLDDVETKLLETEKEADKARKDSKTARDQFNDVKRRRCELFNKAYNHISERIDQVYKDLTKGKAAPMGGVAYLSLEDSEEPYVAGIKYHAMPPMKRFRDMEQLSGGEKTIAALALLFAIHSYQPSPFFVLDEVDAALDNTNVAKIANYIRSHASETFQFIVISLKGSLYERSNSLVGIYRDQDVNSSRTLTLDLTQYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3N6</accession>
    <name>A0A401H3N6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE88999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619912.1">
        <property type="nucleotide sequence ID" value="XM_027764111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3N6"/>
    <dbReference type="GeneID" id="38785916"/>
    <dbReference type="InParanoid" id="A0A401H3N6"/>
    <dbReference type="OrthoDB" id="3227225at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="32149" checksum="77C4146C7CA68D39" modified="2019-05-08" version="1">MEAWWYKLGDPWEKVYTVSESTLVQLEQLHVRVANLTSWLHERTDQNLDVVLEELQEATRQLHQRTHFAGVVDDPIKMWEQLAAVHLQKKPGARFNAYDDVFFIRKQPEESLQGLVNKVNAAMQRVKDLRPNDFDLTKLDEELTSMAMIHALPVEEYGAFTSALLQCDILSKDVVIQAFVTEEINHHHRTTSSPKADQALTTASSSQLTCEFCEGKGHTQSNCYAFQNASKKAKENRKERHSKCGNKANATAAAAATQNTTQVDPTTVTEHRHHFSYDTSSPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3N8</accession>
    <name>A0A401H3N8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1500490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619960.1">
        <property type="nucleotide sequence ID" value="XM_027764159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3N8"/>
    <dbReference type="STRING" id="139825.A0A401H3N8"/>
    <dbReference type="GeneID" id="38785964"/>
    <dbReference type="InParanoid" id="A0A401H3N8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="37957" checksum="AF66D4C160B31070" modified="2019-05-08" version="1">MDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3W7</accession>
    <name>A0A401H3W7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5 16">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_1500820</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons. Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription.</text>
    </comment>
    <comment type="function">
        <text evidence="16">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 16"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619992.1">
        <property type="nucleotide sequence ID" value="XM_027764191.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3W7"/>
    <dbReference type="GeneID" id="38785996"/>
    <dbReference type="InParanoid" id="A0A401H3W7"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="1718"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE89079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1769" mass="197431" checksum="604A74135905A27C" modified="2019-05-08" version="1">MAKGKSSATSATRKKHARKAAGHLDEPAVPKEKKPKGKDKKNVEPRKKVYIPPVKPAPAQPDPLDTLGLAQRLPPELLVVLRRLPKKDATTKRRALEEFQSAWVDRGRFEGSDSTIVHALVDAIPVWLHHVPPLFLHPSRRIRLLAAGVHSSLLRLPGSVRDQLLFFIREVASMDQAQYILGSWCMAAHDVDRQVSALARDCWNDAVSLSKASGKKLVLNESLLASLWEFIQNTLLDPMAIYLYVNPPQSVTPASAPHKKGGRPVPRSIPPRQDEDASIRSKSEEDEENVQDRMARLRVGAFGSAEWVLNGHFDMEDGIIPEELLAPFSNPVLWSALYHLQTPPFVQVQSAGYGQPNVRKAAWSLLQTLLRTCRGHLKTQLPVLSSAVLRSAWIEPDQNVRGSMWQPLLTFLKEFPNAWEIAATSEKEEEADESGSDDSEDETLSPAQKAPAVPALGPSKAYREFLQFLELGCAGMPLQGYPTVLVILSTIPSSILASTSSLSPLEDLFASFWAAIDGRALSSLDRTTTSAAFLSSLLESLIFFVRRLMSSAPEDAALLAMGSPDADPSACTEVAKKLAREQFAKAWRELSAGHLKVENATAASLLARTLLSLNRLDTELFRAAWDVLSSGVKEQFKYNNTVISPLISVLLKVFLKQFQQGSLLEGATRVLTGDVLQAAVRQCDQMLNSIDAPSAERISSLVNVLDTFGERLFDDPELAAGIDETIQRHAYQLISFAPSLLLVYLSHRKDDALCSALWHRALLEIASHPDTAVTTLPPLLDAAERGFLPQYLKHEVNELDDLAGRLLTVAVTGTMGNPELALIQKLLRVSDFFFSASCTQGLVESICHAFAHHFHTTLYDESVALDSFDTLLELVRVLVENQSLPLPAKVSVALMPDIFLFAFLLPQFLQVEAEQLLLTRSLWEAWLAQVTEGVQENARAVIRRRLRELLVDCSARPAPEDILQMLVQDCPGLAVDVVHDVFPSRDDVDVMLDALPSMPADPSLAAMDPLVPPSSQYEYEWSHTEAFDHAGYSEYSRIINGLLLHLIQDRQAARENMWALRHFLALSLYADDFVKVPFAQSPVFKPHLPKTVLQELQSRVQQVTTYLLSSSQEEGWHASAVNEVLSGSAISHTDEVGRLIGDLIEHAKHDDTVRESRILYMILQHVLNNSSKGEANLWMSLCRKLEKSAPQTSLAIALAVTRFAPEPPLLDRYRNELAAAVLGVRPSKANTDGLWLLRRLNVTAPDPESDVVFLSQPRAVNFMKACQQWITSDEDLDEEVQGEMTSTFFHLVPILQNMPGAHWDLIFDVLENNLENSSFTEPSTLVTLSRSLRLFIAIQDLVSTNKALRAVWEDRRTTCLTLVRDLVATKLDADRSSFPLSICRELALQIVQDLPTSLIDETTLPKFCHIITDASIDVQRMGHRLLHEAARKYTEHLVIEAAVDSETTLRPELPLELVHILQRNLNYEDPVEHDDQQLSGYLLAWMIVFDLFTNASLKVRSGYIDHLRDQSLVSLYFLPSILNILGLYGGILRAFKLDVWAVDEYYLDSYSTDSPLSLRLLAAHLYYRALLVVPSLIRDWLRECKDRQLFNTVTAYTSNYFSPIIVRAELSEVKDPDATADLVDENFTLKTASVVSEVTAAYIVDEYQLEITVKLPSDYPLHGIEIKDTKRLGVAEERWRAWVLGVQQILSFRGGRIVDGFSFFKKNVSSHFEGIPECAICYSIISATDGSLPRKPCRTCKNRFHAGCLFQWFNTSHSSSCPLCRSEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3X6</accession>
    <name>A0A401H3X6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4E type 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1501420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620050.1">
        <property type="nucleotide sequence ID" value="XM_027764249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3X6"/>
    <dbReference type="STRING" id="139825.A0A401H3X6"/>
    <dbReference type="GeneID" id="38786054"/>
    <dbReference type="InParanoid" id="A0A401H3X6"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="46740" checksum="FE78820D7D5A557F" modified="2019-05-08" version="1">MSTPPAVAPVAAPKAERASSGARMPSLNQLAARINLNSSTNPASAASRPRLAAALLRTSSQTSLSTVTSNTDSVAVQPPGSRSVSPANLSASAPHSNSTTPPIPDKGEQLTTERLERLNKETEKKEKVPIGYKNIPSLDAITARLAKARTLSVDGSAKPPEAETIEDPKTPGLRIKAPEHPLEHTWMLYHDSKAKTPFTPATAGAIPEPPQSAFQPPESEEYEAGLTVIGEFDTVESFCRYFNWLKPPSRLERNSNYHLFKSGIKPMWEDPANADGGKWVLTMKNNPQLLDRCWSWLAMALVGEDLDEGDEICGAVVSLRSKVDRIQLWTRTKDDVEKVNSIGRKMVKLLDVSEVDGIGLEFQYNNDDRPVPNKFLSIMALPQSSYRSSFHMKGNSPVSAEGSSGGAPAPGGAFAGFGVGGGGVLGTSGWRGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Z3</accession>
    <name>A0A401H3Z3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1501260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620036.1">
        <property type="nucleotide sequence ID" value="XM_027764235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Z3"/>
    <dbReference type="STRING" id="139825.A0A401H3Z3"/>
    <dbReference type="GeneID" id="38786040"/>
    <dbReference type="InParanoid" id="A0A401H3Z3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59571" checksum="8D8A672F25AD2A11" modified="2019-05-08" version="1">MGTYLIGALTLAFLYIIRRWLEYRGLLRIIRDFPGHRTLLKGFSPMLRWRIPYICPGSDSDIYRKYQDFAECGHDVMAWVNMFPRARVAYDIADAECLKEIVNARAHFVKPVYMYRMLSFFGSNLLITEGYEWKRQRKVVAPVFSERNNKLIWDETIRIVGDLFDNVWGNNERVDVDHAVDITLPLALFVLSGAAFGKPVSWTQGSSVPLGHTMAFKDALHVVSTQIELKMIFPSWALRWGITLKLRKFQQAYEEFSSYMSDMIRERKSDAEKAGGADILSSLVQANEEEFDGDSKLNQGELEGNTFIFLLAGHETTAHSLAFTFGLLALYPDEQEKYYQHLKEYLADGRTPGYEEMGQLTYSLAVLYEALRMYPTTKRVPKVSTEDTTLSTINAGGQKVVIPVPKGTELFTSAFGMPYNPRYWPDPDTYKPARFLGDYNRDAFVPFSVGARACIGRKFTETESVAALTMIIMRYKIELKDEPQFAGESFEQKKARLFTVNSGVTLAPRRLPLVFKRRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H430</accession>
    <name>A0A401H430_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1501800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620085.1">
        <property type="nucleotide sequence ID" value="XM_027764284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H430"/>
    <dbReference type="GeneID" id="38786089"/>
    <dbReference type="InParanoid" id="A0A401H430"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="338" mass="38594" checksum="9720E25E57527AEE" modified="2019-05-08" version="1">MLSAESVESGCSNEDSRPEVPHVCEDEEFWFTDGNVILVSGETSFRVHQGVVSRHSEVFRDLFSVPQPENEEKRFGCPVICLSDSPIDLRYLLRVLYDGRKYYLKRREEQLELAEVAALVGLAQKYQIEDLREDGILRLKTCFTDKFDVWEDILNKSQASYSSTLMRFRPTDAIAAVDLAHRTDTLSMLPIALYLCCTLESSYLIRGVTRADGTVERLSPEDLERCLDARTYLLNRNISMNQQIYGATSPSCSDRSRCSIILERASAHRVMNSVGAKAHHVLRSTDEFAESLVRSFSLCRECLALIKSRDLIARRTVWNELPTFFGLTIPDWNRDIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H469</accession>
    <name>A0A401H469_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1502440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620149.1">
        <property type="nucleotide sequence ID" value="XM_027764348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H469"/>
    <dbReference type="STRING" id="139825.A0A401H469"/>
    <dbReference type="GeneID" id="38786153"/>
    <dbReference type="InParanoid" id="A0A401H469"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="129" mass="15117" checksum="E90FDC6499697E36" modified="2019-05-08" version="1">MTSSETQSPRVDPVQARNWRHDIQKILLSKNPVKPEDVPRAAQLLTEMENCDGMKVEYLEMSKLPKVFRYILMLPPQSIPRESEFKILERIQNLHSCYQILLRGHTQCEEFDKQMSNLAEMTMNIGMHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4B2</accession>
    <name>A0A401H4B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620156.1">
        <property type="nucleotide sequence ID" value="XM_027764355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4B2"/>
    <dbReference type="STRING" id="139825.A0A401H4B2"/>
    <dbReference type="GeneID" id="38786160"/>
    <dbReference type="InParanoid" id="A0A401H4B2"/>
    <dbReference type="OrthoDB" id="3255922at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="538" mass="57361" checksum="E1146A05ED4D31DE" modified="2019-05-08" version="1">MLSSLGFESKNHARNGRNGASKYFEVPRGFSVHVFKNPATASSHTYTPAGGKPNPVHGRPVVRSKPPAYPPRPDNERKNSLIHPSPPADYDAAFVLNRSKPRKNYGIYPSATDNNTYIYERSVSSASDILASSHSSSSSDSDDSISGSAVSTEVSSTRASSSTETLETTALSVRAHVSNAVGAAPSAPLRATPSSGSAGATPDNNGTIPRVPLIVSEETSPRFAALPPTFAVPIHLATVETVSDSDSDTVIDDPIVDITRPRRANAGGRDEGRRDFSVVPSAAALSARRDTDGHSSSQQVSRSRDSPETQQVTTSTALAPAAKCRYEDSSSLRAPPGLAVTTAYDGGDQLRRVAAGSSSHPTSNSSDVRPPQRPPAIPLPVANRTGGISESAPAVLTRIGEGTPHNNRDSPSRTVERDARAESTIPLARATSAFEGGFGTTSRRCVRWTENLVCPSPVPPSERRKGWFNRRGDQLWTNDGRYKSVEAGKDYPPDLVGYPEPNSGWMNENGVRIDMQHHLIPKPPLRSALKRPKASPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4S2</accession>
    <name>A0A401H4S2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620263.1">
        <property type="nucleotide sequence ID" value="XM_027764462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4S2"/>
    <dbReference type="GeneID" id="38786267"/>
    <dbReference type="InParanoid" id="A0A401H4S2"/>
    <dbReference type="OrthoDB" id="3209295at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60866" checksum="E6C8A703F45A5D27" modified="2019-05-08" version="1">MEEVREVSSHVGASSLPPARVRASLKEAAKTLGGSRCLINDLALEVLGMILLYAVEPMDTPSGNMIWPPATLISKFAVEDLKNVCGGWRAICLTMPALCNTIYDNRYSRLEPSVVEAVVKHRTLPLNVCVNRDYPSPAIMKLFQTCGSRVRNLHVYSSRDLSLQLPLRCLEYCTNFQAPALEHLTINGDAFDGGFLTPTLFQGQVLHLKTLSLWNSAWLPANRFNSLTHLFISTSIRQSTRVPSDRNIRWAMRDLLSFISGCPNLEDLLLWNILLGCPPAIDTSAVTLRRLKRFAIGRPSPEHATWLLRHIMCPADSVAIRILNMSCKTNQLRALLPTLPLLDARIAQIQKTFNRLSVSFANGSSAVSIEIDCWPKWNATSWPTLWASWPRLAGVRELYLVGMEVVLTEHFAGIPSLLRQLSALVTLVYCDIGPPDKLLKYLSQTLHGMPCPRLETLHIYRPEDMPVNIVELVEFMEARACAGYKLRRLILEFSAEVPDGLRASVGRLGDLVEIVEVRENGGVGPRAPWPAVCSETTHKSFWPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H602</accession>
    <name>A0A401H602_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1701150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620703.1">
        <property type="nucleotide sequence ID" value="XM_027764902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H602"/>
    <dbReference type="STRING" id="139825.A0A401H602"/>
    <dbReference type="GeneID" id="38786707"/>
    <dbReference type="InParanoid" id="A0A401H602"/>
    <dbReference type="OrthoDB" id="2796784at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="418" mass="45273" checksum="B82DC42EC813D154" modified="2019-05-08" version="1">MSLVAGLDYCGKASMREHLEAVWGAEGGRGEGPDHATPAVALQGLNSPSDGSNGGSHPRDISNTAPALCDFTQAEAALQVCAEGLGPGRNARCQYYFEKRTAARATARAKKKKASAIHVQSMASLSQQKMPGGYIGSRIKSERPPRRKIIGCANGAAAYICDSEGRLIIYRSFAGPATVRANSAAMAAVEYLQHSGVKPTYSSSTRGNFLQYYFTLHRDNQVRPRMSLYYLKHIDVVRELGNLLKPVVALINGIFKSRFPDLYAHYAATLDYVLEKDAGLEALFYPFASFALNAGIVVTLPHLDSTNYGPGLCCIMPYGTFDLAQDCRIGIAKLGYEIEVGPGVPVFIPSAMFTHYNTILISKGMRGSLVFWTGGSIFQWVELGGKMVSELSGPEHEVYIKGLAARILAGLARFPMHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6M7</accession>
    <name>A0A401H6M7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620987.1">
        <property type="nucleotide sequence ID" value="XM_027765186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6M7"/>
    <dbReference type="GeneID" id="38786991"/>
    <dbReference type="InParanoid" id="A0A401H6M7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="1">
        <location>
            <begin position="302"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="467" mass="51208" checksum="0D1D6643861ECAFA" modified="2019-05-08" version="1">MAQALHVNPEHLALHPANQEPDISSAVSYSATEFSAALGPGAAAGASPFGAAGALAGAGGVPGTLPGVLTQGPAFAVAPIMAQGNYPGVLLQVISTAQPASSELQPMVPTGLPDLTIGQHFPQGVNPVAVGSVYFQPLGPNESLLFTPSPGPVLDQPTRMSQLEDWAPVLHGVAYEARDVLLGTIFADDNSDPFATGSPVRSTARETFLDIRARFEDQELRKRNPLSRRLPEQYWASDDIVTLIADSLGNFRSRLKDLTQKLIDIDPINDRNPLPVQMYKSYYLHAPDINADSDGPAPPSLVRQRAITLREHELFMHRGTALPNGRFQHDYSNPVLFRLVERAFYEGNTFGGQHSLARAIDAIYRKYFPNVPDEEVPFRTSIPITAIALCVTVIANVLDQRCETGFFDRIRFHRDRYRTLFTDIRNELYLALQDPAFGPVYHDFLRQHAESFLRGRLLPVPGVDEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H706</accession>
    <name>A0A401H706_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1900530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621117.1">
        <property type="nucleotide sequence ID" value="XM_027765316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H706"/>
    <dbReference type="STRING" id="139825.A0A401H706"/>
    <dbReference type="GeneID" id="38787121"/>
    <dbReference type="InParanoid" id="A0A401H706"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="300" mass="34141" checksum="77934D15B4582223" modified="2019-05-08" version="1">MTPKSASSAVIQPQMDDKWAQHCAAYAEYTHTPWDWLVDLTPIKQEQRLLRQWNFTDAWLLDHLKIGANDTFALCDTKRTDYSFQEFTAFKTTLGRKYQHPQHLSTLAHRPERLQLGTLFSSSRLHRDRGNAIRDELGGMYFDDLDDLDNRAPPYIPPDIPSLRVPHPYLHCPILRALLSSPAQFTCMHQWPAGRSRLPLLHTSLFLATDAVIPWNSTLLVHSTRTFPSTFFLEDFSVQTGALNSPRCARDGVALREFMLSFLEAMVAGRTLDVIGTEGCTFSSFVKTCCGERMMGERSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4P9</accession>
    <name>A0A401G4P9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0100230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608064.1">
        <property type="nucleotide sequence ID" value="XM_027752263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4P9"/>
    <dbReference type="STRING" id="139825.A0A401G4P9"/>
    <dbReference type="GeneID" id="38774068"/>
    <dbReference type="InParanoid" id="A0A401G4P9"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="464" mass="51283" checksum="C19A8AE76699BC86" modified="2019-05-08" version="1">MAMLPGGHYIVASVTDNARSRYSLIIFVMDSTLAGAWVVARTDTFTKAYHLQAKYMTIGGERGIVVAYIRRNYRRFEDMQSGVDISQYSADHEIDSPVPIKYECTRSPLGIPCLDEIFGSPYLAVAKDRNKIVFKKLDGGPAATLHCEPTFVGPIEEHSIAAIRLVSVENKVLVVRKVSQGDPTVTVEYYDVIPPGDEKAEVHASCTNGIIIYGADATWVKISDHGIPPREDDSVVPVLYGRPEAYAPRPISVFIYLSAGRKLLRLSIFPVRDEDVPLPSPSSGPLSHDQAYGAYTYPLKADKEPDWWSFKRYEEEAHVLAGSYRSIVYTTPLGNRTDAPPIVKFHRYFDPWSRWEDPPEGVDMSQKHVVSRTYVPDGVRDIKSVAALAWDETIGRLCVAGAGSPTVHVLDFAAWPVSRETSGGTVRRPVAVQLNPDPDAVLAPLPELPPEEDGEIELMAVDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4R1</accession>
    <name>A0A401G4R1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608045.1">
        <property type="nucleotide sequence ID" value="XM_027752244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4R1"/>
    <dbReference type="GeneID" id="38774049"/>
    <dbReference type="InParanoid" id="A0A401G4R1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="89" mass="9691" checksum="FF95E942B1D2013D" modified="2019-05-08" version="1">MQPAVNLGDTFFLHLALPQAVERHRSAARLLSEVEGYSSPFVVAPATAVRQERVAPFSRSPRPLEASTHPTPPPCTLRRPSPSRAGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Y7</accession>
    <name>A0A401G4Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0100970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608138.1">
        <property type="nucleotide sequence ID" value="XM_027752337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Y7"/>
    <dbReference type="FunCoup" id="A0A401G4Y7">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G4Y7"/>
    <dbReference type="GeneID" id="38774142"/>
    <dbReference type="InParanoid" id="A0A401G4Y7"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE77225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="495" mass="56237" checksum="8C05B144C26C8246" modified="2019-05-08" version="1">MAFQHFGKGTLRVVKNYTHGYSHTQTKVRDVTSNDPWPPSGRAMHEIAQLTYNPVDFVEIMEVMDKRLNDKGKYWRHVFKSLVLLDYLLHSGSENVIMYFRNNLYVIKTLREFQYVDEDDKDQGQNVRQKAKDITNLLMDDKLMQQERRNRAQMYQRMRGRRSADDDDDWDDRSNSRSRSLTPVAGHRHKEDEDLHRALEESKRSVAQERATAEEKDIQRAIKLSQAEEERMAKALAGANSAALFDVQNQLPPTVEGQLIDASLPLQYTSNVQPQYTAFQPQMTSLQPQYTSLQPQFTSVQPQFTAMQPQFTSIQPQFSSFNPWQQQAQEEAMQVEWILQQQAQAQQEEWLRQQQLLQQQQQPLVAQPTAIGSNNPFAHGPSASAPPLQPQQTSSPMSFNLQGTYVNRETAASAPPAPSQPQSTGQRMRADQTHANLADLFAARGDDGSDTFGNAGMLRFGYTQAGRLAAQRTGPASHNPFSLDHLSSQKPLTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G525</accession>
    <name>A0A401G525_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0101340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608174.1">
        <property type="nucleotide sequence ID" value="XM_027752373.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G525"/>
    <dbReference type="GeneID" id="38774178"/>
    <dbReference type="InParanoid" id="A0A401G525"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="485"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="702"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="735"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="888"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="973"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="999"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1141"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1305"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1328"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1425"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1438"/>
            <end position="1448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE77261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1448" mass="155735" checksum="AF075B1EF76FCE70" modified="2019-05-08" version="1">MAMQQAYAHTNKGTLVPGQMIAVNKYTVQVERYLSQGGFAHVYLVRTATPVYNTTHHVLKRIAVPNEAMLTEVKKEVDIMRILKGHPNIVFLIDAAWHRLPDGSFEVFIFMEYCAGGGIIDMMNRRLRERLTEPEILTIFVDVCEGLAAMHALKPPLLHRDLKVENILQSSASSYKLCDFGSATPVQKVPANSQEIRMLEADLNRHTTLQYRAPEMVDVYLRRPIDEKSDVWALGVLLYKLCYYTTPFEEHGPLAILNVQYKIPPYPVYSGQMNALIASMLREFGTQRPSVFEILNHVHKLRGTKSRFTYNIPSREQPLSPRSMQAPPLQAISQNIASPSQPHANALDDLVTFKSQQPLPLSPSKNAGTEARDRVLEAIAPMRRGRPPPSASPVVPTPPASPKKGKFELDMKFSAEEDRAWRGVRGHKSGLASVGMTNVNLNATPGTDAWGLEPRIALKKAPELEAFDNDFSGFGKSFGDYFEPAGSPPVPLTAQPVSIPQPAPSPKPPSASPQTSRFQPARSTKDAFEGLGLTAQLPPQTLGEARKSRTGLASFGLSSSLSANLPATQYLGSGPGTSNTSYRPPSAHSPVPSPFLQQPQSQTLSPDPQPTQSWRQHVRAPSSFMSRGLTPEERFPSVEDLDRTFAPPPAAVSSVGDKIPMAHAQTQPSAANWQPSRASVPGHVRATTDALLGDSGLNVTRAGKGRYDGVRSQHVTGTAMRESRIAARQSMLGRPVEHSRQPEREREAVAPRSGAGLTSRPSIARREKSSVSAKTLDTADLSSVRGDPSLKPSTPTPVLPPRPQPSPRKEPRDWLTGADDDELPPRTPAQQFQPVLRGSPSKRASFIERSPIELAMPLEAENVPEPSYHPRPRKQSKPEKSAGGTGKWDLEKEVEAQMEKDRERERARTKEPKLSRSPRRPTKASVTRTGTGGNIGALGLQLPPVDTNVAAGVTPSPNGLTENWSPVAPSPKPLSKASLSSSSEEGPEDINGFVPRGGSPEKTEEMRKVHEERLTGSSRRRPKSKGRQSSVHDLVDLWGGGVAGEKEEDQENTSGSTSKQTDKRKSVIMPAAGAKPPFLAKPRSESPQPLVDTTTALGRIHLPKSTSPHRRQPSALPVSFALAAPVSAPMAGRSRPQSMFLTSPSKSLTSPSKPLASPSKPLTSPFKPFASPSKPSLVEGVASSSSSAQQTLSPPATPSAKRSMRRSSISDMVQLYEAIGSNQTRGTSAGTGPPAPTVASGPPNVNVATKPAANDTGSTIPSPSAAATRFPKISSDTSPVISKVNLAVPDISGGIGAGREAVRSRPSSTGLPSRTSPTWHLETPYMKSETSNTGTRTEAVNGLPSRRSPLQFPRPLAEEPSDTGVEPPLASPFPERKATIPTATENAVSPGLRSPSPERPYQGVSKLIDRWNRAVDDTSGANASGPRRGGFPARRAGVVGGDSGRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5B7</accession>
    <name>A0A401G5B7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">37S ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0102260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608266.1">
        <property type="nucleotide sequence ID" value="XM_027752465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5B7"/>
    <dbReference type="FunCoup" id="A0A401G5B7">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5B7"/>
    <dbReference type="GeneID" id="38774270"/>
    <dbReference type="InParanoid" id="A0A401G5B7"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="32169" checksum="F802F990DBA4521F" modified="2019-05-08" version="1">MLRAKLTRCPRVVASSSSLPASLLHTSPVLQSFRKRRSRVQEQANLSKRQERERLEQTDRPHIVLGTRPSTPERWENSDLAKILVTEKDILDSPVMPLTPTLEHDIQTPTYYNYGLGAQERELLFETLPVLSVEGTSMRRPMDDPKQLLENHKLADEHERRKTVMLARLVDLRNANARGIAFENRRRIISEFSESGKPNDTGRSEVQAALLTLQIRNLWDHLNKYKKDISNRRSLRRLVHQRAKILKYLKRVDQDRYDNVLERLGLEPESVEGELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5I6</accession>
    <name>A0A401G5I6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription initiation factor TFIID 111 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0102860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608326.1">
        <property type="nucleotide sequence ID" value="XM_027752525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5I6"/>
    <dbReference type="FunCoup" id="A0A401G5I6">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5I6"/>
    <dbReference type="GeneID" id="38774330"/>
    <dbReference type="InParanoid" id="A0A401G5I6"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="5">
        <location>
            <begin position="316"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="771"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="963"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="879"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="963"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118921" checksum="66B9F282CAC7EA0F" modified="2019-05-08" version="1">MAEETDVIATLTGFSLNNVLDGLDLPTGPGLTNQLGISGLSGFSAGQIYNDKWDDADAVGPGEGQDWEDEVDRELEAEESDDGARVKMEIESPKQMTRKGKRKRVIHRRVERPKTVYERFPTFEKDKILDFTELFKGFTVQKSRISKRPFHVETIYPRKKEVPRRFLASIVGDTERQVESKRVEQVVASGSVEHDLRRAMEERENSNVPVSFPLHDRSFDLVLLSNWEDQIIYEPEDDMSAPSSTSPTNLTTPQNKVLESGVWTQSIIWNPRAPFRDFTQLEMNDEDIAAEEKPPSETVRPKKRLRSDAGQPRDKFNLSNDQFYEVSKDGGRHRVRQTFGQLVVEHAYPAQKLQLPFFKTRLSKQEARSFHRPALQFPSNIELHFSKVRTAKKKKDKAGRKVGKGGNVGEGLHRTGDLSLRDTSNFVLWEFSEEHPPIIQNFGMGSILVNYYRKKNEKDEHVPKYDLGEPIVIEPQDESPFMKFGYVYPGQTVNALYNNLMRAPLFRQKAYPTDFLVVRSTTKNDTKYFLREIKNIFVVGQTYPVTEVPGPHSRKITNTIKHRLQIIAFKLLQKSAEERLKISRLMKYFPDQNELQMRQRLKEFMEYHRRGPHQGFWRLKSTWTIPSDADMLKMVSPEQVVLSESMQVGQRHLQDAGYSFNGEVAEDDEGDLSVEQQLAPWITTKNFLFATQAKAMLKLHGEGDPTGRGEAFSFIRVSMKEIFVKAGEDYEQKLAEAESRPKSAHRYNVAEQQQIYKSEIERIWRSQFDSLSRRDEPQLTEEDEKREEKKPQIQSEAYHPTPGPLSPTFSRGSSLARDRETSLAPEAQKRVLRIKRLINGEWKTEIIRDNAVINAYVKRRQAIEEDALTADALAPTGDADKDRRAKKRLEEEIARMKKNQERRLHRKNAKIVKEGGTPMQLNRPVKPDTTRRCGHCGQMGHMKTNRKCPRWAEFNSGAPPLPSIASPSAASPSGSGSFGFGSSDSLFTPGAGNLLRPPTQSLGLGSHGPSPLATSPPMMAMDDDDDDGPPTPSGSGPKIKLTLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6C9</accession>
    <name>A0A401G6C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0106040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608635.1">
        <property type="nucleotide sequence ID" value="XM_027752834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6C9"/>
    <dbReference type="STRING" id="139825.A0A401G6C9"/>
    <dbReference type="GeneID" id="38774639"/>
    <dbReference type="InParanoid" id="A0A401G6C9"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="442" mass="49866" checksum="A92D6A61616965DD" modified="2019-05-08" version="1">MVFYDVSSLGFLHTLLSIQRKSYSPASNTLHVVLVHGASLRSQTFRRWIFKKGWALTSKKFRALDIKSLIPTRSAFSTRLSQFGFNFYSMFVPDLMHEFELGVWKAIFIHLLCILYAAGGDKIQEFNKRFRKVPTFGRDTIRHFSANVSAMKKLAARDFEDILQCIIPVMEGLLPKRHDKIIADLLFELANWHAHAKLRIHTDSTLKSFEKVTTSLAAAGPDIPFGFVSPDEVLRGTHLIPAFAHGKTSKLLPQSIACQESEQNEDWKYHYVNIFVDRDMFMRYLGGGVGHKGAGASQYRMHKENEHCNGQDRGDEDGESQGEYANEEEEGDKVDVDDEDEEDTDGENDDGKEEEEEEEDDDDDDDNEVGEEEGDEEDNIVDLGPEDGEDGNIVGGFGMTLLGNPEHPGSRAIFPDILFSIEGYSSYENYVACSGLVYWCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6I3</accession>
    <name>A0A401G6I3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0106570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608688.1">
        <property type="nucleotide sequence ID" value="XM_027752887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6I3"/>
    <dbReference type="STRING" id="139825.A0A401G6I3"/>
    <dbReference type="GeneID" id="38774692"/>
    <dbReference type="InParanoid" id="A0A401G6I3"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dilute" evidence="2">
        <location>
            <begin position="319"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="894" mass="99798" checksum="349B1E719CAD5F32" modified="2019-05-08" version="1">MASSSLAPIDLTVEPDLQPLYPSPSQTAHLLSPNVGLAPAQKAELVSHCVTRACLFADMTLLSFLLTDSHAQAYVDLTKQDEDGLGLISITILGFGSECDRDIEREECVRLLISEGCDVNVSDQAGWTPLHYASLLAPPTLVSHLLTHGSLSLSLTRRQLTALDIVTAHSTVPGREDVALLLEEAMREAGWKGGRMEQQRRSFEQRRRRLGKKKSVQNDIEKVLGISPRWWGHTEYDVFADLSDEEDGEEQSSSFSFTPTPDYTTMLVFSPQSLPDIFQSLITDFPPSLRNAEPANALYMLARFACLNCDHNWVEDLIIGATDTIEEAFFNRAEDATCLIFWLYNTTVWLHVMRCDDAISGTCEYLGSFALIEEIINSVFVFIIRLAERKIDQLLDAALLDYSPLSSEFESIQFESEWSFLRSFGSKKKAIVNGSSANPPAGRNLPSPKLPSRPPSPSLPSQVSSSPPTTRNFASLRQTFTRARAPSSAAPLQSLFTDTSTPPPPSPRDITSFMTALHTLLTLSGINPSLIVQLWSQVMYWTACETFNRVLTRKKYLCRSRAVQISMNLSVLEEWVGEMQLPRGVVSHFAPVRDLLTWLQSLSSISEFPNLIATIQTLKNLNPLQMRRAVRDYRYEVNEPRMTEECNQYLAQLQKDWERHRVKLGVEALRKEIVERERDRDDNVSRSPSLHDVSIASDSVSVTTSHETSAAQRGIDALFDTTQEKSSWEPMKAPEPLGELLDSRFMLPLLLPSDPRMLGALPVTRTNPDEERRNNARLSLDSTATTTSRGSFGSRGAMAWRLRNRKLREVGVTTLQWIDGSRSAARWTRPVELDEEVEGPPPPYSSDDPQSSHGDLEPALVTHLTPLTRKPSTRSRGRASVGSTPVEPTAVGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6P1</accession>
    <name>A0A401G6P1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0107010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608732.1">
        <property type="nucleotide sequence ID" value="XM_027752931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6P1"/>
    <dbReference type="STRING" id="139825.A0A401G6P1"/>
    <dbReference type="GeneID" id="38774736"/>
    <dbReference type="InParanoid" id="A0A401G6P1"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="93"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="437"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="596" mass="66095" checksum="9DA110A533093380" modified="2019-05-08" version="1">MLSTTSTAPTGVRLTSYRSFCSSTHSRASKSRHAYNVRPPRQDASALLVRYESPEAHPNETFEQIGVPRHISIALRKAFPSVTHPTQTQRELIPAILKGNDVFLKDHTGTGKSFGMLLALLSQRRKAPRDNHGFPITSLVVVPHRDLAYQLLDWMERIHAHLPEKDLAFLVQVLVRNSAISLGDQISRLRQLPPHILIGTPNALVDVLQEDSSALKLPTLSTVVVDEIDYLVESPPLHEDKYKALKIHRRIQKHPGPTRQILDQIYERPKETGPKHGWQPPIEESKQIMTYGMNRPQLVMSSATFRAHSAFLETAAAWLVGRRDRVVRVTGSPDITSETMKHEAAQTLGGKSVRHYVLIVSPEGDIANIEGAEEPCALAEAPNLEVNPRSDIDIDGSTASHSPPDSGLIMSESLEIEPINEFEDMPLPFNHNLLEAIAEAFALDVPRVALLVLPSSAPLKRVVNELRRFGVDARGLDVAGSETGGAYLMDGSAAGAAENPTLLVCTFASTRGLDLPTLSHVFILGAPEDISVESYADLYLHAAGRVGRFGRSGKVINVVEARYWDRKERKWKDQPERIRRVFKRIGIKATKYSHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Q0</accession>
    <name>A0A401G6Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0107280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608759.1">
        <property type="nucleotide sequence ID" value="XM_027752958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6Q0"/>
    <dbReference type="FunCoup" id="A0A401G6Q0">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6Q0"/>
    <dbReference type="GeneID" id="38774763"/>
    <dbReference type="InParanoid" id="A0A401G6Q0"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="9">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="429" mass="46729" checksum="789912CC32227732" modified="2019-05-08" version="1">MDVLSVGSLSDPEPSPRGKSRSRTRTRMNTRKDYIVGICLLLVVVVLWTSSNFLTQGLFEDGYEKPFLVTYLNTSAFALYLLPFVIRRALDRSKTESLHSDRREYRPLAADAEAASETLSSSALESEELNPATTELVPLTIHETAKLAAWFCLLWFIANWSVNAALDYTSVASATILSSMSGFFTLGIGRIFRVEALTIVKIVAVITSFSGVVLVSLSDSSQPQPSGPLPSIVSRRDSSSTFASAPVLGDSLALLSALFYALYVILLKVRIRSESRIDMQLFFGFVGLFNILSCWPIGLVLHFTGIERFELPHSTRAIVALLINMGITLSSDYIYVLAMLKTTPLVVTIGLSLTMPLAVLGDFILQKPAAIQVIIGAVVVLLSFVLVGWEDSQNDEEQDIITGERLGGGTAGSVRLDEEVVLQSEDSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7I5</accession>
    <name>A0A401G7I5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0110180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609048.1">
        <property type="nucleotide sequence ID" value="XM_027753247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7I5"/>
    <dbReference type="FunCoup" id="A0A401G7I5">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7I5"/>
    <dbReference type="GeneID" id="38775052"/>
    <dbReference type="InParanoid" id="A0A401G7I5"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE78135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8499" checksum="86B4B914B0D59B58" modified="2019-05-08" version="1">MAVQELDMITDVFNRLVSSCHAKCISPRYAEGDLNKGESVCIDRCVAKFFEVNKKVGEKLQNMGANAGAAAGGQSAFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G910</accession>
    <name>A0A401G910_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0115400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609564.1">
        <property type="nucleotide sequence ID" value="XM_027753763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G910"/>
    <dbReference type="FunCoup" id="A0A401G910">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G910"/>
    <dbReference type="GeneID" id="38775568"/>
    <dbReference type="InParanoid" id="A0A401G910"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="478" mass="52998" checksum="5B3E512EB44683A1" modified="2019-05-08" version="1">MGFETFLVGYSGSKPIPSLLSIPHVNFLYLSAPPAYLALLPFWLSAPRKVIHQVVSILHALLVSIPNPPEFIVVQNPPSIPTLALVWFVAKIRGSKVIIDWHNLGYSILALKLGERHVFVKIAKWFERYFGRSAYAHLFVTHAMREFLVKEWDLKGHKAVLHDRPPAHFHRASPAEIHELFLRLAPALSTPSLTSFLPPFSPPYSTPFTATPTSSTLTSIPQSPTPDLSELSDTDFALGGAAAPTLRADRPALLVSSTSWTPDEDFRMLLAALEMYERRARARSHEQARERRLPKVLMVVTGKGPLRAKYMRRIEKMQRGDAAQEPWRFVRCISMWLEAEDYPRLLGSADLGISLHSSSSALDLPMKIVDMFGCELPVCALGFACLDELVKDGVNGLIFNDAAQLADQLETLLTSYPSSHALATLRASLEQTPAAGTPSDGQRRASGAEHWEWGTWSQNWNSVVRPLVLSDVGGGDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G945</accession>
    <name>A0A401G945_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0115730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609595.1">
        <property type="nucleotide sequence ID" value="XM_027753794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G945"/>
    <dbReference type="GeneID" id="38775599"/>
    <dbReference type="InParanoid" id="A0A401G945"/>
    <dbReference type="OrthoDB" id="2803918at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="484" mass="52904" checksum="6E6FD70036ACF234" modified="2019-05-08" version="1">MSRSQPTPAESLRITIALAALRFKPPEQPYHAYVLDLRTKFPEDQLRSSEQDIWRERALQLEESLKELQIKYDCEHIELVSLREAQPRQSSEAPVEPPASAGNKKKQKKKVPAHVSPVSSLKAKPLKFTLQTVLNGAGNAVSVPPGPSTKSLLSALETLDLWLAVHAANKAVLPAASLTAMVARAIDALGALFVSVVPPNHIISSSVGSLEALTTLVPRLLTAVLPLPDRGGRKQKTKSSENLAVLDDVLGRLTTAILVPLVRSFAPLSRFHLSTLLSPERNKQKRSQAHNRHEVIDIRAETLALLKATIITLDELMTTTMLSAPSIHNLKHLLVLEALRELQSLYPESYASPDGVQGAASTAWARPRLTERIERLIRKDTLWYLCNVLHLMFATTPHIRSPAPVDLPDESDGSHGLLEEAVYAGLSALLRGTRPQAQRPDAEEGDRGPAASDGSAKAPWRGSVMGEVERGMLLAVVERVWLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9N8</accession>
    <name>A0A401G9N8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609795.1">
        <property type="nucleotide sequence ID" value="XM_027753994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9N8"/>
    <dbReference type="GeneID" id="38775799"/>
    <dbReference type="InParanoid" id="A0A401G9N8"/>
    <dbReference type="OrthoDB" id="2690981at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="20981" checksum="7A6A1E0A600B7F80" modified="2019-05-08" version="1">MAQASHARWSHERLGRLIKFPPRYENSLYGPLNAIFADIFSPSRGFIICPQPIVQERTIIESHPAAPSTASGPSFIDPVLETNPESVKIWIPDFIIVKGREVMGTASDLVLALIEVKNNAAKRDAYMRQVTNYLDALPIETCSNGFVAYLIMGGETVIWRSEGQGANRTRVRGSVAIHTGGRAFLSGLSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAN8</accession>
    <name>A0A401GAN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0204220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610138.1">
        <property type="nucleotide sequence ID" value="XM_027754337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAN8"/>
    <dbReference type="GeneID" id="38776142"/>
    <dbReference type="InParanoid" id="A0A401GAN8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="33054" checksum="148D4BAEAAF91B7A" modified="2019-05-08" version="1">MSSESWLAAVDAVYFIPGMVLFVETMHTYYADRIDGQRMEVFCKAAKAELDNVDHYFSRLPPGSEAFQKAATIYPELLTHMKPRFENIRRDVMDSLNVLVPLLYRKQFSARDFQHPSIPSESWRAAVDAMYYIPGRIIFLEAMHGYYARCQADCSGDYGKMLQHLCKSTWVELEKVDYYFSRIPPGSEASCKAEMLRPGLLSQLRPRVEDLRQQITHLEERYIPWWNRKHGDALRQQNGNQDLEHLLLSIETLTLREADKDRVEKRIPLFEVSDPHGKTHIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBG4</accession>
    <name>A0A401GBG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0207050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610418.1">
        <property type="nucleotide sequence ID" value="XM_027754617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBG4"/>
    <dbReference type="GeneID" id="38776422"/>
    <dbReference type="InParanoid" id="A0A401GBG4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="247" mass="26916" checksum="B103F42B06D3AEE9" modified="2019-05-08" version="1">MTSITPTSLLCPQDISSIDRAAADALTRLSITSTPSPSPHFHSLRSSSSQEAPKTTTSVLIADAGAMPGPLCEGPLGMPIQVKGETLYHVEQVRETGMTDHWYKAAAATQFYQNAKLHSFHPLLSTPLKLRCTRKAEKKAVQRRGEKTYVMFRGLAPGPGVYETCDTNRDEVKAMCIGVSGSLYQQALIVLLPPSAQLKQIPYDCTNIQLLFHVGRKLLESGIRVAKSYRATIVHAVAFGAAVPRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC66</accession>
    <name>A0A401GC66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0209530</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610665.1">
        <property type="nucleotide sequence ID" value="XM_027754864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC66"/>
    <dbReference type="STRING" id="139825.A0A401GC66"/>
    <dbReference type="GeneID" id="38776669"/>
    <dbReference type="InParanoid" id="A0A401GC66"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051878">
        <property type="entry name" value="ZNRF_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNRF1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46661:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE79752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="127" mass="13680" checksum="FBF7F8E84E81C0C3" modified="2019-05-08" version="1">MERIVVDQQRLSLPSSNGNRQSSSQLSDLAECPVCNTNLADLGPASEQEAHVKNCLEGGSGTSPQLAKYLVYKLPAQSTLIGIECAICLEEFLVGSTVARLSCLCTFHNACLSSWLQRGRSCPVHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCP9</accession>
    <name>A0A401GCP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0211270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610838.1">
        <property type="nucleotide sequence ID" value="XM_027755037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCP9"/>
    <dbReference type="FunCoup" id="A0A401GCP9">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCP9"/>
    <dbReference type="GeneID" id="38776842"/>
    <dbReference type="InParanoid" id="A0A401GCP9"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="13"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="318"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE79925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="499" mass="54136" checksum="400EDA9BD0FC3D93" modified="2019-05-08" version="1">MATSSSKPACKHLVLDAGPLLSLSPLRGLAETYYTVPQVLDELKDKHAREHFERLGLSAGVRIEVKGPDTASLAYVIQFAKKTGDYSVLSHADLCILALTYGLDAQEEAMANELSEKETVSSSGPSTSEPEPQDATEKAEPVDDEIVEQPPESGLSSSEENDIVEDPQHLLDDTRVEEEAKDDAAEQEPLDVELHKIEDETCVQNDTANTSTAPEPLPSPSRASDPAPPASSQRSDTPPLYADPSDSDDGEGEWVTPSNVALHKSRALDLLPSADGTRRKGKDKQETIPVGCMTADFAMQNVLLQMGLGLVGVEGRRIERVKSWVLRCHACFKICKDSSRKFCPSCGNPTLLRASVTISSPNANADTPAMRVHLKKNFQYKTRGTIYSIPAPKPGSAKTGPGEGLILREDQTAWVRAKKRADGKRDREERRLLNAASRGAQMGEGGAVLGSWMDPDWVPEILSTGTGGKGRTMRSRGMDGDMPVIGYGKKNPNERRRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCZ7</accession>
    <name>A0A401GCZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylglutaconyl-CoA hydratase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0212130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610924.1">
        <property type="nucleotide sequence ID" value="XM_027755123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCZ7"/>
    <dbReference type="STRING" id="139825.A0A401GCZ7"/>
    <dbReference type="GeneID" id="38776928"/>
    <dbReference type="InParanoid" id="A0A401GCZ7"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000009">
        <property type="entry name" value="Carnitinyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31071" checksum="1EFCA09C6BA28FA4" modified="2019-05-08" version="1">MLVTVLRRSALSARRLAYRRLIHASADAEAYLEPIKSHPGVTCLLFNRPKARNAISLRLLKEFRGCLDTVQFDNSVRVLIVRSSTPGSFCAGADLIERRSMTKPQVDKFLVDLRGALGTLESLPMPTIAAIDGPALGGGLELALACDLRVAGHTVTKIGLPETRLGIIPGAGGTQRITRLLGVSKAKSLIFTARTLSGPEAEACGLVDYVSAPDATAFDRSLLLAEEISANAPLALRAAKQAISRAPELGLESGLDFERASYEPLLKSKDRTEALEAFREKRPPVFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD85</accession>
    <name>A0A401GD85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0213520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611062.1">
        <property type="nucleotide sequence ID" value="XM_027755261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD85"/>
    <dbReference type="STRING" id="139825.A0A401GD85"/>
    <dbReference type="GeneID" id="38777066"/>
    <dbReference type="InParanoid" id="A0A401GD85"/>
    <dbReference type="OrthoDB" id="2757691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1006" mass="110981" checksum="BA60240D5A00472F" modified="2019-05-08" version="1">MPSQGPPPSVGGKDLSSFLPDESGSGGGTASLPNPAQMALFQENRERQARNAARAVRRQGGEDGVSDDEELGMLDGSDGASPGQLDSQEPSAMPAGMPSRPRTPEDDTDSLQLLRDVMKMTPNSRGIALKLWNAGVDKRSGAGPRAEATAGSGSKGSENALITIDSEIKTDLFAGRVVETPQELPALLRNGFHLPLSMCTSEVMTKMHKHPEQVQYRKMHDGKGIKRALIDIAQWPDEQMLKPEDWRDAWRNYFEILPAVCDDEIVKRFSEHYMWLSGQSDFNRIFPVILAFDIDVRRGYFLTKKTFVVDSKSYNDHFLKIRLEHIEKGTRSTLPIPAAPIAGSSQTLYRTPSHSPDSRRPRRDGTADSTAKPFREGRASASTSMLCLICGESGHRASQCGRSTLSNGKPAFTVWENKKLLAISTRAEICLTWNVQHADTSAPSAVPTVMPLRLSGASERERIITPYDADAFESILRTLGLLQRYPFLPRKLRYGFPIGDFAPLLRTFAPSNHSSGSEHIDFIRQYISEQVSLGRMTGPYSQAQVEHILGTFFVSSPLAVVPKAGSKKFRLVQNCSYQDEFGVSVNSQINSDDFPTKWGTAAEVAEIIVNAPSGAQAACLDIDSAFRNLPIKPAHKPFLVIQCDPGNFYIDHVLPFGVSSGTGVQGEPMDAIVNILGAHDIGPSRKWVDDLITFRFPVDQLATSDVRKYAYGLADIFRITDPLGVPWHQTKYSDYASRAVYSGFLWDLDQRSVALPDEKHSKYLAKLTAFIATAERGRVSQRDAMSINGTLSHITFVYPHGRAFLTNLCSFIASFSNPYAPRFAPHSVLSDMKWWFSVLNVPSIARSLASRGPLQDLGIWVDASSSWGIGIIVCGEWSAWHWQGPINTWKGQGRDIGWAEMVAVELAIRTVDALGYHDATILVRGDNKGVEGAFARGRSHNFQVNSSIRRAEVIAMSLNILFIVRYVNTKDNLADPVSRGDPTPSMSHRQPPFQLPEELVSFLVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD98</accession>
    <name>A0A401GD98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0213400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611050.1">
        <property type="nucleotide sequence ID" value="XM_027755249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD98"/>
    <dbReference type="GeneID" id="38777054"/>
    <dbReference type="InParanoid" id="A0A401GD98"/>
    <dbReference type="OrthoDB" id="3295430at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="195" mass="22243" checksum="DDA54B052AE3E0DB" modified="2019-05-08" version="1">MPTLRQRLPTRYRFIINVEKAAQVTLVHNPRLYAKAERDGMHNWVDILVDYTVAKVSREVPIPELFAGNAWIGSGHSSLCWILPMRMLPQYCTPEDEWQLRKFQKMVGLGGNPVIMVSCNGVEPARYKTMETPEFLIEWSLLSFTEHCMSGELTVEKLLASYHGLEMPDVQSLSLEDASKPLVTAKMEKTDDEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDD4</accession>
    <name>A0A401GDD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0213360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611046.1">
        <property type="nucleotide sequence ID" value="XM_027755245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDD4"/>
    <dbReference type="GeneID" id="38777050"/>
    <dbReference type="InParanoid" id="A0A401GDD4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11141" checksum="E78196A4E7029836" modified="2019-05-08" version="1">MGRGSSCMWNKLVRIHRERPALSYGIRVALFSGESELAIGGRADEVDEVDEPERQTGSPNSVRKTWTCGGRIARTSAGPAVQRLLIPSPIHVSVDVAGKSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDN3</accession>
    <name>A0A401GDN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0214990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611193.1">
        <property type="nucleotide sequence ID" value="XM_027755392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDN3"/>
    <dbReference type="STRING" id="139825.A0A401GDN3"/>
    <dbReference type="GeneID" id="38777197"/>
    <dbReference type="InParanoid" id="A0A401GDN3"/>
    <dbReference type="OrthoDB" id="2418900at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="27060" checksum="D599E9E17990DDFD" modified="2019-05-08" version="1">MQPVEPLRAWPSTTATQHVSVEVDEGYDTDAEPEDTDVLPQSVVSDDAEPVHKLAKTCPKPRMSVEHLQNAHGAVDFLPALTSFLQKHLPHNTIKPAAQDRFNVYNQVVVQMPFNPHISDKHSRMRIRAVPSIPPSSTGRKPGSPSHFDMALVCTDPIKKRGFQGLRVGQVRAIFHLPHQFGHYPHPLAYVEWFTEFRPQPDRAVNMYQVSRSTRNRGRNAEIVHVDDLMRPCHLVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDT2</accession>
    <name>A0A401GDT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0215040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611198.1">
        <property type="nucleotide sequence ID" value="XM_027755397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDT2"/>
    <dbReference type="GeneID" id="38777202"/>
    <dbReference type="InParanoid" id="A0A401GDT2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="6172" checksum="364BB2C5253DC83F" modified="2019-05-08" version="1">MSKYLYAIYERLYVVYECRYNRNTNTSNVKCPYVAYDTLPLKQMAIQDDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE75</accession>
    <name>A0A401GE75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0301400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611338.1">
        <property type="nucleotide sequence ID" value="XM_027755537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE75"/>
    <dbReference type="STRING" id="139825.A0A401GE75"/>
    <dbReference type="GeneID" id="38777342"/>
    <dbReference type="InParanoid" id="A0A401GE75"/>
    <dbReference type="OrthoDB" id="2576496at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="304" mass="34245" checksum="C03678183B1EFFA1" modified="2019-05-08" version="1">MRLISPSKIPPLAVVLSLESIIGITKEVVQPIPISCEWGICKAELNSWSALFHHMQLHLQAARNKDRGFECCFQKCTGRIQGTYSDLESHVELSHLVRVHLPCPVQGCSQVFARHGQVSIHFQEDHPHLIDKTVPFKSHVLKSMRQPSRIHIAQLAPIPSEMTELFHLLSYPVARACKRAQRLSQESRISRKWSRMMASQDTEDSADAQPFDNLTKFEPPANFNDFIVWRKPSEPAMQLSRPQFISVPSIPEVPPLLSMSYKAFFAKFKELEKAGLVDGTGEWPESDEGEDVILPGPGPQPEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEH4</accession>
    <name>A0A401GEH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0302940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611492.1">
        <property type="nucleotide sequence ID" value="XM_027755691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEH4"/>
    <dbReference type="FunCoup" id="A0A401GEH4">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEH4"/>
    <dbReference type="GeneID" id="38777496"/>
    <dbReference type="InParanoid" id="A0A401GEH4"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="131" mass="15291" checksum="0F5AC9E56011CA80" modified="2019-05-08" version="1">MRMLSQDDEHDDAAEVTWEDQQRINSFSKLNNRLRGIQEKVEALKQEKEAFDDLSMEFELADEDELVMYKVGEAFIHLPHGRAVKRLERDQEAVDSELSKLTERASECEKSMKELKVILYAKFGRAINLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEY6</accession>
    <name>A0A401GEY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0304570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611651.1">
        <property type="nucleotide sequence ID" value="XM_027755850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEY6"/>
    <dbReference type="FunCoup" id="A0A401GEY6">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEY6"/>
    <dbReference type="GeneID" id="38777655"/>
    <dbReference type="InParanoid" id="A0A401GEY6"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE80738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="664" mass="72025" checksum="4DE5323E109DDBE6" modified="2019-05-08" version="1">MLAARCLRSVARTGNYARIPRSLIARNMNSKVNGPVIGIDLGTTNSCVSVMEGKTSRVIENSEGARTTPSVVAFTKHGERLVGLPAKRQAVVNSHNTVFAFKRLIGRQFNDAEVKEDMQHWPFKVVPKPDGRPAVEVDNGGKKQIFSAEELSSMVLVKMRETAEQYLNKKVNHAVVTVPAYFNDAQRQATKDAGQIAGLDVLRVINEPTAAALAYGLDRVESAVIAVYDLGGGTFDISILEMQKGVFEVKSTNGDTHLGGEDFDIVLVKHILDEFKKENGQDLGQDPMAIQRIREAAEKAKIELSSTSQTEINLPFITANASGPKHINLKILRSQFESLVAPLIQRTVEPCKKALADAGVKANEVNEVILVGGMTRMPRVVDTVKSVFGREPSKGVNPDEAVAIGASIQGGVLAGHVTDILLLDVTPLSLGIETLGGIMTKLIQRNTTIPTKKTQTFSTAADGQTAIEVKIHQGERELVRDNKLLGNFNLVGIPPAPKGVPQIDITFDIDADGIVHVTAKDKATNKDQSMTIASSSGLSDKDIERMVSDAEQYAETDKARKNVIEEANKADSVCSDTEKAMNEFKDQLDATEKEKVVKLVAELREIAVKGQAGDASVTAEAIKEKIGEAQQASLGLFQKVYEKRNQDNANSEPAEEKKDEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF09</accession>
    <name>A0A401GF09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0304860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611680.1">
        <property type="nucleotide sequence ID" value="XM_027755879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF09"/>
    <dbReference type="STRING" id="139825.A0A401GF09"/>
    <dbReference type="GeneID" id="38777684"/>
    <dbReference type="InParanoid" id="A0A401GF09"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="264" mass="28595" checksum="145A1077A0A84F06" modified="2019-05-08" version="1">MTTNAPRRVLMLHGYAQSATIFGKRMGAVRKTCGKDIDFVFIDGPLVLSPVDIAKAFSTSVEESGASEASTQDPALAPRGWWRAEPGSRQTFGLEDSLTLLRDVLQKDHYDGVFGFSQGAAMAALLAALLERPDVYPPFLVNGQAPHPPFQYCVSVAGFRPTGPLCDSIFQSSYATPTLHILGKTDIVVTEERSKHLLELSTNKRVEYHDGGHFVPSKANWRNFLRSYLRGPLGDVPSPSPMSQPASGVATPLSEGLPATHEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF32</accession>
    <name>A0A401GF32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit tim16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0304320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611626.1">
        <property type="nucleotide sequence ID" value="XM_027755825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF32"/>
    <dbReference type="FunCoup" id="A0A401GF32">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GF32"/>
    <dbReference type="GeneID" id="38777630"/>
    <dbReference type="InParanoid" id="A0A401GF32"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE80713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="163" mass="17227" checksum="761ABEFA92256FA0" modified="2019-05-08" version="1">MSSPKIIVQIAIAGAQILGKAFVAAGRQAIQNAKHRPQAALGGDAAGVQNATSGSHTDRLTREHRMALDEARLILNVKKDDPAELLHQRYEHLFRANSPPPLPPKPPGSGTGRAQPGPAHSHYLQSKVVRALQRLQAEASTGEHPTPPPPPPPSSNPPPPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFD3</accession>
    <name>A0A401GFD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cation-transporting P-type ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0305330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611726.1">
        <property type="nucleotide sequence ID" value="XM_027755925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFD3"/>
    <dbReference type="GeneID" id="38777730"/>
    <dbReference type="InParanoid" id="A0A401GFD3"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="8062" checksum="23015534BFD31DC0" modified="2019-05-08" version="1">MLVATVSVSFLVQLALIYVPFMQSIFQTEALGIVDLATLLGLAAVSMGLHDARRRYERSLNASLTYANVAEEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFE7</accession>
    <name>A0A401GFE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0306290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611821.1">
        <property type="nucleotide sequence ID" value="XM_027756020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFE7"/>
    <dbReference type="STRING" id="139825.A0A401GFE7"/>
    <dbReference type="GeneID" id="38777825"/>
    <dbReference type="InParanoid" id="A0A401GFE7"/>
    <dbReference type="OrthoDB" id="2848852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="185" mass="20001" checksum="6860765C8711C854" modified="2019-05-08" version="1">MSSSIASVQPSASAEAPTATKSNNTPIAIGVSIGVVTFLTLLGIGYWTLRRRRFHAPVHGFHRHTSSVVDPSDLACRVTPFGSPGGEQPRFVHNPGENMRVAHRRSDGGWEFSDVEQDPLTPADFTPPPRLSGSTRSSLSPSAKDKLKPGELTTRGFAELDADNNPPPAYHAECSSLSEYQECFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG25</accession>
    <name>A0A401GG25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC1 family protein MCP2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0308000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611988.1">
        <property type="nucleotide sequence ID" value="XM_027756187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG25"/>
    <dbReference type="FunCoup" id="A0A401GG25">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GG25"/>
    <dbReference type="GeneID" id="38777992"/>
    <dbReference type="InParanoid" id="A0A401GG25"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="164"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="624" mass="70899" checksum="1425F38B018C44D5" modified="2019-05-08" version="1">MLFLGRSCLHRRAWQLFVREGGKTRRPLLQGSRVQSTKAPEHPRQTRRISPWVIYPTTIVVAAGAGVFTYENYQPFRHFTLAAVRCSRVARAVVLGAIDYKATFAKTYASEEILLDAYSQCHKRSAERVLKALLANGGIFIKLGQHIASLVVLPKEWTSTMRPLEDQCEPTPYENLEKLFLSDMGQPISEYFEDFDPEPIGVASLAQVHVAQWRNTGETVAVKIQHPHLAEFCEIDMEMVEVSLGWIKHLFPDFEFTWLGEEMRENLPKEMDFVHEANNALRAVDDFKDIQTSMYIPRVLQAKNRVLIMEYIRGARVDDLPYLAVHSIDRNKVALELARIFSQMVHINGWFHADPHPGNLLIRPAPLGSKSPYNFEIVLLDHGLYFDLDPEFRINYSKLWLALIAPATPSVRADRMKYAKLVGNIDSDLYPVFEAAITGRAALESSWSDLNDPSDGASFARGSSMIDLSAQTEEEMEAIREAVVQKEGLLLSVFDVLRRVPRRVLMVLKLNELTRSLDRALATTHSNIRVFLIMAKSCTAAVWQDNKQRLISEMWKPSKGLTSLGLLYEYFRDYWGYRKMYTSLVLAETWMDVEASLVKFKAWLWGLFVVGGLQGAHKAAAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGC2</accession>
    <name>A0A401GGC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0309570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612143.1">
        <property type="nucleotide sequence ID" value="XM_027756342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGC2"/>
    <dbReference type="STRING" id="139825.A0A401GGC2"/>
    <dbReference type="GeneID" id="38778147"/>
    <dbReference type="InParanoid" id="A0A401GGC2"/>
    <dbReference type="OrthoDB" id="2409325at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="538" mass="57101" checksum="8F580D7E8B1E23BA" modified="2019-05-08" version="1">MSDTATTPTLRIVPGAPPPPPLSKSQKKKRKIAKSKSSDPTNDELLTPTTAALVEQAPTESDIKEGSVAPELVVQPETEQISADDAQKPSPIVELLNKRSKAVSKKITRIQAYSSEPLEKLNEDQKKTLLTLPGLEAVQKELEEVKKAIASHEAEVAREQAAKRAEAARAEKQRLAEAVSAAETAHRQKISDLFTFLRLHSLLSSGHPTALALSLNDAEGLAVYSATESLLGEVTDSRPDVIQGFLTGEGELHGVPYSRLIEITHAYMNPPSAAQEEPPQEPVEETLTEAVEEPEVTVTGLSSTLPSTIGTSGSFHFMQEDELEQPGEPNFEGEAEWVERADISGEQNPQTAPEVEVVETVVETNGHVVVEESVSVSTSVKIPASAGNQPINWADEDEGELPPIAGLHAKFGTSGKATPVPAPEPEAVQPPPAERPPVNGGHINGAGAGAHEDDGFTPMRGRGRGRGGFRGERGERGSFRGRGGDRGGYRGGYRGGERGGFRGRPGGEWRGGDGEHRGRGGRGRGRGFGEARGGAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGL6</accession>
    <name>A0A401GGL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612188.1">
        <property type="nucleotide sequence ID" value="XM_027756387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGL6"/>
    <dbReference type="GeneID" id="38778192"/>
    <dbReference type="InParanoid" id="A0A401GGL6"/>
    <dbReference type="OrthoDB" id="3171382at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="311" mass="35954" checksum="6CC4F0F7F8FB8EF8" modified="2019-05-08" version="1">MSPSSPSSGSSSSPIDTNSPPPQPLRIWWTAFPSIKIIRPPKGRFSPQVDERCFTYCSQSIRGRLDKSEPWCRTICVRRVFSHEVQRIISVHEGQEQIAQMKYPLPPEGQRTPSLTGMLSGQPNEENEPRQTEVRHWNEGWYLWSSKSRWAAQERMDLMMCDIERQAEWQRYKEEMNEKWTHHGGEQAIHQSAGHEELESLPDVPPELNNVEHIPQKPFPDLADQSILIPIPFPSSVPPFQHQIENLLTPTHKVLGLLYQTVDSGEQWGFAKRIWEKAWTPEPFVLARNVCTKMWEKWKDGPPDDSSDTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGQ6</accession>
    <name>A0A401GGQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612214.1">
        <property type="nucleotide sequence ID" value="XM_027756413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGQ6"/>
    <dbReference type="STRING" id="139825.A0A401GGQ6"/>
    <dbReference type="GeneID" id="38778218"/>
    <dbReference type="InParanoid" id="A0A401GGQ6"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19101">
        <property type="entry name" value="AKR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="319" mass="35555" checksum="73FA0D55817089F5" modified="2019-05-08" version="1">MPGEALRRPRFAAKWLCTQSSVTPHLTCRTPPSLQADHYGSSEIIFGQFRQNLPHPESVVGATKWCVFRPTNPTRAVVEAAVQERLDRMQAQRVDLLQFHWQDYSDKGYLTALRYLQDLQAEGKIATIGLCNFDTIRTDEICTELGPGSIVSNQIQFSLIDTRPLHGMADVCGKHGIKLLTYGTLCGGFLADKWFHKAEPDLYSGNLTPSQRKYLDMILKAWGDWSLFQSLLSVLRDIGDRHGGVSIANVATRWVLDHPCVGAVIIGARMGLSEHTDDNQKVFALQLTNADKAAIEVVLERSNGRRLITTIGDCGAEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH20</accession>
    <name>A0A401GH20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612338.1">
        <property type="nucleotide sequence ID" value="XM_027756537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH20"/>
    <dbReference type="STRING" id="139825.A0A401GH20"/>
    <dbReference type="GeneID" id="38778342"/>
    <dbReference type="InParanoid" id="A0A401GH20"/>
    <dbReference type="OrthoDB" id="3883941at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="468" mass="50867" checksum="D3DB2351464FB9F2" modified="2019-05-08" version="1">MNTPFPPSTITSTDSLVAVTLIIMLASSRLPIVRASNANSARLATCRIAGRQTASKTYSTVSTQSSSSSAIWSHVGAGVAGGTVVVAGGYVWYHFSGAKQALDASNAVQEYYAKTKRAIVENAPKNPNDVLTFLRSTVKLYAGFIPGASSYVDATFDSLDELHDTHRGEVDKILGHAYDEVKGILKQRKEGSDVETGMKVLEVVKRRMGELQGVGKKVGQDVMQNLGDKFPQVSETLGGGYNELKNMAEKMGPEAKKIFDDTTCQVKDIFSKGFSPERLNQAKELIQAKTEAVRKLAETSSQGAWNKAVQQAEPYLDKLPEIKHLLNENASKFIAAGSGSSTVAQEVLARVREAAEAGVSGNEEKMRELRNFVSKKASQAENDGRGSIEKGWDALQQWIKTVPGGEDALEKTPEVKTFIQLSRERSDDAQKLTHETYEAVLKVLEEKGQKAKKLIGKSEEDVTEETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHI0</accession>
    <name>A0A401GHI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0312940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612478.1">
        <property type="nucleotide sequence ID" value="XM_027756677.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHI0"/>
    <dbReference type="GeneID" id="38778482"/>
    <dbReference type="InParanoid" id="A0A401GHI0"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
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    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sec7_C_sf"/>
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    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_19"/>
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    <dbReference type="Pfam" id="PF01369">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1148"/>
            <end position="1348"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
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            <begin position="280"/>
            <end position="361"/>
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            <begin position="402"/>
            <end position="440"/>
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            <begin position="488"/>
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            <begin position="762"/>
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            <begin position="888"/>
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            <begin position="936"/>
            <end position="1041"/>
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            <begin position="1562"/>
            <end position="1637"/>
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        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
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    </feature>
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            <begin position="137"/>
            <end position="158"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
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    </feature>
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        <location>
            <begin position="427"/>
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            <begin position="515"/>
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            <begin position="1003"/>
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            <begin position="1562"/>
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        <location>
            <begin position="1599"/>
            <end position="1613"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81565.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1683" mass="183411" checksum="C7B1E512A1434621" modified="2019-05-08" version="1">MDLSSVAEQRATAVAKLKRAASLPRMKDGRRPPMHVEAVSEGERVQNDDRKDDESAQESDGRPEPLIATVVLQTQAEAEAVNGVKIEAAAKTEEAEFPSPETPVVAESMPVRAKRRSRSRTRSRGSKDLKGKAKQSPHVSSASHTNESSADEYYTTQGEDAPPSPPLVSPIPSHFGFSAARLLSSPLFYPGTSPSTPLPSLDELQKGIGMGLYRSNSAGAARAMAMQKLTGGKEPMDISFIPSSPTPSGGRLTRNNTFAGGERMAARRLMLHRLGNRIKEADGDQTSGGEEAAPPTLPPKRRRRRSKRNSSRASTVVDDREEREPPSTTSPTPVLPPSPLPPPMDDIPDPPHLPSPMNRVGNGDAVLASPFMKANGNISFDYATPMGHRGVVVEDEDDLPEHVSPVRHSNLPTTPARSYGGTRLPHTSDAPSNTSTDSASASAIGVPVFLSRSAALRQDMMFPASPFATPLREKPYLDEDEEQVLYEEVGSLSRERESEISWIAEPVPERMPLRDDEEDDDDIPEPEPEEEVLQEPPPEPSEGRLSREYERVPPRPSVSQDLVVELETSPETTPSHIPPSPASPIALLGPTISESPTGAEASPAMYPMRLSVATTNPVERSPSTAEFPEPDWDENSRATVTDATIKRAADTSTSTWEKVKNTFSRSGSASNRRSRTNSIGIRDRRNNTDSSVSRESGASLKGDKTDGSGPLSPQGQSLVVHSPSASMLSLPSPPPPVSISPLPPASPFDMMKYADSKLFPFPGMKQLEEQRNRAKGLSQSSSSPDVVLPNGTGIEAVPSSSSSSTATRFPDTNRERKLSHQASDTRLLAQFRTVASPPPVSSVPSSASQADYFTTQSQTSTTSVAGSLKLPMNREGVKKWLTAKKLFSPSVPSTPNVHAPPPVAETRPGLAGKKPSLSDLLLGRKENELATEWEDLGAGRLGRSPKESSIEVRMETDVRTSHDHATEQAPSSRMDSDIHVGNHHAPSPSQTFEVLPPDPPSSTTPDPQSSLDDFPTQSTSESFCDTLSSSHHSPDPPAKEPGEAAIIMDRLDEMLERGSKNSFWPTVIDDPPRKLIQCSPVLQVANANTVKDRFLFLFNDILVIAKPVLQDQDAMLDTLKPSPSDKKYIVKSVVRLSELRFSGDRDESGSKAPSHATPMKHSVIRSFVHQFAKDPDHAIATLFSKAETRDDPVALGQLLFHTLELDRARLGEYLSRRTSKVVLKAYVDSFGLTGLRIDKALRVFLLAISIPPKLSALEHLLDAFASRWYEANVGVVAYDKELAIRLVRAIVQLNEVMHSGIAQEPGITGYPRRNIITRDFVEAFRRFDPRYLVSDDLLDKIYASIRREKLSQARHPSSQSIHPDILITIKRPLPPRLTYRVQSDPVILRIPQVDPQLTIQLFGQDLAFDPPVLTFAKSAEASFRVTGTSLGSKTVIMWRSGPTALAYSGFPLSSPLVVERAFMRNTFQLAFVNHNGAKRKYMFSVDDHLVRHHWTVSLKQQIESASSPAPSTDIPGTSSKAQKINENLAFKVLQETLIGTDGHEHPSEPISPVDEALARLTGTSPQHHPNESASSDRAAGDLPVASSSRKRANGSSVHVRSKSRSQVYHRHGPGKLESELNDSAGDDDYKGFAGSSQQLRPEGRLWRGRDLELVCRQNSLIPSILAYLQVGRIDHDGANGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHK3</accession>
    <name>A0A401GHK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0400370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612579.1">
        <property type="nucleotide sequence ID" value="XM_027756778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHK3"/>
    <dbReference type="GeneID" id="38778583"/>
    <dbReference type="InParanoid" id="A0A401GHK3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="115" mass="12788" checksum="1AE3D34FB8D3AE34" modified="2019-05-08" version="1">MVFLSPHRLESTEQSRQDVMPQAMLRLFTEMADYTLRAFGDVHTPLSPAIPLCGVACFLTLRAEIPGIDSCRTLASVDMVRASIIFRSSNCSSPLAQHAILPESVRQHRAPRRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHT5</accession>
    <name>A0A401GHT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">White collar 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0400890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027756830.1"/>
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    <dbReference type="OrthoDB" id="2162994at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="278"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36831" checksum="85DDDE337A425139" modified="2019-05-08" version="1">MSLAQAIPQAGPSNSAPKQKEPQTFEFTKRKRWADLLITELSDAIILVLNATGKVWYCGAAVTELLGWRDEELVDGDLVNLMNVDDRASFRTMFADCLHTRRPLLAYARLQCKNEFCVAHDYSSRPREVLFEITGQPHVSPQTDKFQCFFATAKPYPSRNTAMLNTFLELKVENERLQQRLLQLRAQQQVLDPQASPAASTSSAPPPNALPQDSYYGIPSGGSYDEVLPSPMASRVSFNTRGSFDTSGYAAPSSASGSGSVDDETTEAQRKKVKRMHAAEQYVCVTCGRTDSPEWRKGPLGPKTLCNACGLRWAKKARKEPDAEGDASGPSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHT8</accession>
    <name>A0A401GHT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612669.1">
        <property type="nucleotide sequence ID" value="XM_027756868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHT8"/>
    <dbReference type="STRING" id="139825.A0A401GHT8"/>
    <dbReference type="GeneID" id="38778673"/>
    <dbReference type="InParanoid" id="A0A401GHT8"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="253" mass="28575" checksum="6E8F41FB6C153270" modified="2019-05-08" version="1">MYCIDCATYNFVEPGSFCAICRRSQTLDTLIRLYPDYGDDTEQRASSSKRGRNADMGREVIDACAVVLKSGDYGADALAPALSKSENLVETLSLSSLSHEASDVGRLLRSLTTMLNEIRSKLQDVERLQQLQDERNSFKQAYKKQKEKLKDLTRIQGDLRMNAEVEIARQRNDLTARASNLQENLQAVISELSTQHARVEQQAHTIEDLEKEVLKWRSDATRYKKKYHVLKTNVNSGMKAAHDGFADDSLVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHY4</accession>
    <name>A0A401GHY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0401870</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612727.1">
        <property type="nucleotide sequence ID" value="XM_027756926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHY4"/>
    <dbReference type="FunCoup" id="A0A401GHY4">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHY4"/>
    <dbReference type="GeneID" id="38778731"/>
    <dbReference type="InParanoid" id="A0A401GHY4"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="14">
        <location>
            <begin position="25"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE81814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="767" mass="85867" checksum="0EA760D937020C58" modified="2019-05-08" version="1">MADVLTVSSAASPFPFAAVAIATYTQKVELAFDESASGVTLELDGSKITAEDQVVQALAKAGGLPEDGAKASAYFALAKTLPTLTAFPEIVAVLDSFDDHLAFRTYLVGQQITGSDWIVWGAFKGSVKIVGLLKNNKHPHLLRWFSHLESLESTQLAIASLAEAKSSKARLNKTAASFALGLANAKEGEVVTRFPPEPSGYLHIGHAKAAMLNQYFAQMYKGKMLIRFDDTNPTKERTEFEETILEDLALLEIHGDKLSHTSDYFDELYELALKIIKIGKAYADDTEQTQMREERYHGVASKHRDDSVEDNLKHFAEMKAGTEEGVRWCIRAKMSVDNPNKAMRDPVIYRCNLLPHHRTGSKWKVYPTYDFACPIVDSLEGVTHALRTNEYRDRNPQYYWMIEALGLRPVHIWDFSRLNLIYTLLSKRKLHWFVDQGLVRGWDDPRFPTVRGIRRRGLTVEALRQFMLAQGPSQAIVSLEWDSLWTLNKKVIDPIAPRFWAIAKSDIVPVTIKGGPADPEVKSLPKHKKNPGVGEKQTVFSSYVFVEQEDALSFDDQEEITLMDWGNAFVRSKTVNSAGIITAIEMELHLSGDFRKTKKKITWLAQPTPAHTLVDVTLLDYDYLITKKKLEENDDVQDFVTPITEFREDALADANVRKLRKSDIIQFERKGYYIFDGVAPDGRLEFIHIPDGRAASIASKANSQSATPITAPPLIKGKGAEAKSTSKALFDTPTDTKMYSVSTVYGEGEVVVPADTKMYKVKNVYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIA6</accession>
    <name>A0A401GIA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0402370</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612776.1">
        <property type="nucleotide sequence ID" value="XM_027756975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIA6"/>
    <dbReference type="FunCoup" id="A0A401GIA6">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIA6"/>
    <dbReference type="GeneID" id="38778780"/>
    <dbReference type="InParanoid" id="A0A401GIA6"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="83"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="408"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE81863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="556" mass="62766" checksum="78FE4513B0A141E1" modified="2019-05-08" version="1">MVQKTKVEGPSQAEQLLRVTSGIAAELIKAHDANQTVSLNELRAKMSKKYGFGGVPRLVDIISAIPDDYKKALLPKLKARPIRTASGIAVVAVMCKPHRCPHIAMTGNICVYCPGGPDSDFDYSTQSYTGYEPTSMRAIRARYDPYEQTRGRVEQLKSLGHNVDKVEFIIMGGTFMSMPEDYRNKFIAQLHNALSGFTGLDVDEAVRYSEQSRSKAIGITIETRPDYCLRPHLSQMLRYGCTRLEIGVQSVYEDVARDTNRGHTVRAVSESFHLAKDAGFKVVAHMMPDLPNVGVERDLEQFKEYFENPAFRSDGLKIYPTLVIRGTGLYELWRTGRYKNYTPNVLVDVVARILALVPPWTRVYRVQRDIPLPLVSSGCENSGNLRELALNRMKDFGAECRDVRYREVGIHEIHHKVRPESVELLRRDYAANGGWETFLSYEDPERDILIGLLRLRKCSDEGTFRPELVRKEGAEGGCSIVRELHVYGTAVPVHGRDPTKFQHQGFGTLLMEEAERIAREEHGSVKLAVISGVGTRDYYRRLGYELDGPYMSKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIB1</accession>
    <name>A0A401GIB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0402250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612764.1">
        <property type="nucleotide sequence ID" value="XM_027756963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIB1"/>
    <dbReference type="STRING" id="139825.A0A401GIB1"/>
    <dbReference type="GeneID" id="38778768"/>
    <dbReference type="InParanoid" id="A0A401GIB1"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="479"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="640" mass="71139" checksum="72F44781514333F8" modified="2019-05-08" version="1">MPASSRKSSIGSRRPPTKYVPYRGDDLQHGKKTGMAVAYVDHKSDEFEPFDKVISQADQRTPPRVHNARKRRTPKPKTPIVEEEDDENGEMSMDLEDSTAKSPSAYFANARVRTLTSSVQRVGSSLRPVAHGADVDFDKVPSPRGSPAVNGRKSLGRGRSSISGPSHLSQSTVAQDFEDIHVDNDGPSMDKGGGFGGFDDDDSDNEPAISPPPPQSHPKVNGHVSRRTSFAQIDQEDEDEDQEPGVYDSPSARARGKQRASVNPPRQDEDPEMEDEIAQGFAEIEQEPMDEDVQEVEEERPRKRGVQDKDDSLQKEQPASKKKRTENEGAKKPRGRPRKENVLREVIPDDNNADGLRRGTRTRYKPLDWWRCEKVVYGRRESGISLVPTIKEILRIPKEEPEPLGAKYRRRKKLRSKSKSQPVEEIDPASLVYNPEEGWDTATNPSGMVEDYETKTEITRRVAFTAKMLTPKPAANNDFFFQKIFGDGDFIAAGQLIIPPNKQKPTKSTRDNTFVFYVIEGAVNFKVHHTSYILTTGGVFLVPRGNMYYIENVAERDAKLFFAQARKVSKDEDEDDNSSSRARSLSQKLLLRSHRHSGGGSGSPVAHRSSSARGSSETLQAQPAHAAGAAALRRAASTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIL2</accession>
    <name>A0A401GIL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0403880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612925.1">
        <property type="nucleotide sequence ID" value="XM_027757124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIL2"/>
    <dbReference type="FunCoup" id="A0A401GIL2">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIL2"/>
    <dbReference type="GeneID" id="38778929"/>
    <dbReference type="InParanoid" id="A0A401GIL2"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="2"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="381"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE82012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="597" mass="66214" checksum="522F424FC47595BC" modified="2019-05-08" version="1">MCGIVIAHGLEKPSSDRPRIIACAKKIRHRGPDWSGCYSGKQTILAHERLAIVGVDTGAQPLVSTDGQIILAVNGEIYNHVKLRAELKNSYKFKTHSDCEVIIPLYKEHDKDLCPLLDGMFSFVLLDESVTPSRIIAARDPIGITTLYQGWSSKHPGATYFASELKALVDECDSIISFPPGHVYDSRDKSTCRYYQPSWWDGDLEGPGATIPEQPVDLTVLRGALEEAVRKRLMSEVPYGVLLSGGLDSSLIAAIASRETEKVAQAQAERRKRKLAEAQSGPPSPIGNGVSEYDTLASWPQLHSFSIGLENSPDLLAARKAAHYLGTVHHEYVFTVQEGLDAIPDVIYHLETYDVTTVRASTPMYLLSRKIKAMGVKMVLSGEGSDEIFGGYLYFHAAPDPVSFHQECIRRVKNLHTSDCLRANKSTMAWGLEARVPFLDKAFLEVALNVDPKEKMFSKGSAQEVDKDGRPKMEKYILRKAFDCAPDGKPYLPSSILWRQKEQFSDGVGYSWIDGIKDHATTIVSDEDFEKRAERWPENTPDTKEGYFIREIFDGLFPLEAAAKTAVRWIPRGDWGCSSDPSGRSVSIHNAAYGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIP9</accession>
    <name>A0A401GIP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">fructose-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0404590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the FBPase class 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612993.1">
        <property type="nucleotide sequence ID" value="XM_027757192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIP9"/>
    <dbReference type="FunCoup" id="A0A401GIP9">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIP9"/>
    <dbReference type="GeneID" id="38778997"/>
    <dbReference type="InParanoid" id="A0A401GIP9"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="14">
        <location>
            <begin position="140"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE82080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="240" mass="25844" checksum="8A49F6BE7548DB3D" modified="2019-05-08" version="1">MVNALRASGKTAVLVSEELDEAVLIDDRHKGKYCVVFDPLDGSSNIDAGVNIGTIFGIYHIAPGSTGTVQDVLRPGSDMVAAGYTMYGSSANLVLTTGHGVNGYTLDAALGEFILTHPDIKIPPRGRSIPSTKEIRCTSTHPARYIGSMVADVHRTLLYGGIFGYPDDKKSKSGKLRLLYEAFPMAFLIEQAGGLATTGRQRILDIVPKSIHERCPVFLGSKDDVQDVIKFFQEDGKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIQ8</accession>
    <name>A0A401GIQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0404370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612972.1">
        <property type="nucleotide sequence ID" value="XM_027757171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIQ8"/>
    <dbReference type="GeneID" id="38778976"/>
    <dbReference type="InParanoid" id="A0A401GIQ8"/>
    <dbReference type="OrthoDB" id="2563136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8775" checksum="FBB1C29FBABA9A32" modified="2019-05-08" version="1">MSSGKTAEDQTWKLKEQGEEARYVHQKEQEQLAAIRDQAAQAEMGAKGTAAAGRRDNDFEGGFGGQEDLEDRYATTSGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJB8</accession>
    <name>A0A401GJB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0406330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613162.1">
        <property type="nucleotide sequence ID" value="XM_027757361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJB8"/>
    <dbReference type="STRING" id="139825.A0A401GJB8"/>
    <dbReference type="GeneID" id="38779166"/>
    <dbReference type="InParanoid" id="A0A401GJB8"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33288" checksum="1E2FE6A5B0E72ED5" modified="2019-05-08" version="1">MAYRANYSGETRSPPQQYDDTPYNPYDNEPAHPTYDQAGYGYDSGTYGGYRDDPTPVASKERDRSVFEADEAVPRPRGPKNSRNLRNWRSESQGNLWTRGSGVWCFGRFFCCTIMIFLFLAISIIISLALWIRPPNVVVNEPTISSTNPVNLTSDGLTVNLDVNVSVSNPNYLSVNLKTVTADLFYPLSGNETAIGSGTAKNIDFRSDKQTNFTLPIALQYNMTNDPGFKILISLAGKCGIIPGQASSDITVDYKIILDMRVLLIPVKPTINSNFNFACPLSASEIGDLLKSAGLDLSGLGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK10</accession>
    <name>A0A401GK10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macrofage activating glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0408910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613420.1">
        <property type="nucleotide sequence ID" value="XM_027757619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK10"/>
    <dbReference type="STRING" id="139825.A0A401GK10"/>
    <dbReference type="GeneID" id="38779424"/>
    <dbReference type="InParanoid" id="A0A401GK10"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019414983" description="Macrofage activating glycoprotein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="37704" checksum="1D9B8518E1FF72FC" modified="2019-05-08" version="1">MSPVARSLLLTVALATSSVVAQYASSPLAFKSFTYTDLPEQAQPTAGIRGPQAGYNICNSTTQNQESMCQTAILNSIDDFCIWAPPQPNSTIADTEGIEVAYCTKNGRGTRLIPQGTLWGVSVLNTPQYVMILALLNQANVNMQASDYGGELDPHGADGNGNPIGGLVFSTHSFAGASDNTTLGQLTEWTSFIGGNQVCFKGCNPADVGGWNTGLCNNIYDEIGIAYNCPGTVTNGTFMVCDADPMSPVGIYTSNGVTMTYSQPASGVITSMPYTPTVPATSNCVTYKSTDLYTDLASVTASSQSTTSGGSATSTPTSHSGSSGSSSASRSGSSGAAAATGASGTNGASAMHVSLVATLAGVVAAVAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK92</accession>
    <name>A0A401GK92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0409480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613477.1">
        <property type="nucleotide sequence ID" value="XM_027757676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK92"/>
    <dbReference type="STRING" id="139825.A0A401GK92"/>
    <dbReference type="GeneID" id="38779481"/>
    <dbReference type="InParanoid" id="A0A401GK92"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="57"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="242"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="684" mass="75806" checksum="5DFC0BF4C6291A83" modified="2019-05-08" version="1">MSTLQFWKPGTVGPGSSLDRATEAEENVVPSAPFTSSLSIQGARERLPIFKHREKLLYCVEKYGAVIVVGQTGCGKTTQLPQYLHEVGWSTDGNIIACTQPRRVAATSVAGRVATEVGTLLGDEVGYTIRFEDVSDKERTRILYMTDGMLFRETLVDPLLSRYSVIMIDEAHERSVYTDLMLGILKKIRRKRPSLRLIVSSATLDATSFLDYFAAGNSPGEATIVSLEGRMYPVQVAYLQEPVSDYVRKAAEVVWNIHMQQGSGDILVFLTGREEIDHCLEELSEMLPSLPQNAMRLRLLALHAGLTTDEQMRVFEPSERGSRKVIVSTNIAEASVTIDGIKFVVDSGFVKIRTYNPTTSLSSLATVPISSASATQRAGRAGRTSSGICYRLYPKSALDSIPLTTQPEITRTDLTTPILQLKSLGIDDLMKFEWVTAPPAKSVLRALEGLVAAGMIGEDGRLTVTGEKVAECPVEVNIARMLFTSKDYNCGEEILTIAAMTAVQDVFVIPDGAAGALAELERRKFTAEEGDHLTLLNAYNAFTRYGRSSSWCKSHALSFRAMSRAVSIRSQLKKYMQRFGLPLESCEGDAKRLRKCLVSGYWRNGARWVADGTYRSVRGNTTLHVHPNSVLFTRKPRSGWVVFHEMEETKKTQIRILTEIESDWLLEYGHKYHDKRTGAAVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKI5</accession>
    <name>A0A401GKI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Modifier of transcription 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0410610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613589.1">
        <property type="nucleotide sequence ID" value="XM_027757788.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GKI5">
        <property type="interactions" value="836"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKI5"/>
    <dbReference type="GeneID" id="38779593"/>
    <dbReference type="InParanoid" id="A0A401GKI5"/>
    <dbReference type="OrthoDB" id="10252227at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1362"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1713"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1894"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE82676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1944" mass="214505" checksum="CA11F0751F47844C" modified="2019-05-08" version="1">MTSRLDRLLLLLDTGSSTSVRTTAAKQIAQLATKSVVGDAVLVEEDIKTNRQHVTLSDQSGWSELMAVVARILPYLHSRSHETRSAASTSLAQICALIPSWQPASGEEVMASDDMVPPSPPEFPPFSVQELMEKGTLLLASSGKEFTKPSGILSSSLEVKKARKEAMGRLGLDFLDSVGGADDMDIEKELAEDIDQDVEMSSVKAEEDIHPLSPTDEMVDVKMKESSPAGRSTSTTPAAPSPGPSATAAAPIDETAALSARERNRLKRKRKAGNGAFVAAPPPAQSVGARYSATAAGLSKARLVSTDDRAGPSSKAEHPQSPADGPSRDRVVIDPSKGGAVSPKVEKQSKALEVQSGCWPWDGVVKVLEVDLFSPAWEVRHGAALALRELLKIQGKCGGMRVDSSWGDNQIAHERWCNDLAVKFLCIFVLDRFGDFVSDQVVAPVRETVSQTLASLLIHMPRRSVLHVHSVLLQMIRQDFPITVKPSQGKLADRHAEKGHVWEVRHAGLLGIKYEVAVRSDLVSPDASRGHREVIESQKEVLRGVVDAAVLGLGDRDDDVRSVAASCLLPVAAHLVEQLPEELSRVLAVLWSCLGNMKDDLSSSVGAVMDLLGKLVTYNQVIEIIADQTRSHPISVLAPMLFPFFRHTIANVRLAVVKTLQAFMTVSSLPKDWIKLPFLKLLFQNLIVEERSDVRESTLSAWRLVLSILSPVDGWMHSLIQQQVLLDWYAVLMTPLGLPLDTSTFYDPTLAANHGVPPERHNVDKNMLAQDIALVTVEVVLKARIAAATALAYIMAFWPSAGSGMKLDDMFRPILAHYIDSTSMLQKFLAAIIAEQWAREYDNTASPSDPLLINKSTLAAEISGKTLAWLQGDAPPAYHEMAFTLARIHGECTNLLQSFVYDCKVPQSSIPSLGVEVDVTGTRPGCFTIDIAQAAVGEMFTTLKDILGRTKKRELAIIKEKRIKVMASIDRYIEVKAQYDVRVAAAFAAAFVAFKSTPDKVSPIVKGIMNSIKNEENVDLQTHSAIAVASFVEFCVQRDLPQPPDKIVKNLCTFLCQDVDQTPTFAYARKILSGVLSFPKSSAAHNNGKDISDKAALSPEEAEKARLSRRGARLAFEQLSTKFGPRLLEVVPKMWQSMAGGLLSACATDSVSKMDTMIEKHLGQDVIDSFSVLEAVVPTFHEALWPTLNELFPMVILALRSRFAIIRQSAARCFATICYTMTVEAMRYVIEIVVPFLGDSLNLAYRQGAVELIYHIVQQLDIKALPYVIFMVVPVLGRMSDSDEDIRATATNTFASLVKMVPLEAGLPSPPGFSEDMLQRRDEERKFLTQLLDGSKVEQYTIPVVIKAELRKYQQEGVNWLAFLAKYQLHGILCDDMGLGKTLQSICILASKQYERAKRHEEIHSPDSVHLPSIIVCPPTLTGHWYYEILKYAESLKPILYTGNSRERAKLLVKLKTYDVVITSYEVVRNDISNLQGLNWHYCILDEGHIIKNAKTKLTKAVKCIRAHHRLILSGTPIQNNVLELWSLFDFLMPGFLGTESSFNERFSKPILSNRDGKAKTGEAAALALEALHKQVLPFLLRRLKEDVLHDLPPKIIQDYYCELSDLQKYLYDDFSQSRARHAAEDVVRSEEGKSGQQQHVFQSLQYLRKLCNHPALVLKNDKQAILDALSNSGQKAESDDLSDIHHAPKLLALRQLLIDCGIGSAPGVGGEVAKSELIETESTGTGAFSQHRVLIFCQMKQMLDIIETDLFKHYMPSVTYMRLDGGTDAKKRHAIVQTFNSDPSIDCLLLTTHVGGLGLTLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLVTKGTLEEKIMGLQRFKLNIANSVVTHQNSGLASMDTDHVLDLFRRTTEEEDAAAATKHKKKDKDASSLPGQRNVLRGLEDLPPEEEYEGLDLSSFMGSLGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL87</accession>
    <name>A0A401GL87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0412960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613822.1">
        <property type="nucleotide sequence ID" value="XM_027758021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL87"/>
    <dbReference type="GeneID" id="38779826"/>
    <dbReference type="InParanoid" id="A0A401GL87"/>
    <dbReference type="OrthoDB" id="2603374at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="179" mass="19586" checksum="84E01F6776FEBDE2" modified="2019-05-08" version="1">MDTDTDDDNPPVHLSANSIYISLQLMLSPGSHWALLIVDAHGSTTRHHWAATIGADRAVAERYSHQCIDPVSTYTRGHNLNLSFCKIVGYSAPAPGFDFVGLFQTIFPESSSSIRANRNDGSNCRIWIIEALMLLQQNGLITRADTMEDVRRAIATLEAKAENALAELGGDFAPIMSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMJ0</accession>
    <name>A0A401GMJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0504960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614360.1">
        <property type="nucleotide sequence ID" value="XM_027758559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMJ0"/>
    <dbReference type="STRING" id="139825.A0A401GMJ0"/>
    <dbReference type="GeneID" id="38780364"/>
    <dbReference type="InParanoid" id="A0A401GMJ0"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29897" checksum="148C5E1BD3C86526" modified="2019-05-08" version="1">MDKPNPLTAESEPDVSLVFAQVKLLNYNEIPQAIETGVRACEEDSLFRYLIYDTQNADKRCRRQRYWLFYYLGIATAVHHREALTIDRGNSLVILRPAPNSRKDTLFDRTWKPVHTLVVRFLMAFDTKIQKERHAEFTRKLTITLKDTIADRIYDMMWLDGESTARDKQGLGYDFMLVGYAAGKADILGRAIWSCSYSTRRTELYEKFGFLTVGEFTVGEDNPTWDKPPVLIRVMVRQPQSFSRSNEKSQVGYTMFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GML8</accession>
    <name>A0A401GML8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0500370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613907.1">
        <property type="nucleotide sequence ID" value="XM_027758106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GML8"/>
    <dbReference type="STRING" id="139825.A0A401GML8"/>
    <dbReference type="GeneID" id="38779911"/>
    <dbReference type="InParanoid" id="A0A401GML8"/>
    <dbReference type="OrthoDB" id="3194625at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="52777" checksum="EDA944E5752BF37B" modified="2019-05-08" version="1">MVFTGGRRGGNSAKRRKVDDMSSSQPTAAVDVYFITGENLRRQDFQPFVTSTGSGGSDSSATAAQPAGPTSDSGSSGSSSQDSPTASASDSSSSAASDSSSASSDTTTPPPSSSPTSSSTSPSSTPPTQSSTPSSTPSATPSSTRSVTSSGTSSSASTSSNIPSPSSNSSSATPTSTPTSTPSSNSQTSSSSISTPPPTSSTSSNGTEVWVTSKIVISSNGVPISTVYTTFPSTLADSSSGMSTATRRGVIIGSVVGGVAFIGLIFAVVFFYRRHQHKKLNFFRREPRPRRSMLLEGEDMDDYDLGPRMQSYQDYPSSMDPRTQSYSHAPSPLPETVMVARNTPSPHLLGLRASDSGSIFQEAVWPPPKTLVDPLISESDDLHRIIDDVMGPSNASPFGAGASVRTAASASASTLPRTHARAMHSVSSDDSPSGHGRSTSQTALLPPDSPGSPTFPRSAPLFVTNMGSPTSTGSPPLPGRTTRWLERSPKKVSREVREEDEGEFVMGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMS4</accession>
    <name>A0A401GMS4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0505180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614382.1">
        <property type="nucleotide sequence ID" value="XM_027758581.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMS4"/>
    <dbReference type="GeneID" id="38780386"/>
    <dbReference type="InParanoid" id="A0A401GMS4"/>
    <dbReference type="OrthoDB" id="2507336at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNT8</accession>
    <name>A0A401GNT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0509450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027759000.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
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    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="151" mass="17106" checksum="A351DEED939DE459" modified="2019-05-08" version="1">MGRMHAPGKGISSSALPYRRTPPSWLKTTPEDVVEHITKLARKGLTPSQIGVTLRDSHGVPQVRFVTGNKILRILKSHGLAPQIPEDLWHLVKKAVAVRKHLETNRKDKDSKFRLILIESRIHRLARYYKTKQQIPPTFKYDSATASTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNV4</accession>
    <name>A0A401GNV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0508860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614742.1">
        <property type="nucleotide sequence ID" value="XM_027758941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNV4"/>
    <dbReference type="STRING" id="139825.A0A401GNV4"/>
    <dbReference type="GeneID" id="38780746"/>
    <dbReference type="InParanoid" id="A0A401GNV4"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="118"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="299" mass="34533" checksum="833882A43CF838BB" modified="2019-05-08" version="1">MPEIEYLLALPRSTVYHTLQHEPGSFNDTSTRSGRPRALTRDDVEFILEVCEIQPNIYLDELKEELELQNVDISLAALCRYLHRNGITHKRLARIARERDHARRALFVDTVQQYDAAQLVSVDEAAVDTRNMTRNFGWSYSGVRASERVPLERGIRYSVLPALSLDGVLHVNIVEGSFNAITFRHFIHTLLDRMNPFPAPNSVILLDNASIHHSEETLDMIVERGMRYIFLPPYSPDLQPIEELFHELKEWIRRNYIEGRAAMRCTNSPAHPWVFLMEGLDHITPDDAYGFFKDTGYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP23</accession>
    <name>A0A401GP23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0505550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614417.1">
        <property type="nucleotide sequence ID" value="XM_027758616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP23"/>
    <dbReference type="GeneID" id="38780421"/>
    <dbReference type="InParanoid" id="A0A401GP23"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="78" mass="8591" checksum="8CC7EA3A22CE4931" modified="2019-05-08" version="1">MSQHVPGSLPVRACLCILFHPISGRTVCHQKNMLLQCTALFLYPHIALLAAAKIFYLGLIMERSDVSTELSSLLSPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP89</accession>
    <name>A0A401GP89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aromatic-L-amino-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0506290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614487.1">
        <property type="nucleotide sequence ID" value="XM_027758686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP89"/>
    <dbReference type="STRING" id="139825.A0A401GP89"/>
    <dbReference type="GeneID" id="38780491"/>
    <dbReference type="InParanoid" id="A0A401GP89"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12229" checksum="BF5945B0511E348C" modified="2019-05-08" version="1">MDIEAFRKAGYAAIDRICDYYSTLQGRPVVPSVQPGFLTNALPTSPPEVGEDFEVIADDFQKLIIPGLTHWQHPSFFAFFPTAGTFESMLGDLLSSSVSNPGFNASSSTYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQA0</accession>
    <name>A0A401GQA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0603900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615324.1">
        <property type="nucleotide sequence ID" value="XM_027759523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQA0"/>
    <dbReference type="GeneID" id="38781328"/>
    <dbReference type="InParanoid" id="A0A401GQA0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="55" mass="6333" checksum="E7A072A34B3C8C58" modified="2019-05-08" version="1">MIPLILSETTLFYFTLARSSDGDDDDLLNKIKNWSKKIPYDWDELPGETAGVFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR34</accession>
    <name>A0A401GR34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0606540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615588.1">
        <property type="nucleotide sequence ID" value="XM_027759787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR34"/>
    <dbReference type="STRING" id="139825.A0A401GR34"/>
    <dbReference type="GeneID" id="38781592"/>
    <dbReference type="InParanoid" id="A0A401GR34"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="8">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001357-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="258" mass="27233" checksum="57A5393ACA5A20CF" modified="2019-05-08" version="1">MSLPAEPNTVSAVARLIDHSLLHPTMTDAEVQHGLDISRKYHVATACIKPYSIPQAMETLKGTGVGICVVIGFPHGNSTTTVKVFEATEAMDTLQTFVRAGGEAGGPGLAEIDMVVNVGKVLSGEWGYVEHEIAAIDAAVVARGGGVKVIFENDFLQHSHIAHLAEICARVGVKFVKTSTGFGFVKDAGGGYHYRGAQVEHIQTMRAGVGEKVQIKAAGGIRTLDQLLAAYRAGATRIGATATEAMLSEARARGWPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR56</accession>
    <name>A0A401GR56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0601820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615117.1">
        <property type="nucleotide sequence ID" value="XM_027759316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR56"/>
    <dbReference type="FunCoup" id="A0A401GR56">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GR56"/>
    <dbReference type="GeneID" id="38781121"/>
    <dbReference type="InParanoid" id="A0A401GR56"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="25"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="251"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="399" mass="45270" checksum="D07FE0995B1503E4" modified="2019-05-08" version="1">MDDDQRRQDDGADSRKNRLPSFTEVLSRRTRPPVDLFMFYLFLQREGSEDILDFWLDVQQHENLCRAYFKDVRKSGRTIREDWPEYWDYARRRGSIYGTVVGLNPHMGTKRSTTSTGDVISDQDRQNLAAAGDEKAVRSPSPRLTSAGTAVATEPPRSTTPFSLSGRTPTLFKRASRAPTIIPRSAAITRQNLIASAERIYFRYLSPVGTVGSNENHEIYLPPALRIHAFPLNSGHEPKSQSETSIMAQIPDMFHAQKEYCFRAMEQDAFPRFLRAKAFGNLTPVSALVRLIIGLVVLWVGLAVGFSLIFLDVKPKSKRFFLFLPFAVAILFLISHQYELDPILVFLGQSESTPFRTLRIREPYVKKLLLGRAIWVSVLVSACMVALTMIFWAVPGHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR87</accession>
    <name>A0A401GR87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0602120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615147.1">
        <property type="nucleotide sequence ID" value="XM_027759346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR87"/>
    <dbReference type="GeneID" id="38781151"/>
    <dbReference type="InParanoid" id="A0A401GR87"/>
    <dbReference type="OrthoDB" id="2756427at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21931">
        <property type="entry name" value="TD_EMAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049813">
        <property type="entry name" value="Elp-1-like_TD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="395" mass="43225" checksum="7BBC9C07A4E37EC0" modified="2019-05-08" version="1">MVHTDGTQRPGAAVAPEQVKVISYFSPGLQSELPETSYTITRIIQLFIEGMAIPAIERWDRAARLEGFKLSPKGSRDCEPYRARTLIPSPTRGSLYTFYGHPSGVLETLILDLQGGGASALPVAGGSVITERVEVQPEDEAADESSQYDDNAWYERAQASGVLELAETNGLLKVRVSELEKLCEQQQHEITSLKCEMKQMHTAQRQQATPSKFRAVHTLSGALSPLQHVADPSSPSPSAMSLTRPSVSLPSRPSRVRSATPSTPRQHHQTAITNPSTPPRLSVDSPLVRTYSLPPLMNAMSPSLSSPSSITHSSRSASHEYMATTEHRPIEAFGPATDAVMHSHDILAIMHNMLWHVERTSVTLAWQLDIEHHLQIAPDIAAELAHAMIEDLYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRF5</accession>
    <name>A0A401GRF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615709.1">
        <property type="nucleotide sequence ID" value="XM_027759908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRF5"/>
    <dbReference type="GeneID" id="38781713"/>
    <dbReference type="InParanoid" id="A0A401GRF5"/>
    <dbReference type="OrthoDB" id="2803789at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14855" checksum="193290A4332F6804" modified="2019-05-08" version="1">MLHTKGIYSLPLELRSHIVEYLINDHDSLRVLTFTCHAWRGVSQAHLFRRISVIARAWIHERRVSTLGGKLQNDWIYVILVLLPTRLTVLRTLTLTNVEDFAQYECTLPLGAFVEYVSLFKKFGQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSB9</accession>
    <name>A0A401GSB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0703010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616028.1">
        <property type="nucleotide sequence ID" value="XM_027760227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSB9"/>
    <dbReference type="GeneID" id="38782032"/>
    <dbReference type="InParanoid" id="A0A401GSB9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13506" checksum="6979C3D592CE18F0" modified="2019-05-08" version="1">MSNAPGHLTVVNQSKVMFAAIQSGQGVEAMLALLHTVDAKIDWLIAKVDKLNARVNDLDNNVDDLNSKVDNLDTKVDDLDSKMDDLDTKVDNLDTKVDNLEGRIDDLHTAIQPLTTHGSRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU16</accession>
    <name>A0A401GU16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0801950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616586.1">
        <property type="nucleotide sequence ID" value="XM_027760785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU16"/>
    <dbReference type="GeneID" id="38782590"/>
    <dbReference type="InParanoid" id="A0A401GU16"/>
    <dbReference type="OrthoDB" id="2968323at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="8057" checksum="A2773CF1B744B31D" modified="2019-05-08" version="1">MQEFEAYKRYEASIDALDLDLHSGGDGWVSIEDYPQVVDTWGKNKREWDKLERGGPFPYDDGMFSFFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUL9</accession>
    <name>A0A401GUL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0804020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616793.1">
        <property type="nucleotide sequence ID" value="XM_027760992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUL9"/>
    <dbReference type="STRING" id="139825.A0A401GUL9"/>
    <dbReference type="GeneID" id="38782797"/>
    <dbReference type="InParanoid" id="A0A401GUL9"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8912" checksum="E01A6B5763EBF217" modified="2019-05-08" version="1">MAFTNNFATSFRWCDRLFGTDIKYLEHRPRMNELKMSGLSREQFAATEKKMLEQVEAEGVVEAAKVEAYRYGSKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUZ3</accession>
    <name>A0A401GUZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glutathione transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0800710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616467.1">
        <property type="nucleotide sequence ID" value="XM_027760666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUZ3"/>
    <dbReference type="FunCoup" id="A0A401GUZ3">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="GeneID" id="38782471"/>
    <dbReference type="InParanoid" id="A0A401GUZ3"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="764" mass="86651" checksum="231149F2170C74BD" modified="2019-05-08" version="1">MSFYVREEKLSSGSSSNEKFDVERQIVTVPVAEFDDPNIDKDAIILEDDSPYPEVRSAVANTDDPDMPVGTFRAWCIGIVWSVIIPGMNQFFFFRYPSVTVTGIVAQLLSFPLCVLWARIVPRVKIFGVSINPGPFCVKEHVLITIMATVGYSSAYATDIIAVQRVYYNQIYNFGYQWMVVMSTQLIGFSIGGICRRFLVAPPSMIWPTNLVTCALFNTLHSQQYAGIGTRGGLSRERFFTYAFIGAVCWYFLPGYIFQALSYFSWVCWIVPDNIVVNQLFGYESGLGMSLITFDWSQIAYIGSPLATPWWAEANVAVGFVFFFWILTPIFYYTNTWYAKYLPISSRTSFDNTGASYNVTRIINPDSTLNEEMYKAYSPLFLSATFAMSYGLSFASITSTIVHTLLYFRKQIWVQSRRSLSEQPDIHARLMSRYTPVPEWWYSVILVTMFIFGVVSIEVWKTQFPVWALVLALIISFVYTIPIGMIQAITNQQIGLNVITELIIGYALPGRPIAMMMFKTWGYITMYQALQFTSDMKLGHYMKIPPREMFWAQIIASVIAGTVQLGVQAWMFTNITDMCSPNQKDGFICPSTEVFGTASIIWGVIGPARQFSKGQIYYGLLFFFLVGAVCPLISYVLSRKWPNSFFKYVNFPVIFNGTAYIPPASALNYAPWAIVGFIFNYVIRRRHFSWWTKYNYILSAAMDSGLAVSVIIIFFCLQYPADGTIGLNTIQKWWGNTVFLNTADGKALPYLTVSGNATFGPKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVC8</accession>
    <name>A0A401GVC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metacaspase-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0900330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617069.1">
        <property type="nucleotide sequence ID" value="XM_027761268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVC8"/>
    <dbReference type="FunCoup" id="A0A401GVC8">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="GeneID" id="38783073"/>
    <dbReference type="InParanoid" id="A0A401GVC8"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="4">
        <location>
            <begin position="68"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="40198" checksum="7D09CF9B3930DAC4" modified="2019-05-08" version="1">MWEEEPHQHHQHHHHHHHEDVYIVSDDSSYVLLRPPAERRHFGPLFQDEDENGDDRRLHFQYSQCTGRRKALCIGINYIGQSEELKGCINDAHNVRRFLCEDYGYQYEDIVVLTDDSSNPRSIPTKENMIEAMKWLVSNAQPHDALFFYYSGHGEQTKDMNGDEQDGYNDVIYPVDFQENGPLVDNMLHDILVKPLPPGCRLTTIFDSCHSGTALDLPYIYNHYGKIKEPGFIKKASQGLLTAFAGCGFARAFSSAIEFMERRLRQTKTSPADVISWSGCKDSQTSADMFEADQATGAMSYAFMTSLRQNRHQSYQQLLVNLRGMLPQHYNQTPQLSSSHPMDTRLLFIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVJ7</accession>
    <name>A0A401GVJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0803060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616697.1">
        <property type="nucleotide sequence ID" value="XM_027760896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVJ7"/>
    <dbReference type="FunCoup" id="A0A401GVJ7">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVJ7"/>
    <dbReference type="GeneID" id="38782701"/>
    <dbReference type="InParanoid" id="A0A401GVJ7"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051068">
        <property type="entry name" value="MFS_Domain-Containing_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23510:SF64">
        <property type="entry name" value="INNER MEMBRANE TRANSPORT PROTEIN YAJR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="54508" checksum="36473BBEA6EFCDB4" modified="2019-05-08" version="1">MSPVRLPSTVLDICRSLRHRRALSSRHPARGDHQVAQDHELKLPKIGSLVIVLSASALLQVSFFIIVSSSNEYAQHLGGTSTFSGLVIGIPTVFSGLALLPLMKVDQGRYKRPLHFACGSAMIGSILYSLAYKANFLYLILIGRIVSGFGFTFWMYSKRYCSDPRIVGIRRRTTLAGWLVLGQGAGFSIGPFIGGLLYRVGFSNSVFNGYTSPTWIMAIIWAVFWAVAAVVYEDVPITPSAPSAIELAPVLTNLQPGVGVSGSADLQQDTGPSVKQEEEITVVFAPTTELETIPLQTEEPRVRMSLPQWGVTATMCWFAMTCFFILGAWEANIPVFTAMHSALSPFQFSPYAAGNLIALGGICTIPFLLLNVFFARRVQDRHTLAIGTSLGLVGLIITIAIFSTRKVNYGSLFVCWFLIALGFNLASTVTLSLLSKQLPGDWNAKISLAIQYSNYTGRVTGAVWGGSGVTVGMLNYVGLQIAVVGIGAVMFLTLWKNLKAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVK0</accession>
    <name>A0A401GVK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617125.1">
        <property type="nucleotide sequence ID" value="XM_027761324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVK0"/>
    <dbReference type="GeneID" id="38783129"/>
    <dbReference type="InParanoid" id="A0A401GVK0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="152" mass="17014" checksum="2405B8E76016A48B" modified="2019-05-08" version="1">MVPYVFYFNHIRVQPFFLLQYPPPSSMNVSSMNIKIGVFYINYARTSRTYFTLDVDSTYDLPSPQITIKVLRQSINAYNKSTATKESGDFSKMTTNEPLSPDTRTLKACGIADGQSVIAIQTNTINPIFRIMPVDSPGDGSPDIFLSSLPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVX8</accession>
    <name>A0A401GVX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0902220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617256.1">
        <property type="nucleotide sequence ID" value="XM_027761455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVX8"/>
    <dbReference type="STRING" id="139825.A0A401GVX8"/>
    <dbReference type="GeneID" id="38783260"/>
    <dbReference type="InParanoid" id="A0A401GVX8"/>
    <dbReference type="OrthoDB" id="2507743at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44310" checksum="22494239CEE4F97F" modified="2019-05-08" version="1">MVFPFNFKLSAPGPANPFASPQMRRPSNSAPGDRDFDKRKLGNFLHPRRPPSPSLLPPLAKKRGWIPSIPEPSPAAAFPTSTSGYLDTPAKYRDTVEAAIQGDDIDEMVADLPPPKRRRTLTGSIVSTAMSAALIGTAVGLTVYRLWKDRSKHPEQLPPPPYEQGEWVPPKHELSTPISPITPTADAESPAPRSKKNHHVAGRRTAPRHRKTVSRANIIGNSPPMGSSVPTARMPIPAQFNFVGADEPEVDVDDQMSWMGDRLAQLIAEGQRALGKEVVVMSEDQEEPVDDGADGWVEEEDDDTPSRRSRFSTGKGKQPWGPALPSYSPSHGFPRHDRTTFDMKPSAIAVPSLGSPRLGREASLESEGFTSASFMEDESVWQTEELRESMERARMRYQRNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW00</accession>
    <name>A0A401GW00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0902870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617321.1">
        <property type="nucleotide sequence ID" value="XM_027761520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW00"/>
    <dbReference type="GeneID" id="38783325"/>
    <dbReference type="InParanoid" id="A0A401GW00"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="84" mass="9700" checksum="1F465C970F64B90C" modified="2019-05-08" version="1">MWKRQTRRRRVLYHLINANPTVNQTKAAARLMEHLELTGLDWAQAETGRNPNLGVPDNGLGGTLIGWRGMQSALIWLFLRSFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW48</accession>
    <name>A0A401GW48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0902990</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617333.1">
        <property type="nucleotide sequence ID" value="XM_027761532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW48"/>
    <dbReference type="FunCoup" id="A0A401GW48">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW48"/>
    <dbReference type="GeneID" id="38783337"/>
    <dbReference type="InParanoid" id="A0A401GW48"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="21"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE86420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="362" mass="39186" checksum="2878827F0FB91E31" modified="2019-05-08" version="1">MSSARLANRAIVYTENGDPSKVLTTLTYPRLAPPPPGALNVKFRLSPINPADLNVIEGVYPSKPTPTTALNGESLLVGGNEGLAEVVEVGEGVSGLRKGDWVTMAKPQAGTWASALTVEVRDVIKLPSGGISEVNAATITVNPPTAYCMLRDFVDLQEGDWVVQNGANSAVGQAVIQIAAKRGLKTINFVRDRPNRDALKNQLHALGATHVFTYEELADKATSAAIKEYTGSKPIRLMLNCVGGKPTAQMTRLLGSDAHLVSYGAMSKQPLSLPTSTFIWKNLAAHGFWMTRWYQGHSAAEREELMRTLVGLQLKEPEHEILTLRREKSDAEVTETVRDAIARIGQGMLGKKLLLQIEEPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWF7</accession>
    <name>A0A401GWF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0904360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617470.1">
        <property type="nucleotide sequence ID" value="XM_027761669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWF7"/>
    <dbReference type="STRING" id="139825.A0A401GWF7"/>
    <dbReference type="GeneID" id="38783474"/>
    <dbReference type="InParanoid" id="A0A401GWF7"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="168"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="697" mass="76805" checksum="E7F9C6BC9BDD5B03" modified="2019-05-08" version="1">MDTMEMVMERMSRKRSRASSNAPSRDARRVPAPVSSAPSRSATPQPIPATPHHYRYYSERVVGEASLTPLSPVTPRQGRRTLRDPSQLVPRDHLDFRVPEQHINYPKTPAGRHIYSSSARRTPSLSSSPARIVNLVSSPGPMRPIPLAQDDKDDLPYVLPPGPYQTEKPDFSYAAMIGQAILSSPQHRLTLQDIYEWIATVYSHYKRGEQTWMNSVRHALSTMAVFRKVPRVRTEGKSLWAIWDDDLECFANGGFRKAFCVDMQNDRSKQSSKKRAMEDAVPKKTKKRKKLEDVDVSTTGPPPPMLPASVLAPFFPSFHPNPHHQPYYQTYTSQPLPAEVIFPPLPASSNYHQVIARSNASRSESIESIAVGRNVQEETEEPEPPRRGRDPSPKFISSSSPVPDLTPNCSSSSSPLPSSITSLSRESQSPARRKQVGLTNHGEEPEDTDSDWLGVCPSVDSLEPGFTLLSHYLGPSKKPGRDKRPQAFSLPLRQVSPTPTRRVKSGKQAKHGRVAITPPPAGPSVGPSTPPRKRVASGSGIQLSPIRTPISHMGLHMSPSPSLAHYKLHLDPPPIAVYHPQAPLLSVSSDRELSPSVAVHSGNVHTPSRKRSSATDFLLPVTPKRLVFSTPTSESPFRTPSRSILDPHDPSTLLDEELCRLGSQVSPGYSTLFGRSSGLLYESPGSGRSPASWGNFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWR5</accession>
    <name>A0A401GWR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell cycle checkpoint control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0905470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617580.1">
        <property type="nucleotide sequence ID" value="XM_027761779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWR5"/>
    <dbReference type="FunCoup" id="A0A401GWR5">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWR5"/>
    <dbReference type="GeneID" id="38783584"/>
    <dbReference type="InParanoid" id="A0A401GWR5"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="495" mass="54039" checksum="5EE78F79A4B4DF76" modified="2019-05-08" version="1">MQATLDATALKHLTRALICLSKYGDDLTIYATPQTLALSATNSSMSAYCRFKYDKQFFSKYNVGNTAAAGSSRTEVEEVPTATGQLLTKSLLSILKHRTVEKTVEKCELAILDGVQDGRNDENEDTLESRLIVRLHCKHGVIKTHRLLLLAQTCLMAPGMLDTPCQSRLTIGPRALKDMIEHFPSAKGSKSDPQLIWNFADSEVSVRSLETSIDTKGRAQLATELIISADEFNVYDIYTLPTTIAFHLREFNATIAFAESSAHPLDIRFTDPAAPLYIDVEGDLSETLFVISTSQIHGVPSSIAGQARQRNITSVGPQTRGKKRQLEDDSNASRANSGMSAGQERVSWPMKVVQATDRASLARELSDNNARGTSRSLAGSMPPPSLPLATPSQNAPPTPRPREPLFFPSSQLSQAAQDAIRESGLGIENMTAEEFEAMLEGDGEEVGLDPDEELGNLFHDVPSDAGQDSLDIYDVEMEPTQSDEGTKAFKPLFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXM9</accession>
    <name>A0A401GXM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1002230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617891.1">
        <property type="nucleotide sequence ID" value="XM_027762090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXM9"/>
    <dbReference type="STRING" id="139825.A0A401GXM9"/>
    <dbReference type="GeneID" id="38783895"/>
    <dbReference type="InParanoid" id="A0A401GXM9"/>
    <dbReference type="OrthoDB" id="3210574at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="913"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116772" checksum="E47D0F893FADF8A2" modified="2019-05-08" version="1">MFGTPVPPAENGNTLIEENPVDPLSLDAAEEVASSINDHSPSPPPVFDPPCEPDTCLPVDAVEELRSHPLPTTDDPRSSKRARVDDVEDENDARGLPRRPWTEDYPGDVGTVSSVGETMFESIQRCKVRSGEHDWAPFDCEEEWELARWLMTSGLSQMAIDDYLDLNITHACSRLSFKNKYAFIKKIDMLPHGTKWECELFEAVGDELDDDNQPRKEVLKLWKRDPVECIRELIGNPVFKDVLHYAPERLYADEAGQNWLYGNMWTGNWWWDLQKQLPAGATIAPVILASDKTSPSRFSRDKSAWPIYLSLGNIEKSTCHKPSQHATVLIGYIPVSKLKCFLKTRQSIEGIRLFHECMRSLLQPLIHASQEGVKMILRGIPSGFGTLTHTLTPGEEYVPLEGKGRGTAQSTQGYTPALHYLHQLHKGVFKDHLVAWAMKSAHDNGDAKELDWRFQAMMKHSDLCYFKDGISLITQWTGTEYKNMEKVFLGVLAGATDPEVTCAVRSVLDFIYYAHFEMHSEDSLAKLEAAWRNFHWYKFHSAEHYPLSIRSLGTADGYSMEGPECLHIDFAKVAYGASNHKANYLTQMTVWLEHQEAIHRFDSYLSWVVKKQMVESQHEETEEEQDAEGENSVESETRSCQNQPVKEDRFAKGYTIAKEPAYPRMTVAAVVQDFHATDFIKCLEDFLRRIDISESRGFNQSHIGRRADVLTIHDKTRVPVYTQMKVRLPAVQQVTADEVIDTIYASPARAAKGVQSELPTHQSTVLVKDPSAPPVAEGDHLLHGLRVGQVCTLFKLPDVLVSEHPTLASVPLAISSLLTLCDGGTEPASDLAKAPRMCPTSCLLGGWHRCTTTATERYILTSEHRNDYPVTRIHLTLLTTISRILQHTVSSRSLKNASPPAHHVHRDSEFLPRANGALPSAGYSTDRTNDSRTRAGSNERRYGVDTNHGAVVRDEQQHGSVTSGALSTESGHNAYTEGKPLGMQPTSQGGQDDFLQGKASSTDKFIEKTRKVAGKATHNAELHEKGELRQSGGKAAVTGEASAPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXX2</accession>
    <name>A0A401GXX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1003040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617970.1">
        <property type="nucleotide sequence ID" value="XM_027762169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXX2"/>
    <dbReference type="FunCoup" id="A0A401GXX2">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXX2"/>
    <dbReference type="GeneID" id="38783974"/>
    <dbReference type="InParanoid" id="A0A401GXX2"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="518" mass="55614" checksum="8D6A591CC8D85525" modified="2019-05-08" version="1">MTSEEMEKTNSKGEDLAASVDVHDATDDLFESGAIDPVYQAKARVLNRAIQEIGMGKYQWCLFAVAGFGWFADSVWPLIGGLILSPVVNEFHFNGPFLSLALNVGLFVGAVFWGLGCDIWGRRWSFNLTLLIAGIFGLAAGGSPNFVTLASLLAVVGVGVGGNMPVDSAVFLDFVPGSHQFLLTILSIWWSIGQLVASLIAWPLIANFSCPEGSTSCSRSENMGWRYLLYTLGGITLVLWAARFFLFHLEESPRFLVGLGRDEEAVAVVHRIARFNGRVSSLMVEQVELAGEKAGAGERAAGGRKLLSQSSMFSMGHIKALFVTRRLAWSTSLLIALWGIIGLASTLYNSFLPYLLASRGARFGDSTYYTTYRNEVILGAIGVPCAFLAGWSVEQRYIGRRGTLAISAGLTSVFLFASTTARNSDALLGWNCGYAFFSNIMYGVLYAISPEVFPAKDRGTGNGLTATATRTFGIIAPVIALYANLSTAVSVYVSGALIIGSGALALLLPYEPRGKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYF0</accession>
    <name>A0A401GYF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1004360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618102.1">
        <property type="nucleotide sequence ID" value="XM_027762301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYF0"/>
    <dbReference type="FunCoup" id="A0A401GYF0">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYF0"/>
    <dbReference type="GeneID" id="38784106"/>
    <dbReference type="InParanoid" id="A0A401GYF0"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="273"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="632" mass="69831" checksum="2EE93E93BB96B455" modified="2019-05-08" version="1">MKRSPGSPIISPDPLQMTSPPALKKFKAAPFSVEDGDNEDGAWTKVERRKAKKVRKTEVKLDALPIPRFMYASGEILKRREAVGISDIRELVLHLVADAPPPSWVRVDNPRTIQKVVALLIPGLTPEIVALPPLPTSATANPNLPLIVPLPPDSPAERLAHGVPFISSTFSHACPTRAPGDQTRMHSVLNAFFQGPITGDERKRRAMQRITSERNQDSTPLRYLLTTEQMIENEYPVPSYIAEVFEKPLEWVEIPAPRKEPFPPTIPEKSLPRIYAIDCEMCLTEDGKELTRVCMIDYASGKVIFDQLVKPKKPIQDYLTRWSGITAEALDPVTTTFEEVQSHIISLLSASPTPVLVGHSLESDLKALKICHPHCIDTAVIYHHPRGRPLKPGLAWLTKKWCGREIQNRGEGGHDPEEDARACLDLLKKKVQNGAGFGEFKTDLESIFERMARSRSGSICTAVVDHGNPTAWHGSKATTTVACKSDMEVFEGLLGAVHSHHFLFARFTAVADGLGWITNKANSDVLPSSPALSSTSPSDMRAILSSLDEQLSRLYAALPPRTALVIFTGHSDPRRMSELNARKAAFESVLRQGRSVEDIGQDDRWTSADGRALEEEVEKAKRGLLFLGIKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYM7</accession>
    <name>A0A401GYM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1005120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618178.1">
        <property type="nucleotide sequence ID" value="XM_027762377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYM7"/>
    <dbReference type="GeneID" id="38784182"/>
    <dbReference type="InParanoid" id="A0A401GYM7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019082324" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="14096" checksum="1D622D14D9F3BE13" modified="2019-05-08" version="1">MKHPPVLLALVLALGVHAQSASSVSHVSMRTPTFPLSGIPLSSVFPSATSVPSSPPESSAAPTSEPSASSEPATSASSSASSAPGASSASSVTSAPGSSVTSAPSASVIRSSSAPSSTSTSGARPLAHAMQLPLPVGIALGALLLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ77</accession>
    <name>A0A401GZ77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618377.1">
        <property type="nucleotide sequence ID" value="XM_027762576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ77"/>
    <dbReference type="GeneID" id="38784381"/>
    <dbReference type="InParanoid" id="A0A401GZ77"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7225" checksum="0E0EE62FF78CB8F0" modified="2019-05-08" version="1">MNHVLVILEAEACRHPCAIPHVGTSDCVADRNRNFAATPPFKVASISPSAPQDIQHSGDCVEDMGPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ95</accession>
    <name>A0A401GZ95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1101730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618409.1">
        <property type="nucleotide sequence ID" value="XM_027762608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ95"/>
    <dbReference type="STRING" id="139825.A0A401GZ95"/>
    <dbReference type="GeneID" id="38784413"/>
    <dbReference type="InParanoid" id="A0A401GZ95"/>
    <dbReference type="OrthoDB" id="2999773at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="153" mass="17061" checksum="BC14E3B4BA05590A" modified="2019-05-08" version="1">MTRDVYLISYDSPLFPAHWSLWVPLATEPTLGKRIHVAGDVFTGFVHEFARQYSIASTARKHTLVFLAQVQDIHVGDVIDREGCDNEPVDDIERAALSVPAPGKSLNVAGAERRNKVHILNCQTWMFQFIEALIAADILPESALEVPKKAPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZM5</accession>
    <name>A0A401GZM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1103020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618538.1">
        <property type="nucleotide sequence ID" value="XM_027762737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZM5"/>
    <dbReference type="GeneID" id="38784542"/>
    <dbReference type="InParanoid" id="A0A401GZM5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="158" mass="17175" checksum="47FBD525343EFB5C" modified="2019-05-08" version="1">MQDPRESPAIATSCSSARSSPSTTRRRMSRRSGSPSPRRVRSGSRAKQAEIPPSALGSGLDGWSIYIDLNSDRVNLRQHRGTTLSAAPHLGPQARHAPVPALDPRLLDIVRVGTIHEVLLHQARGGPDHDPPAHIGTRRCASCHTPCAPHRMLLQMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H067</accession>
    <name>A0A401H067_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1200160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618705.1">
        <property type="nucleotide sequence ID" value="XM_027762904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H067"/>
    <dbReference type="STRING" id="139825.A0A401H067"/>
    <dbReference type="GeneID" id="38784709"/>
    <dbReference type="InParanoid" id="A0A401H067"/>
    <dbReference type="OrthoDB" id="47488at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04486">
        <property type="entry name" value="YhcR_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="284"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="618" mass="66895" checksum="EBB918B78D6D08AF" modified="2019-05-08" version="1">MSHKSLCGSSRSELRNVTGVVTAKDKYGVWILSEASDDVRVSNGLRVYGWSISKLVNIGDMISLSGKVSEYRANASPNDLFLTELASPQDVTVISRDNVAIPIVIGKDRIPPTGSLTALDKGADGWLSVPNNVTLLEPVNATLQPDLYGLDFWESLEGQLVAVQSPVAASFPDRFGSIWVYGDWPVTGKNTRGGLTITFSETTGIPHAHPETILIGRPFDGARNPSTSIGATLTDITGIVTYQYGYYYILPLTAPKIISVPEIEVPTSSLTSTKNPCEITIGDYNVDNMSRRSRHLTHVAEHVADYLHSPDVLFVQEIQDDSGSSDDGTVSAAKTLTTLVSAIKKASGGVHYAAVDIDPENNMDGGKPGGNIRVAYLWRPDKVSPVPGSPIGKATEATEVLVDEKGKLSLTLNPGRVNPTNSAWEETRKPLAAAWQTTSGERFITVNVHFSSKRDSSSAQGDARPPVNGVVERRSRQVDVIANFVESILIQDVNASIIIGGDMNEYIQTRTVFAPFVGLLTDINDAAGVPQEERYTYVYDQNMQEIDHVFLSAAVARRAPLVEHVHVNTWAASLSARASDHDPSVAKVWVCEPDNEDASSDSSIVLEYTDYVEGQLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H076</accession>
    <name>A0A401H076_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">XLF-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1200270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618715.1">
        <property type="nucleotide sequence ID" value="XM_027762914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H076"/>
    <dbReference type="GeneID" id="38784719"/>
    <dbReference type="InParanoid" id="A0A401H076"/>
    <dbReference type="OrthoDB" id="3184250at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="406" mass="44965" checksum="731A185D09696DC6" modified="2019-05-08" version="1">MEYLSEDHYKLLLNKEWLVRIDSEKSIPYLLKFYSSTVDQCCCIMITDTKGVWGEVLSSKQFARRWRDCNPQSSSMFITTEEEDEWRTSTLELVSSAHTLGGILDLSFDIVDSRYADFAFELGSDAFKWRWETYNVGPKVSADLISKHLIMPLISVTHLAFSSADTISELSEVNLEKAVDKVGRTARRTVDTHVKNAISRPRVATTLRRMTAIFNFLPELPSISSSVERPNLLSPPQRSRAPSKPPQDRLLGSPVVPAHGTRPSARFPPGSQSPSSQNLPPKQAADDDSATEQSDDDVPPPQKEKGKAKDLKVQNHILPSALASRSGSPTRVSSKSQPTPDKSGSQEQAPGDGSSPEPVSKRVKRAPVVSSSDEDSEAERRRRVVQIKGGVQRGAKQPLKRGGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0M2</accession>
    <name>A0A401H0M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1201660</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618853.1">
        <property type="nucleotide sequence ID" value="XM_027763052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0M2"/>
    <dbReference type="FunCoup" id="A0A401H0M2">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0M2"/>
    <dbReference type="GeneID" id="38784857"/>
    <dbReference type="InParanoid" id="A0A401H0M2"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019013892" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="16"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE87940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="534" mass="59801" checksum="770A4A596EBF9338" modified="2019-05-08" version="1">MSAVLDLLIVATSWAHVFLAPYTKVEESFSLHATHDVLMYGVRPDVLPKVLLFSALLKEPQTHAPTWLSNAPIRLACSLELVRDKFDLQIIVRLVLATINAIGFCLLRRTVSRRFGGLTSVLFAFLTCTQFHLPFWMGRTLPNMFAVFPVNVALSYFVNRAPNSTRPSRYSIHWAIALLTFTAVVFRSEVVLLLGPLVLQAVVRRYTTLTNIIKIGLIAGLSSVALTSAVDSYFWQQWPLWPELYGVYFNVVQGKSSEWGVLPFHTYFTSFLPKLLLSALPLSFVGALSDSRVRALLVPAVAYLVLISGLGHKEWRFIVYIVPLFNIAAARGGAWLMSRRKSSLFGRLCFLAVSGLLVCNCVTTYLLAMASIANYPGGEVLSKFNELYASHENVHVHISNLAAQTGASLFLQTHMPPYLHCLPHSQQHWTYNKTEHLSPEAFTFTPAVTHVIAEFDGSTASKHYPAGFSANKWHATGTVDSFDRWKFNPDLKDSLKMRDVGALLRPLEMVRSKKLVILERNIWTDAVQATDKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Q4</accession>
    <name>A0A401H1Q4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1301760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619274.1">
        <property type="nucleotide sequence ID" value="XM_027763473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1Q4"/>
    <dbReference type="STRING" id="139825.A0A401H1Q4"/>
    <dbReference type="GeneID" id="38785278"/>
    <dbReference type="InParanoid" id="A0A401H1Q4"/>
    <dbReference type="OrthoDB" id="3243310at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="11155" checksum="35AE8A1C70684D3A" modified="2019-05-08" version="1">MQSFQSLDREMDTTLILLASPAHSSKLCDPALLNSSKLTAIRTSKFNHLASQRRIAHSQWISLFDQLHLSSPSIRGSPGSHLVTIPTDDWIFFYGWVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1R4</accession>
    <name>A0A401H1R4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 13 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1301860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619284.1">
        <property type="nucleotide sequence ID" value="XM_027763483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1R4"/>
    <dbReference type="STRING" id="139825.A0A401H1R4"/>
    <dbReference type="GeneID" id="38785288"/>
    <dbReference type="InParanoid" id="A0A401H1R4"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="37"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="532" mass="61204" checksum="740DA38FDAD7D541" modified="2019-05-08" version="1">MDIFRWLIEWFDQYVRPYPPPALENMRLGPDGLTENALMIQFFTWQSRHPTMSWWKHFESEIPGLADIGVTQVWLPPPHKAMHKHGQGYDAYDLWDLGEFYQKGTVPTRWGTKDELVQAVATANAHKIDVLIDAVLNHKLGGDRCETFNAVPVDPQNRLKELTPAREIEGWTAFDFTGRGGKYSKLKWTHEHFTGLDWDHRRRLKGVYRIVSNKHKGWSQNVDNELGNYDYLLGMDIDHRHPEVRKDLFDWGNWVLKTTGASGFRLDAIKHMDRCFLLDFLKHVRHCTGRPNLFAVAEYWSGDVNLIKPYIRAFEGVVTFFDVPLHYNFHEASKTGARYDLGTIFDNTVVKLRPGDAITFVDNHEYQVGQSLESWVGSSFKLQAYALILLWGEGHPCIFYGDLYPNEECYDEVVAQGLRRLIEARKKFAYGTKMDYFHDRNCVGFVRMGDSMHRGCAVLVSNSHHSHGAHTIRMNVGTGNGGSSFGSFMDRSRRVQISPDGWGLFTCIPGHVEVWVRDDHLTFDSDSPDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H300</accession>
    <name>A0A401H300_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arginyl-tRNA synthetase catalytic core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1401890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619697.1">
        <property type="nucleotide sequence ID" value="XM_027763896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H300"/>
    <dbReference type="STRING" id="139825.A0A401H300"/>
    <dbReference type="GeneID" id="38785701"/>
    <dbReference type="InParanoid" id="A0A401H300"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl-tRNA synthetase catalytic core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="108" mass="12558" checksum="DE8BDE2CBD73455E" modified="2019-05-08" version="1">MRTRIQRAAAFFKRMEDGDEDALKDWRVLHVHFDVYTVESRVSEESMDNALPQLDEMGLIEDEEGAKRVNLEKCKLVKAVVRKKGGTSIYLTRDIGGAIERYEKYEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H309</accession>
    <name>A0A401H309_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1402230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619730.1">
        <property type="nucleotide sequence ID" value="XM_027763929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H309"/>
    <dbReference type="STRING" id="139825.A0A401H309"/>
    <dbReference type="GeneID" id="38785734"/>
    <dbReference type="InParanoid" id="A0A401H309"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="6">
        <location>
            <begin position="328"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="537" mass="64066" checksum="9975BD545B9776AC" modified="2019-05-08" version="1">MGNAQSAEQEGHERWQAEERAREEQRRREQEAHERWQAEERAREEQRRREQEAHERWQAEERTREEQRWREQEAHERWQAEERAREEQHRREQAEHERWQAEEARRRAEEARQQAEHERWRMEEEQRRIENERREAEESRRRAEEELRRVEEERQRAEEERRRAEHAKWEAEEQRRRADEERQRAEAEQWRAEEERRRSDEEKQRAQQEKERAEEASRVAEAQRRQADEERRRAEEAQRRAEEERRRAEEDSKRAEEERRKAEEAKEKARTAQEDAERASAAAESAAEEAQLAQQEAEKNLKAGIRPVIWPTEEEIRIHKERLQYHEGRLHFAVAGIAGSGKSSLINALRGISNSHKDAAPVGVTETTKVISRYQDSNPERLFVWYDVPGAGTLAIPGWQYFNDYGLYIFDAIIVLFDNRFTETDIALLRNAALFHIPTYIVRSKSTQHIANLMMDLDFGEDEDEGRCRATARQTYITETRDSVAHNLCEAELPGQRAYLITAKEILCEVVKGGMPKDIIDEAELLSDMLQEAHSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H371</accession>
    <name>A0A401H371_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1402850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619790.1">
        <property type="nucleotide sequence ID" value="XM_027763989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H371"/>
    <dbReference type="STRING" id="139825.A0A401H371"/>
    <dbReference type="GeneID" id="38785794"/>
    <dbReference type="InParanoid" id="A0A401H371"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="31"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="571" mass="63885" checksum="9E10F95C28361CEA" modified="2019-05-08" version="1">MEDIDRDQNASSEILEPVEWDSLRKLSLEPGGFRDKRTQLWPKLLYVTHVEEAPDPPESLDGSTLIDAASDNYTDLESTTESVHRDERQIGLDTERSFVLYPVDSTEDREHRQVELHELIVSVFRKRQRLNYFQGYHDVISVLFLTLPKELQAPCAEKLSLLRLRDSMGVSLEPVVGLLRILKRILHCGDPSFAALLERNMSLPYFALSHILTLLSHDVPSLPLIQHVFDYLLCRPPIAIVYLVAAVALSRREEVEILEKDGEDGMIHSLLSSLPELYEEDERALPIGEDISKSIVIVQAEESVEDEATARVNPVKVEPLQVEDMAEFPPDPEHARRKSNGSADKISPLAQEPDTLVESMDVDEISPGTPTTAASSTSSPSEKFRTPSPTPSIPIHIPQRPRVSLTSLFLRADELYTHYSPSHPSIALSSIMGPQSVMLTWSENSAELPTDDEAELMVTKPELVVRPYIEPEDEVVSDEEQTEKKDAERRRRRKPHKPRQLERAILERKTVVAGAVLVLGVAVVVYGMQSGQSGGGHHPHHTVSRELRRVSQFVGGVLLGMGERAFGVVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3D1</accession>
    <name>A0A401H3D1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1403200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619825.1">
        <property type="nucleotide sequence ID" value="XM_027764024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3D1"/>
    <dbReference type="STRING" id="139825.A0A401H3D1"/>
    <dbReference type="GeneID" id="38785829"/>
    <dbReference type="InParanoid" id="A0A401H3D1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="91419" checksum="55EAA7A2349E32B6" modified="2019-05-08" version="1">MKPIEVAEEKGEALTTSGRAQRAQKRMAQTEVEGSKVSTKKSGKRKAKESSDEEEVPTIKPPKKKRAMKEYKSKEFIESEDETPAPPSNLPAKTAGDSNDGVAKTNTPAKPVKQTTRMTATPHVAPKVKAKGKAKATAKGKATAKGKVTAKAKAKVTVSQKDMWKKTSTRVSDFMWAHATDSLVPCIGCQEKEWPCKLNTANFGRCLECAARGVSCSIALRNTDGVPLRGNSHTAQREFQEMCAALVVEGKPMPTSPSPYDVKVDSDEPDSAEPMVMGALKCKPPKKTKTRNAAASSSKVKGGEEVEATKQKATVTRYEANAEGEASVEKSSKSKRTTKSATATEAVALSNSGEVANSGEVSKSGTPAKSGAVAKPGEGKKSGPKPKPVRSQNSGAQDGGEVTRTSVREADEVPPAKSVAKEGGKAKASAPKAAAKMPLAEGDGMEEAARLAMEVVRAMAFQTGPAAPPQASSSKRMLTPVADEPEDAPEYQAEVAEDESASLERPHDDRRRSLLMPHETSAGAAKVAQEVTPSLEISKASKGVKSSTLVKAGHLDEGRRPAKRGAPLDCKAAKKEAEAKRDAKANRLRAVPPTSKAPHLRDVQQVSTGSPAPVNEGDTPSGEETSQSSNDDCANCAELRQEFLAHKDGMEVQFQERMADLNTVKAEITAALQRINPPSAFQENARSIHEEVKLAMEEFRRPVTIELQESMKLAVADLVAKRHCLPELKEKVNRLEQGANQTVSQADVDKLQGELADLHHSMELQAARSDSMEKELRSSAAEAIAQASKLEMELALAKEDSMAVATSALDEAKKVGKEVATAREETSLVVKSLDAFREKVDSAMVFTAFRPDSHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3I7</accession>
    <name>A0A401H3I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619918.1">
        <property type="nucleotide sequence ID" value="XM_027764117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3I7"/>
    <dbReference type="GeneID" id="38785922"/>
    <dbReference type="InParanoid" id="A0A401H3I7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="48521" checksum="788760E63DA6F0C8" modified="2019-05-08" version="1">MASDAEPPDTLDITMGESDEEDSIAEPCRPLISDLLDSPGSAQISLPLHSASQTPLAPRHTTPSLAAPFAPSNSPHEHLHCHASPKVQASSGSVAPVEGSRALIPDPLAPAWDESRGSSPIHRRALISDSTPTAPGGMFDFDTPGISPIPQRALLEATPLPPPAHTFDFRTPDTSQLPRRSLIAEPLDATSRTSIHFDSQASTPMARGMLVDETLDAEPVPKLLDFDNSPPATPGRRRALVIDSPGATPVRSQVRWLNSPSTSPPKRRPLLDDVLSPPPLPSVPSHSPARTFDDSNFRHDAPVIHYMKGSIEPVTVTSRMPSLAALPDELPIHRPTHWEQVPGLFPDTTQLLPMAVPGETNAASGSQVARLSRSFAQIAAEADSSMDDDEGDSFAVSRRRAMLRERIVRLQRELNLTEDMHVANLNASSTVFQMGYILRDIRGEAYRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3S6</accession>
    <name>A0A401H3S6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1500900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620000.1">
        <property type="nucleotide sequence ID" value="XM_027764199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3S6"/>
    <dbReference type="FunCoup" id="A0A401H3S6">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3S6"/>
    <dbReference type="GeneID" id="38786004"/>
    <dbReference type="InParanoid" id="A0A401H3S6"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="10">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="382" mass="43005" checksum="2BDC21D0A38BA1C5" modified="2019-05-08" version="1">MSISTPASAGPDIDFSYFGGAESLWEGRTPRRTEVILPTSKDNGKMHVAPPQDASDFLWIMTEEPHRSRRMAIIKAHPEVTKLMGHEPLTKWVVLGVVSLQFVIAYLLRHTSPFSPVFFACVYVIGATANHNLFLAIHEITHNLAFKSVRANKVLAVFANLPIGVPYSAAFKKYHIEHHKFLGEDGVDTDLPTNLELICLNNVLGKVFFATFQILFYAFRPTVVRSQTITTWHIMNLITQLVFDYVLMKCLGVRPFIYLLASSFFAGSLHPLAGHFIAEHYLWDGLEQETYSYYGPLNFFAYNVGYHNEHHDFPAVAWTRLPALRALAPEFYDTLPSHPSWPMVIINFIRDPEVGIFARAKRRAATKVSPGSGAPKTEKAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H491</accession>
    <name>A0A401H491_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1502420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620147.1">
        <property type="nucleotide sequence ID" value="XM_027764346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H491"/>
    <dbReference type="STRING" id="139825.A0A401H491"/>
    <dbReference type="GeneID" id="38786151"/>
    <dbReference type="InParanoid" id="A0A401H491"/>
    <dbReference type="OrthoDB" id="3266963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="379"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="733" mass="81637" checksum="E4E1CA93DAD52FB3" modified="2019-05-08" version="1">MAGSQTVFLSGEAQWEAARAASMDRILLAVQESGWTLGEFLKILFTVPQTQKEKGNPPRHAQMVSVFLQGRLAIKAQDIVELMYSSRYSAPLSVRKSANREASAVRRPDPKVMANWCLREWAISKAEAVVNKEAEELALRSTGFHLDDKTATWDFILNFSMESVLSTLHLKSPTLLRLLKAAAVPVKSSMRASGLSAVPLPTSPTPNTSNYPMPSEPHETVYNLSEHFSNPPPSGSGHNRHDPLVIIAVACMLLLSARNSHVTMFQKMVGVWLFAHTAPHGIYSVLGRVGLSVSYTTVLKLLGALSDSAKNSTRRSAQSRAFLLIYDNINRMARAWDPDLGQKDKIHNGTAATYVELADCDVEKAFDVGCLRQAQQEERRKKLSLDVLYKRIDWEKLNLCVTTHILRILVQHVDGLAKHRDFVQLRFRTTLAIHRMRAGRQTSLHPLATSDYNEGNTAENAKVLDDLILNQLKMGKDDVTKYMVIVGGDQSTVEKLRTLKRLVASCPHGYPQYGWVLPLIQLWHMGWADLERVLSTHWGKSTGDDLSSLRAANVLLGRKVKDQKRPDYYPALHLVFDNLDAEVLDCWRFPSQFPCHNNRPSAAGKGKVDGKAKAKAKAKPLDPAVIPSVSDMDSFLAQAGGSLRKRKTRPEPVYDKPRTSPPRATGDHRDSHPDYFDASSDRINDDGVGPSSDDQFLSPKEKTRKEAIDMTPATKRLERMNVHSGTDEGDTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4N8</accession>
    <name>A0A401H4N8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1600580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620310.1">
        <property type="nucleotide sequence ID" value="XM_027764509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4N8"/>
    <dbReference type="STRING" id="139825.A0A401H4N8"/>
    <dbReference type="GeneID" id="38786314"/>
    <dbReference type="InParanoid" id="A0A401H4N8"/>
    <dbReference type="OrthoDB" id="8054889at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="660"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1060" mass="122198" checksum="A37CCEA917A5459B" modified="2019-05-08" version="1">MATVTMDEGRHHVSQKELGFRKPEIFNSSDCSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETACTLLHNIKQGTRTADNYIAEFRSLESKAKLEDAENIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYTSRFDNQWRSAQIFKRGATTTTRGKGRPVHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLAETFMNIRFAEENDFIRWELPKPIKVMNADGTPNQMGTITHCTWKMMKIGGRKTLTCFLLTGIGKENILLGMPWLKRLNPMINWETGDFWFGKDAKWPPKPIVENAPDEEVSIFKEDGLPELINTKTSPISFGHSESIREIMADNTERGELPAVQNDTESDDPPSEPSMDQLDDNDLVISYIAGEPVIGIFEPIRKESPLMNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKKASAVDKPKTVEELVPNYLHDLKSVFEKKAAEHFPETRPWDHTIDLKPNFIPRDCKIYPLSLKEQGAMDDFLEENLQKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLIEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDDDQWKGAFKTNRELFKPMVMFFGLCNSPATFQMMMNVLFKDIIDEKWIVIYMDDILIFSNDLEEHHVRTRRILQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSSPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGTLNPAEWNYEIYDRELLGIIRALTEWRHYLEGSPHPIEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSRRNRLDDSESDNEDHVLLPNALFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4Z5</accession>
    <name>A0A401H4Z5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1601110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620362.1">
        <property type="nucleotide sequence ID" value="XM_027764561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4Z5"/>
    <dbReference type="FunCoup" id="A0A401H4Z5">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4Z5"/>
    <dbReference type="GeneID" id="38786366"/>
    <dbReference type="InParanoid" id="A0A401H4Z5"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="391" mass="44515" checksum="EC4681D9F338EAF6" modified="2019-05-08" version="1">MDPSLPLVVDNGTGFVKVGYAGSNFPEHVFPSIVGRPILRAEERVGSAVIKDIMVGDEAAENRNYLQVTQPMEHGIVRNWEDMKILWDYTFDEKLHVNTQGRKVLLTEPPMNPKANRQRMCQVMFEEYGFGGVYVAIQAVLTLYAQGLTTGVVVDSGDGVTHIVPVYDGFALPHLTRRLDIAGRDVTRYLIKLLLMRGYAFNRTADFETVREIKEKLCYVSYDLELDTRLSEETTVLVETYTLPDGRVIKIGSERFEAPECMFQPHLVDVEQPGIAEMLFETIQAAAVDIRAELYKHIVLSGGSSMYPGLPSRLEKEMKQLYLTRVLHGDPTRLNKFKIRIEDPPRRKHMVFLGGAVLADIMKNREEFWISREEWFEQGIRSLDKLGRGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H500</accession>
    <name>A0A401H500_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1601700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620421.1">
        <property type="nucleotide sequence ID" value="XM_027764620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H500"/>
    <dbReference type="STRING" id="139825.A0A401H500"/>
    <dbReference type="GeneID" id="38786425"/>
    <dbReference type="InParanoid" id="A0A401H500"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE89508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="525" mass="58479" checksum="65FED486ADBD73EB" modified="2019-05-08" version="1">MDEPIVKRLHVSGLTPAITPADLTQRLSSFGAVKAVDGFGVLDAVGLPRKFGYVTLETTKPKLARCMNTLSGVTWKGTKLRIGEAKLDFRERILKENETLKRAASDSPAGPPHKRRRLPRGVHGVHAQDMSLVTPGNAASRPGWRVTSLGRLIRPIRMRPEHPLPDQLPKIVSAEKGRKPQKERTQKKRVKNPPTRARRRTIDPTKWGSLHLKGVFLDTGATLDVGQRPPALRETERGLEESSNDEESDDDDDETDSGDEVMGAEEYPPSLLQEATLSPPFSPKPAAQKTRANVGDENDLVQETKKSLGLLQVLFGGRGDDEWGDQESVDSDGDLDDHARPADMQAEDIEENHMHVDKAVSFRVERVQPHEELPTPVSAQSAKLKDLFAPREEDAGFSLLGHLDLDLELDDEVDLQLTAEPQARPVPQPVATVSPAAGAQSVFDTRRPLFFPFPLDERDRARGRTGDAFDATNWRTWFYRTDSAEEIHKRWEETRGELTSGWKRRHREAVKSRRRRGGGAEDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5P4</accession>
    <name>A0A401H5P4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1700570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620645.1">
        <property type="nucleotide sequence ID" value="XM_027764844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5P4"/>
    <dbReference type="GeneID" id="38786649"/>
    <dbReference type="InParanoid" id="A0A401H5P4"/>
    <dbReference type="OrthoDB" id="5231159at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="96" mass="10944" checksum="7D2C7F70E09856D6" modified="2019-05-08" version="1">MTFRLLRKSAMSGSHPMATLAMAEFMLDKLADRPGFSRERIMRQMCDEYGADTEQKIVQFEQETIEQHGVGHTVLDSVASGVTLMAPRVMPARWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5T9</accession>
    <name>A0A401H5T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1701090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620697.1">
        <property type="nucleotide sequence ID" value="XM_027764896.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H5T9"/>
    <dbReference type="GeneID" id="38786701"/>
    <dbReference type="InParanoid" id="A0A401H5T9"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="2">
        <location>
            <begin position="94"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="2">
        <location>
            <begin position="472"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="2">
        <location>
            <begin position="790"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1420" mass="158059" checksum="35429EF4E671DED3" modified="2019-05-08" version="1">MRGGALRSIRWTQKFPKHPHSMAQRRLKHILNDLVAHPSVIGTLKLADISYDIHQSPTPTRLPHCEDALLDLQDHFNLDNLHFMLQKYLLGQDIFLLSQPGPYARHLAMTFCSLINSEYEYIALHRDIGETELKQGREIRAGGNLLYVDSPAVSAAKHGRVLIIEGIEKAERGIMPVLNNLLENREINLDDGTHVIHPHRYSLLDSSSTGTSAGKIFIPAHKNFRVIAIAAPVPPYPGYPLDPPFRSRFQARFVDPVGSLLTLSNSSASDNSPLFRTLRDIILSTQYASESRHALDAVAKSTLPAFPQTALRKLRALLSAFPPPEQLSSAQLARLMLTIHPALIHAPFIAWAMLSSKSEESGLGQLGSPSLTGNGDHLGLLGYYLSKIERVNERTARITFEGTEGASTVSLDVSAGPKKLLSFPFEDPDKLGFYATDRFMGLLASMLQAHALGWDISYVPPALPSTASCSTSLLVKTFGAVLGYELEGIHLYKELGGRELLMRRKIGDGGATNWEPSPLIQGAWTGRLVHLSGIDVIGSTAGSLARLIQDRETELWENKRIVSQASDEEQATGELSVAHPAFRIISTASKSLPLRDWLSDEHANMFFPVAAQPMGRDEEASILLHTGCSPSVVTTLLTFAEKYRSSMTSDSVQKNRKLGTRSLVRIARHVAKFPGHNDLHSLFSRSVLAEFLPTTEAMNLQELFEESGIKKRTPAFNPSPEIQDGGLLFPAPSDPNNASAEPIFIPFFDESQDAEGVASHVPHMDHFYDNSLQTGLMRDLAIDLEALGEHLVLLGNQGVGKNKIVDRLCQLLGRPREYIQLHRDTTVNQLMFQTVLEGGVIKYTDSPLLRAIKLGRVIVIDEADKAAEHVVAIFRSLAGYGQLTLPDGRRVCRERKREGDIVVHPKFRLILLANRPGYPFLGNHFLQVLGDNFSCHAVTNPDMSSERKLLSQLAPELSEDMILRLVAVFHDLRAAFDSGALTYPYSLRELINIVRHMQSYPKDSLETTLRNVFDFDVYKPDTIEKLAAILDHHGLAVKRLGIDAAREVSRKKIVDVQFEPKGRTDLSNPKFGKEDPNNEPHVGGNTWAGGTGGRDTAGLGGRGGYMRLFKGHDIKQISDELKNDVPDHIKEQAREMARQELARRLEELNMSAGEARGYGALLTAVGSHIAQLHDLLENLAAKEEERVWVKRQTDGELDDSRLTEGLTGEATVYKRRGMAKPEMGRPQIKPKRIRFLFDISASMYRFQYDGRLKRSMETAVMLMETFDRLTRKDKYVWDIYGHSGDSAEIPLVEFDKPPAELRDRWKVVEKMEMVTQYTFAGDYTTEAIDKAVTEVAKFDADDWFVIAVTDANFARYNITAEDLQRVMTRQPKVNTALICIGEGAEAAWIPQKLQGRGFRVSNTADIPTVLRSILSTMVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H666</accession>
    <name>A0A401H666_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4100 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1702090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620796.1">
        <property type="nucleotide sequence ID" value="XM_027764995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H666"/>
    <dbReference type="GeneID" id="38786800"/>
    <dbReference type="InParanoid" id="A0A401H666"/>
    <dbReference type="OrthoDB" id="3253434at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025165">
        <property type="entry name" value="DUF4100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13352">
        <property type="entry name" value="DUF4100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4100" evidence="2">
        <location>
            <begin position="664"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121417" checksum="4227D9E2B4515F1C" modified="2019-05-08" version="1">MTPSRWTKEGPSGSTFHELVVLPTLAPGLARSAGAELSDECSPSPLCDATTQAVLSDSHMANAPSQPVSHRSEASSSVPAGGPSQDALKCLFFVLVSTAHVKMVPNGHTVKYQKHEENKTLTEKVTVLALSRMEFIRVVLSAHGLENFYLPGLLNGPGMKVHWKGSSGGKTKAPMIHMDNDWKVLLQQLEVTRPNQVHTVFVDFDLDTMEGYKNRKHPLSPFSLDSQFNAAELSYGTHVPNAALYSPEQRAQAAMVDDIKAAWQCMQHGTCYINTAQEHIQMNKFRLKQWCAAIAANASSAKEPPPDSLISEWTGKTVMAAKPCGRCGPNVVTSGSGFDDPGSSSETTTNLLISTLGFLVTMMAQNNTKQNMPVSIPPTILAPAPLPLDSGGPASLSVSSTAASVSDTAAAGGEVTAHARGHTASSPPPIVEEELVHCLEAFGRAKKIPLGIIDMVLGKLFELSYSPDLLTEVSVERLKELTELPEGQVYALKKFAGEWCCKVGQVLSIMNQTPNTSSTFIPISMPRPGGKGTPSLNGKHVQDFISDFESAAKAAGIANTEWLKLVLWYCDLKVRRIIENDAAFTGTVWADARAQLTYYYESSDHKPKVSPRQLRAFVKKVKKERVRDLRDFDNYVRIFANKVSDMVTKGQLSDTDRNLAFYKGVPKRLRKKLKASIETAAGHKLTSHRPPMVGQVVQVARNYFKEDDINYDSDSSSSSSLDLETGSGDSSDSDSDTDSSSDAESDDEKPRKKKKKSKKKKTKGKAESMDADNKKISQLQDKIDKLTMHLVNTEDGWHERECRKCEERLQPQDEQTSPVSRPFKPTNYRFMSNIQENVSIDQVQEQLLDTKVTLPLRNILGASSELQKRFASLTKMRKEFGVKASIYDCDEVDEDNTSVDMPQSGKEQTAQVLLTFSTKDDLMHILGRYAGAVSLGAKRFFAMACGVVQAKFGTKDVTFLVDSGWELNLVSRCIFDQSGVNIDEDGACWSLRGIYGNPVPLLGCCRDAHIEIRSKRFDHHFFISHSETGNHDGILGQPWLQWFAAHIDYERAGSMTLQAFPSGCKSDESVNIMVVGPDHQRNADRLVHATIADVPDSESEAGPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G548</accession>
    <name>A0A401G548_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0101600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608200.1">
        <property type="nucleotide sequence ID" value="XM_027752399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G548"/>
    <dbReference type="FunCoup" id="A0A401G548">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G548"/>
    <dbReference type="GeneID" id="38774204"/>
    <dbReference type="InParanoid" id="A0A401G548"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF4">
        <property type="entry name" value="AMIDASE C550.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="171"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="629" mass="68629" checksum="311F91F63D55C16B" modified="2019-05-08" version="1">MFGGGRITRLAEKEALLGAEGLGEAEAVISKCACQVDYMVVGVCISSKMPIRHTLACCKVLTGDFAAEFLIQITDFLMRQRATIMAPQTKLLQATGDAAYTAKAQSLIASLDAEIPASLRLPASILENLPLDVTGIPRSCGLLTPAELTITELDATEVCARIARGELTAVETVTAFGRRAAIAHQLTACLTNYFLDEGIARAKELDEYFQREGKVVGPLHGLPVSIKNHFPIKGRTGFAGFLSTFEVSPDDCDMTRILRSLGAVFYVKTNQPQTLMHLESHSFYGRTLNPYNTNLSSGGSSGGEGALIALRGSCIGVGSDGGGSIRNPSANCSIYGIRPTTKTMPADGFLWYQDGQSFASSTGPMCRSARDIQTFLYAIHSAKPSLINPLLIPLPLVVPSLEGQKLRVGFMMHDDVVLPHPPMLRALQMAREKLLAALDVELVEYKPYDHDRGYSLIREWYFEDGGETVRRLLKEGGEDSLPLTDWVISPPYTKNHTPAEMWALGDKVDKYRREYSDHWRASGIDVLLCAPFPGTANPHDNARYWGYTAVWNLLDYPGVVFPSGLKADPAIDLAQEQINPMSPSDSYNHSLYVPEVFVGAPISLQLLARRFNDGLLLAAQNIIEGVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5N4</accession>
    <name>A0A401G5N4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Inositol phosphosphingolipid phospholipase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0103380</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608376.1">
        <property type="nucleotide sequence ID" value="XM_027752575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5N4"/>
    <dbReference type="FunCoup" id="A0A401G5N4">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5N4"/>
    <dbReference type="GeneID" id="38774380"/>
    <dbReference type="InParanoid" id="A0A401G5N4"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE77463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="450" mass="49437" checksum="F665B911B0B28EC7" modified="2019-05-08" version="1">MSDDRLRVFTFNCWGLKYVSKNRAERISAIADALVASDYDLITLQEVWVFADYELIRAAVSKRLPYSKFFYSGAFGAGLAILSRFPIIATTIHSYTLNGSPIDVIQGDWFVGKAAGSALIAHPILGQVQVFDTHLYAPGGDSGPIHQQAHRYVNAWEFAKLTRQAADVGRYVIAAGDFNSIPSSVPMAIISEHAGLTDAWVATHPNAPVQTLAGPSPALTSPHDAIRLYGVTADSPLNTYSAGKHLEPVARKYQGKRLDYIFYRQPSISPPSGRNPILKCVDTNVVFTQTIPRANFSFSDHFGVEATFEISRPENGDIETHVAAPAEPGSVLTPPPIPNPSLSPDSINRTLSSLTSRYRYAQHRGRSQLTVFGSCTSVIIFMALGSAWLPQSWINPIFVVATIFLSWLATTMFYVGFVYTKWETNALTNVIEELEIYRDSLEGLDGRNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5X9</accession>
    <name>A0A401G5X9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608491.1">
        <property type="nucleotide sequence ID" value="XM_027752690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5X9"/>
    <dbReference type="GeneID" id="38774495"/>
    <dbReference type="InParanoid" id="A0A401G5X9"/>
    <dbReference type="OrthoDB" id="3242001at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="396" mass="44209" checksum="9778AD5005429132" modified="2019-05-08" version="1">MSECNSLLKPLAGSVNRVQGTSISSGSSFTTRVSVDTAISSSSRIAIPLHLDAPPSRTSDAAVFAAYQRWKTANEASGALPDMKRAVAQCKTEADSAKARLEGMKTQSTGLQRKPSIMRKIVGKAKKDQSTGGTELLSTGITEARCSKEDAERRLATLSDQLRAFETVAGMLDGYYDTLKSMMVSKHLLAWRYSLASEAAISRAEKVVAEVEGAYTDSQRMTNILQRVELAIQSTHHHYRNAMNDLDAVCGARRSKWESLLADEQSKEMTYKAAAVWAQKAQKCFDEFLRVFDAHRDLLGNEPQERHELKQVGLLQAVQIYKLNYGGKPLQMGIIKEMEVMLQKQEAVFQRLTALAVWVQDFTKHSETVCQDVRVKRDRARHKLVVVWMDDSMPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6M4</accession>
    <name>A0A401G6M4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor cbf11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0107040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608735.1">
        <property type="nucleotide sequence ID" value="XM_027752934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6M4"/>
    <dbReference type="FunCoup" id="A0A401G6M4">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6M4"/>
    <dbReference type="GeneID" id="38774739"/>
    <dbReference type="InParanoid" id="A0A401G6M4"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="163"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="295"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="79072" checksum="7D72391EAB9924A3" modified="2019-05-08" version="1">MRTISSLDSPPVHLQMPPATITDSHVHLAPPLTHHDLSRSPSPQSDLSLLVSDRHHPPLHSADPAILHATDPSGRTALSVHSLLTGPHQAPSNTRTQTTWSSPMPPPPPPRDGNAVPGPSTPTQRPNKRRLDASDGEDPASKIRRVVRDHVTQDPARVLPMTTVLCLHAAVAQKSYGTEKRFLCPPPVVHIEGPDWHLKQQQLSMAVVSEGGDRGCEQKAPLDHNLTASFKFLHVNGTAKAKSFQLSLDIAEPPPPVQEGSDPGRGRVWASFDSAPVTIISKPSKKTAKTRNISSCILAGGPVSLFNRINSQTVRTKYMTVDNSQLCASNVSWSAFNVNVIRSTASPLPESHVAGGPQPVTYGSEVVLADTVSGTQTAPLIIRKVDKGRIVQDDNGPVSQMQKVALQRKDDDGSRQYLSAAGPMPGTPGTVVPPTPGLSNQAGSHPLLFQAPRSREEIRDGGLSFMYDEVDDYLCWTIVGISKFQYTFFDALGQNSTIPDLPITPFPTLFSAPLYRTQSHTMELTASNFFYENPKTRTQLPLDIYIGNIGPLRFRIYPPPDPETSMGSAHNVFMQPPTEPTHGPNGEPLPPFVPMFIPTAARYMPMGATHTILIVEMPPINNILKSLMEDALSTEESDGESPRSGEATSAGQRKVDASSIIGRSLPILFIRSFDGVGYHSGRAVQAENVFQNIDLSGPNPATSAMDPSWISAAHHAASTVDGGLHGWTIRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6S3</accession>
    <name>A0A401G6S3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phytase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0107470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608778.1">
        <property type="nucleotide sequence ID" value="XM_027752977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6S3"/>
    <dbReference type="FunCoup" id="A0A401G6S3">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6S3"/>
    <dbReference type="GeneID" id="38774782"/>
    <dbReference type="InParanoid" id="A0A401G6S3"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019462065" evidence="2">
        <location>
            <begin position="17"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="548" mass="59108" checksum="C3784D6453595925" modified="2019-05-08" version="1">MLNTVLLLASLTLVLAAPTIDPASSIAGSTVSFSFPPAGATFTAYEAYFPGASEVGYPGPTPTGDEAEAIQTAPAAALNLDAYPLVNPLAQYTGDVPSFNTLHHWGNLGPWYSVGEAFGLPGASPQIPAGCELTQVHLLHRHGARYPTSGSDPGQFAAFVHSAAEGAGFTATGPLEFLNSWTYKLGAEILTPFGREQLYELGVGFRVKYGELLKGFNALPVWRTTSEERMVDSALQFAAGFFGVQQYQNSYYEEIIVENSGFNNTLSPWNACPNSNNAVGNLGGVYSGNWTDIYLNGTVERLQKYVTGLELNTNYVFGMQQLCAYETVALGYSDFCDIFTVEEWLGFEYANDLSFWYSNGPGSPVAAAQGIGYVQELVSRLTQTPLTVFDTSTNGTLDGNPVTFPLNQPIYVDATHDTVIAQIVTALNFTTLAANGPLPVDHIPAYQTYHVNQIAPFGSNLVGQVVSCPASPQNATQESFIRFILNDGVVPLTGIAHCETPNPDGLCPVANFVQGMQERIAQVNFNYDCFADYPAPYPDDIIDGREWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G714</accession>
    <name>A0A401G714_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0108360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608867.1">
        <property type="nucleotide sequence ID" value="XM_027753066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G714"/>
    <dbReference type="GeneID" id="38774871"/>
    <dbReference type="InParanoid" id="A0A401G714"/>
    <dbReference type="OrthoDB" id="3226250at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="562" mass="64164" checksum="02D719A751EC6473" modified="2019-05-08" version="1">MDLLDQPFGPYRDGDILTETCKSVPTGVLELENVMLECGGEPIGLTECEPCQPEYAVSRIRAYGVRFRGVLKVKKLTWLTPWARKVLEDDVRNRDVQSRISSGGVARSTLTLDNIYARRLTIKVVVQGVKNMPAIYLFSKLVPNGLLLTSRDRNRQYEVKTMDVSTYKPSRLHLHRYRTLKVMQQLIKLDKQTNTDDPDGTPVIERTVFWFADLYLKHMAYAASASKQRFVYTSSDSDIEPDTNGQLKEGRQRTLRHLPRAEVLSLLATHAEWILADHSKRKKKYLNQDAWAEWVVDVRRGRREARNADVRWGVMDDAQLPATLTPEGSDADEDDIPAMPRRRGKAKKQKKQTQTPSSRTLSTASGSRSTTHHDVSRYGKNTSINAPNPTTLRTYDSDFSPESTPPASPSSSSASLPSRPSTPPNPEIMALLPIEFMYPPLLPLHFRWVCPAADCRYMINLLDMSDENCKALSDEDVRKMKAGGWVIRDRWVRRCFKTMVSAHYDDHLDQMGIVMWQEKKQWKIGWKKPQHHPPWPPRRELPATSHKGVKIEEEDVSLESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G727</accession>
    <name>A0A401G727_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrofolate reductase</fullName>
            <ecNumber evidence="2">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0108520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608883.1">
        <property type="nucleotide sequence ID" value="XM_027753082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G727"/>
    <dbReference type="STRING" id="139825.A0A401G727"/>
    <dbReference type="GeneID" id="38774887"/>
    <dbReference type="InParanoid" id="A0A401G727"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046452">
        <property type="term" value="P:dihydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069:SF3">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00070">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="8">
        <location>
            <begin position="3"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="213" mass="23859" checksum="28701E8CDE1CB0FF" modified="2019-05-08" version="1">MTRLTIIVAATLTNGIGHNSRLPWRLSKEMAYFARITSNAPEGAMNTVLMGRNTWESIPPKFRPLPKRINVVLSSNKHYELMPSDAATPPVPVYLHSNLQSALARLSHPEWLETPVHRSFVIGGAALYRETLSLSPSSESFVDRILLTRIVSPAFEQCDVHMPDFQSVGVSSDDSLPWRRASHEELQSWAGFDVPAGSQVEAGVEYEFQMWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7J6</accession>
    <name>A0A401G7J6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0110250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609055.1">
        <property type="nucleotide sequence ID" value="XM_027753254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7J6"/>
    <dbReference type="FunCoup" id="A0A401G7J6">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7J6"/>
    <dbReference type="GeneID" id="38775059"/>
    <dbReference type="InParanoid" id="A0A401G7J6"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="386" mass="43525" checksum="72E2C8CA585ACA4A" modified="2019-05-08" version="1">MPSDQSTWLIAVPADGDSLSSLQAKLPNGGKSPNLAPLPLPQFKTGTLESLVSLSEELPKYDASFTATVAKSVDTLRNLLNNDPAKLAQHIQVNEEPVDTYLLHHWHWNDGRYGTQRPIKDMVDVLNKEMSSIDNVMKVKLNTYNLAKGQLVQLQRKKTGNLSVRSLADVVHRDNFVLDSEFLETVLVAVPRNLVKDWTAKYERLAPLVVPRSATQLAADDEYALFAVVLFKKSHDAFAHQCRESRYVVRDFAYSDALLERQREELASADSAEKELWTELLRLARTNFSEAFQILVHLKVLRLFVESVLRYGLPASYSAFFVKPEPKATKRTLSALQTHFARLGRRASNAKTNAKTDGGEGAGEYQALLEQEYFDFVLFEVPWIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G882</accession>
    <name>A0A401G882_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0112700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609298.1">
        <property type="nucleotide sequence ID" value="XM_027753497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G882"/>
    <dbReference type="FunCoup" id="A0A401G882">
        <property type="interactions" value="743"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G882"/>
    <dbReference type="GeneID" id="38775302"/>
    <dbReference type="InParanoid" id="A0A401G882"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="114"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="210"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="214"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="439" mass="50216" checksum="6522D9D707A40792" modified="2019-05-08" version="1">MKDVSTASKAARPSAYPKKRPSPYGISKSRKSPLYPPSLLVRRTPRAARAEMTAQRQRNAQILALRRQGIYLEEEYQDEIRAYMHEMERHTTCSITSMDQQPEIRWHMRPCLVDFLVEIHFTFRLRPETLYLALNIIDRYVSRRIVYVKHYQLVGCAALWIAAKFEDAKDRVPSIEDLVQICGKGTYDQIAFIQMEGHVLQTIQWSLGHPTAEAWLRLLCADRWLEETRVQHVARFLMEITLFYREFVRCLPSSIALGSLTLARYLCGKARRAFEETEECLEVVELLDNRLSKHVNHLSETLVRKYSFAFFSKAATLVVHYYLHGGRFVRQPSLSFPMTPVRSHSANIVSTPMSVSTTASDFSDDMPATPTSPMFSSDPFSGSCLSDDKENLPSPIFEPIIHKIPAEPIPDQFLPHDFVTLSRPALHSLNVSPRATVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G886</accession>
    <name>A0A401G886_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0112440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609272.1">
        <property type="nucleotide sequence ID" value="XM_027753471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G886"/>
    <dbReference type="GeneID" id="38775276"/>
    <dbReference type="InParanoid" id="A0A401G886"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="258" mass="28301" checksum="E14209C80995F914" modified="2019-05-08" version="1">MVAGSDDEYGDHDLALSVADCKDIDHVTAEAFAMLSVASLPSRPARRALGGFTSAQRQHSSPREATMRCEPQLALLDAGPLHHPICEGPLDIPVEVNGKKIYQLEEACETGITDHWYKAAAMQFYRGAKFYSSPVEEKKYDSAAAPTHRYREGEKKYVIYHGLAPRPGIYATWPYQKREYLEDACAIRGFVATLPPAAKLECTPYSLSSIGINTLEDRQGPHDVSLLSSPTSVFRMPAYSTPQSPVQGTVRSLPSAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8D1</accession>
    <name>A0A401G8D1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0113190</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609344.1">
        <property type="nucleotide sequence ID" value="XM_027753543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8D1"/>
    <dbReference type="FunCoup" id="A0A401G8D1">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8D1"/>
    <dbReference type="GeneID" id="38775348"/>
    <dbReference type="InParanoid" id="A0A401G8D1"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
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    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="17">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
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        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
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        <location>
            <begin position="139"/>
            <end position="160"/>
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            <dbReference type="ARBA" id="ARBA00004906"/>
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            <dbReference type="PROSITE" id="PS51698"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="504" mass="54190" checksum="F798462288175299" modified="2019-05-08" version="1">MFFCSISGEPPQDPVVSQKSGHVYERRLILKYITENGTDPITGEKLEESDLITVKANPKAAPPRPPTATSIPALLHTLQNEWDAVMLETFTLKQQYNSLRQELSYALYAQDAATRVVARLIRERDAAREALASVSATMGVAPSTNGGDVEMTEGGQEASALPEDVLSRIDETNEKLSAARKKRKAPAGYATPADVKTFTAKHTIPSLHSPSPAGITALAVSQANPSQFLTGGNDKVVQLYDRSTDKVLALLKGHTKKVTHVAFREQSGEPTLLLSASADKNAKIWAHDEASGEYIPRATIRTHKGELTGLAVHPTSTLVALSSADRTYSLHDLTSGNAVYRSPAADEPFASLSVHPDGTLLALGTPASTIQIYDVRSGAVVAALTPPDSVPFTVNTLSFSENGYHLLAPDSLSSLAVWDLRKPKIMHSIALGEGFKVNKVAYDYSALLLGVAGSEGARVYAHKTWEELVRFEEGGEVADIVFGQESKEIWGASGREVRIWGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8E3</accession>
    <name>A0A401G8E3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0113300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027753553.1"/>
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    <dbReference type="OrthoDB" id="268594at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="7">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="1"/>
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    </feature>
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            <begin position="77"/>
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            <begin position="97"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE78441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="106" mass="11791" checksum="93C3011FEDA479DE" modified="2019-05-08" version="1">MSFGRPPSVSAGFQSAPPDRGSFPLDHYGECKDFMKVYLDCLRKNSSNSTPCRHLNREYLDCRMDRGLMGRDEWRNLGLDNLQSSPPETSPEGSVKNAPNNAPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9F6</accession>
    <name>A0A401G9F6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0116810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609701.1">
        <property type="nucleotide sequence ID" value="XM_027753900.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9F6"/>
    <dbReference type="GeneID" id="38775705"/>
    <dbReference type="InParanoid" id="A0A401G9F6"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="16"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="1293"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1212"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="692"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1572" mass="167199" checksum="FCB9A19DAAED2B3D" modified="2019-05-08" version="1">MDATELGRWTRFAAKGGIGKCTALQDCVAEESEDLMFMKDDEITVLMRLPEKDDLYLGYCEGVVGRFSGSDVQFHSRLKKPVIAKRSSSLASTRSRRSSSQSATALSARDTASPALAAQLTHSYSMSTVSSSGSPRAPRFPRSASASASPSPHASPLRVQSALQDEDRARSASHSSISTALESAPISPADFPRDEVRVASAASSHHPGSPAIRAPALSPLALPEEPSAKRSPLTPDTFIDTNTREATEEPSENVSLRLHDESYSVYDETDASARISVALSDGELGIGLSLLQDFMGGHDGSGSGSGDDASFASSSRQSGTETPPVEERTPSPSTSPNTSAGSPPDAPAPRTDVDRPARALSQYSASALPPSPSRASLRPSLHDSEAGGSEWEGASDIYDNYRYSRFSVASRASRMSKGSLLSLASGPAVPPVPPDLHGPVRERPSGEFGERVGSGGPSVESFRERTRSGSGSAGQSSVDPVVDHPPLNVVNASERAARAKPSPLSLVSEPSPFPLLHAAFGSPAQSPTPGSSESFASTFPSAIYPAGAGGAASAARQRLELERGPRTMNPVVRERDEEAVRADDRKAFGRNIVAEDDNSVEPSSAPPPPYTPLSPHPPSPRRLTPSPLSPSFPHQPPQNSQSNQNNTPPAARPLNSPSPQPLAPSPLSPSFPRQTSQSSQNNQNNAPPTPRLLNSPSPQSLASSPLSPSFPHQPPQSSQSTRNNASPAPRPLNLNRPPPSPNARTSLFLPHPHAPKPTHSPAGPLYGRQPVPSPSHFPSHVGPPPGSVVHALQLALSTGRPRQTTIYGLFEHDLASAVGPVPISFGLEPQMNVPAHRPGVSRSLRGSLVSSPPLPAEAAESERAMPQTAETGAESEGPAKAIPRANFFPQVSTVRPRSRSFSGFDTPFEPGALPNERSQEEGGLRASSPSMPMLTKRSKSALAAVPMAPVSLPAPQRATVSHSATVVRAVHAPSPLSLSQNNVVAAYPHAPSPQPSPNPSPNPSTRSAVTSPVALSPPGTPVAATLQQGGSGGPHAKSAAAVAAEPVMPPHSTIGTILEDERAPRSSLTPKFPPIKANSVPVIRHSKSFVTSSPGKTTTAAELPPRSMSSQGRRSGEDAKRVDDMVSIMSSLASGPSRPTQGLSRISTSTSALRVQLLQHEERSPSSSVRSFERDQKTVQVEDMDFEMVRPGIPQSPLAENSVDSLPLPSALQERANPTSGELPAPPPPSPHAVVRTSYVDQAPPESRPHKVMDAADIEAHRQRELRWISTMSSVSPSQARKSKKVRKMVLEGVPASVRYLVWAHLTDSKAKRMEGLYTRLLQREKVAASADIERDVRQLSVHLPVMHDDSLMNVLQAYLSMVPDIQYSRGLCSIASQLLLLSPEEDAFWTFISLMDTHLRPYFSSNAIQLDVDAALFGKAVEANDSALAKKIFLDMAVSPISVCRPWFTSLFVGALSPEYFHRVWDVFLFEGVPFLFRIGIALLTCCRQLLLKCAGHDPLFAILSHPPANYLPRTPDALIDLALSVKLKDEDIRKQRSKLEAQVKRQTQSRVLSSALPAGISVPAISLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9W5</accession>
    <name>A0A401G9W5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0201360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609852.1">
        <property type="nucleotide sequence ID" value="XM_027754051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9W5"/>
    <dbReference type="STRING" id="139825.A0A401G9W5"/>
    <dbReference type="GeneID" id="38775856"/>
    <dbReference type="InParanoid" id="A0A401G9W5"/>
    <dbReference type="OrthoDB" id="3268424at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="6">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="15215" checksum="34DE948188C224A9" modified="2019-05-08" version="1">MFDNLLGRNISKTADERDELTRYLSTNTKEVQDAVAWWYARRVEFSCLARMAMNYLTIPATSVNVERLFSKRPLLLPHIRNGLSAQSVHALLCLAEWSRLGFVRDTDVLAITSGPEGEGEDDGLGDGWDNIIMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAC6</accession>
    <name>A0A401GAC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0203310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610047.1">
        <property type="nucleotide sequence ID" value="XM_027754246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAC6"/>
    <dbReference type="STRING" id="139825.A0A401GAC6"/>
    <dbReference type="GeneID" id="38776051"/>
    <dbReference type="InParanoid" id="A0A401GAC6"/>
    <dbReference type="OrthoDB" id="3181669at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="53108" checksum="C5102D6A1A0E8796" modified="2019-05-08" version="1">MTYGGALSGLEDVVGEMERVRDLAVSAVKSGPTMQQFWECFTRPAPKLESFVVFDPQTQRSPAGPVTRVPPVLFRGETPSLQRLELRQCTWCWASTLFCSTVTSLILDGRKIWIRPRVEEILVALERMPMLEVAVLDQITPDIPWDFYPTSGKGRVVHLAHLKYLFIDGLALNCATLLYQIELPSHTRLCIYCQPFSRYKEFYAVACAIRTKYQGLSDASENLLRSFTFVPLTAEGLRLRAWTTIIPVEELRNRPATDASLEMRLAWNGASPSNSVESLRFACKALPLHTVRTFYVPGYFSLDSAEWVEIFESMQSLEELWVYGQTANHLPSALRKKVLCSCGTHLVQEDIDEADHSSDEEDEEAQPTYSFLFPALRVLKLEGVDFAGDERSKEEIQIYVYRCRNFILEQSVDLELMGAKVHWNGQELLDFDLSEIDSDASAEDYEDYYDDDEDVSEDDDDDDSSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAK1</accession>
    <name>A0A401GAK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Electron transfer protein 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0203700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610086.1">
        <property type="nucleotide sequence ID" value="XM_027754285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAK1"/>
    <dbReference type="FunCoup" id="A0A401GAK1">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAK1"/>
    <dbReference type="GeneID" id="38776090"/>
    <dbReference type="InParanoid" id="A0A401GAK1"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="447" mass="49373" checksum="365FCD8702ECF97A" modified="2019-05-08" version="1">MPLDRLLRGGLWSQGGNLTLRALRASHRHPFDPRFFSGNAPAAPAELPVLSPPSVAGWLLFSSALVFAVIVVGGVTRLTESGLSITEWRPITGILPPLSQAQWDEEFEKYKATPEFKLLNHSITVNEFKNIFYMEWGHRILGRVIGVAFVMPLVYFVARKKLTATLPIQLTGMAILIGLQGVLGWYMVKSGLEDSLMETPGAVPRVSQYRLAAHLGTALVLYAGMFGSGLSALYDWRYSKTGTWSGLKGEGTQWQAVLENPQIRRFMRYSKALTALVFLTALSGAFVAGLDAGLLYNEFPLMGGRIAPPQDELFSREYAKAPDGSDLWWRNIFENPTTVQFNHRCLAITTYAATYWMYHMTSKPALRAVLPPLARRMVIAAWAMANVQVLLGISTLLYLVPVPLAAAHQAGSVMLLTTMLQVLVSLRKPGMAAKLWRQALQAQKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAS6</accession>
    <name>A0A401GAS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610172.1">
        <property type="nucleotide sequence ID" value="XM_027754371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAS6"/>
    <dbReference type="GeneID" id="38776176"/>
    <dbReference type="InParanoid" id="A0A401GAS6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="117" mass="13119" checksum="084C0449F9C0F742" modified="2019-05-08" version="1">MEWRYLKDQWKMHFQRPGGAESVSLHLFSTIAPIASTTSTASVIIGPSDSGPHIHFTKKSKDFITSHKKRSAMKNATASVCTRETAREKGLKKVGEDKKEKGKAKEKDREQDPDDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB62</accession>
    <name>A0A401GB62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0205710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610286.1">
        <property type="nucleotide sequence ID" value="XM_027754485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB62"/>
    <dbReference type="FunCoup" id="A0A401GB62">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB62"/>
    <dbReference type="GeneID" id="38776290"/>
    <dbReference type="InParanoid" id="A0A401GB62"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="399" mass="42999" checksum="1AB286E73F14F417" modified="2019-05-08" version="1">MALLDAPGLTNVAAPIRSTSLPAGAYVLSIISLPSSYAVSASAPNNAIHLFNKSHLHHFQTLPGHQDAITDLKSVIHFAGATSPILISCGKDGVVKAWDDRTQSAALQMSTSSSGRHRPLLSCDVSSDGFLVAAGTDFQGEDASILYWDPRNAAAPLRVHSSTHSDDITALHFLHTSSFTPHSSRTLLSASSDGLVCTSNADEEDEDEAGLHVGNWGCSVARVGWVHRQSGSPGIWASSDMETFSIWSSELDLVRDVDIRQPSIHRQDLTWVTDYLIGCHNHHHIPADEDNDLSIFVGSNEGDIASISRSSFSDPNAPWLLTNTWSTGHTGVVRSVLWDERNNVLLTGGEDSRLNVWSSPAVPLSASRGQPAKLKRKSEDNAMDVDADEDVALLKKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB68</accession>
    <name>A0A401GB68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-dependent RNA helicase DBP8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0206120</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610327.1">
        <property type="nucleotide sequence ID" value="XM_027754526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB68"/>
    <dbReference type="FunCoup" id="A0A401GB68">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB68"/>
    <dbReference type="GeneID" id="38776331"/>
    <dbReference type="InParanoid" id="A0A401GB68"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="135"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="374"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE79414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="567" mass="62793" checksum="F071535387DA3F80" modified="2019-05-08" version="1">MAGAKRRNLTTDDLLRMQEEPNRKRGRTDLPPQDTAATSNSEDEQSVASTSDSDHEPVDSDDSILSSRTETIGDDTPSSRINFVPRTARVVPPDAPKAAVFRPSTFASLGVSSALVDALSKISIRLPTEIQTACIPPLLQGEDCIGNAQTGSGKTIAFALPIIHKLSVDPYGIFALVLTPTRELAFQISEQFAVLGASFNLRTAVVVGGMDMMSQALELDKRPHVVVATPGRIVDHLKSTSGEWNLARIKFLVLDEADRLLTPTFTPELSYLFEILPKERQTCLFTATLTPAVETLAETSPRPGKQKPFIHRIAETVETVETLKQHYVLVPSQVREAYLFHLLCNPPESTLHLRRAPPELVNRGQKASSKTKKSAKKKPTVGEEDDIEQPPPTIIFCRHPRTAAYLTYLLKSLNVRSTALHSRLTQRERLSSLSLFRASVVPVLVSTDVGARGLDIEDVAIVINWDMPDEPEEYTHRVGRTARAGKGGIAISFVTERDEERVLKVEERIKTKLTEMTLPEKKVLEKLNVVSTAKRLANMELHDSDFGKREEIHKIKKAKRKTDVEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBE5</accession>
    <name>A0A401GBE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endopolyphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0206530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610366.1">
        <property type="nucleotide sequence ID" value="XM_027754565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBE5"/>
    <dbReference type="FunCoup" id="A0A401GBE5">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBE5"/>
    <dbReference type="GeneID" id="38776370"/>
    <dbReference type="InParanoid" id="A0A401GBE5"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019338731" description="Endopolyphosphatase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="14">
        <location>
            <begin position="41"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE79453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="563" mass="64703" checksum="23CC156A9F3A7538" modified="2019-05-08" version="1">MLEFKLLSLLLLTCLPDGFAAPVQVPLQVPATRQRRKLQGRFLHITDMHPDGHFQVDASEKSSCHRKKPRKAKRRSGYFGMPFSNCDAPFTLTNYTLDFLDKEWSSEIDFVVWTGDSARHDNDRKIPRTTAEIYGLNRAITKRMEEVFTSKGIPVVPSIGNNDVWPHNIMMPGPNSITFEFSSIWRSFMPFESYQVFQRGGYYSVEVIPDSLAVISLNTMYFYDSNKAVGGCEYTDPEDPGNLQFDWLEVQLDIFRRRGMQVWLTGHVPPSSNNFFPDCYVRYAELSLRYQDTILGHLYGHMNADHFFFMDAETISSTSVPSLTDDPDEIDTLGRKKELYDTLIRTFADLPKGTKNISYDDYGVVNVSPSVVPNPYLPSFRIFTYNITGSQYVPKAQDEEEGTLQASNSISLAGRAASCNDSMHRNTWRCQLTQPWHSNPHSPSRSNNLWSPLGFAQYYLPDLEFGTAKRPPKYKLEYLTYQIAQLHPPEKKAGLKPYYPIPLRHLPKSLRDPNRTESKFAPYELADLTIPSWTELAQRLGEQGEKKLRRRFRRYMFMGSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBF2</accession>
    <name>A0A401GBF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Transposon Tf2-9 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SCP_0206940</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610407.1">
        <property type="nucleotide sequence ID" value="XM_027754606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBF2"/>
    <dbReference type="STRING" id="139825.A0A401GBF2"/>
    <dbReference type="GeneID" id="38776411"/>
    <dbReference type="InParanoid" id="A0A401GBF2"/>
    <dbReference type="OrthoDB" id="5100833at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="21">
        <location>
            <begin position="295"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="849"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="20">
        <location>
            <begin position="1148"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GBE79494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1202" mass="137714" checksum="D58DC3EF7DB98315" modified="2019-05-08" version="1">MGTITHCTWKMMKIGGRKTLTRFLLTGIGKENILLGMPWLKRLNPMINWETGDFWFGKDAKWPPKPTVEDAPDEEVSIFKEDGLPELITTETSPTSFGHSESIKEIMADNTERGELPAVRNDTEPVDPLSEPAMDQLDDDDLVISYIAGEPVIGIFEPIRKESSLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYIPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFIGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGTSIFTKMDLRSGYNNVRIKDGDQWKGTFKTNRRLFEPMVMFFGLCNSPATFQMMMNALFKDMVDEGWIVIYMDDILIFSNDLEEHHVRTRRVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGDLHPCAYISQTLNPAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDVLSRRNGLDDSESDNEDCILLPNALFVRSISLTLFDEIRNHAAKDLIVHEALEAIAHKGPFPMKSSLSDWEVRDGVILYKGKIYVPPSETLHRDLVRLHHDSPAMGHPGKFNTLELLCREFWWPGMYTFVYNYVKGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNSFDSIMVVVDHDLTKGVILMPCLKMITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLRLYCGNNPETWADCLPDLKFCHNTREHSAQKMSPFRIMMGYEPRGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELARQQMANRVRQGSLKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGSANYRLKLPKTWRVHSVFHAALLSPYCENDIHGPNYVNPPPDVVDNEEEYEVKAILNHKMYRGHLRYLVKWKGYSSAENSWEPTHNLQNAKRILDAYKKTRGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBY1</accession>
    <name>A0A401GBY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0208880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610601.1">
        <property type="nucleotide sequence ID" value="XM_027754800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBY1"/>
    <dbReference type="FunCoup" id="A0A401GBY1">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBY1"/>
    <dbReference type="GeneID" id="38776605"/>
    <dbReference type="InParanoid" id="A0A401GBY1"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="8">
        <location>
            <begin position="62"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="324" mass="36148" checksum="F322EAE82DFC81E1" modified="2019-05-08" version="1">MLATRTALRSSSRYSAPTTKIRHECSSRASRTFISAAVQGLSEQFLDLAIALPLPPSLPPYSTTILLVTVVSRLIFTVPFSVWAKNRQWKAENLVAPQLQQEAPQMRQKVIDDMKRGNYRGDSDEAIKKEMQKRARALLKTRRAELNSLHGCSPIPTVVIPPLTQLPLFVGFSMMLSRISHPPTVLDSESFFTLTSLAHSDPTVTLPIVLGLVTLANVESAHWFLSATALERQKKVEQWTADRRAKGEVVVEPRKIVQTALRSLSIARILIAAVVPGTIQLYWVASASFGLVQTWIFDWYDARRARRLTQSRPSGLPKSHSINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC51</accession>
    <name>A0A401GC51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0209500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610662.1">
        <property type="nucleotide sequence ID" value="XM_027754861.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC51"/>
    <dbReference type="GeneID" id="38776666"/>
    <dbReference type="InParanoid" id="A0A401GC51"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="173"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="341"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="972"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1428" mass="159002" checksum="99CB2035DFC58F25" modified="2019-05-08" version="1">MVGFDNIELVMDILSNRPSAVKEVSNYLQGGQVNETSTEVHGRSAPVGLLGVSLDPEDARRRMELKLRANASRPLFTGTMQDAPEVLPHIYTSSSIVQTSSILSQYGSKYMLPLGTTRHDCEDYEEVILPPAKAVPPRATERLIAVSELDPLAKGSFPARVFASVKIVVTSYAPMKALASEIVRKLGKRLQWLSIRVRELTGDMQLTKSEIAETQIIVTTPEKWDVVTRKPTGEGELASKVRLLVIDEVHLLNDERGAVIETIVARTLRQVESSQSVIRIVGLSATLPNFLDVAEFLCVSRQTGLFFFDSSFRPVPLEQHFIGIRGKPGSSRSRKNLDRVTFEKVADLVREGHQVMVFVHARKETVKTALALKEAAMADGILDDFSCEDHPSFSNFRRSISESRNKEMKQLFDNGFGIHHAGMLRSDRNMMERMFEARAIKVLCCTATLAWGVNLPAHAVIIKGTEVYDSTKGSFVDLSVLDVLQVLGRAGRPGMESSGVGFICTTGDKLAHYLDAVTSQNPIESKFTAGMIDALNAEISLGTVANVHDAVQWLGYTYLFVRMRKNPLQYGLSREQVAEDPQLGSKRNQLAIEAANRLAEARMITFDKHTGSFMITDLGRIAAKYYIRHTSVETFNKEFRPKMTEADVLRMLSKSTEFDQIQVREAEVKELKIMMELIPCTVQDGTDTSQGKVNILLQSYISGLRPEDFALVSDQAYAAQNGGRIVRALLEIAISRKWANVSAVLMGMSKAIEKRLWPFDNPLKQFQLKQEVLHNLERWADDYTVAELATMSASDLGELVHLNERHGLAILDAAKQFPTVQIRFSLRPLGFDVLKIAVRVTRLFNWSSRIHGSVEPFWLWVEDSEGLSILQLSHLIFRQSIDTLDVDFVISIPNGHPPPSTTIRFVSDRWMGAEDELSVPFTDLVMPSPSECHTPRLDVPYLSLSVLQNPILEDILAKRLHGFNAIQTQAFWSLVKTRRHALLCAPTGCGKSVLGRITVWATLNQAPNNSWVLVVAPRRSVALELVTDLRLVSKALNIAVEICTHGSLFKQSPADVRVVTAADLLLALSNQPRGKMPLSGLRLVLCENMELLDSAYELGLSLLLRATQAYPVRFVGLSSSLNDPADLAAWLDVDPLALHSFRPSDRDQALTVSSQTFTIPQSAALFKAMAKPAHTAIQERRGESAIVFVPSRGQCRSVALDLITQCALEMETSRGYLPAEVPFEQVEHYTSRLQDRGLVDFISRGVAFFHQDITRADRTAILELYAEGLVRVLVVPHDSCWSLPVRAATVIVMGTQYVHIPPGGEERQVRDYSLEELVRMQGRAVRHNAAGHFHLFCQAETKDTITRFLNEGLPLESKLLETGDLQTWYRDRRKDGSIADKQQGVDVLSTTFLARRLISNPAYYDATSTAINELLSRITDQLDDAVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCY1</accession>
    <name>A0A401GCY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0212120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610923.1">
        <property type="nucleotide sequence ID" value="XM_027755122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCY1"/>
    <dbReference type="FunCoup" id="A0A401GCY1">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCY1"/>
    <dbReference type="GeneID" id="38776927"/>
    <dbReference type="InParanoid" id="A0A401GCY1"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="6">
        <location>
            <begin position="54"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="5">
        <location>
            <begin position="177"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="874" mass="97923" checksum="ED4241F2CB09B0AE" modified="2019-05-08" version="1">MSQARFPPRSLDPSVEDHLRVEAFEGKFDVRDFVGSISERLIAQSKSDPGPFDPKPFIRTFEAAVDKLIAVRKDVQAKTEQMEKIVRTTERDYSKKMAELNRGFESVSQSFSGMETKMTEVGRTAVRIGEQLESVHQQRQRAQAAYDLIDYYHQFSRDDTTRLDALKKEGKDGRRQVAILLRRLGTVAKEVDLPHAEKTRENIEKYCEKFEKDMLHLFDRAYRRGDPKMMHHCAQTLLEFNGGASCVQVYVNQHDFFINRVPGSNNVDDQLWQTLPDPDVSPPATEAGMQELFQEIRDTVGQEAQIVQAVFPNPPFVMQVFLQRVFAQSIQQHMEQLLNRATGLSDLSFLRIMQVVHQQTALLVEDLKAYELTTVAPRTPSDTTDFNVTLNGSASTFGATSVATVSTMLETAMEELFVPYTEGQRYLERESRSLGQLYASYLSNFTRYHERSHKGGGKSSMFDRMVNQLSAAASTTSTTGSATTSAQAAAAIMRIGGLSSNADRSQDKGGEEPLREEDGRISVDIAEKMLKWHAEAIGRCVELSPAGEVPKHAFALLRVLSAAVGGAYMEVAIETIQARLQSADWKTEPSLQLLAVLRELDLICHLWQHYVNMALLPLASSSVTVRRDMVVFNNQSVSRIEGAVNHVIQRLADWILSYLTSQLAKQKRNDFKPRNDDLSFARVNTEPCVACCDTLERVRDAAKSNLSGKNLEVFLTEIGVAFHSLLLDHLKKFPVSATGGLMLAKDLKHYQDTIATFGIPSLHERFEFIRQLGNVFLVRPDILKSYITEGYLGRIDSSLLRPYLAQRSDWGQAEKGFNDADGGELADNKGLRDRFGMGRLSMIMKDLELKDLNVGMPHMPALSTSLGSSFTFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD49</accession>
    <name>A0A401GD49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0213110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611021.1">
        <property type="nucleotide sequence ID" value="XM_027755220.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GD49"/>
    <dbReference type="GeneID" id="38777025"/>
    <dbReference type="InParanoid" id="A0A401GD49"/>
    <dbReference type="OrthoDB" id="2802638at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052130">
        <property type="entry name" value="AEBP2/jing_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46541:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN AEBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="922"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1306" mass="140521" checksum="6C0269F7BA611835" modified="2019-05-08" version="1">MSYGQDGNEPKQLALIPGNVVVTPNDYGQNLDRIRQMKEFVANYEAHNEAGLRKYYSQEQELKRRIEEGREAERLLSRIQGGSQSTPVGVGSSLDTTPGPSYASSPSFGYTNAQSTYQEASRIVELPSSGQQSPDAGRQQSSSTTYQVPSSVPHQQQPYIATGSSVNITQPAYNSWAQQQHVQAQNWSQLGHPKPNNPMDGWGQLPGDSDSVLSGSHSNRHSTSHLQLPRNVGGHSSSTTNRFGSADYPSASHAQSIPPSITSTLDGALGASFTSGPAEGVNHAKVTYSSSSVKAASAQPTPLIGTAATQKDAEICGNIVNVLKNLRPTTIQTIIALVITVLQVKLNVTAAPDHSTVQSQSAAEQEHIQKVSKYVVSQLQGLDRNAIIRILMTVKHNMQSSQLPQTGPQAIPQAPLPPVSRPSQVPTSSQLTHIPTSTSAPHSHPPASSTPPVTAPLAGGGQQSEGQYVTASQIGLSWNKQSKLPPPEHDRRGDSLDRRHLLPRQIYANGIANTSLVQAGTSTASAQPGLQPPVKSVVSQPVAIASGSSVLVNVAPNPSPFIVFPEPQTPPRPAERPHSPWTPAKADKGRLAQDIIRSLGRPTGSPSVPLVRTHSDAHAKAKRKRATDSPETLKKQKTREPMDVDGEIITIGAVESQRKEMQNSNTGAQLEDAGVQQQQQRQGQSAHNLELAKVVVAAVEHTPPESVASQPPSSKTTSPGPSLEKAPLRTPEIPQSGHEPSVQPSLASPAPSFGISHPDAEPALSQPAPKVDVIEIFDSDEDDTSSAIARTGQADSGLSQMPLFLPSPSSSVGAQDDELAGAPEQGTVDADGDFNMGSGSFVLNTSLLGPASSSRPDKGKGRALSIDIDAIDLTPTPPKRLVKRAKPRVSEDVYVLVPPLPTWAKRMNASIEARAPQAAGSETDELAGDDENEEERRREEAMRQDAVRLSYTRLRKAPCRWRNCDALLNSAQRLDKHLAMHVEEQDGKGALVCDWQECARKFTSKTAFLHHISRHASTSLFCAYEGCNRSFTTPRELFGHHNGHMHRWQNIRATPMPFQHVDVNLPPLPETLPAYMSLPRRVTRHPISKELHNWLGPRVLANISFFYCPGLRSHHSTPSRGSRRIAEKLAAVEKESTDPSVILELMRRMTHDEYDLIAQETTQKASKRCDDIPSSEVTRLCDDGLVLWPSADEQREASAEAEAKDEEEDQLPLESGHNSPPEPVDGEGAVRADQAVAAGSAAGVASGVEGPDEVHDGTKDVADDVLMHDASDDPEVHQDGDEQSQPEWTAVQSNGDDEVAVESLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDJ0</accession>
    <name>A0A401GDJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0214550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611157.1">
        <property type="nucleotide sequence ID" value="XM_027755356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDJ0"/>
    <dbReference type="GeneID" id="38777161"/>
    <dbReference type="InParanoid" id="A0A401GDJ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="153" mass="16933" checksum="AD28E600A0C6CFE8" modified="2019-05-08" version="1">MSQCMYFNSCIPLPADLRGGDTDTAVARPAQNAARLRDAVDWEDGRGGPTALSALAAGFCPDLRGSSRTWVVLPGLVWFFPDLRGSARTYTIRQALRIGMRPTACERFAVDRSSSKDHVDRPLQKLRSQRGLRNQMVQKFRWIGATVPPSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDQ9</accession>
    <name>A0A401GDQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0300120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611210.1">
        <property type="nucleotide sequence ID" value="XM_027755409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDQ9"/>
    <dbReference type="GeneID" id="38777214"/>
    <dbReference type="InParanoid" id="A0A401GDQ9"/>
    <dbReference type="OrthoDB" id="2751048at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="452" mass="51625" checksum="A40DA722357AF068" modified="2019-05-08" version="1">MSRATMRDMALLLVTSEADVEGLVLRLSYLARDQCRHRVRKILLLLSFMLIWTGNSRHLQLFLSSQFLPTHTITILPWWLQLWSLWQKAMEKFEVSLQLNTRDLEKAVCPAIVKFPVDISPTAFLLEVCCTMAIDHADHLGWKLNTDRRSDEHIQLESADDVDIAIKHTIERRAKAVSRNIVLEVVNKDYKPGATTMKKADAAPVTKSTELAYREEMQLVKEKLHCARCRNENKWCYVDPTDPKDHVPLDIKHLTLWARIIHDGKAERDCIDPPNCLNLDKLRTHRMHSTRQAKVADGSALPPIHLHLGSLLCDISSNHHAHHKHHHRSPSSLESECSKSESDDKATSVVVPIQDILAELEKMQPAAKYPQFYDAWAAKGVLYSGSALYFDVKWYVREVRMPEGLVRPFLGQVKSMVEPKKSKKHSRHGKKRVHVAANTDADSDDKNCPVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDV3</accession>
    <name>A0A401GDV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0300650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611263.1">
        <property type="nucleotide sequence ID" value="XM_027755462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDV3"/>
    <dbReference type="GeneID" id="38777267"/>
    <dbReference type="InParanoid" id="A0A401GDV3"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="297" mass="32441" checksum="5876C98A514BF6CC" modified="2019-05-08" version="1">MISLVGGHLLSLSFESVALGVHTLTLRHCLRPSRWERSGSPKRKNWTILLVALILYALGVVDVVLNIYYNLDAFVFHSGSGGAEAVFTDISNPVNCMRTTCLMMATLVADGMLVYRCWVIFGQVYYMATLLPGASLVAAPELQVFISAFGALNITLNMGTTVLIVCYIWFVHQQSAQLLQRETSGMIGLKAIMRIFVESALVYTTVVVIAYIADLTGCNIVYAMGDIELEMAGISFDLLIIRCREIACRNAAVDEDILTTLRIQSPKDTTSDHNTGIPVEEAASTVNLSTPSTSMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEP6</accession>
    <name>A0A401GEP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0302880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611486.1">
        <property type="nucleotide sequence ID" value="XM_027755685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEP6"/>
    <dbReference type="STRING" id="139825.A0A401GEP6"/>
    <dbReference type="GeneID" id="38777490"/>
    <dbReference type="InParanoid" id="A0A401GEP6"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="32868" checksum="A5DC1183F7BACD74" modified="2019-05-08" version="1">MVLLKRISTSIHPYEIEIGQFFSSEPLASDARNHCVPIYDVLRLPDDEDIALLVMPLLRGYNDPRIQTIGEAVDFFRQIFEGLQFMHENHVAHRDCMNLNIMMDPKPLYPNMFHPLIHFATRDYIGTAKHYTRTGCPTKYYLIDFGLSRRFHPDGGPPREYPIFGGDKTVPEFHKSDEPCDPFPTDIYYLGNLVREDFLQPFHGVDFMLSLASDMVQDEPESRPTIHQVVSCFEDIHNSLGYLQLRSRLVGVNEPLIVRIFFGIRHFFRTVGYVLTCRSAIPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF00</accession>
    <name>A0A401GF00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0304240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611618.1">
        <property type="nucleotide sequence ID" value="XM_027755817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF00"/>
    <dbReference type="STRING" id="139825.A0A401GF00"/>
    <dbReference type="GeneID" id="38777622"/>
    <dbReference type="InParanoid" id="A0A401GF00"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="296" mass="32501" checksum="E3CB31A3FDA70F09" modified="2019-05-08" version="1">MRTVELAMLGHTPYPPPDPNAIHPQPPHAQPPGTFQTLRLRDEPPPVTQPPAPRSRKRKSPPDANPDQQQQQQQQQQQQQQQQQQQQQQQQQQQPPGPPGLPGPSMAPPPGMHAFHPPPPHLGGPPIPHGYQYPPTDFTSGGIPPSLQPQPPPAPPQQPDQQGGTSVGRTLSQSKRAEQNRKAQRAFRERRDQHVKALESRSQLLDAALASADEANRRWEECRTLVDQLRIENTALRAALNQMQAAAGLNANPPNGVPPPPPIPTSLLPEQPRVDDPKPAEGGEGVLEEENNQKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF93</accession>
    <name>A0A401GF93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rit1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0304920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611686.1">
        <property type="nucleotide sequence ID" value="XM_027755885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF93"/>
    <dbReference type="FunCoup" id="A0A401GF93">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="GeneID" id="38777690"/>
    <dbReference type="InParanoid" id="A0A401GF93"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="385" mass="42464" checksum="7C7A790C43FEBDB9" modified="2019-05-08" version="1">MPVAHGLEYGSHRDIAALAFAYLHKESLDIYNRLHSIEEDVAFVTSVCSSYPHLPVLPNLRCGAWYVDPSTARREPAYFKSTDGHYGNWSFNLRRPNLHLLQVALSEGGLIIVDSTRSGKRIPDALSKTVPIWCTVVNRAIRSLNPMTQKRQWDTALCCPPGVVSSQEMAQIEERIDGWVDSLLASSYVLPDLAFPLKPLWITPSTTVLPQVTSAALRNYLPVICVSASRSMSEGLERRRNGFAYVPGSGDDHELWGVGLTPQLFWQHKTVILKAIRSDLPTLVGSLVKESPSRSRNDCWTLLPTPIFQVGGSILVGAISDLPLALPSHLPESGADIAFVLISGNSTSEPLDDPGFDAPGTVLQLRLSEGKKEQLHFLRNVLPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFB0</accession>
    <name>A0A401GFB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611728.1">
        <property type="nucleotide sequence ID" value="XM_027755927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFB0"/>
    <dbReference type="STRING" id="139825.A0A401GFB0"/>
    <dbReference type="GeneID" id="38777732"/>
    <dbReference type="InParanoid" id="A0A401GFB0"/>
    <dbReference type="OrthoDB" id="2800744at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="172" mass="18533" checksum="30610EB61DB7CB1F" modified="2019-05-08" version="1">MVLERKRSHSQDVPMLPSSSFATATSNSSALPRQAFSARGVVYPPNRSSSPPASAYFPQFSGDHHQDLEPTTAEASAHFAYSTTLRRHHVEGIPTPGTATGFPSLDELRSVAATEGAAGLWHRTVGTISSWFSQGREGYEALPVSKEETKATASSRFAHYTAQVSKLVSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFD4</accession>
    <name>A0A401GFD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0306000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611793.1">
        <property type="nucleotide sequence ID" value="XM_027755992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFD4"/>
    <dbReference type="GeneID" id="38777797"/>
    <dbReference type="InParanoid" id="A0A401GFD4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="146" mass="16104" checksum="666358F10A86180C" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQPPEPAIHLIKMSNLSPMPLTDQIAGVLELMFRRKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELERKWPPPFGESEIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFL1</accession>
    <name>A0A401GFL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0306720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611862.1">
        <property type="nucleotide sequence ID" value="XM_027756061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFL1"/>
    <dbReference type="GeneID" id="38777866"/>
    <dbReference type="InParanoid" id="A0A401GFL1"/>
    <dbReference type="OrthoDB" id="2919381at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="319" mass="35945" checksum="57B469062ABD12ED" modified="2019-05-08" version="1">MNLPRQGASRNDDKGKTVPRPSNTDNDVSLAPHNWPDMFPLPVNTQPWRATEWYNFVPRYVRNSQRLIDAAHGGDDGARTWVTDLIRQMQQDGHLTASHGMMNLLISWMTNPTSSSMFDEWVAWYAQNPSQVHWAVRHLNDNCLEAPLHQDLEAMWLAHCMAPIIPPDVPATAHNMFIEHTAELFSIPGLYAWIIQVGHYPVANNNEPAPFPRSFAQNSSIYDVVRWYAACEFHPMWIGFLEEFHCRHHNYILRRVLEDVTLFEGHFPVDLRDGCTRPPSDPEPPTPGAGNAPAGSSQLGPNPGVTPEAGDPDHDMGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFL6</accession>
    <name>A0A401GFL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0306850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611875.1">
        <property type="nucleotide sequence ID" value="XM_027756074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFL6"/>
    <dbReference type="FunCoup" id="A0A401GFL6">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFL6"/>
    <dbReference type="GeneID" id="38777879"/>
    <dbReference type="InParanoid" id="A0A401GFL6"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="114" mass="13065" checksum="909E75566809E477" modified="2019-05-08" version="1">MPRIPLQLFRVLARPPTLHPVPRVASLISILSSRPLLPQPTPSVLLACAFRNPVSLSLPSAIIQQARHKSRGTEYQPSQRKRKRKHGFLARKRSVNGQKILQRRRVKGRRFLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGT4</accession>
    <name>A0A401GGT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612291.1">
        <property type="nucleotide sequence ID" value="XM_027756490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGT4"/>
    <dbReference type="GeneID" id="38778295"/>
    <dbReference type="InParanoid" id="A0A401GGT4"/>
    <dbReference type="OrthoDB" id="3222238at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="46872" checksum="10A2D4AEC358FBC7" modified="2019-05-08" version="1">MAARRALSSYDILTEIFEYFSLARSAGIWDRLDSTFALVKCARVSKAFSDIALDILWRDLYGLLPLFQLFSSFVKDVGPDEPPDDLEEAEPMDEPEQYSDYLNGTITPEEWTVFEKYARRVQFFVFLSALPYLEELWISCEHIHMKPVTLASLHALFKLKISGIIAQIVSVLEIISCPNIHTLDITNTQVDSSPHDLVQLMELVWSSSGTSLHSIFYSNAGSFIGDESLLDLVRPLLQTPRLQFVDLQFGLGPWGLPDTDVRDIASAWPELRSFCLSADKSSSRPELYPIGRMPSMGSLAIFAQLCPSLVKLALPFIVDSGYSNSDESHWTTSHSLQELDIDYICPPGIRNPSQTAQFLDSIFPNLDIPLSFQQTSLAYLLLEDFECIHPIIYRRHEGWGTVAQLMEELQTARTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGT9</accession>
    <name>A0A401GGT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0311180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612302.1">
        <property type="nucleotide sequence ID" value="XM_027756501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGT9"/>
    <dbReference type="STRING" id="139825.A0A401GGT9"/>
    <dbReference type="GeneID" id="38778306"/>
    <dbReference type="InParanoid" id="A0A401GGT9"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039588">
        <property type="entry name" value="FBXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008:SF4">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="543" mass="59258" checksum="CC9FFD665EDE5C01" modified="2019-05-08" version="1">MSKHSLSPAPLPPSKRQHVQGPSHSNHSSRSNFDALLYDEIVLVIFSYLSWTDLCAIQSTNRNWSRLALDNQLWKALYLGEYGRTRLRGVRGFIGRGDGREVRPLPGRAKSEEVKDWKWMFRISSNWRTGRCSVEALDTDVQHSLSRVSVPPREQTHILLAGNVTIFASSQTSSAPPIVLTAPTHHTHTMHCRSSVQTQITALALDQSPPHSTQHIRLLSFLSTGEFSLFSVDHRTPSHSSRLLTYVPAARSARTSPISQAVYHHPLLVTLSQSFHLSLYDLSSNSVSHMQTLTSFTSYPPSSLVLSTLVSGDYKLVLAYAIPVFPAHWSVGATELIISSTSLTVASTRTARATDVPQGWVDESKLQAMREQWSRKVARVADTQTDGKWVVLAPADPAATASVTTGSSLPASPSTYASSGMHSASSLQLYRLSFPASLSATALPKLTFVRTLHGQIGPVSALALADGRCVSLGVNGSIWVWDLEGGTGAEVFGSAVCTGKAEVSEDRLKRLDARKTVKGTVVFDERRILSADGDGVHVWRFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH89</accession>
    <name>A0A401GH89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612470.1">
        <property type="nucleotide sequence ID" value="XM_027756669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH89"/>
    <dbReference type="GeneID" id="38778474"/>
    <dbReference type="InParanoid" id="A0A401GH89"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11079" checksum="7E1202EC7855F01A" modified="2019-05-08" version="1">MHENGSARKRAPAQKRALRGSPQGIKVGEEKGGDNGTGAEEGDGVDNDNGEEEEADMATEELADIAGMMEIRRQGRRRPNSGQRPDGACGLFVRDKQRLRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHD6</accession>
    <name>A0A401GHD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0313360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612520.1">
        <property type="nucleotide sequence ID" value="XM_027756719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHD6"/>
    <dbReference type="STRING" id="139825.A0A401GHD6"/>
    <dbReference type="GeneID" id="38778524"/>
    <dbReference type="InParanoid" id="A0A401GHD6"/>
    <dbReference type="OrthoDB" id="2757744at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="173"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="410" mass="45503" checksum="D451276A85D81F71" modified="2019-05-08" version="1">MSSVRSQGFIRQIKNLVNSTFPSEELETRARDLINVLKDNVEYDGPPWTRSGNCSIKLSDILEAMIYHAFGCGGEAGRRYTVCAICACHHGGTPNNVEDHILSQLRDLATVWLSHLLFMFKVKGSHTKQQNDTPSVIATPILDDTTTELTQGAPKSRSEKFKLQLLKRDDYRCVVSGAPDISFPDYPEDRVHEVVFTQACHIIQPAIADFDPPESANKKSYLSALTTFDILRNYASVPIANIADFQETIHDPSNGITMNFDAHRGFDNFAWCLKATEVPNKYNVVYYRGPHGLHTRPSEITFSDHSAEIDSTEEKASSLLKRQCTRASASGPRQGISLPNPLYLRIHAAIAGILHMSGVGRFIDEVLRKHHNTSGSEATFTGDDFLDLVTTVNLRESVANMAIREVAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHN4</accession>
    <name>A0A401GHN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0400530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612595.1">
        <property type="nucleotide sequence ID" value="XM_027756794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHN4"/>
    <dbReference type="GeneID" id="38778599"/>
    <dbReference type="InParanoid" id="A0A401GHN4"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="369" mass="41099" checksum="43F0D471B053CED5" modified="2019-05-08" version="1">MPVAPVDDHGTVLYYEDSGTPPASSNYTTIVLLHGACFYGPIFRPLLPFAASNNLRLVLVNLRDYPGSTPFSPAELRAIRENPSDAIQARGFELAAFLSWFVEREKIPPISESSDALHVRIGGLAVLGWSAGNYQTLSILAHAEKLPEVTRTLLNAYLRCVIFYDGSSSCIGEPLSKGMYNPLADPNLSDAQKWERAPTWLSSYYTKLELDLASETSAFTSALIARVPLHEAVVAGSADSRWTPTVQRMSVDELKSVFYGEVLRRSQMPIVNIDARIYKENFDRALFGFPSNSSEVRSAEDLVWPNVSIQVLWCDMSMSSGPYAVHHIVRLRESTKGGRTVGIHRLEDANHFAHWDYPERFVRFLAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI01</accession>
    <name>A0A401GI01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0401750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612715.1">
        <property type="nucleotide sequence ID" value="XM_027756914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI01"/>
    <dbReference type="STRING" id="139825.A0A401GI01"/>
    <dbReference type="GeneID" id="38778719"/>
    <dbReference type="InParanoid" id="A0A401GI01"/>
    <dbReference type="OrthoDB" id="3194788at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37182" checksum="95ED07B148B18CB1" modified="2019-05-08" version="1">MTQREAELELIIALKNLAHLTFFKWRGHPNVVIAKKEPDGEDVWTSLTQCRNLKEIDALESFMDNPPYPIWGGAIFRLSNLTSFEYWTAVDGIAPDLYGIDTLGIMLRENCPKLQKLYVGFSCQGEDTVANVERSIMSGRWPDLHSLHLEWAACSPSAAVSFLAAHPQITDLSIDEFIGSTATAEGLPLDCPPELLPNIKTLECTTSQAADILSSASSQPRPLEHLSLIDLPFSSRQAEFLVVLTPLMSIRTLQFRYTFSTEAIARVAEAAPWLPRLQIGNSSWLLSSCRDPQTKKRWQKLLEPFFHLEALDSAEGDVLDAIRGPLPSTDCGGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI25</accession>
    <name>A0A401GI25_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0401920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612732.1">
        <property type="nucleotide sequence ID" value="XM_027756931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI25"/>
    <dbReference type="STRING" id="139825.A0A401GI25"/>
    <dbReference type="GeneID" id="38778736"/>
    <dbReference type="InParanoid" id="A0A401GI25"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF511">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="190" mass="20099" checksum="654DFDF30BDE83E1" modified="2019-05-08" version="1">MKLISPAPLSFSPSLSSASSWHTAQSAFPGSPTSASGSSTTFAPTEILPRLFISDLGAAESATTLTSLGITHVVSAMCGRVLVPSGMPLKHLQLPIHDNPFAELAQLLPAATSFVSDALRDPNARVLVHCVQGVSRSSSVVCAFLIAHYGWSPDRALQFVRSKWSRADPNPGFVGQLSEYAESLRAPARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI40</accession>
    <name>A0A401GI40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0402480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612787.1">
        <property type="nucleotide sequence ID" value="XM_027756986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI40"/>
    <dbReference type="STRING" id="139825.A0A401GI40"/>
    <dbReference type="GeneID" id="38778791"/>
    <dbReference type="InParanoid" id="A0A401GI40"/>
    <dbReference type="OrthoDB" id="3194788at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="46957" checksum="4E4C483D5E5E91DA" modified="2019-05-08" version="1">MRTTTDLPPEIVEAIAEWIDCSDDTLSFALASKFTASILSPRHTQLRHIRCDVNAMCLWRAFSHDQSLARNVRSLEIMSSSPCRVPRFICTCDRPCAHDVSRREAELELIVAVKNLANLVSFKWRSAANVVIAHMEPDRQDVWTSLACCRNLGNVDIAENNWLNQAPTGSEAAILNLSDLTTLRYTGLFADSRPIDATVLGVMLRERCPRLQKLILSLPCRPPVRSRDAGESILSGRWPDLRTLGLTGAACSPATAITFFVAHPQLSQLSIDELIGCDPQYHGRLLPLDCPPGLLPNLRKLESIAERAIELLSAPSAQPRPIEHVSIWRGPHVEDFPALLAALPSVTSVELQVATVDLVARIAQAAPWLTRLRVPSGTAILSDLHFDKKKKKWQAAISRFRCLEAFESQNPECNMLDVMRSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI64</accession>
    <name>A0A401GI64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0401680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612708.1">
        <property type="nucleotide sequence ID" value="XM_027756907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI64"/>
    <dbReference type="STRING" id="139825.A0A401GI64"/>
    <dbReference type="GeneID" id="38778712"/>
    <dbReference type="InParanoid" id="A0A401GI64"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="557"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE81795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="883" mass="99914" checksum="A85BF5F6930594C1" modified="2019-05-08" version="1">MSGTTESRDSLSSLFRIEQLRDDNWLPWKRRTMAILRERGVLKYVDGTSEKPKPVDATTPTPEEMAATKKWIEGDQKAQTVIELLLSDSQMIHITDATMAVEMWNQLKLVKEASGQLGIMAYRRKFYRTVATEGSNIAAHIRELRQTQEQLHTMGSKVSDDEFRMILITSLPESWDQFTSAYLAATSQKDTLPTSYELIAILLEEYRRRREKGGADESALAARGRWTQPKNTTQGRTDRKSDVECWNCHKCGHTQHECWSKGGGMAGQGLRSKKGGRAQARTNQAQSTNDVLRDVAFRTDEVTCAGQQFSSQFSRYDWLADSGMTSHVTNLRDTMTDYVPLEASSIAGIGDQSAAMPSEERANIACDDSDSWELWHRRYGHLGFTGLEKLYKENLVEGLTIDENSMPLTQCEACIQAKQARRAYPKEAEDRTQMPGELMHSDVWGPARIASIAGSRYYCTRRCQVLFMKHKTLRGKTPEEAWTGKKPNVAHLQEFGSDVWILTEGQNLSKLEPKSKKHTFVGFADGPKAMHYYDVGVHLIRVSRNFVFADVLNPASNVPVHQLDDSDRLPLEGESGGAVKQQPPTSASKPASVPVKADQSNKKHDGNHITEEDLPPEMQESMRERPTFLPAPPKIPLHCTTHAMQDHDYRKMDNPRVQPVKSRELPGVPKENALGESAKVAVMPEEFEEIAQALYATALASGDRTASAGDEPRSLARPKPLRNGQMDVKGAYLNGDLQEEIYMRQPEGFDDGSGHVCRLHKTLYRLKQSGHKWNRKLHRELMELGYKRLEADPCVYLRERKEGEVQIITVWVDDLLLFTNSPKLMEELKRDLQDLFEVTDLGEPQKFVGIEIERDREAGTLQISQQHYIKSILKRYHLENAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJW4</accession>
    <name>A0A401GJW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0408230</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613352.1">
        <property type="nucleotide sequence ID" value="XM_027757551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJW4"/>
    <dbReference type="FunCoup" id="A0A401GJW4">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJW4"/>
    <dbReference type="GeneID" id="38779356"/>
    <dbReference type="InParanoid" id="A0A401GJW4"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="926"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="964"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE82439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="995" mass="108176" checksum="90067DC28210BC1A" modified="2019-05-08" version="1">MDAPWTKTGDEILQHFSVDPSRGLTSDLAAKHAELYGKNELPEDPPTPLWELILEQFKDQLVLILLASAFISFVLALIDNSEGVSFVGAFVEPVVILLILVANATVGVIQETNAEKAIDALKEYSPDEATVYRNGQVCRIHASELVPGDIITISVGDKIPADCRLLSVSSTSFRIDQAILTGESISVNKSPIVVPDLKAVKQDMTNILFAGTTVVNGKGRAIVVFTGQHTAIGDIHKSITSQISEKTPLKRKLDDFGDMLAKVISVICILVWLVNYRHFWDPAHGGALKGAIYYFKIAVALAVAAIPEGLAAVITACLALGTKKMAQKNAIVRNLPSVETLGCTNVICSDKTGTLTTNQMSVSHFFVIDSTGALKEYTVEGTTFAPYGSVESAGGKDASAEPRSEPLQRLAEISAICNDAKIVYHADKDIYANVGEPTEAALKVLAEKLPCPDPEVAKSLPDLAPAVRASVVNEYYERTIPKLMTFEFSRDRKMMSVLASKNGSGVLYAKGAPESILERCNAVLIDNTTVPLNAKLRSTILEQTAVYGSQGLRTLALAYAPQQVLDNACYRTEDPQDYARFEKDLIFVSLVGMLDPPRPEVKLAVANCQAAGIRVICITGDNKRTAETICRQIGVFGEDEDLTGKSYTGRELDELSQEEKLAAVMRASLFSRTEPSHKSQLVDLLQSQGLVVAMTGDGVNDAPALKKADIGVAMGSGTDVAKLAADMVLADSNFATIEQAVEEGRLIYNNTKQFIRYLISSNIGEVVSIFLTVLLGMPEALIPVQLLWVNLVTDSLPATALGFNPADHSIMRVPPRNNREPLVGGWLFTRYMIIGVYVGCATVAGYAWWFMYYAGGPEITFYQLTHFHKCTALFPEIGCEMFTNVMAHRATTMSLSILVTVEMLNAMNSLSENESLLALPVWKNPFLVGAIALSMLLHIAILYIPFFTQLFAITPLNWIEWKAVLYFSAPVIAIDEVLKFISATFIAPPSKIKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJW7</accession>
    <name>A0A401GJW7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0408370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613366.1">
        <property type="nucleotide sequence ID" value="XM_027757565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJW7"/>
    <dbReference type="STRING" id="139825.A0A401GJW7"/>
    <dbReference type="GeneID" id="38779370"/>
    <dbReference type="InParanoid" id="A0A401GJW7"/>
    <dbReference type="OrthoDB" id="549353at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905762">
        <property type="term" value="F:CCR4-NOT complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10910">
        <property type="entry name" value="PIN_limkain_b1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR024768">
        <property type="entry name" value="Marf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379">
        <property type="entry name" value="LIMKAIN B LKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379:SF3">
        <property type="entry name" value="MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="356"/>
            <end position="434"/>
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        <location>
            <begin position="464"/>
            <end position="597"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="479"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="689" mass="72892" checksum="26DC21BF34BB658E" modified="2019-05-08" version="1">MSAAIHEHEHVAIFWDYENCSPPSTAPGYDIMNNIREIAHRFGSVKQFKAYLELSEQSSPKSMNLRSELQSCGVSLTDCPHNGRKEVADKMMMVDMLTYAIDTPAPATLLLITGDRDFVYAVSVLRLRRYRVVLVAPNATHASLKSQASEVLDWDCDILGKAGKDAHSTTDDSGLLIPGPGVDLHRRTQSASVLIGQTSQSGVRNPRRLSFRENLSGATLTSEQESGRTHSTFVDRGTSPRFASRTVDVPRSAPQTPVRSSGCLLIPGSKTVETREIKETILEDTEPIPDLNVHLKNFQERSLDVSSISGSSLSLPSTPSITGQNETPVVLQPLADTPQNVTSVKDAPAFLTSPAAHGNCSSPALATSTPLTLSTTPSPALNQVQEPSREPPAGIELPARSVHEVASTKTVSPNSTRGTSEISPTVLKDDSSSLVGSVSSLPLKPPMLSPGWSIATQPAPVQLTLPSQNTPITQGSNANGAGLPMAPKPIAVPVDPPAPTTTAPRPTSIPAHSQPGAPECSGPSVKVVVGVSPPPQATASCGDSSALPVQSESSSELSTVHVLRSVDKPSISQPGPPNTSDPSVVSPAIPSAAPTPPPVQVLSPVPAHYNVLLVVLERCRMIGNLQPSRHNVAMMLMKEDPDAYKRAGFKKFKQYTTYAQSIGMVTLGGAQASAWMSLSPSWYGKAVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKF4</accession>
    <name>A0A401GKF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0410380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613566.1">
        <property type="nucleotide sequence ID" value="XM_027757765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKF4"/>
    <dbReference type="GeneID" id="38779570"/>
    <dbReference type="InParanoid" id="A0A401GKF4"/>
    <dbReference type="OrthoDB" id="3269308at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="9360" checksum="D626172731FBF8B6" modified="2019-05-08" version="1">MKRFSGKREDWSVQTIGKNDLVLLECNIYRWKVNNEGKAIYTDDWRLCRTAFEILTVNLLNIGPEIETKVRVPEIEEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKI3</accession>
    <name>A0A401GKI3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0410440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027757771.1"/>
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    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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    </dbReference>
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        <property type="entry name" value="CNOT4_RRM"/>
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    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="143"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="620"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="843"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="958"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1093"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="958"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1112"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE82659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1404" mass="152409" checksum="4D4B63E3297D3F26" modified="2019-05-08" version="1">MSSRIHPHSPLPAPAMHTTNVAAQSKSYVLAGVQDAYWSDDEAEDAECPLCLEEMDISDLNFKPCPCGYQICRFCWHHIKENLNGRCPACRREYTDEAVQFKPINKEDHKRLTQQKKQRERERKELDALNRRHLANVRVVQRNVVYVVGLGPRFAKEELIPTLRSNEYFGQYGKISKIIIVKRTPPGGRAPVVGLYITYNRREDAARAISSVDGAQSPGGGSDIMRASYGTTKYCMAFLRGVSCPDHSCMNLHEWGDEKDCFTKEDLTTLKHTMKDTETRSRTTTVRKGDESEGLPRGASWASKGTTALASLTLQNNTNQSTASVRPTRRAGANPRQQRPGSSTVTMPNAEIRAGRDRKGGSIGTKAPSQASSSRPATPASTTQSNRPLTPAVTKIARLKEHVPPHSHPYPHPQPAPRSPTSSVAVESDVGSSGRDVEPTASPVQSLANEVPTVPPGISVVPPRLSIPPGLPPPTRPPTDVPQVALQLSQSSYQMSTQAQALMEDIKARRELPVTAVTQSPFPDFDRMLQTLSGADGEYGGFSFNLDPALAGDVAQDVPLPDLEAESTIQFNGSFFDAFPALRQGGPSTSNPLMPPPGLTYPQLSHRSIYDPFAAARAPALERQSSGSSGYTGSFNPFASESNEEPPSRRFSPLDEERKVSRFGFARGRQGSTSSSLHAPSPLGNADNVSHSSFYNSELSSPASRAPPQWPFQARHQAPEYTHPQSSSAMSSPLVQHAQAQSTFAQQQSRFPPYDNGVSEAQLRDLITSSANMRNGSSDQSAYNYGSSQPFHDPAIMSARLASPTIARSVHDAYSNPPSAVESYSSHHLAYGLPPGLQYPDASANRVGYGTGSGPSTNMEVSQSSSAQVSTSPSLAPSPALSSSDFPALSVVEHSLRREQQSDPAFAGDVSVLDVEAQAKAERKAAKKAAAAERAAERARIAQEKAVAKAAERERIAQEKAAEKERATALKAEKERADKEKAERERAEREKVEREKADKEQAAREAKENADQAAQAKKAATMKEAKIPATAKLSKAVDPSALSAVPSRAATPAEKTPTQADVRNRRVQVAKLSPAAVTLSEPATQVPILSRMPKKSKPIAKPIRIPKEEPIADTTSSLTSAATSDAPQFPDTLTQESSSNNSRAGSLDRTVPNQPTPLETLVAEINVQLPWMEISKHPFFDLQKINPAAKMPLEYGPLVHALSALSVGGGSFANNMPSGSIDNAVSSFQQLLETLTQTISDLLRLLPRKTWDDNSSFDGVLRDMLKGDDFLDDGGDDQDSQGKDDEVAALTLALERRARWMEVQLAKLEELHRDINTAAVRAILSFNDSGWDAHGFLPRVGNSLQRFDLIGLAVSKDGVFRPMTADELEKKMMVAKEAEVFAEAELREAMQRMQDLKPTENGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL43</accession>
    <name>A0A401GL43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0412490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613775.1">
        <property type="nucleotide sequence ID" value="XM_027757974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL43"/>
    <dbReference type="STRING" id="139825.A0A401GL43"/>
    <dbReference type="GeneID" id="38779779"/>
    <dbReference type="InParanoid" id="A0A401GL43"/>
    <dbReference type="OrthoDB" id="3155837at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="344" mass="38093" checksum="0CAD851EEE0463FC" modified="2019-05-08" version="1">MASTGNAAYYLGPKLMGVLVEAILTGMMINQSVTFWDKAERGRFTLQALVGVVTIIALFQTGISFYSIWQACVTNFGDWVATIAFTWCEKSQSLITNSLAVPVQAFLIWRCWMLLSRRWYVLVPLTLMLLASIITSIIVTVQTFSIPDSWWYIPTPAPPEVPISSVFILSLASSAVLDVAVTGILLTYLARAKPTIISSRFRRVMKRLTILVWEAAIPPCVCAIVTVILYSTQASDNYWDLGFQAVLGKLYVVSLFVTLNGRASLHELPDHMSVVTCQCHCHAQSRYHATALFTPSDHIRLDMSHDVPPLTPCDGSPTDVERSSLGELAARERDIEKLEGTPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL49</accession>
    <name>A0A401GL49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0412800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613806.1">
        <property type="nucleotide sequence ID" value="XM_027758005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL49"/>
    <dbReference type="GeneID" id="38779810"/>
    <dbReference type="InParanoid" id="A0A401GL49"/>
    <dbReference type="OrthoDB" id="3170088at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="177" mass="20945" checksum="94D47B8B8935E79C" modified="2019-05-08" version="1">MVLRIAGWVFTHDQVRKWLERGGREYKTLEYYELTGALKEWFEERQIRYMAPIPTDYPHGSKQPIILLTTRFHEDPASTVAHYTRFRERDVDRKVKRQVLEETGLKDDDLRWVTVVDPYFHHDVVYKYPRNYVLWPETGMPPEEDEAENKEGGDKGEEKGDKDDRGKKEEAGDKAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLH1</accession>
    <name>A0A401GLH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0500530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613923.1">
        <property type="nucleotide sequence ID" value="XM_027758122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLH1"/>
    <dbReference type="FunCoup" id="A0A401GLH1">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLH1"/>
    <dbReference type="GeneID" id="38779927"/>
    <dbReference type="InParanoid" id="A0A401GLH1"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="567" mass="61942" checksum="B87F96207D72C5C5" modified="2019-05-08" version="1">MSTTKQYDEKKPDVEAAVRAETHDVYDEGESGVDPVYQAKARILNDAFEEIGMGKYQWYLFVVAGFGWFSDNLWPIVTGLILSPVVNEFNFQGPFLKLGQNIGLLVGAAFWGVASDVWGRRWCFNITLGMTGVFAIAAGGSPNSVALCSLAAVWSVGVGGNLPVDSAVFLEFVPASHQYLLTILSIWWAFGQLIGSLIAWPLIANYSCASAAHCPRSSNQGWRYFLYTMGGLMMLFFFLRFFVFHLYESPKYLMGRGHDAEAVEVVQRIAKYNGRTSSLILEMLTEAGETVKEPGREAEMDTSARAAVIRRMRKFSGSHVKSLFATRKLAYSTSLLIIIWALIGLAFPLYNGFVTYFLASRGADFGDGSVYITYRNQVILSVIGVPGALLAGWMVEIPYLGRKGTLAISTVITGVFLFASTTARTSNALLGWNCGYTFTSNVMYGVLYAVSPELFPTKDRGTGNAIVASANRVFGIMAPIIALYANLATSVPIYVSAALFILAGFIALLLPFEPRGRAAILHGEMSYCFVALLIPAIPGKLGSHLHQTHFQTRFGVQLSPNSAPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLL6</accession>
    <name>A0A401GLL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized pyrophosphatase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613996.1">
        <property type="nucleotide sequence ID" value="XM_027758195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLL6"/>
    <dbReference type="FunCoup" id="A0A401GLL6">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLL6"/>
    <dbReference type="GeneID" id="38780000"/>
    <dbReference type="InParanoid" id="A0A401GLL6"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="533" mass="59922" checksum="3D3767B532706CBB" modified="2019-05-08" version="1">MRGSVSTDLMSPAHPVRRSLTLEELGANVDEERKRLLSDGDRPFDDDDGLGDEDNVPPVSYWARYRRIVLVTTSLLVSLIFAIVFLPTLAGLVYPSPRPSADFNSRRLRSNGTHDFRKTALIVSIDGLRADYLDRGLTPHLLDIAKKGLRAKSMKPIFPTLTFPNHWALMTGLYAESHGIVGNNFWDPETEKEFLYSSIDSAWDSSWWLGQPMWETAEQAGIITANLMWPGPPTTMTGASPTYFVPWKDKVPLQEKLDQIVAWIDLPLDERPQLIMAYEPSLDQAGHLAGPASELVNKVLHNVDVFAKDLHSVLEARNLTDIVDIVFVSDHGMTDTSNPEHIYIDDILGEGFSMIEHEDGWPSMGLRFRPEADDEKYLNILLAAAKASGGKFAVYTHNTMPERYHFAHNYRISPIYVVPRMGYVLTNRIENGTGMSKGNHGYDNSEPSMQAMFVAHGPFSAVVKAVEQSRTKGHILPRFLSRPNKGWHSTADDTFVMDAFENVNIYNLMMKLVGIEEHAAHTNGTKGFWDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLN4</accession>
    <name>A0A401GLN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0501160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613983.1">
        <property type="nucleotide sequence ID" value="XM_027758182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLN4"/>
    <dbReference type="STRING" id="139825.A0A401GLN4"/>
    <dbReference type="GeneID" id="38779987"/>
    <dbReference type="InParanoid" id="A0A401GLN4"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="49216" checksum="9AC525C3A2C8AC91" modified="2019-05-08" version="1">MDSFQSCQSTAHTRTLFDAVAARLPSRLKLASQLTSAYADAPVHSMTVSNVMGGMRGLPCILWEVSGTDKDGITYHGRTLSELQGLLPSWNGSSQVSPEAMLWYLYTASVPTRAELEAFSADLLRRSTLPAEVEEFCDRISSDISSIAQMIMCLSVLAPSSKFTAALAQGVPKMQLWRYALEDALDSTARVPMIAARIYINKYREGKHPDALLDPRVDLAENFTRLIGRVGDADFTELIRLYWGLHMDHGANVSAHTMRLSGSAWSDPYLTLASGLISGTGILHAGAIIQALRYNQGMLSALGTEPSDEAIEEYVTKTIANGCVVPGYGHALLRTADPRLEPIVHFLNCRPPQEDNEGAAMLRLIRLTTAIVPDVLRKHIPRMKSHAPNVDSLSGCLMYAQGLDVDFILLVMACSRGMGFMAQYVWDRALGLPIERPLSITMDQLMAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLU6</accession>
    <name>A0A401GLU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0501890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614055.1">
        <property type="nucleotide sequence ID" value="XM_027758254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLU6"/>
    <dbReference type="GeneID" id="38780059"/>
    <dbReference type="InParanoid" id="A0A401GLU6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="16206" checksum="B8F958C243BD22CC" modified="2019-05-08" version="1">MPLDIDPNYVLQAGRLTAIVAAAPRQDDPRYPDWEARIYLEVSQLEKSFPQPLKSLRMPGIVISALLEFTRAYQQKALARLDHISNDDERIYKRYPLAVREYGECEDLGRQWWTEDPYCKLPPVKSTPAEGWGNVPADDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMV9</accession>
    <name>A0A401GMV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614459.1">
        <property type="nucleotide sequence ID" value="XM_027758658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMV9"/>
    <dbReference type="FunCoup" id="A0A401GMV9">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMV9"/>
    <dbReference type="GeneID" id="38780463"/>
    <dbReference type="InParanoid" id="A0A401GMV9"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="591" mass="67055" checksum="CA4CA749AEA34EDE" modified="2019-05-08" version="1">MQSPGPIFWPAHVDYDGYCYGWCQPLVCIAGVLQATSREHAEILLNDAIQSDEWQIAKEASSPEPAIVGRCYFSQQGKSSPSNPGIDFFGDVNNSDHRVPTPFIYYVRPRREMMRFYSFDSRELDILPSHESTDVSCPTKRPEISVLTHDFTRPAFMSVPALDSRILGQLNVAELLTDILQRSRLVHPASPKPADSRTSRALANSLVSTTSFAHIYGGFLHDSVETLLSIVLWVQRLLKEISVAVEQLDIRTEQGRFVLAQVPTVSRNRNASFVDSISQYVKFYNCIWLVLNDVIVGVAFGSFLCENNLVLSRMLEHGMQYYLVECVQHALVWLNNWPAGLKLNTELSQFYCHSLLGVVSAWSHILQSLTPHLPTLIWMVGAMGCCGMTMVVSLLSDSLSLLTAHLYICYFMSTAIFRQQLSLAGSLWNLFRGKRYNVLRNRLDSWDYDMDQLLLGTILFTLVAFLYPTIFTYYALFATTRLAVIMIHATLDTVSALLNHFPLFALMLRYKDPMRIPGRITIAHSPSQLDKFVLENQAAPLSSIFVHYAHLGSRLYSYYHPLRLMRLLITGRRITPIPRSLIRFSMIATRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN41</accession>
    <name>A0A401GN41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0507020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614560.1">
        <property type="nucleotide sequence ID" value="XM_027758759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN41"/>
    <dbReference type="FunCoup" id="A0A401GN41">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GN41"/>
    <dbReference type="GeneID" id="38780564"/>
    <dbReference type="InParanoid" id="A0A401GN41"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="194" mass="21672" checksum="7E915446B80217A6" modified="2019-05-08" version="1">MDISFALTGKGYVIVAADMTAARSIIKMKSDEDKIKVLGPNLLMAYSGEPGDTVQFAEYVERNIRLYQIRNDYALRPPSAASWIRRALADSARSRRPYAVNLLLGGYDTSTHSPHLYWVDYLGTQASVPFAAHGYGSYFALSLLDRYHNPEATLEEGLAVLRRCIDEVAKRLIVAPGRYKVKVVDKDGVREVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNC8</accession>
    <name>A0A401GNC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0507240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614582.1">
        <property type="nucleotide sequence ID" value="XM_027758781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNC8"/>
    <dbReference type="FunCoup" id="A0A401GNC8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNC8"/>
    <dbReference type="GeneID" id="38780586"/>
    <dbReference type="InParanoid" id="A0A401GNC8"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="276" mass="30427" checksum="4AA71A5300D61FB3" modified="2019-05-08" version="1">MANTVLITGASSGIGLASAKLFFEKGWNIVATMRAPEKDTELKQLDPARMLVLRLDVQDLASIAPAVDAALAKFGTIDVLLNNAGYGQFGVFEMTSREKVQEQFDVNIFGLMDVTRAVLPHFRKNKKGGIINVSSGAGHFALPMTTMYCASKFALEGFTEALAFELASQNVFVKSIVPHGGVTSTNFSERLMASAANDPRFDQDYDAFVQKTVEYLKKMGTAQTMDSIDVAQVIFEAATDGSDRLRYMVGDDKRGFIKARYPKDDQEYVAFMREFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNY4</accession>
    <name>A0A401GNY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0509370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614793.1">
        <property type="nucleotide sequence ID" value="XM_027758992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNY4"/>
    <dbReference type="GeneID" id="38780797"/>
    <dbReference type="InParanoid" id="A0A401GNY4"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024621">
        <property type="entry name" value="Mba1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07961">
        <property type="entry name" value="MBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35493" checksum="8E0DF3A2BF8C9552" modified="2019-05-08" version="1">MSRLPRQCLNLATRVSRISEHRHCPCPPQCVIGLRRSYASISKPDSKPREDSKDPKEKSLEFMELLQYSRGTMRYDPSLVPVETMDLHIPSYKSYKKDATWRDHISAILRTQRNAFINIITMYRIAKDDGFPGLHIKNIWSPEVFRAQSTSDSTWLAPFRKIALDTYKRLNEAVASRDEKTIKHLTAGEEQVHYLKLARAQDLSRVYEWKLIGERSPSRVLSIRAVVGNMDRGVEGSRLLVQALVKFDTLQSLEVYSKRGTLLHQQNEPKPVVEYLALQKRLWFNGPWVVRDRVYEGVDSQYEPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQF9</accession>
    <name>A0A401GQF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0604210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615355.1">
        <property type="nucleotide sequence ID" value="XM_027759554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQF9"/>
    <dbReference type="STRING" id="139825.A0A401GQF9"/>
    <dbReference type="GeneID" id="38781359"/>
    <dbReference type="InParanoid" id="A0A401GQF9"/>
    <dbReference type="OrthoDB" id="2803008at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1048" mass="115744" checksum="10D73A834B6F7C2C" modified="2019-05-08" version="1">MNHAPRIEDTDLIDPVLLLNGNAVQVPSQAGPVRTVQSRRSGGSRGGAQEHLAKSSVYWPLKVLRLKEKLREWSLPVSGNKSILVARLDEDDRQRAPYSDTPDAEVLGMGGHTGTGIDDDRVTRDLGALCDSFGCGLVGEEESEDEDQGECEEDKDEEVAPTGMQDQMDVDHPVHCAGSAADSKAWSGHQTESSVLGLWKCWVDQALAAGTISDVVIDSHHLIEYLKYAAMRKLLTTRGLERLGDQRLSASSLKKIMMMLGCVQRQQVDNDPQLDQTRPAMTSRTIDYYRALMVTAQRLRLECSPFEEIKKSILTGLDQLPSVIKAHFSWTWQCTTLNRGDELLNLLLCCIQPHQIFISNYTTVDGRRSGHGRYVFGVLSLYHETKVAKPGQQEPDYNFVLPHRDPLRCSVGALSLLLHFIFNREKLVDSIEGWDWSLAASWRKVKLVYGWKVHKPCSQDAMQKMYKTFLEPTSIKSSKKLHLARRTLPGVMEDMGVNMDEIDGVGHWTGNTRCEVYASKIPKLAMTALAGFYVSEQYDVPWASVKVLQGLQMQLFPFVEEALIHLKAREKINHGTVNFLELLQQLRPFLWRIMGAIHEAFPESALFKRLEVLQSDEARLFLTHWPAAHQVKDVEAQCATQAAAVFAESVTQSTFMALSMGSQNVEASLREQSQQLSVISRCTEQFSPSKQAPARCTRNHELTPTPSVHVANTPQGATSELLLSMPAQGVAMMRAEIGGAGDDPFSDANSMRVPIAATHPGTTAGVPMDIDHTVNIPMSASAAVRCDGRQPNTLLHGGTRVPDGPASLIPYSVPHNVFDPILPEAAAFHGENKPPPHTYPLFTSSSCSWTAILPLIQRPDLIWKCWKPGTLSDYRTIRDLWEVWMEGERIDGVGRKPPLREVDKLWGMQKNKVTNKGRQQSWRPRNDAAARQHWTQFMYFVSRVEGLMDQGKTLSEAVHQLEQQRGTLSLHQLRKQTQSKRKSVQTGPSLVDPPPVGGTQPAPATTANVATTANVAISANAAIVGSGGNSAVTPSSGSAAHSADSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQS0</accession>
    <name>A0A401GQS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0604880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615422.1">
        <property type="nucleotide sequence ID" value="XM_027759621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQS0"/>
    <dbReference type="GeneID" id="38781426"/>
    <dbReference type="InParanoid" id="A0A401GQS0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="682" mass="74955" checksum="B7CE50E14706D1AA" modified="2019-05-08" version="1">MPPRTNSTPTKNCGRTAGRKSIKSDKMVADSDVEMDETSPSKQKITAVKSTPKAVVPMPRNVKAKNMMDYSDEDTVTREKAITIPHKGGKNNQTIDNSDEDMAVNSSHKAGKYQKVVESSNDDKTNLASCMSGRTAAKIASAKLKDVFMDNDSDVEQSLESDAALPINEPEITETPKKKANKAFVLLPTPISPSPNKGKATHTPTKRVYVSDSDKDAQPEQSSPIKKGRNRQSRPDSEAEASTKQSKLNPYDVMTLLRLAMTKMSEQERQDFCLQVRQYDPRDCDIRLSPTKSASGSKGKTEDVLIHQPSRSDVQKLLPSKAIVKDGKMEINNEDTDEGEENFECQVTSITLMDPILLKAGAYETLPPFRRAYYVITYQPINTLTSTGVLDGFMGYQVNKPALIKALTFAFSDGLFVNPARANIKNYQMTGSLESRLGARQLAITFGAVTFSAVAASCMIHSMSKWTKDINIVPMSLEWEWTVAFFGSFIGDNYGLYTYQNSVTMSTRPSTLEHPDYAGNSGSTSLNKMLSKASPSKAVAGRHGGPSTSADGKHAAGFILPQGKVPSTLDHWDDVVVYDCTVFFQGIESRKRDNEFSFNSVRDTCPRWNNEVPLGSFVAVLYSPSQYKTKLGTDSVSLNLMAVCILLKENKLHGAVFSNTWSLQLSDACILNIMSVLCIIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS06</accession>
    <name>A0A401GS06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0701930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615920.1">
        <property type="nucleotide sequence ID" value="XM_027760119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS06"/>
    <dbReference type="GeneID" id="38781924"/>
    <dbReference type="InParanoid" id="A0A401GS06"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="534" mass="60248" checksum="94C6D877E9AB2241" modified="2019-05-08" version="1">MEQREEGKRQSSLPISLIPHLYTGPQQRRNPSGEAAQLETTSEGGERTGRESPYASHPVPSYPVSHAGTLTLTPAAFEDDSERGSRCRSRSPEIQDVHRTRSPRQTEASFLTHPARPFRANTISSDLAYYSHTPYSVPAPSLREATWGQGEAGPSTYHTRQESREEAFQREARRLQYSSQYASQYAGPEHLPPPPRHLPGNLALQEESGHSHNYDDRRVFDPAYAARFGGGSTGTLEHSHPVTREAVAYQDRITAQTRHILNYPGLQTSGSERPRVPEHSYEHLHTYGPGAQFETHGMYSDNTFFQSVPIASPVPRQRILPDIQLQPNIESGLPLTPFYSDTSPLPLWSTTYEDDDHGTEASTSREKTRDDTSRERQTGSRRKKREREKTPSPEAPEASRAPEERPRKIPKKTEGHRILPHSLWKDSQRQAKAKASNKTNGRLQDKVKAKASDDTNTRHQIHLGASKETMKMDLHDRKILSKVLQCIVIARFDQIDIEGGFSNKMHVRQYPAANVGCQCAQHSHPHLRSRLLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT45</accession>
    <name>A0A401GT45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616252.1">
        <property type="nucleotide sequence ID" value="XM_027760451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT45"/>
    <dbReference type="GeneID" id="38782256"/>
    <dbReference type="InParanoid" id="A0A401GT45"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10114" checksum="D8A427F8603D2247" modified="2019-05-08" version="1">MCMTSPIENVYADLFNGSLKSVVRAELYKLNVCGPGSLFKSHVDMPRREKMFGSLVVAFPTPHEGRALVLRHEGQSWTFDPGEIFPKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTU2</accession>
    <name>A0A401GTU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homocysteine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0801450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616539.1">
        <property type="nucleotide sequence ID" value="XM_027760738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTU2"/>
    <dbReference type="FunCoup" id="A0A401GTU2">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTU2"/>
    <dbReference type="GeneID" id="38782543"/>
    <dbReference type="InParanoid" id="A0A401GTU2"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE85626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="435" mass="46650" checksum="485C82E5FE25CA51" modified="2019-05-08" version="1">MASQFYKEPEFETLQLHAGQEPDPTTNARAPPIYATTSFVFNNSQHGADLFGLRALGNIYSRIGNPTLEVFEKRMAALEGGVAAVAASSGQAAQFMAIATIAGAGDNIVSTSYLYGGTYNQFKVFLKKFNIGVKFVEGDAPADFAKAIDEHTKAIYVESIGNPKYNVAPLPELAEVAHAHGIPLVVDNTFGMGGYLVRPIEHGADIVVHSATKWIGGHGTTIAGVVVDSGKFDWARSGKFPSFTEPSEGYHGLKFTESFGPLAFAIKCRVEVLRDLGSTLNPFAAFLLLQGLETLSLRGQRHSENALLLAEWLEQHPKVAWVSYLGLESHPSHKIAKRLLRPNTYGGVLSFGVKGDAKVGSTVVDNLKLASNLANVGDAKTLVIHPASTTHQQLTNEEQLASGVTPDLIRVSVGIENISDIIADFSEALKHAPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUD0</accession>
    <name>A0A401GUD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0803440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616735.1">
        <property type="nucleotide sequence ID" value="XM_027760934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUD0"/>
    <dbReference type="FunCoup" id="A0A401GUD0">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUD0"/>
    <dbReference type="GeneID" id="38782739"/>
    <dbReference type="InParanoid" id="A0A401GUD0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="309" mass="34256" checksum="C9835523D56BCDD6" modified="2019-05-08" version="1">MSSIWTKFFPPKATWGVDQIPDLAGKVIIVTGGNTGIGKDTVRELLLHNAKVYIAGRSQERVEAAIEELKTETGKEALFLHMDLANLTSIKLAVEEFRNKETQLHVLFNSAGVMTPPIDELTYDGYDLQFGTNVLGHFYLTKLLLPLLIATAKTSPDGKARVINTSSMSHEHASGIDYDSLRIGSRRKELGTYRLYCQSKFGNVVFSNELNRRYASQGIVSISLHPGIIKTELARHSWLPMNQLMFMFAYPSSTGALTQLYAGTSPEGADLGGKYLMPWARVVSPRTETDDPSVGSKLWTWLDQQVDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUF2</accession>
    <name>A0A401GUF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0803640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616755.1">
        <property type="nucleotide sequence ID" value="XM_027760954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUF2"/>
    <dbReference type="GeneID" id="38782759"/>
    <dbReference type="InParanoid" id="A0A401GUF2"/>
    <dbReference type="OrthoDB" id="2757639at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="39638" checksum="1896FABDDA2BA4A5" modified="2019-05-08" version="1">MYVVNTETAASWVWALAEHLSKADDSLESIDSAIRESHQQLNGDTLDKVVDIHAHIDKLLSTQVYESIFKLPCLALRLYNAQIIWQRDLQKEVSLRDQQIYEEIQALDPELELGPGKVLSLGKDTFPLRYIRMLVAWHTAVHFFTSHNVLLTGRPLQFALIRIPHPDGDMESVEDVINDEFLASVMQRFFPPGVHVSDIATETILKNLRYAIPQIKSFRGSVHCEAILMAIKAMSNSGIASSGIDMSAKMAIFQDIDNVIGVAKKCCWCCNWLGENLPVPMQECFILPGSHGMIFPWSPPRFGIPLATLASLERELMHKLQLVFMKLGVIVIEDILLQVRQSSREPEVGHCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUI5</accession>
    <name>A0A401GUI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0804190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616808.1">
        <property type="nucleotide sequence ID" value="XM_027761007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUI5"/>
    <dbReference type="GeneID" id="38782812"/>
    <dbReference type="InParanoid" id="A0A401GUI5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7513" checksum="635BDB967D12EA8D" modified="2019-05-08" version="1">MSPSIALIRLSSMTACQNMCGEAPPQVLPLTFSLEDLFQALTLITGCDFDEAWHMVIQQLIANEAAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUU3</accession>
    <name>A0A401GUU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Docosahexaenoic acid omega-hydroxylase CYP4F3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0804830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616872.1">
        <property type="nucleotide sequence ID" value="XM_027761071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUU3"/>
    <dbReference type="STRING" id="139825.A0A401GUU3"/>
    <dbReference type="GeneID" id="38782876"/>
    <dbReference type="InParanoid" id="A0A401GUU3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="521" mass="58512" checksum="F7CC058200A572DF" modified="2019-05-08" version="1">MKSPLDNLPGPPPQSSWTGNLARYMARDGWDFQLDLSQNYGPVVNMTGFMGNPMLYVYDPKALQSIILQDQDIYEESPTFIHANQMCFGPSLVATVGDVHRKQRKLLNPAFSIAHMRRVLPIFYKVVDRLHTAINARVNEEATEVDMLAWMGRTALELIGQGGLGYSFDPLVEDATDEYADALKAFLTTSYSFGLIRFAAPYISQFGTPAFRRHLLKFIPSRRVHKMVDIVDTMYRKSTEIFNAKKAALQRGDETAILQQIGEGRDIMSILLKANMEAKSEEDRLPEEHLLAQMSTFTFAATDTTSYTLARIFELLAEHPDVQERLRNEIVREYNGAELSYDQLMQLPYLDAVCRETLRVYPPATLLHRQVRNDVILPLSAPIRGRDGKMISEIPIPNGTKLFIGIAGSNLNKALWGEDALEWKPERWLSPLPSALTDARIPGVYSNLMSFLGGGRACIGFKFSELEMKVVLAVLLPNFTFESTGKPIVWNIAGVQYPTVGNESTRAEMPLKVGLYKNSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV36</accession>
    <name>A0A401GV36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PinX1-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0805740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616963.1">
        <property type="nucleotide sequence ID" value="XM_027761162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV36"/>
    <dbReference type="STRING" id="139825.A0A401GV36"/>
    <dbReference type="GeneID" id="38782967"/>
    <dbReference type="InParanoid" id="A0A401GV36"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="8">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="548" mass="59481" checksum="5F86736732F0B46D" modified="2019-05-08" version="1">MGLSGRKNKQRIPADPRNLSWANDANKFGTSYLQKFGWDPSSGLGASGEGRTRHISVHQKLDMLGIGADHRNSQDGTAWKQGRDFENLLRRLNEAAGKEVDAGEVEAEAMKVDGFVRPASSEETVIRVEEEVDMDIEVAEKKEKKRRKKREREQAEDEEVAGRDGAMERKKLRKSKSSENRSDKEGKRKEKDKKKRKCDIQVDESPGSAKKEEEASTSVVSTSTSVIITEKSKVAVMARPYVSLSSFHPLVHIATAVLTAISSPARSFATTYLFVLRIRAHRARHIAAKGLASKSAAAINEILGISSSSTAFSTPFLTPSAPATPYPPASLTPSTPSTPLDAPAVDLKLQDLTTSSKSVMDYFREKLAAKSRPLSSSGTSVAGLGTPVTAGAMNDYDDRPKGGLGASRLRFETQVPAEEINTVPLEQDNHPQAGAVEGGRQENTAELPKKKGKKDKRKDGGDDETRDSETDTMQNLGSGVAATERKKSKKPKKAKEIRLAVADGTLPGKPIEAGALRKETVVDLPVDGEKTKKSKKKRGKGKQKDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWH8</accession>
    <name>A0A401GWH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0904570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617491.1">
        <property type="nucleotide sequence ID" value="XM_027761690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWH8"/>
    <dbReference type="FunCoup" id="A0A401GWH8">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWH8"/>
    <dbReference type="GeneID" id="38783495"/>
    <dbReference type="InParanoid" id="A0A401GWH8"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="154" mass="17517" checksum="4C07E2353132C7E1" modified="2019-05-08" version="1">MADSSVTDPQVAADLKKKRTFRTFSYRGVELDKLLDLSNEEFVELVHARARRRFQRGLKRKPMGLIKKLRKAKKEALPNEKPAVVKTHLRNMIVVPEMIGSVVGIYNGKVFNSVEIRPEMTGHYLAEFSCSYRPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWR9</accession>
    <name>A0A401GWR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PQ-loop repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0905020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617536.1">
        <property type="nucleotide sequence ID" value="XM_027761735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWR9"/>
    <dbReference type="GeneID" id="38783540"/>
    <dbReference type="InParanoid" id="A0A401GWR9"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="56" mass="6251" checksum="A5E43AEB1D112E54" modified="2019-05-08" version="1">MPVNTVAENVLGTIGAICWTVQLVPQIWKSWRTKSTEGLSDWFILMWSIGAVFLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWS4</accession>
    <name>A0A401GWS4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0905510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617584.1">
        <property type="nucleotide sequence ID" value="XM_027761783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWS4"/>
    <dbReference type="FunCoup" id="A0A401GWS4">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWS4"/>
    <dbReference type="GeneID" id="38783588"/>
    <dbReference type="InParanoid" id="A0A401GWS4"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="5">
        <location>
            <begin position="252"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="333" mass="36109" checksum="A2149B23C5693B38" modified="2019-05-08" version="1">MGFNPSRVEWAWKATGGRGLQPAMDHILENEGKPVPDLTSVSTSAAPSGAEPMDDEDEDEEALRAVYGKAGIAGAAAASADAEAKSIKCAVCGKVFKNTALANYHAEKSGHDQFEESTEEVKPLTEEEKKQKLAELREKMAEKRAVKAKEEAQENLANEAIRRKSGKDINELREEIKHKELIKEAESKRREKLEDAKARAAIKAQIEADKKARAEKSAREKALREGKPVTGPSEHSAAPAASSSTAPKTSGRDYPETRLQIRLASGGQPYTTTLSSDATLREVAEFLAGQTLSVDVDTVTLAQHFPRKTFARSDFSRTLRDLGLTPSAVLIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX02</accession>
    <name>A0A401GX02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0905930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617626.1">
        <property type="nucleotide sequence ID" value="XM_027761825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX02"/>
    <dbReference type="GeneID" id="38783630"/>
    <dbReference type="InParanoid" id="A0A401GX02"/>
    <dbReference type="OrthoDB" id="2767912at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="35359" checksum="8A0B11E06A754BBD" modified="2019-05-08" version="1">MNTATTHTNTSSSVRIYMLWMDATVDSAQWKLDALQTLHARLVAHCALVSSLAAPIRLISEDLLLRILTYAWPCTMKDRPQFTLSVASVCRSWREVVIEASELWSTIPISIIHPCLPNLRLFIERSRLHGLEINLHSLRYKDYSESGNLSSREEQEHKNVVVVLKLLVPHLNHWKSLSICLPINYITQVLASMEGPADLLDELYVFPKGSMYGFLKSSVFPAHFKARRLTILDLHGIQFPETVVFQDALPALRTLKLSYAKMPGRRSMLQMLEPSCHLEHLELVTPQFVARLGVDYFPRVALVKLKSLSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXE4</accession>
    <name>A0A401GXE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0903230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617357.1">
        <property type="nucleotide sequence ID" value="XM_027761556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXE4"/>
    <dbReference type="STRING" id="139825.A0A401GXE4"/>
    <dbReference type="GeneID" id="38783361"/>
    <dbReference type="InParanoid" id="A0A401GXE4"/>
    <dbReference type="OrthoDB" id="2802867at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="113" mass="12591" checksum="06BAB7C95CEF7D12" modified="2019-05-08" version="1">MKPIKYLLGSAADIGLLALPSPPGPKEWPVIGNALDMPISHHWLTFGRWADTYRDLVSVTPFGQTIVIINSYTLITEMLEKKSAIYSDCRQLFVSGKLITPLHVEAPTRGRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXT5</accession>
    <name>A0A401GXT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1002570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617924.1">
        <property type="nucleotide sequence ID" value="XM_027762123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXT5"/>
    <dbReference type="STRING" id="139825.A0A401GXT5"/>
    <dbReference type="GeneID" id="38783928"/>
    <dbReference type="InParanoid" id="A0A401GXT5"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000636">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="89"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="12">
        <location>
            <begin position="1132"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="516"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="778"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="873"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="654"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE87011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1186" mass="128798" checksum="2DE38A23B989B1CF" modified="2019-05-08" version="1">MDPFSSSLQVPDSSLPGPSRQQARPVSVQPTTSTASPQSSTRKRASHTVVTNQPQQDEQPLYRDIYSHPAALEYAAAHPRRTIPKFGPYLLLQTLGEGEFGKVKLGLHMQWGEEVAVKLIRRGNIDTSVRMSKVEREIEVLRTLKHPNIVRLYDVIETDKYIGIILEYASGGELFDHILAHRYLREKDACKLFSQLISGVWYIHQKKIVHRDLKLENLLLDRNRNVIITDFGFANRFEHRADDLMQTSCGSPCYAAPELVISDGLYVGSAVDIWSCGVILYAMLAGYLPFDDDPANPDGDNINLLYKYIVNTPLSFPDYVSTEARDLLSMMLVPDPSRRADLLAIMAHPWLVPYAHTFSKSVGDLERIAIEQHHQKRLAYQRQMKQTTADSSVSKMSRSHSSRPDGYTTSTATPSSATRSHSHREHRHIQPQQPEYLYETSVDQSMYSTASQNNSRRAFNSAIVLPTTSSVAVDEDPFAPTPSRETPSSSIPMVASPVSDTNLLNGVDEKIASVNDRRNGLTPTPTLAPVKTGSPETKRPKGGFRHTIQVEYGESDGKQEHNKGSVRSTNGVVSIGSSSPEQGRERTSKRPSVDVVRGVEKLLPQTPPSAAHERAGAFAKAATTPPSVAPPVSIEVTGPPVTPVTSAEEKAHRGQGSSGSTSSKQSRHRKGLSIDKIGISKLFGSGSEHINGTMARRPSQSQNSSPGRAPSTDVITGVSKSDMGKRPSTLQVPLSPPTATAHESNAESSILSPDASMISKKSRRNTLTVMVEPFSRSIKQRTKSRATPTETVAKYRPVPPEKDNAPAPFVAPQMVPMIIPAAEMISPATPRFTNASRTGVDLGVPPSTVKGPRLAVPASTVKASRVMQWFRSKSKGRGAADEEVNEKMPYEAESARKAPTSLSSSTNGSTGGLLLSPSDQRSPLPTSQSQRSASSNTEASVGGTTTFADRVRRTVVGGSAANGTKGAIRVHHGAVDQETITTGLPPEVMKHMRKVLQEMGMDVEMESEYKYRCVRPKRKRLANGVGLGLRDTGSGLAAFAMVGTAASSGIDKRGLPLPSQSHSSFGSTGGMLRGLLMRRQSSQVSTTSLNHAPTSQSLDEVSPDAIIAAVPGGSGADVASPVPFETVYGDSQQDQGDEVRFSVELTRLDRLDGTYSLDIRRLKGNLRSYKFLYDTLKQRANLQRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYU0</accession>
    <name>A0A401GYU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1005700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618235.1">
        <property type="nucleotide sequence ID" value="XM_027762434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYU0"/>
    <dbReference type="STRING" id="139825.A0A401GYU0"/>
    <dbReference type="GeneID" id="38784239"/>
    <dbReference type="InParanoid" id="A0A401GYU0"/>
    <dbReference type="OrthoDB" id="2803695at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="394"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="823"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1154"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1197"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1268"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1277" mass="142616" checksum="E5599476E92E5793" modified="2019-05-08" version="1">MPTVTLPGALLDLHAAEKDLWSWPTWATLVCTDHPPWSPEAEENPPEGWDANMVLAVRAFVEKYFNTKAKNKFDFMKRQTDEYSKGRNAWIQWVADTYRTCKVNARVDEVLIEANRDPLTVMRAMKTSTLPSATDAVLWAFYEVTIYRVLGPEGLYENRMPKKGPNEFISVLLIHCWERWRKVVKRDQTAMKKKRAEVDRLWKEMSEKTPTKKDLRLFLGHIKTLMAKLERYGGDEALVAELAARKATLQAMQEALKKERGDKTRARTLPRAMLKALDSLSTAAEILVMQNELKEVLAACGPNDDEEGVAPEVPDGPDVEVEWEDGVEEFKTMTREELLEALGIPKEGIPGFSKKQSKEGLVDPWSEEFDKLAPEDLEDLEPRWHQLVGMLKMMLKMINGEPVLLMDSVGVGKTMQAVGVIALRQWYREYYTQHGRFPGLAGKRQMRSNEQLDGNFDARPSLIAVPANLIPQWEAEIKRYLLKRDFDVVLYLNKLKSRENWWQEVYAKSLHDPSHRIVLASVTALQDDARATLTINTPRWDVPVQHFRFATHGALTLFATKWGVFILDEGHEIRTLNWTYIAARFLMEISAMGIVLTATPVMTRPTDLWNMGRLLKLLAFAIENDDNALLMEREIRAAARRDRKVLKASGEDTHILNIVHGKGKAAATINESEEREKIVQWIEVIRHGFQGAVIRRTQASVDNEGQPISGLPPYIHLPLVVDLHQYELDNLDDIAKQMIEDGVVAKQAKYTSGKSFYLNIRRALTHPGCNHEFEYELPNTLEDWRNKPSKKLETLVEVLQHHLETDGAAPLAVTGPGLGNHPDHVEFHPVAGSPDKIVVYINFPSHLPLIGAVLDLYGIKYVTYDGDTTLAQRQVSLKEFKAADRDGPRVMIMSGVGLAGMNIACANHLIVVDTLWSAQEDEQLIGRVHRPPQAKPVLIYRIIAAKTPDVFLNNIAFNKAVMHQGFTGASTAIKKVFAVGSDDDAGSGDDDSDEDTEDPSEPDEDGSSKAPKPKPKAPKPKPKAQPKPRAPPKTKVPKPKPSQKQADVSDADVEVLEGPPQGKRKPRKKAQAAKSSAVVPSSSEEEDDEPTPGASGAAPVPSKTPKVTYQNRRKAAQPTATEEVVHAGTKRKDRKSMEEEVPKPAAKRSAQPEEASTTEAPMNVDNTLIAPSPPPPTSPSLNSLELGHNVNLPETPDLSQRDSIQPPSELSSLADEDSIKEFDEPPAPAPEPPRRVTRGSTRRTAAEVVKQARKNEQPTTFDQLPKDKRGKPRKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYX1</accession>
    <name>A0A401GYX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1100290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618267.1">
        <property type="nucleotide sequence ID" value="XM_027762466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYX1"/>
    <dbReference type="GeneID" id="38784271"/>
    <dbReference type="InParanoid" id="A0A401GYX1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="81" mass="9135" checksum="945F584AAFC27D49" modified="2019-05-08" version="1">MDEGFESMRVKPYWVGEGSWSFIRSLRADGRLGTIQHTTAEGHLHSEASMGRRCCESDLRAIHEIVARCGKLEKVSVEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZF0</accession>
    <name>A0A401GZF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1101960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618432.1">
        <property type="nucleotide sequence ID" value="XM_027762631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZF0"/>
    <dbReference type="STRING" id="139825.A0A401GZF0"/>
    <dbReference type="GeneID" id="38784436"/>
    <dbReference type="InParanoid" id="A0A401GZF0"/>
    <dbReference type="OrthoDB" id="3025930at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF550">
        <property type="entry name" value="MYOSIN-IIIB ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="165" mass="18559" checksum="F226DEFF5A50EDBE" modified="2019-05-08" version="1">MGFPVDTTVCKGLSHLKVALKNVGFSKRHVAQKCQLVAAILHLGNLEFHTDRSRNEDAAVVGNTDVLDIVADFLDVQPEALEAALSYRMKMGKKELCTIFLDPDGASDNRDELVKPLYSLLFAWLNKHINQRLCHDDFNMFIGLFDLPGPQNMTSRPRSVLHQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZH7</accession>
    <name>A0A401GZH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1102270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618463.1">
        <property type="nucleotide sequence ID" value="XM_027762662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZH7"/>
    <dbReference type="STRING" id="139825.A0A401GZH7"/>
    <dbReference type="GeneID" id="38784467"/>
    <dbReference type="InParanoid" id="A0A401GZH7"/>
    <dbReference type="OrthoDB" id="2569483at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11180" checksum="5E2F2DEF9D3C8B27" modified="2019-05-08" version="1">MQDLVWKKKASKSADRLCCGVPTDFSTFLNLTRSQQFDEQPDYADLCHLLREIFISRGYQHDFIFDWCIPTEKSALSATGNMATQNGKCASLVVGWLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZI0</accession>
    <name>A0A401GZI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1102260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618462.1">
        <property type="nucleotide sequence ID" value="XM_027762661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZI0"/>
    <dbReference type="STRING" id="139825.A0A401GZI0"/>
    <dbReference type="GeneID" id="38784466"/>
    <dbReference type="InParanoid" id="A0A401GZI0"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="322" mass="35061" checksum="6335B8580831DBFF" modified="2019-05-08" version="1">MGLNGVIVQKYCVQALAAVGAIVLARGAFNYLSFAYFYLLRPSSLAKYFHGAPAYALVTGASDGIGKAVARELYDKGFNVILHGRSEEKTRQVADEIRERRAGDVRYFIADASEPKQDFEAMLKSYKDCNITLVVHNVGGSRIHERVDSMSESSVISTIHLNAIFPLLLTRALLPRLRSSAKYGPVMVQFVGSVTADMSPAGVAVYGASKAFIRAVTRGLDNDERTWGQPSGVRFSYLSVASVVTSSNRGDVTTSAPSADQFAKALVSSIGCGYRSYAPWMVHAATLWVLGAVREGVVDNMMIKEMKKVREKQDFYDGVASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZV2</accession>
    <name>A0A401GZV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1103740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618610.1">
        <property type="nucleotide sequence ID" value="XM_027762809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZV2"/>
    <dbReference type="GeneID" id="38784614"/>
    <dbReference type="InParanoid" id="A0A401GZV2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="91" mass="9482" checksum="B62EAC3549F71610" modified="2019-05-08" version="1">MMHAQYRPTRRPVPPLRAGGDLGTPCTGGAPRMAAVAPSGNSFPFSRWMSARPPPPLPHAPSSPTAACAILPALTLPCHGRDGHADLPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0C4</accession>
    <name>A0A401H0C4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1200890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618777.1">
        <property type="nucleotide sequence ID" value="XM_027762976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0C4"/>
    <dbReference type="FunCoup" id="A0A401H0C4">
        <property type="interactions" value="880"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0C4"/>
    <dbReference type="GeneID" id="38784781"/>
    <dbReference type="InParanoid" id="A0A401H0C4"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="442"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="574" mass="62623" checksum="E0387CA4CEC14618" modified="2019-05-08" version="1">MSHSSLISCISWVRRGVTTQHPVKYVLDDNELNRVSALARIELDDARKELERAHKAAESMGKGAEGEEADDVDDEDESAWVDEDENSKDEDVPMDQDGPPTKDGAEGKDDDDLAQYDLDNYDEDDAIPAMGPFSNIKGLTYYRNNDEDPYITLKDDQEYEEREELEVLPNDNLLVAAKTEDEISQLEIYVYDESQENLYAHHDLMLPSFPLCLEWLDFPPITSPASTASSGAKQFGNYIAVGTMEPEIEIWSLDIVEAIYPDMVLGRPDKTAAHVPTPLGTGKKKRKKAKHRAASAAHHVDAVLALSWNHTHRNLLASASADRTVKLWDLSRNPTISGDSEGEGALRSFSVHKDKVQAVQWNQKDPTVLLTGSFDRTVRTFDSRAPDAGVGAVVGADVEAIRWDPWEVHGFYVSLENGLVLNFDARTLPSDLNSPSPSRFTLSAHDGAASALDVNPHIRGCIVTGGTDKIVKIWNVHEDADLGKQQVSLVTSRDLGVGKVFSAVWSPDDPLTVAAAGSHGKLQVWDVGANAGTRKVLGSKLAEAGRILKEKTGGGVVGVASDDEDSSGGEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0D4</accession>
    <name>A0A401H0D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1201100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618798.1">
        <property type="nucleotide sequence ID" value="XM_027762997.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="38784802"/>
    <dbReference type="InParanoid" id="A0A401H0D4"/>
    <dbReference type="OrthoDB" id="2554033at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="333" mass="35974" checksum="4EBC30F15747DDFD" modified="2019-05-08" version="1">MDPQALSEPEVSPPFRSVYETSPVAPHVIQRRLVQINLSRRISRESDGTTGRRWTIQGQSWKDGCDQRLGPSGGAHSDYRDRRYVKPLSFLPTVSTIASVLFIEIMSSNDSNNVRHSKPIAIDPHRQPRRRSDSASDSSSSDDSSPSPSSPPPQSGFPGTQPHIIPMSPTTSPILSYFLSGQSPKSASTTFPFRRNVGVPVPEDDEVADNESKATKHGRRASTAWAGGERFAQPPPVSGTQQERAAGLLRRLSLGGTLARPQFPNLKPVSGANGATAASTTQRPSTPPNSPAVDTTPRRPRRANTVNPSAPRPPRAPSPMGERILSGHFDGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0H1</accession>
    <name>A0A401H0H1_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">SCP_1201360</name>
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    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027763023.1"/>
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    <dbReference type="STRING" id="139825.A0A401H0H1"/>
    <dbReference type="GeneID" id="38784828"/>
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    <dbReference type="OrthoDB" id="432299at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="718" mass="77837" checksum="4EA45068ADB8199F" modified="2019-05-08" version="1">MAVPRYTPRGRKQSATASNSPEPPPAVHGTSAVSVNSSLLSRLSPRKSSLLSRLVSESEPPVRPNKGVRLVDRLSSSPARNVVELDEGEIIPTGAGGYAGREGSTSVTEEGQLIERGFPQMHRQSSRPLSLQVRLQTRPEDLKARLGIDTSIEQAPSPSEACLEEGEMNDDVQQPERTSSPASEAAVDRLLASVLDLSDITLATASSAVSERADPRPTHSPRSNASPSTVIEECRRLLLPQLIQNAWMRESHLGADGDAIAQRAEDLLTEERCKEFMALAQEVRAQMQRREQLEQEAERGGPSTGTKRPRDVDVQGKEGPERGAKLRRVSTPHSDVSHALGATREPAPQSRLGLIHDSDSIPKAPRAMLVDSSVRAVEEYLARMQVSTVSSDLSQSASSRVTPTPPSLTTMAPTLGTARVRDVQVQNGDTAAVMDTVNDDVPTQFASLPDLPRNTPPKSDDNDGDMPEREESQSTAKPVSQPPPPAVHEPPPSDIQMESSQTESQNPPAGPQDLPHHHLNSVPGLWSVNVGTKGPSMFEFDINIDEEVAGAAERWACRYQEFSLNDAHISVHLLCLPAEVVATANRKLDPAASPRDVAQMLWDIPTAWPQPGTLIVEMNESHPRGAHVWFSEDMGPTNGPLDLTACLHAGRNTVRLLQLGDMSDRLFVVHAAFPSSEERDRAAKRCAGNRDWADFFAKASTRLRPSSTPTVPVPGIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2H4</accession>
    <name>A0A401H2H4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">SCP_1400400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027763747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2H4"/>
    <dbReference type="GeneID" id="38785552"/>
    <dbReference type="InParanoid" id="A0A401H2H4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="59" mass="6437" checksum="7BEC2B2E67A9E04F" modified="2019-05-08" version="1">MGINLEALDILVTVHGIGHDMDIGAAPFRQGLPRFQIAYGINTLFVLFFFSSDNSLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Z5</accession>
    <name>A0A401H2Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassidaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Z5"/>
    <dbReference type="GeneID" id="38785690"/>
    <dbReference type="InParanoid" id="A0A401H2Z5"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="29366" checksum="BDAFA9E13936A04A" modified="2019-05-08" version="1">MLLYDEEPKEKLVLLEGPKYWLPKDEIVRPGVMRETKPVSLSTLCGKYLVVWQDEDESPGERTAASKWRDTVTLERRKSARQRDPDPDGFKGVLQLEHFFGYFHELSATYVRGKQVPNQWELIASDISSPDLPVESLTMEVTNVVDDSGHHFVNFHVDQAYYTSNWLGKKQTKPNVDELLTDAERERLGMRLTAADVEKRAKEGKMGRRGAKRKAKGDDKEPRKKCKEEIIAVGSLLASSSRTIIPSDALAAPLTKDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H333</accession>
    <name>A0A401H333_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1402040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027763911.1"/>
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    <dbReference type="InParanoid" id="A0A401H333"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27928" checksum="20CF01F7438F55AF" modified="2019-05-08" version="1">MLVSRQSLHCLSGLYTIRNHRDWTSISTSHTGLVGASDMFLALGNTGSATHRRVVGDEAIRALPGPGETRPLRAILPSGSVNSLTQFRHPDPELHSDHRLSDESLQVRGSWQKITLPRNIKSRIAFASFIWKSRMYIVGGQRSGTFEVYNDAWCLDLTKLDGWRQLPPYPGRYLMHTEMAVHGNKAYAFTGRATIEYFDLITDRWRQIRTTFVDANGHSAPWPYAENDVDEYAVHIVRGHIYVFGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3I4</accession>
    <name>A0A401H3I4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1403180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619823.1">
        <property type="nucleotide sequence ID" value="XM_027764022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38785827"/>
    <dbReference type="InParanoid" id="A0A401H3I4"/>
    <dbReference type="OrthoDB" id="3192989at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="7">
        <location>
            <begin position="237"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="8">
        <location>
            <begin position="729"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1454" mass="162110" checksum="A06CC4EBF34DB5D2" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQPPEPAIHLIKMSNLSPMPLTDQIAGVLELMFRRKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELERKWPPPFGESEIRIDQPATLVDMHGHILAWILPRVLIPDRQTKMLQATRALHPAIAASKPSSTTATGSLCLSPGWFQQPLQHMESGRLETSASLKLEGGRSWLRDIHDSSALLGAILAVVHPTLYAAGRQCLDLIQQDPELREMALNWSSPFNALQVIANRETPFHRDSKTRYTFYDLLATLGNYTCAWLNFPAMRVAIDYSPGTVIAFCGKAIHHGITRADGERLVYAYFMREGVQNRLGIPAPHWMQASYYASHIGMCTRDIMPKTDGDENTMQGMETVDGSFIGGIKLAEVMAKSQGVVITDGSIWLADLEVGGDGGEMCSVEKLCNKSRLVVDLDDEVEFVTKVAKQTTRGVRYVDVPLPMPTGSNVPSPSKSPSKAPASGSLFNLDDGDVLGNIGVPIQLDPAARKTKTQNDFMRDWIPHRDDYLHAIVEMEAPPEPRNCAECKVGEGRWRCLDCMGRPLICTDCCRNGHQRAPFHRIEHWQGQYFEPASLYRVGVCIHLGHGGDPCPLGAFTAHNNPAPVVAPGSNFWNASNEDLNAHDGEVSDDGEVPFNFAPLAGTLDGEARQTDDAPDPTWEEDVPPVLSRPPRRDSYGNRIIVIVDISGVHHIGVDWCQCEMAVECDMQLLQMGLYPGTVKDPHTAFTFAVLDDFLLENKECKTAALNYYSKLKRVTSNAFPGTDRYRELMRVSRQWRQLKYRKWHGFSHDALHPVEKGGLTIFCPACPQPGLNLPFDWQADPVQWKFKRGFVMDGNFSAEHMKMKHPEEDVALSDGQAFMVGQEDYKAHLAVAMESHQRSTCHEHRAVNQANVDRANLDATGIGATACARHGFFVPHTVVDFQKGERQMNMDYSLSNALLTLTGITLVLVMYDIMCQYGVHVRKRFRHSAYLRMPFELKIDQGIGLFHVHGHQDCCFQRFSPNFIVGAGMVDGEVIETLWAPTNEVSGSTRGMTRAHRQEVLDDHMNDSNWKKTTRMVPTLMTKWKRVLLGFPRSKESFEALSASTDEEVLEAWRKEYDNAMEARQNDPKIMDTFDVQLRKAPGKDLTQLRLAGKESAKGLEKGTAGWLLTGLKIQEAQLKLANDIRKAGQNPSVAEDLKTLEHRQRLEVSILTFQRRSEKFMGRLEDVPAMEDRDDGALWDSLDENPFQIHPEDAEYGEDAIPPEQASLNLPSQIGFVAAVANGLQTLAAQELELRKGLMNDILHELHMALGLKSYLYRKRVRPANSVGTMTRAQAEVHAADQTVLACARLYSANRRAIMRLGATDEDLALYRPLDKKDLHVKTAVIEASTSGLRNVNLAWFWTMDVAGDRGSSEWMDECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3R0</accession>
    <name>A0A401H3R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1500560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619967.1">
        <property type="nucleotide sequence ID" value="XM_027764166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3R0"/>
    <dbReference type="STRING" id="139825.A0A401H3R0"/>
    <dbReference type="GeneID" id="38785971"/>
    <dbReference type="InParanoid" id="A0A401H3R0"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="154" mass="17515" checksum="4F1D454EA7B82D39" modified="2019-05-08" version="1">MRYGEDLSVALISLVTSAAREDHAAYTLQQLSQAIFHARFLYREPLTLLLPLLISCPYDGADKLIHIMGQESSAKEVVMVVQEVAEHLEYLSQAGEQVEEVDCGLSPLKQIDRLVRLYAHCVPRLPKRNKLPSQVMEPLLSARISDNTVWRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H419</accession>
    <name>A0A401H419_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1501930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620098.1">
        <property type="nucleotide sequence ID" value="XM_027764297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H419"/>
    <dbReference type="STRING" id="139825.A0A401H419"/>
    <dbReference type="GeneID" id="38786102"/>
    <dbReference type="InParanoid" id="A0A401H419"/>
    <dbReference type="OrthoDB" id="2368680at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="344" mass="38997" checksum="9FCA59BECD0FEFA1" modified="2019-05-08" version="1">MFCHLDFPRAAAVPNLVPITLPPSLSQRKRVHRWAIILSGLSNEERRRCVLVSRMFRYAIYLSASHLLNNNYSGQRFVQDVTQQYSRAMTNMWPYLRLREAEVLQRRKAYKHSFLAEFFESNGLPNPIADHIWASPDSERQIIVILRFIMTRLWFTLSLGTYNGKNDSRLWLCGIVVDAQEVIKGEIWSVTVLSRPSDGVDPQKVSFHVLEATCEVVGHTLPKDDPAARVIDSVVPLRADWSAYISECLTYPDGHPDDSLLSHIRWTNHEEYTCGVSKLWQARIAREGDLGAAKRVVACVVGNSVSGQWMSAAEMAQDFAGLPTRVPQGNTKSKTQLVNLYLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H498</accession>
    <name>A0A401H498_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1502730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620178.1">
        <property type="nucleotide sequence ID" value="XM_027764377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H498"/>
    <dbReference type="STRING" id="139825.A0A401H498"/>
    <dbReference type="GeneID" id="38786182"/>
    <dbReference type="InParanoid" id="A0A401H498"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019217857" evidence="3">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="64"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE89265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="319" mass="35470" checksum="F05DBC34E50D5F7F" modified="2019-05-08" version="1">MIQKNRYCTKLLALFSSFACLGGAVNDIPITEGTIPFTYQGETYQTYYKVVGDLATVDGSNTPLVVLHGGPGLSHDYLLPISDLAIKASIPIVFYDQIGNARSTHLRDKPSSFWTIDLFVDELANLISSLSVQNSFALLGHSWGGVLGAEFEVRRQPEGLRYLILSDSLAASDLWSQSTAMLARSFPKAVQEGLAAGMTNMEEFRPALAQFNAVHGCTVKPVPKEMTYSFNQIFGPNGDPTVARADILQNWTIIDRLDLVRTSTLVINGRNDIAQDFVVAPFYQNIAEVKWITFEQSSHTPFWEERDRYMQVVSSFLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4H5</accession>
    <name>A0A401H4H5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1503110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620216.1">
        <property type="nucleotide sequence ID" value="XM_027764415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4H5"/>
    <dbReference type="GeneID" id="38786220"/>
    <dbReference type="InParanoid" id="A0A401H4H5"/>
    <dbReference type="OrthoDB" id="3027208at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="285"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="582" mass="67225" checksum="A33332BB631E3BAF" modified="2019-05-08" version="1">MVRTRAQVAKLGPEELEEETGPEGEQAKKVTRQKSKPPTAKPGKNIDDSIYTLSEQEAWSKYRKYMATRIRITMELMELGYKKAAIKDVYNVRAGFRSTADRVNFTEEAWKKMKPELIRILDKSVRADEEALRIQLTNEQSRRYKKKMARLRTILDAFLSTPVAGSLTREEKLVLSFNQDPSLGIRLMPDIAMRNDSEANTTRDLILHWPQIRERLAQAASKFKQEIINLYPRNRFIWHFPDEHFSPTYAIFHLRCTRKIYKVHREHWTLRQANFNKTRSSGSTGNIILISHRTAFRIHRGMLSRHSDVFRDLFTVPQPAIEGRLFDCPVIHLPESPADLRYLLGVLYDGRKFCLGRDEQLRFQEVEVLVRLAHKYQIYDLCKQGLEKLKTIFTHDFATWNANFPDSKGTSEIDVKEKDGIMAITLAYSTGAVSMLPIAFYLCSNLRLRDFHQGVSRHDGTVERLSVVEVETSDVVGKIKLYSDANPRCSRSPLCAKELNAMRLALDSFSNNSIMSHRSLHNSDGNLEALGEGSNLCIPCMRFVGWRDLQRRRDIWENLPSFFGLDSWEWLRADEAESSTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4J4</accession>
    <name>A0A401H4J4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620279.1">
        <property type="nucleotide sequence ID" value="XM_027764478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4J4"/>
    <dbReference type="STRING" id="139825.A0A401H4J4"/>
    <dbReference type="GeneID" id="38786283"/>
    <dbReference type="InParanoid" id="A0A401H4J4"/>
    <dbReference type="OrthoDB" id="3236156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="389" mass="43407" checksum="512E39E19BC1F1C4" modified="2019-05-08" version="1">MEEICDSKAKPGVNHLESNVAKGLQDASTLAELAAMALYGVSVSWPYLSQARGDGSKIVNLLDLTELHRKLPTFCNHIALHPTLLLDSNAPLDEVTLDGKPFMDKMLLAAVCMLAPDLPGLTCMISAMFSGAAKGWVQFTTEFTVGGPFDSLTPAERALVFIPSTNDANEGALGSWRVHARSRPSSTASTFSSQARSERNNTEEFIVKCCNEDDQGGENAQFREELVENQRERAVQYRKKQEEDQRKKDREKERLRSIGLITDRDEIHRMTVAQLKDQIDIHRKLFNDEILLNTTQKSLPNKIMKMYAVLAAVTRNSDWYVLVEAPISFMLSDLAQLLLSLADNQLDLGNTHANTVEDTLIHDTPDLDTIMDDVNTNIGLEADYDIDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4L4</accession>
    <name>A0A401H4L4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620254.1">
        <property type="nucleotide sequence ID" value="XM_027764453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4L4"/>
    <dbReference type="GeneID" id="38786258"/>
    <dbReference type="InParanoid" id="A0A401H4L4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="111" mass="12366" checksum="88B734C2DA643E2C" modified="2019-05-08" version="1">MDLQSISFASPCGVELYRFDCYRNSYLNVIIHAAWGVVVRAWRSSVYANSLVHTGRQSDNWDDLSNMFSPCNVENERGFTPAKIACAATKYPEKVSASFIRTRGGLSLHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4Q2</accession>
    <name>A0A401H4Q2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1600530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620305.1">
        <property type="nucleotide sequence ID" value="XM_027764504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4Q2"/>
    <dbReference type="STRING" id="139825.A0A401H4Q2"/>
    <dbReference type="GeneID" id="38786309"/>
    <dbReference type="InParanoid" id="A0A401H4Q2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="981" mass="105077" checksum="0E702CB71800CEA7" modified="2019-05-08" version="1">MPGIVISALLEFTRAYQQKALARLDHISNDDERIYKRYLWLCASMGSVRTWEGSGGLKLPPVKSMPAEGWGNVPADDDTQGRGEEDLATGDLITKGKGKERADNDVGTGMVAAPSLRKRKAVITESSEESENEEAAPKAKRMKPIEVAKEKGEAPTTSGRVQRAQKRMAQTEVEGLKVSTKKSGKRKAKESSDEEEVLTVKLPKKKRATKEYKSKEFIESEDETPAPPSNLPAKTAGDSNDGVAKTNAPAKPVKQTTRMTAMPHVAPKGKGKGKAKAMAKATAKVKAKVDGDGVAEGHSCSSPCVGCQEKEWPCKLNTANFGRCLECAAQGVSCSIAPRNTDGVSLRGNSHTTQREFQEMCAALVVEGKPLPTSPPPYDVKVDSDEPDGAEPMVMGASKCKPLKKTKMRNAAASSSKVKDGEEVEATKQKVTVTPDEANPEGEALVRNHRSPSAPPSPPPPLELWLCQTLVRSPTLARSPKSGAPAKSGAVTKPGEGKKSGPKPKPVRSQNSGVQDGGEVTRTSVHKADEVPPAKSVAKEGGQMTRVAMGGHSGPMVPVITKEGEEGDDMEEAARLAMEAVRAMAFQTGPAAPPQASSSKRMLTPVADEPDDAPEYQAEVVEDECVSLERPHDDRQCSLLMPHKMSAGAAEVAQEVTPSLEISKVSKGVKSSTLAKAGHLDEGRRPAKRGTSLDRKAAKEGGGGKKGCEGEPPQSSASDQQGDIAPHLHDIQRVSTGSPTLVNEGDTPSGEETSQSSNDDCANCAELQQEFLAHKDRMEVQFQERMADLNTIKAEITAALQRINPPSTFQGNARSIHKEVKLAMEEFRRPVTIELQESVKLAVADLVAKRHCLPEKVNRLEQGTNQTVSQADVEKLQGELADLHHSMELQAAWSDSMEKELRSSAAEAIAQASKLEMELALAKEDSMAVATSALDEVKKVGKEVAMAREETSLVAKSLDAFREKVDSAMVFTAFRPDSHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H518</accession>
    <name>A0A401H518_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1601760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620427.1">
        <property type="nucleotide sequence ID" value="XM_027764626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H518"/>
    <dbReference type="STRING" id="139825.A0A401H518"/>
    <dbReference type="GeneID" id="38786431"/>
    <dbReference type="InParanoid" id="A0A401H518"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="313"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="471" mass="51152" checksum="1A9990C7275C4419" modified="2019-05-08" version="1">MFPLNDFNLVCCALATVSAAFGYNVTRRRRSHSLNTQRLAEEERKREVLARSQSVASMFSSCDSTMTLDSEGTGSEPPVSVYPSPPESVNALDDTEPGTLKRKNRDEGNNDPDGETHGAAKDRSSSPPRKRCRTPPASYDPESTVKNEGEAAMTSTQTVNIITADQQQLETVPAVKVVVADGQQQEAFFSGETATQIKIEEPDIASQTPFSFPIPKPHSECKPSIFSSMQPIPAVKPSTAFKSFAGSSSSFTTTSTSSISPRSGFKPVWCSGSIILNAPSSTELTTSQDDAQAVCDAALSSGEGSSSLKASTHEDPLAAHLYSKSTHSTLTGEEDETIRAELKGAKVYVKRGGREFSDGILGHAKILVHKETGEERILFRREQVWKVTMSVRLRPTVRCTYDEEQGVLRIVLKELEEREGVPPDQWKQQVVIYALKRGKASKGDFAEFSRAVVASGQLCAQLPPDLRSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H531</accession>
    <name>A0A401H531_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1601840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620435.1">
        <property type="nucleotide sequence ID" value="XM_027764634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H531"/>
    <dbReference type="STRING" id="139825.A0A401H531"/>
    <dbReference type="GeneID" id="38786439"/>
    <dbReference type="InParanoid" id="A0A401H531"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="298" mass="32940" checksum="04AB01485BA179F5" modified="2019-05-08" version="1">MVMANTTCGICLDELKVPVSTPCGHLHCEKCLTAYIEKSPDAITASCPTCRSAFGIAMPDMRFVPEKYHKFIIPNVRRVFLDAPLHTSSDLQVDVTRLEGRVQELVHDKTLLMDRCEAQMAASAIHASGERDARLENEKLKMEMQKLRKKYDGLKGKYFSLRETSGVSTHAMKRKSGQAALDTFLEPSQCRSGFDTREVDGRLVHRKSKRPRLLGSPFDLNHLAGPVPVFKKRLPISQPEDSSSLPSSLGSKARPRRSGLPTGDLFSPRIGGLNGGHGSIDYDYGTATIPLVEDNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H564</accession>
    <name>A0A401H564_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1602160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620467.1">
        <property type="nucleotide sequence ID" value="XM_027764666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H564"/>
    <dbReference type="FunCoup" id="A0A401H564">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="GeneID" id="38786471"/>
    <dbReference type="InParanoid" id="A0A401H564"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="172"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="347" mass="38177" checksum="9D7F658DBD475341" modified="2019-05-08" version="1">MAPVTNGRLLFNEIPTGYPEPGKTTIYDTSQTIDLEDVPLDGGVLIKILVLSSDPYLRGRMRDAKIETYSASFQLGKPIENFGFGVILRSEDPAFKRGDHVFSRKLPFQHYSVFKKEELGTLRVLKNEYKNLPWSVYIGVCGMPGATAYMGWKEYAHPKKGEVAYVTAGSGAVGGLVLQLAKADGLKVIASAGTDKKVAYLRELGADVAFNYKTVPVNKVLQKEGPIDIYWDNVGGESFEAAITAANRLARFIECGTISGYNIQTPYHVKNLGLIVGKELQISGFVLSTLYAKYKEQFYKEIPKKVASGEIKYSEDVTEGLENAGEAILDVQLGRNNGKKIIRVANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H686</accession>
    <name>A0A401H686_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1702250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620812.1">
        <property type="nucleotide sequence ID" value="XM_027765011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H686"/>
    <dbReference type="FunCoup" id="A0A401H686">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H686"/>
    <dbReference type="GeneID" id="38786816"/>
    <dbReference type="InParanoid" id="A0A401H686"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="544"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE89899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="665" mass="73552" checksum="F80D5165CE6656C1" modified="2019-05-08" version="1">MSDNDVPVHEPVPTHPIAPRLKSGQKKPHVGPHIHAYREHHAQTVGHESDKWWAQMARETLHWDRPFHTVRAGSFENGDIVWFPEGGLNASYNCVDRWAFKHPDKTAIIYEADEPNEGSLITYAQLLREVCGIANVLKSFGVKKGDTVSVYLPMTWHAVAAFLACARIGAVHSVVFAGFSAESLRDRVQDCKSRVLITSDEGRRGGKSIATKVIADAAVKECPGVEHVLVLKRTGNEVPWTPGRDKWWHEEIAKVPSYCPPEIMSSEDPLFILYTSGSTGRPKGVVHTTGGYLLCAAMTVKYVFDVHPDDKFACMADVGWITGHTYIVYGPLANGVTTTVFESTPVYPTPSRYWQTVDKHGITQFYSAPTAIRLLRRLGDHHVKEHDLSTLRVLGSVGEPINPEAWHWYNDHVGRRQCAIVDTFWQTETGSIVVTPFPGAIETKPGSATVPFFGIEPAILDPMTGEEIKGENVEGVLVLKTPWPSIARTVYQDHKRYLETYMKPYPGVFYTGDGASRDEHGYIWIKGRVDDVINVSGHRLSTAEIESALITHNGVAETAVVGTADELTGQAVHAFVTLKPEFAYDPNDEAGLLKELVLQVRKVIGPFAAPKRVYIVPDLPKTRSGKIMRRIMRKIVAGEGDQLGDLSTLAEPGVVEIIKQKVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6E6</accession>
    <name>A0A401H6E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1800390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620930.1">
        <property type="nucleotide sequence ID" value="XM_027765129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6E6"/>
    <dbReference type="STRING" id="139825.A0A401H6E6"/>
    <dbReference type="GeneID" id="38786934"/>
    <dbReference type="InParanoid" id="A0A401H6E6"/>
    <dbReference type="OrthoDB" id="2803547at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="565" mass="62118" checksum="F4C8B22650D5BC00" modified="2019-05-08" version="1">MEHIPSLTRALCTAQSLVSKLRKTGGHESLDTLYTLEEVLASTLSTVRSSINIFSPINQCPNDVLSIIFQYAVALINESAGEFQWPFSSLRSSPRLIDLTHVCRRWRVLLLDRPLLWTHIGDHLGSDPLLRAAPTFLERSREASLKLHVRVMSARQMQTISHFFESNLSRIEELHVKHTPDLFGLHHSAPALKVLTMESVQKSPGQTVFAGDVPLLRALTMQSMSWFPKNPLPSLTHLCIYSKKAPGTNHGGFQHYITSLLSGLADFLDACPGLEELIVSDAPLLVVPSTSDRPPVTLKHLRRLSIGEMPIGVLSWFLTHIKSHDELSTRIFGLRCDGPSSTLSLPNIPPLNGSTILHVGTSSPFVLVVTATDSSAAVRIECGIPRLRKLHTVPDGILPWASWPLSTITELHVTGSKCVSDFGGLPTLFRALPSLSVFTYVGGLNRLRFILSALTNALSPFATYPLPCPSLATLQICFDSESYMICEALAEFAATRARAGCPLRDVVIQCNDPGAIDDGILPGFNLIKHVQSVQYGQSRGVTPAVRWPAAACMGNTHMFWPLWQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6Z2</accession>
    <name>A0A401H6Z2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1801750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621064.1">
        <property type="nucleotide sequence ID" value="XM_027765263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6Z2"/>
    <dbReference type="STRING" id="139825.A0A401H6Z2"/>
    <dbReference type="GeneID" id="38787068"/>
    <dbReference type="InParanoid" id="A0A401H6Z2"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="274"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="588"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE90151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1264" mass="140821" checksum="99E9C7F644F7095D" modified="2019-05-08" version="1">MSRSLTAPYTDRWADVRWLSRGGKEGQGPRNQNLKKDGDKGKSGTSANTAVSSNTDVHAFTATFDSAALARSHTADGNIRIEVYDSSATRHISPYRDTFTAFEATPPKPITAVDGRAFHATGQGTVALKVPNGDQWTTVMLQDVLYAPDIAFALISVARADAAGYSAIFEQGECHIISRSKGRIVGRIPSNNGLFHVEHACTTAGIVLLPPGDVVEHGLVMTSVMDFHRRMGHISPMIAERLVREGRVEGVRLTDSAKPGTDQCESCIQAKIMRHPMPKERDGARAKELGDRVHSDVWGPARTETIGGKKYFTSFTNDATRWTELYLLHAKSGTFQAYKSYEAKLSTQDGKTVKALQSDRGGKYMSADFKAHLAAKGTASRLTVHDTLQHNGLAEHINRTLLEHARAMLIALGLPKSLWGEAIMHATWLKNQTSTRALEGKTPYEVRYSKVPDLGNIHEFSAKVWVCIEDAGKLDSKAHEGRFIGHSEESKGYHVYWPDKHSITQGAPTGTFSSGQPRTIWKYNTLFHITMEHSKEDGMLPPIAPQLLVDMHISRAEEAFMEIDEQVTEEWRLENEIPNTDVIEETREGLAQKRNRAPSTVVKQPRRKAARYVISDDTQPERARATGGPSVSKTLSVPAPEEEMASRTIDPPTPATPTPLSSPPEAPAPEAPSGRGHRVRKASAYVQRLNDGSGVADGRLSQSKYPKGLQPGDLMGAVAIEAESKDEVESIFMMPALMETPRQDPASLNEAMQSTEWPKWTEAIAKEMQNLDSHGTYTLVEPPKNTNIVGSKFVFRIKHNAEGEIESYKARLVAQGFTQVPGIDFNETFAPVAKLASIRLILTLAAHYDWELHQMDVKGVYLNGDLEEEIYMWQPPGQAEPGKEHLVCRLKRPLYGLKQSGRQFHKKISGELGSMGLTRSKVDHCIFWLRNEEDVLILLIALSVDDSTIAGTKAAVFWFKREISMHFEMSDLGEMHWILGIEVRRDRDARTLSLSQCAYIDMILARFNLQDAKSLTTPLDPGTVLSIHQCPSTPRQFEDMKNIPYREAIGSLMYAALGTRPDIAYAVTALSQFMKNPGRPHWEAAKRVFRYLAGTRERWLTFGETTDGVEGFSDADWGSAEHRHSISRYVFLLDGDAVSWSAKKQNVVALSSTEAEYIAITHATKEALWLHSLLADVLHPDILRYPVRLHSDNKSAIALAKDDAYHAHTKHIDIRFHFIRETVENGQVILQYRRTEDMPADIFTKVLPRIKVEHLSRLIGLHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G569</accession>
    <name>A0A401G569_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0101770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608217.1">
        <property type="nucleotide sequence ID" value="XM_027752416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G569"/>
    <dbReference type="STRING" id="139825.A0A401G569"/>
    <dbReference type="GeneID" id="38774221"/>
    <dbReference type="InParanoid" id="A0A401G569"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="645"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1004" mass="109711" checksum="E0C0F23B5B491983" modified="2019-05-08" version="1">MPSNFFSKLVKNASSQYAPEHPRSPSPSPKRQLPSNGVNSASSTASTSRSRSYSESKPRQPSSEDESSDNPNVTVVPPSPRSASQGSDLTDEDATPRAEVPPTLGKHYGNGTIDSRKRRPSSLAQVTTNAPPSQTTTSAPTDEEGLATPTPASRTTFHEQPAPEHTISPVRSFGNLRKKSPSPNHPRSSTIATDQSRTPQSPLEVSHVPSAATQKSSSQGKSSRSKKSKAKDVQLPSRHERSASVPSTFSSSSLPQPPNISVMEDGTITSPTVSESPTEEMPSMRLLSSNTLPNFSSSLTVPDNADAVSIRSNSSTVTTSKKMRWRRRSTHSGNAPAPGQSPSANVSSTSLSPTKRKGTGSSLASALAVPGGLVMSSAGMSIPPISVDTPSSPGNSSLSSRKRRDSDFPRTPPSGRSRRTSLSYPTSELSDRDSFHSGEDIIGLSEDDDDDLDLDPDDIPVTGFAVASNKRNQDFHEQFPTIPEGDYLIEDYGCALQREILIQGRLYISENHMCFHANIFGWITDLCIPMYDVTALDKRMTAFVIPNAIQVTTHTAKYTFTSFLSRDTAFDVIFNVWRLARPETSSIGSLAQSPRGSLDGPSGVMEAGVATRNGNGLATPPGEVVSGKGLRGKVTRCACGRAGEHFNEVAMESVLPGTPEKIYNLMFTSGFIKDFMRDDQKLTDIQISDWMPTADNPKLLARVMSYIKPLNGSIGPRSTKCELRDETIHCDFDQYVAMMTTTRTPDVPSGGVFSVKTRTCITWASSISTKVLVTTQVEWTGRSFIKGIIEKNALDGQRMYHADLDKAMRDYIHAHQSEFIPEGVDAAAVEESTEAQAPEVPVLAERPQPSEEEVRKSREYERNQRGLQWAYETFEGTAKVARQSTEGALELLRDAWDQSSTTTILYFVIIFLAISNIWTLGMVGRKEEVGRRKEMKRTDEREKWVQGIVQALWEELIANRNTPGAAPWLRSTGDWKEEVAEINVVLDAIDQRVESIRESLKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5A8</accession>
    <name>A0A401G5A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0102210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608261.1">
        <property type="nucleotide sequence ID" value="XM_027752460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5A8"/>
    <dbReference type="GeneID" id="38774265"/>
    <dbReference type="InParanoid" id="A0A401G5A8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="123" mass="13642" checksum="6AA6A6C735568F1F" modified="2019-05-08" version="1">MEDAQQFRAPAMKVGGRRMSVTTRPKHPPHAEPKPPSPTNEPVDYPRPAPPGEQAPEHAPHEEEHMKKEKKKGSTEHDKRFQENLYQRAEHNRPSKDVHGAKNINAIGAGGRIGQPAGRSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5R1</accession>
    <name>A0A401G5R1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0103770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608415.1">
        <property type="nucleotide sequence ID" value="XM_027752614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5R1"/>
    <dbReference type="GeneID" id="38774419"/>
    <dbReference type="InParanoid" id="A0A401G5R1"/>
    <dbReference type="OrthoDB" id="2767002at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="638"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE77502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="698" mass="77450" checksum="B52D21EF75ED100C" modified="2019-05-08" version="1">MNSDTPALNADGSLKSAKDMELDHSPSSSVAALPRPPDLLSVRPITFIEVQPGESSSKGKKRSGLDNINDISTKKKPHITTSVQTRKVAPKVKATLRPATEHLLLPQPSAAASETILGTPQAPANASTSTATESSALNVNEIVAVAKKAHKKGNVVADISTICTLVPRDDGSKHALKKSNHVKFGKLQTMFKGNHSTMRTHIARQGMSHYNVYQERQSSILQYAEVKEKSVKWSKEGLEENILQFVVETDQALNITEHASFRGLLQYQHRKSTDKDIPKHTYVTTRIIGHAAEIQKELAKKLQDAPGRVSLTFDGWTSAIMRAYLAVIVHYITDDWKLWTELLAFSELEVNNKGMCTLEVQLKNDKIAFDAKEQRSHCFSHAVNLDGEVVADEDETKDDVEVLVKEVEATIAALPPNLKGSTTIAALLLSLIIKAVISFVSLADDSDEVPNVDKDQRGYSYYRLLSEDWNHVQLITEVLHAASLVQELFSSETVPCVWRILSGYEKFIVTWQEMAKRADMYALKEAILIGVITLEKYYNKTDNSSAHIVKLYLNPCIKNEYFIAFWDSDGQVHAQTVMEAVFDKYSVKHVSLNRSSASQGTIVVPVPASRSYGSSWLATATAGRRAHEKDMVRDPRAELKQYLDEDLLSLEGGNLTGIPQWWKVNGTHFPILSSMAWDYLAIQGSSVPLLQQDDTSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5Y2</accession>
    <name>A0A401G5Y2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0104620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608495.1">
        <property type="nucleotide sequence ID" value="XM_027752694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5Y2"/>
    <dbReference type="GeneID" id="38774499"/>
    <dbReference type="InParanoid" id="A0A401G5Y2"/>
    <dbReference type="OrthoDB" id="2954746at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="361" mass="39143" checksum="5B86E968D7F604E1" modified="2019-05-08" version="1">MTGNELLSSHGEDGSVTSSQYVTAPSAFSDWSDSEDTNPVLQVSDADSGVIFEEVRQGTNVEAQPAQLVLNGQIDQGNCFVAPTNFSGQTLRDERRLAPFDPSLPAFTLTIPTPQLPPSPVFVLKSPITVSKFVSASSNPANAGISTAIRGSPAPMVPACDRCRLAEPESSQCYSCYQQWLACKVWYQANDGGRRAWLTEPYIKPAESNAINRAVTETFWSPERTPFDPRGLGILTDALIGSSIQAEGFPHLIASSTGSREVVAWKPRRGGVLLLLAESWRASVNALKSKLSSCQRRIALEFKTLRVAEVPDGWSCHMNLGSEDDALLDACFEQPHRRAKITSSSKFVEQLFDSPSNASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G652</accession>
    <name>A0A401G652_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Meiotic recombination protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0105180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608551.1">
        <property type="nucleotide sequence ID" value="XM_027752750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G652"/>
    <dbReference type="FunCoup" id="A0A401G652">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G652"/>
    <dbReference type="GeneID" id="38774555"/>
    <dbReference type="InParanoid" id="A0A401G652"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="93"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="272"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE77638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="334" mass="36679" checksum="0D8F56C9D919DC81" modified="2019-05-08" version="1">MVRRTPSQPAPSRPSSPQAEDVEEGPYFDNVDELQQHAAAINTVSGVNMTTRRQMLKIKGMSEAKVEKIKEAAHKMLGSSFATGLEVQEKRKRVLTISTGSKSVDTILGGGVMSQSITEVYGEFRTGKTQLAHTMSVVTQLPPDMGGAAGKVAYIDTEGTFRPDRIRAIADRFGVNGDMALENILYARAFNSEHQMELINECSIRFAEDKDFRLLIVDSIMALFRTDYSGRGELSERQQKLAQMLSKLSKLSEEYNIAILMTNQVQSDPGATMTFVAGGALKPIGGHILSHASATRMFLRKGRAEERVAKLVDSPDRPESEASYKLDEGGWADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6J3</accession>
    <name>A0A401G6J3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0106670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608698.1">
        <property type="nucleotide sequence ID" value="XM_027752897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6J3"/>
    <dbReference type="STRING" id="139825.A0A401G6J3"/>
    <dbReference type="GeneID" id="38774702"/>
    <dbReference type="InParanoid" id="A0A401G6J3"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="380"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="966" mass="103377" checksum="9631F73010C2630D" modified="2019-05-08" version="1">MSTVKVPAGLGLDFTQSPEESKKSASTISQARLTTSSSWQTDAANVSRFSSLSRASPQVPRFDTASLRSIRGMQGLLMAEIGEAMVELDPSGHGSVFKEGQRIALASASPGTTSINMHPRSSMIPAAGVLVRSETYLNFGASPTRSSAELESLLGNSNSRLKPGATMLPSSKHSHLGKTVKKAKRDLVSLEQAKPRARVEVDIVLENDAYVQGSYLRGHIKLRVRKRSKKEAPMLLAGAKVRVIGFECLSSAKERHTFYQCAAPLSDITGSSSSLYEAEPDVEGFAPAREGVHTISFTMQLPVQGPYGVAKGVPSLQSGVAVQYIAMVSVKVKDSSSGKRSIAHFYRNCEIWPRIDPTVALAPATRPLQATTSKSIAMLSNSKVKLTALLHRLTFIAGQRCYVRVAVLNETKKTVKSLTLTLVRTTTIFKPKPALDAGRTLSVDPDACETSTAHKVVVETVLEMGHRAAKGHASAKGWWTGVGPGEELEFSHFILLPPDALSVIRGRLLEVEYSIRVSLSAGSLTSDVFVTLPIRIINFMSIDPTPNNPGVASYTRTVQRRRSIDGELGSDAPSMNPSSITVREETEIMHGGHSMVPNHQRLPCDVEPLVHPSPAAHAGYEGVPPDTPGLRIANPDRWSAEIPPIPARAAEDSSAYSSDARSDFVSSASSVDVSTTESESESSRSIRLGNMDLDDPDSDEEVDFVVERALVDDKSASTSRFSEDDVPSSPCAFRSLGRRPSGPRARERHVERGRKGYPGARAAVHPPLPQDGISSFAMRVQEKLASLAAAVIQPEYSAEDEVTPRLGHGDVDYEGTRAPVSSPRLSSLEGMRGSRQLPRPPPMGSSMSTSTSSISASTSHCDEMPESGMSNASLTDAALDGCALPSRTTSTSSVPSVYSSASRPSLSRGPSDWPLSSSVPPSPRAHAERPTEGLRATGTSSNSVKGRIAELGERVRYPHDTGSAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6V8</accession>
    <name>A0A401G6V8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0107750</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608806.1">
        <property type="nucleotide sequence ID" value="XM_027753005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6V8"/>
    <dbReference type="STRING" id="139825.A0A401G6V8"/>
    <dbReference type="GeneID" id="38774810"/>
    <dbReference type="InParanoid" id="A0A401G6V8"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE77893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="106" mass="12332" checksum="2DD18B430B9786C5" modified="2019-05-08" version="1">MPSTSMLRGLQLRAPRSLPSFRRYASHSHGPHFNQPSGYIFGEKPLPPGQKRKREDWELLWYIGMFGSMAFAAVFLYYKPDTSLQTWAYNEAKVRMEARGEKTDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G851</accession>
    <name>A0A401G851_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0112080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609236.1">
        <property type="nucleotide sequence ID" value="XM_027753435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G851"/>
    <dbReference type="STRING" id="139825.A0A401G851"/>
    <dbReference type="GeneID" id="38775240"/>
    <dbReference type="InParanoid" id="A0A401G851"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019449618" description="Alginate lyase domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="5">
        <location>
            <begin position="255"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="661" mass="70914" checksum="4F8509845DF857A2" modified="2019-05-08" version="1">MRRILAYLSLSAAVGFAISPNNEWVNIDYLLKQAGGSGSSDTSGARQQIVSSAGGTAKAGPWGITTKNPVLPPSGNSHDYLGWAPYHWPDCNWCSKGATHLMNPSSGGDEPGNPSGGPDSSDPGDDGNSDDPNDPDGDDEDILIVPREAGDFSAARGDVFHPRHRMKHVRRATNYTTSGVADPPRIRYLAFRSPDDTTSPLDVYAAADLDSLPTTGTLSAPALPTQLPTLGVTPALTDGSSQTSIGTVDGTPAPAQAPAKTQHSSCTPSPTKSLSPSATWTTCPYQVRDGKLNPDVRSLPDSPAVIDMTESVFYNCVAYVLQKTSTFSKNAAGFIDAFFLSPSTAMNPNLNFGQLVRGPGQDHQIGTFTGVLDLRGMVKVINGIQMLKAARSPDWTSARDKGMLAWTNQYVSWLQTSDIGKQTAAAPNNHFSFYVNQLTATKMYVGDTSGAISTLQSYFSKQYLDQVAASGEQPFEAVRTRPYHYRCFNLEAMIANAKMGDQLGLNLWTSKSKYGATIQTALDYTMSLDPKDEDVSDIFPHVAAVAAAYGDPKGKYAAFLQKQVSDYKSMPFWFYDQNSALPNAPASHTARDLGELEHSSTAAGTERAILDTITPSATIPFQCPTVFATATEVAIDDGIYVTCDELKPFYEIVMPLESNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8E2</accession>
    <name>A0A401G8E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0113060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609331.1">
        <property type="nucleotide sequence ID" value="XM_027753530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8E2"/>
    <dbReference type="GeneID" id="38775335"/>
    <dbReference type="InParanoid" id="A0A401G8E2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019578969" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="5471" checksum="D665C462F4C35CB3" modified="2019-05-08" version="1">MKFSLCLLSLALLTSLVSASPVAAPDEIVSREEYGMLVDRQFGGDSCCSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8I1</accession>
    <name>A0A401G8I1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0113790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609403.1">
        <property type="nucleotide sequence ID" value="XM_027753602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8I1"/>
    <dbReference type="STRING" id="139825.A0A401G8I1"/>
    <dbReference type="GeneID" id="38775407"/>
    <dbReference type="InParanoid" id="A0A401G8I1"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16920" checksum="0EC2B57D4CB8814A" modified="2019-05-08" version="1">MPETRTMLGTATANNCDVNTDGNSGCGVQNPSSNSFGPDFNSAGGGWYAMERTNSYIQVWFWSRTDGSVPSQVSSGAVSSIDTSTWGEPTALFPDTSCDIADSFGPNNIIFDLTLCGSWAGIASVYSDAGCSSDCVDYVNNNPSAFTNAYWDVAGVYVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8X4</accession>
    <name>A0A401G8X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0115010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609525.1">
        <property type="nucleotide sequence ID" value="XM_027753724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8X4"/>
    <dbReference type="STRING" id="139825.A0A401G8X4"/>
    <dbReference type="GeneID" id="38775529"/>
    <dbReference type="InParanoid" id="A0A401G8X4"/>
    <dbReference type="OrthoDB" id="2723779at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="548" mass="64324" checksum="5DF6A25D5D001EB9" modified="2019-05-08" version="1">MAMLLPTITERDTFTSQSTDLEPDIEWKNTTIKQIEALLRPAVDEAKAQRDRGLGIYPLDDATREKICKEYDRTIEGIRRLAQEQLMHALEQERQTRRWAAGGPLDVGWNETLAREQLGILDGIKRKGSVQQHDLSVVQHSVDDQNRDTTDGPSRKRKEAENRLKEAEARRRDDEIRRKEQESRRKEQEVNMKEEETRRKEKYVKRREEELRRREEDLVRREQEAILKGQDEDFLKQQEEMFRRAAEERKRQDSMGSTSDISRPTAGRSHASVPPSNPWPIPKSSSTASSSSWTSSASGWSSSGRSNGSAYTQTSKPSYAPSTPTATSSHTASTPSPSMKPPPQGRSTGGSTPTQKQKQEEVKQKEAEAKRREAEAKRKEEEKRLEAEAKWKVAEAKRKEEEARRVAEEARRKEEEARRIAQEAKRMAEEERRKEEERKRKEAENRLKEAEARRRDDEIRRKEQESRRKEQEVSMKEEETRRKEEDIKRREEELRRREEDLVRREQEAILKGQDEDFLEQQEEMFRRRLATVLLRDRHTHHSIITDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8Y5</accession>
    <name>A0A401G8Y5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0115070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609531.1">
        <property type="nucleotide sequence ID" value="XM_027753730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8Y5"/>
    <dbReference type="STRING" id="139825.A0A401G8Y5"/>
    <dbReference type="GeneID" id="38775535"/>
    <dbReference type="InParanoid" id="A0A401G8Y5"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="269"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="432" mass="49178" checksum="12360BD5D6BAD8E5" modified="2019-05-08" version="1">MAYYAYDSRYGSGFPRRRKNAGSIVGRFIIVDQEPEEQSEEEMNCNEDFASDDERVESDEESGGSQEDDEMEEEELEKEEAQPKEPGEPCSYSFRSRDRVWVKYKGRWYSGTVLRESSISTSEKTYYRVVFHYNVEMAFSPLDGNIKPDTPYILKLLQDAGEISSLTRHLCIMSLLQDVLRTQTLDSLDKQLGVAADHVQNGRTTPNQEREDSDDELVNVVSLPGTPARSRPASRPPSPTRGAASRRPPGPLHISSARNMSDPLKAFQTELSQRIFSLLSLKDLATCSRVSRKWNKSQTLNYVWFQHYRKDNFHDESLPPGKWTKRESKQNWRTTYLQSIATRTPPLGPLRPSSYSGRSSPSHSGYQTPREMREERWRLEAEATFSPSKVEMREMYKELGGRKARGKNKVGASGGIRDKGGWAAAEEGQNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G981</accession>
    <name>A0A401G981_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0116080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609630.1">
        <property type="nucleotide sequence ID" value="XM_027753829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G981"/>
    <dbReference type="STRING" id="139825.A0A401G981"/>
    <dbReference type="GeneID" id="38775634"/>
    <dbReference type="InParanoid" id="A0A401G981"/>
    <dbReference type="OrthoDB" id="3268553at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="59"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="300" mass="34113" checksum="5789160E2EF8B0EE" modified="2019-05-08" version="1">MSTPTSSNDECIEALEDDDTSAEDAEDLPPTKKPKKTLRDRSARGLTAERHAIIVVVYQHFKLMLCTEGAYPVSADEDRMIAEAWTIACGEKETPDDLVPTEQERLLVRTRATQVRSALKSLARQLLEKHYGFKQGLTAEIKEYNRALVALLKPKVAFAHIDPHNPTTMCRHPIIAEIITRMWFKDAEDDGVHHPEYFENGLVMLLALVLTEIECAIDEWATGIHRAVELRAPKYKQNYERHLQELRKWERYSSTRSKAPQCMQDDLLKTLRANAGVSDQSNNSAAEEDLSDDDFATYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9B8</accession>
    <name>A0A401G9B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative indole-3-pyruvate monooxygenase YUCCA8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0116560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609677.1">
        <property type="nucleotide sequence ID" value="XM_027753876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9B8"/>
    <dbReference type="STRING" id="139825.A0A401G9B8"/>
    <dbReference type="GeneID" id="38775681"/>
    <dbReference type="InParanoid" id="A0A401G9B8"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF26">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="599" mass="67531" checksum="E330078A6290BE10" modified="2019-05-08" version="1">MSDTPKPSLPTLDKLGVTIPDDLDVQAVASGWFNAFSQQVSAHNVPGVLSLFVDDGWWRDMLALTWEFRTFHGAKNLQQFFEDRLAASKFSELKLGTTSLEKYAEDVVFLEGFFTFETDVGIGSGIFRLVPSESGTWKAHHVYTNLEELKGFPEKTGSHRNFLPNHGKWLEQRAREREFLDADPKVIVIGGGQSGLDVAARLKLLDVPTLVVEKRKRIGDLWRHRYQALCLHDPVWYDHLPYIPFPSSWPVYTPAQKLADWLEFYAESMEINVWTSSTLKHFEQREDKTWDVTVERADGSERKLHVDHVVLALGLGAGSPNMPSIPGREEFQGQVLHSTEHNSAKDHLAKKVLIIGASTSAHDIAGDYVDHGVDVTLYQRSPTHVMSTRNGMPKLLDRFYWQGRHPTEVADRLNASFPTSLQVFFWRRIIDDIAQADKPLLDGLHKVGFKTYAGSEGAGFIHLSMTRGGGYYLDVGTSQLIVDGKIKLKNDSPIERFIKTGIRFEDGSEVNADVVMFATGFDSPISAIAKLAGEELASKITPIWGLNEEGELRSAWRWLGVQNLWFMMGNLSWCRFHSKHLALQIKAIQEGVYGERYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9I8</accession>
    <name>A0A401G9I8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0200220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609738.1">
        <property type="nucleotide sequence ID" value="XM_027753937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9I8"/>
    <dbReference type="STRING" id="139825.A0A401G9I8"/>
    <dbReference type="GeneID" id="38775742"/>
    <dbReference type="InParanoid" id="A0A401G9I8"/>
    <dbReference type="OrthoDB" id="3268553at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="312"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="574" mass="64790" checksum="BA4853044BF599C7" modified="2019-05-08" version="1">MSLTLCPIIPPVDTAGRAMVTNASESELQRRDSVEPRSTERDKYLHEFSNLHLLLHPQDHSQSQENDPSHLCPISNPPSILYMSTQTTRVTSGRHRRLTEKENQRVTEREDTIRRKADKFKKSDKADRRARLRQQEADGEEVDEGELIASDIDDTEDNMVINSLRPAGLPPDFAFEFTERTVTTKLSAKKSLAYRSEKVPLAPVNNKGPKRGDVPMLVSSSDEDDDVAPVVPRRILPRKKVTRALIDDTENATTTTPVAMCMAKKHPRDDEDEDNDNDNGLLSPKYQKSTDGPKRPRAKDFDDFTQEVLAIAISVFRCKVSSKGPFPDTSTFETEMAQQAWQEACTKTGLNVALTPMLLKMITKRTSHVRGELKTKVRGVIQSFFGFRSGENKKTIARNRQHAEDLKDGYTFVYADMNKKTGLYKTEIIQMVINDMWFANKQDEGIRYHEYFNPISDVTIALVLAAIECGIDEWATGIKEDIAFSAASYKEVYEAHLHCLEDFEKHTVKYGIVRKLRETLHSNARFHSGAEPLSKTMVPALGVSAFDAAIREWEDPEAEDDDEEVPEGDLSPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAE1</accession>
    <name>A0A401GAE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0203530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610069.1">
        <property type="nucleotide sequence ID" value="XM_027754268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAE1"/>
    <dbReference type="FunCoup" id="A0A401GAE1">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAE1"/>
    <dbReference type="GeneID" id="38776073"/>
    <dbReference type="InParanoid" id="A0A401GAE1"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="71"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="199" mass="22255" checksum="21BD94039B6E3E13" modified="2019-05-08" version="1">MDDDYYSVESILAENQKVQCTFKVDIPDMGHLDGGNERDIKALSKAQIPMWMAYILIYSDHADFTIPPPFSSRVRNALKAEPCSVRLASLVGQAGMWYGFGRMIMRLLDDMSAQEISNVLVKTFQARLSEIVDQAQHFASIHAAAAASEGSGAIRIGGDTVTIGFREGLDVTERELFVLAQESARRMKRWYESSEKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB02</accession>
    <name>A0A401GB02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase I damage affected protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0205110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610226.1">
        <property type="nucleotide sequence ID" value="XM_027754425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB02"/>
    <dbReference type="STRING" id="139825.A0A401GB02"/>
    <dbReference type="GeneID" id="38776230"/>
    <dbReference type="InParanoid" id="A0A401GB02"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21449">
        <property type="entry name" value="DLC-like_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF7">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14567" checksum="42E01D666A4223EE" modified="2019-05-08" version="1">MASGLRSPTTPRSGAASPRQTFDVELLRAYMKKLLQTTLHNASWPEPRERDRIKAWMKEIGERVKERMLEIQPRGFKFIVMTQINENLGQGGRADMACHWEDSDAVAQEVFSNNSIICICIAFAVRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBB6</accession>
    <name>A0A401GBB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0206490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610362.1">
        <property type="nucleotide sequence ID" value="XM_027754561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBB6"/>
    <dbReference type="STRING" id="139825.A0A401GBB6"/>
    <dbReference type="GeneID" id="38776366"/>
    <dbReference type="InParanoid" id="A0A401GBB6"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="154"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="353" mass="39216" checksum="8E2B2F7E3D4BD52F" modified="2019-05-08" version="1">MAQDDSSSGAAVDRSTLRWISNEYYELNGLHFDVLHSPPTPLEFSRLVHIGRPVLIKNCEFSEDLSRWSDEYLVRKLGDGNISVAVTPNGRADAITAGPDGRLYFAEPHVQRMSMSAFLASLSSDSDQPQGPEQEEICYLQSQNGNLYTACYFNLSGDPDPSEFEPLREDVPSEIPWCSDALEKSPDAVNLWIGDSRSITSIHSDPYENIYTVVRGAKHFTLLPPTEGWCLEERTYPHAQYIRSPKTSPKTSELVLSPSPSTAVPIRWSSVVDPNLPGALPAEAHPIQISVQAGDALYLPAGWWHYVRQSSVTIALNYWYDLESRGMSWVWLNFLRGLGEPPSGNVEGKGVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBN4</accession>
    <name>A0A401GBN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0207840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610497.1">
        <property type="nucleotide sequence ID" value="XM_027754696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBN4"/>
    <dbReference type="STRING" id="139825.A0A401GBN4"/>
    <dbReference type="GeneID" id="38776501"/>
    <dbReference type="InParanoid" id="A0A401GBN4"/>
    <dbReference type="OrthoDB" id="3224367at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="261" mass="28271" checksum="09E53136DB0CB824" modified="2019-05-08" version="1">MASLFPPSGPTLPPFRTLLIQGPYHPTAPIHLVLSHTTENPSAKAILLSTSKKKLFSSLKESLDDWLATHGSDGRVCNSASRVNIHYPRSPAHLALLLSMLHTYNGAFYHPKTTIDSATSLLVLHELSAYFLLNNSEATVSSYLSLVSHALAAATTLSSDSSDVVLALFDSGLEQLKLPIIRPVSHDASDGNPPPIRSELVAGFVQRYFQWVGVVEVDIEVAHPAVSGRMVMITLRGGSEDEITWKWSESGDAGGVTFSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBV1</accession>
    <name>A0A401GBV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0208390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610552.1">
        <property type="nucleotide sequence ID" value="XM_027754751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBV1"/>
    <dbReference type="FunCoup" id="A0A401GBV1">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBV1"/>
    <dbReference type="GeneID" id="38776556"/>
    <dbReference type="InParanoid" id="A0A401GBV1"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019266473" evidence="6">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="112"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="143"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="422" mass="44804" checksum="116BB2FC27D6C0AE" modified="2019-05-08" version="1">MFAKASLIAFTTLALLASATPVERGLGVRIPLEKRASLTTDDGVFDLERAIQQSTRTHNKHRQNLINVHNNIGLENFNEGAKIMPLAEYHSPSGIEKRQKEPLTDESNDLDWAGPVSIGTPAQTFTIDFDTGSSDLWVPSSNCTSSVCSSKHKYTSSKSSTSSKKTGTFSIQYGDGSTVSGPVFTETVNVAGIKSTGQYFSPVTTLSSSFANDPIDGILGLAYPALSNLGHTPFFNNAKSQGSVSTGIFGFKLAKTGSELYLGGTDTSLYTGAPEYHAVNGSAFWQLTNAKTVVNGKIVNSGFQTIIDSGTTIMYGPPSAVQAFYASVPGASLNNAQYGYYQYPCASPPTVAFNWGGKNFTVSSANFNLGKVSSTSTYCIGALAGQNLGLGTNVWLLGDSYMKNVYSAFSFDNNSVGFATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBZ8</accession>
    <name>A0A401GBZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0208890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610602.1">
        <property type="nucleotide sequence ID" value="XM_027754801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBZ8"/>
    <dbReference type="STRING" id="139825.A0A401GBZ8"/>
    <dbReference type="GeneID" id="38776606"/>
    <dbReference type="InParanoid" id="A0A401GBZ8"/>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="5"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="168" mass="18513" checksum="B187199CABACD63E" modified="2019-05-08" version="1">MAPTSAIPTFYWIMFGCYEPMLTTMGFLGALANPKKIHDQQAPWPAGGPPGEIPLATQVTILQLAHVTLLLGFINIIVLSACRKYLSPYPALQEKIVRALLTPLLLGDFLHIGITLWALGDNRWDIAGWGGILWVTIITGFTLMVPRITWHMGVGRYVDSRDGLAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD30</accession>
    <name>A0A401GD30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0212630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610973.1">
        <property type="nucleotide sequence ID" value="XM_027755172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD30"/>
    <dbReference type="GeneID" id="38776977"/>
    <dbReference type="InParanoid" id="A0A401GD30"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="169" mass="18611" checksum="A8E5FA5949D0D982" modified="2019-05-08" version="1">MVQVQSEAASVGIILPLPRNIPVLAQVEIHLATARTVEASRWMVPRIADHLPAVIPRGLTARVLYDDPAVCEDFSLGHPLDGLPDIDVQSSCPHFPEIAFLSFAILPSGTLHLRVETLRNAARELYDVMRGITGRCELADGTLRQLRIIVEELEIAFGLVVFPRPITSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE19</accession>
    <name>A0A401GE19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0300960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611294.1">
        <property type="nucleotide sequence ID" value="XM_027755493.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GE19"/>
    <dbReference type="GeneID" id="38777298"/>
    <dbReference type="InParanoid" id="A0A401GE19"/>
    <dbReference type="OrthoDB" id="3192989at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="6">
        <location>
            <begin position="238"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="7">
        <location>
            <begin position="606"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1428" mass="160057" checksum="E9781D6E8084FAFA" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQLPEPAIHLIKMSNLSPMPLTDQIAGVLELMFRQKLYLTTHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPGQNEVLKAELERKWPPPFGESEIRIDQPATLVDMHGRILAWILPRVLIPDRQMKMLQATRALHPAIAASKPSSTTASWRHNPLYFLPPEKCAQFPVGSLCLSPGWFQQVREHMESGRLETSTSLKLEGGRSWLHDIYDSSALLGAILVIVHPTLYATGCQCLGLIQQDPELREMVLNWSSPFNALQVIANWETPFHRDSKTRYTFYNLLATLGNYTCAWLNFPTMHVAIDYSPGTIVAFCGKAIHHGVTRADGERLVYAYFIHNKSRLVVDLNDEVEFVTKVAKQTTRGVHYVDVPLPMPTGLNAPSPSKSPSKAPASGSLFNLDDGDILGNIGVPIQLDPAAQKTKTQNDFMRDWIPHRDDYLHAIVEMEAPPEPRNCAECKCAPFHQIEHWQGQYFEPASLYRVSICIHLGHGGDPCPLGTFTAHNNPALVVAPGSDFWNASNEDLNAHDGEVPDDGEVPFDFAPLAGTLDGEARQTDDAPDPTWEEDVPPVLSWPPRCDSYGNQIMVIIDISGIHHIGVDWCQCEMAVERDMQLLQMGLYPGTVKDPHTAFTFVVLDDFLLENKECKTAALNYYSKLKWVTSNAFPDTVPISVHMHSHGPTIHASSLPGPLSFSHDALHPVEKGGLAIFCPACPQPGLNLPFDWQADPVQWKFKHGFIMDGNFSAEHIKMKHPKEDVTLSDGQAFMVGQEDYKAHLAVAMESHQRSTCHEHRTVNQANVDRANLNATGIGATACARHGFFIPHTVVDFQKGERQMNMDYSLSNTLLTLTGITLVLIMYDIMCQYGVHVRKHFRHSAYLRMPFELKIDQGIGLFHVHGHQDCCFQRFSPNFIVGAGMVDGEVIETLWAPTNEVSGSTRGMTRAHCQEVLDNHMNDSNWKKTTRMMPTLMTKWKRVVLGFPQSKESFEALSASTDEEVLEAWQKEYNDTMEARQSDPKIMDTFDVQLRKAPGKDLTQLRLAGEESTKGLEKGTAGWLSTGLKIQEAQLKLANDIRKAGQNPSVAEDLKTLEHRQRLEVSILTFQRHSEKFMRRLEDVSAMEDHDNGALWDSLDENPFQIHPEDAEYGEDVIPPEQASLNLPSQIRFVAAVTNGLQTLAAQELELRKGLMNDILHELPMAFGLKSYLYCKRSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVRWEEGLHREMFTIRGICGDLALAGHADHIDHGGVIASILSICTFNREVLRPISIDIKAIPHPTTLVPRPKNLLEDSPDYWWKWDHQVGPVGSPMEAWWYKLGDPWEKVYTVSESTLVQLEQLHVRIVNLTSWLHERTDQKAVDQSLKNMPMAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEC0</accession>
    <name>A0A401GEC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0302440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611442.1">
        <property type="nucleotide sequence ID" value="XM_027755641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEC0"/>
    <dbReference type="STRING" id="139825.A0A401GEC0"/>
    <dbReference type="GeneID" id="38777446"/>
    <dbReference type="InParanoid" id="A0A401GEC0"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="286" mass="31665" checksum="632ED4C594C0D760" modified="2019-05-08" version="1">MRLIIREDPTAVGEYIGNYICKRINDFAPTPERPFVLGLPTGSSPIPTYKHLIKLVKEGKLSFKNVVTFNMDEYVGLPRDHPESYHTFMFRELFSHIDIPPAQVNILNGNVKNLIGECKAYEAKIKAMGGIELFLGGIGEDGHIAFNEPGSSLASRTRIKTLAYDTILANARFFNNDIAAVPRMALTVGVATVLDSREVVVVVTGQRKALALSQAIEHGVNHLWTLSALQLHPWGLIVVDEDATAELHVKTVKYFKSIERVQDEVEAMHAKLQAEGVEDDQVGSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEG1</accession>
    <name>A0A401GEG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611482.1">
        <property type="nucleotide sequence ID" value="XM_027755681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEG1"/>
    <dbReference type="GeneID" id="38777486"/>
    <dbReference type="InParanoid" id="A0A401GEG1"/>
    <dbReference type="OrthoDB" id="1161823at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="146" mass="15855" checksum="8936F9649E4E3A3F" modified="2019-05-08" version="1">MSAPKANTEPPKGVTIIRDLYRIASGSDKFRKVLWTGKHSQLVIMTIPVGGEIGEETHTVDQHLYFISGTAQAITDGNRKDHVKSGDTVIVPAGTLHNFKNTGPTPLIVSTVYAPAEHKADTVHDTLDQGEKLEDEGKDEPPTWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GET0</accession>
    <name>A0A401GET0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0304230</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611617.1">
        <property type="nucleotide sequence ID" value="XM_027755816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GET0"/>
    <dbReference type="FunCoup" id="A0A401GET0">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GET0"/>
    <dbReference type="GeneID" id="38777621"/>
    <dbReference type="InParanoid" id="A0A401GET0"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE80704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="32087" checksum="B646E55D59EEDF63" modified="2019-05-08" version="1">MAQITEGPNKTRPKRRGQPAVIKYYLVLYNLLSTLGWSYVLFATLTHFLTSAPPSSRLASYLPAFLTHSFPFLQTHRWEKYAPPELIPLFRRASSTYAAVGGVTAIVQSFAVLEIVHALLGWVRSSPLTTFSQVYSRLYVVWGVLHLFPHTRTNPLYASAVLSWSIAEVIRYAFYVCTLLGSEPYALLWVRYTAFLVLYPTGAGSEALLIFDSLPAAFTSPTVLRAVLGQVRGMSWPEVVHADFRAIMFCIWWPSLYMLYTHMMRQRRRVLGGGRTLGAKPKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF49</accession>
    <name>A0A401GF49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0305440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611737.1">
        <property type="nucleotide sequence ID" value="XM_027755936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF49"/>
    <dbReference type="STRING" id="139825.A0A401GF49"/>
    <dbReference type="GeneID" id="38777741"/>
    <dbReference type="InParanoid" id="A0A401GF49"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="160"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="527" mass="60889" checksum="CE266FBC48E6F7A1" modified="2019-05-08" version="1">MPYAQVHYPFENKELFEKTFPGDFVSEGIDQTRGWFYTLLVLSTHLFGRAPWKNLIVTGLVLAENGKKMSKSARNYPDPNLMFDKYGADATRMFLVNSPVVRGDNLRFREDGVREVVSRVLLPWLNSFRFFLGQVALLKKTSGIDFRYDPHAPVSGNVMDRWILARCQSLIYLVREEMAAYRLYTIIPSLLELIDDLTNWYIRLNRKRLKGEDGKQDTMAALNTLFETLLTLCKTMSLRSFIPEDPAAGDQRSIHFLSFPEVKQEYFDSEIEQRVRRMQAVIELTRNIRERHGLSLKTPLKELLVFHADMRYLSDVRSLQRYIQSELNVRNVIFTSDETVSGVRYRAVADWSVLGRKLRKDLGRVKKALPDVSSDEIKVYLKAGQITVDGIQLIAGDLVVQRYIKLPPTSEQQYDTHTDNDVVVRLDIQVHPELTGEWLVRELINRIQRLRKKASLQATDNVDIFYCFTEGKAVELVEAMAENAELITRTVGAMPADTREMKEKKESIVEEEQEVADMRFMLSLAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGS7</accession>
    <name>A0A401GGS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0310480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612234.1">
        <property type="nucleotide sequence ID" value="XM_027756433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGS7"/>
    <dbReference type="STRING" id="139825.A0A401GGS7"/>
    <dbReference type="GeneID" id="38778238"/>
    <dbReference type="InParanoid" id="A0A401GGS7"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1083"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="108"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="652"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1106" mass="124093" checksum="60991DC70B2553D4" modified="2019-05-08" version="1">MVYFPRHARRSSLLSRLNAALLRFKLVNWLRLIWLTTVLWDELGIFHLSLAFCKWPDDDLPQKETPTHVLLVSEPQVRYIPASKRTLIARLRNFFYELTLQKNWSSVIRLKPDLVVFLGDMINSVRALKTDTDYESQYRRFMDIFRLPPGVSAYYLPGNNDVGLNIDLADSRQARRQFSTHFGPLNQQVLVHNHTFVLIDASGLVEEDYQRAARNTEYDKWTAINGGPVHFVETLREQQVPWPVLFTHIPLYRPDTAACGLLRERGTIRRGVGPGYQNVLGKKTTNFLLQTIQPSIVFSGDDRDYCEYTHVPSLSAIMGDQRPTDIREVTVKSFSPYPTIRRPGFQLLSLISPPALTSLDPSVSTHSLSDTPCLLPNYIGVYTTHYLPLLLMSTVLLACARLHTFRGPALPIILDPLHSPSLSSPGVSPRSSFPNSATMRDVGQQGGLRTPRTPHMNTSAVHGNDDEGSISTFRACLVDDENPSPIDKDYPPYSPHYMIHNGERAQWTGGADTFPGPFRHDRVYRENDPNVASPALPDAPGRDSWRLLYHTGSFASPPLEAAELRKAMSINAQKAWNHPLGYSHGLMEGHVASTAAMRVTILHPYSLPVESLRIIWVGVIFYFELGTFKNHVSYCPWPDVDSTTSNTRSFTRVLVIADPQILDSRSYPGRNPWLMSLTQLLVDLNMRKSWQAALRLTPDAVIFLGDMMDGGRRAISHDEYEAYYKRFRDIFRTSQVLPTYYVPGNHDVGLGASSAFSESAVERYVTHFGKLNQEIEIGGHSCVLLGAPGFVEEEEERVRSGMGYTQWADARPEGTIAFVHAISTRERRNPRVLFTHVPLARPAGASCGPLRDRGTIRSGRGHGYQNTLSPEASTFLLQSLYPSLVLSGDDHDYCEYAHEIPAENVGSSSPVAVREATVRSFSMAMGVRRPGFQLLSLAPPAFSSSSQRTIADAPCLLPDQLGIYLTIYVPLLLTSLFILLVSNAHRVRTRRRFWTVWDVRDEPPDPDAWLSSATLDGRDDEEEKLITHATLPPPDSAFTQRPTRFSLGAAGLTALLQYVQEGVHRGRAESNAWRNRAGFVHGFVRDVAELAAMPLVIFVVITWWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGZ9</accession>
    <name>A0A401GGZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612318.1">
        <property type="nucleotide sequence ID" value="XM_027756517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGZ9"/>
    <dbReference type="GeneID" id="38778322"/>
    <dbReference type="InParanoid" id="A0A401GGZ9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="100" mass="10649" checksum="1BCC1428AA90B979" modified="2019-05-08" version="1">MPIASTLAADPPTVNLPLHAHHLGRHVGHGSFALGSLDYSVTETPDIFPAGPVGHAGRLRPNCTILIHTDRDRAPIHRNLSNERRCGAPVGVDLEIAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH04</accession>
    <name>A0A401GH04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0311300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612314.1">
        <property type="nucleotide sequence ID" value="XM_027756513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH04"/>
    <dbReference type="GeneID" id="38778318"/>
    <dbReference type="InParanoid" id="A0A401GH04"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="580" mass="61899" checksum="9FA57BF0A715C77F" modified="2019-05-08" version="1">MSNYASTSTWGHTTYPAYPSYPTHTYYDHPDVEAGSSPYEVSAVRSTLPGATPPPSPIQDRHHPLPDLPCRTIDSTPESQAPLPPSLSEHEVYPGVLESGLITANHPCVRDYLERFARYIQLSARAFEKQPEGMARVPKATIEGVKLMLGIKLNDLQCRAIYALGALKILPVGTRHDHACFWGTHNRKYTDEVILSVLRIPKPVIYHDRLYLGLAWNNFMLNSFADTYYPEVWGKEEKKKTGMTLRKRKAAPAPAPKEKAAPRAPKRPRTEVRKAVAPPGERMQTRSRARATTSMPPPPIPGASMPTAATAIPVSVPAPMPTLKEDVEDMEDVAVDVTGPVATAEPSRLTTPAIAPAPSPTPADVAVPTPADVPVPTPADAPAPIPADAPAPAPANAPSPIPTDAPASAPATTPAPVRRSSRQAARRAASSAIATPAVEVVETKPARARSGTVKSDASTTATAVSPSGSEETIVEVAVEGKKGRSKSKSVEKDAAEAAPAAKGTKRKAAPKKGAVKVQEEEPTRGKRKRGDTDTPVEPAEEEPVEDAPAPKKRARKAPQKPAADEVPAPKKRARTARTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH49</accession>
    <name>A0A401GH49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0312630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612447.1">
        <property type="nucleotide sequence ID" value="XM_027756646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH49"/>
    <dbReference type="STRING" id="139825.A0A401GH49"/>
    <dbReference type="GeneID" id="38778451"/>
    <dbReference type="InParanoid" id="A0A401GH49"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000016">
        <property type="entry name" value="Polyubiquitin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="156"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="232"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="308"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="384" mass="43170" checksum="74422A4891BB1B1F" modified="2019-05-08" version="1">MCRMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHA3</accession>
    <name>A0A401GHA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0312710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612455.1">
        <property type="nucleotide sequence ID" value="XM_027756654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHA3"/>
    <dbReference type="STRING" id="139825.A0A401GHA3"/>
    <dbReference type="GeneID" id="38778459"/>
    <dbReference type="InParanoid" id="A0A401GHA3"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28672" checksum="66876921430DB70D" modified="2019-05-08" version="1">MASSNLKILTKSHIIVAAKKRAKREQVKEVVFDDEARREFLTGFHKRKLQKKEDAKKKAQEREKKVRLEARREQRHMLAQRAALNAAETEKAYGGHIDDQDSETDWTGLANRSRNGARNETGQEEQYEYDEHVATVTVVEDFDPDDLIHGPDKAERTGDPTDDPSNSDGTILRTRHTRSSLGGNSRTKHTRPIERTKARIKNTVKSKDVKYQTSAARKAERMKQGRRKTEKAERAGGKASRRSETLRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHJ1</accession>
    <name>A0A401GHJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0400280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612570.1">
        <property type="nucleotide sequence ID" value="XM_027756769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHJ1"/>
    <dbReference type="FunCoup" id="A0A401GHJ1">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHJ1"/>
    <dbReference type="GeneID" id="38778574"/>
    <dbReference type="InParanoid" id="A0A401GHJ1"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE81657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="9342" checksum="18CF01A7A9A764B0" modified="2019-05-08" version="1">MQSFTQTRYDLHDQKISQVNKEEELGLAKNRKKFDIREEYYRLNAAQDQDWEPKRIERPKGLPEWGVPPTEPPSKPTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI09</accession>
    <name>A0A401GI09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0402030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612743.1">
        <property type="nucleotide sequence ID" value="XM_027756942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI09"/>
    <dbReference type="FunCoup" id="A0A401GI09">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI09"/>
    <dbReference type="GeneID" id="38778747"/>
    <dbReference type="InParanoid" id="A0A401GI09"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="126" mass="14266" checksum="B174403801E6FAEB" modified="2019-05-08" version="1">MSLLHALRRPPRLNICCVVRRAYTSKGEAPKNVGMKAETPVDGEESPAGTFSKSSCEPNTILDGLAYLKDQPPVIALPDEEYPEWLWTLLSPKVLEDDGPGGKAEKRRMRQENRKRIRDQNFMKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIC8</accession>
    <name>A0A401GIC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0402290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612768.1">
        <property type="nucleotide sequence ID" value="XM_027756967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIC8"/>
    <dbReference type="GeneID" id="38778772"/>
    <dbReference type="InParanoid" id="A0A401GIC8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12607" checksum="1CF92B9467C799F6" modified="2019-05-08" version="1">MSLPILSRSQLWWWVLTALECICAAFTRGYGRKIRPYSISTSGQTVPLSSLPIRHRWFLGDAHSIMCLTTIDELAGPVGLVYFPAMTERTVALPWRYAQSGMPARRNHVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIR2</accession>
    <name>A0A401GIR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 17">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0403770</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 17"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612914.1">
        <property type="nucleotide sequence ID" value="XM_027757113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIR2"/>
    <dbReference type="FunCoup" id="A0A401GIR2">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIR2"/>
    <dbReference type="GeneID" id="38778918"/>
    <dbReference type="InParanoid" id="A0A401GIR2"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE82001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="258" mass="28827" checksum="75C87D17DFF3525A" modified="2019-05-08" version="1">MAKKTSANSRRRPIDVVDAKVAVDLATAQTYSENVFLFVPNLIGYSRVVLAAMALHYMNYHPKYCTLAYTVSCLLDAFDGHAARALGQTSKFGAVLDMVTDRCTTSALLCYLASAYPAYAIVFQILISLDFSSHYMHMYSSLVTGSRSHKIVTSEVSRILWFYYNDPRVLFVICAGNELFYVALYLMKWVNTPLSTSLGLSVGYLEPYTWAEVMAMLCFPVCALKNVINVIQLWKASKILVGVDLAERAQAREDAKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJJ4</accession>
    <name>A0A401GJJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RWD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0407200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613249.1">
        <property type="nucleotide sequence ID" value="XM_027757448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJJ4"/>
    <dbReference type="FunCoup" id="A0A401GJJ4">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJJ4"/>
    <dbReference type="GeneID" id="38779253"/>
    <dbReference type="InParanoid" id="A0A401GJJ4"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="27645" checksum="D8E8F53C1E3A61B3" modified="2019-05-08" version="1">MSSEVLLEEFEVLESIYPDELSKLSERAIRIDIEPDEQVEGEEPLKLALEVQYSNDYPDVLPELSLEIVEGSVDEEEIQHLLNGLRAVGSENLGMAMTFTLVSQLRDQLLSLVQSRAKRRKEEEHEKERQALEVEEARTRGTPVTVESFNQWKATFDKEMTVRKARDDEEKSKALTAKEREEYKRLQTRLTGRQLFERNRDLDVSDDNLVEEGAVSVDISQYDRTLTEEEEEVTFSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJZ5</accession>
    <name>A0A401GJZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0408750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613404.1">
        <property type="nucleotide sequence ID" value="XM_027757603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJZ5"/>
    <dbReference type="FunCoup" id="A0A401GJZ5">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJZ5"/>
    <dbReference type="GeneID" id="38779408"/>
    <dbReference type="InParanoid" id="A0A401GJZ5"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="669"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="794" mass="87782" checksum="EAB6FD6A51DEA991" modified="2019-05-08" version="1">MQQEGTSSPSPRLCHRFNTLIWSCLDVDLYKSALFYAERYFVLDTNNHDARHLYATALLRSGQPHSAHFLVNLPTDIRCSGCFEIKAKCCTALGRHRQAREALEESMRGRAYTPAPSMSSRTVVSFPEEAVLHCRSGNMALKGNLPENAAVSFHKALALNPMLWEAFEGLCMLGRIPEIDELFPPRPPPIKQIPPDGAQTKVPIPVATGAGFFTPDVGGGGNLFRAWKPEISQPQPFRLDQALGSRDSIASADSSLFPEASFVQGSLRPSRSQPMVSLAVQPPAVRPLSSADEAGPVTKKLRSGVRQRTAPPSTNAADSNTNLKPSKSAGALLLGAADRMKSSKTTATSSRLHATGAKGGREQQPPVGAATRRSTRLLGGGNSKTLATKHSTLRDRRRVHTRVRSRSIESDMDEEPGGPLAFTPPPPIPQSPPEAPAGPSVPSAAQEQAAQDLYDAELADYHIYELMRSFARAGRAMALYDCHECLEHLEKLPSNHQRSAWVMAMVGKAHYELGEYVAAERAFEAVRNLEPYRLTDMEVYSTLLWHLQRNVKLSFLAQELLSTDPRSPQAWIAVGNCFSLLKERAQALTCFQRAAQLDPACAYAYTLSGHETIDQDLDKAINFFESALRADARHYNAWYGLGSCYMRMSKLRLADYHYRRAAQIHPQNAVLLGCVGMVHQRCGEHDKALKLFDEAVSLSPENALVRYRRAKVLISLRRYKLAVEDLEYLRDTSPEESNVIFQLAKVYRLLGDELKSAQTLAVARDVSPKSVNKIRKLLETVKDTRSEEEVMDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKA1</accession>
    <name>A0A401GKA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0409810</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613510.1">
        <property type="nucleotide sequence ID" value="XM_027757709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKA1"/>
    <dbReference type="STRING" id="139825.A0A401GKA1"/>
    <dbReference type="GeneID" id="38779514"/>
    <dbReference type="InParanoid" id="A0A401GKA1"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE82597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8931" checksum="BCA00C5463379E7B" modified="2019-05-08" version="1">MAGHGYTKHDPAIERWNSMRENAYKHFRFTPRTTWQSVCGLLLVPGAVLYLAAHEDCKWSWMGKLKNESLARVQPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKC5</accession>
    <name>A0A401GKC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0409780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613507.1">
        <property type="nucleotide sequence ID" value="XM_027757706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKC5"/>
    <dbReference type="GeneID" id="38779511"/>
    <dbReference type="InParanoid" id="A0A401GKC5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="194" mass="21516" checksum="D3BFACEE6DB441AB" modified="2019-05-08" version="1">MDASVILHKYTLAEALLRIEIFTEPFDLILWKAWAVRMHVLLVFMVQAQSKAASVGIILPLPHDIPVLAQVEIATARTMEASHRMVPQIADHLPAVIPRGLTACVLYDDPAVHEDFGLGHPPDGLPDIGTLRLRVETLRNAARELYDVMRGITGRCELADGTLRRLRITVEELEIAFGLVAFPPPITSFQLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKE4</accession>
    <name>A0A401GKE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613551.1">
        <property type="nucleotide sequence ID" value="XM_027757750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKE4"/>
    <dbReference type="GeneID" id="38779555"/>
    <dbReference type="InParanoid" id="A0A401GKE4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="179" mass="20345" checksum="06E7FCE3102439B2" modified="2019-05-08" version="1">MQSTKPFSKTHCQTASTENISPTNTGPILKQSPLGRTPIKRVRFSPSTTSLKGKWNDIPERTKRFARSSPQKASVARRHTFDVRGDKPQKADGCRVSVRECMISGPKKLLTREELERECAKRNRGNSRLDSDAIGPQFHVSRSGSFQRLLAQRLRVWPSSRRGDQKKAGEHFRRVSYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKG9</accession>
    <name>A0A401GKG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0410560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613584.1">
        <property type="nucleotide sequence ID" value="XM_027757783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKG9"/>
    <dbReference type="STRING" id="139825.A0A401GKG9"/>
    <dbReference type="GeneID" id="38779588"/>
    <dbReference type="InParanoid" id="A0A401GKG9"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="324" mass="36441" checksum="88CC9E8AF898379E" modified="2019-05-08" version="1">MSIIPAEGSSGWLELLIVQKCGVPSVRDFQLRHGMDLIRGKDLFLVIAPGQGKTTVMHAPLLAAQAQMKIGIALMIVPTKLLALQQETVANSHGIRALAINEDTMREAYHNNRDLLAELVSGEDIRLAIMSPQMLRSKRVRSLLSQQAVKSLVCWFFVDEAHLVDEQSGEWIEIFKSIKTMRTILSARTVWAAFTGMATPSRTLVLAENLGFQPGHYVNARYSVDCSNIKYIPRFFEHAVSGMDFLDISFLIPLEMASPTDITTTLIFCQTIELGYKIMSFLDRLIPEAVPYRNKIIKLYNSLMPATYRQHFVQDRLSGAELHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL27</accession>
    <name>A0A401GL27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0412530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613779.1">
        <property type="nucleotide sequence ID" value="XM_027757978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL27"/>
    <dbReference type="STRING" id="139825.A0A401GL27"/>
    <dbReference type="GeneID" id="38779783"/>
    <dbReference type="InParanoid" id="A0A401GL27"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37628" checksum="C03B5D92406DA1DA" modified="2019-05-08" version="1">MSERPLPTFDELPNFHNFPGCAWGIWGKDDQLGTVNLLTEEVVQEAAKEIKLGKTVCLNWPVNFPSNPAFGRQPPHHELWNKMEETHAINDDAIHINTQSGTQWDGLRHFGVLEHKVFYNNTPADSFPRGSFTMSDPNKVDPEVIKLGIHNWAQHGICGRGVFLDLVKYYTEDGSPLPYDPWSTHGIPVQDLEACAKKEGVTFKRGDILILRVGFIQRYYQLSSEQKESLIKEENWTFAGLEPSLEMKRFLWNNHFAAAASDQPTLESWPDPNGSPQLHQTLLGLWGMPIGEFFDVEALSKVCAETGRYTFFFSSWPLNVLGGVASPPNAAAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL69</accession>
    <name>A0A401GL69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0412870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613813.1">
        <property type="nucleotide sequence ID" value="XM_027758012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL69"/>
    <dbReference type="GeneID" id="38779817"/>
    <dbReference type="InParanoid" id="A0A401GL69"/>
    <dbReference type="OrthoDB" id="2651985at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="242" mass="27444" checksum="FF46D9F79DBD8E1B" modified="2019-05-08" version="1">MPAIPAWLRARFRQMSLYPPSLEASWYGPIDRLANLVFSDDHYMVKPQTKLRESVYAGEEPNDEEPDDEEPDDEETDDDESSDEGSDEEVHNAELWQEGLSTDSMGKVVQALSRDTKVYIPDFVVVLCDGIRDIPVMCIEVKKNDESQESSIIQLREYMSIIGGKDPHEDFVGMLVLGGRFYTFRFQITKEDDSEGEAQKQVTARRNPTPMGKGWDTAEKLEGAFLTVVKNVAKREKLEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLU8</accession>
    <name>A0A401GLU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0501870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614053.1">
        <property type="nucleotide sequence ID" value="XM_027758252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLU8"/>
    <dbReference type="STRING" id="139825.A0A401GLU8"/>
    <dbReference type="GeneID" id="38780057"/>
    <dbReference type="InParanoid" id="A0A401GLU8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="611"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="818"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="881" mass="94663" checksum="766AF419476CF6AC" modified="2019-05-08" version="1">MPSLAALPDELLIHRPTHWEQVPGLFPDTTQLLPMAVPGETNAASGSQVACLGRSFAQIAAEADSSVDDDEGDSFAHELNLTEDMHVANLNASSTVFQMGTHGGEGSKVSTKKSGKRKVKESSDKEEVPTVKLPKKKCATKEYKSKEFIESEDETLAPPSNLPAKTAGDSNAGVVKMNAPAKPVRQTTGMTVSPHVAPKVKVKVTVSQKDMWKKTSTRVSDFMWAHATDLLVPCIGCKEKGWPCKLHTTNFSQCLEGAARGISYSIAPRNRDGMPLRENSHTTQREFQEMCAALVLECKLLPMSPPPYDVHVDSDEPDSAEPLVIEASKCKLPKKTKTCNAATSSSKVKGGEEVEVMKQKVTVTPDEANAEDKASVEKLLKFKRPTKSATVTGAVAPSNSGEVTNSGEVSKSGAPAKSGAVTKPGEGKKSGPKPKPVRSQNSGAQDGGEVTRTSVHEADEVLPAKSVAKEGEQTTRVAMGGRSGPMVPVITRKAKASAPKAAAKMPLAEGDGMEEAARLAMEAVQAMAFQTGPAVPPQASSSKRMLTPVANESEDAPEYQAEVAEDEHVSLERPHDDRQCSLLMPHEMSAGAAEVAQEVTPCLEISKASKGAKSSALAKAGHVDEGRRPAKKGTTLDHKAAKKEAKANHLRAVPPTSKAPHLRDIHGEETSQSSNNDCVNCAELQQEFLAHKDGMEVQFQERMADLNTVKAEITAALQRINLPFALQENAWSICEEVKLVMEEFHRPVTIELQESVKLAVADLVAKRHCLPELKEKVNRLEQGVNQTVSQVNVEKLQGELADLRHSMELQAAWSDSMEKKLRSSVAEAIAQASKLEMELALAKEDSMAVATSTLDKVKKVGKEVATVREETSLVVKSLDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM43</accession>
    <name>A0A401GM43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0503040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614169.1">
        <property type="nucleotide sequence ID" value="XM_027758368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM43"/>
    <dbReference type="STRING" id="139825.A0A401GM43"/>
    <dbReference type="GeneID" id="38780173"/>
    <dbReference type="InParanoid" id="A0A401GM43"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="374" mass="41968" checksum="09290721034053EF" modified="2019-05-08" version="1">MEPLQFKGEVMDFDLEFDGDHRKRRRNRTTQSCLNCHTSKRKCDRKRPCQRCIQLGLTGLCVYEVDDPALRDDPNVDETTRLRNRIAELESLVRELRGKPHPRWAEPSFCEGDANEKWHSRSSKRGQPQYQKMRPDGVDERVHASSVASSTSTLVKAEQTVNPSHQQFYRLPPSSSSAYPNTGHLLPQTFSRDRQQSPTDDLCYTSSTSAVTYGDHRHSDAATTSHCDQYGQQPYSRSMTVESESMQPSCSCLTNPAAGLPLIALTNQLRSALGILRQLPEHNTHHQCIILRRIMELDDLMHGNSPGAVSGSSYDALPTPTETEILSPISTSSHSSMGNAMQEWPTMSTSSGYDSYFSVPQGQHGTYQKSYHMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMI0</accession>
    <name>A0A401GMI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614303.1">
        <property type="nucleotide sequence ID" value="XM_027758502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMI0"/>
    <dbReference type="GeneID" id="38780307"/>
    <dbReference type="InParanoid" id="A0A401GMI0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18974" checksum="24BC4EEA1009E5DC" modified="2019-05-08" version="1">MPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDSNAMDVDRVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFYPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMM2</accession>
    <name>A0A401GMM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0505120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614376.1">
        <property type="nucleotide sequence ID" value="XM_027758575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMM2"/>
    <dbReference type="GeneID" id="38780380"/>
    <dbReference type="InParanoid" id="A0A401GMM2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="126" mass="13366" checksum="C774775E738F4651" modified="2019-05-08" version="1">MDESIGSCFGACCAICTSSALEQWCFSNKCGTRGNGSSGCCGSCFDRSFDHDEFAEERRAGKAVGVAVDVQPSPKNGMEVARRSSDFAVPAEGGGTGKEAKDDEEGRRPRLDHARATLLHGTSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNJ0</accession>
    <name>A0A401GNJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0508390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614696.1">
        <property type="nucleotide sequence ID" value="XM_027758895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNJ0"/>
    <dbReference type="STRING" id="139825.A0A401GNJ0"/>
    <dbReference type="GeneID" id="38780700"/>
    <dbReference type="InParanoid" id="A0A401GNJ0"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="107"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="246"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="463" mass="49990" checksum="21019F8178758CA0" modified="2019-05-08" version="1">MTSTPNPVFKFNRDTYTVKVENIVEYVSRHDIVELFSNLIGEVRKCEEHTEGSRRALFLTFHTNDAAKKALCMSGYNVAEVPLTVTASIAPDFPRVVKHSRQQDMRRNLYVLGLPFDLTKAEFVDLFSRYGTVSHAVILATVDNASRRRGFVVMSNHEEAKRAMDALSRTDIKGHQIDVSWAVVQRSQGFLDGGDRMTVLSSHSPSPSPPFDIGSVHSAPSSGAVSLATTPLPEQVPLPILSAHAAKILVTNLPAVIFSQTADLLPLLCPFGEIKSLEIVPCSSVDVTQGDISVVIEYATIAQAKEACDALHGQMYSNKPVKVEYLPPTGSDFNTGTGLSEDFAKTGLNPHAAPFMIPATLPPDAVLASVGPLYTEPNGQAHIAAAVPTGLLAVNSYHLSPYATSPSLYTHVYVPVAGTVRPNSAPSLWSGNPLQSRAGQWTFPHLQHLSNLSTPSLRSPYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNP5</accession>
    <name>A0A401GNP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0508900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614746.1">
        <property type="nucleotide sequence ID" value="XM_027758945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNP5"/>
    <dbReference type="GeneID" id="38780750"/>
    <dbReference type="InParanoid" id="A0A401GNP5"/>
    <dbReference type="OrthoDB" id="2590620at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="219" mass="22392" checksum="DEE723CFFCA187A5" modified="2019-05-08" version="1">MGIFGKNNNKKQADANPTNPINPANVGQTGQYDNAGTGQYDNAGSGVGNQAPTDNTQPGPRHHHHHQHGGGGGGDLNTRDYAGGPNTGYGAGGNQGNIGGYNAVSDPHNQPVGQSSVPPAGAINDGPRSSGGGGRTVGRVEQAVGSMVGSQALKEKGLLKEQEAGAFKAQSAEIGEAERLEREAVMRRERAVAHGAHPDNKYLGGRQGGPTGGSREEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNQ9</accession>
    <name>A0A401GNQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614297.1">
        <property type="nucleotide sequence ID" value="XM_027758496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNQ9"/>
    <dbReference type="STRING" id="139825.A0A401GNQ9"/>
    <dbReference type="GeneID" id="38780301"/>
    <dbReference type="InParanoid" id="A0A401GNQ9"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="360" mass="40573" checksum="840FE89AD37D1498" modified="2019-05-08" version="1">MVGPAPTSPQTYLQIIGACDNFRVSGTSTNASNEHLTPWHLTPEPFSPAIGLLRPVVLSQLRAENARGQPVWEFSTHGGQATVSFATWIRTSAQRTRVMKEMCERWRDEDLWTDIIGPKKWRGELYPVYRNPFGAHDSPAKDEDALDTSGAMTGDTAKNYAFMMERAACALFGVVTYGVHMTIYEDDVDADGARSCKIWVPTRSRTKQTWPGYLDNSVAGGIPCGLGAFESLVKESMEEASIEENVVRKYVRSVGSVSYFFRTDAGWLQPEVEYVYDLRVPPGVDPAPFQPKPLDGEVELFELLPLDEVITRMRSGLFKRNCALVLVEFMIRHGYLTLEAEPEFLEIITRLHGRFDYDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP80</accession>
    <name>A0A401GP80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614948.1">
        <property type="nucleotide sequence ID" value="XM_027759147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP80"/>
    <dbReference type="GeneID" id="38780952"/>
    <dbReference type="InParanoid" id="A0A401GP80"/>
    <dbReference type="OrthoDB" id="2803071at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="380" mass="42456" checksum="94AA8518312B371E" modified="2019-05-08" version="1">MATSSSLTVFTQFDDLPVVTLPDDRFFVDTYPRTSQEFSAFCDQLKQEANAWQDQETCSVDIVHRWCPSALPCLGCAASSRDRRPVPGTVRHRAFVDSNSKITLSLTRPLRIGPNEWSQVWRGTMNVSSIGSEVLPPVSAVVKIFQQSFFEQPESYAPESGIMFATWLTGAQQARREAWAYSLMQSLQGGEIPWSYGIFKLRLGHGELAFAHVMEFVNGRSCTQISVSDSPQAQVWALASSMASALYKTIQCGVRHGDVRSSNIIIRQDAAHPVIFLDFAFAQPILPDRFSGDLNGLVFTLQAIGMAIPEIKAWFEDGIQRQAPWSELFVHQINTVPLWWSSFEGVVPSAVLEYCSRSIRGWNSPEGDFEDLFPEVEDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPQ4</accession>
    <name>A0A401GPQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0601180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615053.1">
        <property type="nucleotide sequence ID" value="XM_027759252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPQ4"/>
    <dbReference type="STRING" id="139825.A0A401GPQ4"/>
    <dbReference type="GeneID" id="38781057"/>
    <dbReference type="InParanoid" id="A0A401GPQ4"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="221" mass="24524" checksum="B65D3A913CB34E08" modified="2019-05-08" version="1">MARVLRCQRGADFPHWWAHDLPHIKSQHKPQNGPPSLALHIHHVPPASTSQRRTDPRRLFTRVISPPAPASMSALARPLARPPPVFTAAPVPSPTSAAEWKHEPSTLAVLFGLRLPYRPPRSPAAAFLWRRRLWFETTFALSMIQPWEKVLVLLISYATLLFVLLAAYAYLPAHLTYLRARAAYYLLGAEPDPRLASAWGAVAGFVADWNASVAPAAVSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPT1</accession>
    <name>A0A401GPT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0601370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615072.1">
        <property type="nucleotide sequence ID" value="XM_027759271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPT1"/>
    <dbReference type="STRING" id="139825.A0A401GPT1"/>
    <dbReference type="GeneID" id="38781076"/>
    <dbReference type="InParanoid" id="A0A401GPT1"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="82" mass="9769" checksum="1096C6AE9AF8A2BA" modified="2019-05-08" version="1">MKDSAISHFRTLLESYFGAGWKELMRYDEYSTREYMKFVNPKYSDRLMNYLETFTSALNLYDCAPTETVIDSLDFEYCTNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRG3</accession>
    <name>A0A401GRG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2OGFeDO JBP1/TET oxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0607200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615653.1">
        <property type="nucleotide sequence ID" value="XM_027759852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRG3"/>
    <dbReference type="GeneID" id="38781657"/>
    <dbReference type="InParanoid" id="A0A401GRG3"/>
    <dbReference type="OrthoDB" id="3200752at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="117" mass="13155" checksum="737998C7F29EBB47" modified="2019-05-08" version="1">MESGRLETSASLKLEGGRSWLRDIHDSSALLGAILAVVHPTLYAAGCQCLGLIQQDPELREMALNWSSPFNALQVIANRETPFHRDSKTRYTFYDLLATLGNYHLRVVEVPHHACRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRN1</accession>
    <name>A0A401GRN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="19">CPR</shortName>
            <shortName evidence="19">P450R</shortName>
            <ecNumber evidence="19">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SCP_0700460</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="19">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="19">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Endoplasmic reticulum membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Mitochondrion outer membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="19"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615779.1">
        <property type="nucleotide sequence ID" value="XM_027759978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRN1"/>
    <dbReference type="FunCoup" id="A0A401GRN1">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRN1"/>
    <dbReference type="GeneID" id="38781783"/>
    <dbReference type="InParanoid" id="A0A401GRN1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 19" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 19" id="KW-0274">FAD</keyword>
    <keyword evidence="3 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 19" id="KW-0288">FMN</keyword>
    <keyword evidence="2 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 19" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 19" id="KW-0521">NADP</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="20">
        <location>
            <begin position="65"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="268"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="455"/>
            <end position="458"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="473"/>
            <end position="475"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="494"/>
            <end position="497"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="645"/>
            <end position="646"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="655"/>
            <end position="659"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="731"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GBE84866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="732" mass="81213" checksum="8680F35BA9D73AC3" modified="2019-05-08" version="1">MAFTSSSDAVVLAIGLVLAAVYLFRDQLFAVSKPKAVPITSKATSNGSGNPRDFVEKMKQGKKRIVIFYGSQTGTAEEYAIRLAKEAKTKFGLASLVCDPEEYDFEKLDQIPEDCCAFFVMATYGEGEPTDNAVQLCENLSDESFEFSNGERKLPGLKYVVFGLGNRTYEHYNLIARNVDRDLQKLGATRIGERGEGDDDKSMEEDYLEWKDGMWEAFAKEMNVEEGQGGDTPDFAVTEVEDHPPEKVYLGELSARALTRSKGIHDAKNPYPAPIIIARELFENQADRNCIHVEFNTEGSGITYQHGDHVGIWPSNSESEVQRLLCALGLYEKKDKVINIDSLDPALAKVPFPVPTTYITVLRHYIDISAVAGRQILGVLSKFAPTPEAESFLKTLNTNKEAYSKIVGDGCLKLGEVLQLAADNDLGAVPTPENTTAWKIPFDIIVSSIPRLQPRYYSISSSPKLHSNSIHVTVVVLTYESVASEKVKSKWVYGVGSNFLLNLKFAATGEEFLAITDPDGPKPAVVTTPQYAVEGPRGAYKLETLYKAPIHVRRSTFRLPTNPKSPVIMIGPGTGVAPFRGFVQERVAMARRTIEKNGVEGLADWGSIRLYFGCRRSDQDFLYKDEWSDYSKELHGKFTMRCAFSREVYKPDGSKIYVQDLLWEDHEQIADAILNGKGYIYVCGDAKSMSKAVEETLCKILGEAKGGRAEVEGAAEVKLLKERSRMLSDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRQ8</accession>
    <name>A0A401GRQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0701130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615844.1">
        <property type="nucleotide sequence ID" value="XM_027760043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRQ8"/>
    <dbReference type="FunCoup" id="A0A401GRQ8">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRQ8"/>
    <dbReference type="GeneID" id="38781848"/>
    <dbReference type="InParanoid" id="A0A401GRQ8"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="462"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE84931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="559" mass="60370" checksum="6AFC7DD45E2CDEAE" modified="2019-05-08" version="1">MGQTLSTPVTQKKTEDGGNDKFYYAVSEMQGWRIEMEDAHTIALSLDQDDDESNTFFAVYDGHGGASVAKYAGEHVHKKLLADGAYLKKEYATALKNAFLGTDADMRASSTFTRDTSGCTAVAALVTSDERIYVANAGDSRSVISVKGEAKPLSYDHKPQNEIERSRILAAGGYIEFGRVNGNLALARALGDFEYKKNASLAPEKQIITSDPEVIAHEITDEDEFLVIACDGIWDCLTSQQAVNVIRLLIARGKTIPEICEEICELCLAPDTDGRGGIGCDNMTILIVAILHGRTLQEWYGWVTNRVKHKHGFATPDQIPQLYSTSALIAFRARREAYEARQREREAYRNASSTRPDTQGFGGNTIDGVEVGGSSFRDFARILGSTGGITYNPATGELKRRLVFDDVDVDDDDDDSGDEYVDADETNGVTSFTGVSFNGTFGLPHSDGSDITKSLREQLDELEEAEADSACPESDDMQMGEIDDEVTISGMETAPPTAATPAKQQDSGGLQGEAPPPPKLLQNGDARPKQLVSSPAGDAPSAAVQAEGFLDSSESPLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRY9</accession>
    <name>A0A401GRY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0701110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615842.1">
        <property type="nucleotide sequence ID" value="XM_027760041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRY9"/>
    <dbReference type="STRING" id="139825.A0A401GRY9"/>
    <dbReference type="GeneID" id="38781846"/>
    <dbReference type="InParanoid" id="A0A401GRY9"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="219" mass="24288" checksum="1FD16D48AEAF51F3" modified="2019-05-08" version="1">MQQHPVPPPLDSSDLITLASDWRAGFFDAIFESFDAGEESPDIDVVHARVLDKLLQDRDVGTDVWDAAVREHLVRSWHVQAAWPDSIQGLTRLKDPCVVVVLANGTTRLQLDIIRSARLPFDTLFSSQLLQATKPNPAIYLKALDLMALHPEQTAMVAAHAYDLRAAAKIGMKTVYVQRSTEDPNEDMEAIRAEVDLFISGLDEGEGLLELAALMNFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT27</accession>
    <name>A0A401GT27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0705620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616288.1">
        <property type="nucleotide sequence ID" value="XM_027760487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT27"/>
    <dbReference type="STRING" id="139825.A0A401GT27"/>
    <dbReference type="GeneID" id="38782292"/>
    <dbReference type="InParanoid" id="A0A401GT27"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="587"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="946" mass="104571" checksum="BD06012BECA20A04" modified="2019-05-08" version="1">MSAIGNQGNRGGRGGHGRGRGRGSPATSIAGSDAGLGGRGGGSGNPRGQTLSGRGGGFIGRPSRASFTRGFDTRGRGTGGEGKQLNVRDEMPMRPGWGTLGTEMKVRVNSFAVKILKNIVYDYHVAITPYKVGAGRRARIFQILESNPIYAPHVRYIAHDSSQRLVSATKLPQPLSIPVPYVEEGQTAPLPNALVFTVEIRLIRELDMRELNAYMDGQPDHSDDDTGPMISALNLILQQHAASHGTRVGKNRYFFPSSGLYPLGPGLEAYRGFFMSVRPTYKQLTVNVNVCMTAFYTPGNLADAMIAFNGSTGGMPGSFTRGLKVSTRYLGYTRKRTVMGIMSTTARQMRFQCDELNGVVTMEEYFQRRYGIHLDHAHDLPVINVSGMTCLPAELCEILPNQPYRGRLGNRENAEMTKYACNPPDTNAEIIVSQGFPALGLRWYAQGVPLQGFRITLNPEMVTVPSRVLPAPRITYRSGNCAVHDGSWNILNVKFHVGSDLRNWAVLLVQDGGDEEFTGTNDPALQQFIEMFAAKCRSSGMNVPTLPTSIATSRLPHPRDDPSRTQALEQIRKAITQNLDRNNKPSFVLVLLSKIDSYIYPGIKKLCDTVLGIHTVHMQLKKARGNNQDQYFSNVALKVNAKLGGTNHLLDPQSMRWLTEKRTMLVGISLTDPGPTSKLCALSIVAVVASVDSDFVQFPASLQPQKSNLNKGAKEMVEKLDDLMVERLLLYQKKNKSLPERIFVYRNGVSEGEYNLVLQHELPKLLVAFKKVSPEALYRPKLTITVCGKTRRARIIPMDYNVMDHKGNTQPGTVIDKGITNVYSNDFYLQAHPGLQGHARPKHYVVIYDEQHWSADQIQQGTHTTSYGYVCATKAVSLVPPAYYATLACKRGRSYINSILDAGEDKTSTMGGRETLEEQTQQVDDRAMKFWGNGVHVDLKESMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT68</accession>
    <name>A0A401GT68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616320.1">
        <property type="nucleotide sequence ID" value="XM_027760519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT68"/>
    <dbReference type="GeneID" id="38782324"/>
    <dbReference type="InParanoid" id="A0A401GT68"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="59" mass="6068" checksum="2F10CA12B625F82D" modified="2019-05-08" version="1">MVQDKPGTGEGKTATVTTTSLQPLHMPATPASISIIANMTTIAQPLAPSQIDSMPPHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT90</accession>
    <name>A0A401GT90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0706220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616348.1">
        <property type="nucleotide sequence ID" value="XM_027760547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT90"/>
    <dbReference type="GeneID" id="38782352"/>
    <dbReference type="InParanoid" id="A0A401GT90"/>
    <dbReference type="OrthoDB" id="2758729at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="328" mass="36092" checksum="8BAC4314E6FACB09" modified="2019-05-08" version="1">MTESSGFNTFGFVASILSVAALLGPVFGVIYFYLPSRRQKYLDELLCETEGLWRTAVEEGLFTGSPFMKKTEQTLAHYRSQASHLRVRTYYATTLYRQVKGTVTGLSLKLVYLCREVTELRATITTTTTEERKRLQNEGHYNPLGSQSIARPAGKTANPRNSFDEVACSSSESAPHIDGTDNKDCPHRPGSLAIAPTEDESSSLASLDSEDFESRHTSSATVNVEEVPIQVVEKDLGVIRPSLCAESNQENDAAPQQHLPPTDSTLYKILDRVYHDLSAEGQSHPLLSAAAQYTRAPHTIDLESLLQEYEGDASMTPSGSLKVQTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTG9</accession>
    <name>A0A401GTG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0706600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616386.1">
        <property type="nucleotide sequence ID" value="XM_027760585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTG9"/>
    <dbReference type="GeneID" id="38782390"/>
    <dbReference type="InParanoid" id="A0A401GTG9"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="523"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="865" mass="97116" checksum="3D14AA60598C8263" modified="2019-05-08" version="1">MSSPRSRAPSAPTLHADVSSPPTPHSLTSDWTPLVGEENAKPENLRRSDDDNEPHADRAEGFILGPMPVEVFLDSLPAKHTARRPPTQGAFDDVDEPSRLFAAIRDHDCCPGFKFKHNAPDLTLTKPALVGGCSAPSPAAPSPGSPSPRQAATGRTCVARATASGRGRSPWPLPCPSMNSSPAYFAAASSSDPITRAALCKLVEERRDLMTLYLADCLFDDLQKVDELISMFPCELRGCLDAISSRLPLRERTRRIGNNIHVSVSYYVIGMLPMHRCTNVGCTTSQVPIHGLRARLMRWDMSGLRFAHASTVERGYDPTVERASSGEECLFRQLVSCRVREQLDLKPVEVPEEKVKDEVREEYKARIPRPVALTICAEDGRLKRCLVSRPIATNFSMRWGVMRGYRAVMGGRVVFMEDTWRQYVHEPEGRILKELAAHRVKNIPHVEHDGDVPKVVYSDGTGRVGVVLPTGEARGTVRVLVEICARVLGRARIQPDGGAGIERRGVQWKFRQRMSITRPAALTICAEDGRFKCCFVSRPITTNFSMRRGGMRGYWAVMGSRVVFLEDTWWQYVHEPEGRILKELAAHRVKNIPHVEHGGDVPKVVYSDRMLTRFSAMANFERTTRSKTGQQPSFQCTEMDLYSTALPRSATSMSNSSVSSFSIPVHQDGLILLHRLAQKAKWLYYGGPRIVVHPRVHHHLNLKKVGFPLQTMRGTKELLNAMHDAFQALVAVHDKARRIHRDISAGYLIDSSKVQEDEQATDKYIVGTRMFLSQRLEAQSRRRQMLQDDMEALLYVVAYCGLHWLQHPAHSKDTRQAMMEPGKGKLDNKENQTYIDPPNFNVDLKDWLSHSMDLNHPRRPSEATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUG4</accession>
    <name>A0A401GUG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0803970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616788.1">
        <property type="nucleotide sequence ID" value="XM_027760987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUG4"/>
    <dbReference type="STRING" id="139825.A0A401GUG4"/>
    <dbReference type="GeneID" id="38782792"/>
    <dbReference type="InParanoid" id="A0A401GUG4"/>
    <dbReference type="OrthoDB" id="3267359at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="471" mass="51787" checksum="3159E9CFBEAED83A" modified="2019-05-08" version="1">MQDARSSRAKRAPNRWNAYLSAELKRFNAALPSGQTAYKSNSLPFEIKAKWDAMSPEERITITDPLLKNLQDQRETKQLAVQNVPINAFHDVRSNLASVQEQLEALHARTGTEILMIAVRSSNDHYNRPHVFFTSDRLSDFFTVVLRTQLADVAMQMESYCLSGIQGLVSRSRDQVAELKARINKMIYDKLRAAAEVEVPRMYYTNFEKKITEKHAVVIEGWPLGKFCPPSDLRSRTELEVLYKAWETSETRFHKMSRAKYETWDDSRFRAALENGHDNDELPVPVTAVSLRAPNWHIHRGLIHAGGARVVPDGVPTHSQALLGSPVVTSTVVTSTAVTSTASTTRKRPADAAANSSNKRRKQGPFQDFINVVSGVGGELVAVTKKPRATRKDKGVPRKKKAKGPTNDENGMPSSGNAPANIVPAHALPSATAVTMNSALSSGDTHVISTAAVYASPSAMATTNTTPVSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUI8</accession>
    <name>A0A401GUI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import receptor subunit tom70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0803720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616763.1">
        <property type="nucleotide sequence ID" value="XM_027760962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUI8"/>
    <dbReference type="FunCoup" id="A0A401GUI8">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUI8"/>
    <dbReference type="GeneID" id="38782767"/>
    <dbReference type="InParanoid" id="A0A401GUI8"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE85850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="595" mass="66408" checksum="9AC55F9B4910FA79" modified="2019-05-08" version="1">MSSSTSQGVVDRVQHFVSENKRTLIIGTAAIVVAIGGVAYLASTSRSSQGDAEKGERKKDKKKSSKKRKTVKDQDGPILEERSPKVAEEETEELKLTAEQIAQMSTEERSKAAASLKAKGNQAYQQRKFSTAIDLYTRAIEVTPKPEPVFFSNRAACYVNISPPQHEKVIEDCDEALKLDSNYVKALNRRATALEALEQFEGALRDYTAATILDKFQNESAAQSVERVLKKLSSKKATDILSTRVQRLPSHTFVSAYFGAFRSRSLPVLPENLSTGDNTLILSLQALTAGDYIHSLSLVNEAIEQGISWNEGKAEALNLRGTYKFLMTDVVGAKEDFLASIDLQPSLTQTWVKIASVYMEQGDPKKAFECFEEAIKHNADDPDIYYHRGQVLFIMNEFTEAAQNYTKSTELDDQFVFSHIQLAVAQYKAGNLVNSMATFRRTLKAFPGRSEPQNYYGELLLDQQRFQDAVEKFDRAIELENSKPPPINALPQVNKGLALYQWKQDIGAAERCCQEALRIDPECEAAVATLAQLSLQQGKIDVAMDMFERQADLARSEPELMNALTYQFATAAQVEFMKNYPAMAGQLNQMARNMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV93</accession>
    <name>A0A401GV93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0801840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616577.1">
        <property type="nucleotide sequence ID" value="XM_027760776.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GV93"/>
    <dbReference type="GeneID" id="38782581"/>
    <dbReference type="InParanoid" id="A0A401GV93"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="159"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1416"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1500" mass="163695" checksum="7157B73873F116EF" modified="2019-05-08" version="1">MMDASSHPRTRGLRINGASGGSRSQSKNRKWVAGEPSGSGSHSSNGERWERGGHRKARGASRGNRPGRTPTPPSANTAIHEDAADITDDDRSGEDELDDEEHRTHEPQTLEERERFYQELVKARDSERNRAIAEGKMDDPTVSKRLDEAITIVGTCMDMCPRFERYRRERENNLDRWEVVPGTKRVDHKRAVKIYERGAGDKSIPSDIRPPPVLKTTLDYLFHDLLMRGGFAETHDFIRDRSRAVRNDFTLQHDKGPIAIECHDRCARFHILALHLERDNPRFSIALEEQQLMNTLQTLKECYEDQRGNYQAPTELEMRVYHRLIHIRDQRERHEEIPQEITSHPVFLYTTQFRLHVQAKSSPISKTSTLVVDAEAMQIFGQLVTVLREQNNVVMVYLVACILERLFGKDTIEDIEAIRGAMSIPDIIDGISQPLTGNDAEAEAYISDEDAVEPALPPPIDSAGGIFASAANTSRPQSVFGRASATTAAETPRPVVSAFGNLKTTPNAFGTASVFGGSVLSSSAPKSVFGSATFPTSSSPATSVSAPQLSSTVFGASSSAPANVSPSPTSGGFGKSAFPPASSSSTLKSSTSAPFSRLSGSLLTAPPPIARSSKIFGPPLFATGVASAPTAPTVPQPPETPHLNPFASSFTPSTSSLLFSNIPTTTPSIPPPTAPTPQAAPTFITPTPPAVSAFGIPSPPILPASTTSTPVVAAFGTTIPPTLPAFDATSSTQATPPFNAPPPNFFGSSSLPVLATSPSAPPTLPPPSSSTPSVPPESAPLSAGNNVPATPKIIERSQTLWEIPSSASPLRLPTGITTSTPGAAIPHAEPEPESPIAPPPVDTFRPISLPPTPTARWFDPSSQSKLTALSKKRSLLGFALQIPEGTSSTMLSPLPLPSPGVSKVYQELNVSPSQQRISPSSSFSSAQSLAKPASQTNFQVNGHVSAMVEDKEVLAHLTPLALHFLRKSRLVKRLFKVWKKRTTDTALWEEAVLRSEAYTAKVRRERLARGQSSPSTNGKEPNKRRRASGGGSPETSPFKRAKRRVSARFEERLTDDQLAQRLQENHEEHRRRWEKGSFLRTVRMRLKGASPRGLPSPEWRLWLTMNPENDRTAIWLEHKFDVPASGVWESENTFSIQGSTAVQDPPSHGSPGLIVFERTPLEGITDELERKIRILDDCARLREVIGNLPQSNGLRFVPSLLVIVWTEEERTKPEVTRDFEDMTAKLAEDGVIKCVSTFSISSTSTDLDRKFNEFVAAVPLDVKDKLSVSLSWKDVSQVFLASFRTMASDWLDSCWAHETFVWPRYQHVLRAMEESLNHIIRSIIRLFGLTADVSLKIPAELQVPPNIGTGYAMGPFLDAHARLAIATAAEVLGERRSSACVVPKALVEALRSEIERHLQAHDDHLRELSIASLPISSRTSPKRRATDDVTVDSPPPRSKRMRSSSYSGNVEDAQDGVTASLPPRTSRSTADIADRAEKPVITAAMLRALTQDVFKTYGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVA8</accession>
    <name>A0A401GVA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617071.1">
        <property type="nucleotide sequence ID" value="XM_027761270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVA8"/>
    <dbReference type="STRING" id="139825.A0A401GVA8"/>
    <dbReference type="GeneID" id="38783075"/>
    <dbReference type="InParanoid" id="A0A401GVA8"/>
    <dbReference type="OrthoDB" id="2803957at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="470" mass="53292" checksum="01DC0A76294236CF" modified="2019-05-08" version="1">MGRSNPKKQSPSRRNPVSSVKMPSRYPPSSNSSQKTYCLHEVVPPKKKSTKASQPAHKKWVAPANDTSNEEEREVEGEYDIESEDEDEKEDEDQDEGEKEDEDQDEGKKEDEDQEEGEKEDTEPHRHHKRGNAALDDKTDTTVFHPLKAYHDGTRFIPCIIGPFARPMQALQLGLLLQQDDDDELDPQTKDTFSSMDDDEREELIYTFDTLLSFIPGLKDQLLNHYAPDARGDHLGSLRERIINYLPDFGAEYPAMKPQDSKWKCGFQSTTTVRLLCPQSMLAEFLNEPDNFCCQVRDGEIDTASDEFPSFLYDQALYNPDELDAGLLRGPLLLSCFKSLFTGPGSVLLNHGDREGRSSRPGHPPLAKKYDMTQVSPRSIAYVAVLVRFLLNSQQSWSNIDLNFDLEQFFFEILRLFQDEEWGQATLEWWNKAVFGTTAKTAKKKTRPQSAITKLKAQCAARAAVQSGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVH3</accession>
    <name>A0A401GVH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617128.1">
        <property type="nucleotide sequence ID" value="XM_027761327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVH3"/>
    <dbReference type="GeneID" id="38783132"/>
    <dbReference type="InParanoid" id="A0A401GVH3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="9058" checksum="042501697F2A978C" modified="2019-05-08" version="1">MADDDNRKKQELDRGYKVRPEVRIDEALSPVGPGAGLFVALGISTRRRSWRARRGNQRALNLSLHCLLFVTLFVILGLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVI3</accession>
    <name>A0A401GVI3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0900950</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617129.1">
        <property type="nucleotide sequence ID" value="XM_027761328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVI3"/>
    <dbReference type="STRING" id="139825.A0A401GVI3"/>
    <dbReference type="GeneID" id="38783133"/>
    <dbReference type="InParanoid" id="A0A401GVI3"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="278"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="444"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="735"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="739"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE86216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="957" mass="103906" checksum="78537F6FD2BF3C28" modified="2019-05-08" version="1">MDSRSPICSFYLRNGCARGQQCRFYHPPNTIAHAPLTLAPSTFSTNANRLCVHFVRGDCRFGDRCRDRHVVPDSPAAELKSPILISPVSSKVTPTDKYIDDAAICLYFRQGSCRFGDQCRLLHTPEALKTASLLSISSTGLQPSNEQSWSASKAGKVSVFGPCKFFVQGRCTQGAACLFPHVAPVQPAPVEIKTNSTSGAARYAPSATAITEDAADENHSQDDLPSNSQIALTFSDPRNVHSTGSGEDSIISRQFLGCSVQFSSGASIDSVITAFESPRIIISNLPLTMTQAELIELTERHGDLKTANLTERVSAATATALVEYTSPDHASMAVKKLDGKKLGALKLSVRLDLRRGASGAAVLQSNKVKLTWFAPSRVAWAHFDSISAAKAVAQRINGQEYDGRKVSATFQTPSPFQRTSFAVELKGLPVHVTQTRLSRWCLTGSLKIGQLSYDEQASLEEIQSLLRRHGALDAFDVLPNLTASRTKITAFAQFGTAEAAADAVNALHRKSQAFLRYSTIYLDVVHAVKGVLPKAQYVVIKEDLERLCATLEGCKMRFYDRGDAGELLDSVGYRIYGANAKAIGRAKLQLDRLLDGEILISDVTTGGALWDEYFQSSDGRTFLDTCDEVGIFVKTDPRTRVVRLFGPSNARSQARARILVRLAIIKGQRHSIPLERGILPEVMNRMHALQEAAGSAELSLNVVARTLVVRGDDVHVERVRRAVASLSSSSGVLSDDACCPVCFCDVSDPSVLPCGHSYCRSCLQLLLLSSAGPDFSLSSLVCIQSVDRDSQQVACGNAIPTSVLRDLLSPPEETRLLTAAFLAHIHARPDEFHYCPTPDCEVVYRTGRAGAVLQCPVCVARICPACHCEFHEGMSCAEYHDNVSGGHEAYNKWRLENGIKPCPKCKADLQKNGGCNHIKCVRCGTHMCWVCMETFSDSGTGGGVYEHMRRAHGGIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVS9</accession>
    <name>A0A401GVS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0901720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617206.1">
        <property type="nucleotide sequence ID" value="XM_027761405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVS9"/>
    <dbReference type="STRING" id="139825.A0A401GVS9"/>
    <dbReference type="GeneID" id="38783210"/>
    <dbReference type="InParanoid" id="A0A401GVS9"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="86"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="418" mass="45707" checksum="1A7968346D98DC80" modified="2019-05-08" version="1">MSDPPTENTSPSESERVNGDLRASETGKPSTADSGTTSPFLNPTAATSHPAADTHASDITLPEDHTPDLPPRVPDMPTPVEAVQEEEPPQIAALRSMFPDFDSLVFQSVLESVNYDQDRAIDVLLGMSDPEYVSTSQATAPTQPDLTLDEQLARQLALEDQQQPRRPASGHSWPRRNQVPYQPRQQHPRSPPQQQQQQQEGYVTGNERGDFQEFQDTFSRIAESGKRTFSSIVSKAKAKINEYQQGRPSQTSPPLTQPQWGSAPPNQPDRHTAQQAYTQEYYGYDHSAYPVSPQEQPHVQGYDAGPVPYSNIPPRSAPIAAPTPVVPPPNVNPNITSPSNQPSSSVSPRPSGDTPRPPPTMSGSPINAAKLGLLPKRTVNLLNSQPSTTQAPQVQPAAARRPSEDLEYMENPFEEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVW5</accession>
    <name>A0A401GVW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein STE50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0902460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617280.1">
        <property type="nucleotide sequence ID" value="XM_027761479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVW5"/>
    <dbReference type="STRING" id="139825.A0A401GVW5"/>
    <dbReference type="GeneID" id="38783284"/>
    <dbReference type="InParanoid" id="A0A401GVW5"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="13"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="6">
        <location>
            <begin position="241"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="456"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="561"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="327"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="74196" checksum="E49FDD966F98BA42" modified="2019-05-08" version="1">MDVLEPRTSIIDWDESDVNAFFTKLGYPQYEIQIREHNISGDVLCLLDAEGLKEIGVATIGQRLAILKGVYNIKLAQNIPIESDHYVPPSEVDERQEYMNVDRLYDLLRDQSERLHMVEEDNRRLTESLHSCLEDIHSLRSATHSAIETDSPVQRSHSFKWASLGKAIRSPTKPAPEVESPQSSPQRLEHDFSSRNPPPERSRPPQPSTMHDTPYSQAPTGNSGNPPQPKPVRQESSDNLKSFKVSLDDPAWKVLPAALKKYKINNDDWQNYAMFICYGSAGNRIERCLSYDEKPLLLFQKLKDAKKNPVFMLKHIKDIRSPIAVAQQKQAARKASSETSSAKSPPLSSASLQMQAQGQGQTQEQGQGQTQDSASRPPKLQVISHLGHTAPPLMTGVPNAQSGWPELMSPAVESKERTEELGPDSGKMQSANPGNGAGDGVDMVGPSIVREIPPSTGVSYAVAIYPYMAEQEDEFDVVVGDTFIILSRARGWWVVQQDPAGSGLVEPDTSKQGWVPAGCLLETSVPVAIAIAEATARSSSAGSPPPSPAGKTPILPLSILSTSFPGIALMDYKKKGEEELDLAKDDSLRVFKRYNHWSYAVKEESGDRGWVPSWFIGKVPTPPGAPQTPSTSGAPNALSASLMEGDSRYANDSQQAQVSPMSSAFPPMQTQTRTTAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXB0</accession>
    <name>A0A401GXB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1000640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617735.1">
        <property type="nucleotide sequence ID" value="XM_027761934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXB0"/>
    <dbReference type="STRING" id="139825.A0A401GXB0"/>
    <dbReference type="GeneID" id="38783739"/>
    <dbReference type="InParanoid" id="A0A401GXB0"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019043010" description="ER membrane protein complex subunit 1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="14">
        <location>
            <begin position="18"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="13">
        <location>
            <begin position="796"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE86822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111026" checksum="D3783141909B95A6" modified="2019-05-08" version="1">MRFLSLWLAASCISSVWALHASEVGVVDWYKSFAGVPRIGAISTAPVFHRIGGSNGSTQSLVLTATEKNVLAAISPVDGSLAWRYLFDQDEHVIGLKAHQDVVAAVSGSGGATLRLFDALTGDLRVEKRLHRPDAGRLFEPETLGTAIAFEKDDVFVLSNGHILRRVDSKTGELKWCWASPDEASLVVYSKIIATPSVTYVVGLAKSFASYTLHVTTLSSSTGELLESMSIPSSIKDGLVDFLVLSTAGQSELTPHAIWFEDGSIRVLKLTPEIKETSSTSKGAVYKRVVDVGLSEHGQFVALKDDGTAHIFKLTEDGLKAVWEFRDSASSNQYAESHYVGGLDKDGWPFIARVYWSHVFKKATAHVFAAHLADGKGFSTSFTFPFETSVHGVMTHVALDAANPEEFKVISRLVLTTSTGAVQLWQQDQLHWTREEALSDIRVAEFVELPERKIIAALGREEEETFMARLVRQTSEAQDFPQYAINFVKRFVTGSYASVSSSVASPTNASEPLSRDTFGLRKIIVVATPYGKVYGIDSANGEIVWSRVFGLGWAAEVGGHILPVKLFVTRTVSDGDSPQVVLITQRRASNTLVDTVLFHIDALTGADVRGVSPAGALLQGLDVIAGPLVEAYLLRSGNSKIVVLLDEFVQVHLYPDTSESTAVYKKALPSLYFVLRTGPRGSQRLTGHQISSVEELMGRDVAYPTWTVSLPPSEVIYSIIPKPHEPVASLGKVLGNRTTLYKYLNPNLVAVVTGSSSPPSASTCSVYLVDGAKGTIIYHATLPSMVDSCDIHVALTENWLVYDYYDGELGVDQAKSHRIVSVELYEGSGVDDKRRSSDASSFSDESADVTIFEQSYVLPRGITTISATSTSYGISMKDIIVANENHQIQSFPRRFLDPRRPKQKPTNQEMEEWLTQYEPLIPDDPKRVLSHNYEVAQTKRIITSPALLESTSLVFAYGLDLFFTRVAPSSTFDVLSENFNKAQLVFTVGGLALAIIVAKPMVSRKRLRERWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXV2</accession>
    <name>A0A401GXV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1002840</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617950.1">
        <property type="nucleotide sequence ID" value="XM_027762149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXV2"/>
    <dbReference type="FunCoup" id="A0A401GXV2">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXV2"/>
    <dbReference type="GeneID" id="38783954"/>
    <dbReference type="InParanoid" id="A0A401GXV2"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="552"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="365"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE87037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="825" mass="89003" checksum="A715D6FCE01139AA" modified="2019-05-08" version="1">MAFNQVTATSLTPSRPAPAAPIRRGTDIQNVLAASGYTSSFSVGTSSPSGSSYASSYSGIGGSPNRNSDMSSHSNTVRVGYVSIKEDGVISWLWRPKWLILKEQTLTIHKNETTVQYQSLINLGDIANIERTDLKPYCLLLETKDKRIFFSLKNDEELYGWQDDIYSRSPLMGVSNPTNFVHKVHVGFDPVSGAFTGLPDAWSKLLTKSAITREDYAKDPQAVLEVLEFYTDHKKREIEEMGDFGGTLSPRSTSGTSASTLVGSTYSSTSTLTPYSDTTSAPRFNAGTGLGGAGMNKMSPLTDTRPQAKRQDSAPATMNGTDTVTGINGVQMSSSAALARAAELVNGSHAQHANTISAAQANPALRPTIPPMSAGSLQASRPAPARPLLTANRPAPPAPHGGLPKPPLPDHTPSSADLRARARALGPPTDTQTAKPPSLQKDLSGESSDKTRPNIAQTKTAPATTLPISQSTSGSGATAAIKPLQPMKKPSAPKEPAVTVTPPEERGGGVAAAAAALEKPKEKEKRISTMNEVQIMEKLRSVVSEDDPKTMYSKIRKVGQGASGHVYVAKTLATGKKVAIKEMDLSNQPRKELIVNEILVMKESQHPNIVNFLEAYLVKSNELWVVMEYMEGGALTDIIENNTLEEDQISSISFETCKGLGHLHSQHIIHRDIKSDNVLLDAQGHVKITDFGFCAKLTDQKSKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPTLKKPEALSRELKGFLSVCLCVDVKSRATADELLEHEFLKKACALSGLAPLLRFRTKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYA2</accession>
    <name>A0A401GYA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1004300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618096.1">
        <property type="nucleotide sequence ID" value="XM_027762295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYA2"/>
    <dbReference type="GeneID" id="38784100"/>
    <dbReference type="InParanoid" id="A0A401GYA2"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="849"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1247" mass="133866" checksum="1FA038B270617BE1" modified="2019-05-08" version="1">MSVGQKPATGISLVYGQPEHASPLRSAMDHLPLLAHSDTASIMTQDKTTFQTNGFESPTSAVRPRVEEAEDEDRTRKRSRVDSLASGSDEHDVNVPREADVPVTEGTGKAQAPSPPPHDSQPVSSPEISIQTPAQPVTQTQTVELADAGVKRATISYKPSCLSWFGSRPRTNATEVLMKATDDIVPAASDTPLVVQRSNTSPLQNIVETQSPLPTVDTTTPHNTVTAGSQFQASPTSIQTESAVYPESVRQLYIQTTQKPQARPMEPMLSTRTVTSVDDEVPGPKPSSLSSTPSEALPVLVQSEDEGERGRKLAIASLNPSSSRFTLRLPLLGRPKVPLEQIAVVAQAGESAGPRESEPVPDASGRDTDAQPSVTSLALVDGSLSVEPSTSATQELSSVVSASNSPVEAVASQEPSSSADVNINEVSANPTPASSWWDYVGWGHSQPVQADQPDPKPEQTTTGGDINIIATDTSTHVFPKVPFSPSTSQTPMTPTPLGSLSATTQSAEITKASSLREAVQRREEALPGKPTPSEQEPASAFPEPVKSERSTWYSPWAWYATSPVSPPYDSALSGATATGATANSESGETAKMESEVVKTQALARDHPAPTVVAESSRAPPQVDPPPVEPKNPIESSVSTHRSGWATFFMSRALVTKSVSDEQKDRDENGMEIMNLDEDGDAPKAPSDPIIIAPAKPVQQLTSLSPKASSSAFVKDKVRKSETSPLSDKNTREALKPKTPRSISPTPSKAPSVSSTAPRPPNLVLPGFEEIFHLPPRSTFIPISKAGKSKLSQTLSFVSGALFSKEESAQGKGKGKDKGNPFLHFGKELPKALDVVGEQLNSYIMSGGCRVVVIGVAGWMPGAVTRTIAGGLPSSSTKFVNMTCQALERFEQQHGFKFKKITKMPLEGDGTIERKVSKVHQHLLSNDEWMEDLHAADVIFVATHSQGSIVSTHLIDMLIQDGHILTTRSVDILTETAATIAPGGAASLSATQAQRVCFLALSGIHLGPLRYLKMSSLLQPYIQYFENSSASELFEFQNTESPLSKAYTKALSNILDHGTKVVFIASLNDQVVPIYSGLFSAASHPRILRALYIDGDAYHTTDFLTNLLILLVRIMNAGLSDGGLLAHLSEATAGSLSGIGHSTVYEEPETFSLAVNYFFLANDGDSPASLSVQPFDAVVEQNDYEIPWSLRDMIADERVAYFFAHEFAQLRDTFDDWQPKTTILRDVKRKLQPIQRLSAIVSHTTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYD5</accession>
    <name>A0A401GYD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1004640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618130.1">
        <property type="nucleotide sequence ID" value="XM_027762329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYD5"/>
    <dbReference type="FunCoup" id="A0A401GYD5">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYD5"/>
    <dbReference type="GeneID" id="38784134"/>
    <dbReference type="InParanoid" id="A0A401GYD5"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="150" mass="17088" checksum="3B774D7A068713D3" modified="2019-05-08" version="1">MARHRIFYDSLPFSQLDRLIEEALTSEQRSNDNFQLMNGSQIWRPRMDVHEDLKHNRAIATFELPGLQHQDVGLEFLNGNLTVSGELKPPAGINIRAGVRERRYGKFARVLFLPSDVKPEDIKAAMENGILTVKYPLTSARHEPPKIADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYQ1</accession>
    <name>A0A401GYQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_1005280</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618194.1">
        <property type="nucleotide sequence ID" value="XM_027762393.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GYQ1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYQ1"/>
    <dbReference type="GeneID" id="38784198"/>
    <dbReference type="InParanoid" id="A0A401GYQ1"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="1109"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="1659"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="906"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="912"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE87281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2407" mass="273539" checksum="F9F7A267AB1F482F" modified="2019-05-08" version="1">MRASTAIPTIWDTLHIATTSFELPVSSDVLYLVSHGSLSFASGSVQITDEGSAGSDVADVEITAFFDHEHEFALTRVCALTACGGGERRRYIRKHPLLLAGGTIKFDSRSRLSCPPHPSPLFINKFETHLPWFAHHVGDLKDSVYFGRVSLRSAFIGYDVSSLFGEHIDVTTTLSAIKGSFNPSSYLTLHTSNAPISVQVGMLNDPEGNHTVVEIHTSNGPIKANMDLLSAASSGTGGNFSVDARTPQSTQCCACRAHVELARTRSPAPNVRGRIRACVVVPVHACRRPQHGRGGPRGVRTRAPAHIVILQSLGIATQGNLSTLDLNFINPTALPKQYIDLLPSQAEWDAQRNVHVLNGRPLLIRPDQHIDHPSGDYEAGLPHNVGGLVLSHIADSGIPISYPGERPDAPWNPPVQDPVPQPILAPIISDYIPPMATVTMDEGRHHVSQKELGFRKPEIFNGSDHSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYTSRFDNQWRSAQIFKRGTTTTTRGKGRSVHRPYYSASAKDPNAMDVDRVSISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLEKEDVTTEALIDSGAAETFMNIHFAEENDFIRWELPKPITVMNADGTPNQMGTITHCTWKMMKIGGRKTLTRFLLTGIGKENILLGMPWLKRLNPMINWETGDFWFGKDAKWPPKPTVEDAPDEEVSIFKEDGLPELITTETSPTSFRHSESIREITADNTERGELPAVRNDTEPDDPPSETPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETTVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPHDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVRTRHVLQRLKDSDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPTTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTVAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGDLHPCAYISQTLNPAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSRRNGLDDSESDNEDRILLPNALFVRSISPTLFDEIRNHAAKDLIVHEALEAIAHKGPFPMKSSLSDWEVRDGVILYKGKIYVPPSETLRRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPTDPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLRLYCGNNPETWADRLPDLEFCHNTREHSARKMSPFRIMMGYEPRGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIAEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYMNPPPDVVDNEEEYEVEAILNHKTYRGHLRQLWNGSLPLIKYVALEHSAFMNMINIAARALDGVTIPNCKCTREEIMDMFKCRLMELQQKLNSDAVQGLVNLMCNTWQASNTDDYFAITDLWVEETGPGLWSVQTALLSFMQLSNAHNKKCLSQALFKIVAQLQITHKMKFVKHIRHEMGKIYDAKRCRIRCLAHIINLAMQAVISTYSKSKHFDPEKLNEDLTAPQVTQHDEIGLIRLICVKKHSLAKCKRLFKDIQVKEDTKNPLQLLLDMLVRWSSILLQCINTFIFKLGCKEKDQSKRKKLDELELSDQEWGHVKSFLDLLAHADNAQQAFSTDQGLTLHLALPTLKALHKAWSSRAECTKYVDFMEALEADIAKIVEYYERFADSETYTIAMRASPYHHHSILILTLRHARSTVLDPSEKINYIRKYWNEDLLKEALEHAEVMVHVHFTSLHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ40</accession>
    <name>A0A401GZ40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1101070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618344.1">
        <property type="nucleotide sequence ID" value="XM_027762543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ40"/>
    <dbReference type="GeneID" id="38784348"/>
    <dbReference type="InParanoid" id="A0A401GZ40"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="129" mass="14033" checksum="3578634B7CC0A879" modified="2019-05-08" version="1">MPPPQPPHLIIVDPITVPTPQLFNLLGGASTSSISTTTHDGISIAHSLHANPPPDYVPSWNFDKSPNHHAEGLTPEMAEEAMQTEMIEHSDQSIQTLVNPGEIKTPFSLTFSTALIGPQRTILLYVAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ74</accession>
    <name>A0A401GZ74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipase C/P1 nuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1101410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618378.1">
        <property type="nucleotide sequence ID" value="XM_027762577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ74"/>
    <dbReference type="STRING" id="139825.A0A401GZ74"/>
    <dbReference type="GeneID" id="38784382"/>
    <dbReference type="InParanoid" id="A0A401GZ74"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF29">
        <property type="entry name" value="S1_P1 NUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="54126" checksum="2305D01BC21E6016" modified="2019-05-08" version="1">MPVRTRSGIGPFPKAIAENSSVPSLAAPRATEAVGCVAIGICAATTSQLEAAVGIATFVFVVNVQHTSNSISAVRTEAASMRILAFSVGVGLTSLPAVHAWGAAGHEIVATIAQIYLHPSVLPVVCDILYPPEPDAVPATSAPSCNLASTASWADRVRRTPEYSRTGTLHYIGAHDDAPGATCAFPGPKGWIGRQDHNVLGAMRNASTILQQFVGDGSYGRADGEEALKFLVHWVGDMHMPLHLTGKERGGNGAKVLFDGRLTNLHSVWDTLLIASALRTIPQNYTRPLRGYGASTVERNLRGAIYDPYVRRIMHEGFGVGAPTLHDGRFGAYTEWLTCPAVQDPSPESFLEKAQAFFGLGGRRPKRPDEERWDDGVLCPYAWAVPIHQLNCEIPIWPKELETVAQRVSPKGAVTGAVGRRDDGYDHIDLSTHPDFDSIAWGGKPRPHPGMIELDTPEYAGQVRERWVIERLLAMAGIRLAAILNGLFAGEANATPLMELYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZA7</accession>
    <name>A0A401GZA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1101710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618407.1">
        <property type="nucleotide sequence ID" value="XM_027762606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZA7"/>
    <dbReference type="GeneID" id="38784411"/>
    <dbReference type="InParanoid" id="A0A401GZA7"/>
    <dbReference type="OrthoDB" id="3358294at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="67" mass="8040" checksum="A0AB64F6EB5EC893" modified="2019-05-08" version="1">MYGFVFRIFWLAGGLRLNSRLRVPDHWESWKTEAERQELIQVMRQTEVNRPETPSYVLQAFLKAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H081</accession>
    <name>A0A401H081_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1200130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618702.1">
        <property type="nucleotide sequence ID" value="XM_027762901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H081"/>
    <dbReference type="STRING" id="139825.A0A401H081"/>
    <dbReference type="GeneID" id="38784706"/>
    <dbReference type="InParanoid" id="A0A401H081"/>
    <dbReference type="OrthoDB" id="2685034at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="495" mass="53069" checksum="57FDAC92D3C0FF9D" modified="2019-05-08" version="1">MALNTSGTSGVAGSSSHTANTQQGPEIEGIGTHAYYPTNVAPYSSSLSGATSLPSAGPSHSHTIPSTPGPSSGKRRQPDDPSTTPSSSASKRRRAPVASPGVAEERADYEKEDPDVGPNGGPKHWTDQEKTNLFTWILCNDAHWDAFNTKMNTVFRDTATAIFGSRKTFTALKSCFHRNLEVFKQIYALEAFLARPAPPIDGAPDAVHHVAGVPAHFNSATERQSFLESRLEAARAAGAPVGNLNVKVIDHWYTMGWYGLFKNRYQEDQKTGLPVPLFGLGKTTLFADAQHNIDPQLVDDNPEQDLNAGHAQERENTVQPSNSSSTRGPAPQPQPPTASLIPPPVNLRSISQGQQYIVSAAQPPPMPYPGAPFMPMHVHPSGPTYWDSRQAPAEYPPQPPPGPPQPQSQQEGAIVQALDRLTAVSQSLVEACTDLSGLLRTQAAAGAGVGVGKEAERFNKKEKAALATEVLANSEVSDEVRKAAAEYLKRLFVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0F3</accession>
    <name>A0A401H0F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate-dependent sulfonate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1201300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618818.1">
        <property type="nucleotide sequence ID" value="XM_027763017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0F3"/>
    <dbReference type="FunCoup" id="A0A401H0F3">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0F3"/>
    <dbReference type="GeneID" id="38784822"/>
    <dbReference type="InParanoid" id="A0A401H0F3"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="143"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="456" mass="50758" checksum="35A369526F82F366" modified="2019-05-08" version="1">MHLSCGNAPTTPVVLLPADHRAPSAILATCPYLLTPWSPCVIRYSRPEQHSPCTGTTRLSATYENSKLDGSARVSALKDAVKVVNPFYSPSVGDDGDDKYEFAQYKPRFPEIKWAPLGEIAVTERGLLADKSKKNLFSAATKVQNLTPAIGTEIEGIDLRQLTSTQKDELALLVAERGVVFLRDQEFSIHEQLELARHFGPLHKHATTPIPREPGLEEVHVVYNDATRRPDSSTFSKLELWHSDVSYEAQPPSTTSLKVISGPEYGGDTLWSSGYALYSYFSPAFQKYLESLSAVHSGVAQAEGNRAAGLPVRREPVESIHPVVRVHPTTGWKSIYVNPGFTRRIVGLPKAESDAILNLLFHQISENPDFQVRFHWRPNSIAIWDNRVVTHSATFDFWPQRRHALRATPHGEHPISVDAYEGDGKVAKDRQVEIWAEQGISRVENANPTKPRGYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1E0</accession>
    <name>A0A401H1E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1300270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619126.1">
        <property type="nucleotide sequence ID" value="XM_027763325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1E0"/>
    <dbReference type="GeneID" id="38785130"/>
    <dbReference type="InParanoid" id="A0A401H1E0"/>
    <dbReference type="OrthoDB" id="2757435at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="493" mass="55186" checksum="A5F638AF043A301B" modified="2019-05-08" version="1">MDVIKTETSDIGQHHGPACTGASTEFIKVYPPISRDSVPFIPAEAEDIGEWQNIVRANLPINIDESTEVFIQASTTSLAARALQFLLLWHFASPPAPYHQFEAALERALPGVVCSFVPLAALLSSKRVFEVNVGVGAAPEKAVLRDAIAQMTSEVRFWVEKGVYKSLVFHSSTDHFRTRDCILKAYGFLCLMHLVNLGQGPEPVSPFLLQAVIDGHSNILIDREFILSLDPGQFAVLQPWYDWNGTSPLTTDPKTDLGALLIEADIVIEALSLEGMDEAERNGVERTLVSRVLLGHIDPTHHPDLLAFREGLNFQLRPGQDIRKTMEGRTKALLGALNDKEDQQTEVERQHELRFAELLIRYLHGKGHPDHEWIRREIVPEDMYMKEHENVVHRVRLLLQVMTGSDLLPLGEHWKLKFSFTHASSYQDGGAHLNNAEEITPILYSACFMQGKVTMDVGLQNLLLQEVDGPDHALYFDAWMHGPLMAGDGFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H214</accession>
    <name>A0A401H214_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1302480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619346.1">
        <property type="nucleotide sequence ID" value="XM_027763545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H214"/>
    <dbReference type="GeneID" id="38785350"/>
    <dbReference type="InParanoid" id="A0A401H214"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="8126" checksum="24E17FD8BECFA417" modified="2019-05-08" version="1">MQAVLYLSDLRYSYSQPSLLVLLSIRHIRPDDVYDEQNIVRFATDALPPWGRFRISAYLLRSRLLVRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H226</accession>
    <name>A0A401H226_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1302570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619355.1">
        <property type="nucleotide sequence ID" value="XM_027763554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H226"/>
    <dbReference type="STRING" id="139825.A0A401H226"/>
    <dbReference type="GeneID" id="38785359"/>
    <dbReference type="InParanoid" id="A0A401H226"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="21534" checksum="FC6CC09D7EB957FC" modified="2019-05-08" version="1">MPPRQHFNAVVLGAGGVGKSALTVRFGRNQFVEQYNPTIEEEYTCNMVIDGVPCVLDILDTPGMEQFTALNEGYIKGGRGFLLVFSLTQEASLKDVDDIRQLIYQIKGDKTVPIVVVGTKLDLTHEREVSRSTIQDLAMRWGLPFYETSAKRNWHVSIVFEDLVRQMRKRYPPGELSPRKRKREECVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2C4</accession>
    <name>A0A401H2C4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3'-5' exonuclease</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Werner Syndrome-like exonuclease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1303580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619455.1">
        <property type="nucleotide sequence ID" value="XM_027763654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2C4"/>
    <dbReference type="GeneID" id="38785459"/>
    <dbReference type="InParanoid" id="A0A401H2C4"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046616">
        <property type="entry name" value="DUF6729"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF109">
        <property type="entry name" value="3'-5' EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20499">
        <property type="entry name" value="DUF6729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6729" evidence="12">
        <location>
            <begin position="383"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="11">
        <location>
            <begin position="741"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="44"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1001"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1027"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE88542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1125" mass="125726" checksum="3B8FD217A09A9FB8" modified="2019-05-08" version="1">MENEERDEYDEYFWEFDYDSVEAVTPRLQLTSKNVQMELVPSKSANNFDAQKQNNAHQRSLSLPRNAAVIRPSAPPVSRSNSTRRSSDEPQNARLRSLSLPRSTAAVRPSAPISQSDGTRRSSDEPQNEKRAVRANTTSTAGSVVVTRKRGRPKGTGHKQLARKAAEEAGEVSEEPIRRGRGRPRKNLQLVASSVRVEVIQDKIHIRGTPGTTASTLQHKNAPTIVSVPPIIDNQDDLSLAPGHNTQSPTDVTQPVDISSNCEPLDPPPAIRYVLPEEDPTRPVDGVADEEAVDGDGYIGLVMDGLGQEDDVPVEDEEADPGEVNAGDSPTAPKSKRRALPSWLMREFNEKVTEARQRGDSDKLPALYRSGTFWFPQKSRYFTLRSNKVSPQDLYSPQFFLWDPLPLTPHGIPCPKCKTKLYRDGHVLYPRRVVDFDKAFWIIGYRYRCPSCIFPKSGKTGNITFRSWDSRILAQLPPDLCAEFPAYLSRRSGMSQQVFQFMRSCFQNGMGAKQFSDTLRVQHLRHYDLMQLQYLQFLQGHRALGEWLGDRTFAPFLPFDDTSLDGYHGFVPSSQWLRNMYDQFMEGHEHDINQHTSMLTAEICAIDHSHKITKHVLKMNGVEIYCGLLTVTNERGEIRVCNLVATKAHSQFELALVRMRESLELYGHRQPTLFYTDNMADKQFLETSFPSLRENVIPVEKYAHLDQLVIPSHVNVYVKETADAIQQAILTIIDQVDENNPITVGFDAEWNVDLAEAGQSHGRARTAIIQIAFGNQVYILKIGQILAAGAFPTSLQSFLSSHHIRKVGRLVDVDLCHLEMETHSSMPFTGGFDLAKMAKERHVVSSAQVSLSDLCAIVLQKCLDKSVPERVSMTWENVTLTQEQIKYAALDAYASLRIYEELQKVPAPGPLPLNPLPSLPVLLYHTDNTRLIAKGIISHYASKDKYDEINLTSKRTVIQVDEVLVPGAIIGTHHKRALTDFGSPPFDLVCLRSHLRTRQSDLITSEASPSGSPPSVISSAAENNSRHFDALSDGPVTGSHCSEDESVSQDNLEGIGPAVLDCEEAEPVPWDSDISGIDRDQDSEATGKAILDALPSQWDLPIRSRVLKDPFHVFNMLYIPKTHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2D1</accession>
    <name>A0A401H2D1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1303650</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619462.1">
        <property type="nucleotide sequence ID" value="XM_027763661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2D1"/>
    <dbReference type="STRING" id="139825.A0A401H2D1"/>
    <dbReference type="GeneID" id="38785466"/>
    <dbReference type="InParanoid" id="A0A401H2D1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019035724" evidence="13">
        <location>
            <begin position="20"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE88549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="636" mass="65381" checksum="691DB6E4E1165696" modified="2019-05-08" version="1">MLSVILLTAFSATVPLASGHASIWHSSMWGFNVTQQTFSYDNRPVTPLMNYNFEQWWFHGHLDYPPNPGDFFELPAGQPATAEIACDKGATTWFASAPGGNIQSGNDPCPGSPPSEYHTTGPDDLKGCSLAIAYKSNVSEVQPEDFVVFSVNQTCVWNRFTDFQVPAAMPPCPDGGCICSFFWVHSVDSGSEQNYMNGFRCNVTGSTSSVALANPQLPRRCGADPDNGKPNASLGNCTYGAKAPFYWFQAERNNMFEGQYAPPYYDDLYNFRDGAQDDIFQNSYPNGVPAPSPNSTIVPSPVPFVAGAAAAPIAASSLASPSASLSSAASASSSLPASASSSAAVSVSSSAFTFPSNSASFVSASGSSNSVAPASSGNSAVSGTLAASSSLSVSVSTATVISTLVVTVTAPASPSVSASSSNISNSEQASSSQAVSSFQSASSSRLPSSALSSVILLPPALSSAIPLSAAQSSAVPSASATSSSPILSSALSSTSAPSSVPPAVTTIFLTKPAFSASASASASASASSSAFAPVSAPASASASTPVSSSSVSAQNTTAATPTESGAAMFELDHDNALFAATSSSAPAISATANMCKQQFTRRSFRRRSLDNDAPRSRFLRSRHKRLHDRSSLWHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2K8</accession>
    <name>A0A401H2K8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1400660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619574.1">
        <property type="nucleotide sequence ID" value="XM_027763773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2K8"/>
    <dbReference type="STRING" id="139825.A0A401H2K8"/>
    <dbReference type="GeneID" id="38785578"/>
    <dbReference type="InParanoid" id="A0A401H2K8"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="30"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="257" mass="28227" checksum="28D6A2BF3418A804" modified="2019-05-08" version="1">MQNKVPTPTVPQNTAGMSSSLHQRSDQFVFFWKTGKELPNGYLSAWHLSPFMHEGYIYLTVHQWMAVQKARFFGDKSAEEKLHETIDPEDISTIAAGIKGDGAKKWGSMMGKAAVDGSYLKFTASLQAPDLKAKLLETGDRTLVKASPCDRFSGIGYGESIALSKQQFWGGNIMGKALMEVRRRLVEEAQPLPGATSRPATYDFDIEIMSTEDDWEDTPAPTADELDSSSMDKLTGLCAAVEQLSKCMDAMEVAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2N8</accession>
    <name>A0A401H2N8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619610.1">
        <property type="nucleotide sequence ID" value="XM_027763809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2N8"/>
    <dbReference type="GeneID" id="38785614"/>
    <dbReference type="InParanoid" id="A0A401H2N8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="109" mass="11831" checksum="5988DC24E32D74DE" modified="2019-05-08" version="1">MHPLSRRRLVYSLGPLFSTLSRLSLRISRPLAFSCHSNTGATRSPSLSSHLRITRPTRNEMEGDLAAITLDGMTIAHHLSPALRVQTTSGPPSPVLSCQRDLWSNGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Q4</accession>
    <name>A0A401H2Q4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619586.1">
        <property type="nucleotide sequence ID" value="XM_027763785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Q4"/>
    <dbReference type="GeneID" id="38785590"/>
    <dbReference type="InParanoid" id="A0A401H2Q4"/>
    <dbReference type="OrthoDB" id="10638854at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="164" mass="18768" checksum="F810E5D222732F26" modified="2019-05-08" version="1">MFPNSPQDIELDTFAYESSPNWQWYREVAATADVGSMLFAWASRDCHWGALTAAQHALDDTNCARMSRGDEQTLLEKKGKLQAAYDDCLDTWCLLEWRRAQQVTFFRRCHSRAPHPTHQASGRERRAVWSDNQAVGEVARLRIGAKIRLCTELTTPARNAYSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2W4</accession>
    <name>A0A401H2W4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1401900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619698.1">
        <property type="nucleotide sequence ID" value="XM_027763897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2W4"/>
    <dbReference type="GeneID" id="38785702"/>
    <dbReference type="InParanoid" id="A0A401H2W4"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="236" mass="25754" checksum="6F197C91C85ABDA7" modified="2019-05-08" version="1">MTPYAAQHNVRLVLLNLHDYPGSSPYTPAELDALRGPEPAAQAKVLLACGLELVSFVHWFIIQENTPSISETPERFGALIGGIVLVPWSAGNSHVLSMLAHADKVPEETKVLLDSHLRSIVLYDPSLTTVGTLPPNGLYSPLRERNLTTDKMVAIFPTWVSSYFPQVDDLASDEATMLTLVLSRVPLELRGDAAAARDPHRTSTVERMGAEMLASVWREPSPCPVSPLLPSGERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H372</accession>
    <name>A0A401H372_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1402470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619752.1">
        <property type="nucleotide sequence ID" value="XM_027763951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H372"/>
    <dbReference type="GeneID" id="38785756"/>
    <dbReference type="InParanoid" id="A0A401H372"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="100"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="328"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="9">
        <location>
            <begin position="545"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE88839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="68215" checksum="EC2EF610C64585A9" modified="2019-05-08" version="1">MLWAENAAMKSEFASLFPDDIPHLDDLPTNIYHHFTLKDPEIVIQWRQYNCPKKYHEAWKVLLQQHLDAGHMRASDSPYTSPAFLIPKADPDALPQWVNDYCVLNSNTVPDMHPLPRVADILADCSQGKIWGKIDMMNSFFQTCVHPDDVKYTAITMPFRLYEWLVMPQGCRNAPLTHQRWMFTALRPLIGKICHIYLDDIIIWSQTLDEHRCNMSLFLTELDFLGHYISTNGIEADPKKVEKIVNWPIPHNTGHIRAFLGLVCYIAPFLPKLANFTNVLNPLTTKDAKLHFPQWTTEHQRAFDSIKELICSREVLAVINHDDLGCNKIFVSCDASDFRTGAMLSFGESLETACPVAFESCTLKGAELNYPVHEKELFAIVRALKKWRVDLLGVPFTVYTDHRMLKNFFHQKELSRCQARWQEFLAQYDFKIKYIKGEKNIAADVLSCLPADLDIIDPLCHAATAILQTATHALCHIHEPPTPLVIAASSHLSISSNLEWLHLIKDGYQEDKWCICLHSNLGVVGTREQNGLLFIGDRLVIPHVPKLREAIFRLVHNSLGHFRFDKSYAAICNGYYWPNMCKELEELYVLACEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3A6</accession>
    <name>A0A401H3A6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619807.1">
        <property type="nucleotide sequence ID" value="XM_027764006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3A6"/>
    <dbReference type="GeneID" id="38785811"/>
    <dbReference type="InParanoid" id="A0A401H3A6"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="858" mass="97522" checksum="A047C7323A53760C" modified="2019-05-08" version="1">MAAKERSNILDRMVAFLQKEFGTLEDASRMPADYVIMMLVKGDPQLPQEYLNVSNAEELCQNQPQLVEMLKEACLSGDFNRFASAFLRIVQPKPPTPAALDYLINPFKTPYVGAAVDGLYEYLRENNRKFHREGGHYGKFCSIVQSSGSGKSRTMIELGSKGVMVLYMNIRDKADKHNWPPRDDIPARILAEDLGRLTEESYTQRCCIFFTAIFLHLGTRLRELFDLTGCRISRAIELWRNEMDGTLVGNRRVQFFQDVQETYWKITNPKSARACIEELLQKMDPVFFSEMSPKPLTAENYEEEFLDYEQNMRNSYSNLIYTLDDLMGTTDDPKLVIAIDEAHRLSTMVNDRFRPSHLLCRVISAYSCIRGYLGSVWVVFASTSSRIADFSVRSQIHNSQRAVTAGSRLFPPYTLTGWDQHAIPLADITYADDVSKAEHLIRYGRPLWHSNRLRDTVMLAKEKLCNGRTFNVHDSNQVLAVLGQRFSLDICFGHPEAAEFLETGVASHLRVCDAITEDRMWRFTSYPSEPILSHVAGWLLHNEPDYIVDALKCMERKIQDGLIELGKSGQLVSRIVWILGKDSLVRQLYTPTVPDRTQSPYLLYCQKVPLTKYLEKCFGNTVWPDNKQQAEAAKNAFQNAYVNFSHWISMEENICDEYRSDWCAKQWLLRHWARTAAIQCCHGQPLIDKVIPIYFHNAGRSLQDSMSLMMISDKAGATASPTDVNAIQAKHVSINCVTGLPCIAVTLDMGVVKTEVRSTFSAKQSPRLNSLGYADPDEEDSCLRIYASGMNAKTFPFLEEQVSLETLLQSIVQHATEPAYPHPVGERLQDEMIYGSTSRPRHMEWENGAKGPAELLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3D7</accession>
    <name>A0A401H3D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1403630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619868.1">
        <property type="nucleotide sequence ID" value="XM_027764067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3D7"/>
    <dbReference type="FunCoup" id="A0A401H3D7">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3D7"/>
    <dbReference type="GeneID" id="38785872"/>
    <dbReference type="InParanoid" id="A0A401H3D7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="342" mass="36730" checksum="531B0C5A215D41B9" modified="2019-05-08" version="1">MGGNMSVFLASCYPPNAAHYIAEVYPSSPKWSADQIGDLTGKVVLVTGANSGIGYASAFQLAKHGAKVYAAARSKEKGSTAVDKMNADLAQAAGPLKPGQVVFLQLDLVDLHNVKRAADEFLSKEDSLHVLLNSAGIMTPPKGSQTESGIELQFATNVLGHYALTRYLLPVLLRTAAAAPDGTVRVVNVASLATAMAPAGGIHFDNLAGAMNWGFGVYGQSKMGNVVFANELARRYTDAGIISVSLNPGNLQTDLWRHQRSFFDLKTVIHKYPIEYGMLTQLYAATAPEVTRADSGAYFVPWARRGPVLRKEAHDPVLGARLWEWCEGEMRRAGVEVPDVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3H4</accession>
    <name>A0A401H3H4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tf2-1-like SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619874.1">
        <property type="nucleotide sequence ID" value="XM_027764073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3H4"/>
    <dbReference type="GeneID" id="38785878"/>
    <dbReference type="InParanoid" id="A0A401H3H4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="8049" checksum="D184D4DEC95D2C8F" modified="2019-05-08" version="1">MHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4F8</accession>
    <name>A0A401H4F8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620238.1">
        <property type="nucleotide sequence ID" value="XM_027764437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4F8"/>
    <dbReference type="STRING" id="139825.A0A401H4F8"/>
    <dbReference type="GeneID" id="38786242"/>
    <dbReference type="InParanoid" id="A0A401H4F8"/>
    <dbReference type="OrthoDB" id="2797394at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="237" mass="26615" checksum="69262E79E5BA6A99" modified="2019-05-08" version="1">MKSEHQLDFAEVGALVRLAHKYQIADLRENGLAKLKMIFTDDLAVWEEYSDSRDTKFTGIRWIESDAISVVNLVRLTNAMTLLPVAFYLCCQLQPHELTRGVTRPDGTVERLSTEDLEVCIRARAMLMLAYGAGWMDLFSGVSNDCTQGARCMDGLSRIGQAVLLSSTRAQISYHSCLSNPRNVIAARCTDHRLCAACVRFITKKSLDWRRTVWNSLPAYFGLGKWEKLKTAESAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4H7</accession>
    <name>A0A401H4H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620251.1">
        <property type="nucleotide sequence ID" value="XM_027764450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4H7"/>
    <dbReference type="GeneID" id="38786255"/>
    <dbReference type="InParanoid" id="A0A401H4H7"/>
    <dbReference type="OrthoDB" id="3261690at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="273" mass="31500" checksum="28FD2CC4A524D0A0" modified="2019-05-08" version="1">MLAGREHVNHSEWRVFVNARQGFAAPPSDEYTIRRDYDSLLGISRSLPYISQLAVFPIPSFRETLTTSVHMAVKIQTTEGQRSVQLHKIPNILFGKLANRSQTRLFFPRLYVSGGLGRVPQPALKNLYNKVIRPTINEILPANVSHWPVSYEQAFSQAQDRQGQLHHHSVDVPGHYIQEFGREVIRRCDQDRDLKGAFFVHECRGTKDATVHNGTFEFDREESLNDLLRDYDTENMELGEWYVDVALEVHCPGHVLQWLEDGHWNVLEELFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5F5</accession>
    <name>A0A401H5F5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1602860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620536.1">
        <property type="nucleotide sequence ID" value="XM_027764735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5F5"/>
    <dbReference type="STRING" id="139825.A0A401H5F5"/>
    <dbReference type="GeneID" id="38786540"/>
    <dbReference type="InParanoid" id="A0A401H5F5"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="659"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="734"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="862"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1036" mass="112798" checksum="EA1183FB588BAFC4" modified="2019-05-08" version="1">MSSEYGSSDIDWTETRPDKALVVKCSYEGLNKRITFNSARTCSYDFLRQRVEECFSLSATSYAITYTDDDGEVTDISTESDLTEAIRYFHPANEEPISSAASILSGRSFNKGKITVRVRITVEYDGPSLSDTSSLVSLDEYRNRNGSDFSLSFTSPPPAEIDDDSVTISSKDLGSKYELYRARGAKTIVSAPSQEPLIARPARPPDDWEASSVPSIAPTLDLGDVQSARSSLANPFLDDDSPPEDSGHRDDPSSVFQRLKLEDTRQASSSHSSSTLHSERGAAWLRDQNARAVKAMLGDVPSRPLSYSGADSADMLDDASSAMGGELALQQDSSGKYYFAYTAGSSAGSQSAHDSGYDDRSSVYDDLGTSVAGSDEVVQSRPVSMEVNVFDLQGAASGETSDLHRCASSASTSSSSSSSSVSNPFTRRSNSEPTFTQDFVHPDVPHDVLPYITTVPPVPPQDPPSCSECGVILDAIRYVCSKCGEKKPPGAQENGGKGKDREVYVERSHNHSSHAHSPSLSPLQRATSPSLSSWSVVTGSDIPLRPLGDNAPWKPLPAIPSPKYLAVTPESMPSTPKETGYELCWGCIESAGVTHALEMSVAPGSSPGSGDWPSSPEDAQRALSQWRRSAPSQKGQLRHAFIEKSWGHKGWQDVEQDEHRSCTCSGCSTVIVNHRFKCASCKNFNLCRACYSQVHEIHPSHAFLVVPDKAVRARSVPVISITPSLPTCELSMTHPGVKCVHCMQDIVGARFHCAICEAIDICSNCESAGLPGNLDSSDGGHNSSHIMIKIPYPLGTAELQSASRTAKSLWTGRDAATGQRVTSRERRNSLISSYDGTVLGSSTRIGITSALDDVSVTSETDDHGIRCNGCNQNIVGNRYQCAECPSIPRPYNLCSLCEERSYIVHDPMHIFFKFPRPVDRPLQSEYPFIPRLYKAPVGSLSPFNRDDPKAYLKDLFHNSLLCDCCMMKIQGAWYRCAYCGRDLCEVCQEIDTHDNAHAFVVFKSSVDMHMFKRFAELGNDPNGPSPPIIPYPIYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5S8</accession>
    <name>A0A401H5S8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1700680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620656.1">
        <property type="nucleotide sequence ID" value="XM_027764855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5S8"/>
    <dbReference type="GeneID" id="38786660"/>
    <dbReference type="InParanoid" id="A0A401H5S8"/>
    <dbReference type="OrthoDB" id="2804174at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="209" mass="23280" checksum="FD7285DC599CB4DA" modified="2019-05-08" version="1">MTKGALTLDEFLWKRLSELLKEATGFYNTHRHTAPVADIERERIRTRLQQQALKEKSLMAQHVNFTSAPHAVELDYIVTVVACALLNPIHVNCYVMDKGVLKKNGKQDCQGPMLVILEPAVILDTNNKVLTWYLPGILGQARINDYNDATCEINQLLQRTVSQGGNFQTDADLFIAAPGGRFNPDSLDISAGWFAQGHNVSLDINATFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H682</accession>
    <name>A0A401H682_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1702170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620804.1">
        <property type="nucleotide sequence ID" value="XM_027765003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H682"/>
    <dbReference type="STRING" id="139825.A0A401H682"/>
    <dbReference type="GeneID" id="38786808"/>
    <dbReference type="InParanoid" id="A0A401H682"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000006">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="10">
        <location>
            <begin position="16"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="465"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="549"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="645" mass="70626" checksum="E60DB1A5D421A227" modified="2019-05-08" version="1">MPKQGRSSLRNHCFPAFYACYLLKSIRTPHSTATYIGSTPSPPRRIRQHNGEIAGGAWKTKRNRPWVMQMIVHGFPSNLAALQFEWAWQQPHRSRHLRDEEVQAVFSGHRKFNYLRSNVLVARSMVSSHPFNTWPLHVKLFTAEAAKAWKDAELATSNFPLPPGFTCATELEGVDGKSGQTGTERLGPIDVTDGRFTLDYLRKMSTVLASDGDIKCSICCTSIHPRPPDPLITTLCPAPSCTAMSHLTCLSSDFLQSENSQTEIIPRGGHCRSCRTYILWGDVVRGCYRRRGGVVPDPESESDEMEEDEHDNECLPGMQDDNDQLPPAPRRPGTKASEMRRKLVAVKTPRSALRDHDKEEQEFFDLSAVSSGSEDDADEPVSAPVKSFRTKGAKVLGVKAKGKFMLEVSKSRYDTSTVPSSHSDYASILPRGRGKPASRGVSTQPPWERPNGATQLLSAAIGVPGSSESRHLTNATSPSHDLHTHLCTHGSIPKRGHKSAHSRRQKPGSVADLSLAGMATDADAEAAPSSLQIRKSPILNTRSAMSQLTPFPYLPPLSDSDTASNYSYQRSGIDAKGPFCSPDLRTECEDAPVKPQSQDSTTSSKLAGAVSMLSISSPSSPRARVESVTSPQRDQPEHEIIVLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6A7</accession>
    <name>A0A401H6A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium/calmodulin-dependent protein kinase cmkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1702470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620834.1">
        <property type="nucleotide sequence ID" value="XM_027765033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6A7"/>
    <dbReference type="FunCoup" id="A0A401H6A7">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6A7"/>
    <dbReference type="GeneID" id="38786838"/>
    <dbReference type="InParanoid" id="A0A401H6A7"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE89921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="396" mass="44793" checksum="A7B5B6734A18A858" modified="2019-05-08" version="1">MPSTPPTVPCQYRTGRTLGSGTYAIVKEAVHIKTGVRYACKVINKKLMEGREYMVRNEIAVLKRVSKGHKNIVTLHDYFETAHNLYLCFDLCTGGELFDRICAKGNYYEADAASLIRTIFGAVKYIHGCGIVHRDLKPENLLFRTKEEDADIMIADFGLSRVMEEEKLQLLTEICGTPGYMAPEIFKKTGHGKPVDIWAMGVITYFLLCGYTPFDRDTQQLEMEAIVAGDYKFEPEEYWANVSETARNFVSECLTIDPVSRPTAEEMLEHKWLADERPHFVPDPESPHGGPTDLLPHIQKHFDARRTFRKAVFSMMAMKRMSSLVQMSPTHQRLGANLQQYMEESEKEIVNEDRSVLHYGSSSEASLAEDDVSKQSEGSTPLVKAMSKVSIDEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6V0</accession>
    <name>A0A401H6V0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1801350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621024.1">
        <property type="nucleotide sequence ID" value="XM_027765223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6V0"/>
    <dbReference type="GeneID" id="38787028"/>
    <dbReference type="InParanoid" id="A0A401H6V0"/>
    <dbReference type="OrthoDB" id="2754214at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29969" checksum="88E71FDECEB9D1D2" modified="2019-05-08" version="1">MEGFLYCQLFFGPKLQKFALQTGDPDLEGVVVSAHGLAPCLQTLHLDVSIGSGYFSVESPGFLQSFCFSSFQRFIYKSDLPISSEAFLHLFSLPHLIQLDITYEDENQPLMSPLPTTTILETAFPVLKTPSLAAESMRHCAAILKVSRFRHAEKVVLHTQMSEDNTTDNLHAVLKLLPAQIPHDSLKELVITSVGVDGSEEVIDLRCLFLLQKISNLRSLCIDTECRVVVDDAGLETLAKAWPNLQKLFLIQGRSLASFPVGVNPTTLDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5V2</accession>
    <name>A0A401G5V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homeobox-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0104080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608446.1">
        <property type="nucleotide sequence ID" value="XM_027752645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5V2"/>
    <dbReference type="STRING" id="139825.A0A401G5V2"/>
    <dbReference type="GeneID" id="38774450"/>
    <dbReference type="InParanoid" id="A0A401G5V2"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF41">
        <property type="entry name" value="BRAIN-SPECIFIC HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="28"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="166"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="316"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="30"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="168"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="318"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE77533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="536" mass="60142" checksum="9717929AB53F9A18" modified="2019-05-08" version="1">MHSTIPPWARTPPSPPQQHDNSTPERMENTKKPRHRHTPFQLARLNELFERTEHPSLEERTNLAEQLGMETKTVNSWFQNKRASSKKRHKLPSVAGQCELPPISTLLASVSPSAPLRPPSEYDELSEDEHSSRATHFSTSDHNQQQHTLFYTDNPQQKHLFESDNTMPRKARSRPSHAQTDELRKVYDVNQHPSKEEREELGRKIGMRYQSVTNWFQNQRSIAKKRKEEEETQAALAAGAISSKGRTYTSFPPAAGAAHPSLAVPPSSGHPSLPPLTVPHVPRARRSVSAAPAASRPTSPRASPYRAAADRVLVATHLRPRRTRPEPHQLEALKKLFRRTETPSIEERGALALEIGMEVGKVTNWFRNLRQTARRRAQKGGSGEEDDDFEMDMDMELDNVSLATYNDSRSVSRSATPSQLATSSATSLDVPMDLEDVRVKVEQADKHRRIYAHVLHAHSNSDMGSEEEYQEAVTPESSPPPSAYPPSAPRIRELQIAVDALAYAETEKASTRLDTGVKVEDALLLLSFHQHVALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G693</accession>
    <name>A0A401G693_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0105680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608599.1">
        <property type="nucleotide sequence ID" value="XM_027752798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G693"/>
    <dbReference type="GeneID" id="38774603"/>
    <dbReference type="InParanoid" id="A0A401G693"/>
    <dbReference type="OrthoDB" id="3195323at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109248" checksum="A38432471F2A5F56" modified="2019-05-08" version="1">MSSTMGPTSQAKSWWSRSKSKDSSGLTPKRSFSNLVDDEKHMRSAPRKLTKTKDATAGLKFNTLASAMGFRSKKLPSLAIQDPPTNTSVHRSTSDNSAPSPFYTNRPPAKSVSTARSSEYDGDEASDPHDIPEPRTPSDHPRDRMSYQTSVLTLSEMDPFAAGGVVIQQSQDSYRQSVFSDSSLLEPHRKRSDFVSNNRTSYASSSSNSHSYLSEPRSGKMSSRITRSSRTPSDTSMKQEPRRQETLFVDDGRSVASAEPRSIRARLKTPSGSNSSCSTVTPGDYRNRLSEPPPGAPHPHPRARASDPHGFHSPLGAASPSLSPLTFAGPSVTPPPGTDSPVSPSSTRPLVLVRKASASIVHMPPPSLAPPTANLPPPPLSSFVAPEPSSSADNLSIFLSNPPSPSTSSVSLAPSFEFSVEDSAGDAIGHLMQDVYPPLPEGCSRQSKGNGRRRHIDAESSNSSMRRLPPPHGDYMHPDQSMSAHTSPKLLKKLPSQQSLLGKHYSEQSLTSSVVSLGQDEYANWRGSSGSLSSSKTPRKQRSFHHSRLPLPPLPALRHANSYNHSSTPPEGRLPTPSSPPTTDQQQRKSGFTHTTPTSARKRLFSGSSSRRSTSSQGPASPATSAEDETRSVINTDEPRTQSRSSSSAVQKVMISFGNFGHPLSLSTKNACVAPSSFWSEPGDSMSSSYGDKSASQTEYTPQHIIPPADMLKLEQQLAEEAAQRDREMDQEHKPKLELQPRDFGFAFIGRRRRSDSKLSGSRTSSIMSSVSAATLPFGSEHHILGESSTSGTSSLRQTASARPSSTTNHNGKARELSADSSRLPLRSSSLMAKSFPKPPTSIARPSTAQPSISSPTSPTFSAFTVSPGRPPTSLPPPPRSRPSRENQPIQDDPVLKRSSIVPLHPLSPPPVHNRIRRPHTATSDSRNVQSLITSPPSSFDQQKVSKRRSIMKKPSFLDIEDELDATTENLMEMDIDVPPASPVMEGSFLDMEHGRDSLDTDASCDSGFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6N3</accession>
    <name>A0A401G6N3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0107000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608731.1">
        <property type="nucleotide sequence ID" value="XM_027752930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6N3"/>
    <dbReference type="FunCoup" id="A0A401G6N3">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6N3"/>
    <dbReference type="GeneID" id="38774735"/>
    <dbReference type="InParanoid" id="A0A401G6N3"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="1">
        <location>
            <begin position="18"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="191" mass="21224" checksum="D12FC40C4D26248D" modified="2019-05-08" version="1">MRLIEHEIPRLVAYRQLFVPPSSSTPLIVRSISFGGEEHPAVQKRTIVVPISHLPLRDASAIHKFKVLAGPRWSPEPPRDSGIGLNEGDEEHGYFKISCEDFPKAAMNLKWASDALDRMLAEANNGEDKFADVPLDTRHIESKVRKAKKGDHVYGRGGKRPSIRDFPKEWLPVLRSATPEATEVGGSSDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Z4</accession>
    <name>A0A401G6Z4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0108220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608853.1">
        <property type="nucleotide sequence ID" value="XM_027753052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6Z4"/>
    <dbReference type="GeneID" id="38774857"/>
    <dbReference type="InParanoid" id="A0A401G6Z4"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="8">
        <location>
            <begin position="365"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="578" mass="64670" checksum="590D9F34176F602E" modified="2019-05-08" version="1">MSSPTDHKDRRVRSLLDTTHYDILYSLPDDHPLAVALRTYVLALSLALGPALLPFVTSPKARINGLARLKNVLKREFAFAGFAFAMTVGVGCGAAIRHVWNTACEPSDVNIRCEDTNLALCLAKVRRWLSSVKYVHRTFISNFISSALAITLLHSRRPNYRPTVERAEIPLLPHISESSALHKSLSLGPRPPPTLDLTLLILVRALDFIVQATLGRIARFDELDPKRTPEQKEKRRRLLHSRLDALVFWMSSARIMWCFFYQPERLPRSYNKWIMTLANIDPRILATLRALRSGDWSYRLHYSTQPDLVSSLSRDLGYPSIWGDYALLPAYGGPQADEAWKLMGVTTRKGLGGIPCELVHGSVTGGSCTANAVIRGVQAFAEALALYTPVHFLPIILTRPQTLLHLPKFASTVLSLLRSASFLSAFVSSIWLSVCLTRTLVLARLFPAVSHDFWDGPLGCTFVGSLVCGASIWIEQGRRRGEIALYVLPRAIRACLPEKWLKGGSTTFRYAEWLAFVLSLSTLLSAAIHQPDSLRGLSRWILTFVMKWPKTGLRKRELQENSRPDAPVEPPPMHRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7U3</accession>
    <name>A0A401G7U3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0111150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609145.1">
        <property type="nucleotide sequence ID" value="XM_027753344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7U3"/>
    <dbReference type="STRING" id="139825.A0A401G7U3"/>
    <dbReference type="GeneID" id="38775149"/>
    <dbReference type="InParanoid" id="A0A401G7U3"/>
    <dbReference type="OrthoDB" id="6244550at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45924:SF2">
        <property type="entry name" value="FI17866P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="67"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="873"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1012" mass="109249" checksum="5E633CE912D23895" modified="2019-05-08" version="1">MNDRVAAGIPKPLPSPGRDEKLPPPPPEANNAWNPPAPPKVIQNPDPEELGIPSPSAPQTSLDRKPKKSNPLNDLIDSEKVYVDLLTGIIRKVASAWSRSNLPPPELDTMFRSVETIHKANRSLLAKLKQIGTDPSSPKALGDLLMRWIDDLETPYTTYSSKYCCGFDAWEPIQSNERLRTVLAMFSSTHPPPLPASAPLHPAEPPIWTLDELFLLPKGRLKYYRKLYTRLLKSTTPGRSDHRLLSGALEKLERLIATVDERTEVKVGGVPVTQLPRETEDEVVIDMRSHDSIMPLRSFTNGPEQRASDSTHGSNSTSSGERRSNDTAPTSEDRTSVSTLSMPVTDLERRLRTERTLDIFTMQPKQVRLQMAPPTLHYSREVRFSADVVVSVTPRATGAEVVHRRGHVFILTDLLLVCERMTSQERVQNGRDGADMWLLYPPLAGKHLRVVPISSSDTSLSVVIMRKETVIFHTTTPALRDQMVTEFRECIDAATILLPSSKNAAPPPPVPALPSMNGLPQHPRPLLSKDLRQRSTSPPARALSPPRGPGNRYAPQPPYNNPDFDPAIVNGVSGLALHTGHVQTVSTNQSSPMYPPRSSSAVDEPPGQLAHGSSFGPGQMTPPQPHYGALGGQGPQSFTPGQLVRGPSFGSGQVTVPQPVMDGRGPPPPGPLARGPTVGSGRGGPPQPSFEPGQLMPSGSFNPGQHPGQHPGQLMSSQSYGPGPGQMPPPRNPNFRPPPPDSGFRPGMGLPQGPGQGAPGGPPGGPPLSGLPGHPSPYGQPQSRPSSDSSSQGGLRKSPSSRSLRSQPDRTPASAPPVPDYPLDLTDLPPPRPGFLPRTSSSSSLYSLPSSLYAQPHQTLQSAQMSVRSMSIAPSFVDPSPPSSPVEETPPQLGPTTSTISAQMKCKVFLQQYHSQWKSLGTAKLKLYRESPTNIKQLVVEADNRSKSVLISTIVLSDGVERVGKTGVAVELSDKGQRTGIIYMIQLRNETSAQGLFDSLLAGSDRFLPDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Z2</accession>
    <name>A0A401G7Z2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L32-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0111650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609195.1">
        <property type="nucleotide sequence ID" value="XM_027753394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Z2"/>
    <dbReference type="FunCoup" id="A0A401G7Z2">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7Z2"/>
    <dbReference type="GeneID" id="38775199"/>
    <dbReference type="InParanoid" id="A0A401G7Z2"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="127" mass="14687" checksum="AE9932D685BAB05E" modified="2019-05-08" version="1">MVKVPIVKKRTKPFKRHQSDRYHGVKEAWRKPKGIDNRVRRRFKGQLPMPKIGYGSNKKTRHLLPNGLKKFLVSNVREVDILLMHNKSFAAEIAHNVSSRNRTLILERAKVLGVKVTNAAARLRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8B0</accession>
    <name>A0A401G8B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutathione transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0113180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609343.1">
        <property type="nucleotide sequence ID" value="XM_027753542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8B0"/>
    <dbReference type="FunCoup" id="A0A401G8B0">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="GeneID" id="38775347"/>
    <dbReference type="InParanoid" id="A0A401G8B0"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="748"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="814" mass="91792" checksum="ADBF102F33B9390B" modified="2019-05-08" version="1">MEAPTSSVTVTFPQFLRRRNPIPDVPEDVDYVMQHLNDPNWDLDRASPRASIDSLELDDKSGVITSSRLSIRSSNGDSDSQVDSSYRTSSGKGFDVEEYDDESPYAEVRAAVANTDDPSMPVNTFRTWFIGIVLAMVLAIFNHFFGTRYPSVAISALVMQLVALPCGKAFEYLLPTTRFTTFGYTWSLNPGPFNIKEHTLITVMSNSIYGDVYVSSVFVTQQAFYHQALSIGYQLTLSLSTQLIGYSFVGFLRNFLVWPSSMIWPGSLVSCALLRTLHKSYGKKEGRHMSRERFFLYVMIAATVWYFFPGFVFTALSMFNWVCWIAPENPTVNALFGYASGLGMGFLTFDWAMISFMGSPLVTPWWAELNIWVGFVICYWVIAPIMYFKNALYAKYMPISAGVSYDNTGMTYVVDAILTNGVFDLEKYKAYSPLYMPTTLSLAYGVQFAAFTAVIVHVLLWYRRDIFRQFNRSLGDERDVHARLMSVYPEVPWYWYATVGVVALVLGAVGIEVYDTGMPLFGLLVALIVAAVFVIPIGIIRAVTNQMIPLNVLSELIGGYIIPGRPIAVMLFKTYGFNSVNQALSFTADQKIGHYMKIPPRSMFMAQVIPTIMSAMACIGVQYWQFAHIEDLCSPTQKDGYVCPGFSTFATASVIWGGIGPKRIFSAGALYHPMLYFLIVGAVLPIPFYFLAYRYPHSFWRYVNIPVIFAGLGVMPPATGVNFSAWITVGCFFMWFMRRYHFFWWMRYNYILSAALDAGLALGLILIFFCLQLPKNGITLNWWGNTVWTKTFDALGMPFYSLPPNATFGPQTWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8V4</accession>
    <name>A0A401G8V4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dynein heavy chain tail domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0114770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609501.1">
        <property type="nucleotide sequence ID" value="XM_027753700.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8V4"/>
    <dbReference type="GeneID" id="38775505"/>
    <dbReference type="InParanoid" id="A0A401G8V4"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain tail" evidence="2">
        <location>
            <begin position="366"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1293" mass="148329" checksum="12D105B2AE5889B2" modified="2019-05-08" version="1">MPRVRRTWDGARRQATVGRGWKGDQTRPPLLLRCCSLSRLSFLLDDDDDGLDFFLTRSLLASDAWFTTYDQQYFSRQRRPLPKVLSWTSRSSFKSRSTVSLTVSHGDPVSSSPPPTAMAAVDSAYASPPHTNGATTNGNGALHDGLVEPSISFQPTAFRSYLLALLPPVLGASAEELESLFDDEFDERVSRFAGEGGGVIYVVKRKDDVDVEDIPPTYTYQLTHQLAYDSSHVTTLAIFKRSPILDSTTPLATQLHILNLFGGDETPYESLHAVLSCAVKPWFDAFVGTRGGGKDGDSKMGIPMTKKKFAELELSLLHLQQNVEIPETHLIIHPVIQRTVEQAHTAGTRPNISDIPSKLLNDSSFLNTLHGHVNQWIKSIQTVTKLTRDVGSGTASQEINFWLSLERALEGIENQLRSEEVNMVMECLRNAKRFHATVSFIADTGLKDATDTVHKYNQLMKDFPLNELLSATDLDKIQESLVLIFGHINRKLKLSPYPIRRALPLVEAISRDFNDQLLRVLTSHRLLYTPYDTFERLLSQAMTIFRTWDDNIKEFTNVAREVTRKRAEKFIPIKVVPAHAKLQDRVRYLRDWRKQHEQLAVMTGPTKGLSGVGMEMGGMDMEAEVKDAYEVMKRIDVLDVSLEGGEIWVAAENAYNERVARVENQIIARLRDRLGTARNANEMFRVFSKFNALFVRPKIRGAIQEYQTQLIDSVKEDIKRLHDKFKTQYRFSEAYHMSQMRDLPPISGAIIWARQIDRQLQTYMKRVEDVLGKGWELYAEGQKLQSESTAFRKKLDTRPVYDAWLHDINRRDMGVNGRLFEIVRLRGGGFQLAVNFDPQIITLFKEVRNLLWQNFQVPHAITNMAKDAKRVYPHAVSLMETVRTYGQTLDLVENNQGIEWLVAEYRNEAQRMVTRGMNIRWDYFVNQYDTARYVSSGDARDNRHIQFVREFASVVSVLQDKTNNVIDLYKDIIRAVEELVTCPYTPEAFTELLGRIQADIDRLNLEGYANLEYWVAELDKRIEGIFLQRLNNVIQLWCGEFDRSEDPDGRRDTLVLRDITNKRRGDKRTKEEKSLEGSISLKPIVHEIRIQNQVIFLDPPIEYARQTWIRQLHDWLGVVCRLRRIQSSRYEIGLQMQGSVASEATYTSLLTHFSDATLERPFALIENKVQQLKDYVAKWLQFQSLWDLEAEYVFNRLGDSLAHWQQLLTEIKKARSTFDTSETQKSFGVCVIDYEQVQARVNAKYDAWQRDILSRFGIKLGNAMKEMHATILKARNDLEHHSIEGLVGGARRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8W1</accession>
    <name>A0A401G8W1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0114680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609492.1">
        <property type="nucleotide sequence ID" value="XM_027753691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8W1"/>
    <dbReference type="FunCoup" id="A0A401G8W1">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8W1"/>
    <dbReference type="GeneID" id="38775496"/>
    <dbReference type="InParanoid" id="A0A401G8W1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF14">
        <property type="entry name" value="ARF-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="382" mass="40962" checksum="2C6EC5185A688E01" modified="2019-05-08" version="1">MSRQDKATTERHAKTLRELLKKPENKVCADCKRNDPRWASWNIGVFLCIRCSGIHRSMGTHISKVKSVDLDVWTPEQMASIQRWGNRLANLYWEAHLKPGHIPADHKMESFIRSKYESRRWALDGPPPSDPSVLETQAAQSTQSTQAIPAVTAPSAPSSGSPSVTPSVASAPRPSVTNRQPQPHQLLSAGIANRTHQAATHPALSTPDTQLQQPAASASVPQATPANELFSLDFHPPSESSTPTAAPAKKDVKQDILSLFSTPAPTPAQPAFPQFAQADAGWGNFASQVSPQPQPQQTSMMGNAGVAMWGASSGWKAPAPPSQPSLWGNASVQPPQQQQSLFTTSDVWGTQSAVAATGDLFGTSAGMQKKDDAFGDIWGGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8X3</accession>
    <name>A0A401G8X3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0115150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609539.1">
        <property type="nucleotide sequence ID" value="XM_027753738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8X3"/>
    <dbReference type="GeneID" id="38775543"/>
    <dbReference type="InParanoid" id="A0A401G8X3"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="10615" checksum="778967A1D6EF43B6" modified="2019-05-08" version="1">MGRHVIEQGAIEIAYGTDHATGYFLSVVDARLAWSEDATDAVNAVAEGLCAHGGGSYFDLHTGPGGFGRKVDVATLMTFWQRYGVPAQHVQLAKLGNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G903</accession>
    <name>A0A401G903_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arsenite methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0115340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:23808"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:69432"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27130"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:183640"/>
            <dbReference type="EC" id="2.1.1.137"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.137" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609558.1">
        <property type="nucleotide sequence ID" value="XM_027753757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G903"/>
    <dbReference type="STRING" id="139825.A0A401G903"/>
    <dbReference type="GeneID" id="38775562"/>
    <dbReference type="InParanoid" id="A0A401G903"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030791">
        <property type="term" value="F:arsenite methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF8">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="320"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="422" mass="45154" checksum="009D950B5CD1B1D8" modified="2019-05-08" version="1">MSNSEETLVEAVRDAYSAKAKASVDKSYVHNVASAFGYSVEELQALPAGANLGLSCGNPIASASLKEGETVLDLGSGGGIDIFLAASKIGPTGKAIGLDMSEDMVALARRNASKQGLKPPHVAFVQALLTEPLPIAANSIDCIISNCVINLLPGSGKAKIMQEAFRVLKPGGRIALSDILAKKPLPENIRNDLAAYIGCISGAIVLDEYRGIILDAGFSDPMFVDKKADLNVYFEPGSTAGFSCCATPSSCCGPQEPNAPNFDSNEWAGSYQIYAVKPPGEGQTESPEPLLDWWLPFPATKSDVPYITADELASMMKGSERKDYAVIDVRQTFSGGRVRGSLHCPPQNFFDELPAFVEKFGQTKQVIFYCGLSSGKAPRCSRWYQDRLNDSGIKTSAAYILKGGIKGWLANYDGQEELVDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G979</accession>
    <name>A0A401G979_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0115840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609606.1">
        <property type="nucleotide sequence ID" value="XM_027753805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G979"/>
    <dbReference type="STRING" id="139825.A0A401G979"/>
    <dbReference type="GeneID" id="38775610"/>
    <dbReference type="InParanoid" id="A0A401G979"/>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="194"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="310" mass="34104" checksum="026C3168C2024F50" modified="2019-05-08" version="1">MTGIMQVDGLKGTFPEQAHIPDRSQGAGADAGRAGADTALRIHDEPVSPTEDGIAVSYSSWDSHRDESPSDSSKDTESKDVPSVSAALNAAFGSPAVPEDVADTAGDAPEHPLAFNTHPPSPPPWEHINPPSSGAQRDGFSSANTRVVHDFTGKPIRSRPVVPFSSYYFGPPPPEAAYGTPPMGQIGMHHPREVVRIERDYTGGELIQFAPTYPLELEGRLTPTQFLETVNAINERLIEAHSLRHAAIDNALAFFSLQLSRLVFMSHYDKEMQRLQSLIQDLNTRLYNPVGLHIRWPRKVAFLFLEIEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G984</accession>
    <name>A0A401G984_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0116370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609659.1">
        <property type="nucleotide sequence ID" value="XM_027753858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G984"/>
    <dbReference type="STRING" id="139825.A0A401G984"/>
    <dbReference type="GeneID" id="38775663"/>
    <dbReference type="InParanoid" id="A0A401G984"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="119" mass="13901" checksum="639CCB593BF1CCA3" modified="2019-05-08" version="1">MFHVHSGTRFTPSGAEDVFSSPRTVKFHCYSYRPRGRFDACFRQLIWTAEKPSKKFYIPQECFDIIFLQDKIAVLCASGLKIVTLDDLQIVSMPDFEDPHLVAIYRRYDSHRPLGIFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9E8</accession>
    <name>A0A401G9E8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0116870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609707.1">
        <property type="nucleotide sequence ID" value="XM_027753906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9E8"/>
    <dbReference type="STRING" id="139825.A0A401G9E8"/>
    <dbReference type="GeneID" id="38775711"/>
    <dbReference type="InParanoid" id="A0A401G9E8"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="262" mass="30112" checksum="D6D35672FA0DAE06" modified="2019-05-08" version="1">MARRSSHPAVHSPYFPAPPFRRRRKKSPKILYTSPYFSPERVQRCSAGSGTPAEGPHNEYQSLLELSGFKYYSQDFLAAFQELYFAKPILIQDHVAHDPWKFLRAVMLLNRPRGAKTVPVFFNLMKPQDFAVAPQDAVEEIIRTLGLSNMPDLLRKWRCKTNVYSSIVADSVQNVVAEETGYKRTPASHLPGCGPYALDSWRIFCAGNEEWMSVLPKDKELKKFLCWKWAYEEFHQWDPELGLGNVITLDYVRDPTVLLPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9K0</accession>
    <name>A0A401G9K0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609750.1">
        <property type="nucleotide sequence ID" value="XM_027753949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9K0"/>
    <dbReference type="STRING" id="139825.A0A401G9K0"/>
    <dbReference type="GeneID" id="38775754"/>
    <dbReference type="InParanoid" id="A0A401G9K0"/>
    <dbReference type="OrthoDB" id="2793259at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="124" mass="13786" checksum="710D12E0EF9F4BA1" modified="2019-05-08" version="1">MSSNLLNRSFTFIIPKFHLPAHQESCHVAYSFNLLPWVAQTDGEGVEWGHATHNPYASSTKEMGPGSRRDILNDAFGNSNWRKVSNLASTFLAKVKTAVQERCEHVCTFHDFNAVMTAESSAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Z0</accession>
    <name>A0A401G9Z0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0201680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609884.1">
        <property type="nucleotide sequence ID" value="XM_027754083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Z0"/>
    <dbReference type="STRING" id="139825.A0A401G9Z0"/>
    <dbReference type="GeneID" id="38775888"/>
    <dbReference type="InParanoid" id="A0A401G9Z0"/>
    <dbReference type="OrthoDB" id="3050970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="331" mass="37141" checksum="5706B3EB0549088E" modified="2019-05-08" version="1">MQTFGNTSNLQFALPHAVERKHSAACLFSEVEGHPQPPRRCTGHCGATTPLQPRTPTLSSHLGDTARLREVNSLALLPRPRTPLALFPFVLQFSRSPEEPTRGPRGDTAQLREVDGPTLAPPLRTPLALRPSVSQIQRQDTIEIMSNIQYHYLDLVGAVVRQGSFIDKMYAFGWTEPGYFNDKEDELVLMHATARYHACPALLYRFLDLMSLSLMSFFVPTLDIDLVCDMLSAMHASEHNVIGAEKFAWRRQRDVEHVRAGRMDANAFERGRAHDTAFPMPVPFYHPIMTCVIIANPDLLVRTGSRHMNGQALFVVSRRSDLLVPCFSTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA52</accession>
    <name>A0A401GA52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0202630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609979.1">
        <property type="nucleotide sequence ID" value="XM_027754178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA52"/>
    <dbReference type="STRING" id="139825.A0A401GA52"/>
    <dbReference type="GeneID" id="38775983"/>
    <dbReference type="InParanoid" id="A0A401GA52"/>
    <dbReference type="OrthoDB" id="3243310at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120062" checksum="B3DDCE422A01D95E" modified="2019-05-08" version="1">MSGQSPQRNRKTLLGTQGPVQNIAPRESTPSPSFRERQRTAKAHLLPIVPTVSQILANQSQSIHQGQQPSPTASISSHQSRRSPPPTTRISPTASKMAAPTLPRDRSPERLNSPPPLQHTVSQPILPHMVPLPPAAPQHSQSQSSVLSRVMTDPHHPRPVNRVPPPNFISQYRTVDDEWQVTDELMAEIERADYQAAQGQLSHPAGTSGVAYAGGAASSGAGLQHQLTMNTAAKDPAVERVRATDRSSPKDQDSSGPPAVAKRQTRDRAQTVSSQLPVHDTNGANRTPEYRGSPQYATPMSSPNERSAGYTQYVPEGYQAGNSQGPTPPALRKASGQVGVVPNQVAAEPRSTPPAASKLASHTPPLQAMTQRPPDRSLPVQEEPEEDHDRDDHDNRQYDDTRGTPSPASDVYPDGSRFDVLREHAAKTVHTTTDDDEETLNEEDDDHHHRSKSGEESDAGFTPRSPSTTLPERPRDAPYAAGGGQYMPSGGQYVQPSTEYQKTVRAKHRSGSTDQLGMRTFDPAMFEHTVNSLRSDDAPVNGQRQQQSPPQQQHSPPQPPLPPQVQSQSLPPPQTQAQQQIQHQMESQMQQMDNSRHYGSNHVQDQRMTYPGMPHPGDMQGLIDDSTSVYLRAYLQSPSSRPNAPIPPTPQSQTAAPSPIISAQSELEHRQIGSPYPYPFTHIRRTTVAAPTQAPSSSYDLNDPAVIREQLALQMQIYALNNGLATPTDSTFSPSSTPFPGPGYNPWAFIPTMAGHPNMGGGSAMSIRSSPSHEPVHLPPPPLAMRGRGLRRRDQTVNLRQQGGRDTRRVKPPPRVESTQPRETSPEPSSGEETAGEERFVDQYVREGEEVDWAHVRGHENGHGNGNGNGNGNEIENGEVADNPDDEGDWVDEDEDGEEEDLLDLEFHPTFVSNPQKRRRRWETRWDAVTQSFQSLDRETDATLILLASPAHSSKLYALTSRSIRRDSALLNSSKLTAIRTSFNHLASQRRVARSQRISLFDRLHLSSPSIRGSPGSGDSREDDLRRALEAALGSLGEMGKIYEQRETRWRDELRQLSEDRDKVELLLHQALGPSGLTNGNGHTDDTNDRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAG6</accession>
    <name>A0A401GAG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0203620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610078.1">
        <property type="nucleotide sequence ID" value="XM_027754277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAG6"/>
    <dbReference type="STRING" id="139825.A0A401GAG6"/>
    <dbReference type="GeneID" id="38776082"/>
    <dbReference type="InParanoid" id="A0A401GAG6"/>
    <dbReference type="OrthoDB" id="3063971at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="505" mass="57177" checksum="653D134CD9E05510" modified="2019-05-08" version="1">MQADFDRSLFRSEPTAEDILAANAQIQKHELTITSIQSQMNQLMLDLQRLRKEQLKHVDEIRFHKGIISLARRIPEELLSKIFEHCIEDGWTRAPIVVGHVCSMWRLATRAPRVWSRVYVDCDSPVVVDRLRFWLSRACSSPLHITITASSMVASSTFTNVMAILGSRADQWRSLSIDIPTLYELSSCIQECDFNMNNLAELWIRVEILRAGNPNDNNADALELKSFFRLARAPKLHAIRYTCNVIPSIPIFPSHIRDLHLTTFESPIWRPLSAASLFVLLEDLPELQCFTMSMPLMYARPFVPVPDFTRTVTLSKLESLTMYGPTDLNGLLSHLLVPALRRLHLRSLEDLGYRQHSLGPSLLRLIENSVPPLELLELHDVDLSPEYFARCFTATPVLRELRLHESSISDATLNLLNGPSGLCPRLTRLDMRWCGLLRGTALVDLVRSRHVEPGAPSGEVGVSKSDLIAEVAVINCCFVGERDVLDLARMTTCRVVMRDGDDYCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAR7</accession>
    <name>A0A401GAR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SCP_0204530</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 25">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610168.1">
        <property type="nucleotide sequence ID" value="XM_027754367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAR7"/>
    <dbReference type="STRING" id="139825.A0A401GAR7"/>
    <dbReference type="GeneID" id="38776172"/>
    <dbReference type="InParanoid" id="A0A401GAR7"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="22">
        <location>
            <begin position="372"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GBE79255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1257" mass="139523" checksum="FA8F2C7B9057E580" modified="2019-05-08" version="1">MRLSILPESQQLARDNWLEWKRRILAICGPKCLVGHLDGTKTWPNYPTPLIDEWEDRDELAKSTITLNIRDLIGSSVDLDETAHEIWTKLTQIRENRRKQPATWKHAPRAKQGSPADLAARAKGGSMNAANNASANLTSASTSHHPTLFYDYNIFLANAFITAGSICGSLNCAFIDSGVTHHYFRDRTNIVDYLPITPIVGNTAKEGSTFTMVGVGTVRIQVEINGLKSIVTFQNAMHAPDLSANLISLSRIDRSGGAAIVENGILKIVGDGRSILEGRLTDGDLYEVHFQHVDLPILSTLPEVHIAYDPRAVAFSAVTSGGPVSIATWHHRLGHASERTIRAMASQQVVDGLILTDEKPLGKCEDCLKGKMSAAPFHESQVEEEVLERVYIDLMGPFQAKSLGSAEYVLTIDDDASSYSSIYLLKGKSAEETLKHFQDFHHMAEHQTEYKLKCVCSDNGGEFMNATWDKYLLKHSIIYESTTPYTPQQNGLGEHGHRTLAKHARAMLFDAGVPNYLWGEAFITAAYVKNLTASSCQCGLTPYEKWFKHKPNISHLHAFGSIAYAKLADETRFKLDPKSVKCILVGYTGDANYRLWDPMSGPHGTTFCSHKVVFEEGPGHRSINEEGVVNIDLPNIERRVPAPLPIPPPVDHVPAVDDPHVGRDPADIPMEHLPEHLPAHPIPQALKPHCSARTHIPTCALQESQESEAREQAAHVRGEAWADNSIALNHDCVGAYMAMLIQGEKQKPTAFVHEGGVTPSTYKEAGQHADIWQPAMQTEIDGLHKIGAWQLLPRTAGMNVVGCKWVYARKFDETGKWKAKARLIAKGFQQILGIDYFETHASVIHFESLWMICAIATFNDMEMGQDDVEKAYLNATPQEMIYMEQPPGFVDAEFPDHVCLMQRSLYGFMQSGNDWCVRARQDDNGVMVTATYTDDISSCTDTVDGLGRIRGEIGTRYHLSGGGDFKYMLGVIIKRDRDVRTMRISQHPYAERVLKRFSIQYANPVHTPLEPSIKLGLATEPITSDEALEMATVPYREALGTIMYLAVTTRPDLSYPVQVLSRYMANPGIIHWKALKCVLRYIKGTLDYGITFCGPPHPLSTLQPTIYSDSSHADCPDTARSTHGYVAVMASAPVSWSSHRQDVVTLSTTEAEYIAAVHAGQTAMWIAKFMDNIHNPVTLPVNIRMDSSGGESLAKRSANFTRVRHLHGRYHWLRDAIRLKEIDIIHIPGADNPADIFTKSLSQPVLHKHLLFLGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBA5</accession>
    <name>A0A401GBA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">chitin deacetylase</fullName>
            <ecNumber evidence="12">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0206450</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610358.1">
        <property type="nucleotide sequence ID" value="XM_027754557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBA5"/>
    <dbReference type="STRING" id="139825.A0A401GBA5"/>
    <dbReference type="GeneID" id="38776362"/>
    <dbReference type="InParanoid" id="A0A401GBA5"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF135">
        <property type="entry name" value="CHITIN DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019442015" description="chitin deacetylase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="16">
        <location>
            <begin position="154"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE79445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="457" mass="48841" checksum="D9FAB1B352D49A8F" modified="2019-05-08" version="1">MVLPLRCVLSVITALPLASLATVIPVASNFHPHEHPTLTKRLPGVWYQADDSPAHSLFHRNKLSDRQTSPTVGSSTWSAAYPEDTPDSNQLPQAWVDALDAAVSAGKIPSIPVPTMGPDGNPVYPDGLDPTSSEVCSGTYQCYIPGELWNAPNGVIAASFDDGPLPPSTQLYHFLSANDVHATHFMIGLNIIQYWEEFNLAVANGDDIAVHTYTHPYTTTLNNSMVLGELGWTMQLIHDSTGGRLPKYWRPPYGDTDVRVSAIAKEVFGLTTVLWNNDSADWTIDTKGGQTQQQVEDSLTQWIEGPKSPGLIILEHELTNGSVNAYMDVFPLIRQNGWDIVSVAQLDGLPAYQNVAPGSGTVQPVTQVIAYNPTSAAPTSSAYVPPAVAANANLSSSSSYSSSHSSSFSYPSSASQSATPSTHDTQMKNGAVLFSPASSWSMAGLMTGIAGLAALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBB4</accession>
    <name>A0A401GBB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0206520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610365.1">
        <property type="nucleotide sequence ID" value="XM_027754564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBB4"/>
    <dbReference type="FunCoup" id="A0A401GBB4">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBB4"/>
    <dbReference type="GeneID" id="38776369"/>
    <dbReference type="InParanoid" id="A0A401GBB4"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="197"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="850" mass="92311" checksum="7F3B54BD72323BE5" modified="2019-05-08" version="1">MAAVNLQMMATNVPFDFLPGQPHSRSASVSSSSSHSPSSRPQSSQGGVLRASAGDHTRNTSDTSHSSVYSLSSSDLASPGDSPPNHNVSNPSLKGPLRPTHIRARVAASPYPRDTESVHSSSSETEDISMYLGAAPPDYHPMFGGQQTMAHVQETMHAAGAFGRMTLSPDHALEKLAANVRAATTTSASDRAKQIFVQAWLTANYSPYPDGNVPRQGLYFSYRRVCDQYGIPHINTATLGKAIRLCFPTIKTRRLGVRGNSKYHYCGIRPATSAEAEFLQDYIRKSNNNAAQQSVNAARMASEQAEASRGGSDEEEEDESEGPSSGNSKRNSLNLSNGAKNPNIFTDEKTPTATSLLQQAQARLPGSNFPTQAPIRRHASQPEGTITVQPSSAVGGAVPLIALNQPISVRQMPHFPSIEEAIGANSTIPQGIAAREVWRWFEDHLDALLESIRSFRFDQFELNLRTFWSNLNGSHREVVHAPAVAGLMAKADAIVYDEILEILRSQTLSPIPPASLAGLRQLADKMEKILLVALEGYGSTFVEPKVELGARFGHLVLRFLDIYQVAQALNTVLTNQKQLLEMRRSWQKIDFESVRNQSALVCNCRHEDLVQLLEMEFVTVLDGLLKSADPIRDVMAWADKCCDRLMGGRNNGPEDRPTMSSRSVLIRWGYVTSQVMRDLTIRSDPAFGAFQILKLFLDDWIALNVLRSVALSTNSVAASVEPVMQQQFFLSEDYSNSLDVRPPMANTPTTSSMLAALQQDTFGSLDPASSAFGSDAFGSLSYMDTSSTHDDSMPVHSSGLSFPEYVTGSGSFDVGAFTPQDLGVGASGTPPPSSSEPTPEEEPELVKSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBW3</accession>
    <name>A0A401GBW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0208490</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610562.1">
        <property type="nucleotide sequence ID" value="XM_027754761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBW3"/>
    <dbReference type="FunCoup" id="A0A401GBW3">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBW3"/>
    <dbReference type="GeneID" id="38776566"/>
    <dbReference type="InParanoid" id="A0A401GBW3"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000006">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE79649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="532" mass="58559" checksum="63CE6357B891DF8C" modified="2019-05-08" version="1">MSSNIKASNATKPRKRFIGSKHATPTKHGMSSIVANQIPEDILTDVQLNAAIKQLPSNYSFEIHKTIHHVRKNNAQMVALQMPEGLQMFACTIADIIERFTDALTVIMGDVTYGACCIDDYTAVALGCDMLVHYGHSCLVPIDQTTIKTLYVFVEIAIDSSHLGQTIRLNFPNDRRRFHEALLDSEETDKDIPAGNPLTRGTHLRIEGPDSSHEMNDTGVDSPNGLLSSYEPTRLALVSTIQFVAALSRLKDDLTVEYVDPQLAPTRIIEGSSNAVQQTSAVGRPRLWTGKYDATIPRSKPLSPGEILGCTAPQLGDVDALIYLGDGRFHLESIMIANPSVPAFRYDPYSKKLTRERYNHTEMRTIRDQAVRTARQSIDAFSSSPSPIGDMAVSSQNNTLLWGVVLGTLGRQGSFRQLQAITHQLSTSRTQIPYMPILLSELSPAKLALFSPHIAAFVQTSCPRLSIDWGYAFDKPLLTPYETAVAVGKAVGWMDDSHADETSESGARKDAYRMDFYEAGSPWAVARAKAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCB7</accession>
    <name>A0A401GCB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0210200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610732.1">
        <property type="nucleotide sequence ID" value="XM_027754931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCB7"/>
    <dbReference type="STRING" id="139825.A0A401GCB7"/>
    <dbReference type="GeneID" id="38776736"/>
    <dbReference type="InParanoid" id="A0A401GCB7"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="359"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="7">
        <location>
            <begin position="579"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="547"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="665" mass="73458" checksum="6943B027FB95E3B3" modified="2019-05-08" version="1">MPGATLSAPPFPQPLSLPLSQDDLERINAYLHDLAPEDILRWAIDHLPGLYQTTAFGLTGLVAIDMLSKITKSPPPLIFIDTLHHFPETYELVEEVKKKYGSSIHVYKPEGCDAVTDFEKKHGERFWEVDEQTYDFVVKVEPARRAYEELGVKSVITGRRASQGADRANLSPLEVDDTGLLKLNPLFAWTFPFVEWYIKENNVPRNKLLDQGYRSVGDWHSTVKSGEGDAGERAGRWAGKAEKTECGLHVDYFSMKAAAKKRLDELPYMPTCLARAPMYVPIGSDASSALDMHRIYVPFDALDFPHSFNLSVHQDSVRGWRPELHNSTVTNIATGRIPLRPSLGPEGLPPLPEIYSDAIRRQIFTHRSYYARPTHIFEDAPYDPSPDNEMLEHLGDTVLSLVVINLMREVFPYLRVGPSTKIRALVVGNPTLASMCASFPDSRRHGILPTAIPNPHVHQFCEISSPGAPADAPGPGYHPEGLSAYPRHAYFPDLFEAFVGGLYLDRGLEIVQSWLFPLLQPYIVEAYRIVRVQHGLPADPPRIEINTPSYDSSSSGGSSAPTSPTWSTPAPSRVTASIGHLSLFNQHMQQQGKAIEWVWVDSAGQGTLTTPIWVVRAIVEGECIGRGRGSTKKAAKNEAAKVGLQSMGVCVSSSEIPGSLPTSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCP2</accession>
    <name>A0A401GCP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0210950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610806.1">
        <property type="nucleotide sequence ID" value="XM_027755005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCP2"/>
    <dbReference type="STRING" id="139825.A0A401GCP2"/>
    <dbReference type="GeneID" id="38776810"/>
    <dbReference type="InParanoid" id="A0A401GCP2"/>
    <dbReference type="OrthoDB" id="110914at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018810966" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="343" mass="36678" checksum="6B33565A3505EDA4" modified="2019-05-08" version="1">MILLTLLLHVLPTAFTLSYRAADFSSLLLVESQGVNYTDAGVTLPFETILATHGCNTARIRVWTAAQYDLEYSLAMAKRVKAAGMTLIVDLHYSDIWADPGHQAIPSGWPANLTGLMAEMYNYTAGIVTSFAAQGTPIDILQVGNEINSGLLWPVGEVSLNGLEPVSLLLKSAVQGAKSVVGSQRILIHLANGWDWDDLSYWYSGVFGTPGGLTLSDVDVMGVSFYPFYGTNATLAALSSSLHNLTSAYGKEVVVAETDWPVVCPNVTLSEPGVPVSVLGQEIWSNDIEDVLLSLPNGLGQGIFYWEPGWIGNAALGSGCADNLLVTASGATRQSINIFGWDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCZ6</accession>
    <name>A0A401GCZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0212340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610945.1">
        <property type="nucleotide sequence ID" value="XM_027755144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCZ6"/>
    <dbReference type="GeneID" id="38776949"/>
    <dbReference type="InParanoid" id="A0A401GCZ6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7165" checksum="A010B92377E27ECB" modified="2019-05-08" version="1">MVEAAEDADLQDTSARWAGAPSWCPWATVAALRRTIRSTADSRCSSRLRSASLSSGASPAGAEQPTSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDK0</accession>
    <name>A0A401GDK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0214710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611169.1">
        <property type="nucleotide sequence ID" value="XM_027755368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDK0"/>
    <dbReference type="GeneID" id="38777173"/>
    <dbReference type="InParanoid" id="A0A401GDK0"/>
    <dbReference type="OrthoDB" id="3063780at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="496" mass="55769" checksum="F39B29AAAABA07A9" modified="2019-05-08" version="1">MMDSQMSSDQTTLSEKLQLLQELSYSDLDMPYKGSGVHSNREIRESRTTSDIHILDVIAICLTTGEPGDVVAVAFDREQRLSLVLAKNGSPTLEDELATQNLISAITDPEVAYAMDIFHTLLSRCRVNMEKRMSNLHQSISLFVVDLDSALQEYVPKSIEDEFPDSTRFRRENYGDIAPPFRTMLQDLVRMIGDSSAVPLVPDDVELSRSRFGDLYVVAIALLRSRFLGHLCADKNLLNAAQRGRGEKLKRRLAKVCQYYGGVTKLIRNAKRYFPDGHIPYRWINNRFIGSGEGQFELCNDYLDAVQRAFGYPLSPQTVNALEQRFPDMLSNWARRRTVNTCVHAELRIILHLSSASSHPRRTVGPPEQEAIGCSKRSCFCCALWIDAYNDEFKTEWLTSGSHGKPYATWALPGPSYAHARIRSGKNVVDAAVLDGVSVRLTDTLAWLFPGQKRVSDEHVSTGESSDSEGSVEAVIDEIYSYKEFRLRGIRGGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE82</accession>
    <name>A0A401GE82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611407.1">
        <property type="nucleotide sequence ID" value="XM_027755606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE82"/>
    <dbReference type="GeneID" id="38777411"/>
    <dbReference type="InParanoid" id="A0A401GE82"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="259" mass="29136" checksum="3AFBA939B750FFE7" modified="2019-05-08" version="1">MPTSAIDDLVHNILAEVVSTIMSTPASSTLVNRISSQTQTPFIHASSPSSSIELSHASDKQEFATHLISAICTPVDFTDILVALQNRPQDRQVVVSMQRALEMVEWMQTARQELIAAEERTSRARTRVDQVWFLMRSTVSRTAQEIWREHGDEDIGHILGYTTDGRPASTPRSSPEPIPVRPRPPHSHVPQVNPHYRNPPSHTHRLLCVAVIPVVMDVCMNKDHELAEGRATDVEVIIMSGTIPDDDEDYKYFLWDKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEW6</accession>
    <name>A0A401GEW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GRF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0304000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611594.1">
        <property type="nucleotide sequence ID" value="XM_027755793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEW6"/>
    <dbReference type="STRING" id="139825.A0A401GEW6"/>
    <dbReference type="GeneID" id="38777598"/>
    <dbReference type="InParanoid" id="A0A401GEW6"/>
    <dbReference type="OrthoDB" id="5418639at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680:SF1">
        <property type="entry name" value="OS05G0489500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33680">
        <property type="entry name" value="OS07G0190500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="398" mass="43356" checksum="6B22F8ABB3197C6A" modified="2019-05-08" version="1">MAKSKTNPRDSEGVVRCPGHHEPAQRLVSKTDRTRGRAFYKCAKPVNSEQCDFFYWEDDLPPAQPQAAAPGSSQESPRPSQRQRAIMARTPSAPSSPTKRPRSATPPATPTRQGPSYGSQALLSGSQMTPSSKFTPSQKERRLMDINAGLSARKSMESLRSVPPSPSKRSRIESSEGGHSYSPTEGDVGGQEESVDEDAVWLSHQSQGEDGARPSTPPPYHFRGTHPEIRGPRTPGSSSAHGRSENDMLLTPPQSSQLAYASSSQLSYADAPDSPTKDKGKGKALDGSNLLCDKIQADPEYPFYERAAALQGSTQTGGSVTLDQLSADVINSRIAGLSNIPDYVRKLEGKLAAAQQSVLAKEHRIEELERELKQEKLSIQNQKNTYMEIISTMQARRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF18</accession>
    <name>A0A401GF18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chaperone J-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0304960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611690.1">
        <property type="nucleotide sequence ID" value="XM_027755889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF18"/>
    <dbReference type="STRING" id="139825.A0A401GF18"/>
    <dbReference type="GeneID" id="38777694"/>
    <dbReference type="InParanoid" id="A0A401GF18"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="429" mass="48757" checksum="BDF5D67B1A6F3B43" modified="2019-05-08" version="1">MLSFILSFFGWSYLPDYATQHLLPIVHRHFYQRVLRRIPPPPNTPLWWQHYRYVYAFTVFSYLCYNFRDAAVSMAPNYYETLGVEPVADENTLKSAFRQFARKNHPDRVGPQGESAFIEVRDAFDALKNPVTRFAYDRFGPDALKWTQCSTLREYIRHGLMQSSGFYIVAACALLLWSVIGKPSHVAFWRYLLFAIVFAYELTFILNSSPSRPVDSSLSSSIFSASVSSLCTTLFAFIWPQRVAYQHIRFLHSLFLFLSVALSRVAPVLFPSPQQDYADAKRINGEIDRINLLARLIDRDVSSQIQVDLHSVHGPRTNTPPTDATFAYVPPCTEPAEGVVNRLTSEMENMVIESQLRDGGPLKRAVDAVIAKQRRAQEQKTTNSRTGMPSPTPSPPPPLFLRHDRTSSHERPSSGSSLSGYVRGRSQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFU9</accession>
    <name>A0A401GFU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Carbamoyl phosphate synthase arginine-specific large chain</fullName>
            <ecNumber evidence="13">6.3.4.16</ecNumber>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SCP_0307730</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="13"/>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611963.1">
        <property type="nucleotide sequence ID" value="XM_027756162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFU9"/>
    <dbReference type="FunCoup" id="A0A401GFU9">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFU9"/>
    <dbReference type="GeneID" id="38777967"/>
    <dbReference type="InParanoid" id="A0A401GFU9"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="211"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="749"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="1015"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GBE81050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128646" checksum="2A2EF4F149837451" modified="2019-05-08" version="1">MGLLRLYPGWTSRLLQCSRSPRLTRQFHVSRFRSAPCPSKPVHAIPQAAVGSYTQQDGGHVLNSPSELARRLSAKVLPKIPRPNVRKVLIVGSGGLSIGQAGEFDYSGSQALKALREEGVDAVLINPNIATWQTSHQLASEVYFLPITPDYVAYVLEKERPDGILLTFGGQSALNVGIALDKMGVLERLGVQVLGTPIRTLEVSEDRDLFVHALKEIDIPVAQSTAVSSVNDALNAAEKIGYPVILRSAFTLGGLGSGFANNSDELRDLSAKSLSLSPQVLIERSMKGWKELEYEVVRDAADNTIICCNMENFDPLGTHTGDSIVVAPSQTLPDDEYHMLRSAALKVIRHLGVVGECNIQYALNPTSREYCVIEVNARLSRSSALASKATGYPLAYTAAKIALGYTLPELPNAVTKTTTACFEPSLDYIVTKIPKWDLAKFSAQVNREVGSAMKSVGEVMAIGRTFEESLQKAIRQVDPRWKGFEAYVQPEDLDYALSHPTDMRLFAIAYAMFNKQYTVDKLHDLTKIDKWFLYKIDNIVQTVYAIKEVGSVEKIDEELMRRAKCMGFSDAHIADLVSSTENTVRAHRKAFGITPFVKRIDTLAAEYPAHTNYLYTTYNASEHDVEFDEHGTMVLGSGVYRIGSSVEFDWCAVTCARKLREMGQRTIMVNYNPETVSTDFDEADRMYFEELGYERVMDIYELEQAHGVIVSVGGQLPQNIALRLKDNGVSVLGTDPEKIDNAEDRHKFSSILDSIGVDQPEWTEVTSVEDAKTFAQKVGYPVLIRPSYVLSGAAMNVVYEESALEYNLSAAASVSPLHPVVVSKFIDNAQEIDVDAVAYQGKLLLHAISEHVENAGVHSGDATLVLPPFSLTDEDMLRLKHIAEKVAAAFEISGPFNMQVIRKAADAPEQEALLKVIECNLRASRSFPFVSKVLGHNFIDVATAAIVGQGVPEPVDAMAEKRDYTAIKVSQFSWTRLGGADPFLGVEMASTGEVAAFGQDIHEAYWAALLSTTGFKVPRAHTGVLLGGDTTKPEMRTVAKGLIDLGFKLYCSSPVVEEFLNSIPYVSAKRIIFPTKDKRKLREVFDEYDIECVINLAKARGTGATDEDYVARRNAVDFGLPLLNNARCAQLFVESLAKKIPQGGLRSYTEGKIPSEVRSWREFVGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGE6</accession>
    <name>A0A401GGE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hsk1-interacting molecule 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0309660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612152.1">
        <property type="nucleotide sequence ID" value="XM_027756351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGE6"/>
    <dbReference type="FunCoup" id="A0A401GGE6">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGE6"/>
    <dbReference type="GeneID" id="38778156"/>
    <dbReference type="InParanoid" id="A0A401GGE6"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="490"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="591" mass="67275" checksum="EA17B7E3A0CD2B40" modified="2019-05-08" version="1">MATILRNPLAVRPHPHQSASISPYQTTLRRATPATAIKRPRSPEPGGAAHLQSAKRHKAAVQQHTAAREDAKKEKERKRIEREEEFKIKYSRAFPTFVFYFDMDTFATDVAAMRHVLERRVTQMGARVDDFFSRDITHLITFQPEESNKENVTQTINPTSLLGSPIRLKGRAKIDVSGTALGNIVQKALAFNIKVWNPAKLENVLERCQGPAGAGTTSKGDLKGMLLSERLHGTTERDPTQRRHDYAYFSKNSCFVLVEDMRQDLATIAASEYPCTKTRDGTIKGPWPILYCHPKARGPFIPFDEREDRRRQKADRAEREREHERARRKARLQRQERLRRTQARLQEQQKQQHDLRRCASMNNLQRRSAYPDPSMEGFIDLDADDTTESANASGYLASGAYIAASGNSVGITSTTGTTSAAAGPLRIRELPSRLKGRLQQQVVTSRRVTMSILSGGKENQMGPPPTLPDRPHVLRKSRSTNTLRLPKREEGTKPGYCESCRVKFTDFIEHINTRRHRKFALDDSNFVQLDYVLERVKRRTIEEVAEENRLWSSRLNSREGDDGDEDAEMMLPMPDAVMGEDVRWDEWVDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGH9</accession>
    <name>A0A401GGH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0310050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612191.1">
        <property type="nucleotide sequence ID" value="XM_027756390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGH9"/>
    <dbReference type="FunCoup" id="A0A401GGH9">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGH9"/>
    <dbReference type="GeneID" id="38778195"/>
    <dbReference type="InParanoid" id="A0A401GGH9"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="107"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE81278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="376" mass="41252" checksum="32BB457A02AC3864" modified="2019-05-08" version="1">MKAVEQGPSSNWLALQKKLPVSGKKNDGVSAASARKRRKIGHTSNADGETVEEIRYAAAGTSFARGRTQEQLLELPDSVVNGESLSALRKMISGELEYSSAHQQPGKYLALDCEMVGVGIEGKESSLARVSLVNYHGAVQLDVFVRQREHVVDYRTEFSGVRASDMVNAKLFPEVQKQVAELLKDRILIGHAVHNDLKALLLPHPRSLTRDTQVYAAKYKVTRSRRIALRHLVQQELGVIIQGGEHSSVTDARATMAVFRLHRKEWEKGQRPDALPSTTTRSTAKRKRAPTEGEDSGSTASPTPSKRKVDSPGGGRKGVSSGLSTIVKKRDKGREVMTKTRNTNIKRDVGSNTKGKWWKELGVTSSKGSISLKVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGN8</accession>
    <name>A0A401GGN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612263.1">
        <property type="nucleotide sequence ID" value="XM_027756462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGN8"/>
    <dbReference type="GeneID" id="38778267"/>
    <dbReference type="InParanoid" id="A0A401GGN8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7529" checksum="54939F579AEB5073" modified="2019-05-08" version="1">MVDKIAHALRNMNDLACAREFEALKPSLGSRAVRPVVLMRSPLSSTGMDRHLAQFPGKGAVDPEQAKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGS6</accession>
    <name>A0A401GGS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CLF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor clf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0311250</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612309.1">
        <property type="nucleotide sequence ID" value="XM_027756508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGS6"/>
    <dbReference type="FunCoup" id="A0A401GGS6">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGS6"/>
    <dbReference type="GeneID" id="38778313"/>
    <dbReference type="InParanoid" id="A0A401GGS6"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000327">
        <property type="entry name" value="Pre-mRNA-splicing factor CLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000639">
        <property type="entry name" value="Pre-mRNA-splicing factor CLF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="59"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="221"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="383"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="693"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE81396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="746" mass="87627" checksum="6FD2CED96021F9D1" modified="2019-05-08" version="1">MQDGRAPRIKNRAPAAVQVTAEQLLRDAQERQESQFRAPKQRVEDFEELHEYRGRKREEYEKRIRQTRGSIKEWLQYANWEASQSEYARSRSVFERALDVDPRSVQLWLSYTEMELKGRNVQHSRNLYDRAVTLLPRIDQLWYKYVYLEELLQNVPGARQVFERWMQWEPDDKAWQAYIKMETRYHELDRASTIYERWIAVRPEPRNWVKWAKFEEERANLSKAREVFQTALEFFGDSEEEVEKAQAVFGAFAKMETRLKEYERARVIYKYALARIPRSKSAALYAAYTKFEKQHGSRSTLEATVLGKRRIQYEDEISQDGHSYDAWFDYIRLEENALQEARDEGSPDEEIAGAIARVREVHERAVAHIPPGGQKRHWRRYIFLWLNYALFEEIETKDYDRARQVLETAIRVVPHKQFTFAKLWIMFAKFEVRRLNLDAARKIMGTAIGMCPKEALFKGYIQLELDLREFDRVRTLYEKYIEFDPSNSSAWVKYAELEAQLEDFERTRAIFELGVSQMPLAMPEVLWKAYIDFETEEGNREKARALFERLIAQSGHWKVWVTYAEFEAAAIPVARALREEKEDEDEEEELVEGDIDLARQVFERGYKDLRRQGLKSERAALLEVWKTFEEKNGTPEDVEKVVNMLPVVSRRRMADAESGGAEVVDWDMVFPDDERESHPTSFQFLKVAHAWKKAQATKSKEHANEHPAPSTGGDAGQEQPPVAQAANSQDKDEDMTSDVASSHDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGY1</accession>
    <name>A0A401GGY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0311580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612342.1">
        <property type="nucleotide sequence ID" value="XM_027756541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGY1"/>
    <dbReference type="GeneID" id="38778346"/>
    <dbReference type="InParanoid" id="A0A401GGY1"/>
    <dbReference type="OrthoDB" id="2955493at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019033416" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="145" mass="15416" checksum="5E8098235AFD57C1" modified="2019-05-08" version="1">MRFSTLSTLLISALAFGFAQAAPSPVPASLERRGVATVEEATSKAPNADIVYPGYDAILVFSGEGCSGTEDIIDISGLDLNVCYEPAIEYLSIMAYSPNGGTWDLTIFAALANCADPTQLANLNVCYNVLYNGANAYFSTIYFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHU2</accession>
    <name>A0A401GHU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0400640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612606.1">
        <property type="nucleotide sequence ID" value="XM_027756805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHU2"/>
    <dbReference type="FunCoup" id="A0A401GHU2">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHU2"/>
    <dbReference type="GeneID" id="38778610"/>
    <dbReference type="InParanoid" id="A0A401GHU2"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="114"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="316" mass="37166" checksum="58BEBF266FD0C175" modified="2019-05-08" version="1">MARRLYLGRLPPDSRAEDVSKFFDGYGRIVDCRVMTGFGFVEFESSRDAEDAVHHFNGKPFMGAKYACLILFIVVLEVADFSRSIVVEFAKESRPRRDPYESERAPRAKRPPGFRLTVSGISRDTSWQDLKDFGREAGSVSYADIDRDNPGDGILEYLSREDAERAVKELDGKDLRGQAVRVSLDPERSGPDNYRRDTRRDDRRDDRYGRDDRYGRDDRATYRRERSRSPPRRADYDDRRPPRSPPPKKDVDDRRPAGYDDRRGGYYDDRRGPDPYYDRRRDDVDKRRDDRRRDEKDDRYDDRPPRHSNGDSGWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIC4</accession>
    <name>A0A401GIC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0402820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612821.1">
        <property type="nucleotide sequence ID" value="XM_027757020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIC4"/>
    <dbReference type="GeneID" id="38778825"/>
    <dbReference type="InParanoid" id="A0A401GIC4"/>
    <dbReference type="OrthoDB" id="3236755at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="130" mass="14726" checksum="015EA1A714E4755A" modified="2019-05-08" version="1">MMVSEAQVRQYYRSAKRVRPNSNPRPNVQFYNIDSLLLDDTKKQDGDMDDGESKPWLDKPRESALEKCRANVFVLEEDIDLSQSDLCDMLVSDPPTPNVPAHENRQKVEGGSDSLPGGNGSSDADWEFHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIM2</accession>
    <name>A0A401GIM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0403980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612935.1">
        <property type="nucleotide sequence ID" value="XM_027757134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIM2"/>
    <dbReference type="STRING" id="139825.A0A401GIM2"/>
    <dbReference type="GeneID" id="38778939"/>
    <dbReference type="InParanoid" id="A0A401GIM2"/>
    <dbReference type="OrthoDB" id="2666783at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="533" mass="58541" checksum="377690EF99B98831" modified="2019-05-08" version="1">MEWWVFFRRVRKVVFAVAAISSLVWTILLSVYLAREWDHFFALQRGIIFGMIGVNGLSSVMLYLMIVVVFRFWADLSRMIFLLAIHLGSTVPYTHSTSSFSCAIFSSRSFCDEANMFILANAWIIIGLFLCYTAFLLAVYRVPRPVPNTGLDLLSTSKRMSRTSDKSPSSASATELLQDDVEQNARPKSPDSIYSQVSVISPRASALSTVPRAMDPPSTSRLPRPVGSYGAMGRPRPMPDTHVFPPRVSSLSSTGTLSPAPSYMSQYSYRPPSRLFRQESVILNPVQTRRRASLRPLLLNTFVEPSRHGTPDTALTSSTYRNSAESEGESPYTKWLSFSSSSTRSKHTRCLSEPEPSPLPTYYSVPFQLQPGISPIARTGTISLYPHSAPPSIYYDGLYSAPAGSAAILLDVPLRSQTATPGSHSIHSLTPSLHYAEQCVVAKPPCSAHVRAASDPLPSPYGSNLSSLDHESMADLLLPNPHEAMVARGIRRYSSLVSQHTLQSSRGATPTTATRTLADPEWRQLVMSAALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ05</accession>
    <name>A0A401GJ05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0404700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613004.1">
        <property type="nucleotide sequence ID" value="XM_027757203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ05"/>
    <dbReference type="STRING" id="139825.A0A401GJ05"/>
    <dbReference type="GeneID" id="38779008"/>
    <dbReference type="InParanoid" id="A0A401GJ05"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="15"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE82091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="318" mass="34889" checksum="60784C8871BE6FA2" modified="2019-05-08" version="1">MLRQDPFENLISFICSSNNNISRITKMVKSLCQHYSPPLLTLAPPATSSGEPTSEEHSATDSYHPFPPPSVLASSEVSAKLRSLGFGYRADFIQKTAKMLVEAHGTTKAVEDSLEPSERWLLTLRRMSTCDAREELLKFMGVGRKVADCILLMSLDKNEVIPVDTHVHQIAVKHYGLRVLAKGKANMTPKLYEEVSTKLAAVWGDYAGWAHSVLFTSDLRSFSSHGLPSPSPTPSVAGSPQKTAGAGSVSDTARPSPTKRKRVKVVQLVNKGSGTIIDHQLNLPTAVGSEMDDDHILSLADRVKRRRRTKMVEVTLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJP8</accession>
    <name>A0A401GJP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pumilio domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0407810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613310.1">
        <property type="nucleotide sequence ID" value="XM_027757509.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJP8"/>
    <dbReference type="GeneID" id="38779314"/>
    <dbReference type="InParanoid" id="A0A401GJP8"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000486">
        <property type="entry name" value="Pumilio domain-containing protein c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000842">
        <property type="entry name" value="Pumilio domain-containing protein c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="452"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="578"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="757"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="818"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="892"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1193"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1232"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1294" mass="137645" checksum="79E7EE3081DD63EC" modified="2019-05-08" version="1">MSLSASDSNGSFSRVASGKTPPPAPSAAFAKRAREIEAEERLGARYRPPALRALASGGSPPNDSPSTITPGDTSTLPPPTTYPAGFRRARAGTLPSNVQLAAQRFAAASSNLGSTPASTESFSDQLQRQTITTPSATPAAAPVRPGLRHSASIASSVASSALTERQSRLRSGSLTLPTGNLSNAFGSSIFSSSWLSRNDGGAGLPVLDDLRSVTSMDSGADDFDVHTLDYLGLDETLRHPPAATITELRNQAQAAIAGNLASHPSRLRAITVSTPYHVRSSASNPLLSTPTAQEEEEFYDEDMYHSQGLDSYDDNESNDFLSSNYVAKGFKHGDHLTLPGLGSRPRAISVGNLDDTSRSLHRRAAAAEAQQASYATDLSLQTALGSGSLSPASILRSDKLTGIRNGGSPTVHFPVGELPRSSSYLAAPSTSQNRAVSPKSESSSTQMQTPTRSLWIGNLDSSVTSEQLIHVFAPYGAIESLRLLPEKECGFVNFVDQADAVRAKEDVLNRLGGDIGMPNGQTVRIGFGKADSAPVAPAKGTTLNSPSATSPGGVLGKSTGNNSGLAGMDAQLQSTPTRALWIGSIPSTTTPATILSVFSPYGPIESARVLTHKNCGFINFERLDDAVRARKALNGRDVLGSDVGAIRIGFAKVPVKNGQESNGAQDDSVGLNVQGIGDLSVGATIHALRNIKGASTIPVDQQVLSGAVENYRSNLLLSMISSGAHSPYDGVGKPAGWTASVTEQQMIMKELSGGSPDADADIQALAEFRPPTMYYTTIPLVSERPHNRRWDASKLRELRKRLDTSTISTEEIDNVAADFLDGEIVDLASDWLGNTVVQKLFEKCSAGPRLAMLERISPHLAMIGIHKNGTWAAQKIIECVQTPDEVAIITQNLRPYVPPLLLDQFGNYVVQCCLRFGAPATDFLFDAMVDRLWEIAQGRFGARSMRACLESTNITLSQQRRIATAIILNSIPLATNPNGALLLTWLLDTSSFPSRYNLLAPRFTPHLSHLCTHKLASLTVLRIVNQKVEPEASSQIVEALFSSPGDHVLTDVLGDQVNGVAVVHKILTSPFVDPALRPTYVDATKRVLIELKVIATQAYRRLIEEVGLPVPNLQPTYSTNVPQPSKTKYTAQSNYTMPGLPAGYPSNDQGLASMMAALQMGGQNAASGPPRLQIDPGYGQVPQNGTGRGRASNPPSAFSPSTDPFNPFRSPDVNTQRNGVPRRNGGMPSAAGGTSSIPFGAQSPSLTQAANLMGMTPPPYASMSPQSVPPHVYQAYMYQMYQQQNTPNMGTFHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJR1</accession>
    <name>A0A401GJR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0407760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613305.1">
        <property type="nucleotide sequence ID" value="XM_027757504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJR1"/>
    <dbReference type="STRING" id="139825.A0A401GJR1"/>
    <dbReference type="GeneID" id="38779309"/>
    <dbReference type="InParanoid" id="A0A401GJR1"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="568" mass="60953" checksum="73BD30891E3A0A26" modified="2019-05-08" version="1">MALSDFIITDDLTVVLGLVAICLFLLHNLYKPQSLVHPILLGRQSDVARVRNPGESATYRNYSTGMMGRFPARPTKDQHCILDLVRPDADAPRTLWSTKITNPELRERVSSFANGLVRYAGLVPQESNVLLLLNDSIEFIISDLALASASLPSFLLTSLRLLSPLLESHPPTAIVTHADMLPSLLEVIYDSHESGHHTIIVVGNFDNSVAASVGHVRLLRWESVEREGAQGDKLILPDLHPQDIFSVSFFEGLSGELEGTQLTHENLTAGVASVRALLPLSSAMSPLDTLISAFPLNTPYGRAVAYTAIYEGTSFATLDSTKLISSGGAAATALADLASANSFPIPSPTILFIKPSHLNSLSSEIIDKAKASSPLLYHLGWRHKLSGILEGFITKRSLWDRLVFDSARVNVMDKGAGTVRGVIVGGEPLEAQTLVLCRIALSVPLVNAYIHPLVTGPVFASHPLDLQTFPSAVSSSSSAADAYTFSYLAPVGPPSVNVEVKLRGVDDSAVEAGADPCGALFAAGPVVGTLLRLQDNQDEYELGWVELGERAKVATNGTFKVVEDKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJT4</accession>
    <name>A0A401GJT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein shq1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0407970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613326.1">
        <property type="nucleotide sequence ID" value="XM_027757525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJT4"/>
    <dbReference type="FunCoup" id="A0A401GJT4">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJT4"/>
    <dbReference type="GeneID" id="38779330"/>
    <dbReference type="InParanoid" id="A0A401GJT4"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00298">
        <property type="entry name" value="ACD_sHsps_p23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="474" mass="53861" checksum="3437D0971094BE81" modified="2019-05-08" version="1">MITPRFSCSQNDSSVIVAIYCPSVRASDVEINVDETLFSVHINPYFLRLNFAHALVDDEQASASYDPSSGYLTVTLTKGVKGQEFKDLDLLAKLLAPRPPEHLPEQPLIEVLSSEDAPVTEDDELSARAQSLTLEHDEFLEAAQNDWQLPQDLPEALPPLQTSATHRYGFLDMHSGYFRHVAHTENEVNELGVDAETCPPDERRRKRLEHEEEKWDEEYYMADFVEDEYIQELIAWRNPHVTATDEFKYTEEENLTMLRLPRKEYLATPSQAHNLYLTLLSLLFSHAYETRTTQHDPTPESAWTIGSLTPAFSALDPPPYSPTPPPLSQSSSFDASELAAVFTASYRRALAFPLHRSFALAEACRADVAALLTKGKRAVIRCLLEMKHILDHHDVYYVYSKIWVDDFCVWTATYASDDVLHQLSRDVARLKMEKSMIGRDLDGLEALTREAAEREPDSDDESEDEIERMLPAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKJ1</accession>
    <name>A0A401GKJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0410730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613601.1">
        <property type="nucleotide sequence ID" value="XM_027757800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKJ1"/>
    <dbReference type="FunCoup" id="A0A401GKJ1">
        <property type="interactions" value="866"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKJ1"/>
    <dbReference type="GeneID" id="38779605"/>
    <dbReference type="InParanoid" id="A0A401GKJ1"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="303" mass="33167" checksum="3F88CD7C6F888F5A" modified="2019-05-08" version="1">MSFALPARQVTFGRSAHVPPQQQQYQPPQPQQTNLALPYAPNSYVAGPSSLALPGPQAVAQPVVAYQPPQQQQASVQQQTRHLQSPASNSQTIAIAGPSTPTATAVPATPAPLTLEQQHITAVEGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVVTGAKSEDDSRLASRKYARIVQKLGFDAKFSEFKIQNIVGSCDVKFPIRLEGLAYSHGQFSSYEPELFPGLIYRMIKPKVVLLIFVSGKIVLTGAKVREEIYTAFNTIYTVLCEFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLE2</accession>
    <name>A0A401GLE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoacetate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0500400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613910.1">
        <property type="nucleotide sequence ID" value="XM_027758109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLE2"/>
    <dbReference type="STRING" id="139825.A0A401GLE2"/>
    <dbReference type="GeneID" id="38779914"/>
    <dbReference type="InParanoid" id="A0A401GLE2"/>
    <dbReference type="OrthoDB" id="9970474at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31917" checksum="EE72D20F0C30E48A" modified="2019-05-08" version="1">MDNNHLPVSDLPAPWLFEGEAWWFFTALFHRPKKGEMSAPGYFDPLHEHSRSLATEEDAYLGNHGMIQLLRYTESPAGPYDELILIPGSFKSPPGLKPAEAPRITRIYVSAMNSVINGRRNWNIPKTLAKFSFAPNSDGEMEVKVFAPTSFENPESSIFSDTPFFAVNIRPRAIPLPEIPLNLKHSPIPFTLVQPPLEASPTAAQDGCIGTDNWVSVDVADYRGRVKPISWKGDLTVVDPDTQKVRTRIADGVGFPDIVPYSIGLHFAQLKVQVPEGIIHKMSEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLJ0</accession>
    <name>A0A401GLJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maintenance of ploidy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0500920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613961.1">
        <property type="nucleotide sequence ID" value="XM_027758160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLJ0"/>
    <dbReference type="FunCoup" id="A0A401GLJ0">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLJ0"/>
    <dbReference type="GeneID" id="38779965"/>
    <dbReference type="InParanoid" id="A0A401GLJ0"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="248" mass="28173" checksum="9DF3BC4F61D0AC68" modified="2019-05-08" version="1">MSFFNSIGRSMTRAPRPPRRSTTPTSSSFPSNENLPGAVVTHTSVPRPLYLSSPFVDAALVKGNFKHIVMLPKYADVMEWVAVNIFDFYQNLNQFYGVLAECCTQQSCPTMAAGPTLSYTWVNQDRKSVQLPAPTYIDYVMTWVQNSLDDETVFPTKSGREFSQNFPSTVKHIYRQLLRVFAHLYHAHYPQILHLRSEPHFNSLFAHFLAFGKEYELLDIKDVKGQSNSPVGVGALLEKWKEMGILES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM50</accession>
    <name>A0A401GM50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0503490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614214.1">
        <property type="nucleotide sequence ID" value="XM_027758413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM50"/>
    <dbReference type="GeneID" id="38780218"/>
    <dbReference type="InParanoid" id="A0A401GM50"/>
    <dbReference type="OrthoDB" id="3265172at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23385" checksum="414096529B882F00" modified="2019-05-08" version="1">MAQTSVLPFQSASGGYSSLPVTGESTPPQSRTMMYAVIAPATPSTALTKPADTAVRLRSAAALNSTEQYWAARALTAEAALSVRAAFHQEVYVLTESHEEKRAHELAELQRIHDERHAKLERLVLILLGCLFAFVSAILYILFRQHTDYRSSRWCLPSHFTIPVLSPFTSVVEHETSVFNTRSITIVLLVLAALAYACFRYWLSHLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMA9</accession>
    <name>A0A401GMA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0503830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614248.1">
        <property type="nucleotide sequence ID" value="XM_027758447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMA9"/>
    <dbReference type="FunCoup" id="A0A401GMA9">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMA9"/>
    <dbReference type="GeneID" id="38780252"/>
    <dbReference type="InParanoid" id="A0A401GMA9"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="599"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="406"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="731"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE83335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="791" mass="85292" checksum="F3E8F65BAF994C52" modified="2019-05-08" version="1">MRIRTLEIRWHDSKPIATCDFQPIQFKKARPAQDKNFAGQSYRLATGGEDNHVRLWMVHPNIMPQSVLEGASTSAATSNTPTLRPPRVEYLATLSRHSAAVNVVRFSPNGELIASAGDDGMIIIWSPTTSPHATSYGSDLSPEEMQYEKEHWKPRTTFRCTTMQVYDLAWSPSGEYIIAGSTDNCARIFTSNEGKCVHEIAEHNHYVQGVAWDPLNEYIATQSSDRSMHIYSISHKSGTLEVHAVGKNTRMSHRHSRTSSSHSRPRTFRRESTASETESIITSASEQLRDEVVSSTSGHQHNSSALLTPTASIPSTPSGSMFPPPSVEYSSSRRSSFSGSTAAGSPLMPSRHARSPSPMPALPAIRMMPNAVTTWTSVKLYGDENYTNFFRRLTFSPDGGLLLTPAGQFEDPSVLPGSSRASSNGHGRADDQPRGRRGNLSPVAPDNQASSSVYIYSRANFARPPIARLPGHKKASIAVKFSPILFELRTHIAPADTPPEPQTVVLEKGVDRTVNVDIAGASSATGLPHNILSPESPLKSFPTIVSSPSIAAPSPRVAIPSGSHGMIMMPSPALSATDSLRPPTPLASKPSTPTVTPIATASIFSLPYRMLYAVATMDTVAIYDTQQAGPVCLLTKLHYDEFTDMSWSPDGQCLIISSRDGYCTIVVFDEILPTHHTQQQTLQLQSIAHQHSLPLTSTSTVATPMSTPSVASIPLPSASPAVTPILPLKRRAETPLTPAPSVGESSQGSRSLIDDPPASGDGSNGPAREEGQEPPKKKRRAALTKVGELGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN01</accession>
    <name>A0A401GN01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0506620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614520.1">
        <property type="nucleotide sequence ID" value="XM_027758719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN01"/>
    <dbReference type="STRING" id="139825.A0A401GN01"/>
    <dbReference type="GeneID" id="38780524"/>
    <dbReference type="InParanoid" id="A0A401GN01"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="32"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="378" mass="42612" checksum="2E19B964F989ED29" modified="2019-05-08" version="1">MSSLPDVPAPFSPLVKLNLPSPEEYRKRKVALISGITGQDGSYLTELLLSKGYEVHGIIRRSSSFNTSRLHHLYEDQHERPNRFKMHYGDLSDSTNLVYIIAQVQPTEVYNLGAQSHVKVSFEMAEYTGNVDGLGTLRLLDAIRTCGLTNYVRFYQASTSELYGKVVETPQSETTPFYPRSPYGVAKLYGYWIVINYREAYGMYACNGILFNHESPRRGRTFVTRKISRAAADISLGKQSCLYLGNLDAQRDWGHARDYVEGMWRMLQQPQADDFVLATGETHPVREFVEKSFAILGMQIQWRGSGTSEEGIDAKSGKVVVKVDPGYFRPAEVDLLLGNPAKAERLLGWKRKVDFNSLVKEMVEADLTAAKSLIEDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GND4</accession>
    <name>A0A401GND4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0508070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614664.1">
        <property type="nucleotide sequence ID" value="XM_027758863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GND4"/>
    <dbReference type="GeneID" id="38780668"/>
    <dbReference type="InParanoid" id="A0A401GND4"/>
    <dbReference type="OrthoDB" id="2612908at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="138" mass="15447" checksum="A5597DEB2828DE1A" modified="2019-05-08" version="1">MEQVTAITLIADIFSNLYAYIDSVVCDVRKHPLLHPKIHLVKGVNKWYVSLYRRDTVIYLTWPECEAQVSGFPGMKHCSFMHLQDVIAFYIDKGDEGVIQPVRPLNMGIGQTPAKPPAMAPSTPSSNHPEGSSQALFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNI5</accession>
    <name>A0A401GNI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0508180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614675.1">
        <property type="nucleotide sequence ID" value="XM_027758874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNI5"/>
    <dbReference type="STRING" id="139825.A0A401GNI5"/>
    <dbReference type="GeneID" id="38780679"/>
    <dbReference type="InParanoid" id="A0A401GNI5"/>
    <dbReference type="OrthoDB" id="3181259at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="508" mass="57636" checksum="481AD22453C60930" modified="2019-05-08" version="1">MDEALSFEDLGVWDDLLDDGVSSAGSDEEFPDPRSIDPRITPPDVVEIDRCLAELEAELARLRMKKAHILASRALIYRLPAEIMSRIFEFGVHDVPELLTVLSLVCRHWRELALATPSLWTYIILKSPWNIPSFVCKLRVFLARAQMCKLLIDIDQNYLDFEELQEVMVELRPHFARCFSFRLSSPSWDFVSSMREYLADLGPSLEMLHLRIHGSNLLESMPYRTLLAPECSRLKSIVLEHIPLACIYQCHFSALRRLYLMRDLQYRDRRGHNGRFGIFFKDLVTTLRATPTIEEVRFQSVAFLVEGNEEVFQSDPAVTIIPSLRVLSFYLVDSPNIALFLESTSLPALTRLSVNMEPSSDENMHWLSCMSSALRSRSPSLRQLDLRACNIDGTALVSFVRALHQLPQLTALSLSSPRLGPLSMQFFELLAAGPATTGAWILPQLRALCVQQCGEITGHELLRVVRARRDTAISDANGICFLKIAHCEGLDEEVLEQLRSVVHTVRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNK8</accession>
    <name>A0A401GNK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0590 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0508600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614716.1">
        <property type="nucleotide sequence ID" value="XM_027758915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNK8"/>
    <dbReference type="GeneID" id="38780720"/>
    <dbReference type="InParanoid" id="A0A401GNK8"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="298" mass="33727" checksum="596C4AF6DD9D6058" modified="2019-05-08" version="1">MPRLRVLAGPSLEELYPVCANSHTPVHISSELFEGQVAVFIKGFADHCGKVNESSYFEAEERKGITWSIQMQGRFLQSYSADDILFGNTFDRPLKLPWGFSAAVKFMQFRDPTLDQDLASKTKPWAFSPLIATMPYLRHQRVEREGQPPPFPPEHPTGEDTSALCTADGRSSAARPMESKNNEKRRTHFRNRAHRQGVIFGPDDLITVDFCHRHLYFSPKGIDLRIPGGISIDIMKYWDGQPVRFVCCERVRDGQGANGKPWGRVFWCVVIERVEEDGSLAEHSEGLTDDADDSKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNM5</accession>
    <name>A0A401GNM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0508590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614715.1">
        <property type="nucleotide sequence ID" value="XM_027758914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNM5"/>
    <dbReference type="GeneID" id="38780719"/>
    <dbReference type="InParanoid" id="A0A401GNM5"/>
    <dbReference type="OrthoDB" id="2691851at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="304" mass="33815" checksum="D7C2D10BF5147474" modified="2019-05-08" version="1">MESWTRRLSIRPLAEQGDDISKKVDHINPESWKGDVSIRNVVLQTCWSLGQGIAESELRAAHIAVPFEAYESSNHDIDMLRPFGDGKVVYIARLRMDEADEEPSIIADSSKSTGTAELHASMAAEDLALEPDVEDLLGPEDVEKEKGQKVEAWLTVSDDPAAKKQHKSTILHWLSNPHISPGLTDHLSRICSFTCYSNFAVVMDMETEFGTPLLTIDDPALTLLQHNPTESVFLAVVRVCDILHDGISKYALPAARVNEPNICIKFDILSLSSITPTEDNHHVDWQWNIKYEQSSSSIAQEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNN1</accession>
    <name>A0A401GNN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0508940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614750.1">
        <property type="nucleotide sequence ID" value="XM_027758949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNN1"/>
    <dbReference type="STRING" id="139825.A0A401GNN1"/>
    <dbReference type="GeneID" id="38780754"/>
    <dbReference type="InParanoid" id="A0A401GNN1"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="75"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="466" mass="50045" checksum="0B79B3BD704F1ADD" modified="2019-05-08" version="1">MDVNARTISVRSRSPYPSAPKLSKPMPNEDSMSVEMAEIGEVKSAKEEDAEGSNTGSIEPTLPPGRINHYKANIQFAAMCLCLFLAGWNDGTTGPLLPRIQKVYNVGFALVSLIFVFNCVGFVVAAAANVALTDKFGFGIVMVIGSVAQVIGYALEAPAPPFPVFVMGYAVNGFGLALQDAGANGYVASLAHNSATRMGILHAVYGVGALSSPLVSTQFSQLPRWSLHYLVSLGIALANTVFLIAVIRFRTQDECLADIGQAPADHSALSNSEDSKYKQIFRLRPLHLLAFFILVYVGVEVTIGGWIVTFIINVREGGPSSGYISSGFFGGLTLGRVALLWLNKLIGERRVIFLYMLLAIALELVVWLVPSLIGGAVAVSFVGMFLGPIYPIVMNHSGRILPPWLLTGCIGWIAGFGQAGSAFFPLLAGLLASREGIKSLQPLLVSMMCFMFCLWALVPSTPRRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP39</accession>
    <name>A0A401GP39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0510460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614900.1">
        <property type="nucleotide sequence ID" value="XM_027759099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP39"/>
    <dbReference type="STRING" id="139825.A0A401GP39"/>
    <dbReference type="GeneID" id="38780904"/>
    <dbReference type="InParanoid" id="A0A401GP39"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="676"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="86459" checksum="BC0DD66D2B5FEFB2" modified="2019-05-08" version="1">MASWVLGQAPWTSLARVRLRFEAFSWPAKQYAWSKNYFSSPLLSQETPAVLELKKQPYPSSPLDSSVFEDMNADYGYEAVAPPTPARRPCNLLVQLVKDQQYADVEQVYAELLEMGVEIRPSSVYYDMALRALEDPDKSPHARMMAFTKWWSLVPPIMHRYRVNVTKVQEIILEQNPFPDPLLIAWFTVISASKGYAYLFGVRAVTLVVRYADPSFSSSFLYTLHQTTLQWLQSLAPRKRERYEPLYEQLFQEWYAFAVRQHCMTGRVDAAVALLRDARSRNVNIDNFTYDFLKGKLRRRRDSINLLLVEQFQRTDVPSGLNPTVSRPPLDLLEEPSLYELDRTVSPTPFDSVKDSSATWALRYWSFSGEKSLVSALRDLRHSMTNSRYPNPVTFAEFMDAYRASGRSVALGILRKQSYSNSFATASWWALSEMMYHYRRQEYALVLLAYAHHFHLVGIPAWLSQHLSTLEKLAQDSRYGRRVIPLYPVPQKHWPMSQHTSLVWRAVVELTAETSGALESLYQELLSQVAASQGAVTTGSLMKPEPLHSLPRVQDWSIPSADEYPAAIPPPTSFDDAHFNVFIRAFINKEGAGPARAIQVIDDMYRFGFKVSVHSLTPLVSAFAREGEQDRLKMLLSRMEESLPSETPAEDSVAEGEGDVAGAAGVAPENALPAPNVVTYTAIIWAFIRTYQYQEATEFVEQLKEKGRYVPGTNRRTDLALAVLKERIRMGGGFEQGQYTLSSPSGSTDYQPSRNPPLQRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPA3</accession>
    <name>A0A401GPA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0600490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614984.1">
        <property type="nucleotide sequence ID" value="XM_027759183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPA3"/>
    <dbReference type="STRING" id="139825.A0A401GPA3"/>
    <dbReference type="GeneID" id="38780988"/>
    <dbReference type="InParanoid" id="A0A401GPA3"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="421"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="684"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE84071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115755" checksum="7DE2FB8B6A12297E" modified="2019-05-08" version="1">MSSTTESRDSLSSLFRIEQLRDDNWLPWKRRTMAILRERGVLKYVNETSEKLKPANATTPTAGETAVITKWVEGDQKAQTVIELLLSDSQMIHIADATTAAEMWNQLKLVKEASGQLGIMAYRRKFYRTVATEGSNIAAHITELRRTQEQLHMMGSKVSDDEFRAILITSLPESWDQFTSAYLGATSQKDKLPTSHELIAILLEEYRRQREKGGADESVLAARGRWTQPKNTAQGGTDRKSDAECWNCHKRGHTQHECWSKGGGKAGQGLRSKKGGHAQVHTNQAQSTNDVLQDVAFRTDEAIADSGMTSHVTNLRDAITDFMPLEASSITGIGDQSIRALGRGTVKVNSRIGGKTFTFCLKDVLYAPKATNNLVSLTRLDEAGGHFDGGDGGITLRESGGHAIAEGRKIGRLYLLYMRAKIATPMNERANVAHEDNDSWESWHRRYGHLGITGLEWLYKEKMVEGLTIDENSMPLTQCEACVQAKQARRAYPKEAEDRSQMPGELTHSDVWGPARVVSIAGSHYYISFTDNCMRRCQVLFMKHKTLYSPSQNGVAEQFNRTLLELARAMLITKNLPSFLWAEAVAYAAYLRNRAPMKALHGRTPEEAWTGNKPNVAHLREFGSDVWILTEGQNLSKLEPKSKKHTFVGFADGLKAVRYYDAGARSIRVSRNFVFADAPKPVSNVPVHQFNDGDRLPLEGESGGAVKQQPPTSASKPASVPVKADQSNKKHDGNHITEEDLPPEMQENMRERPTFLPAPPKIPLHCTTRAMQDHDYRKMDNPRAQPAKSREPPGVPKENALGESAKVAVTPEEFEEIAQALYATALASGDRTASAGDEPRSLTEAQASPEWSEWEKAVKAEYDQLQGMGTWELQDLPKDRNAVGCKWVFQRKTNKEGQVVKYKARLVAQGYSQIPGMDFLETFAPVQSGCEWNRKLHRELTELGYKRLEADPCVYLRERKEGEVQIITVWVDDLLLFTNSPKLMEELKRDLQDLFEVTDLGEPQKIVGIEIERDREVGTLQILQQHYIESILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPB5</accession>
    <name>A0A401GPB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614976.1">
        <property type="nucleotide sequence ID" value="XM_027759175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPB5"/>
    <dbReference type="GeneID" id="38780980"/>
    <dbReference type="InParanoid" id="A0A401GPB5"/>
    <dbReference type="OrthoDB" id="3232670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="507" mass="55422" checksum="037B4C18A368A47D" modified="2019-05-08" version="1">MAMLNRTADLIGRNVTPLSPALLKLEPEQRLRLLRSTQKVGKVLGTTPTLDVISPSASAFSPVTPTPLGSLDASAVRRKPSFILPRSPAAFIHSVTSRASVQEEMVKSPVVRYRLADRSAQPVMGSRPSHNILRRAHIPAALNLPQPRRNEASPLSPFRYNVIGGPPTSRFSPLPAVSPFSPFSPITEQKIEQRKLEKLEKLDKLARCKDDIFPPEFIYPSLGQVSEKVEKISSYLDLYRMGAKDDSHLPRTRYEDQEYISVRAEVGDPDNTTRSRPVSRGLSMSRRRSRSVGDFHSFAALGSSQAEAGSGSRFSIQMNSLAVQSPSSAVTRASYFSPSVYSDTASFGVDSAADVAALAALNSPRKRACSIMSAKQSILGADAKLMAEFRTRFGTRPLDFHFPPFPAPTCPLPSPPVSPTLEQVKSPKVPYWVKSSFRPHTSGAYALGFPDVGPYAQVKSASTASRKNGHLAPPATPRTRRVERRQGWGGHWNQGTMGGVIDQLRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPH2</accession>
    <name>A0A401GPH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615005.1">
        <property type="nucleotide sequence ID" value="XM_027759204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPH2"/>
    <dbReference type="GeneID" id="38781009"/>
    <dbReference type="InParanoid" id="A0A401GPH2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="55" mass="5835" checksum="5D22850C396EE20E" modified="2019-05-08" version="1">MEVSTVQATPSDYDEPLTNVPSSTFVHFPATLGYEVTASVSSPVPGRISQVDHAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQB5</accession>
    <name>A0A401GQB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="19">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SCP_0603920</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17 19">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 24">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="19"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615326.1">
        <property type="nucleotide sequence ID" value="XM_027759525.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GQB5">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQB5"/>
    <dbReference type="GeneID" id="38781330"/>
    <dbReference type="InParanoid" id="A0A401GQB5"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 19" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 19" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 19" id="KW-0408">Iron</keyword>
    <keyword evidence="13 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 19" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="21">
        <location>
            <begin position="1524"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GBE84413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2232" mass="254320" checksum="49D3B2FBD5AD218E" modified="2019-05-08" version="1">MARGSYSGSFRSRGRGNSRNNYRGNSSFRGGRGRGRGRGRGGAPTDPQPRRDDDGTQLAERFEQVQLNDEIDEKLGFERIEEGGRREGWLVNMHPTLVKDADWPSGKAAVDFYFIQDDGGMFKCTYQYEPYFYIACKSGMETIIEEWLMKKYEANIYRITRERKEDLSLPNHLLGHRRLYLQLHFRNVSDLLTVRRDIMPLALANSAKLDAVDAYAEVVNSTAGVGISIDMDVEWGADVNMDARDSRNAGGREKDPREGVIDIREFDVPYYLRVAIDNDLRVGLWYAVTFTAGQPAFTQIVERVKRADPVVMAYDIETTKAPLKFPDQAIDQVMMISYMVDGQGFLITNRDIVSEDIEDFEYTPKEGYEGPFTVFNEADEAATIQRFFSHIQDVKPTVIASFNGDFFDFPFLCARAKVHGIDMFLETGFSKDSEDEFKSRGCVHMDCFRWVKRDSYLPQGSQGLKAVTTAKLGYNPLELDPELMTPYAMEQPQTLAQYSVSDAVATYYLYMKYVHPFIFSLCNIIPLCPDEVLRKGSGTLCETLLMVEAYRGGIIMPNRHEEAHGNMYDGHLLASETYVGGHVEALDAGVFRSDIPTNFKIEPSAVQKLIDELDAALTFCIVEESKTPLESVTNYDEVKSQVQAGLEEMRDNPLRMDKPLIYHLDVAAMYPNIMLSNRLQPDSVVDEAVCAVCDYNRPGKSCDRRMTWAWRGEFFPARRDEFNMIKHALNQETFPPKRAGGSQRKFGDLSDAEQTALLHKRLGDYSRKVYKKIKDTKVENREAIICQRENPFYIDTVRRFRDRRYEYKGLHKTWKKNLDAVLSEHRSIAEVDEAKKMIVLYDSLQLAHKCILNSFYGYVMRKGARWHSMEMAGITCLTGATIIQMARQLVEQIGRPLELDTDGIWCMLPGIFPENFKFKLANGKAISFSYPCTMLNHLVHAQFTNHQYHDLNTETGEYAVHSENSIFFELDGPYKAMILPSSKEEDKLLKKRYAVFNDDGSLAELKGFEVKRRGELQLIKIFQSQIFEKFLLGTTTEECYAAVAQVADRWLDVLFSKAETLGDDELVDLIAENRSMSRTLAEYGGQKSTSISTAKRLAEFLGDQMVKDKGLACKFIISARPMGAPVTERAVPVAIFSAEDSVKRSYLRKWLKDNSLTNFDIRSILDWGYYIERLGSVIQKLITIPAAMQKVANPVPRIRHPDWLHRRVVALDDKFHQQKVTDFFKTGPREQSNQDIEDFGSEREPSKGIRPRIAVVNRKARGREDNFEEAVPEKMPESVTHYSDYLAVRRRQWTRRYRPEGASNIELPLFKGVKTKASGRWDIVQIRPNRIRGRFTLWISADSGLVPIPLRIPRQFYLHLRTPPQADRFKTDVYSAEKVVRSLPRELPCVNLYKLTVREDIYQEGREHFIDLTNDPNVDGVFELQLPLVMRALLKLGKTCASEVPGLTLNRAENSGIDLEQLSRAGPSLSKRKYLDEGRAGKYILLYHACSGNAAVHVFALFIPGNAVRLHIVDPAQRRQSIPRLSELYADTLGKRHQNYGPSISYAYPSTCEFLSTYHGTDSTALKAISRELGLVDSQSYTVVISSSREQVYFDSQVPKLSKFPVVSMSKAKGPHTLDAFPWQTNVAQKLVNRYLTLGTWLDRTIALADYYDVPIGHIDGDQPLLLADVDFARRLTDHDMVLWWSPGDRPDWGGIEDDRRPSEDLPKTEFMSPGCYSNVCLEVTVRNLAVNSVLHSVLVNELEGSGGATAFDSSHTLVEYAGGDSQRDLTLGDANVSPQTFSVLKNMVKTWLLDKIQGNFESPATIAIDHFWRWISSNASCMYDPSIHRFVHGLMRKTFIQMLAEFKRLGSHVVYADLSRIVLVTSKPPGTAHAYATYITTAVTSHELFQHVFLHTERFYDFLLFMDQANLAGVVCEDPLAIEPPQELSIEMRWNIETFLPPAIQRDFRNVVRFFLVELFRTNQKTKEANRVPLRVLANGAPDATQHNASKTQELEASRDFIARRLTRKLLRTVGSIQERHRDAQMDEDALAEWEFPLLPGSHLHLTNPLLEFVKFACAVFGLAKEYQIEVGLLKRNLLEVVGVREFAGEAAFHNPCEPLRLANVPCRHCDGLRDFDFCRDPELLPRTLEVNARWLCVVCGGEYDRTMIEFALMDMVFDLERRFAQQDLRCGKCKKIQSDNVSRHCACSGSYQLSMSKADVRRKLRTIVNVSLAHNLPRLRECAQTMLTYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQP4</accession>
    <name>A0A401GQP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0604590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615393.1">
        <property type="nucleotide sequence ID" value="XM_027759592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQP4"/>
    <dbReference type="GeneID" id="38781397"/>
    <dbReference type="InParanoid" id="A0A401GQP4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="227" mass="26066" checksum="1F9CCB283E1AC52B" modified="2019-05-08" version="1">MSQLTLSVDEMMDMDNWKQFQLRGSRDDRGSIVYRGLYEDVNEDGQLKGEFLNDDSDRGETFLVNRDHTSSPPLSNDESKKSDKLDNTKEEHKETIHQPLSYAPVSDVKEDIKEDVEEDVEEEGKAEAKDEDEDEASVPALPLHVFRATNLSESYTGRKDVQLLLKWMSLDAEAVDSYVILQCLSLLLFMNMRTAYSPLIQLYLLLLVLLSINVTRSSRWHRSLWGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQU7</accession>
    <name>A0A401GQU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0605180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615452.1">
        <property type="nucleotide sequence ID" value="XM_027759651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQU7"/>
    <dbReference type="STRING" id="139825.A0A401GQU7"/>
    <dbReference type="GeneID" id="38781456"/>
    <dbReference type="InParanoid" id="A0A401GQU7"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="10"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="943"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="969" mass="107589" checksum="0784D6FA56C3D722" modified="2019-05-08" version="1">MPSDTHSDGLGQNDFTANALDVLPKSTDVAVKVHSSEVKPVHMMLVLLCGKAPDLDNINMLSVPEPPPLLWAVVSELDGNPLQLAQDVKKFIVSAPRNTPLLAPPTPPPGAKEPSRIGRLFRGDRSRGRHSPSPSVTNLQAPAPPPTTVASDALVDVITRARNHKKNLGDDFVSPYHLLLGLSDDSDVLRLLETQHITQSEFQKELRNRRTTKVTEREDDQFPYLAKYSTDMTALARDGKLNEIVGRDEEIRRVIQILCRRTKNSAVLIGEPGVGKTAVAEGLAYRTAFGQVPQNLKGTIYSLDLGAVFAGAGKGEYEQRVKGIIEDVTRSQESQTPAILFIDELHLITVGKNPGGQSSGMDAANLLKPALARGQFRCIGATTLAEYREHIEKDGALERRFAPVIVSEPTTEEAVTILRGIRERYEQHHRVWIMDQAIVTAVNLAHRFLTARRLPDSAVDLMDEACASARIAQDMKPEAIDTLQQDMLHVAAHIKALERDNHPDDDVALANALETKKKLDLKMGRLLQQQEAVRAWWKKISIQRSAIQDKKREVLFARSEQRQDTSKILKLESTLQKLRDGLVRLEHQGPNVVDDTPDLVGSSRHIISRTSPDIITPESIAAIVEKATKIPVSRLLATDKSRLLNLESALSQQVVGQPEAVKAVTHAIQVSRTGLGNTNRPIASLLFTGPSGTGKTLLSKVLAQELFGQSSSMVRIDGSEYSQSHSTSRLIGSPPGYVGYDQGGQLTEFVRRTPYCIVLLDEIEKTCPEFLTLFLQVLDEGRLTDGQGRLVDFRNTVIIMTSNVGADLLSAEKGEISDATRKKVMDRFKEIRFPVEFLNRIEEIIMFRTMTQSVMEQILEKHLSDLQQREGIKRLRLNIDRKAKTWLIKIGISREYGARPLARVIQRELLNPLSQRLLEETIHEGDTVRIILNESQDGLYVMPNHDAPPPSELEPVAESSTRAGKRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR20</accession>
    <name>A0A401GR20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Septum-promoting GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0606410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615575.1">
        <property type="nucleotide sequence ID" value="XM_027759774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR20"/>
    <dbReference type="FunCoup" id="A0A401GR20">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GR20"/>
    <dbReference type="GeneID" id="38781579"/>
    <dbReference type="InParanoid" id="A0A401GR20"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037527">
        <property type="entry name" value="Small_GTPase_Tem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="220" mass="24417" checksum="3A01C34771D5C587" modified="2019-05-08" version="1">MSASSSSSPTPGSSTQSSRPSLENGNEPNSVVIKVGMLGDSQIGKTSLMVKYVEGHFDEDYIQTLGVNFMEKTITVRRTSITFSLWDLGGQREFVNMLPLVCNDAVAILFMFDLSRKSTLNSVKEWYRQARGFNKTAIPFLIGTKFDTFSAFPRDEQEEITKQAKRFAKAMHASLIFCSTSASINVQKIFKIVLAKAFDLKCVIPEIDGVGEPVLMYVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR92</accession>
    <name>A0A401GR92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607060</name>
        <name evidence="2" type="ORF">SCP_0607160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615639.1">
        <property type="nucleotide sequence ID" value="XM_027759838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR92"/>
    <dbReference type="GeneID" id="38781643"/>
    <dbReference type="InParanoid" id="A0A401GR92"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="5863" checksum="DCD214A53EB461BF" modified="2019-05-08" version="1">MRLDATDEDLALYRPLDKKDLHVKTAVIEASTSRLRNVNLAWFWTMDVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GST6</accession>
    <name>A0A401GST6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0607840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615717.1">
        <property type="nucleotide sequence ID" value="XM_027759916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GST6"/>
    <dbReference type="STRING" id="139825.A0A401GST6"/>
    <dbReference type="GeneID" id="38781721"/>
    <dbReference type="InParanoid" id="A0A401GST6"/>
    <dbReference type="OrthoDB" id="2794895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26509" checksum="BD8AE169E88EF2E8" modified="2019-05-08" version="1">MDIRWPSQAAAPYFRQVRLEANVGLGVLRLPYGVLCIKRDLYKDGRTVRSHPNLTVPDLFSHDANVGSADPAMIDHHDPNDAEKIQSGARSSTSGNLQEDKKEDFLDQIVPAVDDEDEHEGDQILGTGDPFPMDPNAPEEQQFTFRAVFVGCMFGAVISASNVYLGLKTGWTFGASLFGSIFGFAILKPLSKALPERFGGGYFGPKENVCCQGAATAAGSLGLLFTSLPRINSACLAQALNRISDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTC5</accession>
    <name>A0A401GTC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0706680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616394.1">
        <property type="nucleotide sequence ID" value="XM_027760593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTC5"/>
    <dbReference type="GeneID" id="38782398"/>
    <dbReference type="InParanoid" id="A0A401GTC5"/>
    <dbReference type="OrthoDB" id="3132318at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="9113" checksum="CB2655F1745D2CA3" modified="2019-05-08" version="1">MCRRIAEGTRWSKCGHFQRHLVVAVMDCNSSHCERSILHPKHCREPTCLKNYGPDVQKDIDTVKDDCFQCRAAAARTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTL0</accession>
    <name>A0A401GTL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0800630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616459.1">
        <property type="nucleotide sequence ID" value="XM_027760658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTL0"/>
    <dbReference type="STRING" id="139825.A0A401GTL0"/>
    <dbReference type="GeneID" id="38782463"/>
    <dbReference type="InParanoid" id="A0A401GTL0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38493" checksum="BDA3B9FEEF01FB1B" modified="2019-05-08" version="1">MSSKCAWKANPYLDIEAIVDNDEEEEEEEEEEEEEELAELLADVQCTQQARARLDNACVGDDAADAEAMARSITERDMAARRAQRASQSGGAVVSLAPDEIHLQAMENGFLSPWVCISRGTYKHDVAFVESREDSLLRVWVVLRLPTTKKRQHRRTSQQPMPPALLKELFREAVTESEGDRLIHILKGKKFKGGLLQLELTLDRVTFDVHATGNDVFIFNAAKFMPKTAIAKLILFCVDFEPAAGTRVIVIQGEQCCLIGVVHSVINGQATLTNLYHEKLDDELSSLVLPVTQLHPLWAVGDAVKVKTGLHAGLEGQVIAVDDFDVTIVHANKVEHVCSTYDDASKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUI7</accession>
    <name>A0A401GUI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616307.1">
        <property type="nucleotide sequence ID" value="XM_027760506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUI7"/>
    <dbReference type="GeneID" id="38782311"/>
    <dbReference type="InParanoid" id="A0A401GUI7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="67" mass="7563" checksum="0B88D4ACAFD94E34" modified="2019-05-08" version="1">MALSGRPALRRRDEVFRAMISFTEDALIFLTSVRRRLVSLLPAQATQAFKTGRVTPVSPPAQRQEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUV3</accession>
    <name>A0A401GUV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0805290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616918.1">
        <property type="nucleotide sequence ID" value="XM_027761117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUV3"/>
    <dbReference type="GeneID" id="38782922"/>
    <dbReference type="InParanoid" id="A0A401GUV3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="27372" checksum="46A15B14304C0AA5" modified="2019-05-08" version="1">MSIPASPTLVNGVPSRAQTPFIRTSSPSPSIELSHASDEQEFATRLVSAIRVPVDFTDILVALRNRPQDRQAVVSMQRALEMVEWMQTARQELIAAEERTSRARTRVDQVWSLMRSTVTRTAQEIWREHGDEDIGHILGYTTNGIPASTPRSSPEPIPVRPRPPRSHVPRMDVSPNKDHEPAGGHATDVEEIIMSATAPDDDEDHNISCGTRNVRRELMLQRSPLVARLFFFFSLFPLRYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVG1</accession>
    <name>A0A401GVG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin interacting protein 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0901000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617134.1">
        <property type="nucleotide sequence ID" value="XM_027761333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVG1"/>
    <dbReference type="FunCoup" id="A0A401GVG1">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVG1"/>
    <dbReference type="GeneID" id="38783138"/>
    <dbReference type="InParanoid" id="A0A401GVG1"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005519">
        <property type="term" value="F:cytoskeletal regulatory protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005613">
        <property type="entry name" value="AIP3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00806">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3 C-terminal" evidence="4">
        <location>
            <begin position="533"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="991"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="780"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111281" checksum="B31B967ADB651E7B" modified="2019-05-08" version="1">MSTARQPGHPSRRTNQSVSSTTSAASSRSDRLAPPEPSPQVETAVTRLLVSIKQLLEALTKWSKQEVSEMDVSDVYVRLGNDFNAAVAAFSLYRIEMSELASVPDDLRAILETCLSEDATPDVLSQYLPEVRKIITDLLQGLRSKQSIYRRIISDHKHRSSDAANGSDRESRSERTASRRDGTSVSSRAQVMRGHESSESSSRRSATSSRRGANPASPPVRNNADFVGGFAPPNMVDGDAPPPYRSSTPGPPPRSQLPETSSFPPSRARSASAVDATAGMVNGQQGVVNGQQGMSNGQHGMSNGQGAVNGQQSKGSPDLDVTPIARPQPQVPPSVKRYSLSDPPVGAPTPPPMVVVDEVNEESPSPATRPATPQSPPRDNVPMESFPAPAVQNSLAALKQSDALERRASKRFSTYNISKMTGGSIRGHGVGSNPNRRSLAVTGALTPGDLAVLTEVDEEPPVAMKRERSRPSQRSRNPSPIEEAPLIPPLPSSRGPSPQKPAVSDKPPEAAPAAEQPSVGGASDEASTSFPVFLQVGREVKKVIIEPPMTFGSLRVLFMDKFAYNPGKENFPAIYIRDPSSGVQYELEDPDEIKDKCLLSLNIEPLDQIKQHIDTQISSLAQDIKDLRAVVSSNRRASHPPPMIISQPLAESTPSTARPTERQFHNVARRLSRLLPDEGLPLVPQQTGSVIQPQMTGASVMSEYSTRVVEDLKTQFDEVQNLRRDLGIMRQLYTEFMKQTKESLGALRSQTQNVRQIATTKVAGTRSFINDGKAKLDSRSQNVLTRVEELQDIVENIKDDVLKRNVSPKPQILKKVRADMDATAEELRSLKEHIQTVKPMWKKTWEEELQNIVEEQQFLQHQEEFLGDLLEDHKAAEEVYGHVEKVISLRGNASARATRARGFKPPPMDEGHSGLSTVMLEIRGAAAVDPERRLKAIAANEKNREKELQSRSDEFQSELNGFVSGKRLKMTGGAEEVERVRQKRNEQTLKAMFTGPSPNTPSNSGLNSPAVEGARLSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVR1</accession>
    <name>A0A401GVR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617224.1">
        <property type="nucleotide sequence ID" value="XM_027761423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVR1"/>
    <dbReference type="GeneID" id="38783228"/>
    <dbReference type="InParanoid" id="A0A401GVR1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="160" mass="16831" checksum="10AD682A2D1CB664" modified="2019-05-08" version="1">MSSWGDTAFGTYTRPVSLLFGMEVSPLVSRLTLSMEALVVDDEVVAAVEAPSIPVFAGVGDGSTSGDLHDRDLTPIDAGGETALTALDVDDDFVWPTSPRPELVSLPDVSSDVQQGDDLSPIDICLVGFNEPINDVSTVKEASGSFLSVYIPIVESNSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVT3</accession>
    <name>A0A401GVT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C-factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0901710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617205.1">
        <property type="nucleotide sequence ID" value="XM_027761404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVT3"/>
    <dbReference type="GeneID" id="38783209"/>
    <dbReference type="InParanoid" id="A0A401GVT3"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26004" checksum="828AE87931FD4BFE" modified="2019-05-08" version="1">MASQSYVWLITGTSRGIGMEMTRQLLQSPMNTVIATCRNPAGATGLQALKTDLTLKGTLHVVQLDVADETSIRNSVKPVNEILSDRGIDYLYNNAATTEWFDTAFEHSYSGMIRTFQANVAGPALIAQLYIPYILRSSRKVIVNMSTGLASFGLNCGPKCVSYSISKTALNMLTYKQATDKPEIIAISLDPGWVKTEMGGEGALLEPSDSVAGIIKTLQGLTSENSGKFYRYNGESIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWG0</accession>
    <name>A0A401GWG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0806280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617017.1">
        <property type="nucleotide sequence ID" value="XM_027761216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWG0"/>
    <dbReference type="STRING" id="139825.A0A401GWG0"/>
    <dbReference type="GeneID" id="38783021"/>
    <dbReference type="InParanoid" id="A0A401GWG0"/>
    <dbReference type="OrthoDB" id="2754291at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="653"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE86104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1248" mass="137883" checksum="0A610E2F31147F83" modified="2019-05-08" version="1">MVKHCFRYQQTVTVEHSSYSFTSRRLLQQQGCEVSDLHDLVPYPAPLPFAHLSRIDSSLFSPDSINISLPLSPSSSPSSSRAPSLQPIMPIPHRLPRVMTTTIAKEFSDILKLAADRSNYRIWLGHIKCATGGCDTDELLDRAADPTSDVERKLNKQMLNAITGKFHDSLFKKYLNVKKVHEVMTGLKVEFGTSTAASEAWMKAKLFSLRCSDDHKVHQHLDQLAELKEKLSEMNVKIEDCTYINAITTFIPCSFASTVTAITTAVDIFNSTLAPGAACKVVTSTEIVTTLRAEADFRSVLKSGDKTTTASAAITGGCGGGRGRGRHGYRGRGNGSSKGNVPKSDDDLTCYKCGGKGHRAPNCPLKKQYYQRSKGKSEAAASSSGSTDTKPKADGKLKDNVKDTSASTVAVQSVSSVHIEEAWSASMVFSAPLEEIVIDCADLAAQDEVQISETYHAFARVAESDHRVDIFDTGASHHMTPHLDRLSNFCTTAPHQIRATNSEIFYSHGVGDLLMRLPAINGGRHIRLKGVLHAPAMHATLISLGLLDEAGFAWLGHEGTLTISNRENDVIASIPHEDNLYSIFYDSTSLASAVELSLFKIHKWLGHVNYAYLKAMLRHDRIAGITLDPQRADKTECRTCLVAKACHALIATVHQSPLAEKFGEHLHMDVWGSASVFTIDCCKYCLTLIDDVTCWLKMPLMRVKSEAFRKYVSFEVHLQTQHGVRTKILQSDRGGEFLSANMDAHLEYAGTVQKLTVHDTPEHNGVAERTHLTIFDGMRTALAGSGLPKWLWGEALAYIVYVHNRTACHALQGKSPFEVHFGHTLDVSNLHEWGEIREPVDPDIVTGKCSLMDISIDNDEECEVVAYSVGTAASDFLEFDPHSVAEAKHRPDWLKWQEVFRTKRDACGEVTGYCVHLVTQGFTQVEGINYFSDDTFAAVCKLASVCIILSVTARNGWYTHQVDVKSAYLYGKLCDDEKIYMRPPPDIELDRISPGQLLLLLIAIYRLKQLGRHCFADAKPLSQPMDTHAHLSVNQCPVTTAEYAIMHDKPYLEALGALQYVSVTTHPDITFAVGQLTQFGRNPDIVHWNALKCVYQYLKGTADLWLVLGDSEDNNIIGYSDADGMSTEGRRAVSGYIFMLNGGTVSWSSKCQDLVTLSTTKAEYIALTYVSKEALWLRSFVIELFGNPEHPIPLHSDNQSAITLSKDNHNKINLSYCPTEDMIADILTKALPSMKSKHFTLSIGLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWV7</accession>
    <name>A0A401GWV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0905980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617631.1">
        <property type="nucleotide sequence ID" value="XM_027761830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWV7"/>
    <dbReference type="STRING" id="139825.A0A401GWV7"/>
    <dbReference type="GeneID" id="38783635"/>
    <dbReference type="InParanoid" id="A0A401GWV7"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9092" checksum="7DBC74633E05157E" modified="2019-05-08" version="1">MKGTAVEAIGNLTGATSWQQSGKEEHAGGEAEYKASQAKGYAEGTMDVLGGKKDAVVGALTGDRTQETTGNARQDKGQMQQEFNKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXA7</accession>
    <name>A0A401GXA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1000650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617736.1">
        <property type="nucleotide sequence ID" value="XM_027761935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXA7"/>
    <dbReference type="GeneID" id="38783740"/>
    <dbReference type="InParanoid" id="A0A401GXA7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="119" mass="13816" checksum="6224D6308F59DE1D" modified="2019-05-08" version="1">MWKRSQIAKRAGDWCRKLEAFSRNYVSVWRPRRFLKASRAVAARPVVRRCTVIDSEPEVHSTLKIVVPSDERRLEARSRGVMRRPSDDAEKIVKTEIAKKTEVARKTEIAKKTEIAKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXN7</accession>
    <name>A0A401GXN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1002410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617908.1">
        <property type="nucleotide sequence ID" value="XM_027762107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXN7"/>
    <dbReference type="GeneID" id="38783912"/>
    <dbReference type="InParanoid" id="A0A401GXN7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="71" mass="8053" checksum="B4B75CFB70C173EE" modified="2019-05-08" version="1">MHFSPAVLFVLRTGNMVPVSISCPTLREAFRVCYLLLVQPFYSSRILLRTLPLKFVVPPGQPGFFIDVTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXQ9</accession>
    <name>A0A401GXQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="17">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phospholipid methyltransferase</fullName>
            <shortName evidence="17">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_1002610</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Endoplasmic reticulum membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="17"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617928.1">
        <property type="nucleotide sequence ID" value="XM_027762127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXQ9"/>
    <dbReference type="FunCoup" id="A0A401GXQ9">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXQ9"/>
    <dbReference type="GeneID" id="38783932"/>
    <dbReference type="InParanoid" id="A0A401GXQ9"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000005">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005444">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 17 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 17 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="17">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="17">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="17">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE87015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="200" mass="22507" checksum="7374C663BD8C1AC4" modified="2019-05-08" version="1">MLPFVDWSKESLWISVFSIAFNPTAWNIVARSEYRNKTITRLFGGNTRLGCYFLAILIFTFGIVRDSLYQKALEDQPRQSLLPEPYNVLVPGALFIVGQTFVLTSTWALGITGTFLGDYFGILMDSRVDGFPFNVLRDPMYVGSTMCFAAGALWYERPAGLLITLYVYVVYLIALRFEGPFTDMIYANHAATASASKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXY5</accession>
    <name>A0A401GXY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal mating-type pheromone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1003100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617976.1">
        <property type="nucleotide sequence ID" value="XM_027762175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXY5"/>
    <dbReference type="GeneID" id="38783980"/>
    <dbReference type="InParanoid" id="A0A401GXY5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="50" mass="4876" checksum="36773FE19C4C7E45" modified="2019-05-08" version="1">MDALFTIAAPVPAEEVETSVTAPMDFDTSGSGSGVNGGNGWSTSGGCIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY71</accession>
    <name>A0A401GY71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1003880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618054.1">
        <property type="nucleotide sequence ID" value="XM_027762253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY71"/>
    <dbReference type="STRING" id="139825.A0A401GY71"/>
    <dbReference type="GeneID" id="38784058"/>
    <dbReference type="InParanoid" id="A0A401GY71"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="2">
        <location>
            <begin position="141"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="631" mass="68703" checksum="3D7724241EA8F1F4" modified="2019-05-08" version="1">MESDQTKPFVEAKTTSTTGSKSAISQTSSSSTRPRLFWLCVASVLAGIAYRINLSGPEYKTVTQLPDSYALCSNNGTIYTVNEVEPVVDCMLVRKDKIIATGSLSSLQVQWEEYQNALIARFYGNEPSAKKPLTIIRPVPGSIVVPGLADAHAHLIMYGFKVELPLDGAETFNDVLDIIEDYVRSHPDVFADETRWVEGMGWDQTRWKGWRGGFPTAADLAIRPLLASRPLALHRVDGHALWVSPTALAFVNPGPGEIEGGEVVRYENGEMTGVFLDAAMALVPKPPRSAAQMKAYLERALTDALAVGLTSVHDADVEVDMIDVFKQVADEGKLPLRVYAMGHSNEPTYWGDKIPWLTGYGRDGRLNVRSVKLYTDGALGSWGAALLEPYSDNPGTSGLMRSDEAALNATVARFWEAGWGINIHCIGDRANKAVLDIFEGLLGNDTEQAHARRPRIEHAQIMRVGDIERAGRLGVITSVQPTHATSDMGYAESRLGRDRIKGGYAYQSLLQASPLKTLPLGSDFPVEGINPLLGFYAAVSRLDVNGNSPHGPGGWYPAERLTRAQALKGMTLDAAYAAFAEHELGSLEPEKKADFVVLDTDIMREDAPFTEILATKVRATVVDGQILYGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY93</accession>
    <name>A0A401GY93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1003760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618042.1">
        <property type="nucleotide sequence ID" value="XM_027762241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY93"/>
    <dbReference type="FunCoup" id="A0A401GY93">
        <property type="interactions" value="978"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GY93"/>
    <dbReference type="GeneID" id="38784046"/>
    <dbReference type="InParanoid" id="A0A401GY93"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE87129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="864" mass="94617" checksum="E0638E6ACE105A88" modified="2019-05-08" version="1">MNASELLANTLSPDAHTRSDATQKLESASRENYPAYMMMLSSELVKENSLTHVRNAAGLALKNALTARESARQLDYSNRWLSLPNEPRHKIKSDALTALSSSAGKVGTVAAQVVSAIAAVELPQGQWMDIIEILLSFVNDQTNMHLRVATLQAIGFICETIKPEILALRSNEILTAVIHGARKDEPSPEVQLAAITALLNSLEFVRDNFDREGERNYIMQVVCEATQNGSVPVQVGAFECLVRIMTLYYEKMGFYMERALFGLTVMGMKHSEESIALQAIEFWSTVCEIETELAWEASEASEYGEMPETESKFFAKIALPEIVPVLLQLLTHQEEDADEDEWNISMAAGTCLGLLAQAVGDTIVPAVIPFIEANIRASDWHLREAAVMTFGSILEGPDPNVLTPLVNQAFQILIDMMTDANIHVKDTVAWTLGRICDLLVTCIKTDVHLHPLISALVNGLQDNPRIVANCCWALMNLSDQLGYSEGDDPQAATTGPLSPYVDGIVQALLRVTETASNEANYRTAAYEAITSFVTHSTLDTITVVQGTAVSVLVRMEQLLSMQNQILGVDDRNNWNDLQSNFCSVIISVVRKLGEGIQPLADRIMTLVLQLIQVAGKTSTILEDAFLLVGALAAALEQRFSPYITAFLPFLYPALKAHEDTQLCTVAVGVIGDISRALGEQSTQYANAFMSVLLENLQSDVLNRNVKISILSCFGDIALAIGPAFEPYLSTTMGVLRQAGGVQPNPLDVDLVEYVGLLREGILEAYTGIVTGFKNTEQVTLLLPYVQGMLELTQLCLADSERTESSVKASIGLIGDLADSFPEGQIKQYLLAEWIASELRAKGRLPPETKKTLRWAREMVKRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ27</accession>
    <name>A0A401GZ27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1100850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618322.1">
        <property type="nucleotide sequence ID" value="XM_027762521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ27"/>
    <dbReference type="FunCoup" id="A0A401GZ27">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZ27"/>
    <dbReference type="GeneID" id="38784326"/>
    <dbReference type="InParanoid" id="A0A401GZ27"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="225"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="445" mass="50001" checksum="F33410A5F6631D3B" modified="2019-05-08" version="1">MASNQPHRGSPALAAETKPRGANRSTKVAGKLKVLPDQVEPALQDKQAEAQAPPKDKEEGEAPGSPESDEDEGDDEDEPEEDVEVYNQIDLIPAGSARRDALRLTKKKAKSLPRVTAYATAGSYRFPELMKFFNARRAAYHTNARIIHDVIYTPYAYEQPVEDPTASERHVHFQGQARPSQTGDLLGVPELVPEDNRVASDAEPPQVGKTKRKGKFSETPTEAEIFIFPYGTVVIWGMTEPQERRFLSSIKRFEEEKLAPDEVEMEDLNYYYANYSRIYNDVITLRRGSSYMTKLSLSHALSQSVKISLFEELISTTIEETKDIPEIISATGKIGMPHKDIMKKIGELFLLRSDINSVGSVLDSPEVFWTYPDLQPLYDAARGYLEIPQRINLLNTRVEVLQDMLQLLKETVSSRHAERLEQIVIALIVVEIVLGIITILVDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZB6</accession>
    <name>A0A401GZB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618405.1">
        <property type="nucleotide sequence ID" value="XM_027762604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZB6"/>
    <dbReference type="GeneID" id="38784409"/>
    <dbReference type="InParanoid" id="A0A401GZB6"/>
    <dbReference type="OrthoDB" id="3260716at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="280" mass="30917" checksum="BB2B5E689B7EE982" modified="2019-05-08" version="1">MFWKTFRLPSILAKLRNVESLIVDDTYQVIVPEYSEDSDSRDTCTLPTLFPKVKSIRLVPLATTSQQMKHVLSFLGSFRSLSSIVVECGIDLWYQIKDSPSLPLSEDEREPITITSSHLRTSIHSGIIVSLLLSKLFVPRLRMLRLEGIHPQHMAIRMPQKHLLPITGRDALLGTVPPESQNVHQIVPGELYSDILAARHARGLGSNTVIDCSPFATPTAVCDTLTGAMSKDVHTGLGHPGSGMSSAEMHHNGKPHRKRDRTGTGQYGGADDNRDVDLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZU8</accession>
    <name>A0A401GZU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1103680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618604.1">
        <property type="nucleotide sequence ID" value="XM_027762803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZU8"/>
    <dbReference type="STRING" id="139825.A0A401GZU8"/>
    <dbReference type="GeneID" id="38784608"/>
    <dbReference type="InParanoid" id="A0A401GZU8"/>
    <dbReference type="OrthoDB" id="3067694at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="242" mass="26959" checksum="FF94BA7FBDC313BC" modified="2019-05-08" version="1">MKHGLFLNPSRGDPQFFEPGPVGDIVSQMGTRQICLMFGFSGQSKVAEAEARPDSEKWYKYIRLLPLNQEWERYIAFMATNIGQDGFYMPTGRKQASMEFSTKWGKMGAGNGEDDDEDELFAVLKGAKFGKSQSGHASSSRTPGNIITGHSITPLALNHWDQIAVYDCTRFFQGKDSRKLNESFDLAKVRATCPLWKKEVPVGSFICVLHSPVKWMAAAKTDNPKLSLSLNLLAICIIVSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZX7</accession>
    <name>A0A401GZX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1104040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618640.1">
        <property type="nucleotide sequence ID" value="XM_027762839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZX7"/>
    <dbReference type="GeneID" id="38784644"/>
    <dbReference type="InParanoid" id="A0A401GZX7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="12087" checksum="264F78D1E40EDA45" modified="2019-05-08" version="1">MAEMNSTENAKKQKTVMLVAQVSDHQMRIEVLEGEKELLRMEMESFKTVAETYEKCLETAIDRLDKQARLIGGLQDLASELQAQNSYLARPSPFEIFSYLMLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H066</accession>
    <name>A0A401H066_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1200400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618728.1">
        <property type="nucleotide sequence ID" value="XM_027762927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H066"/>
    <dbReference type="GeneID" id="38784732"/>
    <dbReference type="InParanoid" id="A0A401H066"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="417" mass="46042" checksum="5C6F662D22D5D08E" modified="2019-05-08" version="1">MGRSLRLNTYMQALDEELAFNANPYVSSYYPNTSNPFPEVPSPIFNSSPESTSSFDSFADVVSATTDFNSSVPSTELMLGLMTPSGTSLALPQFGHIDNDNFGIPVHLTSHRLSFVPRHFFPVGPSDGHNQATYSSCSGNTYSGHHRNAADNYYHTPSSASYTSSVSYTSSTSYTSSVSYGYPPLPEFSLVRVPVWGSSPSPSQQAWDSEQDMDGEHDGSESEDEYVPSRPSCAKPSRCSRAEPSRCSPKPSRLSRAKPSCPAQARRQTARTRRYAPYALAESSTVPSSSSQFRRTASRNEQFDEAVRPPPAGTTECEYCGASYKRWSDLNRHVRSHSKKALRILCGGLPKAEAIRAGVTVEAKMPFVHEGVEYYGGCMTEFTRKDSLSRHLLRSRRCVGSITIYNLERTRRVGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0F7</accession>
    <name>A0A401H0F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aconitate-delta-isomerase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1201320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618820.1">
        <property type="nucleotide sequence ID" value="XM_027763019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0F7"/>
    <dbReference type="SMR" id="A0A401H0F7"/>
    <dbReference type="STRING" id="139825.A0A401H0F7"/>
    <dbReference type="GeneID" id="38784824"/>
    <dbReference type="InParanoid" id="A0A401H0F7"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="415" mass="44494" checksum="2C7D64FC5D1B7577" modified="2019-05-08" version="1">MFPLRRSVAQVAVFNPKAYASTFVTRNPLPATFLRGGTSKGIYLNRADLPEDRTQWDRIFLGIMGSPDAEYGRQLNGMGGGVSSLSKICVVGAPSDEQRAQGFDVEYTFVQVGIRDSALDYSGNCGNLSSMIGVFAIDEGLYHPAGAHAGPTVTVRSFNTNTRKRIDTTFPVAVAEDRNCVPVLDLEQVYMAGVPGKASQITLDFMSPGGARTGHLLPSGAPIDTFSVRGENKDFVPIDISLVDATNPTVFVPEDSIAKLFPSLLLPNLADADFNADLKHTIEEIRMRGAVRMGLDPTAQAQPKICLLSPPAYDDVDAADIVVRAFSMGVLHKAIPMTVGLCLGVAAGVRNTLPWQIVTQARKARGVDDPVGELVRIRHPGGIVDVGASFGADGQVLSAKVVRTGRRLMKGVVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Q6</accession>
    <name>A0A401H0Q6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1202330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618920.1">
        <property type="nucleotide sequence ID" value="XM_027763119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Q6"/>
    <dbReference type="FunCoup" id="A0A401H0Q6">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0Q6"/>
    <dbReference type="GeneID" id="38784924"/>
    <dbReference type="InParanoid" id="A0A401H0Q6"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="425"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="785" mass="90173" checksum="9222534B10F611F8" modified="2019-05-08" version="1">MATSARMRGKPRIKPAKKHGPDFSIDETWSKLSHNIVEIQKHHAENLSYEENHRFAYNMVLYKHGETLYKGTCKLIAENLDKLAKEQLVPTFPTVTADDPVQKSQAWETFLKALRKVWDDHTSSLSKLRDVLKYMDRVYTKTANVPEIWDAGLLLFLEHIIRPPIEDHIISAVLNQIQTERDGYVINRSAVKGCVDVLLQLYDEHEVAPVYNRHLEPSILKESESFYRKEGEDLLETCDAPEYLRRVESRFDSEESRAHHFLSSYTSLPLRRILENNLIKPHLSGIIAMANSGLDVMIDSDKLDDLARLYRLFIMVPEGLPCLKKALRETIVRRGKDINAASLSTELEDPSVDAEIEGAKGKGKGKARATNTGAQTLQVALKWVQDVLDLKDKFDNIWSRSFRSDRDLESGTNEAFESFINVHEKSPEFISLFIDENLKKGLKGKTDTEVDITLDKTITVFRYLTDKDVFERYYKGHLAKRLLLGRSVSDDAERGMLAKLKIECGYQFTQKLEGMFHDMKISADTMQAYQDHLSRTTAPDIDISVTVMTSTFWPMSYSGVSCVFPDQLIRSTKSFEQFYLSRHSGRRLTFQPSLGNADVRVSFNTKKHDLNVSTFALVILLLFENLGDGEFLTYEEIKTATSIPDPELQRNLQSLACAKYKVLRKHPPGRDVNLDDSFSFNADFNAPLQKIKISTVASRVENSDERKETKDRIEEERRHQTEACIVRIMKDRRHMTHNDLVNEATRQLSSRFQPNPLSIKKRIEGLIEREYLERCSDHKSYNYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1I2</accession>
    <name>A0A401H1I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotically up-regulated gene 14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619209.1">
        <property type="nucleotide sequence ID" value="XM_027763408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1I2"/>
    <dbReference type="FunCoup" id="A0A401H1I2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1I2"/>
    <dbReference type="GeneID" id="38785213"/>
    <dbReference type="InParanoid" id="A0A401H1I2"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="276" mass="30400" checksum="07B575D16142C65C" modified="2019-05-08" version="1">MSKRSDRTLNPAIGASTEFVPPSFESKLQEREFLKYRLAQAFRIFGHEGYNEGVAGHITLRDPVRPDCFWVNPFGLHFSLIQPSDLLLVDHDGKFQDESGPLRLLNRAAYMIHSAVHAARPDVICAAHTHSIYGRAFSTLGKELDIITQDSCAFYNDHVLYDRFGGVVLEEEEGKRIAECLESKKAAILQNHGLLVASPTIEATVHFYIALEKSCQVQLLADAAAKATGTVKIPLDEAAYTAQIVGSPRTGWFSGLPHFKALEAREGVSFEAGKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1X9</accession>
    <name>A0A401H1X9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1302710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619369.1">
        <property type="nucleotide sequence ID" value="XM_027763568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1X9"/>
    <dbReference type="FunCoup" id="A0A401H1X9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1X9"/>
    <dbReference type="GeneID" id="38785373"/>
    <dbReference type="InParanoid" id="A0A401H1X9"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="69"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="71"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="434"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="479" mass="52382" checksum="FEF804D4BA680A8D" modified="2019-05-08" version="1">MGSSSKQVTNSLAGDDDLLPESSASSPSSVSGFLRGASEDTAISTDTASPSLSIDNPSSASTHSKSFAAKGKRKRSRVTPEQLSHLERFFASDRSPTAARRKEISGLLGMHERQTQIWFQNRRAKAKLQDVKIKGRAGLSDPPPDTPPELCSGFDIDLYNLIHEDEPVTIIPCTDLSIGTWRRVASTVSKHDLVGYVCQAKRCITWFIYSSGLGFKIEISFDIVVDTEFTNVSPGVALAALKLSQPPAFYLEHSASSGVNSSSVRYWKRCADWTEGMQATRVLRHEVIGSEMQLSHIIRNFSPNGTVAEVSLYSLPQRAEASPVLHPTSSLPLAHEDHCRDDMSQYDAQYPNGSRQRLLAAGPSHPLQNFITAPAGCSPPYPADLPYPHVVRTFPPMHLPSSYNMCDGDRKPPHYALQFEPHLGFPRRMSSFPHSHAPIPQYPSACTNDSSPRSVSPYECPNDLVSSASTSHSSFDAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2C8</accession>
    <name>A0A401H2C8_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1303910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619487.1">
        <property type="nucleotide sequence ID" value="XM_027763686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2C8"/>
    <dbReference type="STRING" id="139825.A0A401H2C8"/>
    <dbReference type="GeneID" id="38785491"/>
    <dbReference type="InParanoid" id="A0A401H2C8"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="369" mass="43161" checksum="EEC5C0E14CCE2FC4" modified="2019-05-08" version="1">MDAFFAYSQALGLMYGGVTEYIDLIERFENGDVVFEPVEVFDDPDPLPTFEEPVEAVLGKRQREEEEEEDDEDDDNEEEEDDDDEDEDDDDDDEDDDDEDEDEDEDEDEDEDEDEHEDKVDDYEDGKEEKEAEVGKHGDYHVPVKEEEEEEEEEEPEPEEDMQVEVESGREKEEEGEEDKEDKDDEEYVDVAAEEAYVDHKKRQTGRKIHSVVPSGEGRMGSQPPRKRQRLVKNKTAQRTKVGREKRTVVCLVESCQLKGTVKSRERHMLAEHFEGENKLWHCPTCRKLLSRPDGLRRHCNLFPQCNAKAPRRVDGIIDYNACMAFKHPWHRKGPLRRLRAPLPEHRDPLEQELTMLREELGVEPWSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H321</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">SCP_1402090</name>
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    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619717.1">
        <property type="nucleotide sequence ID" value="XM_027763916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H321"/>
    <dbReference type="GeneID" id="38785721"/>
    <dbReference type="InParanoid" id="A0A401H321"/>
    <dbReference type="Proteomes" id="UP000287166">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7844" checksum="37CC640899EA51C3" modified="2019-05-08" version="1">MEDRCREPDETRERAESTNTVSDYTSRGMVPRVTNFVARGAERLWSHVRGIWAVTGTTPISVMFEKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3H2</accession>
    <name>A0A401H3H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619891.1">
        <property type="nucleotide sequence ID" value="XM_027764090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3H2"/>
    <dbReference type="STRING" id="139825.A0A401H3H2"/>
    <dbReference type="GeneID" id="38785895"/>
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    <dbReference type="OrthoDB" id="2753342at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="39527" checksum="0586218F61DFC3E9" modified="2019-05-08" version="1">MYDIPLVSANLASVPLVSLFYGIFVVFFCTSSYLMVRRQGRLNVGTSRLKSIWKMPLFIAGILLFITITGHWILLVHRSFMAFVYFDGGASPLEFYMNVGAVTAIAEIVFLVSTLTIENAVIVYRLWIIWKHNKYVMIIPVCSFLVNVACHVVVVYQYAQYHMGQNVFGASIGRWVTIDYVCSLCTNLYCCVLIVWRLWRVSHRSEPVVGTCMLWTLSVFIESAAFDVALLIVSMVLYELGLNVQYIIGVMMSPLSGITFMLINVRVGMGYAMHSQEEDVNGPTIRPSEARQGGHTTMFAMDPLVIDISQPVEHHLRQAAISVERSRFAECKNADGKGYDMGRDGSAMDSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3P1</accession>
    <name>A0A401H3P1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619947.1">
        <property type="nucleotide sequence ID" value="XM_027764146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3P1"/>
    <dbReference type="STRING" id="139825.A0A401H3P1"/>
    <dbReference type="GeneID" id="38785951"/>
    <dbReference type="InParanoid" id="A0A401H3P1"/>
    <dbReference type="OrthoDB" id="2782214at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32475" checksum="A34ADB7C98A96F54" modified="2019-05-08" version="1">MDTNTATISNVPHKRCRSSEARNVKAPKTEDAEDVSCARNAATGGSHGLLSDEDDLTPSGGAASITTPRSTRGDVHAIAANQSLAAPTPSSTDHRSSPPASPAHQVHCVLAPPLIPRNLALAPLRSGLLPTFTATVKVDGLDDPSLSDIGPSGVGGCPTSPVPLPSQSSPPSPSSPPPSSMPQDLPPPEVQEQPYRPNYFRSPPVPCQWGGVCGIGLDDVSPGGILRHLREYHPEEKLDKQTRGRCLWSTGYDALCERPMMQSNYGKHIAEIHVRSMAVECPSCRKSFSRPDVLEKHRNGRCKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Q0</accession>
    <name>A0A401H3Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Sparassidaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619944.1">
        <property type="nucleotide sequence ID" value="XM_027764143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Q0"/>
    <dbReference type="GeneID" id="38785948"/>
    <dbReference type="InParanoid" id="A0A401H3Q0"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="156" mass="17403" checksum="98D9D3A561D1B483" modified="2019-05-08" version="1">MDPIAKPNEGPYDARYLLHIVAIGHRYASQSSRLLHQLFPASLHTRLYQFRMPFFHHEGEEARAHAQVTGSHQAHLSHEVIAAAASYEAAKAYEKHCEANGKPANHKEATELLAALTGGFIDRLVETRGLDFIDKEKAKRDAHHRAQTGLSNAGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H470</accession>
    <name>A0A401H470_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1502360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620141.1">
        <property type="nucleotide sequence ID" value="XM_027764340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H470"/>
    <dbReference type="STRING" id="139825.A0A401H470"/>
    <dbReference type="GeneID" id="38786145"/>
    <dbReference type="InParanoid" id="A0A401H470"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="293" mass="32642" checksum="FF59BD6164D3DB36" modified="2019-05-08" version="1">MLTRSAGRKTRSSTKGVNTGGGDKEVSRSVSSRSKPAGSRKTKKALDDDARPAKKPRILEKTIQEPVAEVANSGRPSGLTESDFRQREVTHPVAGSSRDQDDAIRKKIEEYELRQRSLKCERDEFQAEVAELRKSEDSLNKREEDVTKKEEALARTEAKLNERDAAVVKREQEAEELIGSVIGSPAEQVLAQLEESFTCTLCFDVMLVDKLLTDLIDVLHKSGPAVGTSAHAKRNQKAAEAGDPTAAWREGGSARAEWKERERKGRDEMRLLTANWSKLRPLDFRAIRDRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H482</accession>
    <name>A0A401H482_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1501670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620073.1">
        <property type="nucleotide sequence ID" value="XM_027764272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H482"/>
    <dbReference type="FunCoup" id="A0A401H482">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H482"/>
    <dbReference type="GeneID" id="38786077"/>
    <dbReference type="InParanoid" id="A0A401H482"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="302"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="530"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="592" mass="66253" checksum="5FED60D746860D6E" modified="2019-05-08" version="1">MSLPEYDVGAVVIPSEDQHYSEYIAQCDERRAFISGFDGSAGCAIVTSRDAFLFTDGRYFLQAEQQLDKNWTLMKQGLPDVPTWQEFLSKRLDRNTRIGIDPTLITATDAENVQKALASTDSRLISLPRNLVDLVWKDRPPRPAKKIFPLDVKYSGESHMEKIKKVRGELKNKKLQAIVINMLDEVAWLFNLRGSDIDFNPVFFAYAIVTHEKALLFVNAAQVDEAVLSHLGPEVETHPYDTFFSHLKELGAELGLNNTAQVLVSDKTSLAIVDAIGSDHILVSRSPVTDLKSIKNNTEIEGFRQSHIRDGAALVRYFAWLEEQLNGGAELTESQVADQLENYRSELDLFRGLSFPTISSTGPNGAIIHYTPDPKDCAIVRKDQVYLCDSGGQYFDGTTDVTRTLHFGIPTAEEKRAFTRVLQGHIAIDTAIFPNGTTGYIIDSFARRPLWEDGLDFRHGTGHGVGHYLNVHEGPHGIGVRIAYNSTPLRNGMTVSNEPGYYADSRFGIRIEDVVIVREAQTPNNFGEKGYLCFEHVTMCPIQKNLIDGALLSPRERTWLDAYHAEVLRKVSPLLQNDGRALAWLQRECAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4E6</accession>
    <name>A0A401H4E6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1502900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620195.1">
        <property type="nucleotide sequence ID" value="XM_027764394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4E6"/>
    <dbReference type="STRING" id="139825.A0A401H4E6"/>
    <dbReference type="GeneID" id="38786199"/>
    <dbReference type="InParanoid" id="A0A401H4E6"/>
    <dbReference type="OrthoDB" id="2794869at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="59325" checksum="03C5455C87AF15C3" modified="2019-05-08" version="1">MDKPTFMQKDGRMAASHQYDPCNAISGTSSTNFSPMISVKTKHRSITDLPIDILIEIFKYIYSFSQILEEHAEWPYQDNSSDSHLKLVSTRWDERVDLRGSTLFPDALASVCRLWRDALQLVSVFWTRVVVFVDDDPTPMSMLGSRLELSASHPLHITIMRRPTSHRDADPLERRRVSDTMCLLYPHISRWYRFHINVLHASSLPVPHVELQGDALCLFERRFESQIDEIQYDVADWMPRFNAPALTELRMDGLTFRRAFLFSPASISHVQELSITRYARGHRLLFTFRNLIDCLCALPNLTWLDLVDLDILPEVGTGPILGLSRCRPRYCKFELLSSAITRLLSLCLQNAIYDLSLTQCTIPHRIDLSSVGDLRLQNIDHDQDLEPLLLNWDSVHLCVHSCPGFGASLLSAMAYEIDGHDNWLCPRLTILELLDCTNFTSADMRAMVQARHKAHAESGFADDFDDEFTVTSLTHLTVVGDMELWLADREWLDQNVDYVSWNGWCGGYARQTVYHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H559</accession>
    <name>A0A401H559_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1602140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620465.1">
        <property type="nucleotide sequence ID" value="XM_027764664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H559"/>
    <dbReference type="STRING" id="139825.A0A401H559"/>
    <dbReference type="GeneID" id="38786469"/>
    <dbReference type="InParanoid" id="A0A401H559"/>
    <dbReference type="OrthoDB" id="3044497at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="330"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="812"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1134" mass="127293" checksum="595566C7F9BF3D1B" modified="2019-05-08" version="1">MAQPLLDNIAAFDLSMLLPQGIPTLEATLTKNYTRPDNIFASTDIADRLLTCDTAPALRPPCTDHLPISLSLDVTPHPARETPRRNFREVDWEDFRTCLKGNIDSRMLGHGELTTLEQFNVVLKNLSDAISETIKATVPLSRPPPFTKRWWSQDLAKSRRAVQRLARVSYKHRNTHDHPSHAEYRKIRNRYGDEIKSAKQDHWEAWLESADPDSIWTINRFTAAGPSDGSRPRVPSLKDGNAPAAEENEAKSGILYRAFFPPPGPPPSLPATHRYPKLAFHFSPITDEQIAAAVKRLKELKVPGPDEASNEVYKHCIDLLLLHLGRLFRATFTLNTYPSEWKISNTAALRKPGRPDYAVAKAYRPIALLNCIGKILSACVADVLVYESETHGLLARNHFGGRPGRCSTDSLHLLVKTVKDAWRRGQVVSILFLDIKAAFPSANLERLFHNMRSRGIPKEIVNWLRQRLTGRHTRILFDDFKSALFEIINGIDQGCPLSVILYEFYNSDLFEIAYRIPHSFALGYIDDAAIIATGKDYIETHEILRRYMDEEGGAMTWSNEHQSEFSLDKFGLLNMSAMSPDLGPSLQLQTANIQPLEAHKFLGVTIDRRLRFHQQVAGALAKGFAWVQQFRRLARTSGGIPFSHMRRLYLSIAVPRILYAADVFLVPLRNVPGRKSTYGSVGAIKKLARVQRQATLLIMGAMRTTASDVLEAHANLLPFALLIDKHCHRAAVHLCTLPPSHPLHVHVKKASARYIKHHRSPLHELLETYQLDPDKTETISPIRYSPSWSPSFQVSVADSKDSALKEEARWAEKHGIRVYSDGSDIDSGVGAAAVLYRGDRANPKVLRFYLGKSSEHTVYEAEVVGFILGVKLIHSEFVVYSASCAGDNKASVRATRLRRPAPSHYLLDVLHRDVDLLIRKHKIGKSALTVRWVPGHKDVEGNERADLEAKKAARGDPSPLAMLPKSLQSPLPLSSSKLRQSHLECLKSKAATAWKGSERGHAFSRIDPSLPSPKFEKLVADLPRRHASLLIQLRTGHAPLNVHLHRIKCSPTKLCPACNGRPESVQHFLLSCPSYRRQRDVLTQELGRPARSLAKLLTSPRAVKPLFRYIHATGRFSTVFNHLNTFDKCRHARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5K7</accession>
    <name>A0A401H5K7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1700520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620641.1">
        <property type="nucleotide sequence ID" value="XM_027764840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5K7"/>
    <dbReference type="GeneID" id="38786645"/>
    <dbReference type="InParanoid" id="A0A401H5K7"/>
    <dbReference type="OrthoDB" id="2746456at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="459"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="795" mass="86462" checksum="E7FD15515055CF8F" modified="2019-05-08" version="1">MSPPPSSATGPAQDDMKEDDADFLLEEDDSNVELQRVLMSQHEKSLGGVDGVDNGDGDGDATNVDLQRVLIEEHEQRGALSPENAQPETKVDSASPRSSPDLDLPDVSQILADNQQPAGHTTKPPSLALSCSRGFATPSRPTHAIRQNETSPSDDDDQLLPSGDDDSKEDGGNIPTQSRTSLRGLKKTAQPSDQSDALLQSTPSGRSTAHSARPPEAPVSPAISRLKSKNEPGNTPDRKAVSPTATPVRASYRLSHNVTTTPSGSKSRKRRAKSPASQGGSPDSERRSRTRRRVEPNVLDTAVGTTLTPKTAQKSTSSSNSKPASSRTQSGSSTARTSSDPQTATQGPSGLVIKPPLSTHSFSQPVFGKSSLSPSAPRPTPKHRAQTQLSPGQDIDVKPEVPKSASSTVFPRMTLASTSSLLSQAKDEVERSASQRSRRGSISKAARITRHEEFWHLDGSVVVLIETIAFKLHRSRLSVQSEFFKRLFSNSPPPQAIAVDIDGASGSNAEDNEVQEVNVPMFSGCPLYTLTNVTVQDFVELLKAEKLGIAYAFNPPPSPILAAILRAAYALEFGTILEFATHRLQALWPSDLAQLTPDSIPHAAEAIVLARQCNLPQVCKRAFYELLRSPSFEQEADGDNDEDDDNDMYVDEQEEAGRRLQHADLVRLISTREKLRSEWLRVVCTPPVPSVVPCPLEQIPSDMRDPEREPELVRCRATREKNSELWMRAVLNGPTLVESGTYDPLCALQTLCDMDWADMGYCHGCVGARRELWGEKREKLWKDLDAWLGLPMATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5Q6</accession>
    <name>A0A401H5Q6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhamnolipids biosynthesis 3-oxoacyl-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1701030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620691.1">
        <property type="nucleotide sequence ID" value="XM_027764890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5Q6"/>
    <dbReference type="STRING" id="139825.A0A401H5Q6"/>
    <dbReference type="GeneID" id="38786695"/>
    <dbReference type="InParanoid" id="A0A401H5Q6"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="283" mass="29624" checksum="57E5DB0C323A2B44" modified="2019-05-08" version="1">MSASIAEDLRIDRLYGVEGKVAVVTGGGSGIGTMIASAFVQNGAKVYIAARKEKQLQEVCSALNEKGPGSCHYFIADLTTKAGCDSLVAAIKERESKIHILVNNSGISWGAPYDSFPEKEGWDRLMALNVKSVFYMTVGLTDLLAKGSTNVDPGRVINVSSVASLIATSTETSLAAKGSGLWSYATSKAAVNHLTSQLAVTLLPKRITVNAILPGTFPSKMTAYGFKTKGDSLDSNNPMGRVGHPRDIAGIVLFLASPASAYITGAHITVDGGSVVSRQKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6M0</accession>
    <name>A0A401H6M0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1801220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621011.1">
        <property type="nucleotide sequence ID" value="XM_027765210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6M0"/>
    <dbReference type="STRING" id="139825.A0A401H6M0"/>
    <dbReference type="GeneID" id="38787015"/>
    <dbReference type="InParanoid" id="A0A401H6M0"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4470" evidence="2">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="962" mass="108297" checksum="D5E2339D05D88239" modified="2019-05-08" version="1">MAAKKAVVLKNRGNDFFKSGRLSEAASLYSEAEKLSPSDPVYASNLSAALYEASNYPECIDAIIRSYKLINSGSNSVLASKLSARLCKALCHGLRSGAISDKFIRERADDISRLETVLSGSAESDPKSSQVWQLFRAIESESGDRRQTGSDALGRLSCLPVFKKPPSFWVDYHTIGQDSVMSMIDDAGPESPSRLDLSKMSDDELGDIAFMFGGIGDARHVFGTIYRLQKVCKELPQDKRDKVHMHMTLLDFHPGALARDLCVLMLLHDLVEAEATDPIALAEMKATLFYTYVGIAMPEYCHERLQNVIKDLQSRLSERPSRFPSWIHVDTEAVPGILEALKVWSTIADNTNTAQMLAAHHPISAGKSPLDFLDDPKISPAYKQMIEKNLADKRLKATEVVRALPPETLEKMGLVDPGPDATPRQKRLYKECFQGVVDSTLELVFSGTGTMSVEKMWYDQNKVFLPPPELWSRHPGFEDFAAFKNQLKKAKPSMAKSWKKHIEQTWKPNPTLYDYRHPGREPFLGFNPWNTPGCIDKFNVRFGFNTISPHTIYADAPTYTHLADFFGAVADSLKILKGQLKLELLFAELTQESVKMRFNSDHTRSPEFPRTFTRSYVSNVPDYTHGTINMLLYSLPLVRCGRESVVSAHSLLNTGIWRDDEEFIYTYTLLRSTDIPRYFGCRLISKEAVHRLVVLGNKPLPRPLSELATREELVVWLTRTLIYTVIPGTSGLGYFRAKMPNNLIPFFTLLVHLHSVGYPAHWLSEFLQCILDDDLTTDIAPYLDKWPIPVSDINRRVPKRKIRLDILHAEFENVLALSHRGFPFAISLPADFVTSHKEVGVFEASVRSSSPMLSSPSSSIPPFDPAVYLLFYKPAPNLTASAVVTALPSILDGKMEPPPGEIYILTAQETFDLDARKVSWMLSKRRARKMKREGWVMVAYRTDCKEPMTHPVPASQWEDTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6R2</accession>
    <name>A0A401H6R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable oxalate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1801620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621051.1">
        <property type="nucleotide sequence ID" value="XM_027765250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6R2"/>
    <dbReference type="STRING" id="139825.A0A401H6R2"/>
    <dbReference type="GeneID" id="38787055"/>
    <dbReference type="InParanoid" id="A0A401H6R2"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019452419" evidence="4">
        <location>
            <begin position="21"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="107"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="286"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE90138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="445" mass="48026" checksum="CC9DF9FF08A85859" modified="2019-05-08" version="1">MSRLFVSVFCAIVLSSLAVAAPANSIAASGTAVSSAAEPSETVPLAIDDPNYVEWVPDTDANPEPIRGTLGATIIAQTNIPLEDQNPDLLAPPTTDSGLIPNVKWPFSLSKNRMQTGGWARQQNIQVMPIATSMAGVDMRLEAGAIRELHWHTTAEWAYVLSGAVQVTSVDTNGQNYLGTANTGDLWYFPPGIPHSLQATNETAAGAEFLLVFDNGDFSEDSTFQVTDWMAHVPKEVIAKNFGISMAAFDHIPAEQLYIFPGPDPAPDAENLVEDPQGQVPSPFTFALSQMAPTQLQGGTVKIADSTIFQVATSIAVAEVTVEPGGMREMHWHPTQDEWAYFLSGNARVTLFASSATANTYNFQAGDIGFVPASYGHYVENIGNDTLHYLEIFNTDRYQDISLNQWLALTPPELVKAHLQLSDETISMLSKTKLTVVGPPKNSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G506</accession>
    <name>A0A401G506_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0101190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608159.1">
        <property type="nucleotide sequence ID" value="XM_027752358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G506"/>
    <dbReference type="GeneID" id="38774163"/>
    <dbReference type="InParanoid" id="A0A401G506"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="585" mass="64366" checksum="F8D54F1DEAC7F283" modified="2019-05-08" version="1">MPLKPTNLDIWPASGVCPICKRQTTSLRSHYSSIHRLICKVRYASDPKIQVKIVRDSRDNLFHCLGCVYKHASPRSLQRHAASCTFVMLPLRIRLPGLRRPAAEKNSEEEIQFLYIRKPSDSQVDDFEMHEVDGMLKTEPTDSDTLDEMNQQPEMDVDVEDEMHADTEGGSSRQKTMYEEEEEIYSGPGPNQECQIVSQGSPERQSSASQYHDSKSPPPPATLSLPSASSNHKTLSPVTDTPQQTDQTNPCEACTSSDRVIVDTEALHVSGDDLPSDQICASTDRECDTVRNESSHVQQPTPPLSSPALSPADYMRATPSVLKTVDPSTGSRSSIQSRRSLAFSPISRTPSLIIGRSSRGTEQPSFADRLPSATAAASGSGPHVSSIPRSLSYCSISSDISIKVETSQPSPAQSFVAGLSSSPGVSFLADILSGLGFDTDVLLDALSCTEDEWCKVKAEVLRRGRFADWCILSLGLQSRSEQLARFSLDVDEDELGKKCDSAASFIKGLSTSDRHAYLSTALSDLGFDREDLLDALCRLKEDVEWITIKDKIYENGGQFGFADWVLVKWGLRRRLGRLNRSRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5A0</accession>
    <name>A0A401G5A0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0102070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608247.1">
        <property type="nucleotide sequence ID" value="XM_027752446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5A0"/>
    <dbReference type="FunCoup" id="A0A401G5A0">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5A0"/>
    <dbReference type="GeneID" id="38774251"/>
    <dbReference type="InParanoid" id="A0A401G5A0"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13592">
        <property type="entry name" value="PBP2_HisGL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="58"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="227"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE77334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="32670" checksum="EBB583737EBFEF6D" modified="2019-05-08" version="1">MNAESLDGRLLFAIPKKGRLHEKCLELLVGADIQFRRHQRLDVCLVKNHPIALVFLPASDIPSFVGKGNVDLGITGQDVIIEAKMEKHITEVLQLGFGKCALQVQVPEAGPIQTSEALAGKRVVTSFEVLSGQYFSKIDDSLQLTGENRTKIEYVGGSVEAACALGLADGIVDLVESGDTMRAAGLHAIATVQQTEAVLIKSSKPKHEYLEPLIKLITSRIAGVVAAGKYVVCEYNILRSKLHAATSITPGRRAPTISPLEDEEWVAVSSMVEKSKTADVMDKLVTIGAEDILIFNLDNCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5L3</accession>
    <name>A0A401G5L3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0103240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608362.1">
        <property type="nucleotide sequence ID" value="XM_027752561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5L3"/>
    <dbReference type="FunCoup" id="A0A401G5L3">
        <property type="interactions" value="751"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5L3"/>
    <dbReference type="GeneID" id="38774366"/>
    <dbReference type="InParanoid" id="A0A401G5L3"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="110"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE77449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="423" mass="47123" checksum="22C76823C79F4055" modified="2019-05-08" version="1">MTGEVKAKEEAIPPAVVDDDDLDEEEDGVAEVHPSGGDAKKKKKKKKPKKKKVEQSDPPRIGLSKFFHDGIYPEGELQEYKDDNAWRITSEEMRYNERVANEDPETTYQDIRRGAEVHRQVRRYARKMIKPGMSMTEIAENIENGIRALVEENGLESGVGFPTGLNLNNCAAHYSPNAGDTVVLQQSDVLKVDFGVHVKGRILDSAFTLTFEPTYDKLLEAVKAATDTGIREAGIDVRLGEIGGAIQETMESYEVEVNGKAYPVKAIENLSGHSINKYQIHGGKGGKSILLVKNDDQTKMEEGEYFAIETFGSTGRGRVVENGDVSHYARVVDAPHVPLRLTSAKTLLKSINKNFGTLPFCRRYLDRLGETKYLLALNHLVSQGIVQDYPPLCDQRGAMTAQFEHTILLRPTRKEVVSRGEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5Q3</accession>
    <name>A0A401G5Q3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0103670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608405.1">
        <property type="nucleotide sequence ID" value="XM_027752604.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="38774409"/>
    <dbReference type="InParanoid" id="A0A401G5Q3"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
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            <end position="346"/>
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            <begin position="347"/>
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    </feature>
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        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
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            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
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            <begin position="835"/>
            <end position="858"/>
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        <location>
            <begin position="861"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1065" mass="115713" checksum="BFF028828EC147CE" modified="2019-05-08" version="1">MASNTTSHDTHDTQRPKADATAAAPDDPANSLSPDPSTYTKYRSLVISPNLHAALEYEERTRPGAYNNLGYSSGSPVAGGLPPPPRPKSRGKRAPSPPKSAASSAQNSPTVSLHSIGAGNADASSSNPYINPAPRLSFLLRENTLPVADPTSAPHEPLDDQHTNATTTRFRDDPPTSPRDPIPSPQTELRRASTDLQRPNSRHNRYFSSLARVEKIFGKGKNALGVSSDPNTRNERRMSDAGLPEAGDAQETGSKDTVMRPYRRILDRGAKLTTPSQHHYALSAPNSPTNGFQSQSVASPSSRVASPTAIAGQAMVPRPLFSHARQASDMSMGSLSPDSESTHNPPSTITHTRISISSTIYSSNSRSFDDSHYRAQGRSSMSADRESFIDFASPSFSSSSSDIPHENGPNKLVVFPFSAPESSASKFSPNIETSSSPAKPVLPRLTTTTTTTTATTTAITATPSAKPPLPTAPKPNFRRSRPTTLHISAADADRHFHGMPPTTNLLNPRERAELVRKTQKLTHLFGQTPGVALEMPGSDPVIDGCLPGNLSLNLTKRKHHKGTLSLSADTLLSGRNPASGQYTIPAVRGRPTLAHHEDNSTYSFSFPVNRSSEDSARPSRDVGHVIEIGSQKGDPSSDWDSHNGHGRPGRGVESPTSFIDLSDEEGAHDAISDHHPGQTPKIRRRRDRPLSPSSPSTPSLLSLSSEQQAEEERRRKRDKLAKLHRFLGSRVPAHLVLGTLDEGEPLPDPAPSPQGVMYEEIDTRKVRMPLRRRRSSSAAEFSATWSKDVERLKEDLNEREKAINVRRAVKMEKLFGVAPPQKLYHTRQPVLGPVSGASAVPGASGPPLSPSSPAFAAARGLSTSPRSSNINQSSYKPKWKKQARPGTAESSKPLITSEQDDILDPSQTLSDVYLHYRHSLNSLNDIIDRDDKQSLAELHDYLSGNQQDPLPQSPSSGMFTLVPPSAKADRRHSLPSRTSIISVASSEFSIATPTPEDSTFQARRRTAAKLTQFFGVNYRDLMNEILESIEKGLEDERGRGSLRPAEVQDLQQKLVNLKTKRDRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5U7</accession>
    <name>A0A401G5U7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone acetyltransferase type B subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0103990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608437.1">
        <property type="nucleotide sequence ID" value="XM_027752636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5U7"/>
    <dbReference type="FunCoup" id="A0A401G5U7">
        <property type="interactions" value="810"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5U7"/>
    <dbReference type="GeneID" id="38774441"/>
    <dbReference type="InParanoid" id="A0A401G5U7"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="235"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="279"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="323"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="468" mass="52034" checksum="273D9405429F3E71" modified="2019-05-08" version="1">MKPTMQEEVEDDLAAEEENKLINEEYKTWKKNAPYLYDVVITHALDWPSLTCQWFPDKESPSNKPYTVHRLLLGTHTSGQAQDYLQIATVQLPKRDDSSSADRLDRSNYDDERGELGGHTIPPQPRIQITQRINHQGEVNRARYMPQNPDLIATKAVSGEVLVFDRTKHSSEPERGGVCKPDIRLVGQHKEGFGLAWNPVKTGHILGASEDMTVCHWDVNSYAKTNSTLEPTNVFRGHASVVGDVDWHAKQENVFASVGDDRMLMIWDTRATSEPSTKIQAHDREILAVAFSPAVDHLCITGSADRTIILHDLRSPAKRLHTFESHLDEVLHVAWSPHNPTIFASASSDRRINVWDLSLIGVEQTPDDQEDGPPELLFVHGGHTSRPTDFCWAPGESEAWTAASTSEDNVVMIWQPTMHVWAGDEIKIEERELESEPMEGIESSSAVAEASGSGGAARSGSSNVDSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6E8</accession>
    <name>A0A401G6E8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0106110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608642.1">
        <property type="nucleotide sequence ID" value="XM_027752841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6E8"/>
    <dbReference type="STRING" id="139825.A0A401G6E8"/>
    <dbReference type="GeneID" id="38774646"/>
    <dbReference type="InParanoid" id="A0A401G6E8"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="548" mass="61420" checksum="EE93039BBF4D1B90" modified="2019-05-08" version="1">MEMHQDSTSEKRGHICPPSNATHPSDRWESLFVYGFICKFTQLRSKVEGLDSPMDFEEALLSNEPNPVMTQILSRFVLNLRPQTRNVSSDVISSTVVTVLQDYLKSSERTVFWDEELKTNVDPFHGMAQGFFAAHWDLKLKVLRQLVELQLSHSPAVKNIIDRAWGVVHNKHKKTETPAVPPPPGDPLSQEALQLIPLGQDTDRKRYWVIDDSPRLYLSTNPWKITATFQTIASTREEYMAIVDKVKESAPSEPKPGERRTKLELAHLALLKALQDRMEVIDAELTRLHRARRKIEQRNLLIAQAEVRETRTRRRTTRPDYAYMNDPISEDDQDEYTYQEQEDDEYEDQMEYDDLSGYRGDPSTSRRAAAGAGRRRSTRTSNGDGKRTADEWAEWRGERRSTRLGAPAETQLDNALPTRARTVDSTVSTNSAEGTPAQAPSGLKIKIHGAAAMKPTETAVEVVAGKKKSKYWYYAVEPVAAVASAPPPPSDYASTSYHDAGSSATNGSRYGGGSETSEVNGHDKNGDMELYEKSLEGSLSPASSMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6R9</accession>
    <name>A0A401G6R9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase 2C homolog 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0107480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608779.1">
        <property type="nucleotide sequence ID" value="XM_027752978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6R9"/>
    <dbReference type="FunCoup" id="A0A401G6R9">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6R9"/>
    <dbReference type="GeneID" id="38774783"/>
    <dbReference type="InParanoid" id="A0A401G6R9"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="52"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="412" mass="45842" checksum="A5DE7F9EE4BAF7DC" modified="2019-05-08" version="1">MAFRLWHSFQSPVLTKSRPRTFVQKNIARYHDYIRFSTPGGSARLLLNNPKIIGVASSRGERLTQEDFYSFVSLSLNPEELRLSLKKSFQIDWDPSALPDALARQVLFVGIYDGHGGSTVSGFLRQELHGLFENVDKSQIPELFAWAKELGGYFKRFKGGALAPWIRPSSPDASQELDLEARATLAFFEVDRMLAIENAAKECGATASVVLLQSLDNSATPFFASEKIALTVAHVGDTRVLLCSMDGGKFIPMTENHHADARVETARLRRMMVSSLIADSFGETRWMGALANTRSLGDMKFKPYGVTPEPEVRTHLVQGGEFSHITLLSDGVSSVVSDDEITDLARGALSPRHAAQRILAYAEEMGSEDNATVIVVPLAGWGKVSGEDKTRELREYRRRNMVGSERQKERWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6T3</accession>
    <name>A0A401G6T3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0107630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608794.1">
        <property type="nucleotide sequence ID" value="XM_027752993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6T3"/>
    <dbReference type="FunCoup" id="A0A401G6T3">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6T3"/>
    <dbReference type="GeneID" id="38774798"/>
    <dbReference type="InParanoid" id="A0A401G6T3"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="510" mass="57657" checksum="F4D06ABF4DB98017" modified="2019-05-08" version="1">MSQPMRPRFIPSRCDGTEVDGPLAFEGGDPHWLPLVWCPADFPIELFEVAVSQLIHHPEYNSTLILRSNMLSDTTADFPPSVPLLRDLIPTRNVCRKLLPRRPGRDAGLEQHCTLYTSAHGDPSPSTLVLTPLVEPGSSLPYYHPTVTHLAFRYILTDPPVLRIEVVPLPSTPTDVNSRIYRTCLALLETLHRYGWGAMTNYKKRVLHDCIIPREPYQDLYLVMRERHKHVVDTWHEVTDPSKHVFEDIGIATFLMLLWKDMYNTDESSRGSGQVAYESEPWRSWPRPLNGFLDLGCGNGLLVHILTAEGYLGHGIDLRARTSWSHYPDTTQSQLHVEALDPTIFADPAVSELPPYLRAGTFIIGNHADELTPWVPVLSTLCSASGYLSIPCCAWTFDARYERSSTPPYPVPDANFVENLNLGGDGSNKSSYSMYRIWLASLSLHCGWKVECETLRIPSTRNWAIIGRKTAYGSTEEADKVRQRVEQIVQFVCERGIFRTRRPEGRAGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G775</accession>
    <name>A0A401G775_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0108890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608920.1">
        <property type="nucleotide sequence ID" value="XM_027753119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G775"/>
    <dbReference type="FunCoup" id="A0A401G775">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G775"/>
    <dbReference type="GeneID" id="38774924"/>
    <dbReference type="InParanoid" id="A0A401G775"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="190" mass="22041" checksum="802BB825952D6ECC" modified="2019-05-08" version="1">MPDDYDKLTKEEREVRDKADRQREAAEQAGLPYTWKQELGEVDIVVPVPKGTRGRDLSVVIQKKKLSVGLKGKDKIMEGELCKDIKVEESTWMVEDQEAVYIHLEKVNKQQWWENVLTHHPKIDTTKIQPENSQLSDLDGETRGMVEKMMFDNQQKQMGKPTSDEIKKMETLKKFQEAHPELDFSNAKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7G4</accession>
    <name>A0A401G7G4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SGT1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0109750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609006.1">
        <property type="nucleotide sequence ID" value="XM_027753205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7G4"/>
    <dbReference type="STRING" id="139825.A0A401G7G4"/>
    <dbReference type="GeneID" id="38775010"/>
    <dbReference type="InParanoid" id="A0A401G7G4"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="88447" checksum="7C564C5DBF155C21" modified="2019-05-08" version="1">MRDYVESSLPGHIWHRDAFELKAVQDPDGEGCMLEGRMRVGDCVDDEWCVVWLLREISAKWDVAISVFDSDGEFLLIEAADSLPSWVTPSNAENRVWIYNSHLHIVPLSHVSAPSSKPRRSRYRGVKETEDDDNITEDETEDFIAVQDALKLVIDPLTDTLAPSQVETAVWSRIFGYPAAARQHVHVTKAYLPVDIAKALSANPSLVQKPVEAFYTRDALQLRAAHRMLRFPPQPSVLTTVKMTRTAYAQLVGQKFYPPKIFDRWQEKEGTTEWKWRDVGMKIACGFEMLYQESKGRSETSTISSDAVQLSMEVRKEALRRTPDYIVYIENLVSSGYFKGELQGSQLWNALEDKAAAAFIEVRRDDDSARLSFATAVNMAVSQASDTLIPQIQQKETSDDWLNVDAADLDAMLEENLGGKSKSEPEVLADAMDVDVEAAEDHVAKEQASRLQDLAKKVEEFVEGEGDVEGARFADEEFSEEEFSDETEEESDEEMRPADDEVDKVDKAARRAAMDRLVPGLDPSEYGQMPPSFHSNSQRVAPTTIETETRNASSEGPSESPTEPRTRPIRPPILPRDNFEGVDSDDETDEENGGDDEEEEDMPQVVGDVEIDMEKEQDEFLEFARQTLGVSDEQWGDIVRERKGRGVFVPGYVASESKLPQQTVPASSINVAPAASTQSPANPNLDSFEAVMQAMDAQLGLSQTSRKGESAAAASGNSGKASADIDIETAMDAELRTALEKEHDDDGDEAEIEQGMDYNLIKNFLESFRSQAGLSGPVSNLAGRLQAGWTFPRDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G884</accession>
    <name>A0A401G884_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0112570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609285.1">
        <property type="nucleotide sequence ID" value="XM_027753484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G884"/>
    <dbReference type="STRING" id="139825.A0A401G884"/>
    <dbReference type="GeneID" id="38775289"/>
    <dbReference type="InParanoid" id="A0A401G884"/>
    <dbReference type="OrthoDB" id="3239894at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="808" mass="91087" checksum="3208431AB17F423E" modified="2019-05-08" version="1">MPLPSKSKREDKRYEYQKQKVPCWCEGCKGKHVPQYTQHDHQTRPRYNSEKQSDDERGSVKLGATGILKKLAKKLKLSPKKNSTGLSTASPPSPSQTPQPDSRPYSVGEAEGVQSHYQCSLPSPMPVDFSNDPSYAPKLCQSDSANILLAVEPEDSILEHSGEVLPYHGEPALDLQVSHSAPVADDTSSGSARASQESVLSYATHCTAISPAPDLGVQFDVDVNDPDAHNLLGPNLALDANVQPAMEPCLEMQVHQNADRIHEDVQDMPHNVRYVPHEVHEVPRDMPPNSIDIFTDAAEHWFWRVLLLLCSWLHLHYHVPYCTCALILQVMQLIFVAVGLLSTQADAPTTLLTAIKRLHLGDNFEIKAMCPSCRRIFPSSPSLTLRCSSCNIPLFKRVAVRARLVLPLEAFQADDAADTQAQVPLLQTPFSLLSEQLPAYVNRLEGSLDPWRVHPQTPPGQLWSMQDGKLWQTLLGPDGQMFFYNGQDRTNPDELRIGITLHFDGFGYQRSQFSGKHSTGVLSNCFANLEVQDKYQSRNLVLCGITPGPKELSADELQHFMKAYVDDLLKLYDDRTVIKMKLQPEGRRVHVLLLAVCCDHPALCRIVGFGDHNTKEGFCSRCKIKHADLETEAGMTIGAFPARDGEEHRQHAQEYLQEMDPQRRAEFFMQHATRYYELSHLPYFDAVRMTVVDPMHNILLGVVKTQWLDAWINTKALRERTAVNKVCRELDQVHEYLKIFEMPQWVARLPNNVGYAAGGSLTADEWKGMALNYCPIIVPLIWDKWQPSAEATYEKRMKKWKADNITHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8H3</accession>
    <name>A0A401G8H3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Las1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0113460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609370.1">
        <property type="nucleotide sequence ID" value="XM_027753569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8H3"/>
    <dbReference type="FunCoup" id="A0A401G8H3">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8H3"/>
    <dbReference type="GeneID" id="38775374"/>
    <dbReference type="InParanoid" id="A0A401G8H3"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="503" mass="54552" checksum="699CB6DF692AA053" modified="2019-05-08" version="1">MRLPRRVPWESLSELDQVCSLIYADENDIDAKVQAVNRISAWRAITSLPHALESTLALLCAILDDSRRQGLPSLLSLRQSYATALIRLVNGLVDPLQVGAYARSIASIAAQLGLPAWLVELRHAATHEDLPSIDVLREAAREAMRWLLDNYFLPTLNPSAAAPSPKTVLRPLSPLLKQYKTLLKGTTRDASLLPTRKHEIAKVTRDIERWVAEAKVAANVSVDAIEWDIGAQDDSMEDGRERWALERLCDALLELGALVPVSKKKRTISGVPLAPAPANLAIWTPLLTNLQSLHPKLPAVLAVRIVSHLLSRSGPSQADVGADTVSLLPQDDAQMDTSYDRCLAGWANWLVDTCGAGAEEEEQEMLRRDDIVVSLITGLGPQREASKTDIMVAQDLLTALCAGHPHLERVAASLPPIADAPSNQWNSTDIDLMQQRLSAVLALARAPDAPSSSATGALGAQPPNITNPMEPVCTGLPPGWRLLSEKDGWRPSPIGVHVPRVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9P9</accession>
    <name>A0A401G9P9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609801.1">
        <property type="nucleotide sequence ID" value="XM_027754000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9P9"/>
    <dbReference type="GeneID" id="38775805"/>
    <dbReference type="InParanoid" id="A0A401G9P9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="88" mass="9482" checksum="D508608749FAC839" modified="2019-05-08" version="1">MPTSAIDDLVHNILAEVASTIMSIPASPTLVNGIPSRTQTPFIHASSPSPSIELSHASDEQEFATRLISAIHIPVNFINILVALWNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Q7</accession>
    <name>A0A401G9Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609792.1">
        <property type="nucleotide sequence ID" value="XM_027753991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Q7"/>
    <dbReference type="GeneID" id="38775796"/>
    <dbReference type="InParanoid" id="A0A401G9Q7"/>
    <dbReference type="OrthoDB" id="3262734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="127" mass="14414" checksum="2D98277DD70FFF96" modified="2019-05-08" version="1">MIFVIGGYFLTHEQLSTFGARRGLDIPNGEAYILNSHLLSRGIRSCTAVPVALPQKDSAEPIVVGTLITTHQREDRAERFRDCIRFVENDDDLKIKRWLQRHGVSEPVFETVPDPFGKFNEDGVMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9V3</accession>
    <name>A0A401G9V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspyridones efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0201630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609879.1">
        <property type="nucleotide sequence ID" value="XM_027754078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9V3"/>
    <dbReference type="GeneID" id="38775883"/>
    <dbReference type="InParanoid" id="A0A401G9V3"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="250"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="439" mass="46818" checksum="552CD3BF9BBD6C5A" modified="2019-05-08" version="1">MQSDTSPSHSSEIIALSSPRSAVHGAPTKVEDKPVNPPPITFPDGGIRAWSNIAGCFLLSFTSYGQLNAFGVFQTYYSQTLLHGHSVSTIAWIGSTQLTISYVAGCILGRMFDIYGSRVLLVSGCLLSTFSLMMTSLATKYYQILLAQGFGLGIGIALQFYPILAVPSHWFCANRAAAIGIVIAGSSLSGIIYPIMLSRLFVSVGFPWAVRIVAFMNFGCQVLAIPFVKERFPPRLGIPLVDWQAFRETTFLLHALGGFFVAFALYTPYWYIELFSLQKGVGANLSFYMIAIMNAAGLVGRVVTGYAADKYGRFNTLAPVTLLGGISVLAIWATSWHTAEIVVFVLIFGFTSASYSSLASTATAQVTSDPSRIGARTGMFMTAMSPGILTGPSIAGAIVDASNGGYLGLQIFVGVFLVAGAALALAARWNGARSLVAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9V6</accession>
    <name>A0A401G9V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0201470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609863.1">
        <property type="nucleotide sequence ID" value="XM_027754062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9V6"/>
    <dbReference type="STRING" id="139825.A0A401G9V6"/>
    <dbReference type="GeneID" id="38775867"/>
    <dbReference type="InParanoid" id="A0A401G9V6"/>
    <dbReference type="OrthoDB" id="3226657at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="64"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="613" mass="68346" checksum="1CDDD75E4975B492" modified="2019-05-08" version="1">MATPSLKTRTLCEVPLKWTGPNEQPLDILSEATPRRFRLIDCVQLTQNKLLRIVEFPDYCSVRYAAISYVWRGNAIDPTYTSRVTTFGVVGAEDADPISVEVLNHTCITALHNHADYLWLDRLCIMQTSRDDKVWQIEHMYEYYKSCGVCIVLPGGLQRIVRLDEETAWIHRGWTLQETLAPEHVVVLFAWKGGPGHIVSLSAEGAITEVIPSQSAISAIANIVNGCAQGYAIFIPRRKPRLYKILRFQIRIFGKNLPNLLSLSAAMDKLRKQDWSRDMIEHAIWKCAMMRTSSRPVDMIFSIMGLFGVVLDTRTFGKNDRLGATIALTKEILRKGGSASWLGASIHLPPHRSLSTFPVFPQTSVSGKALVRTEDGLQEAAMFMNAECPTICMPNGSMDDDGYFTFSGASVPVGRKQQQLPLESVNPSLPQVTNLETVDGTVWVVCNSRESETSASDSRTFAVVLGQFGQYRPPVYATQTLKHHTSLRLMLIEEHGPGKFHLVDFCTSEGSSDDLPWKTRPFSVGGPLTLTQDMDQIVLCNRLSPSRMNRWVGTERLRIAEAEEALSQAALERLLAVAYLQRNNTSGRAESSEGDVDSDTDDDGNLRMSDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA47</accession>
    <name>A0A401GA47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0202160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609932.1">
        <property type="nucleotide sequence ID" value="XM_027754131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA47"/>
    <dbReference type="GeneID" id="38775936"/>
    <dbReference type="InParanoid" id="A0A401GA47"/>
    <dbReference type="OrthoDB" id="2803839at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="372" mass="40988" checksum="DF098D87481FC461" modified="2019-05-08" version="1">MAQPTSAANSPTNGATTPDVSSTAALAASMFALSSSVSPPLSPIKSTLGKRTRLMHSQDEEDLNDDVDELPVASDNETTDATRNVMRPPVAPSQPVQHILTSNTLTATLGGQSLKQLAKKLVKKTKLGQDQLTEVDVFTSSVLNAEQNLHLFIKLEEVQREVSELRKSQAEYRVSESLSKNIQKISTAVLLSVNLAGYMDAAAVGPVQERLKCDRFDMPDNIEHNPADWGKVKTVIQYHQTQLRSAWKKGIGESVTHEDPKEHTDIFTLTTTIANGNCTVTIGLCARVALMASRDIFCQRAYSEKTYWRKVNERVAFIRQTANEDQKAVNRAMRHILKNDRNQHGQCSEKIKVTEQPNNSFQASIDSCVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA90</accession>
    <name>A0A401GA90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0202910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610007.1">
        <property type="nucleotide sequence ID" value="XM_027754206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA90"/>
    <dbReference type="STRING" id="139825.A0A401GA90"/>
    <dbReference type="GeneID" id="38776011"/>
    <dbReference type="InParanoid" id="A0A401GA90"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="368"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="486" mass="55310" checksum="225D84090BE7FC81" modified="2019-05-08" version="1">MDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLKNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGDLHPCAYISQTLNPAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSRRNGLDDSESDNEDRILLPNALFVRSISPTLFDEIRNHAAKDLIVHEALEAVAHKGPFPMKSSLSDWEVHDGVILYKGKIYVPPSETLRRDLVRLHHDSPAMGHPGKFNTLELLRHEFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLLVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDRETERVNQELEIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAF2</accession>
    <name>A0A401GAF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0203470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610063.1">
        <property type="nucleotide sequence ID" value="XM_027754262.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38776067"/>
    <dbReference type="InParanoid" id="A0A401GAF2"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="1565"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1363"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2067"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="952"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1850"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1375"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1424"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1465"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1509"/>
            <end position="1530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2102" mass="232375" checksum="576B2E7357840CD0" modified="2019-05-08" version="1">MSGEEQAASVSATIEKSGTLEPANSHVPNALAGVSRLSQSDEDAAARDGDEKALEWHEVIELQAFSERKVWIEEKIKFLESLPPIEVFVGLDAVRSSAEEVPGLPSRSQLQEWLQEHDRIEKETEIFDSGELRKLKKFTKAATQRNLSLADTDLIELTLTTIYELDKLLHLLRDRSDNLELLNIRLTWEERRIASWVELRKVVADLRDFLGSRARWSPSVYDVAVADDELVGGHQRKRSGSFVSITSTTSESSYMNAPGLARSSRFRLAETLTRDAAQFASRASSLRHTKIAGAGKTLDKLIDHSRKPVPEELLDEQDQLENQGINEMEDIGKFVMGVVMQWKKADEIYVETMKDKTAALTLLEEIEVANMHHPTARQDAAFLSRSTALMKRLTMRGNPSLLSSVFPRPTHHLYPDQSAANESVVRLLSSELSSAIDEAKKVEACAKEYHASYEAVKRVETACKAASDLSLTLVSLIERLQTGIATANGDGTPPDLSTEACLDASRHSVFLAMLPATVEELRKADKDASNLLPGARAALLHLDRPGIDDGFKSTSASEIEGFAAHRTAASRASEEAVGHASILHDVRQVWFAMEHLFQDLESIRDEIPDAIERQMWRQQMSSHGAPPTPETPTTELAPTTISPASIFARLDTLQVRMNQEVSSPCRAVIFSVGPALKDYLSECSTNLDSFLSRTTELARFWESVLNQAAIMGNVRDEVHSLQIQMEDLKVRFDKGIQDVLAGDLVSDALLLTEGGLTSEVKRSQDTLQAFLADLPHRVPFTGGLEMSSVTSSKRTSLSGSFSLDIVRQAAPLYLPFDPAILDHAVRADSNAYSMMLSGVLKVLEQKTDHFQLAKTAKTIDLATETIVNSIRHAVKSAKVIRQSVAKFPDNIHLLDHLALLSEEVNRLLQTDGLEIPRSFSPVRDLLHRLKSVSGDAGANVRDSLLISRQRALEEAEVQYNSWKDRVSSLQQQIAKALDAERSRLAEEARLQEEPGRLEVEERAKLEQLLSEAEERARREREQLEVEERARREQEEAERLAKAEEERLGKEQVVAEEREKAEQQRLWEEQEAERVQLEAGEKQRLERVTAAGREVGERRRLEAQELEAKATPGTDTEVSGLQEPALREKHQRAVTPLEVVKESDMEDSITHGVPSLHVQEDVFGIQLFPSAVIHRPPQKRSDLQTRIYHLRKRLCSIHINDVARPALRSGDSLPGDELRQRMANQFSAVIVEVDHLPPSLPDNTAADTDLRSLRSEVSASTKLMQKVHRLADLTMAVGSCDSALSDLLEHVDSYPSPPLGPLSSSYTTNTALTPEKQMSDRLSFTKDVLEKMQACYSAVPDDSRATVERDRVLQTWSELQAMGLDRVSGQKSRPPSVISTGRSSRSSGKSNSGHQSKKSTGYSKLSVGSTGGFLAPLPQPHPRRSSAGASAVGHSRSASRASATSSIRSVSSPISPSSTLYGSTFSSRQRTASISSASSMTTPAKRVQAAARPRAQIIQADRTASPALTEISSRSTSRPRFNSSLSSTPHSTWARVPRQSLSAAAKVTSPPAVRAPPGVKKPYVADPKNKLDVAVGDVVNKLSANINVEVVADTWKDQSGKYWIGDQEPKLCFCRILRSQTVMVRVGGGWSELSKFIKDHFADAFRILPESPPRPPRASVGSRDEKWVNSATFSQAVDNMFPYQPPGTPLPNLSFIPSFALVSPYRTAVLQKSRQRFSVFARRVSITVVTFYDVFDVLGAEYPGKFSTICLAAMIKSKSVRCFRVDCDIALHSIFECANELFNASRLCPACETSLTEPDDVVVCSLHPSNDYKTSVLSGLNPATILEICSRAMSFWQYQVHQEFTFQHAVLRNVNEKTALLQKQLDNVIREANGEISLLNNKVSELERDLELERRQAANVQDTLREREKEYQKLKTQYDKMKRKALLAPGGVTGEGAMPFGGTHAGERQVLEEQSNKHRGMAFGAAVGGTVDVGAVVGDMEANGIQRTPIVNRTVRPTGVQQGTAWRQPNAGQTRHNLQRQPFNAMVDRSFRTSSAAQSDRSGSAAEVENMLGQGQPQYVRTSTTWSLPQVHNNRPPQRVFAQPSMNPRKPSNGKFRPAGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAI1</accession>
    <name>A0A401GAI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized bolA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0203710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610087.1">
        <property type="nucleotide sequence ID" value="XM_027754286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAI1"/>
    <dbReference type="FunCoup" id="A0A401GAI1">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAI1"/>
    <dbReference type="GeneID" id="38776091"/>
    <dbReference type="InParanoid" id="A0A401GAI1"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11550" checksum="9742E3E962BEE64B" modified="2019-05-08" version="1">MISLYRRIAGCRLPPHVRSYIPTPAELSEGEKAIWNKLNEKFSPSELKVMDVSGGCGSFYNIIIASENFKGIPTVKQHRMVNEILKQEIEGIHGLQLKTIVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAJ6</accession>
    <name>A0A401GAJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0203910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610107.1">
        <property type="nucleotide sequence ID" value="XM_027754306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAJ6"/>
    <dbReference type="FunCoup" id="A0A401GAJ6">
        <property type="interactions" value="823"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAJ6"/>
    <dbReference type="GeneID" id="38776111"/>
    <dbReference type="InParanoid" id="A0A401GAJ6"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="284"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="465"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="580" mass="63560" checksum="3DD7954032EE4AC5" modified="2019-05-08" version="1">MLVLYETSLGYCLFKVTDTAKIESADLWEEFETPEKANRLLKLKALHRFTSTAIAVEEISALQNGKLGKGLKQFLSDEIVGKGKGKQSLAVVDKSLAHSIGKKLGIKVIADEQRMDLFRGIRSQLTALMDGLDPKDLATMSLGLSHSLSRFKLKFSPDKVDTMVVQAIALLDDLDKEINIYAMRVKEWYGWHFPEMAKIIVDNLAYAKVVKLMGFRTNAASTDFAAILPEDLEATVKAAAEISMGTEISDSDIAHIHSLCDQVISITAYRTQLAEYLRNRMNAIAPNLTALVGELVGARLISHAGSLLNLAKQPASTVQILGAEKALFRALKTKHDTPKYGLIYHASLIGQAPPKLKGKMARMVATKAALSIRVDALTDADGKSEPMAPSIGIENRAKLEARLRNLELQGDSAGIRSVSNGRTQSRFQMTGETKTYNTAADAVDMVPTQREPVLAAAQAVLDVDAEKKRAKEERRAKKKAAKEAKERQEQEAGEALESGHAAPTDVDGEVEESREGKKEKKRKRRESAVDGKNGEDKETDETDTERKARKKARKAEKAAAAAAAEQVNGEPTKKKRRKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB50</accession>
    <name>A0A401GB50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0205920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610307.1">
        <property type="nucleotide sequence ID" value="XM_027754506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB50"/>
    <dbReference type="STRING" id="139825.A0A401GB50"/>
    <dbReference type="GeneID" id="38776311"/>
    <dbReference type="InParanoid" id="A0A401GB50"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="13">
        <location>
            <begin position="230"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="10">
        <location>
            <begin position="230"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="542"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE79394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="666" mass="71090" checksum="3C982C539115EE31" modified="2019-05-08" version="1">MTTNLTDYLQDSLVGEPAPQKISAYYSLVFPTFTYYLQTLNVTIGRRCIPCSSASSSDNPQVDVDLGPLKSVSRLHAKIEYEEEEERFVLVVIGRNGAWVDGVWSGSGSKVPLGERSQIQIASRTFHFVLPPPPAPEDSPSPSSQSSVENRPRSPSVDIVDVTSISPPSSLPSCSPPPAVVLPAPPKIPPRAGTQLPNSNTIRHKSNTKKRKKSDPQNSLPLPPEVIPPKPQLTYAQLCYRAIKALGGKGSLQDICHWIKETYEWYKYCGKDWESSVRHNLSSNPGFKKLLRSKDEKGKGALWVIDEAFEHTFEELDAKRQAAAALAASGGVDGKAIGKRGRVVIPLEPPFKRSVKGDLKGMPLPPPLTSTPLTLKTNSHSPANTAPPSTSDTPPITLASSDSTVKLETPALHIPASRGLSSSSTASIVTPSPGLNNATAVTPEESASTRPSATPFPAIPASVRIPIIIGPVPPSSPPQSSDPASSTPKPIVLHDNTLILNPEIFSHLTPEHLKDLEGLGAQKALEILQSYIVRYYKEKLKAEGGRGRGRGRPRRGRGAAGGRGSTSAGAHPRTDAPTAGPFAPAPLLPPAVEPLPMTAMAHETPAHPNSDVAFIRTTPTSDVLWQAVDAAPSPIVVIDDDPAEEEGPAMKRRRLENGMSVSTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBZ1</accession>
    <name>A0A401GBZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0208940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610607.1">
        <property type="nucleotide sequence ID" value="XM_027754806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBZ1"/>
    <dbReference type="STRING" id="139825.A0A401GBZ1"/>
    <dbReference type="GeneID" id="38776611"/>
    <dbReference type="InParanoid" id="A0A401GBZ1"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="225"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="463" mass="50214" checksum="5CFE43F210735DE5" modified="2019-05-08" version="1">MACLAAPPLTRSRASSTNVRPPLTLSTLGARRRSNSLLDLPPPTPSPLLSPCNSPHNSPLEPNASPRLVPLSIPSSKPDSLTSFISKVLQLFGHSPMHSVPSTPSSPRHSRASTDDTILPMSASPTRSTFVQSFPEKNVVTWVWPTSPSQYTPVLLVLVLFPLSTALVVSSMYTLPITTFWPGTLQDIAQLGRELSGFSQSGPASMAHVVAVISVLTMWNHAWSIPGSVLWNVLAGALFSPIYATLLFTLLTSVGSVFATLLAAPLAPFLEHLFPRALDFTRIALEGDSPGSSTKAKSSAWVRLSVLRLIGIVPWSGINITCGVCRVAIRECFLGSLIGSLPWTAVTCQIGDILQTVASNPSPSKQTVQSLLTSPEVLFKLAFLTILSLAPILGRNRLREWLSPAAALLDQEMSSAAEERVSRWVWIKEWQGRIRLPSRSRAQEAFRKELEVLTQEKNQSLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC36</accession>
    <name>A0A401GC36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar import and degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0209230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610635.1">
        <property type="nucleotide sequence ID" value="XM_027754834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC36"/>
    <dbReference type="FunCoup" id="A0A401GC36">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="GeneID" id="38776639"/>
    <dbReference type="InParanoid" id="A0A401GC36"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040979">
        <property type="entry name" value="Vid27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040768">
        <property type="entry name" value="Vid27_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17748">
        <property type="entry name" value="VID27_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17747">
        <property type="entry name" value="VID27_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vid27 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Vid27 PH-like" evidence="3">
        <location>
            <begin position="232"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="410"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="773" mass="86880" checksum="34F226CDD6D6D690" modified="2019-05-08" version="1">MNIFRSLLGKVWHDPNAAEVVKISEGQLYLVRSGTIRGARECIYNDAMATIRRVPSLEHNFQLVITRVFEDGDQELLEDEEETDEERVFLISEELGFRTGVTEDGPTFMWRDLDGDVDEFYEFVASGTNEPTRAFFETCMYRAMYERKYKINADDIGDVQLQEFISQTSTTRDSKASSKTHVSSSSKRKEASEAAHDPHFPASASTGAAAITKSGKAKNWKNVAADPALPALVAEEAELHLWNRERGFFVIQAEVVARVVRNAASGPFDYWLNAFGEDGQLLAHKITSDMNQRWSSKVLSLTWNHTSDTGLQSSWCLRFETQKAFSNFQRIFTQALWEGLNQYSWEKAKLDEQAYVMSSNTEDVEMRDVEDEEDEEDAVEDELDKSEDEEEPEEYADAEEEELPALGNGERNSQLTVGYKGDRSYVVRGNSIGVFGYTGDNQVKYHATLSKLATPKGKTFKPKHVMLHDQDSKMILINPSEPNSLFSMDIERGKIVEEWKVHDAVQVDHIAPDSKFAQMTPEQTIVGVSHNALFRIDPRMSGNKMVDSQFKQYVSKNQFSGVTTTESGKLAVASQKGDIRLFDAIGKNAKTALPPLGDPILGIDVTANGRWIVATTKTYLLLIDTLIGEGRYTGSLGFDRSFPANAKPIPRRLQLRAEHVAYMENSVSFTPARFNMGEGQEENAIVTSTGPYVVAWDFAKVKKGLLDKYEIKKYEDFVVQDNFKFGDDKEIIVALQNNVLAVNKKSLKRPTRASLATPMKSLQGRSNIVNTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCH3</accession>
    <name>A0A401GCH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Succinate-semialdehyde dehydrogenase [NADP(+)]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0210240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610736.1">
        <property type="nucleotide sequence ID" value="XM_027754935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCH3"/>
    <dbReference type="FunCoup" id="A0A401GCH3">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCH3"/>
    <dbReference type="GeneID" id="38776740"/>
    <dbReference type="InParanoid" id="A0A401GCH3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF10">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE (NADP+)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="323" mass="34085" checksum="5A858C52725BCE08" modified="2019-05-08" version="1">MITRKLAAALAAGCTAVIKPPPETPFSCLALVELANRAGVPPGVINVVTTQANVNDVGREMCENVAVKKVSFTGSTNVARLLYRMAASTIKKVSIEAGGNAPFIVFDDADVNAAVEGAIVCKFRGSGQTCVCANRIYVQSSIYADFASRLAEKVAAFKVGNGLESDTTHGPLIHERALEKVKRHVDDAIERGAQLVMGGSRVPGKGTFFAPTVLSDVPADALVNTEETFGPLAALTRFETEDEVIRLANNTSVGLAGYFYSRDVGRVWRVAEALEVGMVGTNTGLISQAVIPFGGVKESGLGREGSHGIEEYMNTKFIAFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCR3</accession>
    <name>A0A401GCR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610889.1">
        <property type="nucleotide sequence ID" value="XM_027755088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCR3"/>
    <dbReference type="STRING" id="139825.A0A401GCR3"/>
    <dbReference type="GeneID" id="38776893"/>
    <dbReference type="InParanoid" id="A0A401GCR3"/>
    <dbReference type="OrthoDB" id="2446696at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF39">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="1">
        <location>
            <begin position="69"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="183" mass="20290" checksum="D8872827C929AA8F" modified="2019-05-08" version="1">MIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIDKPLTNLMRTAAGSPPFEWTTECQMTFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATSAVLRQADINGDLHPCAYISQMLNSAERKSTTANSLESFEPSLNGAIILKALPIPSKFAVITRTSHTSVQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCW0</accession>
    <name>A0A401GCW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0212040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610915.1">
        <property type="nucleotide sequence ID" value="XM_027755114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCW0"/>
    <dbReference type="STRING" id="139825.A0A401GCW0"/>
    <dbReference type="GeneID" id="38776919"/>
    <dbReference type="InParanoid" id="A0A401GCW0"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019068782" description="Long chronological lifespan protein 2" evidence="4">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="119" mass="13000" checksum="D98C645A2D43A472" modified="2019-05-08" version="1">MLPRIFALVLALTLMSSVRAQFGFFEQMFGQHQQQQQQQQQRPPDGVPQWVLQSDAVPCAQYLCPDTLFCAPGPAACPCPDVQDVRCVVPDAAEGGTVVCVRGRVDCAEVTRLARPLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCY9</accession>
    <name>A0A401GCY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610896.1">
        <property type="nucleotide sequence ID" value="XM_027755095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCY9"/>
    <dbReference type="STRING" id="139825.A0A401GCY9"/>
    <dbReference type="GeneID" id="38776900"/>
    <dbReference type="InParanoid" id="A0A401GCY9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="952" mass="101667" checksum="D0B480CD772CCD90" modified="2019-05-08" version="1">MPLDIDPNYVLQAAQLTAIVAAAPRQDDPCYPDWETRIYLEVSRLEKSFPQPLKSLRMPGIVISALLEFTQTYQQKVLARLDHISNDDERIYKRYPPAVREYGECEDLGRQWWTEDPYCKLPPVKSTPAEGWGNVPADDDTQGRGEEDLATGDLITKGKGKERADNDVGTGMVGERIVHVEAGEDKGKGKSKEKAQGKAVHAMSEEEDGGEGEGEGEEQEGEDDDDADSDEDDDADKDDDDEMAEDVPGAGQPESIEVDAASPPPPTARPISISPAAPSLRKRKAVITESSEESENEEAAPKAKRMKPIEVAKEKGEAPTTSGRAQRAQKRMAQTEVEGSKVSTKKSGKRKAKESSDEEEVPTIKPPKKKCATKEYKSKEFIESEDETPAPPSNLPAKIAGDSNDGVAKTNAPAKPVKQTTRMTVTPHVAPKAKAKGKAKATAKGKATVKAKAKVTVLQKDMWKKMSTRVSDFMWAHATDSLVPCVGCQEKEWPCKLNTANFGRCLECAARGVSCSIAPRNTDSVSLRGNSHTAQREFQEMCAALVVEGKPLPTSPPPYNVKVDSDEPDSAEPMVMGASKRKPPKKTKMRNAAASSSKVKGGEEVEATKQKATVMPYEANAEGEASVEKSSKSKCATKSTTATGAVALSNSGEVSKSGAPAKSGAVAKPGEGKKSGPKAKPVRSQNSGAQDGGEVTRTSVREPDEVPPAKSVAKEGGQTTRVVMGGRSGPMVPVITRKAKVSAPKAAAKMPLVEGDGMEEAARLAMEAVRAMAFQTGPAAPPQASSSKRMLTPVADEPEDAPEYQAEVAEDERASLERPHDDRWRSLLMPHEMSAGAAEVAQEVTPSLEISKASKGAKSSTLAKAGHLNEGRRPAKRGAPLDRKAAKKEAEAKRDAKANRLRAVPPTSKAPHLRDIQRVSTGSPAPVNEGDTPSGEETSQSSNDDCANCAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD53</accession>
    <name>A0A401GD53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0212950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611005.1">
        <property type="nucleotide sequence ID" value="XM_027755204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD53"/>
    <dbReference type="STRING" id="139825.A0A401GD53"/>
    <dbReference type="GeneID" id="38777009"/>
    <dbReference type="InParanoid" id="A0A401GD53"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="236" mass="25528" checksum="B2AC3A3AF63C739E" modified="2019-05-08" version="1">MPGIVISALLEFTRAYQQKALAWLDHISNDDERIYKRYPLAVREYGECEDLGRQWWTEDPYCKLPPVKSMPAEGWGNVPADDNTQGRGEEDLATGDLVTKGKGKERADNDVGTGMVGERIVHVEVGEDKGKGKSKEKAQGKAAHAMSEEEDGGEGEGEGEGEEQEGEDNDDADSDEDDDADKDDDDEMAEDVPGAGQPESIEVDAASPPSANCQTNIDLASCPITPKAQGGHHRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDR2</accession>
    <name>A0A401GDR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0214820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611178.1">
        <property type="nucleotide sequence ID" value="XM_027755377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDR2"/>
    <dbReference type="STRING" id="139825.A0A401GDR2"/>
    <dbReference type="GeneID" id="38777182"/>
    <dbReference type="InParanoid" id="A0A401GDR2"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9460" checksum="9847BB38F75D1EDF" modified="2019-05-08" version="1">MYLGFGRLPKHVTFTTTDPELLPVPSPDYLALHAACAKVAHLSGAAKYIDKVLEDLEEMPVLSEDGSSARLLEDALLHASSRSPVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEI9</accession>
    <name>A0A401GEI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0303130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611511.1">
        <property type="nucleotide sequence ID" value="XM_027755710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEI9"/>
    <dbReference type="GeneID" id="38777515"/>
    <dbReference type="InParanoid" id="A0A401GEI9"/>
    <dbReference type="OrthoDB" id="3270497at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="687" mass="72477" checksum="4C99777F08921455" modified="2019-05-08" version="1">MAGTITPFPLDDSPSARPSSPRRSLSLQPVLRLFDREDSLGMQPRTARPASVSARPSTSPSEPKPFLTLKLSSPSFLDTVIKDDGTKEPLYIVQTAGELTSVHRLDKVRRVATRAAAVQWPPNIIDVAKTKGKGRSGKSIQLAGSWRDAEDFLRLGPLGNLTSRKFTIPQCPHSLKWKFFPGNSYFCTTSGVKGPVAVLDPSVKGSAPRLHIYQTLLPASAPTGAGGVPLVVVDHLVLTALLLSTSTQEWLDRQPGAPLPGESHPIVQRWLEIIRSPPGPASPSSSALSSGSGSGSTRSSSGMSPGVGSTPTLGTLAEAEREEQTSPVVPFPLSPSEMGSSSGSGSNSNSNSNHSNTHAHSKSRSSFERVLPETPLPQYDFSLAPYDLPPPLPPPPPPSPPSGATSRFVIANPSRPCSPLSDGRSPSPPTPYYSFADPYYASSSSKHPYSSWSPQSYSSAPSSVSSPTSPGPRRLPTPPVPAVASAYPFPPSVSGLVPRAGATSPTPTLSRVLLHSQLPPPAPPPPQDLPLPPKLPPPPSSLPGSSMHPHPLPRIPIDTPLPYAAHPRTFSLPPMPSYPPPARPDGSASPSPEKRGARSRSRPLPDPNDLALRAMAISDGASVPGHLQAITNGPHVDAGRVRVPYGVPAAYSPESAEVRDGEAAEDHLPPPAYDAIDFGRRTGMRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEU3</accession>
    <name>A0A401GEU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosylation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0304150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611609.1">
        <property type="nucleotide sequence ID" value="XM_027755808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEU3"/>
    <dbReference type="FunCoup" id="A0A401GEU3">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEU3"/>
    <dbReference type="GeneID" id="38777613"/>
    <dbReference type="InParanoid" id="A0A401GEU3"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000286">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20753" checksum="B8C0DF157BF56A11" modified="2019-05-08" version="1">MGANLSKALAKIFGNREMRLLMLGLDAAGKTTILYKLKLNQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLVFVVDSQDRERIDEAKQELHRILSDREMKECLLLVFANKQDLPGAMSPAEVTEKLGLHRMRDRSWYVHPSCATTGEGLFEGLQWLSQNVKKRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEV5</accession>
    <name>A0A401GEV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0304260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611620.1">
        <property type="nucleotide sequence ID" value="XM_027755819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEV5"/>
    <dbReference type="GeneID" id="38777624"/>
    <dbReference type="InParanoid" id="A0A401GEV5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="186" mass="20927" checksum="D7198A9C5A5066D5" modified="2019-05-08" version="1">MDLRSRLLLHSLLYPSFLTTTRRALPHWDWHFRSVSYSSIRKSGVWTARTHHENSACREVWDFISAAALSSWCRLCPWKYHIPGCEGVNIGSTPNFSCEGDSRCELLIHVHMGIQAIVVSTVMLLFSPALAETLDLCPLFELSCSSLHLFDTCRCEVDPSTSWHCIVLLGGARPLTPAQLSHACTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEZ1</accession>
    <name>A0A401GEZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0303920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611586.1">
        <property type="nucleotide sequence ID" value="XM_027755785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEZ1"/>
    <dbReference type="FunCoup" id="A0A401GEZ1">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEZ1"/>
    <dbReference type="GeneID" id="38777590"/>
    <dbReference type="InParanoid" id="A0A401GEZ1"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="163"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="436"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="733"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="754"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE80673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="827" mass="90587" checksum="23F9CFCCE73A431A" modified="2019-05-08" version="1">MDDGLVLNLAVDDASTSKVTSAKKGGRWTDRLKAKRVAKRKTRSEESEHTQEPDHDVERRPSKKLREEHPTPSTNVDHTEERSARPVQIISSLFTSNPKVEQPTPSAHPLKSASRPSNAPLTDLSTFSGLGLDPLMVAHLSSKMDISKPTSIQRAALPHLLTASENTSSRDVFIQSETGSGKTLSFLLPIIQDLLPFSSLSYIDRSIGTLAVIIAPTRELAKQISDVLEALLQLRLRPQDETADASDASPRLTRWLVSGLLTGGSTRTHEKARLRKGVPILVSTPGRLLDHLQNTESFDVGKCRWLVLDEADRLMELGFEETIQGILRGLDGRRKLAMQAADEGKSTEVGGWDWETRRRTVLCSATMREDVQKLAGTTLKDPIMIRATQDDTPRPRDGALRDDDVSGLATNSQKFTPPSQLSQKYVVVPLKLRMVTLVALLRSLLSQAQSQRGAKIIVFLSCTDSVDFHWHLLGGTSMGDGEDGSDDSDGEQSGIEKQDPSPRKNGIDISPEKIHFKSPLLPDTSIFRLHGSLPLQTRLASLRGFSAVPSPKSTDVSSFSVLLCTSVASRGLDLPLVRAVIQYDLPTEGGATEYVHRVGRTARVGKGGEAWSIVAPSEAGWVKWVEGKMQGDTLEDVKGKNVALEGVPVETVLKQGFGGKGSEYEERATEVQLSFERWVLKDKQNAQFARKAFLSHVRAYATHPSDEKHIFHIRHLHLGHLAKAFALREAPTTVTNAGSKGRGAKAPAKRKTFHHEPSARDPRSRGGKPTETDNGHDIGDAEKRMEKVVRAQGRLTKKGGKMVSTGTSEFQIAGGYTLEKFVQGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF13</accession>
    <name>A0A401GF13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0304780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611672.1">
        <property type="nucleotide sequence ID" value="XM_027755871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF13"/>
    <dbReference type="STRING" id="139825.A0A401GF13"/>
    <dbReference type="GeneID" id="38777676"/>
    <dbReference type="InParanoid" id="A0A401GF13"/>
    <dbReference type="OrthoDB" id="3357304at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019036730" evidence="3">
        <location>
            <begin position="20"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="551" mass="61820" checksum="A27A8BC7328B0414" modified="2019-05-08" version="1">MGHRWVLCVLSYLISCVFAQNVSSGTDYGFSNDPILQFRPAFARSLPVQILLVGIVLTLSSVLLLHLIFTAQYHWPLAPVNFALQLSAVSILLISSIVTLQVVLSTATEQSRVWPYMLNYVAVDLPPTGTTDWPISQVAGWLLMNATTSVLIQITHIQFLTLLFPSTLERRLIFCLLGPLACLSAVMQMLRIHEGSKLEGLASAVQNVCNATLSLLFTGSLFVWGFLVNRKQAWRTDGGTAAFGAGALTLAPMSTAISFLYVPSKDQYTWMPPLMWSVILWQSFLGWWWWVGAGMGVGEIDERLQREEKRRRKRKMRLARRQVRRERAETLWKGVTGAFGFSRQPGAGEQGEEGEEAFDLARRRTRGRRRSSAESDRSAVSAGSDASKQPSSASTLTNASSSSGMFAQLWNHPAGRYMYGWFLHVRHAHLTAAREQAVEQVERINQVYGKEGGENSTNCRSAVGWGLGSFGTKRSVQRQTGQVNLDGNYEMEPVKKPRVGRGKENPEDDVQRVHVEEGRLPDTQQARMHRPTSMWWWGPLQRWRLQDATVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFR5</accession>
    <name>A0A401GFR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0306880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611878.1">
        <property type="nucleotide sequence ID" value="XM_027756077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFR5"/>
    <dbReference type="STRING" id="139825.A0A401GFR5"/>
    <dbReference type="GeneID" id="38777882"/>
    <dbReference type="InParanoid" id="A0A401GFR5"/>
    <dbReference type="OrthoDB" id="2553651at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="26051" checksum="F2175BAEB96857C2" modified="2019-05-08" version="1">MSYASVAAQNAPPPSAQPHPDPALLNTTAPSADNIADDAAKVNLVAPDFTSHPQTLTSLDAPRPQTVQGPPSPRPTNDVRDSHDDLWQLTKHYLFHPAVAGGSLGLINVGLISGAGYLYYSNPRFRTDTKLIASTVAAALSLGAAQSYAAEQYRKTPAGQEEERTAKLEGAALYRSAHEHFLRPAVLGGLLGVLNTAVLGTLGYFAYANWDRPHWDRRTVASISVALLTLWSGEAYLAERTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFS6</accession>
    <name>A0A401GFS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0307040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611894.1">
        <property type="nucleotide sequence ID" value="XM_027756093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFS6"/>
    <dbReference type="STRING" id="139825.A0A401GFS6"/>
    <dbReference type="GeneID" id="38777898"/>
    <dbReference type="InParanoid" id="A0A401GFS6"/>
    <dbReference type="OrthoDB" id="2792048at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="7908" checksum="14C29798B8F9B051" modified="2019-05-08" version="1">MVRNTRFDASWVALESGGAVSRADAIALVSVNLEKLLGFEAAGLDSDLVATHGGDLLGFSKIVGIVSPRRGIVNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG14</accession>
    <name>A0A401GG14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0308460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612033.1">
        <property type="nucleotide sequence ID" value="XM_027756232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG14"/>
    <dbReference type="GeneID" id="38778037"/>
    <dbReference type="InParanoid" id="A0A401GG14"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="119" mass="14131" checksum="218CD25598C27546" modified="2019-05-08" version="1">MSETTVQPVSRPRKRRLPRAYGYAFNWAILAPLARELDFPDVTLSNLVNTYFRFRFYLMNTWDVPNECFRNLSTKGNLTVGVVFADNCSRKRKKPDEDLVQRVKKAMKMEEDPKWYYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG32</accession>
    <name>A0A401GG32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0308640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612051.1">
        <property type="nucleotide sequence ID" value="XM_027756250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG32"/>
    <dbReference type="GeneID" id="38778055"/>
    <dbReference type="InParanoid" id="A0A401GG32"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27742" checksum="934D665FED876CCF" modified="2019-05-08" version="1">MRSHKVYFPKYDVPVRLRPWFLLFTSLVMILLAFLGFTNLSHSFPLNDKILHFFCLGFATGIFYFIFDVEEDARRIWFWRSSPLIFTGIICFFVGGIMSEFIQSLLPHKEFQVGDVAANLLGSSLGLYIAYQLERYYRHRREISRLYTPLDAEPVPSDDEGDVEATQLLPMHYQPSSSSSRNVKDGRGSKTDAGRIHLGNVWDEREELFDIGEDSDAEEEDRTARITPVPATPKIVVTSSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGI3</accession>
    <name>A0A401GGI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0310170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612203.1">
        <property type="nucleotide sequence ID" value="XM_027756402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGI3"/>
    <dbReference type="FunCoup" id="A0A401GGI3">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGI3"/>
    <dbReference type="GeneID" id="38778207"/>
    <dbReference type="InParanoid" id="A0A401GGI3"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019324777" evidence="4">
        <location>
            <begin position="28"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="968" mass="107366" checksum="115ED639AC463E5B" modified="2019-05-08" version="1">MTCKKFRARKASFIAFGIIAFSAFAQSSEFQEDAGTRTLSRAENDIEIVDPAAEASRAYRQALSTLAALTALPAPQYEDASLHQSSHKSASLLSAFLPSMQGHGPIASAMRITAKLFQHSWLPYSVTSYLGRETATVKKKNDEMQGKAVKVIDLLQHAAELGNTDALYTLGKISLFPPNGYFLSDPALGFSAFVTHASLTGNATSQAYIGFFYATGYHGIVPVDQAKVQLYLTFAGHGGDKGAQMAMGYRYWSGIGVTEDCLNALDWYEEAADQAMAKFRAGPPGGKTLPLMAPRLSDLDGGIYGPGASVASTGLNAARPVIKTANARAAGETWDDLLEYYLFNADRGETDFAYRLGKIFYQGSIYAAPGGVASGGDGASRVPRDLQRARYYFHLIARQVWPRDPSPHQSQSQAKDDNPAQAGYAALAAGYLGRMYLRGEGVKADPMMAKLWFERGAEYGEKECHHGLGIIWRDGLVDGRTDSKKAIAHFIAAATQELAEAQVQLGKHHYERGDLKLATTYFETAVRQGSPFEAYYYLAELQSSQARSSATPANIAGSSCAIAVSFYKLVAERGSWEDDLLNEAELAWNTATERGGEMAMLRWWIAAERGFESAQNNLAFVLDQDKSILRFTRFAPNSPSNDTARLALTQWMRSAAQRNVDALVKVGDYYYHGLGVPDEQEDIRWEKAAGYYQSAADTQMSALAMWNLGWMYENGVGVPQDFHLAKRHYDLALDTNSEAYMPVVLSLIKLHARSLWHTLMGGANGLSLWGDGDESGSYYAQPESREIESGKKSELSSGERAEDREEYEDGPWYYGKARDDYRRRRGQEAGRLNSEADDPVQWARDRRIADSDREGDFGPEDYFDAATRGRNREDEAVDEFTETMLLVVLCLIVSILLYIRGRWMDRTRREQQQPQQPQQQPHQQPQQLQQQPQQQQQQPQQQLQQQQQQPGGGPAPQPPPPANDWAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGL1</accession>
    <name>A0A401GGL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612222.1">
        <property type="nucleotide sequence ID" value="XM_027756421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGL1"/>
    <dbReference type="STRING" id="139825.A0A401GGL1"/>
    <dbReference type="GeneID" id="38778226"/>
    <dbReference type="InParanoid" id="A0A401GGL1"/>
    <dbReference type="OrthoDB" id="2801388at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="294" mass="31706" checksum="82AEF8013942D05B" modified="2019-05-08" version="1">MAERVDAWHDMYPGNLFSDGLGPSAAPPPNVSRDGRDQPPHMVSLWEIAKEALNSKELSSAYIEECLDDSATSVLEAGVALKKKTVRFNDNAAGKSAKRPPGIPASQVPTSILKPVSDPSVAVKGGAKASLASPGNQTMQYSYKMPVEDKVNVWDIFEHVQNEVRISLTHQELMALCPEIRKLEKEEITAKRVATTGSFKAADGEEVAEALLVDVSNGGGPLVVADDSLPLRAIDALVEGKESAERILDQGSQIITMRRDIWECIGSTLQSEKTLNMESANMGINQTLGRLANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGM3</accession>
    <name>A0A401GGM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0310570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612243.1">
        <property type="nucleotide sequence ID" value="XM_027756442.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGM3"/>
    <dbReference type="GeneID" id="38778247"/>
    <dbReference type="InParanoid" id="A0A401GGM3"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="66"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="223"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="9">
        <location>
            <begin position="1575"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1705"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1948" mass="215845" checksum="74D7151AD6BDF6C3" modified="2019-05-08" version="1">MESMQPLILSPRWRPISSAHQYLAYASSSKHAVKAEESNLLKSIRATLAGSRGDSDATVHSTLYSATEDAPGDEELSWDAHTVVLSSGGIIRQRFNFEDEGEPVQWACIGYFEQPSAVTSASSMRPAHYTYCNPEMSTPVSDSSQRATFGPFARAQQEQKREHEPGSYARALFVFLRSIGKIFLFGDMDYTFNLPFIVRRAWPLHPYGVMIQRVVDAVEVAEAKTSQESLLPTIFTLVHPFAEPLAVCSAEKIIGGFHQVPASLKDDDSHKSMNFVDAEEHIVWLSQRGFDLSDQVMVTINATTSQVSLWRYALIKPQDAAASHERPRPRTKANKRASMTGGTPVHRRHVSIAMGEAPAHANGLSAQGIYMLSLSALPGMPPSLSAAATMAALVNGTSSEPQRPGKRQHSISKLDLSVTMDQMVSNARVHAEVPPQPVDTAKMTPAYWMEKLYTQEISASDAASLGDISAAQFDQRWDGSVNRSLLSVCLPRTDTLLIFCVTKHGDHTLTASPHTRLSACSVAAIRATRDTVRDLLVLRRDGGLAVLTHGLYEVPLQFTLPERDGGMDMDIDPPPNSNFKPQVPSDGGVIAIEDALDSSITVVFSNSSRFRVTINLMPHDATARQCLLMLAMILPADTSFALHSRFLSKWSQQNFSIVEDVEFGAFTAALYEVLQLERPDPVPRPSIDPNISRPWPALAGSTSYSRFGEDPALQSLQLPPPSLRTAYVCKQPDKPTHPLLAPVLNALHYVAEDMRCLVYKHPALLKLVPVICRIAMVVRPEWADFWKRLCPEAIDVWPSPATTVIAHLDERLPLWPPDMSAILYGRINNPEWSIPWPESQEFGAQFKINASFAYGRTEPLARIHKLTAVYMCLADSKVAESRKRAENALRMLVKSQIGLDVLRYLPIGIAAPLREAARTCQLAPSGDWSVSAYQLIGRNDLAEGLSSSPDTLTSYGYRSAKDHTIFSAPRKTIREQIEESCKTAGELGVVSGVELDLKDFTHIRFGQDRRLEEVARMLCSSSIPTIKAIDHPELSEHDQAKENQHQVVRMAERTLALPLGRALFTFGSVPTVTREAYAIPKLEFTVRLQPHSMLITPELGKVPPECLSWGEFHNGVAAGLRISSQSNAVESTWIKFNRPSDLTPEHAGFLFALGLTGHLREMLTWHTFGYLTPKHDMTSIGVLLGLSAANAGSSNPHVTKLLAVHTPALLPTPTVDLNVPLITQAAGLTGIGLLYMGTKNRRMAEVCLGEISRKDLYQPDLSNEYREAYTLSAALACGMVMLGKGSSIPADLNLLSRLRVLIHGEGHTMVDGKSQRPSFDINLTSPTATIALGLMYLRTERQDVADILTIPDTLLALDSVQPSFLLLRTLGRALIMWDRIAPNQVWLSAQIPPNIGMAMNGRFQGKPVDDAYELAYYNILAGGCFAIALKFAGTAREEAYLLIIHYYDMFSQLTYTNSPAFDHRIKRSAIRDGLNLISISLNMVMAGTGEINCLRRLRYAYGMYNHPIRYGTYVTTHMSLGLLFLGGGRFTLGTSDAAIACMIAAFFPRYAAISSDNKSYLQALRHLWVLAVEPRCLIARDVDTKEVVYLPVKIKVKEGKDVGTTQLISPTLIPDLDKLLSIRVDTPRYWPFYLDIANYPRHKDSLLRSQTLFVKRRTAFLSYMEDPKGSRSLFVRSGSSTGDAATLDFPQLTELKTHPASDLHQFISSFSNDALFLAFADRFCRDDGETTQERLLHSYCHASLLDSILQDKAQTIQSHLTLFRYRTMSLKSRYFSLRAQDLRFATDFYNKVYDRRFGGRAENNPRPPLIRENTLSGASHALDLQLDHIRDTAVFKRILGHYARGEAIPAFSVGSAEHAAAAYLSWYLQRNNVPVSTFLHMLKRLANDAHVQCLRMPPPQGTTDAMLLDKGIKEILHATGTQMSTTMGSGWAIRSLDEVIAAWNFASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGT8</accession>
    <name>A0A401GGT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612327.1">
        <property type="nucleotide sequence ID" value="XM_027756526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGT8"/>
    <dbReference type="GeneID" id="38778331"/>
    <dbReference type="InParanoid" id="A0A401GGT8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="49" mass="5325" checksum="2D83537CBDB8FEF5" modified="2019-05-08" version="1">MPSMMGVVIPPQLLLPLLRLHDGRASEPNVHAILTLLLPRMSPISAIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHL6</accession>
    <name>A0A401GHL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0400510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612593.1">
        <property type="nucleotide sequence ID" value="XM_027756792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHL6"/>
    <dbReference type="STRING" id="139825.A0A401GHL6"/>
    <dbReference type="GeneID" id="38778597"/>
    <dbReference type="InParanoid" id="A0A401GHL6"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="483" mass="54846" checksum="D3DF7E91CBFE8B8E" modified="2019-05-08" version="1">MSHGATDGHCSLTTFHDLPYEMLREIFSFMPAGDIFSIITTCQALYKALNQDESLWKELSLRYGVTDIALFEGRSFRTIYTRFLHHYGALLGLWASDHPFKGNIMEYRIAPNRWGPGKSHVVIGEVWRFPLTRNQTATEKREPHLPQYVEFMQVGFGLEEGDDVDAVCVTWHIHAEQSLLNPAVPFDRHDESSHYSKPVMHLITAFHGPIPFHMPSAHHNGNPMAHPDFPNSSTIAWYDPTRGYPNVQLMACPNEDKNLSGNNRPQQWQNSVWSDYADDSDPEDDSDPEDDSDIEDGTVTPKRFPKPVALSFYGILSNDLLQLHTPIHGFYDPRQDTAPRYFPMRGDIEFGDDPYSSSWRAESLRGLWLGSYGPHGTECLHLESVPSLQAVHARKVTGDANVPRGVISWAMQLNHPVTHQQLMDDEVLEGQVARAFAGRGTTSGHGFISPEKVKVTVLIISRDEIRVNWTKSYTNKYIRYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHP2</accession>
    <name>A0A401GHP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0400060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612548.1">
        <property type="nucleotide sequence ID" value="XM_027756747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHP2"/>
    <dbReference type="STRING" id="139825.A0A401GHP2"/>
    <dbReference type="GeneID" id="38778552"/>
    <dbReference type="InParanoid" id="A0A401GHP2"/>
    <dbReference type="OrthoDB" id="8964853at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328:SF3">
        <property type="entry name" value="PROTEIN MAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10328">
        <property type="entry name" value="PROTEIN MAX MYC-ASSOCIATED FACTOR X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="220" mass="23496" checksum="D036E29085CCFD83" modified="2019-05-08" version="1">MVSLIWGVPACAGGDICRGQTRPAASHPRRTWFSSDPPPHPSFPLAPSSPPTPAVPRIPPGISRPLPASPNPPIPQASSHQTTQAANYYSLHSHMAVPLTIPSSPSAVNSPTSTDGSNGPQTPVSPTTSVQTLALPPPVDGGTCPRRSQRANTAERRATHNAVERQRRETLNGRFLDLAALLPNLSQIRRPSKSSIVNSSIAHVHSSRRHRLLPRESYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI14</accession>
    <name>A0A401GI14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612725.1">
        <property type="nucleotide sequence ID" value="XM_027756924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI14"/>
    <dbReference type="GeneID" id="38778729"/>
    <dbReference type="InParanoid" id="A0A401GI14"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8211" checksum="D0503777CA79F3A6" modified="2019-05-08" version="1">MWDFIVADSSSNPLYPPHDGHPAYGVGVPDVGQTQPDTPSPSSTSPIAHPSPQHANQLIVTSSTTRSVAFMNHHHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIB2</accession>
    <name>A0A401GIB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0402830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612822.1">
        <property type="nucleotide sequence ID" value="XM_027757021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIB2"/>
    <dbReference type="GeneID" id="38778826"/>
    <dbReference type="InParanoid" id="A0A401GIB2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13866" checksum="0DC0BFE732BCF74A" modified="2019-05-08" version="1">MAVSRILVYAWIQARNASPRRCRSTGTAHTWHAETMSPVDPCVLLTSPTPQPEKAYIWLGSRKSRRGRMQAHSKSLDTYPKVVVFTSSARKNRQHGRQRYYSFPQGPQEARYHHSNTSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIM7</accession>
    <name>A0A401GIM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0404050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612942.1">
        <property type="nucleotide sequence ID" value="XM_027757141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIM7"/>
    <dbReference type="GeneID" id="38778946"/>
    <dbReference type="InParanoid" id="A0A401GIM7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="5732" checksum="8CBEBB69F142C495" modified="2019-05-08" version="1">MRLFSPPRRDTLLNYSDNVSKPPQANRDDLIPDALVPPVPVAHTNPFTSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIX7</accession>
    <name>A0A401GIX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication protein A C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0405400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613073.1">
        <property type="nucleotide sequence ID" value="XM_027757272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIX7"/>
    <dbReference type="STRING" id="139825.A0A401GIX7"/>
    <dbReference type="GeneID" id="38779077"/>
    <dbReference type="InParanoid" id="A0A401GIX7"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32268" checksum="D72573A02DD66A04" modified="2019-05-08" version="1">MVFNSEAILRALRPVTIRQMLDAKQLHSLAHFTIDGYEIDTITTVAHVLEVEIHDSYVDYHLEDGGTSPGQITARHFHEENQVPIDADEGLPYARIIGQLESRFENNCVKVKHIRKVIDPHEVYFHFLEALVATRYLEIGPPPPIEVRHLGDGASVLEQELITESSSPPSVAPLTQDVDLAQGVNDMDIDDSDHDDGERAGDCSNPSIRNDDLVHLTALQRGIIEQIRKYEQSPDGAGVRAIARGVRHLNVTAQEVEQAFDLLTDKAYIVTTIDLSHYKLTKKSAASTDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ15</accession>
    <name>A0A401GJ15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRN6 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0404810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613014.1">
        <property type="nucleotide sequence ID" value="XM_027757213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ15"/>
    <dbReference type="STRING" id="139825.A0A401GJ15"/>
    <dbReference type="GeneID" id="38779018"/>
    <dbReference type="InParanoid" id="A0A401GJ15"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="139"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="930" mass="103925" checksum="2D569865CD996154" modified="2019-05-08" version="1">MSSESVVDRWPSDETKTSVTIVRQKGKKTVKESPWRYPSVEPGSLTSATLRRYADRLHWSFLCEKNSGRRLFSKQDPIEVFPQTQQHLSNVSDLSVAQRAEQGAHFLRTYYPDVDIPSELIRDEIAADAGAFHELRKFDPLAGSMLEVFSLYTGNREEGTYLAFPMGESYCDLNVSPLIFTQRDHISLRSSAKPIKSFQTPIQQILSPAPSTEGERSETVLGVRTYAATSLLQVKPMGDSRSAAVQMHELAVVARSDVGDKLLMDMTLPTTSTRHGSLLLVNQEGTVYQCSVPRGQKFIERLYTQPTSSQADPQEQYWRIGTWKDNYSCLLMGRKYAEHLDLRAHDSSSVLYHASNAEDFLISIEGRSEDHVVRLVTSDEVVWIDERRPGTPLLGMKHGRGSDRTLTTYTRLLMQSPLTFLTSRCNGLVTVYDVSGTDHNLVYVNVPPYCLPPVRTPDGRYLGHAFVQHPADTNDGDISVMQLSESGSISLLNLELSPTGEAGDVTRIDNQRVEWPVDVLNLEAQVKTSRPNNGPLGAQTFSKVDLRPAYKRIFHFSEADLPAGDGEAVYQILDKMPSFLQDSDVPVEHILTTYDISLRSGAHPLQATRSDILTESAMNSVRGYRALVQDRIPVKQLAKSSRWHMNIAPFLHHFIPDMEEHLEKTVDRLKQYNLDSDTDRPAVSYRRESESREQLLLDLSLSSNVFAPHPFMRAGEPKDGIDPNLDNVLETMSRATEAMSLQDAEPPPVTFGFLRPVDKRSVEYYTRGKTERTPAESSRDLPLSLGVRLLLKDWDIGADPDTFSYHDLYEISNGVPKVQQRRTRYKPEVAQPLMEDLGIQSQRPPPVLASSAMAPFAIATSHQSLVTRKPLTGARSQEVILGGSQPEEGGWNAPPSSQNFMTSTQVLPGPHGGRPLPAKKKLAKKRIGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ88</accession>
    <name>A0A401GJ88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0405720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613104.1">
        <property type="nucleotide sequence ID" value="XM_027757303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ88"/>
    <dbReference type="STRING" id="139825.A0A401GJ88"/>
    <dbReference type="GeneID" id="38779108"/>
    <dbReference type="InParanoid" id="A0A401GJ88"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="111"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="473" mass="52962" checksum="4875E364171DCE99" modified="2019-05-08" version="1">MDEDLIVVDDVEEQVAGPSGTNGATPSDIQPVHQTRSGRTVRTSSRLSTPPVYTAFDNAEGRTTRSAAARSRPQPKLKLKLSEKAAAQAPGMSFLGPYDRELDSDDEDLVFEEQFVLRVPPGEDCERLKKAIANRDVGNDVWFKFKDSRRAVFHIGTNTYSAKLVDLPCIVEAQKTLDNKQMFKVADICQMLVVQDRIENEDALTNQKSFNIDEFIWPHGITPPLHHVRKRRFRKRVNRRTIETVEQEVERLLEEDALAGEVKYEVLENVNPDLSDSEFIEREEPVDMATPFLGSDAEAPTPGPGEGEGEDEGEEGQEGEEGEGDIDEELAAELDLALGDEEAEGDDEEEEEDEEDESEEEDEDDDDETVQARKLLNEEIRDLEAAVAKKGSEIASSSNPLIRRRFEDALKKLQADLDMKLAQRDEIKEKTRMRKEGIVFEDADTEGGHEDGDVADDHDDLFGDEPGVGMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJA2</accession>
    <name>A0A401GJA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0406270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613156.1">
        <property type="nucleotide sequence ID" value="XM_027757355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJA2"/>
    <dbReference type="GeneID" id="38779160"/>
    <dbReference type="InParanoid" id="A0A401GJA2"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE82243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="240" mass="25745" checksum="7B1E1A0E702A5F04" modified="2019-05-08" version="1">MNECSFSTLSEAENLNKRDAFDLEVNVLAQNLLEHLWLACNELDGVFLQFFVVVSEDAVAATLKSPHQSIDEVERKTNRAKDEHAQKGKTLRCTGIGAVAGGVLVGVTGGLAAPLVDANISTIFAWLGVGGTAAGLLASGLASSSVVCGALFGAYGSKRSAEVVSRYTREVEDVAIVPVRQPKQTLAVRLCVSGWLNSPEDVVTPWTVFSGDDTFSLQWRRCRGSPMCLRLSLKPRLCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJG8</accession>
    <name>A0A401GJG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0406840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613213.1">
        <property type="nucleotide sequence ID" value="XM_027757412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJG8"/>
    <dbReference type="STRING" id="139825.A0A401GJG8"/>
    <dbReference type="GeneID" id="38779217"/>
    <dbReference type="InParanoid" id="A0A401GJG8"/>
    <dbReference type="OrthoDB" id="3264915at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19622" checksum="287382E1029EBD3A" modified="2019-05-08" version="1">MSLRAHGSEADYHIQQLIDLFREIDAAQDPTPSSKYIPRIKAVETIDEPPKVSKLLKNKARQWMIDPHWLAVETNQQYDVESRIVNSGRAWGDDEDLEETLEKQKRMREEKAVIVKNKKARLAENAQDKGEGSSKQKVAKKKGKGKIVKVSTGGDAGKGQNAAEDDDDDLYFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJQ6</accession>
    <name>A0A401GJQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0407790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613308.1">
        <property type="nucleotide sequence ID" value="XM_027757507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJQ6"/>
    <dbReference type="STRING" id="139825.A0A401GJQ6"/>
    <dbReference type="GeneID" id="38779312"/>
    <dbReference type="InParanoid" id="A0A401GJQ6"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="3">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="222" mass="22946" checksum="32611ED57998C93D" modified="2019-05-08" version="1">MVSQPATKAISKKAKTSRVAPAPKADVKSTASHPSWKDMVKDCITEHSQDARTGVSRATIKKFISEKYNVEFTGMNASQLNRAIAHGAEHGIFSLPKGPSGKVKLAPKLKPAPANENVKPLGTKKTNKDTSAAAPSAKPAVKKVAVKKATAAPKKTSSAKVEKKKPAAKAAVAAKAASKAKPASKAKTATKKTAAKPKSAAKPQSAAKPISATKPRSTKTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKG0</accession>
    <name>A0A401GKG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Postreplication repair E3 ubiquitin-protein ligase rad18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SCP_0410460</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613574.1">
        <property type="nucleotide sequence ID" value="XM_027757773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKG0"/>
    <dbReference type="FunCoup" id="A0A401GKG0">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKG0"/>
    <dbReference type="GeneID" id="38779578"/>
    <dbReference type="InParanoid" id="A0A401GKG0"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="23">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="114"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GBE82661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="400" mass="44383" checksum="D24936AA681B3CBD" modified="2019-05-08" version="1">MSVNDLLHDTDIQDPSDFPPADVAPGVRQLDEALRCSICRELYQAPVTISCGHCFCSLCIRSVLQEKGECPLCRQSASDTKIRRNPALENAVKAWNLARAYLLRLFNEEGTRTSQNGFALSTPSELESEKSSKKRKRATSEEEDDEVQVVSGPSIPTPSGFKAKAMKSSPQSPATPSSLNNLVQCPVCQKDVPYDNINTHLDSNCRELRVEGSTSVIHAAGDKGKQKQEWSKILGGATRKGKEKERAKSSEIAEDTEYLPKVSYHTLKDSVIKDRLLEHNLPTTGDRNTLNKRHAKWVMMFNANLDQSSTDRKTLSQLRRELQTWEDERKARKQVVTDTTAYEKAHKAEFANLIEAARPRKVSDRGHVAEEATRAGPTAVQDTATSSENTIDLDADDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKZ2</accession>
    <name>A0A401GKZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OPA3-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0412240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613750.1">
        <property type="nucleotide sequence ID" value="XM_027757949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKZ2"/>
    <dbReference type="FunCoup" id="A0A401GKZ2">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="GeneID" id="38779754"/>
    <dbReference type="InParanoid" id="A0A401GKZ2"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="229" mass="25116" checksum="764587980DA6793B" modified="2019-05-08" version="1">MASAAAKVATLAIRTLAKPISSQVKTQAKQHKTFRKICVSLAQNMYKAEINLRTNLLGEPAKHVRPLSETKAIENGANALAEGFLFGVASLLILGESWRSSRTSSKRRDIVDEQLEELRSSVSQLTDKMDTVAKDYEERFSEEKQRNDELTRILQRVVEIGLRGGWAEFEGTPLVLPRIELVPQTSRIQRSPGPSSNTVDSDIPSTPSSASSEEAGATPLSSESTPRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL21</accession>
    <name>A0A401GL21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0412310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613757.1">
        <property type="nucleotide sequence ID" value="XM_027757956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL21"/>
    <dbReference type="FunCoup" id="A0A401GL21">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GL21"/>
    <dbReference type="ESTHER" id="9aphy-a0a401gl21">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="38779761"/>
    <dbReference type="InParanoid" id="A0A401GL21"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="91"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="341" mass="38051" checksum="108E7F5459FF9B4A" modified="2019-05-08" version="1">MSQYRHLSTVDPEFAVIANQFPRDALEHDVVALREKQRQSNSILQEYLKPRLPRESELRVIDHKVPVENGEITVRSLVPSATAEGKTFPLLVWFHGGGFILGDLDMDDYRLRILCVELQLSIVNVEYRLAPEHRYPVSWNDSYSATKWAVDNALLLSASLDKGFIVAGLSAGANISGYIAHRARDDPFFSKTPLTGHVMQVPPVLNPEAPEVEKYGAELLSMEQNKDGPVLTREGIFNFTRITGIPKDDRIFSVLLQPSHAGIPPLYVQINGLDPLRDEGLLYAKLVEEAGVKTRVDIYPGVPHGFNYFVPQIKAAIKADRDLDEGIKWLLSLANDSDSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL55</accession>
    <name>A0A401GL55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0412770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613803.1">
        <property type="nucleotide sequence ID" value="XM_027758002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL55"/>
    <dbReference type="STRING" id="139825.A0A401GL55"/>
    <dbReference type="GeneID" id="38779807"/>
    <dbReference type="InParanoid" id="A0A401GL55"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="32568" checksum="1930793CC43E31D5" modified="2019-05-08" version="1">MLTDIPLIPFFLAAGLGLQGLRTRSLSPSGALAAFVVGFTMMAVPLRVFGVSLIVFYLVGSRATKIGKQLKATLEDGHQEAGYRSAAQVLCNSLSALVASILWSAFFVPNSLASSVLAGAFEPQKSYDFAQWCPLTPPESAAWSRPLLFVTLGHFACCLGDTLASELGILSRSPPILITTLKPVPPGTNGGMSVTGTLASLGGGLIMGLTVAVSLLVESSACRVQWVDVLLPLLAWGTAAGGMGSLLDSLMGATIQRTRYSAATKRILTDESPAPAVDAEIKVVSGFDILSNNQVNLLSSIVTAVTLGVLTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLF1</accession>
    <name>A0A401GLF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0500330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613903.1">
        <property type="nucleotide sequence ID" value="XM_027758102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLF1"/>
    <dbReference type="FunCoup" id="A0A401GLF1">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLF1"/>
    <dbReference type="GeneID" id="38779907"/>
    <dbReference type="InParanoid" id="A0A401GLF1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="656"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="992" mass="112146" checksum="FDF22148032D12A7" modified="2019-05-08" version="1">MIPVFGDDPIKRRREINLGGAHSAVSYSDILNDAKAKRLRRLDVKRREEAAISIQAWWRGHSEARFVKQNLLCTFQEDVTSLRGLRCLVLIGQDEEALGAWSAAVVNGQQDVLLQADASWRFLLRRTALLLLRSLSNAPESQYAVMHLTVLNQLLSGNAYTSEYTKYLLDHGFYFLIGQSMSHIPIERKTSPSLPLLTTLITLPLSNAEFLRQSFQDFIIHIFSIPLLPNRLSLPLLTSLSARLPLSSIHVLSRSVADIVGNPLLSLPEAKVHLLANMTAFMPPRYEKLPARSFDTYLQLTAALMNSLPTQALEPPEKKQETSSHWADGDDADDEPRVSVVSSFDAKLQLPQLDGRTLKRLQTLPSPQHLNSLLAATQSRSSRSDLLSFLFALTTVWPTRRDKVLSTVFAYNGGGLVREIYRSYVRGSPLGREDDAGSMTNTGNASLWPPLLFLVDLYNQALLTMGDDEFFSSNSSVNVARNPLSVDELTSFSRQLLNIAFTLYWKEDQTNVQEGGVPGLGILKWEDVRVKITKCLQAIHARDSRRPFTPADHWLITSQVDMTTFVQAAVFEERQIAQPEGTRPLSKRQVAYLSPRLGVLNNIPFAIPFETRVSIFRHFIANDMLSRGVDQYGRRFQTRVTVRRGMIAQDGFDHLQDVDLKSPIAISFIDQFGQEEAGIDGGGVFKEFLTSLCKEVFDTDRGLWLANQKHELYPNPHSYATETHSLNWYRFIGRILGKALYEGILIDVAFAGFFLAKWLGKQSFLDDLASLDPELYQGLIFLKHYTGNPEDLSLNFTVAEEEFGVAKAMELIPDGSNIPVTRENRLQYIYLVSHYRLTKQIKLQSEAFFEGLSEMIDSKWLRMFNQQELQILLGGVNSPIDLEDLREHTHYGGLYDDHEPTIQVFWRVVDSFDQEQRRKLLRFATSCSRPPLLGFRELVPNFSVRDAGSDENRLPTASTCVNLLKLPRYKSEIVLRDKLLQAINANAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM64</accession>
    <name>A0A401GM64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat protein 39B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0502860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614152.1">
        <property type="nucleotide sequence ID" value="XM_027758351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM64"/>
    <dbReference type="GeneID" id="38780156"/>
    <dbReference type="InParanoid" id="A0A401GM64"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="69954" checksum="7E922889DEC2ADC3" modified="2019-05-08" version="1">MQRPSSRPGTYTQESALDDLPAIKYAMSLFLNSDMVEAEQYCDELDPNKERLYITVGYSLIQCLKAFMSYEDKDLDEASIHVQHGNQLAARHRAPPATIVSQVTNFVRGAPSLEAIKAMTATQRHAELLYAEMTFAKAMLATARTGSWLAFVREAARFRVMINLYLQLGRYVDLMDAEAAARGEAEDRSIDRDFRSGVELGVGASNLILSLMPKTVITVAELFGYQGNRMVGLSLLMKSGGWTPTSSEPAVSIEEEGLRRPLCDIGLLAFHVILSDFVFQGVDLAIARNILQWNLRRYPKGVFFLFVEGRLRLQCAQPALALESHHKAIAVQSQYRNFHYVSLWEIAFCNMSLWEMSASLDAWRILREEATWSRACYSYGAAVCLLELGAPENVREAKQLLDGVPGLVQKLAGKSIPAEKFVSRKARQFKAQGGRLLLPALEFCYMFMSIEQAPRAVVRYKMLPEVESALVNLKAHESDPASYEGGQRYWDDFCLAHFLEGVCLRYMAYPDANAILDPRDDFNIPRNTLTIRAMDAFNKVLSNSARIRLDHYLIYHTHYELGRLFARVGNEKKTREHLELVVSQKPLEASPKVRKGKYSMQTVLVVRAAAELEKLYPKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMX0</accession>
    <name>A0A401GMX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614469.1">
        <property type="nucleotide sequence ID" value="XM_027758668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMX0"/>
    <dbReference type="STRING" id="139825.A0A401GMX0"/>
    <dbReference type="GeneID" id="38780473"/>
    <dbReference type="InParanoid" id="A0A401GMX0"/>
    <dbReference type="OrthoDB" id="3250555at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113698" checksum="44DDB965A2B2C056" modified="2019-05-08" version="1">MLLDLPDLECMERPEGRSASEETLQSTTVTHSFPTGFFFLSYQSFSSQSWCQTSSNLTSLSATQPLITLHLWQTLTSSFFMTLSPVNLPFELPNEDRPSRLPSPLANSDDAYSTISAGEFGSVHEGSDPDACTGQEMSSDGLVPASSSPVFSSPTAAVTPPDNDYGGDISSYSFRPIVIEGDGSVGSPGDFSADSDDGLNPCLRTSEACKEQTSLTVSPSSSSVHREYFTNGSINVQSSGDVDGCKSVDDDMAICSPLPSRSEPSFLCRVNDMLLAVQQERRQAEFRQRIVNRPNETGSGTHVHAPATSALNGPSSETSILLGNPDNRSGRTYAVSTLFSPVLYSTSVMASASDSDGTSSSAIVSRSIFSGSTSQSGSTQSVSRPCSLSQSQPYNANSDRDKPISADQSSMDVTVERTYTYAHAGDPEGRHLNVDSLASPASPGEQRKNEATSTEPQASSRPVLGLKRQLSTRGAPPAREVNRSPLNKRKSCAYTHSEESDQYQVERGRKRVRLSMESRFFKRKDSGGLKSKPRQEEPNASMNRAYAKVPASLRRAESLMSEASMYAEEKENLDPRGHADDEAKSSDSTPHDGSSSFASSGKSSNRTPKTFYTPEYHYIPTAPATPATPVQTRRGVRSTRQRSHSRTEDLAAVPIIAPPPFEMIPRGPISAEDSAEQRITVMLEKERQQREEDRLGARSQRTSGPQADEIVKDEHDERNGADEQVHAWRAGVNAGNPEEAIKVKIEDKYGEESVFSRMPLFSLGIEEGLRREVVEWILDVVPGTYPTKPKFCLHLRDQLTTSEETRFHAAYLFMRYFLRVGSGPESPKARGMDMILLREGREAVTWDVAVACIALCVKFHRDALLPLYIILACEFLSIAPHSISNDDLEASQRDVLQTFSFSIGSITPESYMQELWLALPSLRKLLGFDNGWKVAQTEAWSVLLDALLQEDMLRFPVSLLTASALIDGVVESLARRYMEESFRKVGWLTTSCQCKQFRKKAIKAASGFMLDIQEILGYSAKDLKFCRQWLRSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNC6</accession>
    <name>A0A401GNC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0507720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614629.1">
        <property type="nucleotide sequence ID" value="XM_027758828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNC6"/>
    <dbReference type="STRING" id="139825.A0A401GNC6"/>
    <dbReference type="GeneID" id="38780633"/>
    <dbReference type="InParanoid" id="A0A401GNC6"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="203"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="988"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="876"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1116" mass="122016" checksum="E8D2FE2A4F4A1DAE" modified="2019-05-08" version="1">MSPSSTTPPALQEATRNSTVTWQDDLKSLFVHAKDRFADVVWELADEKDKAKGVEEIWGHKAVVYARAPPTFQARYFSFKPPPATSPLPYSSSPTGTLPAQSALSLSLGLDFRSTHSRSPSPFRAVSPAPSTNTGALLRLPTPINPTLFSNELEYLYTGKGLGAAFEFLFDSAEILEKGDGEDARIDKLRKDLVFMWRSRLYSDVRITLTGNFSSSNHENATAIFSSHRFILVSRSPYFHTQLLSWGVQSTPGEPLTLTLPSPPFTPASLHFTLGFIYTGTLVFSHRTFDLDTAFHIMRSASYLSLDTLYDEIQARIVQEMMHGLFHAFLEFSEYECITGGKWGTGGCRCRQCARRAPRVLEFAVTDDVKNAYLERGARRALVGLFGEGWCTSEFAGLSQKTRDSLVKGLEKRTTPINIFPLLFAAQVALNKLNSTIESWAEVSRDMIIAARKHVDQVLCAQADQCFEQPEWLEIMEANGTNFDHAEQVELIMQSLRRGMNEKNAAMLYQTLVSSILLRTDPTGPENTMLPMTSPIRRQVDEVRMDVLRWLRRRWLGVKQEGGFDALESWAAKEIAEEIEVDVEELFSPVSTSVPPRGPTPKGGLRPSMIRGDENDTGSMHSLRTAIIRKNGDVKPSAASVRSLARSTHSTISRTSTAVAMRRAHGHRPDSKLTPTTSIALSSARSSTADSDAVKAPTPPPKSTVPSIIGRRNISSSTSTHDNIFRPKSTASVRSAHSTVSTIRKTVAGPSTLRPPSGLSRPSSTHSATSEGSTTFETAKSEVTPSSVSRPRRGSATSMLSTASVRTTATSTPRVAKPRPPSITKSITPSVRSKRPPSSPVDRTKLAPAARRTSSAASVRSTTSTTSFPAKKVLLKKPSSTSSSPKSISRSVSGDVDEGMGTIKGKTRSTTLASHEKQASVVSSSSQSTARGSLKRKSSSDTIKESSVGDALAREAMGVPRGATLDIGIPCIISSKKARFRAYARYIGEVEGEAGPWVGVEVPMNDTWPGEKLDGRQWNDGSWGGIRYFDIGGSQSEWEFGEERAARRRRIDWVNNLGRDPKTSLKREGEQLSIERAKRLRSASPAVSDMSTSESRGLFVRPQQVLYVVDAVGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNS5</accession>
    <name>A0A401GNS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614788.1">
        <property type="nucleotide sequence ID" value="XM_027758987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNS5"/>
    <dbReference type="GeneID" id="38780792"/>
    <dbReference type="InParanoid" id="A0A401GNS5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="136" mass="15672" checksum="2BDD77537F844252" modified="2019-05-08" version="1">MTWTSRWASTDVQHSRCPHCHYLFPQLHVSCVRVLGVNSMGSQAPTRKIESNPWTTLSSSPFYPQLLPLARIHHQRQDSERLIPGPDVVDEWAHQALDLANMISRRASDVRTVREFPRLTLEDGKALFLFLKCHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNZ7</accession>
    <name>A0A401GNZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0505230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614387.1">
        <property type="nucleotide sequence ID" value="XM_027758586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNZ7"/>
    <dbReference type="STRING" id="139825.A0A401GNZ7"/>
    <dbReference type="GeneID" id="38780391"/>
    <dbReference type="InParanoid" id="A0A401GNZ7"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019052657" evidence="2">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="465" mass="49990" checksum="5D3D5DCFDD9F375A" modified="2019-05-08" version="1">MIGLAGALLAYASTAYAATALTFQPPALSPTSQSSNYTGASNNTITNGPVVPGKSFDRIIQIWFENTDYETAITNPTFANLTSQGLLLTSYYAVTHPSEPNYIAAAGGDFFGNAADDFRAIPSNISTIVDILEAKNISWSSYQESMPYDGCMSYNYTSYDYVSGTGNYTYYVRKHNPLIIFDSVSNVSERALRIRNFNDFANDINHGPLSQWTFITPNLVNDGHDTTITYMANWTEYWLLPLLRNPNFNDNRTLIFVTFDETETYTINNRIYALALGGALPANLVNTTDDAFYTHYSAISTVQANWDLQSLGRQDANKTVNNVFSWVAATANWTNNGLIANSSNIPLLNLTGTIAGPLNPELYLPFTAPDASAMGPGAPGVFVSPGTNTSFTTSDLPAPVNLTNLGQPLPWSASPGYDYVNGSKAPANVSTGASPSPSPSSSGAERVFVPVLGAVVAAVGAMVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPG7</accession>
    <name>A0A401GPG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615038.1">
        <property type="nucleotide sequence ID" value="XM_027759237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPG7"/>
    <dbReference type="GeneID" id="38781042"/>
    <dbReference type="InParanoid" id="A0A401GPG7"/>
    <dbReference type="OrthoDB" id="2742220at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="329" mass="36856" checksum="9CE57459A45BD2E2" modified="2019-05-08" version="1">MVDWKDPEVIELTVFVLEQTIVFLVGFYGWHFLLTIHVEWNLLTRKLVFKWPYVPYLLGRYTMICCLLFVLIMSRLRVKEAHCRAMLDAESLVACMAVCCASMNLSIRTLTIWSCSMRIRFLLITLCLGHWAFAMVVAFTGLKAQYDAVSGTCVLANTNGIDRLAGFYAYTVGYDFIILVLTVYALYRSCKRSELLSVICVQGVWYFVVTFLVNIISVTLVLMDLNSAMSVLFSLPGVTISAIASSRCVLSVLSMADLFGRTREANGHTSWLSKLGLPAGEPVLLTTHITLNPSFPDVDSSTSDIDDERWSQEAFPDVHHADRSIPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQL3</accession>
    <name>A0A401GQL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nonmuscle myosin heavy chain b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0604740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615408.1">
        <property type="nucleotide sequence ID" value="XM_027759607.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GQL3">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQL3"/>
    <dbReference type="GeneID" id="38781412"/>
    <dbReference type="InParanoid" id="A0A401GQL3"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000002">
        <property type="entry name" value="Myosin heavy chain 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="77"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1279"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1634"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2211"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2326"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="900"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1738"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1813"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1288"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1643"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1675"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2211"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2231"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE84495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2347" mass="267927" checksum="0D06D19BC0F8B6F1" modified="2019-05-08" version="1">MPAPRPSQSAEAARAAALQAEFNEKKWVWVPDDKDGYLAGWVIKEEEDIGEVVIASGGEIRRLPLYALSKMNPPKFDRVDDIADLTFLNEASVVHNLRLRYGSGAIYTYSGLFLVAINPYQALPLYSDAIVHQYRGKRRDENPPHIFEIAERAWINMGDERENQSILITGESGAGKTESTKKVIQYLAAIATDTHPPSTSLHSASPSLTSSSSFGAIVSSTGLPRNSSLIKKHGKQTSMSASSSGLTAKGRLGLLERQILQANPILEAFGNAQTQRNNNSSRFGKFIRISFSPDGSIAGANIDWYLLEKSRVVVRTEAERSFHVFYQLMEGGGNLKETLLLDGGVEDYEYLNKSRREVDGIDDSEEWKALKNALDVVGFSAAEQFELFRIVAAILHIGNITITSTRSDDAVMPDPSQAERVCHLLGVPVAEFTRAVLRPRVLAGREWVTQARTQQQALDELSALCKTLYEKSFGQLVDRINRALDRPSSKSTFIGVLDIAGFEIFDINGYEQLLINYTNERLQQFFNHHMFVLEQEEYTREGIEWDYVNFGLDLQPTIDLIETSGATIGVLSLLDEECIMPKATDLTFTNKLHGLWASEPLPGEEPHPGCSKYESARFDQGFIVRHYAGRVEYRTDGWLEKNKDPLNDNLTRVLASSSERYVSSLFSEYGDAPSIVSGYVHALTVGKKRVTKKGAFRTVGQRHKEQLAGLMTQLQATQPHFVRCIVPNALKKPGRVDVPLVLDQLRCNGVLEGIRIARLGYPNRLPFVDFRQRYEVLTPGVIPRGYMDGRKACLRMVDALDLDKSMFRIGTSKIFFKAGVLAELEERRDALLFDVFSRLQAVARMFTARRQMKKVLNRAVAIRTIQRNARVYGELRDWPWWQLYTKVRPLLTATRNDDELHKKEAELALAKERAERDQKEKEALESLKMRLEAEKGKVEDELEAERALNLDKDSLLDRGKKREAELEDEVAALQADLDMLDSQLDRALKLQKESEEKHEALRLAFDQAAEHLVRLETEQQEWSAREAELAEYLDRARQQIDALNVAKDGLQKQDDDLKSLLAQREEDLSRTKDRMDVALSELDGKLSAELRNRDALRGKADSVEQEARQVKEQLSEMSRTATEYSNMIKRKEDDIVRLTSELESSKVERNRSLKEINELQVKVDTLTSELSAQQNDRTRRAAAQTKLQEELDELRSLLEAKTTEETRRGEVEKRKDQELLDLRSQVSKLSEELEENRRTTAEDQNKLKVDLDTIRREYDSLLASHKSLSERERSVQAQLRNAEASLSETDKSRRASESELQSIRSRQIDTDSQLADLQKAKEALERQLVTAHSRYADFEDAVLQLERDKGAHDRQLDVVKKQLEQESAKRTQLERQSSNQKAELVRLKDHNVKLDRDLNKALSDLKAREWEVKQLESKQDKTIVEHVHVLEEAKRVTDRQLADAQEELTKNAVYIRSLEKAKSRFMTEAEDLAREKEQEQVELRAKSKKIKAEEERAARAIADLEKERRAREAAELQLKRLQSALHMAEGQLSDVTTQLSTVQKARDSLDVELTRLADETVSSHSVQKLQRQYEVRIGQLEGQLEEETFAKTMAATIKEHVDRQHTKIRRLIMSSSPIDESFKSRLLEELRRTDEEMGRDLSNRSQQIRSNTGSTTRTMANIASSNRPTNGTARMRRESLPDSSRTPDKFAQINALRNQVQVLELQIAASNRVRQYLEVSLRDVTAELESSDGSKQSLDQCRIRLARENSRLAKLLEDEAEARRAAEAAQLNGVQAMWDKFQATIQEERDSNFRLEESRKALMVQQRATQVELEDHRHQVQELSLSKKQLQSQIADLTERLDAELVTKNDELASKRQLQLRLQELELTSSASSTIHNELQQAMETYKQLADSYLKKLDEAEIAKAKAARAESLARRALDDAEKGMSEAVAEARAVTERLQATEDHARDLEAKLDAEGLESSDLELLRQRLAEEMEDERKQHQQDLAERDFTADQTRKKYQAELAQLSEELQSQRDTMSRLREENRKLRSDHDELQLRYDDEVYNGGSWKKDKERLETKIQDLTKAYDASSAAQTEQQSQIVSLHSQVRELRGVLNDAEADRALLQKARRALQAELEAIKLDSVDTSKISSDTELQRLRLEKQDLQRSLEEQEDRVAMASERMKKAEGHTNECQVELGKLRVENSELDKFNASLEKQIKDLNVRIVDLETRSLNSPRPASTSRRHDSRVEELTNQLNQNSKDSSRFYRTADKNARDAKFQLAEADRQRVRLEEQVKSYETKLVGMRQAMDELQTSENNLQLEKRRTEREAADYKQKSLNLEREVERLRSRLERPSSAMLGSPVSSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRC5</accession>
    <name>A0A401GRC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615632.1">
        <property type="nucleotide sequence ID" value="XM_027759831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRC5"/>
    <dbReference type="GeneID" id="38781636"/>
    <dbReference type="InParanoid" id="A0A401GRC5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="467" mass="50541" checksum="D8AC8C00E4E23678" modified="2019-05-08" version="1">MAPNRLIEDLSARHNLPAMASDAEPPDTLDITMGESDEEDSIAEPRRPLISDLLDSPGSAQISLPLHSASQTPLAPRHTTPSLAAPFAPSNSSHEHLHRHASPKVQASSGSVAPVEGSRALIPDPLAPAWDESRGSLPIHRRALISDSTPTAPGGMFDFDTPGISPIPRRALLEATPLPPPAHTFDFRTPDTSQLPRRSLIAEPLDATPRTSIHFDSQASTPMARGMLVDETLDAEPVPKLLDFDNSPPATPGRRRALVIDSPGATPVRSQVRWLNSPSTSPPKRRPLLDDVLSPPPPPSAPSHSPARTFDDSNFRHDAPVIHYMKGSIEPVTVTSRMPSLAALPDELPIHRPTHWEQVPGLFPDTTQLLPMAVPGETNAASGSQVARLGRSFAQIAAEADSSMDDNEGDSFAVSRHRAMLQERIVRLQHELNLTEDMHVANLNASSTVFQMGYILRDIRGEAYRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRH6</accession>
    <name>A0A401GRH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615726.1">
        <property type="nucleotide sequence ID" value="XM_027759925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRH6"/>
    <dbReference type="GeneID" id="38781730"/>
    <dbReference type="InParanoid" id="A0A401GRH6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="11504" checksum="9B832A077DB9B9BB" modified="2019-05-08" version="1">MAAVRSDLAEHKLIGRPSATFNGSAFQRFSFVPGGNLPPAFRATEIRWYRAGIRRPSPFKSQVLWPDLEHATRCRNKIDPLAIRRKYSRRPRKRIPLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRN4</accession>
    <name>A0A401GRN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA-splicing factor cwf19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0700720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615805.1">
        <property type="nucleotide sequence ID" value="XM_027760004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRN4"/>
    <dbReference type="FunCoup" id="A0A401GRN4">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRN4"/>
    <dbReference type="GeneID" id="38781809"/>
    <dbReference type="InParanoid" id="A0A401GRN4"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="545"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="678"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE84892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="803" mass="90328" checksum="2D8866B4541E584B" modified="2019-05-08" version="1">MGHKDKDAKLVSNHESPRDKPHHEHKSKRKHKSDKDSGKAKRRRKDDEHVHIVDDDPNDDDMWVEKNIDMEGEEPLATTIPTAESMKLTSRAFVEPSDPPLPPSLKTESSLKRDEWMLMPPSAPTIPKERPSSRMSMPTGDESLTEDYGEPSQNARNTSGGVDFFSSLGTDIRKKKPEPDRPDPDKPKISNKELNTTLKEGGSLGDIPATAPKAFVPGGPGSQWRMMKLKRVYERAEEEGKSVEEVALDRFESLEAFLEAKEERRILDERSGRRASRNTDSKGKSRETEGERRFMFTDISGSGASSRSSSFRRPDVGNSIPSTPTLSGQGPGAASRRFDSLRLPSQGGTPRAQSHTPIPSVMTSSASIPGMKRALSPSSLNKLQAKVLRAKLVGASDAEALEKQYEQEVRKAHGEGEDGVRTRVELLPTLDARGRLYDVGLGKEDSPLPPGNRKKKEIVETRDPKTGDVIRINADDDSITLGEMLRQERFGAGMADQKNLDTEFARAIMSDGKYENDLDYIDDNAERLGRKKMRSDAMKRQFAINDYKRTQKVLATCPFCFGEDDSLPKAPVVAMGTRVYLSCTQYEELVQGHCLIVPIQHHLTMLEGDDDVWDEVRNFMKCLMRMFAEDDKGVVFYETVLSLKGQKHSFIECVPLPWAQFEQLPGYFKESILMSETEWSQHKKLIDFSARPGGFRRAMVANLPYFMVQFDHKGEKGYGHVIEGTSEAAGTGDDPEADIDEGEKGGGEFPRYFAGEIIGNILELEPRQWRHPRRIDFRQNKARVQKFKQKYERFDWTGMIGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRR2</accession>
    <name>A0A401GRR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615753.1">
        <property type="nucleotide sequence ID" value="XM_027759952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRR2"/>
    <dbReference type="GeneID" id="38781757"/>
    <dbReference type="InParanoid" id="A0A401GRR2"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="822" mass="91251" checksum="11487D40EF9AF792" modified="2019-05-08" version="1">MEEAEETEIPVNPVYLTLFSDHLNRVRGHLLGGDGPGSLPASFLEPNAYWTSAEKNAFFHGLTIYSRLRPDLIAAEIKTKTVVDVCVYLDMLEDGSAHNPHSSQRQDIPASREVSDRWLAFEEQQALALSNAEPILEEQALQKTRDDEFRTFRLATHARKGDGRTASNERDREGEKRRQKKYKAWFAERQEEWKGEDVLRALDTVAMKALNRILRKDEDVRWPTAPEPSGLHRAGKADDVQERAGSSTAIPFLPVEALHRIDEKMIDPVLRAQSQSTSVGDNFALPAAPMGTVAGVLPHAIYGAQFRPSTPPFQGTSITSDSLRQSVAPAHTVETSTSTVPGVEQALSPASRRRLQKRMHMRRKRAEKSGSVVSETVEKLKTGPKRKKRRGEAGASIVEHAGGGDVDPIERQHDKVAAARKGTDERDQQRADDDPSSSEDEDVKGSYRHPHPSGPTLPEKLRDKYKAMGITAERLYEEGLGLLHLGGLAKIMRLYNGLREQRDVPPSVASQISVDLVRILNAHVVKFTTQLVHRSIVSGEQERLAKMHTKVWGLKNKIISPVDVEHALSMMYSERPSKKAHFKGLLDRLDIAVESAAESDEEEDLVRGKGTKNDDSKGGKRERRPPASRSDDSSSPSQPEDNDSDADADDGRADAAQLIGPPHLSLHQTIFTPFVRLPSFTPLPSVGYSAPTDPSLFMPCPTSTLLFGTAEPPVDEELMPCVTRGDTLMAELLEDEELEKHDSMEDEQHEKRLWSKFASDSGEDEHDAHVSSKRKRIEDSSDVDEDNAQAKRDEAQAGGCQRYRQPDPNGPVKSRVYISDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRV5</accession>
    <name>A0A401GRV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0701400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615871.1">
        <property type="nucleotide sequence ID" value="XM_027760070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRV5"/>
    <dbReference type="STRING" id="139825.A0A401GRV5"/>
    <dbReference type="GeneID" id="38781875"/>
    <dbReference type="InParanoid" id="A0A401GRV5"/>
    <dbReference type="OrthoDB" id="192748at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14726" checksum="930CC93D46F949C5" modified="2019-05-08" version="1">MPSRTPPAGLLRSIINPSVVSAQTRRRLPLSARRNASDKPSQSWAELNSPVDPRPSWGSTVMKVANVAIIPMIILYATFVADFGEREHVFMPARRWLDGQKAAFFSLTPAEREAATVLNDTQQGDSPHTSERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS45</accession>
    <name>A0A401GS45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NAD-dependent protein deacetylase hst2-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0701630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615892.1">
        <property type="nucleotide sequence ID" value="XM_027760091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS45"/>
    <dbReference type="FunCoup" id="A0A401GS45">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS45"/>
    <dbReference type="GeneID" id="38781896"/>
    <dbReference type="InParanoid" id="A0A401GS45"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="12">
        <location>
            <begin position="15"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="309"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE84979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="529" mass="57764" checksum="7A14BC0BACCD0397" modified="2019-05-08" version="1">MGAQESYIKYEGPPDVLEARDIPSLVKYMQSDRCKNVFVMAGAGASTSAGIPDFRSPGTGLYSNLARLNLPFPEAVFDISFFRENPVPFYTLAKELLPGHFRPTITHSFVRLLHEHSLLRMCFTQNIDTLERRAGVPGRLLIEAHGSFANQHCINCHVAFDDDEMRECLLTGKIAHCDVCGGLIKPDIVFFGEALPDSFHASIPKLRTADLLFVIGTSLTVQPFASLATMIPDSCPRVLVNLDSVGDFGSRPDDVLCLGKCDDVVRDIARGLGWERELEKLWDETAASVEYPPEKPAVAPAAVPEEKEEKELEKEIEEITTKIEHVLNTQEEEKALEREKSEALSTGEKEPVIADKMRSNTGVSSETLAVESKAVPAAKAKPEAAVQTKAEPAAEAKAGSAVEERFRPTVEAEVKPVEVESEPAVEAKFNLTRAEKVEPEYEPAEEDTKLVIEPHAKLVVEPKAGPLAEGEVEPAVQVKIVNEPVVELVAEHTAHKADSALVAQEESLPVVDNEAGAGAESEMGLKEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSR2</accession>
    <name>A0A401GSR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ribosome biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0704680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616194.1">
        <property type="nucleotide sequence ID" value="XM_027760393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSR2"/>
    <dbReference type="FunCoup" id="A0A401GSR2">
        <property type="interactions" value="998"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSR2"/>
    <dbReference type="GeneID" id="38782198"/>
    <dbReference type="InParanoid" id="A0A401GSR2"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="74"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1110"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE85281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1155" mass="130711" checksum="00E20C0B976062AB" modified="2019-05-08" version="1">MEKQTHKAHRPAQSGAKADKKKGRAKEKQHGFNEKAFAPKSGRRADRQGRHKVEQDQTRLHVPLVNRTPDDHPPPVIVAIVGPPGVGKTTLIKSLIRRHTKQTLNHVQGPVTVVSGKKKRITFLECNNDLNSMIDVAKVADLVLLMIDGSYGFEMETFEFLNILQSHGFPKVIGVLTHLDLIKKAATLRATKKALKKRFWTEIYQGAKLFYLSGVLNGRYPDTEILNLSRFISVMKFRPLIFRNTHPYLLVDRLEDMTAREEIRQSKGKCDRSVTVYGYVHGTNLRPNTKVHIPGVGDLSMKSVAVLGDPCPLPDADSEKRRKLSEKKKLLVHAPMSDVGGVMYDKDAVYINIPGSFTRGNTDVLQGEGERMVMDLHDVESTLEDAVAKSQIRLFGSSSKPLVVGGSPSGHPNESEDKDASEDEEVDDEDWSISEDDEDDSVSLLDDEMQYGGSDAEGESTQQGDRGRSIMRNVHRSMRHLASHDRQGDKIDFAESDSDMGSYGGNEGERSKRVHFDGADDGNLDVPTDDELGEDSDADEVPQWKSNLDANAKNSYEQHSRKGRRKDWTRLIYQTSMTADEILHKSVSTSSADPSTGGLMTNEDFFTVVSMGPADIEEVDMTSDLTRLENLKEWEQEEVLDSIRNLFITGDLGKTQPSPGDDEDLILDDDGDLKVADSSNEQAGVNTESARSVALAAKKVALKRKFDEQYDDPESSKLDFYEEQKEQMSVQLELNRAAFEGVDLESRAMIEGYRPGCYVRIELLEVPCEMVENFDPSYPIIVGGLLPLEERFGYTQARVKRHRWSSKTLKTNDPLIISQGWRRFQTIPIYSLDDHSIRMRMLKYTPEHMHCYATFYGPIALPNTGFCAFNSLSGDVVGFRVSATGVVLDIDRSSKIVKKLKLTGVPFKIFKNTAFVKDMFGSALEVAKFEGANIRTVSGIRGQVKKALSKPDGAFRATFEDKVLMSDIIFLRAWYSIQPRKFYNPVTSLLLSEKREWVGMRLTGQIRREENIKTPLNANSTYKAIARPARRFNTLQVPKKLQAALPYSSKPKLIKQQHRKTYTQKRAVVMEPEERKTITLLQQIRALRKDQIVRRKEKQQERRTLHRKKVESEESKRSEKEREKRKEYMRIAGVRSKRESDTDFDDRGRKRPRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUZ8</accession>
    <name>A0A401GUZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0805340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616923.1">
        <property type="nucleotide sequence ID" value="XM_027761122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUZ8"/>
    <dbReference type="GeneID" id="38782927"/>
    <dbReference type="InParanoid" id="A0A401GUZ8"/>
    <dbReference type="OrthoDB" id="2795339at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="246" mass="27652" checksum="CBF964B498CEBECA" modified="2019-05-08" version="1">MAAPTVQARYPPSIDRPGTRRDDVVIPSISIAEPCTREQWLSMKDLPPMSSLPRVLVPNPKAVLRPPIMHYGWYANEEALLKHARHTRVGLTLPGTVSMLEIFLRIATGQRVEDVRHEDDDDRYDDRPQNLSNLQKIAMMQLALTDIVRTLDPSWPRGALMIMDTFTSDERFVVSLYTNHALEKAPSPEQIEALRVRLGESEPPKWYLDRTVWGWAPEGWPRGPASGPAGPSTLLPNNASDNTSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVQ6</accession>
    <name>A0A401GVQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0803660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616757.1">
        <property type="nucleotide sequence ID" value="XM_027760956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVQ6"/>
    <dbReference type="STRING" id="139825.A0A401GVQ6"/>
    <dbReference type="GeneID" id="38782761"/>
    <dbReference type="InParanoid" id="A0A401GVQ6"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021100">
        <property type="entry name" value="N-glycosylation_EOS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28147:SF1">
        <property type="entry name" value="N-GLYCOSYLATION PROTEIN EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12326">
        <property type="entry name" value="EOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="479" mass="51667" checksum="8BB38982EC57F244" modified="2019-05-08" version="1">MLPSVSTRVCCVPSFPLLAPCFPQSLHRQQPSLPALFLLPLSPAPGDPPHAPSPPRRSTSALALTPISAPPPPPPPLPPYPGCQPSPPHPLTRCRVRARPRRHSAMSAPSSSPPPYSLTPPEPSFSPASNRRAASSPHLRQPQYPLPSQRARRALVQSDCDDSADDTAASEDDILYTTSASASTGFTGVLRARILGKGKAREDTLRPITTAPGVRCAGETETDGEDSPRNLPTARITGPSLRPLPHTLSAVMPALVSFSRLLAIVPAVFGTVYLSACMLGLGGESDVWKAEFFVAALWAVLTGWQCLQMTTGLLKRWRVYYSPLATLIRLFALQAICWPATHLTLTLLDYEKRPALCWAVVGTTTCCSRSIQLWVTSNIAPAPLPHPPPPPALAASHSRPLHPSHAHAQHDSPLSALASALGNVIAGGAQDELEWKRGRRRRWDWAEVGRKCALPAGVLYFVTAWAEMIRREVERGPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVU2</accession>
    <name>A0A401GVU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme spm2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0901680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617202.1">
        <property type="nucleotide sequence ID" value="XM_027761401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVU2"/>
    <dbReference type="FunCoup" id="A0A401GVU2">
        <property type="interactions" value="830"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVU2"/>
    <dbReference type="GeneID" id="38783206"/>
    <dbReference type="InParanoid" id="A0A401GVU2"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="138" mass="15558" checksum="B7A997C9559EC228" modified="2019-05-08" version="1">MARVPRNFRLLEELEKGEKGIGDGSCSYGLEDGDDIMMSHWNGTIIGPGHTVHENRIYSLKITCGESYPDQPPTVQFVSRVNLPFVNQIDGKVDPHKLPVLAHWNRNSSIETVLVEIRREMASFNNRKLPQPPEGSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW78</accession>
    <name>A0A401GW78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein ERP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0902980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617332.1">
        <property type="nucleotide sequence ID" value="XM_027761531.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A401GW78"/>
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    <dbReference type="STRING" id="139825.A0A401GW78"/>
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    <dbReference type="OrthoDB" id="3427at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019249093" evidence="9">
        <location>
            <begin position="25"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE86419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="217" mass="25282" checksum="F51031023D3D8210" modified="2019-05-08" version="1">MAFTRRPRLLPICLLLCLAATVNALHFYLDTNEKRCFIEELPTDTVVEGHYKALEWSEKEQQYVVNPELGILVEVDEIESGHNVVRTRGPSDSRFTFTSHESGDHSICLSSNYGSSWFSSTHIRLYLDIVVGHTKADPEHDRSHVSELSSKLRDLNNKLEDIRREQQYQREREANFRDLSESTNTRAVWYSIAQIIVLVATCAWQLRHLKRFFEDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWF6</accession>
    <name>A0A401GWF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0904370</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617471.1">
        <property type="nucleotide sequence ID" value="XM_027761670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWF6"/>
    <dbReference type="FunCoup" id="A0A401GWF6">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWF6"/>
    <dbReference type="GeneID" id="38783475"/>
    <dbReference type="InParanoid" id="A0A401GWF6"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18435">
        <property type="entry name" value="BRCT_BRC1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
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        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 15 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="18">
        <location>
            <begin position="377"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="669"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="910"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="777"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="873"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE86558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1020" mass="116428" checksum="6C1CF79D412054A8" modified="2019-05-08" version="1">MLPTPAPSSPPSSPILGTQPAVTAEDHDIDYPVPPQNVDSAPFYVLSALFDKLQNERKPEKRRKLLNSWFNHWRAEKGFDLYPVLRLILPQKDRERAVYGLKEKNLAKTYIKIIPLGMRDPDAIRLLNWKRPTERDKVSGDFPTVLYEVISKRSSVIEGSLSIDEVNEALDQLSRNMGKHDIQTRVLQRIYNRSTPEEQRWIARIILKDMIISVKETTVFSVFHPDAHDLFNTCSDLKKIAWELWDPHRRLNEEDKAVQLFRAFAPMLCKRPTRKIEDSVKEMQGGTFIIEEKMDGERMQLHKRGNEYFYCSRKGKDYTYLYGKHVGTGSLTPFIDAAFDPRVDEIILDGEMLVWDPVVERNLPFGTLKTAALNKSKKDYNPRPCFKVFDLLYLNGLSLLHKSLKFRKRNLRACLAEVKGRIEYAVEFEGCTAKDVRDRMDEIMASRGEGLVLKHPESEYVLNGRNRDWIKVKPEYMDNMGETVDVLVVAGNYGTGRRSGGVSTLICAVLDDRRPPEDDEPKYSTFVRIGSGLSYADYIWMRQKPWKVWDEKNPPSFLQASSKGHEDKGDIYLEPEDSFIVKVKAAEIVSSELYHMGLTMRFPRALTIRDDLSIADCMTASAILEGVRSEKKRKMDTDDGKPKKKARRTAKKPALLREYQGGKMTDVKIESDLFEGMKFMVASDPKSQAGEQDKKELLTLIHANGGKYVHIANSDPNMLVVYGGTTTPYDIKLIMNKGICDIIKPRWITDCIAKKDLVPLRKKYFFHATEVRKLSEEYGMEDESEDEHIAVPIASPTPEASTAAEGKELEDVDPAMAEWFKVDEKLLEKQETATLDDGSETEPDSDNEDVRWNEDAVAEELDDDWFNVKSADAAEPTSQTASSSQGEENALQDDPKDSIQMGEDDSMEYDQYLIFKHLCFYLDSPANAKKHGMIVKSKHEDDIGRNFDSLSKILKENGGRVVDLDEPKLTHVVVDKRDTSRRVELIKRTSKPKRRNLVISEFIQACLDEGTLLDEDEFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWM3</accession>
    <name>A0A401GWM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0904790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617513.1">
        <property type="nucleotide sequence ID" value="XM_027761712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWM3"/>
    <dbReference type="GeneID" id="38783517"/>
    <dbReference type="InParanoid" id="A0A401GWM3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11461" checksum="883C397326B33AC4" modified="2019-05-08" version="1">MSIPASPTLINGVPSRAQTPFIRTSSPSPSIELSHASDEQEFATRLVSAIRVPVDFTDILVALRNRPQDRQAVVSMQRALEMVEWMQTARQELIAAEERTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWU9</accession>
    <name>A0A401GWU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G patch domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0905770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617610.1">
        <property type="nucleotide sequence ID" value="XM_027761809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWU9"/>
    <dbReference type="STRING" id="139825.A0A401GWU9"/>
    <dbReference type="GeneID" id="38783614"/>
    <dbReference type="InParanoid" id="A0A401GWU9"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="918" mass="100747" checksum="CF01A9D03DE7D93A" modified="2019-05-08" version="1">MTSRLKRKLNDLGVDPTSAKANESFCLIGTPLPPLEKSKDTGEFVPLWKQEVRDEKGRRRLHGAFTGGFSAGYFNTVGTKEGWAPSTFVSSRSDRAKQRLAKPEDFMDEEDLAELQESRKLVDEHDEMDFGGTEAELRRRTGANVDEEPDSISTALEASLAPAPKDSVGARILKKMGWRLGQGIGPRLTYAQRKAQDAGVLDSWKETTGEEENDEEAKKHMYPRRDTPVLLAPRKDNFHGLGYVPGMRLQEALGQEEAREKGPTLAAGFGLGALNDADEDDLDVYEGGRGRHGRTRMAYDAAHVDDDSHIIMGSSSARSRGQQSKVTTVASVQTFSDGRTVLKGFVLSDRPVAEDRWFALPEVPKGWTPNPRRVWDKNDHDENVDTARTAVKHPPKTHGDWKSSFISADQRGSMLGETPLPSQPRSVFEYMSQKDRERLQNIRNVISAPSAPSAATPSAAPPPSEHIRGQLDIPHLHPSIAKAALQGFQPFTADPVKQSRYTTFLNFQANREPADTGPVQLGIGPTQGQSIDDFNKELVDYAKAATVFKPLSAAMAGRFRSAVIVESGPTIIEGLHKPDFSTVKEEEGAKEEDEKKEEDPRMAAVRVGMYGPLTRDVQPWQPARLLCKRFGVKEPEVEMDSATAGPSTADFAPTASAKQADMTSAESSGAGAGAGAVSAGMITDGSSGEKREGGPRNLANVGLGEDDDQGRDTLTYQRPAMDIFKAIFASDDEESEAEAEDEGPDAAEEHDAGSVAPTEMQVKSEPVPVHLLLKDGPAPSYDTQQNGTASGSASQEKVDIASFKPTFIPRSDRESRADKGKGKHKQDKEKKKKTASKALMSFDVDDGMESKLGAPETRRHKDKDKDKDRERKKKKRKEHKEKDDDESMWVEKPPPEAAKVQRLQMEEKRALQEDGREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXY2</accession>
    <name>A0A401GXY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1003140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617980.1">
        <property type="nucleotide sequence ID" value="XM_027762179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXY2"/>
    <dbReference type="STRING" id="139825.A0A401GXY2"/>
    <dbReference type="GeneID" id="38783984"/>
    <dbReference type="InParanoid" id="A0A401GXY2"/>
    <dbReference type="OrthoDB" id="2804412at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="505" mass="56011" checksum="484EC50784DDE73A" modified="2019-05-08" version="1">MPRASASDVYAELLWSKDRGHPLWDPELAPGGEVRLGDVGFIREGAFHRLFNAYPHELWASAFGHTDQESEVNPFGVPEGFEPFSSRGRDNFGYRPRSPGLCHSRMSTDVTVTNLCRPSFGGMLPMIDTGVLSLEYNGNQHGAALLIEAGDSKFVKFTRRLSDYMKKNHDSWVLFANDTMDIDMASEDIVLVIGWGKTARWATVVMDEGAPPLIFTGAFGCPEAFRSSESAITHSNLKYKSGPRLAVDPPQSLDDPMWKHNQCIFVDYLKVRRRGLLKQVIKAAAKPRDSSNPRDNDSNVLESKQPFDPAGYVLDYILKHSEAEMAIASSLDIHMLCKDEEIPDNIPEFLEQVQPVIELTEDGLGILSLHKYMLHDLEISATIPPEGVPMSAVDVKGHDNTTGRQSALEEHQDGNLLLNHDDGGDYDTSTKEDIMTCGKGSSLVLQTEDNMDETPSHLPHMGLHLLQSVTCKSSLNYPVMTHHMFSADLQETHTLLPSQPTVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY18</accession>
    <name>A0A401GY18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1003270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617993.1">
        <property type="nucleotide sequence ID" value="XM_027762192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY18"/>
    <dbReference type="GeneID" id="38783997"/>
    <dbReference type="InParanoid" id="A0A401GY18"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19876" checksum="219CC9A7282FB48E" modified="2019-05-08" version="1">MPAEVWPLANGYLLSSYYFVPNVKKLISMILPHADREHRFRPGQMKEPELMQFLSVLAVPMPRLESRLVLPRNYDDLVLRVPHDHFPALRSVRLSPVCVPWTSLLLSGLTVLKLYYAEDFPTIDILLDMLAAKPELHIFTLELDSDFVGPSQSFSESVRVIQLPQLKRVSLVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ81</accession>
    <name>A0A401GZ81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclopropane fatty acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1101380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618375.1">
        <property type="nucleotide sequence ID" value="XM_027762574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ81"/>
    <dbReference type="STRING" id="139825.A0A401GZ81"/>
    <dbReference type="GeneID" id="38784379"/>
    <dbReference type="InParanoid" id="A0A401GZ81"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="453" mass="51839" checksum="FD54249DF9356811" modified="2019-05-08" version="1">MGAQSLTLLGSVRHSLWESLVQYMRGFMLRSLKNGLQHGHLVITEGENKHSFGVVGDRPISLSADIAVENEAFWVRVYLSHDLGFSEAYMHGDFTTSNLKAILDLWLANRDTLTSLMSMYSRVSWMISSIAVKNFGQTLVKSIPNVVTGYDCSNTFFQAILSKEMMYSCALWTDETGGVRGDLDGTVKKFDLENAQLHKIHYLLKKARVRPGDRLLEFGSGWGAMAIEAAKMGCTVDTLTLSIQQKILAEQRVAEAGLSDKVRVHFMDYRNLPPEFEKAFDAFISVEMLEAVGVAYMHQYFKILDWALKSDRATAVMTATSQPESRWTMYQATDYARKYQWPNTILPSATYLANACQEAVPRRFVLEGIEDNGVHYPRTLREWGRRLQENWTPEMITEMLKDRPELSNERDLAIYKRKWEYMCVYAEVGYARAYTSMHYWTFARPDNPMLVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZN4</accession>
    <name>A0A401GZN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1103040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618540.1">
        <property type="nucleotide sequence ID" value="XM_027762739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZN4"/>
    <dbReference type="STRING" id="139825.A0A401GZN4"/>
    <dbReference type="GeneID" id="38784544"/>
    <dbReference type="InParanoid" id="A0A401GZN4"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="16"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="321" mass="35368" checksum="2EE44D1B6AAFF513" modified="2019-05-08" version="1">MTNTFDKRRRRLKEIAESTLEAIEQGSFSLNNVTHDLNSRIVRAKKNTRYYAPDSLLSRWSSLSPPWRSPQTPTKVSLLETSTLEGARWLSATHSGNRPASDASAKIAILNFASAKKPGGGFKSGAQAQEESIARSSTLYPTLMTRTGQEFYTLHHRDQKGGYYSHAMIYSPGVTVFRDDGGGWVEPLDVDVLTSAAVNAGVARHTLHGRVAGPAVEGKIEKAMRERMARILYLFESNRATSIVLGSFGTGVFRNNVAVVANIWADLLLSDGARFKDSFDHVAFAILGKPTFEEFQKVFEDRRKSGPDGSDSADQSKFEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZN7</accession>
    <name>A0A401GZN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fimbrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1103120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618548.1">
        <property type="nucleotide sequence ID" value="XM_027762747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZN7"/>
    <dbReference type="FunCoup" id="A0A401GZN7">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZN7"/>
    <dbReference type="GeneID" id="38784552"/>
    <dbReference type="InParanoid" id="A0A401GZN7"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110009">
        <property type="term" value="P:formin-nucleated actin cable organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21294">
        <property type="entry name" value="CH_FIMB_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21300">
        <property type="entry name" value="CH_FIMB_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000016">
        <property type="entry name" value="Probable fimbrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF18">
        <property type="entry name" value="FI19014P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="113"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="261"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="388"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="537"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="650" mass="72385" checksum="2A1689647487ADC9" modified="2019-05-08" version="1">MDALRLRKKYPEVSQDEMFDFINRFNTISTNTPGRIDKTDVLQALQANGESYDRARETLKHVSVDASGKLELEDWVELNVKLRSQAPSSGLQTKAGKVTVHGSNANVSHTINEDERAEFTNHINLVLDGDADVGSRIPIPTNTMQLFDEVRDGLILCKLINDSVPDTIDMRVLNKPAPRKPLNAFQMTENNNIVITSAKAIGCSVVNIGSSDIAEGREHLILGLIWQVIRRGLLAQVDIKLHPELYRLCEDGETIDDLLRLTPDQILLRWFNYHLKQAGWNRRVNNFSRDVSDAENYTVLLNQLKPDLCSRAPLQTRDVRARAEQVLHNADAIGCRKYLTVGSLVAGNPRLNLAFVANLFNNYPGLEPLDEQEAKDYGVVEDFDAEGEREARVFMLWLNSLGVEPGVFNLFENLKDGLVILQAFDKVLPGSVVWRRVSKPKAGFQASNSYSAGGTGEEEEDIGVTPNQSNLSRFKQVENCNYAVDLARQNGMHMVGIQGADITDGTKTLVLGLVWQLMRMNITKTLSSLSKSGQGRPISDTEILKWANSTAQKSRPGVKPIRSFKDPSLTTGLFFLDLLEALRPGIVDPTLVIGVSDHGDYEERRQNAKLAISIARKMNTLIFLVPEDIVDVRPRLLMTFVGSLMAIANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0G2</accession>
    <name>A0A401H0G2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1201430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618830.1">
        <property type="nucleotide sequence ID" value="XM_027763029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0G2"/>
    <dbReference type="STRING" id="139825.A0A401H0G2"/>
    <dbReference type="GeneID" id="38784834"/>
    <dbReference type="InParanoid" id="A0A401H0G2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="38010" checksum="A29ADB0193A1D15C" modified="2019-05-08" version="1">MDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIANVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETLKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0R6</accession>
    <name>A0A401H0R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1202280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618915.1">
        <property type="nucleotide sequence ID" value="XM_027763114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0R6"/>
    <dbReference type="FunCoup" id="A0A401H0R6">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0R6"/>
    <dbReference type="GeneID" id="38784919"/>
    <dbReference type="InParanoid" id="A0A401H0R6"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="283"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="635" mass="69923" checksum="8BAD74066AC8A4C3" modified="2019-05-08" version="1">MKDVHITSNHTASLKQDLDNVWGLIILVIGRVCFRLPLAIRSRSSTSPAQQAHKNFPDREGSVVEGAQSHQTYRRVQDGIISALLQSRARGTYLHNAHLPPGSWSTICDPSKSASCLHDGTLLAGQSTSHAHSDRTPSCELYAVDQLSFWPSEPPPKQMLPGLLPLCLLLALGEVGRATAQQCKLVLQQDLQITNPKTQTPGISTQIPSPTSTRPVSTASPSSTSNITTFTPFNYGAEKVRGVNLGGWFVLEPWITPSIFQGTNNTNVIDEYTFGQLMGADYAQETLRTHWETWITEVDFQNIRAAGLNHVRIPLGYWSVPITSAYTNYSTSVLPYTTGAWPYFLQALGWARNNSLHTIVDLHGAPGSQNGFDNSGQRGSPGWANGSDTVGRTLDIIKFIADQVGDMADVIELLNEPAGWVSDIGSAISGYWQDGYQVVRQAAGSGPQVMIEDAFLGIQTWENFMKYPNASGVIMDEHQYQIFNDDQLALSLSEHLSSSCQTLSQYASFAKSNMYTVMGEWSNAVTDCAEWLNGRGVGARWDGSIAEGQQVYGSCDGWTGSMSTFSDEYKAFLRQYWESQVLIGESVQGWVYWTWKAENADEWSYQKGLEGGWIPQDPTDLMYPNMCSSANFTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0R7</accession>
    <name>A0A401H0R7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1202540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618939.1">
        <property type="nucleotide sequence ID" value="XM_027763138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0R7"/>
    <dbReference type="STRING" id="139825.A0A401H0R7"/>
    <dbReference type="GeneID" id="38784943"/>
    <dbReference type="InParanoid" id="A0A401H0R7"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="386"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="615"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="777" mass="84298" checksum="F4B55C4D3C072A48" modified="2019-05-08" version="1">MSFLAPSQRGYDSLTHSDLGQLSSMHTHSSRIPMHTFSSYDNLTLHDVPSTSSSSGPPSSHVSDRSAVASPRTGQTRCYWTLLTPDLTFLYLDPVFSSHLQEQADLLVGKSLLAFVHPDEQASAKLDLGSVLESRTLHGSVTRVRYSRLSRVRRQLGYHGPLQEWADADKIAVDADYMAVDIVINWASDGLVLCFMHAVVDLTPRDSDEHNKTGWSNWCGTPSMSTEQVQLLYQRLLAAVPQPPNVSRVFQILLNQPDRALYMSWPPDQNQGGPTAKDFARLAQDVQISNAISSGTDAKTNCTRRYKALQVMQCGMDGNREVESIFILHGALIFACHKVNAVLRSGPSGGVQSNYSSQSYTSPSVPYYDPPTHSYSLPPVPAPPSYNGYYGSQPRVPQTQYSGSWSPSSEPQNGQYNQWPPQGGMSPATTVSSLRSSSYPTPQQHQWSSQPPSYMDSNSVPPSFNQPLTSSNLRYSADSANNHHEGPSPSPANDHVPPSRTPRRGSGNSREQYGNGGRSSGNPPVGISKCSSCDATQSPEWRKGPTGKKDLCNACGLRYARSRAKKESGGVSSQGRRRKDRAFSTMSDKPSASPSTSPIDVPFASVRRANLYDDSSFSSTASPSGSEICSQHHGSFNGMTPSPSPPSASMSYGGYSHHHSAPSSQNSQADHRSHMGTHNTFYSVPPPLPNGAVHHMAGSSHSGPPIPRLEPLMSFPSRFSPMLSPSSPGSGSPLSAGLSAASFEREKHDKDHERTLLPPTPVSADVRHSDKQGFMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0T0</accession>
    <name>A0A401H0T0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618916.1">
        <property type="nucleotide sequence ID" value="XM_027763115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0T0"/>
    <dbReference type="GeneID" id="38784920"/>
    <dbReference type="InParanoid" id="A0A401H0T0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="86" mass="9835" checksum="C4BF9F69F9C51A13" modified="2019-05-08" version="1">MFQRPSSQLSRPRTRERAVTQRRLHLTGRLKVGSLSRLFSKCTLSMHIKSTCMNFLLWSGLAVKKRRPGISGLLAVQAYRVSLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0W6</accession>
    <name>A0A401H0W6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618943.1">
        <property type="nucleotide sequence ID" value="XM_027763142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0W6"/>
    <dbReference type="STRING" id="139825.A0A401H0W6"/>
    <dbReference type="GeneID" id="38784947"/>
    <dbReference type="InParanoid" id="A0A401H0W6"/>
    <dbReference type="OrthoDB" id="3253876at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="334" mass="36312" checksum="A8C62ACDCEA56B8E" modified="2019-05-08" version="1">MYSPRRTYGSPPPELSNNPFIDHPSNALARFPDISGSNDLSGDSSQFAPWAQPSGSSLVSSTTGYAAQGAPAGYSNGYQQQPPMQLQPQQTSWNGGGGFAQPQQQGYVSQAPQISSPFQPSSSFGQQLAGQVNSTYTGMPQQQPQMQQQYSGYQTPQYGGAYQSGFPPQPNNQYLPEFDPYAQLQSTPFVATPSGGGNGQYRQLHPREYVQQHKAELEAWDGYAWKQIQNAFDALKEAWSARKRDVESRVRAMGGAGLFGGGGVYGGQAQEYARLESLTREAESNFDSVAASAFQMQEVYSGYRQSGDLASKRRVRESINAALSSLPDWPPQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3W8</accession>
    <name>A0A401H3W8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1501400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620048.1">
        <property type="nucleotide sequence ID" value="XM_027764247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3W8"/>
    <dbReference type="STRING" id="139825.A0A401H3W8"/>
    <dbReference type="GeneID" id="38786052"/>
    <dbReference type="InParanoid" id="A0A401H3W8"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000608">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="15">
        <location>
            <begin position="130"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="13">
        <location>
            <begin position="264"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="13">
        <location>
            <begin position="376"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="14">
        <location>
            <begin position="456"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE89135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="754" mass="84176" checksum="D6DCDC3283AF2040" modified="2019-05-08" version="1">MVFKDTVLQQQFVIVRLVKAIVGSQADHELLKPKSPYVPRKHTTREPEREVVSGVPPESKNTIPYVVKLPRAEIPNRISSALSKGSSANIITFFRQSVLPSTLDNKTHGQHFKALIWAEEHRTELDLAIYDINGTQLNRHNRYYYLAVPGLAEKRPSVLVGDLIMVHPHDSLEGKWYEGYVHVVHREEVGLCLNGSYRGHSESQRYNIRFKLNRIPLRRQHQALDTAFYPDRILFPLVAHVSTGNPPSVATMKAGIHNKLIANNPAQLQAVTSIVYHPAGAPPFVVFGPPGTGKTITIVEAIMQLINHNPQARILACAPSNSAADLIASRLINKLSNAELFRFYAPSRFKDQVPDALLTYSYRTASGHHSVPPVATLKRYRVIVSTCVSAGFTYGVGMPRGHFSHIFVDEAGQATEPEVMIAVKTMADNSTNVVLSGDPKQLGPIIRSPIARELGLEVSYLERLMQREPYDEQAGYGKSVVKLVQNFRSHENILRFPNERFYHGDLRPCGDAGVINSFIGSSILVSKNFPIIVHAISGRDLREASSPSFFNIDEVTQVKEYVQLLRADRRVRITDADIGVIAPYHAQCQKIRAVLRPIADGVKVGSVEEFQGQERRVIIISTVRSSREFVKYDLKHTLGFVANPRRFNVAVTRAQALLIVVGDPSVLSLDPLWRSFLNYAHINGGWRGNAPSWDTLAPVETGSDFSGQVRESRLANMDDFARRMEALTLEGVADGVLQDDDLDVNVDRPWREVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H425</accession>
    <name>A0A401H425_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1501580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620064.1">
        <property type="nucleotide sequence ID" value="XM_027764263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H425"/>
    <dbReference type="STRING" id="139825.A0A401H425"/>
    <dbReference type="GeneID" id="38786068"/>
    <dbReference type="InParanoid" id="A0A401H425"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018820919" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE89151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="490" mass="53482" checksum="50F9637115CA2E33" modified="2019-05-08" version="1">MLIMPVVAFLATLPVLSVLGGQVPMIDGVLGGVPAFRASYAEVKEKVASAVPTRVTGPLRVTENSGICETTPDVYQASGYGNISSSESMWFWFFEARNNPDTAPLTIWLNGGPGSSSMIGLFQEHGPCRITNDSSSVTLNPYSWNEVSNMIYVDQPIGTGFSYGTTNVRTSQEAADDIWTFLQIFFADSRFSKYQKNEFALWTESYGGHYGPAFAAYFLEQNAGIADGSVTGVLINLKYLGVGDGITDPLSQYPGYIEYAGSNPYHPLVSSSVIGTGNQSWTSRHGCKAQIEACYDNGSDDTCANAQQYCNDNILEPLAGNYDVYYVLSQNPDPYPPDLTPYLSNSTLLALIGADSQWQEDSNEVYNNFACTGDWMRNSRPDLETVINSGVRTIVYDGDADYIMNFMGVEAMVANLQTEFSSQFAQQQFTSWTVAGQAAGIYKNAGMFSYVRIFGAGHEVAAYEYGTLSRGQAALQMFSQIMSNQSLFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H434</accession>
    <name>A0A401H434_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump vrtL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1501130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620023.1">
        <property type="nucleotide sequence ID" value="XM_027764222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H434"/>
    <dbReference type="FunCoup" id="A0A401H434">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H434"/>
    <dbReference type="GeneID" id="38786027"/>
    <dbReference type="InParanoid" id="A0A401H434"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="530" mass="57791" checksum="628E752FC6A2C458" modified="2019-05-08" version="1">MASPFNTSTLPLAEDSQSIDQKKQGDSNRCSNVLLEKRAADANTVEDNPETIIVDWDGPDDPANPRNWSKRRKWAAALTVSAFTFISPVSSSMVAPAANQIAAEFHITSSVEIAMTISVFVLAYAVGPLFLGPLSEMYGRVLILRGSNLFFIAWNLACGFSQNKAQLIAFRFLSGLGGSAPLATGGAVLSDMWTPDQRGQAIAIYSLAPLLGPVIGPVAGGWIAQLSTWRWVFRSTSIAAAVVQLFGYFFLRETNAPLLLARKAKQIKKELDIEKGSRTVRTVYQTEDRRWKRLFAKSLFRPFILFAQEPIIQLLGIYLAFVYGTVYLVLTTIPDIFQFTYHEKAGVAGLQYISLGIGLSIASQTNARMLDRVYRRLKERNGGVGLPEFRLPNVMPGTLLLPIGLLIAGWGAEKHVHWILPDIGFAFIGAGTILIFQGIQTYVIDAFTAHAASALAAVSCLRSLAGFGFPLFAPAMYKALGYGVGDTILAAFALAVGFPAIWLFWKYGARIRGMSKHARQDEKPAQGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H473</accession>
    <name>A0A401H473_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620116.1">
        <property type="nucleotide sequence ID" value="XM_027764315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H473"/>
    <dbReference type="GeneID" id="38786120"/>
    <dbReference type="InParanoid" id="A0A401H473"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="62" mass="6940" checksum="33189CD324488E8E" modified="2019-05-08" version="1">MLTRSRSPPCSSSAPPSSRTHEEQNLKLTLLNMSPAARYAAKATMVHVPRLLRLPSTFAWLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4B3</accession>
    <name>A0A401H4B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1502620</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620167.1">
        <property type="nucleotide sequence ID" value="XM_027764366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4B3"/>
    <dbReference type="FunCoup" id="A0A401H4B3">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4B3"/>
    <dbReference type="GeneID" id="38786171"/>
    <dbReference type="InParanoid" id="A0A401H4B3"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000965">
        <property type="entry name" value="Autophagy-like protein 18 Atg18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE89254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="423" mass="46104" checksum="4C0D91DC29267C10" modified="2019-05-08" version="1">MVERVNSNMLFANFNQDFTCISVGTRKGYSIINCDPFGRVYTMNDGARGIVEMLFCTSLIALVGAADFPQSSPRKLQIVNTKRQSMICELLFPSSILAVKMNRKTLVIVLKLEIYIYDISNMRLLHVIETTPNEEAIVALSPSSDNSYLAYPSPVPSPTSPLAQPSVQPSSPPPANQQTGDVLLFSTRSLSVANVIQAHKSPISFLSINSTGTLLATASDKGTVIRVWSIPGAEKLYQFRRGTREARIYSISFNLVSTLLAVSSAHDTVHIFKLGQQQKSGTSSSKSVPSPSSPSESLDSREGSQGLDGGYEAYVDKKKTGSVSSALRRRSMHLTKNLTSSVGGYLPNTLTEMWEPSRDFAFLRLPTSGARCIVALSGTMPQVMVISSEGYFYSYNIDLENGGECSLLKQYSLLDPNDESAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4C6</accession>
    <name>A0A401H4C6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1502590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620164.1">
        <property type="nucleotide sequence ID" value="XM_027764363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4C6"/>
    <dbReference type="STRING" id="139825.A0A401H4C6"/>
    <dbReference type="GeneID" id="38786168"/>
    <dbReference type="InParanoid" id="A0A401H4C6"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035098">
        <property type="term" value="C:ESC/E(Z) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046976">
        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="211" mass="23295" checksum="810EA486289C7303" modified="2019-05-08" version="1">MINLRSLPQMNHALTRDHAMHNVLAHETKRTVHGNAVVAETVQDDGVDAAVHAASICELERVTLIAVHVAAPTTSMSITAEILKFRRADKRFGVKHSDFGLGVFLMQSAKEGDLIAEYIGELIYEATFDSRGQLSNHRGRSYVFGIDPSLSNDSTYAGNTTRFINHAPEKKANCIVGIRIVHGDHRIGIYAKKSLAKGAELFLDYGPEFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4U5</accession>
    <name>A0A401H4U5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1601060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620357.1">
        <property type="nucleotide sequence ID" value="XM_027764556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4U5"/>
    <dbReference type="FunCoup" id="A0A401H4U5">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4U5"/>
    <dbReference type="GeneID" id="38786361"/>
    <dbReference type="InParanoid" id="A0A401H4U5"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="240" mass="26392" checksum="01C0F94B77550634" modified="2019-05-08" version="1">MASRIAISSLKASAPRVRPQVAAAIPRAVQSRGMASKPPPAERASEIINKLPSSPNLITRTGTAILGTGLLATAISNELYVVNEESVILVGFAVLVAFIAKSIRDPYRDWAEGHIQRIKGVLEKSRTEHTQAVKDRIESVEQMKDVVSITQGLFALSKETAQLESEAFVQRQKVALAAEVKTVLDSWVRFEQQEKENEQAELARAIIDNVLKSIKDEKTQRDILTNVVTEVEQLVKSKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5R3</accession>
    <name>A0A401H5R3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620667.1">
        <property type="nucleotide sequence ID" value="XM_027764866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5R3"/>
    <dbReference type="GeneID" id="38786671"/>
    <dbReference type="InParanoid" id="A0A401H5R3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="140" mass="15516" checksum="855C87BB723F2F7B" modified="2019-05-08" version="1">MRRGWRRKQPPCEPESASNAKGGHHDDDDGGQRNDDNISASQLNSDTDVKGEDDPDVRPKDRRDGKKVAKAAKTRRGWKRKQPPREPESASNMRGGGRAPAKKPRVAGSVAGEKRLTQAATLPRKSTRIAIPTKRKRFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H688</accession>
    <name>A0A401H688_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620816.1">
        <property type="nucleotide sequence ID" value="XM_027765015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H688"/>
    <dbReference type="GeneID" id="38786820"/>
    <dbReference type="InParanoid" id="A0A401H688"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="312" mass="34458" checksum="52A6C8488A44F2DD" modified="2019-05-08" version="1">MFDFDTPGISPIPRRALLEATPLPPPAHTFDFRTPDTSQLPRRLLITEPLDATPHTSIHFDSQASMPMARGMLVDETLDAEPVPKLLDFDNSPPATPGRRRALVIDSPGTTPVRSQVQWLNSPSASPPKRQPLLDDVLSPPPPPSAPSHSPARTFDDSNFRHDAPVIHYMKGSIEPVTVTSRMPSLAALPDELPIHRPTHWEQVPGLFPDTTQLLPMAVPGETNAASGSQVARFGRSFVQIAAEADSSMDDDEGDSFAVSRRRAMLWERIVRLQRELNLTEDMHVANLNASSTVFQMGYILRDIRGEAYRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6P9</accession>
    <name>A0A401H6P9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_1800750</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620966.1">
        <property type="nucleotide sequence ID" value="XM_027765165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6P9"/>
    <dbReference type="FunCoup" id="A0A401H6P9">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6P9"/>
    <dbReference type="GeneID" id="38786970"/>
    <dbReference type="InParanoid" id="A0A401H6P9"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="18">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE90053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="650" mass="73371" checksum="FC5F990FDA27DFA8" modified="2019-05-08" version="1">MPRYDDWNKIEEDEEDELQDTYYEGKKDVILFCIDCSPSMLELHEDTKYEDMQTCHLFTALEAAVQIQKKKVIVGPNDAVGIMLFNTTRKNDPKGQGAEIKRGSFVYQPIDTISAETVQELMRLLDAAREDPNVLRETFPPKTDGRIPMGDVFTSCNWVIRDGAPKTATKRVFLITDEDDPHEGSTNERLMTTARTTLIDLVQAGVNLEPFFISTAEKPFDVSKFYSSVLLPSNLVDDEESDATVLPESISITRIEDLLSQMRFHEVPKRALFSIPFQLAKGFVIGVKGYGLVTEQKKGAYKYFVDVGGSMELANPHTLYVDEERQTEADKTRMFFGMDLGAPAATEDADEDAEEESGVGARVVPVNSRPFYTADEVRSFRTMGLEPGLKLLGFKDRRELAFEDNIKHSTFIYPDEMTYSGSKRTFSALLRTMLKKKKIALVLSLTRRNSSPTFGMLLPQAEKIEEGGWNEPPGFHLIPLPFADDIRAAPVEQSFRASDELKDAARQWIDKLSVKNGAYPPDSYPNPALAYHNAQLEASAFREEFDAEGFEDLTLPKCDMIHKRAGQLMKEWKRLLLHDESANTVIVTTGSKRKADISVDEAEIRSKHEVNMLGKLRVDQLKEFLKSKSQPTSGKKAELVERVSDWLDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4R4</accession>
    <name>A0A401G4R4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608062.1">
        <property type="nucleotide sequence ID" value="XM_027752261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4R4"/>
    <dbReference type="GeneID" id="38774066"/>
    <dbReference type="InParanoid" id="A0A401G4R4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="207" mass="22128" checksum="A89E55F5192A77DD" modified="2019-05-08" version="1">MQKHIAVRPRANSERPPDLQLGESTPPCVRQTARAIVRMRALSSEAKRAVARLTPCARARARMGVLTSDAAHRADGASNRRSVGAVSLAGVRPARIQGPDEERSAERASPPFPQNHTRGSRTDGGAGGGSRTVCTTGAEPRRPRRWASAPGMLALRTARRRGGACDARSRAAATLCPRSRAMLAVNRGRFSHLDGCVAAGLRRSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4V5</accession>
    <name>A0A401G4V5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0100670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608108.1">
        <property type="nucleotide sequence ID" value="XM_027752307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4V5"/>
    <dbReference type="GeneID" id="38774112"/>
    <dbReference type="InParanoid" id="A0A401G4V5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7554" checksum="1A46C7E04F009D83" modified="2019-05-08" version="1">MFVACAVKSGHIIDPHCHHGIDYVIGVALAVITLYRPARLFARRSLKACPHPSSYPEIRSRSIISGLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5J1</accession>
    <name>A0A401G5J1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdopterin cofactor biosynthesis C (MoaC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0103060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608344.1">
        <property type="nucleotide sequence ID" value="XM_027752543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5J1"/>
    <dbReference type="STRING" id="139825.A0A401G5J1"/>
    <dbReference type="GeneID" id="38774348"/>
    <dbReference type="InParanoid" id="A0A401G5J1"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin cofactor biosynthesis C (MoaC)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="201" mass="21193" checksum="FC51C023B44F35E2" modified="2019-05-08" version="1">MVDVSAKEATKRTAVAIGRIYIPEIAYELVTSTYLPSADKVCGTPSLTESPSEIVKAKARSKGDVLSVAQLAAIMGCKRTADLIPLCHPLQLSHISVTLHPEVRHCPSPVPMDIADSLNAVASSAVSRSTLGSEVKYSILCCAEVSCEGKTGVEMEALTAVSVGLLTVWDMLKAVAGKEMVIGDVFVSRKEGGKGGDFTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G642</accession>
    <name>A0A401G642_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0105130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608546.1">
        <property type="nucleotide sequence ID" value="XM_027752745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G642"/>
    <dbReference type="STRING" id="139825.A0A401G642"/>
    <dbReference type="GeneID" id="38774550"/>
    <dbReference type="InParanoid" id="A0A401G642"/>
    <dbReference type="OrthoDB" id="205569at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="502" mass="53482" checksum="350B84639E4B75C9" modified="2019-05-08" version="1">MAKNKNLNPADAFRKAQRKKELKKNKTERSKARDFALVKKDTGELEEEIGKLEGTSAQQSASDKARLAELKTELEKITKKKQDYVAEHPEHRKLVFRSRKTQNDHEEKEDEIPIQKTRKLFDKHGLPRHPERSIYYDPVMNSYGVPPPGMPYVERPLRPDEVASDEEDGSGEDEDIVMPEGPPPGASEDQDDSDDDIPMPEGPPPPKAGVAPLPPTLPPHIVPPTAFPAGTSPPPPPGFSVGFPPPPASLPSIPHPPLPGALPPLPPGFPVLPSGLPLFQLPPPPSGFPNGPPVGISSIPPPPPGFPTLLPPPPGFAQNQFHPPPPGFPPPPLGFFPRRSQSASAKQDPLSSIPHQTYQAHRASRLATPAHPSLPPNPSLPSASSSIAAAATVSAAPELRNLKKESTAFVPTALKRKKAGAVSAAAPKINAAPSLGPTAGSDEVEVAPAARRPDLLSTLQDQFGSAAAQKSQASGKGGREKPKDDYEKFVEEMDDILGPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G665</accession>
    <name>A0A401G665_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0105370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608569.1">
        <property type="nucleotide sequence ID" value="XM_027752768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G665"/>
    <dbReference type="STRING" id="139825.A0A401G665"/>
    <dbReference type="GeneID" id="38774573"/>
    <dbReference type="InParanoid" id="A0A401G665"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="269" mass="30110" checksum="0D73FE98673A34B1" modified="2019-05-08" version="1">MQITYMDADLNTYGFPSGYFLIRSVPTNRVFDVTEGFVADSTEVILWPETETSMVEGIRDPGSNNQVFFVDGTGHLCSRSSGHALDIQHDRVVIRHRRPIVHPYPNAFSHPLPRFSYDSETKHISVQFAVDPSYHASPDEAATASAWKDRTFLLTSIPLRQPHSLIDDASAFFSSALASPLSFFGALQTGPSAKAEEIFSSGDIDLREDEILEQDRTEEGEVDDSLDKYRKVRVVAVSKEDVKAVGQQARSRMQWEVIPLRTGRNRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6M5</accession>
    <name>A0A401G6M5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0106950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608726.1">
        <property type="nucleotide sequence ID" value="XM_027752925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6M5"/>
    <dbReference type="STRING" id="139825.A0A401G6M5"/>
    <dbReference type="GeneID" id="38774730"/>
    <dbReference type="InParanoid" id="A0A401G6M5"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019175834" description="cellulase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="8">
        <location>
            <begin position="54"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="334" mass="36267" checksum="06855A4D04E2DA46" modified="2019-05-08" version="1">MKYATALLAAASAALAQQFPIRLGGVNTAGYDFTVTTNGSFSGTGATPPSYEYAHFSSEGANLYRIPFAWQLMTPTLGGAINESFFEQYDTTVQYALNSSTDSYIIVDLHNYARWDGGIIAQGGPTNEQYASIWTQLAEKYGTNDRLIFGLMNEPHDLDIPTWVDSVQYVVSAIRGTGATNYLLLPGSNYTSAQTFPTGAGPLLAEVTDPLYGNTDKLIFDVHKYLDYDNSGTHAECVTNNTVVMEDLVTFLLQYGGRQAILSETGGGNTASCEEYLYEELAYVKSAYPNMVGFSVWAAGAFDTTYILTVTPNANGTDQPLWIDAVRPNLPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6S6</accession>
    <name>A0A401G6S6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0107450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608776.1">
        <property type="nucleotide sequence ID" value="XM_027752975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6S6"/>
    <dbReference type="FunCoup" id="A0A401G6S6">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6S6"/>
    <dbReference type="GeneID" id="38774780"/>
    <dbReference type="InParanoid" id="A0A401G6S6"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="321"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="781" mass="87774" checksum="D50288D77504A3BD" modified="2019-05-08" version="1">MLSQGSTKVFKDRPGERLSARSHGTHSAIPTTQRMDILISSNGALFLLPDPVTCFRAAKYNQLQVFHLHNAASIVLLDWVTSGRKSIGEEWVFSMYYSLNEVWVDGERLAKDVMFLQEQDDVQSLPRRTLANTLAPYSCYATLILYGATVQSSLRHLAAEFEAITVFKHSSPPDLIWSFSLIREGKGCVVRVAARETEDVKHWLGGTTFRTGRQTFRRSIYPPGHSKVILSAFSKVSVWTWLGTWRTPHEYKVRGLACSHAGRVASRIRPMSVETSSKKDVSDLDPEVQISDQSPVNLYRPDVDTSGIDERKLLRRIDWHVVPWLAVLYLLNFLDRGSIGNAKLYNMTRDLHISDTQYLIALTSFFFPYALFEPPSNVLLRRSRPSLWLSSLILIWSIIMTLHGVVQNYGGLVSLRVLLGLAEAGLYPGIVFYLSCWYKRNEIGTRVAMFFTSATVAGAFSGLLAAAISNMDGIGGKPGWAWIFILEGLFTFVCAIASFFILQDFPENAKFLSETERVWVIRRLRDDMQFSAGGEKFKFKFVKQSLTDWKTWIAMGIYMGYDGPLFAFSLFTPTIISQVGFKATAANLLSVPVYAWACLVTIFVGFMGDRYVKRAYVNLALFTIGLVGYIILISSSTPALSYVAVYLATTAIYPSVPNSVAWVSNNVEGSYKRSVTLGMAIGWGNLNGAVSSNVYRSANKPWYRMGHGIMLAYIVIGWVCTLMFFLLLRRENARRDAGERDELIDGVDNKRANAEKNGHFSSVEEARREKGDDWSGFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6T1</accession>
    <name>A0A401G6T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Mitochondrial respiratory chain complexes assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0107460</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608777.1">
        <property type="nucleotide sequence ID" value="XM_027752976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6T1"/>
    <dbReference type="FunCoup" id="A0A401G6T1">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6T1"/>
    <dbReference type="GeneID" id="38774781"/>
    <dbReference type="InParanoid" id="A0A401G6T1"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="335"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="753"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE77864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="797" mass="87762" checksum="3AFDB358EA02B6C0" modified="2019-05-08" version="1">MIPRSLRAASLPRGRIAYISRVRWARTFATPSDHPPPSEKKSGEQKSESKDKGEPQDKGKVVEEASKDAADQKEPMKGLEGFFQRYHRQQQQQQQQEQKGAAEKEPDSGRREQDSKQKPPPPPSDGGNGFNANQLALLATTAAIFYALSNSSTASSREITWQEFRTAFLDKGLVDKLVVVNRTKVRVKLHSNATGTMYPSAPLGGGDYYFSIGSVEAFERKLDEAQKELGIPSHERIPVAYHEEVSAFSYLLNFGPTLLFAGLLFYLSRRAGAGGGGGGGVFNFGKSRAKLFNKDTEIKVKFKDVAGMDEAKQEIMEFVSFLKEPAKYEKLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFFSVSGSEFIEMFVGVGSSRVRDLFASAKKNAPSIIFIDEIDAIGKSRGGRRGFGGNDERENTLNQLLVEMDGFGTQEHVVVLAGTNRPDVLDPALMRPGRFDRNITIDRPDVSGRKAIFLVHLRPLKLSKELPETEAFAHKLAVLTPGFSGADIANVCNEAALHAARHAHESITEFDFESAIERVIVGLERKSRILSPEEKKTVAYHEAGHAVCGWFLEHADPLLKVSIIPRGVGALGYAQYLPADRYLLSTPQMRDRICMTLGGRVSEEIFFGPENITTGAQDDLQKITRIAFEAVANYGMNDVVGPVSYGGAKESGESWQKPFSEKTGEMLDLEVRKMITAAHQRTTELLTKHRENVEKVAKLLLEKEVITREDMITLLGPRPFANRKDEMDKWLDENRNERSAPPPLESANEESPAPAPAAVRHDDPNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6T6</accession>
    <name>A0A401G6T6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0107550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608786.1">
        <property type="nucleotide sequence ID" value="XM_027752985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6T6"/>
    <dbReference type="STRING" id="139825.A0A401G6T6"/>
    <dbReference type="GeneID" id="38774790"/>
    <dbReference type="InParanoid" id="A0A401G6T6"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="21"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="526" mass="58234" checksum="8CBBC3FA8B31D975" modified="2019-05-08" version="1">MEAPTPRSRRRLVGQPLLYAISVFASLGVFLFGYDQGVMSGVITGPHFRKFFNNPGPIEVGTMVAVLEIGAFITSVAAGRVGDMLGRRGTLFIGAIVFAVGGAVQTFTPGFWIMVVGRVIAGFGVGLLSTIVPIYQSEISPPDHRGALACMEFTGNIFGYASSVWIDYFCSFINSDLSWRVPLFIQCVIGALLALGSLLMPESPRWLIDTDKDVEGMQVIVDLHGGDPHDVVANEEFREIKDSVVFERESGEGRTYAMMWKRYKRRVLLAMSAQAFAQLNGINVISYYAPRVFEEAGWIGRDAILMTGINAIIYLLSTLPPWYLVDRVGRRFILLTGAVVMGIALGFTGWWMYIDVPETPRAVVACVIIFNAAFGYSWGPIPWAFPPEILPLTVRAKGVSISTATNWAFNFLVGETTPWLQEQIAWRLYPMHGFFCACSFVLVYFLYPETKGVPLEEMDAVFGEEELEERLEEEESERASLVSRRSSRSRAHVRVKSNSQGPSLLSRLFGGSGGPSNYEPIRDGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G753</accession>
    <name>A0A401G753_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)H-dependent FMN reductase LOT6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0108770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608908.1">
        <property type="nucleotide sequence ID" value="XM_027753107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G753"/>
    <dbReference type="FunCoup" id="A0A401G753">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G753"/>
    <dbReference type="GeneID" id="38774912"/>
    <dbReference type="InParanoid" id="A0A401G753"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050712">
        <property type="entry name" value="NAD(P)H-dep_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543">
        <property type="entry name" value="CHROMATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30543:SF21">
        <property type="entry name" value="NAD(P)H-DEPENDENT FMN REDUCTASE LOT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADPH-dependent FMN reductase-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="212" mass="23197" checksum="A4DF8B7682AE8A08" modified="2019-05-08" version="1">MSKIALILGSSRTPSNGRGIASWLTSVLKSRFNNSPTPNADMEKKVNNLYRVCFVDPTVSPLPLGPIVDGSYMPSDIHNPDKYPSPAVQQWSTFVSSCAGFVVLSPQYNWGYPGELKNVFDHLYWEWRGKPVMLVTYGGHGGNKSATLLREVLGGGLKMKVLSKSVEITLPSAYIKGEEWVTGAHVPEFIAKHESSVGEALEEMLQLLSAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G774</accession>
    <name>A0A401G774_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vesicular-fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0108800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608911.1">
        <property type="nucleotide sequence ID" value="XM_027753110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G774"/>
    <dbReference type="FunCoup" id="A0A401G774">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G774"/>
    <dbReference type="GeneID" id="38774915"/>
    <dbReference type="InParanoid" id="A0A401G774"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="289" mass="32331" checksum="4C09BFC7868F5C48" modified="2019-05-08" version="1">MPSKSPAQTLLEKADKKANSSTGWFSSSSTKFEEAGDLFQQAANAFKIDKLFKEAGDAHSREAECREKCQETNEAANAWWNAAKAYKRGYPDLAIQALTHTITHLTQGGRFRQAADREKEIGQIYLQEVNDLRKACESFERAGEWYAQEDATATANACYKDAADLHADLDEFPQAIARYEQVADGSLSSALTRYSVKEYWLRSSLCALAMADTVTAKRNLIKYTSLDTTFSSTREAKFVNILIEALEAGDNEAFTAAVFEYDQVTKLDNWKTNILLKIKRSIQEEPGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G789</accession>
    <name>A0A401G789_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0109170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608948.1">
        <property type="nucleotide sequence ID" value="XM_027753147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G789"/>
    <dbReference type="STRING" id="139825.A0A401G789"/>
    <dbReference type="GeneID" id="38774952"/>
    <dbReference type="InParanoid" id="A0A401G789"/>
    <dbReference type="OrthoDB" id="3253083at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="413" mass="44978" checksum="D943F79ED296BB1D" modified="2019-05-08" version="1">MSTSPAPSASRGDITLQPSYFTSSLYVGPLREDISRLIYAFSEQYVGPQQPCQPFALFKKLWTDLGWSWIHFKVFDARARETFIDVTERLFLERMADTEPPLARVIALFALYTFYSTQPSTSTPALRCSKYLDVPIDAYTSIITLPSTLIEPGLHPLQPYVIHLLTTLIDSQAFHILPRSELRPFNPSVLPREIFVQDGEEPTALTGLTSDETASSFARPQKKKGRPSRREKAKKAKDALVALEKYVEKNSVPSSGSGLLQSGMQSAWSTPVPSQVTHTLLTHPPTTTRNNYRAHKMQLLDVLDPYTGAPSSSTGAVEGTATWKALEKANEALLARLREIDALAAEKGLEVGGEGGEKTGLARVEKAAKELHERSGASPWARGGILGLLEGAGLDFSEEGDVGGSGEMDGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7G9</accession>
    <name>A0A401G7G9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Breast carcinoma amplified sequence 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0109970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609028.1">
        <property type="nucleotide sequence ID" value="XM_027753227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7G9"/>
    <dbReference type="FunCoup" id="A0A401G7G9">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7G9"/>
    <dbReference type="GeneID" id="38775032"/>
    <dbReference type="InParanoid" id="A0A401G7G9"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="137"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="218" mass="24830" checksum="90C6CD994E1C7FF1" modified="2019-05-08" version="1">MTSEIEQPQSSLIFDSLPYYDNDLEQQPALRERVERELARDAKPLQTLHPRVPPSPKLFANYPLLDAELSRLESRQPLPALDTTRYQLPGPSSTPAGEEEWKTALANAHSQLEHQRLRHANQALLQSYGANAWRIHNYRVEASAKNIEKALEDLKNLTTEVNRERKNFQTQIGDQLTSLETRWTELISNILQIEMANVALEAEVDRLNKTEAQLAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7H0</accession>
    <name>A0A401G7H0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0109980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609029.1">
        <property type="nucleotide sequence ID" value="XM_027753228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7H0"/>
    <dbReference type="STRING" id="139825.A0A401G7H0"/>
    <dbReference type="GeneID" id="38775033"/>
    <dbReference type="InParanoid" id="A0A401G7H0"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004733">
        <property type="entry name" value="PRK06074.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6 11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="93"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="272" mass="30905" checksum="69DA24FFF086BE2E" modified="2019-05-08" version="1">MSLRLVSSAGRLLRNSSVRPLVAGGAQLSRGLHFSQSSKASASPFTEQTSPNPTITKYAETTEALHTYGSYLIQCLPKYIQQFSVLKDELTLYICPSGVIPVLTFLRDHSQCQFKSCMDISGVDFPERSKRFEVVYNLLSVQLGGRIRVKTYAGETDAVPSALPVYKGADWYEREVWDLFGVFFRDHPDLRRILTDYGFEGHPLRKDFPLTGYTELRYDEEQKRVVYEPLQLTQAFRNFDSLSPWEQVGQGTTPKRPEDLKPVPPPKPEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G891</accession>
    <name>A0A401G891_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0112760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609304.1">
        <property type="nucleotide sequence ID" value="XM_027753503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G891"/>
    <dbReference type="FunCoup" id="A0A401G891">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G891"/>
    <dbReference type="GeneID" id="38775308"/>
    <dbReference type="InParanoid" id="A0A401G891"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000016">
        <property type="entry name" value="Polyubiquitin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="381"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="457" mass="51268" checksum="201521BFAB1A78B0" modified="2019-05-08" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8G9</accession>
    <name>A0A401G8G9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0113530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609377.1">
        <property type="nucleotide sequence ID" value="XM_027753576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8G9"/>
    <dbReference type="STRING" id="139825.A0A401G8G9"/>
    <dbReference type="GeneID" id="38775381"/>
    <dbReference type="InParanoid" id="A0A401G8G9"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="558" mass="63110" checksum="04172E3FC10C5B95" modified="2019-05-08" version="1">MTDKKKAAQLKEEGNALYVKQEYHAAAEKYSKALEYDSDNAVLYANRAACALGIKDYPHASVDAQKATEIDPTYAKAWARLATARAALGTIIESIECWNKALSTLPRTNLSPAQSRQKEQYEAELRKIRAQEHDAPAVGIVMKEGGKEAPWVRAKAMLPKLRSLGYAMVQSSAWVISAAYDVAQFEVTTYLFLTLPFFQDFAQGVELMKSIKKSPTPAGIMYSGPPGAIEALTNGIMRDSRAFHIADNNWLEMYNIQVMVNCQRFQAWTGDSSQVIAEALRRQRKKGWDDVRPAISTTVRAWIMRALIADKIQQKSDDALKFYDWILDVLQWGRRVWKSVPKDDRGSVFESTFVRGVRSLRLESLMEACSKNPRPDSKYTLEDLFEEAQDLIREIDIAMTNIPTVEYDPGFISSFYIYPRAHAYAMIGFYHNKMAKQCAELGVTSLGDVMIHFAEASKAYLTAATIFPEDDENHVWYLNCALDALYSCGTPIKILLPIMERVRLAIPKMKEIWEFSALAHQGRDSILQKVLWGEEDMRKGLADGKFTLEDKVMPELQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8U2</accession>
    <name>A0A401G8U2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Guanine nucleotide-binding protein alpha-2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0114660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609490.1">
        <property type="nucleotide sequence ID" value="XM_027753689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8U2"/>
    <dbReference type="STRING" id="139825.A0A401G8U2"/>
    <dbReference type="GeneID" id="38775494"/>
    <dbReference type="InParanoid" id="A0A401G8U2"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000469">
        <property type="entry name" value="Gprotein_alpha_12/13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00440">
        <property type="entry name" value="GPROTEINA12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="381" mass="43750" checksum="4C4C2C5F753ECF8D" modified="2019-05-08" version="1">MGACLSSESVEVSDEEKRLHRQAEKSLKEAKAKMAKQVKVLLLGSGDSGKSTVLKQMRLIHRVPFSTQEVESFRQLVFNNLTQGIKYLLDSMEDMGLEVSEENRSYLSLVDDAADLRDGEPFPPAYYEPLKRLWEDPSVQKAWDRGNEAAIPDNLLYYFSDLGRLFEPTYVPSEQDIVRARVRTIGITETVFHLHDHELLMVDVGGQKSERRKWIHCFQDVTSILFLVSLSGYDQCLIEDKDANQMQDAMTIWDSICHSQWFKQTSIILFLNKNDLFEQKVKHSDIKNFFPDFDGEPGDAHAGRDYFKKRFAKLAQKANAREREIYIHVTTATDTVMLKVVMAAVEGKSILSQHEFQSNSIFFRHNSSAKPYYSSNDLILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G961</accession>
    <name>A0A401G961_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0115890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609611.1">
        <property type="nucleotide sequence ID" value="XM_027753810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G961"/>
    <dbReference type="GeneID" id="38775615"/>
    <dbReference type="InParanoid" id="A0A401G961"/>
    <dbReference type="OrthoDB" id="3205170at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="16018" checksum="62527B9A1054B274" modified="2019-05-08" version="1">MRSDHRSHRRIARYKAELSTRPKRANSDATTSSTGSGSDMSAFGDMDVEPPVIEYQPDDLDEPLSWAFQDGDPVWVKTEEGEWLQGTVNGKSTRRGATRQKEGVFFPVSFRISSRKYFAPLNGDVKPDTPEVRRLLLEGGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9B9</accession>
    <name>A0A401G9B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0116240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609646.1">
        <property type="nucleotide sequence ID" value="XM_027753845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9B9"/>
    <dbReference type="STRING" id="139825.A0A401G9B9"/>
    <dbReference type="GeneID" id="38775650"/>
    <dbReference type="InParanoid" id="A0A401G9B9"/>
    <dbReference type="OrthoDB" id="2796784at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="418" mass="45387" checksum="F385AC5A0C1B9A9C" modified="2019-05-08" version="1">MSLVAGLDYRGKASMRERLEAVWGAEGGRGEGPDHATPAVALQGPNSPSDSSNGGSRPRDISNTAPALCDFVQAEAALQVCAEGLGPGRNARRQYYFEKRTAARATARAKKKKASAMHVQSTASLSQRKMPGGYIGSRIKSERPPRREIIGCANGAAAYICDSEGRLVIYRSFAGPATVRANSAAMAAVEYLQHSGVKPTYSGSTRGNFLQYYFTLHRDNQVRPRMSLYYLKHIDVVRELGNLLKPVVALINGIFKSRFPDLYAHYAATLDYVLEKDAGLEALFYPFASFALNAGIVVTLPHLDSTNYGPGLCCIMPYGTFDPAQDCRIGIAELGYEIEVGPGVPVFIPSAMFTHYNTILISKGMRGSLVFWTGGSIFQWVELGGKMVSELSGPEHEVYIKGLAARILAGLARFPMHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9T6</accession>
    <name>A0A401G9T6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0201270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609843.1">
        <property type="nucleotide sequence ID" value="XM_027754042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9T6"/>
    <dbReference type="STRING" id="139825.A0A401G9T6"/>
    <dbReference type="GeneID" id="38775847"/>
    <dbReference type="InParanoid" id="A0A401G9T6"/>
    <dbReference type="OrthoDB" id="3267267at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58587" checksum="B924E77ADB47A9B5" modified="2019-05-08" version="1">MVVDRSATTGSGSKDALPPDTTIVTSVQGVARTHMALSNVLEQRKHRALTPYNANAWESQLCTAGLLGRYKNLPDGLRVGFRINIPQITRTQDPPNKESIVTFAPEFLKIVNAEIAKGRYIGPFSRTDLEHLIGPFQSSPLSIIPKPGQPGRFRIVQNYSFPHTPSLRFPNPSINSTIDSDLFPSTWGTFNAICLLIRRLPPGSQAAMRDVAKAYRTIPLHYSQWPGSVVRTNKRELCLDTCTCFGVSPSSGVYGYLADAGTDLFRSHGMSPLSKWVDDHLFVRVLCEHLAWYNQQRQIWHTGLSQWGRHHNGGRIWYGGRRFEDGTLEEFDEDCTFPCRDLSAQSPRSEDDAKYTYNFADINELSKELGIPWECSKDVPFATTAVFTGLVWDLEHITVSLSTEKKEKYLRAIHDWQEQTMHTLNDVQKIYGKLLHACLVVPRGRAYLTTLETMLGTCHDRPFVHYSPVKGISADLQWWSTLLQSAVLTRPIPGPVQLTDLGAFSDASSGIGIAIVINGQWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAC5</accession>
    <name>A0A401GAC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HRQ family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0203190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610035.1">
        <property type="nucleotide sequence ID" value="XM_027754234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAC5"/>
    <dbReference type="STRING" id="139825.A0A401GAC5"/>
    <dbReference type="GeneID" id="38776039"/>
    <dbReference type="InParanoid" id="A0A401GAC5"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="51858" checksum="3CAD286684EE9C4E" modified="2019-05-08" version="1">MTFADPQMGNILAICFLLVAAAVVAYLTRVTRKVSQVNIKVKGCGDSEKTEREAGEWTPVVFDYPKIEPFTGDLSAVKPIPYRPFRWGDYHVTMGIRNMPWNEWIELDQQFFDYHKIREYRLRTRADRSVIIHPEQPGIVQSGHAGAEEFLYELAEYLPRRYPTIYRVERHATSKPNSYSWYGENPIKSITIIPLQITYDLDEEDPLTMAARLVQEDFAIMIEGTDGRYYLQGGAILIPGFWRLKDKVGMPLDQIHVSGDVPQYQSKLHLSMGRFFRRLPVDKPVIRNNYGFQVVKNTDPTATTEDPTRAVDPTELAWSASMQGNEDRTDYERSAHVRTEHADGKVRSWTELLPSMVHLRTERQTLRRLPRTGAVVFTIRVYQTPIDSLAQEPGAPGRLASAIRSWPDDVADYKDRFAYEDILQYLDKRHAEQIEAGEITGEERISYYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAF6</accession>
    <name>A0A401GAF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0203260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610042.1">
        <property type="nucleotide sequence ID" value="XM_027754241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAF6"/>
    <dbReference type="STRING" id="139825.A0A401GAF6"/>
    <dbReference type="GeneID" id="38776046"/>
    <dbReference type="InParanoid" id="A0A401GAF6"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1166" mass="126024" checksum="A3379BD749276267" modified="2019-05-08" version="1">MPKPTLIQSLLGRPSQTYSFPQQKEYHSSKHELIRIATTRTECHEAPGASLLPGLPPTSSVSPSVLSEHVSAQVVPNSDVHSPPRTFQGSTRSVHFQKERTTDSDLLPKRSLIRQIASFHTAPPAQHGHTSYLNPLQYFRTDRHQVDFTRTAELALDGDAAEDDMFYTPRSSTYSSPRASRSSTLLLLDSHALANALLPLHSAAAPPELDTTVATPVSRTPSDSSLSSHASSSTDHDEAGSSFSSSCATTSTRITTPLSSDHGALKPGEDVVETVAISTSPQRSPSPHRSAPSPSPINQPAQQPEEAVQSTTTTASQTVSLVSDSPARSESPVRLRPLSISSLPSCNNMEGDAMATRRRSQVEARMTMYTDEDWANEVKMSTAKMTSTNTSSPRRMSRPLHPDLLPPIPTGSPTGTSHFLEPPTTFPQATPRPGARSRSKADRSSRHSHRQSRGRMSALWEEDESEYSTAPSSCEPSRAPTPVHFTESLSSLTPSSTAPSSPGPLHPLFLSNTNPMDKYMLSDEQSQLDESPDAMLQDYARLRGQLRSRPSSPVRSPLVPSESSTMSSSLPTYSIPTPFPGSVSNSPPTGYTSLTLPRANYANETGKAMRDGKVDLVRAGVAQSSMATIEVVRGASLAVRSRPGNRRGFSLTLSFGLKGKKPERRRSVNRKESMTPAHLRSTLPLPVAFTSHLPPPSFCPPSHVLVQVFAVALDGLDSLLVQEKIDDGSGGASAGSLRKGRAGFIPGRSFVGRAMECGFEVKDEVCKRGEWVVGLLDVRKCGALAEFILVERHRVFRSPQPCARPITLFPPRRRKHTRSMSLPSQQHPTFTPSPLVPPAPLSLEELALLPLIGLSAHRAVRSFADVLSTPRTRDLESRPRMLILQGHDGPGCLALQLLARKGVRVSVQVPESAVCDILESSTEGTSQDESRIERVETRIRDWGAEEVCVGTPVEVLQRFADECRSFDAVLDTVGGVAIWEAAQRMLLLSPSAATARHASKSSPAFSVLQAHPDAPEKTSKFSPSQAQFTTLVGDTPNRAIPKAQDNLKSGFRSLRRAITTSSQGKTAPIKVLNDGKKSVKRTVGYTWVSVAADVDFEGEDVRDTLAAVVAMVEEGVMRPWAGLGDPEDQDTKVLPLERAPEVFRRDAAGPLGVLKDGGTCVVKISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAL6</accession>
    <name>A0A401GAL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0204050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610121.1">
        <property type="nucleotide sequence ID" value="XM_027754320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAL6"/>
    <dbReference type="GeneID" id="38776125"/>
    <dbReference type="InParanoid" id="A0A401GAL6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7556" checksum="E4BB8F28F8294A22" modified="2019-05-08" version="1">MLSHLFSNACFYAEMRRAPAPGGAITDYPVLEASTLILNFEVSSSFLPGLRWQVAQMSASIIMHLVLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAV7</accession>
    <name>A0A401GAV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0204870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610202.1">
        <property type="nucleotide sequence ID" value="XM_027754401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAV7"/>
    <dbReference type="STRING" id="139825.A0A401GAV7"/>
    <dbReference type="GeneID" id="38776206"/>
    <dbReference type="InParanoid" id="A0A401GAV7"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46502:SF2">
        <property type="entry name" value="16 KDA PHLOEM PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46502">
        <property type="entry name" value="C2 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="718" mass="77517" checksum="3EEDAFD3ED6F7121" modified="2019-05-08" version="1">MTSTPRDVGTLIVVVLKAKNLPNKRHIGKQDPFCTVTYNGEKRRTKAIHRGGQHPEWDEEIRFTLFEDTENDATNAANGGTPPPPPPKANGKGPPKIKGGKSMIISCYAEDPREPDLIGETTVDLTEVLTKGETDEWFTIMNKEKYCGEVYLELTFWSNEPPPVKKVRAKPKAHRQYGGPGSFVPTEESTEEVRHAISHLPSTSSFREELSRDSIPSSLRSSSSIANLDLYVPAYESTRSHHSVDSVVNEFAELGFSDNVNRRQSFPPQQGYLPTHGSFIEYPDSQALSPLSSQGYRHSTYSDGGYSYERPVTPSGSLPYHHSSMSINHEPYQAPYESTPPPQPSYQAPVRHAGPRYSMPTSSSGFMPVSTPAPSGFLPLSSHVSQPSGFTPLPAPTPAPMGYGPPPSHVPVPSSSFSTLPLSLVPPPSFGVVPSASPAPYHQHTLPQPPPGHSYPQYPPPMPSSSFQHYPLPALTTSAPPLSQTAPQKAYGPPAPVSVPVQSQSAPPPDRQSMQMSIPPPPHDHIPPPPPLNESPSSGQVSNSRPLPQPRRRNSSLPVPPMAYPQYVPTAGGNVHMPPSVSYNHIPPPPPLPQHSAAASTYSQTPHPTIPVPPPPAPSSVQSRPTRRPSLPAPPHSDYQQQSQSAFQALPPPPPPPTLPAHAIYEQVMPFPVPSQSQTFYPGPPPRPPVQLQSQSQYLPPTGGPPSAHAGYSSPLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB22</accession>
    <name>A0A401GB22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0205470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610262.1">
        <property type="nucleotide sequence ID" value="XM_027754461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB22"/>
    <dbReference type="STRING" id="139825.A0A401GB22"/>
    <dbReference type="GeneID" id="38776266"/>
    <dbReference type="InParanoid" id="A0A401GB22"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="750"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="572"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="972" mass="108457" checksum="C695412848AAD462" modified="2019-05-08" version="1">MNSIHDPHVHKRTSITELLNPVAVPSAPPLDPAAYSSTQLPGLSSFLPPAHSQHVHPHSYPQPINTSAPSAAFSLRAASWDQATKDNNMPSTMRRQDSDPASCRYSSSSSVPPHHPIYHQDPFSRPARQLEETPNYGMDVQNWPTSSDQANTSYPPLISPMYSDERTALSGDSVPKNYPPQQYDQDMVAQQYAANGYFPVMLTDPASRGSMPPSVPSQRGQPTPPAYFPPHMNVAFAAIPFGPPPPTAQKRPMESPGEDGAPQPKVKKTRTKAKPDGTASRRGYNAKKRSEAAQIAAQNAHLMPTVSYAHVSDDKGKEKATDNNTSALGSTMRIVADDGQPHPESSGPLHPELQFARCMSNRYRSEEFPRCVSCTRRWAGDTCRFQGIRFFLKNESNQIVGISFVESQKPDSPTMHFPVKWNIPLQPSHLRRLKRTVAQALLPTLQQELKHLNLAEIIRRPRESEVRATCDTCMTSIFSTSWMCRLCGREACAECYEQVRELTTDRVGAPEAEVAALQARREKHAHVNPFFLSCTRRNEHQAKDFSPMSRFCKAELSQAITEMEALLAESDPDALPAEGSPANGSTPASLSGEASSGWSAPAKPANGSDSAFPAPPVNVAIPPDPSTFAPNGTLAAPQATNGSPTIPSHETLYYTEVELSDDTFRRVWAKGEPLVVTNLLPKFHVQWTPEYFSTKYGTQSCLILECQTDQNKRVTVGEFFSWFGKYEGRRDCWKLKDWPPSTDFRTAFPELFDDFSQATPVPNYVRRDGVLNLASHFPSNTVAPDLGPKMYNAMASFEAQGSKGSTRLHMDMADAINIMLYANTTPDGRPGCAVWDLYKAEDSIKLRKFLRKRFKGQFQHDPIHSQLFYLDSTLRQELYQEYGVKSYRIYQKPGEAVFIPAGCAHQVCNLADCIKVASDFVSPENIERCELLTREFREQNQSMAWKEDVLQLRTMMWFAWLSCRRQERDADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBT2</accession>
    <name>A0A401GBT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">26S proteasome regulatory subunit rpn11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0208340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610547.1">
        <property type="nucleotide sequence ID" value="XM_027754746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBT2"/>
    <dbReference type="FunCoup" id="A0A401GBT2">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBT2"/>
    <dbReference type="GeneID" id="38776551"/>
    <dbReference type="InParanoid" id="A0A401GBT2"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="29"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE79634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="34232" checksum="3B3C9F6FDA345F33" modified="2019-05-08" version="1">METDIEQMLAQAGGRQGQESTVPDNGEVIHISSLALLKMLKHGRAGVPMEVMGLMLGEFVDEFTVQVIDVFAMPQSGTSVSVESVDHVFQQKMVDMLKQTGRSEMVVGWYHSHPGFGCWLSSVDINTQQSFESLDPRSVAVVIDPIQSVKGKVVIDAFRLINPAAVLQGQEPRQTTSNIGHINKPSIQALIHGLNRHYYSIAVKYRKTELEQSMLMNLHKRNWTEGLTLRDFKTHKESNEKAIKSMLTLSEAYNKSVQEESTLTPDQLKTRHVGKQDPKRHLEAEVERAMGDQVVQNLGTMLLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBT6</accession>
    <name>A0A401GBT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0208110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610524.1">
        <property type="nucleotide sequence ID" value="XM_027754723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBT6"/>
    <dbReference type="SMR" id="A0A401GBT6"/>
    <dbReference type="FunCoup" id="A0A401GBT6">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBT6"/>
    <dbReference type="GeneID" id="38776528"/>
    <dbReference type="InParanoid" id="A0A401GBT6"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="67"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="289"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="496" mass="53415" checksum="C8FFBB309A7771D2" modified="2019-05-08" version="1">MSPVAASKSAIRRLINAAQHTACPCHGCRAGGSHNPMHAISQVRKFASPVDAPPVEKEYAFEVAASNLRFGEGVTREVGMDLKNMKARKVAVFTDPIIAKLPPAKMAIASLEAQIDLPFEVYDRVVCEPTEASWRDAIAWSRQHDCSHFLAVGGGSVMDTAKAANLFTVYKDADLFDFINAPIGKGLPIDRQLRPLIAVPTTAGTGSETTGTAILDITSMSFKTGIANRAMKPALGIVDTLNTRTCSRELHISTGLDVLFHSLESYTAIPYNERTPRPSNPILRPAYQGSNPVADIFSMWALHTTVKNLPRISKNLDDHEAMRQMMLAASFAGIGFGNAGVHLCHGISYPISGLNKQGPKYKFTGYNVDHPIIPHGISVALPAPAVFQFTAPSSPSRHREALAIFHGTTPSDPTISAIPDVEIGAHLYEAIARFLDNLGVPRGLKAVGYTKADVGKLVDGTIPQRRVLDLAPGIGDVAGADGREHLTRIIENSFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD46</accession>
    <name>A0A401GD46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0213120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611022.1">
        <property type="nucleotide sequence ID" value="XM_027755221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD46"/>
    <dbReference type="STRING" id="139825.A0A401GD46"/>
    <dbReference type="GeneID" id="38777026"/>
    <dbReference type="InParanoid" id="A0A401GD46"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37372" checksum="5CA0E6176E9F62C4" modified="2019-05-08" version="1">MLIHNVARRCCSTTFKRSYASVSSSSSPINPNTVRPFQVFDRNAKRLQKDRAASREDGVRSRIVDYVRDEVADRMIERLLDIKRKFNTILDLGSGPGHFSRLLEYETTNKVVMLESSEKLLHRDPDTEFDVEVKRIYADEEDLLKVVEPNSQEAIVSCLSLHWVNDLPGILIQIKEALQPDGVFMAALFGGDTLFELRTALQLAEVEREGGISPHVSPMTDSRDMSNLLGRAGFTLLTVDVDEVKVAYPSMWELMDDLRDMGESNAVIGRRNFIHRDTLTAASAIYKELHGHENGSVPATFQIIYVIGWKPAPTQPKPLERGTGRTSLKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD57</accession>
    <name>A0A401GD57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0213190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611029.1">
        <property type="nucleotide sequence ID" value="XM_027755228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD57"/>
    <dbReference type="GeneID" id="38777033"/>
    <dbReference type="InParanoid" id="A0A401GD57"/>
    <dbReference type="OrthoDB" id="2795196at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="131" mass="14020" checksum="C6AE6725C499F3E8" modified="2019-05-08" version="1">MSASSSAKTLSPPPAYSEFAESAQHQPYIPSRDATNVVLSASSGSQSHAGYGPTPIAQYTHLLPYYDLRSPYALAEAGSRARWRFVGAMVWAVAILLLAGFVTGYEVHLKIHHALLGGQSTSGDTDIWQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDB9</accession>
    <name>A0A401GDB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0213840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611087.1">
        <property type="nucleotide sequence ID" value="XM_027755286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDB9"/>
    <dbReference type="STRING" id="139825.A0A401GDB9"/>
    <dbReference type="GeneID" id="38777091"/>
    <dbReference type="InParanoid" id="A0A401GDB9"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109:SF3">
        <property type="entry name" value="RING FINGER PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="38"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="396" mass="44106" checksum="5DB266C48A5A058D" modified="2019-05-08" version="1">MDHQSHPDNGYDINKAHDGNGNAEASGSIAPPTLEIHIRRALKGAQALQEELATLQKRNGALQRRLDVLEQDGQVDVQPRRGRGARPTVSGLQVQVQELKDQIKKLEKDKKKDKRKIEKLKLKEVKEDAVDLQEAAFEVGDTAYRMRKLLRRFHDLMLSPSLEEGEECPVCMESLVPTKCASLPCDHTFCADCIQQLSPGKDDLTCPQCRKVWPRDEPEAIQYTASQQWDALLDVAKDWACMDHRREDDTSEEEAEEEFIDDGIPDATSSEVSAPHDQDPLATSPEPEVEPKPQELDFEPGVRASPKRRRAVTLESSPEPDDAVAPEAIAAVPETQHNGTTLNDASTSNDAGASKQERPATPPNVATPLYAQSPNSEKRKRMEDLAARRSSKRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDH2</accession>
    <name>A0A401GDH2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0213690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611076.1">
        <property type="nucleotide sequence ID" value="XM_027755275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDH2"/>
    <dbReference type="STRING" id="139825.A0A401GDH2"/>
    <dbReference type="GeneID" id="38777080"/>
    <dbReference type="InParanoid" id="A0A401GDH2"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="3">
        <location>
            <begin position="6"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="37187" checksum="1AC69693C1D01548" modified="2019-05-08" version="1">MLEHRGFSVRLACEGQDLEEFSVNVDDERTISCYVPSEAGKTFSIVVKSNFDALVVFDCYADGEFARGSLLYPHTQGIVKGPYVDKTTVKPFQFIPLTVTDDEMVANPRDPALRNLGTIEVRFSRVKEGKYYRPSKGTKLSNLQPVHERCKKAGTHRVSYGDGVKSEKIRYNEPIWIDSRDQPYVTFRFRYRPRELLRAQGIITTEGVEANDEPSGSNTATATAETYESDSDIVVLDGPPLKKRRRNATPEVKPVIDVDTASLDMVGINEIGDDPNLAAMANQIRSLTKEFERKIRRKKRAIVDARVKKEKLEELDILPGEPNIIDLTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEI2</accession>
    <name>A0A401GEI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611493.1">
        <property type="nucleotide sequence ID" value="XM_027755692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEI2"/>
    <dbReference type="STRING" id="139825.A0A401GEI2"/>
    <dbReference type="GeneID" id="38777497"/>
    <dbReference type="InParanoid" id="A0A401GEI2"/>
    <dbReference type="OrthoDB" id="2803129at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8530" checksum="89A841FAC07AA6F6" modified="2019-05-08" version="1">MDTSSYLMKSTWDNITLSAEFKKANRDNDVDANVGGVSWSMRHVMRSDPCRRFAFGTMVEDTDTGASFCSRQLVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEI4</accession>
    <name>A0A401GEI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0303040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611502.1">
        <property type="nucleotide sequence ID" value="XM_027755701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEI4"/>
    <dbReference type="STRING" id="139825.A0A401GEI4"/>
    <dbReference type="GeneID" id="38777506"/>
    <dbReference type="InParanoid" id="A0A401GEI4"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="535" mass="58657" checksum="E5B2BEAC09E36C19" modified="2019-05-08" version="1">MTLGPPPSAAGSSHHAPDNHNSGSTVVSSSSEDQTYSGTPQDAPQQRALTVASSGNHGSHYQSYGQSSARFSTAQSTLPSQSYPSYPSTNNISQQLRTNQGPNQVTSYGYYNYSPTAWGNAWPAAAYPYGGTGTYQYSYPQTSPLIPSQTPSYPSAVPQTQSKPKTPSPSPSPPPPFHKQWDAVMKTFLSSVGLTQALRGFEADMVIMNTEWERKTVPTALGELMRELLRLGESKRAEEENAIAKQEQPEERSLEERKLDYVHFANGAVPRSQTSITKSISLFLAQNRARNDESNRTEFLQSLTEKRRRLSELGEESSGVISSCSRTDAKTQNRDVQMKYDIAKNEDGPLRKTLRVGSAPDASTAQGRSCRDATAPRGHAEQSFDDVGAELYPALDERLGNVETHLAVRYVPSPPRSLFDRLKFLEDHIIQLEKEYPPWAALHFNQPNRGWPPPPRPTPIIVPSHLTSTATNASQPHSPHSTEHDAGAVGSTTSDSNAPKGRGKQGRTNKSSLHRAVMEKLEVQKAMNDLAGQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEP5</accession>
    <name>A0A401GEP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0303260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611524.1">
        <property type="nucleotide sequence ID" value="XM_027755723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEP5"/>
    <dbReference type="STRING" id="139825.A0A401GEP5"/>
    <dbReference type="GeneID" id="38777528"/>
    <dbReference type="InParanoid" id="A0A401GEP5"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09245">
        <property type="entry name" value="BRO1_UmRIM23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="2"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="488" mass="53659" checksum="7252196E08456311" modified="2019-05-08" version="1">MSSYFYELPTTGAIYFASFFSDQTATYITEIAQATEARANLRAALKENKRADVDEKDYLKLVKVLDDYIPQLYGIFDCVKQGEFGLKAEPIFSWRTTLSSTLFHSSPRLTIPTLSTELVFTLLTYAFALSNLSRTVVHSLGAYEQDRAMSDTERKVKDERLGFAVTLLCKASGIFEYAGKECLGEWERERDRVLAAGLPCPHPPDLSREVVIGLSKMALADAQTLAIRKLLSKASFDSAFTPGPPLPKSHPSPVLIAKLHLECASLYSTARSLAKTPGDSRSASSKSKFKLQLGRDRGKAPDDAGEEVAPELRRYLSDEVAFHAALAHKWLGVDAGEHGGTSQCGHAVGFLVWAKKELEELKSGGGVMETEREKQMRERRREKVAEELERVTVFLKGYKTINDTVAFQPVPPQSDLQSSIPAGRLAVAVREYQRPSPAFGPGSVEYVQRQAEQLQLGANTENEGETVPPIDTSSPHSSSSYAGAGSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFJ7</accession>
    <name>A0A401GFJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0306810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611871.1">
        <property type="nucleotide sequence ID" value="XM_027756070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFJ7"/>
    <dbReference type="GeneID" id="38777875"/>
    <dbReference type="InParanoid" id="A0A401GFJ7"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592:SF27">
        <property type="entry name" value="OS08G0421700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47592">
        <property type="entry name" value="PBF68 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="317" mass="35126" checksum="1BCC8C03F25EA430" modified="2019-05-08" version="1">MVAKGKKRPFGEYKKCSICGKPGHLGNECRHRDKVKCMNCGKFGHKATDCWAKGGGKAGQGPPMKRQKTERAYEVREVESKEDEAKIAYDNDSDTVSLGSDGEIASFYEWFADSGTTSHITNHREVFATYQALEDHAITGIGPQPTQALGRGTVDVESEVGDRKVKFRLHGVLYALTAPNSLLSIMRLDDAGGRVLMGNSRAILIDKNKHTLAIGKKNGRLYSLKLRPIVPQPARTYTAKEYGPHTWEEWHKIYGHIGKPALTRLYREGLVDGLEISPSPDEINCEACIQAKAMRKPFPKETDECSKVPGELTHTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFW0</accession>
    <name>A0A401GFW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0308010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611989.1">
        <property type="nucleotide sequence ID" value="XM_027756188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFW0"/>
    <dbReference type="STRING" id="139825.A0A401GFW0"/>
    <dbReference type="GeneID" id="38777993"/>
    <dbReference type="InParanoid" id="A0A401GFW0"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="212"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="492"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="578" mass="65575" checksum="E70CE758B36C4DA7" modified="2019-05-08" version="1">MPEELHLEHDDQSAHTPTPLTAVAVAKEQSTSPLDSLLSPRKPDAHFSIRQSVAASDATDDEARFSTVELSSGRESASVSLTPSSSTLAQDDRRNTVGLPSPDAAAHNLNDFRQHKKTASTSTILSASNVPFMLSQREHDDNHTNSSRNSVDSQRMVQEEFSRRHSALQEQGAMADPEESAIDWDFWGDVVSDYQKFASEHPQELAKAIEKGIPKALRGMIWQLMTASKDPELESTYLRLLKDTSPHEKAITRDLGRTFPHHTFFIDRGLGQENLFNVLKAYSLYDTQVGYCQGLPFVAAILLLQMPDEEAFCLLVQLMQSYGLRGHFLPEMPKLQLRLFQFERLTEELAPVIHVHFLRQGIKSNMYCSQWFLTMFSYRFPLEIVLRIYDNCLANGIEALFAFSISLLLKNEATLLSLKFDQLLAFLNNRIYEVYLLDEPASEGEGESVAKYKVDEFVQDAMSLKITPFMLDSYTREYEETVRAREAHAVEMDALRNSNRSLSAQLKHLETSMSQLNTEHCELLNELVRARLKHEELESELVRYKLLYAEAMHQSEDAMSSHRLSTMSSPNRRGSNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG94</accession>
    <name>A0A401GG94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0308710</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612058.1">
        <property type="nucleotide sequence ID" value="XM_027756257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG94"/>
    <dbReference type="FunCoup" id="A0A401GG94">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GG94"/>
    <dbReference type="GeneID" id="38778062"/>
    <dbReference type="InParanoid" id="A0A401GG94"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE81145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="164" mass="17377" checksum="160888B993ACBBB7" modified="2019-05-08" version="1">MSALRLVSSAARRSTKTFATGRRGYAEAADKIKLSLVLPHESIFSSTDVVQVNISAATGDMGILANHVPSIEPLRPGVVEVIESSNASKKWFVSGGFATVHPNNKLTINAVEAASLDSFSAEAVRANLQEALKVAAGNGSEEDKMEARIEADVYEALQYALASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGL0</accession>
    <name>A0A401GGL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0310290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612215.1">
        <property type="nucleotide sequence ID" value="XM_027756414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGL0"/>
    <dbReference type="STRING" id="139825.A0A401GGL0"/>
    <dbReference type="GeneID" id="38778219"/>
    <dbReference type="InParanoid" id="A0A401GGL0"/>
    <dbReference type="OrthoDB" id="3219836at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="21864" checksum="6B8E1328A61BD519" modified="2019-05-08" version="1">MPAPETRHEARPILGHVNLMLDSFIANATADDLRAVVRTMLATSPPAVTSAFTTAARRHLEKVNARTPPTRVKLFVRLNDGTSRPSAELPHALRRARVLYGAGMGFTSLGVLTGFVRATIGLRWEEDSEIADVLAAIDADITQAIQSSKEEMAAGSVTDIAAARTAVGELHAALIDSSRDVESWNGEFPFERAVASIQYWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGY3</accession>
    <name>A0A401GGY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0311850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612369.1">
        <property type="nucleotide sequence ID" value="XM_027756568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGY3"/>
    <dbReference type="STRING" id="139825.A0A401GGY3"/>
    <dbReference type="GeneID" id="38778373"/>
    <dbReference type="InParanoid" id="A0A401GGY3"/>
    <dbReference type="OrthoDB" id="2802152at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019127296" evidence="1">
        <location>
            <begin position="22"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="427" mass="45265" checksum="ADA5E1601F0EC5F2" modified="2019-05-08" version="1">MRSTIAITAALVAASAAPSLALPIAPASGSEAVNWKKVGSVAGDVGKVALHFLREEDPIVARAFEDELLARAAPAGSEAVNWKKVGSVAGDVGKTLLHFLREADPVVTRADGSEAINWHNIGNDFKQFGEGVISRAEPAGSEAVNWKKVGGIAGDVGKVALHFLRDDGSQAINWHNIGHDVEQFGEGVVGRADAGSEAVNWKKVGGVAGDIGKVALHFLREEDPIVARAFEDELLARAAPAGSEAVNWKKVGSVAGDVGKTLLHFLREEDPIVARAFEEELMARVDGSEAINWHNIGNDFKQFGEGVISRAEPAGSEAVNWKKVGSVAGDVGKTLLHFLREEDPIVARAFENELMARADGSEAINWHTVGHDAEQFGEGVFGRADAGSEAINWKKIGGIAGDVGKVALHFLREDELLARGLALNELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHK4</accession>
    <name>A0A401GHK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0400550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612597.1">
        <property type="nucleotide sequence ID" value="XM_027756796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHK4"/>
    <dbReference type="GeneID" id="38778601"/>
    <dbReference type="InParanoid" id="A0A401GHK4"/>
    <dbReference type="OrthoDB" id="2637024at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23648" checksum="63E9CE6BACBA1BCC" modified="2019-05-08" version="1">MAAVASFELAGSLAKSSGPVRRFTTCLLQSLIRPYNEQAVGVNAEFVFPSFHSTSSLSLFPQLPCASFFVCPFMRRLEPPYPSFTLVMSLLEGDVLRAPTYHDWYHANTTSPSCRECQDRLMKTVDYRYTEEPVFEEPPSMTLHPQRVGDDILDCDVSMLDLNSSVRREVAVNVRRGDSAKVPVIIQTVVLAFKRSYRALRSRNPAHGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIC6</accession>
    <name>A0A401GIC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable diacylglycerol pyrophosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0403010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612840.1">
        <property type="nucleotide sequence ID" value="XM_027757039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIC6"/>
    <dbReference type="FunCoup" id="A0A401GIC6">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIC6"/>
    <dbReference type="GeneID" id="38778844"/>
    <dbReference type="InParanoid" id="A0A401GIC6"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000017">
        <property type="entry name" value="Diacylglycerol pyrophosphate phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF35">
        <property type="entry name" value="RE23632P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="135"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="371" mass="41508" checksum="114A570D2D7B57B2" modified="2019-05-08" version="1">MHSHPQVQKSPETYPLHFLPSPLPQPNSNPSFMTGTRRPGPMMDSRRRRQLFWSYAPDWIVTIGLAAIFIGLSNVPGFKRDFSLQDQTLYHPFAVHERVPDWALYIICGVAPLTLQPIINLLSVRSWWDLHNSVLGLALSLSMTGVITQFVKMTVGRPRPDLIARCIPAAGAVDPPYGLATVTICTQTNKAMLKDGWMSFPSGHSSLSFAGLGFLAFYLSGKLHLFDHRGCAPKAWLALTPLSGAALVAISRTMDYRHHATDVLAGSLLGIIVAYFSYRQYYPSLASEHCQKPYSPRIKNRGEILPMHRRSQSNLPTDPLTADGDRYTDERLSEEFQELANETVPRDEDGHEIEMPKNDRVPSPTSRDLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIE9</accession>
    <name>A0A401GIE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0402650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612804.1">
        <property type="nucleotide sequence ID" value="XM_027757003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIE9"/>
    <dbReference type="FunCoup" id="A0A401GIE9">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIE9"/>
    <dbReference type="GeneID" id="38778808"/>
    <dbReference type="InParanoid" id="A0A401GIE9"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="11">
        <location>
            <begin position="99"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="12">
        <location>
            <begin position="237"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE81891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="737" mass="82804" checksum="80B72A4191B8B1AE" modified="2019-05-08" version="1">MTAVSSSSRLNVNSPQPQNIISLRLYKVLGASFDDDATKEALRTVAELYAPPVPTVSVKGKEVQRELDDADEGEGVKVQARSQLDGTPLVEVVPGEIAARARKNLRRDVESKLAESSRKFLDAFGEVDKQLDTLQEHIAAMRMRCDEGQAQLRLTSEACGSLLDRAGSLREERQAVATRQSIVSLFLSRFTLNDEEKEAISSRDVPVGMRFFDAMDKADRIRDDCRVLMAGEEGPTKAGLDIMAATATYLEQAHEKVFRWCCSEFRHMGRDAQLEVSPVMREAVRRLRQRPELLTEALGYLSQTRQATVLAAFTGALTRGGPGGLPRPIELHAHDPLRYVGDMLAWVHQAIAAEHEFLESLFGVRADGRMVGSVRQFGDSVEEELISELMNAAVGKLCTPLKVRVQQTVRSQESSITLYKIANLLKFYTLTMERTIGEHALLSEALKQMTDMSFDAFLDNIEAQSRALIHIPLGPDDKELTPPLVILDHAQVLREIMIVYASSLQSDEPKDTLHPGFRQILDKMVDPAVEMCISAAEVKKKAMPWWDRSVFVLNCLAYMQSLLEPFPFTKEKQAVIHELMDHKILQLTEEHYKNILWEAGFNEVVEAFTQQKPGEPLSYIYGTTIYRLQSALRKFSTWLSGITVVHSNRLSHLTVQSHATRVHQAVLVRIARIYERLIGEMRKPENKYEAAATLLAGERPFGQMHLLWQIFGMQDQAFALEGQTEPGDHVGLEKQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIH0</accession>
    <name>A0A401GIH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0402850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612824.1">
        <property type="nucleotide sequence ID" value="XM_027757023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIH0"/>
    <dbReference type="STRING" id="139825.A0A401GIH0"/>
    <dbReference type="GeneID" id="38778828"/>
    <dbReference type="InParanoid" id="A0A401GIH0"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="10325" checksum="3C523B0B0C2018A2" modified="2019-05-08" version="1">MRCTLVELQELSYVLCHVYASATRSVSIPAPVYYADRVCARAAYHFDPATDLHLDDETLTSSSDAHREFDMTRWQAAFRQSAMNGRLYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIV8</accession>
    <name>A0A401GIV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable RNA 3'-terminal phosphate cyclase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0404670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613001.1">
        <property type="nucleotide sequence ID" value="XM_027757200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIV8"/>
    <dbReference type="FunCoup" id="A0A401GIV8">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIV8"/>
    <dbReference type="GeneID" id="38779005"/>
    <dbReference type="InParanoid" id="A0A401GIV8"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="167"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="38326" checksum="5C343ED7FE0D8FA4" modified="2019-05-08" version="1">MRHRLVLSVLSGKPVRIDKIRSSDKNPGLRDYEVSLLRLLERITNGTVIEISVTGTAILLKPGVIAGGQATHDCPLSRSIGYFLEPVVMLAPFAKKPLQLTLRGITSDDHDLSVDLIRTVTLPHLQLFGVSEGLELRIKKRGSPPLGGGEIQFLCPIVRQVKTLNFVDPGKIRRIRGISHAVRVSPQFSNRMIEASRSVLNRYIPDIYLYSDVYKGEDSGKSPGYGLSLLAESTTGAMHCSEATSQPGVAPEDIALLASRALLSEIRRGGCVDRRHQTLVLLMMVLGSEDVGRCVMGEPTPRTTQFLRDLRDCFGTSFMIAPADPKDESSSQLLFSCYGVGFVNVNRTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJQ8</accession>
    <name>A0A401GJQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0407850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613314.1">
        <property type="nucleotide sequence ID" value="XM_027757513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJQ8"/>
    <dbReference type="FunCoup" id="A0A401GJQ8">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJQ8"/>
    <dbReference type="GeneID" id="38779318"/>
    <dbReference type="InParanoid" id="A0A401GJQ8"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="248"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE82401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="454" mass="50908" checksum="F80B4CA1E844E94B" modified="2019-05-08" version="1">MPREIVTVQLGQCGNQVGSVYWQRLCAEHGINKEGILEEWATEGGDRKDVFFYQADDEHYIPRAILVDLEPRVIHSILTSPYANLYNPENIFVSQDGGGAGNNWAQGYASGERIYEEVMEMIDREAEGSDSLEGFMLMHSIAGGTGSGLGSFLLERLNDKFPKKLIQTYSVFPNAQEGDVVVQPYNALLTLKRLTNHADSVVVLDNGALSRISADRLHVQTPSFDQTNQLVATVMAASTQTLRYPGYMNNDLVGIIASLIPTPRCHFLMTSYTPFTSDQIDKAKPIRRTTVLDVMRRLLQPKNRMVSTTPSKTACYISILNIIQGDVDPTDVHQSLLRIRERQLANFIPWGPASIQVALTRRSPYIATNHRVSGLMLANHTSIASLVKRMIDQFDRLRKRNAFVEQYKKEKMFENGLEEFDDARATAEELLKEYKACESPDYITYGSADAEPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKB9</accession>
    <name>A0A401GKB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 24 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0409870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613515.1">
        <property type="nucleotide sequence ID" value="XM_027757714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKB9"/>
    <dbReference type="FunCoup" id="A0A401GKB9">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKB9"/>
    <dbReference type="GeneID" id="38779519"/>
    <dbReference type="InParanoid" id="A0A401GKB9"/>
    <dbReference type="OrthoDB" id="10254187at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="264" mass="29181" checksum="A52FA1303F755094" modified="2019-05-08" version="1">MSWSAAAAPSILTGGRVEMFAARLSKRIRFRPAVSARNVSSTACRKSDALFVHRDTTYNNPKIPFEFNAANTKRAQEIISHYPPQYKKAAVIPLLDLGQRQNKGWTSISVMNYVAKLLEMPPMRVYEVATFYTMFNREPIGEHFVQVCTTTPCMLRGGYDILNTVCDHLGGVKPGETTKDGKFTVIEVECQGACSNAPMMVVGDDYYEDLTTETTKKILDAFKKGEKPKLGPQSGRHTSENSAGLTALTSKPYGPGEFCTPEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKM0</accession>
    <name>A0A401GKM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0411020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613630.1">
        <property type="nucleotide sequence ID" value="XM_027757829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKM0"/>
    <dbReference type="STRING" id="139825.A0A401GKM0"/>
    <dbReference type="GeneID" id="38779634"/>
    <dbReference type="InParanoid" id="A0A401GKM0"/>
    <dbReference type="OrthoDB" id="3363386at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="666" mass="70308" checksum="73366CC4F128BD36" modified="2019-05-08" version="1">MTTIIHLAYTPRQGILLNPSPSVSPYQHSSPLPLFVPSNTSLSSSSSSALNTDSEYCLGSSSSTSNSKEPSPALAVPRPLPTHSTTPHCSNTRSDSPAATSRRIRFAPLPDPRRDEEPFALPPAILDDSGSSSITESTVLNALGLGLRSPADDHKARSPRGDRSPRFSPSFFYDAKAPPASESTPTLASTATAASSCTLTTPHIPRPAHSPPASTDSSPAAPTVCPSGSASLPSSTPPSDTDGEWDVLTPSRDAAAAAPRKAAHKWSKKLFKPLLGPLAKGAPCSGAGAGDEADAKAKAPSKRQRDRSGSRGRDTTPDWVKEFGMPLGRWQSDDVPRGPAPKKGHRGVEFGRTQSLDREEEELLEASLGRISSNHGGRRQQRMLNGRVYGAKRNPFANARPDPQFVEWGYGGMGSVQASNGHASIWSKVQSSGAINVGAHDSSQSWGSRPSTANGRLTGNGALGNSTNTSGAAKASASDDDGTGMAWVRKRREQRERERKEREERERKEKEAGAGAVAVPPGVGDVHMRGSESGPPSASEREGKEKEKVEQKEGHVYTAVTVPARAAHPRKDGRVVLDPPHGVQIIVTGESEELVRTASKESVGGAGAEGSAEDGSGEDEEESPRGEGEEEDEEEDEMEERSRLTALGAGVEKISRHKESASVASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKN1</accession>
    <name>A0A401GKN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0411130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613641.1">
        <property type="nucleotide sequence ID" value="XM_027757840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKN1"/>
    <dbReference type="GeneID" id="38779645"/>
    <dbReference type="InParanoid" id="A0A401GKN1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="424" mass="45639" checksum="765A189498E397C4" modified="2019-05-08" version="1">MGKAKKKGKPVRKVMGKAASKATKGKAAPGGAKGGGRKCKMKDAYDLEDDARSSQDSDRSSPDIPSIASEEDTASDEDLGDGESVIANKAKGKAVTTTNGRKANNGGAPQASGSSGAKTKAKRGLQDLLLGELHRFDTEETDEAWSELEPSTKELRLELQGRAPRLTGGSTVGSTVPHLVKRRDMFLATLSVEPRYQDMLKEVKIATVPQVYRFTRYDPIPWSEWSYGQRYLPPSFHAVDNFDIVENWLGDKPWLTKYRFLHPQGVQQSALMIGMVLRDLTRSQFIEKGELTNLPDYVVNSAISFDAVEQLLRCCEIITLDMVEGNITHAMVKPVSKPAIRGAPQGGDGLGGQEEQEGDASARTHDGAATAAKVHKAHQPAPMADKPIIPSGGDEGPSQETSGEASDDGEEDDAHLSVPSSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKS7</accession>
    <name>A0A401GKS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0411370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613665.1">
        <property type="nucleotide sequence ID" value="XM_027757864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKS7"/>
    <dbReference type="GeneID" id="38779669"/>
    <dbReference type="InParanoid" id="A0A401GKS7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="214" mass="25014" checksum="6479B4E33565EACE" modified="2019-05-08" version="1">MSTFKFPSSEEIIDEDWCIRDRLPRHCGGWERPYSAPFGKLLEHWQARDKGYIGKKETYPRAQDVRFFEPTDPSFWPIVIVSSENVLPESIDDTLKKFSLFVVEEIETPLPDQNITCMGVYVMKDMEKNLTVKGWNKLPEKTKNACIELELQLSWLREHSSSEDVAPMIFSKDTIRKNYDGGVSQLSLLVLERKDFRVKPWESWTVLQKSQNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLF0</accession>
    <name>A0A401GLF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">SCP_0500410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLF0"/>
    <dbReference type="FunCoup" id="A0A401GLF0">
        <property type="interactions" value="916"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLF0"/>
    <dbReference type="InParanoid" id="A0A401GLF0"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="233"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="465" mass="53261" checksum="9112494516EE4975" modified="2019-05-08" version="1">MAEYDLTKTIIPYCDRHLVFPLLAHLVENELFPVEQVQAAQYMLAKETNMVDYAVSLFQQLHPDEEIPEEFSGKREKAVSTNERLQQEAQAVLNVIENPEVAQSLRQDKNQNLQYLKEHYNVTLEQITALYNFGQFQYTYGNYSGAADYLYHFRVLSTDPDLTISAHWGKLASDILTGKWDVALEELNTLREAIDSRAPSVPAFATAPSTSTTDPALAQLHSRTWLLHWSLFVYFNHPQGRTLLLETFLSPTYLNTIQTSCPWILRYLTTAAVLSRKSASGALSSRVRHSIREIVKVIHMEEYQYQDPVTAFLKELYVEFDFEAAQRELSKAERVVANDFFLSEFRDDFMDNARYLISEAYCRIHQRIDIGDLSERLNLSRDEGEKWIVNLIRETRMGADAKIDLEKNVIEINRPPLPIYQSVIEKTRGLAFRTQALGAAMSRTQLPQPLGVQEEGQPAVVEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLX9</accession>
    <name>A0A401GLX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0390 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0502420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0390 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614108.1">
        <property type="nucleotide sequence ID" value="XM_027758307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLX9"/>
    <dbReference type="STRING" id="139825.A0A401GLX9"/>
    <dbReference type="GeneID" id="38780112"/>
    <dbReference type="InParanoid" id="A0A401GLX9"/>
    <dbReference type="OrthoDB" id="5239630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967:SF1">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="93" mass="9765" checksum="88476D4D69D8257E" modified="2019-05-08" version="1">MVQGQTKGLKKHKSSTSRHAAKAAAAPKKGKRYIAPKKAAAVKHAAIHRELSAKINKSIEHQVATAASSGKLTIMKNVALEGVAKAAKSKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM14</accession>
    <name>A0A401GM14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">rRNA-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0502570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614123.1">
        <property type="nucleotide sequence ID" value="XM_027758322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM14"/>
    <dbReference type="FunCoup" id="A0A401GM14">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GM14"/>
    <dbReference type="GeneID" id="38780127"/>
    <dbReference type="InParanoid" id="A0A401GM14"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="177"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33718" checksum="4468612361EA05DE" modified="2019-05-08" version="1">MALTALQKGKSKAALEDSAEHLISDGTSSSASRSADSDSDSDSESESDTDSDTGDEEVTQEFLNALLVRARHNVTAKTLPEGDRSGENLHEEEEIRLDDLKDPEEQPLPPLDPGVLPAPYITLGDARKAAPSAIRHPDIEQVEQASSSNAPARPLPPPELSKSGKPLTKKEKKALKDRTAGRSWYDLPAPAEADLPRLYREVEALRLRNQLDPKRFYRKDEGEGRGIKGLPKYFAIGTIIPSSTPFGTASADNLNRASRKRTLVDELVDDAEAKSYAKKKFKELQTVRGARGRGTLAQKKALRRQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMG6</accession>
    <name>A0A401GMG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">threonine synthase</fullName>
            <ecNumber evidence="4">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0504900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614354.1">
        <property type="nucleotide sequence ID" value="XM_027758553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMG6"/>
    <dbReference type="FunCoup" id="A0A401GMG6">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMG6"/>
    <dbReference type="GeneID" id="38780358"/>
    <dbReference type="InParanoid" id="A0A401GMG6"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000024">
        <property type="entry name" value="Probable threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="93"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE83441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="537" mass="58982" checksum="FAF950DA27302203" modified="2019-05-08" version="1">MRYLSTRGGDELLSFEETVLTGLAPNGGLYIPERIPSLPENWQTRWQNHSFVDLSVEVLSLYISPAEISRAELRALVEKSYRTFRHPQVTPVKKLGARMYVLELFHGPTFAFKDVALQLLGNLFEFFLVRKNARKDAAEKLDKLTVVGATSGDTGSAAIYGLRNKANISIFILHPKGRVSPIQEAQMTTITDANVHNIAVNGTFDDCQDIVKALFADHVFNKKHRLGAVNSINWARILAQTVYYFLSYFRLRALLGGSSDFELQYVVPTGNFGDILAGYYAKRMGLPMGRLVVATNANDILTRFWQSGAYEKVDSSVASGGASDGKQATAAYGVKETLSPAMDILVSSNFERLLWYLAYEDPALAQENLSAKEHVRAAGATVDGWMKKVKSDGRVKVPTAVLELAQKDFLAEKISDAQTLETIRFYYGSKPSYVADPHTAVGLSAARIIAPQNPPSTVQVVLSTAHPAKFSEAVTRALDGSAGFDFARDVLPDEFKGLLERERRVIDVQSPDVALVKKVIEKFAGDESPAEAFGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMS0</accession>
    <name>A0A401GMS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase family 90 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0505290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614393.1">
        <property type="nucleotide sequence ID" value="XM_027758592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMS0"/>
    <dbReference type="STRING" id="139825.A0A401GMS0"/>
    <dbReference type="GeneID" id="38780397"/>
    <dbReference type="InParanoid" id="A0A401GMS0"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="4">
        <location>
            <begin position="282"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="622" mass="71838" checksum="12A0D4DE13830788" modified="2019-05-08" version="1">MIDVLSGQRKGWLFFVVLIVAFMQGGLWAGRRRGPDNFPDNSLVRSTSSYIPFHRRNARPVVKEHPIPKLMAEAEDKFRKLLARQSRTLAQAVVEYERRYGRKPPRGFDEWWRFAQDNDVLMIDEYDGIVEDLSPFWELPADELRTRAVLAGHLPSVDMVRIRDGKSMAENIKDVHTDISARAKGFRKMIEKFQDKLPDLDFPINAMAEGRILVPWEQRAFPNETSDSILAELSGMYSPDWRGEGNVWEAYRRTCLPGAPARRLFSSFRASSSERTSQLLARNEEFVFSTDVSGNYSFCLSPWAHYNQGHFFSDWRTIPALFPMFSPAQAPGYSDIRIPSHYYYGQTRRYTYGYDSVNLQLKEVDHMETPWEYKNDKIFWRGASTGGGSSPPGFAAQYQRHRFVRMASDRSGTNRTMVFADPPGSSNYIYAEVPVGMLNDEIMDVAFVNLVDWYNFPGGLLALVRAHRFDDGGVSLGDHWKHKYLVDIDGMGYSGRFFSFMESDSAVMKSTVYREFFSDWIQPWLHYIPVSQSYQEIYNIHAFFSGATPSTLKIANSTALDLLPDQRRTIDGDRRLRRIARAGKQWKRTIGRRVDMEAYVYRLCLEYARLMSDDRDSMNFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMX9</accession>
    <name>A0A401GMX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614476.1">
        <property type="nucleotide sequence ID" value="XM_027758675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMX9"/>
    <dbReference type="STRING" id="139825.A0A401GMX9"/>
    <dbReference type="GeneID" id="38780480"/>
    <dbReference type="InParanoid" id="A0A401GMX9"/>
    <dbReference type="OrthoDB" id="3143319at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="442" mass="49289" checksum="E66B4FC4660CD775" modified="2019-05-08" version="1">MSTQQNEDQVTVHSWACHDFQPISSQELLDKGRFLVRAASRVDRWFQPVIKASANIRSCGAAFEYSQHAPRCDSLDVRNQVAMTDLLQEWSSDVTVDENEAFRLEDLEEFQNSDLTCVFHKPSITALIPAMPPANQLAPGLEPKRSRKGIIGESCSDEPPRKRPRLDHSSLSKLLPQPHFHPSVFSAGDFSPSDIGRNAFYPKLTSRPVPPHTEEAMQEYLADPYARGAWIIPVRGTLPWDDCTSASILAAPSTLSQEVRILLPSGPSSRPGQFPADLLSDEITWTHHALSTFWEFLLAIRDAGTLGPLSLSFHAAPVTDPAESSWSNALLPGNHEHYGIHRSATDNSFPPLRSPLFSVDHIKVYHDTQYTKHVRNVLYAWSYSCVLAEDGSVHDAPQVRQRGKREASTSRMGKDLNLQKIRMLKGARLVLVDEKSKAVLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNA3</accession>
    <name>A0A401GNA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0507770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614634.1">
        <property type="nucleotide sequence ID" value="XM_027758833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNA3"/>
    <dbReference type="GeneID" id="38780638"/>
    <dbReference type="InParanoid" id="A0A401GNA3"/>
    <dbReference type="OrthoDB" id="3236701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="100" mass="11008" checksum="B762E1C35BFD5C74" modified="2019-05-08" version="1">MFRSSLRHNSSSCDLSTIPPKEFKVLLDNQTLYVDQELAEALGWKANGGPEGLSLTLNGWAPHYFTIAPTGTDSDLLSRATVESSRNPNVQAVLAYLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNN3</accession>
    <name>A0A401GNN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">(R,R)-butanediol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0504020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614267.1">
        <property type="nucleotide sequence ID" value="XM_027758466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNN3"/>
    <dbReference type="STRING" id="139825.A0A401GNN3"/>
    <dbReference type="GeneID" id="38780271"/>
    <dbReference type="InParanoid" id="A0A401GNN3"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="9"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="359" mass="38030" checksum="98F9FE5182A5B4CE" modified="2019-05-08" version="1">MMRAVRYHGPGDVRVEEIPEPVAGDGQIKIKVAWNGICGSDLHLYHALLPPITPTLITPNYVTGETLPVVMGHELSGTIVELGAGVDSDKYAVGQNVVVEPVLSCMEPSCGPCTAGTRNVCPHLTFIGIGGGGGGMAEYISVKQNLVYVLPAGIPLEVGALMEPLSIVWHAINRSNFKPGDNVLILGAGPIGLLLLKVLRARGAQWIGVSEPAARRRETAVEFSASIAFDPSSTDVVAETRRATQGQGADVVFDCAGIQASIDTAIVAARPRGNVTNVAIWEKSPVIDLTTMTHKEVTISSAVGCDRVHNDLIRAVADGKLTGLEALITRKIAFEDVVEKGILALIHEKDTQIKILVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNP0</accession>
    <name>A0A401GNP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0508830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614739.1">
        <property type="nucleotide sequence ID" value="XM_027758938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNP0"/>
    <dbReference type="STRING" id="139825.A0A401GNP0"/>
    <dbReference type="GeneID" id="38780743"/>
    <dbReference type="InParanoid" id="A0A401GNP0"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="745" mass="83103" checksum="F2E973B6C1539B75" modified="2019-05-08" version="1">MVAVTEPAAPAPSPPAVGTCIDNGTLELVEILGYGGYGVVYRAVDIFSPDISYAVKCLPHSRKRNAERQRQLHLREIMLHQLSSAHPNVVTLHRVIEDFNYTYLVMDYCPDGDLFTQILHNRRYLGSNKLIKEVFLQLLDAVEYCHSLNIYHRDLKPENVLCFDGGKRLAITDFGLATTEKMSTEFRTGSVYHMSPECQGGYFAPTKSYSPLFNDIWSLGIILLNLITGRNPWKSASVEDCTFQAYLQDPMHFLPTVLPISEEVNLLLSRTLEVDWRRRITLREMRLSIMVIDNFYSPDVLFEDSMARCPWEAGIQVDTDSESSEEEEEPEPEPEPKELPEAQDEGIASTWSNDSESDMVFATQSVTDKSSWAYSESYAKRDSYARSMSPSPDSPLFTTTKLFEMMNTPSAVSAYSILSSSPSIPSLPVTPEGGESLQPADSRRPKALTLNTADCHPSYYDSSAMMLSARSSTMHTALDSASQFDSYGYCSIFAETMPTKASLLLDSTQDIGMITTPITAEEHMDTKSMCSYPTIDADQSMDSARPESPILGLSTGVNTAVKPEADWEQAPLSAYSFLTFSSTPATSPRTEQPWPAFSFLSSLVPHSEHTPKGSFRTDTPPLPSRPPLSPHAHDRKSRASTFMRPIKLAFTRRASSHDTHSTKGRLSRTMQTESVPTLVGPNWVFTASTSRSPSPQPHRCLPSSEKDAPRKKFADSEGLRRRRRRLRSPRAWFSSGKLFASVLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNR9</accession>
    <name>A0A401GNR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0509200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614776.1">
        <property type="nucleotide sequence ID" value="XM_027758975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNR9"/>
    <dbReference type="STRING" id="139825.A0A401GNR9"/>
    <dbReference type="GeneID" id="38780780"/>
    <dbReference type="InParanoid" id="A0A401GNR9"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="387" mass="43894" checksum="5371EA6F2596CC7A" modified="2019-05-08" version="1">MMNDVLREHLDKFVMVYLDDIIIYSRTAEQHTKHINTVLQTLNSHELVLNQDKCIWGATELLYLGHIISHKGIRPNPEKIKAILTWPRPQTITQLRGFLNISGYYRKFIRGFAKIASGLYTLLHGHPQKGAAIEWSEACERAFDTLKTQLTTPPLLVYPVPWRVFVIDSDASGECIGGISQQPISLLETSNEGGEVEEHDDTASDTRFEFRDCDLRPITYESRRLTPTEQRYSVQEREMLAIDYLLQKWHAYIEGSPIIIRTDHESLKYSLTQKNLGRHLQRFADNIAHFNVKIVYRPGKFQLAADALSRREGEAVPDSEMLGPLYGYPMIDAGLRSCNSSEESIFRDSDEASDDEGPVAPPATPAPPEPADRPAVDSDEESVEEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP42</accession>
    <name>A0A401GP42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0510470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614901.1">
        <property type="nucleotide sequence ID" value="XM_027759100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP42"/>
    <dbReference type="STRING" id="139825.A0A401GP42"/>
    <dbReference type="GeneID" id="38780905"/>
    <dbReference type="InParanoid" id="A0A401GP42"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="743"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="427"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="602"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="826" mass="88490" checksum="9946DB0F28B09C35" modified="2019-05-08" version="1">MQPSQEHTGHAPSRLSGVPMYHVQDHRVGSPTAHVVQQAQPSYTSYAIPHSNTAALPAMQHQHQHQSQPSSAYVLPALTQALAKLHDHTYERFEHVEGSIKTVLDNIAAAEERARSETSQLAQWIERSHILQIKAVQSVLGRVQKLDGLIGGVSEPQPDVSVKDRLQRLEYALQELLEKTVDPQAPPAVSDRIDKAVNTSPHLVARDLVDKGIDPHLPNAEKTYIDTGVDAPVVRFMHASIDACAAMIDASTDALTPGKANAEVDALRPLYSDTAVHAHSAVHVDTDVGFPQRDSRSRSLSYVHMDLAAFGKAVPVQTRFPSSPFASEPMAPAAWTESSDTASPSADSNNTPRLKAENLPVSSGALPEHRAIEDDDRKEEGTSAAQREADSSDPDPDELGLFNPIDGSPQSEGVATPIALPVITHAPSSASSKSVLSSASPSASALTSPAPVSTLDAPSRSSTVSAVSSSTVAAGSTAARGTPSSLSKTLAPSSSPRLRLPLPRNLKSMPPSPALSTLSSLSSLSSLAGSQPSSSAPASVSSPSIQLASIPPPESQPPERDDSPEIQIIEPPPTHGRAKRRGKSGSTLKKPPAERPRKRRKTDGDALESVKVEQTKRRGRPPRHSTGAPRAGGRAVPSAAMADGRALEPEGETPPCRWPEKARNGEMQREFVQCDNCDAWYHFGCVGLAAGDPRLDPDASFHCPPCESSRQQRVRRHGMDIRNPGCGRPDCDHKGQAEETHEYFVERIIGRKPHGVTNDEPPAEFLWLVKWDGYKAVAATWTLPIHLGDCAGFIDDFENAALIEGHDLEDSYATVLLNEAAAVGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPF9</accession>
    <name>A0A401GPF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615028.1">
        <property type="nucleotide sequence ID" value="XM_027759227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPF9"/>
    <dbReference type="GeneID" id="38781032"/>
    <dbReference type="InParanoid" id="A0A401GPF9"/>
    <dbReference type="OrthoDB" id="2803071at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="368" mass="41848" checksum="1006FDD996C88D48" modified="2019-05-08" version="1">MNSTHLTLHDRFLTSTIFLNEDFFLSPYPETRQEYLGFCERREKDARAWRPYMGTPFSAGVVKQWRSFDLPCLTADPLSDNYRPIPALVQHEAFLREGKISLAMVHPLQIGTRKWSQVWRGSMKMSSADDVLQAAPVVIKIFQQSLFPDPFEYHSEAGGIDCGGWLTGAQQARWEAWAFSRMKLLQGRRIPWSYGIFQIILPHGELAFVHVIEFVEGSSGKELRFGDATATDFWALAEVLASDFYNMTQCGVLHDDIMLSNLIVSPGDPHPVVSIDFAFAQPFTEADLDCGVFPIVYALRDMGMELDTIEAWFKDGITRGVPWSRMFVYQSEKSPRWFKALTGMITPDHAAEEVLKIFNRCLLPAVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPR6</accession>
    <name>A0A401GPR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0602030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615138.1">
        <property type="nucleotide sequence ID" value="XM_027759337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPR6"/>
    <dbReference type="GeneID" id="38781142"/>
    <dbReference type="InParanoid" id="A0A401GPR6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019497050" evidence="1">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="82" mass="8653" checksum="3BD8B495AFF77DC2" modified="2019-05-08" version="1">MLVVKAFPFTVLLLAWSAATIPSPGTTTITRTRAMQDVTTSTVIAMRTSEVFVIVPKTVDSVVTTTSVDAVFSTTTTTVPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR37</accession>
    <name>A0A401GR37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0606780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615611.1">
        <property type="nucleotide sequence ID" value="XM_027759810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR37"/>
    <dbReference type="STRING" id="139825.A0A401GR37"/>
    <dbReference type="GeneID" id="38781615"/>
    <dbReference type="InParanoid" id="A0A401GR37"/>
    <dbReference type="OrthoDB" id="5367135at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44190" checksum="AB144F5C8A66BEFA" modified="2019-05-08" version="1">MSIPDEMKHPERRGLVIEVDHRGGLKHADINNAQNWAVVLQFLSDGKLSYGSGFFLNFPEVSDLLILTAAHNLISPTNQDSEQLRVYLADGTSLDILGSWVCPRYRGPREDVDDYGAILVQRDPKVPAKSGFGFNMKLGQLERLPGNIFVTGYRAQGQTQRTPTTSTGPFVACHDGLQIEYRVKTEQGISGSAVWLDYDGFPTVVAIHNHGPAYVGGGSRGSLLSPTLFREIFRWLDVGQYGKKLCVQDSRSNPQPGTEPPKAGLYLYFPDDWPFARVRLGFGTAFDVLPVQVAAGSDKVRYALAVGEKWVLFNLTTKLAVLSDKLMDPCLFTKDEKKKKKEMRIVLEHPTTKKAFQLRLEGDMISEFDGDDAESSEVSMVPHPQDNLDRFTTFAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRD2</accession>
    <name>A0A401GRD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0606900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615623.1">
        <property type="nucleotide sequence ID" value="XM_027759822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRD2"/>
    <dbReference type="STRING" id="139825.A0A401GRD2"/>
    <dbReference type="GeneID" id="38781627"/>
    <dbReference type="InParanoid" id="A0A401GRD2"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1170" mass="130986" checksum="D2CC025D0E2BBEAE" modified="2019-05-08" version="1">MAHLLVWPGKYYLYAIGNTPAVCLTRDLASEEDADILLLGCGDPRNVLYTIFCEPQNSERKLDFTCCDFEPAILARNVILLTMLVDKLPVTTVVWNIFYHMYLDKQSMTVLTEHCKKLISISDTLQHWNDSRYGTFIKMCTEYTLAEIRRHWSLFADMQNLPGARLQAIRDAFSELSKSVSQKKGTTLTSARSAGPLLVQAIRTTAEQFRLYWRNGVTFSDSKQITAAKLVNPTFVYSLAGEGCPIHYATDPLVPFHIGSVFGNAKGSVTVSDVVKAARFEFNDWCLAFLSAISTIGTHTAIIRFFVGEATAVCRVLRGFSTTGILNSTVPVAQWKTQLIQLNREDYMTGGAPASFNVIETSNLDDHIGLLNVLIAAVPLLSTSTYSNVIYTESLLSHEQDSTKEFSERLYADIGTMGFLLGLCPVDYLAGYTTRSNTHELMMYQFLGKKDVTQFHQVTTWKSPYSGDSLALQNGVASRPPDFDSRQLGTLFYDIYFQLFQLEDASRHFNRHNGPNMMKAFRSSNILHYMRESFVLLLKLVRDRLRISHEQWLEVMDRFIEVREADTSLSMDSVNFQDLCAHLYRHGVYTIFFIPVMPPGPRIGIFSEWDTVPTLVRIILIVPREKLDVLDESNEQVGTPILQCDLRGTWSHNVYSAVHVAFGRATKMGTKARPWVSFEEDPDGKRGTSPLVASFTVAVRALTEIEPMQQLSIGLSVRSTLGTVMLTKKLGLTLSLFSAPLMDESHVLVLPEPSLPSRAVQAPLPSPSQSTGPLIGGVGDVSVELDEQCELVSSMTCKVSVEDEEVKTLFGSQGATPEISQVSPCVMRLTVGRHVQNVVYPFPVIGSQNRLRLARKSLYIEVIVSPFGPFKSDGMKLNPFPVVRSEKTLALWSIHHVNLSRMPVLDIKASQVAEWLNPHIGSMMSKRERSLRRKHKDDDVLTLVKDTVHTIFVHSTGLQAGPARRLFALQDDATRNCDTIFFISDIRFDLHSHTVVCDGYVLPLTKELIMRTERSFTKLIAEGNLVNVAAFKGEMQAWKQLLPALVERCRSSWQHGDNCEYKSQGRIPLTTEMEADPLCSCGRGKDTDGMSKVALWKNFAPYVTRIALSPLFAVSYLETVGRDPAAHKCSVCRGRGKPKLRACGGCKKVRYCSEACQKKDWKAHKLRCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRF1</accession>
    <name>A0A401GRF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615708.1">
        <property type="nucleotide sequence ID" value="XM_027759907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRF1"/>
    <dbReference type="STRING" id="139825.A0A401GRF1"/>
    <dbReference type="GeneID" id="38781712"/>
    <dbReference type="InParanoid" id="A0A401GRF1"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="346" mass="37105" checksum="16F4B7DCB3CC904A" modified="2019-05-08" version="1">MSLPATTREYRLTTADGTHDINIQEASIRAPNSFEVLVKVHAVSLQYRDLLVSRNNYPLGQIPHVVPCSDMAGEVVSVGDEVKGWSVGDRVCANFSVDHVHGPLTDELKRTFLGGGIDGVLTEYKVLPAHCLVRIPDHLSYEEASTLPCAALTAYNALLGPVPIKGGDTVLVQGTGGVSIFALQFAVASGATVIATSSSDVKLKLAAELGATHLVNYRKTPDWETEVLRVTGGKGVNHIVEVGGPGTLAKSAKCIAYAGWIHAIGHVTEDGDVSSVPMHLLARTAFMRGLIVGPRTQFENMNRLISATKIEPIIDRVFSFEEARAAYGYLESQKHVGKIVIKVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRS9</accession>
    <name>A0A401GRS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2241 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0701330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615864.1">
        <property type="nucleotide sequence ID" value="XM_027760063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRS9"/>
    <dbReference type="STRING" id="139825.A0A401GRS9"/>
    <dbReference type="GeneID" id="38781868"/>
    <dbReference type="InParanoid" id="A0A401GRS9"/>
    <dbReference type="OrthoDB" id="10064407at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018717">
        <property type="entry name" value="DUF2241"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39199">
        <property type="entry name" value="BLR5128 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39199:SF1">
        <property type="entry name" value="BLR5128 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10000">
        <property type="entry name" value="ACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2241" evidence="1">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="148" mass="15996" checksum="CFE454DBC5038616" modified="2019-05-08" version="1">MAPSVGETNLTALLATMQPVLQPDTYVFLTFPPSVQPPAMLPTTLTFAESEGTTVITTRATAEAHGLTDVHFPSRMITLQVHSSLEAVGFLATITAVLCRRKGMATNVVSAFFHDHIFVPEAKAEEAMEVLRGLVEDAQVKIAVEKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRX5</accession>
    <name>A0A401GRX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0701480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615879.1">
        <property type="nucleotide sequence ID" value="XM_027760078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRX5"/>
    <dbReference type="STRING" id="139825.A0A401GRX5"/>
    <dbReference type="GeneID" id="38781883"/>
    <dbReference type="InParanoid" id="A0A401GRX5"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019157844" evidence="5">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="120"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="313" mass="33571" checksum="DDAA425B0DA32E10" modified="2019-05-08" version="1">MSLFFTILTSLSGIASVFAFPVPVSFSEEPAALERREVTTLTSSQLADFAPYTEFARAAYCPSDIVTGWQCGEACAAVPGFEVSLTGGDGNALQLYYVGYWPQENAVVVAHEGTDPTQFLSDLTDADIITENLDSSLFPGVSSDIWVHSGFANEQAQTATTILTETNSLIQQYSATNVITVGHSLGGALAQLDALYLTLQLPSSIHIKSITYGTPRVGNSAYATYFDSMVPDYTRVNNELDIVPIVPGRFLGFLHPHGEVHIIAPDDAVSCPGDDDGTDEQCTDLSVPNILDGNIVDHLGPYQGIWIGTLFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS36</accession>
    <name>A0A401GS36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0702210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615948.1">
        <property type="nucleotide sequence ID" value="XM_027760147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS36"/>
    <dbReference type="GeneID" id="38781952"/>
    <dbReference type="InParanoid" id="A0A401GS36"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18591" checksum="7D2DBD85705987B9" modified="2019-05-08" version="1">MTVRAGKEIPWSFGWFKVQLSHGPCHGVRRRSDCRDEVWQIMDGWLLCLYETTKRGIVVRDISSRNILIRWGAPQPVEFTEFASGRNSDAIEPGETAKLYASEGGENCLRTVVVVSRLASDLPQTLSRNGFGSFRREGLDESSALMLAFGVVFGGPLERSLEILPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSA4</accession>
    <name>A0A401GSA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0702360</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615963.1">
        <property type="nucleotide sequence ID" value="XM_027760162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSA4"/>
    <dbReference type="STRING" id="139825.A0A401GSA4"/>
    <dbReference type="GeneID" id="38781967"/>
    <dbReference type="InParanoid" id="A0A401GSA4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="76"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE85050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="588" mass="63838" checksum="460D51192A71AC19" modified="2019-05-08" version="1">MADQPSKKRGFFSRKEKGDAISESQLQVVPSTESSSKQQPEEPPESANAPQSQVIQPVSFVSLFRFSTRTELTFNVIGVIAAAAAGAAQPLMSLLFGNLVQAFVTFGSTVQESKAGTLTDPGALTAAENHFRTTAAKDASYLVYIGLGMFVCTYVYMLVWVYTGEVNAKRIRERYLKAILRQDIAFFDHVGAGEVATRIQTDTHLVQQGISEKVAICVSFFASFVTGFVLAYVRSWRLALALSSMLPCIAVTGGVMNKFVSRYMKLSLAYVADGGTLAEEVFSTVRTAQAFGTQEVLSDRYNSHILLSRRVDMKAAVFHGCGLAVFFFVVYGGYALAFDFGTTLIDRGEGTAGQVVNVILAILIGSFSLALLAPEMQAITHGMGAAAKLYETIDRVPPIDSQDESGLKPEKCAGEITFENVKFNYPSRPEVRIVKDLTIQFPAGKTTALVGASGSGKSTVISLVERFYDPLSGSVRLDGRSLRDLNVKWLRSQIGLVSQEPTLFATTIFGNVAHGLIGTEHEDASDEVKMALVKEACVTANADGFISKLPLGYETVVGEWCSRSHGVVVVVYVVCEIYLLRYENGRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSC3</accession>
    <name>A0A401GSC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0702550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615982.1">
        <property type="nucleotide sequence ID" value="XM_027760181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSC3"/>
    <dbReference type="FunCoup" id="A0A401GSC3">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSC3"/>
    <dbReference type="GeneID" id="38781986"/>
    <dbReference type="InParanoid" id="A0A401GSC3"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019507437" description="Dipeptidyl-peptidase V" evidence="6">
        <location>
            <begin position="23"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="542"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="758" mass="84421" checksum="4DED53FE5032D0A6" modified="2019-05-08" version="1">MRFLQAFPFSLLGLAAQIPVEAPVKLTDTIMSARPDFTFKEGSAVFSPKDLIELARPGTGVANALGDLALVPISKYSLDEKKNYKSIFIAPIESTVQPLEIPLANGGDAFWLDSRTVAHAVVEGEDNDKVTSLYALSVKFKTEPSADILSVPDSPALIGKFPTATAQNFKLSVKSGVLVFSDLVHADGDITAVKKNDEAWENRGDSAFVYDETYERHWDTWAGPKRPSLFSVKLAQSPDKKWSLGTEYVNLLNGTGHYCPVEPFGGTEDFDVSETHVVYTVKDPELPASWHTKQNVYIVDLSGQSKPRELTTGKFGATHSPIYSPQGDKAAWLQLDNDGSEADRAKIVIHDLTKDVQYTLTQHWDRSPEAIIFSDDGRSLYITAGEHARVKVFVLPVPPTPESYTTDPAFPPEYRNPLALTSTGAATAVQPLPNGRLLFTYSSLTSPNDVYALRGLESLDLHSSTSRKTFKGKIERLTRFAENDLKEKSLSAGEDFWFEGALGKQVQGFILKPPGFKEGEKKKWPIVLLIHGGPQGAWEDQWSTRWNPNIFAQQGYFTVLINPTGSTTFGQEFTDAISGDWGGKPMEDLRKGWAYILNKFPEIDADRAVAAGASYGGYAINWIQGHPEYGFGFKALLCHDGVFSSAYNGYSTDELFFFNHEWSGRPWEPEAKATIAKYDPANFVHRWSTPQLVIHGSKDYRLPETDGISAFHALQQLSVPSRLVIFPDENHWVLNHKNSLKWHYEVFRWFDKFVGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSI0</accession>
    <name>A0A401GSI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0703780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616105.1">
        <property type="nucleotide sequence ID" value="XM_027760304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSI0"/>
    <dbReference type="STRING" id="139825.A0A401GSI0"/>
    <dbReference type="GeneID" id="38782109"/>
    <dbReference type="InParanoid" id="A0A401GSI0"/>
    <dbReference type="OrthoDB" id="3227715at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="225" mass="24629" checksum="C3003315A1B78161" modified="2019-05-08" version="1">MTYAFERAVTCAHFFSCPFLSSNDIHRQMPQAQQIQAFGPQYAGPVLRAPSPSSSIESADHQDETSLSDSELSPYDFAMKWDKKIRLNDPRPDEEAANKEPLLLPRPKTAAEEKLLHERVMINLREQVRLLEDESLFEQTVLRGSKVGLEQQPSTNDIDEIMHSLMSPSTSIGSAAIIQRAGSSGTALSIGNARTRSQDTAGGNGTDSSGTTVDKRPTKGKGKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSN3</accession>
    <name>A0A401GSN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0703650</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 15">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion outer membrane</location>
            <topology evidence="2 15">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616092.1">
        <property type="nucleotide sequence ID" value="XM_027760291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSN3"/>
    <dbReference type="FunCoup" id="A0A401GSN3">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSN3"/>
    <dbReference type="GeneID" id="38782096"/>
    <dbReference type="InParanoid" id="A0A401GSN3"/>
    <dbReference type="OrthoDB" id="10020961at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001330">
        <property type="entry name" value="Mitochondrial Rho GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 15" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="2"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="186"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="18">
        <location>
            <begin position="415"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE85179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="646" mass="72221" checksum="EEC79074534F77D9" modified="2019-05-08" version="1">MRRDVRILLVGDEGVGKSTIVTSLIKESFVAHVQHVVPEVTIPPEVTPENVTTYIVDSGSGPQDRPHLESEIRKAHVICVVYSIDNPNSFDRIPAYWLPYFRQLGVNVPVILVGNKIDLRGGEVTNEALEDEIVPIMNEFKEVETCVECSAKLPLNVSEVFYFAQKAVLHPTAPLYDSRDHVLKKECVGALRRIFKLCDINKDGLLDASELNEFQRKCFDAPLQLQELEGIREMVREHAEGGVRDGGLTEAGFLYLHTIFIQRGRLETTWTVLRKFGYGEDLRLTEAFLYPKFDVPHDCSVELSPLGYQFFTDIFETFDKDQDGALKTEELDDLFSTSPANPWAGQKFPDTTVADDTGAVTLQGWLAQWSMTTLLDHKTTLAYLAYLGYPGEPRTSALHVTRPRKVDRRKGKVTRNVFLCYVCGAAGSGKTSLLRAFAGKLFSEIYEPTKKMNSVVNSVDIDGSEKYLVLQEFGSKYEAEMLRNPKKTDLADVMVYVHDSSDTNSFSYISNLRQQYNLDHIPTLFVATKSDLDLAQQRHEVQPDVYCRRLGLQVPVAVSVRTGQTADVFHAICSIAMKPNNALPGGSDRALTAAARLRTYITVCTLIGGLATGLVLVYRTFSRPGGPSWGWGQWASWLLGSSRKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSU1</accession>
    <name>A0A401GSU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0704400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616166.1">
        <property type="nucleotide sequence ID" value="XM_027760365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSU1"/>
    <dbReference type="STRING" id="139825.A0A401GSU1"/>
    <dbReference type="GeneID" id="38782170"/>
    <dbReference type="InParanoid" id="A0A401GSU1"/>
    <dbReference type="OrthoDB" id="3266963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="313"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="879" mass="98912" checksum="0331935C955B7543" modified="2019-05-08" version="1">MFTSRHSALTPVRNNVRRESANGSPAEESTTGSQLTSQVVRGEGKAMARKRLQEWAIGKVEEILDCEAAEVSAKGGGFHLKDKDATWEFVLNFSMQKMMSLYESKAPTIVRLLIACAIPSEARPVISPERVTSSIPHEQNQSSAVNLPVSYADYLMRNAPSGRGKNRKDPLVTVLTACLLLMSARNLHSTAFRKVVGVWLFAHTAHHGLYSILSRLGFSVSYTSVLKLLRRLAVSAKEVIQRKSTSRAFLLIYDNINRMKRAWDPDLGQKDAIHNGTAATYVELEDCDVEKAFDVKALRESQQQERRKQLDLGVLYKRINWMKLNATMATHILAILIEAIPALSVHLPLLRIRFETTLMIHRMRKGRKTGLYPMATSDYNEGNTAENAKVLEDLLVEQLGMPKEEIEKMLVIIGGDQSTVEKLQTLKRYVTTCPHGYSRHGWVLPLIQLWHMGWADLERVLNTHWGVSTADDLSSFRSANVLLGRKVKDQRRPDYYPTQRLIFDTLRAEVLDCWRIELDVADLHEHFHPQASSFEDLLKHANNIFDRYLTVDGYTHALDPMEDPQGVFATGDPWAAHAEGDTETGNSGPSFRGDQVLANTILRMRDSMLHYEFQCAIAEGDIGRAMNVMSVWTFTFAGSGKSKYTNELLELTCNFEFEYSDELKKAILNNWLCNLSGIEGCWFPMDLMQEKNIKQLKKMSQRADVTFGGPFFRDVIALNIRAFLESMASMKAGVRLLDHGGSHRRDQKEAAMKELARHIAEQGLHRFRVGRTSTHAAQDDFEVGYQRLVDGKRIKDFVARTLRDAGAIHGDEDLDTNAVASNPDITSGREDSDIPSLPSVLVNGQLIHGAAELEQDHEEYLLWDSDDSTTESESGDESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT72</accession>
    <name>A0A401GT72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flap endonuclease GEN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616296.1">
        <property type="nucleotide sequence ID" value="XM_027760495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT72"/>
    <dbReference type="STRING" id="139825.A0A401GT72"/>
    <dbReference type="GeneID" id="38782300"/>
    <dbReference type="InParanoid" id="A0A401GT72"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="269" mass="29626" checksum="590327B6F4F4C3EE" modified="2019-05-08" version="1">MRYGLGESLCDAAMVLGNNKTELSAFLSGWRDRLRSILSTDPDNHLGHHHIALSNSVPDLFPDVAVLRAYLSPSTSANIPHLPAHPLPVDLAKLSTFCELHFGWRTKSGIIKHVREWLWPGMALKLLVAEAVAYDRRHQKQGAHSTLAAPPLEVWLQPDHSTDQDNVRVIAIDCSSADIAISNLFGVRLSPHPSGTQQLNYSARPLKLWVPSTIVHHARACSCGVDPSTFSDVINLTTSDDDDDDVEQQEVISLIMDDPVVIDLTIDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTK0</accession>
    <name>A0A401GTK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar protein-sorting-associated protein 37 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0702500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615977.1">
        <property type="nucleotide sequence ID" value="XM_027760176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTK0"/>
    <dbReference type="STRING" id="139825.A0A401GTK0"/>
    <dbReference type="GeneID" id="38781981"/>
    <dbReference type="InParanoid" id="A0A401GTK0"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="87"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE85064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="21064" checksum="DF24B5AB720437F9" modified="2019-05-08" version="1">MASTPLMAEFPELAQLSREDLEDLLVDPVYFQATFHALNQVKSLYQAQAELGSANESIARHNLALQDSLYKLRTETQEAFDEAKALEKRWKDLEKEQKEVYQRFSPQFLLMRLRHATAAQDDLSEARASAFVQGSTEEAASSLSGKDIDDFVREFKELRKVYHKRMMWGDRWAAGQVEWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUR8</accession>
    <name>A0A401GUR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Transposon Tf2-9 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0804990</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616888.1">
        <property type="nucleotide sequence ID" value="XM_027761087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUR8"/>
    <dbReference type="STRING" id="139825.A0A401GUR8"/>
    <dbReference type="GeneID" id="38782892"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
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    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="259"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="813"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="1112"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE85975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1166" mass="133616" checksum="E07412EE0BE5CDF3" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGKDAKWPPKPTVEDAPDEEVSISKEDGLPELITTETSPTSFGHSESIREIMADNTERGELPAVRNDTEPDDPPSEPPMDQLDDDDLVISYIAGEPVIGIFEPIKKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKLKTVEELVPNYLHDLKSVFEKKAAEHFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLQKGYIRLSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNNLEEHHVRTRHVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGDLHPCAYISQTLNPAERNYEIYDRELLGIIRALAEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSHRNGLDDSESDNEDRVLLPNALFVRSISPTLFDEIRNHAAKDLIVHEALEAIAHKGPFPMKSSLSDWEVRDGVILYKGKIYVPPSETLRRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSQFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQMDGETERVNQELEIYLRLYCGNNPETWADRLPDLEFCHNTREHSARKMSPFRIMMGYEPRGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYVNPPPDVVDNEEEYEVEAILNHKTYRGRLSYLVKWKGYSSAENSWEPTHNLQNAKRILDAYKRTRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV52</accession>
    <name>A0A401GV52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G-alpha-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0806410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617030.1">
        <property type="nucleotide sequence ID" value="XM_027761229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV52"/>
    <dbReference type="STRING" id="139825.A0A401GV52"/>
    <dbReference type="GeneID" id="38783034"/>
    <dbReference type="InParanoid" id="A0A401GV52"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="145"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="480"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="61899" checksum="1C8BC5208FBCBCD1" modified="2019-05-08" version="1">MASKLFSAAAEAAGVAGANDDPLARVLAPPADETAEARAARLERAVEAQRVSHEIDEDIQESKKAFERRKKAIKILLLGQAESGKSTTLKNFQLAFSPQHFRSERAAWRTIIQLNLIRSVKRLLEVLDEEWDSELTAPVKSALKSAPSSPTASSSSPRAARSRSGSRSGSPSRTRPPQSIALPPSALANPAAGSSRAHAIAHPHASTSAASSSHHPAPSFLPPSSAPRHASHPSTSTSVRFSTTPLTDTHRRLRGRLRVLLPLEAALARALLPPDDAVTGPAGDVCVRAGSAWKGAASVLASSGLAVNGVNLPNGKGKEHVDDPTRTLAACKDDVVTLWEDPVVRAVLKRRGVRLQDMPGFFLNDTARIATLNYQPTDDDIVRARLRTLGVEEHRFTMESGGLPGSEWYIYDVGGSRSNRPHWIPFFDDVQAIIFLAPLAFNLMLEEDPRVNRVEDSISLWREICGNGLLAKTTLILFLNKMDILQATLAAGIRVAKYVPSYGDQPNDIQHVTKYFRDKFRGYHKRLSPHTRPFYVHETSVVDTRSTAAILVGVREGILRAHLQSVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVD2</accession>
    <name>A0A401GVD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">3-ketoacyl-CoA thiolase, peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0900690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617104.1">
        <property type="nucleotide sequence ID" value="XM_027761303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVD2"/>
    <dbReference type="STRING" id="139825.A0A401GVD2"/>
    <dbReference type="GeneID" id="38783108"/>
    <dbReference type="InParanoid" id="A0A401GVD2"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000010">
        <property type="entry name" value="Acetyl-CoA acetyltransferase (Thiolase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="293"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE86191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="415" mass="42613" checksum="B4797DFCABB72372" modified="2019-05-08" version="1">MSSFAQRISSFTTTSPKAKILAQHDDDVVIVAAVRSAITKAKKGGFKDTRPEEILSGIFRAAYSKAGLDPRLIEDIAVGNVLPPAGGASAARMAALHAGIPNTVPINTVNRQCSSGLTAINHIAAEIISGQIDIGIGAGVESMTFGFGARAQADGFSEAVLSTQEAEDCLIPMGITSENVAADYGITREVQDAFAASSFQKAAAAQSAGKFAAEIVPLEVTWVDPKTERETRVVVDRDDGVREGVTAASLGKLKPAFKADGSTHAGNASQVSDGAAAVVLARRSTAARLGLPVVGKFVAAAVVGVPPRIMGVGPAYAIPRVLEKTGLGLADVDFFEINEAFASQAVYCVQKLGIPVEKVNVNGGAIAIGHPLGCTGARQVATGLNISKQTGAKVFCTSMCIGSGMGMAAIFVSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX31</accession>
    <name>A0A401GX31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 54 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1000270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617698.1">
        <property type="nucleotide sequence ID" value="XM_027761897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX31"/>
    <dbReference type="STRING" id="139825.A0A401GX31"/>
    <dbReference type="GeneID" id="38783702"/>
    <dbReference type="InParanoid" id="A0A401GX31"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049546">
        <property type="entry name" value="WDR54_beta_prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21031">
        <property type="entry name" value="WDR54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WD repeat-containing protein 54 beta-propeller" evidence="4">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="263"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="346" mass="36676" checksum="813C79EBDA0EC479" modified="2019-05-08" version="1">MDRIFRTTGGVTSLACAADGVVVNGSEEGTLTLWDAERGRQLAVHKAHTDAVCAIGVSPDGRALLSAGRDKVVHLWDLNPKSEGGAVVRGQLEGHEDFVVAIAWTPDGRTVVTGAVDLTARLWDVKTRETTHVLRGHTTMIMWVAFSADGQRVATAAADSTSRVWDVASGAKLSVLRGHESVVYMVAFSPDGRRVVTGGDDGTARVWRAETGEELVTLREHAGMLHHAVFSEDGKRVLSVGSDGVVKVCDSFGAEVLRSIDATAGTNDGLNAGVVSRDGKLACTAASDHVVHVWDLDTGAAVAAFEGHEDSVQVLIFSPDGKRVVSSGDDGTMRIWNVEEKMVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXT2</accession>
    <name>A0A401GXT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1002630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617930.1">
        <property type="nucleotide sequence ID" value="XM_027762129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXT2"/>
    <dbReference type="STRING" id="139825.A0A401GXT2"/>
    <dbReference type="GeneID" id="38783934"/>
    <dbReference type="InParanoid" id="A0A401GXT2"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="867" mass="98434" checksum="6EBDCE42C2D8C080" modified="2019-05-08" version="1">MTSTIDPSTIGKPPQRARRHVRTLTNFLPETDETGKEKWPRGDETVWKAAIRGVDTDVPSITKSVVNHVQTSLARQAYNLDDLGAYQAAAMSVRDDLIVNWNETQQHHSRKSQKRAYYLSLEFLMGRTLDNALLNLGLKDKYATGMNQLGFNLEDILEQERDAALGNGGLGRLAACYLDSSASQELPVWGYGLRYKYGIFQQLISPDGGQLEAPDPWLEHDNPWELPRLDVIFDVRFYGHSERLGNGRAIWSGGQEVLAMAYDVMIPGYDTKSTNNLRLWESKPKRGFDLNSFNAGDYERAVESSNSAAAITSVLYPNDHTGFGKELRLKQQYFWTAASLADIMRRFKNLDKPITEFPDYVAIQLNDTHPTLAIPELMRMLVDEEEVPWDTAWQIVTNTFFFTNHTVLPEALEKWPVPLMTTLLPRHMQIIFDINLIFLQAVDKKFPGDREKLAKMSLIEEGFPQSVRMANLACIGSRRVNGVAELHSELVRTTILKDFVDFYGVSKFSNVTNGITPRRWLDQCNPSLSNLISETLKLPKAVFLKDLYKLDGLLEHIDDPTFQKKWAAIKQSNKERLAHHIETTLGFRINTHAMFDVQIKRLHEYKRQTLNIMGVIHRYLTLKDMTPQERTKVNPKVVFFAGKAAPGYYVAKLTIRLIVNVARIINIDPDTKDLLTLYFLPDYSVSLAEVLIPASDISQHISTAGTEASGTSNMKFCLNGGLLLGTVDGANIEIAEEVGESNVFFFGHLTPAVEDLRYQHTYHAVPIEEKCPALARVLDEVAAGRFGDGSVYEPLLNTIRQIDYYLLTEDFDSYIQALRMVDDAYKDRVEWIKKSIRTTAKMGKFSSDRAIQDYAQEYWNIESTKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYY8</accession>
    <name>A0A401GYY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1100450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618283.1">
        <property type="nucleotide sequence ID" value="XM_027762482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYY8"/>
    <dbReference type="STRING" id="139825.A0A401GYY8"/>
    <dbReference type="GeneID" id="38784287"/>
    <dbReference type="InParanoid" id="A0A401GYY8"/>
    <dbReference type="OrthoDB" id="3095164at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="619" mass="67950" checksum="0DA41BF811D20997" modified="2019-05-08" version="1">MADSSIEVILQKHISWRLVELTVLDEKHAEYLSHKLGSEERTAILKAAVAALQNVSPRFTRAALPMAHEKVQVFFKNTRMCISKGVQCEFHAGGKNMFIARKCSSGGSALWAKDDEGRKIWEAALTSQVAEGKVNKSNCTAVISSVKSKCFKALSDEEKHTWEEKAEELRKERENLSVDDLIADNQEGLFVKVASALQGLIGSKGWQAGEDVGFHLRMVYKPREGVPRSTRVDIMPTGETESFSTFEGRNEAEDACWERFMARVFVVNRDPPRAPDDIGKPVLPQIEKDWTPMHVGKTLKEYMEELWLYTHTDVEDLPELPWDTLGDIACELVAADWQGSVGDPMKPAQVMALYLRMYDAQDTDGSFSFVVDLAAIRRCTILDNGNILEGPSVNEMAIAPDGDAIIADGDAIAPDGDAIAHDGDATDKEKEEEEEKEEDDDDDDIAQTPSRKRVVVSTSTYVDDDGEPLDPDNISMRALKHSATETVVTHGEHTVNKGKGVAAAGDAVGVEVRHEGDKVVAGREDAVDGQRADGVCKRDDESDADAEGEDDDEEDGGSIKEVVKVMRGRKRKQGPRASTSTSNTKAAGRAVNKKCCVAVSVVEKRCTCATHTFQSCYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZB0</accession>
    <name>A0A401GZB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1101800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618416.1">
        <property type="nucleotide sequence ID" value="XM_027762615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZB0"/>
    <dbReference type="GeneID" id="38784420"/>
    <dbReference type="InParanoid" id="A0A401GZB0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20883" checksum="5A8D7AB68F4BE635" modified="2019-05-08" version="1">MESVSKWMNAEYRQAGNLESLVESNKDLRVVLRQAKEEKDLRHSMLDDEAIPLRPLRLGASLELVKSVWSDEGHKTLDNSVLRLTKSIPFEAIEEDPEVAALLLHPVLSFVESVSKWMNAEHREVGNLESLVNSNKDQRVALRQAKEEKDFYAFRCLRILRKDRTPTPWDGKSVPKQGVEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0A5</accession>
    <name>A0A401H0A5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1200450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618733.1">
        <property type="nucleotide sequence ID" value="XM_027762932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0A5"/>
    <dbReference type="GeneID" id="38784737"/>
    <dbReference type="InParanoid" id="A0A401H0A5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="33780" checksum="73D3D6755BD930F8" modified="2019-05-08" version="1">MRRPRGPAVGTPIPRLADHKTCAPPAHAVSSPLWLRFRDRARLDHHADLPACQHQSRAELLAKHAHPLGPNTAPRPTQMRVPTARAIRRAFAAPLHSTSTADTLHHLHSRQCDHHVDLPLERQYRAWPTAKHAAPLRAPPPRLSPSHFATARGLTNTRTSRRANPNAAPSPSHNTRTRSQCQHGASPDQNARLDCARNSARVCAPLHSTSTANTLHHLLSPTGPPRGPPVRMPIPRLGHRKTRAPAARAATSTLSLTLRDRAQVDHRPDLPFERQGRTSPLAKHAPALRTQFPPHSRPRFGTVPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0K1</accession>
    <name>A0A401H0K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1201810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618868.1">
        <property type="nucleotide sequence ID" value="XM_027763067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0K1"/>
    <dbReference type="GeneID" id="38784872"/>
    <dbReference type="InParanoid" id="A0A401H0K1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="184" mass="20560" checksum="64F13F5A8CD57432" modified="2019-05-08" version="1">MFASTSAVLVEHCPRPIEEPHVKEDTPALPFRHFVPLPNVDAAPAPWCPAENIVFIRNGRTVLGPEMSLDELVCDMPIKGGFDPVLLTARGGTMRLLLHWPGYLHEKFQEIQVIRPDGRPIKKSQLGQMVARHYIEFLNGIPPEECVDKNWLMEPARKNPRNVILGSVDNPAGDILVAQLYVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Z8</accession>
    <name>A0A401H0Z8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619020.1">
        <property type="nucleotide sequence ID" value="XM_027763219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Z8"/>
    <dbReference type="GeneID" id="38785024"/>
    <dbReference type="InParanoid" id="A0A401H0Z8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="429" mass="49664" checksum="D375AFC6CA98149D" modified="2019-05-08" version="1">MLTDAKILHAAVLREVPSTDKEVLVRRIFTEYIMLPLYERPLAQTFTHVDLTTYKMFVEKLNDTMGRPPRVWYDREIQELYIKFPLDIHQDIAQVFAHCFDHSLLSSSDGQVLEPQGGSEILVKGGKAEPDILLKLKTPHHRIIRGSMERISERRELILVEVAFSQSWHTVSSQVLCLLTEKPDFLGAIIVDLKEFPSWSLPSMPNGYHTHHYQASDFYVRNASKEYGPVSVDGVAWFGTLNADIYVFRNIGEEVQELHQLMSQDYEVRKTHAYCQNLTYKRPLTQTEEGDRLTAEQYSRQITSSERLLLLLDECRCVIKEEKQRQVEDGETPNLKKDNLYQNLLDPFEEEEEEDDNNLGTASMSAATTGYFLPMPPLPKASWMEEDTLAERILKLEPFWKFLRIRILEAMGSTAYSRWLSWHTNASIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H140</accession>
    <name>A0A401H140_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1203770</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619060.1">
        <property type="nucleotide sequence ID" value="XM_027763259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H140"/>
    <dbReference type="FunCoup" id="A0A401H140">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H140"/>
    <dbReference type="GeneID" id="38785064"/>
    <dbReference type="InParanoid" id="A0A401H140"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="15">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="13">
        <location>
            <begin position="168"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="14">
        <location>
            <begin position="437"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE88147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="581" mass="63262" checksum="FBCC1C3BEB36686D" modified="2019-05-08" version="1">MAAQLPIPVFTSLNEIHTDLQTAALQATRWDNLVQEFEKRYGTKPAYICRAPGRVNLIGEHIDYALFGVFPAAVESDILIACGPSTDERLGGVTAENLNPRYTRQTFAPILKNTLLPSAQGTEAASNEESWFLEIDKKELRWESYVKAGYYGILNRFFPPSAPNTRPVPVNLLVTGSVPSGSGLSSSAAMVVASTLAFLAVNDKLSGLTKGQLVEMDMENEKRVGVNSGGMDQAASVISIPQSALYITFFPSLSAEPIPLPTPRTTPRAVFVCANSLVVSDKVVGAKTRYNLRVVETLVGARVLALRLGLSLGPTERPTLREVFGRWLGIAETKGGPSTLDVETLRAGLERILPEVEKLKPSRADGQEGLTLEEMVQWSGLSPEQFHELYLSWVDVEATHFQLYKRAKHVFSEALRVLQFRDVCLRAAASSDTTLPESTLVELGVLMNASQTSCADLYECSCPELDALTKLAREAGAYGSRLTGAGWGGCTVSLVAEDKVDEFISRIKAVYGPYKNLEGDALHDAIFATKPSSGACVYKPALATILYPEYFETVKVDWTVWTQSGPVRYSCGSEAEQKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1C7</accession>
    <name>A0A401H1C7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1204110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619093.1">
        <property type="nucleotide sequence ID" value="XM_027763292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1C7"/>
    <dbReference type="FunCoup" id="A0A401H1C7">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1C7"/>
    <dbReference type="GeneID" id="38785097"/>
    <dbReference type="InParanoid" id="A0A401H1C7"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="137" mass="15086" checksum="BECB47ED9991CC52" modified="2019-05-08" version="1">MQLLTESHHSMATDTLLKYNDILICSILCEQRQLKDLLQTTLNAADQDPAANNLKMSTVLLYQTAILCNKRCLLAYHHHHLERLKDLYWSVGDALPLLLSMPSASASQNVNASGNGSSGPPCFPHFTNYNAPTSGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1J5</accession>
    <name>A0A401H1J5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1301220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619220.1">
        <property type="nucleotide sequence ID" value="XM_027763419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1J5"/>
    <dbReference type="STRING" id="139825.A0A401H1J5"/>
    <dbReference type="GeneID" id="38785224"/>
    <dbReference type="InParanoid" id="A0A401H1J5"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="255"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="418" mass="43979" checksum="A5CA835EE2101AB2" modified="2019-05-08" version="1">MSQHLLTAAESRLFNGFLDHHAHDSVEWRGFHPALADKIPHKQGKEALARATKELLSFGAANAPLSSKAATAAAGGSSSGGAIASLSASASAKTGGTSRSGSGVSHWPSFTPDAHDPARSNHGRYDRHSPYSFSSYRPQQQQQHDQPTSSSSAFTLASLNVSARPSVPPSSASTSKRALPRDHQVGGSISSAGDGTVAKRARPTPPEDTSAPILPANTPSAAAAAPAKARRPSQSARRSAVPAAPSKPALLSPSQKRANHIQSEQKRRANIRRGYEALCDAVPALREAIRLDDEASAADASTNANASSASGGGREDKARKRKRRGEDEKTADGRAGPRSENVVLSKTIEYIRTLLNDRQDLVTRLTFARSVLAPEHPALTVSTAHADEEGIPLWEREWKGGSGAADEDEGEGGSEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1N6</accession>
    <name>A0A401H1N6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1301600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619258.1">
        <property type="nucleotide sequence ID" value="XM_027763457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1N6"/>
    <dbReference type="STRING" id="139825.A0A401H1N6"/>
    <dbReference type="GeneID" id="38785262"/>
    <dbReference type="InParanoid" id="A0A401H1N6"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="169" mass="18728" checksum="01BB41824D14F944" modified="2019-05-08" version="1">MSVTLHTSLGDIKVEIFCEAVPKAAENFLALCASNYYDNCLWHRNIKGFMIQTGDPSGSGKGGQSIWSRPFADEIRSTLKFNNRGILAMANSGPDTNKSQFFITYAKQPHLDGKYTIFGKVIDGADTTLDAMERVPVNAKNRPLNEIRLTHVTIHANPIADAQLTSRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H250</accession>
    <name>A0A401H250_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1303330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619430.1">
        <property type="nucleotide sequence ID" value="XM_027763629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H250"/>
    <dbReference type="GeneID" id="38785434"/>
    <dbReference type="InParanoid" id="A0A401H250"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019523964" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12455" checksum="EED36661FD39BF57" modified="2019-05-08" version="1">MHVFGRWWSQAPFILIIRFHLQGLLAVEEVGGDNGQNINCGGVILIPSLERFQPIRATSARGGPDAFRYFSSYVPAQNFFLNMSLTVLAGSERLIYRAVRRGLVGGCGVPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H363</accession>
    <name>A0A401H363_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1402360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619742.1">
        <property type="nucleotide sequence ID" value="XM_027763941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H363"/>
    <dbReference type="STRING" id="139825.A0A401H363"/>
    <dbReference type="GeneID" id="38785746"/>
    <dbReference type="InParanoid" id="A0A401H363"/>
    <dbReference type="OrthoDB" id="3225069at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="531" mass="60286" checksum="C97B16F4A9E7B2B0" modified="2019-05-08" version="1">MSCKHPQQVEIKVIIGELRRQTADLQKLRELLIRLIRSSPGYTEVIREAVESCAERVNCDDGHSKVVYELIYKLRHTDESLRRLDWKITELEALLAPMQYLPDTLLLAIFKAGCRQPRPEPDVWLPFPMLVASVSRRWRNLTLTTPTLWTNLHISMEGPRSWASLALTRSATHLLDITIDGRVESTSRLEEIATHGHAEAPRRTPTIVSRLNLLVPHSNRWRKFTVITHHSIDIKVVGEIIKNVQSPFLEHLRLSLTGSGPAGNQEVPLPAILGGGAPMLSAVRLDSVSLPWRSMPLSGLSAIDIRWMWDRTKLMYPQFRDLLADSPSLQRLILRGRHVELRPSSTYESIHVPSLRYLELSGDNICRLSSILITPELETLALVNVDESEFREFVGSLSSVKIRYSALRFLIFVNVTTCDLSSGFTEAFPNIVQLTIINSHANHFVELMLRKHDSMYPGPDTGIWPLLNTIVLIADDVNYDRLRQMLLKRTAEQLAVQRLILNGIYTHNHQYVSPLMDLVKVDGISVLEGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3L4</accession>
    <name>A0A401H3L4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619949.1">
        <property type="nucleotide sequence ID" value="XM_027764148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3L4"/>
    <dbReference type="GeneID" id="38785953"/>
    <dbReference type="InParanoid" id="A0A401H3L4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="117" mass="12639" checksum="51C1C7879A337BEE" modified="2019-05-08" version="1">MQAAQEDAVLFASDVALDTLDDHTLFGDDGSIDERRLFEAAYPVVRLPIRSCESESIGHGASSAGNSPSPPHNVGGYETIRPFSTWPLYTGSPTISLPQTSVTHHVHLRSPRSIVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3R9</accession>
    <name>A0A401H3R9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1500670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619977.1">
        <property type="nucleotide sequence ID" value="XM_027764176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3R9"/>
    <dbReference type="STRING" id="139825.A0A401H3R9"/>
    <dbReference type="GeneID" id="38785981"/>
    <dbReference type="InParanoid" id="A0A401H3R9"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="293"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="105"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE89064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="410" mass="44717" checksum="7965C9B7FA7F93B2" modified="2019-05-08" version="1">MIPMSYPYHYVDYSNPTTPRVYTWDIEQDAAQAVQPQSFHVQDQQQQQQQHQEHAQPQPQLEDTRQQSQRLHQTVFQPPTIQLQERRVPSQYRFDNITEEHFLQAATVDETRSETSSRRGASKPPLHVTKAERPSVSPTASSAGAGPSAMPARVAHGRHVQHAHPYRRPSSAASSSGARGAPTSVRVRRESEMPHPMMPSPQAPASAEEQAQLHPSTSAAGSAGRNLNTIASAAAISAMAVSCPAAQLWRDKLLRGPDNAVGGTSPALGGMPTPAQAQAFPGIRTPEPPRRYTIRMDVQFDAADDAADNMLTAMLELPGVRKADLRLTLATCPYSRVRQLTIAGTVRSTLTPRGHTVQERKFGEFARTLVVPPETKSDDVHAVMEDGILTLKIPGGHPAEAEPPQEIAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4B4</accession>
    <name>A0A401H4B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1502940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620199.1">
        <property type="nucleotide sequence ID" value="XM_027764398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4B4"/>
    <dbReference type="STRING" id="139825.A0A401H4B4"/>
    <dbReference type="GeneID" id="38786203"/>
    <dbReference type="InParanoid" id="A0A401H4B4"/>
    <dbReference type="OrthoDB" id="2747634at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="96" mass="10929" checksum="73574CBCAD2174A1" modified="2019-05-08" version="1">MPKVLHALRRMLAAPRFLAHEPVRVYAVALRYGLEDLAREAAAHALRFPVDWPNYEEFKDVSEYDYHMLLSLHRERARGAVACLAHPSVLTSLGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4Z2</accession>
    <name>A0A401H4Z2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1601780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620429.1">
        <property type="nucleotide sequence ID" value="XM_027764628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4Z2"/>
    <dbReference type="STRING" id="139825.A0A401H4Z2"/>
    <dbReference type="GeneID" id="38786433"/>
    <dbReference type="InParanoid" id="A0A401H4Z2"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="264" mass="28352" checksum="FCDF2D222944EE67" modified="2019-05-08" version="1">MSTSAAPEIRIAQIKGSIPTCTPNLMPFHIAYAGPAPISTYFRVKPAPPLTYGKEATPRITPSSSGDSTPPSADAQTASGSSQSTLVASSSTASIPATSVTSLDTAVDVEMVEEGNSLLNTSKRFVAAFRGRIMQGLTVELPQGYAGIVLRTPDDGKDKHAGASRDVELEREKARDKGKKAGKRSTRRSRATEVDPGEDGDTGDFNMEAAWDHDAPSRVLEPTSSFSSFVLWHPDIPVDEGKDEYLRSLTDWTRLAAEIHRCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H571</accession>
    <name>A0A401H571_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1602050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620456.1">
        <property type="nucleotide sequence ID" value="XM_027764655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H571"/>
    <dbReference type="STRING" id="139825.A0A401H571"/>
    <dbReference type="GeneID" id="38786460"/>
    <dbReference type="InParanoid" id="A0A401H571"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="234"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="552" mass="61772" checksum="50ACAA45E9C1D7B2" modified="2019-05-08" version="1">MESSRPASPVTLTPQWAQRPFDNPAANIILRSSDNIDFCVHSVILSEASPFFKDMFSLQQPLVDHNKPEGLDDYRDGRPVIVVGEGSRTLDSLLRLCYPIAGPKIQALTEGPAVLEAALKYQMEEATGIMSRALMMFAADQPLRIWAIACRLRLEGEARYAARFTLTRSIFDDFPKEMQEVTAGPYFRLLKYHRLQGNVGVHFTFLSPNSPKHVSQSSQVTDSSSLDFVGYPFADLICRSSDGVEFLTHKVILSIASPILHTLITSLPANQVDTDQTLSPNNLPILSLEENGRTLTALLKLCYPVEESSTKIDDFSIVQSVLEAAKKYDMARVAPVVRKHWASLADAEPLRAYFTAVQHNFDECARQSAKNVLEGPIENAYVSEMEDAPAQAYYRLLRYYHACQDILTTAFTQYGDKIKKKNELTKEEIFDHSCSCNAPATEVRINLPDSLKEYATGQSYSVGSKYVKMRFGCTCKWKGWFNQHFASSAQLWHDSPAKARSCDSYVTNLLKTSVDNSSWCSSCRPLAERFADFARDIGSSVNGRMAQVQLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H607</accession>
    <name>A0A401H607_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposon Ty5-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620788.1">
        <property type="nucleotide sequence ID" value="XM_027764987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H607"/>
    <dbReference type="STRING" id="139825.A0A401H607"/>
    <dbReference type="GeneID" id="38786792"/>
    <dbReference type="InParanoid" id="A0A401H607"/>
    <dbReference type="OrthoDB" id="10627491at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="67"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="563" mass="63892" checksum="E4FBACC692B6264B" modified="2019-05-08" version="1">MHDPEADEDLDNDPDKSNAELVYIAMSAHGNSDADEPKTLSDAKRSLEWPKWEQAVQTELNQLQGMETWELVEPPEDRKPVGNKWVLVKKTNKEGEIIKYKARLVAKGYSQIPGMDYTETFVPVVRLETIRAILGLAAILDWEIGQMDVKGAYLNGTLKEEVYMRQPEGYSDGTYRVCKLKKTLYGLKQSGREWNIVLNRKLLDARFKRLFSDPCAYIRIKGDKIEIVTVWVDDLLIFTNDCALMDQLKRELRNMFEVTDLGEPRKIVGIEIERDRSKRTIKISQTKYIESILHKNGLTNANTVGMPLDPNTVLEKEEPETDDECDRDNGYASLVGSLMYAAIATRPDIAHAVQRLSSFTANPGMAHWTAAKRVLRYLSGTRELGIIYGPIADVKPEDQSIFVGYSDADYANDIRDRKSISGYLFKLGNGTITWSSKKQTTVASSTTEAEYMASAEAAKEAVWLRTLFKEIGFEQQDPTILFEDNTAAISIARDPQFHAKSKHFDVKHHYVREKLRDKYIDIHYCPTEDMIADILTKSLPKPRHEKLTKKLGMPIGLRGSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H624</accession>
    <name>A0A401H624_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620809.1">
        <property type="nucleotide sequence ID" value="XM_027765008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H624"/>
    <dbReference type="STRING" id="139825.A0A401H624"/>
    <dbReference type="GeneID" id="38786813"/>
    <dbReference type="InParanoid" id="A0A401H624"/>
    <dbReference type="OrthoDB" id="2802364at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="321" mass="34707" checksum="DA32247BFA6D4977" modified="2019-05-08" version="1">MQASPRQRSPRSPFLPLSPSSPPDPASPSRSLLQPPELHEPPLSSSVYPVVLKQPFDDPHEVLCHEYNVEKTTVQLEPDGTVPPTVDMQVLQDAHMPTHALVVLGSETPQPSSDSSSPTTAPALPINADQFSRKFENDIGQTSAELCVPGSTLPVPEWDAASRSQFVTLPAIPLRAPHPPSIPLLLLFGLGLHLVPQPGARRGSSRRRSASPHPRRAPRTPTGLLATFLLPTPVIEEFPAAAAMAEAMAHLCSDEEMLQYVAHNQGLWRNVLALAPTDAAVVDMVHTAWNVTAEARRIRARRRVVPPDVGNVDSEPDSDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H687</accession>
    <name>A0A401H687_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1702810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620868.1">
        <property type="nucleotide sequence ID" value="XM_027765067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H687"/>
    <dbReference type="GeneID" id="38786872"/>
    <dbReference type="InParanoid" id="A0A401H687"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="129" mass="14947" checksum="C5AD7E293E82B327" modified="2019-05-08" version="1">MDHYPRLPPYSSRSCFRYHPYPRTGRRYDRLERVVGAEYGDDTEDTILDSPPPISLLPSNVFGATSNDDVSTLELDDRVYQHDEPDAGRKQEKLRVVKQWLTTVLVVWRKCQRLPSVQAWLPSKTQSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6N5</accession>
    <name>A0A401H6N5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620985.1">
        <property type="nucleotide sequence ID" value="XM_027765184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6N5"/>
    <dbReference type="STRING" id="139825.A0A401H6N5"/>
    <dbReference type="GeneID" id="38786989"/>
    <dbReference type="InParanoid" id="A0A401H6N5"/>
    <dbReference type="OrthoDB" id="2798752at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="468" mass="53127" checksum="2434184D1BAC90D9" modified="2019-05-08" version="1">MESYENCVCGRSFSQSSAFSHHQRACQKAKKRLSDALHKAKETWSSRKKRRLEISKPAEAPASSSNTVLVQPTQVGREDVDAVNLMPPVPEVGREDVDDSNLSLLERRPWSRRLNRRLPRRFRDLLPEPAPSLPPLSVSPHKLSSLSESTSTSLMEHPVNAMSPQSHSAIESLAHRIQGFLTTPHNKFGLFRRYWTNALPSHDPEELLSLEDLSESPGAVEFANDTFQRYFPYPNATSFRLGDWYWNGGVQKSQSSFKALLDIIGDPEYDPADVRAAHWDDINRQLASDQPGEWADDDAGWNHTPVTISVPYHHRCGVSMDPQNGPKDYTVVDFHHRSLCDIIREKISNPVDALHFHYEPFQLLWQPGDVPNPIQVHGELYTSPAFIESHRELQDSPPELGCDLQRVVVAMMFWSDATHLTSFGNAKLCPLYLFFGNESKYHRCKPSRHLCNHVAYFQSVCIISLIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4L5</accession>
    <name>A0A401G4L5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="12">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0100080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608049.1">
        <property type="nucleotide sequence ID" value="XM_027752248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4L5"/>
    <dbReference type="STRING" id="139825.A0A401G4L5"/>
    <dbReference type="GeneID" id="38774053"/>
    <dbReference type="InParanoid" id="A0A401G4L5"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8 12" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="71"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE77136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="35340" checksum="4ECDB35DF39E0ECA" modified="2019-05-08" version="1">MSFPRAARTLLSSTRRYSTAPSGASKSSNLPLYLGGAGIAGLAGYLYLQSGSKAAAATPAQTQTKTPLDPERYIDLELKAIRPYNHNTAHFDFALPDNQASLLPVASCVLVQTAGDGLAIQDNKGQPVHRPYTPVSPSDAPGVFTLLVKRYEEGKMSKHIHDLKPGDKLAIKGPIMKIPYKANEFDQIGMIAGGSGITPMYQVLQHALRDPANKTKFTLIFANVAERDILYREQFDALQKAHPNTFSVVYALDKPDAGWTGAKGYVNRELITKHIAPASLGDKVKVFICGPPGQVASLAGKKDGMQQGALGGVLKELRYTENQVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Y3</accession>
    <name>A0A401G4Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608133.1">
        <property type="nucleotide sequence ID" value="XM_027752332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Y3"/>
    <dbReference type="GeneID" id="38774137"/>
    <dbReference type="InParanoid" id="A0A401G4Y3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25381" checksum="BCE4787A19CB1470" modified="2019-05-08" version="1">MSIPASPTLVNGVPSRAQTPFIRTSSPSPSIELSHASDEQEFATRLISAIRVPVDFTDILVALRNRPQDRQAVVSMQRALEMVEWMQTARQELIAAEERTSRAQTRVDQVWSLMRSTVTRTAQEIWREHGDEDIGHILGYTTNGIPASTPRSSPEPIPVRPRPPRSHVPSGRSSLSQPSFSTASTSSRRGHPYRNGRIPEQGSRTSRRTCYRCGGDHYVRDCPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G550</accession>
    <name>A0A401G550_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetraspanin Tsp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0101570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608197.1">
        <property type="nucleotide sequence ID" value="XM_027752396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G550"/>
    <dbReference type="STRING" id="139825.A0A401G550"/>
    <dbReference type="GeneID" id="38774201"/>
    <dbReference type="InParanoid" id="A0A401G550"/>
    <dbReference type="OrthoDB" id="2156690at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="419" mass="46816" checksum="1D29712C7E08AEBD" modified="2019-05-08" version="1">MWSTRYERARATSPTLPEVRLTAAEEDFDSYARTLSANSHNSPLLSSAVPYSPSTMNFPEGRIPTLRDSSSFISNDDSAHSLSINYVPSRFSSAVLSGGPKRRKNWKVGVEDVHLPKLGGGREAFRSNEPRMAAEGEDDDDVVPLPGGRTRPRMRWNRFKWILFISNTIFTVYAFAGLISCLFIWFNGWDKTDIIRVGNTTELIISTVAAAVGVFTAVVGWSGIVLNNRSFLAVYSVLLWVVFALLVTPGYITYKQRTFNLQAKLNAQWSRDLGMDGRLRIQNQLGCCGFFSPFVEATVSQTCYARSILPGCKSPYLNYERTILKRWYEAVFILVPFQILVMVVALLCSNHITYRFGKGMMPKAYRLDMNSMAVIMENYANQLAEQYGGDTASELINRSGSSLKLDVPSSSTSSFYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5G1</accession>
    <name>A0A401G5G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump FUS6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0102670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608307.1">
        <property type="nucleotide sequence ID" value="XM_027752506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5G1"/>
    <dbReference type="STRING" id="139825.A0A401G5G1"/>
    <dbReference type="GeneID" id="38774311"/>
    <dbReference type="InParanoid" id="A0A401G5G1"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="17"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE77394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="571" mass="60146" checksum="0CF1FFCDFC5216FF" modified="2019-05-08" version="1">MTEHESVPGRGWRFWAIFFSITVATFTTALDTTAVSTALPTITNDLHGSQFIWIGSAYTMSSTAFLPMSGGLAQVFGRRPTMLGSMVFFLVGSALCGAATSMNFLIAGRTVQGVGAGGITALTQIILSDLVPLRTRGTFNGLIGIAWSVASCSGPVIGGAFAENGKWRWLFYLNLFVTGLAGVLVLTFLKLKTPSGTIGQKLSKMDWIGNALVIPASTSLMIALTWGGVQYPWSSPRVLVPLVLGIVGLGVFLLYEAMLAKHPIVPFSLMSTRTGLSGYVQAFILALCLTGVVYYFPIYFQACKSAGPIASGVDSLGFTSCALLSIIGGVSVAATKRYRPQIWLGWAIVLVSFGLMSTLKDDTNLGKSIGYVILVGAGIGLVITTTYFPVLAPLPVSANAYALALYAFARSFGQVWGVTIGGTVLQNQLLKHLPEGFSSQFPQGAQIAYSIIPIIGKLPPSLSGEVRAAFATSLKVVWEVMIGIGGLGILASLLMKHLPLHTYTDDEWGVDSTSDATAQAKAVDSQESEPKMEKNTESGEVQVLDEGTSADVETGEVTADGAAASAVVETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5P9</accession>
    <name>A0A401G5P9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0103630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608401.1">
        <property type="nucleotide sequence ID" value="XM_027752600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5P9"/>
    <dbReference type="GeneID" id="38774405"/>
    <dbReference type="InParanoid" id="A0A401G5P9"/>
    <dbReference type="OrthoDB" id="4093673at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8438" checksum="3C98AF47F609A1F0" modified="2019-05-08" version="1">MLSRRIIPFLVAGITGVVSGVYIFKPLLDESSRNDVDATKLPASEPPDSPTTSSPATVNYFATKGEQAKDATPTISAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6C0</accession>
    <name>A0A401G6C0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0105980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608629.1">
        <property type="nucleotide sequence ID" value="XM_027752828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6C0"/>
    <dbReference type="STRING" id="139825.A0A401G6C0"/>
    <dbReference type="GeneID" id="38774633"/>
    <dbReference type="InParanoid" id="A0A401G6C0"/>
    <dbReference type="OrthoDB" id="3192989at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="7">
        <location>
            <begin position="255"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="8">
        <location>
            <begin position="744"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127060" checksum="8C8E544855B1B3E8" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQPPEPAIHLIKMSNLSPMPLTDQIAGVLELMFRRKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPVRLQWDIDRYYDSLSIQPTGQNEVLEAELERKWPPPFGESEIRIDQPATLVNMHGRILAWILPRVLIPDRQTKMLQANRALHPAIAASKPSSTTASWRHNPLYFLPPEECVQFPAGSLCLSPGWFQQVREHIESGRLETSASLKLEGRRSWLRDIHDSSALLGAILAVVHPTLYAAGRQCLGLIQQDPELREMALNWSSPFNALQVIANWETPFHRDSKTRYTFYDLLVTLGNYTCAWLKFPAMRVAIDYSPGTVIAFCGKAIRHGVTRADGERLVYAYFMREGVQNRLGIPAPHWMQASYYASHIGMCTRDIMPKTDGDENTMQGMETVDGSFIGGTKLAKVMVKFITDGSVWLADLEVGGDGGEMYSVEKLHNKSRLVVDLDDEVEFVTKVAKQTTRGVRYVDVPLPMPTGSNVPSPSKSPSKAPASGFLFNLDDGDVLGNIGVPIQLDPAARKTKTQNDFMRDWIPHRDDYLHAIVEMEALPEPRNCAECKVGEGRWRCLDCMGRPLTCTDCCRNSHQRAPFHRIEHWQGQYFEPASLYRVGVCIHLGHGGDPCPLGAFTAHNNPALVVAPGSDFWNASNEDLNAHDGEVSDDGEVPFNFAPLAGTLDGEARQTDDAPDPTWEEDVPSVLSRPPRRDSYGNRIIVIVDISGVHHIGVDWCQCEMAVERDMQLLQMGLYPGTVKDPHTAFTFAILDNFLLENKECKMAALNYYSKLKWVTSNAFPGTVPDRYRELMRVSCQWRQFKYRKWHGFSHDVLRPVEKGGLAIFCPACPQPGLNLPFDWQADPVQWKFKHGFVMDGNFSAEHMKMKHPKEDVALSDGQAFMVGQEDYKAHLVVAMESHQRSTCHEHRTVNQANVDRANLDATGIGATACARHGSSSLILSSISRREKGSHMSLVMIHSHRRTLCRQMNMDYSLSNALLTLTGITLVLVMYDIMCQYGVHVRKHFRHSAYLRMPFELKVDQGIGLFHVHGHQDCCFQRFSPNFIVGTGMVDGEVIETLWAPTNEVSGSTCYAAAKHERLVESLRDKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6V7</accession>
    <name>A0A401G6V7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0107840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608815.1">
        <property type="nucleotide sequence ID" value="XM_027753014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6V7"/>
    <dbReference type="STRING" id="139825.A0A401G6V7"/>
    <dbReference type="GeneID" id="38774819"/>
    <dbReference type="InParanoid" id="A0A401G6V7"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="7">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="8">
        <location>
            <begin position="299"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="839" mass="93854" checksum="FA2519AD38D4B23D" modified="2019-05-08" version="1">MDGNSFAPLAFIHLPSPARLLRSAWCPDKDLLVIVTRLGGNDRISLWKMQGSKKWEVDVELDSSSRDEVTGIGWSPDGQTIAITHDPPKVTLHSIQDGRLERTLTISPPLTLLGRTYHLTDVWWFQERKQEATSSIPDIFKRGDIITGSAHSILRGQPLLDHLQDESQPLTATDLFAFQGSHSRMLAKSSIPEVILCWPTLPPDPLSASIKQSKLGGDQTRPGEELDEMDDSNVNSVLVASDDLGHLHCYLDGSYPLGAVVVGFDSSTTSLYKEKDIFFVHPRSSAAQATCLPPVVIQLPQLRQRILRDVARVSSSVRQLTWYVMRVVKDMREAWFGSDAQHGARELGPKWVRALEERQKDQFGVDEPHAMLDLTCLLTTGRASESLSDYLGSGEQMSERAIQKWESTMVDALIKLRDCSEKRVAPACQRLHLLLEEVHGWSQLSQYALFRIKTRDVAASLELTERAIVMASWLTATARRELTHFKEFMSWLKYETSRANSSTEAHTQPPPKHDMLEVNDYLMSGLVVSPIDKWFMGPVPRFSPQDIGVLGDQHDLTTVLQRARSVLKDREQIAWQSDARQKDLSHLDRNLDSLIQELATRCQRIFGEAANGAARSAVVLSGPTYPPLRVKNTWSSEDPRDLPLRDRTVQSSDQPDAFQQYLVMQTPRVGERSYLCLARLEHARVAAAAPLQVSVAVLESCVMQDDSKMPVDVLNAEFFDDKNFIVVYRPREVGQALIATVSYSDLSYETIQLQGYVNDLAREGLNMEVMQRLSDGQLSSVPMPIVQARTLAGCKEGKVTLAVNGRVGRRVACVLDEAGMSLEIFDMEGEEDETDELGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G734</accession>
    <name>A0A401G734_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0108640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608895.1">
        <property type="nucleotide sequence ID" value="XM_027753094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G734"/>
    <dbReference type="STRING" id="139825.A0A401G734"/>
    <dbReference type="GeneID" id="38774899"/>
    <dbReference type="InParanoid" id="A0A401G734"/>
    <dbReference type="OrthoDB" id="3256702at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46155">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46155:SF1">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR_LIPID-TRANSFER PROTEIN_SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="56459" checksum="5818769EB616E634" modified="2019-05-08" version="1">MAATLSFIKRQSISASPSAQSSIVASSSPGSSTAAASAASTPTAASTSGTAASSATAMSTPSRSDSPLPDPSSSSSAASSPPSSTPASTPSSTPSSTPSSTPSSTPSPTPSSTPSSTPSSTPSSTPSSTPSSTPSSTPSSTPLSTPSSTPSSTPSPTPSSTPPSSASPSATSSSINLQSLSASAPSLTPSSTLSSSSPPASNVQSASQASSTGPSSSSISAQSTFHSTVFVTTTNSDGQTVTSAPSFITETFTTTGSNGNTSYVTIVVGNPPPQSDNGGTDSTSEFFRNKGAVAGVFLIVGLAAASIVLFLVFFIHRRRRTRRMEHDHAVASTLAAVGYNRTPLDGDDDDAQPMAQRRSAALSAIGTISSSGGRAPSGYMDEPAGGGSAPETPMERDFDPYAAYGTIHPPPAAAGAPRKDGYMPARTSSPPPLGHQSTRSESMSSMGFGHAAKDSSSSHELLLGYSHGASASIGDPAVPLPTLDPSSGDTVVPPPRNPQRVSNGGRDNPTVETRAGLTPGVSAASSVYSNTDDVFDDAHAVRPALEVRNLADGENPGGEVSRGPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Q6</accession>
    <name>A0A401G7Q6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0110880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609118.1">
        <property type="nucleotide sequence ID" value="XM_027753317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Q6"/>
    <dbReference type="GeneID" id="38775122"/>
    <dbReference type="InParanoid" id="A0A401G7Q6"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19192" checksum="0C4C664B162206FB" modified="2019-05-08" version="1">MSANAILGHKWEATDFCKCICFGSNYTILNMQIPDNPAQPCLSCTKQWCLNQNLPICAGATLGVADPDTATGKEGDVEARCFQRDSPRDQLVVTLFLLTVFGLLLGAGIKSRMVKAGFDTNIPWNAGKRWWEAWAPQRLPEDMALGDRFRGLLGRGTRNRGEYIGISDFPSSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Q9</accession>
    <name>A0A401G7Q9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0110660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609096.1">
        <property type="nucleotide sequence ID" value="XM_027753295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Q9"/>
    <dbReference type="FunCoup" id="A0A401G7Q9">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7Q9"/>
    <dbReference type="GeneID" id="38775100"/>
    <dbReference type="InParanoid" id="A0A401G7Q9"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="9">
        <location>
            <begin position="68"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="10">
        <location>
            <begin position="600"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="805" mass="87221" checksum="0682E91B3B87089D" modified="2019-05-08" version="1">MSACSSLRRWTAANVLLIPKHSAARTLATHASIPEKNCSSITPPYTQLLDRLTLIREILGNRPLTLAEKILYSHIADPERILKDGDVKRGETYLQLHPERVAMQDASAQMALLQFMSAGMSRCAVPTSIHCDHLIQAVDGAEADLKRSIISNKEVFDFLESAARKYGIEFWKPGSGIIHQIVLENYAAPGMLMLGTDSHTPNAGGLGMLAIGVGGADAVDAMTSTPWELKAPQVVGIHLTGKLNGWATPKDLILHLAGKLTVRGGTGRILEYFGPGVFNQSCTGLATVANMGAEVGATTSTFPYTPNMRSYLVATGRAPVARAADEAAASGFLAADEGAEYDEVIEINLSELEPTINGPFTPDLATPLSQFGSFVEKQGWKDEISAGLIGSCTNSSYEDMTSVADLARQAKAAGLAVKVPFLCTPGSEQIRATIERDQVTDVLQDVGAVVLANACGPCIGQWKREDKKGEENAILTSFNRNFKSRNDGNRLTMNFLASPTIVTAMSFSGKLSFNPMTDAIELPSGKLFKFSPPTGQDLPSAGFAPGETSFYPSPTPEPQPETEVIIKKDSQRLERLEPFRSYFGASSGNHRGLELPSLRVLMRVRGKCTTDHISAAGPWLKYKGHLTNISENLLITAVNDEGGDVNVAFDHDHEPGQSETDTIPAVAKRLKARSQPWTLVVDDNYGEGSAREHAALQPRFYGCAMIVARSFARIHETNLKKQGILPLWFADKADYSRIGSGDVVETVGLADLLNHVPNASIKLRVLKRNGEVFEIPTRHTMSNDQLKWLKAGSALNHIRSQITQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Y7</accession>
    <name>A0A401G7Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0111640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609194.1">
        <property type="nucleotide sequence ID" value="XM_027753393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Y7"/>
    <dbReference type="STRING" id="139825.A0A401G7Y7"/>
    <dbReference type="GeneID" id="38775198"/>
    <dbReference type="InParanoid" id="A0A401G7Y7"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="309"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="122"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="641" mass="69528" checksum="2C69BEC1E55DA75E" modified="2019-05-08" version="1">MGYDNESSDDEEYVWVAAGKRRARGGPLRTCTITTNPSKSFRSGRSSSAPPSSSRRTRPSLAQGSLLQPSMLAAHTVDLPFDDDDWVAPPPTDRLYRAASVGNSWGVTSFGRGFDWKKKDEELQSPARHQGLQLSAEPQILSKDTPPFLRARPTRLSTVAVAKPKATTPPPAVPKSNRSPIFGSFISGPLTHSPMSSRPASPPITSSPQPMSPAELADSSIPTTLSRSPSSPRLSTPSRRRSSQQRVSLIAGRVSIVQVEPPSPPPNAPQKLVRTNSSRSFLSVASSTGPPTPSSEAVEQLSERSISEFVVEKEIGRGAYGLVKRAREMQDDGTLGPPLVIKQIIKSRILADCWKRHPKYGTIPIEIYVMSAISSTQYVLPPRRPWDPSRLLPEPDDSWVEGKVVSGHPNICPLLDFFEDNHYYYLVLPSTTPEPKDGEPPPPSDLFDLVESYPHGLPPSCIRSYLGQIADAMCFLHLKGIVHRDIKDENVVIGPAGRCVLIDFGSSGLVKKGGWDTFSGTLDYAGPEILRGERYSGPEQDVWAFGVVAYVMLVGECPFTTAAEAQEGLESPFANAAIALDERCGEGKEREGEEKDGGGALGDAAALVRACLQVDVSARPSFQTILQSRFLCGHEGWGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G898</accession>
    <name>A0A401G898_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0112810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609309.1">
        <property type="nucleotide sequence ID" value="XM_027753508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G898"/>
    <dbReference type="STRING" id="139825.A0A401G898"/>
    <dbReference type="GeneID" id="38775313"/>
    <dbReference type="InParanoid" id="A0A401G898"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="329" mass="36056" checksum="0F0043FC7C1D47D1" modified="2019-05-08" version="1">MSSSTSAMDTDDLPVVLPSTTTSGLSLALHPLPILNISEHLTRRKLQTKSNEPFVLGALLGTQNGREVEIVNTFELAVENDGITVDQGFFVARREQYKQVFPSLEFIGWYTVATRPTPQHIALHEQFTAYSSTPLLLILQPSTVFAASADLTAQPLPLKAYEPTVEIRNRTSRSVFVEAPFTVETGEAERIAVDWTAKGGEGGTSLESHLHAQRAAVKMLNDRIVLLVKYVADAIAGAAVTDHAALRALSALVASLPASASRGFREEFDTEYEDVQLTAYLATLTKSASILNDFVDKHIVLTASREERGPTGPRRRGVMGRQPDWDRFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9G4</accession>
    <name>A0A401G9G4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0116910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609711.1">
        <property type="nucleotide sequence ID" value="XM_027753910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9G4"/>
    <dbReference type="GeneID" id="38775715"/>
    <dbReference type="InParanoid" id="A0A401G9G4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="18272" checksum="A9890F39B19E90EA" modified="2019-05-08" version="1">MEKDGGGAVVLAAPREQESRPCVRVDIARWDALAGHSACIASSRGWGRRRRGELVGRGASPSTTRAGGVLLRTPRAWPADADGTAALAGSATALVRAWTTRAKGDGGVDESGTAVVPPRRPRAPVCSCWVRAACLPGRGRLHRQERDGGGGLLARTRTAVDRLQTAGFKWGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAS4</accession>
    <name>A0A401GAS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0204400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610156.1">
        <property type="nucleotide sequence ID" value="XM_027754355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAS4"/>
    <dbReference type="STRING" id="139825.A0A401GAS4"/>
    <dbReference type="GeneID" id="38776160"/>
    <dbReference type="InParanoid" id="A0A401GAS4"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="12315" checksum="0E16C8D0036DFFAE" modified="2019-05-08" version="1">MSHLSAYRVIVREVNRASISPRTTRNPVVASNFRAIFEQRPRGEQSADFEHDIQDVITFLTSQRMHKTLLDRYNPLHDLTPEQRIEATARRVGLNMPSPVKSDGDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAU8</accession>
    <name>A0A401GAU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0204770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610192.1">
        <property type="nucleotide sequence ID" value="XM_027754391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAU8"/>
    <dbReference type="STRING" id="139825.A0A401GAU8"/>
    <dbReference type="GeneID" id="38776196"/>
    <dbReference type="InParanoid" id="A0A401GAU8"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001494">
        <property type="entry name" value="Pachytene checkpoint component Pch2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="179"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="519" mass="57123" checksum="A70877D27651F431" modified="2019-05-08" version="1">MIEDIQDFTMAPPSPNPEKPLTIWPVHIEVRILPSATSRFDTIRNTVHTYLTSSLSHIYLPSTIQGWEDVPLLASSVSRIVASESPCPSASLPIEQTALQIHVYQPSDAAAFEELANGGPRSDGEEVMAATVCELPSLSWEGLWESLIYSDDIKSRLLDYIYATVVFSDADVDFNVVSWNRVVLLHGPPGTGKTSLCRALAQKLSIRLSHRYSNARLLEINSHSLFSRWFSESGKLVQRLFSSVMDMVEDEEMFVIVLIDEVESLTAARAGAMAGTEPSDALRVVNALLTQLDKLKHKKNVLVMSTSNLAKAIDSAFVDRADIVQYVDLPPREAIYEILRTCLSELIGKGIVADVEVPSLAQAQLYERTADFSDPSSMTPAFRLPNSQPTSHPSSQQSQPGSEHAHPQTNGHASARDSPERSKNVALRLFALAQKCRTQGMSGRSLRRLPVLAHARHIGTLPVPAPSRPAHANGEKARKRAGVATEYRGTATPVEVWLGAMERVVEDQVAERDHLERTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB51</accession>
    <name>A0A401GB51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0205770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610292.1">
        <property type="nucleotide sequence ID" value="XM_027754491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB51"/>
    <dbReference type="STRING" id="139825.A0A401GB51"/>
    <dbReference type="GeneID" id="38776296"/>
    <dbReference type="InParanoid" id="A0A401GB51"/>
    <dbReference type="OrthoDB" id="2757691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="447" mass="49413" checksum="3E8D9E33E57284D1" modified="2019-05-08" version="1">MPQSGPPAGVPGKDMSLFAGDGERSVGGSRGTRQPASEIAASSSEKRRRNAERASRREDGEDDVSDDESVDFPEGEENDPEAIETQLGGVPQPTTPEKSIDNHTLLSQILEMTPQSQKIALAMWQQGHKSQKSGKPTNACIEGPPLTVLSEKKIGLFSARMAQPHPQLAVLLVNGHHLPLSLCTTATIQDIYHNPEKLHFKKMYDLQGTKKEMVDVESWAKTEHKMQPEEWRDAWRHFMGILERVCDKPLQRRFAEHFTWLSEREDFTESFPTVLAFDIDIRRAYFMSSAPFEVGSTDYKEHFVQVQMRSLRELASQVAVAAAVPSRGRFDYRRSPPDAPPEAASASDKPFRGGRAPTSAGVLCLICGESGHRANACVRTTMHSGKPVFSTWSDNRLLVYSTRAELCLGWNVQGKSPCKGRFCPGTGGHRCSFCGSSGHTATSKRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB79</accession>
    <name>A0A401GB79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0206260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610341.1">
        <property type="nucleotide sequence ID" value="XM_027754540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB79"/>
    <dbReference type="GeneID" id="38776345"/>
    <dbReference type="InParanoid" id="A0A401GB79"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29985" checksum="9644E59F0FAAAD1F" modified="2019-05-08" version="1">MPPRLYPFILVAPSTRGLSLAITRHLLQTTTLPVFATHRTNTPDAVHMRIMDSLAGVDQTRLKVLPLDLTSEDSIVCASRALADALPKDSNPFIHAAFFSGGILHPERQPGDLVLENIQQTFEINVISHLLLIKHFSRFLPSPGTQTTHPHAQSAPTLSKWVHVSARVGSISDNRLGGWYSYRSSKAALNQVVRTFDLHLQARKIPALCVGVHPGTVKTDFSRQFWSNVRAEDLFEPEFAAQRLVDVVKGLRPEDRGKVWDWEGKEVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBD2</accession>
    <name>A0A401GBD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 14">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0206750</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 14"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610388.1">
        <property type="nucleotide sequence ID" value="XM_027754587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBD2"/>
    <dbReference type="FunCoup" id="A0A401GBD2">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBD2"/>
    <dbReference type="GeneID" id="38776392"/>
    <dbReference type="InParanoid" id="A0A401GBD2"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018812489" description="Protein disulfide-isomerase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="4"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="342"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="478"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE79475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="504" mass="56242" checksum="0A887D45F109D3E0" modified="2019-05-08" version="1">MRYSNILLSATALILLPWALAEGASDVIDLTPANFESVVNPEPLVLVEFFAPWCGHCKALAPHYEEAATALKSKGIKLAKVNCVDEADLCQANGIQGYPTLRVYRNGEYSDYPGPRKADGIISYMIKQSLPAVTDVTSENYEEFVRADRIVALAFLPSSTDVPGPEFSATANKLRDDYLFGLTIDKAVFEAAGVQAPTVVLYRAFDEPKVEYPYPVGSVKVKDFEQWIKDLSIPIIDEVGSENFQTYAQSGKPLAYLFVDPSDANHDEYVAALKPIAAKYNGAVNFVWIDAVKYGDHAKALNLNEPKWPSFVIQDLKKQLKYPYDQSLDFNAEAIEEMVSQFVDGKLVPQLKSQPIPASQDESVFTLVSKQFDEVVYDDDKDVFVEFYASWCGHCKRLKPTWDSLGDRYADVKDRITIAKMESTENDLPPSVPFRVTGFPTLKFKKAGSRDFVDYDGDRSLESLVAFVEENAENPLDAKVPFKNVTPPEGQVPLQQQPDHHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC72</accession>
    <name>A0A401GC72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0209610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610673.1">
        <property type="nucleotide sequence ID" value="XM_027754872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC72"/>
    <dbReference type="GeneID" id="38776677"/>
    <dbReference type="InParanoid" id="A0A401GC72"/>
    <dbReference type="OrthoDB" id="3173670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="153" mass="16808" checksum="43786DCF833DA2B3" modified="2019-05-08" version="1">MPPRAQPKTYILLLKTHKLTVFLTAPITATIESLKAEALTALQSSVIDAKLSNPDGMDVDEEPVPKVGGVKDFELSKSIRERGRPTGRYEVLNPEAIVQSVLVNWEPVFVQFKDENGQLLPVKVVMPSLFDEEDEAEIAAARKGKRKAAPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCD2</accession>
    <name>A0A401GCD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0210210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610733.1">
        <property type="nucleotide sequence ID" value="XM_027754932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCD2"/>
    <dbReference type="GeneID" id="38776737"/>
    <dbReference type="InParanoid" id="A0A401GCD2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="91" mass="10199" checksum="A30AC80E7AFF4840" modified="2019-05-08" version="1">MDHRRHQIAALGAAYIEHVSVSVSVCLFVFTMSTVLPMSTSREETTEEEQFGTTKRSPLYSGISKPVPFRLATGQTSKTPHLRLHSQLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD20</accession>
    <name>A0A401GD20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0212150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610926.1">
        <property type="nucleotide sequence ID" value="XM_027755125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD20"/>
    <dbReference type="GeneID" id="38776930"/>
    <dbReference type="InParanoid" id="A0A401GD20"/>
    <dbReference type="OrthoDB" id="2803029at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018999267" evidence="3">
        <location>
            <begin position="33"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="452" mass="50990" checksum="F8916D66D67E6E9F" modified="2019-05-08" version="1">MVVLAEMGRLIQLQLLVAAASILCIQDEFTSAKRISEDSRKKLQCRIKELEAEKEAMASRIGRLETENAELKRLLEEKEPDLRRAIDERDATQCKLASVRMTIRKLLSEKRERVNAEKLEYTTAEERALVELSGEQPWDEAGFTDQSGGGSPKSGPSSEDDDNPQATIPQAKQTDTTGLIGESLRDIIQETGTRPGNDKTAKEGQQAREQAPTGVRTASSVRKEQTTVASQEGWYLEYFKPPATAELSVGGWLYEQLAEHLQLDNKTTICNTRYVNVENLPTTKIEKAHSHHKWWQDACMHIHIHNDIAFLFNPIVLEGPSTTYLISWGTRKINRKVEKYISRDRAENPAFHLLVLPAEKEAWWYLGMHSFTIAQVLPVWSILNSQDKDELTLELKKRWDQAPGGQRIATMLEQGDLQQCTIELRSEGLADHSLAFLHDQLGMSITDCGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDE5</accession>
    <name>A0A401GDE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0214140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611117.1">
        <property type="nucleotide sequence ID" value="XM_027755316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDE5"/>
    <dbReference type="FunCoup" id="A0A401GDE5">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDE5"/>
    <dbReference type="GeneID" id="38777121"/>
    <dbReference type="InParanoid" id="A0A401GDE5"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="198" mass="22441" checksum="1E1986611F1E93EC" modified="2019-05-08" version="1">MSHGKQFTLFSHPLGPNGIKVAIVLEELGLTYEAVYLSAFEEGDRNVKGPLHTKYNPNGRIPTLIDHRSSDFVGILTYLVERYDAEHKISVTDLEDKITQLQWLFFQASGQGPYFGQAGWFTSWHPEKLPSAIERYRKEVLRVFGVLNSVLSKQEWLVGGKCTVADLSFIPFNVLAITDYVADYNGFDFARDFPAVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDL3</accession>
    <name>A0A401GDL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0214790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611175.1">
        <property type="nucleotide sequence ID" value="XM_027755374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDL3"/>
    <dbReference type="STRING" id="139825.A0A401GDL3"/>
    <dbReference type="GeneID" id="38777179"/>
    <dbReference type="InParanoid" id="A0A401GDL3"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="81" mass="8794" checksum="548B51124CB0546B" modified="2019-05-08" version="1">MVTYFRQNPVLRAKARFFIDVVSTKFVPTWTAFVSGKGTADAFVSATEQVTAVLPETGFALGECSTADIAVPCSRAHCFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDW5</accession>
    <name>A0A401GDW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611216.1">
        <property type="nucleotide sequence ID" value="XM_027755415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDW5"/>
    <dbReference type="GeneID" id="38777220"/>
    <dbReference type="InParanoid" id="A0A401GDW5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10270" checksum="CA239375D517AA14" modified="2019-05-08" version="1">MQMFGSMFVFGGRRAPPASLSLHRLPQCDDATPALHSHTLLAPWSPIFLRPPHSHGEPTRGQPGDTAWLRKVNDLALPSPFAPPSSSLLIHVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF58</accession>
    <name>A0A401GF58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611712.1">
        <property type="nucleotide sequence ID" value="XM_027755911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF58"/>
    <dbReference type="STRING" id="139825.A0A401GF58"/>
    <dbReference type="GeneID" id="38777716"/>
    <dbReference type="InParanoid" id="A0A401GF58"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="168" mass="18615" checksum="010CE2263FF4CC29" modified="2019-05-08" version="1">MGHTHSSIVDAQAQHPPRSIVRKQSKAAFSALTLGCANSPASFSPETYGSITAVTERYRSDEKASFDPPPLYASFTVDILEDSASGAYKLFLKQHPQYQLTWTLDALRRSDFARLDRTGETYVDYMGGSLYPESLLRAQTDFLHRNILGNTHSVSNSYVSLAASRIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF77</accession>
    <name>A0A401GF77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0305740</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611767.1">
        <property type="nucleotide sequence ID" value="XM_027755966.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GF77">
        <property type="interactions" value="457"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
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        <property type="term" value="P:chromatin remodeling"/>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
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    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
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    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="885"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1403"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="177"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="555"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="766"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
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            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE80854.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1670" mass="187178" checksum="49DADC7205A00BC5" modified="2019-05-08" version="1">MSFRNASTNSRAPKKSSRRRLGADGHGIPGIPGGTDAEDDRAARIQQRQHELEEVLDRHDTLVREAFHLEKFGSLVRYDPKVAKEDNSAVFQEYKTRFDLLEQSAEAGPSRRTTRRAHTERVQLLKGPVPGPSTASQGRQLRKAETLKQPDNISVWPALSAVKGKGKQNADIDGLVTTVHSERARRGNGKGKSSDQFAHSMPELRSQESSQTISGRRSLKRRADDIVSSAANGHPRPPLGKKRKVIPSISSSSAVDLYLPAETVDDLEQPDRITDNGKLFMPPSEPLPTVRSKRSFGRERHAQATKQILSSPNLPTAVISSHPPWPVKLALPRIKLIVRRPPPSLSSPRQRPSPPQYGESLTSLLSSYSMWDNKDIELDKLERMAQNDAAIWGRIDALRRHGRLLLPAEDVDFYFSSGSQPKPSGGAGTPNKPTGFGDIWARVIEAVVERYRSSPVIGPQVASQVASKIRGYWDGQAVKEDKVKLQEEKRLRALAKATIKLVVAEWKKAVHHVREEERHQLEAEEKKRGDQHLSALVDQSGSILKAQHLDLSKAVSRSRSSSVSGAFGHPASPEPQPSDSVSKTDEDESAQDESDDSEDDDGIGLSYLVQDAQDAPPIGKSVTSSRSPSPVPTIGQEEADMRSEGAASSQGALGTSRTASPSLSFGHIEDDASANMQVTESNTEDMSERSMSAMLSSYRRSPSPQPFPSVVPPFGMFEDISDIAFPGHHPDSALATMQLPSKSPAPSIVFTIQDESIKEALPVCQDAENPTSPDVESTPTHLDEASRSSTVQPEEGTELYNKNPRFSVQSDVAMETQVDAEDHDEHAAHEDNAAEDMEEDVSIPFYLRPFAVTPVEWDTQSKIKAPFLLRGTLRPYQQAGLEWLASLHTNNLNGILADEMGLGKTIQTIALLAHLACDRGIWGPHLIIVPTSVLLNWEMEFKKFLPGFKILSYHGNTKRRKELRQGWNNKYHFNVCVTSYTLASRDAHVFKRKHWYYMILDEAHMIKNFKSQRWNTLLMFRSFRRLLLTGTPLQNNLTELWALLQFLMAGTHFANLKEFGEWFSNPLERAIEMGNVNEETQQRVSKLHTVLRPYLLRRLKRDVEKELPSKFEHLVMCPLSKRQRFLYDEFMARADTRHDLQSGVYQKIANILMQLRKVVNHPDLFEVRPILTSFAMERSAIADFEIKALFVRRELLKSSDEDRVNLDVLGLQFVDNQNTSLLAAVETRRLDGTPHLPMITELPGEPPPYDTRTSAGYKRYRTYQLRAANIARWSHIGYLNLLRCQRMPIYSQELVRCVKPLHESLPPLAVTVTPYLNTVDRIHSAIKSYASRADEMAGIIDRFAFATPAVVARDLPAIALSGLEGPLLRTLQDMNFDVVLHRAAVKLQIAFPDPSLLQYDCGKLQELAQLLRERKAGGHRILIFTQMTRILDILETFLNLHGYLYLRLDGATKIEDRQYITERFNSDQRVFCFISSSRSGGVGINLTGADTVIFYDSDFNPQMDRQCEDRAHRIGQIRDVHIYRFVSRHTVEEALLRKANQKRSLDDLVIQKGEFDWRSLFSDEVALTKALGDVEDTEDAHAAAVAAREAFALEGADEADFEDGGTANRAIETAETEAETAETQQADDTVVLEDDEDAQAVEEEVEEEGGTVVEYMVAFVRADMEYFRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFD1</accession>
    <name>A0A401GFD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0306180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611810.1">
        <property type="nucleotide sequence ID" value="XM_027756009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFD1"/>
    <dbReference type="FunCoup" id="A0A401GFD1">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFD1"/>
    <dbReference type="GeneID" id="38777814"/>
    <dbReference type="InParanoid" id="A0A401GFD1"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="333" mass="35617" checksum="CF94B3F2538CDD97" modified="2019-05-08" version="1">MRVLLGLCSSRLPCHPTTRFLSRRCMSVRPEDNPAAAPRRKVTIEHLHKLRRAGTPITMLTAYDFPTARACDAHGVDITLVGDSLAQVCLGLPSTTRLTLPEMVHHTRAVARGTTAPLLVADMPFGTYHASPADAVRSAVRLVRDGRAEAVKLEGGSEVVPAVRALTAAGIPVMAHVGLLPQRHAMLSGYRVQGRDAPAALALLRAALALEDAGAFAVVLEAVPHPLAAYITRRLRRAPTIGIGAGAETDGQVLVWDDVMGTWGGHQAKFVRRFADVAGAVEGGVKSYLQAVRERTFPVAAESYEMAEGELEKFMRLVEEEALLSSGVGETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGX0</accession>
    <name>A0A401GGX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0311480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612332.1">
        <property type="nucleotide sequence ID" value="XM_027756531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGX0"/>
    <dbReference type="GeneID" id="38778336"/>
    <dbReference type="InParanoid" id="A0A401GGX0"/>
    <dbReference type="OrthoDB" id="2919059at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1074" mass="117631" checksum="1C62FC90A9A4D2E7" modified="2019-05-08" version="1">MFCPSPVLHDIADSSEWPPQAQEVALLLSQPLPEYISTGPWPFVSSIATHLLDELRQDTPYQGALMPSGQFVSRVHEVFDLVLSTVAALRELESLEDCGRPRPTVTLWSSLFKGIGMVCSPESCYLNGASFVLPRVSPRSSQVAFDGVATILISHVVDESGFSRSCSSSNAMDVDAPSDGTPSQSDGTDGSTSHNSMDLSIDGTRSTVDSEGDYADEDQESTDETSQELSGPSIDVPFDAHVLSGSGRRSFVVLPMICVADADNIRSLVTSVAYQRRIWDIDEPVVGFEISKFGTVARILLAWVGTEMDSDCLPAVHIACASTHSGATIGNFDLTDTRSALTLAQIVLGLDAHCQRIVSKLKHRPAIDAYHWRSDYVNEHEDQCDNGDLGTRVAHWARTIDARGEGGNNEVEIDLSTPPTSEMSKLPSIIESPGKPTTTESRGRSATRGPTSQTGSDSKTSRTGVEQDSVKSQSLKDDKASQKSEPKGRKSRSESATRTDRSSSRLARTTSVAFDGLVTPATWLFERKAFPIGLIKVPDGAEDADEINQKIDVYNKVVIEFAWPSRAWSTLVDIPILHQISTPCADLNQDKMPPVDKAVQKIQRVLFENYLTFAPNQKPAKLDPSHLAILSSRFSTILYASAGAYGRHVALSGLPVNEAEARYDWDKMLLQFCVPDSDRIVSPYVLFERELTFPRNKAVDSISDHDKSPELQRDLAQKQVDLALGYRHHCLTVLSSPRFDEAPALVQSQADAASSQALQFFLQLKSVSVKPDKMLDTLRNHATSEPLRGICDAIVVGHIKDAFDDKDSPATQRFLKKQALVQHTLTTQLKDKDKSSDELASQPPSQPSTGTPAARPKRTASRSRAQAADNIDWQKHVGDPFINSCSPLVLQDPTKSSDRPRDVDPEAITKDQLLLPVMVVEYKRWNEDQAKSLNQGRFYCVASVTFLAVLGIEGHPVFALVTNGVVGAVLLSWQSPQTKKIYVIERNVCTFDLSKPLQAFHFATFLIRLREQHEKLQALFEAKKTEFKAKVSAQQFEEWTMAAQDVLLRAQRAEAEAAAASRAAAEAAASPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH54</accession>
    <name>A0A401GH54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612412.1">
        <property type="nucleotide sequence ID" value="XM_027756611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH54"/>
    <dbReference type="STRING" id="139825.A0A401GH54"/>
    <dbReference type="GeneID" id="38778416"/>
    <dbReference type="InParanoid" id="A0A401GH54"/>
    <dbReference type="OrthoDB" id="3260303at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="52540" checksum="1B9DD0B28C78C99C" modified="2019-05-08" version="1">MARLIVLHTIWRRTPTSYSSSPRLDGSDIPHDIMHELREATASPTPLSEFLHDPILLSSLMGHRKKARRGSTQPRDRDRDRERDRDRERDHNKREKDSDTSSILTLVLAEEERQAHHLKALLRSTGDRLDYENRRADQAEGRARTAEALAREASARISTSDAARHQAELDAARTREEIKRYQMLAETAERELRRAESEAQRVERLRLEAEKLAAEARDVARKAQQALREHQAREEGREEGRRLGLRRRYSDGHEDGFEDGRTEGFEAGHAEGFEAGRAEGFATGRAEGYNAGRLTGFDEGKKAGQEEGYDEGFEEGRTLERKYAIEAFDRFMDSEVGRQSFMTAPSNERTQRWVEATRQFQEHYPRVPGVVLEPVEQTPPRPIVIHPPVASEPTPEQPAVSPEVIKQRSRESLRELPPPSVKEQPQAAVPPPLWLHRKLHHPQDGIGVPPVSTLTTSSIAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH65</accession>
    <name>A0A401GH65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0311900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612374.1">
        <property type="nucleotide sequence ID" value="XM_027756573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH65"/>
    <dbReference type="STRING" id="139825.A0A401GH65"/>
    <dbReference type="GeneID" id="38778378"/>
    <dbReference type="InParanoid" id="A0A401GH65"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="923"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="693"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="789"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="958"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1234" mass="133864" checksum="16A13BF7A1EF06E2" modified="2019-05-08" version="1">MLASTPTPEYTTFSTTKRDLSASPSYRAPPNRRTPQKFTSNSFSPMFTSPPRRHPPPTADPMDTDDIFQSPYSASSRPLSVRNDRIIYKKSRADDDEEFDNGWSFVPSSSTMFSHNMVPPSSPIPLRSSLRTPVKQIRATPDRPVLSVKHLNTPSVSPAVGSKRKPSKRTPVCTTPQCQGFLTPLNVTSAAGREQGDSSGVAFDRLAPLSAPRFVLHTPQTKAETEMHLKRQAETMTLLRISDMDRSGDESGYDSGPGEDNGRRLFGDNAAPNMVSSVASKGKTKVGLSRSPALRLLMRKGDTNDTEVVEAISPGGHVTKRRARSRPVSSELLESVRGAPVILDYKVNVASQYINEMQTNSVAFPPASRPHRSSSPSSSSSEIGSPLSRPRLSIMPLPHMDVQSPTSKPKGPLNRLASASSATLFFGPSIPARNTGTNADPSRKQSLATSASPSKGNASPSLPLDLNKRSSPHSRIRNRHSYAPHGSAREKRQSSSPCTSPPLKRHSDEDEDEDLFFSGPADTSFAFSLTEGTPSPKKKQKRDIPSPLQKKFRPRDSGVVLDESDSDSGLYGHGGAMPQASTSVSTMGSEAEEQELVTPGFAPGAASGWPGVTVMNLDDNMGVGSRTGMHGGRGVDAFIMRVLAAGATKSAQDIDGEPKRVPGTPVKKVKTAHLVQRPWQSAFTSKIGFPEFEDELQCGPGAKGRGKTKGRKSLPAAFPRLEKENRTAPAKHDRVGAEDDEDASPTTRKEKDSRYEGLGLGRPASGTLPPFARGIVDPKGKQHWLMRRSSSGAFSSGSETTTSGSATPTRLTPREWHLPPLRLPVPHSPLKNSLASASSSASTSSSAISTTRNSPTVAATAKRLPIRDLSERHAAQLTPARRPPTGLFAGVMRAAPATVKPVMRGRSSFPSSEEHPGRFEREFEEIDELGSGQFGRVMRVCCKYADESKASEIFAVKKSKPFEGIKHRLRLREEVDILKHLTQAAGGGHPNVLQYIDSWEEGDMLYICTELCALGNLAHFLWAYGRAFPRLDEARVWRILAELSAGLSFVHSSNVLHLDLKPANIFVTSSGRLKIGDFGLAVRYTGSSEMRGCEREGDKRYLASEVLQGRYGRAADVFSLGMTMLETATNIIVPDQGDAWHRLRHEDFVQVEAELGALSVTLQAVLKGMLRMEPARRVGSDMLARHPVVRRARSAMDGLRARQGDVFEASALGPVQDGFLSSIITGNDWDTMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH88</accession>
    <name>A0A401GH88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312390</name>
        <name evidence="3" type="ORF">SCP_0312570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612423.1">
        <property type="nucleotide sequence ID" value="XM_027756622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH88"/>
    <dbReference type="GeneID" id="38778427"/>
    <dbReference type="InParanoid" id="A0A401GH88"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15808" checksum="439BF74AB738440C" modified="2019-05-08" version="1">MYHGDYEVELEAKLLTSRGVLLFRKPEIAFRSEERGNIDTVERGPLPERPRTPLGHELEPTSHDTDSVWGYSVEFDGPDGSTSSVEPNGPNGWMLDAAVAPAFHTYRFKFMCTASQLRDKLMTTVKGASPVDGKVRCEYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHM8</accession>
    <name>A0A401GHM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0400400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612582.1">
        <property type="nucleotide sequence ID" value="XM_027756781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHM8"/>
    <dbReference type="GeneID" id="38778586"/>
    <dbReference type="InParanoid" id="A0A401GHM8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="11019" checksum="82D94109C760EA88" modified="2019-05-08" version="1">MHRAPSNVIPASKHCRTNNTSYSGGLYPRPSSPPCTLYAPTAEFRPSAARDATTPNPQSERERTVRTVHAVEPVGSGNRMVAFRAPQNPPHTSSKTFHSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHW9</accession>
    <name>A0A401GHW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612690.1">
        <property type="nucleotide sequence ID" value="XM_027756889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHW9"/>
    <dbReference type="FunCoup" id="A0A401GHW9">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHW9"/>
    <dbReference type="GeneID" id="38778694"/>
    <dbReference type="InParanoid" id="A0A401GHW9"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33865" checksum="898211ABEAEA4574" modified="2019-05-08" version="1">MADSNQCIPSLVQICQRVAAAHVDSICSLGDGWRYDLIEPVVENCSPDTLLRLEQASPYIEKDTEGIWKKLCFQRYPLAAEQYQSDCPGEPESWRDAFFVLKDMEAKRLEEVTSRLRTQRQEEADRKKETQIKITDKVPTAKRARGWGPTMPKSLLQKTRSEAARMQKGIYGMRMAPPMPTTKNYSVQPNTVTLAADTMHHPPSSSSSTSSASPQGSRVTVKAVTVRRRTASSSTKSIKRTAPPPPSVKSPQTPSSPADELVITPKPPISKKDRMASLFMPKHRAHSQLPSQTAPSRHDLRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI18</accession>
    <name>A0A401GI18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0402090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612749.1">
        <property type="nucleotide sequence ID" value="XM_027756948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI18"/>
    <dbReference type="GeneID" id="38778753"/>
    <dbReference type="InParanoid" id="A0A401GI18"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="254" mass="27964" checksum="A31BAF66C1612BDB" modified="2019-05-08" version="1">MHAERRRRHHLSVGVPSPHANVGASARCRSVPRVLLFIPTHLVLASCCELRSGRPGFGARSVGRPSSSSASGTFSVCPHRCALDRQGRERAIARRALAIVVVSARGFCKSVLPGWRRRRPRALRAPHRAARTRRARRRVGRPSSSSASGTSSLSSLIRHASMRHHALAIVVNRPGERQGLLQSPCFPGGDPACCAYHIAPPSRMDMQTALRRGREARAILARCIQHPDYQYPALAHLELRRYREIHCALQCSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIR4</accession>
    <name>A0A401GIR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0404400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612975.1">
        <property type="nucleotide sequence ID" value="XM_027757174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIR4"/>
    <dbReference type="GeneID" id="38778979"/>
    <dbReference type="InParanoid" id="A0A401GIR4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8088" checksum="D56C93B1E9D34DCA" modified="2019-05-08" version="1">MVNSSVPSASHGIYTGPITRLMAKRRQIEAQASGAGFQDQSGQSQLSPQHLRPRPTKINTTDSATQGPKSGRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIR8</accession>
    <name>A0A401GIR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0404260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612961.1">
        <property type="nucleotide sequence ID" value="XM_027757160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIR8"/>
    <dbReference type="FunCoup" id="A0A401GIR8">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIR8"/>
    <dbReference type="GeneID" id="38778965"/>
    <dbReference type="InParanoid" id="A0A401GIR8"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="366"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="665"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE82048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="899" mass="97312" checksum="AD55ACE22171BD8B" modified="2019-05-08" version="1">MQQARQSLRLTPRGVRASSSAVNVAPRSLGKWERPQPTSSVDSVPAGPSTPLPKGRSWARPEQPSSPLTPRTPALDKWERREDRRSRDPTPQVSSSSILERERAPPPHQAPGSSSFQRGPAPHQAGPGPSLPSREAAPHQSFNFSVLPRRQQQRQRPPRDTKWQKSGNGVPITSLGNILRKDRIQTDLAGVEKENTDETLEEEEGKTTPSINAGDVAEPLDADSDVAEYSRAGMHARHGWKENGSIVARANNPHLLRMRPGVHTPTYKENKRKGLKNAKPVNLDIFIPSVVTVGNLARLLNVRLDNLRRKMMKVGMEAEASYDHMLTAEYASLLAMEYGRNPVVNDEAAFDIYPPAAPADPSSLPYRPPVVTIMGHVDHGKTTLLDTLRSTSVAKAEAGGITQHIGAFSVPVPASSGEKGQAKTITFLDTPGHAAFSAMRARGARVTDIVVLVVAADDGIMPQTREVVELIKKDDTTVVVAINKVDKPGVDVSKVENALLAEGLQLETFGGDVPSVQVSGLTGQGLDQLVETISLLSEMKDLRAEREGNVHGYVIESKLQKGLGPVATVLISRGCLTSGAYIICGMSNAKVRLLTDSNGKNVKAAYPGTAVTVSGWKELPHAGDEVLQGTESEVKKALENRIRKTEMDATLGDMEALNEQRRLEREQKEKDENGDEDVNNAEAGPANSNDGPKELKLVIKGDVSGSVEAVAGALEGIGNKVARVKIVATGVGDVTESDVLRAKAVNGAVVAFSVNTPRSVQAEANSQQVPVFSSAIIYRLMDTVKERVIALLPPIIERRVTGEATVQQIFDIQMKGRQTKKVAGCRITNGLVEKNKLARVVRNGDTVHEGRLETMKQHKKDITEATKGTECGLAFEGWDDLREGDMIQMYQEIEKPGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIT6</accession>
    <name>A0A401GIT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen permease regulator 2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0404680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613002.1">
        <property type="nucleotide sequence ID" value="XM_027757201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIT6"/>
    <dbReference type="FunCoup" id="A0A401GIT6">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIT6"/>
    <dbReference type="GeneID" id="38779006"/>
    <dbReference type="InParanoid" id="A0A401GIT6"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="608" mass="68325" checksum="DB2ACA4CEA59CAE7" modified="2019-05-08" version="1">MSSAGGSFFPRIESVFYTVFDVHQGPKVVYQVPEGLILSGPISSSFANTALHTPTSASSTLSLPDSPSLQRLDSRQILSPRLRPVSANRCLFNFDDISKYVMPPSALCGRLVICATRKYRIIGFPMELRGNYERNYFRYNLCFVFDRNADLSCYEPVVRKVSRVLTTCEEESAFLSSPESSPAIHAILEQLYEDLNSYSETSIAIDMFNSIELKIFPFYPNPPVVKDWMVPLALINLTRRIEPNWDLTMVKVCQFIDGTNHVSRIARLAECDVGLTRQAISHLLYYQVVMMIDIFQYSNMYTLRKSIQWLVDESHVKEECGPYATRPGQVIADWPKLLHLYSRLKPGKTIREWMEDHDVQSLGIDVRRFTSFGVIKGFLRRVHRWPILLSAEADAQQGEKRVTSIGRKRSKSYAPMFQPRAPVALPEPTPRGIRGRLQDVFPTVAAVGAEAMAARWERAGIQPTRRASAAESSLEHLRDRDNPDSHKHPDQTPLFRMRAHSSSVHSLAPPLVSSASAVNASIDSLGGRDLGDGYTRPRRVSHSPSRPVVHQAGPPFPPNLIPLLDGEHHTDELCTLFEVGWPILKQWLILAGGGKGNGDLGRVSIIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIZ6</accession>
    <name>A0A401GIZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0405600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613093.1">
        <property type="nucleotide sequence ID" value="XM_027757292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIZ6"/>
    <dbReference type="GeneID" id="38779097"/>
    <dbReference type="InParanoid" id="A0A401GIZ6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="15850" checksum="F996E7DE4EF76C1A" modified="2019-05-08" version="1">MGTKTSDTSSDTPLMEYPHPLLARRQNQFPFDLALLVRTYPVDDLRYPNHLSRLHPLLRVAVIPTGMDVSLNKDHEPAGGHATDVEEIIMSATAPDDDEDHNISCGTRNVRRELMLQRSPLVARLFFFFSLFPLRYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJB7</accession>
    <name>A0A401GJB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0406420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613171.1">
        <property type="nucleotide sequence ID" value="XM_027757370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJB7"/>
    <dbReference type="GeneID" id="38779175"/>
    <dbReference type="InParanoid" id="A0A401GJB7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="320" mass="35322" checksum="8203B2E46D1E6BE1" modified="2019-05-08" version="1">MSILWYFGSEPVFLPARTPPCLIYTYLVCPLLINHRSYLAMSNAATTAQGTNMYEQPTHKAKSVWGYGPGALEGQTKLSRQDFRLMITVTRKTAAKHLDLTQRLPDQDKMRVEAVFPKVLEICPFVKSYKDLWPVKSYLRFYLAGRSESTVKARRRAECAKQQKLKVNSCISRRIFVGRTPFRSLAMRRPHIQASKGKSQPGGQNVAPQHPVPVSSSSGVALTSPPSASTTSPLPSVLPLFSAADPVLAFLKSLANPLPSLLQVFLAEGVNTIHGLRAAAMMTGRREWLNTLVVSRKITHFQAHLIYDGLTKLAASSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJT5</accession>
    <name>A0A401GJT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication factor C subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 41 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0407930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613322.1">
        <property type="nucleotide sequence ID" value="XM_027757521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJT5"/>
    <dbReference type="FunCoup" id="A0A401GJT5">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJT5"/>
    <dbReference type="GeneID" id="38779326"/>
    <dbReference type="InParanoid" id="A0A401GJT5"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="54"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE82409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="371" mass="41080" checksum="E2FBE4610CB78AF8" modified="2019-05-08" version="1">MSFFQPHAPKAAQKHKVDPENQPWIEKYRPKTIDDVSAQEHTVAVLRKTLTSTNLPHMLFYGPPGTGKTSTILALARQLFGPENFRSRVLELNASDERGISIVREKVKNFARQTPRAQVVASDGKTYPCPPYKIIILDEADSMTQDAQGALRRIMETYARITRFCLVCNYVTRIIEPLASRCSKFRFKPLDPSSTSNRLSHIATAEKVPVTDEVISALINTSNGDLRRSITYLQSASRLAMSSDPPTEITPSDIQEIAGVVPNHVIHDFAATLGVEVVSPDAMNVDDGAKAKRKGFDEVRKNVKGLIREGYSASQILSQLHDLVIEHPTLTAQQKARCALAFAEADKALCDGADEELWILEVGLRVFKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJU0</accession>
    <name>A0A401GJU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0408140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613343.1">
        <property type="nucleotide sequence ID" value="XM_027757542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJU0"/>
    <dbReference type="GeneID" id="38779347"/>
    <dbReference type="InParanoid" id="A0A401GJU0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="238" mass="26689" checksum="D656F2795AFE2525" modified="2019-05-08" version="1">MPSALLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELEQKWPPPFGESEIRIDQPTTLVDMHGRILAWILPRVLIPDRQTKMLQATRALHPAIAASKPFSTTASWRHNPLYFLPPEECAQFPAGSLCLSPGWFQQVREHMESGRLETSASLKLKGGRSWLRDIHDSSALLGAILAVVHPTLYAAGRQCLGLIQQDPELREMALNWSSPFNALQVIANWETPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK93</accession>
    <name>A0A401GK93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0409670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613496.1">
        <property type="nucleotide sequence ID" value="XM_027757695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK93"/>
    <dbReference type="FunCoup" id="A0A401GK93">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK93"/>
    <dbReference type="GeneID" id="38779500"/>
    <dbReference type="InParanoid" id="A0A401GK93"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="703" mass="76964" checksum="AF120264B8F11494" modified="2019-05-08" version="1">MSSLAFVNSPYHQDYPVPPSLAQSPPDQQDDTVSPLPPPYDSADILQGFENMRIGDPTVRGNSAPSFHPGEPLPRAGTSMSVRSAQSPPRLASHQPLPLPISPEQAAQRAGMRRSTDPALGFDGSSIHSGGSGSSAYNSAYSDAPEYAPYDRSVETDGTSLYSFDDPSHRALADGYIPREDTGAFPPGRSYTPANWQDQQSYAQPPGRTDFNSFYAAASDVLGMGPPPSAPPPVAQHAVASHSSAATYFQPPPNHSAQNHLYRSTTSPSLSPSSSVPYAGPYQQAFPSMYTGASQSSLSRGQPVASPPPNSEVEIEPRPSLQRSGTTTSVNLRTQKTKAVDLSAPPYTKEYIDQYRQRVRDDPDPEVHFLYAKYLIDAAKKIGADAKDQRGMKKYRDTLIVESLKVMRRLATQGQAYDEAQFFLANCHGTGMLGLQVDHERAYHLYLQAAKQNHAAACYRVAVCNEIGAGTRREPQRALAFYRKAASLGDTAAMYKLGVIQLRGSLGEQPSPREAVAWLKRAAEQADEENPHALHELALLHEASNSQIVPYDPAYARDLYTRAGHLGYTHSQYKLGQCYEFGVLTCPVDPRRSIAWYTKAAEKGHSEAELALSGWYLTGSEGVLKQSDSEAYLWARRAANKGLSKAEYAVGYYAETGIGIKQDIEFSKRWYMRAAGKFDRNLFGQVTALMDILFSQRKATKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLV8</accession>
    <name>A0A401GLV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0502400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614106.1">
        <property type="nucleotide sequence ID" value="XM_027758305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLV8"/>
    <dbReference type="FunCoup" id="A0A401GLV8">
        <property type="interactions" value="633"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLV8"/>
    <dbReference type="GeneID" id="38780110"/>
    <dbReference type="InParanoid" id="A0A401GLV8"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000048">
        <property type="entry name" value="CCR4-associated factor 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="261"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="329" mass="36484" checksum="80259D1E3A47F3EA" modified="2019-05-08" version="1">MNNIRDLIDKYCYVAMDTEFPGVVARPIGTFKTSSDYHYQTMRCNVDLLKIIQVGLTLADEEGNYPQDVSTWQFNFQFSANDDMYAPESIELLEKSGIDLQRHEEMGIEPNDFAELMITSGLVLVPETKWISFHSGYDFGYFVKLLTAESLPTTEEKFFDVLRTWFPTIYDVKFVMRACKVLKGGLQDVADDLGVMRIGPSHQAGSDSLLTMLIFFKMREIYFGDHIDDTEYNGKLYGLGQTFTTTNGMAEPVRGTAATIAEREDRGPPREHTQTPGPPQSHSVMGMAGPLPTSAMTGAMPAPLPPGTPYGPIGTNGPYIRTAIVGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLX4</accession>
    <name>A0A401GLX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial import receptor subunit tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0502440</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614110.1">
        <property type="nucleotide sequence ID" value="XM_027758309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLX4"/>
    <dbReference type="FunCoup" id="A0A401GLX4">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLX4"/>
    <dbReference type="GeneID" id="38780114"/>
    <dbReference type="InParanoid" id="A0A401GLX4"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE83197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="151" mass="16028" checksum="08D3E9FA59C10F5D" modified="2019-05-08" version="1">MVKVEIVEERDAQESNSPYASSSSSRTSSSVSLSSVGSEVDGEESFYERIVALADIVPPTTRHKISTRLSKVTGGLKTTTKVVGNLIWVVTTSALLVGLPLALVLEDEAKIIAQEKEMLAQQQGAQQMMAPSMYPPPGQGQAPKGVVPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN31</accession>
    <name>A0A401GN31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614550.1">
        <property type="nucleotide sequence ID" value="XM_027758749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN31"/>
    <dbReference type="GeneID" id="38780554"/>
    <dbReference type="InParanoid" id="A0A401GN31"/>
    <dbReference type="OrthoDB" id="2756970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="402" mass="45665" checksum="1DFD1EAB50DB3532" modified="2019-05-08" version="1">MAEPLDSQNSILIQSTSFFSKVRVMIRHAWALRDVESPLYTLYGHILTAFCETGGDTLEVDRALGCEPQSSFSTPTEKEFDRRIPDFTIMLTFLHDPAVFNRFSPLYRHPVLGFWVEIKTFTFPGKWMSDEGQQAARRAMWVNIQQLNEQATFAFTQFAGDKLYGMLILGIYFSVFEYLRPTRLPPPTHPLPPSVLHQPPSDSNQSWKRPKRKRGDDVKAQTNAKRGMERMVLNLEIDIPFQPSFFTPPPGDHHASEISLESARQDLDDFLDRQDEQVEDLRDAADFTASSEEDTSGNYYSSVRPSNAGANRRTRSQSRGDDALSEGDLDVPSFEDTDDAHDNAQSNIEDDIPLDFDFDLGRGVDDEGDENDDEAENDEDDEAENVSQYSHGTRTRGRESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNI6</accession>
    <name>A0A401GNI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0503520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614217.1">
        <property type="nucleotide sequence ID" value="XM_027758416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNI6"/>
    <dbReference type="GeneID" id="38780221"/>
    <dbReference type="InParanoid" id="A0A401GNI6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="126" mass="14704" checksum="61BF4A9662D9BB18" modified="2019-05-08" version="1">MDHYPRLPPYSSRSCFRYHPYPRARRRYDRLERVVGAEYGDDTEDTILDSPPPISLLPSNVFGATSNDDVSTLELDDRVYQHDESDAGRKQETLQVVKQWLAKVLVVWRKCQRLRAVQAWLPAKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNZ1</accession>
    <name>A0A401GNZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614835.1">
        <property type="nucleotide sequence ID" value="XM_027759034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNZ1"/>
    <dbReference type="GeneID" id="38780839"/>
    <dbReference type="InParanoid" id="A0A401GNZ1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="62" mass="6744" checksum="258B843FFD5FE774" modified="2019-05-08" version="1">MSGHERESVHEADHTLFISAWTLPPSPIIAQVWPKSGCFVHDIGTPQTPRRLAHLAGTSGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP20</accession>
    <name>A0A401GP20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase omega-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0510270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614881.1">
        <property type="nucleotide sequence ID" value="XM_027759080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP20"/>
    <dbReference type="FunCoup" id="A0A401GP20">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GP20"/>
    <dbReference type="GeneID" id="38780885"/>
    <dbReference type="InParanoid" id="A0A401GP20"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="205"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="160"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="355" mass="40721" checksum="9075AAE383F0ACA0" modified="2019-05-08" version="1">MRPSLFRFASHQLLHTTPRAPPARHPIYSAVQRRRMSSTRDVSHNTDISKMKHEENGSFKRKPSSFRSFIEMGGQFAPEKGRYHLYVSYACPWATRTLITRKLKGLEDFIGVSVVSPHMGADGWPFAKADAFPGADDDPLYASDHVKDLYLRVQPNYEGRFTVPVLWDKKTETIVNNESSEIIRMFNSAFNELLPKNKAAIDIYPEPLRKEIDSVNEWVYDTVNNGVYKSGFASTQAAYEGAVVPLFASLDRLEKMLKGKDYLIGDQLTEADIRLFVTIVRFDPVYVGHFKCNLRTIRDGYPAIHLWLRKLYWKNSAFSSTCNFDHIKTHYYWSHTFINPHKVVPVGPIPNILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPC0</accession>
    <name>A0A401GPC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">O-methylsterigmatocystin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0600190</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614955.1">
        <property type="nucleotide sequence ID" value="XM_027759154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPC0"/>
    <dbReference type="STRING" id="139825.A0A401GPC0"/>
    <dbReference type="GeneID" id="38780959"/>
    <dbReference type="InParanoid" id="A0A401GPC0"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE84042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="517" mass="57751" checksum="D3712F4968B6EC31" modified="2019-05-08" version="1">MWAVAVIACAALLSRNKRNPALPPCPPADPLIGHLRQFTFAPQRELFQKWATAYGDVFHLNILGQIIVVVNSLQVATDLLEKRSANYSDRPACTALEMMGWKANVAFMRYGARWRKHRKLFQEYFGQSQSLTYRAHQTEEARMLLKDLLTSPAEFKACTQKYALLSIIGIAYGHQVKLDDDVYVKIAQGAIHGLEEAAAGTTLLDLLPFLKYIPYWLPGCASFTAAVRQWGPATKSLCEYPLNDVRKKMEAGTAQNSFFVSHLERLGTDGVDEEDLEDIQGAAATILDFLISGKTSSLIQSFLLFMLLFPDVQRKAQEEIDQVVGSGRLPDFDDRDTLPFVECVLQETIRWYPIAPFSREPPIDRHSDVADLRPLAIPHRSLDDDIYNGMLIPKGSVIIPNVMAMSRDETMYKDADKFLPERFLPAPAGRGEPHLGVIFGFGRRICPGQYFADNSAWIVIASILAAFDICKPVGADGIAVEPHMEYTTDGIASRPMPFECVLRPRSETAKALVEQHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPP3</accession>
    <name>A0A401GPP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0601640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615099.1">
        <property type="nucleotide sequence ID" value="XM_027759298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPP3"/>
    <dbReference type="FunCoup" id="A0A401GPP3">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GPP3"/>
    <dbReference type="GeneID" id="38781103"/>
    <dbReference type="InParanoid" id="A0A401GPP3"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="99"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="12">
        <location>
            <begin position="486"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE84186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="554" mass="61636" checksum="F288EF33771A32DA" modified="2019-05-08" version="1">MQYVKARSVVGRSLVRPRQPATTSHTHTLRLQLARRLASTEATPLTPPSPRRFSIIKRFLQTLGGFTLLSAGTVATFYYFAQKDRTPGHQLPHDPEKKTLVILGSGWGATSLLNSLDTSEYNVVLISPRNYFLFTPLLPSVAVGTLNPRSIIQPTRYVTRHKARQVAVIEAHATSVDPVAKTVTFEDTSEIQGLVSLTTINYDYLVFAVGAEVQTFNIPGVKEYACFMKELEDAEKMQRRFLDCLESAAFPGQSQDEVDRLLHMVVVGGGPTGIELSGEIHDFLEEDLRSWFPELANSVRISLVEALPSVLPMFSKRLIEYTEAQFKQAKIDILTKTMVKEIKEKSVVLQMPDKSIVEVPCGMVVWAAGNTGRQVTRDLMSKLPEHQTNKRGIVVDDHLRMLGTDRTIFALGDCTATSYAPTAQVASQEGAYLARILAQIAKADNLESRLHALRSSPETPESKAEITSIGRQLNRTRKLRPFEYSHQGSLAYIGSDKAIADLPFFNGNLATGGVATFLFWRSAYLSTLFSLRNRTLVATDWIKVKLFGRDVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPV9</accession>
    <name>A0A401GPV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentachlorophenol 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0601670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615102.1">
        <property type="nucleotide sequence ID" value="XM_027759301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPV9"/>
    <dbReference type="STRING" id="139825.A0A401GPV9"/>
    <dbReference type="GeneID" id="38781106"/>
    <dbReference type="InParanoid" id="A0A401GPV9"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="557" mass="59597" checksum="9C5D8C2232BF5259" modified="2019-05-08" version="1">MSIVPVNGVLVAGAGPTGLIMAISLLKNSVPVRIIDKRSHFHGGARGTAIQPRSLELLAFLGIVDGVFDIATPALLLAIHGPDGRVSKTTKWHEDAEPSPSIPYPELASTSQAEFEKVLRKHLESLGGKVELGVEFVGIQQTADKVTARLQISRNGEIAEDQYDCKYVVAADGAKGRIRSQLGLTFIGETKESERMFVANVHASGVDRDHWHMWGNMSIASIGLKPLNPAPLFQVQALGRDLPAVLPKDTEGIQKLFNSISGVTDIKLEDAEWISEWRANIRMVNTFSVGRVFLAGDCAHCHSPAGGQGSNTAMQDSFNLAWKLALVYKRLASPALLATYSLERMPIAAELLDLTTALHAEVWDRHASALDATTPRTIQNAMFRPKRLLQLGINCRWSPIVLEERAGAGAGSEPASAYGQDSAYVRAGDRAPDATLLEDASAPGAPTSLFALLSVDRHTILVFAGTSTTSADLQSTVITLRVHEHSGVARVVAILPCVSSGFQSDGPMLVDTAGYARNAYGVQGEANTLVAIRPDGIIGAYALTVDGVSRYFTNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPY8</accession>
    <name>A0A401GPY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0602610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615196.1">
        <property type="nucleotide sequence ID" value="XM_027759395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPY8"/>
    <dbReference type="GeneID" id="38781200"/>
    <dbReference type="InParanoid" id="A0A401GPY8"/>
    <dbReference type="OrthoDB" id="3135897at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="124" mass="13545" checksum="F162CBD627BC3CAC" modified="2019-05-08" version="1">MQLNDDAGTFVSVPSLLASPSAVSASSVPVVRFDNGKRSYSGVLAFSTSDHVVQGIKHIAEQLMDKGYQIKFTYKENSTDANLELTLARTGLAVTRPRRKCPPRSTRSSTRASARTSRRTASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQD7</accession>
    <name>A0A401GQD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0604160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615350.1">
        <property type="nucleotide sequence ID" value="XM_027759549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQD7"/>
    <dbReference type="STRING" id="139825.A0A401GQD7"/>
    <dbReference type="GeneID" id="38781354"/>
    <dbReference type="InParanoid" id="A0A401GQD7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="390" mass="42295" checksum="2741257F0716E9C8" modified="2019-05-08" version="1">MLIEQVNELKRKRHNARALSRTVDARYLFEDRDHPNKEFMTIATDDVPDATSILKSHQVAGDDGFRLSPIPPDLPLPSLPSGIFPALTEESDDDDGASKALLQRSGNPHSRRSIPVIPIASNIHRMHSNSSLLSSHDMDPVSRSLPRALMDVHMVNFSSSPNVQGYPYTSRERFGDMISSSLGAHEGGLGLRIAGMGRPSDGPEPDDQDKQRERLRAELRRVLEDPPPTTIVRRNTVSEPEHVRRTSATASSVFTRNPSPDSTSPPSSCASAVAVPSSSGAPLPVSTAQHQPVSRASTAAMAAERARASAASSTSTSPTSAMASRERDVTQPQPQSYSQTRPSNPRRVSTDGTKAKTLTTTTATASNLTRTIWAMQEAQRITQQEVQRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR53</accession>
    <name>A0A401GR53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0606280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615562.1">
        <property type="nucleotide sequence ID" value="XM_027759761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR53"/>
    <dbReference type="STRING" id="139825.A0A401GR53"/>
    <dbReference type="GeneID" id="38781566"/>
    <dbReference type="InParanoid" id="A0A401GR53"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1079" mass="120152" checksum="FAE956BDFC8ED2F0" modified="2019-05-08" version="1">MDLVWNIFYHFKIDDDSLALLMSQCEKLVDMSTDLEAWLTSSYSRFLRVCDRRTLSQLNRQWKVYVTAKDFSRSKNSTLWSTYSRLYNDRFGTDETPTLNFSVARSVGPFWADAVFILGKHFQHFWKTGTLYTEPTVIASASNINPTFIYSMAGEGCGVHYGTYPLQCFHLAPVFCASRTEAVEVSDFISCAKLQFQCWCDSFREAVSPNSRDVVTIRFFAGDALALCHTLSHCHLTSSISASLHVSAWAGDELVLDGGDYDTKSAFAAPTTFNVVDTSNIIDHVGLLNVLIAVVPVLAYGPSSTLYTEGLQVKPGKDAATMFVDRLCADIPAIALIFGLTPTAYVSRFNTHSNAHELMFSHAVANPHYHERVAWRIPNLCDSAALSKDVVHPSFEHSALARLLYDIYYRMFQHEDIVRNLQNLTITNSDIHYHRSTFAALLGLVKSRVYTDWDAVMVHIFDMLHTDHRLILGSNNYQELCCQLHIRGIYSVDTMRPMQTVVDIDRSSGIFKGWSSVPPVVCLVLVVPRSKLQIFEKRTREKVGSPILQVEVRGQAYHNVFSAIQVTLGSVSLQGSGSNARAVLTEDIAGWSGLSPLVVSVWMPAYNLACEQSSPKISLGIHSTPATTMAFKDELGLRMTLFTTELTDSNFVHIVSERPNRPRELACLRASVESPVKPIQRVDVALDEISVATLSAKWDVAHLPNLDTRAEVKHEQVSSCSLKLRWDNAENSLVYPFPIDGSQAKLRVARKSGWVEAIVPVSRPLKGSFCTKNFSPIITPNGPPILWNIHRVNLDHLPVIDVAQVQLSSRLNSHFAMAFSDREASLRQQFASLSTPPPDLLLQVKDTIQCLLSRTMKKNARHMFALADPARGGIYTIIFVNDVRLDLPSHTVVADVCILPLTTGRVNNLGQIMHSLAANGKMIKINTTGDEVSAWKHLLPAFVERCRTWSHKPTCEYLRAGTIPLTVEFDKNPICGCGEGISLGALSKVSQWKRLAPYMTRAAFSQFFAVSFIESVGSALKSIRQILKADTDVAKVCSQCGKSGELFDCSRCKKVRYCGESCQKAAWKQHKLVCKARAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRG0</accession>
    <name>A0A401GRG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615725.1">
        <property type="nucleotide sequence ID" value="XM_027759924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRG0"/>
    <dbReference type="STRING" id="139825.A0A401GRG0"/>
    <dbReference type="GeneID" id="38781729"/>
    <dbReference type="InParanoid" id="A0A401GRG0"/>
    <dbReference type="OrthoDB" id="2563900at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="382" mass="39811" checksum="A4D77F93A3C478D6" modified="2019-05-08" version="1">MASATAEHPPPMATLSPAELRHITSSNNLASPARERRLSNRNSQYLRTHRMGSRSPNSIPSSPTSVHSSSSAIFERDIEPISASPTSFAHSSDPHRIPRGKISEQLDQSVPTVLDSAAAILAATSSADDDFDCISIVAPAPQDNGYQSGFTSPISRLSSRSPSPTGVNRRSLLFSTSPPIQGSPPVRPVVHTAPPPPPPSTVTQTPTSAYFSAASSATPSDMDSAESSPTTATHHEHPLHGLPPPPAPAPVPAPATITIPSLPASHPPSPKNSSKRLSFLSYMDLLSSIPASTLPLSSFTSSAVASEPPPHIPSVIGLPQAQAQYAASSSAGSIHASSTFERDAASGMVDDVGGEWEREGLGRGLEERLEALKPPHPLPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRI0</accession>
    <name>A0A401GRI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615738.1">
        <property type="nucleotide sequence ID" value="XM_027759937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRI0"/>
    <dbReference type="STRING" id="139825.A0A401GRI0"/>
    <dbReference type="GeneID" id="38781742"/>
    <dbReference type="InParanoid" id="A0A401GRI0"/>
    <dbReference type="OrthoDB" id="2989516at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="429" mass="47885" checksum="1F86642FED50833C" modified="2019-05-08" version="1">MYLTDGVSESGTYESPSKYSSNQWSVRRPPAPPTSIPLDDGFDAVTTEVPTEWNIGAVRHRDYEESVSGYRNYVMDMERKLSGEDDYYVSSGKTFDNTKRSDLTYTGSMRTLKRSPLNMPIPENARKISGNRGKIELVEQKVIEDNPQRTISLWRERVAQSSGGSNSRYDDADDLRSDHTNSHAHRRVLSDDSRMRRVASHGRTGSGGTNAHPRGTGREMEVRRSGRASYERSEYMVTYAQPSRNGFPMAFYAQSEIGNAIPLKNQGSQSNSSNAMVNKPLPDRSISSGNRRLSGRHSNERNEYMITYAQTSPFGSGSTTRTPSLRGQRTITMTPLQKKSFIPAHPTDASTVTKATSTSSVELILSSCDPSLLHIAPILSDLGIQRLEHLRAIARLSEETRDKEIKEQALKRGVTVVEWAILLDKLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRT8</accession>
    <name>A0A401GRT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0700590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615792.1">
        <property type="nucleotide sequence ID" value="XM_027759991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRT8"/>
    <dbReference type="GeneID" id="38781796"/>
    <dbReference type="InParanoid" id="A0A401GRT8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="70" mass="8098" checksum="633DCC405AAE711D" modified="2019-05-08" version="1">MYNVNVTVDSADQDFNSLLHLLARGSMWHVHTHRLRDIVGCTSPAPPILRTSSEQDPAEHEHDMRYINDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRV7</accession>
    <name>A0A401GRV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0700790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615812.1">
        <property type="nucleotide sequence ID" value="XM_027760011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRV7"/>
    <dbReference type="FunCoup" id="A0A401GRV7">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRV7"/>
    <dbReference type="GeneID" id="38781816"/>
    <dbReference type="InParanoid" id="A0A401GRV7"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE84899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="10292" checksum="CE2E3CEFB7671A87" modified="2019-05-08" version="1">MDFSQMNAAEQAHMSKVIEKKQMQDFLRMYSNLVERCFNSCCNDFTSKALSSKEEQCVNNCTDKFLKHSERVGARFAEHNAEAMGSAPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS22</accession>
    <name>A0A401GS22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0702180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615945.1">
        <property type="nucleotide sequence ID" value="XM_027760144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS22"/>
    <dbReference type="STRING" id="139825.A0A401GS22"/>
    <dbReference type="GeneID" id="38781949"/>
    <dbReference type="InParanoid" id="A0A401GS22"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="4">
        <location>
            <begin position="278"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="473"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="721" mass="81145" checksum="1260D37454A0F661" modified="2019-05-08" version="1">MASVEKSTISGPRPLRSRTLPLRLCGQATWDVNSNLTAVTHGFSRVRCSLVYRNFDNLSEAAASLSKAITRTLDFSGHGRSSVAATSGFHSAHNGLVFACELLQSHLSTLHQDLDGEALDIALSRASQLLDATMLNYRGFLRAVEMNNLQVFSSNDVQAIVHRESVEQNAAASVPKSRRKSVLSRLRTFSLSCMLSELVSPLDVLNGRSTASAITLVEPSPMSIKSRQTSFRAKCGDTKNASYNSDITLDLEYIRQMLLSNASSDLHPEETMDVVRNADGSISLATFSELIHMATDQREFLKGYLADLVDVLFLYFRSFATPEKFFEMLLERYHGKAASALGQEDLPRWNQDHNFSKVQVTSLIYMWLKFYWKPTTDECVRQRIIEFSHDSIASDTDIPLQLVKLVTSTICECSPGRTGHEGGRWLEKEITRTETAAGTFPPTDFQARLQYLETFGTDDTSLVNARYFLGTGGAEEIARHLTILESELFHTFVPEDLINFADRGLQSKLVAWRKFSDALSLWVRDCILEHSGAADRARLLEMFVTIAQDCKTMRNFSSAQIIVVALRSSCISRLQQTAKAVSQRCRDVYQELEEFFDSSKNWSPCRTELVQNLPAVPLAMIFVKDIIHCRDGLPRIMSTVGTSSKPSQEYIPLNYYRQMTKIVRGLEKCYGSYKLQRSEFLYGWLKHNIARLQQDSYSTHEGRLVQKSLLLEPKSLTPSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSA3</accession>
    <name>A0A401GSA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0702350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615962.1">
        <property type="nucleotide sequence ID" value="XM_027760161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSA3"/>
    <dbReference type="GeneID" id="38781966"/>
    <dbReference type="InParanoid" id="A0A401GSA3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="257" mass="29493" checksum="610496D7984762D4" modified="2019-05-08" version="1">MNEPSRARREGHRDRWTCGVDGVCERKGPLRVVKVCTLARTFVGRPRGHEKIYISSTLLHAHPSRERRHVDCVLSPSLFGRTIDSASRDAPVNEKTAAFRRVAKCGGGMRVQALRYLPQRRANPPRSQDTRRREDHERDILDITRAPSRNSRRRRKIYADLLIPSVRALRRITERATQCRPLNRQNGDGDYSPDLYYQQHPASHPAARQSLPARRRLTHDAECCEVHVGSTTPTHRKQNVSTAPRQRTRRGTSPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSD5</accession>
    <name>A0A401GSD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0702650</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615992.1">
        <property type="nucleotide sequence ID" value="XM_027760191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSD5"/>
    <dbReference type="STRING" id="139825.A0A401GSD5"/>
    <dbReference type="GeneID" id="38781996"/>
    <dbReference type="InParanoid" id="A0A401GSD5"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="575"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="370"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="540"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE85079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="651" mass="67839" checksum="32C47767F7947916" modified="2019-05-08" version="1">MSTLHPPSPSPSPGPVGNANGRSPSFRASMGPSSVRPSVATQGLPASPRPGGVSGAGRPTSELLGSAGMFQTPEAEAIDQWFETFQNYEVTLEEMAAASLDVNFKEELSAIEQWFKVLSEAERTAALYSLLQHSTQVQIRFFITVLQQMARADPITALLSPAMGSSMQSQMEAKLASMNLKSPALKSGLPASPTARNFSANRPSLGMEAGVNGFLSPDSAHDPATTLAQQRAKLKASNASHRISAPVLSTTMGADSRTWGSVSNSLAQVDERASSPAQEISIPVSNGNVASRPKSTDFSGAANAFKSPRVGGEPDGLSPMVGDSWASMVNTPLMPMFKDTRNANQSLDAAAAKLNDWTATGGGVPLIADPPKKFNRLSKGSTGLNNDAQNNGVYGEDGNPVGPGGAQQHSQRNGLRNASGAGNLNAFGGAGGWNGTRSPALSNNSNRFVDETNLNGLGIPGFGMGMGSPGLGIPGAGGLNMAAFAAAGMPLSPFGNMFNMSNLAAMGLTPEQMLAMQMAAAGQLGQPGLGAFGMGMHAQNSPGSRSGRGMGNMRSPGKSPSVRDSKKDEEEVDPKLLEDVPAWLRSLRLHKYTPNFEGMTWKEMAMMDEAALEEKGVAALGARRKMLKTFEVVRKKMGLEAPASATLTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTI8</accession>
    <name>A0A401GTI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydantoinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0800100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616406.1">
        <property type="nucleotide sequence ID" value="XM_027760605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTI8"/>
    <dbReference type="STRING" id="139825.A0A401GTI8"/>
    <dbReference type="GeneID" id="38782410"/>
    <dbReference type="InParanoid" id="A0A401GTI8"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="207"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="4">
        <location>
            <begin position="602"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="5">
        <location>
            <begin position="768"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="997" mass="105807" checksum="8F1E43D20A16E95E" modified="2019-05-08" version="1">MTLTSPVLRLGVDVGGTNTDAVLLDLSPGPRRGSVLASAKHPTTPEVTLGIRNAIQSVLKQAKDVSHIQALSIGTTHFVNALVERDPRRLDKVAVIRLCGPFSRGTPPFIGFPRELRDLLEGPHFLLSGGLQIDGSEISSVNRKEVEEACAEIRKQGISVVAVVSVFAPIDFEIKQEEHVASIIRELLKDVNVVCSKEVAHIGILERENASILNASLLRYAKKTVTGFRSAAKALQLQCPVFITSNDGTLLSCEQAAQLPIRTFSSGPTNSMRGAAFLASLESGHAKGESALVVDIGGTTTDVGMLLPSGFPRQAAAHHEFCGVRLNFSMPHVTSIGLGGGSIVQQNPATQKVTIGPDSVGYRILSEALVFGGSILTATDIVVASGHAQVGEASLVGHVDAAVVAAAEARIRTMLQNVVDAMKTSAQDVPVYLVGGGSILSPDALEGVSKVHRFPHFDVANAVGAAIAQISGIVDSVEDTSASTVPQVRAIVEQRAIARAIAAGADPKRVAIIESEAIPIAYTPGRCRFYVKAAGEWSGSSSATPDDSGLEPVDTAETVPTANGDAKARTHAVEAPELVTADDVLAYKPKVQRGEWFLSEVDLEWISEGCYVLGCGGGGSPFHTFLHLREMVRSGEVIRVIDLSALEPDALVGWGGGMGSPEVSAERLLGEEYNEATDELLSFLGMKKLAAFCALEIGGGNGMINMIPASTKHYNIPCIDGDFMGRAYPTGWQTTPNVYDPSGKGLNLLPAAISSGDGNVMIMMKAKKDTEIDRALRAACVEMGTLVGQAHRPLTAEFLETSLIVNTVSLSWRLGRALALARRQHSIARIGSILVDALGGRKSGRVLFSGKITDVQRTVYKGHTIGSVHIDAFAVDDDLEEDPEYPTERFSGSLVIPFKNENLYAEYHPGDGAPSKIIATVPDLICVLDAQSGAALGTPEFKYGLRVLVLGITAAPQWTDTPRGLELGDLRAFGYDDIPYIPLGTYSKPRSVIEEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTT1</accession>
    <name>A0A401GTT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616548.1">
        <property type="nucleotide sequence ID" value="XM_027760747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTT1"/>
    <dbReference type="GeneID" id="38782552"/>
    <dbReference type="InParanoid" id="A0A401GTT1"/>
    <dbReference type="OrthoDB" id="2781857at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="939"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1160"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1190" mass="129183" checksum="E5FC0E742D7394C8" modified="2019-05-08" version="1">MATEGNIQILVQTELQEDYTVQAPLGISGEPTSGLALNTDRNGRLNVFYITNNKIMNATQVLEPDGNTAQTWTVEDTGFPTTVVPQYVRAILLPSGYDFVVALGNDHNVYTLSTTARYPVWSAVKKSNSSWKPSTLSPLITNDGTLLIAALMSDGKVFKINPVKGTWSQDASVKIASSSVIELEVSGLFGGLRDDSTFGYLLSGKVLDESNSFSSGLAIVTSCGKLPTVRNIASGTFNSLAHVSIDKTTSTPLIFAIDQYHRATYFKADGRGGYASIYPLGETVKVTQLDAVLRKGVNVENQSMVWIEVLAMDTSGNLWHVESAPSADTPPSPSMVISSITQATNGDFIVTKWRSPAIISSAAITGFALSDSGQGFSYLVATSTSSQSTVLTSIVQDPTTSDWTTTRLAESSMQVGDVVRRSVYYIEVTCRDENQIQMPGLSAIVSAIEYADVDINGVTTTLDGLRSHSTLTNPQGKICITTPVDNELGCPTFTIWVEGMNAEHHVDVQPSGNIQAQLASITSDELKNAQDQTDGSYLFADLTDTQRSDLATSLNKTMQVFSNTPLVVPSTSLSRRYMHGKTNAAVARTRMKRDRSLARIHHNRSHVALHVSFRSGFSVNVVSHEEAAKLAATIRASGLPSLDLSWGDLWESVKNGFSTISSTIVDPVGNAVDATVTFWKDTVEYLWTGAATFVKQGFDLVSALFGKFKCGFNKLLNWLGYIFNWDDIKQTAAAFRQKFVALIENGKDCVNNQLPSLIDPFFLKAKAYLQDNYDSVVTETSTTTLDPKASGTSTDAIDDLPSSATWLFNKVINAPNGGSGGSLSPSFLGLESLFEVWQTFLKKMLDTGISDDFKKALESVVEFFKTLNSRDIIEGQTIAALLKVCKNALVLLIDYAQGLVDTALTVVSQVLDIILRVFDTPIEMPILSAIFHALGWEDFTLWTIVCTPIAIPFTIAYKVLTGAAPFQTQNEDGLYILHAKAKSRSLGDYVTLSQGIIAALYIFVDGSLDLINLIRSREAPGAVAFEYPAERMLNGYAVGIPLLQFSLSLYPLLDPAPDDPAYRRTVVGWVMALFFNAYNSFITCGSNLRCTARVVPPFYQPVGLTLLGGFAGWASPFMHLVNMIAGSEPNNTSTRASLAGEWLLPLSCWGKSLIMIQDPYLIAAATQLILDYVAGYGAFASWVYSFQQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUQ5</accession>
    <name>A0A401GUQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0706510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616377.1">
        <property type="nucleotide sequence ID" value="XM_027760576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUQ5"/>
    <dbReference type="STRING" id="139825.A0A401GUQ5"/>
    <dbReference type="GeneID" id="38782381"/>
    <dbReference type="InParanoid" id="A0A401GUQ5"/>
    <dbReference type="OrthoDB" id="549336at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55440" checksum="55627AA117F46D2D" modified="2019-05-08" version="1">MPSHYTQRRAAPFLVAFIFLCAGSWVLLHRMTQHPSTPGSLLAAWLPDYQCTRRPQSSTGPQAPLDDQQVARMPVRHTRIAVASGYQHHFEVYLTLVSTLERVFGKLGARGAGASVSVYSPPYGYRFQEVADEIGLHHGAHYPIERLVPDLSDVTGDGAIDMVVFGTCELDINWFSEALLAAWDARDEAHKFQLVCFAHSVRDDTQWQGHITEWARRGAFRVLTLGDQVTEGYRRLFAGLADDPDPRIYTAGYEYVAVDTHVPVLDLPHLPPPPANRTLARAVIQGTFEAYRRDYDTIFRELIADLTVDPGVWGYLPLDGRAAFAPDPHAPRARFELLLVGSGEIEVPGELAGVVSVHRDLDYPEFYALIAGADVLLPAFSQFGYYDNQASFTTSTAVQLNIPMLVTNRTRRAYGYLDDPRAVITRPAAMHDVAALRALRTGDAAPFDDDGGPARVRAAVREMLAAGWVRPRAGFEAYKREVWRRNERVSERLVRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV82</accession>
    <name>A0A401GV82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0900240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617060.1">
        <property type="nucleotide sequence ID" value="XM_027761259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV82"/>
    <dbReference type="STRING" id="139825.A0A401GV82"/>
    <dbReference type="GeneID" id="38783064"/>
    <dbReference type="InParanoid" id="A0A401GV82"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="597" mass="64832" checksum="B70CCC7B6C28841E" modified="2019-05-08" version="1">MSNVDDQYIPASSPSSSPPSSPSFDPLDSSPPSSPNLEAVATPPQSPEVVHPFAASTKATRRPHLHEKRTRVSQWASNSLSRGGSFESHDLDERAGNVPQVVDPFAASAKHYWKPPRREKKLSRVQSTGSAYSDSTIIDHDDPFFVLHPSAHDNHSVLSDDNNMNKNSQSLTAEERELDIWEVAIAAAVDRSNGDINLSQSGLFGTPLTIIPPSIADLAKLVVLPEDESGDRRRPVPSPPPMTRTFTRAVTVPDAVFSHPPAFGPNTGRIGGLSKTASSSYLQGTAEPRRHGIQLNLARNTIPKLPLELFLLSGLTMLNMHANALRVIPPQIAKLTNLCELDVSQNRLEWLPAEMLKMRLDKLSVRGNPWKVPTAEEQETGNKGGKRFISHTTSCFDIPHLTEYSLRTLLAPVESMGGVTALEALYAIPLLEGEHPPSVLNTLRACVPNAVAKPPPPEPKPSQPPPKVQRVSHTDDVHSRLHIRHREIQVQEKGKEQDKETPPGIGLCPAPAHRAQGASAAVFVQHAVERFTWELVVAGLDVGTQGNKMGVPVRWRGCGTDCLGFLEDEGGGGGIEDVAMGTEVDVEMVDTDVDMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVH9</accession>
    <name>A0A401GVH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0802760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616667.1">
        <property type="nucleotide sequence ID" value="XM_027760866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVH9"/>
    <dbReference type="GeneID" id="38782671"/>
    <dbReference type="InParanoid" id="A0A401GVH9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="12007" checksum="13D80C6E9BCF3D0A" modified="2019-05-08" version="1">MNETDNEGVAEKGIAVHEDCDDSAFRAGAAWTDNMSDANGSGLTQEIERIVVSSLSLVNPRAIASTPILLSFLIWIGVKRVQVDHSLLILLQQTKAWPSDLLILWVSFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWM6</accession>
    <name>A0A401GWM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0904610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617495.1">
        <property type="nucleotide sequence ID" value="XM_027761694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWM6"/>
    <dbReference type="FunCoup" id="A0A401GWM6">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWM6"/>
    <dbReference type="GeneID" id="38783499"/>
    <dbReference type="InParanoid" id="A0A401GWM6"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="564"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1127" mass="123938" checksum="EEA91ABF930F7901" modified="2019-05-08" version="1">MAVLSLPLTFQNSFWSQDYRTGLEVLYTQLENGVAENAEIVAFIKARAIAESGLATALANPVSKGSAFAQEDGVSLHLAFRGLQEESVAQGKAHELLAKELRTSVAEPFEKWATGYKERLRASKGNVLEHWMLAYEFAQGDVGKLKDDYHTKTRRADEAEDDVRFAPVTQPPGDKYTISPSLVPKDVRPRRMPQRQPTVTERISARFKEFRLGTTTAPHTDDAQPEVQFDADTEEKEKSTPRVDKGKGRAIEGAVSPPSIASPPPLSPPLPKLVTDPVPPAPAPPMILAGISVPPADVSALLKRAKEELPLRAVRFPLLGEYQECFSGEEFATWLKENVESFGGDLDRAAFAARELTEKYKLLRRLGELGNDFENAPDAIYQFRSKAFDLGSVAVPAKPEQALSSPQKALSPLAEEAKRTTASFASLVSRALNTNQNGNEPSHVKLRRDAEVADREYRIAIRKLDRQRLALEERIEDTLKTLQRWELDRLRAVKTVLRQYHDAVALFAKAYEPSLERSDTLIAAYQPEADIKALIEQHRTGPFRPTPQVYESVAHDESDVVFGLDLRRWADSGYWHASPTAGEEKRDEVPPVLTLLLAALNEAYPKLSSDIEKRKTWIYDVPLPGVHHLRETLNAVPPEQPLPNDVLGKYDAPVLASAVKLWALELDPPLGMFEGWDEFRKLYPTVGSYKADESPSNEQHILDVQIALQKLPKIHLLVLDTIIKHLKDLIDSTAEANGEDAREVYVTKLALTMGRTVLRPRQENEFSIQDRHPTLLFIDLLNKYAEILPPTILKKKRESERKVPVRRRTRPVDMRLSRSRISAGADLKELHAQQLAQRTGLKNAGSPPAVPAANIPILPQVAESPLPQKTEHDAPAVMLSAGPDSFDELPPAPPAHDAKEERVDFASIPPPPPLQAPIPKTPVIPPHPMFREPPPETDDAPPRPTFKEPAPEPASPEPPMPSFVEPPREFVTPPVPQPSFVDPPVEPEQSTRTPTAIPAVLRSGGSGSTSRPVSPRTSSLGSRSPSPTKPSTSPTLSQDRPVRGGRLTRGPRAPGGGGAVSSMVSNLNRQSIGARPASPANGGSGSSLSRPGSRTYTGHGKRSSISRVAEFSRRTMASDAEDEVVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWP0</accession>
    <name>A0A401GWP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617097.1">
        <property type="nucleotide sequence ID" value="XM_027761296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWP0"/>
    <dbReference type="GeneID" id="38783101"/>
    <dbReference type="InParanoid" id="A0A401GWP0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="89" mass="10155" checksum="0B16DD98B079233C" modified="2019-05-08" version="1">MAFHCFRPSFTRWRQGANYYVKYDTIIVIPQNLCGPTKRRLIFVSDISKSTSTSTAAPGPPSKIPRNLFIRYSSRVQSDAHPHPGLHQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWP3</accession>
    <name>A0A401GWP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0904990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617533.1">
        <property type="nucleotide sequence ID" value="XM_027761732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWP3"/>
    <dbReference type="STRING" id="139825.A0A401GWP3"/>
    <dbReference type="GeneID" id="38783537"/>
    <dbReference type="InParanoid" id="A0A401GWP3"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="344"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="441" mass="47287" checksum="046D56091BD125B5" modified="2019-05-08" version="1">MPPFYHFDRSQVPVPPSSASAQPNPVVSYTSLNNALNPDTRPATSDTAYQPSPQPAQSSSSQMASDSRYAYPNSQEVSPSFNYPPYAQYEPPQFQQQQNSSRATVRSASSQAHSPHQPSQPYNPPPPPSYPTQPPYPPPPYGVAPQPSGQWTGESWPHYPPPLPPSHVPPSQEASYAGGARPEMSPSSSSEHRPYPAAGPSRPDVSRNEERPARAPEAAPPPKVRKTRENDPLPPPAPAPAPASALPPPSPLGLDFFKLLDSYRLVMNTASALMQQDPSLTRSAPSPENMDRMLQAATYGVQTLDTASKLSPPEPPRANDRSPEEPDGQGHQPAALEQAETQPGTEGQTCLGCGATSTPEWRRGPMGPRTLCNACGLVYAKLIKKRSRGDQARTRGTLQGNSGMQGPVDESAQVSSNEGGSDDDDSYGSQDRRSEGYGGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXC3</accession>
    <name>A0A401GXC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1000720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617743.1">
        <property type="nucleotide sequence ID" value="XM_027761942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXC3"/>
    <dbReference type="STRING" id="139825.A0A401GXC3"/>
    <dbReference type="GeneID" id="38783747"/>
    <dbReference type="InParanoid" id="A0A401GXC3"/>
    <dbReference type="OrthoDB" id="2685413at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="570" mass="63646" checksum="491AD58058D041F5" modified="2019-05-08" version="1">MNVFNPKILDASIRDVTSGLADEQKVDVLLYAIGHLDFQRSRTLIENAVQSCLLINKLSPANATKARLMRAKARLASGLHVGAHQDLRAILALEPEHPGAKELMLQHVGDPGKSSVEPNSTPGFSTEVWREIASWLPPADLKTLLLVPHVLSRIASQLLFQKIDIYFTSEKWESQRSADILTRIITDPEFAKHVRTLRIFYQGRDIFPMTFQTGMLSNALPMLVNLKNVHCAMRWRDLLAVVKILDNVNIRLRGLSLMPSDGTSDLRLPKFRHITQFSIVSKGGSPSQVNDFLLQNKTSIRAIAIHNLSWTFPSEVISIRNLTHLDFLGAFPLDSGVFAEILQNGHQIESLRLQCVLDCAPSSQFRDFPRSLPFLRHFAFSLLGYSLNDHDLFPAVSDFLRDRKDLRTLQLTVPSADYAQRRLGYDATVWGVLPSLVGLKSLTATLPKDVAAAVAMWLVPRGVEALSLLAASSSTEALGFVSQLRPGLPPSLHFIGLTHFSAEDVTAVIETGFPMVRVARVGDNYYTVSRLDGKFELDEWPASRSPCKVNEWLDYYGCKDAEWRSPAEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXG8</accession>
    <name>A0A401GXG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617824.1">
        <property type="nucleotide sequence ID" value="XM_027762023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXG8"/>
    <dbReference type="GeneID" id="38783828"/>
    <dbReference type="InParanoid" id="A0A401GXG8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="48585" checksum="452C5D4D815298BF" modified="2019-05-08" version="1">MASDAEPPDTLDITMGESDEEDSIAEPRRPLISDLLDSPGSAQISLPLHSASQTPLMPRHTTPSLAAPFAPSNSPHEHLHRHTSPKVQASSGSVAPVEGSRALIPDPLAPAWDESRGSSSIHRRALISDSTPTAPGGMFDFDTPGISPIPQRALLEATPLPPPAHTFDFRTPDTSQLPRRSLIAEPLDATPRTSIHFDSQASMPMARGMLVDETLDAEPVPKLLDFDNSPPATPGRRRALVIDSPGATPVRSQVRWLNSPSTSPPKRRPLLDDVLSPPPPPSAPSHSPARTFDHSNFHHDAPVIHYMKGSIEPVTVTSRMPSLAALPDELPIHRPTHWEQVPGLFPDITQLLPMAVPGETNAASGSQVACLSRSFAQITAEADSSMDDDEGDSFAVSRHRAMLRERIVHLQHELNLTEDMHVANLNASSTVFQMGYILRDICGEAYRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXX7</accession>
    <name>A0A401GXX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pheromone B beta 1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1002980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617964.1">
        <property type="nucleotide sequence ID" value="XM_027762163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXX7"/>
    <dbReference type="FunCoup" id="A0A401GXX7">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXX7"/>
    <dbReference type="GeneID" id="38783968"/>
    <dbReference type="InParanoid" id="A0A401GXX7"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019331640" description="Pheromone B beta 1 receptor" evidence="12">
        <location>
            <begin position="20"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="371"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE87051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="59838" checksum="5FDE5D37157607B2" modified="2019-05-08" version="1">MLSLITWLLLCNIIQGINSLVWASNIAVHVPVWCDIVTKVLLGAWVALPAACLCLCRHLQNCARQVETKGRRSFLALDLALCVAVPVLYMAIHVIVQDRRFDLVEEYGCEPSIYISTPAVILIWLPPFVLCVIAFCYAFLALLNFRQAVRVTSLRNSSGFRVLTFIRPILTAFIIVSLILSSSAFSLHARIVSTAGLEPWTSWVAVHAQLSAIRVIPPTAGLELIRVAITWWAIPACSLVLISAYIVGFACGAREEVLRGYRYSPRWFRTDTSPRRTDLFTDPALDVRLNSSMMPMPVYLPTTDVNDTLRSTSSIKAKAAPLSISIPGHATVSPPTSSASDDSDGAFVQSTLNYVGSPTGREALGLPLLPPSLARPRKPAPLPLDQPISTIPPALHLTSGTTTASPRSILDGPWPRPPSAIPTPVAPIMISPPTPQPDASASGSRPASASSLSTLSTSLASSTISAHAYAQEPERGPGQPLGDSPTLPHFPPFGDAGVPAAAQSSTLAVPRRARRKGSKDRIVTRNLSLSSRPRERGAQYVNGFGPIYMTVVKETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYC9</accession>
    <name>A0A401GYC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1004370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618103.1">
        <property type="nucleotide sequence ID" value="XM_027762302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYC9"/>
    <dbReference type="STRING" id="139825.A0A401GYC9"/>
    <dbReference type="GeneID" id="38784107"/>
    <dbReference type="InParanoid" id="A0A401GYC9"/>
    <dbReference type="OrthoDB" id="2501127at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20688" checksum="E18EBB35F1F9FB3C" modified="2019-05-08" version="1">MLFFHPVRLLLYIFLWVVSAVLLGLTAARLYYTTHLPAFDPLNQGVDFYDPIVAELLFSSILTLFWATWVIHVVVRNFEWGLVVSFASELLGLSVVFVLWLVGAAIATNMWGDLHWCWIYQPCRLLTALVAFAWIGWITILVLLVLSTLFVTVNRALYAPLHGRYDFRSHFRNAGRTVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ78</accession>
    <name>A0A401GZ78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618381.1">
        <property type="nucleotide sequence ID" value="XM_027762580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ78"/>
    <dbReference type="STRING" id="139825.A0A401GZ78"/>
    <dbReference type="GeneID" id="38784385"/>
    <dbReference type="InParanoid" id="A0A401GZ78"/>
    <dbReference type="OrthoDB" id="2940229at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="704" mass="79083" checksum="56E9FC6A98E44141" modified="2019-05-08" version="1">MLKRVRAVADDGVVAATPRKRARFDPSIHSSPSHARLIMNTSPFPLVPASTPYTTYTFQTPSSHSHAHKYSKFSPPSDSPSNPFGALQALSLPCPLPFGKHLALRFQLVCRGEDADDVFRIVQVPTNYSFRILHKLILFLFASDARMKAPVPGRIAIPHRRSERKHRPPVHLALAPPVLVGGPRQSGKGKKAAQPVWQGHSFDVLQGIAPYCGGYKRGLIRQGEGSGVLYARLSALRERQLFAELQEECAGSGDEEDIFGGGETPVDVGRVADKNRKKGKGKEVDKGKKKSENGKENNNKTKVEEEEEEDDGWMWEAEDDYTIGHVWRTGPDARRGIIYHHVPGVSVHITMNTQRLPIRKGVSNRPFVFRTRGSSLGAVRISHVAAPTTLPQYDPEDEEDWEVHTDEARLRRFNRRDTFVHFLAREAEREKPQPAHPIIPSPPSTPTKPNKVLVTPVAAKRIRRPLTPYFRSVGREDTLPPSSPPPTSPQEGPSDSGAVAGPSFRSSIFPHRASYPSIHELSSRSSVSTASSPFPHPTPITLALPTFTPYPTHPLHRRRVERATRRLRRLTRNGLSYMSSSSEEEEDQLKDDDQGDLEAEAEEENQKQLEREQQHEKEEEHRVRKTESSITRSRISQAKKIQKENSPEFDLAPSRPRVENSPELDFGSSLYVEESEEDEEDQLFEDQYALPGEEWDLFAEDVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZA3</accession>
    <name>A0A401GZA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618408.1">
        <property type="nucleotide sequence ID" value="XM_027762607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZA3"/>
    <dbReference type="GeneID" id="38784412"/>
    <dbReference type="InParanoid" id="A0A401GZA3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="78" mass="8642" checksum="5CD72E1D5053E31A" modified="2019-05-08" version="1">MPYLFTNSSDESGGPPSARDVHEAKPRDDDWNKLKWKEEDMLLGTKSGGHVEVEDADEKSGCSSIHLQEEDVPVGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZM2</accession>
    <name>A0A401GZM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1102790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618515.1">
        <property type="nucleotide sequence ID" value="XM_027762714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZM2"/>
    <dbReference type="GeneID" id="38784519"/>
    <dbReference type="InParanoid" id="A0A401GZM2"/>
    <dbReference type="OrthoDB" id="2804135at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="521" mass="57021" checksum="4DCF484DD0C44B3D" modified="2019-05-08" version="1">MSGYATRSRNDQLNYRVLAGIQAEGQKPRRTSAQVVEERQQVDARRREAEAKRQAVAQRIAELEEEMARQDVDDHEGAGCTLASFTGFRAGPSAVADVDAAGLREGNRIGANGSKAKKLSRADVEAAHKRKEVTTVVKKVGQKKENRASVIGSTALAATRKRKAESQEVVGATEHHAKRSKATHAGVRSMWTPHSSKNTTSTAAKVKTSAASNGASMGGIIVNAEATLVEDSDEDDLVEHVAVGNGKAIHPHTTLGVVEINPRARAVDSQPVKRGPVIAIRCPNGSRKFTNTDLPISSASMWVWRHQLIPHYLETLGESASNPWNFTGLNLVAILQLEELWDEFFPDIPLIVVPHEPVYDIAQQKVYEWRYSIAKAGVAAVSAFFEDEDNGLMTEEERAAYIRYVIGPNLPFRYAGATMKGRNGKPQYVEHALRQYESGVFIKTDQKFSQDIHGRLTDYYMLSIASLREATWNKIINATAPLACLSSIMPGDLGGDEWDKVVDAECGNIDDESASDGDMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZV0</accession>
    <name>A0A401GZV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1103720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618608.1">
        <property type="nucleotide sequence ID" value="XM_027762807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZV0"/>
    <dbReference type="GeneID" id="38784612"/>
    <dbReference type="InParanoid" id="A0A401GZV0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="159" mass="17288" checksum="0197022286337718" modified="2019-05-08" version="1">MNTAALLQAASSPGNPSSPPQPHTSTMSSMQAPQAPASSPTLIRMQTILKPSVVIVTFILPVIIVFMAWLKTVSIHFDVPSSAMSYTDDLITITIHRRYHRGTYKETNPEVCGIGVCYCPMTAIMHSFFSLLTPSSLCTLPFIYYIIPSVVPGCGVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZZ8</accession>
    <name>A0A401GZZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1104200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618656.1">
        <property type="nucleotide sequence ID" value="XM_027762855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZZ8"/>
    <dbReference type="GeneID" id="38784660"/>
    <dbReference type="InParanoid" id="A0A401GZZ8"/>
    <dbReference type="OrthoDB" id="2803682at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44778" checksum="871AB28D847A1264" modified="2019-05-08" version="1">MPKWHAVYKYILRDFTPNPPPEAIVTLHIPLRDFSDIDSLYWAAALDIPTSCLPNFSSYPLRWLCYLSFCLTGSRGDLKRSSQADSPHVNYDDQTALGESASFYFHPERSAFLIDPDMCARELPCETDTENSDGDELWDHLMEREHAECVATGTPHDLCSAEHLIPASKGNKYISLLTRGRRYDDADDAIVDSINDPRNALFVNLLLRSAIGAMDAAFLQTPNFILKPEHLNSQYTGGSHTFLHYFPRPSEIADNIKPYIPHGQPIRLPEPRNRDTWPPETIFAACYGCAALNTWPVHSFVERVREEWVGKGEMPLDLPDDANRKQPPMHVWSKAAQERRAERSETEEVWDILTMYQELLHGAAQERGQQRARENTRERVNTWLHTTEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H041</accession>
    <name>A0A401H041_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1104260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618662.1">
        <property type="nucleotide sequence ID" value="XM_027762861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H041"/>
    <dbReference type="STRING" id="139825.A0A401H041"/>
    <dbReference type="GeneID" id="38784666"/>
    <dbReference type="InParanoid" id="A0A401H041"/>
    <dbReference type="OrthoDB" id="2785713at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="455" mass="51822" checksum="51A0180AF7557ACB" modified="2019-05-08" version="1">MSVCSSTGSRAFSSSRLDEHIPQTMSFLSLNDDVLEIIISFIPSPDAWRLAQTCRYLYDAAVCQYLSIVTINSWRQLIGFSSFVLAEPSRKLYIKALEVSLRYSQEYSECIPAFIEVLRGAGSLRSLSIEDEHDLLRSLPSLRSALAAIPNLERISYFRVGSKFLEVLTHMVSRPRYLKVSLFPYDDEVPFWHALENLTGCLETLDFSPIQSLNPGINNVWPHVHSLSVRLHDGCRSLYHLVRAFPNVRRFKLNCGGVYDTRPHWASLDEVESNFPFTLFSRVRRLLLHEDDFGDPDGLSNMVLHMLRHTSPVVLSFSTWRPRLIPHLQDLTPRLKYLKVVTHADADTEHQQSLSIARDLHGLQLTALCICYHSSWMTEPQCDLARLLGLAQQVAATLPTLGYVGFDSSLGWRDERRVPRWFCVVSRDGDVPQLDLLSRGQGEELELRLYNLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H057</accession>
    <name>A0A401H057_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1200040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618693.1">
        <property type="nucleotide sequence ID" value="XM_027762892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H057"/>
    <dbReference type="GeneID" id="38784697"/>
    <dbReference type="InParanoid" id="A0A401H057"/>
    <dbReference type="OrthoDB" id="3071324at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="485" mass="54459" checksum="817413A3570DA7AC" modified="2019-05-08" version="1">MGSNYSTLRSSSPSILGKRSTLDDALDAPPAKRLMSERCGFVEDAQVLSKRRHEEDDSQRHKKLKEDDSNSQTDKRVVVHATHHPVNSKHVFPFLMLPVELGNIILHILANDRDTLYTLSLVSGLLRVYVLPLYLKAAGFIDSSNNVGPVITYEHTRPVIVWRGMQGLPTPPSMWICIIANAAMAKCQLYGLAGFFISSRTQLAISNIVIELHNARLALATCKFLQTVATDLRAIESPEDIPVVNSGLFYPRLQKMQVKSAVFFSAEYISWMVHTLNSAALTALDLQLDNRGSPSWRLILPHLHMEHLETLYIDGALPINTIFRFLLHHPSICELRIGHFTRPGFLPYTAHPPNMDHLEVLVGSHDYIIPLLARGLPALQRLVVILDHPFAIGLFLNSELRGVINSARRCTRLQELDIALPCGYIAQPESDSFFIVDDPQHLRTKRGLSNVRTITIRATWDADEFTLSSTHLSVLISFLRYDTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H074</accession>
    <name>A0A401H074_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1200500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618738.1">
        <property type="nucleotide sequence ID" value="XM_027762937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H074"/>
    <dbReference type="GeneID" id="38784742"/>
    <dbReference type="InParanoid" id="A0A401H074"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="420" mass="45339" checksum="6F63887F1A8C8DEC" modified="2019-05-08" version="1">MEYSHRLSACLQALDSEAPFDVPPYASMYSEGPISFGVTSSPAPHGSPDSTMSSDSVDIGASFAFYTPSVVSAGSMLGLMTSSGSSLTMPVVPNYLGNDIFGNLDSTSPRGRPFVGDTFLDQPIDGYDSFLGSPSRLGGRIHSPYSPSLSTSDHHHGGADDYHDAHNRPPSPSNISASFSEHSSVTSPAEVLSPIPALSLPPLPVTHASRAKAANAIFQQQVLDTQQITEGESDDSESGDEYVPSRAGPSRARPSRAKPSRPAPARRQGARTRRYAPYARAVSPTVPSPSSQPQPQPQFERATPRNEQFDGEVRPPSPGATQCKYCPASYKRWCDLDRHVRSHDGNARRTLCGGLPKAEAISAGVNVKAEMPYVYDGVEYYGGCMKEFSRKDSLSRHLQRSKCRVGSLTTQYNLERARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0G7</accession>
    <name>A0A401H0G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Voltage-gated potassium channel subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1201280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618816.1">
        <property type="nucleotide sequence ID" value="XM_027763015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0G7"/>
    <dbReference type="FunCoup" id="A0A401H0G7">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0G7"/>
    <dbReference type="GeneID" id="38784820"/>
    <dbReference type="InParanoid" id="A0A401H0G7"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="183"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="510" mass="56242" checksum="BBE76AE8FC9FF4B4" modified="2019-05-08" version="1">MECQLSSLWSKLASCSILTLSGGVFYISSRHRGIYGARALIQKAEWITISAGFIARIGGHGTRPCLIKSLSGYLGHAPSGHLNVLYVALTCCSSVAPEMMDSWFGACYCQALVLLVPVLHSMGTALRNMSSTRFVEQVQVSVHVIWSLRARFLVQTWNRTRVFPMIPRPLLGPSGLRVPLFSLGGWLTLGGSVTGDPVREIIKTAFDNGINMFDTAEGYAGGKSEIEMGRVIKELGLRRTDLVITTKLFWGTHGSPNDTGLSRKHIIEGTKECLERLQLDYVDVLFAHRPDVSVPMEEVVRAFNFVIEKGWAFYWATSEWTAQQIEEAHLVAEKLNLIAPIAEQCKHHMLHRERPESEYDPLYRKYGLGTTVFSALAGGILTGKYNNGVPGDSRLAVEKEKQFQDTAAQLRTPEGLAMIAKIKTLSEFAENELGCTVSHLALAWVAKNPNTSTVILGASKPEQVLDNLKALEVLPKLTPEVLEKIESIIQTKPAPAPTFGRPPLDKFGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0I3</accession>
    <name>A0A401H0I3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1201270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618815.1">
        <property type="nucleotide sequence ID" value="XM_027763014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0I3"/>
    <dbReference type="STRING" id="139825.A0A401H0I3"/>
    <dbReference type="GeneID" id="38784819"/>
    <dbReference type="InParanoid" id="A0A401H0I3"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="51657" checksum="A3A909D199462E31" modified="2019-05-08" version="1">MNTNGISKDPEIPQAPSSATSETHEEAWEDVQDLNYVRPALRPARGGNPRRRRAGYKTTLVAQTAPSRKAATLRPLHQDAAEPPVIDQHQVRRALRVVAAFTIRYVGDVLTTAVRLLRKPLGILLFIWILGVLFTTLNHTFRTVFSPFCIIPGISRSALCITPQPNGGKKQHSVDFGRLMDVQGSTFEQLLDDSVDSSGLSLEIKKAEIATSDLIVVVRASNLKSKELLADTLAEFHETGKKAGRGLQTFAAKTAGAVDNIMAVNDFAMRQIEAANVKPSALSIVWPFSSRPQTKEVVLRTFRAAMDVLATNMQRLIIEAEANLLNLDRLEEILVTLHDIVHREDASISSAHSELLSELWTKLGGNKREVRSQRQHLMLLRNLTAYRSRALAHVVGALQTLQAMSADLEDLRERVAAPELMGEHIPLEVHMKSIGSGIERLKEGKMKAKERQVQVLRGILGTEDLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1I9</accession>
    <name>A0A401H1I9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1301100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619208.1">
        <property type="nucleotide sequence ID" value="XM_027763407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1I9"/>
    <dbReference type="STRING" id="139825.A0A401H1I9"/>
    <dbReference type="GeneID" id="38785212"/>
    <dbReference type="InParanoid" id="A0A401H1I9"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12215">
        <property type="entry name" value="ChiC_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.20">
        <property type="entry name" value="Carbohydrate-binding module superfamily 5/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="Carbohydrate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019091761" description="chitinase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="32"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="333"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE88295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="482" mass="51242" checksum="FD1F0D7E9579AB30" modified="2019-05-08" version="1">MARNWFTVASRGLSLLSNGALLAYGFDNTRQDNLAVYWGQDSYGATSSNTAYYQQAINYYCQDDVIDAIPIAFLNVFFGEGGYPSIDLANTCSTADDPVFNGTQMPDCSFLASDIEACQSAGKIVTISLGGATGAIGFSNESQAEEFAQTIWNVFLGGSSDVRPFGAAVLDGIDLDIEGGSTSYFTNFVSTLRGYMNGGSKQYYITAAPQCPFPDAYVGSIIDAEPFDAIYVQFYNNYCELTEYNDTNDWDFSTWDNWAKTTSPNPSVKVYIGAPAASAAAGSGYVDAATLGEIAIQTREQYSSFGGVMLWDASQAYGNDRYDAQVKSSITESGGATTTPTSTPTTSPTSAPTTSPTTTPAPTTSPTTTTPPASTTTASGGTVDCTGVNTWVSNVAYVGGDQVVYGGDLWTAKWWSYADIPGGAAGDWTNDGVCAATNLQAGEYVKVQYQSKEAPLTAQAKATVARFSVPTPVQVWSRFFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1K2</accession>
    <name>A0A401H1K2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_1300870</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619185.1">
        <property type="nucleotide sequence ID" value="XM_027763384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1K2"/>
    <dbReference type="FunCoup" id="A0A401H1K2">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1K2"/>
    <dbReference type="GeneID" id="38785189"/>
    <dbReference type="InParanoid" id="A0A401H1K2"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="791"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="526"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="605"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="695"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="605"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE88272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="858" mass="97425" checksum="29A0BD6DA8CA2EF7" modified="2019-05-08" version="1">MKFGRKISNDLYNEWRPFYINYNSLKRELKDRTTSRNWNDVDELEFTAMLERELDKIHDFQKAKTQELSSRIKDAEKAVKRLVTSDYVNGHEPTASEATDAEAQHRHHVTQDAGSDDDDLDEDDAMSIDAADDQFLALEEEVATLVADVHDLALYTKLNITGFMKILKKHDKQTGRPLKPTFIQEYLEKRPFYKYNWDSLIVKLSKLYDLVRTRGHPVQGDASAGGSQSAFVRQTTKYWVHPDNLVHLKLAILRHLPVLVFNADREFDPKDAAITSIYFDNEDLELYLGRLEKTEGAEAIRLRWYGNTDVKTIFVERKTHREDWTGEKSVKARFPIKEHLVNAFLCGEYTMDAEFEQLVAKGKKSQQEVDSMIQLANEVQYSILTKQLRPVMRTFYNRTAFQLPGDARVRISLDTELTMIREDNWDGRVRSGDNWRRTDIGIDHPFEQVAVDDKELFKYGVLEVKLQTQYGQEPPQWVTELVSSHLVEAVPKFSKFIHGCATLLPNRVDLVPFWLPQMDTDILKPDTGTLAIERPTVTSSRGTSDRQGSSGIATPDHAHQHYAEPVSEGEEDEEMDMAPAKDEDKRTGLSQDAVAAAAAFREKALKERQEEPQRTPSAKSHDAHADEDAGHDGDVESEGEDEEAEADERTPFLKSRRASGKVGVANGTASRVLSIDPLAPSSAFDEELRDRLRQDAERQKKEHVEEAVDEEEEEEADQQEGPSSAAAWGDERVLDRSLHAPPGKRIAVPVRIEPKVYFAAERTFLKWLHFAIIIGTIATTLLNFIPPDDTVGLISAGLFTLVALISIAYSAVIFVYRAYRLRKHRASGMYYDKYGPTMLSLFLVAAIAANIGLRLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1L9</accession>
    <name>A0A401H1L9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619202.1">
        <property type="nucleotide sequence ID" value="XM_027763401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1L9"/>
    <dbReference type="STRING" id="139825.A0A401H1L9"/>
    <dbReference type="GeneID" id="38785206"/>
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    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="165" mass="18423" checksum="B724986FB9E15DF8" modified="2019-05-08" version="1">MLSLTARTTLKRSAAAARRPAVAVCTPRSYSSTTNDNDPEVLELEKQRNLSKSQHKTSTTVENAPGWNEYLASASEAAVKADRSEIPTSELEQRTIEHIRNRHHSEHTSSASSKTELLSNGEGTIESREATYERDEISGPLKGAPAHETIEREYEYEQKQTRKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1R5</accession>
    <name>A0A401H1R5_9APHY</name>
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        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">SCP_1301630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619261.1">
        <property type="nucleotide sequence ID" value="XM_027763460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1R5"/>
    <dbReference type="STRING" id="139825.A0A401H1R5"/>
    <dbReference type="GeneID" id="38785265"/>
    <dbReference type="InParanoid" id="A0A401H1R5"/>
    <dbReference type="OrthoDB" id="2670057at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="51663" checksum="504AA9492286F7FE" modified="2019-05-08" version="1">MRVPRRHFWKRQEGPAAPSGIPGIGGVATQSQQSITATGLMIDTSASAATYSAPPLDGSSIPVVTSTPSSTSSVNLATSSPASASSASSGSNIPIGTVIGACVGAFAGLTLLLFLCVFCCKRHNREKSRGDPSSLGSTRGNADQPRNRDSTWKRLNGDNEDKWEGMPGKRDVRRDTEMTEKNFSMFKKSPSIYTTRTAKTISDEDHGYDLPPFEFSKYHPSLAAELALQQPPRPFTERQDSGVSWGGSTAADESFLSLHSMRADSGTMSPTMVMAKMTPPTTSSPVHKWESAEVLTMGKDDMAGPREVQNPFMDVHEERRSVVANPFFNAQEMQRSRTLTRSRSNSRTSRTRSVSQGHSRNTSHSTIGRSQSFRASNPFIDVHEIPVSRIAPPAAIHVQHDSVASGSSANLFGDHAMRSLIAALEMTQEEVEERLRVVSMQASTISGVSSLTGLDDEETDIATVRKFPMPPAGNRSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H213</accession>
    <name>A0A401H213_9APHY</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1302690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619367.1">
        <property type="nucleotide sequence ID" value="XM_027763566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H213"/>
    <dbReference type="FunCoup" id="A0A401H213">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H213"/>
    <dbReference type="GeneID" id="38785371"/>
    <dbReference type="InParanoid" id="A0A401H213"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="481" mass="52055" checksum="7595A5EF57302CAF" modified="2019-05-08" version="1">MAPKKAQKMSLNEFLGDNTLGSWADEMDALPTAPAARSDEDRARPSDRRRDDFLSSHPDRASGHFHEDLPLPTEPPFTAFIGNLAFDLTEGELEDFFGGLQTNSVKIIKDRDEKPKGFGYIEFSELEGLKEALTKSGASLAGRTIRVSVAEPPKERSGFGGHSGFDDEAKFASNWRREGPLPDLPSSRDASRRRDGHQSMREPPPPSVSDTASDWRSSRAPARSSTTTSLDSESSFRRRGSGFKEGVPHGSAETEDSWTMGSRFKPTAPSGEGPGSRFGSMRGVVPPRDAPSPPDEGDWRRPRTLSRNSTSPSGSTPPTPQLARRKLELLPRSTSASATPSPLASPNPSTTSSAHHRSNPFGAAKPVDVSAKEMAAEERIEKERETTKERVSHHTMSRTSSHTASLRDYPTAHATPPASAVASPTTPPLEPHKSLPSAAGANVRPSFSFANVAAGKKEYANDNVDGDELQEIIEQTEEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H264</accession>
    <name>A0A401H264_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1302990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619396.1">
        <property type="nucleotide sequence ID" value="XM_027763595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H264"/>
    <dbReference type="FunCoup" id="A0A401H264">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H264"/>
    <dbReference type="GeneID" id="38785400"/>
    <dbReference type="InParanoid" id="A0A401H264"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="820"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="976" mass="107915" checksum="84C0E68B31E7DE2C" modified="2019-05-08" version="1">MTHLLPPHADLNLNHSSLQSALQIDPNQQPPPAQQPQAPPLQPPPQSRKRRKADTNGDDGPHPAEPRRLRRSHEACARCRSKKIKCDSKHPRCTACATAGTACHQEDRHRQTLTPRGHTERIERQLLQCDALLKRRIPDFNLDSLDDICSREGIEVDSSDNALSTTFQFAQPPGGGGSNRPYPLRTEAPPPQPGSPPRTYPYGPPGQPMMHHYGAPPMMPYGPPPPGYGPPPPPPPHMAMHGPPPPGYNPHILPAFQHPLQPHSSMQRSPSSHDIPKGQDPLSHDMSSTQALAKSFGVHSAIVNEVKMSVMDREDLAVGSAGLTSGRDRDVGEPSAPRDATKWFSVSMRRDSTAGHPPSGLSGPASPSSNVPVWLPKDRTMLRRVLDVYFTRLNFHRPVFTRKEFEHTLDALYEGQTLQHDPGYVCSLYLILALGTLSELNHRVSGMEKERSQNMASPTTPKKLMPADWPEHEEFFQSALAVKPDLRVTVSSLQALILLQWYLYTERQGRTLWRLVGSLVRLSIELGLHHDPTSQDNVFSEEECQLRIRLWGIVLVHDRGTSILLGRPLAIAPSDSNTPRPSRSKSGSSDISEHFVLSAPIAEIQADIINSLYTPTRQSADAIMRHATRIIKSMVEFRRQLPDTYKWYFSGTEDWPLERRIQLVNDITEDQGLTLLKIGITRILLLRALFSSKQLQYHHRHRALLDAIVMSHNIIIVHNQLIRFPDIAFFVSPIPLHIAAMVILFGRMSGCDPIPRQVALEDVWMALDMLPSFRWRWERKDLNGGHPLIAKVAEKVLGVNLHQVAPTAAPMLMPEQDWDADSILSSKPPPGTQQQGVQPQTPTMGPAQYPAQQGAYAPPNGGSSGTGSPGRGGKGAPGTPADKKLAEVPAALFYPFYPETQNNAAVVAAAGNGGNGDFNHLLAAAAQPMSTYGYQPSQESYMLEEKDTSAPASSTGMLWMNHEQRPIPHFPTQTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2R3</accession>
    <name>A0A401H2R3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619596.1">
        <property type="nucleotide sequence ID" value="XM_027763795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2R3"/>
    <dbReference type="GeneID" id="38785600"/>
    <dbReference type="InParanoid" id="A0A401H2R3"/>
    <dbReference type="OrthoDB" id="2747916at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="217" mass="24489" checksum="5C71FCAEB11C677F" modified="2019-05-08" version="1">MPDMPSDLDCIYQEAIFSLECPESHSYSSLFFQSTEENHDSCFMHLNLPQSTVPGAGNIKCSLALFEVIGQIAAKDCYLTKFGDEWLFPEDEESKTAYSCWIEPRCADMVSLIHWRNVARGLDMIVVAAPAPIETIHTIRADPETDSVKIQVSWRPLAGQTVEDTFPLYDSAGNRRVPASEEEVPFGQPVHVLFHLECVMYEGIRYLFAHLLGVREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2S6</accession>
    <name>A0A401H2S6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter abc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1401070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619615.1">
        <property type="nucleotide sequence ID" value="XM_027763814.1"/>
    </dbReference>
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        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2S6"/>
    <dbReference type="GeneID" id="38785619"/>
    <dbReference type="InParanoid" id="A0A401H2S6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="333"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="744"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1042"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1358"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE88702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1618" mass="178787" checksum="6CC223A4BBB83E39" modified="2019-05-08" version="1">MWGLVQGSEHRILYAQQWPTGIERTGNASGLYTLLQSQQRILLDPTAIPAYVVSASILTLLVQLALQSKTSNESSVILTGHEGTETSNASEIDGIRSTVAQRIKQLGGNTIFAFKVFRLLLSVILLALSIITLRLADHGPSPESIESSMWFQNGVCAAFGYASLLALVSVTANPSHGRLLIQHGNLVLFVMWALYLYRDVWPLATYVLSPADIQEGPLLWAKLSMLTLAAVVIPLCVPREYVPLNPKEPLSIPSQEQTASILSMMLYTWLDNTIITANRIAHLSTDQLPVLADYDMAKNLVHRSFPYMDPFQLRRRRHMFWGIVRVFQTDFSVMGLMLFLRTIADFGYPIGINLVLSYVEIHGKDSVVRPWVWISFLFIGPCISTICFQWYIFISTRNVARITAIITQLVFDHALRARVKADVNEASIGTGISTAVATPDNVSETEPGSSEIPQEHSGGSSEEGEEGSAATLSVDTSSMKGKQKKKASLEDSGSTKPEPTATATSDEKGRDMVGKITNLISTDLNNITEGRDFLFFIIEVPWKIGLCIYLLYSLLGWSAFVGMAVIVMAIPLQAFFASKIQGYQKEKMKKTDTRVQAVTDVLGVMRMIKLFGWEPQVEEQLAQKRNDELKYQLKFKLFNFFNNYMTHIVPILTIVVVFVAYTALMHQELTAALVFSSIALLDMLRRALVGSFRTLPQIIAGKVSLDRVNNFLYETELLDAFSDGADAAPVNSLFREDDEDVIGIRNASFTWANSNDGTLTPGPRRRNFVLHIDDELTFKRGHINLIIGPTGSGKTSVLMALLGEMHYIPSGPDSYVLLPRAGGIAYAAQESWVLSETIRDNILFGAPFDEERYNKVIEQCGLQRDLSLFDAGDKTQVGEKGLTLSGGQKARITLARAVYSSAEVLLLDDVLAALDVHTAKWIVEKCFKGDLIRGRTVILVTHNVALASPISEFAVSLGLDGRIHSQGSLSKALEEDQELSAKFVEELKVEEEIIDEHTDAKAQQSDGKLFVSEEIAQGHVGWPAISMFVNTVGGRFPAIFWFVTIGMLFVDEVCEVLQPWFLGVWARQYEDHPSSEVSITYYMSSYSLLVLANVAAYSISYVVFLYGTLRAARIIHKRLMNSVLGATLRWLDVTPTSRIVSRCTEDVNTVDGTFSDYTLYLMSITAALIMRLVAVLVMSPIFTVPSVVLAMIGGWCGQLYVKAQLSVKREMGVAHAPVLENFGSAISGLTSIRAYGAQDLFRKQGYHRMDTYIRSKRTLSNLHRWVSTRIEILGAVFSTCLATYLVYATSFDASDLGYTLNMAVEFSTLILWWTLMGNQTEISANSLERIHQYTVVEHEPKATDAGAPPAYWPTSGSLKVEGLAARYSSNGPRVLQDISFDINSGEHIGIVGRTGSGKSSLTLALLRCIITEGKVYYDGVPTDSINLDALRSNITIIPQMPELLSGSLRQNLDPFEEHDDAELNDALRAAGLFSVQSETDEGRITLDSEISSAGGNLSVGQRQILALARAIVRRSKLLILDEATSAIDYETDTVIQMSLRKELGKDVTLLTIAHRLQTIMDADRIMVLDAGRVVEFDTPRELLKKDMGMFRALVDGSGDKDKLYALVRGGSASTSWPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2X4</accession>
    <name>A0A401H2X4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1402000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619708.1">
        <property type="nucleotide sequence ID" value="XM_027763907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2X4"/>
    <dbReference type="STRING" id="139825.A0A401H2X4"/>
    <dbReference type="GeneID" id="38785712"/>
    <dbReference type="InParanoid" id="A0A401H2X4"/>
    <dbReference type="OrthoDB" id="3261476at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="312" mass="34907" checksum="9BD8429432C4257E" modified="2019-05-08" version="1">MLILSDNLTAVTTLKEDLKSRFEMTDLGEARWLLGMEITRDRPRRVLELSQHQYVEKCLAQYGMADCRPVSTPMAQNQKLVKLSEAEIDPKPYQSALGSLMYAMIGTHPDLAFTVSALSQHAATPGKEHWIALMRVYRYLRGTADKKLVYCGTTKEKEPLLGYVDADWAANINDRRSVTGFVFLISEGAVSWSSKRQHSTAQSSTEAEYMAGAHGTKEAVWLRTFLSEIGQVQKGPTPLLIDNQSAIALSKNAAFHERTKHIAVRYHFIREKYDSGEIEPEYVPTGNQVADVLTKGLPREKHEKFSAGMGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Y7</accession>
    <name>A0A401H2Y7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1401350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619643.1">
        <property type="nucleotide sequence ID" value="XM_027763842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Y7"/>
    <dbReference type="STRING" id="139825.A0A401H2Y7"/>
    <dbReference type="GeneID" id="38785647"/>
    <dbReference type="InParanoid" id="A0A401H2Y7"/>
    <dbReference type="OrthoDB" id="3222238at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60137" checksum="410372F4950E0B2B" modified="2019-05-08" version="1">MSLHRALECLDVIEGIFQRFSSTREDRQTLARAARVCKAFADPALDALWETLDDIIPAFRLLPSLAVVFDEHGFQVDVTFGIIPQDAWDRFQQYARRVRKLTVMSPASALMEAPSRPLEQLAQRGGGQVVFPRLERLTWRQEYLSRSNRNILLLIPSSLEALSIQGVIRDSGGETSWQWLEASQDLLRTIFSRAPRLQAFAISGIVHPRALVSIRALPALRQVHIVSRIINLQAIRVLASFPYLVELSIHARFTIPDNSGCIGFPVLKDLSVRGTQMEHTPELVNRLPSIELTHLLSTILSPSVRTLSANIRADEDGQLEPLLSLIASKYRSLRVLSLEVDNAAPDTRSFSGVLRPLVSLRVLRIIRIRLLYSMLLPAELLVDMAMAWPEAIEVTLFAETPSIDTSIPVDAVYVLTEFARLCPKLETLELPYLDFQHPPSLDTLTATKGHGLRSLGVSAYSNMSIEDHAQVAHFVDTVFPKLAIDSQLNWLPLEEGYDSRMNWKRVLELMKELRRERESSSGQIGTRNSLGESNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H391</accession>
    <name>A0A401H391_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1402800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619785.1">
        <property type="nucleotide sequence ID" value="XM_027763984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H391"/>
    <dbReference type="STRING" id="139825.A0A401H391"/>
    <dbReference type="GeneID" id="38785789"/>
    <dbReference type="InParanoid" id="A0A401H391"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019409432" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="83"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="334" mass="36493" checksum="38FCB89B736650C9" modified="2019-05-08" version="1">MPTLSTSQWIGLLSIPAALLLAQQLTTLSEPTPLTIHRSLSSLPPASTARRIYPEDFYEGGAYVQFPNGKVRYWLIGPEDGTRIVLIHGLSIPAFIWRDVAHHLAENGFRVLLYDLYGRGYSDAPQTEYTTQLYTTQLAMLLQYIGWKRVHVAGVSMGGAIATSFSAQFPHLVSSKVALIAYVGLYEPRDIPLKFKLLSSPLVQLVTSSAPARAYRQYLSQNNVHSGSVVADAEALVCLQSAYLPGFDHAIASSLREGPLRGLAPAFAQLGRDAGKRVLLIWGTHDPVVPFVNAERVQGLVPQAELMVIQHGGHELTMTHPGEVGPALVRFFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3B2</accession>
    <name>A0A401H3B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1403010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619806.1">
        <property type="nucleotide sequence ID" value="XM_027764005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3B2"/>
    <dbReference type="FunCoup" id="A0A401H3B2">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3B2"/>
    <dbReference type="GeneID" id="38785810"/>
    <dbReference type="InParanoid" id="A0A401H3B2"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="170"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="305"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="384" mass="40683" checksum="4F0F021559F19F26" modified="2019-05-08" version="1">MSGDNGEGQHHHPRQPWSLPSNTGPRVGRVGAWSTSSSSTSRNSSDGRRIATLRDMGGSASSGGGHAHGGGDDDDEEDENGEDQGESWFAGGERSGISVQNPGRPGAVPGGDIVRDLLRRAAEAGPPPEVESGPHVHSSVFTGGGHTLGSDEVESVYVPDPNAPEPEEETAIRHLTFWREGFSIEDGDLMRYDDPGHAQVLAEINSGRAPPHVLNVLPGQPVELRVVKRLQDDFVPSAKVQARTFSGHGHRLGSPVPSFAPAPAASGSSSGGGAMPGSFPLSTSRSPAPPAAERSSINTRFEVNQTLPTTSVQIRLADGTRMVCRMNLSHTVGDIRNFINASRPENNTRPYTIQTTFPTRILEDDAQTVEAAGLVNSVVVQRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3B9</accession>
    <name>A0A401H3B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Transposon Tf2-9 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_1403110</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619816.1">
        <property type="nucleotide sequence ID" value="XM_027764015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3B9"/>
    <dbReference type="STRING" id="139825.A0A401H3B9"/>
    <dbReference type="GeneID" id="38785820"/>
    <dbReference type="InParanoid" id="A0A401H3B9"/>
    <dbReference type="OrthoDB" id="2729552at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="543"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="15">
        <location>
            <begin position="842"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE88903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="888" mass="102155" checksum="0A99D1E1F5B5A31C" modified="2019-05-08" version="1">MASPFFFVGKKDGALRPCQDYRYLNEGMVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFKPMVMFFGLCNSPVTFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHIRTRRVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGDLHPCAYISQMLNSAERNYKIYDRELLGIIRALTEWCHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRQQARWSLKLSQFDLHLIHVPGTQMIQSDALSRRNGLDDSESDNEDRVLLPNALFVRSISPTLFDEIRNHAAKDLIVHEALEAIAHKGPFPMKSSLSNWEVRDGVILYKGKIYVPPSETLRHDLVRLHHNSPAMGHPGKFNTLELLRHEFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLMKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPNRIISDREPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLQLYCGNNPETWADRLPDLEFCHNTREHLARKMSPFRIMMGYEPRGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYVNPPPDVVDNEEEYEVEAILNHKTYRGHLRYLVKWKGYSSAENSWEPTHNLQNAKRILDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4J7</accession>
    <name>A0A401H4J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620270.1">
        <property type="nucleotide sequence ID" value="XM_027764469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4J7"/>
    <dbReference type="GeneID" id="38786274"/>
    <dbReference type="InParanoid" id="A0A401H4J7"/>
    <dbReference type="OrthoDB" id="2801156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="68987" checksum="D4C71FD209566DA5" modified="2019-05-08" version="1">MSDTSRLTLNIAYDILCLTSGRPSIWSFDVPKGITWAKFLMMIGERAIDEPLHNLLLYKLRKPAEVAELKRSRPQTIEEVEDIAEEVPLLVEVLHDPAQFSPDKVHVLVVVARPEAAVDHYKGEPPPGLELHPVEKAHLAAVKAEQDKHPIYNGRPDNCRSSPIVLYESAFAKLKDVLYDLRQAQPDRDFVAATAKLFLSAATIYNSESERESAIFDHIERLLDVTFERHVKAAMNRFSSKKDAEADTLVRERLDDTTHGEKKGIYICIEVKNELGMGRNSGLQGALTLLKHISQDGYEGIRNVSCCPCFVISIAGPYICFSGAVLVDIFIVQPFTDYIYLGGDPIMNERITHVAKLFSAVADAAMLLREHYRSLSPSTVPKHGPLLPSPAYGVKHPEGALEFVARFDYEGRKIDNYRRSLFRATFDGKPVLVKFCETYNERAHRMLADIGLAPKLYFCAQICGHVNMIIMEFVDSRDTHHQFSGKELPPSVMRDVKRAVDELHRSGLIFGDLRRPNIMVVTNHLHVVEAARTEKDTAADAGLGAMLIDFDWAGDDDQAQYPALLNDSGEISWADGVAPAARMKKQHDLGMIEKLNRHRSSAIVSYTRSLLAAGFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5V0</accession>
    <name>A0A401H5V0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1700880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620676.1">
        <property type="nucleotide sequence ID" value="XM_027764875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5V0"/>
    <dbReference type="GeneID" id="38786680"/>
    <dbReference type="InParanoid" id="A0A401H5V0"/>
    <dbReference type="OrthoDB" id="2744824at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="160" mass="18203" checksum="C9D9CAC9E54C5B05" modified="2019-05-08" version="1">MIIDNIQDELKDLSASSLISRSWLPRSRAHKLRSIVISTKDRYTAFEEIISASPVICHYVRDVTIDGHSCAVGPFGLLLRILLQLRRVESLTLRNCKRDQLLVDCRTRSGLSQGMMTAVYADCSSHVPSFMSYDCSTLAFDTKRYHWDAQNHFPALRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6E9</accession>
    <name>A0A401H6E9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1800370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620928.1">
        <property type="nucleotide sequence ID" value="XM_027765127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6E9"/>
    <dbReference type="STRING" id="139825.A0A401H6E9"/>
    <dbReference type="GeneID" id="38786932"/>
    <dbReference type="InParanoid" id="A0A401H6E9"/>
    <dbReference type="OrthoDB" id="2804728at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="184" mass="21121" checksum="E12303A244574C33" modified="2019-05-08" version="1">MEEIPSESLMRSLCTAQELVSKLLNAGSRESLDILHSLEDILVPTLSTVRCSINSFCPINHCPDDILGLIFQYSVALIDDTADEFQWPFSSFRPSSKLIDLTHICRRWRILALNLPLLWTHIGDRSSDPLLRAVSTFLQRSRMAPLKFHIRGKRHINIRSDSFKLNLSRMEELHVDYISDLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6S3</accession>
    <name>A0A401H6S3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1801700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621059.1">
        <property type="nucleotide sequence ID" value="XM_027765258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6S3"/>
    <dbReference type="GeneID" id="38787063"/>
    <dbReference type="InParanoid" id="A0A401H6S3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="49" mass="4905" checksum="7E92520851B0598C" modified="2019-05-08" version="1">MPPAVFGSSVQVPSLTTRNASRAPSSVGGSLANAVFGVLLCVSALFIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4T7</accession>
    <name>A0A401G4T7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608082.1">
        <property type="nucleotide sequence ID" value="XM_027752281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4T7"/>
    <dbReference type="STRING" id="139825.A0A401G4T7"/>
    <dbReference type="GeneID" id="38774086"/>
    <dbReference type="InParanoid" id="A0A401G4T7"/>
    <dbReference type="OrthoDB" id="3261851at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019245390" evidence="1">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="188" mass="20270" checksum="9AD890364A08F564" modified="2019-05-08" version="1">MVSFKVNRHLLLLSLLLSSTIPARTQQTALVALPTFSTISNTSVMASSASPEWLQEHLTTLLNSPYIHFKNPGPLGLRMGPGPIDLFSTRFNNMFTKDATGVVAGNEVDKAGLKESILALQKKWNPDTATFSAQDTTEPGHPVTRFAWAQKNSGTQAEVTAAASVREEGGSPRIDTLTLDGDEALFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G527</accession>
    <name>A0A401G527_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0101320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608172.1">
        <property type="nucleotide sequence ID" value="XM_027752371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G527"/>
    <dbReference type="GeneID" id="38774176"/>
    <dbReference type="InParanoid" id="A0A401G527"/>
    <dbReference type="OrthoDB" id="10683726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="410" mass="44419" checksum="77D7D4368DE8AF54" modified="2019-05-08" version="1">MIMNGIASPSSSHPLVAVALFLLSSTWFALSILMFAVDYLLGVLKLKAPVLSQEALRAQINKAATATHMQAYVEQRARTADECQHVSFSDAASPRESGPAPSRALSDRTLCAPSSPTRSVSSSTLVSRSSPSRLSPPLPRTTESKKAGVSCSRAESSPASSLSVSPRRPQMPLRLPTSVNMNMFRKSRRPPAADKQRAGSDPGSSTATQKLAEQAQRNTQNPPGESYRTTFVNPFRLKPLRSKTVSVLPTAKEHPEVNSEASIPASPPRRSSSKRLSLPAYLNINLNIQTSILQSPRPRTPREREGVPRTQPYGAPYFAAMPSPVEVKSRRSASCSSSPRKGSLDSGSRNYERLRAEELEEQRMRGTSLVSGFVPPVKQVNALGLSLGSGEEKRSTRHRPTKSDGVVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5K0</accession>
    <name>A0A401G5K0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0103160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608354.1">
        <property type="nucleotide sequence ID" value="XM_027752553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5K0"/>
    <dbReference type="STRING" id="139825.A0A401G5K0"/>
    <dbReference type="GeneID" id="38774358"/>
    <dbReference type="InParanoid" id="A0A401G5K0"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="27663" checksum="E8672BB791E144C3" modified="2019-05-08" version="1">MARKTELSCRPLRYREIARTVDVTERALRDTDPFFNYVFFPPPDAKYTRISKLGARFVLYIQYAYYVSQKEAITLDGGDGFITYDSAPNGLSLLRKIFQRMVQSIASVVIFLIITLAGTKEQHHRLKETRQQDEASKDTVNGGQLDDVFMIDTLAVTPDKQGLGYGSVLLEAVISQADAQSRRSYLYTRPQITPFYEKFGFVVVATYPVGENNPTWTRPPVQRVIMVREPTLKDAQGEEEQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5X0</accession>
    <name>A0A401G5X0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608472.1">
        <property type="nucleotide sequence ID" value="XM_027752671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5X0"/>
    <dbReference type="STRING" id="139825.A0A401G5X0"/>
    <dbReference type="GeneID" id="38774476"/>
    <dbReference type="InParanoid" id="A0A401G5X0"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="461" mass="50706" checksum="CA55A1CEB8DC8032" modified="2019-05-08" version="1">MPTTRRQAAALFQPEHDSATTAKSAAKGRKAAPRNVNVKASPDAVMGEKREAGQTEKEVQKAKEEPPAKKTKIEKTTEGKLKAEETDQTNAQMQDKKEQLGRKEKIKVDDSNTEPNLANNIETKKGDFGRRTYESGVIERGHIYFFYRPRVELEEAVSLDDVQRFYMLLIPRPPEFSTAPNEPSHASGEEAEDQEMKLLEPGADVVPAAEPTDQPKKNFRLLVIGKKSLPDPEVGGGKGGGRHQVFWATIVTVGDDLKELQEGLGASTYETKTRGTRHQGSARLAARGAYAIVNSEARTPSGRETHLGYYLSHPTSENFGKVQTELGIHTTSSFVLQVKNPLAPPVGPGRIGLPKGRRVDYPEDIMRQVFGKGGGRGREDFGLRFTSVEWKDMLDYEGVELLFIAARSGDVGLETSLGEGRGSALHEKEEDEAKGSIQDIFKELAMDAQKIPAEPLEGEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G674</accession>
    <name>A0A401G674_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0105350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608567.1">
        <property type="nucleotide sequence ID" value="XM_027752766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G674"/>
    <dbReference type="FunCoup" id="A0A401G674">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G674"/>
    <dbReference type="GeneID" id="38774571"/>
    <dbReference type="InParanoid" id="A0A401G674"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="447"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="580" mass="63806" checksum="261A06A6A0C3BED1" modified="2019-05-08" version="1">MTDSLIVTAEEINRLIHAYFVDSGFQHSAYVLSKEAQLEKSPCFRKHVPYGTLVDLLGKALQYVETEAHWRGDALTRNCTSGFSLIDKHICALDPTLPETVTLEEIAPPLGEEQLPPPPQTNGNAEPAVKRKASTPTPDDVPMEKRARTEPLEDNMDLDSIASSSDGRTTNAKASTSRAIASQRSNASRAPRLSVSSDDLADSQAATLLRGHKTEVFVCAWNPANKNLLASGSRDAIVHIWDLPLPKQDSVAHLHPPHTPVTFAYYPKPEQGDLTSLDWSPDGTLLAIGSYDAILRVCNASGEQYFANSQHEGPIFAVSFSKSGRWILTASLDGTACVWDVKGKKLHQQFKCHPVGCLDIDWITADTFATCGADGTIQIRTLSQTPQQVAASKSQLLGHENEVNQIRCNPSGTRLGSCSDDRTTRIWNIEDIAHGHQPNDVRDVMILTGHTDYVSTLAWCPVTRPGEHEIIATTSFDGTTRLWDSVTGDCLQVFQDHLDQVYTMAFSPDGRFLASAGNDGWLHIYDVKTRTRRWSWFAGTERPGIFEIDWQLAGKTSRLAMALQSQQVGVIDLTHVPCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6K9</accession>
    <name>A0A401G6K9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tip elongation aberrant protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0106880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608719.1">
        <property type="nucleotide sequence ID" value="XM_027752918.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6K9"/>
    <dbReference type="GeneID" id="38774723"/>
    <dbReference type="InParanoid" id="A0A401G6K9"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1137"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1266"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1416"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="827"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="946"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1300"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1174"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1442"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1470"/>
            <end position="1479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE77806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1479" mass="162945" checksum="AF7EB02AC70EA5D9" modified="2019-05-08" version="1">MSFFSRKKHAPQPATVPAIVQSPSAALAQIGASQQPQPAQPQKQLSKESSYESALNGRGSPAMGMNGLPPQVQQRPNRNGNVGAEVNGSPSLAGTQPQPSSSQLVQQQPLPPQQQQQQQQQQQQQQQRSAYPWSQRRLVLPPPVTIPKPGVAPPTNPSPSPFPRYGHALPATATATGELFLFGGLVREAVRNDLYLLSTRDLSATLLQTAGEVPSPRVGHASALVGSVLIVWGGDTKTNNKAKPGDKQDDGLYLLNLVSREWTRVAVYGPGPVGRYGHAVTMVGSKFYMFGGQVDGEFLNDLWAFDLNSLRTKAAWELVEPAEGSPRPAQRTGHVCVTYGDKIYLFGGTDCQYHYNDTWVFDTIVNTWSELTCIGYIPSPREGHAASLVDDVIYVYGGRGVDGKDLGDLGAFKISNQRWYMFQKMGPSPSARSGHAMASMGSRVFVLGGLGGESLNPAKPEDPTIIHVLDTKHIKYPDSNKPPPSGPPTNARKSSVGQPGTQQYGNTSPSGVINGVRSMSPETMSDAEDLRRAMSPTSLRSGKGPNGVAPQSLSSIAKGKAPMRPKREDEEDGESSPDASSSEPHARERAMSPEHGRAKSPTYNVGRAISPVSGEGHDTMQPMSMANVAMARNGMAARSPSPNVERSRVPLEAFYSGKPGSPTPNGYAHKPGSTGNLTADLIRDLKDKEADMEVLKKKQAWMRAALSEASRSGFVYTGTEEELASRVDSDDIDGRKVTEMVINFKQLKAKLQASVVEQAKEASARVVEAERLRTSAIQETAFYRAKVAALEAASTMEFEKLDRERVADLEGQLSTVMTEQAEKDRKIKELADSLAMQTKLLEQAEARADDASSRADVLAQSHDRTTEAHRTLQDKHSAMESTFHEQEERLLTQSSLLEQREADYLKAQSQIEELLLSRDQHVRALEQARTALQTSSARAEEVDAHNLHAQEQVTQLEADLAELRGELEARTTEVESARARIADVENSWAKSREEADAFRALTTGGLGDLLDSHRDLKRDEDRMSRGHEEKIAALQQEAASLHDMAKDASRRTDEIQSELAEERRKTRESESEALSLRCQVVGLRAQLSSTLADSGRLRRDLAAKEAEIQSRIREASSADVRWGTMRKFLAENGIVADGDDLRSNGASSSRLAQLERELSEQTRQNEIAERGLQSALQQKQDAESQVESLSAELDRLRNSRSPMRNGVDSESDARALEAEQKLEETEASYKARLQQLEEDYQLAVHYVKGTEKMMRKMKDELTKQKALNQSMQSEIERGSSTEPGSRRINGRNTPSSDDSHDALRTQLVDAQRQVQRLNSDNRELRLRIDTLERELEHMRDNVIASQQESDERLSRIEELESDVERLQNSLVIARGSHDETVLERLSNENTTLKRENEQLSHKIGLLLEADQPAFGHGRPISGISERPASTSSSENALEFEHLSTQLDDWQRQVASSMSTRRPLPDFDSPSGHERTRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6L8</accession>
    <name>A0A401G6L8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0106920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608723.1">
        <property type="nucleotide sequence ID" value="XM_027752922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6L8"/>
    <dbReference type="STRING" id="139825.A0A401G6L8"/>
    <dbReference type="GeneID" id="38774727"/>
    <dbReference type="InParanoid" id="A0A401G6L8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="117" mass="13423" checksum="44B63B1071144EFA" modified="2019-05-08" version="1">MYIMLAGGHPFDYDKMPGESEWYSYRQSEPLDDGSQISLSQNSVQTDCIVKKRIVHCEPEFPGMLWRSIPHAQALCSHLLVYDYLHRATVFHALQSDWFLSELAELEAAYNERIGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6N7</accession>
    <name>A0A401G6N7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0107120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608743.1">
        <property type="nucleotide sequence ID" value="XM_027752942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6N7"/>
    <dbReference type="FunCoup" id="A0A401G6N7">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6N7"/>
    <dbReference type="GeneID" id="38774747"/>
    <dbReference type="InParanoid" id="A0A401G6N7"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="533" mass="58372" checksum="0C3A38F927FF7C3F" modified="2019-05-08" version="1">MAESRLSHRKNEYKSKGGLKQEDLRRRREEQQVEIRKQKREENITKRRNFLPATAGDSDEEGATTTWESPLAEEMIAGVFSDDPDRQLDATTKFRKLLSKEKNPPIERVIACGVVPRFVQFLQGNNAMLQFEAAWALTNIASGTAEHTQVVITANAVPEFIKLLSSPVLDVREQAVWALGNIAGDSPACRDYVLQQGALRPLLNLLSENHKLSMLRNATWTLSNFCRGKSPQPDWELISPALTVLTKLIYSLDDEILIDACWAISYLSDGSNDKIQAVIESGVCRRLVDLLMHPSTSVQTPALRSVGNIVTGDDLQTQVVITSGALPALLSLLSSPKDGIRKEACWTISNITAGSPPQIQAVIDANIIPPLINILQNADFKTRKEACWAISNATSGGLQEPSQIRYLVSQGCIKPLCDLLTMMDNKIIQVALDGLDNILKVGELDKQATGPGAVNQYALYVEEAGGMVTIHNLQQHDNLEIYKKAFNIMDKYFPDDEEVDAGINTANVDATGAFAFDQGGAAPPSGGFNFGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6W5</accession>
    <name>A0A401G6W5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0107920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608823.1">
        <property type="nucleotide sequence ID" value="XM_027753022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6W5"/>
    <dbReference type="STRING" id="139825.A0A401G6W5"/>
    <dbReference type="GeneID" id="38774827"/>
    <dbReference type="InParanoid" id="A0A401G6W5"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="342" mass="37614" checksum="8C32505C5B1C2116" modified="2019-05-08" version="1">MSSKKLRVLLTNDDGPPGKDSPYIYGLYRHLTRDLCWDVRVVIPSTQKSWIGKAYQIHDIISGKYYYPRDPDGAGEVSQQPRPLKDDEVAEWILLDGTPATCANIALHNLYPEEIDLLISGPNHGRNSSAAFALSSGTIGAALSSSLSRLRSIALSYGIVLKPTPTTLIEPAHLLSSKIVRHLWENWGEDEGGLRNGEVDLYNVNIPLINDLLTEEGLPICWTHMWRNSYGSLFKVHTPREAASPMSAAGPDALDGPNDVRSSLGEKETPLKDLGNLLFKFAPDMQDLINPALSTVPVGSDGWAILKGWVSVTPIRASFAEPGEQRLQSIADVEQQVWKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6W7</accession>
    <name>A0A401G6W7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0107860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608817.1">
        <property type="nucleotide sequence ID" value="XM_027753016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6W7"/>
    <dbReference type="STRING" id="139825.A0A401G6W7"/>
    <dbReference type="GeneID" id="38774821"/>
    <dbReference type="InParanoid" id="A0A401G6W7"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="608"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="861"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="513"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1096"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1139" mass="125678" checksum="B8CFBDBC6F312D4A" modified="2019-05-08" version="1">MTAKSHQIDLPEIPSLPPIRMPDASHFSDTSTPSLYSSRVPIPASRSPSSPDTFQTTQESPSVNANGNPTTNASVSFLTLTPPSSLSLPSTLRKSISVDSFIKHRQPSSPTPRSGPASAVTSHLLPPQETTPRSSTSTLPSEVPLSTFRAPLRGRDGRVSPPQLLHGTSTNVEDREVSSFFDESDVEQSESVGQRPRKAKAAMRHVVLPPGELVLPSRLQTTNSFPNIDASQPPAPIVPARSSSLSHKMIKQRALMHVNTQIPSNIEPWQPPPVTIAVVGAARCGKSTVIRKGLKAYGLSEPETITLSDTPEFGVDAFIYTSRSGRISVSQDTPERVFKVLEVDTASLSLNKKGNVWPDIRPKLDGILVCYDAAREESFLPVETVLREFSGLKLPTVVLACKSDLDAVVDPQHALEVIQSYDVGLVEVTNSHSFGKGKMRDAFDWIFKAIFHALDNRGGMRTERDRYRNPASPAVLENPSAGDISRASSATPTASGVTLQSAQLHSMSISQPYAKAPSSVSPHATGQTPIPAGLFHIPSPTSSGPHTPSTPTSPTRARSTSDIFSEHEKAKRVRSKGSLNVLPSASGSEPQTGFEDINESMRDVSIRESRAPPWMTLEELLNKLLFMAVSDDDPVFISHFLLTYRRFASPRSILLAMQKRMRALDQPSGDPMFACFAQMRICLLLDNWIKIFPNDFAVPGAHSALAALVKSILAKTYLLHYGSDFQPFVDSVPNINDGDKSWALRVDEESDVFSVLSDEESFSTLDTSMLDTDSHLSSSLSQFPTDDDGLLVGAVPPTSHGPTAGPSRERKASLPLTAKALIGSSMTSSTGIGHFEGGAYIPAKQQLKQLIAMAQELNAIDPQEIAQEISRIESQFFLQIEPRHWLQHVLVQGRKDPESDTIAKYNHVSNHIATWVVSFILCHDKLKHRARQIEKFVDIANRLRAMHNYSALRAIIAGINSATYEGDPALEMFRSRSPELWKSFQSFDQLLQSVRSHQKYRMALRNTDGPCIPALEIHLSDLIRAHEGNSDYHDDDPNKIHWAKFNMMARFIDAITHCQRGCHESGEYEYPPRENICKLLLFLNEDLLMDTEMQRSRIAPPDSDGEEGYRSATPRTYSRDTPHHPKEPQILRKIFFWQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G728</accession>
    <name>A0A401G728_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-insensitive transcription protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0108580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608889.1">
        <property type="nucleotide sequence ID" value="XM_027753088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G728"/>
    <dbReference type="FunCoup" id="A0A401G728">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G728"/>
    <dbReference type="GeneID" id="38774893"/>
    <dbReference type="InParanoid" id="A0A401G728"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="102"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="199" mass="21666" checksum="797B0BE71A3C0C6B" modified="2019-05-08" version="1">MASLRHEFYETDERLTLEVFDKGADPAAVSVTFQPRSLAYTHGEKTLVLEPLKGQIDPEKSTYTVGKFKVEIRLAKMAQGRWGALVGDSPDPLTTIPAASAPAPTPRQPQKNWEGITAAILDEDKDGGPSEDPNAGGDTAVNGFFQKLYADADEDTRRAMLKSYQESGGTTLSTNWDEVGKAPVEVKPPEGSEWKKWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G763</accession>
    <name>A0A401G763_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0108870</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608918.1">
        <property type="nucleotide sequence ID" value="XM_027753117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G763"/>
    <dbReference type="FunCoup" id="A0A401G763">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G763"/>
    <dbReference type="GeneID" id="38774922"/>
    <dbReference type="InParanoid" id="A0A401G763"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="215"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE78005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="312" mass="33770" checksum="275252ADB084F07F" modified="2019-05-08" version="1">MAEQKKGKTPKEFFIDFMMGGVSAAVAKTSAAPIERIKLLVQNQDEMIKQGRLSEPYKGVIDCFSRTYRDEGLVSLWRGNTANVIRYFPTQALNFAFKDYFKSLFGFKKQEGYWKWFAGNVASGAAAGASSLLFVYSLDYARTRLANDAKSAKGGGARQFNGLVDVYKKTLASDGIAGLYRGFVPSVVGIVVYRGLYFGVYDSLKPVVLIGALEGSFLASFMLGWGVTVGAGLASYPLDTIRRRMMMTSGAKVHYKSMFDAGAQIVAKEGTKSLFKGAGANILRGVAGAGVLSLYDKFQEVIFGKVYSGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7C1</accession>
    <name>A0A401G7C1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0109440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608975.1">
        <property type="nucleotide sequence ID" value="XM_027753174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7C1"/>
    <dbReference type="GeneID" id="38774979"/>
    <dbReference type="InParanoid" id="A0A401G7C1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20276" checksum="E5EE4FBF6B61FD46" modified="2019-05-08" version="1">MDASIILRKYILAEALLHIEIFTEPFDPILWKAWVIRMHVLLVLMVQAQSEAASVGIILPRPRNIPVLAQVEIHLVTARTIEGGCQMIPQIADHLPDIIPRSLTARVLYDDPTVHKNFGLGHPPDGLPDIGTLSLRVETLRNAACELYDVMRGITSRHDVTHQKCLACEHVTTGEALDEEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7L0</accession>
    <name>A0A401G7L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0110340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609064.1">
        <property type="nucleotide sequence ID" value="XM_027753263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7L0"/>
    <dbReference type="STRING" id="139825.A0A401G7L0"/>
    <dbReference type="GeneID" id="38775068"/>
    <dbReference type="InParanoid" id="A0A401G7L0"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47251:SF1">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="55314" checksum="3C8B7E92C2526333" modified="2019-05-08" version="1">MSAESIARWNAIPLTRPDTENDVHTSLKRARPDNNTEDNDDDSEDDVSLVSRSPSPIPPDAMDVDKYDEYVRRTVEHEVITVNTKIKNSNRGFLMLANMGWAEGQSIGLSGDGRVDPVPFYVKNDLTGLGKANQDVRMIESTVAQRRELDSERQTKETEEQKKAREDTVAKRAAVQSQISTTLRAFHCELCDKQFQNVAQYDEHTNSYAHHHKARFRDMQATQRANKNTKEEVDKRKEKEKKREEKELRKIAKAAGVKMTKPPVSLVLPVARPMAAEEEEPSESKKTGWASIASSSQPADTPALTASSGFTKSGWAAVDPSVFTGRGAAVTPQESQTISGVTYPVTSTSSPMPTQRPSTGHTPTFLTGGWTSLDTGSSMTVPPPPQGHYLPPPPPRTISPPLPPTPNQQPPPPTAGPPPSLPPPAYPPLSAPPRRGWASASAPPSSDQPSRAGWQKVSTSGAVGPPPLLNVASRPLPPEVSRPPAPTRQETSRSGWQQFRAGAPGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7N0</accession>
    <name>A0A401G7N0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0110550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609085.1">
        <property type="nucleotide sequence ID" value="XM_027753284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7N0"/>
    <dbReference type="STRING" id="139825.A0A401G7N0"/>
    <dbReference type="GeneID" id="38775089"/>
    <dbReference type="InParanoid" id="A0A401G7N0"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="836" mass="91209" checksum="77434D2704FADA12" modified="2019-05-08" version="1">MLRSLRPSPRCSTDLLRRPDRVIPRLAPVRYGSTTPTPDPATLPDIEPARLEIERTGEPKKRPEPSEIVFGHNFTDHMLVVPWNATTGWDAPKIKPYGPLLLEPSCSVFHYAQELFEGLKAYRQESGKITLFRPDMNFKRMNTSASRIALPNFKPEAMLELLKKLIQEDKDWVPGLPGYSLYIRPTMIGTQAALGIAPAKEALLYVICCPVGPYYPKGFKPVALYGTTKYIRAAPGGIGGYKLGANYAPGLVAQREIEKQGYIQNLWLHGPDHLITEVGTMNAFVVFKRPDGATELVTPPLDGMILPGVTRDSVLSLARWHASGQAKIADLPDDLVVSERSVSMKEVKEAEKTGTLVEFFGTGTAAVISPVDRIGYLGEDIHIPTGPDGMGPVSRPIWKQLTSIQTGKIPHEWSVVSVDTSQLQDLDDCDRARGIVRSWARLVGFSNIKFPVLLNVACMALRPSLSVRPCRAKWRTGKARYIYAPCVSTRNYAVVGSTTYVGEPPSPPSPPPTEQPPSSSFKPPDASTAFDARVLYELRRHATPPGSEDRLHDLPELILQYLDRSERVLDVGLPYESRPSADRRTPFDSNASEENHTVAMVVHAAQSGEEHKITHCSGFAINAPGMSEGEAVFVTCAHTLEEIRHSPVLNAIPKPHVSGSLLVSGDASSPTFSPVSAVLSALHRSDLVLLSATAPANLRTLPVSPYPAHPGTPIRAHFVCEAPPTSTSDADADGWTPWVGGTWSKWVRGTVVEYRDSAGREAKPGSYDALAHLHFDPPPTPGSSGGPIVDEESGAVIGVMLGTQLQNRVEGVRGWGVPAEMIFEMFRLPGLKLKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G828</accession>
    <name>A0A401G828_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0111820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609211.1">
        <property type="nucleotide sequence ID" value="XM_027753410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G828"/>
    <dbReference type="STRING" id="139825.A0A401G828"/>
    <dbReference type="GeneID" id="38775215"/>
    <dbReference type="InParanoid" id="A0A401G828"/>
    <dbReference type="OrthoDB" id="3258416at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="68699" checksum="3D31A9D03E6A1144" modified="2019-05-08" version="1">MPVPYDRKTLENMKRSDLQKICKDHGIKANLKSEALVDLLLDTQQPPKPVNRAPEPKRASSLRVVSRSTTGSRMRSGGTVIVHDTDEEEDQLAGSNEEQEPAPLEASAVPTSRTRKAKETQYRLGVGRPVTAGGTGPRAITKSVSVSREKRIKGSRSVKPSEEAIREEDEELDDAAEAGPSNSTITGSSMQTATVDVPPVSEGVSEQVKSHVSQVIHPLQDHIRTLQADLQQATIQSAEVPAMKAKVDALIAEVESLRAQVTLTNELRAEVAMLRGTMSAMNISRENDAYSRTQSEKSAGKARATDGGSGLSPDSKTIQPSSSTLGKRQRDSPDSNIVDAEQPHAYSEKELGKKGLRPTKKRVKLSRDDQATSSLQHHTPEREDIGDIDEDGVIITPAPPAPPFTVFSGPEEPPEMYIDPPLPDTRLSDLFVIPSSGSTPPSGNGTGPVTSTANGTENTQQSSTFSFSFTNPAFHPVTSTPAAPYGMTSPSFYAEPPISPTPGAADPSGGYIERAGGRRERNDLFNPHGGPRRPRSAAGPSRPRSRQSRTTTPAVENGCVEPSALLRTPTTLSTVPEMDSMTTPPASSNEVGVGLGMSGIPETPALPMKRTMYGTELEGDTRFGDFGVEGVATGFWTGTAPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G849</accession>
    <name>A0A401G849_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1764-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0112030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609231.1">
        <property type="nucleotide sequence ID" value="XM_027753430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G849"/>
    <dbReference type="GeneID" id="38775235"/>
    <dbReference type="InParanoid" id="A0A401G849"/>
    <dbReference type="OrthoDB" id="20835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066:SF1">
        <property type="entry name" value="DUF1764 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34066">
        <property type="entry name" value="GROWTH FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16774" checksum="09973C20B2CA266C" modified="2019-05-08" version="1">MPASEIDEIFASKGKSSAPKPSSSAPSTDTPPKKTKKSGKRKREAKGETEVRDESESKKSTKRRVPETVLDPSARIAAPATSNKSTKLQNIASDSAAKKKSKKAIEVEDRFKDSRGTGSRRTTEEGFAIYKESDLGITEQGGNTPLCPFDCQCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8K9</accession>
    <name>A0A401G8K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein MGR2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0113620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609386.1">
        <property type="nucleotide sequence ID" value="XM_027753585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8K9"/>
    <dbReference type="FunCoup" id="A0A401G8K9">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8K9"/>
    <dbReference type="GeneID" id="38775390"/>
    <dbReference type="InParanoid" id="A0A401G8K9"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13304" checksum="94FB76C7C906228F" modified="2019-05-08" version="1">MAQPQRNYAGPTVWQKCTMGAMMGAGVGLTIGFIFGSYSIFRGGAGPRGVLPTLSQYMLSSAATFSFFLAIGSVIRNDTALPPHLEAARLQFTSPIVRSRNEGIAMMKRRWDMEKARERQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9R9</accession>
    <name>A0A401G9R9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0201050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609821.1">
        <property type="nucleotide sequence ID" value="XM_027754020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9R9"/>
    <dbReference type="STRING" id="139825.A0A401G9R9"/>
    <dbReference type="GeneID" id="38775825"/>
    <dbReference type="InParanoid" id="A0A401G9R9"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF9">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="712"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1138" mass="126755" checksum="C7D7154F17C3594E" modified="2019-05-08" version="1">MRAYLHDLFDILPFTDIENIQEVLNLEHRPDSVFSLLTEKDLSALSSLSASPDLPPRSRSISSCSFNSGLQIIITMSSSNIATVAQSSSKHPPVLTSGKITPAVAHAWENTCLQYFKQNDTPADKRVAKVTSGFQDTIVSDWYYNDSDTFDALPWKDFLATFRSRFLPKGWESTILTQLLRSRQKDDEPFEDWVLSLEKMNTILRGSTSHLDDTHLHAQIAASICEDLRFASDDDDVCNIISFKDWKDKLAQMDTICLRERARILHITGASARSKPLGLPIKAMSGKSNTARLPSLTDSELKLLRDNDGCFKCRKFFIDKKLRGKQNCPESFPDPTTYCTLMQADVDKVKRGVGKENIKPHLTVSVVVDGSDDAVYSISAIYLNAPPLAATSGILGTGSDSDNEYVSPALAPFTVPHIPWSTIVHGPSSDSQPLPMLINSGSPAVLIRLELISHLGLRRRKLPQPFPLGDVWGTESKDSAEWVKLRVSLPDSSWSSIVCRAIVVQSCCYPVIVGRPFLKSNHLVVDHSCNMVIDKRSRHDICATLMPPPPTSTPPTPTTLLRISPDPHLFRELSERTAAHHVECDEHTTNTAAATIHTLRKCTEELAYQEKLRAANLEVKQEFVDLFPDDIPHLDDLPTDVYHRFMLKDPHMADPQKVEKILNWSVPHNSSQVRAFLGLVCYIAPFLPKLADHMHILNALTTKEAELNFPQWTLAHQRAFDDIKSLICSHKVLTVIDHDNMGNNHIFVSCDASDFRTGALLSYGKSLETAQPIAFESCTLKGAELNYSIHEKELLPARLVGSSRHVDSKCPKLVVDSPEKPARKEYQYVLKNPPCARTPSPPPADHLEHTPNIENSVEDTYSVPLEPDITSSAPATAILVPASPPNPSLSDSIPDPASASPLSISLSVSPHAPNFPIIPLPIITMSSSTAKGLSGMPAPGSSKVPSFHGESSELLEFFEFFEDLTNDCKLSAPEKCKSLVHYVDKTTKHFWISLASYESQDFETLKKNILAQYPGADKGIRYTLRELEQLVVEQAGSEIQTETELLTYYRLFCPISQWLVHNSHITDCERNSYFWQGLPRDTRRAIDRRLELTIPDFSRAAPPDVEKVVAAGRFVFSDEAFDSEYNDPISMRLRSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9W7</accession>
    <name>A0A401G9W7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0201440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609860.1">
        <property type="nucleotide sequence ID" value="XM_027754059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9W7"/>
    <dbReference type="STRING" id="139825.A0A401G9W7"/>
    <dbReference type="GeneID" id="38775864"/>
    <dbReference type="InParanoid" id="A0A401G9W7"/>
    <dbReference type="OrthoDB" id="2798901at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="43263" checksum="362120D22DC8C2DF" modified="2019-05-08" version="1">MLHDLPLELTDRIIDYLSDDHASLRSCSLTSHAWLPRSRFHLFSNMHVEENERLGSLVDVSYSNGAPPLDLVRSLTFKGIYWNPPWTGRLADIFGNSSSSLQAFIAQQTESRYAGILVSTLRQFRNVTRLDLSGCTFRNLEMFRDIISAFPLLRRLCLQCVLMWDRVSPSDDEVESDYPLSRPWTSCPPLTHISLVSRMRSMWSVYQYIVSTTSPQSVRSLELAVPRSGLDYAGSSIEVVAPHLERLKVEPEEEFILAEWRLLNLNNCSALRTFSMANTGGVPLAEILRFLSPCCRVRVLYLRLHAIEERWEDLREVVTSEQFSELREVTMTLGDVYESPGSSIQCVNEFAEFLERRGVRTAVVGRESRFLRSSNTLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAP2</accession>
    <name>A0A401GAP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0204100</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610126.1">
        <property type="nucleotide sequence ID" value="XM_027754325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAP2"/>
    <dbReference type="FunCoup" id="A0A401GAP2">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAP2"/>
    <dbReference type="GeneID" id="38776130"/>
    <dbReference type="InParanoid" id="A0A401GAP2"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000150">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="17">
        <location>
            <begin position="113"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE79213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="432" mass="48968" checksum="DFA4F712EE1C1B95" modified="2019-05-08" version="1">MASTVSDSIRILDKSGKEITTVGFERFGFDCEVPLAVLRSLYLRSHYVLTAPSTAPESGKTKEDEVHAKVSGDLEAYQSKSIFHPDIQSISYTTLTRFPPVKLLAPSKRKRILVTGGAGFVGSHLVDRLMILGHEVTVLDNFFTGSKTSVSHWVGHPNFELVRHDVVEPFMIECDQIYHLACPASPPHYQFNAVKTVKTSFMGTLNMLGLAKRTKARFLITSTSEVYGDPEVHPQPEDYWGHVNPIGPRACYDEGKRVAETLTYGYHRQDGVDVRVARIFNTYGPRMNPFDGRVVSNFIVQALRGEDMTVYGDGKQTRSFQYIHDLIDGLIALMNSEETRPVNIGNQDEFTIGEFAELVREIVEKVQREDGELPPRRVQIVYKPIPTDDPQKRRPDTTRARQVLQWQPRWTVRMGLEEMVRYYKAKMVEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC83</accession>
    <name>A0A401GC83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0209710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610683.1">
        <property type="nucleotide sequence ID" value="XM_027754882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC83"/>
    <dbReference type="FunCoup" id="A0A401GC83">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC83"/>
    <dbReference type="GeneID" id="38776687"/>
    <dbReference type="InParanoid" id="A0A401GC83"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="21112" checksum="5FBCE6575D04FF43" modified="2019-05-08" version="1">MPSDILRKRKIAVLGSRSVGKSSLVIQFIESHFVESYYPTIETTHTKSINYRGVEYDCDIIDTAGQDEYTILNPKHAIGIHGYVLVYSVASRKSFNMVNLVYDKIVDFCGLNTIPCVIVGAKTDLPKASRQVEESEGQRLADEHHAAFVETSAKNNQNVAEVFQLCLGEIERQSPNHHDEPPASKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD05</accession>
    <name>A0A401GD05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0212690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610979.1">
        <property type="nucleotide sequence ID" value="XM_027755178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD05"/>
    <dbReference type="GeneID" id="38776983"/>
    <dbReference type="InParanoid" id="A0A401GD05"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="11257" checksum="7979C5D12C770C14" modified="2019-05-08" version="1">MTETWGPSKAQLTAAAAYEVTGSWDDEGDGIRSVNAALDANDEDEVSFDEATDPEDDGELLDAAEGAALTDAYHPSAVDFDSDSLFDDGVMRMVSQSSRKRVLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD94</accession>
    <name>A0A401GD94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase orsE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0213330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611043.1">
        <property type="nucleotide sequence ID" value="XM_027755242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD94"/>
    <dbReference type="STRING" id="139825.A0A401GD94"/>
    <dbReference type="GeneID" id="38777047"/>
    <dbReference type="InParanoid" id="A0A401GD94"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="347" mass="36063" checksum="AFC673C12055788E" modified="2019-05-08" version="1">MSTPNAASYLTAPGGTFTVKDAPYSKPGPGEIVIKNAAVAVNPMDWKIQTFGAILPFPKQYPAILGADVAGEVYEVGEDVTRFKKGDRVIGKPSWFLTARPQDGGFQHYTVCISSVVSPLPASIPFKSGCVLPLALCTAAMGLYPSTRLALPLPQPTKPKSINKVLLIWGGSSSTGSAAIQLAVASGVTVIATASSKNHGFVKGLGASAVLDYQDDKIIENLVEMIKGAGGEFAGALDAIAEEQTWRACAEVVKALGGGKVVSNLPTTFVDVPEGVEVLPVNNTSAIVQHKEIVEGIWTQFVPEALKAGTLKAVPEPVVVGTGLEKIGEGVELCKKGVSAGKVVVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDQ4</accession>
    <name>A0A401GDQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611219.1">
        <property type="nucleotide sequence ID" value="XM_027755418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDQ4"/>
    <dbReference type="GeneID" id="38777223"/>
    <dbReference type="InParanoid" id="A0A401GDQ4"/>
    <dbReference type="OrthoDB" id="2742726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="966" mass="107843" checksum="5394CD0A8BF4F0DC" modified="2019-05-08" version="1">MHSHPSFLEFLIATRCTLNKLRYREEHKELQRRATQAAKGQINAVLLGGSCKKLYHSSYDSFGPPLALASEHDPTNFITGPDEIKSHTRAYFTTLFAQQDRPPMPKPWLTTPSIVQIRTQTSHDPFHWPQPMSLDDLRLLLRHGKPRPAPGPDGWEKWWVKALHDFSLQLVLDLLNFEISHSHFPDTVKPCTLSTIYKRGPRTMLSNYREVCCSNLLLNMPFTWLNLLLGPYLAKHHILPPGQVATQPGIQGRDLTSFLAQLEAWLNRMHTPLYILCRDQQKGFDHLEPQGFYDAVTAYGLPITLIQFDISAQSDVPYQVKTAHGFTEPLIISDVTKQGGPISPMKSTLMTSLGNHWLKDIFAQHGDGLLIASLQQLAHRPYLPDDRLTLPVNMVEAMDDSAIITTTQGSLERSCLFMERFQAAYGWFTNWVKSLLILLNILNAPPLMRMPSISPDDPASSTLIWHDVQVTTSHIEFLRVSINNPQHQFEKLRDIILSFDLPNLSLRLPLTVLRRIFAQCLISRLRPHLAFQPISRSHAMELDHLLALRVHQYFSFPFRFNAILLSLPIQHYVYGFDFPSINRLNDCAVVSGLWRDLNHHNPAFHDMAHITLADWTCSINHCVFPLHPISQESYACQTHHLPPSWITAHTVLSTLRLSIRQTDLSYLFSGDVSLCHLLRSLPPLPDHPMPSPQMITNLERAGFTHLHHLVTWFPSNDPLAPPSWSLHPTASVSNMLRFTAAASDWPAVSGWLQSLSLPYLVAGQGSSGAVSRSTRDSNGSTGDLSVTRDWTLALPRDLRRTLAEQVILTLLHSSHLPLFPSTSPTCASDGSMTPAAALFRQFRSVTFAVSTPTASLACSLSSFGLSASILHAEVYGIVVSSLSACSAPSPSPPSSLLPLYTDHLNSVRLINDSISTSSPPPLISGPGSPRVLSIGGYNSSSPLPLITLFKSTTHLHTPPPTLFHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFA8</accession>
    <name>A0A401GFA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0305720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611765.1">
        <property type="nucleotide sequence ID" value="XM_027755964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFA8"/>
    <dbReference type="FunCoup" id="A0A401GFA8">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFA8"/>
    <dbReference type="GeneID" id="38777769"/>
    <dbReference type="InParanoid" id="A0A401GFA8"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="89"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="347"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE80852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="408" mass="46096" checksum="449A2770B02C3EB1" modified="2019-05-08" version="1">MFKKVADKLGHLGPNKQSMHASTSSSVSSMPSVSTMSHEYRSSISTGMTSVSGRSKRPEKIEIEENIGMVGHPLLPPRRPKGSYRLSDFIIQRTLGTGSFGRVHLVRSKHNLRFYAIKVLSKERIVRMKQISHTRNEQMMLQAVQHPFIVNLWGTFQDSANLYMVMDFVPGGELFTLLRRSNRFPDPVAKFYSAEVALALNYLHSLDIIYRDLKPENILLNFDGHVKIADFGFAKYCNTTVWTLCGTPDYLAPEIIGNARYNKSVDWYALGVLIFEMLAGVPPYHEPDTSAVVLYEKITQGPSCIKWPAFHPNATDIILKFMESDPSKRFGNLRHGAGDVFAHPWFREVDWDKLRNREITAPYLPKISGDGDASAFETYPEGNTAAQYGAFTEDLYGDLFPEFEYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFD7</accession>
    <name>A0A401GFD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0306020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611795.1">
        <property type="nucleotide sequence ID" value="XM_027755994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFD7"/>
    <dbReference type="STRING" id="139825.A0A401GFD7"/>
    <dbReference type="GeneID" id="38777799"/>
    <dbReference type="InParanoid" id="A0A401GFD7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="619" mass="71074" checksum="F8BC5ECEA9190D7B" modified="2019-05-08" version="1">MNDSNWKKTTRMVPTLMTKWKHVLLGFPRSKESFEALSASTDEEVLEAWQKEYDDAMEARQNDPKIMDTFNVQLRKAPGKDLTQLRLAGEESAKGLEKGTAGWLSTGLKIQEAQLKLANDIRKAGQNPSVAEDLKTLERRQRLEVSILTFQRCSEKFMGRLEDVPTMEDRDDGALWDSLDENPFQIHPEDAEYGEDAIPPEQASLNLPSQIGFVAAVTNRLQTLAAQELELRKGLMNDILHELRMALGLKSYLYRKRVRPANSVGTMTRAQAEVHAADQTVLACARLYSANRRAIMHLGATDEDLALYRPLDKKDLHVKTAVIEASTSGLRNVNLAWFWTMDVAGDRGSSEWMDEFYRVNWLRARARYERWREERVLVHSEMAWTIATFKRNAERWAHWLEVTDPSWWGHVCYAARQSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVRWEEGLRREMFAVRGICGDLALAGHADHIDHGGVIASVLTVCTFNREVLRPISIDVKAIPHPTTLVPRPKNLLEDSPDYWWKWDHQVGPAGSPIEAWWYKLGDPWEKVYTVSESTLVQLEQLHVRITNLTSWLHERTDQNLDVVLEELQEATRQLRELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH02</accession>
    <name>A0A401GH02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612361.1">
        <property type="nucleotide sequence ID" value="XM_027756560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH02"/>
    <dbReference type="GeneID" id="38778365"/>
    <dbReference type="InParanoid" id="A0A401GH02"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="11713" checksum="E25F55C2183CE24F" modified="2019-05-08" version="1">MGVLPHLTLAPFGLDLHCSSSAAAASTIRQGPARVGRSDQSEQFSMNTLQGAKTDTTFPLPSISALMPIADPSGLHVVKTTTTDSRCPPENNTTDGCTFVITESSVYNSEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHJ2</accession>
    <name>A0A401GHJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0400100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612552.1">
        <property type="nucleotide sequence ID" value="XM_027756751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHJ2"/>
    <dbReference type="STRING" id="139825.A0A401GHJ2"/>
    <dbReference type="GeneID" id="38778556"/>
    <dbReference type="InParanoid" id="A0A401GHJ2"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="11541" checksum="17D216DF29D635B4" modified="2019-05-08" version="1">MASHIGRIARLTLFSGPNCSLCDVAKAELAKVRQQRPFELETINIQDKGQERWKRKYVYWIPALHLDGKEVAKGRWDAQTVIQALDAWKQSQCGEEDTKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHP0</accession>
    <name>A0A401GHP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0400810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612623.1">
        <property type="nucleotide sequence ID" value="XM_027756822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHP0"/>
    <dbReference type="STRING" id="139825.A0A401GHP0"/>
    <dbReference type="GeneID" id="38778627"/>
    <dbReference type="InParanoid" id="A0A401GHP0"/>
    <dbReference type="OrthoDB" id="3210731at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="955"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1143" mass="122773" checksum="6D97647D14F74558" modified="2019-05-08" version="1">MSVSSRHVRTLSPPLSTNGHFNAFTTGNQRLNVVTRLAVEGKSKKGWDGASIKVYLKISLPGESITPGATIALFPEENLKILDSQVHPLDNNSVPYNFSSTTCPLIHKAARALNLPARSPHSYVSVVDSASSSSGAPLEDKYTGHVLVSGYHVSYILPKEFPRRESDSRTRRGTIVAQFMAAIDIWVPFLTRPPFAPFLLSIPVPRCLSNHIKLSIFSPGPASMASSMASLSSVEEDMGPLELASEPHVTRSQSARISRSQSYTHFADDESSDASSSAGFAEGCGIQGTFPSTDRIRVRWAAPAKAGQVPETEDGRRRVGIKDVKGDMTCEMVGKGKGRDRGVEGLLMKLEYNATCKGVWFPGVATLVGMDVGLEAGDCDVSWALGTDPKWTVTGGPGFTGFAVGGPTQTPSPPPSMVRPPIYVLPSSPDGGALHGTSSPPSRQNSAASTTSTSSASLLRAPLPNQNTGDYSFESSPVSTPTGTISSLPSVGLPSSPERQRRSRASSVNGPYTDTDTDFEPDVRPPDAPITVHVNMNELLPPSKAPFTFRISGTVLVTPRHPLITPERRKSPPNKSKHPSSDDVVVGPTVVPMFHLFYKDREKTSTIVRNGADGADLEVLAAAGDLRDGKTLKMTLKEGDHVACGADGAHVALRTFPLSASPVPSGSRELSMESEDTPQTRTRKPNGTRSYLAASSTRYASMMSSTKPRRDGPLMIPSVTATVTPLLSEGTAFHNGYAVQISLPAPSDTDSEWLEFGLARPTADPSSSSNSDATTSNGFSPPRVDIASASVEGVPVRFQTSAVSKPNGSLGLSLAFEETSAKEWITWVGVHVGQAGGGKVEVIYLVKGLKEQIAQGDKSQPTKGKQKADNAIPFDILLPSFALPVGRLEVNVQVQAGYEVSAMRTNLIHQQSNSPALRLLQFSLDEFYYPRLYMAIAPQQTSRKLSMPSPTFRRLGILLACLLPIALISYLLMDLRLKTAELHEMRASLTNRSPEFTADYPHNEPETITVTTTILTEKWWFSASTGTLPLDSPTPPFSTSQARTQSPSQYPSQLSTDTLMPTMTGIPVLTPSTSASSVSHGESHSLLSLSDESFAWTLRFELPVLKLPEVPETARATMDALINGLGAVWHIFRKVLHYPLDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHY6</accession>
    <name>A0A401GHY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposon Ty5-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0401700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612710.1">
        <property type="nucleotide sequence ID" value="XM_027756909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHY6"/>
    <dbReference type="STRING" id="139825.A0A401GHY6"/>
    <dbReference type="GeneID" id="38778714"/>
    <dbReference type="InParanoid" id="A0A401GHY6"/>
    <dbReference type="OrthoDB" id="2796020at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="127"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="466" mass="52986" checksum="12FAC2425D0506BA" modified="2019-05-08" version="1">MTADVRREGELGTSAPQSPAKNPRKCRRDDDPDQRKESETDAPSQPRRTRRKTVRHDYRLMHDPEADEDLDNEPDKSNAKLVYIVMSAHGNADADEPKTLSDAKRSLEWPKWEQAVQTELNQLQGMETWELVEPPEDRKPVGNKWVLVKKTNKEGEIIKYKARLVAKGYSQIPGMDYTETFAPVVRLETIQAILGLAAILDWEIGQMDVKGAYLNRTLKEEVYMRQPEGYSDGTYRICKLKKTLYGLKQSGQEWNIVLNRKLLNAGFKRLFSDPCAYIQIKGDKIEIITVWVDDLLIFTNDCALMDQLKSELQNMFEVTDLGEPWKIVGIEIERDRSKRTIKISQTKYIESILHKNGLTNANTVGMPLDPNTVLEKEEPKTDDECDRDNGYASLVGSLMYAAIATRPDIAHAVQRLSSFTANPGMAHWTAAKRVLRYLSGTRELGIIYGPIADVKPEDQAKFVNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI36</accession>
    <name>A0A401GI36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0401910</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612731.1">
        <property type="nucleotide sequence ID" value="XM_027756930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI36"/>
    <dbReference type="FunCoup" id="A0A401GI36">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI36"/>
    <dbReference type="GeneID" id="38778735"/>
    <dbReference type="InParanoid" id="A0A401GI36"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE81818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="396" mass="45129" checksum="39349AAFB6F28487" modified="2019-05-08" version="1">MSTEQLQDVQEAEIESNWDQIVDNFDNMDLKPELLRGIYAYGFERPSAIQQRAIVPVIKGHDVIAQAQSGTGKTATFSIAILQKLDPAIKGTQALIIAPTRELAQQIQKVVVALGDYMNIECHACVGGTNVREDMAKLQEGVQIVVGTPGRVFDMINRRALRTDTIKMFCLDEADEMLSRGFKDQIYEVFQLLPQDTQVVLLSATMPADVLEVTKKFMREPIRILVKRDELTLEGIKQFYIAVEKEEWKLDTLCDLYETVTITQAVIFCNTRRKVDWLTEKMHSREFTVSAMHGDMEQKQREVLMKEFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRESYIHRIGRGGRFGRKGVAINFVTTEDVRMLRDIEQFYNTQIDEMPLNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIE7</accession>
    <name>A0A401GIE7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0402770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612816.1">
        <property type="nucleotide sequence ID" value="XM_027757015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIE7"/>
    <dbReference type="STRING" id="139825.A0A401GIE7"/>
    <dbReference type="GeneID" id="38778820"/>
    <dbReference type="InParanoid" id="A0A401GIE7"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="415" mass="45447" checksum="0614076DA088467B" modified="2019-05-08" version="1">MFTHKCVRQHSLLFSLYRSGTRRQSTAAEPLPAGGHLPSIATSSFLRSGRDSAIRTPGIQWADEDASGPTRDIVAGRETRKMNLYQAVRDGLSVALMKDDTAVVFGEDVAFGGVFRCTMGLAEEFGRERVFNTPLTEQGIAGFGIGLAAMGHTAIAEIQFADYIFPAFDQIVNEAAKFRFRSNGQFQAGGLTIRCPSMAVGHGGHYHSQSPEGFFMGAAGIKVVIPRSPIQAKGLLLGSIRDPNPVIFMEPKILYRSTVEQVPIDDYQLPIGRAETLVSGSDLTLLSWGTPLYHCETALHMLATPPESLTPFVPASLRSTKVELIDLRTILPWDVETITESVKRTGRLVIVHEAGRTGGVGTEISSEIQKRCFLKLNAPVKLVTGWDTPVPMQYEKFYMPDSIRILDAIVETLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIF5</accession>
    <name>A0A401GIF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0403420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612879.1">
        <property type="nucleotide sequence ID" value="XM_027757078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIF5"/>
    <dbReference type="STRING" id="139825.A0A401GIF5"/>
    <dbReference type="GeneID" id="38778883"/>
    <dbReference type="InParanoid" id="A0A401GIF5"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="240" mass="26269" checksum="D1E384D599BDD3AB" modified="2019-05-08" version="1">MSYYPPHHPGTGSSYPYSTYHPPTPGAYSATPGAYPTTPYQSTYPPTAVTGYGGTWPYAYSYYPPQQSTQTALNVAKPTIGPATPVTTAAMPTPAPQRSAPTPASYTFTPTYTRESVFAASTGGAVSRGARKQSTMKGLFTKELRNLMYGFGDDRNPANDTVNVMEEILIEYIVDVCQTALTPGKKSRLSIEDLRRALSRPADAKKLARMEELLFMQEDIKRARAQFEESDMNQASSFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIL8</accession>
    <name>A0A401GIL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0404280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612963.1">
        <property type="nucleotide sequence ID" value="XM_027757162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIL8"/>
    <dbReference type="STRING" id="139825.A0A401GIL8"/>
    <dbReference type="GeneID" id="38778967"/>
    <dbReference type="InParanoid" id="A0A401GIL8"/>
    <dbReference type="OrthoDB" id="3364892at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40568" checksum="4C5821A23E305DE1" modified="2019-05-08" version="1">MSVTSRDGRQSDQEKPISLYAALARTGTRSLALYFSRPVRLFRPAKVSGWQSLKGLAVHHGQPLTPQYVSWLIKKQGFIVILKHFIPPIIVNGILGTVLWSTYSKTSDILEPYLTSHPTTLAAISGASAGGVQALVAAPAENLRFALEGSSSATGWSDAWKEVFRGTQPSPSMSVRSEAREAREVRIWMKEVGEMAGRGWDGWGWGCAKDTCGFAVFFAMFDLTRRIALSSKIVSQDFLETTRIKFLARRSTRTHAPRAVHGTTLVAGGVVAGLAYEVTCRPWDAARKAVHVHRTAATAESRTVQQILMQKWRDEGLLSYFSNPTLTHYDASLPPFRRRLYSAMRTLARVGPWGVGFLAWEAFGPGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ72</accession>
    <name>A0A401GJ72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0406200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613150.1">
        <property type="nucleotide sequence ID" value="XM_027757349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ72"/>
    <dbReference type="FunCoup" id="A0A401GJ72">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ72"/>
    <dbReference type="GeneID" id="38779154"/>
    <dbReference type="InParanoid" id="A0A401GJ72"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="370" mass="41212" checksum="460AD81CFCD170F5" modified="2019-05-08" version="1">MNVSRNILSHLRSPGYSAASQSRSFSSLPRPYHFHVGACWAGKPSDPHIPRLRTTPFPPDSEIGKWRDHTLSKHISPVGNHVGEDFFYVQDMRNQSGVSLGIADGVGGWVDAGVDPSLFSQALMFHAHRYSKFAWAGEPEIDPTQDYEEREEVEGWELTPSECLENSFHGVLRERAVIAGSSTACIMTLNASSGLLRAANIGDSGFLIIRSSNVIYQQPIQTHFFNCPKQLTKMPISRPRFSRACVDSPKSADLFETRLRDGDIVIAYTDGLSDNVWPEELISICSRIAHQHAVSESLKTRSSGSDEQQDSEDLLVQTMAERIVDYARLCMSHKLRQSPFERAAAREGMYFRGGKLDDVTVIVALVKETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJH0</accession>
    <name>A0A401GJH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0407010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613230.1">
        <property type="nucleotide sequence ID" value="XM_027757429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJH0"/>
    <dbReference type="STRING" id="139825.A0A401GJH0"/>
    <dbReference type="GeneID" id="38779234"/>
    <dbReference type="InParanoid" id="A0A401GJH0"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="594" mass="66327" checksum="5484AB687C09C463" modified="2019-05-08" version="1">MAKTCGACRERKVRCDGVTPICGPCSKARRPIQCIYVSSNAVASKGPLLQKGAACYPCRRKKKRCDAKHPFCTTCKVAGKEYDCQYEDNIERSLTEALIARTRDLEQRLAYFEGQSQASSAAPSQSVASSSCVTVEMNDFLSSLASFPPIFAQYPFTPGVNLAPNVEMPFPLVTSLPLQSVASQSEIISPLVDSHYLTTSTSYQDLDEFRALFISHHGQLGLFLSEEKTQAILLADLSGRVVHPVLVYAAQLMGCRLWQEQHRAVCTITTESYQLRSVQQALLNTGHPVTRLQVHNVLTIYFLIKQHMQEGRDQLVKAANLVMQYSLRFQSPAITGTNLLQEPNIEAREQICALSQLLYLDKAACIVLNESTLLSVEFEQDFATLSYVFPAISRHNLVVLRARSVFFLHQTRCLSSQPSSPVDFNVPAHSQGQWYDQYWHLLAEVSEHIAILSPSMLKSTAFRDRERGLTLKLCMLVSLTASAELHRLLASHHAESRLKCLDVVFEIVGITRGLKDDDYIFLDPILGICWTMVATIFNQERDHHNDKYSAVHWRSLLAVIVYSASKLGHTLPFMENSLVTINGAISTAEESSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJI8</accession>
    <name>A0A401GJI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0407090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613238.1">
        <property type="nucleotide sequence ID" value="XM_027757437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJI8"/>
    <dbReference type="GeneID" id="38779242"/>
    <dbReference type="InParanoid" id="A0A401GJI8"/>
    <dbReference type="OrthoDB" id="2748942at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="9452" checksum="B3B16E90AD8922C3" modified="2019-05-08" version="1">MCHWRRVRNHYRRCGHYIDLPDEEIQCADRYCKFSSTHPNDCVPPQCTESCWQYRQFPQQYTPVIDNFCPVCIQTGAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK75</accession>
    <name>A0A401GK75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0409470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613476.1">
        <property type="nucleotide sequence ID" value="XM_027757675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK75"/>
    <dbReference type="FunCoup" id="A0A401GK75">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK75"/>
    <dbReference type="GeneID" id="38779480"/>
    <dbReference type="InParanoid" id="A0A401GK75"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="294" mass="33462" checksum="C26B420B79BC0775" modified="2019-05-08" version="1">MSERKVLNKYFPPDFDPALIPRRKQPKNSQQVVRLMAPFSMRCNTCGEYIYKGKKFNARKETVDGEDYYGIKIFRFYIKCTLCSAEITFKTDPKNTDYSAEHGASRNFEPWREEQAVEEEDRLAKLEEEENNPMKVLENRTVDSKREMDILDALQDIRARNARNERVGQSVDLSEKLDVEEIETEEDRERKRQDEEDEKLVREVFSKITVPAGVSGSQPSESSSGSEEAAPTVVTLKRKADGAEPDLKSLLPESTRALIAQKSLGQPPVKRKKLDLKGSLGIKIKGRAVTKTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKW8</accession>
    <name>A0A401GKW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0412030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613730.1">
        <property type="nucleotide sequence ID" value="XM_027757929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKW8"/>
    <dbReference type="STRING" id="139825.A0A401GKW8"/>
    <dbReference type="GeneID" id="38779734"/>
    <dbReference type="InParanoid" id="A0A401GKW8"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="244" mass="27250" checksum="2704399A56096090" modified="2019-05-08" version="1">MDHHHHHHHHHHDDTHIHGDSHGHNYADANKQYFNETAQKWHAHPEAQEMARRLTAAMKSTYPTLFDEERTTVLDFACGTGLISRELCADTTSIVGVDISSGTVDQYNLRASNQGLAPEEMRAICVDLKGTEGELDGAKFDVVVCASSFHHFSSVKDVMRTLVFFLKPGGSLLVTDVMKDADESELFPQNVHHIVAHPHGFDKSDMRKVFEGAGLSDFRFTSAFSAKFHGKDVKCFLAKGVKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLA6</accession>
    <name>A0A401GLA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0413330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613859.1">
        <property type="nucleotide sequence ID" value="XM_027758058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLA6"/>
    <dbReference type="GeneID" id="38779863"/>
    <dbReference type="InParanoid" id="A0A401GLA6"/>
    <dbReference type="OrthoDB" id="2757790at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="377" mass="43625" checksum="587073F0D09A2B9C" modified="2019-05-08" version="1">MPIRRRRRRPNMLITMSVHTTFSCTKRWRKSVRIEDEVDEQDYNPETENATQKRTKPRQPDRTGTWQFMSVLLLDFPRKEVTIPDELEAFFNVLLFHIVRYTNSNIRNAKVFMSQYFDESMMDSLDAQYTCGSLKRNVIEMGVLKRRIEPIKFKDRNGLDHIPLNNIVKRLLRLFKAHYTVTLPDLLLQRHPAEDQCNPDGIDSEQKTLNSSAATDENTKKRSIEDLLVARVVAKFEEDRAKYSKNSRKQESPESSDNDSEEALEKEKAVAEKLNSQEHVYSFLINAYANEKWPEHDKIDDRVPSNSYADYRERGLKFPPAPSSSSGSESPSEARPTKRPRLPVQVACGMGPGQPSASYARRRGKQPGRLNADTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLG0</accession>
    <name>A0A401GLG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0500640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613934.1">
        <property type="nucleotide sequence ID" value="XM_027758133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLG0"/>
    <dbReference type="GeneID" id="38779938"/>
    <dbReference type="InParanoid" id="A0A401GLG0"/>
    <dbReference type="OrthoDB" id="2808701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="376" mass="42536" checksum="2789663B41A4BD9B" modified="2019-05-08" version="1">MSVPTDSVAFSENRRLLGKLLAYYSATSIEELNAQDDPEFWSRMLWSMWKWNYKLWGMYAQCFDMTDPTFPVVQQWDGERRFFSDGKTGEVMHEKTYRKAGRDEPEHIIYSLPRTENLTREGLACFPEGAMAANVRVAAYATTGHGTAVLKQVYWGTPLFGETSFQPDDKIRLQVSVVFSTPSIPGEKGQLKQVMLFRDDVTARPWFSQSQYWQGHFDAAFGSSPSIKKMDIQQASSVIFHGSSKRARGFKITPDMTNYARVTLGDGEIFDIEALAEGGSDAQFYALHDQEGSSALLNIVQSPEMGKALAAKWRVIWKLGDRLMVGVCAYDGETYKQQPAVYEFACDTWQTKLSTYAKNMGHLDSPEKTLQASWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLT9</accession>
    <name>A0A401GLT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614061.1">
        <property type="nucleotide sequence ID" value="XM_027758260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLT9"/>
    <dbReference type="GeneID" id="38780065"/>
    <dbReference type="InParanoid" id="A0A401GLT9"/>
    <dbReference type="OrthoDB" id="2811442at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="381" mass="41834" checksum="8100E263213DEA11" modified="2019-05-08" version="1">MARTDPRIKAIVDGLLPRCDVLLFSLITCSVQLEQCHLIVASYGVTNTENLGVLFEICRTTPMCGHHLKRLRAQMTWGNMAQCHKDVAALCLPPVLGDAGYLRSDEPQSEAMPLPTSPMINTSLPPSSLPSSSPLSSSPSTSPVFCRRGRPLLNSATVSVLMVCKGSDIPLIIPTWGIWHEDYLEFKFKQSFIETVLIDDSQGLSPYQRYCPHLKKFVDYPKHTDKQYLLLGDTPVYRKKGSTWNTSAAQIANIQVSATAHLPVLMAAIKTFAKNVLTTPSSSSGGSQSMLSTPSTPSFSPVCDAASSSSSSRCVAKRSLSPDVRTEGRKFRRMDKGKAHEVIECDIELTDNEVEAEIIPNDDVPGESIEIVDGKEYYYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM17</accession>
    <name>A0A401GM17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0502690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614135.1">
        <property type="nucleotide sequence ID" value="XM_027758334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM17"/>
    <dbReference type="GeneID" id="38780139"/>
    <dbReference type="InParanoid" id="A0A401GM17"/>
    <dbReference type="OrthoDB" id="2769307at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019092949" evidence="1">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="171" mass="18225" checksum="DBFCB2E7F759FBB5" modified="2019-05-08" version="1">MRFQPLVVLSTLVALAGHAASSPTKRQTIYNYGTIDEPVVGTAIAPGETFPFEFTSVNLCESGYNPVSVWLLAEPPSDETFAVSGNYGGFASGDYLYQFGDYLIPNFGLPPMNTPVPSSLVMPDLSALGEGVYSNATLYLAVVETYLDCPPDIPAEYGVTSNAIIYNTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMD8</accession>
    <name>A0A401GMD8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Large ribosomal subunit protein bL28m</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0504160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614281.1">
        <property type="nucleotide sequence ID" value="XM_027758480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMD8"/>
    <dbReference type="FunCoup" id="A0A401GMD8">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMD8"/>
    <dbReference type="GeneID" id="38780285"/>
    <dbReference type="InParanoid" id="A0A401GMD8"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_bL28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_bL28_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="132" mass="15128" checksum="B315AD0DC6CD8D31" modified="2019-05-08" version="1">MFPSLPFFTGQVISAPFKRAQLGLFQGKTKQYGNNVPFSKHKTRRTWLPNIQSKRFFSEALQEYIRVKVSTRALKTIKKYGGIDQYVLRTKADLLGWEGMRIRVVVRERQEANAVVQQQLPTSQQPAVQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMH8</accession>
    <name>A0A401GMH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="4 12">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">5-proFAR isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0504710</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="4 12"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614336.1">
        <property type="nucleotide sequence ID" value="XM_027758535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMH8"/>
    <dbReference type="FunCoup" id="A0A401GMH8">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMH8"/>
    <dbReference type="GeneID" id="38780340"/>
    <dbReference type="InParanoid" id="A0A401GMH8"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04723">
        <property type="entry name" value="HisA_HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000110">
        <property type="entry name" value="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011858">
        <property type="entry name" value="His6/HISN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02129">
        <property type="entry name" value="hisA_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090:SF2">
        <property type="entry name" value="1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE83423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="261" mass="28463" checksum="662344454914439A" modified="2019-05-08" version="1">MSSATRRHTHFRPCIDLHKGEVKQIVGGTLSEAEPCNLKTNFVASHSSAYYAELYKKHGLEGGHIIKLGDGNDEAAKEALHAWPGHLQIGGGVTDRNCQEWLSAGASKVIVTSYLFPDGIFSLQRLQVISSLVGKDRLVVDVSCRKRGEKWLIAMNKWQKTTDMEVCKESLELLSGYCSEFLIHAAEVEGLCQGIDESLVAKLGEWVTIPTTYAGGARSLSDLGTVNNLSDGRVDLTFGSSLDIFGGTLVQFSDLVKYEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN60</accession>
    <name>A0A401GN60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0507220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614580.1">
        <property type="nucleotide sequence ID" value="XM_027758779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN60"/>
    <dbReference type="FunCoup" id="A0A401GN60">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GN60"/>
    <dbReference type="GeneID" id="38780584"/>
    <dbReference type="InParanoid" id="A0A401GN60"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="273" mass="29328" checksum="7776727A0343825E" modified="2019-05-08" version="1">MFITGASSGIGLASAKLFFEKGWNVVATMRTPEKDTELKQLDSSRMLVLRLDVQDLASIAPAVDAALAKFGTFDVLLNNAGYGQVGPFEMTPREKIQEQFDVNLFGLMDVTRAVLPHFRKHKKGGIINVSSGAGHSAPPMMSMYVASKFALEGFTEAVAFELASQGVFVKTVVPLDGIGATSFTARATASAALDAALMPDYGAFVDKSVEALGKLGAGNGIESKDIAQAIFEAATDGTDQLRYFVGDYERSLVKVRYGSNDQEYVAHVRSFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN71</accession>
    <name>A0A401GN71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tigger transposable element-derived protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0502410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614107.1">
        <property type="nucleotide sequence ID" value="XM_027758306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN71"/>
    <dbReference type="STRING" id="139825.A0A401GN71"/>
    <dbReference type="GeneID" id="38780111"/>
    <dbReference type="InParanoid" id="A0A401GN71"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="322"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="569" mass="63098" checksum="0779248A91546DFF" modified="2019-05-08" version="1">MYHQPTQPPSSDGHVHFSPTSPPPPMDWHNNTSNGPVSTRHPTNVYTMMNPAPNHVEYHHHPHPDANPFVPPSQPDSFAHRHPHLPPINHHQPNDSLAFHSPQVESSIGPSRILTRRRARAAEQSQHSPDDQNHASNYSYELQRPQQSSAFSGHPQQMSRAATPADAQPEPVFGMRGGIPPYMLNTGHAYSPYTFVPSHSRSTSGSGSGSGSASTNPRSASPALSVASALTSASSASASGSHNTSSLPAAPLVVPDTVLRKNRKQKLTNADRKQICRYQEENPTMKQDQIAAHFGVERSTVSKILKAKQNWLNKADDEVTDRSSRTRPTKFPWLEFRLLDWLKECKKNKTIITDALIRNTAKQYALDMGITEEKFKASSGWVENFKNRHGIRKGIFNGYPQQKKASRVAPREDNNAGVPEYLPDQPAQVQHEGYSMRLEQDGHTVDPILRPAWTTDSGMHLQLPSSHSPVIEPSPSPPPLPTEPMPITVPDGPDQGKVVEVVPKIAIYSDGQCPTAEEAEMYFDKVLTYIEHEVNDDAITEPERRALYAVKCNLFQRNVGVPYDRSTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNM1</accession>
    <name>A0A401GNM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">28S ribosomal protein S5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0508840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614740.1">
        <property type="nucleotide sequence ID" value="XM_027758939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNM1"/>
    <dbReference type="FunCoup" id="A0A401GNM1">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNM1"/>
    <dbReference type="GeneID" id="38780744"/>
    <dbReference type="InParanoid" id="A0A401GNM1"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="148"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="328" mass="36952" checksum="A6C23ADE9432EF33" modified="2019-05-08" version="1">MNKLSGTLVSGVSRTARTRRQCRLLPSVRHYTDVPSSSNVSKPPSQEEVDKRSRLYLQKLQEDGGFPDLMEPDVLMDLHDSATFPPSRFTPYENKVVIRNDPSMFLALKEKLGETQEKHPDAEEHERDSEPDPLNFLHIGSRDIANKLYQYPLVSRRVVQQTGKGKVARIHYMMVAGDMNGLVGVGEGKATDGAHAMHQALVEAVRNMDYVERFEDRTVWTEMENKFASTRVIIRPRPVGFGLHVNPHIYHILKAAGIRDASAKVWGSRNPMMVVRATMQMLMPGNAPMGMGNGVGGKGRRLDKRVGMRSPDDIARDRGRKMVPLRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP26</accession>
    <name>A0A401GP26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0509580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614812.1">
        <property type="nucleotide sequence ID" value="XM_027759011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP26"/>
    <dbReference type="STRING" id="139825.A0A401GP26"/>
    <dbReference type="GeneID" id="38780816"/>
    <dbReference type="InParanoid" id="A0A401GP26"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="31536" checksum="BFDA36B3B7EC8F14" modified="2019-05-08" version="1">MSSTILQTKSARTAPTRLDGRKTDDLRPLTITYEGLARSDGSARFGFGPALTLASLSGPIEVRAALENPTQATLDVHVRPLAGIPGTDARALASTLKLLLTPSLFLNQCPRTLVQVVVQALCDRPGGAKGWGSVLVASAVNSASLALLSAGSVPMRGVVCAIAVGRVVLPGAAAGSGVLVLDPSDEELPRLTGGGCFAFLFSSALPSAIQAEEDAPPCELLWTDYKCQNGFGEDELFRARQIASGGAKAVWRAMKESVARMDTTMHSHSSKSGEEHRGNAMDEGGGESAEESEVDDDKMEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPK2</accession>
    <name>A0A401GPK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0507400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614597.1">
        <property type="nucleotide sequence ID" value="XM_027758796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPK2"/>
    <dbReference type="GeneID" id="38780601"/>
    <dbReference type="InParanoid" id="A0A401GPK2"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF91">
        <property type="entry name" value="GENERAL ALPHA-GLUCOSIDE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="662" mass="72017" checksum="2F61901043B8EF46" modified="2019-05-08" version="1">MTGFAAVPIAEEGGEDSRLTGVSKVLGPRWLQLPTLTVGLLGVQVFWSIEMSYATPYLISLGLSKSAVAVVFLAGPVSGLVVQPVIGLLTDNSKSRFGRRRPYMLAGTCICITAMLLLGFTRPFASLFVPSGSIANHLLTIWLAIIALFSVDFSINAVQAVDRALVVDILPPSDQAEGNAWAARMLGIGSVAGYFVGNVDMTTVFPFLGDTELEVLSIVGSFFLVSMHLITAICTKEKVVVANKLSSGSFIKELKTVWYNARNLPSVIRQICIIQFCAWLGWFPNLFYTTAFIGDLHKRAYPDVAQDDPVLDAEAIRLGSRALFYSSILSLSCNIVLPFFVSEAATSREMLERKLSSTKNIWAQWYHRMKVHLATLWAISHLVFAICMAATFFYSSVAGATFFTTLTGFSWAITQWAPFSLLAEAILTNPLPANEDANSIILHDTRTQRRSGDITFGSDANERQFLVAADDDVDDDSTLEDDVHSFRSSASMEIDLNDDRRSADGVHVHENPLMGNPAARASHLQLPSSIDGGDEEDDEVSQKHHGEGGLADKAGIILGIHNIFIVMPQFIMTALASIIFAILEPGKSVLSGHRGGFRNSTLPATNSTGNNTEAELFALDFRDEVNAAARPNSYAIVFRLGGIAAAIAFVLTVRLARQLRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPP0</accession>
    <name>A0A401GPP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0507800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614637.1">
        <property type="nucleotide sequence ID" value="XM_027758836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPP0"/>
    <dbReference type="GeneID" id="38780641"/>
    <dbReference type="InParanoid" id="A0A401GPP0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="423" mass="47632" checksum="EFE35A35E2A91EA6" modified="2019-05-08" version="1">MHATDSESIISIISPRKLHDSVTQVDNPSLASCPWSYSSPHSVRVRPQDVERFLNFLESDPRRHECDAVQELEISNFPVMVACCDFDSVLVKFADVTEVSTSTLYTVVSKLPSLKKIFLDEVSLLGDTSHVSERPRPVLDSFRLRFEDPSCTTYGLLQLIGFFSEIRELSFEAPKVDFYGQLGEMLKNVLNKFSSPVWPWWSVRDSESPPLAVIRVFTLKLGEYAGFSLALHALLKVSRIEALIIVSHTSHTAQHIRDLAQLLQEAIPSVQDWMLDFDATALVFKSGLVPSATWDVLKLPSRTSLRELFFTVLFSQHHDVAAPVDISAWIVYIDILSLAPQTVRHIGFTLKFTGVLADQLRNVDWNRMHGVLQALKGLETVEFKFRKLDNNVDMSAPDVHNSCDTIRNALPTNSFTVTVNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPU6</accession>
    <name>A0A401GPU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615168.1">
        <property type="nucleotide sequence ID" value="XM_027759367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPU6"/>
    <dbReference type="GeneID" id="38781172"/>
    <dbReference type="InParanoid" id="A0A401GPU6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="171" mass="17872" checksum="B5201ADC88852253" modified="2019-05-08" version="1">MKVPPQSPPEAQTCDTTSRYDWMVIRLALEYTLAWVIAYESNNFCQCRQPRHNDAELITELIMALGDRGVTHPVDGNGEFIVDSDEEDVDLHRVTAIAPTATVAAPPAAVLVFTVPANTGVLPAVPTATAPAATTPAVAVVIAPAGPAVPAVDAPVPIAPIVIAPPTLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ12</accession>
    <name>A0A401GQ12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0603030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615238.1">
        <property type="nucleotide sequence ID" value="XM_027759437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ12"/>
    <dbReference type="GeneID" id="38781242"/>
    <dbReference type="InParanoid" id="A0A401GQ12"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="122" mass="13438" checksum="E059BFE73F5D8495" modified="2019-05-08" version="1">MRNEGGGAWNRLDVNADGAQNFAIESADSEETGDNSTMINMVSMTRQREVTTDTPDSELHRTQQGQAISARKVYHLPAQAFLSTDLGEVIWVRLQCQNSFLDPLSVDFQLQPPSGEQAGARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQN8</accession>
    <name>A0A401GQN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0605170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615451.1">
        <property type="nucleotide sequence ID" value="XM_027759650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQN8"/>
    <dbReference type="STRING" id="139825.A0A401GQN8"/>
    <dbReference type="GeneID" id="38781455"/>
    <dbReference type="InParanoid" id="A0A401GQN8"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000160">
        <property type="entry name" value="Polyubiquitin-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="37"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="135"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="216" mass="24100" checksum="61E0D5D3F4DBBF09" modified="2019-05-08" version="1">MIPQSCPLPSATSEGSLPPQKENDKLKAFNLMYPGQIQIFVKTMNDMSISIILHPTVKVVSMKGKIEETLHIPAADQRLLYSGQELEDDRTLEDYTLESKSTIVIATHSGKLYAQPLQSTETETKTSTASSTAEVQIFVRNLNGKSMAIMISPSDTAKTLMDKVQEKTGIPPEEQRLLYGGKQLVPERILSDYNIQKESTLHLVLRLRGGTSHERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSR1</accession>
    <name>A0A401GSR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0704340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616160.1">
        <property type="nucleotide sequence ID" value="XM_027760359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSR1"/>
    <dbReference type="STRING" id="139825.A0A401GSR1"/>
    <dbReference type="GeneID" id="38782164"/>
    <dbReference type="InParanoid" id="A0A401GSR1"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="160"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="556" mass="60935" checksum="009042E1D369B0EE" modified="2019-05-08" version="1">MAEELGLMHDISSFLHQPLTESLLSVHPNQLCSPSFDIPSLWISWWDWAGETQVENNLLPEHASAPTVPKSLVLLRYYLCGSDPNIAGNSCIPYDLRILVDEARRLQISRQTGLARPALCTGNHEANDAKTEHGGSGSDDGPGVAFLSFQDQRLRGMSPKKAHEVLRMTECISRLVSSCTRLGNVRHAVDIGAGQAYLSRQLRDDMSMRVLALDWSDTQTKGAARRDEVSQNTGHPQKAASDPAASAASRPMCGKDLLTYKTTRITADSLLKVTDEWINDQVLGNSIPHLHVCNLDGTQSDQEPVPVFLVALHACGSLTPHILRAFLSSCRADDTTRTWVSSAAVIVGCCYNMLDPKDFPLSDALTSSSQTAQVVLTPSHLQLAAQVPSQWLRTEDTLNAAKLAIKKVVWRALLQGMLEKRRAETGSLDMHEGQRETAGAGAGPRRLGRLNNSVYVDWGIFLAQASSKLGVDLAESEGRDMAIESRMEVFHVLRCILGPVVESLILLDRQQYLKEKLQDTEMDVRLVNLFDQASGSGRNVAIVIAPRLAEGVLPWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSW6</accession>
    <name>A0A401GSW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposon Ty3-G Gag-Pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616172.1">
        <property type="nucleotide sequence ID" value="XM_027760371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSW6"/>
    <dbReference type="STRING" id="139825.A0A401GSW6"/>
    <dbReference type="GeneID" id="38782176"/>
    <dbReference type="InParanoid" id="A0A401GSW6"/>
    <dbReference type="OrthoDB" id="2793220at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="232" mass="26553" checksum="85CAFD6DCB035D8E" modified="2019-05-08" version="1">MNTVNNSTGFSPFQLKTGHSPRLVPPFSQVSLADDTLDEATRAAELFTCLDTDIMEARDNLFLTKVNQAALANRSRSEEISYAVGDKVMLSTFHRHHDYMQRGDNHIAKFMVRYDGPYSVLHSYPEFSAYTLNLPASTNIFPTFHASLLKPWFKNNPELFPSHQCSQPGPIITTDGAEEWEVESIVDHHPRGHSFQYLVRFCRYGLEHDIWLSRREVNDLAALDEYLLHSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSY3</accession>
    <name>A0A401GSY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616206.1">
        <property type="nucleotide sequence ID" value="XM_027760405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSY3"/>
    <dbReference type="GeneID" id="38782210"/>
    <dbReference type="InParanoid" id="A0A401GSY3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="7310" checksum="EB8760B76172EFE8" modified="2019-05-08" version="1">MMNTPPPTPRRAPPLANSAPRTASATHPPVPPPAAPPAAPVAPPTAPAAMEPLIIPAPAAAAFMVAGEDDIAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTF4</accession>
    <name>A0A401GTF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0706570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616383.1">
        <property type="nucleotide sequence ID" value="XM_027760582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTF4"/>
    <dbReference type="GeneID" id="38782387"/>
    <dbReference type="InParanoid" id="A0A401GTF4"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12624" checksum="62BB3073173F0994" modified="2019-05-08" version="1">MKVCNDSPPYQSKVRRLLAEYAKPCTRAEDYYAPFVNTFNHALEEMKECSLPLLREIDKNEDLDIMFHRNDPKALTGIHGGLKTLRRPDVVLVAHGSAFRAAGDSARVPGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTF6</accession>
    <name>A0A401GTF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0800220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616418.1">
        <property type="nucleotide sequence ID" value="XM_027760617.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTF6"/>
    <dbReference type="GeneID" id="38782422"/>
    <dbReference type="InParanoid" id="A0A401GTF6"/>
    <dbReference type="OrthoDB" id="2757440at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="536"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="789"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE85505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1394" mass="154198" checksum="E6FE3DDBC65F9674" modified="2019-05-08" version="1">MSLTSESHLSHLNIVPKLAADGSNWITYKERMFTVMGSRGLLRHLQGTARRPPNPPPFPMPSPAQAAMTASTTPATAASTTATTGTGTTTTSATTTPAARQAQSSMTPEEYLKTVEAAEQKLDEYVQKEYAARQQIYGTISDQLLLRVKKLGTAADVWLAVQNEYESKSDMYSGALRTRLQNTKCEEGADVRAHLDTLAKMREELASMGAPISDADFSAHVFASLLETFSPLLQALSTAARAAKTTLSADDLLASILEEHDRRKAHLKPESALSGHFLRDCWREGGGKEGQGPKDQSPKKDSSGSKNAKGKPAANAAVGDSATDHAFTATFDSTALAAKPSEVKVEVYDSGATRHMSPYRDAFVTFKAISLKPITAADGRKFHATGEGTMRIEIPNGDQSMTVMLKDVLDAPEIAFALISIARADAAGYSTTFENGECRLYSRRHSRTIGRIPSTNGLYKVEHPKSREVASVAEESKDECALVSLSVMDFHRRMGHIAPAIAERLVREGRVKGIQLTDKASSDKNCESCIQAKITRQPVPKEREGGRAKELGDWIHSDVWGPARTETLGGKRYFTSFTDDATRWTDLYLLRVKSGAFSAYKSFEARLKTQDGKAIKALQSDRGGEYLSQAFKDHLEVQGTISRLTVHDTPQHNGLAERINRTLPEHARAMLITAELPKSLWGEALMHATWLKNRTSTRALDGKTPYEARYGKLPDLHDLHEFGAKVWVRIEDADKLESKARAGHFVRYTDESKGYCVYWPEKCSVSVERNVHFINQLIIADEAQPEGAKETVVLTSPATPSAPAQEPEYEPRTSETQAAPPATSPTASLTPSSDATAKEPASAKSDSESGTGRSQCARKASAYVKRLNDGSGVMDGRKSQPKYPKGLQPGDLMGATAMTVEDSEDSESEEDEPIFAMPAAFAVHEGQEPRSLEEAMQSPDWPQWQQAIEKEMQNLRDHHTYDLVEPPENTNIVGSKFIFRIKHNANGEIESYKARLVAQGFTQVPGVDFNDTFAPVAKLASIRIILALAARHDWDVHQMDVKGAYLNAELEEDIFMKQPPGQAKRGREHWVCHLRHMIYGLKQSGCQWFKKISTALNEMGLSRSLVDHCVFYLDEDNDSITLIIALSVDDTTIAGMNSAVLWFKTEISKHFEMTDLGEMHWILGIEFEDMRNVPYHEAIGSLMYAALGMRPDIAFAVMALSQFMQNPGRAHWEAAKRVLRYLKGTRERWLTYGQTRDGVEGFSDADWGSSEHRHSISGYVFLIDGGAVSWSVKKQPVVALSSTEAEYIALTHAAKEAIWVRYLLADILDPDINKFALRLHTDNRSAIALAKDNAYHARMKHIDIRYHFLHEAVDSAIIILLYRRTEDMPADLFTKSLPRVKVEHLASLMGLHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTK2</accession>
    <name>A0A401GTK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0800690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616465.1">
        <property type="nucleotide sequence ID" value="XM_027760664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTK2"/>
    <dbReference type="FunCoup" id="A0A401GTK2">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTK2"/>
    <dbReference type="GeneID" id="38782469"/>
    <dbReference type="InParanoid" id="A0A401GTK2"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE85552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="180" mass="19443" checksum="8391037893B2B89C" modified="2019-05-08" version="1">MASFLRRFATSGSAAKTPMSNVFFDVAVDQKPAGRIVFRLFDDVVPKTAKNFRELATGQHGFGYAGSSFHRVIPNFMLQGGDFTRHNGTGGKSIYGEKFTDENFQLRHTKPGLLSMANAGPNTNGSQFFITTVVTSWLDGKHVVFGEVVDGMDVVKQVEAVGTDSGRPKSKVTITSSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTK9</accession>
    <name>A0A401GTK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0800300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616426.1">
        <property type="nucleotide sequence ID" value="XM_027760625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTK9"/>
    <dbReference type="GeneID" id="38782430"/>
    <dbReference type="InParanoid" id="A0A401GTK9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="27861" checksum="CAEA9EBDAAACE013" modified="2019-05-08" version="1">MPSVSSTTGFSPTSSPSSTADQSFPATGSFLPATGSFVPSTALTPSTVDITSSLMTDSFVSTTSPSFSSTRTAVPVTTSASSTELHRTTSVSIGAIVGPVLGGVTVLALILLAVLHRYRQRSARGNGHASSERNLLPDEDETDGTQMAQEMPSNIDTATTTLPIDAPSSPVTREPRNSATSSNLRSSFVPSTNGLPLLDFSTGYDVNLGASAGAKSLRFLATSSARHAATATAIAVAGTPQEELNRNPSLRSAQPSEISVVSDPPPPYTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTP0</accession>
    <name>A0A401GTP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0702900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616017.1">
        <property type="nucleotide sequence ID" value="XM_027760216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTP0"/>
    <dbReference type="GeneID" id="38782021"/>
    <dbReference type="InParanoid" id="A0A401GTP0"/>
    <dbReference type="OrthoDB" id="2796682at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="128"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="184"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="712" mass="79483" checksum="06EBFF69C99DFACC" modified="2019-05-08" version="1">MDRPQGAYLASFLFHSNDSPIERSRSGHWQMETSSLQDVSDLSSRRPAGSNLENHRPTNSSSYPRHRSPFFPRVATGNTTYSKSSSSKKGISTFDISAVEVQEESKDEPVKLPTPPLQDDHPDTSAAWAKCAKDLWEHDEAAVKEWKEEIDTLLVFAGLFSAVLTAFNVQAAFSGNGSGGLSNSSPPTYVAANALWFASLVCSLASASIGISVKQWLNHYTTRNSTISRQSVRIRQFRYRGLIRWRVVNIKNFLPVLLQTALSLFFLGLLLILWNMNRVVASTTTALVVSLALFTSSTVMLPAIACDSPYKSAPAWWFFLVTRWTNITFATSWRYLKHRLRTILYKIVRQESYDGSTDPVYLFNVRPYRNWTEREILYVRSLTSPIDSYALAKADETMMDDTFLDEVIRPCLQDIALEDALPCYYSILQYRAHRFKDNLPDWNGDEHDGHAIVTMGQMTIDMLSRISSADHDSVSHQKRLFELLDRLFEARPAGIPAGYGRLLGILTKMLGDNVAAAAAIRETAFAWIVKLAVHHQIDAAEKDDALAIVAYAAAIREVHDGPAYPRACLAGLHVSELLTKDDDYKSLRGELKDMLDSLEGYLSVPASQVIADRANLISFICFLPSVVKLGRRDAGLVSAGLVELLLKVFEHSLDVLSSSEFRKQEVMASQVVQRILSDLRSLQEELRAAEGKSPQDESLPEGITSNEQASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTR7</accession>
    <name>A0A401GTR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0800970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616493.1">
        <property type="nucleotide sequence ID" value="XM_027760692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTR7"/>
    <dbReference type="STRING" id="139825.A0A401GTR7"/>
    <dbReference type="GeneID" id="38782497"/>
    <dbReference type="InParanoid" id="A0A401GTR7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="37967" checksum="83F20FE8D362080F" modified="2019-05-08" version="1">MVEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSIHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRIKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDMITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV90</accession>
    <name>A0A401GV90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0900280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617064.1">
        <property type="nucleotide sequence ID" value="XM_027761263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV90"/>
    <dbReference type="FunCoup" id="A0A401GV90">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GV90"/>
    <dbReference type="GeneID" id="38783068"/>
    <dbReference type="InParanoid" id="A0A401GV90"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019484306" evidence="5">
        <location>
            <begin position="23"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="486" mass="50286" checksum="F13B22D812530CB7" modified="2019-05-08" version="1">MYFLSLTLAASVFFSLAPVIIAAPHPTVPVGKSIALVRRPKQQRDLAEQGSHAQRRRLALEAKYGIGSYKNKKRESGNNLLVNQDADSDFYGSIAVGTPPVSYNVILDTGSSDLWLASATTTGAVSNVPSGVPTFEPSKSSTFQSLNQSFQIQYDSGAAQGVLAKDTVQMAGFEVAGQEFAVVSEVSQGLLNAPVSGLMGMAWQQIASSGATPFWETLEQTSGSLSEPLMAFQLTRFGNDTNARQLEPGGTFTLGGVDSSLFTGNIDYQDIPSGEIGYWIQELSGLTSQGQAVSLENGSASYAAIDTGTTLVGGPASAIAGIFAAIPGSAPGTGQYENYYTYPCSTSVNVTLKFGSSSIAWPVSNADFMLEQISSDTCLGAFFVVDNSGTSAPAWIVGDTFLKNVYTVFSASPPSVGFAQLSSTASAMNGVNAAVPSPTIGSVTGAVSATGVSPNQDPVSNGASPSHDSMSVLLLLVVGTVVGCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVA0</accession>
    <name>A0A401GVA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617070.1">
        <property type="nucleotide sequence ID" value="XM_027761269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVA0"/>
    <dbReference type="STRING" id="139825.A0A401GVA0"/>
    <dbReference type="GeneID" id="38783074"/>
    <dbReference type="InParanoid" id="A0A401GVA0"/>
    <dbReference type="OrthoDB" id="3199068at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="27364" checksum="FE512E96BA0F8E02" modified="2019-05-08" version="1">MDPVNVLQPVRDAEFYFEYIVFLVEGTLFKVTRRNLESDSEVFRDMFAMPVSGNATADGSDDEHPLRLEGVAKEDFAQLLRVIYPKYYEQSEQLTSEEWISVLKLSSMWNFERIRTTAIRNLSHNMQGDPVGRLVLSKKYAIGEWMVPALNALARRTQPLQRADVDAIGLDDALKLAEVREVFRGSNSTCYCTCTKCAAQHGYGTRQPADRENYDFTREILQIFDLQSAPLVPVYALRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW03</accession>
    <name>A0A401GW03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0902280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617262.1">
        <property type="nucleotide sequence ID" value="XM_027761461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW03"/>
    <dbReference type="STRING" id="139825.A0A401GW03"/>
    <dbReference type="GeneID" id="38783266"/>
    <dbReference type="InParanoid" id="A0A401GW03"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="197" mass="21523" checksum="724D3E4C1E549DC1" modified="2019-05-08" version="1">MPSGAQHNVLHSHSRFHGATLSSFSSIALDPYPLVAFSLRIPSRMAMSLKSAHVSLPVASHMVVNILSAAQVDTAVRFARPDLHPDPFAGSPYFLSAEGLPVLKDSVGALSCKLVAASWPLHDLELLEGRSNEETVWEGEGVASELFIARVTRVELLTDPEPKEDEKDLRTSPLLYYRRAYSTTRDIPGRSASETKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW23</accession>
    <name>A0A401GW23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616877.1">
        <property type="nucleotide sequence ID" value="XM_027761076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW23"/>
    <dbReference type="GeneID" id="38782881"/>
    <dbReference type="InParanoid" id="A0A401GW23"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="63" mass="5900" checksum="C96384CE5CB08054" modified="2019-05-08" version="1">MPPAKGSKATGAAKNAPAETARPAATQAKAGGDKTAPPRAPTGTRNAAAPPPSGGKAPKGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW44</accession>
    <name>A0A401GW44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616897.1">
        <property type="nucleotide sequence ID" value="XM_027761096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW44"/>
    <dbReference type="GeneID" id="38782901"/>
    <dbReference type="InParanoid" id="A0A401GW44"/>
    <dbReference type="OrthoDB" id="3269456at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="313" mass="35012" checksum="707BFE173E9FFE7B" modified="2019-05-08" version="1">MAKVFQDARCVKLFDEWTTRTKAPNPEMGADGQGSQFLLETYDQFETVERQFDVQVSSGGYLYLVWRSSREEVTLRVSGFVSQMSLLPPFRRSFRLPRGNPNLALQTVVVAGEGPAFRRAITARSNILRFMEMHARRGTTSVIDDVWLGAMPCFIAETRVLTPMVEAPLFDSADLNMVIDPYGALAELVAGGRLSWTSDNVVSCMELKGEYDDRWSTPVQSSLDMVRAGELVELSVNFRLREHVSPNGANVGRKFLTRLDTVMIVSRLGMKLIADCESEHLSMMRIAATADNTGGGKAPKKRRFSYLHIGQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW53</accession>
    <name>A0A401GW53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0902910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617325.1">
        <property type="nucleotide sequence ID" value="XM_027761524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW53"/>
    <dbReference type="GeneID" id="38783329"/>
    <dbReference type="InParanoid" id="A0A401GW53"/>
    <dbReference type="OrthoDB" id="2735833at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="264" mass="29558" checksum="450675842CF32388" modified="2019-05-08" version="1">MSPAAIHSIANVFGSTKDIGEILKSFDFNQMNVKDSSRDDHLNIGLAPSFGTLDRESIKNVDEKLKVMIVGTTKLIAKMPPHKRSWDNIVSVLMQNPLIEPLDDGISRADKLIKEGVHFFKFDGAPELAVVREVHNWFVALIADEDVLNSTKIDIDVMGSIVAQTGATVVSLETLIYKQESHSKTLVDIGVLRYPDPDHPYFKVYRIKLTAWSQSTRVAFIQGDENGITGEYNVRRFRPRASVIAEMREKVTKKAAKEAESLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW99</accession>
    <name>A0A401GW99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0903180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617352.1">
        <property type="nucleotide sequence ID" value="XM_027761551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW99"/>
    <dbReference type="GeneID" id="38783356"/>
    <dbReference type="InParanoid" id="A0A401GW99"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="152" mass="17245" checksum="B631618D79EDE75C" modified="2019-05-08" version="1">MLGRSEPKPGDNRRQYYGFLVPIGNEFFFDYCKRKSVCLTWPDGRKLDPFWMGWKEFEKVVGCLILPQPVTSGESDIEGPGKLPEDDGYCLAIAAYPQMNYLKESKPTEEQINAIIKELNDCGVEVAQSDPLWYRGGITDIMWMPAAAIPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX17</accession>
    <name>A0A401GX17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0906380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617670.1">
        <property type="nucleotide sequence ID" value="XM_027761869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX17"/>
    <dbReference type="GeneID" id="38783674"/>
    <dbReference type="InParanoid" id="A0A401GX17"/>
    <dbReference type="OrthoDB" id="3269001at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1004" mass="114814" checksum="FD2D8203540B0F61" modified="2019-05-08" version="1">MEAIVDRPELFQPPCSSPEVAADIWDQPLLHDLPGPNGTKFMDADANEGRYVFSLCMDGLNPFGKGGPSASVGAIYMALLNLPPEMRYKIENMYLVAIFPGHPSKEQINPLLAPLVDDLLDAYDSGIRFSETPLHREGKTCRCAMIPLVCDLEAARQMAGFSTHGHTFFCSCCYLKLSDIENIDYWTWPERTTEQHRASAEQWKNAEPEERQKIMDDYGLRWSELLRLHYWDPIKYTALEAMHLLYIGLLGRHIDKVWGMSAKHADGLRGIVDDPKPTQKETEQALHILRTGSGDELSGLRVEALKQLCRIKMLRSSGRRGKLLKRLIAYRKEQGWFDSNGNPLSDEQQPLRPDPAVNNVPHPKELAVALVAVDSKPGTALQRLRRDVLREVCMQKLGGTIHDYEKKTKDELLALLTQYRLDQKIADKHGNLFAAQDLPVSRSRVVTKEELEDAVEKFDTGTKSALNKLRLPVLIQLCCRKLPQDIVDTLKKKSDVQAAIHQARIKMGITDNSGKLLVRREKHLPQSTGEAGQVEVAEDILEHGATSKLMKLSTAVLVMLAAKKFKGKTLQKKDDVLQRMRAYRLAEGITDADGKLIEGRTRSRRVLGRRMLSIIWKDMDAVVLPSTLTPPPRRPGTSSGKLEADELRTFCTINLTISLIWAWGSKPSDSREYRMLQNFMDLITAVKLASLRTMTSERITRYRRHMHRYLRTLLELFPGTTISPNQHNSLHLPEHLERFGPTHSIRAFSFERNNGDLQTILTNNKMVDLPGTMLRRFCMRQNLRSLFNPESLPQSISSIIAPFISSFQSEHRGTLLQDMLAFEDPLGDPDLDNDELEEETRDFSRLGDQEWNALQSWFAGHNFIRPHINRYVVRNKKLEVQDDIYKPVTTSRGDSYIVFQCADDADWRAGRVVDIFTHSYRQENIDVRRNFLLVEEYIALEIRHIQFDPYRKFPFVGGRLFYDKVRDQLIVLEVDEITCHFAHTRRTTPSIDIDCVHVLPLNKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXJ7</accession>
    <name>A0A401GXJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617826.1">
        <property type="nucleotide sequence ID" value="XM_027762025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXJ7"/>
    <dbReference type="STRING" id="139825.A0A401GXJ7"/>
    <dbReference type="GeneID" id="38783830"/>
    <dbReference type="InParanoid" id="A0A401GXJ7"/>
    <dbReference type="OrthoDB" id="3227225at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="196" mass="22146" checksum="3504D88067A5D818" modified="2019-05-08" version="1">MANNTWDIVPLPPGKRAIGSGWVFKVKHNADGSVEHYKGRLVAKGYSQRPGFDYTEVFAPTFRQPALHLILALAAAEDLELRSVDISSAFLNGDLEEEIYMQQPEGFHQGGPEMVCRLNKSLYGLKQGARQWNKKLHEVLTKMGFTHLQSDRSIYVYIRGDVRIIVPVFIDDMTLASKSKKALDDTVKESKSYFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXR1</accession>
    <name>A0A401GXR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis uroporphyrinogen III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1002540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617921.1">
        <property type="nucleotide sequence ID" value="XM_027762120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXR1"/>
    <dbReference type="FunCoup" id="A0A401GXR1">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXR1"/>
    <dbReference type="GeneID" id="38783925"/>
    <dbReference type="InParanoid" id="A0A401GXR1"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="288" mass="30964" checksum="1685E110CB2801F8" modified="2019-05-08" version="1">MANVLLLRAPSQDGGDKYEDNIRTQGYTPVSVPVLETVLKNLPALKEIIQAGHSVKGYAGVIITSGRACEAWRTAVQELVSNSANTDWATVPFYVVGEATAKALEEIREAVGGSPFTPKDIRGRAESGTSERLAHFILDDLSSRTDSGKLLYLTGDKNRDTSPKILKEGGFDLEPLQVYETQGSSNFPADLQKALNSVPTGRWWIVYFAPSAAEFVTPTLRKHFDLRSIDSPPDTSRTIPSVAAIGPTTSTFLREQLSLHVRAVPSKPTPEALVAAIVAADSATSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYB6</accession>
    <name>A0A401GYB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein priB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1000360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617707.1">
        <property type="nucleotide sequence ID" value="XM_027761906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYB6"/>
    <dbReference type="STRING" id="139825.A0A401GYB6"/>
    <dbReference type="GeneID" id="38783711"/>
    <dbReference type="InParanoid" id="A0A401GYB6"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="694"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="768"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="794" mass="88876" checksum="6A6BC2595C62E0A9" modified="2019-05-08" version="1">MEKHQFTFQHPYGMSEPQTDHEEEHKEPAPKPRGARACMSCRRVKMKCVGGDDSIGKKCDRCERNGSDCVFEQHRRGRKPGAGLSESSKMLRRLEKGLPNAKSQLPQPDTSPQVSGAVLGKRSREELKGTDGDKEYIDEEGTDTQRKASYFKTILNPTEEGSCQLPGPSALLRLAPPTELPDPISAGLLDEATAETVLAQLFARLNPFIALFDPVLHTLPFLRARSPFLLSALLAAGCKFFRPGAHAAAAELAHAHAVRAFAEGAAGVEVAQAFVALTYWHEPADGRAWAYIGYACRMAVELGLNRPPAPPPHRETEREARERRNRGRTYLVLFVLDRSLSIQTGRQWMLPEGEFVRRAGAWLDETLLPVTREDVIVAACVELRRISGDTADALMMDQDARGGRVDCDILLRDSNERLNHWAKHWRGRMSLAGGEPFQFAFLRFFQLHVRLFLNSFGVQTALRSSSPARPNMQALDACYSSALETLEIVSKDFAQMRVLPYAQDNVTVMMTYSAIFLLELLRSPNTSRELEEGAAGKVHALIAETAQAYSDAAEFMPTSASAAHQAQFLRRLLLEHGQRDDTLRAEQRKRQCEEFNVPAHNSTTPYPQEYGAYRWQERDEVDGREMRSPYPVRAPPPETSAYRLPARRSVSPYRRSVERSASSLPCTPGPSSYYARCCTPKYAAYPRDMYEHTALPPPCPRRCPSDYAPRDIRAASPRPPRLPAPQYPTPSPDPPVPARRPTPEATERDVRYWRSMFRELGFGEGEDVEGPYCVRGRAREGREVGRVGSRGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYN7</accession>
    <name>A0A401GYN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1005250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618191.1">
        <property type="nucleotide sequence ID" value="XM_027762390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYN7"/>
    <dbReference type="FunCoup" id="A0A401GYN7">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYN7"/>
    <dbReference type="GeneID" id="38784195"/>
    <dbReference type="InParanoid" id="A0A401GYN7"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF10">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="534" mass="56157" checksum="70418D5B3C593EE1" modified="2019-05-08" version="1">MAFFRDTLFILSVCGVTMLNIFVHGALIIALPSLGRALQFKESELQWPLNVYALSQGSLLLLFGRIADVVGSKKMSLFGAGFVAVWSFATALSPNKVALIIFVALTGVGAAANTPTGISIFVSHFESGSATKNKAIAALGAGQSIGYVVGPIGGGILCQKVSLWRVIFYIQGGLAATFFVLGVLTIPPDPARARYTKGIDWIGACLSVSGFGLLTFVLSESTTVSRGWRTPWAPALLVVSLVVLLLFVAWEAHRERADRSVLMPVSILMKRGTKMAPMVGTIFLAWGGYNVTNYFVALYFDQVQGLDPLRTSLEILPSVIAVLAANAITGWLLSRVRGDVLIAGRFLISMAAPLALTLLDVHASYWASGFLVMVFVSWTDVAYTVGKLQISIAFGADSQGLAGGIFNVATRLGTSLALALSSSIATAVSDAYAARHPTVPGSAPAVLERGFRAAGWFAFALAAASSGICVVFLRGAGVIGRLAPRVSDAIEKEGGGTENEMGDVFGGAGKMLKGGEVLSEKSNDGEPQENYTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ48</accession>
    <name>A0A401GZ48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1101050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618342.1">
        <property type="nucleotide sequence ID" value="XM_027762541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ48"/>
    <dbReference type="STRING" id="139825.A0A401GZ48"/>
    <dbReference type="GeneID" id="38784346"/>
    <dbReference type="InParanoid" id="A0A401GZ48"/>
    <dbReference type="OrthoDB" id="3230070at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="8">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="144" mass="15905" checksum="96F149194067E15A" modified="2019-05-08" version="1">MKTTIRCKVGMGKKSEVYNAELVGLSWAACDATHYIQMTNPAINHLHFYADNTSTISTIFEPMSGPGQMHGRIFRQVITTFLNANPENTVEIAWTPGHKGITGNELADKLAKQATEIARGTTKATRAHALDRANEKAFEKWTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ82</accession>
    <name>A0A401GZ82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1101470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618384.1">
        <property type="nucleotide sequence ID" value="XM_027762583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ82"/>
    <dbReference type="GeneID" id="38784388"/>
    <dbReference type="InParanoid" id="A0A401GZ82"/>
    <dbReference type="OrthoDB" id="3197992at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="86" mass="9734" checksum="AC9902B02764DD4C" modified="2019-05-08" version="1">MCQAECFGNFHRKCQHYVKLYESGNKTDCGSPTCGLSSSHKHTARNCPCPKVRQEDRKVLNLIQDRCDACKTAAWASIELESGRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZS9</accession>
    <name>A0A401GZS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SAM50-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1103520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618588.1">
        <property type="nucleotide sequence ID" value="XM_027762787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZS9"/>
    <dbReference type="FunCoup" id="A0A401GZS9">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZS9"/>
    <dbReference type="GeneID" id="38784592"/>
    <dbReference type="InParanoid" id="A0A401GZS9"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="183"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="496" mass="53830" checksum="217946D11E99E57D" modified="2019-05-08" version="1">MEEELQAPPLKPPLANTSVPRDREPDRADLEKLRKWQEDRIARRLRGEYESAVFHLSELVNENLTTPLRIASVRVEGAVKTRKPFLGSIISPFLPTTSSPSVDGGSTLESVLRTTRHIGSLLQETDLFQSVEAKLEASQGILAQDGDVNIIFKTREKGRFYLNTSTEVGNNEGGASATCRVRNAFGGAETFEANLAFGTKTRVSFHGSLSAPLTPSLKTRGEISVFGLERDNSSYASSSEGVRGLRASVRTETVTSGLHEVAYEAVLRHISSLTPSASISMREAAGQTIKSAVSHSWTRDTRDDKLVGTTGSYFKLSQELAGLGGDSSFYKTEAQTQLSRPFVPGVTVSFAARSGLLWSFAPRSLFSDRFQLGGPVSVRMFRTNGMGPRDGPDSLGGDMYWSTGVSFISDVPRKPHWPVKLHTFVNAGRLDVVDRSQSLLDNVISSISKPSISAGVGLVYKLDPVRVEVNFGVPLVASKSDGLQRGFQVGIGLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZZ5</accession>
    <name>A0A401GZZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1103990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618635.1">
        <property type="nucleotide sequence ID" value="XM_027762834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZZ5"/>
    <dbReference type="STRING" id="139825.A0A401GZZ5"/>
    <dbReference type="GeneID" id="38784639"/>
    <dbReference type="InParanoid" id="A0A401GZZ5"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="903"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="903"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="956" mass="103670" checksum="55B14907C78047D0" modified="2019-05-08" version="1">MPSYDAAKQSEVLSPSDLLGSLENYTDVVSWINDIIDTGDAADETQPMKLTDLDQRVSRLVGTLEIASEDTSAQVERIIEEISRGASRLIHDLHFMREGALSLQGLLHEVDSKSKASSDAETSAALDRLHFLDTVRKNMEAARAVLREAESWGSLESDVTSLLSEKNYEKAAERLSEASKSMVVFANTPEYESRRTLMVSLQNQLEAALSSALVAAVTSQDVAVCRNYFAIFRNIQREAEFRNYYYGSRRGPLVETWQGARLRDCDGTAPADNNALAFSAFLTSFYTSFLSILQTERTSIPAIFPDPQPTLSALITSTLSALQPSFSERLSALATYYGPATLTQLIAAFRATEEFGVTAEKIFEKIGYSAILANSDNSSQPRTRLRRRSSVRMSMSMSQRPGSHRGSISGVVPTEAVPAVTIPVLEWDQELFAPFADFQADYGLLERRFLDDVLANAMRTAPRASSDRARILRERSVDVFGAAEDALGRYAAFTHGYGAEGLLQAVDHLVSAFADASRAEIAGRRGAFGTSGSLTPSLSGEDFSDMDYAAEDWAEIQALLHLLEAVRALQDRTLAFETKLRSSLIQVSGTLRAARTEPGTLQISGTTRGAMQLLAQSSLNSASLHVLLDSVDPESASQPQFRSDALLAPAPPSPDPRRSSYALPLPSPPASAPPLLNGARTAIAELAKACQVALQDTILSPLHKHLASYASSPLWSSASDTRPKRATTGSAVSEVQVPTFSRSSSETIQRVAEGLLNLPRLFEVYADDDALAFSLSTLPHIGPVFLRALAEPVPQEPSGSPSMQHTRRSPSLALQKNPLVAAPAQASLRFLPEAVTAVWLASLGRTLLAHLTGDVLPSIRMLTPAGAAQLAADLGYLGNIAEALNVEWLPLSRWRMFVEMEDADGRKKTKDSGKSQVGDKVRDGEKVAEETDDEDDEGESEDQVLATVAKLRGWPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0K7</accession>
    <name>A0A401H0K7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1201690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618856.1">
        <property type="nucleotide sequence ID" value="XM_027763055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0K7"/>
    <dbReference type="GeneID" id="38784860"/>
    <dbReference type="InParanoid" id="A0A401H0K7"/>
    <dbReference type="OrthoDB" id="2803003at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="3">
        <location>
            <begin position="370"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="576" mass="62535" checksum="027943BD5F855040" modified="2019-05-08" version="1">MSYSTRSCKFTATAQPNYRILAGIQTEGQKPRRTPTEAANDREQAGVRRLEIQAKQRALAQRIAELEREMKNEDEHYATEVARTPASLKAITSEHRAVVAGGSSIPLQTDDGNAGREEDDAPLVAKAKPGKVKKLTRTDVDAAHKVLEANATSGPASVLARGEENMPPVAASGGLVRPSKRKEVPAMSSESHASKKLKPAHPTGVRNTWTPKPVKPPHKSKSKFAKAASAPSGTGIVINAGGGGLQDSGDENGDVERAALHGSGARAQGRHTSNGIVHIDLTQSQETQLADDPVEAVARRGNSSKRFTNSDLPIPLGLLWKWRLQLIPRYLEKIGESACNPWNVVGLDLVAMLQQLWDEIFPDIPIIVTPREAVYDVAQQRVRDWRHKIAEAGVAAVANFFVLQAKNGGVETEEEIAEYVKWALGSGMPFRYAGATMKGPDGKVPLPDSKGPFQSEFVLRTLGAHFACTNRCSEIAGIPDAALALCITSVERALKRWESGSIADVPEPKFSQETYGRITNYYLNSVCNLREATWAKIIEGGERWRCTFRLLPGDFSDSEWEAGADGERGAIEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0P0</accession>
    <name>A0A401H0P0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1201990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618886.1">
        <property type="nucleotide sequence ID" value="XM_027763085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0P0"/>
    <dbReference type="STRING" id="139825.A0A401H0P0"/>
    <dbReference type="GeneID" id="38784890"/>
    <dbReference type="InParanoid" id="A0A401H0P0"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="376" mass="43451" checksum="E1B4ACC18CC4FD2C" modified="2019-05-08" version="1">MNVAPHKLPSYALCSPERAQFYAEKTRDGHYALLESETFWRDRCIFLQQHGYQLRPRYHPNWSPSWLGTTFDPTFCEDSILLLTDNVIDAVRLQDGELVSIKAVPEHSDEIRIARFLSSPELLEHPTNHSVPVLHVLSDPLDNQFKLMVMPFLRPFNNPPFYAIGEVIDFIQQTLEGLHFLHTQGIAHRDCASANIMMDARSLYSQGHHPVRLNYSREGIYPVYPLSRMNHHVKYYYIDFGISSQFQEGNSPYVTGRKGRDKELPELSFGVPYSAFKVDIFTLGNLYTKEFLQKYLGLEFLDPLVAAMTDRRPDQRPTAEGALLIFEGIRQRLNTAFLRWRLRARDESTQERVVYDAVAAAREGLYRLTHLISSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H166</accession>
    <name>A0A401H166_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619055.1">
        <property type="nucleotide sequence ID" value="XM_027763254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H166"/>
    <dbReference type="STRING" id="139825.A0A401H166"/>
    <dbReference type="GeneID" id="38785059"/>
    <dbReference type="InParanoid" id="A0A401H166"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="171" mass="18564" checksum="03C9DDBAB9252374" modified="2019-05-08" version="1">MLRFNNTPSSMQISLLKYRASSRSTKRRRSLCLATAGLVLFYPENPQASAGFFPPWREGGRGKYAGHPIAIFGGSSSVGQFDTQNATYQVLAPHGKLLLVLGDQVDPALKANGGDKKINVFGNTNVPANRQAGQYLYGQLTALLEGGAIEVHVCHLGWRIEVDASLWCSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H186</accession>
    <name>A0A401H186_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vacuolar membrane amino acid uptake transporter fnx2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1204090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619091.1">
        <property type="nucleotide sequence ID" value="XM_027763290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H186"/>
    <dbReference type="FunCoup" id="A0A401H186">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H186"/>
    <dbReference type="GeneID" id="38785095"/>
    <dbReference type="InParanoid" id="A0A401H186"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE88178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="583" mass="60504" checksum="CFC9C8C23060680F" modified="2019-05-08" version="1">MADEATPLLRDPDSKDDQIVAYTEPIEANASSRASEVGDPEGSPAEEEVLKPKASIRAVMVPMMLGIFLVAMDQTIVTATYASIGSQFESLQNTSWIATGYMLTLTSFQPLYGKLSDIFGRKACLIFAYAVFALGSLFCGLARSMPQLIVARAVAGIGGGGMSTVATIIMSDVVPLRKRGTWQGIANIAFASGSATGAPLGGVLADTIGWRWAFLLQVPLTVLAILSVALGLRLPRADNAAFRAKLRRVDFGGAFTLVLAVFALLLALDRGANAAWRAPLTLCAFAVSALAFALFALVETRVAAEPLAPRHIVASGALLASYLCNLLVNGVFFVITFHVPLFLQAVRGLGAARAGAALIPCIAGGVSASVLSGLVMQATGRYYWLTVGAFGVTLAGAVLVALEAGAVGFDMVWLCVGLFAMNFGGGASLTTTLIALIANAGPADQAVATAVSYLFRSLGSVVFLSLGTTLSQEVLRARLRAGLSGADVDEIIEHVRASLAYVGELPPAVRAVVREAYAAGVQAALWFAVGLAGLGLDHPDQDQLDNVGTLTISSFSSSAGGAPSSSDMVGYGDRGRDEFSARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1L7</accession>
    <name>A0A401H1L7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619227.1">
        <property type="nucleotide sequence ID" value="XM_027763426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1L7"/>
    <dbReference type="GeneID" id="38785231"/>
    <dbReference type="InParanoid" id="A0A401H1L7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="122" mass="13109" checksum="1528EB8E6AF8DFCD" modified="2019-05-08" version="1">MSITQPTPISHTGQLGPISTTHPTASSLTVTDVAQTSDITSTAECTNTRGPKRALIDIELTDSGCKKASKKNPLVYEGHHFGRTVEMFTLITIIINEGVACEQAAGAELIYSEEQAYIFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H215</accession>
    <name>A0A401H215_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1302470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619345.1">
        <property type="nucleotide sequence ID" value="XM_027763544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H215"/>
    <dbReference type="STRING" id="139825.A0A401H215"/>
    <dbReference type="GeneID" id="38785349"/>
    <dbReference type="InParanoid" id="A0A401H215"/>
    <dbReference type="OrthoDB" id="2563978at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="863" mass="90093" checksum="E4752E0CD32F4B1A" modified="2019-05-08" version="1">MSGPTQVLPSWLTLSTTVITQPDGSVSTSSATLQLPLTYYGPSIPLGTDGSWTWGGLTPPSSATTAPPTASSFSSSSTALLTSSVPATSLALSTSSYTSTPLTSASSPSSSSSSVSPSASSVTTSHSTHLSRSAIVGAAVGGALGFILLLIVVFTFWCLHRRRVRSAADPSTQGSSSFWNRQTTLLSRVGSRRQTPIWTGWEVLDPDPDEAVNDEAARSPGEGSPRGSGEEDDPFLTRRSVASGPDEMTQAKTGTVALVSLPAAAAVPGGASPTRSEPRAGGPILSREALLRMDKEDALPEVRVIEASPHATPLMPPPPLGRGLRSAHNPSIRSIASNVTAGSAQNRSVASEPSMGSFSDPQEHESAELLTARRVNVGDLRQARSTELPRLGSEEAGSSALDRLTNIGRLSWFRRMSFLGAGAVAAHGPRSPSTPPDTYTRTPPRSHSRSHSRPVSWAPLPTHDPTGAELSLGRARHDSPSLGHSIETDERPISTLSTKSGNTLYLDARSTLGSSEVDLASVGTGSANAPPPVPPIPPVSEQRQPSSPLAREIRRSDNSGAYPGKPPSYDVIALSSGSPPEPVDILDIPAPPPAEPFAAARHDFPPGLVPLPSPRVWRDSQPSSPTSGSSAGIQIDVLEEEPPSARAGWRSLQGSGEENRRTTFGIPVVVHARDAQNSEQGSLYSMRSHLSPRSRLSPSGSAPASSLHTVSHSGSGSSSRPTFHSQGRAAGSGVSLSHSNSVSSDERRPHRRAAAGEVGSPPLSAVWPGRNYVAQNHPPILPQGPTPPPLAYPSPLFGRPAVSDTVTSSGTSRTTRTEDTNTSSVTTAMTDPITGAVIHSVRLPWRGGDSAWRDSAHEDDPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2I4</accession>
    <name>A0A401H2I4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear pore complex protein NUP96 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1400230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619531.1">
        <property type="nucleotide sequence ID" value="XM_027763730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2I4"/>
    <dbReference type="STRING" id="139825.A0A401H2I4"/>
    <dbReference type="GeneID" id="38785535"/>
    <dbReference type="InParanoid" id="A0A401H2I4"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore complex protein NUP96 C-terminal" evidence="2">
        <location>
            <begin position="379"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="877" mass="96235" checksum="03697CE6E8B4665C" modified="2019-05-08" version="1">MRFRAYTTDSEDEEDDHLSVSSVSADELPPAPTDMDEDARSESEGSIHEDELMPTVASRKSSRALQSISEDEDMSDSEAAPSKNPPRKSMPRGPMNDPTLIPWARQLGVDAQKMHVMQTSLFRVPEEEAAMRQQAQTLARRKHLLSATLQRKHSRDSEGEGLRADSRQRASFAHDVEPTPFRPTRKYSRVDGSSSAVSGSEGLVADAGLAFGRSFRVGWGPGGTLVHLGQLCGPNSTPKGTANTSVVQKTVVPLFSVPATEASELASRLLSHHLEYTAIQADADGVPFANPRRTMSFASLMTRFPSTERSFEACLFRLGHALFDPISLRLADSITADVRPRISTIRRKAALSQWLQEAISSSIDADLRDNPGADWAHVVFMLLTGNQVDRACEVAMEGGNVKLASLIAQYPGDEEFRDDLLSQLALWRDERVDAHISENVRKVYALLAGIVDTLEGSKGTGVEQCPDINLAEGLSWKRAFGLHLWFGQPLEASVADAFQSYDASWKEPTSVVSAPVPWYAEEAQQESRSSPWKLPSSANPPDALFSLIRLFADPVCSLSTILTPFSFSASPIDYRLAWHLYIVMSRCLRVRDFADRGLPGGDVLTEMVGDDDEPIEGHSPSADLLANSYALQLEQMGMIQEAVFVLLHIEGSAGRARAVKALLGRCAGKLDDWTTRGLVGSLKLPMAWVHEAKAVYALDNNDVFGAYELYIGAGLYNAAHELAVLALAPDAVIHQDFALLNEIFKKFIGHPVDGWHVRGKAFMDYAHAMTRLPVLRARLADAGAAADAADASELEQLAHSVPKLIGILPDVLRDRSDTRHKAALAEMTAELTRRLDEVKPFAIHQSQIRSPFMSEGIRQRNIQMAALERFVRSIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H317</accession>
    <name>A0A401H317_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">SCP_1401970</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619705.1">
        <property type="nucleotide sequence ID" value="XM_027763904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H317"/>
    <dbReference type="STRING" id="139825.A0A401H317"/>
    <dbReference type="GeneID" id="38785709"/>
    <dbReference type="InParanoid" id="A0A401H317"/>
    <dbReference type="OrthoDB" id="2783063at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="508"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="752"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="780"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GBE88792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1082" mass="121130" checksum="E14819C8B3940D1C" modified="2019-05-08" version="1">MSLYPPISQASSKAESKCLYDVPFLESNGGNFQTWKYRTTTILRLRGLYSLIDGTEADPGTVDTMKKVEWDVRNNEALAQITLTLKDEPLNGVMYSMTAQDAWEKLNRRYEGRGKQTLAYLISDLFHSTLSDESPLKPQLNTMQQKAHILETLGLTLDDTLITIAMAISLPPSYSTLRTILMASDSKLTVEKVVNEVLSEEKRRGEMTAASALIAKHADTKSKSKGKDKDKKKKGKCAFCGYTGHTKDECRKFKASQVEGATAKGDKKAEKAADAKESAKIASVGEADSEMLRLFVAKELARGDDLHRWIVDSGASSHMTSHREWFVNYRALATPKRVYLGDERFILAVGIGQVTLRAAVDHGSTNTGIFDRNSYDVRFADGTCRISNAQGRLSAIGYMRRNLYVLDVTTQLPERTYILQAKDLPPSYDDSMDDPPLHAFVAKETTSSASAQVWHRHLGHISVDSVLKIVRKGMVKGMSIVGEKVSNVSCKPCLHGKQTRQPILKESDVKNPRILHRTYSDVCGPMQTQTQSGHHYFITFIDGHTHHLVANLMKTKDEALSHFKAFVERAEVETGQHANILRTDGGGEYESKEFEAYLKEKGIHHEKTNAYTPQENGVSERMNRTIEEMARSMLNDAGLPNTYWGDAVLHAVHILNSVPTRTLPDNLTPHEAYTGNKPSMAHLRVFGCKAYVHVPKEKRQKLDSKMFECMHLGFAANRKAYRLVHRVTGRIVESRDVYFDEGTEVAPSRVTIDVTPTQEAPDARPQLLPSPRPPRPTVEDVPDEDEDTPALLDVDDSDDEDDDDNADEDSDDDVPLPEITRCAATTTSSPGSRTAPFRSNAHGTDSENAEEVGDAENAHKATSWDEPQTYEEAMSRPDAARWKAACAEELHAFVKAELYDEVERPQNRKVIDCKWVFKIKRGPDGEIEKYKARLVAKGFTQVEGLDFNETFAPVAKFASVRTLLALAAKLDLEIHQMDVKSAFLNGDLDEEIYMKVPPGFRRSNSLVWKLNKALYGLKQAGREWYKKIRAEFEALGFTRCHSDHSVCYAAVKHERQVEFVTRQGLSLRHKSVQVTLLAMSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H365</accession>
    <name>A0A401H365_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1402510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619756.1">
        <property type="nucleotide sequence ID" value="XM_027763955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H365"/>
    <dbReference type="GeneID" id="38785760"/>
    <dbReference type="InParanoid" id="A0A401H365"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="179" mass="19378" checksum="7DF5DEF55F01723E" modified="2019-05-08" version="1">MHDTHRSPSLSTFLCSSDYFTPVFNPSQSGLEESELGNTLQNDTNGILKTSRVSTALLVHCMTPLDNSAHMVNPDSLQDANSDDAKCTKYAQCPRPVYLYNAFPSESNALGVVMETHTGDTGGKDEQVDTGCEDAVAVLDTYRLTLLVEHAIFAIDDNTILGGPHVFADTTLTCAQVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3J4</accession>
    <name>A0A401H3J4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1500170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619928.1">
        <property type="nucleotide sequence ID" value="XM_027764127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3J4"/>
    <dbReference type="STRING" id="139825.A0A401H3J4"/>
    <dbReference type="GeneID" id="38785932"/>
    <dbReference type="InParanoid" id="A0A401H3J4"/>
    <dbReference type="OrthoDB" id="2782214at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="400"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="447" mass="49676" checksum="FDDD0970EBB016A9" modified="2019-05-08" version="1">MDHNSIESKSGGGGANSEQTIVFPAVHPRSTHPHITPVDRQHQSRLASDDSSLSISLYGYNDQYLAKESSNCTPTLDPNDAQPEAIFSSDNLCSSVALQGSNAAELKVEESNFRVTYPDLQGFDAQAPLYEPRLAQVPPHVPQSSRYPHYSSTVHESKPELDRVDRCSRWGTTSLPPTAGRYTGEWGPMEASPPFYQSATPSQFEHATLPASSGHLHGDNYQSLPEVGSSSSLHNPHLPFPQARTNTYPSALSSPMHPVHYTQPHASDAYGGASQLPYHPRYANHAHGAQPYPHDHYRNGTYALVSEKPPVTYEHPEPPPRDYFCQWVTDNRGTVCNILLDDVTPSGITRHLREHHFPSSEWNKSYRGICRWGGCTRSEMDYASFGKHIASVHLRGAVLWECEYCTRDFSRRDAMKRHLKTCPRSPTSEKNAGPSRRAGRHSSSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3J8</accession>
    <name>A0A401H3J8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619895.1">
        <property type="nucleotide sequence ID" value="XM_027764094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3J8"/>
    <dbReference type="GeneID" id="38785899"/>
    <dbReference type="InParanoid" id="A0A401H3J8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="150" mass="16509" checksum="B57991D29F40AAF7" modified="2019-05-08" version="1">MNSTTFQNLNVGATAALQTRRQGTPRGNQREAPRILEFHCFSDPRSSSPAAAAQNQCKPFPAAKFTVPRETEELQTVGPLVWDETIGMLTIAKGNAMMVHVLDLAESPTFEAEQDLYVFEHPNVDIFDRPYSRKAHETSDAGSGSADEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3X7</accession>
    <name>A0A401H3X7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1500920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620002.1">
        <property type="nucleotide sequence ID" value="XM_027764201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3X7"/>
    <dbReference type="STRING" id="139825.A0A401H3X7"/>
    <dbReference type="GeneID" id="38786006"/>
    <dbReference type="InParanoid" id="A0A401H3X7"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="369" mass="40290" checksum="CE885AE9FF240A42" modified="2019-05-08" version="1">MSMDTVRNVVVIGAGVIGLTTALKIQEKGGYKVTVIAETFPSDPKSVRYTSPWAGAHHVSHAAADVQQRKIDEETFKVMWDLSAPGGDAEGCFLRIKEKEWFYDGRNTHLDWMPDFQQLPEDPLLPNARIVSFTTFTIDTPAYLNYLLSRFLARGGNVVRSTVQHISQIVEGGAQVFARGRASPTPVDALVVCPGLGARTLGGVEDKNVFPIRGQLVVLRAPWVNFGRTASHEKQGVWTYIVPRRSGDVIIGGTKVDNDWYPVARPETTQDILTRCLALCPELAPAHVRAERAPTVEDLYPLIQEEGCGFRPARAGGIRLGVEWVDTPGKKGKIPVVFNYGHGGGGYQSSWGSASVALDLLEKALVGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H421</accession>
    <name>A0A401H421_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1501860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620091.1">
        <property type="nucleotide sequence ID" value="XM_027764290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H421"/>
    <dbReference type="STRING" id="139825.A0A401H421"/>
    <dbReference type="GeneID" id="38786095"/>
    <dbReference type="InParanoid" id="A0A401H421"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="5">
        <location>
            <begin position="283"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="5">
        <location>
            <begin position="384"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE89178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="501" mass="56139" checksum="9AC48A2867297996" modified="2019-05-08" version="1">MQVSWCKVEATVSDPKDVNAFSDTDIQFPKETPPLTVMSLGLNTVVNHKENNREIVCATARIWSNLQIDDPTPPEALPCSVHTFVPPLDRFPPNFENEWMLLNSLLDPDVIVGHEFLGVALDDLIHRMRELQGSNLRFINGRLVCDLASDGAKGMISSTTWSLTEMCKTHLKSERQDIDPMILPATSTVACLLLDGAGGQGTDASFDEATDEFGWKLMEQDAQRWTCREKRVYGKMAATVEKIEARDIDAEGGKTTKGKRDKSSNPSEYNIDFMIVDRMEDEEGEEKIPESLSPEVAQGVLPRPIATLVNRRRQAKSLMKDRKATQSQLLQWDIKQMALKLTANSTCGCLGFEYSRFYALPSLPPRRSRVVVYGDTDSVFSPKKAVNGRYKLLEIDLDGIFQRLLLLQEKKYAAIKVEDGGRPSTEVKGLDMKRRGYCALSKAVSQYVPDQILSGEATETVVERIHEYLTTMGEDIRAGKIKLDEFIIPEDHPNAKSQPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4C3</accession>
    <name>A0A401H4C3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620209.1">
        <property type="nucleotide sequence ID" value="XM_027764408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4C3"/>
    <dbReference type="GeneID" id="38786213"/>
    <dbReference type="InParanoid" id="A0A401H4C3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="100" mass="11173" checksum="6210243FDFC6E8EC" modified="2019-05-08" version="1">MDHLSHPQQITLAPSADYLLDLAFTFVEIALVILTTTMVDIPSPVYNLAIMLSRTAVQPALAALSKFWMTHVLHRVARSKMVPPSKLMKVAAAFEVDLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4G9</accession>
    <name>A0A401H4G9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1503360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620241.1">
        <property type="nucleotide sequence ID" value="XM_027764440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4G9"/>
    <dbReference type="STRING" id="139825.A0A401H4G9"/>
    <dbReference type="GeneID" id="38786245"/>
    <dbReference type="InParanoid" id="A0A401H4G9"/>
    <dbReference type="OrthoDB" id="3027208at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="344" mass="39456" checksum="D8D7825A526D7785" modified="2019-05-08" version="1">MLTDFQILLGFLICVCLLYRFRHLFTDDEPPPEPSDITVNKEFWKYGGDVFLDAQNSTRFRVHKDVLIRNSDVFRTDLQVLDSRRADADIVDGCPVLYVADYPDDLIYLLRVFYDDRANRMASRGLCVLMEVEALTRMAIKYQVADVRNDCVSRMRSFFTDQFADWDKHMSHGGLRSDSIRLEAQNEAISAVNLARLTGQHSMLPTALLLCCDIPQDELAAGVRLRNGRLDRLSPEDLKKCEEGRKTIKKAHLVGRGQICHFGTAGSDCPRKTCAEVLAGWLSTDRIALERCSDQFNLAEHELCDYYKLCEQCSVTVRASIIDYRRAFWKMLPSFFKLGDWPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6B8</accession>
    <name>A0A401H6B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1702900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620877.1">
        <property type="nucleotide sequence ID" value="XM_027765076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6B8"/>
    <dbReference type="STRING" id="139825.A0A401H6B8"/>
    <dbReference type="GeneID" id="38786881"/>
    <dbReference type="InParanoid" id="A0A401H6B8"/>
    <dbReference type="OrthoDB" id="2794748at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="184" mass="21727" checksum="DCA3E3033BD6A26E" modified="2019-05-08" version="1">MRSEQNRRQYIAHEEYYPTPFTKPLPNVLCIFMEYARQDFPLCFRSVVAESPNLGLWTHPYTFKAPNNTWSLRVLHGVVKQIHTFQWNELVRQGQEQYYESWRDDTRWDASAAGAREELCMRMAAWRSASENVRGNVLGDIYLEWGAKIICCLSKELDVRCKGVSAYDEEHHDGKLPFQRMNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6C6</accession>
    <name>A0A401H6C6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 1, mitochondrial</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 1 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD1</name>
        <name evidence="14" type="ORF">SCP_1702490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 alpha chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="12">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase 1 beta chain</molecule>
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6C6"/>
    <dbReference type="FunCoup" id="A0A401H6C6">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6C6"/>
    <dbReference type="InParanoid" id="A0A401H6C6"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023500302" description="Phosphatidylserine decarboxylase 1 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023500301" description="Phosphatidylserine decarboxylase 1 alpha chain" evidence="12">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="12">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="12">
        <location>
            <begin position="93"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="479"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE89923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="521" mass="58107" checksum="F10BF99A25321E55" modified="2019-05-08" version="1">MLRGRVRKNISLHSWRFLERCKRSRITVFVRRAHRSYSTFKQPQQESNSGSQRPPLRQRLASAWKETPTTWYPLPVAVGALLLLAIQFRKKVAETEVHVDNEGREVVKLKGPWHVHVMGALPLRNLSRVWGYVNSFELPVWFRPYGFRFYAWAFGCDLTEIEPEDLTKYASLGEFFYRDLKDGARPVADAVLVSPADGKILHFGTITNGRVEQVKGSTYSLDALLGVESPHVRPAPVTFPRRDMAEVDDRDFADINGIEYSLEELLGASESNTPGSSGTSTPTTSVSPGVHPSHAKKYGAQIDASVSFDASMSDVIAHDASVAAEMGLRPSLERTRSRLSKAPRPGNALYFVVVYLAPGDYHKFHSPTAWVVEKRRHFVGDLFSVSPWMAKRLENLFVLNERVALLGRWKYGFFSMVPVGATNVGSIKIDFDQALRTNVASRRRPPVGTYTEAVYSAASPILNGQPLMKAQKMGGFSLGSTVVVVFEAPQDFQFTIHAGQKIKVGETMGDVATAFESKKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6H1</accession>
    <name>A0A401H6H1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SRP-independent targeting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1800360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620927.1">
        <property type="nucleotide sequence ID" value="XM_027765126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6H1"/>
    <dbReference type="STRING" id="139825.A0A401H6H1"/>
    <dbReference type="GeneID" id="38786931"/>
    <dbReference type="InParanoid" id="A0A401H6H1"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="184" mass="20519" checksum="F001557DF95ACE72" modified="2019-05-08" version="1">MNAAMSNLVISLGAMQVARKIPFDDPQVLLYARIGYVAAQVIILAVYYYVSMKIKEKNDLTVLKYVEPANPMAKDDNNLVTTTVRDYDLTETSKLVRGVYIGFAMMCFLHLYMKFTQPLFVQALMGMKNLYDAKPVAIYILGKAAEGDLKRPFKAGGMFGAAADPQTDKAAIDEAEKRRGKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6L9</accession>
    <name>A0A401H6L9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620944.1">
        <property type="nucleotide sequence ID" value="XM_027765143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6L9"/>
    <dbReference type="STRING" id="139825.A0A401H6L9"/>
    <dbReference type="GeneID" id="38786948"/>
    <dbReference type="InParanoid" id="A0A401H6L9"/>
    <dbReference type="OrthoDB" id="3236156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="320" mass="35853" checksum="16153B6EE561799E" modified="2019-05-08" version="1">MALRKKELHDENTNRRFPDTSNTRYQAYSYGACELVVYHHLYVELMEEICDSKAKPGVNHLESNVAKGLQDASTLAELAAMALYGVSVLWPYLSQARGDGSKIVNLLDLTELHRKLPTFCNHIALHPTLLLDSNAPLDEVTLNGKPFMDKMLLAAVCMLAPDLPGLTCMISAMFSGAAKGWVQFTTEFTVGGPFDSLTSAERALVFIPSTNNANEGALGSWRVHARSRPSSTASTFSSQARSEHNNTEEFIVKCCNEDDQGYVMRTVRTADASGENAQFREELMENQWEHAVQYRKKQEEDQRKKDREKERLRSIGLITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6Q1</accession>
    <name>A0A401H6Q1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1800620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620953.1">
        <property type="nucleotide sequence ID" value="XM_027765152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6Q1"/>
    <dbReference type="STRING" id="139825.A0A401H6Q1"/>
    <dbReference type="GeneID" id="38786957"/>
    <dbReference type="InParanoid" id="A0A401H6Q1"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="201"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="785" mass="89858" checksum="70DBFF45D06CFBD0" modified="2019-05-08" version="1">MSNSRSHAPSPSTLPAEADLSLPPTPHSVTSDWTPLAGEENAEPKNPRRSDDDNELHAEKAEGFILGPMPVEDFLNFLPAKHTARRPSTEGAFNNVDEPDVAFQLLAAIGGHDRCPGFEFKYNVLDSTSIKPALVCVPKDSIGSDNEATAKYAAELFIDVQSSDQGDFFRDPKPFADRQRHKFVLTPQDAEKTNRVKALQAMGRNIRWATDALMHQHRVHYFSVSIHGLRARLMRWDMSGLIASESFSLREKPEVLCEFLWRFAHASTVERGYDPTVERASSSEECLFRRLVSCHVREQLDLKLVDIPEEEVKVEVREEYKEQCALLEKTVGQHYEAGRVAALTICAEDGRFKRCLVSRPIATNFSMRRGAMRGYWAVMDGRVVFLKDTWRQYVLEPEGRILKELEAHGVKNIPHVEHDGDVPKVMYCDGMLTRFSAMANFERTTRSKAGQQPSFQCTETDLYREAEWLCHGGARIVVHPRVHHRLVLKEVGFPLQTLRGTKELLEATHDAFQDFSGDLALIAAHDNARRIHRDISAGNVMFYRKPYEDHRTGYLIDWELSSKVQEDGQATDKYIVGTRIFLSQRLEARSQRRHMLQDDMEALLYVVAYCGLHWLQHPAHSKDMRQVVQAMFHNRKEVHAGDVPEITHTTFQTMEPGKGKLDIKENQTYIDLPNFNADLKDWLSHSMDLNHPRDPNEATQWDTPEPWNDYWKEFLERELPEDDRIRKQDSSSMRPKFAVKAICHRAGIHPNKRKTPQRRGPTDDGHANDAPGNGRPVKRLRRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Z2</accession>
    <name>A0A401G4Z2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PhoX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0101050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608146.1">
        <property type="nucleotide sequence ID" value="XM_027752345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Z2"/>
    <dbReference type="FunCoup" id="A0A401G4Z2">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G4Z2"/>
    <dbReference type="GeneID" id="38774150"/>
    <dbReference type="InParanoid" id="A0A401G4Z2"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="111"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="859"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1232" mass="137483" checksum="7EAC6CC907FD9CE2" modified="2019-05-08" version="1">MLSKLVFSKQTAVIVLLLGLVWPAAIRVLSSPVTIILLLPVFALLAAVTFLGLNLLFGYALDATRPAVHNALPAAARPLAFSTPAAWQAVLTRSQWTYKSPQSLAPLYPESPAISSALNDILIMIVRDFVLVWYKELSSSPSFPTAVSSILHSSIEQLLARLATLDLPAFIVRRILPKVTAHIEQFRQSEVALRGAGLERRLTQSEELDLLLASRYAGRGGGKLHPAVDNLSSTFTRQTEENHLRGLIDKALPSILPEKEARSHAIKVVVREILACSVFYPVMDMLADPDYWNRSIDQIAGAAIRQQKLVSKVRNILEAQLPRPHSRVPGRGPSTTETITIRTDPRQFESFLRSINRCSSLLDARRLKNDVMGEIRRTRTLLANHENEDWINGQKTEDIVAFLDRLYTAKRRVEKRIVVLGGESDTRQSVYQDADRTTSRLALRDILTNPSSLSYFMEFMDRRHRSLLVQFWLTVESFKNPLESVDSGSSDEDDAVLDPSPSATLKEDISMMNELYFSNANLDPALAFISQKHVNTIRSFGIDTEAPTPTAERKVRRSVLLAQRQVEQDMEQDFEDFQRSELWFRVIGDIEANGLKSDDQPPLSRTSSEIAQAPWRSVRDRSRTGLARSESSPLLTSTHHPARSAPSLLMGPEDSLPRSSATNLELLVSPVHDSPSPSSSRAPLFDEPEEGSLPGLNEEAQRIEAIQAALTDIIALDNQHDEPQGRGSADALSLQGSGMNVSRISEDGKRRRVFDDDIDDEEDRPDDDNEKPHGSFQLAGPGDLHLSHEIARLASKIANSQSQDFMLDSLIKKAELTGDAQELRLLRRSKSTLTRELRELTFQKTQYEQQESANRLLSDRTKVAIVNSTMSEEDSKSVVRYLIEIQQLAQDGSFTSGWVVARRYSEFLSMHNKLRERYALVRNLDFPGKRLVTSLSGSFIDTRRIALEKYMQSLIAIAAVCESDELRVFLSRDSPFIASDSASQSSKSPTAFPGKDLVRTMYHSVAESIDDMFFGPSMLDVMIQRLTTQAAEFAGIVGTGVHDEDLVAQALKATGKSTSEEAILQLSGDLKPLEGETSSSMFSSPICDLVLAVFELDKKNNWLRRQAIVIILQQVLGGTIERKIRETIKSTLDQPHLMTFINMFRDGFWAGGQLKPAGIPRSAEEKLHTRDEANRKLSALMPDLVANMIGRSNARRGARRIFAVLQNRRLNQHLLYTIADEIFATVFSESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5A7</accession>
    <name>A0A401G5A7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0102160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608256.1">
        <property type="nucleotide sequence ID" value="XM_027752455.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5A7"/>
    <dbReference type="GeneID" id="38774260"/>
    <dbReference type="InParanoid" id="A0A401G5A7"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="100"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1321" mass="146601" checksum="E85DD34B68E63092" modified="2019-05-08" version="1">MAITHQVLTSPVSGTKVYPVREYSDEQKDMIKALREYADTLLLPESDPYHAWELRWLDKPDTIPRYIRAAKWKFEDGKKRIKSTMEWRRDYKPDLIPPDEVKIECETGKIILNGFDKDGRPILYLRPGRENTATSPRQLRHLVWCLERAKDFMPPGQDSLVIIVDYKSTTLRTNPSISVASKVLTILQQHYVETLGRALVVNLPVILSFFYTGISPFLDPLTRDKMRFNPDLLELIPKEQLDADFGGDFEYEFEPESYWEQIVSFCGIAPDGTRVHNPVSASAPSVQEQPVDAGKHYRRSVETQFKRRVSTDVVEAIPNEEVAGTLILCTQLNFAMDFVEMESLVSLISTSIAQLKDRANTASSPENATRAEFLRPSLQIVAAASQLIALVRTPERYLMDVANGHVLSECLRTTVDVNVPEIIREFGKGPQRTLHVTEIGAVNHVNPSKLGRVLRLLSTHHIFEEVSPNVFANNHISIALDTGKSLSELEAQPAEKYDGTNGVAAIVGLLTDDALQNATYLSDTLRDPATTDSFDAYDAPFSRAWAKGAHLNMFEWLNLPDNVSRRKRYQMAMNGLNKMTPPDSILRGFDWTSLPEGSIVIDCGGGIGSASLPVIKACRQVRLIIQDTEKVIVEAPAFWQTVLPGAVAEGRVSFQAHNLFYPQPPNNSEAAVFLLRMILHGWPDTECIRILNHIRDCIGESMEARVLIVDNIMLYASRDAATVEPDLLAPEPLLANWGTANLHSYTQDVLMLCNHNASLKCIKLIKAGYLRLSLLPYNEDARPMMLERSSFGHVHEASYAPQKLSTASTTHSESVPQPGTFIRSGHRRYLEGVISRAVGAIPQPFTFNTRFKFVQARLAAMDVVKIEALVSLLSTSVTQLKKHQDPSSNAEFLDPSLQIVAAASQLVALVRTPERYLLDLASGHLLCACLRTVVETNVPEIIREFGKGPRHSLDVSEIGALNQVNPSKIARVLRLLATHHVFEEVSPNIFANNTISIAMDTGKLLSDLKANPIEKYDGTDGVAALVGLLSDDSARNSGCLSDTLKDPATTNSFDPYDAAFSRAWVGGDHLNMYDFLDLPENLPRRKRFQMAMNGINKLTPPNSILRGFDWSRLPSGSIVIDCGGGIGSASLPIVQANPQIHLVVQDMETVVAEAQSFWQTVFPSALVEGRVSFQAQNLLSPQPSSNHQTAVYLLRMVLHTWPDAGCIQILDHLRQCIGDNMAARVVIVDNVILYACRDQTVNGYDGGLFDAGALAPEPLLANWGTANSHSYKMDVNMLGNHNACERTLPDFAALFAQTRFRIVEVHQAHKSWLPQIVAAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5I5</accession>
    <name>A0A401G5I5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldehyde dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0102900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608330.1">
        <property type="nucleotide sequence ID" value="XM_027752529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5I5"/>
    <dbReference type="FunCoup" id="A0A401G5I5">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5I5"/>
    <dbReference type="GeneID" id="38774334"/>
    <dbReference type="InParanoid" id="A0A401G5I5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="84"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="613" mass="68332" checksum="2B508ACC241FDE54" modified="2019-05-08" version="1">MGYDHDDEGGMDVLYLVTITFALGIYLVVWRFQTIHNRAVPFFVRSPDQIGPNFQGLSVVRPDLEAHLRHEELMPPYAVPGRRYITSFDPSTGYHIGTFVADSSVEIGEKIRRAAEAQRTWRNTAFRDRRRVVRSLKKWLVDNQEVCARVACRDTGKTLLDAALGEIMTTCAKMEWLINHGEKVLRPETRRSSLMMSYKTSQVHWEPLGVVAALVSWNYPLHNAWSPILAALFSGNAIVLKCSEHVIWSSEFFVLVIKECLRACGHNSDLVQLVCCYPEDAEAVTKSPEIKHITFIGSEEVGRKVVAAAAENLTPVTLELGGKDPTIILPNTDLSRYGSIWMRGVFQNAGQNCIGIERILVHSSQYEEVYAMFLERTKELRQGSALSNPNDGFVPAVDVGSMINADRLVDLERVVAAARDGGARVEVGGTAFDHPYMKDGSYFSPTVVGDVDPQSEIAQREMFAPIGLIMKYETVDEAVELANGTRYGLGAAVFGPNREECIKAAKRLRCGMVSINDFAVFYMNQDLPFGGIGHSGYGRFAGPEGLRSLCNAKAIVWDRFGWLVQTSIPKPLDYPVRSNVQSWEFVSGLIGFLYAEGWRTRIRSLVQLFKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6I0</accession>
    <name>A0A401G6I0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0106410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608672.1">
        <property type="nucleotide sequence ID" value="XM_027752871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6I0"/>
    <dbReference type="STRING" id="139825.A0A401G6I0"/>
    <dbReference type="GeneID" id="38774676"/>
    <dbReference type="InParanoid" id="A0A401G6I0"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="206"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="768"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="789"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="892" mass="98510" checksum="057C37C92D12DEBB" modified="2019-05-08" version="1">MDPGTSTSAGGIKKQEDSDGADSKGNAKPEGKPPVRTLNRVPRACNACRKQKMRCEGADNPPCRRCRHAGLECLFEKPTREASLTGEAGLERIRSLEAHVADIRQTQTTIQNTLLEIATHLRGGGMQLHSRSPSAYPPFTHQSPNSVGSPRVSTPSTAGLHPPHLMLDTAHSAQPAGSHVGTVHGHMQAAMNTSAARLNRDQFAYRSPPLSATGHPTNDFHPHQHRSPSMMYPSPGASQTRGPPGPILPPFSSIESMGPPGPPRSQPTNVSSIRHNPQLQGASSSKRTAPSSSNVTSDSSDVEEDNGELPASGLVAPWEVLRGLADVAIERAAKENGGEVSEPPSRARTASPDARQPRPAKRRKVQHKHPRTFPDVVTKNIISEPEARELFRIFYHGCSTFLPVFDANVDTYDALHERSPFAVDCICMVAAQVRDGGGRPSEMFLRCQEEVQAISCASLFTPVSRQEAVQAMILVSGWSTNGWLSGGHAVRMAMELSMHKAWPELLKRMKANKASTSGKDCQLVISARTWFCLYLFEHQMSYGTGRPSILKDDESIWQCRLLLQHPLAIEDDMRLVSTVELMAIRERVHNNLSPLFDRPVDEITLNVLREADIEFRNWYATWDQAFSQKYEDAAFYRQSLQIQHLHAELFHNATALRGIDGPDDVQGMPPAQRELAIRSIQIGRQILDITVNSPAYREGMKYAVHYTHATATFSASFLLRLARLFPDQCDMQEAKLLAEHLAALLAEVPGKRYALTLQLMLKRLRKRKSVSASRSPRMSRDRQRSQSDASYTSDMIPQSAPVVQQQPISPTYETSFSSIPGAMGHMPTGVPQEFTQYTPNIENIWRGFETTANEQLPVWLSDQTLGGASFSQNGIDAFLLPNDYLPAAPQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6P4</accession>
    <name>A0A401G6P4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0107230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608754.1">
        <property type="nucleotide sequence ID" value="XM_027752953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6P4"/>
    <dbReference type="STRING" id="139825.A0A401G6P4"/>
    <dbReference type="GeneID" id="38774758"/>
    <dbReference type="InParanoid" id="A0A401G6P4"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="535" mass="60145" checksum="B2A5777CD0CD75F2" modified="2019-05-08" version="1">MVLKTHLSVLQETARLHSDASVFMIPVAATNGTELREWQSITYRQFIMDIEHCAQYWTRMFQDNLPQHSVIGLWLGGLTYIDAVHIYGIAWAGYIPQLFSLRLPNPEVIYHLMHRTGAQALIVDASFAPIVFKSPVPFHVAADRRSMAVDKVSLPPMYQPTSADETAMIFHTSGSTSGSPKLVPCSYKWLDAVVSKAWHVSIPKHSHKQDITVWMGSMCHIGQTFMLIGSLLHGACVIQPTTISFSSQELVDMIQRCGLNRLNQFASFLAMHLRASRQDTKVLALLQGLDEVLYTGLPLSREEEDWANRNGIQLKNLFGSTECGAMLLSIGGRHGYKSSFLRPIEGTSYGFFPISPASEESDGDYQDVNGQLLELVILSVSGDCPDGSLRQMDGHYHTGDLFQEIEPGHYISRGRDDDWIKSENALRCDTKAIEDNVRMTCADLVAECVVVGNGRPSPTLFVEPRGEMDGEKLRKQIVRRTRHFHSRRYLHERIASEKFIVVVPPNALPRTATKGNIRRRAVEEVYRTELDRIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6W6</accession>
    <name>A0A401G6W6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0107800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608811.1">
        <property type="nucleotide sequence ID" value="XM_027753010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6W6"/>
    <dbReference type="STRING" id="139825.A0A401G6W6"/>
    <dbReference type="GeneID" id="38774815"/>
    <dbReference type="InParanoid" id="A0A401G6W6"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="3">
        <location>
            <begin position="40"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="236" mass="26581" checksum="8489BB9F5729FC06" modified="2019-05-08" version="1">MIERLERRWGRSRGQEYSPSFGPKQQRLAQPKRVCSTDREFFTFAVAGGGKSESLVNAFRGVRNNESGTPATGVIETTSPTIARCTDPNPQNPKLVCIPTTKGFTLSTVIVVFDNRFTATDIALLRNCEPFKIPSYIVRSKSNQNIGNVMQDMGHDSDEVDRLDVYRKARDKYIAETRRSVAQNLADAQLLLQRAYIVYKDALVKFVNRKPTKGIIDGLELPRDLLRETHSGRCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Y6</accession>
    <name>A0A401G6Y6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="15">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0108000</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="15"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608831.1">
        <property type="nucleotide sequence ID" value="XM_027753030.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G6Y6">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6Y6"/>
    <dbReference type="GeneID" id="38774835"/>
    <dbReference type="InParanoid" id="A0A401G6Y6"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000022">
        <property type="entry name" value="Blast:Putative DNA helicase Ino80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="20" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DBINO" evidence="19">
        <location>
            <begin position="504"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="782"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1357"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="298"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1560"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1588"/>
            <end position="1610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE77918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1619" mass="181423" checksum="E08FAA29C0105840" modified="2019-05-08" version="1">MSLKHILNDDPTPPLHISAPAAQAPVPTSVIDPALMSRSPSSTTTMSPSLQPQPFVQPRTPLDLEQPPPPRGYSYQPVAYQGAGGGNYYSEHDDQASVSPPPFSNGGQMPTTRFKEGYVESNGRRKRKHMDDDEDYHPPGQKRHSRRHPPRTRQQHRAQTPASSDTHEDAPVAEELSEHIEEDMKLSSSDLEDCEELWTGELGNYIVETHKRQKQVDAFFSRWIIERDSLTAYQMSHSYRNRIARIPLPPPPAPPPPPPPPVQLEVDEVLRHVSPPLDGYDTVHGDFVHADGSYGAGPETVAREMDDTALGVTAKRRGKGKGKESKKRVPPPYSDSGSEDIPISAKIGPAHKKRRVDKVTTGNDVASIADEFQRSIIPGDSMVPSPAHKLVALAKGKGKGRQREHSVESVATTPKPRRKPGPRKKYDTLPPQTQEYLGIASASVSVAGDTTPVGSRPASPALTVASATLYELDEAIPPLKRAKRVDEAAMLKRVKMLEEAQRKVWTNIARKDVAKVYKYHSQGFLARQLQCKRIADQCSSQARRPLVRTIKSGKDVQVKGKRLMREMLVFWKKNEKEERDVRKREQKEASDRAKIEEEKREAARQARKLEFLISQTELYSHFVGNKLKTAELEGGAAHIQASHVPAGAHLEDVEAGVLQEIDFDEEDPTNIHQHARANAQAAIALAKQRAEAFDTQAALERKTNEALKLAKGQAHIHGEESVETVDSSSGSGLPATPLVDLDSDELNFQNPTSLSDELTIKQPKMLMATLKEYQLKGLNWLATLYEQGINGILADEMGLGKTVQSISLLAYLAETHDIWGPFLVVSPASTLHNWQQEITRFVPGLKALPYWGNVKDRTTLRKCWNKKEISYDQDAPFHVLITSYQLVLQDQQYFSRVKWQYMILDEAQNIKNSSSNRWKTLLGFQCRNRLLLTGTPIQNSMQELWALLHFIMPSLFDSHDEFNEWFSKDIENAAENKGSKLNEHQLRRLHMILKPFMLRRVKRHVQNELPEKIEIDVYVDLSARQRALYKGVLAKVSVADLLQKAASIGKNAESTRSLMNLVMQFRKICNHPELLGRADVVAPFSFAKFGQSGPLIREGDTVQLPYSTRNPIEFIIPTLFYNDGGIVDVPREHAEKDTARLATLMNIWSTDRIQHSLYEGKHSGFSFLRFLDMSPSETHAIHMARLIQRQLSASYAEAHRLEDEPYSLDPVFVASLASGRYKMSTGIPLGALELTGELPDVRHISTSAWQSSCLSRRDFKLFVPPVVAPPISVYCANRAFIEHQANLLDSPLESLALYGIPPHMWESQDACSEYQRRVLGVPVSGLFGASSPDQLPLSSMQIPEAKRLIFDSGKLAYLDTLLQELKAGDHRALMYFQMTRMMDLMEEYLIYRQYKYLRLDGHSKLDDRRDMVMEWQTRPDIFIFILSTRAGGLGINLTAADTVIFYDHDWNPSNDAQAMDRAHRLGQTRQVTVYRLITKGTIDERIVQLARVKKDVQDIVVGNKTFTDVTKPSEIVQLLLNEDQLVNLDKDVATKSTEGIPTGAVAGTEGAVEDLWDEDGDEFFGPSQGGVNAEMLEEEPAPAPAPTRGRKRKDPNAPRKKPGPKAKKKAPVADEDAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G723</accession>
    <name>A0A401G723_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0108460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608877.1">
        <property type="nucleotide sequence ID" value="XM_027753076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G723"/>
    <dbReference type="GeneID" id="38774881"/>
    <dbReference type="InParanoid" id="A0A401G723"/>
    <dbReference type="OrthoDB" id="2674421at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="56287" checksum="71529BBED24E1CF6" modified="2019-05-08" version="1">MEHSMSTHSVLGSTDSSSVIDIPERFSLEESSAEDVPPYSAEVMLRPVTAFQNSRYDRNFLIRPGNVDIPAGLHSSMCLPEPTYLPQGWTLQVHPEGSPYYVNALKVPCVVTDTPLHDPDLCSKLTSSIEVFHYNIKNLNLTLPSDCEIYVHVDSTQGGCSYYLVDHDCQTIFWLQTMDSDTLGLPEISSISHLRYVLHEQYWTHVDYFPHRPVAPRLRQELMSILRHARGDHLTSENSTFPYDAEQCAMYIDLLNIEADCTTYMTCVIARIWELVSRHRYQHFYGEDYSRLYRGQRRLELPPAEGSILTKLRSYFLFGLPGRTKCELEMLFTDRLVFRVDWQKFQRSLALEWRESALLSVGLLVTNSCFFALPRNFASSCAGLSSLILSLSGLATSVALLRWQSGSMNLDASSIAEHMQNIQHAKLGFEPIAAVFSVPRALVYWSMLFSAAHLVAVVAEMTGLVEKIVMLVVVALVGFVLCRMAIVLRGAPIEKTVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7S4</accession>
    <name>A0A401G7S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc/cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0110900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609120.1">
        <property type="nucleotide sequence ID" value="XM_027753319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7S4"/>
    <dbReference type="FunCoup" id="A0A401G7S4">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7S4"/>
    <dbReference type="GeneID" id="38775124"/>
    <dbReference type="InParanoid" id="A0A401G7S4"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="7"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="355"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="472" mass="51235" checksum="63BC0FDBA70E0D37" modified="2019-05-08" version="1">MNRSTRIILLLVIDVLFFFVELIVGYAVGSLALVADSFHMLNDVMSLVVALYAIKLTNQTHIDARYSYGWHRAEILAALVNGVFLLALCFSIFLEAVERFFSTPVVSNPRLVVLVGSFGLASNIVGLFLFHEHGHSHAHPHSHGKESIPVSKPASIHSTEDAERTPRVAPLAIPEPRSRTDSYSSLYGHPAATRASMVAAAQDIALARSPSPSRTSRSRSHARFRLDEEDAEDSLAGSSSGDARPANETTPLLASDTVSVASAPHSLHEEHTHAHGAHGHSHGSMNMRALLLHVLGDALGNVGVIATGLVIWKTSWSFKYYFDPVISLVITVIIFSSALPLVRSTSFILLQGVPSTVSIDEVREAILAVDGVLSLHELHVWQLSETKIVASVHVMASRNHDFMPVAAHIRKALHHHGIHSSTIQPEYHPSRGSPPEERLKTSAETSCLILCPPDQECNPSENACCPPPPIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7T0</accession>
    <name>A0A401G7T0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0110970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609127.1">
        <property type="nucleotide sequence ID" value="XM_027753326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7T0"/>
    <dbReference type="FunCoup" id="A0A401G7T0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7T0"/>
    <dbReference type="GeneID" id="38775131"/>
    <dbReference type="InParanoid" id="A0A401G7T0"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019459786" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="41"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="172" mass="19017" checksum="80A74E40C7A1F543" modified="2019-05-08" version="1">MPRLSFLVVLAAVLANVFAIVPAEQQEIVQGVSSFSDNWRWETCGNPTDPIHIQSIEVSPDPPEKGADLTVTVRGVADKAVEEGAYADVTVKVGAIKLLHKEFDVCEEARNANVDLACPVTEGDHQVIHTVRLPKEIPAALFSVNVQGYTVDDEDLLCLNLWIDFRKKFFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7U4</accession>
    <name>A0A401G7U4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0111010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609131.1">
        <property type="nucleotide sequence ID" value="XM_027753330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7U4"/>
    <dbReference type="STRING" id="139825.A0A401G7U4"/>
    <dbReference type="GeneID" id="38775135"/>
    <dbReference type="InParanoid" id="A0A401G7U4"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813:SF1">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42813">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="5">
        <location>
            <begin position="45"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="4">
        <location>
            <begin position="163"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33843" checksum="1ACC7252DF5C8C44" modified="2019-05-08" version="1">MGAFPTVVHPEYKIREDGSIMRALAWFGTRDARLIDAPIPDISAPDDLILKVTGTTICGSDLHLYNGEIVALQTSLDMRVGPNMRNVKIGQRVVASFRLQWYGHRNAAFFGHSHFAGGFAGGQAEYVRAPKGNVNLLSIPNEHNVMDTGVQEGDVVGIWGLGPIGQCVAQFAKMKGVKRIIGIDRVPERLAFVRDKTGIETLDSAQHTDVVKRLQEIAPGTLLHKVEKALMLETDVPEIVNEMVMSVKKGGRCGVIATYAGHCNHFNRGALMEKGVRLFGNGQAPVHKWWKEILYDLIIPRKFDPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G832</accession>
    <name>A0A401G832_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0112160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609244.1">
        <property type="nucleotide sequence ID" value="XM_027753443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G832"/>
    <dbReference type="GeneID" id="38775248"/>
    <dbReference type="InParanoid" id="A0A401G832"/>
    <dbReference type="OrthoDB" id="2592504at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339:SF1">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7726" evidence="1">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="115" mass="13256" checksum="A06A37F701C20D7E" modified="2019-05-08" version="1">MQLRRRQDGDLAIYDDCNEIRRKIRLLQKTPGWKVTQWLRDIGNVNSNSYGRFMKASGPHGGAGNSTYYAAYIYFEKVRILEGKKKTAKRLRNEGEYAGGLPQEDRSRVWVFGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8I5</accession>
    <name>A0A401G8I5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0113480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609372.1">
        <property type="nucleotide sequence ID" value="XM_027753571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8I5"/>
    <dbReference type="GeneID" id="38775376"/>
    <dbReference type="InParanoid" id="A0A401G8I5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="193" mass="20769" checksum="A2D48A5842B4E282" modified="2019-05-08" version="1">MSPTATSSSSAGPEITHPYSIIPPSSCFTPLSLEESLFLPRVTPAELMEMASYPGLAHITRSELTRSYEGIPEAETDEADYEADREDECTRTIEPVRRVANSKRARIVRPLLPNPIANQPEKARAYVGLGLGLPSSVTPRITRRTACIGLGIILSSPLADNLPPAITPPSMHCDSLRRPFAGIGLGLGIIIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8K0</accession>
    <name>A0A401G8K0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0113840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609408.1">
        <property type="nucleotide sequence ID" value="XM_027753607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8K0"/>
    <dbReference type="GeneID" id="38775412"/>
    <dbReference type="InParanoid" id="A0A401G8K0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="203" mass="21344" checksum="D29E4BE47E76FA16" modified="2019-05-08" version="1">MLDSRLPEHQPHASSSESANVDVSGDDPTQLRPDSTVPSTSVVALHTTHVDAQSIPLVVPFDPLADEFDPPTPYSLPTQSKTTSASGTAGTGVAPADSDLRATAADAPAKLKRKSPKMKANKSNDASNLFAIDWLPTNQGKSRDEFSAAWAAVDAETRKKYEVLSATKKTAAKMEEAAKRKASRATKATNKSNANIAGASQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8Q7</accession>
    <name>A0A401G8Q7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0114180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027753641.1"/>
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    <dbReference type="STRING" id="139825.A0A401G8Q7"/>
    <dbReference type="GeneID" id="38775446"/>
    <dbReference type="InParanoid" id="A0A401G8Q7"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="534"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="555"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="591"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="627"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="672"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="708"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="744"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="780"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="816"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109904" checksum="7F8722560996095C" modified="2019-05-08" version="1">MSTTLEAPTSPADSRPSSDDKKQAPPAFLDLADSAARYGSNIPDVTARTMKRMEHERQRALQRRMFEDQMRALEQKQARELLTIPLDPNQHLAVSAPTTPPRVNAVLHEELSAGSGLSHLSMDAEVLSKAVGSAASDKRKSVTYAPSVNHSPEIQTNNMGTQSFARPGGAKSMPASRRTSASEHDEELAGHLQGLALAAERADRVSTSSGLIPQSILRSSSGRYGSSDNQHFTTTFNAGMMLDEQLDQEMHNAMRHLPTSDEDKYPNAYSNKLSTSSAALDLAPLSQTPPRPSFVGRALETREKPSEWPQFNGNSRVDGLNSRTERRTVTNPAMSLSAGLGDLSASTGSVSGSPLLQQVQGLAQGLSASRRGSPLGIADALSITTARSVPATPLPGIPNSASHLAKAPGTPLSGDAQGLNGMLSASRLGDESELNPSLSRMSASQYDGSPITFNSIQSGLEDQQYGVDAVYGLNGGLDSGRYESYGFEANGRINNVNAGTGSTALYNHHGSRYGLAINGRPAGADSKMNGLHGPKHKRGDMDREFNRFAGTRLEDLVGEIPTLCKDQHGCRYLQKKLEEGIPEHRDMIFRETFGHFADLMTDPFGNYLCQKLLEYSTDDQRNVICESVAQDLVNISLNMHGTRAVQKMIDFLSTRRQADLKYDAQIHSIIVALSLHVVVLIKDLNGNHVIQKCLNKLAPEDNQFIYNAVAANCVEVATHRHGCCVLQRCVDHASDQQRIQLVNEITFNALTLVQDPYGNYVVQYILDLNDNRFSDAVIRQFTGNVCALSVQKFSSNVIEKCIRVAEHSTRKMLIGELLNRTRLEKLLRDSYGNYCVQTALDYAEPGQRALLVEGIRPVLPLIRNTPYGKRIQNKLQREHMDGYSAGFHHNQQIVTMAIGNQGMGMGPTHGSSRHMSHQLHQAAALADAYTNPNGMYGGQNSLTQNQLHGASILQHPIDGYVMQGSSNHSPGLTPPHSHAGSFSGVSAYAGVNSFPAIGITDPYQRSFAYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G943</accession>
    <name>A0A401G943_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0115690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609591.1">
        <property type="nucleotide sequence ID" value="XM_027753790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G943"/>
    <dbReference type="GeneID" id="38775595"/>
    <dbReference type="InParanoid" id="A0A401G943"/>
    <dbReference type="OrthoDB" id="2803426at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="61" mass="6808" checksum="8DF69E42F5AF682C" modified="2019-05-08" version="1">MLQAAKLEMVDFDWAGKAAQVFYPVRRHDQINSSVPAGCSPAIEAGHDRQTDNSWWQSFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9B5</accession>
    <name>A0A401G9B5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dbl domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0116440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
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    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019355844" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="122"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="313"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="719"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1141" mass="130216" checksum="FA9690942CE399CB" modified="2019-05-08" version="1">MFWRARPALGYKFQLVAGRLFLDFGVDVAMTDRYQDVDPPISRLSSITLPTTPVLPPDSDLTNLLSDSLSVTTINSDYRVYPLKDPGSSSEFLTDSSSHWNRTSRHTAETSSDFPEAIADINKQGTIHQLIHQETHYLRSLDAIKFIFDETLRQARPLDMPPSEWNVFIEQTIGNVLRLSTCSRKLLETLHTRVRSLGPLIDGVGEIFINMQAELDGAYSTYIEHLPVMIRNTNYMDENVGFHRFILLYTEEYFDLQHLLDQPSEQLGKYAITLAALRSANMDNIVEADNLSLAIQRMERLQTAARLCKREVQRQSLIFELIRGEIDYVRDLESFNTIYVAPLRHADPPIIPKERETQFIQDVFHNFAELYMHHSKMLSEFFRIQREQQHLIRSIAKEVYDAVLHFRDAYLDYLLNYPFAEYHIDYEAARNSAFRAFNEECLRHPDARELSMKNMLNRPSLRLFRYWLLLEAMLQETPQGHEDHDIIPRAMEIIQTLYDETEAGVELAKKKVEMWHYCANIIIKSGEPNGLDLMNEERSLLHSGQLILQQDRSIFERGHASTNLHVLLFDHYLVMTEPKEQDMITKYHVYRRPIPVDLLTLTIGNGPPTYPRGPTVLLFLRSESDTRRSRESALLQNQLIEPFTVYLGTIGHRGKPDVSYTFFTSSLPARDEWRQKLQQVACPTKIFKIKSLGLHEATALNAGHDSTIPSLEDRAYNIVGKISCSVKFALSDGGTIVIVGGSNGLYLRFLDDSPAHYRVLHLRLVTQCAMLEKDGILLVLAEKSLFAYEMDMLALALSSSRTAEQSASLPRQQLNGDTSGDRNVQFFSVGKLNGRTLVIYSAQGQGESHFVMLQPIVGTDRVRLKRSPTAYRSQITPLSRYTLWFERYKTFTLPLDSFDILFLRSVIVILCSKGLRIVDPEDLKEATMPTRGAPPPNDESANMSTDISTVDRFLRLGFRNSNTTTNVQKHNDPRLQMIYKRCETCRPLGIFRTQDGRFMLCFDEFGLFVDSGGRVGLSAQMIEWEATAERTAFHPPYVLLFNSRFIEIRHVETGNLMQVILGDDMRCICDGRSGANVTTSSVLGPEGWHEGPSQDSRVHVVMRAPRLDTGPDCIFELIPTIPLFLPKSTPLLDSTLLAAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAC0</accession>
    <name>A0A401GAC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0203120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610028.1">
        <property type="nucleotide sequence ID" value="XM_027754227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAC0"/>
    <dbReference type="FunCoup" id="A0A401GAC0">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAC0"/>
    <dbReference type="GeneID" id="38776032"/>
    <dbReference type="InParanoid" id="A0A401GAC0"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="254" mass="27552" checksum="02A4674FCA03ECCD" modified="2019-05-08" version="1">MGRVIRAQRRSHAIFKAHTHHNKAPARFRPLDFAERNGYIKGIVKEIIHDAGRGAPLARVVFRDPYRYKLRKETFIATEGLHTGAFVYCGKKATLAVGNVLPVSQCPEGTIVSNVEEKTGDRGALARTSGNYATVIGHSADENKTRVRLPSGAKKTISGSCRATIGIVAGGGRIDKPLMKAGRAYHKYKAKRYSWPRTRGVAMNPVDHPHGGGNHQHIGKASTIARSAVPGQKVGLIAARRTGLLRGTVKVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAH4</accession>
    <name>A0A401GAH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein scd2/ral3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0203460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610062.1">
        <property type="nucleotide sequence ID" value="XM_027754261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAH4"/>
    <dbReference type="FunCoup" id="A0A401GAH4">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAH4"/>
    <dbReference type="GeneID" id="38776066"/>
    <dbReference type="InParanoid" id="A0A401GAH4"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="122"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="275"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="568"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="712" mass="78884" checksum="DF0ADC12624BB8FB" modified="2019-05-08" version="1">MMKTLRKSLSHKDHVAHISQPSALPSLSKPPSAILPPKKVIRALNSYKSRAPQELSFEKGDFFHVINDVNNAGSWYEAHNPMTGARGLVPCCMFEEFQKGTPIARVVPAATSERPLSTAPKLQAYYAVVLHDFVAERADELDARAGDPVTVVAQSNREWFVAKPIGRLGRPGLIPVSFVELRDPANGQAIPDVNGLIDSGALPRVEEWKRAMMSYKANSISLGVLEETPRVNVMDDLPKPQLAIVVQGPTPPAVTHQQQLPAPADILGPATPKSLPEGILLSADVKSFHYEMEEYWFRVHALFQPYDPSGSNALPPARQLVLFRSYNDFYDFQVELLETFPQEAGRPDHASRILPYMPGPADQVDNEITGSRRAELDDYVHRLCALSQYASYILEHRLIRMFLAPKPGDAELEVGPRVEEIEALARSSYENQQNDEQADLESDVRTDQLARMQIAEKPEEPTSDGSDYEEEADILGRPYEDTYKYRPDEHAQSGLSSSQTFSNTAPLRPKPRIPVDERAEASTSIHGRSGTTTSYQQRSYPQSIPSSSSGNGAGGRLLEAQRSHSSLEIDPYYNNPVNTHSRSSVTSSHEPSPTSMRSSRAGSIATSGTSNSGRSRSQSNATHNPPISSTNSQTAFIKIKIFDRMTDDLVAIRVHPRVTHAQLLDKVQARLGGNALNLRYRDSTSNEFVDLEGDDELRSWLDSTERHVLYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAJ4</accession>
    <name>A0A401GAJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0203500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610066.1">
        <property type="nucleotide sequence ID" value="XM_027754265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAJ4"/>
    <dbReference type="FunCoup" id="A0A401GAJ4">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAJ4"/>
    <dbReference type="GeneID" id="38776070"/>
    <dbReference type="InParanoid" id="A0A401GAJ4"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="61" mass="6978" checksum="176AF331491FDED7" modified="2019-05-08" version="1">MAKSKNHTNHNQSKKAHRNGIKKPKSYRTRSMKGVDPKFRRNAKFALVGSRKARLEAKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAL1</accession>
    <name>A0A401GAL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0204070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610123.1">
        <property type="nucleotide sequence ID" value="XM_027754322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAL1"/>
    <dbReference type="GeneID" id="38776127"/>
    <dbReference type="InParanoid" id="A0A401GAL1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="88" mass="9431" checksum="E4C3590FCF4E2903" modified="2019-05-08" version="1">MASRGTIPTQGVGLTFFHHRLALSVTVRQPYTLSSLFCPARLRIGVISVLELEIKTAIKLIAVPARSLTWWLGTSTSPGSGGVITPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCL2</accession>
    <name>A0A401GCL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0210830</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610794.1">
        <property type="nucleotide sequence ID" value="XM_027754993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCL2"/>
    <dbReference type="STRING" id="139825.A0A401GCL2"/>
    <dbReference type="GeneID" id="38776798"/>
    <dbReference type="InParanoid" id="A0A401GCL2"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="15"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE79881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="127" mass="14734" checksum="A277BB40C117F97A" modified="2019-05-08" version="1">MSTPAPFTAAHRSYVKSLYRRYLNNELNWTVRRDLWRAKAMGIRAEFESNRDVHDPRALADILVKAEADLATRAHPDPYRPPEAPDGSKWERNLPPPLGPLFDHEKFNEEHGREPDTKSIEEQEPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE37</accession>
    <name>A0A401GE37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein alpha-4 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0301420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611340.1">
        <property type="nucleotide sequence ID" value="XM_027755539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE37"/>
    <dbReference type="STRING" id="139825.A0A401GE37"/>
    <dbReference type="GeneID" id="38777344"/>
    <dbReference type="InParanoid" id="A0A401GE37"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="287"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="385"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="474" mass="53005" checksum="B466D12E1D66B558" modified="2019-05-08" version="1">MAATDSLMPLDHFDLTFPPAALGAPSSIDEQEALRISNAIDDEIKHDQEARNRRKHREIKVMLLGQAESGKSTLQKQFQLHYASQTIDHERPSWRPIVYFNILKAISMILNEVDDQYFASPDNPPHSSSSPANASSSSSSSSSNVAGTTNSAVADPMWYAELAYLRGKLLPLVASEDALAAELSGGITVSGGRTGVYVRAGWQVTDARVPLSDIGNAPSSRSYTMMNIVGKTLAASQNELKQLWGHAAVVKLLKEHKLRLEEYAAFFLDNIHRIAQPDYLPSTEDILHVRLQTLGVKEHAFNINMGATQYSCILYDVGGARGQRQAWVPYFEDATAIIFLAPISAFDQYLEEDPRTNRIDDSLQLFTTICSNKLLHKATLVLMLNKTDLLRQKLDDGIKVRKYISSYGDRPNTYEEVSEYFRAHFIQVHKRKDTYNRPLYLHFTSMLDTKAMQRIIVNVGESILRTHMATVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF15</accession>
    <name>A0A401GF15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0305030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611697.1">
        <property type="nucleotide sequence ID" value="XM_027755896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF15"/>
    <dbReference type="STRING" id="139825.A0A401GF15"/>
    <dbReference type="GeneID" id="38777701"/>
    <dbReference type="InParanoid" id="A0A401GF15"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="16148" checksum="E2352CD9EEDD5547" modified="2019-05-08" version="1">MRSSYERLRWAHKQIGYELGYTKKLEQLEHAVLINAKITEAIAKLGRNDYREPLRGSYLSSGDTYGDVGRVGESLKHFVRDWSEEGKQERTTIFDPILDLLKEVDAELRPTKRVLVPGSGLGRLAWEISQLGVDRLFNNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFG5</accession>
    <name>A0A401GFG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0306330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611825.1">
        <property type="nucleotide sequence ID" value="XM_027756024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFG5"/>
    <dbReference type="STRING" id="139825.A0A401GFG5"/>
    <dbReference type="GeneID" id="38777829"/>
    <dbReference type="InParanoid" id="A0A401GFG5"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="398" mass="44129" checksum="01942CA36314BE4F" modified="2019-05-08" version="1">MTSITIDEAGTRPLQRIHSTNLPSHSQEPSFVASVLDKLIDSTATHHDVSHTIHAPMHLTHLVSSLHSLIPGIEKYATEYHVGNYVVVRATGEKFFESMPIYGRLGMHLLFYGHTEIKVLHEKSVEAVLEDLSIREGKTYDSPESVKSIPSFIRTYSLELDQLLYPDISYYKCFNEFFYRKLKPDARPVAHPDDPTGICSAADCRLTAYQNVDLAKKFWIKGNHFTVANLLGVAEDSSNAQAFDGSSVAIFRLAPADYHRFHSPIDGVVGETFDIAGEYYTVNPQAVNEPNFDVFTDNKRSVLYMTHRLTGQPVAFVATGAMLVGSIKWTAGGEKGRNVSRGDELGYFAYGGSTIVALFSRGLVTFDEDLLRNSESVLETQMKVGWSLGRSQPPAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFM9</accession>
    <name>A0A401GFM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0307190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611909.1">
        <property type="nucleotide sequence ID" value="XM_027756108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFM9"/>
    <dbReference type="STRING" id="139825.A0A401GFM9"/>
    <dbReference type="GeneID" id="38777913"/>
    <dbReference type="InParanoid" id="A0A401GFM9"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="216" mass="24262" checksum="210B6D1D54F6C9F5" modified="2019-05-08" version="1">MTIHSLYIYDRHCACVYYQDWHRTNRPRPAVEGGILPAVSLAVFPRQEEPALDSTLALTTPRSTLSSASGVVVAVNDDVPRSPLPQPPSAASTSHPQASSAALPFHEEAKLVYGVVLSLRNMIKKISGRDEQFVNYRTSTYKLHLYETLSGYKFVILSDPEADSLRFVLRQIYAGPFLEYVVRNPLMGMDSREHGIDNEYFRAGTDRLIRSLTVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFN2</accession>
    <name>A0A401GFN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0307270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611917.1">
        <property type="nucleotide sequence ID" value="XM_027756116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFN2"/>
    <dbReference type="STRING" id="139825.A0A401GFN2"/>
    <dbReference type="GeneID" id="38777921"/>
    <dbReference type="InParanoid" id="A0A401GFN2"/>
    <dbReference type="OrthoDB" id="2789888at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF33">
        <property type="entry name" value="SERINE_THREONINE KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="438"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="716" mass="80496" checksum="47C9EA0E2FD2A9CD" modified="2019-05-08" version="1">MSDTSQFKLNIAYDILCSTMDHPHVLIVSVSTGMRWVQVAAEIARRVQLAPTFIVLYKLRTPTPTNELRQGLQIGGVEDIAEKVRSLDEVPHDITQFPPDKVHVVVVVVSPPRKAAEVFPWVNLSQTALVKLLQVVIEIPNKWSRNEVTSNGGVFVDRSCSVLQNIVDKLKAKRTYQANYNSPDFQNARSLSHFSQSFISVVGSPGTVEGDKEFATFYHVLRRFSNDAPLVHSDPSSSLKASSFMVYFIHSPFFSGNIQSDPLQYKEQLSWQFPMFVTRRDSLGHVQKFHPNSDFSVVLREFQCPVILSEVVSQKDENDRYRMLVEAIVAARVGKYLLKPTSRKQFFVIAIYLTAFLEVERYIVSEDSSPQKINIQQETFDLCKPSRAVEFLREMYNLKPLLEELAAELDEEKSADLAKIEMDSSKMHSLNSKAPWTNTHPAEYGLGPVAEDDESMNISDDDIGVFNTRSVHSVLDKVNCEIDSVGYGHPHVALVVRKDDGASAGFLKFVKDGNPEIEILQYLSRIDSPANHTIRPIRVWPIEGGRIVSMSVGGGWITYLEDLDARLWGASQQLFEAVGFMHDHGVAHMDLKPGNIVIPPVYGKLSIIDFSIAERVKGPGHKLMGYVGTRGYAAPEVGRAAYCPIRADLWSCGKVIQELCEDVKPSFARTWLREVSKRLMDNDPDKRPMMAEILEAMSRVVHDRDELEPDGVVETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGF8</accession>
    <name>A0A401GGF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0309420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612128.1">
        <property type="nucleotide sequence ID" value="XM_027756327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGF8"/>
    <dbReference type="GeneID" id="38778132"/>
    <dbReference type="InParanoid" id="A0A401GGF8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="279" mass="31571" checksum="099F1BB51F12B502" modified="2019-05-08" version="1">MSSSSTDTSPPSVSGLPPGYSSSRVHPRCPTCTCPRPPPAYSSPEDADHEWVSTAYKQIRIRFLDYTFASDHQCTELHFPLDGDGVLDYGVLAQTLGVKEVMRQEPTFKDLVLTPLREPAAVIRAAIRSCGYLRVVEFSRQERFSYKYGCSISPSNVRVRWYPSPTTDMTLFEEMLEEIDTHDCLSLGSIARKHNILNVQVFDPCKMKQVRTKFRHVLHPRERSRAMGRRGFIAITDAIVPFPVISISDAQVDREVGSAVRDRTGRIMDNYLLTSFDVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGJ7</accession>
    <name>A0A401GGJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0310250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612211.1">
        <property type="nucleotide sequence ID" value="XM_027756410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGJ7"/>
    <dbReference type="STRING" id="139825.A0A401GGJ7"/>
    <dbReference type="GeneID" id="38778215"/>
    <dbReference type="InParanoid" id="A0A401GGJ7"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="388" mass="42836" checksum="7C255E0A2836237F" modified="2019-05-08" version="1">MTAGDDIIPPAYSYAWTPNSDIPLSDFLTKYKPSMVQDDGTKPWLWVRKPVQGRENDNAEAAIEEAAEYLKEVTEKVEVVKNDPSVPIRSNKKKGLKSKKEVREEIQAQATEKLKEISLRHSYVVGKWLIFAPPERVDAIWLTIANSLILGPLSDTCADTAKVATCSQNETANHTHVLCLYMPNVYDKSIVTEVMKVLLGKHGMTLTGVKSDLYTLIGLDSKHPSGVPSTVWKNAALLKDSEIKDLKDKYFAELNTPKDAATDKVTTPAPVKAKPALKKKVVDDDPFASDDNDTDKAKTSERNSAKEAKPASAGPSKAKPQPKKKSEDAFVSDVDEEVEAEASRKAQVAVKKVPAKKKPVAKRSKDSDDDDDNEVEERPKKRLITGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH37</accession>
    <name>A0A401GH37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0312190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612403.1">
        <property type="nucleotide sequence ID" value="XM_027756602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH37"/>
    <dbReference type="FunCoup" id="A0A401GH37">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GH37"/>
    <dbReference type="GeneID" id="38778407"/>
    <dbReference type="InParanoid" id="A0A401GH37"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011949">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02252">
        <property type="entry name" value="DREG-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="246" mass="27486" checksum="1EE0DCABE5849103" modified="2019-05-08" version="1">MAIRLVTFDAMHTLLVARLPVYVQYSRTFEPYLGILEPGALKKSFKTALKQLQQEKPVYQSGATGWWGEVIRRTAVGAGADPQVVDRSLAEIVPRLLHCFSSREGYKLFDDSMLALKRLKEVNVHTGLISNTDVRMHRVLADLGVHQYLDVTLLSEEEGIEKPSREIFLRACSRVGVKPQEAVHVGDELRGDYRGAKDSGMSAFLLRRPGPEGEWESKEDGENLAGVDVVPSLLDVVEWVKQRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHE4</accession>
    <name>A0A401GHE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0313450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612529.1">
        <property type="nucleotide sequence ID" value="XM_027756728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHE4"/>
    <dbReference type="STRING" id="139825.A0A401GHE4"/>
    <dbReference type="GeneID" id="38778533"/>
    <dbReference type="InParanoid" id="A0A401GHE4"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="365" mass="38507" checksum="1B9788F08999995C" modified="2019-05-08" version="1">MNEVLARRRSWTQQVSTLGEKLGRRLSVSAKSRGEDGGGTKEKIRREDGSYLRLVDDGDSATPARSVSRGREVYHSSGRGGLGNIRPASQDPASPSPSREPQDPDNFSPVRGREPSVKDTPLDRIVSTGRGGAGNIRATSRSMSRDPNAIEEEKYEASVIHASEEAARAGVYHSGRGGVGNIHPHSPSPAAYPPSAYPTSLPKSESRSRSRPPLHSTGRGGAGNLRTGAVADSEVAEVADIEEAERARKAHGEGVHSTGRGGAANVTAVPAPRSPSPAPTHPSDAPTSTGRGGTGNIHSREPSAVRSGDARSPSKEPGHHHGLAGVWNRVAHPHPHPHPEGERGRAREAENGLAKPEMELQELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHI6</accession>
    <name>A0A401GHI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0313370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612521.1">
        <property type="nucleotide sequence ID" value="XM_027756720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHI6"/>
    <dbReference type="FunCoup" id="A0A401GHI6">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHI6"/>
    <dbReference type="GeneID" id="38778525"/>
    <dbReference type="InParanoid" id="A0A401GHI6"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="63"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE81608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="321" mass="35567" checksum="A9D5D37A04E84D62" modified="2019-05-08" version="1">MDKKDYMDVDGERDAVRPAKRARHTPPPDPSVPSTSYQPQNGNGHTETLFPLSQSILGAEPLDEFTREVADFVHAMINSRPAGAGTVEVEAKVGVLRDKVSGQRLQLPVLVETILLPNSFEYRFESNMSPMQHKHLNTLLNNLMLTSKTSYAPTPSPLTYTHLRLVDSFYQADGHDRIRVTRDEKTGEVHACVRKVRLGDLDIFSPKRAADWRISVNVEIPVPPPLGLATHSRRKDRMSYAHEECVIDLTQVTSSAGPSSKPEVLHELEVEIARPTYLLATSAKRGDPSASEAERSAFDELVRVFVNNARVLVRNAGISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIG6</accession>
    <name>A0A401GIG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable glucose transporter rco-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0403430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612880.1">
        <property type="nucleotide sequence ID" value="XM_027757079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIG6"/>
    <dbReference type="STRING" id="139825.A0A401GIG6"/>
    <dbReference type="GeneID" id="38778884"/>
    <dbReference type="InParanoid" id="A0A401GIG6"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF74">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE81967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="542" mass="58630" checksum="9E554D6767880D8C" modified="2019-05-08" version="1">MERFRPKTYTARYPRWMVGKPLLIASSALASLGDALFGYSQGVIAAVQVQPPFIKRFFGRSVTIEQIQAGTTGVDPYVQAITVACLNITALFAALGSAYVCDILGRRMSIRIGAFIYLVAAFIQLFAPDLGTLIVGRSIQGLAVGMLSMTVPILQCEIAPGHARGLFISVEYLCLNSGYLLSSWVGYGFFFALPSEISWRGPYIIQAVLAVMLLVWTFVLPETPRFLISTGFEEEGLRTLADLHAAGDIDDPGVQRTYAEIVAAITYERTLGEASWGQLFKQYTRRTVMAITCQMFAQFNGINALLYFLPSNLTRAGFSIASALLYSGVSAIVYCLGTIPTMFLIDKWGRRPFLLTGSAALAACLATVGGLQYHADSLPVGNARLPSADGIFAAICIYLFFYGATWGPGPYLLGAEIFPLRARAKGMALSITSNWLCNFIIAFITPPLFSSIGGGYYFLLLGFCVVSGVFVWFVYPETAHRTLEEMGAAFGDKISIDQVVANSRLGSAAAKDEDLQSEATTLRASIGDKSVLSGRKGSDVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIN7</accession>
    <name>A0A401GIN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0403410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612878.1">
        <property type="nucleotide sequence ID" value="XM_027757077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIN7"/>
    <dbReference type="GeneID" id="38778882"/>
    <dbReference type="InParanoid" id="A0A401GIN7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="88" mass="10342" checksum="43CFF9819BDA3E1F" modified="2019-05-08" version="1">MPLLVSGQHHPRSTSNWNALPFRHPHRMLVHPAMPPRAHIRQHSLHFTTQQFDELDNLASMMLHESEMEAEHPSKSKSHDEEHWDVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKE8</accession>
    <name>A0A401GKE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxynaphthalene reductase arp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613556.1">
        <property type="nucleotide sequence ID" value="XM_027757755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKE8"/>
    <dbReference type="STRING" id="139825.A0A401GKE8"/>
    <dbReference type="GeneID" id="38779560"/>
    <dbReference type="InParanoid" id="A0A401GKE8"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="266" mass="29193" checksum="9BC35E25D83DF361" modified="2019-05-08" version="1">MLDRLHRMLSLEHPIFFSNLKGKLLSSSPAAHNGGIGQATACTFARSGCSVAVHYQAASSHAKADTLISDLKAIASSDLQFAIFHTDLSNYDEVRRLHAEVVQQIGHPDILFANHGIAGPKIGPLGNINDVPMEVFEEMWRMNTGMSYMLAQLCVPHMEAQKYEHAIFMSSIAAGNSGLIEPHYTSFKAALHGLVHWLSLWYAKDGIKSSAIVPALIEDTATMANLMPEMRSKIPIGQLGKPDKMACRTCCSHPLPHSYSRRCPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKH0</accession>
    <name>A0A401GKH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0410500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613578.1">
        <property type="nucleotide sequence ID" value="XM_027757777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKH0"/>
    <dbReference type="STRING" id="139825.A0A401GKH0"/>
    <dbReference type="GeneID" id="38779582"/>
    <dbReference type="InParanoid" id="A0A401GKH0"/>
    <dbReference type="OrthoDB" id="2740102at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="292" mass="33157" checksum="711548ABB04B50F9" modified="2019-05-08" version="1">MSTLRLEFDIGINWTDDGSFDPIILHRPTSSLSDITCDDSSQSETLYVRQGKRIHRGRSTLVWAAQMQRGGESPIDIVFKLTTLKAHHDDLLKEAGFYQNELATVQGKIVPKFYGIFQGHFGSRFITCMVLEHCGQPMREAQYQNLDFKVELVNRLQYLHSSCGIEHGDVCGGNILVSHGYPVFIDFEHARPHNCKRSMAIEVGKPWPQVLEFGCFELHDAGKYFGIWGPAIVEFLDDCISVYQITSPKRLVELTLHNDYIDPDDALEQAQEFVQYLVNRGTLPKSVLTMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKP5</accession>
    <name>A0A401GKP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carboxypeptidase C</fullName>
            <ecNumber evidence="2">3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0411040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613632.1">
        <property type="nucleotide sequence ID" value="XM_027757831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKP5"/>
    <dbReference type="STRING" id="139825.A0A401GKP5"/>
    <dbReference type="GeneID" id="38779636"/>
    <dbReference type="InParanoid" id="A0A401GKP5"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019159552" description="carboxypeptidase C" evidence="7">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="512" mass="56738" checksum="92EF5845AE1C6E70" modified="2019-05-08" version="1">MFTLFKTVLGLLICATVVHGNVQHPFRARLNTVQPPPRIHPSNQLRTPLAAESYDTGSFSAVGDPTLLSVSHFTTLSHPAFPNHSVRIKKANICDGDEAYTGYFDIEARHLFFFFFESKNDPDNDDVIFWTSGGPGCAGSLGLFMDFGPCKITNPNGTVHNPYSWTEKASVFFVDQPIGVGFSYADYGETVSTTEEAAKDIAAFVAIFFEHFTKFKGNAFHMASSSYGGRYIPVFASEVYDQNAKLVEAGMTPINLTSIMIGNGCTDVTTMLPSYYDMQCTGVTAPPKIGISSCVRQKLALPRCERWLKESCRDSYDAMNCRAAVDFCGAEIEEPFNSARYNPYDILKPCDGDIEETLCYPVTNAIEAYLNRPDIRTILGVDPAISGNVSACSNRVNDDFNSAGDYHFPTQYYLAALLERGIRTLLYVGTRDWICNWVGNERMTVAMEWTGQEAYTAAEKRKWYVDSEVAGLVKSVGPFTFATVHNAGHMVPYDVPKESLAMINRWLAGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLH9</accession>
    <name>A0A401GLH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0500840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613954.1">
        <property type="nucleotide sequence ID" value="XM_027758153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLH9"/>
    <dbReference type="GeneID" id="38779958"/>
    <dbReference type="InParanoid" id="A0A401GLH9"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="70"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="269" mass="29248" checksum="8191E10972923248" modified="2019-05-08" version="1">MDMGSISDLPAFAHDAPAKFTVPPAPAWTYAQKVDATPEGCEWVAGEKSGFHGVDPATTDRTKLYALMTSGIVPRPIAFVSSISEDGVENLAPFSWFNMVAPDPPLISFAVRHEPRADGLKDTLRNVLKTKEFTVNIISHAFVENANATAVDAPAEISEWPLSGLTKEPSLKVKAARVKESAFSMECELFQSHDIVHPESGETTSTLVLGLVKYIHVRKDVLNERGLVDPVKLNAVARLGDITYARQGDLFRIPRPTWAANGEVISGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLR4</accession>
    <name>A0A401GLR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614054.1">
        <property type="nucleotide sequence ID" value="XM_027758253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLR4"/>
    <dbReference type="GeneID" id="38780058"/>
    <dbReference type="InParanoid" id="A0A401GLR4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="197" mass="20986" checksum="ED7EC1809DEC268C" modified="2019-05-08" version="1">MAPNRLIEDLSAHHNLPAMASDAEPPDTLDIMMGESDEEDSIAEPRRPLISDLLDSSGSAQISLPLHSASQTPLAPRHTTPSLAVPFVPSNSPHAHLHRHASPKVQASSGSVAPVEGSRALIPDPLAPAWDESRGSSPIHRRALISDSTPTAPGGMFDFDTPGISPIPRRTLLEATPLPPPAHTFDFRTPDTSQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLZ1</accession>
    <name>A0A401GLZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">54S ribosomal protein L20, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0502530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614119.1">
        <property type="nucleotide sequence ID" value="XM_027758318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLZ1"/>
    <dbReference type="FunCoup" id="A0A401GLZ1">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLZ1"/>
    <dbReference type="GeneID" id="38780123"/>
    <dbReference type="InParanoid" id="A0A401GLZ1"/>
    <dbReference type="OrthoDB" id="6021263at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="175" mass="20197" checksum="B7ABA7F87190594F" modified="2019-05-08" version="1">MKLQLVLRRKLCRTYATRLPQRPPYRAPDPLKNNPNAVSLPEDLTFIHRSPPSAPSPLSYTTSPASPLLHPEPSSSSSLPPLLRTDKPQSPRLSQEDLLKIRKLRVEDPLTWTRSKLAKEFNCTPNFIGRAAAMKVRDRKKVLAQRDEEHEKARGLWGEKKSLFREIAKKRRDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMN4</accession>
    <name>A0A401GMN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0505220</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614386.1">
        <property type="nucleotide sequence ID" value="XM_027758585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMN4"/>
    <dbReference type="STRING" id="139825.A0A401GMN4"/>
    <dbReference type="GeneID" id="38780390"/>
    <dbReference type="InParanoid" id="A0A401GMN4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13910">
        <property type="entry name" value="CuRO_3_MCO_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="568"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="695"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="949"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE83473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1067" mass="117393" checksum="905507EE6BD26AEF" modified="2019-05-08" version="1">MSFHPPRKVILTKEHLQAFQASKIHDDIVSYIQTLNDAVVNVKLTDECAESPGVSAILRVLNQIEVIAKGIPPVDNKASRFGNPAFRTFYDKVNELSLSLHVTLPGLPREAIPELSVYFCESWGNRTRIDYGSGMELNFLCWIICLERLGVVQKSDHIALVTRVFWRYVEVMRVLQSTYWLEPAGSHGVWGLDDYHFLPFLFGSAQLRGHKYIRPKSIHDPDIVEEYSKDYMYLACIRFIESVKTASLRWHSPMLDDISAVKTWDKVNAGMMKMYLAEVLGKLPVMQHFLFGSILAWEGVLPPPRAESPEDDAHRGHVHTVEDLGGAGQAEVGWGSCCGIPVPSVFGAAQAEKSLYGRDIPADIIGHIPGARLSGPGIRPWTVFVAGIIYSEVLPPPGMTTILHHGSLTLVLFLSLSLEFLRVGTFPHNEEQWGGVLQVTSQNRCSDRALRRTDTPQESRRYCCRASRTALARLEDLGENGGFIQRPTHGFPLWRRPLVLGGIAVGIVVLALALGLGLGLGLRHHHTSVDMNDGFIVVPVQNTDSSAYFLNMSMVNEETTTRYYNWTVTQATGAPDGFSKPMLVVNGIFPGPTIEANEGDRIVVNVTNMMPNATTLHWHGLYQRGTPYYDGTIGITQCGIPPGQSMVYNYTVANWTGSTWWHAHSATQYSDGIVGALVVHSKNESVPSYDGDLALQLSDLYHVFSPIALQEYFTPGGLAGIPGTEPVPDGGTINGIGQYGSYNSSFFNVTLEANKTYRLRLINPGTFVAMTFSVDNHMLTVIEGDGTAVGPYPVSSVSTAVGQRYSVLLTTNQTAGAYFMRAGLDQGAFGYNNPATQLEIRGVIRYGVENDTMPDMSLLNNPPLLPVDAPKAMDTGNLVPVGGGPAPEPTFNTSVTISMQYPANTADYLGHYLAFLNSTSWEPLTGTASLLEHLGNDTADGSASCDGSQLMTIVNEVHVVQILVQNNDDGDHPFHLHGYKFWVLNSGAGDYTDEAIMNTTPMLRDTVVIPAYSWIFLRFVADNAGYWAFHCHIQFHMAAGLLMQFNVLPSVSQQYEIPQYMLDQCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN82</accession>
    <name>A0A401GN82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0507570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614614.1">
        <property type="nucleotide sequence ID" value="XM_027758813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN82"/>
    <dbReference type="GeneID" id="38780618"/>
    <dbReference type="InParanoid" id="A0A401GN82"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="179" mass="20228" checksum="CC05CB0494787CF4" modified="2019-05-08" version="1">MGERLKDIYLAFFSEKQVEIFSRSCCLSLCVNVETLGLILPVKNDLMDPYVHLPLLLSQISPRNHLRHLMFSTRLSLQGDMIDYNHLRDIDAILAQETFRNLREVDFELFLKCNSPPLSTRSQVLQGVKSAMSGIFGRGVGMEPNIIFSYIKPSSWDERCPQGDDNRTLDSAGDLSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNA5</accession>
    <name>A0A401GNA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0502710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614137.1">
        <property type="nucleotide sequence ID" value="XM_027758336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNA5"/>
    <dbReference type="FunCoup" id="A0A401GNA5">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNA5"/>
    <dbReference type="GeneID" id="38780141"/>
    <dbReference type="InParanoid" id="A0A401GNA5"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="422"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE83224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="544" mass="60123" checksum="B55FE938898F6E5B" modified="2019-05-08" version="1">MSYNERAAFQAEVASVERWWKEPRFAKAKRPYTAAQVVSKRGTLPISYPSDVQGKKLWAILSERFKQGTPSHTYGALDPVQVTQMAKYLESVYVSGWQSSSTASSTNEPGPDLADYPSNTVPNKVEHLFMAQLFHDRKQREARSSLTEEQLAKTPYIDYLRPIVADADTGHGGLTATMKLAKMFVEKGAAGIHIEDQAPGTKKCGHMAGKVLVPISEHINRLVAIRLQFDIMGVSNLVIARTDSEAATLITTNVDERDHPFILGSTNSSLPPLVAVLSEAERAGKTGEELEAVEEQWMAAAQIQLFSTTLANALKAQTNASPATLQRFASRVVHVSYPTAVEIAKKEFGLRTVPHWDWDAPRTREGFYRYQGGTQCAINRAVAFAPYADLLWMETKSPILAQAREFAEGVHAVYPQQWLAYNLSPSFNWDAAGLGPDDMKNYVWELGKLGFVWQFITLAGLHSNAYISDLFARAFATEGMKAYVELIQRRERDIGCDVLTHQKWSGADYMDNLMKTVTGGVSSTAAMGKGVTESQFGQGPKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNE6</accession>
    <name>A0A401GNE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0507920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614649.1">
        <property type="nucleotide sequence ID" value="XM_027758848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNE6"/>
    <dbReference type="FunCoup" id="A0A401GNE6">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNE6"/>
    <dbReference type="GeneID" id="38780653"/>
    <dbReference type="InParanoid" id="A0A401GNE6"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="316"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="50840" checksum="D1154530FB937F30" modified="2019-05-08" version="1">MFRITPGLWDKIHHFASFPQTGVSLQQMVLFGQNPSQGTLLRASQFILEELPVRLAHRCKELDQLPHNLSAMPSINKVKDWYAQSFEELISFPSISLPGHVREALTAPATDHFALPESTPNPSLPFFTEDYAGMPSGMGLGLGISSTSRADGNGNGNGNSQKMRIPIERRYYYDTSGIQWPPEVRDYNRRITKTLEIIKKRHDPTVTTVAQGVLEWKRSQNARNINLDVQHWLDRFYLSRIGIRFLIGQHIALNTLQPHPDYVGIICTRSNVHDIVQEAIENARFVCEEHYAMFRGPPVQLICPKDLHFAYVPGHLSHICFELLKNSLRAVVERFGHESELYPTIKVVVVEGKEDITIKISDEGGGIPRSAIPLIWTYMYTTMEGQNIDQDFQASDFKAPMAGFGYGLPLSRLYARYFGGDLRLISMDGFGTDVYIHLNRLSSNREPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNE8</accession>
    <name>A0A401GNE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0507560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614613.1">
        <property type="nucleotide sequence ID" value="XM_027758812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNE8"/>
    <dbReference type="GeneID" id="38780617"/>
    <dbReference type="InParanoid" id="A0A401GNE8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="400" mass="43457" checksum="C0CD65E48B5750F3" modified="2019-05-08" version="1">MSQQNTPKTQEEPILPGNPTPEVKALAVLIPSVNNSMLTGDLVGTPPPHTHPENGQALTAPLIEEPDGFPMSTLSPVSEIGKPLTAEIPSAQPNTRVRHATEPEERIPPRWNLSASGPSRHFGLLHGGCALTLTSAQALRHASQSLDFYPSPGSNYSPNAITAAKTAALAPQTGLTYHHQIGGPEYRNYASFNGQHLPEDFPMEPPSSMALVPTPRPATSLPSLPMMCKVDLLKESKAIPNPQPVPMDEDAPVPTRPPHSHKQRTLTATALQHSRRKMLAQLDGTDSGSASSRPPQSSTADTADITFTPKPSSVFPKVHGEKPVDTLFRQEMSQRNLWIRNADSDPRVAIQVYECCASDKKVNILKQETLQRTLCSLFHHTGIEVEIPVPEVNERLKDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNL1</accession>
    <name>A0A401GNL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0508620</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614718.1">
        <property type="nucleotide sequence ID" value="XM_027758917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNL1"/>
    <dbReference type="STRING" id="139825.A0A401GNL1"/>
    <dbReference type="GeneID" id="38780722"/>
    <dbReference type="InParanoid" id="A0A401GNL1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="70"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="250"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="419"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE83805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="957" mass="108853" checksum="B1889742D610ED66" modified="2019-05-08" version="1">MSQPARPSSSTSDAWKASLRPPPRDDRPQTEDVTATKGMDFEDMFLRRELLMGIFEAGFEKPSPIQEEAIPIALAKRDVLARAKNGTGKTAAFVIPSLQQIDVNKNKIQALLLVPTRELALQTAQVCKILGKHMGVQVMVTTGGTTLKDDILRLSEVVHVLVGTPGRILDLAGKNVADLSECPIFVMDEADKLLSPEFAPVMEQLLSYMAKDRQVMLFSATFPMIVKDFKDKHMRSPYEINLMDELTLRGVTQYYAYVEERQKVHCLNTLFSKLQINQSIIFCNSTNRVELLAKKVTELGYSCFYSHAKMLQSHRNRVFHDFRNGVCRNLVCSDLLTRGIDIQAVNVVINFDFPKNAETYLHRIGRSGRYGHLGLAINLVTYEDRFNLYKIEQELGTEIQPIPQAIDKTLYVAPSAIEEPAEQKSARTTQAPVQAQGQSQQKQQAPQQPQSQAQLPAQVVYNSAPLRQNGVAVPQQSRPVFQTPFRGSVPRVRGITRLLSAGVFTTMSSANYGRLPLHALSRRSSADSLSSSTSPDPSYYPTRRRRWYSSLWNLHRPRTVLMLFKIFLGCAVLVLLGGYILWEPHIELAFYWRGWLKQEINTVVPLAGCFRPENVSPRYNLSAALHGQKKTEVHAGLPLRLGVDCYDFAGTIEPEPHDGVVLLPDERVHYHTYWRTDLAPFGERQEWMLKSFFATQNTNTARLVLWSNGDLSDNAILQRWLRRFPDAFVLQVVNYEDLARGTVLHGSELLRVKDTKAWIDGDLVRLLVLWAYGGVWVDMDSLLTRDLAPLLEHEFVIQWDCYDKIYVPFNGALMRFHEHSPYLCEAFNIMVNSRPPREGSTDWGALLYLKLWRRLTAESIPPFKVLPWCFTDARSCRFDNRLPDPFEQDPINGQWTVGYGREEGGGLDRALAKVFSVHLHNQWRKPFPLGGWLDRLLLRRYDARLSTSFGARESEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNR7</accession>
    <name>A0A401GNR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable sterigmatocystin biosynthesis P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0509250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614781.1">
        <property type="nucleotide sequence ID" value="XM_027758980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNR7"/>
    <dbReference type="STRING" id="139825.A0A401GNR7"/>
    <dbReference type="GeneID" id="38780785"/>
    <dbReference type="InParanoid" id="A0A401GNR7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="425" mass="47680" checksum="FD86C9B37C22014F" modified="2019-05-08" version="1">MFDVSTFAPARLAPVLLSLLALVYIARHAVIRKHQDIERLPGPSRKDATWLWGHELLAFENCTTDMYTRWAVTFGTFFKIKGAFFHRDIIIATDHAAVQHIFQYSDNYVKETGMREVAGTILGRGIVWAEGHEHAKQRRLLAPAFSLEAIKGMTDDISESAEKLESRLTNLVLARDGGATVNVADHISTCTLDIIGRVGFGHDFRSGQSAEAKEIRAVWERQVNESNTFKAFVGSLLLRTFPILTSLPLPVMKEARRTREIVSELAMRLLRHEYFSDKGRDILSILMCAGNKDGEKEKLSSTEVVDNITTFLLVGHETIAGSLSFTLWELARHPEIQQKLREEIRQFGRDFDYDDIQQLNYLDAVVKEGLRLHPAAAMTERVALKDDVIPLNKPVCTSNGQTVLSISVKAGQAGLFLLPHHSPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNX6</accession>
    <name>A0A401GNX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614838.1">
        <property type="nucleotide sequence ID" value="XM_027759037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNX6"/>
    <dbReference type="GeneID" id="38780842"/>
    <dbReference type="InParanoid" id="A0A401GNX6"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="108" mass="11960" checksum="85B7184BE2F3F953" modified="2019-05-08" version="1">MSDLRRRVLDRVSACSEEGLTKVLTANLESIEGLLSKLTGHAAELTFPSLKALSSNIPSGKIFYFQVSDGSRTHVQDLVKSAKEQGIFPLHAWSNAWHPVPSWTRLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPI9</accession>
    <name>A0A401GPI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0601230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615058.1">
        <property type="nucleotide sequence ID" value="XM_027759257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPI9"/>
    <dbReference type="STRING" id="139825.A0A401GPI9"/>
    <dbReference type="GeneID" id="38781062"/>
    <dbReference type="InParanoid" id="A0A401GPI9"/>
    <dbReference type="OrthoDB" id="5344254at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057722">
        <property type="entry name" value="AsqO/PenF-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25581">
        <property type="entry name" value="AsqO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="1">
        <location>
            <begin position="52"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="AsqO/PenF-like C-terminal" evidence="2">
        <location>
            <begin position="251"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="41825" checksum="42F2B6D679196116" modified="2019-05-08" version="1">MFTVLGAPMFRVPATVVFVAALWASYACAAALHGHRPVKDTVPFDGQYLAANSSNTQTEWWYIQGVSEPVGDESPSSVVVVFYQGNVLYTAPAGNMEPEFTISISGFLSNGTTYNVTIPTTTGTITTDGQAVDGTWGTAGKFFLSSDLNTFTVELNSPEYGMSGSIVLTSSASPHYACNVTDDPYFDTAVPAGVSLSPTETALFTEFGWAVTIPGGQAVVDLLIDGTPLQFIGNGYHDHNFSPAAIFGYASQWQWLQAQVGPYVLTGAIMQAINSTLIANTGYLAESGVVVQNQCSLVGSRRVDFNSVTPYGASFDNVTGAVVPQGFLLDYTLEDGEQYSFNLTTVGTFPDTPIYYRWIGTATGGKVGGVQYTGTTIHEWLDPSLSLYTPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPN3</accession>
    <name>A0A401GPN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0601560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615091.1">
        <property type="nucleotide sequence ID" value="XM_027759290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPN3"/>
    <dbReference type="STRING" id="139825.A0A401GPN3"/>
    <dbReference type="GeneID" id="38781095"/>
    <dbReference type="InParanoid" id="A0A401GPN3"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019380070" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="77"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="32107" checksum="9C04495E2AE626B5" modified="2019-05-08" version="1">MKFIAALISACFILAAEAQHDQRMVKRHGRRGPSATYGPPTATLSSTPTLVATPTSTPTSGNKTGDSLSVANGVKRGLSFNDASLTDGFNSGEVSWVYNWASSYSGTIPENVMYFPMLWGGADSYTSVWFDNANAAIANGAEILLGMNEPDLSSQSNISPQDAATLWKTYMEPYAGKATLISPAVTNGGAPMGLAWLQQFFDACTDCTVDACAIHIYDSATNVAYYQSYISGAVSTCGKPVFVTEFGATGSEEQQQQFLAEMVPWLDSQPGIQGYAWFMDTVGNLVNSDGSLTSLGSTYIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ48</accession>
    <name>A0A401GQ48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Oligomycin resistance ATP-dependent permease YOR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0602580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615193.1">
        <property type="nucleotide sequence ID" value="XM_027759392.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQ48"/>
    <dbReference type="GeneID" id="38781197"/>
    <dbReference type="InParanoid" id="A0A401GQ48"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="911"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="175"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="584"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="875"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1187"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="814"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE84280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1452" mass="161503" checksum="A41867729213FE8B" modified="2019-05-08" version="1">MYNPFRPPPAPPAFGEGKVVPEEKASYLSRLIFQWVDPLLRVGFSRPLQKEDLWQLPSSRLTGSLGDEVERNFYARCAPEQRPIFLRDALAASEVERTDSRSDNVSSTASRTQDNTIEDEKNISEEKVDPDEKVLEVEQGQSGKDRAKPTEEDKSKKYDGSLLRALHYTFFWRWWIGGILTLLASTLQTTTPLLNKVLLTWLTDSYAWYRIPEAERAAAGLKQPHGLGYGIGLSFGLFVMQEASSLMTNQYMQMTMTTGLTVRTSVIGAIFRKSLRLSGRARQNHSVGQITTMISSDAARLERVTSFAHNLWVGPTQIVIGVGLLIGTLGYSALVGVGVLILGFPFQVICVRAMFIQRKKGVVITDQRVRLLTEVLQGIRFLKFYAWEDFYAQQLGTLREREVYRIRLLGIARASLISILTFVPVLATVLSFITYALSGHELNVAIIFTSLQFFNIIRAPLMFFPMVLAASTDAAVGLRRMSRYLIAEELVDPYTIDPTSEHAIDVEGDFAWETADKSARKPKFDHSSRGEKDEKEKDKKEKREKKEKKKQNAKSGAKKGGFFGRKKEGDLLPTSAQADAHADDEKDDGEKAKEEVPFELKNLTLQVPKGSFVAVVGGIGSGKSSLLQAMIGEMRRNRGRTIFSSSVAYVPQTAWIMNATLRQNIMFGQPEDEEKLHEIIKACCLEPDLRMLPYGEETEIGEKGINLSGGQKARVSLARAAYSDADIILMDDSLSAVDAYVGKAILEECLLTGPLAGKTRVLVTHALHVLDKTDYIYIMDDGVIVEQGTYDDLMHGSLLFSRLMEEYGNLDKEEKEEDALGSKDEKPKTAGYEKQGSQAGQTPLMQEEERITGAVTYATYSRYLRFAGGLVWAPIIIGLLILVQGTQVGNNLFLGFWTAESIPGFHQGDYIAVYTAFGVASSIFAFLLSVAFTVATLFASLNLFKSALKAVLASPVSFYDTTPMGRIMSRLSNDQDTLDTEVSMTAFQLLYTFSSVIGTVALVFYTFPYLGLIFVPLTIFYYLAAIYYRRSSVETKRLDSLMRSALYAAYSETLTGLSTVRAYGAQRRFVKKSEEGLDLENRAYYMTVSIQQWLSTRLDVLGNILVLGIALFASGFRHTVSPSKIGVVLSYTLSITQTFSQLVAYYAQNEQNFNSVERVLHFTDLPSEGDMTTPNDPQPSWPDKGKIEFSNVELAYREGLPLVLKGVSFTVNPSEKVGIVGRTGAGKSSLLQALFRTVNVQGGSIKIDGWNIHDIGLQVLRRRLALVPQDNILFKGTLRENLDPQNTRSDAELISVLQRAWLLPRDGSHDPVAEAKFSLDCAVNDEGSNYSAGEKQLLALCRALVKNSRVIVLDEATSNVDAEMDAKIQKTIQAEFSSSTLLCIAHRLNTIVYYDRVIVMNEGKVQEFDTPLNLFDREDSIFRSLCNEANLTRQDIIRTRASVPDTSNPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ73</accession>
    <name>A0A401GQ73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615286.1">
        <property type="nucleotide sequence ID" value="XM_027759485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ73"/>
    <dbReference type="GeneID" id="38781290"/>
    <dbReference type="InParanoid" id="A0A401GQ73"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="205" mass="22536" checksum="1003C673AFD81BD9" modified="2019-05-08" version="1">MEHALWRLFAPPSPPHLRCLCYLLVIPPVLGVHVRIILAFRICITVELTGTDIVIIALSSIIAVVMSSVIVIIVCTLSGQCRLRRLTVGILLVTDSGYTMEHAPWRLVAPPSPPHLSSIDVIALSSIVIVIMSTIDTVMLSSIVIVVLSINAMFTLALVLSLTVLMVTSAFVLLRHTSALRLHKVKFPVRWGEDDYTIIVIIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQN4</accession>
    <name>A0A401GQN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0604490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615383.1">
        <property type="nucleotide sequence ID" value="XM_027759582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQN4"/>
    <dbReference type="GeneID" id="38781387"/>
    <dbReference type="InParanoid" id="A0A401GQN4"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="10889" checksum="16B9BB8B45DB7F11" modified="2019-05-08" version="1">MQNMDDSNWQNSKGQGVGGVYDQTRQAGQETMGGGHGSGVAGGPKGSEQKQSTQSSGQKNWPEHGTEAVGQKAGMNMSDQNAASASTFIDEETPEYCEGHGLPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR15</accession>
    <name>A0A401GR15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SCP_0606350</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615569.1">
        <property type="nucleotide sequence ID" value="XM_027759768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR15"/>
    <dbReference type="FunCoup" id="A0A401GR15">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GR15"/>
    <dbReference type="GeneID" id="38781573"/>
    <dbReference type="InParanoid" id="A0A401GR15"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="21" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="41"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GBE84656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="270" mass="30832" checksum="A2B07912CBA2B4D6" modified="2019-05-08" version="1">MSLLRSSVLRPQLLSSARAFSASVARRQAVPTEKPELNKEFKIYRWNPDEPAKKPMLQSYTIDLNQCGPMILDALIKIKNEIDPTLTFRRSCREGICGSCAMNINGQNTLACLCRIERDDGKDTKVYPLPHMYIVKDLVADLTLFYKQYKSIEPYLQNDNPPANREFLQSIEDRKKLDGLYECILCACCSTSCPSYWWNQDEYLGPATLMAAYRWMADSRDSYGAQRKEKLQNELSLYRCHTIFNCSRTCPKGLNPAAAIAKIKLDLATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR76</accession>
    <name>A0A401GR76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0602020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615137.1">
        <property type="nucleotide sequence ID" value="XM_027759336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR76"/>
    <dbReference type="STRING" id="139825.A0A401GR76"/>
    <dbReference type="GeneID" id="38781141"/>
    <dbReference type="InParanoid" id="A0A401GR76"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="137" mass="15123" checksum="421EBDC939AC7231" modified="2019-05-08" version="1">MALKRIQKELIDIRRDPPPSCSAGPAGDNLFHWKATLIGPSETPYEGGVFFLSITFPSSYPLKPPKVTFDTPVVHPNVFEGGSICLDILKEQWTPALTITNVLLSISSLLAENHDSESARQMTREHAMHRAGAQQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRK2</accession>
    <name>A0A401GRK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615693.1">
        <property type="nucleotide sequence ID" value="XM_027759892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRK2"/>
    <dbReference type="GeneID" id="38781697"/>
    <dbReference type="InParanoid" id="A0A401GRK2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12689" checksum="2B19BF43E5CE1BBC" modified="2019-05-08" version="1">MLSVTVFASYEFPHGHHQITDKLRSPFPPNKASAIRNIVPLSRDFHKLLDEGSCIIVPRALFFVECRNTALAGRFHDVIVRVPAHVDNYVLYLSFVHGVFCQTLPLYDLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRM0</accession>
    <name>A0A401GRM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Probable Na(+)/H(+) antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0700360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615769.1">
        <property type="nucleotide sequence ID" value="XM_027759968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRM0"/>
    <dbReference type="FunCoup" id="A0A401GRM0">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRM0"/>
    <dbReference type="GeneID" id="38781773"/>
    <dbReference type="InParanoid" id="A0A401GRM0"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="28"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="475"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="652"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="679"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE84856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="834" mass="91984" checksum="BE0145A00A3E0F29" modified="2019-05-08" version="1">MRFHPFQTTTPHIAYAVLGGFVVIFGMLSLFIREKLYMGEALLAFLFGIIIGPYGANIFNPRGWGGGNPDTVNTIVLEFTRVVLAIGVFAIGVELPKQYMKRHWKSLFFLLCPVMTWGWFVSAGLIYALIPGLNFLSSLAVAACLTPTDPILAAAVIGGKYADKHVPAHLRHLLAAESGCNDGAAFPFLFIALYLTLDSTTGRAIEDWFLVLWLYQVMLGVVLGALIGFGFRHLMKFCERKDLIDRQSYVAQYVSLAILTIGVCTLLGSDDLLAAFSCGTAFAWDGFFNKQTEEAVFSSVIDLLFNIAAFVFVGAWMPFHQFSDPELTLTPWRLIVIAILVLLLRRLPIMVALYRWIPDVKTFREAVFSGHFGPIGVGAVFISTLAAQQLPKPASPPEGQAQLLAASIQPIVAFMVLCSVTIHGLSIPFFSLGRRVHSVSRTWSRHDTFGTFSISRSGPLLPEWTTQTRRIVPGEDVVINRDSDTERGILRSPEKENVTPDSSVNQEGEGSRPPQGEKHVHMEKKQESGTREYPPDGTETVAEWKEGPHNIVERRTGPGSEVEVEVQRDAFGPRESASDTLRDAGDAAQSTIQNARQRIRRVPNDLEHLFERAEEGLQEETHEMERTVATAENRLGMEGAHEEEDEGWMSDTSDRRPEVSTSTEGKEKSRSRSPKKPGKLPSLRPTLTTTRRRSSIRRGVLAIRTSRRLSGSDAASRPPEDSDGEPSPETAGEHHSRPEVRPGSASRPSSLRHARVDSLRSSESPRSREHSPTRSVRFAISPTPSGYNSPRITSPSSPVTPLPGSEAPSEDEREVVDSPRAQVRFNLPTAGEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRN3</accession>
    <name>A0A401GRN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0603630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615297.1">
        <property type="nucleotide sequence ID" value="XM_027759496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRN3"/>
    <dbReference type="STRING" id="139825.A0A401GRN3"/>
    <dbReference type="GeneID" id="38781301"/>
    <dbReference type="InParanoid" id="A0A401GRN3"/>
    <dbReference type="OrthoDB" id="669841at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18945" checksum="A50EB1ECF900574F" modified="2019-05-08" version="1">MHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYVNPPPDVVDNEEEYEVEAILNHKTYRGHLRYLVKWKGYSSAENSWEPTHNLQNAKRILDAYKRTRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRU8</accession>
    <name>A0A401GRU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable guanine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0701550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615884.1">
        <property type="nucleotide sequence ID" value="XM_027760083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRU8"/>
    <dbReference type="STRING" id="139825.A0A401GRU8"/>
    <dbReference type="GeneID" id="38781888"/>
    <dbReference type="InParanoid" id="A0A401GRU8"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="62"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="468" mass="51207" checksum="71E07B5D83DF110F" modified="2019-05-08" version="1">MLFRGDLVHCPSLGELEIVHDHLLVIDDKGYVSHVVPSGSKVALQIIENASDPPIVIPRGSFLLPTFCDLHLHAPQFLYQGTGLHLPLMQWLDEYAFKAEESLDGDPDLAMRVYTRLAARLIENGTGAVLLFGTIKEETNLILAEVMQTAGIRAFVGKLSMDVSSRSSYVEESADAALSSARSFTEKCLELVNRLPEHDRLIAPVLTPRFVPTCTDALLKGLGDLSESRGLRIQSHMAEALEQVQLVKSDRGIDDIEVFSRSNLLTPRTVQAHCTFLDPPSLARVAECGTAVAHCPQSNAYFSAEPFPLREALHLGVKVGLGSDIAGGYSIDIMDCMRRAVAVSRMREGARVMGHTTMKLNDGSGELANLSVDWKETLYLATSGGAIALGLPSGSNTFTVGAPFDAQCIHLFEKDTGTGIGPLDFFHEHAEPLDEVELTNDMIEKWWCIGDVRNRGKTWVQGRRVAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRV4</accession>
    <name>A0A401GRV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Saccharolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0701280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615859.1">
        <property type="nucleotide sequence ID" value="XM_027760058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRV4"/>
    <dbReference type="STRING" id="139825.A0A401GRV4"/>
    <dbReference type="GeneID" id="38781863"/>
    <dbReference type="InParanoid" id="A0A401GRV4"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="221"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE84946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="679" mass="77371" checksum="484CBB56D5DAE85A" modified="2019-05-08" version="1">MASLNPPQAPPTWTHSAADVLALTKEAIARDRELNDRIGALTPADCNFTSVFAALAQGEAQIDSIVEPLSFYQNVSPSKELRDASNDAEVMVRDYGVDASMRLDVFQAKLAAEKNIKESNVKLSPEEIRLVEKMILDGRRSGLALPDKERDELMRLQKELSQTCLQFSRNFNEENGFVSFTLEELKGVPADVVSGYTKRTEGDKELYDVTFKTPDIFPVFKFAENPETRRIAYERREGRLDVNAPILSKALELRRQIAALLGYDNWADYITEVKMVKNSRGVIDFLADLEQKLRPVGLKDREVLLALKQEEHAEKGYPFDGEFYVWDYSYYDRKFIERSLDLDDQLVKEYFPVSFVVPAILEIYQSLLGVHFVEMKGETWHPEVQQFSVWENDAKDESGFIGFCYLDLFPRASKYSHAAVWPLLPGYQRPDGKRSYPLAAMVANLAKPTPQKPALMRHDDVVTFFHEMGHVFHGLLSRTKYSRFHGTSVARDFVEAPSQMLENWCFEPEVLKRMSRHYETQQPLSPELIDKIIKSRYVNVGLFYLRQLFFANFDIKVHTAKTSSDETELWNKLRESISLVKGGKPTTGQATFNHIASGYDAGYYGYTYSLVFASDMYATVFKKGPLDPALGQRYREKILQPGGSREELVSLEEFLGRPPNSEAFIKELFGHTSAASPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSQ4</accession>
    <name>A0A401GSQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0703850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616112.1">
        <property type="nucleotide sequence ID" value="XM_027760311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSQ4"/>
    <dbReference type="GeneID" id="38782116"/>
    <dbReference type="InParanoid" id="A0A401GSQ4"/>
    <dbReference type="OrthoDB" id="3157337at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="98"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="527" mass="56177" checksum="24BC7E7E7BC8B650" modified="2019-05-08" version="1">MDAVDIPNLAAVQLNDPTPLPDAAQTEAQVDHHGVTPVSEIEPPRKRQRTANVLEAPDSTSALMSGSTTESMLGAEPKTGAGLLPEPVRDEAYYIDCADCVIRVENTLFRVHRFLLARDGSAFQDMFTLPPPTAGGEGASDAHPIVLWDERASDFRLLVSVLYALPSELQAYTAPGASLPRLLTLVHMTHKYHFLTTEAWALAALHGAFQQAVAQQQQQRALTSRTLSRTLDVALRADHTRLVVGAAEAWTARVRTRALPAACALAFVDAHPYAGWAPPQSVGEGVGADVARALWAFRSAAHYVALMEVQTDFTLPGPPAAPSSPASIAPPALSSAPPDARIHAEDAEEEDGPPPVLTPEQKRRLLSGHFALARRWAALCAGAPPGFARPEGCTYHVRGCVETWAGAWRDALGAAGGSGDAADVLGRLGAVERAVEGSAEVRVGLTPACRREALGALRRWRGEVEEWVGGCYSPIVEHGSLPKTPGGSVSKRHVDTPEHMDDGPQELEGRRRLYDAALHAAQASIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSV3</accession>
    <name>A0A401GSV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0704730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616199.1">
        <property type="nucleotide sequence ID" value="XM_027760398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSV3"/>
    <dbReference type="STRING" id="139825.A0A401GSV3"/>
    <dbReference type="GeneID" id="38782203"/>
    <dbReference type="InParanoid" id="A0A401GSV3"/>
    <dbReference type="OrthoDB" id="3044497at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="17890" checksum="41993C3B53BB1772" modified="2019-05-08" version="1">MHTRGVPSQIINWLKRHLEGRRTRILFNDFRSALFEIINGIDQGCPLSVILYEFYNSDLFEIAYRIPQSLALGYIDDAAIIAIGKDFEETHTILCSYMDDERGTMAWSTTHYSEFSLEKFGLLNMSATPHELGPTLELCTASIKLAELHKFLGTIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTL4</accession>
    <name>A0A401GTL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0800470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616443.1">
        <property type="nucleotide sequence ID" value="XM_027760642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTL4"/>
    <dbReference type="GeneID" id="38782447"/>
    <dbReference type="InParanoid" id="A0A401GTL4"/>
    <dbReference type="OrthoDB" id="2980978at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="183" mass="20331" checksum="DE7A0903D26859C1" modified="2019-05-08" version="1">MPSSATAFYSDDESDYEDDDSLVENEDTRGYDSPGEGQENSAGSDDRQRTASSTPHQECTRKLKVNLKASGDIAECVVRVLEFMDSEDINLPLFLWALSWNPAIPELISNGKARYARTSLMVSEELPMILRHWYRPPRTHGTGVRIKAGGAVFQEFALEIVNERVQSDMRTEASDALASGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTV4</accession>
    <name>A0A401GTV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0703500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616077.1">
        <property type="nucleotide sequence ID" value="XM_027760276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTV4"/>
    <dbReference type="GeneID" id="38782081"/>
    <dbReference type="InParanoid" id="A0A401GTV4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8058" checksum="31C530D4CD81B2E0" modified="2019-05-08" version="1">MANRGPPSISDLQNQIRALSADVSQTEAIALKVQRAVEIIRAALGINTGGASPSVPPSTVPPSTAPPSAAPPFSNVTEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUC4</accession>
    <name>A0A401GUC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Asparagine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0705210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616247.1">
        <property type="nucleotide sequence ID" value="XM_027760446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUC4"/>
    <dbReference type="FunCoup" id="A0A401GUC4">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUC4"/>
    <dbReference type="GeneID" id="38782251"/>
    <dbReference type="InParanoid" id="A0A401GUC4"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000016">
        <property type="entry name" value="Asparagine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="138"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE85334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="461" mass="51655" checksum="A1CB979821A8AE6C" modified="2019-05-08" version="1">MIFRRFLSTSLPPTIRQLLSSHVSAPVEVTGWVKSVRRQKNIAFAVISDGSSDRGLQAVFTNTDLAKSLTNGASVRLGGKLSDSPGARQDKELQVDSVEVLGDCDPSTYPIQKKILTVDYLRDHCHLRARTDTIASMLRLRDHAQRVLHHFYETQGFCYVHTPILTSSDCEGAGETFGIAASSHPEHASAQRSDFFGLPAYLTVSSQLHLEAIATAISRVYTLSPCFRAERSQTGRHLAEFWMLEAEWAFTRSVDDICRFVEASLKDLLQNSRDAMAPLWNDHDHPGAAVLQAAASSTEWVRISYSDAVTELEAHQRATRAFAFDPGWGKPLQSEHERWLAETLVRGPVFVTDYPAILKPFYMRMNDDGKTVACFDLLIPHMGELAGGSLREERHEVLKEALNQHNLPEDEYGWYLDLRMYGGAPHGGFGMGFERLISWMSGIENVRECIAMPRWSGRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUE8</accession>
    <name>A0A401GUE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ste24 endopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Prenyl protein-specific endoprotease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SCP_0803320</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616723.1">
        <property type="nucleotide sequence ID" value="XM_027760922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUE8"/>
    <dbReference type="FunCoup" id="A0A401GUE8">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUE8"/>
    <dbReference type="GeneID" id="38782727"/>
    <dbReference type="InParanoid" id="A0A401GUE8"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 21" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="686"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="727"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="20">
        <location>
            <begin position="417"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="19">
        <location>
            <begin position="605"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="328"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="674"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="760"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="673"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="756"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GBE85810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="832" mass="93999" checksum="5EE9BE426649AC5F" modified="2019-05-08" version="1">MIPQSRKRKHKFHSRPYGDHHATTSNDAEGPDPALFIQAYEADITRGPQAVAAAQSLEVEYADGGTRVAQIGDGLIRWNGNQSRGESMEFEEDSVYLGHREDNSSKAQPEEDQDAIWVDRYDARLLLDTLPLAPTPAVTAEPSSPTGWSDLPSDAEDTFFFTQEEAEDYGREKRRRLFDRNREERLKALRAEERDDEEVKQEEWGGSDEEPDDRQRELMQRTAAHVLSSPNPAQLEMRILANHGADRRFAFLRGRWSRTWKTAKSRVRLEMENENAEKLKQARLGSLGGLAGYGDSDEDNDEEAQSLHEAEGAEETKAIVLVDTGSAAAGAPDADDDVRRARRARAKEWAEKRRASQANGEHSGSPGHLDMDILNTQLDALQKRLAFVAVDPIDWRFYVQAFSWGVCLFESYLLLRQYPLYSKKAPPPSLADHFTADVFAKSQAYGKDKARYQLVSGLYHQAVQSATIQYGLFPWTWEVGGRLLKFGGYGPEHKILHSIAFVLVLSFVSSLPGLPLSIYETFVLEQKHGFNKVTPGLFVADLLKGWAIGLVILPPFLGVFLYIFDWAGDRFIPWLMAFLLAFQLIMVVIYPVMIQPLFNKLSPLGEGELRSRIESLATKLKFPLTHLYEIDGSKRSSHSNAYFYGLPWSKHIVIFDTLIKQSKPDEVEAVLAHELGHWYYMHPSKLLIVSQLHIFTILALFPAFLHAPPVLRSFDFSKAIAADPPTILAFFLFQNIIMPIEAVVGIAMNAVSRRFEYQADRFACELQTMLKEQSMSDMGDRLGRALITLHVKNLSTVWVDWLYSAYHHSHPTLTERLKALEGFGAGAEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUM8</accession>
    <name>A0A401GUM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0706210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616347.1">
        <property type="nucleotide sequence ID" value="XM_027760546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUM8"/>
    <dbReference type="STRING" id="139825.A0A401GUM8"/>
    <dbReference type="GeneID" id="38782351"/>
    <dbReference type="InParanoid" id="A0A401GUM8"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="379" mass="43619" checksum="6BB57F5AC6AAB51C" modified="2019-05-08" version="1">MVSHQSGNKSNVNLPSYVFCSPDQVQYYAEETRKGMYALYEGEIFWRDRQPYLDEHGYSLRPRYHPNWTPSWQETNLDPVFCEDSIALRIDVVIDATRKADGKLVSIKTVKRNGGEVRIASYLSRPDVSSHPLNRCVRILDVFADPFDQDAAFMVMPYLRPFDDPDFGAIGEVTEFVRETLEGLTFLHSQRVAHRDCAAANIMMDGAPLYPQGHHPVRRESSPDGIYLLSPLSRIDHPVRYYFIDFGISSLFEEGESPFVVGRKGRDKELPELSDDVPYNAYKVDIFILGNLYKKDFLQKYYGLEFLDPLIRAMTARDPAHRPDAEVALTIYHDIRRGLNPPLLRWRLRPRDESAPERILYDSVAAAREGIYRLKHIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUV5</accession>
    <name>A0A401GUV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616886.1">
        <property type="nucleotide sequence ID" value="XM_027761085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUV5"/>
    <dbReference type="GeneID" id="38782890"/>
    <dbReference type="InParanoid" id="A0A401GUV5"/>
    <dbReference type="OrthoDB" id="2753953at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="370" mass="41686" checksum="187E49639E1AFA34" modified="2019-05-08" version="1">MATSIFKGSMRDPFPHSNFCLSLHLMANIPIDPVLLHEEASVNPPSVLDLITEIQANNSTAPATPPSHASSPDPEEEDQAQEHLSEDQPHGTRRTREEYEGENTRYGERLDAVEFGQRLKRQRNLTPHSESELARFAESPHLLQHTMYTYGLLLECRDYLQKLSRDSEYKIPDTLRATLTDYVHTYILSPTIESYCKASNPGNILAAMRHLNIAQIPPEQETGRCAVIRTVVAKGLTEWRNHVKTQISISIDAKSTIRNLAALAHACIKTCSARPTVAMYIRLAYIRLIFVKFSGLKEDAFWNKVDSSMKEIREQYRTSGAIYDAYQAVYRNDKLTYGEPDNAMYPIALATSIPAFINDLNAASNSRGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVP6</accession>
    <name>A0A401GVP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617211.1">
        <property type="nucleotide sequence ID" value="XM_027761410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVP6"/>
    <dbReference type="GeneID" id="38783215"/>
    <dbReference type="InParanoid" id="A0A401GVP6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="11427" checksum="63EAADB54FBC51FA" modified="2019-05-08" version="1">MHKDPPSISISISPPNLIHPGRMLTYASPPRAESESPLVSSAPVKFGRCASNSPWGIPPGEIKKSRSEARVGWVRAGRDLASHVVRWCSRLRCGLGACGQVDLAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW95</accession>
    <name>A0A401GW95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWI/SNF and RSC complexes subunit arp9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0903750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617409.1">
        <property type="nucleotide sequence ID" value="XM_027761608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW95"/>
    <dbReference type="FunCoup" id="A0A401GW95">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW95"/>
    <dbReference type="GeneID" id="38783413"/>
    <dbReference type="InParanoid" id="A0A401GW95"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10208">
        <property type="entry name" value="ASKHA_NBD_ScArp9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="502" mass="54486" checksum="85F25991FBA18F54" modified="2019-05-08" version="1">MSTFRDPVVVVLDTGRTIIRAGIGIFDLLRPPTVEISARVGLRSTAPDAENGAPEPSGPQPGPSTSKSPSTAKVTDYLVGAQLDEAVAAGHDIAIFWPFAEGDIADWTQAEALWKYVLFKQLQLRRAQMESPVLLSILPGLSRDAYERICQIFFERFNVAGFGILDRPVAQFYAVISGNQLSGVIVDIDRDHTDITPIYDGFVQHTARTSTPLGLRDCQLYLAHLLHSNQSVVAALSPPASPLSPEALQPVLLELAEHIWQEGLIKALAEGEAARDIEEEGVTDIAAVLVAGKEKAVIESGMKKKANAKASAAEQARAREIEALDLVTVQFRGHTLTVGKERHRFCEPLFDPNLLTSLPGIEPKARKDVPILPIQTAVGEAVGRTEVDQRAYIWQGLFVTGEITNHIKGLGAALQGRLASFILTSPDPQQNEVQPRIIRVLKVPDYFAEYREKGDGLASFLGTSIVAKITFIDMTGGKNFVSKTDYVSTGPRTILGMSPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWQ0</accession>
    <name>A0A401GWQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0904780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617512.1">
        <property type="nucleotide sequence ID" value="XM_027761711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWQ0"/>
    <dbReference type="GeneID" id="38783516"/>
    <dbReference type="InParanoid" id="A0A401GWQ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="11111" checksum="E4F98D056FEB944E" modified="2019-05-08" version="1">MEYPHPLLARHQNQFPFDLALLVRTYPVDDLRYPNHLSRPHPLLRVAVIPTGMDASTNKDHEPAGGHATDVEEIIMSATAPDDDEDHKISCRTKMLDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWU7</accession>
    <name>A0A401GWU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed RNA polymerase II subunit rpb4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0905290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617562.1">
        <property type="nucleotide sequence ID" value="XM_027761761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWU7"/>
    <dbReference type="FunCoup" id="A0A401GWU7">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWU7"/>
    <dbReference type="GeneID" id="38783566"/>
    <dbReference type="InParanoid" id="A0A401GWU7"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="15240" checksum="B507083D4952BEBA" modified="2019-05-08" version="1">MATPRLRHRPQTEEEDAASLKLGPEFNNAGCLLISEVKYLLENRDKDAPDTAVYNKTLEYVKTFAKFNTTDSASAVREILRREPALTQFETAQIANLCPANAEEAKSVIPSLVKLDDDRLQQLLDEIQTTRKFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX72</accession>
    <name>A0A401GX72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 20.9 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0902430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617277.1">
        <property type="nucleotide sequence ID" value="XM_027761476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX72"/>
    <dbReference type="STRING" id="139825.A0A401GX72"/>
    <dbReference type="GeneID" id="38783281"/>
    <dbReference type="InParanoid" id="A0A401GX72"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="99"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="164" mass="18813" checksum="2969B1D32CE31081" modified="2019-05-08" version="1">MPEKVVQTPYPLIDADPHASRVLRYFRATDYGVWAAATAAFPAALYFWDVADPSKVKLRTHLRLGGMLGFIGGFLLAYQRSSFRFWGWSENKREEELDRVELTERAAKGLPLYGESNQPEWVQGAAYRNSAFSQLKFQAFPMFNLVNHQHHGTDPEKYKPKNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYF4</accession>
    <name>A0A401GYF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Urea active transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1004670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618133.1">
        <property type="nucleotide sequence ID" value="XM_027762332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYF4"/>
    <dbReference type="STRING" id="139825.A0A401GYF4"/>
    <dbReference type="GeneID" id="38784137"/>
    <dbReference type="InParanoid" id="A0A401GYF4"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="21404" checksum="F05830B12BA33F42" modified="2019-05-08" version="1">MPEAGVSEFKPLLDKSVGYGVVVGVGFFFAALMLLLTTLQKKFSNFTPSSSEEFTSASRNVKPGLVCCGIVSAWTWSATLLQSSTGAYTVGVSGPWWFAVGGTVVMALFAMVAAKVKMNANGAHTFLEIAKMRFGTVIHLLFTFYAFLSVLLISGCLLLGGAATVNALTGMNIVAACFLLPVGIAVYVIFGGLRRSSRYLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYW0</accession>
    <name>A0A401GYW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1100170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618255.1">
        <property type="nucleotide sequence ID" value="XM_027762454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYW0"/>
    <dbReference type="STRING" id="139825.A0A401GYW0"/>
    <dbReference type="GeneID" id="38784259"/>
    <dbReference type="InParanoid" id="A0A401GYW0"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="74"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="163" mass="18606" checksum="AF9B692688174084" modified="2019-05-08" version="1">MLIITLLFSSVQRQTWVPFFDDVHAIIFLAPISCFDQVLAEDRSVNRLEDSVLLWKAVCANKLLARVDLVLFLNKCDILAAKLAAGVRLAKYVRNFGERANERDVVEKYFRSKFMAIHREYSPVPRKFYGFCTSVTDSTTTGGIIASVRDMVVREHLRASKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H009</accession>
    <name>A0A401H009_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1104340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618670.1">
        <property type="nucleotide sequence ID" value="XM_027762869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H009"/>
    <dbReference type="FunCoup" id="A0A401H009">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H009"/>
    <dbReference type="GeneID" id="38784674"/>
    <dbReference type="InParanoid" id="A0A401H009"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="477" mass="51522" checksum="7903998B2FE44970" modified="2019-05-08" version="1">MVNVTYDASGDINYYDPSTGTTYVYNNGDIAWVLCSTALVWIMIPGVGYFYAGLLRRKNALSMIWASMMCVAVVSFQWFFWGYSLAFSDSADRYIGNLRYFALKGVLAQPSVGSARIPSLAFCVFQLMFAAITPMLAIGAFAERGRLGPMMVFVFVWSTLVYDPIACWTWNPNGWSFVLGGLDFAGGTPVHISSGSAALAISIYMGKRRGYGTERLAYKPQNTTYVVLGTIFLWFGWFGFNGGSALSANLRGIQACIVTNLAASVGGITWMLWDYRLERKWSAVGFCSGAISGLVAITPGSGFVGSPAAVLFGFMAGTVCNWATQLKFLLGYDDCLDIFASHAIGGIVGNILTGLFAQASVADFDRITTIPGGWLDHHWRQLGIQLADSVSGLSYSFVMTTIILWLMHYIPYMRLRGTEEAEITGIDDAEMGEFAYDYVGFDLAASGGHADGEAPASAPVPASVDASVADEKQGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0D5</accession>
    <name>A0A401H0D5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1200990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618787.1">
        <property type="nucleotide sequence ID" value="XM_027762986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0D5"/>
    <dbReference type="GeneID" id="38784791"/>
    <dbReference type="InParanoid" id="A0A401H0D5"/>
    <dbReference type="OrthoDB" id="2742985at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019528235" evidence="1">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="133" mass="13901" checksum="7987C3A6E6EBD508" modified="2019-05-08" version="1">MLSLQFSQALPTTLVVALLLASLANADFHNFNCGEAVGACSQLYNNGEAIAVPSNQYDCNGAENAPVFDGTNGVSDESPQYESFSITNFCGTNIDFYPASDGQTIPFYISGGDGTVQGTCYPGSGDKMSCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1R0</accession>
    <name>A0A401H1R0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1301480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619246.1">
        <property type="nucleotide sequence ID" value="XM_027763445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1R0"/>
    <dbReference type="FunCoup" id="A0A401H1R0">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1R0"/>
    <dbReference type="GeneID" id="38785250"/>
    <dbReference type="InParanoid" id="A0A401H1R0"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="313" mass="33616" checksum="132EB40DE52CA244" modified="2019-05-08" version="1">MGATRAQKELYFIKLKELIAKYSSIFVVNVDNVGSNQMHQIRVALRGKGIVVMGKNTMVRRALRSILSEYPQFERLLPHVKGNIGFVFTSGDLKDVRDLITANKVAAPARAGALAPKDVSIPAGNTGMEPGKTSFFQALGIPTKIARGTIEIVSDVKVVTAGTRVGPSEAMLLNMLNISPFTYGMTVIQIFDQGNVFTPDVLDVTDKELIDRFLSGVQTIAAISLALHYPTLVSVMHSLVNSYKNLIAVSLATDYTFEGAEKAKEYLANPDAFAAAAPAAASAEAAPAAEAAPAKEEEKEEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H259</accession>
    <name>A0A401H259_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Complex I intermediate-associated protein 30, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1303430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619440.1">
        <property type="nucleotide sequence ID" value="XM_027763639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H259"/>
    <dbReference type="STRING" id="139825.A0A401H259"/>
    <dbReference type="GeneID" id="38785444"/>
    <dbReference type="InParanoid" id="A0A401H259"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="5">
        <location>
            <begin position="39"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE88527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="262" mass="29339" checksum="25DF070E24440226" modified="2019-05-08" version="1">MSRLAQYLNRSSKLLRDSTSRMLRMSGADEPSRAPLTLFNLNSREDLQQFATGCDVDIGGLSTVHFDLDESSVLPGPNQTEVRRPTARFSGEMSLGVRSGLQGKIRGGYAGFRSKPRPTLFGEITNDVSNHQFLAMRLRVAGHPRTRNSYYVNIQTDGPITTDLWQHRLFFHRDDGGWEDIFIPFSDFVLTNVGEVSPEQIKMFRERVRTVGISMLGGNNGVSGPYELGVDSFRAVNHEDMPLAAIPKVEPSKGTQWERHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H270</accession>
    <name>A0A401H270_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1303530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619450.1">
        <property type="nucleotide sequence ID" value="XM_027763649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H270"/>
    <dbReference type="STRING" id="139825.A0A401H270"/>
    <dbReference type="GeneID" id="38785454"/>
    <dbReference type="InParanoid" id="A0A401H270"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="33"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="127"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="39224" checksum="57E863C067CB6DD0" modified="2019-05-08" version="1">MKVLAILYKGGEAASNEPRLLGTCENQLGIRQWLEAQGHEYIVSDSKEGPNSDFQKHIVDAEVLITTPFHPGYLTRNLVDKAKNLKICITAGVGSDHIDLNAAVEKKIQVLEVSGSNVVSVAEHVVMSILLLVRNFVPAHEMIERGDWQVSEIARNAFDLEGKVVGTIGAGRIGYRVLQRLVPFDCKELLYYDYAPLHQHAAAAIKARRVEDLKDFVSQCDIVTVNCPLHEGTRGLVDAELLSHFKKGAWLVNTARGAICDKDAVAAALKSGRLSGYSGDVWNVQPAPKDHVWRTMKNPLGGGNGMVPHYSGTTLDAQARYAAGTKSILENYLLGKEQEPQNIIVGIGKYETKAYGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2B7</accession>
    <name>A0A401H2B7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1304140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619509.1">
        <property type="nucleotide sequence ID" value="XM_027763708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2B7"/>
    <dbReference type="GeneID" id="38785513"/>
    <dbReference type="InParanoid" id="A0A401H2B7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="143" mass="15738" checksum="BAD54A20251B31DB" modified="2019-05-08" version="1">MKGSIEPVTVTSRMPSLAALPDELPIHRPTHWEQVPGLFPDTTQLLPMAVPGETNAASGSQVARLGRSFAQIAAEADSSMDDDEGDSFAVSRRRAMLRERIVRLQCELNLTEDMHVANLNASSTVFQMGYILRDIRGEAYHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2C1</accession>
    <name>A0A401H2C1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1303980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619494.1">
        <property type="nucleotide sequence ID" value="XM_027763693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2C1"/>
    <dbReference type="GeneID" id="38785498"/>
    <dbReference type="InParanoid" id="A0A401H2C1"/>
    <dbReference type="OrthoDB" id="3261578at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50117" checksum="7F4F7BC6235EB5AD" modified="2019-05-08" version="1">MDAPAYPGNAAAIDLELPSYARTPSTSWDVPPLNTQHSFHLTKKDGEHWLSLTVVSRAATNVETPMFFQGGLVGGTLMLNLEKEDIIDSVHIALTGQLNYFSHSASYFLNMKRTLWSCSVDQDPEVLADAPNTVKQSGKLKGRYEWPFSFKLPKGVSIVSHIDVDSARKNFRLPPSLSDGISGVRVEYQLAVRVERGRLRSHSKLVVPILFNPLLRPTTPSITRQLAYRENFPLVGADGDPEGWKTLPPVKLRGKIFKSIAVEAACTLSLARPLCYTRGTPIPLMLTIESADQQALDLLATRHAIVVRLVQRTSFGTTMPGFRETSAEEQPLKEVRSRSIGRAVWWPPENEVQLPNRRTLAGEIHIPEAVSPRCHILNFNLDHMVVIEPFQAVGFIPSEKKPLLRESVEIVTAFAEGPRPRAYMPPHYDGEDLEEPRPVGVRVGGFLVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2D4</accession>
    <name>A0A401H2D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1304130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619508.1">
        <property type="nucleotide sequence ID" value="XM_027763707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2D4"/>
    <dbReference type="GeneID" id="38785512"/>
    <dbReference type="InParanoid" id="A0A401H2D4"/>
    <dbReference type="OrthoDB" id="3251181at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="316" mass="34681" checksum="AF475DE04DD5D7A6" modified="2019-05-08" version="1">MSLKTETPTNTHLNIVPKLATDGSNWITYKEQIHTVMGSRSLMRHLEGTARRPPDPLPYPQTAPSAAAVTVPSTTAAMTGTSATAATTTTAPTQPALTPEEYLAKVEAAESKLDNFLQKEFAARQQIYGTINDALLLRVKKLPTAADVWGAIQKEYEGKSEMYSGAVRTRLQNMKCDEGANIRTHLDQMLKFREELSSMGAVMADADFSACIYTSLPSSYGTLLTALTTAACLSKNTLTSDDVVFAICEEFDRRSQGQTSETALFVKPARKFALRGKGQKNSKDIECFNCGRRGHMKLECWPHLLVMLPELNSHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2J0</accession>
    <name>A0A401H2J0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1400520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619560.1">
        <property type="nucleotide sequence ID" value="XM_027763759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2J0"/>
    <dbReference type="STRING" id="139825.A0A401H2J0"/>
    <dbReference type="GeneID" id="38785564"/>
    <dbReference type="InParanoid" id="A0A401H2J0"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="161"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE88647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="247" mass="28054" checksum="03FE506A859DEC9F" modified="2019-05-08" version="1">MDDTAIFGRLVEKFSAKSSEVDMENYGNEILQTLMDLESEMKPDPYYIDKQIQMDWSHRSTLIEWIAEVHQRLHLVPEMLFLCANCIDRFLSCKTINIERLQLVGITALFIAAKYEEVRPPPITDMIYWADDSCTDTELKSAERMMLSKLEFQLGRPSPIDFFAWIGQTGGYSPKAHAVTQYFLEVTIIDACFLNHPPSLIAGGAYALARIMLSEDSQVRSVHCWVAASLTRALVPSSYLLSGIHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2M2</accession>
    <name>A0A401H2M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619590.1">
        <property type="nucleotide sequence ID" value="XM_027763789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2M2"/>
    <dbReference type="GeneID" id="38785594"/>
    <dbReference type="InParanoid" id="A0A401H2M2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14432" checksum="45F3790F580A3307" modified="2019-05-08" version="1">MAVVTCSAATASFDVSDEDLTKFQEHTGISKQVYKRVIAALQAYAEKHGPMPLMAYTDHEVEINDFTNKFSQSAGTKLGSIELVLIVANGLWAIERGDQEQAVSAGLGMNVPVAIGTEGTTEKCKKHNFELRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2M5</accession>
    <name>A0A401H2M5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1400570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619565.1">
        <property type="nucleotide sequence ID" value="XM_027763764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2M5"/>
    <dbReference type="GeneID" id="38785569"/>
    <dbReference type="InParanoid" id="A0A401H2M5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="93" mass="10521" checksum="0EE9EFC6D4726D41" modified="2019-05-08" version="1">MADTEDGHSRDNSDTATVIEEGTSSEHQHHSGQTINLNDFFANISFPFRFDRRREDFRAPDMVWTQVPRTASPLPARGRTGAAPLRFREVHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Z4</accession>
    <name>A0A401H2Z4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1402200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619728.1">
        <property type="nucleotide sequence ID" value="XM_027763927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Z4"/>
    <dbReference type="STRING" id="139825.A0A401H2Z4"/>
    <dbReference type="GeneID" id="38785732"/>
    <dbReference type="InParanoid" id="A0A401H2Z4"/>
    <dbReference type="OrthoDB" id="3144234at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="134"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="304" mass="34224" checksum="9C2A7B1841F5EAE9" modified="2019-05-08" version="1">MTYVAPDKGFIKYMAPPFEATNYFPPQILLTMPSTSKHVRFREPCEEDQSPLPPMMASSPSSSRSSMDSPTLRTPPDYVTPVSLPYIPRHAHPFPSQTNLWGSPFAQARAAPLPYSPYLHPLLTSAHPQYPCSLEWDLRQSPDHARFRAPNGQYLHLTDEQLAASATFPPRSSLLIVCEYLAWSIDVSIVPQAAWSPPPRVRGARPPDPYVTVGDVLYCLYRNLRNSVRSGELRWAEESGTYVRVEGAFKARATTVDDARKGIRRVDCLMEMSRFAGLSLVAYHPQMEGDSRKEVGQVWSLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Z9</accession>
    <name>A0A401H2Z9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619685.1">
        <property type="nucleotide sequence ID" value="XM_027763884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Z9"/>
    <dbReference type="GeneID" id="38785689"/>
    <dbReference type="InParanoid" id="A0A401H2Z9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="18330" checksum="818BF24091E0057E" modified="2019-05-08" version="1">MDRRQGSSLTSDGQGKGYGKHLSSQDESKCLQKALSSMGARLAKAEKQRQEKGKEHHRFLYTSFILLDRIRDLVATSCGFEDSSWMHMLYKMEKEPDRDWAKYAQESLAEISDDEIPLEIPLEELRYILTDLHDPPDIDRIPTLVRWRNDFCKEHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3V1</accession>
    <name>A0A401H3V1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">60S ribosomal protein L41</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1500860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619996.1">
        <property type="nucleotide sequence ID" value="XM_027764195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3V1"/>
    <dbReference type="FunCoup" id="A0A401H3V1">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3V1"/>
    <dbReference type="GeneID" id="38786000"/>
    <dbReference type="InParanoid" id="A0A401H3V1"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="106" mass="12260" checksum="0F9A13230AA8D7F7" modified="2019-05-08" version="1">MVNIPKTRRTYCKGKQCRKHTPHKVTQYKKGKDSLAAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTVCKYKMQLSLKRCKHFELGGEKKTKGAALQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4G3</accession>
    <name>A0A401H4G3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620215.1">
        <property type="nucleotide sequence ID" value="XM_027764414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4G3"/>
    <dbReference type="STRING" id="139825.A0A401H4G3"/>
    <dbReference type="GeneID" id="38786219"/>
    <dbReference type="InParanoid" id="A0A401H4G3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="81" mass="8691" checksum="C70AA850731FF70B" modified="2019-05-08" version="1">MGRCLCVCSTHVSIIIIKGNATDTAVLCFSEALSIPSLDIDTASLLSSHDKLFEIPFNSKDRWMPTVVRAHSTVAGSPAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4G4</accession>
    <name>A0A401H4G4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase C-terminal-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620153.1">
        <property type="nucleotide sequence ID" value="XM_027764352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4G4"/>
    <dbReference type="STRING" id="139825.A0A401H4G4"/>
    <dbReference type="GeneID" id="38786157"/>
    <dbReference type="InParanoid" id="A0A401H4G4"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="233" mass="25664" checksum="B916C481232362DC" modified="2019-05-08" version="1">MPESITLYTAKICPYAQRVELALEEAKAPYTKFQINLQNKPDWYAPLVNPASKVPAIAYGGPAVAADQPSPKSTKLTESLVLIEFVADSFPDGHLLPADPVLRAKARFFIDVVSTKFVPAWSAFVSGKGTADAFVSATEQVTALLPETGFAVGEYSTADIAVTPFLARALTALKNDLGLYPAGEGKKLYDLFHTPRFERLQKYWRDVSSRPSFKATFDEAYIVEKYSARFARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4I3</accession>
    <name>A0A401H4I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620269.1">
        <property type="nucleotide sequence ID" value="XM_027764468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4I3"/>
    <dbReference type="GeneID" id="38786273"/>
    <dbReference type="InParanoid" id="A0A401H4I3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="78" mass="8707" checksum="BF05F22E5EF51DC8" modified="2019-05-08" version="1">MVPMVPADQEERVPAPPAPPSDDLSPASSSNGIFVPRHVHEARLWVYEPAGVYLRNTSRSDQACIEYRQMVKTCCHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H511</accession>
    <name>A0A401H511_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1601890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620440.1">
        <property type="nucleotide sequence ID" value="XM_027764639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H511"/>
    <dbReference type="STRING" id="139825.A0A401H511"/>
    <dbReference type="GeneID" id="38786444"/>
    <dbReference type="InParanoid" id="A0A401H511"/>
    <dbReference type="OrthoDB" id="3357985at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019351004" description="BTB domain-containing protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="54"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="253" mass="28281" checksum="3B8F1A7C8B36E234" modified="2019-05-08" version="1">MDSIGNRSNRCSASSLLGIVLLLISRASPTQPDEVHSSFHPFHDAPSPFNKPTADTILRSADLVEFRVRKSILIEASSPFEGMFSLPQPPIGDDQSGDTQAEGGLESRDGLPVIPMAEDSRTIEKLLRICYPGRHPAIDDLMTLRTLLAAATKYVMDEVTEVLRDALCAFAQTMPLQVYAFAIQYRFEKETREAARRFLNHKFVLENVPELANIPASAYCRLLTYRERCSQIARESQDAIRKLTFADAAFARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5B0</accession>
    <name>A0A401H5B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1602890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620539.1">
        <property type="nucleotide sequence ID" value="XM_027764738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5B0"/>
    <dbReference type="FunCoup" id="A0A401H5B0">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H5B0"/>
    <dbReference type="GeneID" id="38786543"/>
    <dbReference type="InParanoid" id="A0A401H5B0"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE89626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="476" mass="51392" checksum="CD1F348478D9F867" modified="2019-05-08" version="1">MAPALTTEPTQAATGAKPSPRPTAILHRTPWIPPVATHAEGIYIYVEDGRKIIDGCGGAAVACIGHGHPAVKKAIAEQADKLSYVYNMQLSNQPAEELAQYLVKTGNGAFELCGFLSGGSEAMESAMKLARQYYYETKQPQRTNFIARQLSFHGNTLSTLSLANHPARRAPYAAILDQTHFHHVSPAYAKRFQKPDETEEQYVERLRKELEDKFIELGPDTVIGFVAETVVGATSGVVPAPKGYFKAMKAVCEKYGALFILDEVMSGMGRLGTLHAWESLGDGASPDIQAIAKGLGGGYASIGAVLMSRRVASGIRDSSGYWKHGHTYQAHPLSCAAALAVQKVIVEENLLENIRTQGAYLGSLLRERLESPNALAAPFVFDIRGAGGWWSIEFDFTGPEAAKLDFKAEKFGLVVQARCLENGLAIMGMTGGSNLEGTLGDHLMISPPYNVTKAEVERIVDILVASVEEILKEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5D6</accession>
    <name>A0A401H5D6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1603210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620570.1">
        <property type="nucleotide sequence ID" value="XM_027764769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5D6"/>
    <dbReference type="GeneID" id="38786574"/>
    <dbReference type="InParanoid" id="A0A401H5D6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="11487" checksum="866C42A0EE9C224C" modified="2019-05-08" version="1">MNGTIALRGRHYKTVRSIFQAQGSVGWRELVEAFQSMSFKVKATKGSVHKFSPPSTIPGRAFTWHKPHSSQLRPDHLRILRGDLSQLYHWRVETFVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H637</accession>
    <name>A0A401H637_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620811.1">
        <property type="nucleotide sequence ID" value="XM_027765010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H637"/>
    <dbReference type="STRING" id="139825.A0A401H637"/>
    <dbReference type="GeneID" id="38786815"/>
    <dbReference type="InParanoid" id="A0A401H637"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="1">
        <location>
            <begin position="211"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="974" mass="109476" checksum="23B15E3A139BDC2F" modified="2019-05-08" version="1">MEGSAAGYKDKGNVAFKAGSMAEAAKLYAKAEKLDRSDPVYPSNLSAALYEMGDYLGSMNAILRSWRLLRSRSDSKPDLILRLSIRLAKALCNGFRSGAISQGVLEEHVTDTKDVEETALEQPSTSSNAAASEEVVRVWKDWRQMEPDIAGHDVAAHRSLSKFSHFSIYTKTMDPTLEFYSIGQDDVMSILEGWGPHDRYPLKLSDLSSDRLSNLAFFFGGVGDARHIHGSLIGLHHAFQKLNKPKRSKLHVHMTLLDIHPAMLARDLCIFMLVNELMECTDSTAQTEIRATLMYTFAGVVMPRYCLERLKQVVRDLRSRLSEAPPRLPPWIYVVKDSIPGILTILDYWALPINKTTTGILEAHDYVVPGESSAELLSAPGMGSTFKDMVTNKSEGQRAVISSFLNNMPDKELMNAPFLPRNVTAAEARKFVKDHHEKLVDVMMDGFEDQSKKLTGEQKWYKRTKVFFPPSELRKRHAGFDEAFRLAKAGSKQSQAAKKKLTNHIKNDWEVNITLFDNDFTENTAWCPTGYPSLDMDPFGPIEMFHLFNKRLQLDAKATQGENDARTFQTSSTFFGAVAEAIKALTRHITLEFLVGGITEELAKMTLKVDHTRPDSFPRLYTRMWLSNVQDYTHGVMNMTAFIVPSLRCEAESAAATNCLLNTGSWNGDEEFCYTYTLLTFADLPRYLGCKVICKEAVMAVLSLGSQPLPRPLSELASREELTTWLTRVLLYTVVPGKSKPAPYKIRLPHNLAAFVGLLIHLHRVGFPAHWLSEFLKGILSGGIATDLVPYRDFYPIPLADAHRRVSRRRLRLDPWLVELETLLATVQAGLPFPITLPTQATPLPPLEDIVLFEAEAEPPVIARPPWAYTSPFDPVINLLFFRGPASRAASLVSSIPAIFEGRADPAPGSMFVLTSLESVDWRATIRWRMSRVRVERMRREEWYMIAYRVDIYEPSTGPVPISRWTYIGDGNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H662</accession>
    <name>A0A401H662_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1702300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620817.1">
        <property type="nucleotide sequence ID" value="XM_027765016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H662"/>
    <dbReference type="GeneID" id="38786821"/>
    <dbReference type="InParanoid" id="A0A401H662"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="73" mass="7855" checksum="3958503A9ED94918" modified="2019-05-08" version="1">MAPNRLIEDLSARHNLPAMASDAEPPDTLDITMGELDEEDNLLASPLCFSDTHRAPPHYPVPGSSICAIQLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6C7</accession>
    <name>A0A401H6C7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620885.1">
        <property type="nucleotide sequence ID" value="XM_027765084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6C7"/>
    <dbReference type="STRING" id="139825.A0A401H6C7"/>
    <dbReference type="GeneID" id="38786889"/>
    <dbReference type="InParanoid" id="A0A401H6C7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="115" mass="12424" checksum="2E8B213C00EA13F6" modified="2019-05-08" version="1">MVSQADVDKLQGELADLHHSMELQAARSDSMEKELRSSAAEAIAQASKLEMELALAKEDSMAVATSALDEAKKVGKEVATAREETSLVAKSLDAFREKVDSAMVFTAFRPDSHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6W3</accession>
    <name>A0A401H6W3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1801450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621034.1">
        <property type="nucleotide sequence ID" value="XM_027765233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6W3"/>
    <dbReference type="GeneID" id="38787038"/>
    <dbReference type="InParanoid" id="A0A401H6W3"/>
    <dbReference type="OrthoDB" id="4202165at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="278" mass="31146" checksum="D080F989F4F9F331" modified="2019-05-08" version="1">MLQTITLSTPTCPLYLQASKEEKRFDFRDVCSSSGEIPALFNRLPEELVDHALHTLQDAGVELIEWRSLLYRRMGVPVLIKDYHYLVRDEDLHAASDILLHEGLPLSSPPPLLIETGGDFYTQGHMHRLTPSSSVGLAQHLVLYPSSFASYIPSELSPAPSLIPLASPLCKSILVPRQSAVYASILRMMQRYPRWSSTRSTLETHLSELIGYNLYDLQDGYVDVDDEESCQALEVDRRVEDAVEIVRGWNHTGVWRVGEEWMGDALAAVVKGPGDIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H7C8</accession>
    <name>A0A401H7C8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1900890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621153.1">
        <property type="nucleotide sequence ID" value="XM_027765352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H7C8"/>
    <dbReference type="STRING" id="139825.A0A401H7C8"/>
    <dbReference type="GeneID" id="38787157"/>
    <dbReference type="InParanoid" id="A0A401H7C8"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUN" evidence="1">
        <location>
            <begin position="172"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="386" mass="42342" checksum="EF2B2C4E6BB14421" modified="2019-05-08" version="1">MLAFAHHPRYNPSRFVAEEPSEVFPPLKGQPMTADSSFLNESSGDLARAHETDFHSQSRGGASDFSLVPLSDVSLKVATAPGSHAGGAPRRINHTIPTNRDFGPTKWRGLSWASLGNYTWILLGLSVAYFLGIMQPVYVVEISASKIVCQTLSHLRSSTGLLPIPERCRSIDQHLSFGCSCTPLQPESPSIGGRDFALRADGAKFIPGLTTNNFLEKSSEADIQRRIPDLAPTGENHRSFPGGEGQLGIVLVEPILIAQVTINRTQFSPAPSLECLPRDFILWGLIDGDDNVLKSRQNSTLVHRLFSRLPPTFSFPSSSVTESFSPLVYSRYDPRNGLAQSFSIFDEVVLLELDFGVVVLQILNNWGGSSTCLHRVEVRGRLRTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4U2</accession>
    <name>A0A401G4U2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0100160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608057.1">
        <property type="nucleotide sequence ID" value="XM_027752256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4U2"/>
    <dbReference type="GeneID" id="38774061"/>
    <dbReference type="InParanoid" id="A0A401G4U2"/>
    <dbReference type="OrthoDB" id="3222238at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61961" checksum="690DA57596FC71F9" modified="2019-05-08" version="1">MQAPAPLRNKAILRQIFHYDKVNNRTLARLARTCKAFSEPALDELWWFLDDFTHLLTLLRLQCCKVPDKARKKYVLQEEPSAERWARFHSYARRVRRAFMPMAYMDIHPSVYTALAERSHKQPLFPSLRDLLWPYDTFPDYELVELVICIAAQSIKSLRWVRAVDCGPYDDQEPVREDDREPFQLEALCRMLANEAPSLQTLELGSRFSLVLLRFLAPCKRLTKLQISFCTVFDLLQFCAPMECLAELDACLVETFGADIPLCAGFPALEKLTLGDGCAAQVARLLRAISSPDVRYVKMDSLVADSWMDVGACLDALDARVASSLRVFHLGCDLRSPDKPTTRLTVILQPLFRFYQLEDISIRLSVHSDLNSKIRLSDRDISELASAWPKVTSIRLDYPPAAMMSVFTALATFAQHCPSLSELRLGIALDDSPSALVPPTRVASACRPHGLTKLQLAWGELDIRDPVRLARFLFGTFPALDLPWMCANGQVDPALVRALRSRQVRERRRAERREAREAKRLGLKPLRAAPPPGARCGCPRRLVVDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5A2</accession>
    <name>A0A401G5A2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0102140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608254.1">
        <property type="nucleotide sequence ID" value="XM_027752453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5A2"/>
    <dbReference type="GeneID" id="38774258"/>
    <dbReference type="InParanoid" id="A0A401G5A2"/>
    <dbReference type="OrthoDB" id="2794869at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28723" checksum="129FEFD43EB82EA1" modified="2019-05-08" version="1">MASRSVPHISSHQAHSRLSRLTISGYRGASGIGTVHQFVQCLCALLHLRHLKLVDVAFRNGDEPAGFGVLQKGLNTLELEDVSAETLRGLFSLFLSTVEHITFTGCMIPDEMDRLPPCGLQIAHLSAEQDLAPVLRRWSGEDLTVIDCPSFNTALLAELAQPDAVGNWMCPRLMNITVSGCAQFTSGDLRRMVDPRCAVRERTGFPDPGDDEFIVSSIDMLKTSDCGALEPEDREWFDKNICTVEWNSWSGGTKQSVLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5D5</accession>
    <name>A0A401G5D5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0102420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608282.1">
        <property type="nucleotide sequence ID" value="XM_027752481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5D5"/>
    <dbReference type="GeneID" id="38774286"/>
    <dbReference type="InParanoid" id="A0A401G5D5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="85" mass="9815" checksum="A6934039C6D9800A" modified="2019-05-08" version="1">MPLVWSVGEIQWQMRRICSPGRKSKTDPDSTCCPPFRRTLQPHVLAARYVVRIRIFAQKAGVETLWFLGELAYLLDTHSWDLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5I8</accession>
    <name>A0A401G5I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0103100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608348.1">
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019450259" evidence="2">
        <location>
            <begin position="17"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="681"/>
        </location>
    </feature>
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        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="681" mass="71623" checksum="1C75B2F56301F6EF" modified="2019-05-08" version="1">MRSIIYALSLASAAAAQMVVNGVSMVPASAVWASAYASPSNTGSSAVSAPPSQITTPPSASTMPYSSFTAGGYKSLACGYGYSKASDGSCQSESWWQTQGCYETIIINNEGGYGSYGYGSSCGDGYTVTATATATVTQTKTETATIPTTVTVYQTVTQVKTDVESVTTTDFVTSTKLVPTTRVYISTDVVNQTKTVEQTLTAIETSTQVNVYTKTDFQTQTATATKTEQETLTDVITATEISTLVVPTTRTQLSVSTQVIDNTKTVELTQTATLTDNITVVQTATRTEVLTDMVTITKVSTLIEPTTFTSVFVSTKVIDETSTVENTIVSTVVENRTSVQTQTVVSTATATATETATKTDTATATQTDVITDRVTVTQVSTIVKPTTFTSVWVSTEIVDETSTVENTIVSTVVENRTSVQTQTVVSTATATATKTATATQTDVLTEMVTVTRVSTLVEPTTFISVFVSTQVVDETSTVENTVTATVVQNKTSVLTQTAVSTAFATATKVETLTATATKTDFITDMVTVTHLSTVVQPTTFMSVFVSTETVDDTSTLLKTLVSTVVKNMTSVQTRTFVSTATVTDVVTQTATQTANDGALATCLSKCKSFWSLTSGNSNSYNTYLSAPTASQQPSRAATSWHSVPTSSWYSLPTASSPHTWGSGSKASAIASSSSKSSGGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5T2</accession>
    <name>A0A401G5T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0103970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608435.1">
        <property type="nucleotide sequence ID" value="XM_027752634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5T2"/>
    <dbReference type="STRING" id="139825.A0A401G5T2"/>
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    <dbReference type="OrthoDB" id="3229208at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="246"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="523" mass="55383" checksum="121F79A5F75654DF" modified="2019-05-08" version="1">MHFPVYATCITVKLLGKTSPFPEYVLMQMSHSTTIPGQCMNDLQVHLTFDYHPPSRRERIATSGRHAGRLAKSQDMSQFRVSPWITYDPSPDARNEPLVRSNIHFSSMNEDVDMDAPQISTLREEETPEPQPSPSRTSKFRVKLLVNEGKRCSLPSTSTRKQAQAGSEDDEEDEDEEDQLIDDDEDDTQAAPLAPPAQPVASTRGLPAKRGLGRGRGGGRKRGGRAEGASKLVAQPSFGDTLDMTLAGSSTAPGVAAAKKKAAPAKGAMAQRAIRKRPSKLAKAPVAPPQRDDAESIGEAQYPGTAASSPMPYDEHTPEIDISAVPIISAPPFEDSSLEGVPLPMYPLPSKPFPVQPPQKIGTGFAPVIPLDRSRKSVRGWRQVNREVRGIAGGRWFSRTWVGEKESEFASATSAAVAASAAAAAEREAALGLLAGAGGVALPKLPAIAIAGTTGKHSGRGRAAKLDAASSTASASRAGSANPDGIPQAAAAHHIPKKRKSTSLATLNAEAIVPHVPESETVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5U9</accession>
    <name>A0A401G5U9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0104040</name>
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    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608442.1">
        <property type="nucleotide sequence ID" value="XM_027752641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5U9"/>
    <dbReference type="GeneID" id="38774446"/>
    <dbReference type="InParanoid" id="A0A401G5U9"/>
    <dbReference type="OrthoDB" id="5420143at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019515579" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="197" mass="19395" checksum="D094131A9DB10549" modified="2019-05-08" version="1">MFVKISALAALLPLVSALTIQTPANWDSAIQANITWTSASTDPSTWSFELVNPVNFHNSFGLANNVDPSTGVLLVELPVVPPGDGYLLQAVNISNINDVFAQSGDFAIGATPSTSAASSSSTAASSSSSGSASASTTGSSSGSSASSTGSSSSSQTSSSNAPSPSSFNGNGAAHIDTSIGSWIVMAVGAVAGAFVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5Z0</accession>
    <name>A0A401G5Z0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0104600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608493.1">
        <property type="nucleotide sequence ID" value="XM_027752692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5Z0"/>
    <dbReference type="FunCoup" id="A0A401G5Z0">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5Z0"/>
    <dbReference type="GeneID" id="38774497"/>
    <dbReference type="InParanoid" id="A0A401G5Z0"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="733"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="786"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="847"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="945"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="161"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="578"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="847"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117490" checksum="594B96E9659EB044" modified="2019-05-08" version="1">MARSQKQGKMNKLRTSSRKAMNASGYAKRQQSLKSKTPSGGRRDISDVYDYQPEKVRRSKVGLQVGRDEWAGFTGGDGTEDEEETGGPSGGRRPRLVGENDNDSGIGSEDDEEIDSDEAFEESDEERFAGFDFSHKNKGKSKSKPKKKQPAERAVRFAEVDLNEDTDQDEEEEGLEDGDGSVSEDGEEEEEGYPDEFIDVLDILDGRGEPESGNNMGEKEKEGAESRKNKKTEKPILNVQGVDEGNDDEDEEMDAGDGEGESQFQASEEEDDDHRISASEGEDEDLSALQNLEDFVSSLDVGQKRKAPDDAEGTEGRGDDTIRARKRRILKERTEAGEENEFAAHLGGEKLKLDDLLAPLIAQSSNLLSLRKSAKILTSQSGSNKTLSAPLPQRTAERLDREAAYEQTKEEVDKWKATMQRIRDAEHLSFPLQAHPAGKTSNLELAAKFKPTTELESAVDKLLKSAKMREEDIAQTEALKMNHLSVEEVAARRAELAKMRDLMFRAEAKAKRVAKIKSKTYRRIKKKERIRLAAKLGELNQEDPESDETRFKRELDRARERATLRHKNTGKWAKAMKTRGELDEDQRREISEMLDRGEKLRRKIRGERDSGDESTEGGESEDEDEEATIQRIKASAFEELNRLDAQEDADVKSGKKGKSLFDMKFMKDATARNQKRVDEDVDDFIREMGGAVLDEDAEGAELVDQEQSHGATVERVGGRVTYRPGVGSISLRPVGSIPSDTSSVTLKSSDFLDPHSDSPPLDSPVARHSYPPSAIAEINPWLVPQTNVSGPMQKKHEVAVSKNSAAAEKSRNKLRKSAKKQEEEKELAKDDATVEISMTEVITLASSSKALGSSSPESHSNTISAAKPSTISGAEDEDSEVNSELEEQERNLDRKGKGKGKVKANRIQAFAQRDLVALAFAGDRVVQDFAEQKRREIQEDAPHEVDTTLPGWGSWGGVGTKKAPPKPHLIKKVPGVDPSSRADHNKAHVIISQKRDKKAAKYLVKDLPYPYTSKAQFERSVETPLGTEWNTRVAFQRATLPRVVKKPGMIISPLEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6E1</accession>
    <name>A0A401G6E1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0106180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608649.1">
        <property type="nucleotide sequence ID" value="XM_027752848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6E1"/>
    <dbReference type="FunCoup" id="A0A401G6E1">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6E1"/>
    <dbReference type="GeneID" id="38774653"/>
    <dbReference type="InParanoid" id="A0A401G6E1"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000097">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="51"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="504"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="824"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE77736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1009" mass="109006" checksum="7E07287817D9B9B8" modified="2019-05-08" version="1">MAAFRCISRACLGSARPTLCTRSALAATRLARGLATAKPPSSFAALDTFVDRHIGPDDHDVSYMLSQLGYESIDAFIADTVPPKIRISSATVSNESIPSLSESELYRTARGLAHANKPFRSYIGMGYHNAVVPPVILRNILESPAWYTPYTPYQPEIAQGRLESLVNYQTMVMSLTTMEIANASLLDEATAAAEAMVMAYASSGHKKHTFFADKGVSPQTLAVLQTRANGFGLRLVVGDVFSITKDENLISDLCGVLVQYPDVNGSIKDYGDLVRVMHGSGALVVAATDLLALTVLKPPGEWGADIVLGNSARFGVPAGYGGPHGAFFACTDKLKRKMPGRLIGRSRDVYGKPAYRLALQTREQHIRREKATSNICTSQALLANMAAMYAVYHGPTGLQRIASKVHALTQVLKSSVEAYGYKAINTDFFDTLTFDVSGAAKDADAVHSAALASSINFRKVDDKLVGVTLDESVRPEDIVDITNVFAAAASAKPISLSVIAPVQSSAVPQPLQRTSEYLPHQVFNSHHSETEMLRYIYHLQSKDLGLEHAMIPLGSCTMKLNSTSSMIPLTWPEFGNVHPFVPADQVKGYEQLIKEFESDLCKVTGFHACSLQPNSGAAGEYAGLSVIRAYHQSRGESHRDICLIPVSAHGTNPASAVMAGLKVVPVKTLTDGNLDLEDLKAKAEKYKDNLAAFMITYPSTFGVFEHGVQDACKIIHDNGGQVYLDGANLNAQIGLTNPATCGGDICHMNLHKTFAIPHGGGGPGVGPICAAEHLAPFLPGHPVIATGGDNAINAVAAAPYGSASILLISWAYIKMLGGDGLAQASKIALLNANYMAHRLSAHYNLRFKNGNGRVAHELLLDLAEFDKAAGIKVNDFAKRLQDYGFHPPTCSWPISTCMLIEPTESETLQEIDRFCDAMIQIRQEVEDIITNKQPKDNNVLKNAPHPVSIIALSEEEWNRPYSRHQAAYPVPGLLERKFWPTVSRIDDAYGDLHLICDCPSVEELAAPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7B0</accession>
    <name>A0A401G7B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0109380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608969.1">
        <property type="nucleotide sequence ID" value="XM_027753168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7B0"/>
    <dbReference type="GeneID" id="38774973"/>
    <dbReference type="InParanoid" id="A0A401G7B0"/>
    <dbReference type="OrthoDB" id="2756261at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019420317" evidence="2">
        <location>
            <begin position="28"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="19564" checksum="95795691F126AD77" modified="2019-05-08" version="1">MARKLALSTMEISLALWARMAFLRSAAISFDCMPKKVLHLKKQTAMQSPGDSEPAVPATNANIDSCNGSEEPRAADSGHDADAGLSSGTSEVPGPSSQPGPIEEPLYLASGFWNYVDDLLVAICNDVGAHGGTREEQEDALKSFFTATFQNDLRAFRGLGASEKGEVVTVDWQVTIQDNLMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7T9</accession>
    <name>A0A401G7T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMR1-interacting protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0111070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609137.1">
        <property type="nucleotide sequence ID" value="XM_027753336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7T9"/>
    <dbReference type="STRING" id="139825.A0A401G7T9"/>
    <dbReference type="GeneID" id="38775141"/>
    <dbReference type="InParanoid" id="A0A401G7T9"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMR1-interacting protein 1 conserved" evidence="2">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="478" mass="52659" checksum="A27FE2E7A13C4134" modified="2019-05-08" version="1">MQPRQTRPAPQTYSPYAQQPPSYLPAHSQGMLAAYAVTTALSQPHVQNFPQYQYPQASHYAQAYVQHYPNVAAFHPATTAEGYTLSSTYVPGQHTSQQGTMPAMQSRTTAQRPQDRGQTQPHWYQPGNARCTYHGCMFQGSQKAVEIHMMDRHLIYPPGWENRKRKPDWDADPSLKGKPIPIQGTTVKLDTPEAIAGWIAERRKRFPTASRVEERQRKLEDAIARGQLSPEDVRFPHRKKRRLNDGADAHSHNGWSDRGRGWGRGRGWGTGREGGRGRGRGRGANQNWQARTDGNLIPTSGESSQQATGSTHKAAIVPPALGSLIQASSSDSDEDSESESDSDGAPEVVSSKVSPKDLEQEAADSRPESPDDVPNTPAAGTVSTAIQAIQPIKKSLPRQPRRPLRNPFASRPSLLRNLLQPEIRMTVSNLSQAIRFLVDNDFLENVELKPGQAAEKMIEVVGEAEAEDTVNKPANAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8W9</accession>
    <name>A0A401G8W9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0115000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609524.1">
        <property type="nucleotide sequence ID" value="XM_027753723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8W9"/>
    <dbReference type="STRING" id="139825.A0A401G8W9"/>
    <dbReference type="GeneID" id="38775528"/>
    <dbReference type="InParanoid" id="A0A401G8W9"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="272" mass="29915" checksum="44DA76CBAE7A0188" modified="2019-05-08" version="1">MSTPSARRRGSPRLRKDVSRRPAAVLRHCVPGPAPSRPMHINTAALTTIEPMALEPQNQMQQLRKLIAESHENGWDKAWQENVTPWDTGKPQLALQELIESKALDLPTAGKALVPGCGRGYDAIFIATSLGLDTLAIDISSTAVEAANDLVKSSNLPPTVKVAMELGDFFACGSAGQKFNLVYDYTFFVAILPSQRNEWAKTMSSIVESGGYLITLVFPLDPPSDTGPPFYVRPEHYAEALGAGWDKVYDEVPETELESHVGRERMIVWKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G914</accession>
    <name>A0A401G914_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0115440</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609568.1">
        <property type="nucleotide sequence ID" value="XM_027753767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G914"/>
    <dbReference type="FunCoup" id="A0A401G914">
        <property type="interactions" value="639"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G914"/>
    <dbReference type="GeneID" id="38775572"/>
    <dbReference type="InParanoid" id="A0A401G914"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="561"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="749"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="185"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1229"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1184"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE78655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1253" mass="140066" checksum="327E8F085DBC684C" modified="2019-05-08" version="1">MASPPPTDDGFTHQIAIKVSRALNTVNPNDLLARRVQDIAKTTSLDGFILAAKSFGKFKDTFLAELHSEISTHAQQEATGHVPQPVQGIVVHDSEVLEPEPVRAGGLVRNDARHTFRQPAKLEPPTPRTSVLGLDRLAQEKRAAAAEAAGVNGEGSRKKPRLDNGFEPVFKVPALPVSRMANIRQRGEETPSHPGGLSEIARRRLEDRRRTREREGITAQNERRDDAPRGLGDFQRRLNRDRQFDHRRDRDRRGWDATPRSERSGRDEAPSVRVPNLSWDATPRRASSPSASSSRVRDRRWDALTPRRASPGSDEGQGALGLDAHEWEEEQIRLDRDWYMGAEEGGGLGDDEFNPLSQYEDLGAIRQAEVVNKQIKKISAKQAQYNADNDLWEANRMLTSGVATRRTIDLDFEDESESSVHVIVHDLKPPFLDGRTVFTRQLEPINPVRDPTSDMAQFSRKGSALVKEKREQAERAKAAAKMAALGGTSLGNIMGVQDEEAQAEAEAEQKAKSGEKEDYKGESKFATHLKAAAGQSVFARTRTLKEQREYLPAFACREELMRVIRDNQVIVVVGETGSGKTTQLTQFLYEDGYCTYGLVGCTQPRRVAAMSVAKRVSEEMECKLGSTVGYAIRFEDCTSPETKIKYMTDGVLLRESLNEGDLDRYSCIILDEAHERSLSTDVLMGLLRKILSRRRDLKLIVTSATMNAEKFSSFYGNAPTFTIPGRTFPVEVFHSKSPCEDYVDSAVKQVLQIHLSLPPGDILVFMTGQEDIEVTCQVVQERLAQLDEPAPLSVLPIYSQMPADLQAKIFEPTSDGRRKVIVATNIAETSLTVDGILYVVDAGYSKLKVYNPKVGMDALQITPISQANANQRTGRAGRTGSGFCYRLYTEMAYRNEMFANTIPEIQRTNLANTVLLLKSLGVKNLLEFDFMDPPPQANMLNSMYQLWVLGALDNVGDLTPSGRKMSEFPMEPSMAKMLIVSVEYKCSAEMLTIVSMLSVPSVFYRPKERMEESDAAREKFNVPESDHLTLLNVFTQWKSHGFRDDWCMRHFLHPKLLRKAREVRAQLEDIMKFQKMELISAGTDFDVIRKAITAGYFHQAARVKGIGEFVNIRTGLPTHLHPTSALYGLGYTPTYVVYHELILTSKEYMTQVTAVDAYWLADLGSVFYSVKEKNFDDRGNRRVADREFSKRAELESEMAKQRAESARKAQEEALAVKIASGSNSKIIVPGTPRHTGIGAGARVTQTPRRRVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9L1</accession>
    <name>A0A401G9L1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0200450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609761.1">
        <property type="nucleotide sequence ID" value="XM_027753960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9L1"/>
    <dbReference type="FunCoup" id="A0A401G9L1">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9L1"/>
    <dbReference type="GeneID" id="38775765"/>
    <dbReference type="InParanoid" id="A0A401G9L1"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="194" mass="21697" checksum="68126CF3C18780F7" modified="2019-05-08" version="1">MSDIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVMHFCAGLPIILVGCKKDLRRDPRVIEELRKTNQRPVTPEEGMAVAQKIGARHYLECSAKTGEGVREVFQYATRAALLSRPKGGKKHHCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9W1</accession>
    <name>A0A401G9W1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0201520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609868.1">
        <property type="nucleotide sequence ID" value="XM_027754067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9W1"/>
    <dbReference type="FunCoup" id="A0A401G9W1">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9W1"/>
    <dbReference type="GeneID" id="38775872"/>
    <dbReference type="InParanoid" id="A0A401G9W1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="263" mass="29091" checksum="82100B96DC29A14A" modified="2019-05-08" version="1">MSRTSYDRYLTVFSPEGRLYQVEYAFKAISGSGHTAIAIRGKDTAVVITQKKIPDKLLDADTVTHLFSITPTIGCVMTGLIADARSQIARTRSEAAKFRYQYGYEITPDALARRMANINQVYTQRAGMRPLGITMILIGIDPEFGPQCFRLDPAGYYVGFHATAAGQKQQETMNHLEKKWKKLDSGRGADDAVAAGKTLSRADVIELAIEAISTVHAADFKPGEVEIGIVSEGEEEDPKTKGQWRVMDEAEIERHLLAYAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9X3</accession>
    <name>A0A401G9X3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SCP_0201710</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609887.1">
        <property type="nucleotide sequence ID" value="XM_027754086.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9X3"/>
    <dbReference type="GeneID" id="38775891"/>
    <dbReference type="InParanoid" id="A0A401G9X3"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="18" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="20">
        <location>
            <begin position="408"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="962"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="20">
        <location>
            <begin position="1963"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="2517"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1777"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="3154"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GBE78974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="3197" mass="363388" checksum="D955DA7F0DB93E08" modified="2019-05-08" version="1">MTFGDHLSNFLSRLPVEFVKDIRRDKPKNVEEIYFSAREIECLSNLHHVPAQHQNNTNSFCKKTKGFTHRLFSSSSSSPSAASSSPSAPPMSSSPSTGPVPMDLDAMEQPPPLKTKDRVSHELNLFEGSEPPLFTDCCKEPLELSVLDLSDDAPEPHLLPTYAVQLTPSVNAKPLQLALAIIDTGAAYCYIKPSVVRRANLTMYPMTAHSVRGAGATTTSAWAHFAIEIGGWQKPICAFILDTDTLRFDMVIGQEWLQKYNAQPDWATRSWFLMDPHTCQVVRLHVMTVQQPLPLPCIAGAAASNRWASLVAAPLELYSLAEEPVTESPQETSGHKSPLAKIKSFGARLHACMKAKFPWLFHTKLGAPPAGRCEHVINVTGTRPIRVHGHPLSPPEHEEVRKLVDEGLRDGIIEPSKSPWSVPLILIRKKDGKMWVCVDFRQLNNFTVQNAYPLPRIDDSYQNLRGVHFFTTLDLRSGYWQIPLSAASRPLTAFAMHFGHYQFCVMPLGLCNAPVTFQNFMNDLLRSHLDRCVMVYLDDIIIYSPNLPQHLANVDWVLTCLDHQGLILHEDKCQWVQTELTYLGHIVSIAGVRPNPEKVQAITEWPRPDNVTHLRSFLNLTGYYRRFMKGFAKIAGPMYDLLKGNPRKRAKIKWSAPCEQAFVALKLRLTSAPLLSYPSPWRLFILDVDASGHAIGGILHQSQNDFPKGEGDHSCFAFKESDLQPIAFESCRMTPTEQRYSTQECEMLAIDHCLQKWRSYIEGSPVVVHSDHESLKYFLSQKHLGRHLAHFADNIAHFDVLIQYRPGHNQLAADALSCRDGQADVPDYEASGPLFANPMEPAVDYDRSALFETLKKWREDLLRDASAEPSRRGFLVRDGALFHSVDQGQGEVFLPVPVNLDEALRVIREVHTDLGHLGVRAVAKVLKSHVWLPIVTELVEFVIRRCDACQFTQCEAPPAQPLHPLPRTDAFDHWALDFIGPLVKSKEGNEYILTAMDHSTDFAYATAIPRRSHIAVIALLRRLITTHGKPSTVLTDNGEEFLLYPFQNYLQRLGIQHLHTSSYHSQTNGRLEKFNDTLVQTLARYTAPNRQDKWDQYLSDALLAQHAHVSRSHGTSPFFLVFGHQPRLPHETTYDLLRAPPTDAEIATLQNRHLEHVQNLERFRTEANTCALRRLQDEKDLSTLDFNYINPTALPEQYREHLPSQAEWSTERNAHFIGGRPVFIRPDNHNFDYSPEEFERTLPHNLGGIVLQHIADSGITTSYPGERPDAPWNPPAQNPIPQPTLAPIVPDYIPPMATVTMDEGRHHASQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDPNAMDVDRVNISRLYPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKEVSKEETREEQIAYVRNVFNDMTDEERTQLEALIDSGAAETFMNIRFAEENDFIRWELPKPITVMNADGTPNQMGTITHCTWKMMKIGGRKTLTRFLLTGIGKENILLGMPWLKRLNPMINWETGDFWFGKEAKWPPKLTVEDAPDEEVSIFKEDGLPELITTETSPTSFGHSESIREIMADNTERGELPAVRNDTEPDDLSSESPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKSSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVRTRRVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGELHPCAYISQTLNPAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSHRNGLDDSESDNEDRILLPNALFVRSISPTLFDEIRNHAAKDLIVHEALEAIAHKGPVPMKSSLSDWEVHDGVILYKGKIYVPPSETLRRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLRLYCGNNPETWADRLPDLEFCHNTREHSARKMSPFRIMMGYEPRGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYMNPPPDVVDNEEEYEVEAILNHKTYRGHLRPDFALLLRNCDTQMTEALVLVKAIMHKPDDWLAHTRESISLLQFSMVYGLSSEKRRLEALAALPRINSFVDRLVHAAYPGAHLVEFFPILHHLPNRIAKWKRDTEYWFEEDSNMFESLYCNTEPTGDGTRDNLVNAFLSERDQHNCNPREAAWLAGTLYAAGTETTMSVLSWFILVMIAYPDVQAKAHAELNTVVGCSHSPCFADCSDLLYIRAIVKEALCWQPVALTARMTGMATTTSRKGLFAFQTFGSSQLYFIPFAVVTGKFIFDLARSMNRDPDVYGSDAHEFNPDRHLSEDGGIGRALSNTKQEGHSSYGFGKRFCVGRHVTNDSLFINIALILWAFEICSVDDNKPSCADFINTGLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAF7</accession>
    <name>A0A401GAF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Efflux pump atB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0203380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610054.1">
        <property type="nucleotide sequence ID" value="XM_027754253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAF7"/>
    <dbReference type="STRING" id="139825.A0A401GAF7"/>
    <dbReference type="GeneID" id="38776058"/>
    <dbReference type="InParanoid" id="A0A401GAF7"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="88"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="636" mass="70180" checksum="A962BDC00357E320" modified="2019-05-08" version="1">MSTQASGTSTSVLDAQYSLSRTLQDKSETSTAIVNTEKTPCSVENGQPSGQCTVEDMKTPPSSEDEYLVSLDDEEDPKNRSTARKWVIVLVISSAALCATFASSVAAFTEAGLAEDLHTVHEVTILSISLFVMGLGVGPLLVGPLSEVYGRNIIYRISYLLFFAFTWPIAFAPNIEVFLVFRFITGFCGSAFLSVAGGSVTDLFVNAKVASPMAVYTMSPFIGPVIGPLIGGFINQNVYWRWTYRVLLMWQFVEIILLLLLIPETYEPLLLKSKARRMRKETGNDKYYAPLDRREQSIFNAILFSCYTPFQLILFDRMALALDTWNALILGILYLAFQAFPIIFEDLHGFNYQETGLSFLGIGVGMFAALATQPLWNRFHRNQTIKYNGPPPPETRLVMGQWGGILAPIGLFWLAFTTYKHVFWIAPIIASVPFGAGVYFIFTSTFTYLVVAYRPIAASAMAANSFLRSTFAAVFPLFATAMYHKLGTVGATALLAGLCTIMAPLPDPKQIWGQRLTGEADRAAWTLWIEGPTSPTAHSEVLGHEELKTATALPTHCTPVLLNMSLLARSSAPLRQVARSRLVAPSRSVHSEYKHFPFEYNNRGAFATKLAVYLIGGFSIPFVAAWYQIRKSSGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAP0</accession>
    <name>A0A401GAP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610159.1">
        <property type="nucleotide sequence ID" value="XM_027754358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAP0"/>
    <dbReference type="STRING" id="139825.A0A401GAP0"/>
    <dbReference type="GeneID" id="38776163"/>
    <dbReference type="InParanoid" id="A0A401GAP0"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="186" mass="20560" checksum="BF4A09BB57A216E9" modified="2019-05-08" version="1">MNQYPKDRCIPEELPALVEVLPHISILSPNAEEALSLLSMPATPTRILIEEACHRLLDLGVGREGHGSVIIRSGAMGAYVATRRRGGRWVDAFWTDADREAHIVDVTGAGNSFLGGLAAGLLFTDGDVHEATLYATVSASFTIEQEGLPRLTHTETNDGEAIEEWNRDLPRRRLKELQRRLHKVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBX8</accession>
    <name>A0A401GBX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar protein sorting-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0208330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610546.1">
        <property type="nucleotide sequence ID" value="XM_027754745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBX8"/>
    <dbReference type="FunCoup" id="A0A401GBX8">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBX8"/>
    <dbReference type="GeneID" id="38776550"/>
    <dbReference type="InParanoid" id="A0A401GBX8"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="269"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="388"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="67149" checksum="F10BBF7E4FF3BB35" modified="2019-05-08" version="1">MSSDVYHCIPSNSHPTHGHDHQPSYRGRAQEFVELHDQVQNSVNLLDSLETFLSTFQKDLSAVSGQISNLQDRSKDIENRLKSRRKIEKPLSSLLVDLCISPQLATLILDTNVGEPWISAIGDFENKLEALKARARVKAARDLAEVAEGLRIVAATKLRGFFLALLHPVRTSMTTNMQVIQTSVFLKYRPLFGFLQHYAPSVANEVQRAYVGASRTYFETGFRRYIRSLGWLKTRSVEKVETIVDGVGESLLDSKTDAEVDVERLAYAEIDGPGVVLAYMADDKLHKEPIEAIVRSLLLVLMDNATAEYTFVTSFFVSEERPSVHQKDSSSSVRSPSAVLSPTNAEFDELRSNAGSDLNALSRRRFSSINNAMNVPQMSAKEEQASLAAIWKQIMDPVLEYCQTFIRTVLDPVPPVIPLLTMIRLTEEVIAEVQRRDCSPLESFIFGIRLQMWPVYQKAMAEHIDALKKLAEGVTTGYFRRGVATTDAGVHTICQRYVVLFNSFIVLTEHAEETMIFSNLLRLRQELSKLIITHTDKIRNTVDKASAQGKLYDALLRGLSRGPRPTSHPKAQGEIAYWREREEEARRRIVSTHRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC29</accession>
    <name>A0A401GC29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0208830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610596.1">
        <property type="nucleotide sequence ID" value="XM_027754795.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC29"/>
    <dbReference type="GeneID" id="38776600"/>
    <dbReference type="InParanoid" id="A0A401GC29"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="1337"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1743"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1537"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1911"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2730"/>
            <end position="2849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1911"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1922"/>
            <end position="1932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2757"/>
            <end position="2766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2780"/>
            <end position="2797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2801"/>
            <end position="2813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2839"/>
            <end position="2849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2849" mass="318013" checksum="76131ED1B9E7F327" modified="2019-05-08" version="1">MSVFSLFGALLIGQPEDASTWTIFVLWIVRIVSLSLIFRTYIGPSILSLISNRLRVRSVSLRSIRGIYFRAGTGTLRVDRVGISYHRPCAQSASRFSIKVEGMKLEITQEGPAAPESLPSLSSNIPSISAHLASFQLAPHIWSITRSVLSSLYTLLDPCLRPVIRRAIVTALRLVIRALPALTHILDFELHSAIVTLSTIPGVEFGLEDARFHTQVSLSSLESVVYPDENTDYRSQSRHRRFASVADWNARLTGSLRRTWDRAWGATLVSASISLQVKGVTGTARPLALKELCQEFYMVTQNFVDMPSVNFGLTVRVDPRRGIEPHSVETSLAVKTVDINADILRNLLNIMKADRSTEEEDATRENGLLSAISPPISSRAKWASPASPRSPFMGALSASMRFRWGGKQFAVRRLKTKSPTSQVSLLKSIDFRLSKLTLTHCLRRSPTDVTLTFKATMKHVALSAGLSHPDSNPMHREWLGKKSIPGDELSADVYRLNFFTAALTLDRVGSGALVDHLRVLSAGPLQLDTLVSRWPLPWLHGLNFLLGDPNAQLLVTNVSLGTVQCVERMEVLQALLKRKEPSKPRVDTGPMLPAILCPVPRVAIGFQVDEMCVRLISSSSKGDDVPFALELRSDGFLASAASNYSSITDNHQGHIPHDNLGLRMGLDLVSALKRTFVRVRFGPDMEQGHSDAAHIDYLGESLLSLEAVQLLGHASAIGDIGDESQSVALDVASIYTDLQCSTEALSVELWQPDVIRALSRIAADRGELQSETTPASPRRVLDKLPFGLSASFAIGRLIISVTGPDIAPDERLNISRGVVSQTGVSISYCAVRSRHTEQLRGLHAYNDKRLRLSLPTEQVVKAIAGTATPGKSHSFRALVQVAFWDAMLRDAVSTCFAADDPYCVGDQNADISAREFLRIKHTSIDVVLSGLRPNGFAFAGVKDDCSVTVGVSNVRGSMSLAQVYNLLLAVKTLNLFSAKSASTHSHRPPSLLSIQIRCSVNELQLLWEFPIRTKLFMRLTALHCFIPSEEKIDAKWRSIVFATSVPVDRDGIQKEEWEEVLRLSNWDVLLQPKVRPLAVSVDGDTGRLRIPFDFVLADLILDINVTIKSIKHLSRMISAGRYHRPPVPQAEEAKNVPNISIVVRCLTFEAADEDFEAQLGLIWRTGYDAAIVRKSRDDAFESKVATVLASGSDHVRSSTQDIGSDFQFSSERTVPIAEAHDRLLQVHSVAWRSAILKAKFSQMYKEEGLARRLSVDSQDALKGDLVNVKLPRPVPPLCRLTLDRLSLSMSSPSFASGNLADFLYDLGNGLPRDSQFSLLIPVHLDLSVRSLRFSFRDYPLPLLYIPPSSVEGMVGLHFGSHVVIAEEMGTKESVEWISCEVVKEHNGIHGASPLSILVPKTIMPVKTYANPHIRVTTDGVTDFSWAVSYGPAMQDFLRVLDTLSHAPRDPSPPIGIWDKLRLIFHWRIKVSFDEEVHFHMKGSRDPYMLDGHGAGFALCWRGDTRLLIGQPNKQGELIQVTSDSMLVVIPNIEDTYGSSSPARRNAQDTSAAPSKPQASKSRKYRKVCAKLSSGVRFGVGFVLERACGPECDRCTGTPFHRKCRMFHFLPHYDVKLEQKSVTPECKSNADSYNRFRSDFIHMSLSLTSALHNEQAANLDSSSIHLSPETFALFWAWYSLFDGAMSLPIRQGPRYARKRPVSPKFGQHLATLKYRFSVARFFISHLYVDNSRDAWLDGVTPYVGVKAMIDHFQADMHQRDQERSLNIPGGVQTVHHKVFNAIEVAMRGLELRTVLAIFSEQLKQYVPVDSPPLSSNYRTQTNLTAEDPGSLWLDLDDFDEIDKTPSNFYLLPTGSCPRFTYFKQVKDDDQSTSNESVERSKFGTEQTHVCFLGKEKSVTQVQMTLTSDRIQELQRKYDRQARQGRTNGKSSGNHQEDDASDTRRMIALLDDYVSHLCKVEAASTHLGPNGGQSYYMPSDSVSSEEWATFDHVYQVHCPQVFMDNTIRDILMQYYHCSRSRRGIDYHMATRAVKFIRDQAKAALIDILQEPESPRGAVSTAYAAAVAVRKLLIGEDGQDTAVDVPTRPNTDDPARLDPLDGWSEGVSLRKSHFCLLLKPQIVLRECSTDSVCVLAAVHGKLKSFDIMDDVNADDPVSGKVMSRNFASITGLQTFSPSAVNNSGEGCVPLEVLIDLRCENSAFDRLVPQTDASLQYDKFNRLRLRNNVTSVVRGHEQSSRDHLQNQTDLIRVHVPRFTVSANDRHFQAISSIVTNLLLFSDVAFKTRSDRLERMLFSYDFTNLESAADVVENMQMRLRHAMDTRREAGWKLRGTGEAGQVEMLKIQAHILLLAEELNLIFDGMKLAQDKLNDHPEQKSALLLHASSYEISWRMLDRRDQLLAKLAVRDINFYWLNRQDSSVVNDLSVGDLQAFDGAADAEWTEILCKHDEPATHPLVKRKLFLLADWTVLPPVGGITIYEAFELTFHPMRLQIDTRMGRKIMEYVWPARRNRKQLTDTQSLTPSPDTPSPATDISNIIITASSPASPRRSLSDMMPRKAMDGNKLGIAPLRKLGSSRSFTDLRKAESDTLRTPSLHKTRSIEALVTHPSSPISPTKTQTPKSAEDKDRIALLRKEIDDAAEMKTRSSQKTFAWVRVASLYLVLSIRKEDSFLCRDARIRTRDLEYRNQTWSFEELVDQFIPSDRNWRGWIKMAFQQPLVPVLPVAREIISKTKFIPSRSHHHHDDHGRMTTPKLRSLKSAGRESEEKKRSAVSLPPTPIVDPSLSSLTTEPETMPDSPSETTKRRPRVLSVFKRKGRGDSRSSMDSDISTTGTFSGCAPSHRSKDNSKRVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC45</accession>
    <name>A0A401GC45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0209450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610657.1">
        <property type="nucleotide sequence ID" value="XM_027754856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC45"/>
    <dbReference type="FunCoup" id="A0A401GC45">
        <property type="interactions" value="667"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC45"/>
    <dbReference type="GeneID" id="38776661"/>
    <dbReference type="InParanoid" id="A0A401GC45"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="7">
        <location>
            <begin position="121"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="373" mass="43124" checksum="950EC0F008135717" modified="2019-05-08" version="1">MIDRGWRRSGTYCYKPDLKRSCCPQYTIKLDALQFKPSRSQRKLLHRWNRFVLYDEHGGVDHDSSANKTDLRKRKPTKSKGKEQAFSLTSEIHASERRTTTDEKPAHSFEVTLELSSYTDEKFKLYQSYQKEIHHETEEKPSGFKGFLVESPLHSETIPYSAPCPEHLPRAYGSYHQLYRLDGELIAMGVIDIVPSCVSSVYFMYEKKWERFSLGKLSALREASLAKEIHGAGAPEMNSLYMGFYIHSCPKMRYKGDYSPSYLADPEDYTWFPLEQTRVLLDKYRYASFAHPEHCLEGPPNPQIQPSVPELPRRDLRHIQLMDRVDDGAAVTIPIMASPEWRRPAARQTILSLVYGLGLELAKEILLYLAYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC84</accession>
    <name>A0A401GC84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0209560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610668.1">
        <property type="nucleotide sequence ID" value="XM_027754867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC84"/>
    <dbReference type="GeneID" id="38776672"/>
    <dbReference type="InParanoid" id="A0A401GC84"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="66698" checksum="DA5EACADDA27295C" modified="2019-05-08" version="1">MPVVVPALRVCYVFLNVFETFKTLRLPPPSTRNGGQPSARAVSQRKRAMKGCMAVWIVWCCFSLYERLLDGVVRVFIPFYDEIKSLVLLFFLLTRARGAEPIYLHCLRPLIKPHVATLDAFLEFGTSLGDLMLLLSAIPVDFLRDVYRRWYPSPPAYSRGEYKNSTRSSASSVKQAVGGPERPANDYDVGKRPYPPDGGSRSAPEPSSYQIWYPPPASYDAPPPSSYGAPVINPLSGLPTPPTENPPTYAIAVSSGTASTDEWRQYPPFPSAYPPTPLPTSSKLASVIVAPVPVRPSSGVPFSDIPEELMEREDPAVFPNVSAHTAPLNQQDFQRSLQLPRELSNPNSDGGLSDDDDMHGIQSDHDVAMSADEAMDDIVEEEEDDFDVTLRTPYSLRQRIVPPPIILLPSISIDSQASKSTRLSTTDDGSSLRTRTNSDASVARSDTSSVTGRKRRLLHPEDGDVKRRTRSMGKPQPSKLPLHVKPRAAPRVPEIAQDSSASTDTEDTGTTDSDISNSASVQHKRRKVALPPELPRAVSKPIATTRTRTKVSSTTRTSKAGTVPTRPRSTRSLAHLAGSRENATSLPLRNVAAGKPGGSRTSNMAVGKKSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCE2</accession>
    <name>A0A401GCE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0210310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610743.1">
        <property type="nucleotide sequence ID" value="XM_027754942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCE2"/>
    <dbReference type="STRING" id="139825.A0A401GCE2"/>
    <dbReference type="GeneID" id="38776747"/>
    <dbReference type="InParanoid" id="A0A401GCE2"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="32634" checksum="13D87F56F5409708" modified="2019-05-08" version="1">MPPIRTQWTRLIRFVAAETSQVHIGEPVDPRLDVGLASHQKQVIKAYEIHGSALDPNAHVTRKVLTVKELLAPLDRSEIGLVRCLGLNYADHAAEANLAKPAFPVLFYKPVTALIGPNAPVTIPKVVQPPAKHLPDYEVELVIVIGKPAKDVSEADALDYVLAYTGANDVSFRYHQMAVSQWGFSKGFDNTNPLGPCLVTASAIPDPQRVPLRCTVNGQVLQEGITADQIFTVRQTIAFLSQGTTLLPGSVILTGTPKGVGFVRKPPIFLEGGDDMSVWLGAGIGTLVNRVVEEDAKEKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCP5</accession>
    <name>A0A401GCP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0211290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610840.1">
        <property type="nucleotide sequence ID" value="XM_027755039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCP5"/>
    <dbReference type="FunCoup" id="A0A401GCP5">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCP5"/>
    <dbReference type="GeneID" id="38776844"/>
    <dbReference type="InParanoid" id="A0A401GCP5"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="81"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="664" mass="72224" checksum="1B11B078BBE3B16E" modified="2019-05-08" version="1">MSTYDPLSSGFGTDEVEPPWPTTPHSPNSPIPNLPRPSHSHHAPTGLYGKEPQIYGQPEPGLISPRITTASNGTRYEKAEPYLRVRITGLDRNRRDILVKLDAQTNLSNFTGTTYRNVSRSYLEFQQFYDAVVNNNPQTIVPALPLPRTSAPTDEEDDRLVKIMLQRWLSRICEDLILLNDEELRSFIESDFGYQPTPTRRKASSGFSLIRSRVPDEDEELQRARFELTKLEGQYLEAAKAIDKMAKVRKSLASVRAEMGNKLVNVATTEAHPPLGHALQKLGRAWHSVADLDQAQGISECVIVGDSLGYQGLNARSAKETLQQRTAVLEEYQAAVKSTISKRRNMERLKASSNINPLKVDEALEDMEEANKYEQILARRADGISQNLHRALDRHNRLVTEDVTAALVEHVRSSIMYERQLLRELEALKPDVSNSSKKAPPAKTAAPRPTVIPPLEDFSKQPIPRPASGPPSNTLRGPPITAPAPISAVNGSSQPSPFPSSPLPSASSTFRNTLPPQSPGAGPSSPAPSQNSFMSNPLDGPPLGGRLVDGTKSMFIKSTVSPLSPSFLIPPPRSPAPSTKVAPDSPLHAPVATAPHPLVNSPLGPLGESPAARLANGRSATPADDGLDPLGMGRAPLMTGSLRVQPTRPRLDAREAASKLANMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDT7</accession>
    <name>A0A401GDT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0300160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611214.1">
        <property type="nucleotide sequence ID" value="XM_027755413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDT7"/>
    <dbReference type="STRING" id="139825.A0A401GDT7"/>
    <dbReference type="GeneID" id="38777218"/>
    <dbReference type="InParanoid" id="A0A401GDT7"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="93" mass="10497" checksum="0AF17607F4920CBB" modified="2019-05-08" version="1">MPLLGLGGRELELHDRLYCSLKHGYRLGHLNSARFYANEAEVGNAVRESGFLREEIFITIKVMSDEHGYANMLKAVDNSLKWFSSGAHPILYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEE5</accession>
    <name>A0A401GEE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611465.1">
        <property type="nucleotide sequence ID" value="XM_027755664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEE5"/>
    <dbReference type="GeneID" id="38777469"/>
    <dbReference type="InParanoid" id="A0A401GEE5"/>
    <dbReference type="OrthoDB" id="10679171at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="339" mass="37330" checksum="D5BFBF8DF5BCB0BF" modified="2019-05-08" version="1">MFTPVSDDALNAIHTACERATELQGKKPWSPLKFTPRGLLERGDKYRDSSLRMLTTTRKLVDSDIHGQYHVEYDTLSKDREKLTSHNTFRALQNRVQFKKYKDGEKILNRGLVTSSQKSCGEYIWQEKNQQLRANSPVSEEHELSNPSSSNTEDPEQRSPVDGAASDQGPTGAEGTQATPHVKHNLAQTIRDLAHMLNPFGDDHAVDESHHRDGANSAIHETSPDNDGEGETSRDDRGQDEISRGGGDKGETIRDNNGVGETSRQADIEGETSSDNNAEYDATVSLCSFTSDNSAGPSGTTQAILSLDDYSRTSCDGQGFQGFQGFQGRQKDFFLDSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEQ2</accession>
    <name>A0A401GEQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0303770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611571.1">
        <property type="nucleotide sequence ID" value="XM_027755770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEQ2"/>
    <dbReference type="STRING" id="139825.A0A401GEQ2"/>
    <dbReference type="GeneID" id="38777575"/>
    <dbReference type="InParanoid" id="A0A401GEQ2"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="395" mass="44617" checksum="CF83C46C36285316" modified="2019-05-08" version="1">MHIKRVTLTSKKNWWMVELDEEEKEKNSAPANIYSSEETAVNLDAHPHRTVHNRPSRPFDQSPHPTASVIPVYTPSHNPTAIFSFPTPTSYSAHPNPTQNLAPCAAGSASELFKCIVKKPNVVQLEINGEMQTNAKDVTTQFLAELRVYTTLTRHRNIAAFLGCLENVGMVLEYIEGRTLFDVVRESPVLTRNKKIDFHNQLLDGLTHLHSFGLSHGDLSLLNVQVTHSSDTIKLLDFGRSVAADSVYASPSDDTVEPPPFSPTLVPRANSRFVPKPPYIQHPPLPIAPPPPPRKVEQIHPGTRPFSAPEILRAECQDARLADAYSFGMILICLDRCDLVDVKPWDQRKDLLPQGFLDGLEVFRERCEDYLRRWDKGRRRLVREDMMDVDAHMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFE3</accession>
    <name>A0A401GFE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611792.1">
        <property type="nucleotide sequence ID" value="XM_027755991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFE3"/>
    <dbReference type="GeneID" id="38777796"/>
    <dbReference type="InParanoid" id="A0A401GFE3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="973" mass="107466" checksum="CBF7D77D77E85397" modified="2019-05-08" version="1">MPARFVILTEHQPILSEKLRSYDMADAKGRKTLVQSLRQKLKTQFVDTSNYDDIIVETKIREWLNNHARHAQEKATKKRMHVSGKPNAFKVWDALERDKVTEAARALAADKGCNVSKVWRVARSAEWAKLSEEEQKVYEEKAESWRNGTLDDKTKMKLREQRIMQYLKKFAKTMWDTMGIRMAFMLAYPKEAGSLKVEMVEVNHAITNGTPFGAYPGWLRAYQPLAKVFSEWAKGEYCVTETTVTVKKTPADCMRAMDKIQLMANSFPLLPSVPEGMAEAPLKVMKVQVRDFMNHHYALAKGVRNCKSPWTKLNSIDDINEVIPAEMLPENFQWIDPSKMTSVPIRALLDHWRARQEEHGPEQTMRFTQYFNKDGEAAPAKYDPLPPLDGSAQALEEGSEHEVQEALTPKKAGKVKKKGKPVRKVTGKAASKATKGKAAPGGAKGGGRKRKTKDAYDSEDDARSSQDSDRSSLDIPSMASEEDTASDEDSGDGESVIANKAKGKAVATTNGRKANNGGAPQASGSGGAKTKAKRGLQDLPLGELHRFDTEETDEAWSELEPSTKELRLELQGRAPRLTGGSTVGSTVPHLVKRRDVFLATLSVEPRYQDMLKEVKIATVPQVYRFARYDPIPWSEWSYGQRYLPPSFHAVDNFDIVENWLGDKPWLTKYRFLHPQGVQQSALMIGMALRDLTRSQFIEEGEPTNLPDYVVNSAISFDAVEQLLRCCEIITLDMVEGNVTHAMVKPVSKPAIRSAPQGGDGLGGQEEQEGDASARTHDGAATAAKVHKAHQPAPMADKPIIPSGGDEGPSQETSGGASDDGEEDDAHLSVPSSGAERPPPPPFIPKTRKAAATEDRPSGQAKVLQGRSITDALQSNIPGRITRSQRQAMDESPAKNTRSQHPLGAVKDLKKLPDPKRKRQPARPEPDGEDSSGEDNPPPRKRGHGTRDKLVVASPRKKNARAEDSDDGDKPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFG2</accession>
    <name>A0A401GFG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Orsellinic acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0306480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611839.1">
        <property type="nucleotide sequence ID" value="XM_027756038.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFG2"/>
    <dbReference type="GeneID" id="38777843"/>
    <dbReference type="InParanoid" id="A0A401GFG2"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="394"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1302"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1645"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1747"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1302"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1464"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1723"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="1336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE80926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2098" mass="226154" checksum="28BBE40432CB331A" modified="2019-05-08" version="1">MTQSLPYNAFLFDGQGTPASFAPQTIATALRDAELPLGSALLLACHQAFLHEFQSLSPDEQSVSGLDIPRFSSPRALLHISLDLRSNAIVANTHLFLVQVLRYLAAAGVSSPGSSGFSTEASNFIGFSSGMFAATVVAASQDIPSFLVNAVETFRLAFWLGLRSQQFASSTLSLQPSSDASAPWSFVFFGAPRDEVQRAVDSYNQNQPSGPVLHLTAVTHATCVSVSGRPEALSEFRANHLLSTSSKSAAIHTLYHSSQTGEVKDRIMADIARRNIRFPTYDALKHSLRSTVDGEIISGANHGFSPTLVEAIVDMTMLHPVNFDRVIAAISSDPAVKDRSLRLMNIGPGTSLWRGMARSLQDLDITVVDWTSIADSEGPSNPVPRALVDSAPSREPIAIIGMAVNLPGAPDINGLWEVLEKGLNTVSEIPKRRFDVSKYTTPSKDLKRVMKTRFGNFIESPDAFDNVFFRVSPREARSMDPQQRVLLQVTYHALENAGYVPNATPCFNPDTFATYVGVATNDYVQNLRNDIDVYYSTGTLQSFLSGKVSYAFGFSGPSLVIDTACSSSMVSIYQACRALNNGDCNAAIAGGVNVIASPDMYFGLDRAHFLSSTGQCRPWDSSADGYCRSEGCGMFVLKRLSDALAEQDNILGVIRGIEVNQSANAESITHPHVPTQTQLFKKLLASTGIQPSRISVIEAHGTGTKAGDPTELESLRNVFAVNRTAENQLHITSVKANIGHAEAASGAAGLAKLLLMMRKRTIPAVISLKQLNPRIPELSIDGTCIDTRLTPWSAPADGDKRLALLNNFGAAGSNGALILEEPPVPQSSGTASAPTAVVVGFSCDSEAAAAELRRSYLQYVDESVHDQLSLADFAYTATARRKLYRYRVAASGKTKAELCANLKDAKMIEVEKSAGKTVFVFSGQGGQYVGMGANLYKSTPAFRRIVDECHSKLISWGYPSILSVIRPSGDADSASADSFEVFQSAVFVLEYALASLWMSWGVRPDAVAGHSLGEYAALVTANVITIDDALKLVAERARLMSQKCAPKITGMLAVRVSPSKMTEILKSANYQSLSIACYNSTADCVLGGNLDELKLLQGELKQAGNKTILLNVPYGYHTSAMSPILQDLCQLGNQVKISAPTIPIVSNVYGVVVAPGDHSKFTPDYFSRHCGEPVQFEQGVTSLMGIEEFAKVSAWIEIGPHPTTLPMLRSIPLASQNTLHLPSLRKDILDWETLCGTLSSLYCAQTSLSWRSVFTDLAQTARLVDLPSYPFADTRFWVQYEDERPTQSLDAPVTKAAAPPRFSLLGTCISVPPPDVEEAAVFETPIEILSHLIEGHLVAGFALCPASVYHELALGAAHILLEKTGKLDPDVVLDLSEIVYANPLVYSSEVRRTIRVEVTPYERDEKHTGKFTIGSWVDTPSDNQAHCSGFFVKRSATYASSKLALSKTMIERRIQPMQNGSPASETFFTQTAYNVIFSRVVQYSKAYHTMKSVTIDPNGVDAFAVVKLPPEASSGQFVVHPIFMDTLLHVAGFVINCNAGQNEAFICSQVDKAKAIPELINPSTTYGVYCNIGFLSETLAVADAYAIELDGTAGNVVAHMKRMRFRKLRMPGFKSLLARVARGSSQTHAAPAISQPGNRVPAATQGWEDKLIGLIAETCDVNVADIKLQSRLSDLGIDSLMSIELAGRIQALLPSCDIDANAVASFNRVGDLVLELKDKCGSSTSASSDTLHDSDIVSPPPTQVSSPRTPDSLLKIKEIMSSILGVAMRDLSEDQDLERLGLDSLTSIEARHALQSSLNVNLAEDVFMICKTIRDIDTAVSAMLSPPSDVPKVHPKHTEQSEKPALLGTEINPVRLQEGSSAGTLPLFLIHDGSGMAHPYARLSPLGRPLWGIHNPKLPTGDAWDGGVLEMASHYVELIKAASGTTGCIVGGWSFGGVLAFEVARQLIRSGIRVPGIVLIDSPHPLTKSPLPDSLIENVIGGKGSTNKLTELVRAQMRHATRALISYDLSQSPASGVLPPKAVMLRSQEAFSLPSVETESAAFLAERGDPASSVAQWEKVLGVSVPVIDIPGNHFEPFEPRYVGVVSEKLKEAVAMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFP2</accession>
    <name>A0A401GFP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein hob3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0307370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611927.1">
        <property type="nucleotide sequence ID" value="XM_027756126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFP2"/>
    <dbReference type="FunCoup" id="A0A401GFP2">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFP2"/>
    <dbReference type="GeneID" id="38777931"/>
    <dbReference type="InParanoid" id="A0A401GFP2"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="17"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="264" mass="29867" checksum="E5E79A1B36F269FC" modified="2019-05-08" version="1">MSWSGFKKSMNRAGTSLLQKTGQIERTVDRDFADEETKYKTFEKECQQLLKDSKGYLDAMRAMTSAQSRLAETIDVFYGAADHNSEGAMAAHAYKRAVDDLDTGVGRELDAPYRTTVMEPLGKMNAYFPVVNEHISKRNKKLLDYDSARSKMNKLIAKPSEDPTKLPKAQQEHDDAKEVFDMLNEQLIAELPQLLDLRIPFFDPSFEAMIRMQCKFAEEGYEKLGGVQRYFADNVRDDYAAGQLDAQVEGVLQEMKELTICGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFR3</accession>
    <name>A0A401GFR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uridine nucleosidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0307570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611947.1">
        <property type="nucleotide sequence ID" value="XM_027756146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFR3"/>
    <dbReference type="STRING" id="139825.A0A401GFR3"/>
    <dbReference type="GeneID" id="38777951"/>
    <dbReference type="InParanoid" id="A0A401GFR3"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="438" mass="48147" checksum="3E77A27A8CBDBEE0" modified="2019-05-08" version="1">MSSDGFYTGKIPVIIDTDPGVDDTLAILLALTSPELEVLAIIISFGNTDTQASYANILKIYQAIARHIDCHPEDKSQFPNYSPPTRVILARGSEGPLEGDLHSAQYFHGRDGLTELSQRHPDLNISDVNPTDHPQLELSNTWGPELVLDLIRARPARSITYLALGPLTNLAHAMRLDGDLIRSRIGRVVCMGGALDVPGNTSPVAEFNFFADPYAVQELLTPTMVDSGLPLERFLLLPLDITTPHELPFPYYKDKVDPAFHSTAVPSQAQGKPPLVHFTSSFLERTREIMIEFGKDAMELHDLVAVWCAIENPPVTDETEGGLPAVRSGWKATKRRFKVERLGEISRGMLVVDRRDEQGAYDPGANRAQVQAELEQHQFRHAGTFESTALPAQVELERPPVLPQEGAEQPPGVPCIVKTPGPSVLLTLMLKRIWGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGC4</accession>
    <name>A0A401GGC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0308970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10 11">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 12">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612084.1">
        <property type="nucleotide sequence ID" value="XM_027756283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGC4"/>
    <dbReference type="FunCoup" id="A0A401GGC4">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGC4"/>
    <dbReference type="GeneID" id="38778088"/>
    <dbReference type="InParanoid" id="A0A401GGC4"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 11 12" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="278"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="295"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE81171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="349" mass="36445" checksum="1E9D7D2433AB878E" modified="2019-05-08" version="1">MLRARCVIPHRILLRPYATSPGPHALVFLEHREGALDSGSLSAITAARRLGGEVTGIVIGGPDQVPDVVEKAKKLKGLTKLLHSTSPAYSSQVPEIVSPLFERLLSDGTPFTHVVSAHSSSAKSLLPRVAAKLDVPAISDITSLEHDGSSNATTFTRPIYAGNAIATVRAPSSIGVKIFTVRSTAFSAAPSEDGSQVQVEALDPVELADAPTQHIRTDLTKSDRPDLAVAGRIVSGGRALKNAETFKATLEPLADVLGAAIGASRAAVDAGYADNSLQVGQTGKVVAPELYIALGISGAIQHLAGMKDSKLIVAINKDPDAPIFQVADAGLVADLYEAVPELVEKLKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGX7</accession>
    <name>A0A401GGX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0311590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612343.1">
        <property type="nucleotide sequence ID" value="XM_027756542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGX7"/>
    <dbReference type="GeneID" id="38778347"/>
    <dbReference type="InParanoid" id="A0A401GGX7"/>
    <dbReference type="OrthoDB" id="2955493at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019023407" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="145" mass="15544" checksum="D39BFD71DF6CA3DF" modified="2019-05-08" version="1">MRFSTLSTLLVSTLTFGFTLAAPSPAPASLERRGVATVEEATSKAPNADISYPGYDAILVFSGEGCSGTEDIIDISGLDLNVCYEPAIEYLSIMAYSPNGGTWDLTIYAALADCDDAVQLPNLNVCYNTLYDGDDAYFSTIYFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH09</accession>
    <name>A0A401GH09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0311440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612328.1">
        <property type="nucleotide sequence ID" value="XM_027756527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH09"/>
    <dbReference type="STRING" id="139825.A0A401GH09"/>
    <dbReference type="GeneID" id="38778332"/>
    <dbReference type="InParanoid" id="A0A401GH09"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="690" mass="76821" checksum="62D4965BDB657E73" modified="2019-05-08" version="1">MERVHFQQEQMLAELKDLVQRGLFTQKEAKQILQKRTAFETALVRRVAKKGDFLRYAAYEMGLEALRRKRVERLKQDTAPPSVSDYALVRRQFHIFERALKKFKGDVGLWIQYVRVAKKERARALVGRITARALQLHPNVPALYILAASHELQHLSPSTARALLQRGIRLNADSVEMWREYVRMELGFVESLRRRWGVLGIDVAQGDKGKGKEMEKEKAIDEGLLAFEDEAMGEGEDVQMAADQEEGAEDEAARREIMQGAIVKSVMDNAAKALPKFELFTSLHDLLVIYPCPPELRDALLEHLFVLLRSTLPTDPAAIKLSATRYLTPGLKGEALIDALKGANEQLVKAVRDNSTSSSSLAAAYVTFVKEWCEKDVDDTLKGYLVASLHMLAQRDAASAALMAAEIRLLASYPQIHPFLPPSCNSIPHILRLARKYTRKASGAEEMWIARLELESQFTEGKEAYQATWAEAREAVVEGDGVTTVWLWGLERAREADVEADVELLETLLRESKRITDPAAWSAVHEVLLVRYAAAVLALADGDVARPGPGERSTPDRAQLGAATAAARAGARVQRVRHIATSYLPSAKVWARVFAQEAAAMQSGLQGDADLKVLEEVYEYWRREDGVAATAEWAKLLLRRGKGREAQAAVMRARSWLTADESGEVERRWAIDLEGPPEDSGAAAAACNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI94</accession>
    <name>A0A401GI94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0402520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612791.1">
        <property type="nucleotide sequence ID" value="XM_027756990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI94"/>
    <dbReference type="GeneID" id="38778795"/>
    <dbReference type="InParanoid" id="A0A401GI94"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8111" checksum="52479EC70425A683" modified="2019-05-08" version="1">MDGCSRAFRWYAADAAVRNSKVKVLPRLRRLTLDFPRLESAFEVADLVNLVTTFPGLAELRLCPVVRFRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIE1</accession>
    <name>A0A401GIE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0403020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612841.1">
        <property type="nucleotide sequence ID" value="XM_027757040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIE1"/>
    <dbReference type="FunCoup" id="A0A401GIE1">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIE1"/>
    <dbReference type="GeneID" id="38778845"/>
    <dbReference type="InParanoid" id="A0A401GIE1"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="86" mass="9287" checksum="70F008A658E53BFB" modified="2019-05-08" version="1">MENDQGVLVDLYVPRKCAATNRLITSKDHASVQLSIVDVDADGKALPTSTSFAICGQVRAMGESDDSLNRLATKAGLLRNVFSYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIH1</accession>
    <name>A0A401GIH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0403450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612882.1">
        <property type="nucleotide sequence ID" value="XM_027757081.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIH1"/>
    <dbReference type="GeneID" id="38778886"/>
    <dbReference type="InParanoid" id="A0A401GIH1"/>
    <dbReference type="OrthoDB" id="6270916at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="610"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="998"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2335" mass="262192" checksum="3D0AAB59549E63BE" modified="2019-05-08" version="1">MANPVLRLDTTFLDTSIVDSSTSQSLTTPAARSRARSLSQAVLPSFRISTTPNTDKPSSEASNAFNVSVSHAVNKARNESRKLLAHLLAQLQSRPVPPSVLEVLTNGGCQKSLASNAQSFRGAAKYHGGARDVQVLPRVSHDDTDGEWEDDAQFNTDVTLDLMNQLKDVLLISAAQKWDIFYDSPTDVSRASDRFSEVYLRRRSRQVTKRRSRSRSRSVSMATEAEGAVQAPHLLSQCISVITSLITEDCRFRTSSPRPSRPPNALQSVTLDVAQFLIHEHRHDPKILSQIAFAVIPAFYMFRPSLHTRLLSFFDDGVIGRVLHDLRRIQGRQTNEQMLPSTDMLGGDFLSSVQSPVVAITVDAADDVVISPSESGWRRWQVSGDVDCQSTNVPLQDIAVYQMSSVISPLLAAILENVDIVSESLPTVHRFHRLLTRIAEYKPDAYEDILSIIAYHSPRARYFAIGLLMSYWSRAVGHLAVSRSFPSITYSASLAKALQGPNYTRHLSDHPYAHQFIPWRFNSESMRNLFGGPSHNECRSCSDAITGFGLLCPFCMCAVHFDCYDYPEGSFFTEYFPALEPDALKVAFFRFCHLHPSRRTLLPAPILREEHTFRPVNLFGMALCFICRTPLWGCMTQAMQCQSCKQFVHAHCLEATSLPRCRSVSVDDTYLTIDFSVLRRSFTEFYRDISLALTDPSRRTYEEVSLFYAMLWIQLELLKNGVVLGSILVVPENSEKPVSNDSQLEEFELHQLIKRCEEYLSSGNLSVSRSLTDFFVENNVRAAQAFIFFDWNALTFIASTIKMPHQVPGISTSLSSSDLLSVGQMDVFESEPEDGSPYPFEIASLSHLRNQLGDQFQLYSEAAARFALMYLSHLGFFQLPDGLDDLSRDISHPERQQCVFPLPFGLEVSAEVETLAAAIEACLSDFDLSVNEAGFLLLVRRFCPDGLMTDYALRRLAKAVVHWILSEDNNLAVMLRDYVAEGRSLPGVRSGLDPQPWPSSSESRPTAANSVNNGGDYVASRRALLHRYAARWLLALHNQDVDKYTTTIFDLLEEHANESEPSDLILAADDFQKRRRLAATDNVLRLIMKLHQAGVVFTSYHDLFGRWLELASDVRHDEEPIWSLSRLFTREIESSQRSGSIVENRMTIVDPSTVAPLNPVNVLIDVATGSKEGYLRTLHWLCLLVRAGVDVSVSTFMQLVSLAKRFDVTVNECLLLVKAIMWSTWLRVMGRQDLQNVVAALHAHFAPQVVARLQSRDRSPEMFLFIRQSLATCLLLYGCDRSYVTYLGMIHKEETDGLASRRKLPRASMSADPIIVNADLISALKLYVQTEIHDVSCLVAKFLNAFLNEAAFVESYEVDNFILRNGPMLCTCMWQFYAIQHHDISTIRTSLLLRVLVVDPQPFQALLEEWFQVDISWELRLQAILRLFRIILDVTSPAFSVEDRQWRSTVIDVFYYFFSSLWRDPREEVRLAVDTWSQTLLPAHFDAITACWNESLAKSTISERIKLISFLDQLRPHFPDWRVLSWECILETLLESDFMQRNGDNEDGPAAAHLSMYGLSSSSKSPASYAVDLDPELSHLRVSLLSLSMRMVSDGVFIDLVSLLKIKDHVARVVGFQDVTIVPTASGHTFHVRFSALGTIAESADPCLNDLMMILDSSRSYDLPPSAMGGLYAEDDSPCHLLVGSVFVDILLDLFVHAEAVGTLSPITLKNMLKSLIILVHKHDFDSKPLMHLQGNLRRAVRHTLDLLFMNLSYEIRQLALSACLAFIKRWPTIVGNFICEAIEAAVRLMVVLDYERHSDDVLVEQTRGFLDTTLTLYSQSGVFNVLCKRQLLSEFFDVIHYVVVANTKANISTIREGLQDELLRDTLTKAIENEPDSFQRVIGNIVSYVEVVHHSGYSSDMMQFVGLRLTHIVRRTAEWSADAFDPNPLLRLACTLVQHNKAQSRDLLMYMETLLRAALVRFHVSAESLARIVLATSMIYRKAGSITNSGDALQTNPIVYSMSEILSDGLHGKARISPTTLTALVQTMSAAMDHGVVKVAILSEDAFFRLADDGLFFLYNDGVSDGLSTADFNTSQAVANLVLQAADVRPAILGRLLRIQATIHTWNMLVLAALASESPSSAFRIFDYFSTFSLAYARSLCSYQHPQWPLDIDAQEIAHRDISNAYAALKMWLLLARRAAAQRIELAVNSRRNGADGDGMLDEEILATSMVWNELWPPFESVMSAFEADAHAGNHSPLASTIWASVADLLLFLRQSRSVALDTSLETRILNRLRTIVRGEAKLSRILRSMTEPPPDVAFDFLVRQVTTEIEAEEKLQAAKRQNAIPERGRRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIJ1</accession>
    <name>A0A401GIJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0403050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612844.1">
        <property type="nucleotide sequence ID" value="XM_027757043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIJ1"/>
    <dbReference type="FunCoup" id="A0A401GIJ1">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIJ1"/>
    <dbReference type="GeneID" id="38778848"/>
    <dbReference type="InParanoid" id="A0A401GIJ1"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="2">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="254" mass="29341" checksum="D32AD5D2FC4FA8E1" modified="2019-05-08" version="1">MSFPNLTLFRHYAESVPSAIPKTVLKTHTDNSVTVADAYPKSLFHFIVLPRALPPLDISNLKDLRTLLKCDREQALQVLKRLDADAEAVRAIIEAEMVSKYGFKWEIWTGFHPLPSMEHLHLHVLSADLCTPAMKIKKHYNSFHPKLGFFLHLEEVLSWFEATPSFYDMKRALTPRQYEDRLKEDLMCFKCDDVFKTMPKLKEHLQQEWDRMAKREKAKLAKKRKREEEAAAKAGDGDDGNVKAKKCETESPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIY5</accession>
    <name>A0A401GIY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0404980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613031.1">
        <property type="nucleotide sequence ID" value="XM_027757230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIY5"/>
    <dbReference type="GeneID" id="38779035"/>
    <dbReference type="InParanoid" id="A0A401GIY5"/>
    <dbReference type="OrthoDB" id="3236040at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="270" mass="29567" checksum="676E7454B67EBC3C" modified="2019-05-08" version="1">MPSLRRTLSSPSARTSPYHHHSSHSNGNVTRAGGNTPRRSSGSDTSRRRVLADIDWWRVQDGQRDQSSSEEEQDAPADNQADDLAGPRVENTNAGVSALNDGTVPPAWQPVAGAGIGALGATLNAEPLFMDMMMHVPDLSEALSPIPQFADLSISPRTPSRPRYTHSSQSSESSLASTPEVLYNALFPAPTLERSLTDMFSFNDTYSLDSLSGAFAMPRAVPFGTRSVSYSSVEPQLSSNRRRRQERRFDDIVPPPFFSLTREDVDDLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ07</accession>
    <name>A0A401GJ07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0405180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613051.1">
        <property type="nucleotide sequence ID" value="XM_027757250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ07"/>
    <dbReference type="STRING" id="139825.A0A401GJ07"/>
    <dbReference type="GeneID" id="38779055"/>
    <dbReference type="InParanoid" id="A0A401GJ07"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="2">
        <location>
            <begin position="344"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="717" mass="77775" checksum="189D8DEF7DCFF349" modified="2019-05-08" version="1">MASEGSKQDMNKSRAQALQALLHSMSPEGSSSSGNGKNLTTEQVRKISDKLGEILGDEELGADGGQRRNEKGELVNEEGLPIIDIREPMADASSPIASAISPEHIFDDPDLLPPWALSPAEKARRRAERERILDLLEEEEHPEQERDEAANRERWLAELERRKEAAKAEMDSLKKARDLQKKMGRALLRNVTETREREEKERAEREKEEREEREKRLKVKPKKSVSFAEPPVSEEDEVGKSETRSGWGSVALGRLERKGKSPLMTKAEMDKQPMRMHVVERHPGAMGASQSQALSDNQDSDDESVPGSPVLADSDEGDVINSDHSEDHEDHPSAHSDSEDIEAEPNAEDEPVVWDEEELDYARHQREIALAYYEKRATITSDVASAMRAHTHDEAENDWDQPEVPLDATLASAPPKSSISRFKAEHSSGTSSSSLASHSLGPSVLPSSQSSSLNRAVRMGKLVNGQLTGGEPGDSGDDGEMEAREILELLSRGQVKNVGPEANSTLPQVGNSVFAGPSNTQHRAPVSPALETTADADGASAPPKSKPSKVSKFKLALSQTQWRSPGAVSPTVSPSTPSTIVERSSPKLVSPPLLTPIATPPIPSSPGRMSIPSGAREHNTVLSAVQQGQMPSMIVESPSLPTSQVVIDSPSFQTSSSHQVLSPKGPAANRSPPGTSVISEHPASMMAAEVRESTSTPLPGDELRKERKISRFLAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK00</accession>
    <name>A0A401GK00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0408580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613387.1">
        <property type="nucleotide sequence ID" value="XM_027757586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK00"/>
    <dbReference type="FunCoup" id="A0A401GK00">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK00"/>
    <dbReference type="GeneID" id="38779391"/>
    <dbReference type="InParanoid" id="A0A401GK00"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19491">
        <property type="entry name" value="XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047348">
        <property type="entry name" value="XRCC3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF66">
        <property type="entry name" value="RE19845P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="75"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="492" mass="53588" checksum="B8BCD02E08ABE309" modified="2019-05-08" version="1">MEARSLLTVTSLSGDDRTALKKGNILTVADLMLTSPGDLVKKCRFSLNEAQKIVDLVCRELAHQPRMLEDVVEEGEEKFTTGDLRLDETLGGGIRPGMLWEVVGESAAGKTQLALQLCLMVQLPLELGGLSGSACILTTSAHLPTTRLVEIADTHALLSSTHCGLSDIHTIKTPEIPILLHVLSTTLPTFISQQASRDGAKPVKLLIVDALTELFHSDSKTSKHTLFERSKNLSEISALLYDLTRRHRLAVLVLNEVIDVFGATLEADAGFTGDMLYRDQARFFGRADSVPGEERKEAALGLVWANQVNARIMMSRTGRMRHIDVSNLASSRRKRRRLEDASDGAQRVGDLPMFVRRLSVIFSCVALPASLDYVVCDQGIVTVPEEPAFPEPPRAVSTESVIAPGPTATPAQTPYDVSPYDVGLISGNPKLVDSNAQPAEDAGPAAESIEAEDGPRADEDEWDQYWKDADTDDSLYRHVDTYLAPPINATPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKL7</accession>
    <name>A0A401GKL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613597.1">
        <property type="nucleotide sequence ID" value="XM_027757796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKL7"/>
    <dbReference type="GeneID" id="38779601"/>
    <dbReference type="InParanoid" id="A0A401GKL7"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="395" mass="42792" checksum="D8B706E675149D6E" modified="2019-05-08" version="1">MSMAPPEGVPHRPTMRRKSSAQNLLSSFKTSSNTTQALPSGSLSSATGMQFAPLPTPAVSSARDWDVQSLQSESVGSSGGTSIATNGSASLAQGTSVEMLRELVRKRIITLTYLRNVHEGRSHWFHTIMITRAELDRVFANSVMKNRTYRFAMLGMALANLFDVKEPQDLLRGLSNALNEYDQSKEDSDKPKMRLFRTKPQKRQPGVTDYAISTFADPSESSYMQMPHVPFPFDYHQTLLSLLDVLSEVYNKISKILGPSPFPSSGHHMMGPLGLLSPHPGVSYLFAGADAAPTNDGESSLWGIAHATGPGPGTPGLVGAAMYGGALGSPPPSWNSALGDTVKQIDNRLKKLVAMLLKELDDCARAGIKDELASLDPLLRHVAVPEDAREYDLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKS1</accession>
    <name>A0A401GKS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Multifunctional cytochrome P450 monooxygenase af510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0411560</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613684.1">
        <property type="nucleotide sequence ID" value="XM_027757883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKS1"/>
    <dbReference type="STRING" id="139825.A0A401GKS1"/>
    <dbReference type="GeneID" id="38779688"/>
    <dbReference type="InParanoid" id="A0A401GKS1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE82771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="509" mass="57210" checksum="0033BAD51582FDC2" modified="2019-05-08" version="1">MYHSLASALLILYLVATFFVLIKFALHRRLRRPLPPGPLGLPIIGNVLQIPQNVSMWLTFAYWGRRYGDIVHLSMLGRSTILLSSPTAIHELLKNRSAIYSDRPHTIMACELVGWQEFLPLSPYGERSRQFRKVMSSVMGPRNAEKLHSMQEQNAHRFASRLQESPAKVRSHIRWLIANTAIKVITGFDVETLDDPLVQLADKAVFEFGLATTPGAHLVDMIPILKYMPSWFPGAGFKAQAKAWRETVNHVRDDAYGLVKEHVAQDSAAPSLLTSLLQNNVHPDPQLESIYRHISGTAYTAAVDTTVAGIEWFFLAMTLHPDVQRKAQAEVDGVIETGRLPSFSDRPKLPYVEALIKEVYRWNPVAPLGLPHRLTRDDVYEGYHIPAGSTVIANIWAVFHDPVLYSEPSDFNPDRFFNRKSNFLNPDPRSFAFGFGRRLCPGMHLADDMLFITVVTTLAAFNIEKAVDRDGRPITPVVHCENGVVSAPGPFECRVTPRSAEMMNLREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL18</accession>
    <name>A0A401GL18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0412540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613780.1">
        <property type="nucleotide sequence ID" value="XM_027757979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL18"/>
    <dbReference type="STRING" id="139825.A0A401GL18"/>
    <dbReference type="GeneID" id="38779784"/>
    <dbReference type="InParanoid" id="A0A401GL18"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="382"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE82867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="706" mass="79467" checksum="77954AD05E64D743" modified="2019-05-08" version="1">MDPRDWRDVHLRSPRRKPPHSRRESSGRRDSIDRRPRGDYVVRSREYDSRHSGDYGRDRDRRDNQERERDRDYHSRREDVRRDDQRRDDNRRRTPPAPREHHSAGPSNDRPHAPRDESEKEEGEISPRPSRGPTPVPSQPTRAPSPLPQEKPQPQPEHEMELDLSGSPPSAETTLAARRAKRRAILAKYAGIASTSVSQTASPSPGPTSAVEPPTAFSSVSNPVSHINSIDGTPGVSEAPTEGKISKRESESVSPTPASFSLAKDGDEEDVQAKAQAQNGVHEQISAADYDPSLDRREDEQKRVRVKEEPTSNVEDVEEIEVEEDEIDDMFAAVTSEKNVKKVKKIVRTAAPALITTTLDSAADPEGYYQIILGAQLDGGRYQVYSSLGKGMFANVVRARVIHGEVGDAGKEVAIKIVRCQESMYRAGLKEVQILNKLKQADPEDKKHIVRLERTFEHRGHLCLVFESLSMNLRDVVKRFGKDVGLNIKAVRAYAHQLFLAMSLLRKCNIMHADIKPDNILVNEHKTLLKLCDLGSASDASENEITPYLVSRFYRAPEIILGVPYDPALDIWSIGCTLYELYTGKILFPGRSNNQMLLLMMELKGRFNTKMIKKAKFGEMYFDELGGFGNIEQDRVTGSNVVRKVHITTPTRDLRQRLMPPTSVKLKDDEAKLLSSFVDLLDKCLALDPARRITPKEALLHPFIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL65</accession>
    <name>A0A401GL65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0412930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613819.1">
        <property type="nucleotide sequence ID" value="XM_027758018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL65"/>
    <dbReference type="STRING" id="139825.A0A401GL65"/>
    <dbReference type="GeneID" id="38779823"/>
    <dbReference type="InParanoid" id="A0A401GL65"/>
    <dbReference type="OrthoDB" id="2437251at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="699" mass="80713" checksum="1685E284F81ABB2C" modified="2019-05-08" version="1">MDSTWNTNGSRFELFAILGEAYRSGLPLGYLLVQSSADAEQGAKQDVLEQFLHQLRSQWNLRIIITLSDKDWSEINALRRIFPDAKHQLCFWHALRAIKTRLSILRRMPAHYDIEEAHQEFTFIDVDFLPVSQRQPSSTQYQPRKTALPQLQFRINGVLQPLVPQEHRLMLRLPRRPTIRSEDVVHVEIASGSGTSSEEEDNSESDAAAEQSLQQHHHSNVMEDIGEDIGDGADSGDIRDDVNGKSDEDETDAEDAPDWVFDMGEKKSADPTYVFCPAPHRKALLHLFTKHFCQHPLFIERDGKSHTSEQIRRDAVYEMYLFCQIRGLTEVWAYMWTSWYSHRRWHLWARSTTPWISRARTTMNTENHFKQVKHDFLPHLLRPRLDQLIWILSTKVVPAYMKRAQELEDTYRIGRSKKLTSYQIRFKKAWRTLEKKPISNSGIDYHVNVATWTCGCGNQKYNAYHLCKHLVQAVVKPPPRFFRQVVRRRTIPIYCHPDLRPKMLEGQDVTPEPAEASDGSITDGDDHLWLGNKEKLKGGSWREMTQRSVAESILGKRSREEAMSEGDARDAAEQKHESIETSDLQSGAEDAEDEHSEIDSDEVQGILERGHHTQEVLAELSKIVASQVDYKNIFWLRRFVGDNFAQHAERLLGDIRHVESTGRRRDVTWPRNRSEARRSRNTMGYQSRCASSDAAPSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLD8</accession>
    <name>A0A401GLD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0500310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613901.1">
        <property type="nucleotide sequence ID" value="XM_027758100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLD8"/>
    <dbReference type="STRING" id="139825.A0A401GLD8"/>
    <dbReference type="GeneID" id="38779905"/>
    <dbReference type="InParanoid" id="A0A401GLD8"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006130">
        <property type="entry name" value="PRK08274.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="64"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE82988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="496" mass="53324" checksum="8B50B66C1E49E3EB" modified="2019-05-08" version="1">MSAVEGGSKHVLVVEKSPKDWVGGNGYFTAGAHRTVHGGVKDLLRIVQNVSEEVATTIDIEPYSAEEFIGDIMRLGDNQSDPAIVQAVVEGSSDAVQWLADSIQVPFTLAFNRQAYLVNGRQKFWGGMALSVEDGGKGLIRAHQQALEKAGVEVWFDTPAVELVVDSNSCIAGLIVLHNGERLLLSTPAVILACGGFESSTELRAKNLGQEWTHAKVRGTPYNTGDGIALAQAIGAKVAGDFAGCHSTCWDANAPPDRGDRALSNQFTKSGYPLGIMLNALGRRFVDEGEDFRNYTYAKFGREILRQPGGFVFQVWDSRTVDWLRNEEYGDELVEKIWAQSVSQLAEKLSSKGLQDTREFIYTIESYNSAVRAFQLENASLEWDPAIKDGLSSESSTTSLQPPKSNWALPIEQPPLLAVKVACGITFTFGGLAISPDTAGVISSRTDKPIVGLFCTGELVGGLFFKNYPGGSGLTAGAVFGRKAGHAAAALSLRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLI7</accession>
    <name>A0A401GLI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613964.1">
        <property type="nucleotide sequence ID" value="XM_027758163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLI7"/>
    <dbReference type="GeneID" id="38779968"/>
    <dbReference type="InParanoid" id="A0A401GLI7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="10363" checksum="C5F81DAA78A75DB8" modified="2019-05-08" version="1">MVERELSKLPPHGPPPFHHYHKSATRFLFLIVAEIYFQHLLSIELLNVWSYLLEPALSHLGVLTSHNSQDGSQTMPSPTRPARETVHRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLN9</accession>
    <name>A0A401GLN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0501540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614020.1">
        <property type="nucleotide sequence ID" value="XM_027758219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLN9"/>
    <dbReference type="FunCoup" id="A0A401GLN9">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLN9"/>
    <dbReference type="GeneID" id="38780024"/>
    <dbReference type="InParanoid" id="A0A401GLN9"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="145"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="46865" checksum="9FBB0A0C8AD8FA40" modified="2019-05-08" version="1">MPAKGLFSSLKGIDAFGKTTEDVKVKTRTGALLTLVSAAIILSFTMIEFFDYRRVIVDTSIVVDRSRGERLTVNMNVSFPRVPCYLLSLDVMDVSGDLQTDISHNILKTRLTSAGVPVPNAQSSELRNDIDKMNEQRGADYCGSCYGGTPPENGCCNSCDDVRKAYTDRGWSFNRPDSIEQCVNEGWSDKLKEQASEGCNISGRVRVNKVVGNIHLSPGRSFRASNNDIYDLVPYLRDDGNRHDFSHTIHKLAFEGDEESDVFKAKPGREMRRRMGITENPLDGAIARTSKQAYAFQYFLKVVSTKFYTLDGKSLNTNQYSSTQFERDLSKGRREENNDGVHVSHSTPGVPGAFFNYDVSPILIVHTETRQSFAHFLTSTCAIVGGVLTVAALIDSMLFAASRSLKRHAGSVPSSLAYANGKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLS5</accession>
    <name>A0A401GLS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0501350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614002.1">
        <property type="nucleotide sequence ID" value="XM_027758201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLS5"/>
    <dbReference type="GeneID" id="38780006"/>
    <dbReference type="InParanoid" id="A0A401GLS5"/>
    <dbReference type="OrthoDB" id="2885612at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="263" mass="29496" checksum="2950CC81C87C4506" modified="2019-05-08" version="1">MNIPQDPGTPMQPSATAFVFLDAHTIALAGFLSAAFGTGSLELQSEPTTDDPKGLIDVFTYHLSHIRTFAVYASRTLLAYTGNRLLAAADPLPCDYSSDDEDQKGPPPRLHIFDFSQPLLELLFRLDEEQRDALSTHIVSRNVSAQVRVVSRKYVTVPTAWDEPEIDAEYLWPTACPPEWQGHLVELYERDQARREGESPIPAFEYDEGPVEHRDAVSFGYVQTRLQFTENIDIERIAITSCGVVEVPGPMNDGWVFYFDEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLW1</accession>
    <name>A0A401GLW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0501760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614042.1">
        <property type="nucleotide sequence ID" value="XM_027758241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLW1"/>
    <dbReference type="STRING" id="139825.A0A401GLW1"/>
    <dbReference type="GeneID" id="38780046"/>
    <dbReference type="InParanoid" id="A0A401GLW1"/>
    <dbReference type="OrthoDB" id="2776894at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="14"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="332" mass="36889" checksum="04CD4745F8BDA799" modified="2019-05-08" version="1">MSTPAPALDLHPLNTVALFGATGMLGSVIFKALLDTHIPDYQPTVVAIMRPGKSLDESLKSHPRLRVVTLDYSKGGDELVDALRGVDAVVAVLNGPGVAAQYPILDAAIKAGVRRFYPSEFGFHQAYRAPGDPGARIMPLWDEKERFALHLKLHPAVESGQITFTFIGVGDLYDQIPETFWCPWAQDQDTYEVPVIGDGAALADWSHTRDVARYVVATLSQPACSANATLNFPSEALSQDALVALLRAYSRREVRVRYFSHDEAHRFAAHPAEAPPQIAQSSNIPVDFYFVVKSIQGSGTFRRSRWECHWDLFPEVRRTTFEDYMKERFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMC4</accession>
    <name>A0A401GMC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504390</name>
        <name evidence="3" type="ORF">SCP_0504440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614304.1">
        <property type="nucleotide sequence ID" value="XM_027758503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMC4"/>
    <dbReference type="STRING" id="139825.A0A401GMC4"/>
    <dbReference type="GeneID" id="38780308"/>
    <dbReference type="InParanoid" id="A0A401GMC4"/>
    <dbReference type="OrthoDB" id="3250101at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="194" mass="22087" checksum="97F97136F2E6AB3E" modified="2019-05-08" version="1">MADNTERGELPAVQNDTEPDDPPSEPPMNQLDDDDLVISYIAEEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNMVFYKPFGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPNFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMC8</accession>
    <name>A0A401GMC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614271.1">
        <property type="nucleotide sequence ID" value="XM_027758470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMC8"/>
    <dbReference type="STRING" id="139825.A0A401GMC8"/>
    <dbReference type="GeneID" id="38780275"/>
    <dbReference type="InParanoid" id="A0A401GMC8"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="163" mass="18537" checksum="031C5725CF6449A6" modified="2019-05-08" version="1">MGVNGLWELLKPAREETSLKLLALHDGFEGRPGEWLYRLGIDTSIWFHQLQEQFAAGHANSGENPELRSLFHRLARLLKLPVRPLFVFDGPGRPAHKRSRKVIRMHWMVGNTQKLLDTFGYEWRAPGEAEAELAKLNQLGIVDTVLTDDSDALIFGARTVIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMD7</accession>
    <name>A0A401GMD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0504140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614279.1">
        <property type="nucleotide sequence ID" value="XM_027758478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMD7"/>
    <dbReference type="STRING" id="139825.A0A401GMD7"/>
    <dbReference type="GeneID" id="38780283"/>
    <dbReference type="InParanoid" id="A0A401GMD7"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE83366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13619" checksum="11EA4B572B704986" modified="2019-05-08" version="1">MPALELKTNVALTDPKAFILEFHLFGAKVLNKPPSAMSLSYTYNENLTFNGTFDPAFLLTITSLDNLSPESNEKYSKALFDFFEEKLGVPNDRGYITFFDPKRENMGFKSTHCGVLLPKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GML6</accession>
    <name>A0A401GML6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0505040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614368.1">
        <property type="nucleotide sequence ID" value="XM_027758567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GML6"/>
    <dbReference type="GeneID" id="38780372"/>
    <dbReference type="InParanoid" id="A0A401GML6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="120" mass="13462" checksum="A5C099A25FAA29D6" modified="2019-05-08" version="1">MSNHSATALTASDLNEEDIQVHLENLAEGEVYVERHPSSERVAQVFRSLEDVSQTRSLRALLTPSSFKTRLKFERTELFVRADAMDPDINARQRADTTTPSHLMEVSFATPSSRHCICGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMM6</accession>
    <name>A0A401GMM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Brefeldin A resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0505260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614390.1">
        <property type="nucleotide sequence ID" value="XM_027758589.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GMM6">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMM6"/>
    <dbReference type="GeneID" id="38780394"/>
    <dbReference type="InParanoid" id="A0A401GMM6"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC2_TM"/>
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        <property type="entry name" value="ABC_trans_N"/>
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    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
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    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
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    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="568"/>
            <end position="590"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="642"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="675"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="1199"/>
            <end position="1220"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="1302"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1314"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1341"/>
            <end position="1360"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1464"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="172"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="870"/>
            <end position="1107"/>
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            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="78"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="93"/>
            <end position="102"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE83477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1509" mass="166839" checksum="43D288D72530F202" modified="2019-05-08" version="1">MDPEQLSQLEGHDSVPELPLGTSAAAAHGHAAHNNFTYDEEDPHQKNALTRTVSHASHVEVDMFDPSGMSDLRQTLTHMSTHAQSPRSPHSGRLGEGKRKSDSVSVETEATLTPVDGPFDFEKTLRQIIKKSDKSDIKRRELGVVFQDLRVRGLGASATYQPTLGSVLSPLYLIEKVMELRHPHVRDLLSGFEGVVRPGEMLLVLGRPGAGCSTFLRTLANQRSDFYAVEGDVSYDSFTPAQIHRSHRGDVQYSPEDDVHFPTLTVDETIRFAARTRTPQQRIGQASRDEHIEHIDEVLITLFGLRHARNTLVGDASIRGISGGEKKRVSISEMLATRSLLSSWDNSTRGLDASTALEFVQALRLATDIVRLSTIVSIYQAGESLYNHFDKVCVIYEGKMAYFGPADRARQYFIDMGYEPANRQTTADFLVAVTDPGGRIVRSGFESRVPRTAIEFADTFKQSELAQLNRDDMQSYRDEFVGKPQRASIYSASAQAERAKTIPSKKSSYIISVPMQVRAVMLRRVQIIKGAKMAQVLSTVVFVVEAVIVGTIFLRLSSTTATYFSRGGVLFFALMFAAIFTMAEIPALFAQRPIVQRHAKAAMYHPFVDSLALTLVDVPMTFVTVVGFSIILYFVVDLQQSAGQFFTFLLLIFSMTITMKAWFRGVAAAFNDPAPAQTIAGLSTLLMVLYTGYAIPQPYMIGALRWITYINPIKYGFEGLMVNEFNTLNGPCAAIIPQGPGYENVSLANQVCTTVGSVSGQQTVNGLRYLQMSFGYLHSHLWRNFGIILTFMIGFIAALLLFTEFNTSTKGQTSVTLFKRGSKTAVIKAAASEAASDEEKPASTASSEKISAGADAREVIKEAPAVRDTFSFQNLSYVVPVSGGHRQLLDNVTGYVASGKLTALMGESGAGKTTLLNVLSERTSGGVVSGERFMNGQSLPIDFKSQTGYCQQMDTHLSTASVREALLFSAKMRQPASVSLAEKEAYVEKCMKMCGLEEFADAIVGSLGVEQRKRTTIGVELVAKPSLIFLDEPTSGLDSQSAWAIVCFLRDLADSGQSIVCTIHQPSGELFEVFDRLLLLRKGGQVVYFGDIGRKSSTLVSYFESHGGRRCDEAENPAEYILEVIGAGATAVATQDWHEVWKSSREMQTSLSELDAIHAEGHQRPPVEAKLLSEFPTTWGYQLYELFIRNAQTYWRDPTYLVAKLALNIVSGLLIGFTFFKAKDSIQGTQNRLFAVFMSLILTVAMTNQLQVPFFYMRGIYEIRERYSSMYSWTALVTSQILIEIPWNILGSSLYFVCWYWTVGFPSSRGGFSYLMYGIFLPLYYTTIGQAVAAMSPNAEIAALLFSFLFSFVLSFNGVLQPFSELGWWRWMYHVSPFTYVVESMVGQVVGRNPIVCSAAELVPVEPPTGQTCSQYLGPFIDAAGGYLTNGNATSQCLYCAYSTTDAFLGKSFNIFYSLHWRDLGILCAFIGFNIAAVYACTYLFRIRSGSYLNNAVGFLKRRLARRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMP2</accession>
    <name>A0A401GMP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0504880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614352.1">
        <property type="nucleotide sequence ID" value="XM_027758551.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GMP2">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMP2"/>
    <dbReference type="GeneID" id="38780356"/>
    <dbReference type="InParanoid" id="A0A401GMP2"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="352"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1332"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1422" mass="156524" checksum="BB60F84474F2C811" modified="2019-05-08" version="1">MSDAEGVREPRRSQRQKKQVAHFAVNSTLTKRKRSDATDQDANSELSDSEDNDEGPDEEDDDAPKTKSPAKRKRKATGAPQAKKPRKTKMPAPKATAAKPKKTATRKAKQPAPDAEDFDAEKVAKDTKISGDNPLFNAIMNPAAALQSTVEDFLEAMVRTPGLSLAELINCVLRACGCNDSVNEDEVVDYDGVVDALDNFTEGLKKDDSPVYPLTSKLSVFKKFRKSLSEFLERLIASSAELGSLYTSDLMPTLQTWVVAMSSSQLRSFRHTATVIALEMETALCDVAAAVEKEAEVVGRQREGERKRKAAAVNKSKGGSAREKELEGKAAEVRQRRTTVAEFLKEFVDGVFVHRYRDLDASIRTECVRAMGLWFKKYPAHFLDGAYLRYVGWVLSDADTHVRLDAVRALALAYEQTAYIGAAALQHFTERFKPRLVQMAVGDTELSVRVAVVQVLQAIDGHGLLEDEQRERLCLLVFDEEARVRKAVSGFVRGVWEECLEERLVGKKPNAKDKQRAEVKALGMLLVKWGKTLDKTTEDVDTEDEDASVIDEGSSSRKRAKEVASLLSSGQKGRTALAVEALWDEMEPVSDWETLLDVLLLDHSAIGDDSSSQDRGSGGSGKQPTGVDEAWRLEEVEEAVLLEMFVAILRKAQADVANAKKGEDETVSSSMTRALIKGLPRLFVKHQTDENRIADVLLIPQVMNLDLYLEMRMMTAYASLWDDVTKQFLSHSHPVVLGNAVATIRYMMDATSLSNTNSTKILELEDELSTTLRDAISGRDEIEVASFSEDEVLSLGAICARLAALIGIRDLTSWMEEDEGGKQSSAWDILNALAERGRLGYKEEESMIDRALQVLTLHIIWKARGLTAPDVEQSPEEARFTERLREQRESLLEKLVEFAVGTQSNTSEGVRRAAFQNLMHLHTLFYPGASIAPDGSRLPTASLPLELGDEVQYRCAGFVQAEIEHYAEQLEELTPAHDGQNEENDASDSNESDSAVPAKKKNTGKGKQPAKGHSEGSRMTSRSQLEEEYTFIGVITTFLRAIRIGVIHFRHASILLAHYGRLGSMFDLCSKAIVDILREEGMYKNNGTDVVAVICQALRESFTLVLEGVVQTEEHSVALAKALTACLIMRGAQLSVVRRLDSKYVVEIHTALLSWIGKRLAACESAKNKKSRNKALLFFKVLHPLLVSIDNRDSLNIKAHLDQVLAQAKVEVLATAKAWESYRAYEKRLTASTAKEKGAAAKPKKVPKKGAKSAEKITTDAEEDEAVERPENVPRAPRLRPRPKPAYQPARAAEAATDGEPEATEDEDDPFLGSAVPNVATPSSRPRRKAASGSNSPRKSPSKSPSRLTSISEPLTPSPDENATPVASRKRGRSSDAEELEGTLDTLGDGEDSAAASPSAEPSLSQGTQATELQIRRKRIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMW1</accession>
    <name>A0A401GMW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0505600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614422.1">
        <property type="nucleotide sequence ID" value="XM_027758621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMW1"/>
    <dbReference type="GeneID" id="38780426"/>
    <dbReference type="InParanoid" id="A0A401GMW1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="88" mass="9894" checksum="7037BA08BBB5A774" modified="2019-05-08" version="1">MRVRASLSAHPSSFVNGEGGPWLLQGSYGSCIASKYWPTFVTSRVLLSFDADERPPLPRINAKWRSLCYGGPCIFNRFCNRSKRLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN80</accession>
    <name>A0A401GN80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0507430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614600.1">
        <property type="nucleotide sequence ID" value="XM_027758799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN80"/>
    <dbReference type="STRING" id="139825.A0A401GN80"/>
    <dbReference type="GeneID" id="38780604"/>
    <dbReference type="InParanoid" id="A0A401GN80"/>
    <dbReference type="OrthoDB" id="3247499at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="373" mass="40740" checksum="99A0E17468992AF9" modified="2019-05-08" version="1">MYSQLPNETLTIIFENLQPGVLAEVMRASHRLRAVTERILYANIVVAESLSAASLSPVHTINCCETLVAHPHLADVVRKLAVRWHTDPGPREPYLTSVIPAVSTLNQALCSLIHLESLELAFGLTGAPLSLHDVLTHCTFPALRLFALSGIGRGTLPPKFHAPSPPIAWFLADTPSIQHLRLPDLHERVTLAPADLPFLATFRGSPIAAASVIPGRPVHSLALVGHQFVTEPDLEHIAQSAVRIRWLDLSGMSVTPILLRDISRHLTSMEFLKVRLALRHTLHHSLSGISILAGLTPVLGAFPLLRQLDLSPTSVIEGVGSSNALEESTLCTTWARSCTALRHIIFPSHTEWTLAPEQVWVPHAQVPARYTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNY5</accession>
    <name>A0A401GNY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614846.1">
        <property type="nucleotide sequence ID" value="XM_027759045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNY5"/>
    <dbReference type="GeneID" id="38780850"/>
    <dbReference type="InParanoid" id="A0A401GNY5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="49" mass="5600" checksum="3A9C0A53A7E0BDB4" modified="2019-05-08" version="1">MLDLRKAATPDDESGMSQLTTIHFRQGHPALTSDMEERDVLEVRFSTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPM8</accession>
    <name>A0A401GPM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615098.1">
        <property type="nucleotide sequence ID" value="XM_027759297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPM8"/>
    <dbReference type="GeneID" id="38781102"/>
    <dbReference type="InParanoid" id="A0A401GPM8"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="428" mass="48755" checksum="170F4A27084FB87E" modified="2019-05-08" version="1">MLPVEMWFSVIDQLRDDPHALAACSLTCRSWRTVAHLHLFYTVLLKDISAYMRFWRLLERLLEKFPDIPPYVHDLTIAMSPTLAVVGAHTSLDPVMPRMLLKLDHVEVLTLVHWRAIHMSEDTRSNLQAFFPSLRVLNLVVRERLRQAARRVPQAHRRALSSRQAGPPFLDGPPLQDVLGASLHSAMRRTIDAVTVFNDSQPVIPANGWILEDPFEVRLRRLEAMWDSAELVTILGLSLGDLLQASGTALEHLNLAIQSTFVSPRGHLTLSHNPNLRSLTLTDVNVRGRSASDWLREFLALIQLTHASLRLQEIGLNLAGPSDVPLLQGWSLLDRQLADLAKDRRELVITFRLRPMRPPLDLDAWTRDTANEVVKRLPYVRAGRAWLRVVGAPYRYEMYPFEMYPQYGTASSSEAATKDEELELWFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPX0</accession>
    <name>A0A401GPX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0601770</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615112.1">
        <property type="nucleotide sequence ID" value="XM_027759311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPX0"/>
    <dbReference type="FunCoup" id="A0A401GPX0">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GPX0"/>
    <dbReference type="GeneID" id="38781116"/>
    <dbReference type="InParanoid" id="A0A401GPX0"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="291"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE84199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="599" mass="66864" checksum="6882281D061E1CAF" modified="2019-05-08" version="1">MVTDKTIRVGRAKSYPNEVWWFVSCFIFTVAIFQYGSWAISKLLRRRAAAQEALQNDTEGGGAGPNRRFSVRRLPLAILNAYRVVAFRWTLEIGSWYTLNFAEVFVTCSYIIAIFIWEFGNTTDLEGHKLDMTYWGNRAGTIAASQIPLVTALGTKNNVVAYITGISYDKLNYIHRMTARVMFVLLWVHGGAKFNSLDPGEIDASWVRAGILAMAAFSLLILVSLRPIRANVYEFFFLTHFSMVLIFLLGAYFHAKDQNMSYYIWPSFIFWALDRFIRLMRVVVFNHQYFWFKSSGSLDGTVELLSPHFLRLRLSRPPHFHWRPGQTAYLIMPTVSASPFEAHPFTIASVDTSDEMGGDLEKKELGETTPFWKELVFLINVRSGVTKRLATIAQTGAKVKVAVDGPYGFSPDLSVDDTVVLISGGSGITFTLSSFLGVVNDVRNGKSSCRKIIFIWAIRDAAHIEWISKTLSKALEVAPSYLSISIRIYVTSREPLPATNPKAWDDDSIHGSENSEDKSRAPSLLESPAVQVVSGRPDLHILLRDEALANTGRMSVTVCGSQAIARACRAALRFPVSGPKSILQGCASVVLHVETFGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQA4</accession>
    <name>A0A401GQA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0603070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615242.1">
        <property type="nucleotide sequence ID" value="XM_027759441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQA4"/>
    <dbReference type="GeneID" id="38781246"/>
    <dbReference type="InParanoid" id="A0A401GQA4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="248" mass="27836" checksum="91A75A480E11977D" modified="2019-05-08" version="1">MSVPASPTLVNGVPSRAQTPFIRASSPSPSIKLSHASDEQEFATRLISAIRVPVDFTDILVALQNRPQDRQAVVSMQRALEMVEWMQTARQELIAAEERMSRARTRVDQVWSLMRSTVTRTAQEIWREHGDEDIGHILGYTTNGIPASTPLDDLHYRNHLSRPHPLLHIAVIPTGMDISPNKDHEPTGGHATDAEEIIMSATAPDDDENHNISCGTRNVRRELMLQRSSLVAHLFFSFSLFPLRYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQC2</accession>
    <name>A0A401GQC2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0510030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614857.1">
        <property type="nucleotide sequence ID" value="XM_027759056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQC2"/>
    <dbReference type="GeneID" id="38780861"/>
    <dbReference type="InParanoid" id="A0A401GQC2"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="114" mass="12532" checksum="8BFC651E6D13EFD9" modified="2019-05-08" version="1">MSTTALPLHKFLVYAPDQTDVGALERRLSVRASHLENATGTARKGLLQTGGPLLSPESIASPTAEKKMVGSLMIFEADNIETVKKIVESDIYYTSGVWDKEKLVILPWIQATFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQL8</accession>
    <name>A0A401GQL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0604290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615363.1">
        <property type="nucleotide sequence ID" value="XM_027759562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQL8"/>
    <dbReference type="FunCoup" id="A0A401GQL8">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQL8"/>
    <dbReference type="GeneID" id="38781367"/>
    <dbReference type="InParanoid" id="A0A401GQL8"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE84450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="151" mass="16024" checksum="E4313F93F975C9C8" modified="2019-05-08" version="1">MPPKKTKAPREEAAVSLGPQVAEGELVFGVAHIYASFNDTFVHVTDLSGKETISRVTGGMKVKADRDESSPYAAMLAAQDVATRCREVGITALHVKLRATGGTGTKTPGPGAQSALRALARSGMRIGRIEDVTPIPTDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR88</accession>
    <name>A0A401GR88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mug135-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0607510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0612 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615684.1">
        <property type="nucleotide sequence ID" value="XM_027759883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR88"/>
    <dbReference type="GeneID" id="38781688"/>
    <dbReference type="InParanoid" id="A0A401GR88"/>
    <dbReference type="OrthoDB" id="2685013at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013902">
        <property type="entry name" value="Mug135-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08593">
        <property type="entry name" value="Mug135_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mug135-like C-terminal" evidence="2">
        <location>
            <begin position="119"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="203" mass="22746" checksum="92E36FFC465532ED" modified="2019-05-08" version="1">MVMAPVHLPPPNAAHISLPAQASDPPTLADLTNASRYYDKLSENKRMSTSSRRVTDNDLGQALLYVHKLCDRSGRQGDDAIPTAGIIRDIIRDSLAPLRERVDMLMEKVDTLLEISSQAYNAGCGSGEYRNYKVIPFRNVDGEVEQPEEHDLPLLTTSTAINDLSNDQLNEYMDRYRIQRAANLSRESKLRRLRAFVGCTVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSB8</accession>
    <name>A0A401GSB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein MMF1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0703180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616045.1">
        <property type="nucleotide sequence ID" value="XM_027760244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSB8"/>
    <dbReference type="FunCoup" id="A0A401GSB8">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSB8"/>
    <dbReference type="GeneID" id="38782049"/>
    <dbReference type="InParanoid" id="A0A401GSB8"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="125" mass="13577" checksum="3CD45B9719B895FA" modified="2019-05-08" version="1">MKTTVNNPDAVPPLPVYSHATICNGMVYVSGSIGCDKEYKLQGDVKDQTRAAIGNMRKISQAAGADFENVVKVNVYLTNIQKDFPLMNEVYHEHFPTNPPARTCIGVAALPLGAEVEVECIAEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSD8</accession>
    <name>A0A401GSD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate-binding module family 48 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0703120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616039.1">
        <property type="nucleotide sequence ID" value="XM_027760238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSD8"/>
    <dbReference type="FunCoup" id="A0A401GSD8">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSD8"/>
    <dbReference type="GeneID" id="38782043"/>
    <dbReference type="InParanoid" id="A0A401GSD8"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="4">
        <location>
            <begin position="326"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="400"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="540" mass="57148" checksum="7DBF14642763A417" modified="2019-05-08" version="1">MGNTSSNPAAAANAANPQNTPFPVRLGSPAPPSPNIQQQHRVHRSLRSKKKSLELPDLASLSLTPASSSPSSVSPHPAYRRPPASSPIPIPTSANPPQPTFRPQNNLPSAAHIHMHDGSQANGHRPRHKSYLSSAYPSTRSFISGGDQASPPREEPIRPVFVPEVVYSTLPLALVKAEEETKLEPVAVKIIWRGGGKSVVLARAGDDNWQGRQPMDFDPQLNQWFTYVPLLPGTHHLKFIVDDQWKTADEYPTASDDRDGSLANYVAVPFPAAISSPNVVPASGSGSCTTSPLASPHHSHPNQFNSFWSDASSAAANGVPGHTEGRGKAEAEWTTTIPPELVAAAAEEETYLASADSPAPSHSSVGGGGVPAPNIPPAPVLPRHLDKLILNVRPAAVTAPTLGASERDRGRRGGRERERSRRDKDSRARPSNLGMTSSAVQEDAEHPASLVLLPVVTASGTDLTAGMPVPLSSPAGEAKGAGTRLEATSGVADDASVLPVPSHVVLHHLSTSAIRNGVLAIANTTRYKKKYITTIYYKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT59</accession>
    <name>A0A401GT59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0701060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615837.1">
        <property type="nucleotide sequence ID" value="XM_027760036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT59"/>
    <dbReference type="FunCoup" id="A0A401GT59">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GT59"/>
    <dbReference type="GeneID" id="38781841"/>
    <dbReference type="InParanoid" id="A0A401GT59"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="228" mass="26069" checksum="D6EE0BB1E17DD2D8" modified="2019-05-08" version="1">MDPGNLEYINQLLDKDVELREKIKDQVTEFDKKTRTLCGMLNKIHATPSDQMPVLLDSVRPVLESCRETTAALADLVPPNQFWRWKDMWSISLRNAVFGATLVEFLRSGSLLTLPRVSDVLGIKVEWKDKFALTAEDYLHGLITLVNELSRLAVNAVTLGDYEQPIRISIFVKDLFAGFSMLNLKNDTLRRRYDSLKYDIKKIEEVVYDVSLRKLAPSHPHDKAHAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU03</accession>
    <name>A0A401GU03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0802370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616628.1">
        <property type="nucleotide sequence ID" value="XM_027760827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU03"/>
    <dbReference type="STRING" id="139825.A0A401GU03"/>
    <dbReference type="GeneID" id="38782632"/>
    <dbReference type="InParanoid" id="A0A401GU03"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="355"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="636"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="983"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1137"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1142"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE85715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127863" checksum="C025F527DC6608F2" modified="2019-05-08" version="1">MSTAASSTPSLTPSRAPTPQVPTQPDHFYGSENAQQLPLSPDSDGKTWLDPEDDPSAQRGIPVFKPTVEEFEDFEAYMDRIECWGKKSGIVKVIPPKEWTDALPPLNPQLARVKLQNPIEQHMLGSGGLFRQQNLEKPRVMSVREWSELCEKEELRAPGIDDVGLRARATNGSAKARTRRARKKAGKSETAEPDADTHIKEEENNSQAHLSDGSPQPFASSSCAVVSATPVGDQYSGLSVEHVEPHSTVSVLDSVSVRDTPFRLGEEETEEKPNVKGKRVGQSRDARKASLAQRADKDKKFLEKFDPHSDWLPPNTTPFDYTPEFCKELERRYWRNCGLGRPAWYGADMQGTLFTSETKSWNVAHLESALSRLLPASSQGLPGVNTPYLYFGMWRATFAWHVEDMDLFSINYIHFGAPKFWYAVPQARATALEQTLRGYFPKDSSLCRQFLRHKSFLASPTLLSQSSCRPNCLVQHAGEFVITYPNGYHAGFNLGFNCAESVNFALQSWLKFGQDAQVCSCVSFSVRIDVKKLMHDREAERAQEKTSQPQLKSSKSGRIKNESESSREQPSRKRKVEGSDGSCKTKKQKTKTTKGGPAEASSSKLATKVTLKLGPKPKETEVFPCCLCVSMNQDRVLRVQDPPLWRKEGESVPGADPKTAVWMAHEDCANIVPETWVDEVEIGEVRDDGTRGKERVVFGVDAIVKDRWNLKCSACTKTRHKAHGAPVQCTKGKCPKAFHVSCARDGAASGIVFNVLREVEKEVVIMGAQEMPTTLNPPQMVVDVPAIADGLTMPLDQASLVPEANGLDFSGTPTIGMSVAPVTDSAEPSSSHVYKFVKKVEVQVLCSQHNPKIAQEKKELKQQRIRDDLVALPPMTRIKLRVSAGVFEVSLLRVIEETNSVEVLWDRGLKREFKWGSVVFGNTEGLTVGQKPTEAAPEPVQLAAQLPTLQPRAAFPRFSTATPPVDARNQAVSPLSIPLQPTLSLSVPSPGPSTATAPVYTPPSAPYPPRPNTYQYSSAAWKYNFPPPNATPSYATSGPSTQSYQYASTAYQSAGTYRGHSGYNYTPNQYQSRGLQWQRPYTGPKPNAYGETLTSTLTAQAVPYAPPAQAVPYYPPGQTINDKAPVGSQPQWASTLAMSISNPPPAAPPSSQLPPATVTPDAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUW3</accession>
    <name>A0A401GUW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0805390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616928.1">
        <property type="nucleotide sequence ID" value="XM_027761127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUW3"/>
    <dbReference type="STRING" id="139825.A0A401GUW3"/>
    <dbReference type="GeneID" id="38782932"/>
    <dbReference type="InParanoid" id="A0A401GUW3"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="49820" checksum="BBF25BFB2FD0CE15" modified="2019-05-08" version="1">MSSTTIDVDSADTNQINYKPTADYPWYFTHSDNQQVYDSTLSETHGPSSAVFDFTGTAVTVYGTLPSPQNGSAMPVSSYALDGATPISFVPSVVTTEVDGVSFFSISSLANTHHELVISVTSASAAAPYLLDYIAYVSVASSSAPSPPSTPPVQPTTQPSASPTPTPTPTPTPTPSPTPTPSSQTSSQASPSSSSSSPYSSQSSSVSGSSLSASTSLSALSSVYQTLTNTDVTHLSSTALSATSSGSSSSSSASQTALGAAAHTSSTSKPVGAIVGGVVGGVAGLALLLAALYYFFFRRNREMVTPYVHPESTLEGRQPQLPPAPTYNPYSHPSYAAPGSAAQMAEPALASGALLAWQSSPSVHAAAASPDPSAGGGIAYYPSSSEHRSSTSAFAPSAASASAPLLTPTPPSSIGGSSSERARRARGLGAGAGSLGTKEPSSSFMHVRNDAPAPAPAGQAQTPYEDSGLRFAPRVPPSEVGTVDPPPPLYTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVE9</accession>
    <name>A0A401GVE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617089.1">
        <property type="nucleotide sequence ID" value="XM_027761288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVE9"/>
    <dbReference type="STRING" id="139825.A0A401GVE9"/>
    <dbReference type="GeneID" id="38783093"/>
    <dbReference type="InParanoid" id="A0A401GVE9"/>
    <dbReference type="OrthoDB" id="3244156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="552" mass="60460" checksum="172D45D9B9622B29" modified="2019-05-08" version="1">MMADYTGGIQFLDAQSFHLDPNFTSNDTPYPTSPGIRRTSHVTHASSPSWISSFPPYSRPSSGRPPLPSPAINTRIMPDSQQQKILRLVTERDNGEQPPPEHLPEMDAEPEWDPFDTEEMIVGASGESEHVEEGYGQPVWNSEPGPSEGPAEPAKHKGKAKTFVGGFVKRLGRLPRAISRGQLLDRKPPRKGTLGLGLSDEPESTTPLPRYDDPGQPVPNLSNVHYVEGMEMPVAPPSGRFHEQQAEQFSWEQPSGGQLSYSYEHPSAQLSYVDEEASADIPGNNLDAPLENPYEHSQVPGQQQDDATVMAGRGHITPPPAAFLSTPVAVNSPVQVNPLPTADYVRMESRERPLDDSFSAHITRARTLLVDLRNLPWISYPVAVDYFPSQSSRARSPEAKPNSWYYTTRQHQELDLIGTSPAKPLVRPHIHRGDDSTRMRMIPHAPTTYGSLSEAARQVGDSPATVRGQHSLAYSQPYHTPPAHTYPSPESQVGTDPTPVPTEIRQVLPAITIGTPPPSVLRTPISPGGSNTPTRVPYSVISPNSVDISLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVN2</accession>
    <name>A0A401GVN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0901290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617163.1">
        <property type="nucleotide sequence ID" value="XM_027761362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVN2"/>
    <dbReference type="STRING" id="139825.A0A401GVN2"/>
    <dbReference type="GeneID" id="38783167"/>
    <dbReference type="InParanoid" id="A0A401GVN2"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="33055" checksum="5DCA999A31A22DF4" modified="2019-05-08" version="1">MVACSTIHRASLINSSIHSPALMQMLDISVTRALIEHVVDNVVETVDFAMGRASTSTRGRSLSRDSYHAAFTVFAADVIQKAEVTVPVLLTTLVYIARASPHLQISLEKWACERVLLGALIAANKYLNDRALKNVHWAICSGVFGKRDIGRIEREFLDVLDFELGVSEADLLAHHENIMMFSQRTRPTRTRTRARTPLPVRRACSAFSSDSSDSSDSSDLDSDSDDSFASSPSPCTPPHPPYSPTPAKPSLPHIADAHVDAVQSHQMSAALELLMTFPMPVSHPRKSTHHHPRFTAATAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVU7</accession>
    <name>A0A401GVU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0804070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616797.1">
        <property type="nucleotide sequence ID" value="XM_027760996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVU7"/>
    <dbReference type="FunCoup" id="A0A401GVU7">
        <property type="interactions" value="425"/>
    </dbReference>
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        <property type="term" value="F:protein heterodimerization activity"/>
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    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
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    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="Histone-fold"/>
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        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
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    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
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    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="167" mass="18452" checksum="1F82A31A9E90C01B" modified="2019-05-08" version="1">MKNRNKSTKFPVARIKRIMQKDEEVGKVAQATPIVISKALELFLGMIIEEASKVTAERGSKKVEAYHLKHAIDTVEMLDFLKELVEAVPDPSAGGTISLDLEGDGRKKRSKGKGKAAAALGEPSNGAGAGTRRRRKGKEREEREPEERDVPEEEEREEREDEDGQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWJ1</accession>
    <name>A0A401GWJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617047.1">
        <property type="nucleotide sequence ID" value="XM_027761246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWJ1"/>
    <dbReference type="GeneID" id="38783051"/>
    <dbReference type="InParanoid" id="A0A401GWJ1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="96" mass="10791" checksum="06A9EE506A0C75A9" modified="2019-05-08" version="1">MVDRAPSAREKSIKTDERYRPRRRHLVSGNREHARETADAPLTVPVAKVWCDGRSGLCEERGRGHHFVLQYGAPKGRCEMLGLKRVGRDLGLGSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWN0</accession>
    <name>A0A401GWN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0905000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617534.1">
        <property type="nucleotide sequence ID" value="XM_027761733.1"/>
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    <dbReference type="InParanoid" id="A0A401GWN0"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="208"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="411"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="757"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1004"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1162"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1069"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1207"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE86621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1225" mass="130889" checksum="25613DB24F2DA536" modified="2019-05-08" version="1">MTNGIINGTGLENQFASLGINGTKSAYVPPHLRSSQRAASSPTLPTNGDGWNDSRSSTPLSTPPNRGYGGGRGGQYDRTASGAVGGRGGAAGGDRWGAQPTSNWTGHTPRGDGQRETFGYGVWRDGVHIPGGRNVRMEKELFGDDDDPSKLHTGINFEKYDEIPVEATGAGVPEPVTAFTNPPLDLVLLENIGFARYATPTPVQKYSIPIVALGRDLMACAQTGSGKTGGFLFPILSASFTNGPRAPPADSQGGGYGRTRKAFPTALILAPTRELVSQIHEEARKFCYRSWVRPAVVYGGADINQQLRLIERGCDLLSATPGRLVDLIERGRISLANIRYLVLDEADRMLDMGFEPQIRRIVQGEDMPGVQDRQTLMFSATFPRDIQMLARDFMKDYVFLSVGRVGSTSENITQKIEYVEDNDKRSVLLDVLSAHVGGEGGLTLVFVETKRMADMLSDFLLANHLPATSIHGDRTQRERETALQTFRSGRTPILVATAVAARGLDIPNVTHVVNYDLPSDIDDYVHRIGRTGRAGNTGVSTAFFNRGNRNIVRDLLELLREANQEVPPWLETVAHEGAFGGGMRGGRGRGGRGGGRSSTARDFRASGAGGAGGGYSGGGYGGRGGAAGYGGPTQYGGYGGSGYGGGGGGGGGGGSWCLQQVMYRALSPIFDVPEFPPLRRVKPLPKRRRTSETLPHDDAENIVPSAPTMLDSCTTTEELIAHADALTAQMALQSYYMPVLGGVQDLFKGDTNSHTSTPLNLGGMYGLGDPRGHEDDDSGDGDYIDHLQQPGNTKKRKVPANMSGSLHGHDETSGNAGDDEEPTDRAIPTGARSDRDYDVVGGQPPQSSPGTLAQKKGKMSKATLAGLQHKEMLKSRKRQLAAVLGALSHGDTLALDQALSGSHPFTTAGLLGDPKLVRMRLSRRRGPRLARAYRAFHASIPSLPDNREAALPLSDFSFVCHSAASDRLIATKEEVAVLHARFEQELARQAAKAAEAAKQAAAALNNGPFAKRNDTSKQGRGRGGADPNAGSLDQSPSSGKDRGGKKKKRSALANASNPHHLRNYVPSRLPSQGQANTAKASVNNQNLVSPLPLRFLSAEIPPRRRKGSERVVTPVSTLSDPADEWICPFCEYGLFYGDELGYQRAVRNRKKILRRRRRARERAAAAASGTGPAIAPGKNTPVNEEVYPGYDVPAGGDNTPVAGKQARYKEERDRGGHSMTASALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWR3</accession>
    <name>A0A401GWR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0905410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617574.1">
        <property type="nucleotide sequence ID" value="XM_027761773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWR3"/>
    <dbReference type="STRING" id="139825.A0A401GWR3"/>
    <dbReference type="GeneID" id="38783578"/>
    <dbReference type="InParanoid" id="A0A401GWR3"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="353" mass="39319" checksum="74917964798B1FD4" modified="2019-05-08" version="1">MSLEVDHTAKIDAARSLQAQLQNTRLYIVGYREQFDTHHAAAAESGSSSLYETRTGLTDPAVVAVDVASQIAFLRKLKIQYLEQKAKDQYIKTIVSPDAPNIDANDNEKLRVVNEAKKEALKAAKAHLAEKDGDIRKFAPLVEQDYNKAKLLTDEAFSLASQILDARLTLTRLRSAHPLPRLTIPAANAQLDVQVIEMQKLDDALQGVNENIERVKEAVKDGAREFERLRVERADMEKLVQAEKDEGEDETVIGLYDWYTASLALHRSLLSLETFHFASENELHLKYAIPRQGEARRREVQITLLFVPNTRQLADAQIEGLSGDLGDIVGAHIQANDVPGLIAAVLARARAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXH3</accession>
    <name>A0A401GXH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617793.1">
        <property type="nucleotide sequence ID" value="XM_027761992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXH3"/>
    <dbReference type="GeneID" id="38783797"/>
    <dbReference type="InParanoid" id="A0A401GXH3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019213040" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="52" mass="5748" checksum="F7F8148555DD69AA" modified="2019-05-08" version="1">MILLDLCSLEFVLKVFAEVAAISKPADYHGKQSMRDQMLQTSHPTPAVVVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXK8</accession>
    <name>A0A401GXK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1002100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617878.1">
        <property type="nucleotide sequence ID" value="XM_027762077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXK8"/>
    <dbReference type="STRING" id="139825.A0A401GXK8"/>
    <dbReference type="GeneID" id="38783882"/>
    <dbReference type="InParanoid" id="A0A401GXK8"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="784" mass="87399" checksum="7F4FA81D0B412E8A" modified="2019-05-08" version="1">MSSHLRLPHALLDFTLTRATARLHALNGKSVAVNPWRRHGHSAVARVSDDSYYPARSENIEDRSLYARRKTSHKESAIVPQKPSLAKGSLTELEKRVLKLETMLESEEALVEIPTYTESQLLEIYEDLLALPPEDTYSTKQAALVDERAQEQEDVSLMRDVVGRLLETSEQESPTSDSQGQYSAVISRLQEIADDMGTVRIIPSESSPARQDIPTGILTNDEWSALTRTCVRAQDGQAAETVLQLMKRAGSPVPEDNVNEALALYASAGDVPNTERFLHTFIIGSLSDRQRDLHVKSRLKASPPDVMPTEALSLLHAYEERGTSAPQKSYTRVIVALLQSRSASSHAYAYAWDLFAHMRYAAHPTPDAALYTLMISACGTPNGPSQPERALDLWTEMTVDQGIPPTARAYSAVIQACARSGQKQFVHEAFRLAKEMLDADRDARGRAAFHPNGQLFRALLEGAKRVGDLVRVRWILAEMVRDSAEGDLNEVIMTHVFHTYAAYKPPFRRAATVILDKKKALTPSGEKSEKASSIYEENDTGQAVAGSPAGTLGPEYDDVLASLPVESSKSSFAHIPPQSKAEVIREARILFSRIVEDSDISHQKREEEFADPDVASLPRKFRHVQLTPRLLNAYLSVENTHAPFEDWSKLYRTLFTELHLPWSAHTYIEALERCTRSGGQERRMVIKWAEDVWSEWQEVEDRWRSGKVSEGDASQTVNARLVERANIAMIRLRATSRDTGRALDLVKTFAEHYPPDAGQGLLSGSLVLWKSPTTLSHHFSPSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXP6</accession>
    <name>A0A401GXP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0904430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617477.1">
        <property type="nucleotide sequence ID" value="XM_027761676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXP6"/>
    <dbReference type="STRING" id="139825.A0A401GXP6"/>
    <dbReference type="GeneID" id="38783481"/>
    <dbReference type="InParanoid" id="A0A401GXP6"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="361" mass="38604" checksum="5BF2E8E7E91A6EBB" modified="2019-05-08" version="1">MTIKLKPSHSPDPPPFSWDDVPSTPPPPADISSPPSPPTSWLSARDMKMFGAEPLREEIGLVKCIDCGKPVLRSAILEHAENCAKIRNGGKKGAKGKANGEADTDTTKKGKKRKAEDEDPTPDDPSLPKKKKSATKVTKGRFKGPVDYDKQCGVINDKGLPCSRSLTCKSHSMGAKRAVQGRSKPYDELLLEWNRLNNPNWVEPVKKESKAERKERKEREKAEKKKLAMEAAAAAGIELSKKALNTVLGTSGTKKGKKAAVAAAAAAAAAAVAASTMGPGEDVYENLDDIDSEGEVDSLVHAVRFAQNRGVTSVPLAVPCDAGSWFVGRRERLRSCQQLLSQALVSKSASSTSTVTVGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXW7</accession>
    <name>A0A401GXW7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1003130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617979.1">
        <property type="nucleotide sequence ID" value="XM_027762178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXW7"/>
    <dbReference type="STRING" id="139825.A0A401GXW7"/>
    <dbReference type="GeneID" id="38783983"/>
    <dbReference type="InParanoid" id="A0A401GXW7"/>
    <dbReference type="OrthoDB" id="3222238at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51011" checksum="47A8C8015F51542F" modified="2019-05-08" version="1">MSSAAGKFDGCATMASIFITILQNEALTARLLEAVLHADRGLGSLSWLARTCKALRDPALTLLWRDLNSFEPLVTLFPQTKSRVFGSMRQKDWDRILGYGSRVRSISYIDSGTPSTLFDLLEKHTNGPDHIMPNLTSLSYQSTYPPKSKHCTLLLGPKVQTLNVKVQWMRYSTLVAWRNVSASAPAHNLKSLSSLSIEVSGLYNFYALIKDVPPSEVALEHLSLVSAKGIEPDPLFMLWVADLPKLHTLGLAVKYGNVSASAAVEYHRNTYDTIPEPTSSMRTSESHVPDVKIPKFGRLRKVRLIGTRTDCLVFLRDLSGPQLHHVELELVPAESDLDWHRMCIALRMHCSSSLHTLRIHSPHVGYVQEPIQLEIWQLGPLPHLRCLEIDLPDVIFNDSSIVDLTVAIPSLEEIRLAPFMRFPHQGTEMYRFTWLYSERDSLTPSEMYKAIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY21</accession>
    <name>A0A401GY21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1003720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618038.1">
        <property type="nucleotide sequence ID" value="XM_027762237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY21"/>
    <dbReference type="GeneID" id="38784042"/>
    <dbReference type="InParanoid" id="A0A401GY21"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="111242" checksum="A8ABF2645A5F87D8" modified="2019-05-08" version="1">MVSRSTERRHRAGKVAPRIHALSALNRQVFKNLKKHQAAVEVELDIEYSETDDAAPDVRALDEKLDAVPIPMDVGYAAGPNGPQYRGGDEAGQEVEPEDSAVQSAVATAQTETWCRHTQCAQVDDEEGETSDDEDEAEDYSSESNSDSDDDTDDEGGLTVWDWMGAEFEARAMAIEEELNEEDKAMLRAFALKADSHMMTQTYVKLPFAFPNEHIPTLGQAKSRIAFLSGIKPQLYDCCRNSCCCFVVPHAELETCPYCHLDRYRADRKPYKQYTYLPLIPRLKAFHVNTLMAKSMQYRAEEHKHDLNVIKDVFDSEIYRSLCGQPVIVNGKPLKHRYFEDSRDIALGLSTDGFAPFKRRKQTAWPLIAYNYNLPPEVRFHKKNIIPIAVIPGPKKLANFDSFLWPLAEEMLRLAVGVRAWDVLTAAMFVLHAFLILVGGDIPAISMIMCMKGHNGYAPCRMCKIVGVQVPNAPRSPYYVPLDRSRHPAPGAIISYDPAALPKCTHEDILTQACEVQSARTDAEAERLAKAYGIKGVPLLSCLSSLSFPLSFPYNFMHLIWENVIKNLVLLWTGEFKGLDEGNEEYQLHPDMWTAISATTAAAGSTIPSAFGPRIPDPATDKSASTADSWSLWSLYVGPVLLARKFTRPKYYEHFIELVKLLHMCLEFEISRQDIAIVRAGFIKWVTTYERIYYQHSPERLGICPVTIHALLHIADSIETASPVWACWSFPMEHFCGYLQPAIKSRHFPFASIDRYLIDSACLEHIKMLYGMEKELALKPTASMSGLAVAEYNRCLLLPPHRTADMKTTPLIEKIVGALATRFNVTARVARHALPEQIKLWGKVRILPDGDTIHAAALSKPREDRCDATYVRYEVLVDKNARFHCRRVALEIHTFYGQLQHIFAVRLAPSQPLQLTKPTTLILATIKSCRIERSHNTLDIHFFSDTGAVDVIDISCIQCVIGRVPDGDHWAIIDHSGSLACAVYADEVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY50</accession>
    <name>A0A401GY50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="12" type="ORF">SCP_1003690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY50"/>
    <dbReference type="FunCoup" id="A0A401GY50">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GY50"/>
    <dbReference type="InParanoid" id="A0A401GY50"/>
    <dbReference type="OrthoDB" id="204958at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="244"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="524"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="485"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="322"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="386"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE87122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="616" mass="69351" checksum="E607A6ADE4169DA8" modified="2019-05-08" version="1">MAFFARPSSSAVKIVAPSVTSPPPSPKPTSKRDATQRQCRNILIYGSCKYQDKGCIYYHPPRDTPSPVLPESPVPSAALPAQAVNAPVFVPKTPHYPTSPPTPVIVPLQSPPSSPSPSSAPSDLSYEHHEPFNPFASDDEVVNDGSKVPAVNPYELPSDSMLGYDPANMVDSFYTPPYYAQQPLNYHLYTQARPEVLAHKYFISDSIREELQRRSETIRTALVPDMMLPEEMQGYHSLVPLEPSTGDRRKFGNWYSSVYRATNSADGLQYVLRRIENFRLMQQTAFTAIENWSRLRHPNIVSVQEAFTTRAFTDSSLVVVYDYHPNAQTVYEAHIKPKAPQFQNGRLQTQSNRIPEQTMWSYVIQIANAIKAVHDSGMAVRIIDPTKILLTGKNRVRIGSCGVVDVLMYESHADIAFLQQEDLAMFGKLIISLCCNNPAPMNNLVKSMETVGRHYSSDLKSVALFLISKPGPHKIIGQLFDMIGSRLLTEMDEMQNAVDRLEGELLTELENARLVRLLCKFGFINERPEFAREPRWSETGDRYIVKLFRDYVFHQVDEQGNPVVNLSHVLTCLNKLDAGTDERIMLVSRDEQSCLVVSYKEVKSCINSAFSDLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY60</accession>
    <name>A0A401GY60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clathrin-coated vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1003790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618045.1">
        <property type="nucleotide sequence ID" value="XM_027762244.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GY60">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GY60"/>
    <dbReference type="GeneID" id="38784049"/>
    <dbReference type="InParanoid" id="A0A401GY60"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1826"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1987"/>
            <end position="2006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2006" mass="217919" checksum="4FBFA9177AF0535A" modified="2019-05-08" version="1">MPTESLLCEPIDESNFSNENGEIYLFQWLASTEKAVRQASTADLKSSQGDLEATLVKIVTAPEPYPLPGRPVRNLIAKCLISLYTRAETKTLFDTVQAFLKIVGDSKTPHKDASRVAALYCIGELMGVFGSQVMSLMGEIAAVTLKLSKSSSPIIIRYHALCALEKSMTTAKRAITDSVAKDIIKQMRHHLGDKALPVQRGACNVLILMYPSGDGTRSVSDVDSIISLCVRSLENSDQLTRRSLSKLAAHMLASTQVPRVVPVVETSKKGKKGQNANEDEEDIAPVPHVTAEEAKPVMTPTEMLNQLSIHFNRPQASRKTRIGIFDFYAALLALLGSSFVESNYPLIVNHFMTEIVSNPRNSSTRYEVLSIRSFVEILLRDLVGVRMLGEQAQITAIQELSNLYLKRWPAMMPGQTAPNSLCLAIALREVAGLLRQLGNAPPPVQDALVDPLLTLLSHPSHTIRVSTAWALRCFCYSTPLRLPKVLLSIVEMLQRDLTSLTTPAAPADIHTRALGHAYGLAALLAVIPERPLYVSYDISAKVFDMAVQLLKRAGEHEVKIARTEIEIAWRCIASLMTLGPNFLRAHLPQLLVLWRNALPKPTSKDGAAGRSPMEWMFLLHVRESALGAVHCFLKYNSPTLVTPDVTRRIASLLSNALQFANTFVAHRVEVNPEEPQAGVKELSLEGREALLRSRIFLCFSSLGLSSVTESIQSSLLQSAISLFASPDGYAGSSVQAAIASSTGAFTSVWHSVDGYAYGVTDIQIDDNDTGKGLKAWMNRDGIEISINDMFQKPIIGSCEHDPLFLCQLNDVEANHRWPEPAPPATAAVNAAIQLFAQLLPLQDLTVSTRTLTQLVELTGKSERNLGRKAAVSVNATVALVLALRQPVTARSRQVLGNAQITSALSSFLKDVLVDGDLVLRKASSEAIGRLANIAGTNFLTSQVKILVDQVVTNRDPLGRAGCAEAFGAIHAYVGGLAAGPLLKTTIHVLMSLINDPHPVVHFWALGALARVIDAASLAYAPFVPSTLGLLFKVYMMESHEPEGGGLNHTNLSGDLPTYQVVCQNIDAVITVLGPDIQDSTRSRTLVLDLVRQFIDEDDDGICVEAINCIQHFLMFAPEYVEVPDLVMRFRGYLSSSRRPLKLASINALYQLVQKDAFAMSRLGGDQLVEELFAMLDDDSSVDGVRNVIVSWLHQTVIHNPSAWIDLCQRIMSRTTASQQVADAAAKRGDLLDDEGQSLSVGSAQDSGAFGGARSTSRWRTQLFALQCLHSICMIVRQSSRKEHLDLAFARSQGLPVAGLLVSRVPDLIKIAFTASAAHVTEIRLEGLTVLRDIIEVFAKTPDPDYSESLLLEQHQAPITAALTPAFSSDSTPEILASAIGACAVFVGCGVVKDVNRMGRILKLLTSALEQSKESGMLSLGDAAELSPNASVMLRIATLSAWAELEVASSLQSYLVNVIKPYRKTLASLWIASLRDYASIRADTEAFDDSSSGPLDSSYSSLGREVLLPYYLDAWPVILQAVATAMVADDPHILAAMDGQDSISTDTSQVPAHRDEPTAFFFVVFGLVYETLVASVPDSDIATQRTSIIALRALKCLVQNKYCGNVFNESPIFDELINLFYRMALTEPSGVQIYLVETLASLSQNLTSTQAETMTNGHMSREDLLSLPQVHCLRICAYVLRRAIKGPRNGVVHDGSTPMEKVALINAAFDTFSTIALTFGPVPKEQFRAVAITLYSELLRNETSEVDLVGPTLQSLKTLLEGPSNLAELEDNYERVVHGLLSACLVNVDEMRGRQGAISFRKIKSNLLASVLVLTVISPSVKVASAIIDHCCFLVSQRLIEADEMSLTAAHCTKTLIMASASGNAALRQCARLLLPGMIECLVKIAASSIEGTVSEQHLAILGEIYKAFSTLFLSIAEDIRPRALGILMPSIILLLDPARTTPSSMHSQSVNQLLSFAAASPSAFKEATGKLSPEMRDTLEASIRQVLGNKGPTTEAPKPQISLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYC8</accession>
    <name>A0A401GYC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multifunctional cytochrome P450 monooxygenase af510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1004820</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618148.1">
        <property type="nucleotide sequence ID" value="XM_027762347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYC8"/>
    <dbReference type="STRING" id="139825.A0A401GYC8"/>
    <dbReference type="GeneID" id="38784152"/>
    <dbReference type="InParanoid" id="A0A401GYC8"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE87235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="498" mass="56242" checksum="CAF381F131BF92E7" modified="2019-05-08" version="1">MYSIRIKNGRGLRLPPGPKPVPILGNVHELPSLHQERTFAAWGTQYGDLVFTRLFQTPALVLNSLQAAQDLLDKKSAKYSHRPRFILLEELMGWDVVTHMTYGERFRRQRKWMRDTLEDKSSLMSYRSLQKRESYILLSGLFETPESFMSHIKRFAAALIMEIAYGHTVRSLDDTYIQIADRATTETVEAGTPGSMLVDFFPWLRYIPAWMPGGKFKKDAARISVLVRRLLDTPYDMVKSAMAAGTAFPSFTSVLLEQTQNSGGTSPQDEADIKGAAGALYGAGSDTTIGVLATFILTMVLYPDVYKKAQDEMDRVIKKGNLPDFEDRESLPYLECVLSEVLRWNCPVPLGIPHKVMVDDEYRGYDIPGGTMVIPNIWSMTKDKENYPDPDAFRPERFEEMDGQTAEQRDPRKFVFGFGRRRCPGQKFADQSLWIAMANMIATLDIGKTVDVTGRNITPEASFDPGFVSHPTSFKCAIRPRSRKVVDLVNQMRAGMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYL3</accession>
    <name>A0A401GYL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1005040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618170.1">
        <property type="nucleotide sequence ID" value="XM_027762369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYL3"/>
    <dbReference type="STRING" id="139825.A0A401GYL3"/>
    <dbReference type="GeneID" id="38784174"/>
    <dbReference type="InParanoid" id="A0A401GYL3"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="72"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="215" mass="24016" checksum="E761B269E5E026CB" modified="2019-05-08" version="1">MSDSNIANTSSNAEAGSTWPGTSGSLVQENDKLDKRGIPAASGAVEAQLSSTLIDEDKELRCMICKAEKHGRKLIVALDETLNKFGSKVGLVATLLPSRTLTVEVQNSNIVEIYARMEKDSQQRSYYNDGIKYANTARSTIWKRTKLKLGSLFDTAFAWNFKKIVLGAYRWLADTYQPGDQIFMFGAFAVHTVPLSHYTDFLFQDFRAAHIRSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H000</accession>
    <name>A0A401H000_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1104330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618669.1">
        <property type="nucleotide sequence ID" value="XM_027762868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H000"/>
    <dbReference type="GeneID" id="38784673"/>
    <dbReference type="InParanoid" id="A0A401H000"/>
    <dbReference type="OrthoDB" id="2737573at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="201" mass="23450" checksum="0A7998C1A2BC0B92" modified="2019-05-08" version="1">MAIKDEPRELALPKNAVKPSRPQPKPGSGEKERQDALKQLRDYRRAAAWPVHRWPLEKCAALERTRIHLPRTYRARGGLEVRAVHSGADLNVLVHRFYLEEVRGGEKGRRDGDKERDVISRLDGVQLCERGPNYVTADDVVPRRHEYLGPDPRVVGYFFDGAGEVHVRFWDAFLRDQWMDTQTWQFDVRMDEHGKWAERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0E5</accession>
    <name>A0A401H0E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1201090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618797.1">
        <property type="nucleotide sequence ID" value="XM_027762996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0E5"/>
    <dbReference type="GeneID" id="38784801"/>
    <dbReference type="InParanoid" id="A0A401H0E5"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="784" mass="83569" checksum="10E4AE8C5ECBCBFA" modified="2019-05-08" version="1">MSSHDTTLLPSGTTIEYALSRPPVSASSVSSVEGDSEPAESKLAICLHPWSRLGGRMDDPILHILVGPLLERGYHVLRYNSRGVGRSSGWASLTGSREAQDLKEVVQWALSVVPAVVSLVVMGYSYGSLIASVLPVLPNVKTSHVLLSYPLGPRHWLTAFRGKAYTSALQALIQDPHSNVLILFGDDDEFTDSESYETWSKSLLEVSGANGVERRLKVVKIDAFKHLSQKMPLPDERPRQSVANLIGRFEEQNKRQSFTSPSASRPSSAVSFVVGDAAKEEIKEKREWPPKSRPVPSTVPVEPQNEEMKRKSQLPISPPEPAALLVREAAPFSSEDVIAAGPVPPPSVETAVPVPKTVPQRQSSIGAAPPARTPVTPSKSTPARSAAATRAPVRTPARSPPSSFQNTLSASTSTPITRSSSNTPAAAAKPRPSSTTPHRPPAPTTPARPKTPSVSRPKTPSASRPKTPSSVARPKTPASGLFAPTAASLAKARNASSPVPPTPTRKPTVGLATLERLSKPTASSISKVRTPTLPPPAAHARGGKVSGRGAAPTRGMAAKTRGGAAAKAPAKKAAALATVTASAADERAVESEVKEHPEEVPEHQHEESTSTLVDEPEHTAEFTEEPEVHHADGSDKEAIVQEVHAMGVEEANDRPEVTAPVDDYLDELSHTSESGPLEHITTESVTDEAVHETLSDTPHHDSDHDSVHVEVTSEVADLNEDEHVEGEVHDHNHEKGDIFFADDAHVNGKTGTDVEDIVNLLETKPRPASIAIIPDEVAEIPDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0I2</accession>
    <name>A0A401H0I2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1201500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618837.1">
        <property type="nucleotide sequence ID" value="XM_027763036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0I2"/>
    <dbReference type="STRING" id="139825.A0A401H0I2"/>
    <dbReference type="GeneID" id="38784841"/>
    <dbReference type="InParanoid" id="A0A401H0I2"/>
    <dbReference type="OrthoDB" id="3064354at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.50">
        <property type="entry name" value="Insect antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016133">
        <property type="entry name" value="Insect_cyst_antifreeze_prot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51156">
        <property type="entry name" value="Insect cysteine-rich antifreeze protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="3">
        <location>
            <begin position="28"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="592" mass="65467" checksum="FB7514D982D04E39" modified="2019-05-08" version="1">MPLGIILAEGPYPDCLHVEGVGSIALSPTGWTDRKLTLDWFKKVFVPHACAACDPAYPIVLTLDGHDSHETTLMKVVAYQNEIILFGFPSKMTNKTQPLDVAVFSSVQCQWYSHCQKCLAEGIKMSRYNVVKEYMTVRKVIMPSLVRMSFVKTDIYPFNPDVFSEEDYAPSRASSSTAHVPSSYPMDIPTSPIAASSDFESNDDYYPSSDKDEGDEDQSHVLPECTEDVECTKDVECMEDVECTEDVECVEDVECAEDVNCTEDVNCTEDVECTENVKCAENVECTEDVECAEDVECTEDVRDGDSLSPFNFPEAAPINSLFPEMTAYHTHSTSEMSIALSEAGRLVSVTRDEHLQKQEALTELRMLRYQNSMLMDAIAERDANLEAVNAHCTVLRREVQDVRTQLVNVMAKKMRGTTKIKARFITHPDLCDHFEVEQAMEEARNIENAAKAAQKAADEATLNKHIIKETNSRIFENSFASYCKHKSDLIILAGALNLSTDSTVADLTGRIKEHLDKNPQLAQDARFVGLFSSGRRRPNTAGSTMGTGPTTAVQSSGSTPGSSSSILASAWPPNTFGLGLAWTDPLPPPFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Q7</accession>
    <name>A0A401H0Q7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1202180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618905.1">
        <property type="nucleotide sequence ID" value="XM_027763104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Q7"/>
    <dbReference type="STRING" id="139825.A0A401H0Q7"/>
    <dbReference type="GeneID" id="38784909"/>
    <dbReference type="InParanoid" id="A0A401H0Q7"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="210"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="51524" checksum="2CE6BE317C863A44" modified="2019-05-08" version="1">MLGGVTLKKVSSRAFSQTAGTWAYTISETLAPKKLGESSKHQPRWSRHEHPVTNVLPAAHRKTSHLEPCRRSLCQSRVYSTSNTTGSPSDDKESIFSPMQSPWDHVFENIDDSPPVVPSVRGPQPLAKNTLSRAPRRQTMTAREITAFDEMFNMIFSAVEEQQHLKAADGHPRSLSAAIGRGRTPRLQLGDLFGQLRRQSRRQKWTTEADEELDRKKEEMELCDTDQQLLEWAMREVFGESRRYEENARRAMEDPAHAPAGLVQLQPQSYPHLLSLLMRTFRERYADPHLALSIFDHARHLSIPSFVFGCTTPAYNELIETRWRCFRDLRGVCDALEEMRVNGVEMDNRTRSLAEMIRREVGERNLWQEESTVGSGEVWDMVNRVERLTAKEVPKTHSRSRAQSIMKRKKFLPAYDTWKKKALQGNEPDDDWVFGEWDSPKTKVAPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1C5</accession>
    <name>A0A401H1C5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1300450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619144.1">
        <property type="nucleotide sequence ID" value="XM_027763343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1C5"/>
    <dbReference type="STRING" id="139825.A0A401H1C5"/>
    <dbReference type="GeneID" id="38785148"/>
    <dbReference type="InParanoid" id="A0A401H1C5"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF440">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="259"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="439" mass="50349" checksum="AE6BC24266A08D79" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGKDAKWPPKPTVEDAPDEEVSIFKEDGLPELITTETSPTSFGHSESIREIMADNTERGELPAVRNDTEPDDPSSEPPIDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAIDKPKTIEELVPNYLHDLKSIFEKKAAERFPETRPWDHAIDLKPDFIPHDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNHGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVQTRRVLQRLKDNDLFLKPEKCFFDVKEVEFLGMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1H5</accession>
    <name>A0A401H1H5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 16">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_1300570</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 16"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619155.1">
        <property type="nucleotide sequence ID" value="XM_027763354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1H5"/>
    <dbReference type="STRING" id="139825.A0A401H1H5"/>
    <dbReference type="GeneID" id="38785159"/>
    <dbReference type="InParanoid" id="A0A401H1H5"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15526">
        <property type="entry name" value="PHD1_MOZ_d4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000005">
        <property type="entry name" value="zinc finger protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="115"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="19">
        <location>
            <begin position="479"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="367"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="924"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1202"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="930"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="959"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1072"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1203"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE88242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1234" mass="136771" checksum="99CF03374E5AFC79" modified="2019-05-08" version="1">MSSLPYTDGFSFPHPESAERTTPFAGSDAIPIDPALNAPQFDPALMGMNGGVADVQSVRAHPSFHRFPFPPPRQYSQGPQGDPFAPQPSPAYYQVEEPPPPPLRPSKKKRQPRREEECGYCQGDDAKNKDGVPEMMVSCADCRRSGHPSCMDLSDIGEVMRSYDWKCAECKNCEVCHEKEGDNRMVFCDYCDRGWHMDCLDPALVETPPGRWHCPLCPPLMPPPVHASASAPEYQSPPYDEVDEVIDPQLRQASVASTSHIPDYDHPDHGHPTRQAPHEVIVVSESDDSDEDVVVEVDNDDPPTTKRSHKKSKSRWKGKGLMLNEPDEADATLSVPRAVKRMRLRLSSPVPPGSPAKAMPVIRLRLPPRGKGKAREEEPEEPKSGMFDEFLNPEDRDTTSTSITNGDKQRFERSRVTAEEKLFPRPTLPDIPETAGAGPSSRPLRSATQISVVPIARVTPEPSHSPSVSTPGPAPPKPPNGLRIQRIRFGDYDIETWYDAPFPEEYASIPDGRLWLCEFCLKYMKSRFGAGRHQMKCKMRHPPGDEIYRDGATSIFEVDGRKNKIYCQNLCLLSKMFLDHKSLFYDVEPFLFYVITEVDEVGAHFVGYFSKEKQSPKDYNVSCIMTLPVRQRQGWGNLLIDFSYLLSKKEGRAGSPEKPLSALGALGYRNYWTLSLMRYLRAAPPNPRLEDISAATSMTIEDIHSTLVHLNMIRVDVAATPMRPLPGQSIRFPKGRKNGIARKHLQRTQTQDDEKIKGPFVPPKEYMIHWDPEEVAQYLARWEAKNYLMLKPEKLKWSPLILTRTRRPEHLPANETESADVVETPVTATGAAEWDATPGLDAPLTPRPGKSVDPPSIMDATRSPALALFDDDNVVVVTPGTQNTPAKITEKPLARSPSVDPPHAMQLEQDRALALKMAKEQFASNRRLRSRDMSYDLPKLDTTKTGPEPSPSLRKGRSTRATTSNGTRINGQSSADHTMEDAASPARLARNGMRPMRELRSRSNATQDAKRPTSAPRSVSPRKRRRVESASEMETLPTPLPLRRSVRHAPENVDTPSRCTRSQHKPLRLANGSSPHSPGSCPPSASSLSSLSGPSEFPALEIEPLDNGEDVNMADNVDERQQEVPQEPTQMGDAVVDAPAEDDMKYEDVDTPFTAVTGQHSVPSDDTAVMMEESGAEANKLSPAGQPIDLLVSDAPEEALQVDGDDITQLDAGGDEDAEGEEDVDAEGEPDEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2A6</accession>
    <name>A0A401H2A6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1303390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619436.1">
        <property type="nucleotide sequence ID" value="XM_027763635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2A6"/>
    <dbReference type="STRING" id="139825.A0A401H2A6"/>
    <dbReference type="GeneID" id="38785440"/>
    <dbReference type="InParanoid" id="A0A401H2A6"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1054"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="4">
        <location>
            <begin position="460"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="861"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="927"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118772" checksum="BCD4CCBB7F4F55C8" modified="2019-05-08" version="1">MADRLPQQSSANFPGFNPQQSNGLQQLLQQLQVDPETANQSLSARTRISSHMLQQQMCLQAAQNNFPPPSIEQQPATNPFTNQRMSFGLPPHVPSSPSHVQARVMHQQSADISRGAAFPTTLQMQSLASRNPQMLQQMLHDQHAMQNHALQSQGNQQSELVGLAHNPQPQNGNPAAMAALRQMQQQAQQHQQSHQQSQQQQELYQQSQPQQQHQPIPDAARGPSAQQNLQQQSGALAPSPSGMPQQQHVPRCPFSFMELRTRMAALNNTIRELERQRLNTHNQNLTMPDAALEVEIGKINEELQRRRDLLEKLSTAMQQMTNAHSAALAANQSALRTSPVQSQQHPAATQNDQGHPQQGWPLQTGASQTPMFPFQQSAAQIMQSGPSQASKVPQMPPQGEQMNQFSPNSISMQFQPGAGQSSPNVMSTPFPGHVPAQATPPPPPPQQQQQHAPLRVQIPPLSAEIFSSAYKTFCTKNNVVHDPALMSHDGRPIDLYALHVEVMNAGFYNRVAQNDQWPVIGVELGFVQFPASNSEPAKSGPGVAQHLEHVYKQYLHAFDSTYLRSWLAKRSQQQQHDVQQAVEQARMHQKLIPVQGTVMSGRPPQVPHALLSQNGQDANGVPGLAGASDLQQLNEILQYATVPTPELQRQNVPARISDLVEANRLPLVRLLQRELRDGVAKNAQSTPQHHPMTSPDIAQIKQQGAVGNPAMAVRSGQYELQQNSSGSAGPAMTVASVIATVPFRHRTQPVTEEELLNNLRFINSVKSVLNMTPRPIPDDQKAQFNAAFEELCRCATETDSKLRLYLCYISQEAVRKLIAIIVYAQQQKKLLASSQCIMDIQQMRQMIILMQGTSEAYAQHTLSSASNTSPSHSAAPVPSPPPPFALPSSHTTIAPTQSSQQGLQSRPPPQFTSQQMSYPTQPPLQPPQHSQPAPSQQLSPSSQPIPPTPSSHLAATGGVAKNAQATPLQNPMPSPYMARITQLGRSSSDTKTTTMSAPPLHINLTIPENSPAHFLITVHDLTAATSVLSHPSDDPPYGIAVSFRPSSRRIFMNTTLKIVAVILAAFLGGILWLAVSSLDEMDLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2L5</accession>
    <name>A0A401H2L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619555.1">
        <property type="nucleotide sequence ID" value="XM_027763754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2L5"/>
    <dbReference type="GeneID" id="38785559"/>
    <dbReference type="InParanoid" id="A0A401H2L5"/>
    <dbReference type="OrthoDB" id="10347855at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="331" mass="36506" checksum="F3AE96B09C579B38" modified="2019-05-08" version="1">MENLESQAWHPGLSSDEPYNNTYQLHLQMMKKAYFDIKIDLDQNPKLHFEVVTATSNAGRLLWDWMDQFNSLIIAQAVTIRFLAALIAILRNSAMREGLVHWRHEDAHSIHDFGTPSWTSSPPAFEFSSPLPVVSTALDPRVLEGNQECDELQLSTTLKPPTLAHGILIHGEESVTLIDPWLCNDALASPPPLAFECSSPVSVASTALDPPMLQENNAWNRFQISSAPKSLAPKHPELTGEDESMQSIDLWQYDDFITLPGGQDAEPQQTVDSFACSMASNDGLYSGDPWVETGCDRGGLVLSGSEADALLPPLPEPMSITAFDDMEIFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3H3</accession>
    <name>A0A401H3H3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619890.1">
        <property type="nucleotide sequence ID" value="XM_027764089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3H3"/>
    <dbReference type="GeneID" id="38785894"/>
    <dbReference type="InParanoid" id="A0A401H3H3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="245" mass="27438" checksum="7543E47607365BAB" modified="2019-05-08" version="1">MPYSRHPSDSRAAQRRSLQQRNGESTKTRPLRILSPPPHLPRASSTRNTGGCCANSVIELIIPSGCLCTREAHLVDRGRLRPCMTAVVALTAQPDLDADFTTVHSASSRNRQPSTPPFHPVIYPHQHLPYVQEETLAPLGASSEGMEHRVKQAQLGLRHRQHRTPTPLDARAVHLTTVGSDTRAKHRDGRRRSPHLRCTHAATPWMGRTGNAHCRASLEGAEYRVKQAQLGHRHRLRCRRAHLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3I5</accession>
    <name>A0A401H3I5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1403820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619887.1">
        <property type="nucleotide sequence ID" value="XM_027764086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3I5"/>
    <dbReference type="GeneID" id="38785891"/>
    <dbReference type="InParanoid" id="A0A401H3I5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="65" mass="6789" checksum="3812E1C89EEB53E4" modified="2019-05-08" version="1">MSAGGESGSLGAISWLGLRDEERKDTPLLYLAEVEGPAVEGMENGDNARSDGTDVRTTQVGFAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4F5</accession>
    <name>A0A401H4F5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1503000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620205.1">
        <property type="nucleotide sequence ID" value="XM_027764404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4F5"/>
    <dbReference type="STRING" id="139825.A0A401H4F5"/>
    <dbReference type="GeneID" id="38786209"/>
    <dbReference type="InParanoid" id="A0A401H4F5"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE89292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="430" mass="47400" checksum="47FBCDD2F5DBEEAE" modified="2019-05-08" version="1">MCVNHRTDPAFVTRSYAALPGDNPPLLQSQGSCTKGTLNIIVEPGLLSIKPHSPVSPSCSDSSSSPTTPVDMHGLESCVAVADPAEDDCWNLIPYHIPWGPEYYNYKGGTLPGPDGKTCIFLRSPTPLKNRRTEKACNKCRERKAKCSGTQPACARCVSRGYICTYVSETKRSRGSTLSRQRRREKRVRAPSPHLSESWSTSSFSRFGSPTSSCSRPFSPKPKYEEVDDMALSPQLLYPDESEIDYWAVQAAENSLQWAQTTTASSVEDAPSQPVQVVDTRYDYTCDGYGTFAASVSVPADIVAPQPLATSSSRLSLYAPRPVKPFVPFLSPVADSILEHERGITAQLELQGMMHPDQIAYVDELSYGEPIAGYPIYEFSEDVHSSRDIVYLDPYSVAQQQYHMSMAAVYTQTVLEPHVSYSHYPISLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4H6</accession>
    <name>A0A401H4H6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cys-Gly metallodipeptidase dug1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1502580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620163.1">
        <property type="nucleotide sequence ID" value="XM_027764362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4H6"/>
    <dbReference type="FunCoup" id="A0A401H4H6">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4H6"/>
    <dbReference type="GeneID" id="38786167"/>
    <dbReference type="InParanoid" id="A0A401H4H6"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="213"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="480" mass="52176" checksum="48CBB2FB103591B6" modified="2019-05-08" version="1">MAALSRFLSFIDQNAGRFIQRLADAVSIQSISGNGVHRQDVFKMALWLQGQLDTLGVQTKSVDLGRHVMDGQDLPLPPAILGRIGDDPKKKTVLIYGHYDVQPAEKSDGWDTEPFTLVVDPATDRLIGRGSTDDKGPILGWLNVLEAHKALGLDLPVNLKFCFEGMEESGSDGLDELITSEVAKGKDGWFWGVDCVCISDNYWLNSRTPCITYGLRGLAYFKLTVSGPARDLHSGSFGRTVHEPMTDLVLLMSKLVDTNGKILVPGVDEMVSVASQEEKALYAQLDYSVADVENAVGAPIALSDDKVEVLMGRMRYPSLSLHGIEGAFYGAGAKTVIPASVSGKFSIRLVPPQTPEAVEPLVFAYINAEFARLNSKNKLKIENLHGGKPWVADHTHWNYEAAKRATEAVYKQTPNLTREGGSIPVTLTFAESLGVNVLLLPMGRGDDGAHSTNEKLDKSNFIEGSKLLGTYLYEVGAVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4Q9</accession>
    <name>A0A401H4Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620349.1">
        <property type="nucleotide sequence ID" value="XM_027764548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4Q9"/>
    <dbReference type="GeneID" id="38786353"/>
    <dbReference type="InParanoid" id="A0A401H4Q9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="56" mass="6420" checksum="F156901E03FE3B13" modified="2019-05-08" version="1">MKGQEYWQLKLTGASSQQQEQDHVGSEAEYKASHAKGYATGIMEAFCRRHIVGKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H526</accession>
    <name>A0A401H526_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1601120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620363.1">
        <property type="nucleotide sequence ID" value="XM_027764562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H526"/>
    <dbReference type="FunCoup" id="A0A401H526">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H526"/>
    <dbReference type="GeneID" id="38786367"/>
    <dbReference type="InParanoid" id="A0A401H526"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="17"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="136"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="236"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="325" mass="35648" checksum="247FE236831E0892" modified="2019-05-08" version="1">MADTPPQAVASASWLPAKSWQHFVAGGLGGMCGAIVTSPFDVVKTRLQSSLFREKHTTLGLAGNGVVVVPRRTNILWHFVETGHILKDIARDESPRALFRGLGPTLVGVIPARSINFFTYGNGKQIIAKQFNHGQENSWVHLSAAACAGIVTGTLTNPIWVVKTRLQLERHDSHTKLARPTSWGIIKKIMREEGVRGFYKGLSASYLGVTEGTIQWTLYERLKRLTANTEGKGGVLEWLGMLGSAGTAKCVASLITYPHEVVRTRLRQPLMDGKVKYTGLIQTFRVVIAEEGARSLYGGLSAHLMRVIPNAAVMYSIYEAVLRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H591</accession>
    <name>A0A401H591_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1602470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620497.1">
        <property type="nucleotide sequence ID" value="XM_027764696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H591"/>
    <dbReference type="STRING" id="139825.A0A401H591"/>
    <dbReference type="GeneID" id="38786501"/>
    <dbReference type="InParanoid" id="A0A401H591"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="824" mass="87867" checksum="3194E56485724E32" modified="2019-05-08" version="1">MQSSDLPTYASIVFEAPPPTYSASSTNVAPSTDAALPTNTVFSTDDAPTIRDTPPTTTASYTIPAPSATVAPSATNAPPTTTTRPTCVAPTAYRIGGVTLEAPRVELDHLRAHLALLRTFKSLRTLIEDAAELGLQGLRMGTTARWAWFVGLAVERFQRWAAVVRHESLFTWVATDLPPIDVLMVWHAYLLNPGWYAEDCVRLPIMETMRELGDRFVHAVAEMGDPEQYRASPERIASWQEQTDTPWDPLEAAIQMTHKTIECPSCRAFNEVPYLTTDGTGYAQHNFSYYCACGFEVTRATLAVRKFVGDLTKPYLDSRDPGWSYGGYMAGTLHTETRAKATRRAEVVKNAILRTEWFRKWDKSMPRNEWETGILQKLGYSFARARRIVGLALEPADSRLPTRIFSAYTDDLPFSIDLVGAVVRQGAFIDKMHEFGWTRPGYFDDEEDELVLVHATARYHAFLDLMSSSPSSFFVPTLDIDLVWHSHQLMGSRYAGDCIQYVKRYVDHDDKVEENHLATSFDMTSRAWQERFHLPYTHCGCPLPGESIGRRLSRLSLGLFHKHGPDLSLELLPPAREDALSATHPSEHNSVESGRSIFLKWQRRQRMDKLARRRKRDTERAVAGRMDADVYQRGRTHDAAFLVPVPFYSPVAACVVVVNPLGPLPGAAPTDVNLCAVGAGACRVADASIDALKWSNARCVGGGSGGSGGGGGSGRQGGRTGIGRSGGVGIGGFPGPGVVGGVGFATGAMIGGPAWTGSACGAGFPASCGCGSGGSVGGGGGSAGGAGCGGGGRSGSGCGGGGGGGGGSGGVASCGGGGGVGPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6N3</accession>
    <name>A0A401H6N3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1801190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621008.1">
        <property type="nucleotide sequence ID" value="XM_027765207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6N3"/>
    <dbReference type="STRING" id="139825.A0A401H6N3"/>
    <dbReference type="GeneID" id="38787012"/>
    <dbReference type="InParanoid" id="A0A401H6N3"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="2">
        <location>
            <begin position="125"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="898" mass="102995" checksum="D613A1DCB358351B" modified="2019-05-08" version="1">MRLSVRLSKALRQGLRAGTVSLAFLRDNAHTIAQMDYMVLEDSGHNLENIQFWKNFRLMEIQGKYDAHERDTSRRYLSILPVFKRMTQTTLEYFTIGQDRLMSLTDNWGTDYPSPLHLNEMTGDDLQNIAFLFGGVGDARHVYATLIGLHRASKTLSKTKRKKLRAHFTLLDFQPSALARDLCIMMLLEYLVDHVDVQMTTLLEVCATIFYTYVGVVMPQYCHDRLQITIQNLLRRLSEQPPRLPFWIHVDPASIPRLLEALRFWSTVHEGLQTKRVLRTHTPESPDSPLIQEYQPNFGEVFSSERQLLVENLRRLDPSQLEEHDVFHPGPNATPLQKWIFEARLDSCARTVLEEEPPMALERRWYAGTKVFLPPPELWSRHPGFEYFRSMRTSRTSLPLAQAESLRDEIALSWKANPTLLNSRNDGRQPYCLPNPFETPHFIEDFNVETGLKPRSSYGTNSDAPAFTAVADFFRATAEAVRGMKDRVVLEVLCGELSQEIAKMQLDNNASRPARFPKSRPARFPKSRPARFPKSRPARFPKSRPARFPKLFTRAYVSNIPDYAHGLINTIVYNLPILRSRAESAIAATSFLNRPIWSSNEEFCYTYTLLLPKDLPRYLGCRVICADLMGKIILGKDPLPKPVDKLVIREELFSWPTRTLLYIIIPASSDEQATNVVRLPHKLVAFFGLLVHLQHVGYPSHWFTDFVQTMLYNNVATDIAPYLGSAPIPVSDISRRVPMRKIRLDPWFAEFENILALTYKGLPFAVSLPDSFAQSHTDIGLFESASSPLFPVALDRIPSVCLLFYKPGAGMDPAELVSAVPSILEGQSLPRQDDLYILTALQSLQCINHVWKAQWMFSWKRIQRLRREKWLMVVYHAALRRPITEPEPASRWTEVSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5H2</accession>
    <name>A0A401G5H2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0102820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608322.1">
        <property type="nucleotide sequence ID" value="XM_027752521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5H2"/>
    <dbReference type="STRING" id="139825.A0A401G5H2"/>
    <dbReference type="GeneID" id="38774326"/>
    <dbReference type="InParanoid" id="A0A401G5H2"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="243"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="243"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="383" mass="42655" checksum="DEFE5B7C30CCDFCB" modified="2019-05-08" version="1">MSRHSPLHQEDASMDSQISPYSHHVSSSPLTFPTRQVEPSIKYGGNDTSTHIINGVYGTDWSYDTVARYQAIQSGGHNDNARAGGTAFALRREHNYLDHIPSAGGVEDSYSRYIEWPYHPTGECLLHKAVCSSTSGDGEAGSLSPVPYPANMPQVPGSPNICHPTIHLPPPVPVHTQLASKTAAHSPARLPHPRDGPLLTPSVAVAGQINPVDSLEVLRADVGLTPDQPLSLLSLPDRTDDCKPEYSYHILIKLAILGSLRQRLSLQEIYKALRERFKWYKEHKDDKMWQGSIRHQLSLRDCFVAVRKPLRDPGHGFEWIVDYSRGDGIRRGRKRKSRGEDPYPPPLVTGSCPIQNHVSSIQIQDLQTDPTLRNTHGNKRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5V1</accession>
    <name>A0A401G5V1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0104190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608455.1">
        <property type="nucleotide sequence ID" value="XM_027752654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5V1"/>
    <dbReference type="STRING" id="139825.A0A401G5V1"/>
    <dbReference type="GeneID" id="38774459"/>
    <dbReference type="InParanoid" id="A0A401G5V1"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="922"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="970" mass="105828" checksum="1244322E6B954764" modified="2019-05-08" version="1">MSHTHHIDNEDPLFQFDSYDQLISPVNHLEVSARPQLSSLNGVDLTGKPSSSNFISKTSQPRPPLSSGKMEDTDVKGKGVPQPVFVAASGVLEDDCAPDAEDDMFAMSLGSASSSVQTPVLDVDEETDEDIGDSLGKGKARELPPSLPPLSLYTELNYESSDWPSFEASSPAAAGPSSYRSISASINTSERGHNVSVVDRVSAPPEFSGQVLGVVRVPSRRRSLSSLSVRSNRSLSTLSMSKVKVRLAGTKGPGNLARKLLFKKRTSPPESPSSADSTSDIDVSGCEEASCFSPWSRDLKGRTTAAPMLDLDLSLSGLDPLLPLYCAGRGSNECNMLRTKGRSYSSPLPLPSTPLDLVPVTTADIFEPIRVVSRNYFDEYLPHELKVQVLAALVHLHEAEYQRNVREGEWTVLKASSSRNKWVGTAKGLRELFRLSRVSKYWQALVYDGQLWTNLDLRYFPKLPASVLAQLCDVAGGFIRHIDVTGHVSLSHTTLLDITNFLCIQTSITGDLTHTHLTSINLQGCSALSTRSLHNLLIRSPSLQKLCVKGLTAVTNTTCDILAVYCPKLVTLDFSRCPNMDGDGVHCLASTRLARKEHLPLKVLRLSGLKRVTDDMMACLGKAAPDLEVLDLSYARDLHNSAVEAFVACTEADAVDGTAVQLTSREAGRDPSDPTSYWRRVTCLRHLALSSCIFLTDHACSHLAHAVPKLEFLEMAGIGADLRDDGLVRLLGTTPFIRRLDLEDATEITDDLLFAITPDLATASAPSSRTPVAPQPGHALEYLVISGANNITNDAMQELICSCSRLRVLEADNTRVSGLTVREFVETMRERKMVNAQVVAIDCRNVGEIAVKDLIPHTRPRIGWRAWEAKKLGYLDARDEEGLNVGQDECDKYRVALKTFYSWQTVDAVRAARDKKRKSKRSVNVSSSGAGESPGPSSRAKWWSPGGRRSGATSPLVMDMNNDREGCVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5W1</accession>
    <name>A0A401G5W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="18">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0104290</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608465.1">
        <property type="nucleotide sequence ID" value="XM_027752664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5W1"/>
    <dbReference type="FunCoup" id="A0A401G5W1">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5W1"/>
    <dbReference type="GeneID" id="38774469"/>
    <dbReference type="InParanoid" id="A0A401G5W1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="475"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="859"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="951"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE77552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1119" mass="125179" checksum="544E7976A9A0AE85" modified="2019-05-08" version="1">MSTLFAGSDDEDDPVINTSEHQSYGYVHSSTQKPLFFADSDSDDNEDIVAPTTDPARIIQAETFADEMMDLDSDIKIPDIDEVPRASSVPSSASSTHDLRPTSPASSVHYEERPAKKQRFSPPPDEGTANVFTSAYVGSFLVGNAWSTVRGTGYVKPGDEICVDRDTQEELKPPIVKLSSSKDAKGKRGKRQLSIATMLKPQAKPTKKKENLVVRLTNKSGFEFGRLPQEVASWVSKLLDLDIVDFRGSTIIDCPAKLHSGADLIVSLSVHMKATAFKAPSTFSDERPKVMFNEGQETATEQMLRERKSALLKLFKVVSLKPTRGSSFTRKSRGELEKKDLEVLTQQPQIDKGKKPVRTEIVGDGEEVEVEGEGDDISDNELDLIYKRAQQNDQKLGEMDPADTFSLSLRGYQKQALLWMYSIETGIASAREARSMHPLWKEYTFPPEPGKNMIDLTDEKAFYFNEYSGELSLEFPKAERKCRGGILADVGMGKTIMLSALIQTARGPEAPSVDANRSCTKNRQLKLNSAFRSVSKHHGRESRGPSATLIVAPTSLLSQWAEELQRSSQPGTLKALVWHSQNRADLDSLLDDDNAVDVVITSYGTLVSEHAKGERSSSGQISPVFETEWLRVVLDEAHHCKSRQSKTAKAVYALRARRRWAVTGTPIVNRLEDLYSLLKFLDFTPWSDYTFFRSFITLPFLARDPKAVEVVQIILESVLLRREKDMLDTDGKRIVDLPGKEVIFESLEFSPLERKIYDSLYSDAKKDFDQLNARGLVSRNYTHILAMLMRLRRAVLHPNLVLSDKKTDEKPDADRKGDGVVDVNTLIKRFGEGDNTVGDSKVFAEDVLANLGQDGGTECPICFDVMDAPTIIPSCMHQCCKDCIVAFIETCRDKGEDGRCPTCSRGPLKESDLLEVVRTPHESTDNAKAEVPEPVVTLRRNDFRSSTKLEALMQNLRRLRDQDPSFRAVVFSQFTSFLDLIQVVLERERLAWFRFDGSMDVKKRSEAVSGFKSPSRDGKVLIISLKAGGVGLNLTNANHVFMMDCWWNAATENQAIDRVHRIGQEKTVYVKHFIISETIEGRILQIQKRKTAIVKEAFRGKGNADPESIENLKIMFGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6D2</accession>
    <name>A0A401G6D2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">SCP_0106070</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608638.1">
        <property type="nucleotide sequence ID" value="XM_027752837.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6D2"/>
    <dbReference type="GeneID" id="38774642"/>
    <dbReference type="InParanoid" id="A0A401G6D2"/>
    <dbReference type="OrthoDB" id="3344688at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="535"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="800"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="880"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="GBE77725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="30">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1448" mass="163703" checksum="3C8468912168996B" modified="2019-05-08" version="1">MSTSADNTSNSNAYRIPLLKEDNWLPWKRRVEAILNDKGLQEYVTGKTPKPQPSNDPANRAAREAEISAWGEKDLKAQNVIVLSLGDSQMVHIAGAETARAMWEQLRTVKEQRGQHGILALCRRFYRMQAKEEDNISSHITQLRQIQEQLHLMGKVVSDEDFRLILATSLPESWDSFLSSYFGAVGGNVGAEGADNVRPQLTSQELIAIIFDENRRRHERGERGQSSDQAMVAKGKKRPFGEYKKCSICGKPGHLGNECRHRDKVKCMNCGKFGHKATDCWAKGGGKAGQGPPMKRQKMERAYEAREVESKEDEAKIAYDNDSDTVSLGSDGEIASFYEWFADSGTTSHITNRCEVFATYQALEDHTIMGIGPQPTQALGRGTVDVESEVGDRKVKFRLHGVLYAPTAPNSLLSIMRLDDTGGRVLMGNSRAILIDKNKHTLAIGKKNGRLYSLKLRPIVPQPVRTYTAKEYGPHTWEEWHKIYDHIGKPALMRLYREGLVDGLEISPSPDEINCEACIQAKATRKPFPKETDECNKVPGELTHTDVWGPAQTAALQGWKYFITFTDDYSRRSTVLFMRHKDEVTEKVKNYITYIEHKFGNKPLRLRLDNGREYMNTELINWCQMKGIEMGPTVPYSPSQNGVSERLNRTLLGLARAMIYARDLPRYLWAEAIAHAVYIKNRSPTQALNGATPEEKWNGTKPNISYLQEFGSPVWVLTEDATLSKLAPRANKYIFVGYMDGPKAIKYYDAHMRQIKISRNFQFSSNSPDHLPGNAPHVPQEQIGSDIPILTAQREGEQNIFPGTLSSNASDVPHAERRPEVPNLTTTADVQREGELGTSTPQSPAKNPRKRRQDDDPDQREESGTDAPSQPRQTRRKTVRHDYRLMHDPEADEDLDNDPDKSNAELVYIAMSAHGNVDADEPKTLSDAKRSLEWPKWEQAVQTELNQLQGMETWELVEPPEDRKPVGNKWVLVKKTNKEGEIIKYKARLVAKGYSQIPGMDYTETFAPVVRLETIRAILGLAAILDWEIGQMDVKGAYLNGTLKEEVYMRQPEGYSDGTYRVCKLKKTLYGLKQSGREWNIVLNRKLLDAGFKHLFSDPCAYIRIKGDKIEIVTVWVDDLLIFTNGCALMDQLKRELRNMFEVTDLGEPRKIVGIEIERDRSKRTIKISQTKYIESILHKNGLTNANTVGMPLDPNTVLEKEEPETDDECDRDNGYASLVGSLMYVAIAMRPDIAHAVQRLSSFTANPRMAHWTAAKRVLRYLSGTRELGIIYGPIADVKPEDQSIFVGYSDADYANDIRDRKSISGYLFKLGNGTITWSSKKQTTVASSTTEAEYMASAEAAKEAVWLRTLFKEIGFEQQDPTILFEDNTAAISIARDPQFHTKSKHFDVKHYYVCKKLRDKYIDIHYCPTEDMIADILTKSLPKPRHEKLTKKLRMPIGLRGSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Z1</accession>
    <name>A0A401G6Z1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0108230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608854.1">
        <property type="nucleotide sequence ID" value="XM_027753053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6Z1"/>
    <dbReference type="STRING" id="139825.A0A401G6Z1"/>
    <dbReference type="GeneID" id="38774858"/>
    <dbReference type="InParanoid" id="A0A401G6Z1"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="1">
        <location>
            <begin position="70"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="433" mass="48192" checksum="677F05D793538C6F" modified="2019-05-08" version="1">MSSTPSSAGPSAPPPVCLVRDEYSAADAARLRLAPPRIIPSISMPNLRRAQSNTTEHRRRAKSREFDLSSLTLNEIPTEFSESGFHAVVIDDEAVSSLSLSDDKDVYRWAVLYENQRGAFVFSTAYYSPMSLLPLDPPPFTIPTTSGSMRKDQPTVSLTDYPLPDGTWRWVSREWMIDMRGDGQVQYDGFEYAWSFRSKKWRPTVGILSSGGWVRRRRWVRLMVRPAKSLRTGVENAGHPINQSDLLQLAHIEAGATRPPSVATSLTEDAQTAGDVVWRGDEDDWVRCHAALKALGRDGRRLELWQRWLGLPVLPVLPSIELDASSEGSGKEQAKQLQSNEDDSLIQPIEVSDDAFIDEIANGVGASPEVAPLDYLAKVLRAHGADILKSFVYPDSRARWLTILEKAGVVEEVYCGLSVSDSRMTLDFWSYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G773</accession>
    <name>A0A401G773_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UROD/MetE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0109020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608933.1">
        <property type="nucleotide sequence ID" value="XM_027753132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G773"/>
    <dbReference type="STRING" id="139825.A0A401G773"/>
    <dbReference type="GeneID" id="38774937"/>
    <dbReference type="InParanoid" id="A0A401G773"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005085">
        <property type="entry name" value="PRK06520.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="69"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="451" mass="51190" checksum="9547541AFFC9214F" modified="2019-05-08" version="1">MTLAWTSKKLHLLLKHRTPRLLGLFHVSKLSISMNHAWRRHLTCPGITHIDPVLTMSTRLNPPFRAEHIGSLLRPAKLVAKRFEFETGACSAEELKAVEDESIPAIVKLQREAGMKTITDGEMRRAAFYQGMFEKLGGMEIVPNCSLTTFKSYIPYVGIFHAMGLTEYSSIYCNGKIKRTEGVHTDDFKYLKSLVSSEVEHIKVTICGPTWMHLRHGSDHTYDKSVYTNDAQYFADLIQAYREEIKELYSLGCRNVQFDDPTFCFFCSDSMITGMEQAGVDHEALLRMYIDVFNDITKSRPADLTMGVHMCRGNFKGMHYTAGGYARISETLFKRMDVDCFYLEFDDDRSGDLMPLRYLPPNKTAVLGLITTKRGTLESIANLRVRVEEAAEIISQGDPKRPKSDAMNQLCLSPQCGFASVFEGNPISEEEERKKLELVVEAAKQIWQSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G792</accession>
    <name>A0A401G792_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NADPH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0109090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608940.1">
        <property type="nucleotide sequence ID" value="XM_027753139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G792"/>
    <dbReference type="STRING" id="139825.A0A401G792"/>
    <dbReference type="GeneID" id="38774944"/>
    <dbReference type="InParanoid" id="A0A401G792"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="241"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="564" mass="64692" checksum="17B25B6D7A18201B" modified="2019-05-08" version="1">MGRIAVVEGWFRREFLSPRRAIFNFLFYGIQFTLFGVGWYLQATDNKLAALNGLKFSVWISRGAGLVLAFCGGMLLVPMLRNIIRVVRPKLAWLFPADENIWFHRQVAYCMAFWSMVHTSAHYVNFFNVERTQVRQEIALDIHYTQAGGITGHFMLLIMLLIYTTAHHKVRHQCFEAFWYTHHLAFFFFIGLYSHATGCFVRDTTDPAYTDTFPFYNPEFCLGYESWRVTIWPGIIYFAERMWREIRARRTTRLSKVLVHPSGAMELRIVKPSFKYVAGQWLFIQVPDVSSWQWHPFTITSAPEDPYVSVHIRQVGDWTNALGERVGAGPEVVAMMTRTAMKGSEKDDSVYGTRGDYVELDSSAMSRPLPTVRIDGPYGAPAEDVFSNEVVVLIGAGIGVTPFASILKHIWHRQKKGTLQSLRRVEFFWICRDAPSFGWFQILLQEVEAAQVDPNFLRINIYLTQKINEDMLWNIAVNDAGADYDPLTLLRTRTMFGRPDWKSVYGRMRQAIEIGQYLPGSQSQLKTKVGTYYCGPGVIATAIKEACKANSTPNITFNFAKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7C0</accession>
    <name>A0A401G7C0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0109470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608978.1">
        <property type="nucleotide sequence ID" value="XM_027753177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7C0"/>
    <dbReference type="GeneID" id="38774982"/>
    <dbReference type="InParanoid" id="A0A401G7C0"/>
    <dbReference type="OrthoDB" id="2757503at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="308" mass="33858" checksum="771DC45FCB715950" modified="2019-05-08" version="1">MRHTSVFDRALARAQVLYSPFLIIPCLMAPLAPRHSSQYSRARYGPPALRIFTQGQSPQPRMADIAIERFKQCLNIRHDNDEQLDSSRKLHPHFCLSTWDRQLACHEALTDIEDAAVGAARLADIAFIGIGIRPEWLSKEPLTADTVKIDVILTCQFEQYPQWKTAIDKIQHIVQEEIGVPHILGYSSRLDEVTPGPEYALDLETRRICSNPIRLATKPASSQPRTSSSARPLTSATVAASSSQHRSAPSSKEQSGSLGVKAMTSQIAAAAGISLSQGSAPLERTAELLSHASQPLLVHHRTAITLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7C9</accession>
    <name>A0A401G7C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0109570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608988.1">
        <property type="nucleotide sequence ID" value="XM_027753187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7C9"/>
    <dbReference type="STRING" id="139825.A0A401G7C9"/>
    <dbReference type="GeneID" id="38774992"/>
    <dbReference type="InParanoid" id="A0A401G7C9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="10989" checksum="EBF49F94020FBA1A" modified="2019-05-08" version="1">MAVGPSLRTLPMAVSRWLYNSPSGDGPITQNTTYGGGPIAQNTTYAVGRWLYNSPSGGGPITQKYTYGGGPIAQNTTYGGGPIAQNTTYGGGPIAQNTTYGGRPMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7D9</accession>
    <name>A0A401G7D9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0109640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608995.1">
        <property type="nucleotide sequence ID" value="XM_027753194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7D9"/>
    <dbReference type="FunCoup" id="A0A401G7D9">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7D9"/>
    <dbReference type="GeneID" id="38774999"/>
    <dbReference type="InParanoid" id="A0A401G7D9"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="40"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="343" mass="40217" checksum="8FF7352FFA9633A2" modified="2019-05-08" version="1">MGRTAVKSVARVYADVNAKLGPSWHEYDNLQVQWGSQDHYEIVRKVGRGKYSEVFEGVNIVNEEKCIIKVLKPVKKKKIKREIKILQNLAGGPNVVALLDVVRDPSSKIPSLITEYVHNVDFKVLYPRFLDFDVRFYMLELLKALDFCHSKGIMHRDVKPHNVMIDHDRRKLRLIDWGLAEFYHPKTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSYGCMFASMIFRKEPFFHGHDNYDQLVKITKVLGTEGLYHYVEKYDIALDPQYDDILGSYPKKPWSRFITSENQRYISNEAIDFLDKLLRYDHQERLTAREAQMHPYFDPVRNAALRDGDSEGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7N9</accession>
    <name>A0A401G7N9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0110520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609082.1">
        <property type="nucleotide sequence ID" value="XM_027753281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7N9"/>
    <dbReference type="STRING" id="139825.A0A401G7N9"/>
    <dbReference type="GeneID" id="38775086"/>
    <dbReference type="InParanoid" id="A0A401G7N9"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="247" mass="27860" checksum="18C9C6E2651AC7A2" modified="2019-05-08" version="1">MLSAGNEFKEVVCRPLRYDEISKAVDVTEEAFRDNPLVDYLHNTPDARDSRLVRIGRKAASMIQSSHYVRSKEMLGINGGDGSVMYRSPLTLLSQPRRVLERTLRVILMAILSVCFRLINSREQWQRFQETRKKGDAAAKDSIGDQIEDMFAIDLLAVAPEKQRIGYGSALVGAVTAKADAHSKGTWLITRPPTAGFYERLSFTVVGEYTLGESNPTWTKPPVEMVVMVREPKLLDMYSNLEKGFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G869</accession>
    <name>A0A401G869_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AC transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0112230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609251.1">
        <property type="nucleotide sequence ID" value="XM_027753450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G869"/>
    <dbReference type="GeneID" id="38775255"/>
    <dbReference type="InParanoid" id="A0A401G869"/>
    <dbReference type="OrthoDB" id="2802474at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33140" checksum="03181CF4FDB1550A" modified="2019-05-08" version="1">MINIAVLATNGVNILNHKRTCKEIIETFKRQLTELWDKLNSDAVDGKINLICDVWQASNTDSYFAVMRSWVEETKAGVWSIQTALLGFTQLNNAHNGKRLGQALYKIALRVGITHKVLFDPKRHCICCLTHVINLATQAAISAYSNSKHYDPEQLDNDLMAQHGAEHDEVGLVQSICVKYVDAFVRKMARKEKDRAKRQKLDDLQLSTDKWDCVHLFLNLLTHADNAQQAFLSDSGPALHLALPALEALHKAWSNRVEQEKYTPFAKALKAGIAKIITSGYPSDLALSFNIIYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8U6</accession>
    <name>A0A401G8U6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0114830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609507.1">
        <property type="nucleotide sequence ID" value="XM_027753706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8U6"/>
    <dbReference type="STRING" id="139825.A0A401G8U6"/>
    <dbReference type="GeneID" id="38775511"/>
    <dbReference type="InParanoid" id="A0A401G8U6"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="258" mass="29704" checksum="84953CA8C71C44F2" modified="2019-05-08" version="1">MPMLAWMWKHRTPTWSATRRGQHASAIPNKHLPLTLAMTLILLRRAFTLLDSETWVSGIRSASTSSLKSKSTKRQSSSPPNNAPQPSKQPAECTELDAFFAKYPTFDYDPSAPVTVELRRMCKFFQWPKKKRREPKLDKHEERLAAEEGFRKALVGQFNSLFGKKVDKLQNWQRLCQLLQIDPIPIGLEACRKAVKNTHVNLIDLVDYTRTGTPARIHPSEERLRDYTKAEGKYFPKERAHAGGVLRYLLRRIHVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G930</accession>
    <name>A0A401G930_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0115620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609584.1">
        <property type="nucleotide sequence ID" value="XM_027753783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G930"/>
    <dbReference type="GeneID" id="38775588"/>
    <dbReference type="InParanoid" id="A0A401G930"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="71" mass="7457" checksum="14FDD9992925CC61" modified="2019-05-08" version="1">MLSPTGTSPPAIADDPRLPMTQSIDSGRSGRSIPPGVEYTVGYSRSRRHARGAPSPPSSGTTPTPFSPYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9H3</accession>
    <name>A0A401G9H3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609720.1">
        <property type="nucleotide sequence ID" value="XM_027753919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9H3"/>
    <dbReference type="GeneID" id="38775724"/>
    <dbReference type="InParanoid" id="A0A401G9H3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="171" mass="17398" checksum="86E2F59F57571311" modified="2019-05-08" version="1">MSSSTTTTTTFFRSSGLASNACSHPHARLHRPSPSSQTQFGLQPSSHRKDQSAQNAGPSGSVHYAPGGAHAPRGQPGSAAAAVGDARSLSAVVSASQPCKIGCPVGRSHAPAHVPSNGNSGPPIGRATISPRARRGLVARAAGRRGWTASPPRRSAPGSARAWWSQSAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9W0</accession>
    <name>A0A401G9W0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0201450</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609861.1">
        <property type="nucleotide sequence ID" value="XM_027754060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9W0"/>
    <dbReference type="GeneID" id="38775865"/>
    <dbReference type="InParanoid" id="A0A401G9W0"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018971305" description="Protein BIG1" evidence="11">
        <location>
            <begin position="16"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="279" mass="29897" checksum="A6FB4B31633C17E1" modified="2019-05-08" version="1">MHLISLALLPVAALAFSDTHPLLIWSSVSSPSLAFDSSKGSDFAKNLLKAPDICSHDAVVFINQVDLHAADLHTLSPSSGLVNTLESAFASFQFPYVRRTGGVNPFEKLADELALRCGARLIHTSIDEDDMPMPAHGDAKEKHVVCMGMPSLEGVHGATRKSMMAKHESQLSSALATLARTHPHYLVLYSGWSRSNLARQSSSPNPFDSSNSTAANALPSGGILARYQLLTPALLLALILTLGVLVPLVLFGVYALAGVQSPVRNDPPKQWISAEKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9X5</accession>
    <name>A0A401G9X5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0201300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609846.1">
        <property type="nucleotide sequence ID" value="XM_027754045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9X5"/>
    <dbReference type="GeneID" id="38775850"/>
    <dbReference type="InParanoid" id="A0A401G9X5"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="221"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="391" mass="44343" checksum="6F799FACA971746B" modified="2019-05-08" version="1">MFDNCAFWLWAFANMIITTGFAWSGVTVHKLRFDLLQNWIATGFNYSRRRGSLSLYPGGLCAQNTPDDGSATDSIYPYYNRVCHRSIMLQALDVSPTSVDKSSLAKPQKFWINGAEPIHSGDCEQADKDSIGKPAPVIDEACTIAAPTTSVGGVKLAMEKTMMQDFRKARRRRVPRLLVPRKLICIDQLEGEEFISAWLDCCRDHFQRWSKGVQLGHVYLQNLVYDSASKRGLFIDLDVCVDVTHSPESPSPNGIGTHNFRALDLFYRNRGMARMGTRHYHHHLESFIWMLPFVLLQGSEDHNQIAMLNEWKSTVVIECLSERQYFLLHCDLTRYKTKPANEGAWKKACAVLLWLRKYHGEEGWLASSTKQADILLGEVEGLVTTGPYDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Z3</accession>
    <name>A0A401G9Z3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0201820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609898.1">
        <property type="nucleotide sequence ID" value="XM_027754097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Z3"/>
    <dbReference type="STRING" id="139825.A0A401G9Z3"/>
    <dbReference type="GeneID" id="38775902"/>
    <dbReference type="InParanoid" id="A0A401G9Z3"/>
    <dbReference type="OrthoDB" id="74813at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="60944" checksum="A900039DC3E4AD5A" modified="2019-05-08" version="1">MRVKIESVAPLPTVKAWYSVHSVSSVSEMKARLCSELQPFHGRVRAQDIVLVLEDFELLDSSPIDVVRDGDLIVVRHVPAVSFHKRKASTDEAGPVRKRSKHPSDTTPLPPVLRAASRKLQLNVSTKRAAIHADASLTSDSESTSSSESESESESKPKSDSSSSDSDSNSSDGSSSSSSASARAGMLAVTKAKVGTPAERSAPATHKSNQRTETRHVPPGEGKPGTHNRNIRRRRKRMYERLAATAEPASVNAIPLGSKVHSLVPSQRETTNLPRTEEEQSVTPSNEANAAPAFMMASLQNKNKRRGFKNALAFGVPAKIVFSSPEEVSADTARIEVGAAQDVLPFSRAQGNEVADAIRSTSFVRLVPPSEKEERGQLPPNMFITSVDVEEGLPAKKRKKQSKVKAWEKDATAEDSYLPYDEPDEALGADTMGASAGCNSVTESQLSPSFDRGIVEGRWSSLTKITAPAQLQVGCKVAWKALGINPNTFTPEMLLNVGRVVSYEDQLVVKPLEEHGAVEVSFGGLVVGEDSGSVEERYDWQDVLQADWRLVAYRVKTREAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA00</accession>
    <name>A0A401GA00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0202010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609917.1">
        <property type="nucleotide sequence ID" value="XM_027754116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA00"/>
    <dbReference type="STRING" id="139825.A0A401GA00"/>
    <dbReference type="GeneID" id="38775921"/>
    <dbReference type="InParanoid" id="A0A401GA00"/>
    <dbReference type="OrthoDB" id="2755157at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="207"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="424" mass="46789" checksum="134FBF1EE6238218" modified="2019-05-08" version="1">MASPAALIESTLGYQFIGFAMATSCYGITMIQGYIYYCNYKEDRPGLKAFVYFICALDTLCSALVSHALYVVLIMDWGNVIALERFPWSFALENGVTVFITFLVQWSVWSYGTLAMQSTSSLVQLLRCEITVVFVFNVPRDAAPNETLSFAVRKKLALASAAVAFTGLVAFGAGIALTCQLFITKFYDKAVQGRFFLIACGLDQGAAALCDIIVTVSFTWGLLSERMHGAKQTRSVIERLISYTVTRGILTTIIQVLMVVVFCSLPTKDVWMLAHLILSKVYINTMLAILNGRRDLREVIDKTVVLRTIDFRHGNTSVNTSAAIDESFSRADSNNLPASPEYARYASKFPSTSAPLEFLLAPPGPKRTEVLLISPRSSYIRSLILAQAMEEQAVRITALYSTVLEDPRSRGLTEVVLHAQNFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA36</accession>
    <name>A0A401GA36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0202250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609941.1">
        <property type="nucleotide sequence ID" value="XM_027754140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA36"/>
    <dbReference type="GeneID" id="38775945"/>
    <dbReference type="InParanoid" id="A0A401GA36"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="148" mass="16165" checksum="0BFCB4B0EF1E5455" modified="2019-05-08" version="1">MHTLPGLVLNEFDSLGIFIVDKGHMMRTGCNIYAAVQLLSRLAHLKLDLIYVGHAIGIAGCLGVHVDEFEKELIHNLDRARCLEAAELGPHEVVASDLDVATACTHEAHIEGIKCIKEMYDDCIIRHMHASKNEHGESLLGLAGDSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAB9</accession>
    <name>A0A401GAB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0202980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610014.1">
        <property type="nucleotide sequence ID" value="XM_027754213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAB9"/>
    <dbReference type="STRING" id="139825.A0A401GAB9"/>
    <dbReference type="GeneID" id="38776018"/>
    <dbReference type="InParanoid" id="A0A401GAB9"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="106" mass="12162" checksum="1355590EDD970B4F" modified="2019-05-08" version="1">MDNRINVKTRAFKCYCIPVMAYYENDRTVPDNHLCRPDLPAGCPHCAVIKSSICCEICSPDSPHFKVVPYNSEKPAELMSTHASHIPREYVMVPTDIKFWKALNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAQ8</accession>
    <name>A0A401GAQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Negative cofactor 2 complex subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0204420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610158.1">
        <property type="nucleotide sequence ID" value="XM_027754357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAQ8"/>
    <dbReference type="FunCoup" id="A0A401GAQ8">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAQ8"/>
    <dbReference type="GeneID" id="38776162"/>
    <dbReference type="InParanoid" id="A0A401GAQ8"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="145" mass="16357" checksum="EDDD6B6AB81F673D" modified="2019-05-08" version="1">MSDREGHPGAPGTDEELSLPKATVGKMIAELLPSDVSCAKETRDLVIECCVEFIHLISSEANEICEQESKKTIAPEHIITALKRLGFESFTEEVQDVLKDHKQQQKDREKKVSKFELSGLTEEELLRRQEELFAASRAKFQTAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAX7</accession>
    <name>A0A401GAX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pantothenate transporter liz1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0205340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610249.1">
        <property type="nucleotide sequence ID" value="XM_027754448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAX7"/>
    <dbReference type="FunCoup" id="A0A401GAX7">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAX7"/>
    <dbReference type="GeneID" id="38776253"/>
    <dbReference type="InParanoid" id="A0A401GAX7"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE79336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="487" mass="55252" checksum="130E85236AEAB698" modified="2019-05-08" version="1">MTVMASLRKVRRFVWGEIPATKAEQKLLLKIDWFILSYCCLMYFTNYLDRSNVANAYVSGMRQELHMHGTQYNKINTIFTCGYIVGMIPNNLMLQVVSPRIWFPTMQIVWGVLTFCSSTVKNIEQLYAIRFFQGVTEASTFVGTHYVLGSWYRRGELGKRSGIFTSSGLIGTLFSGVLQAAVYKHLNGVSGRSGWRWLFIIDGVITLPIAFYGFLVFPDLPATTKAFYLTEEERVLARERVETTKKSTHGKVTWDLVRRILGRWRWYGCSLLFAVSGETESFASNNLMGQFLSALGGYTVEQVDYYPSGVTAVGIASTLICATWTDSTRSRARWPVLVWMCFAVIVASICIVVWSSPIGLKFFAYYLAGASYSGQATTFAWANQICYDDDQERAVVLASMNMWNNVINAWWPLIFYRATDAPRFRRGMWAMIGTAVATLGVTWLVWFLERREKRGRGKVGVEEGAEERDDEQNEKGQIDEVVIAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAX8</accession>
    <name>A0A401GAX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610220.1">
        <property type="nucleotide sequence ID" value="XM_027754419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAX8"/>
    <dbReference type="GeneID" id="38776224"/>
    <dbReference type="InParanoid" id="A0A401GAX8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="20577" checksum="FEBC7F468E8DA80C" modified="2019-05-08" version="1">MSKAGGLGEPGEVHMRLDASARGTQVDDDGRSARRRDGRSRSAGAMPDMAGIERRGDWGGRWGAARARGEELSTDCGVEVTSCRRVAGGIAGGRRARWRGFDAERKDSAQVWDWKMRSFSELRRIAGPEGPEELRSLKAGEAYLRVEAGAGVEGPRKQLGVRTPWNGGSQWRVDGGRVPRIVRSESRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBY3</accession>
    <name>A0A401GBY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0208510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610564.1">
        <property type="nucleotide sequence ID" value="XM_027754763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBY3"/>
    <dbReference type="STRING" id="139825.A0A401GBY3"/>
    <dbReference type="GeneID" id="38776568"/>
    <dbReference type="InParanoid" id="A0A401GBY3"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="88697" checksum="9A313DBFECFBD8BC" modified="2019-05-08" version="1">MPVPVPLYTKQPAHPVIKTNRSIDSDYEPSVFQHLTQPPLPPRGPPPSLATREEWISSLPSWRRNKPRRIWEEDIGRFQGCVPQDFEEGLAVAGNAAVSKGAPAQACIPPVSTLVTTAGLALSSPLIDMYPDRGVEPDHRMDIYSPTTHGWPYEVGPQFPTHPSANNEEYEDLTMENDSDSAMDYGQYDIGRSAPLGDNGEDGGSSGLYIEQDYQRGAFSPVFEDISPERADMHDPASSPMGPATPFADFVDRAVAEAHVVMSYDAVQPVNNSREMQYGYHDDYSGDVCYECQAYRHAEQHVQVQVPVPEPVVTPTATTAYKRLAEPLSEWIATYVWKVCTTGTSLPPVYQPTAYTKHYSSMPPSHLASSTHAMLLSTLLQPSAVYLALWYIVHLPVFFGPTGLGSQNGVANRFVAEFLGEGRMSLDQDAIEAYAPFRLILLGCMLANKWLDDHTFSNKTWHTISHVPVQSLNRLESLALDLFDYDLSISPQQWSDWLSHLLSYHASLSSSSCPQPISRPSMDPHTIIRKAIETLIQAEAPAICQCCNEKICTYCPPEPIFVGIEGRRGEKVEVEQPYDVDVLEIDLDEDGPLREEYLPRRRISGAGSTRRSQMQEKAMEADRILPPPAKWSPSADEPIMRDGTRAHAQYVAVQPIMAVPPPPPLPFHQVLDPHRQTWSMAGYVSKQEQVSAYGVPVFQTQAPYIAYDYTYPLSQTHSRSQSLSYHQAIDGSSQGRVRSYSQSRYEPGYSEVRFSYSQYPPPNVPVSRWLNVDPRYAKCYDAPIISQQRTSLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCT0</accession>
    <name>A0A401GCT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein SVP26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0211640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610875.1">
        <property type="nucleotide sequence ID" value="XM_027755074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCT0"/>
    <dbReference type="FunCoup" id="A0A401GCT0">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="GeneID" id="38776879"/>
    <dbReference type="InParanoid" id="A0A401GCT0"/>
    <dbReference type="OrthoDB" id="28257at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144:SF0">
        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="37359" checksum="3B5DCDD94B15C3F9" modified="2019-05-08" version="1">MTLLHSLSYVGAAMAFIFVILSLASGLLWLSELIEEHSRTSKAVGQRSTYGIIILHILLYLSDSLPLKLIMFSIFCHIVYLQNFTASWPFISLSSLGFVASCVLVVLDHFFWFFYFSRITQETRHRSQRTYRSPQDSQAAPGFAEIATFFGICVWFVPLFLFLSLSANDNALPLSAENNIIPATPTSPSKPIMTRPRASLFKSLYDRMPRLRPKQRRRDTSEGIIAPRSPSLVRVPSSPTPGQSSIGLQRVPSMNSLPPPLLSPTPPLRRLSSDSYAHPPSPGMLAAGDTVFDSPQPSDRLTKFALGSPPRRVTGRPLDDRRLEMRRATSAYAGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCU5</accession>
    <name>A0A401GCU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0212100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610921.1">
        <property type="nucleotide sequence ID" value="XM_027755120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCU5"/>
    <dbReference type="STRING" id="139825.A0A401GCU5"/>
    <dbReference type="GeneID" id="38776925"/>
    <dbReference type="InParanoid" id="A0A401GCU5"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19489" checksum="74115C236433BF44" modified="2019-05-08" version="1">MWKTALLLLGAQAEDGMDADDTRINFLTTMMRQHADERESILKELVLQLIHAGQYRKALDELELFLPSLPYQDNPVLHVYAGLICLYLAQPKANALIADELSDESGWNAGLLREAQGHFERAKAIDADNTVATTFLEQLPTITNPAQPDRTTPESDDEDVTVDDAGQRRKRIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCZ1</accession>
    <name>A0A401GCZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0212170</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610928.1">
        <property type="nucleotide sequence ID" value="XM_027755127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCZ1"/>
    <dbReference type="STRING" id="139825.A0A401GCZ1"/>
    <dbReference type="GeneID" id="38776932"/>
    <dbReference type="InParanoid" id="A0A401GCZ1"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="51"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="116"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE80015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="292" mass="32279" checksum="A927D5F428BB6534" modified="2019-05-08" version="1">MSSPESYEYLLPPSWKPQVTAWLAEDTPSFDYGGFVVGEAHREAFLLGKGKQTAVLAGAPFFTEVFTQLGCEVEWHMRDGETFEPVKHVATVRGKARHILLGERVALNLLARCSGIATKSKTIKDLARGYGYKGIIAGTRKTTPGFRLVEKYGMLVGGIDPHRHDLSSMIMLKDNHIWSSGSITTAIQQARKVGGFSLRLEVEVGSEAEADEAIDAGADIIMLDNMEGDQLVSVARELREKWSGKRKFLFESSGNITETNLQERAINEIDILSTSVVHQSVQHIDFSLKIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD79</accession>
    <name>A0A401GD79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Transposon Tf2-6 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0212760</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610986.1">
        <property type="nucleotide sequence ID" value="XM_027755185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD79"/>
    <dbReference type="STRING" id="139825.A0A401GD79"/>
    <dbReference type="GeneID" id="38776990"/>
    <dbReference type="InParanoid" id="A0A401GD79"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="259"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="813"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="1112"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE80073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1166" mass="133864" checksum="83DAD5815D9DFE40" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGKDAKWPPKPTVEDAPDEEVSIFKEDGLPELITTETSPTSFRHSESIREITADNTERGELPAVRNDTEPDDPPSETPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHCTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPHDCKVYPLLLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVRTRHVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPTTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGDLHPCAYISQTLNPAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSRRNGLDDSESDNEDRILLPNALFVRSISPTLFDEIRNHAAKDLIVHEALKAIAHKGPFPMKSSLSDWEVRDGVILYKGKIYVPPSETLRRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLRLYCGNNPETWADRLPDLEFCHNTREHSARKMSPFRIMMGYEPRGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIAEVIGPANYRLKLPKTWRVHSVFHAALLSPYHENDIHGPNYVNPPPDVVDNEEEYEVEAILNHKTYRGHLRYLVKWKGYSSAENSWEPAHNLQNAKRILDAYKRTRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDB7</accession>
    <name>A0A401GDB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0213630</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611070.1">
        <property type="nucleotide sequence ID" value="XM_027755269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDB7"/>
    <dbReference type="FunCoup" id="A0A401GDB7">
        <property type="interactions" value="908"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDB7"/>
    <dbReference type="GeneID" id="38777074"/>
    <dbReference type="InParanoid" id="A0A401GDB7"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="248"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="387"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE80157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="445" mass="50446" checksum="128D693996B31B94" modified="2019-05-08" version="1">MSVLFETSLGDIVIDLEVEACPKTCENFLKLCKVYYYNLNAFFNVSKDFLAQAGDPSATGTGGESIWSLIASKQGQQQQAPRYFSPEFVPRLKHKARGTVSMAVAPAIDGTRGGGCGSQFFITLADEIDYLDGKHAVFGHVVEGLDTLEKLNEVFTDQEGRPLKDVRIRHVEILDDPFEDPPGLVVPESIPTSPPDNSTRIAEDEDPLATLPEEEAEAERRKQAARASALTLEMVGDLPFANVRPPENVLFVCKLNAVTRDEDLELIFSRFGTIMSCQVIRDKKTGDSLQYAFIEFDKREDAEQAYFKMQNVLVDDRRIWVDFSQSVARLNTHWSNDIKIGPRLGRGGGGRGRGGGFGGLENLEETRRYREGSRGAVNGYGMVFDVPEDRHRRRNRSRSVTRDKEYGRRSRSPQHRDRGERERHRSRSRDHNRHSRDHYDHDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDL0</accession>
    <name>A0A401GDL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0214610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611163.1">
        <property type="nucleotide sequence ID" value="XM_027755362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDL0"/>
    <dbReference type="STRING" id="139825.A0A401GDL0"/>
    <dbReference type="GeneID" id="38777167"/>
    <dbReference type="InParanoid" id="A0A401GDL0"/>
    <dbReference type="OrthoDB" id="2796020at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="13606" checksum="AAD5DE6F03661AA5" modified="2019-05-08" version="1">MNVKSAFLHGDLDEEIYMNILLSFCKDNKLIWRLNKALYGLKQAGHEWYKKICADFEALEFTRCNLVHSMFYKNDNGTLLVIAIYVDDMLILSDNPAAVNTLKDDFKPCFEMTDLGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDN1</accession>
    <name>A0A401GDN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0214450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611148.1">
        <property type="nucleotide sequence ID" value="XM_027755347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDN1"/>
    <dbReference type="FunCoup" id="A0A401GDN1">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDN1"/>
    <dbReference type="GeneID" id="38777152"/>
    <dbReference type="InParanoid" id="A0A401GDN1"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="899" mass="97165" checksum="29A313A98B753F12" modified="2019-05-08" version="1">MADSFADLWNSTAPTKPPEPPRKLGSLTPIVSSARPPQNDVFSMLASASPSTRNSRSNTPSATGPLQSTRSLGTSSPAIPKPVQKSTSAGGDAFSSLLAGPFASSSTSANMTIAERAAKAERERKEQSHGAQTVSKHQVAAWAGLDSLGTTSFGAKSSSATALVKIQDDEWDFVSAPSKTQSVAEPPPPADVDLFDEFLSQPAPLRPAPSQAPQSILDLDEFTSPSVLSNFRHSPERPTSRINSPGDFDFGDREDALLDDDSNDEDDILGALSKPVDARAQPPARSVQDTPQSSQVSTSGQRSRAVSPPPHIVGQIVEMGFSPEQARIALAATDTGLDVQTALESLLAAASNNGTQTPSREAPRGNAPRRRRERYEESDEDEHDEDSSLRRRQAPSKRGGPARPPREPPARDGPSSSPAGASQHNLQEQADKLLAQASEIGLNVFNRANAFWKEGREKVQRAYEERAAAAASAKAPTADKARNARPKWMQDVPEHAHVEGIRHDCVEFSDEPEVLPPGPSSQTRPRKLTNHARPAAAPAAMTTNLLSEDAPAMYVSPFRRRIPAQVPSTPPVRPPSPVKLIQRKAISASPTAIAASAKHKAAGTEMFKLGRYVEAETSYSAAIAALPESHLLLIPLYNNRALTRIKTGEHTGAIEDCTNVISIIGLNYHPAREEKVTKEDEGAGIDLADGLMKAFRRRAEAYEGKEKWDLARQDWETIAAAEWAAKTRGEAVRGAGRCRRMLSADVDTLAPTLSAPASRPPSQPKRKPKPQPVQRRPTPTSEALNRVRAANQAAEAEDQQRYELKDVVDSRLAAWKNGKELNIRALIASLDTVLWPDLGWQKVGMHELVTPSQVKIRYTKAIAKLHPDKLSVNNTTLEQRMIANGVFGSLNDAWNAFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDW0</accession>
    <name>A0A401GDW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611285.1">
        <property type="nucleotide sequence ID" value="XM_027755484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDW0"/>
    <dbReference type="GeneID" id="38777289"/>
    <dbReference type="InParanoid" id="A0A401GDW0"/>
    <dbReference type="OrthoDB" id="3147730at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17649" checksum="0A612122C2F07CED" modified="2019-05-08" version="1">MDQMIPYDAICFPADDRPPHLVSLMTTVLNVVLPNPSQPYRCSHMPHPEIHIDYIAEGLGPRSWQYHLVEALDGMNKKFTTPYILFYPIVSRDGMPFPVNKCIREIQGACFNEAKAWRGNIVVAKYRDADYSQMAEASMADFPILKNYLKTCPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEX1</accession>
    <name>A0A401GEX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0304450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611639.1">
        <property type="nucleotide sequence ID" value="XM_027755838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEX1"/>
    <dbReference type="STRING" id="139825.A0A401GEX1"/>
    <dbReference type="GeneID" id="38777643"/>
    <dbReference type="InParanoid" id="A0A401GEX1"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="111"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="255" mass="29517" checksum="ACA3A09AC91F488A" modified="2019-05-08" version="1">MSIPDERFFPYATGLAAQTVEKHQQPQDLIFYAGWFCPFVHRSWIALEEKGIPYQYKEVNPYKKENHFLEINPKGLVPAVEYKGKALYESLIICEFLEDAYPSYTPLLPSDPFERALVRLWVDFISKSVVPAFYRVIQAQDAEKQKAGLDEFNRVLRTLSEQVKGPYFLGDQFSLVDVALAPWVARDYVLQEHRGYTREAAGAGWKEYAERLENRESVLKTQSDKEHYEEIYDRFLRNEAQCEVAKATRSGSGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFR0</accession>
    <name>A0A401GFR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Anaphase-promoting complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0307250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611915.1">
        <property type="nucleotide sequence ID" value="XM_027756114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFR0"/>
    <dbReference type="STRING" id="139825.A0A401GFR0"/>
    <dbReference type="GeneID" id="38777919"/>
    <dbReference type="InParanoid" id="A0A401GFR0"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015671">
        <property type="entry name" value="GSCR1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15249">
        <property type="entry name" value="GLTSCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="12"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="GLTSCR protein conserved" evidence="10">
        <location>
            <begin position="766"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="966"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="642"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1114"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE81002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124061" checksum="A890C7214BC2F9A8" modified="2019-05-08" version="1">MAYSSVDAAMVVALRNAVSDCTERGLIFASKWASELLLSVPQDKRRSARSAAQEHGSSIPARKHSPRPHVSFVKPAAQSSTTTQSRHSLAPPLYAQPPEVRQQELEWEAEEDDAIATARTYIEAREFRRAMHWLRECKSAKARFLSVYSQYMFAEKQALRDWYKLDNTRQQPPLPVNTSLLELLEKVKNTTDPWLLFLKALFLRRLSRREEAIESALLSIAGYPWNWAAWSVLGECLGDGDELASLLPLIPLPSIHPLVQMFQVKTLNSLNNPSENERRLCDHLLGEDFFPQSLWIMSLRACVLYYLHDFKQAEAQFKKILAVDPYRIDDIDIYSNILYVGEDNLRLSKLAHDFLALDKDRPEVCCLAGNYYSLRAEHEKAIKYFRRATQLDRTYLSAWTLMGHEYVEMKNSHAAIEAYRKSVDVNRKDYRAWYGLGQAYELLSMHQYALYYYQHATALRPYDLRIWQAQGACYEEMGRPKEAIECLRRALIGANAQETTIHLKLAKLHNDLNEFAEAAAYHRRVVEVCRSTNKPIGESAKSRVYVARYHLMHGGGDLDLAKEYLEQVATSNSEEVSQATELLKKVKAAIHAKEASTAAAEATAERLESHGHAPSHAHGTGKRDANATKQKRSPAEMSKKQPSSSSPSPSSSSLTRPTPLPRIKTALDAASPALASQSATPAPDPSTPAVASTSAATPEYAHPGVLDDVRENGRAHEGVPQTNYIADLEAIAARVEMKTAARGRTPEEEQSMLLAATQVATSLAADHLAVLYPDVDTPFTDAQDVVRRLLPYHVFQQPRAGLVVQTRTRSRKGKSKATEQDLLRDEIAETRFALQCWRRRKALQDRFRRAKIYSGKHASPEDQLYVLTQTVLEGERAETASLNAELRHARVELDRVQREHRAAVAPPPAAVPQPAPSYYGPHTTTGYASQYRPFTYPYGTGYGGSQYTYNPAAYTPASYTASAPTASPYGTGSGSAAAHTTSTPTSVYTPPSAVPAQAATSTASVQVQQAQARPLAVPPMSAIPVQLPSLSLPALAAIGIQPVPAASVPPPDQRQPAAVLKGQTGTMLSLEINVGSLDSSQMSGLALILNALTSRGVNVDGVPGSTGASGGGPAAAPAAAAASASAGTSQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFS8</accession>
    <name>A0A401GFS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0307530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611943.1">
        <property type="nucleotide sequence ID" value="XM_027756142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFS8"/>
    <dbReference type="STRING" id="139825.A0A401GFS8"/>
    <dbReference type="GeneID" id="38777947"/>
    <dbReference type="InParanoid" id="A0A401GFS8"/>
    <dbReference type="OrthoDB" id="2803547at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="446" mass="50024" checksum="07F7E48A04BBC112" modified="2019-05-08" version="1">MDAVHSSSSTSLQLAETLLPAIEQERFDLSIDNIKALEEMLVASLSLIRNAYNCSRPVNRIPPEILGQIFEDALRPLEYSSCAFVWPFASIRDTHALRDVTRVCRYWRDVALDLRLLWTHICFSEFHPVSPAYLKRSELAPLKVLINDDVSSKCLSRLLQSDGSRIQELHAYYTQTFWNTAVPAPNLEYLSVKEIGSPNGEARPLLFCGEAPRLKALTMEEIPWLPRNGFANLTHLCIRFAWPAWYTPVWKVSDLWEFLTGCPRLQDVIMVAVPLEATRAHEDLPVLPLNDLRRLSLGDMSSGLITWILAHIPRSSALADDHPTKLRLTLPVPGSVTVTAVDSASGLQVECAHPPSDIRRLDWTPSVWEPWPLSSVRELWISDSKDGLEGWRCLSGLLPLLPSLTTVVYCARDRWAQRGLDYLLDSLSGSSVASSVPCPALANLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFT7</accession>
    <name>A0A401GFT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0307810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611970.1">
        <property type="nucleotide sequence ID" value="XM_027756169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFT7"/>
    <dbReference type="STRING" id="139825.A0A401GFT7"/>
    <dbReference type="GeneID" id="38777974"/>
    <dbReference type="InParanoid" id="A0A401GFT7"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="226"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="665" mass="71724" checksum="6D0BE6246C791D9D" modified="2019-05-08" version="1">MKFLCHIAAVFAVFYLTVVDQVFSVAAAVQVPLSLSGSTLILGGVSYFVPPSPVSKFEADGLTERITKKLGRNLIPFSILPTSLVHFDENAFAETLSGWATQDDVWSMPFLTGVYITFNGSHSSPSISSGVIAAQEKYGVDFILYSTRYAGGLDPSQPLPSGPYFLEPLTGNIYEAYRLYNDEQQSFLYGTVPDKNGSFQVLPAKIPGAATETIAVPSRLYFSPTAEKPFAGFRLAVKDIYDVQGLRTGCGNRAYFNLYPPKNRTAPALQRLLDAGIVLVGKAKTSQFANGEVATDDWVDLHAPYNPRGDGYQDGSSSSTGPGTSMAAYPWLDFAIGSDTGGSMRGPAGANGLYGNRPSHGAVSTDDVMPLSPELDTLGIFSRDAKSWAAVGHWWYENFTSYSQYPQTILFPVDAFGGSYLSQPPAAGTTAATFNTFIGKLEKFLGTQRTEMNLTALWTETKPSNISASLREMLNTTYPILIASDQTSLLADPFLADYAAANGGRKPFIDPAPLTRWEYGWSLPAEAHDEAVVNKTVFMSWFTNEVVKGGNSDTCSDSVFLYPQSSGATNYRNAYSGPPSTPFGFSSGRIAVLAETPDMVVPIGEAPYNSTITGQTEYLPVTLSFISAKNCDLMLFNLFAALQDAGVLNPVLTGSRLFVEAAIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGY4</accession>
    <name>A0A401GGY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612294.1">
        <property type="nucleotide sequence ID" value="XM_027756493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGY4"/>
    <dbReference type="GeneID" id="38778298"/>
    <dbReference type="InParanoid" id="A0A401GGY4"/>
    <dbReference type="OrthoDB" id="10261040at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="222" mass="22957" checksum="91BCED507285BF8A" modified="2019-05-08" version="1">MSGVHSAVVKNSNGQSLLQVLPSPLPYLSGSAVVSTLSTLYGAEKSSTAQLSQTGVIALLPPLLSANTFNVEAQDYLTALTLSANAAANALACGSVLAGQTSETDEFGDLALWLGEGHYGKGHEREVLEALGLHGALGPQIKITPVDIPAAMHLPSNLTELVARSSEGKRLSSLLSQLDHIYSFTVQPMPAGGGSVAQFLLGHRSHEGFSGWSGLVGIGVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH70</accession>
    <name>A0A401GH70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612450.1">
        <property type="nucleotide sequence ID" value="XM_027756649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH70"/>
    <dbReference type="STRING" id="139825.A0A401GH70"/>
    <dbReference type="GeneID" id="38778454"/>
    <dbReference type="InParanoid" id="A0A401GH70"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052926">
        <property type="entry name" value="Metallo-beta-lactamase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754:SF13">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="366" mass="39905" checksum="E5D8B28691E5672C" modified="2019-05-08" version="1">MTSTKSVDRLVVRFVVDNCIEWMTKLPPGFTHEMRQHLAEQEPPVDPLTGVPFLDLEHYCCGAHGFSALIETQLEGSPPHLTLFDTGPDSRAIARNLDSLQIPIERVERVILSHWHADHSGGMLTFLRLRAAAQVKQPESERTPCAVDLHPDRPIARGISYLDKILGRLPDDPSFQQIEAEGGVVEKHGEGHAVSGDTVWVSGEIPRVTPWECGISGGLRWVGSEGVQGKGGEWIKDEEIMDERYAAIDVAGKGLVIFSACSHAGIVNVVRDAISKFSRQVYMIIGGLHLAGPELTERIPPTVKFLTEKMRPAPAYVLPMHCSGFAAKVALEAALGEGCVPAGVGMKVEVQGDRDAEKMMMLPTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHR8</accession>
    <name>A0A401GHR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0400260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612568.1">
        <property type="nucleotide sequence ID" value="XM_027756767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHR8"/>
    <dbReference type="GeneID" id="38778572"/>
    <dbReference type="InParanoid" id="A0A401GHR8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="113" mass="12078" checksum="8A707C76525804F9" modified="2019-05-08" version="1">MGYSRLAFVFQTQAGESSLLNLPPSPFTAFKVRRLNTLTKSASTLAKPRWREVSHDGGSPVLSRSSSVSTSGINVEVVPPTDDEGASDEEEAEPTPTKVEAAQADSFAEPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI06</accession>
    <name>A0A401GI06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0401720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612712.1">
        <property type="nucleotide sequence ID" value="XM_027756911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI06"/>
    <dbReference type="GeneID" id="38778716"/>
    <dbReference type="InParanoid" id="A0A401GI06"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="170" mass="19676" checksum="1A0EB47A29E00F0F" modified="2019-05-08" version="1">MRTAVQEQERRLPTALAVAYNRETNVYAFGASVAGSKVRKPEQVEHRSVAYAGERWYQEMAQEYQQERAENSLANRTVRHAPGNCAEWNTTRQVAGRSQTVYSMTMNTRTSAVMNWCDYCQTMVKNVIREYDGMVVHEYRDMEGKRRIHCWRDGTYHVEEYTGSQSSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI91</accession>
    <name>A0A401GI91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0402040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612744.1">
        <property type="nucleotide sequence ID" value="XM_027756943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI91"/>
    <dbReference type="GeneID" id="38778748"/>
    <dbReference type="InParanoid" id="A0A401GI91"/>
    <dbReference type="OrthoDB" id="3241835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="160" mass="18278" checksum="43F82F10D80C38DB" modified="2019-05-08" version="1">MRRSESRFPSFSLSSSKTRQLPLYSASSFIRQSLSSPSDHQLPSYGAVNSTRRAGYLKRHPPPYEDLMKTVDYRHTEEPPRYRSSFALSDIFEDDEIEIEISSILPSSTPRAESVHGRAHPPRLCAFMRNILSWLKIRCLRKRLLAPTPDAASIMMHGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIP5</accession>
    <name>A0A401GIP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
            <ecNumber evidence="3 14">2.4.1.258</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dol-P-Man-dependent alpha(1-3)-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0404200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 14">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the first dolichyl beta-D-mannosyl phosphate derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-dolichol to produce Man(6)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29527"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="Rhea" id="RHEA-COMP:19517"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="ChEBI" id="CHEBI:132516"/>
            <dbReference type="EC" id="2.4.1.258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12 14">
            <dbReference type="Rhea" id="RHEA:29528"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyltransferase ALG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.258" evidence="3 14"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612955.1">
        <property type="nucleotide sequence ID" value="XM_027757154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIP5"/>
    <dbReference type="FunCoup" id="A0A401GIP5">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIP5"/>
    <dbReference type="GeneID" id="38778959"/>
    <dbReference type="InParanoid" id="A0A401GIP5"/>
    <dbReference type="OrthoDB" id="20028at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052925">
        <property type="term" value="F:dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007873">
        <property type="entry name" value="Glycosyltransferase_ALG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646:SF0">
        <property type="entry name" value="DOL-P-MAN:MAN(5)GLCNAC(2)-PP-DOL ALPHA-1,3-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12646">
        <property type="entry name" value="NOT56 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05208">
        <property type="entry name" value="ALG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE82042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="421" mass="47748" checksum="ABAFC7D504B2469F" modified="2019-05-08" version="1">MSLPSPLARLVNTLSASLHSLLTDPHYFYALATLVVLGDAVLTQLIIRFVPYTEIDWETYIYQLELYMKGERDYALISGPTGPIVYPAGHLYVHRLLYAITDSGKNLVAPQEVYSLLYIALLAITCIIYRQAGDVPNWILLLLPLSKRLHSIFVLRLFNDCWNVFFAHAAILAFGYGWDIPGILLLGCAMSIKMSALLYLPGLVVVLFKRRGFLSTLAHVSALALTQLVIGLPFLWQYPLSYLKYSYQFSRTFLYRWTVNWRFISEETFLSSAWAKGLLAGHLTTLVAFGLFKWCKGDGGVWYVVSRGLRTPLQRPPVPPVTADFVTTVLFTSNLIGILFSRSLHYQFYSWYAWQLPFLAWRTKYPVVIKLAILLAIEYAWNVFPSTPLSSSILCGANMLLVVGLWFGYPEGKKDIVHKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ98</accession>
    <name>A0A401GJ98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UEV-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0406080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613138.1">
        <property type="nucleotide sequence ID" value="XM_027757337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ98"/>
    <dbReference type="STRING" id="139825.A0A401GJ98"/>
    <dbReference type="GeneID" id="38779142"/>
    <dbReference type="InParanoid" id="A0A401GJ98"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="502"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE82225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="62935" checksum="DCA18CAB43A97626" modified="2019-05-08" version="1">MAASLMHRWLRQNIQPYAHQDVVFPDVAAALARYPTLRPKTDVYTYDDGRTQLLLCLHGLVPISFRGAAYNIPVAVWLTREHPREPPIAYVVPTADMLVRPGSDVDVSGKCHIQYLSNWEHKPEGCNLTALFEAMRDAFSHLPPVYAKPKPVAAPQPTRAATTGPDYSDRPPPPLPPATPSQSVPPAPAPEHNDGRPPLPAKPGAPAVSATAAPHARTQGVPRSPTLLATPALALRPPPPLPPHTPPAEPPLLRHPSSPVPPTYTPRAQSDVPRPQAPPQLPSAASPRPTPPLHQPARAVASSSPPPLPPLPNVASPVGLPQHMYPTFPTLHSPAPSLPPPFLSPQSTDRAAPPIPSMPLQHTSPPAPSIPPPDLLDADDTTSGPPLPSSTSPPPPGPAPPRPPNPELLRLHASVHARFTSELHALTHALSRDAERLRAQQADLLAGEPALRDEMGRLRAVRDVCEGVAARLRGAVERGERSVAELRRKGDPEVDELVCSTTIVYNQLINLVAEDNAIEDTIYHLHRALNTGRIDLERFLRTTRVLAEEQFMKRALIEKIEAGLPRDTAAAAPWGVVPDFASWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJN9</accession>
    <name>A0A401GJN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0407710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613300.1">
        <property type="nucleotide sequence ID" value="XM_027757499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJN9"/>
    <dbReference type="STRING" id="139825.A0A401GJN9"/>
    <dbReference type="GeneID" id="38779304"/>
    <dbReference type="InParanoid" id="A0A401GJN9"/>
    <dbReference type="OrthoDB" id="2793221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="9">
        <location>
            <begin position="607"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123425" checksum="A501AEDE874FA543" modified="2019-05-08" version="1">MMEQCLQQHYDSASAPAHHEELQDLRIQHEQFVDNAQAQLASLQAENVHFTTTLQHVNTTLTAMDSTIRQLSQYPGPTEPHGEDTRGRGFQRPARRANTSPPPTDRPPKRRRNEYNRYYDRRDRDHSPPPQMPMASTPSAGAMLLAMPPRSAAPVIAPSLPALSVAPVPPLPVPPPQVQLPLPVPPTMPVPLPLPIQMDTRRIMRLGPIAWDLSQARAQLLAIVHASGSPSSFPTSDIIETRPDDDHQYLCIVFRSSVAADAFVDAWRRNCPAQYNFVVPHLLPRGHCTIRLLSWNVNGRLALKLTDSMFVSYLFQYDVLLLQETHLRPEEHDVLIFPEEYDMIAVSRRNTPTMQQPGGGVAIFLRCQIPRIVLTSLCTDDMLVVDLNVCILINVYLPPETSPWNLLPPAQPEQRLKETLAVLGRCPDKPIIVAGDLNARIAALSPTNSDHIRQSPDVASLNSRGRRILQLCDDFDLDIVNGTSLQVPSSLHSFTSLQPAGSAIVDYVLASAPLDRIVHSLDILPHRPEWTDHSALRLQLHHPTYSTELPAASNHKLKQHRQYSHIPSSAMGPSPSTALDTILHKTLLAVETPEAALQRLYGPVYIDTPPVSVYTDGSCMRQGTPTAAAGAGVYWGPNNTRNNSIRVPGDQTNNRGELFAILHALMVTSPSRTLRLYTDSTYSIHSLCHWAPQHASLGWSCANADIMRDAVAFLTWRIAPTVFIWIKGHAGNAHADAADALAKHATVLPLHDNDYCSPVLPPPLDTSSYGTTLSMPKVTTNLLPLPCSPPHCNPSPKLPTHVSHRGRTRLRHMMDCNKEKLLHCANDRAFWSLIRQWTNTQPRPAQVTVDQLHDVFRARMNPPEAFPVEFNDVRHVLNHCCANLLPQRTVDTTPQRFFSRAFTIDEIAHAKAHIKLHSLRSARGADRVAYITILAIPNEQLLLLFEQCLAQCDAPQIWLTSLLAAIQKKGKSAADPAGYRTIGLESCLLKLLTLLIDRRLRAWSDAGGIIPPSQNGFRANHRTNNNAFILRTAIETARSKGQTLYVAFVDLTNAFPSVDHATLWVKLQQLGASGPLLDWLRMLLIKSQYADLVGDSNNRTEELGNTARVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJX3</accession>
    <name>A0A401GJX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Probable sulfate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0408510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">High affinity uptake of sulfate into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613380.1">
        <property type="nucleotide sequence ID" value="XM_027757579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJX3"/>
    <dbReference type="FunCoup" id="A0A401GJX3">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJX3"/>
    <dbReference type="GeneID" id="38779384"/>
    <dbReference type="InParanoid" id="A0A401GJX3"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902434">
        <property type="term" value="P:sulfate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000046">
        <property type="entry name" value="Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="532"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE82467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="756" mass="83138" checksum="D2BCE65FA3BD3ADB" modified="2019-05-08" version="1">MFSTAKRYGKRIIGYPEESVPVVSVSDWVRHLSRDPKREVLHYFRSLFPIIGWITRYNLGWLYGDVVAGLTVGIVAVPQSMSYATIATLPPQYGLYSAFVGTFVYCLFATSKDVSIGPVAVMSLTVSQIIARVNKAHPNVWSSPQIATTLAFICGWITFGLGILRLGWVVEFIPAPAVGGYMTGSAINIVAGQVPGLMGETGFNTRADTYEVIINSLKYLPKTKLDAAFGLTGLASLYLIRIFCDILSRRFPRRKRIFFFISVFRNAFVIIILTLASWLYCRHRRSKSGSYPIKILQTVPRGFHHVGSPVIDRQLVSALAGQYPVATIILVLEHIAIARSFGRRNGYKINPNQELIAIGVTNTVGTVFGAYPATGSFSRSALKSKSGVRTPAAGILSSIVVIVALYGLTSAFYWIPTAGLSAVIIHAVADLVTSPRQAYSYWRVSPMEFVIWAASVLVTVFSTIEIGIYTAVASSAALLLVRIARPRGYFLGKVTLRGDKRDDVSETRDVFVPLNPKPTVMNAAVKVTPPEPGVIVYRFEESFLYPNSYLLNSVIVDYVKEHMRRGRDMAAVKLSDRPWNDPGPRPGHDESAENLKRPELRAVVIDFSGISQIDTTAVQALIDTRTELERWADHPIEFHFATILSPWIRRALIAGGFGTGVASSSIPLEIAPVVPYRGGRKVPTPDKLHDEESGGSIQQVPSHLQDVEDESEPISLVDTPFFHFDLISAVRAAESGLARLHSQTSTTKSDLKVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL66</accession>
    <name>A0A401GL66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0413000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613826.1">
        <property type="nucleotide sequence ID" value="XM_027758025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL66"/>
    <dbReference type="GeneID" id="38779830"/>
    <dbReference type="InParanoid" id="A0A401GL66"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="145" mass="16054" checksum="4CB572C1AD022AC8" modified="2019-05-08" version="1">MFHVAIASHLTIQSTRRRPSWRCRLHHQAEYTSTLEGPGANSRMNTELDPLRQRRPKHVEDHTGNAAVQPYTLDTRSIEPDAAMERIKLARCATNTATVSGALRPPARFMPSRQCNGLSGAAAKTAVMNMMRYIAALVSLKQSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL77</accession>
    <name>A0A401GL77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0413140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613840.1">
        <property type="nucleotide sequence ID" value="XM_027758039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL77"/>
    <dbReference type="GeneID" id="38779844"/>
    <dbReference type="InParanoid" id="A0A401GL77"/>
    <dbReference type="OrthoDB" id="2739948at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="262"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="431"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="888"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="922" mass="105659" checksum="1876FC9C43C6A0C1" modified="2019-05-08" version="1">MSSTKSLQSDNLSANCQSSPHKAKRDNSRFATGGQTLHDQRRHLREEMRGKFIVMPVDKFMDAFTPESEAMVEKPFKPNFKKVFKDMENVLEGTVREEQMYEPLVKCVQNYKLCTGYVLKLVQNKPDKADPSRQKVDAALFLPENAKQRKSFDDSRPHWSLQRLSIEFKKHRTEDDPFEDPKTKAEDEDDLHHDAEQGDEVQVDDVHDANDDDVGDMDNVFLDEDETYGDGDPTMGDGEDSEEENSLQMASEKSSREVFETAYEPPADRRAAARGQIISYAKMLFSRQHRCFAFTILILRDLARIIRWDRAGTVITNKFKYTNTEYLGKFLWRFCNMTDKQQGYDTTVVAVKPGSADYKLMEQLAKNPPKGAGSEYARQSFAKSVPNLSKENPDDWSCWKLTVHPEKGKGTDGSDSRPAGRNVRKKPRFRHFLVGKPHFQASGMTGRTTRGYIAYDCQDKKFVFLKDVWRVDLPDIEKEGYILQSLNDAEVANVPTLVCHGDVLDVENVGNTVHVERQRTKTDTYWREFYSGQMNPIKTHTHYRLVVEEVCRPLSDFKNALELVRIISDCIYAHHQAMVRARIMHRDVSAGNILMNEMLLPSNGDVPWRVGMLCDWELSKLIDDEDGEVDDTEGIQKARQPDRTGTWQFMSAILLDVPARAVEVADELEAFFNVFLFYLVRFMNSSLKNPAYFMSQYFDECTVSDGATHYTCGIAKRNAMQSGKLQTTLDKTVRFEYGDKKTHPCNALIHQLLKWFKARYAEFSPEDWPQGAVQNGPVTDEPQQPNDGIENDEFSADTEMSIRDHLRRQVMARSLATGMSVETFKEDPQIEGKAREEQKALANNLNSQVPMYRLLEEAYNQHVDEWPKHDKVLDRVPSNYNYAHYKEKGLELPAVPTAPSGSKRRLEADMQGARQSKRSRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLB6</accession>
    <name>A0A401GLB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0500060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613876.1">
        <property type="nucleotide sequence ID" value="XM_027758075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLB6"/>
    <dbReference type="GeneID" id="38779880"/>
    <dbReference type="InParanoid" id="A0A401GLB6"/>
    <dbReference type="OrthoDB" id="2750697at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25219" checksum="453B0717770FE61F" modified="2019-05-08" version="1">MNGWAEVDELHDYHELFFLLGSQFSASLRKLSLKPTAISYDHPVRLLDSTYPSLDPHQLEWLDLDIWGRIQITSVNLRTMALSWPKIIALRITADHDTAVAPSIYTLADLAHHCPHLQKLCLPGVEVITPPPPELKSSPVSGHALKVFTMAGPENESPPFRIEVADPAQVAEFLDTLFPQVRLEFYVEGDWERVIEKQEALQAARRNARARAEKDDRRLLVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLQ7</accession>
    <name>A0A401GLQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dicer-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0501490</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614015.1">
        <property type="nucleotide sequence ID" value="XM_027758214.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLQ7"/>
    <dbReference type="GeneID" id="38780019"/>
    <dbReference type="InParanoid" id="A0A401GLQ7"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="24"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="387"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="16">
        <location>
            <begin position="590"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="13">
        <location>
            <begin position="988"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="13">
        <location>
            <begin position="1187"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1099"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1099"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE83102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1495" mass="169989" checksum="F436C06A5930E02F" modified="2019-05-08" version="1">MADNENIEDEATATVHTRGYQQEMLEESLRNNIVIALDTGAGKTHIAVLRMKLEAERETRKLSWFLAPTVALVEQQRDVIASAIPVSVGIISGEAEPDQWTDYALWRNILDTHRIMVTTPQPLYDALTHGYIDLGRDIGLLVFDEAHHAVRKHPYNMIMKQFYFKLPRRGSDDDSVNRVRPQILGLTASPIYGGNVDKAFSDLEQNLDCVIRSSRLNRDELANHVHRPVFNHVLYSSPTYGWGDLPSRNVHALKSVLSRMNIENDPYVKSLHSRLEKLQPGPERNSVDQKLSKTLSKEDTFTHRGLRDFERAAEEICMELGIWAADWYVAKVVEVAKVAANPHNNYMSAWQEKEKAYLLSALVQVQLEIVSSQPDDIRAACSPKVLSLVQCLLAEEANFQSFDESYSGLIFVTRRDSVLALAEILSRLPEISEKFQIGCLLGSSTSSRRHAFLDITRHMLKNSQSETLRDFKIGDKNLIVSTSVAEEGIDIQACGSVIRFDPPPNVVAWAQSRGRARRRRSSFIMMFENDGGHRPLVQQWEQTELRMQALYLEERAALQAQPNDDDDDDETDDVAYWVESTGAILTLHSATSHLNHFCAVLPNAGYGGHDAVFDLDPPDFPEGWHLNQTQLPPYEGPWGATVTLPRSVPASLRTFSSVRVYRSKRSALRHVAFNAYVELHKAGLLNDNLLPLTSAIEEDKGEEVKKLLEEVEKRASTEKVAIQMDPWLSPAKDDDAWFCSRLTIDGLPELYMLTHKPMPFLHDHEFPFLFVPGKEPLRISVKYQKGFPINAAFVERARRYTRQIFAILCSQRMDPEDTSFTYLFLPIVLSEQEKCWNERRKWMQDRMSAVSELCIFESAERANADTLGKRFSRPNDLTLIRSGEKFNKLLRFIEWTYNDLTEEQEAELLKRYEGFLDVDPTYTPLIMAQPFPRRVNFLLPLFSETEGLGQDRPVLLHPKHVTVELVSGPDVQYAMLLPSVLRWLSNALTVLSMRSELLFGSAVARVPLDLLVEATTAPVSQEATNYQRLETLGDTVLKFIASMQVFADHPLWHQGYLSRRKDHVISNQSLAQAAISKGLYKWIIRDRFAPKTWKPRYSNDSYVPRTPTSPSMPKDSNKKERTQELSTKLLADVVESLIGASYKSGGFDAAIDCARLFDLDLNWKTIPVRIQDILAQTEEHIDPPSQLGIVERMLNYQFTRKTFLIQALTHGSYHGELASMSYERLEFLGDAALDMVVTNYIYDAPGKNYSPGHMHLRKEAVVNAHFLAFICMNTSLEFEGAMPTWTHEGDVALEADRQQIYLYRFLMHSSHRVLEDQSVTFARFEKSGPVIAHALKHDSIYPWAALTSLQAPKFLSDMIESLLGAVYLDSEGSLEAVTKVMRTLGIMDALERIVEGNVDVLHPVSRLQEWADRQDPQQEVEYEMTKTKLEITCTIKVGGEVVASVTELWRSRVSQQQVKFAAAELAIKNLHVRDEITVDVDYDDDWDDLPEEMPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM08</accession>
    <name>A0A401GM08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Structural maintenance of chromosomes protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0502730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614139.1">
        <property type="nucleotide sequence ID" value="XM_027758338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM08"/>
    <dbReference type="FunCoup" id="A0A401GM08">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GM08"/>
    <dbReference type="GeneID" id="38780143"/>
    <dbReference type="InParanoid" id="A0A401GM08"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="110"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="755"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1032"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="883"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="756"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1032"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE83226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130528" checksum="DA1763BDE152897F" modified="2019-05-08" version="1">MPPKRAITIHSDDEGSAPESSPASKRARTQEDSDTGLASRPKRATKGKGKSRQRTEEAVDLVDEEEDAVEQTAPDEDEEKRFEEEHEEEIRENLMSKGKAQGGIAEMGIIESIEMHQFMCHKYLTFQFGPQINFIIGHNGSGKSAVLSALTVALGGKANSTGRGSGLKSFIREGQSVAEVTVCLKNQGEEAYKPKDYGKTIVITRRFTREGSSSYKIKSKEGKVVSTKREELSAICDHMNIQVDNPMNILTQDAARQFLSASQPADKYKFFLRGTQLSQLSEEYQTCLENISQTQKVLKRKSEVIPDLQDALEEATARFREANKAREQRHKADELKKELAWAHVQTKQDELQEKLEEAAKLSRRLPKIREQIAAANKEFEESSQLVQAYEEENHNLGSIGHLHEMRNEINSKLKTNKQKLATMNNEEKEMLRGLKRVNDAIANLDARIQEEVKKDEDASKERRDDLNRRLEEAKVSCDQAERQLQDLKDERQQRGPETEKIKQDIQKLNQEREQLKRSIVECQEQVRMCVERERNKVARFGTNMDRVMADIQRTRWHGNKPVGPFGLFVGVKDPAQWAPIIRVQLGALMSGFAVTDARDRKTLEKLLKGHGNRNPSIVISEVDLFDYSRGEPPEGYLTVLRALEISDEYILRVLINQAHVEGTFLAPTRSDADSVLLQYGRGGTAWSGDLYNVRRFPEGGGQSSVIHALSMGDPRQQLFTGNDATADKQRWQERGMKLEQQYNLLSQQIDQLKQTETQKDREARSLAKQESDMLRRSRGLKDQRDSLQIQVNNDMPVGISGLQDSRADMVKEKEAYESQWQTLDKERKEVNEAQRPLLEEANVIKKQIEEFSELQVGIQNKISVEAVRRLNAQNTATHFSEKLQAEEAKVTTAEDVVKTLQTEFEQWTAKATEYCERFENPRKAEDVQKNLEAVQTALREREKKQGATVEDMTIEVNKKKAALETAKKDLKNMLSLNRALRRSVKVRLAKWHEFRRHIALRCKVYFSYHLSNRGYYGKVLFDHVNGSLQLKVQTDDQTSTQNSREKDPRSLSGGEKSFSTICLLLSLWESIGCPIRCLDEFDVFMDAVNRRISMRMMIDTANSSNNKQYVLITPQDMTNIHVSPSVRVHRMTDPERGQGVLAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN37</accession>
    <name>A0A401GN37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0506810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614539.1">
        <property type="nucleotide sequence ID" value="XM_027758738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN37"/>
    <dbReference type="GeneID" id="38780543"/>
    <dbReference type="InParanoid" id="A0A401GN37"/>
    <dbReference type="OrthoDB" id="2797568at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="814" mass="91840" checksum="4D307F749D50CC6F" modified="2019-05-08" version="1">MLSATPAIAKSYKQVANDAERREANEKNQQAWASEYRGKINEYHGTIDSFINVLVPASEAVCPPMDCSGKFDDVREDCLEPLMYNPLVNGFLALTKDFPVAKSLRFHDNSTHLIPFPYMSWDLHHHRMKPDLITSYPGTTTSLKDPRWKDVALAIEVKPKRSDDPMNVWAKARDDTMRQLVKNGRNLLVGHSGLFAFVFGIFGHQARIFRFDHSSCIVSPRFNYVEQPELFRQFLWNFVNPLCDTRISGDDPTVDTKITRSHLRWVEDVLEPEDVQGSDTGMHRWISAKAVTKEGETVTLELLTVKLLFINPCLFSRSTTVWSAIDKDEINGKQYIIKDSWRQGLRESEMTYYSHIMKTLRDRNEEPFGLAVLRAGADLGDLEDKERMKPNDQIRAPLVPGNPPSDLPDPSSTPLVPSSISMGADDADPLSSPLSSPPRTQTSMAAPDEQDPFNPVVSPPPPAFFDCANQEGHRTLSAFIRSPKHAEDNDRRHMRLIMETLGIPLSDFRRTKRMVEALCDAIKGHQQAYSTGVLHRDVSEGNVYMIDGKPYKGFLGDFDYSSFMPGVLGAHDDSTRPDADENNGLKERTGTYAFMAIELLARRGVIHGAHHDLESFYWLLIWLVLRHTTHDDPEGANQCSLLFFHDNDLICASLKRAWLCREEYLGVPGNVPVTWLLRELTKLCHRGQSTSERPAVLLTYDAVLEKLEMALKMDGWPENDGAIPFKPYVEPQEEGHADPTNATITAAISASNQTAKSKKARSQKASVRFPDNVMAGSSKRKREPEPHDNVDENGVRTSKRIKELSLKRSRSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN46</accession>
    <name>A0A401GN46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0506440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614502.1">
        <property type="nucleotide sequence ID" value="XM_027758701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN46"/>
    <dbReference type="STRING" id="139825.A0A401GN46"/>
    <dbReference type="GeneID" id="38780506"/>
    <dbReference type="InParanoid" id="A0A401GN46"/>
    <dbReference type="OrthoDB" id="2150628at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051667">
        <property type="entry name" value="Archaeal_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096:SF1">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37096">
        <property type="entry name" value="YALI0E33429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="92314" checksum="1FF5FF32E7ACCA27" modified="2019-05-08" version="1">MPSTRRWPRAYRKFLPPAANPPYLPSFNPYPHLLTSSIGVNRSNSDNSGDHPARTSSTPTPVFIDARTGTIFHMQAPTPRSRPRSYYHSGSRRQSLHTAVPATRIQLHWLFRSNIPRRRGMPLQADVNKRNFFGIGEIIGVLANPSETLRSLTDSKRMLEETKRELAEARERAQLTPTHTFSGLPGFFDRPAELKAIERALEGEPSFTILFGASSVGKTALLRQVLTRPTYHVLHFDLRIAGFADLSSLYMSFSQQMEGFFNSIAQDPDMPGYEEFEKEAWGFKHDRLNVERRVANASPNGESAGHSGLGDIKTSDVARLMELFQSSLLRYWNFQPDMSSPSRKSYVDSEGADKASTQGQSKKARSSWRRFFGRRKREEQKKPEIQSVRPMNGDGRGEDAAEEKGKGKERIPPMKKIPVVFIDEAHKLPALIRSVDAMKCLLDAMLVLTKQDRLCHVIHATSDPFYQTWLRQLNVMQHCKIMTIGDYPKADVRRFFRERILPSVPEQLRGGLDFERLYDAFGGKLAHWQDYITDYVNVSGKLEVKQSSHFLQAHALLNLHIIHSSQAPQPSKADGRPGATPIHSNRGSTQAIHQLSPPPSTPGFHIYSPLTANPHIAPSAIPPPNRNSMSADEFQGDFTFLQLLKVMNLMAQPEARPIPYFRLCREIGVRAVDGMVRGRILDLRWTDPITKERIDPRTLSMRIRESMRVRGSVRERESMPMNFGAGSSGTMVNDPEEMMEYEDEMVPMTDEEIMRVQDRMAGANGAQEDEDVVGPKLVPITPIMRFAMREVVQEYYDNDDQTVSEYASLSDVVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNT7</accession>
    <name>A0A401GNT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614796.1">
        <property type="nucleotide sequence ID" value="XM_027758995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNT7"/>
    <dbReference type="FunCoup" id="A0A401GNT7">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNT7"/>
    <dbReference type="GeneID" id="38780800"/>
    <dbReference type="InParanoid" id="A0A401GNT7"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42001" checksum="37A1D8D7D82086D9" modified="2019-05-08" version="1">MFGTLIALGVVSTAYGLYEFYSAFTMWPEEVRADLRAGVKAKRQDNLSLSEKFFQRAWDTAQTLSLSHFGTSPYLKLSGIAISLAEVLEAHERPQPAWDAYVDAIEQFTRLRKQGVPLSGPERMRAVAIASKLGEMAETYQLPLEDEEQWLSWAVSELMKILKEAQPERGADVGGEEPADVPLMLAELEMPPWVSKTTLGAPLEALGNFYARRGKVEYAVPLYLQAINLLVPPSGSNKTSTTEEKCRGAQLMNNLAELTIREAPTPDNRRRAELWARQARGTIERTKAEARGGAEELATCEQALAAVMFNIGSLLEMRGEHEQSRELFKESLDQANRIKMREGTMAARVALRRLERTSIERQIGGNGTNAPSDSPQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP08</accession>
    <name>A0A401GP08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614813.1">
        <property type="nucleotide sequence ID" value="XM_027759012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP08"/>
    <dbReference type="GeneID" id="38780817"/>
    <dbReference type="InParanoid" id="A0A401GP08"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="274" mass="29679" checksum="48D200C131E87042" modified="2019-05-08" version="1">MPTSEKHTLRRMEGVSNLRRAATLPHTANSNTSASQLQALLTRPASQELLPTPPPEYSQEPPIQMPQPRRLSLPPLFFVEQAPLSVTVRPLPIPPRGAPHMIVRPLPQPPSGTANATVQPLPSQPTIASDYTRLYTALQNHEEMVGADSAHDQLRSPPPYQVIPPALVSSAPRSLRPLPRPPQQSGPPAASVAPACSVSSMPRPLRPLPKPPQQSGPPVASNDPAEGGSRTVLGNVSGLDVQVELFPGRSATTRSKRKEEDEYQPCLYDEQQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPF4</accession>
    <name>A0A401GPF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615011.1">
        <property type="nucleotide sequence ID" value="XM_027759210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPF4"/>
    <dbReference type="STRING" id="139825.A0A401GPF4"/>
    <dbReference type="GeneID" id="38781015"/>
    <dbReference type="InParanoid" id="A0A401GPF4"/>
    <dbReference type="OrthoDB" id="3258904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53371" checksum="765D7FAAD86BF390" modified="2019-05-08" version="1">MRRPENVSFLPAQVDAALASRPLTATISPLYLFLSDLVLFFGNAFYLPGIVFPLAPWPSGHLDELYPSLANLSAISVHLFLVCLQLGFLLSLPLGLFFVGAVWLLYCAAVLFAVFLVCLPLNGGRNGQKVLSDRRILHGCDPKDRESWVFINGVAVGKHWLQSNLDRLSLTFLRPITGVHNITAGIVFDVLECLIQRDFSYHPRDVRQTYAFLKNALLDPHKDKVVLLAHSQGGIIASMALDWLYAELPLSALRKLEVYTFGCAANHFNNPFRAARPGDAATDAERDDPLRARVNPDSPLAGSARAILGAQPGAAASTAPFDDARAVAHVEHYANECDFVARWGVLHYAARAERFAGRVFTRRGASGHQLNQHYLDAMFPLDDGRAAVREYNEFVDAECEVDEALVMRREEPEVAEMDRILGSDGDGEGKETVEVAMGDGKGRVGPLGKMYRKATRARARAAQGARVRDLSRLWAYRNGMSPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ04</accession>
    <name>A0A401GQ04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1348-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615195.1">
        <property type="nucleotide sequence ID" value="XM_027759394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ04"/>
    <dbReference type="STRING" id="139825.A0A401GQ04"/>
    <dbReference type="GeneID" id="38781199"/>
    <dbReference type="InParanoid" id="A0A401GQ04"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="18334" checksum="70273519FBFA10F4" modified="2019-05-08" version="1">MSSIKPPFTAETARQKVKVAQNLWNTRDPARVALAYTPDTIWRNRAEFMHGREEVVKFLTKKWEKEDGYVLRKELFAFLDNKIAVQFWYEWYESKDGQKQWYRTYGLEDWTFAPDGLMQKRQMSGNDVPLTEEERWFKPGVDIEAVELTDKHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQB6</accession>
    <name>A0A401GQB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0603950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615329.1">
        <property type="nucleotide sequence ID" value="XM_027759528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQB6"/>
    <dbReference type="STRING" id="139825.A0A401GQB6"/>
    <dbReference type="GeneID" id="38781333"/>
    <dbReference type="InParanoid" id="A0A401GQB6"/>
    <dbReference type="OrthoDB" id="3269067at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="424" mass="46692" checksum="DC97737FC7C3EA9A" modified="2019-05-08" version="1">MPPSPSTILTDALSSLSKATSLALATAEEQARGELERADAEVAEACEERDNALKTLRTLELGEKDWQRRAEGWKAAVDKSELTIKHQAETITHLRAEVQQWKTQLTRLEEASRQELLDWKEQYLLVEEERCRLSSRIDELVAEQLAWNTQANATLTPKTHPVDLAEPSAVSTTTKRSSTSSNTATGPYLTRKGTTPRIPPDTAPRKSRTAVTPSKPPNHDPMSTQPSKRKLPADSASTASKATPRAITRDSGVAFVPRQQILRRHVRAVIEVPVKEEEDSEEQGFASDGSYASGSAYEPEESTTPITSRTTRPQRMSVRKGVPRSWGEDEGEESDYGSNQVRGRLNHRPRRRMPEDDDIDELAMSAEDDATGCYVAQPVASSTTKARGNQRNTAPAQSSAKKRKLDNGVGTAARSATAKVSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQU9</accession>
    <name>A0A401GQU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Delta(12) fatty acid desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0605720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615506.1">
        <property type="nucleotide sequence ID" value="XM_027759705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQU9"/>
    <dbReference type="STRING" id="139825.A0A401GQU9"/>
    <dbReference type="GeneID" id="38781510"/>
    <dbReference type="InParanoid" id="A0A401GQU9"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="7">
        <location>
            <begin position="97"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="421" mass="48710" checksum="E0014E462CA3C81C" modified="2019-05-08" version="1">MTSSTHSTEVAGARQSYAEGALPTFTPIPWSLNEIRAAIPQHLFTRQTWRVLLYVARDLIMAGFFLRSALRIDSFYGGEHVVEHLTVVGAQIARLMTWLLYWLLQGLIFTGIWVIGHECGHTALSGNKHICNIVGYIAHTILLTPYFSWKITHHRHHIAHASMERDQLFVPRTRSDLGIPSKGQQLDYEDYFGDTPLYALTVLIVQQLLAFPVCLACNISGQKNYPRWTNHFNPNCVLFMKNQRSLIIISDLGILFMMYILKRTYEAWGATTTFKVYGVPWFCVSHWLAMITYLHHTDPELPHYRRAQWNFQRGAAATMDRNFLGYIGRFFFHDVAHFHVVHHFFPKIPFYHAEEATRYLQAFIGEHYRYSDKPVFEAFWHNVNECKFIEDEARSAQGQSCIRGTGGRPERAGMYTSVVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRH7</accession>
    <name>A0A401GRH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0603020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615237.1">
        <property type="nucleotide sequence ID" value="XM_027759436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRH7"/>
    <dbReference type="GeneID" id="38781241"/>
    <dbReference type="InParanoid" id="A0A401GRH7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="500" mass="54859" checksum="66CC13EE477191EE" modified="2019-05-08" version="1">MEAWWYKLGDPWEKVYTVSESTLVQLEQLHVRITNLTSWLHERTDQNLDVVLEELQEVTRQLQSELGSTLQNDNNNTNGSLGTSRASTGILAHCATLFNNPALMVNSNGFQDMNAHGFECADYAQRPGPVYSYNAFPSEPNALGVATENANAHGFECADMVQHPWPASLYDTLLCESNVPTNAMETHGHVNAAAIVEGYEILPLIERAALENISTLTDFVDAYALTIAPDTHAQENYALESVRGTQQEQEDAIVAGAEHATIAQHAPPVLHLETVLNDVLTGTPFHFIDDSVYNTCVDRANAPSSLIDTRPTAFIFLSHLDLADIPATPPLSRSPSPEYTPSSPVYIPSSPVLSSPLSPPSSACTCTREADCHAVRACNRPLPLPHSTLSVIHDPDTHLCRPMHPPGSHARRASPDSYDGDDDLLGLVSVSHGNDSSDSELDMDLEDDTDDDDNHLQSECEREDLMRERVEEILVEVMRNITEEVVEYVSPALSAHSFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRI6</accession>
    <name>A0A401GRI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615692.1">
        <property type="nucleotide sequence ID" value="XM_027759891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRI6"/>
    <dbReference type="GeneID" id="38781696"/>
    <dbReference type="InParanoid" id="A0A401GRI6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15432" checksum="AA53F1E8EFA84925" modified="2019-05-08" version="1">MSRSPRRTLRTHVFSSARQADVVVALANGVGVGAENVFEDSIRSSRKTLGKTRRASPVDGGNVAERNLPGDGLEDRDADELSDDEILEVPRVAHNPLAADFVEEEYYEGSRYATDRAASYSTEATRTQSNYGMALRSHDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRJ0</accession>
    <name>A0A401GRJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615739.1">
        <property type="nucleotide sequence ID" value="XM_027759938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRJ0"/>
    <dbReference type="GeneID" id="38781743"/>
    <dbReference type="InParanoid" id="A0A401GRJ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="218" mass="23500" checksum="0DC2E72759AF21E5" modified="2019-05-08" version="1">MWHDGPRPSPELVWKPPRVSSLGEWIEAETKPKSTFASTVCGTPSFVTDSGWFSAALADDEPEVAENERVDTGDFNGLTLQDFLGLQRRSSIHGHATESSDRLTSAGSDVSRPGNATLNGTLLQDTMGRFPTSTSSMLRSPSHSSLDIEFIDWDRATSTVSLPGNATLDGTLFRGAMGRFPTSTSSMIRSPCHSSLDIDFIDWDRVTSAGSSVSRPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRP5</accession>
    <name>A0A401GRP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615808.1">
        <property type="nucleotide sequence ID" value="XM_027760007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRP5"/>
    <dbReference type="STRING" id="139825.A0A401GRP5"/>
    <dbReference type="GeneID" id="38781812"/>
    <dbReference type="InParanoid" id="A0A401GRP5"/>
    <dbReference type="OrthoDB" id="3515175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="597" mass="66272" checksum="6ED5C7BC49D6E110" modified="2019-05-08" version="1">MGQRHQAFAIARVRPHGSPPHSPPKYRCIAAYHHQWCYGRLPLLATYRLLTLVRQKENAEIVRAEIRNIDGKYGHYQEQPEIINVPCPFTAYLLGVSWDVDLTVAEDAYSSGVTFHHSLLRASMGSWDGDNNDGISVIDVTDPGNPAYCFALSTSTPLSGEQYMRAYYPVPTQSEDPEYSRQIEEIVLKIIALLDGEKMVTLDMLAEAWPDEYQSEAIERPTGDITDSTSTSTEPAEEAPIPSLAALTFPQAFDYALEKGDTIENILWLPGKLADTKSLLIAKSPFPDNAVQLLVKVLTEMKETTSVDLTDFALSSEQAVRVASQLPGLESLNLSFNAQITTDTVREILTAAPGLKRLVLMGCTSVTPEDLYDLLRKEPQLFYKLEALMHPALLCAAEPPPFPIAFTFMTNNETIRSMCGCSLALFTPAGVVDALAEVLRSIWSTPFSISSVDAGLLFEAVPTSRPRAPDVPWGARSVVAVPALSVNVFRAAEPGWAFLFQTNMFKQNKNWCFLRLVPTARKSEEAAQDLPWVAGGWEIHDVRSFVRITTAEGRPAPSEDAVQELEELLRHTPESGPQLHLMDREVLNRFMQSRPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS91</accession>
    <name>A0A401GS91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0702150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615942.1">
        <property type="nucleotide sequence ID" value="XM_027760141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS91"/>
    <dbReference type="FunCoup" id="A0A401GS91">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS91"/>
    <dbReference type="GeneID" id="38781946"/>
    <dbReference type="InParanoid" id="A0A401GS91"/>
    <dbReference type="OrthoDB" id="162638at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.60:FF:000001">
        <property type="entry name" value="50S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_bL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8573" checksum="0D533776E0518B90" modified="2019-05-08" version="1">MLSTSAVLQYPKLKTHQGAKKRWRSLPSGLFKRPKAGHQHLNTRKSSARKNALSQTAYSHGSQTATLNKLLPYGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT08</accession>
    <name>A0A401GT08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ROT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein rot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0705330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616259.1">
        <property type="nucleotide sequence ID" value="XM_027760458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT08"/>
    <dbReference type="FunCoup" id="A0A401GT08">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GT08"/>
    <dbReference type="GeneID" id="38782263"/>
    <dbReference type="InParanoid" id="A0A401GT08"/>
    <dbReference type="OrthoDB" id="5327821at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019045782" description="Protein ROT1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE85346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="232" mass="24608" checksum="68106AFDCABEFD8B" modified="2019-05-08" version="1">MFLTPLLALLLAVPALAQDIILDAGHNVTTLSGTWASGSGNVVTGPQFANPANQTFNYPSTTGVSYSFTDDGFYEIARYRFNGNGTQPTCIVGVINWCHGEYVLAPNGSILMTPFGDGFQQIQDPCGAVSKFIQSYNDTETYQSWSIYQDPALGYQLQLFQFDGTPMPQQSLVSTTPNMLPTQALRNVSSGSLTVQADLAVNAGDRIRALGPRSIGGLVSAVAAVGIASAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT11</accession>
    <name>A0A401GT11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flap endonuclease GEN 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0705680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616294.1">
        <property type="nucleotide sequence ID" value="XM_027760493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT11"/>
    <dbReference type="STRING" id="139825.A0A401GT11"/>
    <dbReference type="GeneID" id="38782298"/>
    <dbReference type="InParanoid" id="A0A401GT11"/>
    <dbReference type="OrthoDB" id="3005703at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="1">
        <location>
            <begin position="117"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="455" mass="50710" checksum="7E1810EEDA0461AD" modified="2019-05-08" version="1">MGVNGLWELLKPTREETSLKLLALRDRFEGRPGERLYRLGIDTSIWFHQLQEQFVARHANSSENLELRSLLHRLARLLKLPVRPLFVFDGPGRPAHKCSRKVVGMHWMVGNTQKLLDAFGYEWRMAPGEAEAELAKLNQLGIVDAILTDDSDALIFGARTVIRNYKVDAEDENGLRRCGPQTALAIMRYGLGESLCDAAMVLGNNKTELSAFLSGWRDRLRSILSTDPDNHLGHHHIALSNSVPDLFPDVAVLRAYLSPSTSANIPHLPAHPLPVDLAKLSTFCELHFGWRTKSGIIKHVREWLWPGMALKLLVAEAVAYDRRHQKQGAHSTLAAPPLEVWLQPDHSTDQDNVRVIAIDCSSADIAISNLFGVRLSPHPSGTQQLNYSARPLKLWVPSTIVHHARACSCGVDPSTFSDVINLTTSDDDDDDVEQQEVISLIMDDPVVIDLTIDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTD0</accession>
    <name>A0A401GTD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase component PIG-T homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0706690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616395.1">
        <property type="nucleotide sequence ID" value="XM_027760594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTD0"/>
    <dbReference type="FunCoup" id="A0A401GTD0">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTD0"/>
    <dbReference type="GeneID" id="38782399"/>
    <dbReference type="InParanoid" id="A0A401GTD0"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019517820" evidence="2">
        <location>
            <begin position="23"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="552" mass="61400" checksum="4379282BA299EE7E" modified="2019-05-08" version="1">MHIGWSTNLSFFLSLFFSQVLATSEQFDEELTLRPLRDGKLATRFAFTTLLKGATPRNPESLASDDESQHYTLFPLALGQILREYAVTELHLSLNAGDWNYDRWGYPDEPGVGTGAELWVWMGDGAPVSVDERWQGLRNALAGLFCASLGSLDEQRTTSPTLSFQPEGSLPDWKAPHQLRHATLPSEHVCTENLTPFLKLLPCKSLSGIARLLNPHRLFDADWHGLGVNVRYHQNAGVEVRLTFQAVFDPVRLSPNKRRDWSLDSIFDRTIDRACPVAHSSEVRVELSGSYTLSPDPSVIIEDLAVFVVKDTQDALDIAMRWPGEATFSYPLFAAAEPLTHMSVQRTLKGSSQSDARLSLVITNNLPVQVQTGYLETMPWLAQFYIHTLRVRSDGVSRDDLVTIISYAAPVPHARPTLFQAALTLPPKSTLEVTMDVLKPFLRYTEHPPDAQRGWDLPPAVFVPFSFGNLSEAGLNVSAAALTTLRRRPRRIYTSTLLVDLATPDFSMPYNVIIMSCTLIALIFGSVFNLLTRKFVVVSIENESGAGKSDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUP1</accession>
    <name>A0A401GUP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616860.1">
        <property type="nucleotide sequence ID" value="XM_027761059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUP1"/>
    <dbReference type="STRING" id="139825.A0A401GUP1"/>
    <dbReference type="GeneID" id="38782864"/>
    <dbReference type="InParanoid" id="A0A401GUP1"/>
    <dbReference type="OrthoDB" id="2739487at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="292" mass="32943" checksum="82203BA5E44B230E" modified="2019-05-08" version="1">MAVARYPFNKPTADLILRSSDRVLFRTHKTILAEASPFLARIIPHSAAAHGASVNDLPVLEIEAQSRTVENLLTICYPVPNPLLASSREISDVLHAAAKYDVSYAFVVCKQALLHPDLVRDDPLGVYAVACMHRLEGVARAAARHTLRFPYLLRPSEAMNALPAPERSWLLWYRDGCRQVAIRTVHFWYSSRIERAKNLTFECEECRDLDIPPEENLIEFSVDKEYFLAHTLALMDKTPCGEVILNDAELGSWSFVDTQEISCCGCREGIALAMRRFRADLAREVDRAIFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV55</accession>
    <name>A0A401GV55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0806000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616989.1">
        <property type="nucleotide sequence ID" value="XM_027761188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV55"/>
    <dbReference type="GeneID" id="38782993"/>
    <dbReference type="InParanoid" id="A0A401GV55"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="331" mass="36451" checksum="6CE585244FC980FC" modified="2019-05-08" version="1">MPLSGAQSVIDDYFSETSPTPLPHPRDFRGVPAHDIRDNLRAHLRFSQRIGTIGDLEDFIVGIVDSINPIRSRATTPYSASTRTALDSWSSRFVQGMSGKELYLQALTVLDDSHVQYALRIIHSQQAAKSEIISMQHAIAGARRYTERMETLALSMGDRIQPQEETLALMFAQTNTYQRLVELDADATQPFLPTFLTDMPLETPQEGTPPIPPPRPSHLDSMTVPTPQPSNLFEGTSTSSAPAATHDGVSIARPLHPNTPPDYVSEWNFSDNPNHHAKGLSPMTTENAVQTEMPEHSDQSSQTLVDPGESEPGRNISPFPPAFSTALIRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV88</accession>
    <name>A0A401GV88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0806360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617025.1">
        <property type="nucleotide sequence ID" value="XM_027761224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV88"/>
    <dbReference type="GeneID" id="38783029"/>
    <dbReference type="InParanoid" id="A0A401GV88"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="157"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="704" mass="79683" checksum="E0EA381A9A1E8EFB" modified="2019-05-08" version="1">MSSSRSRAPSPSTLPGEAGLSLPPTPHSVTSDWTPLAGKENAERENLRRSDDDNELHADKAEGFVLGPVPVEDFLDFLPAKHAARRPSTSLMWPPGWAALAIGSDNEAAAKYAGELFIDVQSSDHDEFFRDPKPSADRARHKFVLSQPDTEKTNRMKARQAMGRTVRWATNAPMHQHRAHYFSVSVDGLRARLLRWDMSGVVASESFGLREKPEVLCEFLWRFSHASTVDRGYDPTVERASGGEERLFRQLVSCHVREQLDLKLVDVPGGEVKDKVRAEYEAQRALLEKTVALHYEAGRVAALTVCAEDGRLKRCLVSRPIATNFSMRQGAMRGYWAVMDGRVGFLKDTWRQYILEPEGRILKELEAHVVKNVPHVEHDGDVPKVMYSDGMLTRFSAMANFERTTRSKAGQQQPFGFPLQTLQGTKELLNAAHDAFQALIAAHAKARRIHRDISAGNIMLYRKPYQDHWTGYLIDWELSSKVQEDGQATDKYIVGTRMFLSQRLEVRSQRRHMLQDDMEALLYVVAYCGLHWLQHPAHCKDTKQVVQALLHNRREVRVGDVPEVTHTTFQTMEPGTGQLDVKENRTYIDAANFNADLRDWLSRSMDSNHPRDPNEATQWDTPERWNDYWTEFLGRQLPEDDRIRKQDSSSMRPKSAVKAISHCAGSIPTNGRHRNAEDGRTDDGRTNGVLGNGKPIKRLKRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX03</accession>
    <name>A0A401GX03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617207.1">
        <property type="nucleotide sequence ID" value="XM_027761406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX03"/>
    <dbReference type="GeneID" id="38783211"/>
    <dbReference type="InParanoid" id="A0A401GX03"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="151" mass="17541" checksum="E53A6453539D2EF3" modified="2019-05-08" version="1">MFDNIVDELQALSASQLEEGNTESSTQVYIWLCKIAQPFLRSRFLKQLCDDMTFSHWERRMRAYRLKRCLDQVCQYVGDITLLMQQANRMFPDGKTPCRWIKDSFVGSGEGKSSISNDYLEVLRHGFQLESTLSDATVRALAEWFPDMHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX25</accession>
    <name>A0A401GX25_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1000090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617680.1">
        <property type="nucleotide sequence ID" value="XM_027761879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX25"/>
    <dbReference type="GeneID" id="38783684"/>
    <dbReference type="InParanoid" id="A0A401GX25"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39482" checksum="BE4679E12ABCA62C" modified="2019-05-08" version="1">MTHAAANVPFYARCTPEEVQHHAKSTAEGLYSLLPIEIFWRDRQVYLEQHGYLLRPRFRPGWSPSWLGTDIAPNFCEDSICMLARHVMDAVKEDGGELVSLKSVERDGNEVRIAQYLFKSDARSDPLNHCVPVVDVLQDPLDPKLSILIMLYLRPFNDPEFGTIGEAVEFMRQTLEGHHPVRIETSRDGTRTLSPLSRSDHPVRYYYIDFGISSYIEKGTSPYVLGRRGRDKELPELSSEVPYNAFKADLFILGNLYKKEFLQTYLDLEFLQPLVQVMTAHQPDQRPTAEGAFSIFEAIRHALDGSLLRWRLRRKEETAPERVVYDTVAAAREGIYRLRHLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXQ0</accession>
    <name>A0A401GXQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspyridones efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1001830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617852.1">
        <property type="nucleotide sequence ID" value="XM_027762051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXQ0"/>
    <dbReference type="GeneID" id="38783856"/>
    <dbReference type="InParanoid" id="A0A401GXQ0"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="345" mass="37413" checksum="7EB361E585578588" modified="2019-05-08" version="1">MIMTLTSIITGKLGDRYGYKPFLAVGGLLWTVSMLCSAFCTKIWQLFLVQGVLQGIACALVFPLIVAVPSQWFSKYRGLATGVVVAGCSFGGAVASLILYAMLQPLGMRKTFAIYSVIDAVFLTMAFFMIKERRRPQAQRQHIVWFDRTFFTDPVFWSLGLCFLFTTFGYLTPIFYLPMYTTQMIPSADVLLSSLPVTVLNLSAACGRTLIGFVADRVGPVNALFVAVLLSGLTQLLIWNFVTTYAGIMSFAVLYGFFCGSFISLSPAVGAQLYGSGRLAGLSGLLIFFNLPGNAAGAPTGGAILNATGGSWRAVACWSGAMQIVGAIILCYARFKRQPKLFSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXZ0</accession>
    <name>A0A401GXZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1003090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617975.1">
        <property type="nucleotide sequence ID" value="XM_027762174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXZ0"/>
    <dbReference type="GeneID" id="38783979"/>
    <dbReference type="InParanoid" id="A0A401GXZ0"/>
    <dbReference type="OrthoDB" id="193860at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019388086" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="61" mass="6584" checksum="292694931AE0B3D5" modified="2019-05-08" version="1">MVVMALVLGMPASTCLSEVARADVKAAVEALQEVGLVHGDLHRENVIVREDGHAVLVDFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY29</accession>
    <name>A0A401GY29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Karyogamy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1003480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618014.1">
        <property type="nucleotide sequence ID" value="XM_027762213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY29"/>
    <dbReference type="STRING" id="139825.A0A401GY29"/>
    <dbReference type="GeneID" id="38784018"/>
    <dbReference type="InParanoid" id="A0A401GY29"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="587" mass="63028" checksum="00BDFEFE047C1890" modified="2019-05-08" version="1">MPSPPRSPAPSPTSSPTLPTKPRPNRPDLPPAKRARVARYPNYVPEEETIRNDYSQRYVDGGEWPQNWVLGAHPEHRFEEYPKQQRLLALKKASVAAHTLPPTYLSFSELSSLHPSKFDAILIDPPFSSSFTWDDLQELPIPALAADPSFVLMWVGSGAGEGLERGREVMAKWGFRRCEDIVWVKTNNTSNRGPGTDPPTTSLLTRTKQHCLMGIRGTVRRSTDSWFVHCNVDTDVMIWEGDASDPTLKPPEMYTLIENFCLGLRRLEIFGRARTTRRGWVTALAEGEEERIAHKMEVEVSVDPQETAVKWDRETWEARIKELANGGKAVVPMTPEIDALRPKSPVRGGPANPSMGMGAGAAPSATPMAMGMSVAVPMGSNTGSGNRSGFNSSNRMMGQPLMGMNTLAGAADMGMMWPDMGMNVNMVGMNGMNGMNGMNGMNGMNGMNGMNGMNGMNGMGGMNMGNMQGMNTMGLGMPVNQQAMGFAQGGGGFSGFEGGQMQQVPGAMGMVNGMGAGMGWMGNGDGQFVDTVGGMWDGGMGEGMMGMNGMGNMGMAVNMGMNPGMNSNMGMSMGMGQWGGDGFDGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYI9</accession>
    <name>A0A401GYI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1003710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618037.1">
        <property type="nucleotide sequence ID" value="XM_027762236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYI9"/>
    <dbReference type="GeneID" id="38784041"/>
    <dbReference type="InParanoid" id="A0A401GYI9"/>
    <dbReference type="OrthoDB" id="2631524at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="921" mass="103672" checksum="0FC86FB77B9685C0" modified="2019-05-08" version="1">MPPVWLARWKTRGSMELRHYQVPLAVKEYVVNQIKQVLREKGVKHWSKWVREDLRNSTNDVRSNRKRQLVETYPGLLPGHYRTALESEAWLPIYILTATIPHSDLKDTPFDTNLELCIVTWRHQSGLVGITFYNNHLPETTHPSHFIVDGATTELSNKLHPDSGGVGFIHATQFLQEELDRHLTELEKTEKPHIEAENTGICFRIGHQLGMLNWCKNEGVANQLGAKVESLVPSSLEGILASGDTDSSKGRRIHENRVVITYNRRFALGLSVKATGVDKATEPSHEIPLIKADEVVITILGLPSKLTPEHIFSGVFGVMRQPRTWKIQNWTPHSPTIHFFKPSEVSPSLSRTPDFHEPPFYHRDQLILSGPPLNKLGINYVGDLLLTGDRTIVITAGPLFDEYKRHLSAAVDLAFRTMPELAVELAVDILTDHGNHDGTISRVLTPADTEGKDAYRRAFTAAWRRLDPSLSDDEQLFPVSGAEAALVQELGKTGRPVHPHVKTILARSGAYPDIRLHAESLLLQARSCSIYVPGVDRLRRALATLLPGVTENQLAVRQFNHSQPTIVWDMVTEVFVMGVPAPCENHGDGGCVCWVGPYLADAVASWENRNAGAEMLSKAAMYRVYLNSMEGVHTDDMQEPSNSKNEEVNGNTSPPPQPAVNDEDEDDNELGYITVVSHATTPMQATLRAYGTPRSISPRRVLLTPASPDRRTSSVPALVAAATSSQSPRRTPALEAPPPKTNDTGSTSHHPPTEDNCDTIEDLWQDMKERIEKFTHARLDKERRSAQEKENAVIEQVTHLQAVSDTHERERREHLQALETKGKELMECDLLLQRKDETIRDRDARIAQQKQSLKSQARRIRKLEDNVNKLENRERVRAQKLQTELESMKRRISVAFSEHEEEEYEEKDPPEEPPSKKLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYK0</accession>
    <name>A0A401GYK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1004810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618147.1">
        <property type="nucleotide sequence ID" value="XM_027762346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYK0"/>
    <dbReference type="GeneID" id="38784151"/>
    <dbReference type="InParanoid" id="A0A401GYK0"/>
    <dbReference type="OrthoDB" id="3197992at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="72" mass="8400" checksum="5CE6B96F194ADD28" modified="2019-05-08" version="1">MCEHEIVGDYHRGCQHFHGRYYTGERTDCNSEKCKTSQAHKHLPTQRCNCPAVVTDRHRVQNMIHAPHPDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZJ2</accession>
    <name>A0A401GZJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1102720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618508.1">
        <property type="nucleotide sequence ID" value="XM_027762707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZJ2"/>
    <dbReference type="GeneID" id="38784512"/>
    <dbReference type="InParanoid" id="A0A401GZJ2"/>
    <dbReference type="OrthoDB" id="2750554at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="320" mass="35183" checksum="30977C0F119B9F5C" modified="2019-05-08" version="1">MAKRTQPNSLSSRTSVKSHVSRRAAKVTETLKAGVKTVARPLKRLRKSISSSNLSCATSRALARSSEPDTVDAIELPSDSRSIEIIGGSAMMPAPSDARSIHSAGSHGSQSALDEESDEQELAHLQATWRSPVYAFFKSNVSVQYKNGHKCHFFTCATRKCRNVLGGVRRYQDSKDKASTSNLKSHIIHCFGAAAVEAAIKGENAPRNDSIFAVFARQGQQPVTVSHRTHSNPEVRAHLVKWITECNRPAHLISDREFQELMTAGHPGLLLPTPMTLQRDVKASFQRCRERIGTLLREHPGHLNFATDAWTSPNHCAFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZX4</accession>
    <name>A0A401GZX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1103770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618613.1">
        <property type="nucleotide sequence ID" value="XM_027762812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZX4"/>
    <dbReference type="STRING" id="139825.A0A401GZX4"/>
    <dbReference type="GeneID" id="38784617"/>
    <dbReference type="InParanoid" id="A0A401GZX4"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="89"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="853" mass="93768" checksum="76B40EEC6DA0B591" modified="2019-05-08" version="1">MSSRPHSSDGRAPRLNAVPSIQDSLPEFHFTSPSEPVLLSIPHPDSFTPLCPSARTSYTRVDVSATDDALGVDDDLVHDHEQAAPHPQVAVTFLLVSGRRRTMSFDPETTVGRVKELAWNAWPNEWQDERPPAPSFLRILYLGKILQDDDTLTQLSFPTWPPSSDAAYLSTSPTSQPPPATIVHLSIRAYAPHGADDAPKKKRRHTVRGPVRSVLSRCFVLSKCHISRSVYASPIGRSLPSARIARSVPRPFLFSPSCGPATPAPTSRHGPLHDAYHYPIYHTRRNTTPLSCSPPICAAVHAAPYPSSAYPRPPPFLSGTRPAAPYFPTRSCTSPSGLARSPRTRMHDYSDLFSLSQFGYALYYTHTQIHSFEVSPPCASAHSSKQSSGSRCFQVSSTEHPPSPPPRTRTGPRAIGMGRKNAPQPMRIVSCAPATTAATIPQKRMFDSAEGGRSADQPSASTVINVGNINGERRDLCSVPLSTTSRLVQSTFVHYTAPEPAPASSLLNDPKLLVMSRHVSAEPSGSSQRECSTLTPPQVPCTNMLPPAVSISVPLNGPLDVHHALSLLEAESHAARVKRVRVDQDDKQTGRSYSRHVENYAAWWAEFDMAHCEQQPNLPPMPTFPVTALKASFFLDHELTREKRRRGGTEVIAGSTVGKSHIAQVISALENWRCNNAYLYKNDPDAQMTLRSDLRIRNIETLSKHNEPKRIEKAQALKAVGSSADTYTQEELVRCSRWCLTDFLGVQYVFVGIRDRAMLLLSATTAFCGNSSRILQWSDLFMSSIPMEDVQPSYRVPVLAALADNAKHNQEGRLDEHGTIRHRNVRVCPVGALAMLFFIVFHVLAPAQGLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZZ2</accession>
    <name>A0A401GZZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1103760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618612.1">
        <property type="nucleotide sequence ID" value="XM_027762811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZZ2"/>
    <dbReference type="STRING" id="139825.A0A401GZZ2"/>
    <dbReference type="GeneID" id="38784616"/>
    <dbReference type="InParanoid" id="A0A401GZZ2"/>
    <dbReference type="OrthoDB" id="2663544at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="2">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="1">
        <location>
            <begin position="365"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52959" checksum="A3D11915454AEB97" modified="2019-05-08" version="1">MNYDNHRDRVKLMHMKNNIAIAKVTHAGRSYAAQSAQAYGVTESGTKAMGGWKENGAFRQCYERTFPVDALLGAANFNGRKPEMYSLPRDMLEPPQEVLSQLFPWVEWEQAALEERARADTRAQDLSLHQFLRVLIWFRRVLLQDAAILCSMEVEEHARHAYRNLPEHLVGSLRGATTTVLLEQQRQYDENSRSLADMSDCMLKMEGLLESFVNSKSRSSCRGRQKQELQATSMTAVVQPINFPLVPPMAPAPVPNITINLAGLPLDVRTGPVEEASQLPSDGIAFRVDAQPSHSAAASSSAHVLTASLQPLGGALHAPNESADPQVVKRVALVQLYGQEVFGRHEPWIWMHGELVPHYRYQPVVTISDVWTEWIVGLNGHISVHELTEKWENRWCHNNTGLKTEGGRQKKIVDLINGLMKKPRWSVNLALLFLKEKYKPRYKVRSFADYLMKDGRAGRDEVVSAAMSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0J0</accession>
    <name>A0A401H0J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1201490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618836.1">
        <property type="nucleotide sequence ID" value="XM_027763035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0J0"/>
    <dbReference type="GeneID" id="38784840"/>
    <dbReference type="InParanoid" id="A0A401H0J0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="5341" checksum="8B12B467FC762FA6" modified="2019-05-08" version="1">MLVIEQREGAPSGAPSQIDSHNQRAVGEATARSDEVSLIVVDPVVAIGTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0M4</accession>
    <name>A0A401H0M4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor IWS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1201940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618881.1">
        <property type="nucleotide sequence ID" value="XM_027763080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0M4"/>
    <dbReference type="FunCoup" id="A0A401H0M4">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0M4"/>
    <dbReference type="GeneID" id="38784885"/>
    <dbReference type="InParanoid" id="A0A401H0M4"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="370" mass="42196" checksum="15F6ECD378E32A1B" modified="2019-05-08" version="1">MPAQNDLERDIFGSDSELSDFDDDIPQEQPKGRESPVAREEDESSGDSADEYVQEKLAPVVKKRRGRRAREEGERKAPTRKRKRRSQPEEIDLSQLPPEQASKLKLDMQIEAILKTKRVKSKRKKKDDEDVLDRYADEEVSRLREAMLAAAADDEQANKEKLPATSKLRLLPQVVEVLRKTSLAQSIIDNNLLEGVRKWLEPLPDKSLPALDIQKDFFPILKKMEFIDTNVLKESRLGRVVIFYTKCKRVTPDIARLANDLVSTWSRPIIKRSASYRDRVIPTAQTGEGEGARAGERLNAILARAKESEKNRVRKNAVMIPQRELGSYTVAPRSNAGISKSNFSVDVDIERRKKNAERLRTLTRKITTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1M1</accession>
    <name>A0A401H1M1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1301520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619250.1">
        <property type="nucleotide sequence ID" value="XM_027763449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1M1"/>
    <dbReference type="STRING" id="139825.A0A401H1M1"/>
    <dbReference type="GeneID" id="38785254"/>
    <dbReference type="InParanoid" id="A0A401H1M1"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019312186" evidence="6">
        <location>
            <begin position="23"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="57"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="569" mass="60804" checksum="15A0C7D49A3BBAD5" modified="2019-05-08" version="1">MFVVPLTLLSLCSCFAAIYAAADHNPIFKNTTAVVTVNTTNESQLGFTNSWGLIGEYTATVYIQGQPFQVIIDTGSSDLWIYNSQNLTLDGLIPTGHSRSDTYDDGTYIDGPIVLANISLGQYTVQAQAFINSESAAAEFGSSADGILGVSSPFVSPILEELYSNSPDNGWPFLSNLFNNNPDMEPYITLYLTRSSVGVVDGGALTISEIVTNFEAVLEAPPLPVYSDNAFSTFMDGVYLDGKFLTGNSFGPNGTGVNANPGPNQTIVLLDSGTSLMIAPPYYVDGIYKDIPGAQWIPSMKTYSVPCSTKLNISMVFGESIYAVDPLDSTHVDVSDDGSFTCIGAISYSSASGGVDFILGSSFLRNVYTLFHWGNWTENRTNQPYMQLLSLTDPDKAWANFDTLNLERIGQIQQQQIQDNQNYTYPKTVSQSVTYSLTSPSLSATHSAGASSTSGPSASTLSPSTASTTTPAAAAKLDAALAEASGGVSSSSTVDLGGLTRNSYIIMGLIAGVLVLLLGVLSKLVSDGRNQQYRAVPNVVRPPMHFSDKPYEPESETFVTPYDDPARPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2L2</accession>
    <name>A0A401H2L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1400720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619580.1">
        <property type="nucleotide sequence ID" value="XM_027763779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2L2"/>
    <dbReference type="GeneID" id="38785584"/>
    <dbReference type="InParanoid" id="A0A401H2L2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="932" mass="103098" checksum="1EFC47B5F73FA8B5" modified="2019-05-08" version="1">MPARFVILTEHQPILSEKLRSYDMADAKGRKTLVQSLRQKLKTQFVDTSNYDDIIVETKIREWLNNHARHAQEKATKKRMHVSGKPNAFKVWDALERDKVTEAARALAADKGCNVSKVWRVARSAEWAKLSEEEQKVYEEKAESWRNGTLDDKTKMKLREQRMMQYLKKFAKTMWDTMGIRMAFMLAYPKEAGSLKVEMVEVNHAITNGTPFGAYPGWLRAYQPLAKVFSEWAKGEYGVTETTVTVKKTPADCMQAMDKIQLMANGFPLLPSVPEGMAEAPLKVMKVQVRDFMNHHYALAKGVRNCKSPWTKLNSIDDINEVIPAEMLPENFQWIDPSKMTSVPVRALLDHWRACQEEHGPEQTMRFTQYFDKDGEAAPAKYDPLPPLDGSAQALEEGSEHEVQEALTPKKAGKAKKKGKPVRKVTGKAASKATKGKAAPGGAKGKAAKTLIGVRQIYPAWLPKKIRPAMKIQGMANKVKGKAVATTNGRKANNGGAPQASGSGGAKTKAKRGLQDLPLGELHRFDTEETDEAWSELEPSTKELRLELQGRAPRLTGGSTVGSTVPHLVKRRDVFLATLSVEPRYQDMLKQVKIATVPQVYRFARYDPIPWSEWSYGQRYLPPSFHAVDNFDIVENWLGDKPWLTKYRFLHPQGFIEEGEPTNLPDYVVNSAISFDTVEQLLRCCEIITLDMVEGNVTHAMVKPVSKPAIRGAPQGGDGLGGQEEQEGDASARTHDGAATAAKVHKAHQPAPMADKPIIPSGGDEGPSQETSGGASNNGEEDDAHLSVPSSGAERPPPPPFIPKTRKAAATEDRPSGQAKALQGRSITDALQSNIPGRITRSQRQAMDESPAKNTRSQHPLGAVKDLKKLPDPKWERQPARPEPDGEDSSGEDNPPPRKRGRGTRDELVVALPRKKNARAEDSDDGDKPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2U3</accession>
    <name>A0A401H2U3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1401270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619635.1">
        <property type="nucleotide sequence ID" value="XM_027763834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2U3"/>
    <dbReference type="FunCoup" id="A0A401H2U3">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2U3"/>
    <dbReference type="GeneID" id="38785639"/>
    <dbReference type="InParanoid" id="A0A401H2U3"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE88722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="147" mass="15501" checksum="C5F28F6D232DA713" modified="2019-05-08" version="1">MAPKPASTAGKAPASTASKAPAKPTEGAKSAKKTSKAATGAEGEGKKKRRKARKETYSSYIYKVLKQVHPDTGISNKAMAILNSFVNDIFERIATEASKLASYSKKSTISSREIQTSVRLILPGELAKHAISEGTKSVTKFSSAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3B7</accession>
    <name>A0A401H3B7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619848.1">
        <property type="nucleotide sequence ID" value="XM_027764047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3B7"/>
    <dbReference type="GeneID" id="38785852"/>
    <dbReference type="InParanoid" id="A0A401H3B7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="226" mass="25189" checksum="4359118752D9C54E" modified="2019-05-08" version="1">MRRLSQVKGTADQAKPEYWPSIAYPYESDGINRLLCLIHGKGHPPTRIAIVLRLKHVPAPRHDSQATSHAAQERHAADKNVRRVLVPWVRPPRGRGTAPLDGERDGKRPPRVAARRARRASSASTSAWKYAGSNTGTWMSMRSRWVCASPRRNSATGMASDTPPIWSSVYTRKRTEAELQCEVFEGVGGCVYQALLEIERGGETPWHLERACAQHYRGLHGPCHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3C8</accession>
    <name>A0A401H3C8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619826.1">
        <property type="nucleotide sequence ID" value="XM_027764025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3C8"/>
    <dbReference type="STRING" id="139825.A0A401H3C8"/>
    <dbReference type="GeneID" id="38785830"/>
    <dbReference type="InParanoid" id="A0A401H3C8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052258">
        <property type="entry name" value="Diverse_Func_Domain-Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612">
        <property type="entry name" value="FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612:SF20">
        <property type="entry name" value="PER-HEXAMER REPEAT PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="324" mass="34835" checksum="44FEC9729CF27A85" modified="2019-05-08" version="1">MTLDIDPNYVLQAARLTAIVAAAPRQDDPRYSDWEARIYLEVSRLEKSFPQPLKSLRMPGIIISALLEFTRAYQQKALARLDHISNDDERIYKRYPLAVREYGECKDLGRQWWTEDPYCKLPPVKSTPAEGWGNVPADDDTQRCGEEDLAIGDLVTKGKGKERADNDVGTGMVGERIVHVEAGEDKGKGKSKEKVQGKAAHAMSEEEDGGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEEQEGEDDDDADSDEDNDADKDDNDEMAEDVPGAGQPEFIKVDAVSPPPPTARPISISPAAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3H9</accession>
    <name>A0A401H3H9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1404040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619909.1">
        <property type="nucleotide sequence ID" value="XM_027764108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3H9"/>
    <dbReference type="STRING" id="139825.A0A401H3H9"/>
    <dbReference type="GeneID" id="38785913"/>
    <dbReference type="InParanoid" id="A0A401H3H9"/>
    <dbReference type="OrthoDB" id="2803695at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="394"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="823"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="981"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1011"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1197"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1268"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1277" mass="142670" checksum="78FEA73969A10D5B" modified="2019-05-08" version="1">MPTVTLPGALLDLHAAEKDLWSWPTWATLVRTDHPPWSPEAEENPPEGWDANMVLAVRAFVEKYFNTKAKNKFDFMKRQTDEYSKGRNAWIQWVADTYRTCKVNARVDEILIEANRDPLTVMRAMKTSTLPSATDAVLWAFYEVTIYRVLGPEGLYENRMPKKGPNEFISVLLIHCWERWRKVVKRDQTAMKKKRAEVDRLWKEMSEKTPTKKDLRLFLGHIKTLMAKLERYGGDEALVAELAARKATLQAMQEALKKERGDKTRARTLPRAMLKALDSLSTAAEILVMQNELKEVLAACGPNDDEEGVAPEVPDGPDVEVEWEDGVEEFKTMTREELLEALGIPKEGIPGFSKKQSKEGLVDPWSEEFDKLAPEDLEDLEPRWHQLVGMLKMMLKMINGEPVLLMDSVGVGKTMQAVGVIALRQWYREYYTQHGRFPGLAGKRQMRSNEQLDGNFDARPSLIAVPANLIPQWEAEIKRYLLKRDFDVVLYLNKLKSRENWWQEVYAKSLHDPSHRIVLASVTALQDDARATLTINTPRWDVPVQHFRFATHGALTLFATKWGVFILDEGHEIRTLNWTYIAARFLMEISAMGIVLTATPVMTRPTDLWNMGRLLKLLAFAIENDDNALLMEREIRAAARRDRKVLKASGEDTHILNIVHGKGKAAATINESEEREKIVQWIEVIRHGFQGAVIRRTQASVDNEGQPISGLPPYIHLPLVVDLHQYELDNLDDIAKQMIEDGVVAKQAKYTSGKSFYLNIRRALTHPGCNHEFEYELPNTLEDWRNKPSKKLETLVEVLQHHLETDGAAPLAVTGPGLGNHPDHVEFHPVAGSPDKIVVYINFPSHLPLIGAVLDLYGIKYVTYDGDTTLAQRQVSLKEFKAADRDGPRVMIMSGVGLAGMNIACANHLIVVDTLWSAQEDEQLIGRVHRPPQAKPVLVYRIIAAKTPDVFLNNIAFNKAVMHQGFTGASTAIKKVFAVGSDDDAGSGDDDSDEDTEDPSEPDEDGSSKAPKPKPKAPKPKPKAQPKPRAPPKTKVPKPKPSQKQADVSDADVEVLEGPPQGKRKPRKKAQAAKSSAVVPSSSEEEDDEPTPGASGAAPVPSKTPKVTYQNRRKAAQPTATEEVVHAGTKRKDRKSMEEEVPKPAAKRSAQPEEASTTEAPMNVDDTLIAPSPPPPTSPSLNSLELGHNVNLPETPDLSQRDSIQPPSELSSLADEDSIKEFDEPPAPAPEPPRRVTRGSTRRTAAEVVKQARKNEQPTTFDQLPKDKRGKPRKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H439</accession>
    <name>A0A401H439_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1501560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620062.1">
        <property type="nucleotide sequence ID" value="XM_027764261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H439"/>
    <dbReference type="FunCoup" id="A0A401H439">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H439"/>
    <dbReference type="GeneID" id="38786066"/>
    <dbReference type="InParanoid" id="A0A401H439"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="411" mass="44817" checksum="2E95B64C5C6F2B68" modified="2019-05-08" version="1">MFKFNFDVDDDLDTDAPVAEEPGSASLPEQSRGLEDVPEKRFAEHPLLDLLSVLPPVISYSPLAVPLSSHRQLALARRDLFDARFQLILLGDEDPAGYAGGASELEFLDAPSDLVPGVYEGGLKTWECSLDLVDCLDSMHGSDYANSLRGKRILELGCGTALPTLYLLHQLFSSQPTPERPETHVHLQDYNDLVLRLVTLPNVILAWYMSPASASYRSSALSSNSDPEADQDPHPPADPTQLGELPLTPALTGAFRASLQEHKISLRFFSGSWGTFDLQAAGGSYDIILTSETIYRTDSLPSLVDLMWRACGGAGPTVDKADVQHEESADARPLEDLVSAQLSISPSAQYHCLVAAKLVYFGVGGGVSEFVHAVEDAPLSTRRERGAVQTVWERKQGVSRRVMRVVWGTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H448</accession>
    <name>A0A401H448_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1502000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620105.1">
        <property type="nucleotide sequence ID" value="XM_027764304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H448"/>
    <dbReference type="STRING" id="139825.A0A401H448"/>
    <dbReference type="GeneID" id="38786109"/>
    <dbReference type="InParanoid" id="A0A401H448"/>
    <dbReference type="OrthoDB" id="3264491at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MaoC-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="2">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25710" checksum="1E82EC66D7C95B86" modified="2019-05-08" version="1">MTKAGAAVFNFSATNEPYSEASGNFNPIHVNSYFADLAGVSPTITHSMWSSSLPGATLRRSLCKVARSELSRKYDVAFVGMVIPGDELRMKTRHSDIQDGNTVVKVETFNDKGSQEQGMAMDFYKSAPAARSVWDAADIHLTAVYGFSIIEIVKDNLEEKTIHFGGIKGQAMQQRHMYMNYDNIDGDGSVKTLLLHIQSSIWTLVCHTVWPIAQVMTERAVFEDMRSKDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4I7</accession>
    <name>A0A401H4I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620260.1">
        <property type="nucleotide sequence ID" value="XM_027764459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4I7"/>
    <dbReference type="GeneID" id="38786264"/>
    <dbReference type="InParanoid" id="A0A401H4I7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="12048" checksum="55589AB6ED91CB12" modified="2019-05-08" version="1">MTLVQIKRRSTFDSYMLLHNLLLKPDQLALRKVVEQLRQGLPAEDLDRLVQRSPQPRLRISTVDNLLSADSLILVDNSSKPWMSTFVDTFCDRLPIVRSISVSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4X9</accession>
    <name>A0A401H4X9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620313.1">
        <property type="nucleotide sequence ID" value="XM_027764512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4X9"/>
    <dbReference type="GeneID" id="38786317"/>
    <dbReference type="InParanoid" id="A0A401H4X9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8080" checksum="D12C51D4FF7A84A6" modified="2019-05-08" version="1">MTSAPTSYAVSAAPDAPDVMPRILGVDAVFASESQNDSVPDADAPSGCNSDGSESDWEDDVNPVEVGDARDDDGGFDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H528</accession>
    <name>A0A401H528_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1601650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620416.1">
        <property type="nucleotide sequence ID" value="XM_027764615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H528"/>
    <dbReference type="FunCoup" id="A0A401H528">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H528"/>
    <dbReference type="GeneID" id="38786420"/>
    <dbReference type="InParanoid" id="A0A401H528"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019101987" description="Thioredoxin domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="215" mass="23799" checksum="DC6124383C0E6EAA" modified="2019-05-08" version="1">MRLPWVVLTLTLAPSVVSAALFPADAKVEMLDTKSFRKAMKQNVTSVVAFVAPWCGHCQRMAPEFSKAAVVLTPMVPLYAVDCDNEANKRLCAEQGVQGFPTVKLFSRGGQSRAITFDSNERTSKSFFYWASKNIPHAVKRLDAVPNIRGWVEDNIAKPRAILLNPGKEIPLMWKSLGNKYKHAVSFSIHRDKTGKSAMKLGAEDHASKASRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H560</accession>
    <name>A0A401H560_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1601520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620403.1">
        <property type="nucleotide sequence ID" value="XM_027764602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H560"/>
    <dbReference type="STRING" id="139825.A0A401H560"/>
    <dbReference type="GeneID" id="38786407"/>
    <dbReference type="InParanoid" id="A0A401H560"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE89490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22776" checksum="451B706ED46541F8" modified="2019-05-08" version="1">MGWKANVAFMRYGARWRKHRKLFQEYFGQSQSLTYRAHQTEEARMLLKDLLTSPAEFKACTQKHALLSIIGIAYGHQVKLDDDVYVKFAQGAIHGVEEATAGTTLLDLIPFRASVKYIPYWLPGCASFTAAVRRWGPATKGLCEYPLNDVRKKMEAGTAQNSFLASHLECLNTDGADEEDLEDIKGAAATILVGKSNSFHLSSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5E3</accession>
    <name>A0A401H5E3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1603190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620568.1">
        <property type="nucleotide sequence ID" value="XM_027764767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5E3"/>
    <dbReference type="STRING" id="139825.A0A401H5E3"/>
    <dbReference type="GeneID" id="38786572"/>
    <dbReference type="InParanoid" id="A0A401H5E3"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="137"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE89655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="454" mass="50729" checksum="48C344027DA56BE0" modified="2019-05-08" version="1">MEEVLKQYPKPVGLEKIQFDHVPIFSVVGLQLSMFQEPWSHGVPVVVTHIDSVFQGNWGPAYFIESYGSRPVVVQDCETETTRNTTVKDFFMNFGISDRRSSILKLKDWPPQKAFSTEFPELFKAFIDAVPCPDLARLDGVLNLAAHFPLNGLAPDLGPKMYNAFASPQDNEHHGSTKLHMDVTDAVNIMLWAASNHDGKAGSALWHIFPASSVAVLRNFLREHGFTALGDPIHSQSMYLTPGLLDLLATYGVRPYVIHQHPGQAVFIPAGCPHQVSNEVDAIKIACDFLSINNVRETQEVVSQLRYQRLQSGFGDDVLQFFTTLWYTWKSLSHMSELVAVPDIFIVGGDTHSEPPATSEDILAEEQENALSFDTLAITSPGTRQIHEICSPTASHLTQGRDTLSHLEEKKKRRKEKKHAKAHSQRPQKPGFDFTCPIPHCAGYYHRAGLLDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6C9</accession>
    <name>A0A401H6C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1703000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620887.1">
        <property type="nucleotide sequence ID" value="XM_027765086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6C9"/>
    <dbReference type="GeneID" id="38786891"/>
    <dbReference type="InParanoid" id="A0A401H6C9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="56" mass="5481" checksum="B2CFEFA7EE544A0B" modified="2019-05-08" version="1">MASEEDTASDEDSGDGESVIANKVKGKAVATTNGRKANNGGAPQASGSGGAKTKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6I1</accession>
    <name>A0A401H6I1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620937.1">
        <property type="nucleotide sequence ID" value="XM_027765136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6I1"/>
    <dbReference type="STRING" id="139825.A0A401H6I1"/>
    <dbReference type="GeneID" id="38786941"/>
    <dbReference type="InParanoid" id="A0A401H6I1"/>
    <dbReference type="OrthoDB" id="3270804at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="1">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="271" mass="27427" checksum="183424CCF4F0EF19" modified="2019-05-08" version="1">MFVPLQLLPVAQGFSAQTPGHDWASIRLALEYTLAWVTAVENEDFCQCNYPRPGDPEVLDDLGMCIGDMCLDEPVGDNGKFVGEMDFKQQDLSPGAGAALVDDPAAPAIAAAPVVVAAALVVIAAAPIIVAAAPAIIPAPVTAAASAALAIVGPVVTGPGPIAQASAGPAAGAPAIAAIAAVPPAGPGGFEIPPGFAAAPGIELPCPAQPNDHAPFYCMMHERVVGVFNDWSIVAAYIHGIPGAFCKKYPSYFSALSAFNVAHTQGTVQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6J4</accession>
    <name>A0A401H6J4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE89980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620893.1">
        <property type="nucleotide sequence ID" value="XM_027765092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6J4"/>
    <dbReference type="GeneID" id="38786897"/>
    <dbReference type="InParanoid" id="A0A401H6J4"/>
    <dbReference type="OrthoDB" id="3250036at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="200" mass="22339" checksum="2864CEE4FF049C0C" modified="2019-05-08" version="1">MPVNLGNIHLDRYRNWELDHHFQSVAPDVIFISDIGPPLPVFISASNSYHAFDRWHHLNDRDMSHDTNSSSGFYGSLEHSAQPARNEMDYWTKNYPPAGDTTSSGGYSSSHNAWSNAVQRGRPEKDEITLDDSSQFVDSSSNGGPIVTELQDAQQGTDRAARGAFSLGEAMDPYARSSVESREEAGEMLASRYADRRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6P1</accession>
    <name>A0A401H6P1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620943.1">
        <property type="nucleotide sequence ID" value="XM_027765142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6P1"/>
    <dbReference type="GeneID" id="38786947"/>
    <dbReference type="InParanoid" id="A0A401H6P1"/>
    <dbReference type="OrthoDB" id="2801804at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="586" mass="67372" checksum="7278FEC037488DBD" modified="2019-05-08" version="1">MHRKFVKMSVSDFMKNFLPGEPPDMPNFERAFSGMPSEGAIEAHFYEPFKDAVNDADMCPGYKVAITQYKPDLNGSSKQKPDAALYPVDEVPTDARPNWNTQRLHFEFKRLSEQHDPLNDKPKSELEPDSQERADVRGQCISYAEMLLVRQQRAFCFTVAILGREARIFRWDRSGAIATERFNYITEPYLCEFLWRFAHLSPEEQGDDPTAIEVEPNSEEARLMREMAKPVEERCGHARKYFAESLDPSWKWWKLLIDVKEDTPGADADHKVLGEYLVGKPRFSARGVAGRATRGYVALDCRTKMFVWLKDAWRVDHDGMEKEGDILHRLNELKIQNVPTLLQHGDVLQHGDILRQRTLSQDHWKAPASRATMQNPLKSHTHYRLVEKEVCRPLSDFDNSKQLVTLVFDCIQAHEQAMKRARLTHRDISGGNLLINEYESVGPRGTPCTVRDGILGDWELSKPIPLEGDTSDQGARQPDRTGTWQFMSVNALNDPRRTIVIQDELESFFHVLLYYGTRYLAHNFLDVTGFLYLFFDADFWDVANARFVCGHTKDRAMHTGQPAPSKFHNNYTSGLVQRALHHVSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H722</accession>
    <name>A0A401H722_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1900090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621073.1">
        <property type="nucleotide sequence ID" value="XM_027765272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H722"/>
    <dbReference type="GeneID" id="38787077"/>
    <dbReference type="InParanoid" id="A0A401H722"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="93" mass="10855" checksum="2646481ED07639C3" modified="2019-05-08" version="1">MVPREVRTAKSRHTRNVNRDAQTISTLQYMLQKSEGEVALMKDELARLKTRHEQYTERQAAAARFRKTVRRTLLGDETAMKEFDKFLETGEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5D8</accession>
    <name>A0A401G5D8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0102500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608290.1">
        <property type="nucleotide sequence ID" value="XM_027752489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5D8"/>
    <dbReference type="STRING" id="139825.A0A401G5D8"/>
    <dbReference type="GeneID" id="38774294"/>
    <dbReference type="InParanoid" id="A0A401G5D8"/>
    <dbReference type="OrthoDB" id="2756088at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="217" mass="23800" checksum="7C3B174F46ED80EE" modified="2019-05-08" version="1">MALWSDWGNNATTMLEDYYQLANSLALFGEKTWTGSGVRDTELTLEEFSNAYPILNVAAPGQNLNRAVKTEYGNTVYEYPGTYNTLITPVSSVGPPYTLTFSVMPDAADPDTGLLFSGKDSRLWVANLTFEATGQLYALGYMLPVGKYTNMSIHATREYTYAIIDGDDGNPYFWVTIMDIWEEYMAVGNMSFAAPAQYVGGQGFAGTIKNISLTLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5V8</accession>
    <name>A0A401G5V8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plant basic secretory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0104330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608468.1">
        <property type="nucleotide sequence ID" value="XM_027752667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5V8"/>
    <dbReference type="STRING" id="139825.A0A401G5V8"/>
    <dbReference type="GeneID" id="38774472"/>
    <dbReference type="InParanoid" id="A0A401G5V8"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="240" mass="26587" checksum="E4F58097F5E7D829" modified="2019-05-08" version="1">MPPYNYSPVYLSPPPAPPSSYGEPSSSWPIPTFELRVEDLAHPGARMFLESTQPADALKDAVVAVCSSLYTHESVPMNVRSVLLVLRSGMGVPAYTTGGPTHKEINVSLDHIRNCAVRAKDEILGVLTHEMTHCYQYNARGTCPGGFVEGIADWVRLRAGFVPPHWKAGRGDKWDAGYDSTAYFLEWIESRYGCGTVRELNATMKDKEYTPAIFEELTGHDVKGLWKLYGEYLATNPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5Z8</accession>
    <name>A0A401G5Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608509.1">
        <property type="nucleotide sequence ID" value="XM_027752708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5Z8"/>
    <dbReference type="STRING" id="139825.A0A401G5Z8"/>
    <dbReference type="GeneID" id="38774513"/>
    <dbReference type="InParanoid" id="A0A401G5Z8"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="80"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="486" mass="52166" checksum="7D244757032C98FD" modified="2019-05-08" version="1">MQIHAPTSSSTRSVATTAAVMKIYAGKLFDPYTRSLLKNRVISVSPDSGLITDVQAFSPADAARVDFSDAEVAVDLRAATVMPGFVDVHVHLFLHPYSEVNWEDQVTKESLAERTVRATIHAKRTLMAGYTAVRDLGTEGAGDADIALRKCVSGPDPLIPGPRYFTANRAIVTTGSYGPKSQIFLNKEGIDGVTGAEVVDGEVECVKAVRRQVGAGADLIKIYSDYRFRSRMNNAGKAVSNAAIATFNEKEVHALVSTAHALGVKVAAHAAHFHPNLVQDDLLQVSSIEHGYDLVLDGSSDITDETRARMEKLAALLTKSNTKWVPTLSAYHTMDGGAGETWKRASRAFKLALECGVTSIACGGDTGVFAHGDNALEMQLMVRLGADWRAVLSWGTLGGWELVRSMDWEGEKGRARLARVEELAEDARVVGDNEVPFGAVRKGFAADIVATTGNLESDFAGAVDKAAITFVMKGGRVYKRDGKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6X9</accession>
    <name>A0A401G6X9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0107900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608821.1">
        <property type="nucleotide sequence ID" value="XM_027753020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6X9"/>
    <dbReference type="FunCoup" id="A0A401G6X9">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6X9"/>
    <dbReference type="GeneID" id="38774825"/>
    <dbReference type="InParanoid" id="A0A401G6X9"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="201" mass="23940" checksum="9F3F9A6045934129" modified="2019-05-08" version="1">MGAYKYIGELYKKKQSDVLRFLLRVRCWEYRQLNVIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGNRKKHVPKGATYGKPVRQGVNHLKPQRGLRSVAEERVGRRCGNLRVLNSYWINQDGVYKYYEVILVDPNHKAIRRDPRINWITKPVHKRREARGLTSVGKQNRGLGKGHRYNHTPGWSTWKKHNTLSLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7D1</accession>
    <name>A0A401G7D1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0109580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608989.1">
        <property type="nucleotide sequence ID" value="XM_027753188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7D1"/>
    <dbReference type="STRING" id="139825.A0A401G7D1"/>
    <dbReference type="GeneID" id="38774993"/>
    <dbReference type="InParanoid" id="A0A401G7D1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="7519" checksum="5B00F97B7A3B7043" modified="2019-05-08" version="1">MAVGPSLRTLPMVVGRWLYNSPSGGGPITQKYTYGGGPIAQNTTYGGGPIAQNTTYGGGPIAQNTTYGGQPMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7S6</accession>
    <name>A0A401G7S6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0111040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609134.1">
        <property type="nucleotide sequence ID" value="XM_027753333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7S6"/>
    <dbReference type="FunCoup" id="A0A401G7S6">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7S6"/>
    <dbReference type="GeneID" id="38775138"/>
    <dbReference type="InParanoid" id="A0A401G7S6"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="200" mass="22870" checksum="D8E8C1F9F528395A" modified="2019-05-08" version="1">MATFSSTPIVIDGKGHLLGRLASIISKQILTGQKIVVVRCEEINISGSFFRNKLRYHNFLHKRHIVNPKKSGPFHHRAPSKILYRAIRGMVPHKSARGAAALERLKLFEGIPPPYDRKKRMVVPEALRVLRLKPGRKYCTVKRLSHEVGWGYKDVVDRLEEKRKIKAQAFHERKLAAVKLRQKVTADTASSFEKLTQLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G827</accession>
    <name>A0A401G827_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0112250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609253.1">
        <property type="nucleotide sequence ID" value="XM_027753452.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38775257"/>
    <dbReference type="InParanoid" id="A0A401G827"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="7">
        <location>
            <begin position="256"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="8">
        <location>
            <begin position="742"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1731" mass="194771" checksum="716DEF853F63623B" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQPPEPAIHLIKMSNLSPMPLTDQIAGVLELMFCRKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELERKWPPPFGESEICIDQPATLVDMHERILAWILPRVLIPDRQTKMLQATRALHPAIAASKPSSTTASWRHNPLYFLPPEECAQFPAGSLCLSPGWFQQPLQHMESGRLETSASLKLEGGRSWLRDIHDSSALLGAILAVVHPTLYAAGRQCLGLIQQDPELREMALNWSSPFNALQVIANRETPFHRDSKTRYTFYDLLATLGNYTCAWLKFPAMRVAIDYSPGTVIAFCGKAIRHGVTRADGERLVYAYFMREGVQNRLGIPVPHWMQASYYASHIGMCTRDIMPKTDGDENTMQGMETVDGSFIGGTKLAEVMAKSQGVVITDGSVWLADLKVGGDGGKMCSVEKLCNKSRLVVDLDDEVEFVTKVAKQTTRGVRYVDVPLPMPTGSNVPSPSKSPSKAPDSGSLFNLDDGDVLGNIGVPIQLDPAARKTKTQNDFMRDWIPHRDDYLHAIVEMEAPPEPRNCAECKVDEGRWRCLDCMGRPLTCTDCCRNGHQRAPFHRIEHWQGQYFEPASLYRVGVCIHLGHGGDPCPLGAFTAHNNPAPVVAPGSNFWNASNEDLNAHDGEVPFNFAPLAGTLDGEARQTDDAPDPTWEEDVPPVLFRPPRRDSYGNRIIVIVDISGIHHIGVDWCQCEMAVERDMQLLQMGLYPGTVKDPHIAFTFAVLDDFLLENKECKTAALNYYSKLKRVTSNAFPGTVPDRYCELMRVSRQWRQFKYCKWHGFSHDALHPVEKGGLAIFCPACSQPGLNLPFDWQADPVQWKFKRGFVMDGNFSAEHMKMKHPEEDVALSDGQAFMVGQEDYKAHLVVAMESHQRSTCHEHRAVNQANVDRANLDATGIGATACARHGFFVPHTVIDFQKGERQMNMDYSLSNALLTLTGITLILVMYDIMCQYGVHVRKRFRHSAYLRMPFELKVDQGIGLFHVHGHQDCCFQRFSPNFIVGAGMVDGEVIETLWAPTNEVSGSTRGMTRAHRQEVLDDHMNDSNWKKTTRMVPTLMTKWKRVLLGFPRSKESFEALSASTDEDVLEAWQKEYDDAMEARQNDPKIMDTFDVQLMKAPGKDLTQLRLAGEESAKGLEKGTAGWLSTGLKIQEAQLKLANDIRKAGQNPSVAEDLKTLERRQRLEVSILTFQCRSEKFMGRLEDVPAMEDRDDGALWDSLDENPFQIHPEDAEYGEDAIPPERASLNLPSQIGFVAAVANGLQTLAAQELELRKGLMNDILHELCMALGLKSYLYHKRVRPANSVGTMTRAQAEVYAADQTVLACARLYSANRRAIMCLGATDEDLALYRPLDKKDLHVKTAVIEASTSGLRNVNLAWFWTMDVAGDRGSSEWMDEFYRVNWLHARARYERWREERVLVHSEMAWTIATFKRNAERWAHWLEMTDPSWRGHVCYAARQSSTSDAHPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVRWEEGLRREMFTIRGICGDLALAGHADHIDHGGVIASVLTVCTFNREVLRPISIDVKAIPRPTALVPRPKNLLEDSPDYWWKWDRQVGPAGSPMEAWWYKLGDLWEKVYTVSESTLVQLEQLHIRVANLTSWLHERTDQNLDVVLEELQEATRQLRELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8H0</accession>
    <name>A0A401G8H0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein wos2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0113690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609393.1">
        <property type="nucleotide sequence ID" value="XM_027753592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8H0"/>
    <dbReference type="FunCoup" id="A0A401G8H0">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8H0"/>
    <dbReference type="GeneID" id="38775397"/>
    <dbReference type="InParanoid" id="A0A401G8H0"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000013">
        <property type="entry name" value="Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="224" mass="24042" checksum="CD3617A6E556C68F" modified="2019-05-08" version="1">MAFHPEILWAQRSSESDEKKNILYLTVNLPDIKPETVEYDLTSTTISFKAKAGDAEKGLEERDYAFNFNLFADIVPEESLKHLTSRSITLALRKKEKKAEYWPRLTKEKVKTPFIKTDFGKWVDEDEQDGEKVDLSDDLDMGGMGGMPGGMGGMPGGMGGMPGGMGGMPGGMGGMPGGMDFEEMMKSMGGAGAGGAGPSGADVEDEDDEDDDGPPPLEEADTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Q0</accession>
    <name>A0A401G9Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609794.1">
        <property type="nucleotide sequence ID" value="XM_027753993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Q0"/>
    <dbReference type="GeneID" id="38775798"/>
    <dbReference type="InParanoid" id="A0A401G9Q0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8600" checksum="57B0EF2395B98A6A" modified="2019-05-08" version="1">MVHRSSSRYLSRRENKKRLCASRDTAWNGEHQTQRKCPSKAPKFCMLLDEGCSAGQDVNVDTGPRSAVSFNNQISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA70</accession>
    <name>A0A401GA70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Intermediate cleaving peptidase 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0202710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609987.1">
        <property type="nucleotide sequence ID" value="XM_027754186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA70"/>
    <dbReference type="FunCoup" id="A0A401GA70">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA70"/>
    <dbReference type="GeneID" id="38775991"/>
    <dbReference type="InParanoid" id="A0A401GA70"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="68"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="516" mass="56112" checksum="9897A775D67B6B34" modified="2019-05-08" version="1">MSLRTVVHAARSLSTQPFKSRVRRWCARRYATTAPSSSIPALKPSVYGQPLYPSHPHLMKPGEITPGIPAEEYERRRRALMDSLPDQSLVVCVAGQVKYMSGKIFYKFRQASDFWYLTGFAEPASALVLEKAPSVPRRYRMTLFSAGTDPAAAQWDGARMSHADVVRHLGADDAQPVDALPAALRALAPRFDRVYLDLPPSASSRRGRPSSPKSLLKYLAPDALSRTDYDVLLDAFSSSKRKPLAPEVGRLRSIKSEAEQRVMRAAADISARAHAKTMRFAQPDMSEHVIAAHFEYLCAREGSLRPAYVPVVASGANALTIHYTANDQLVRDGELILMDAACEYNGYASDITRTFPASGTFTPPQAALYGAVLAAQKALVALCSAAAGHSLAQLHRASCDLLRAELARAGLPCPASGALAELYPHYVGHPVGIDLHESSHFERNEPIKAGMVITIEPGIYVPPSPAYPTHFHNIGIRIEDEVLVGEEHPIVLSVNAPKEIVDVEGACQGQLGLEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA83</accession>
    <name>A0A401GA83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol oxidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0202540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609970.1">
        <property type="nucleotide sequence ID" value="XM_027754169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA83"/>
    <dbReference type="STRING" id="139825.A0A401GA83"/>
    <dbReference type="GeneID" id="38775974"/>
    <dbReference type="InParanoid" id="A0A401GA83"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="560"/>
            <end position="561"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="651" mass="72246" checksum="53CCBEB9720BC0A5" modified="2019-05-08" version="1">MGHPEEVDVIVAGGGPAGCVVAGRLAYADPTLKVMLIEGGANNRDDPWVYRPGIYVRNMQRDGINDKATFYTDSLASPHMRGRHSIVPCANILGGGSSINFQMYTRASASDWDDFKTEGWTAKDLIPLMKRLENYQKPANNDTHGYDGPVAISNGGQITPVAQDFLRAAHAIGIPFSDDIQDLNTAHGAEIWAKYVNRHTGRRSDAATAYVHSVMDVQDNLYLRCNARVSRVLFDANNKAIGVAYVPSRNRTHGAQVQETIVKARKMVVLSSGTLGTPQILERSGVGNAELLRQLDIKVVSDLPGVGEEYQDHYTTLTLYRVSNETVTTDEFLRGVKEVQKELFAEWETSPEKARLSSNSIDAGFKIRPTEAELKEMGPEFNELWDRYFKNKPDKPVMFGSIVSGGYADHTLLPPGKYITMFQYLEYPASRGKIHVKSQNPYVEPFFDSGFMNNKADFAPIRWSYKKTRELARRMDAFRGELTSHHPHFHPASPAAAKDIDIRTAKEIYPDGLTVGIHMGTWHKPGETYDASKVHEDIVYTKEDDEAIDNWVADHVETTWHSMGTCAMKPREQGGVVDKRLSVYGTENLKCADLSICPDNLGTNTYSSALLVGEKAADLIVEELGLKLRTPHAPVPHAPIPTGKPSTQQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAT0</accession>
    <name>A0A401GAT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rdx family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610193.1">
        <property type="nucleotide sequence ID" value="XM_027754392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAT0"/>
    <dbReference type="GeneID" id="38776197"/>
    <dbReference type="InParanoid" id="A0A401GAT0"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16629" checksum="E2E00DD5B7FB530C" modified="2019-05-08" version="1">MADPGTCVECIPDIQHEGSSTLVQEYPVPAQPAHDLLDASTFVPPSSPPTSSITIEFCDRCRWLHRATWVSTELFLTFPAPILQSITILPLNSDATAGRFRVWLFLADCPPVLVWDRKIEGGFPELKVLKQRIRDRVQPGKSLGHSDHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBB8</accession>
    <name>A0A401GBB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0206680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610381.1">
        <property type="nucleotide sequence ID" value="XM_027754580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBB8"/>
    <dbReference type="FunCoup" id="A0A401GBB8">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBB8"/>
    <dbReference type="GeneID" id="38776385"/>
    <dbReference type="InParanoid" id="A0A401GBB8"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="552" mass="59806" checksum="F35D2CFC4B464396" modified="2019-05-08" version="1">MDPASRRAPSLASSLPSATLSSQQKSWLLSASLCHTLDRVNVLGDTTSGHTGCVNALSWANNGELLISGGDDTTVRLWRIDPSDSSREYPFVCNAVIHTGHRANIFNAQMLPNSSRIATVAGDGQVRISDAGSAVGQPSLGNETELTTRQANIRILRCHSGRVKRIVTEESPDLFLTVSEDGTVRQHDLRVSHGCQSGSCPTPLVRLDHELSTLALSPLTPYQFIVAGESPFGYLFDRRHAGRFLEEEWGMVPNSDNVTTCVRRFGRAAHGPAERRGHEHITGAKMASSNGHEVLLSYSGDAVYLYSTRDEPHSSSKSGHDSIVSPNTNANPAQNPSTIIGERHEAVLGPDTDVRMEEDIEQLLTEHGLIPDAPSSPLTGPGEDQEDGSDDEDDVAYPADEVFSNVPIILPRARFAGACNVETVKDVNFLGPRDDFVTSGSDDGNFFVWCKSTGKIHDILEGDGSVVNVVEGHPYLPLLAVSGIDTTVKLFAPAHGRSAFSRMEKHDDIVRRNTEASSRRLDLSSLFLQYAIARRVAEGNTGNENATQCTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBK6</accession>
    <name>A0A401GBK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dihydroorotase</fullName>
            <ecNumber evidence="3">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0207450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610458.1">
        <property type="nucleotide sequence ID" value="XM_027754657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBK6"/>
    <dbReference type="FunCoup" id="A0A401GBK6">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBK6"/>
    <dbReference type="GeneID" id="38776462"/>
    <dbReference type="InParanoid" id="A0A401GBK6"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01294">
        <property type="entry name" value="DHOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000071">
        <property type="entry name" value="Dihydroorotase, homodimeric type, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="74"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="348" mass="38354" checksum="C38BFE1841DECF49" modified="2019-05-08" version="1">MSTISLASPADFHVHLRQGDLSNLVTKHVRQGGFKLAYVMPNLKPPITTTDQALLYKAQLQSIDPAVEYLMTLYLSPELTPDEIRKAKRSGIVGVKSYPRGVTTNSEGGIESYEAYYPVFEAMEKEGMVLNLHGEVPSDALTDVCVLNAEPAFLPHLRKLHARFPRLRIVLEHATTRAAVECVKSLGHTVACTITAHHLAMTVDDWAGQSWNYCKPVAKYPDDRQALRDVIKEGHPRFFLGSDSAPHAPNTKSTASPLHPCAAGVYTSPILLPLVAHLLESFGALKRLEEFVSANGRAFYGVPVPDGDSQVMLQKVQGNVIEEKWVLGKQSVVPFWAGRPLDWKIVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCD7</accession>
    <name>A0A401GCD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0210490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610761.1">
        <property type="nucleotide sequence ID" value="XM_027754960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCD7"/>
    <dbReference type="GeneID" id="38776765"/>
    <dbReference type="InParanoid" id="A0A401GCD7"/>
    <dbReference type="OrthoDB" id="2587968at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="177" mass="20368" checksum="CCEB02C0D3315BE2" modified="2019-05-08" version="1">MAMRIVHIPANAFKSVITYCTPEARDLIYHTAVERFPTATSNTDPYNLEQRPPRSNEPTPANIGFGFTEPVSDHPFRSMRYLKKFVLESMAENREVHKVIIRRGSGGVDENGQKMDTVTGRHGLRLLIPTQNFPKKDVWAWRLLSEEERAMLEDTQAVENEPKVVLHPRHDDARARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCQ9</accession>
    <name>A0A401GCQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211710</name>
        <name evidence="3" type="ORF">SCP_0211840</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610882.1">
        <property type="nucleotide sequence ID" value="XM_027755081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCQ9"/>
    <dbReference type="STRING" id="139825.A0A401GCQ9"/>
    <dbReference type="GeneID" id="38776886"/>
    <dbReference type="InParanoid" id="A0A401GCQ9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="207" mass="23116" checksum="B18C17143611F82C" modified="2019-05-08" version="1">MEVQFQERMADLNTVKAEITAALQRINPPSAFQENARSIREEVKLAMEEFRRPVTIELQESMKLAVADLVAKRHCLPELKEKVNRLEQGANQTVSQADVNKLQGELADLRHSMELQAARSDSMEKELRSLAAEAIAQASKLEMELVLAKEDSMAVATSALDEAKKVAKEVVTAREETSLVAKSLDAFREKVDSAMVFTAFHPDRHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD78</accession>
    <name>A0A401GD78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0213130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
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        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
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    </dbReference>
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        <property type="entry name" value="SAM_MT_TRM10"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
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            <begin position="82"/>
            <end position="338"/>
        </location>
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            <begin position="1"/>
            <end position="88"/>
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            <begin position="341"/>
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            <begin position="1"/>
            <end position="17"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="40"/>
            <end position="70"/>
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        <location>
            <begin position="380"/>
            <end position="389"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00012797"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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        <source>
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        <source>
            <dbReference type="EMBL" id="GBE80110.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="398" mass="44893" checksum="16C8E2737FE95381" modified="2019-05-08" version="1">MDAAEEAIVDPPAEESPEIGSSSAQGLSKNAQKRLAKAARRTEQKKERRAAEKERKKEKKRVQAEKRVAGELDEEVDGRSRKKRRIDEQKGLRQPFGARVVVDLGFDDLMSEKEIISLTSQLAYTSSANRKAIRPFASLLFTSLNGRTFTRLENLTNAAYKRWVDTEWWTEGYEQLWEDQKAERADVEGVTEGGEKNGNGDGKVHDATGKIEGGHDLQEADAKFRHLELAQKPQTADRETVVYLTADSPEELTELNEGKTYIIGGICDHNRYKNLCQKKSVESGVRSARLPIGTYLSTLRTRKVLTVNQTIEILLKWIETRDWEKAFWDVIPKRKFQEKRSRNGAVITNEENESDADAEGAQNGDDGVERMVIDVRALEEAETESMDGGEEPKLPDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDG2</accession>
    <name>A0A401GDG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0214100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="20"/>
        </location>
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    <feature type="chain" id="PRO_5019525040" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="52"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="256"/>
            <end position="362"/>
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            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="140"/>
            <end position="175"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
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            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="GBE80200.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="362" mass="38719" checksum="D83D05B61D6D8858" modified="2019-05-08" version="1">MPAPAVYIIAALSAVVAVVAFKEFVYEPHVAPKIEAWAEAFLENRRRRRHRLTAAPVPQYTTQDGRDENRARRSGSDGERGEMPVELEQLVTQEVNEWRGSPNGSGLRHRRTAGMMDESNTFIPYSTLSPTHVLFDSSAPSSPVSPLERPSLPSSPRSIGEHSVSASPSTSVHSLSGRHQTPQVAFRVTSPRLPTPISNYSDPSSRALTPNITDIGSSVSSGSSKASTPGASDINIPASMYNTAMMDTSELGHGATVLANPTSRSHSPFSDVYSVETHSSGSTSPDVRSPNIGSDFDLPSDDDYDVLSPRSGMFSPGSAQEVLSPHFGMLDAGGGHEDVSDARSQQGSEASWASVGRRTPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDG6</accession>
    <name>A0A401GDG6_9APHY</name>
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        </submittedName>
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        <name evidence="1" type="ORF">SCP_0214390</name>
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    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="406" mass="45524" checksum="32308E53A9E9B50A" modified="2019-05-08" version="1">MHSVTHARSSRLPPEILEHIFLCNFSYEVPGADIHAHENPHSWRANVKSILPCCGVSRDWYCVASGLLYRQRIDIRSVKAMKLLLRTVKEFKTRRESCPIRHLSVCNYAILHSSTFRQELNELTTVLLAHCTELQCLECRFISLLQSPNTPSPFPIFSSLRELSIGDVHLGDIAPLLICAPALKRLDASMLGNPLFPSPSDALDALLSVPPPAFSLRDLRVANCRLSQAQARWLLANSRDIAQVDLLAGQYGMLAPLSCTIGRTVHSLYIRDFPQDSVGVAHDISRFTRLTALRLGHYDWSWSELLSAITAPLEWLELPYSKVALTYLTTALSDRTWLQSLGKVVIYHLGNTDRLHQVNSADVKANRKMLKEVCYIRGIECSWVEEKVSGRDVGVVCLSKCGIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDQ8</accession>
    <name>A0A401GDQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0214890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
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                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027755383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDQ8"/>
    <dbReference type="STRING" id="139825.A0A401GDQ8"/>
    <dbReference type="GeneID" id="38777188"/>
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    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="429" mass="47849" checksum="4AB9EA8E8BAD754C" modified="2019-05-08" version="1">MQNTFLILVMSRRLSTIHDLAALRLHPDCTRVVNETVPNLSLRQARYTAYDVRGNWFARDAGGRIGVRKTRTRGKGKGKAREGEEDEDGEVFDLTGVNGGEGDSLVDEGKTDEEDPRARKRRRFAEDLSFLDSPRSSSVAGSLPPSVPEVVLGESHDVAPTHAALSSFSFSTPSSDLLKCIHHFASTYYTAAGQLYDASREARREKRRRRLARAAAGNLADEHDHSDAEEDDEQENENSDSGNEDGDEEGSDTEQEPDDSAHMRWRTHKLLTARKDMYKIFDGSALMVLGMLFQEHIAALLRSTPPAGWEDSAPPRKSRKRKRTAEEEDAPAQNTLKSKGKDKTQGKGKPMRGRRSKDEESEAKSSDTDTNGQACGEEDDDRDKWSTEEEQSARPRRSNRTRSCSSAQTGKNSQVPFVDDNEDDEDYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE01</accession>
    <name>A0A401GE01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0301270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611325.1">
        <property type="nucleotide sequence ID" value="XM_027755524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE01"/>
    <dbReference type="STRING" id="139825.A0A401GE01"/>
    <dbReference type="GeneID" id="38777329"/>
    <dbReference type="InParanoid" id="A0A401GE01"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="906"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="974" mass="103987" checksum="3D47BAA315CEA34D" modified="2019-05-08" version="1">MGSYEGAFNSSVLELVAPQESVGFPSGYGEKEAAEWLARLHEEGSDRKVAFFDENLALILTIRFPHDSFEDASQANAAAKPDPPLQLLSFLAHLQVSYEASYISPTAPAALSATAPEIARPPVPPRTTSMGKNKPALLQAKQHPSIFPPNTPLPIPAAAKSDRKYVQAQGMLLASGVWGEDLLGNNPSANSQDAFALLWAPETQEWVAVYRLSVLVSFMATKIPDPLLCLTVSATLREKPLAMTPSRHALAALIDTVGGLPNVLGQVMSPSKANGPDTEGNTEDDGDDVHLYGLEEINLLENLNLDPTFASSNLSLPSTRLGPNTRVSAFSLPPKSLPPIVDTTSPSTPTASRPLTHATLRKSFRKTMATASGFRVRMRTVFVPYFLLPKTSKPPRDGGGVEDDVDSDPDALQARDQREAGNEEHTVVLSVEIENAYTDELRGSSASPPYNFAVEDVVVKIGGSGARTVLVPWGTEDPADIFPIHIAPSEQVNLLYAVSFLRGPEVDEFSLAGTSAKSDPVAAAMSEKELQRSVTINIHGRPFERVKGHPEEETESQEQEVLSYPTRVYPSRWNCVLDLASRPPPMPPGTETPHHSVLPTPASPFPSMPTPTPGQPGLSINRSNVLQVGSAGSSRSSTPAVAGNKRFASAFDTPQTALDARAQSYARMPRSPINYQGATAMLNPANQPQTSPQQQQTQGTPTLTNPFDRRTSYLPPSITFESTYARSPTTYNAPQSPPAPVPPSFSSLAAPPEDAEPRTPAYPAYPGSPPPPPPTPYWQAPLAQQTGAGAVGPSVEIRRERGGVPPTPGPRVGGFGMGAEGPGAGAGAGAAGEPIVVSVGLLPMPARGDAGGRGEPGGIYPLDQFTLDIFVFNQSSWTRRFEVSCPEERRRRRRRRGEGNVGPPGILPLESRVRVGPLLPSTCQSVRMDFLALAPGVHSVDTLTLTDVRTGFTMHLKSVMDVVVLEPPPEAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEB3</accession>
    <name>A0A401GEB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0302310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611429.1">
        <property type="nucleotide sequence ID" value="XM_027755628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEB3"/>
    <dbReference type="GeneID" id="38777433"/>
    <dbReference type="InParanoid" id="A0A401GEB3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8205" checksum="B3A24E469E186F3B" modified="2019-05-08" version="1">MDAEAAYQLRCDVVLMLSVTESLAAGSLDRTATVQTRGATGASRGKGWYGDRDSHIDGNSSMWVSDETLDHTLPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEF6</accession>
    <name>A0A401GEF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611418.1">
        <property type="nucleotide sequence ID" value="XM_027755617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEF6"/>
    <dbReference type="GeneID" id="38777422"/>
    <dbReference type="InParanoid" id="A0A401GEF6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="96" mass="10602" checksum="8C42AD1874C01188" modified="2019-05-08" version="1">MTEPQCYRGDHLVGERVQDYTSQKYSARNRNESLGSGVGSNKRFLKSSRSVTGTPPRLPRLVVPHAICDQALGKRNLRDANELLFFGKLLDAAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEF9</accession>
    <name>A0A401GEF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0302360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611434.1">
        <property type="nucleotide sequence ID" value="XM_027755633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEF9"/>
    <dbReference type="STRING" id="139825.A0A401GEF9"/>
    <dbReference type="GeneID" id="38777438"/>
    <dbReference type="InParanoid" id="A0A401GEF9"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="490" mass="53828" checksum="DD2A953F11811980" modified="2019-05-08" version="1">MSQHSLPLSATDVESDPEFLPTPVDVPYDDRTYPYQIAGHQFCHSSDQAASGGSPASCSPSHNVAHSDFYQEGSLPFFDQQACCGRVDPNGADSLKWTKHGYENFLPGHNGIWPHRQEYQEGSLSPQQLSPDEHYHELQPSYISASETPQGQQTVGGHSPATVSGSTRAFRDRVLNSNYSESSRTSFYPSTSAVSDSEIFPDSLSSPVETSTFFSVPVNAQLPGEAYTQYYPGSGLSHSSQHASSSACPDVRGDISSGYPNPNPQDRSHVPAFSQPELLMGHTQYDDNLDHSANKDSADRWAASEYDHHYPYPQSDANYLALASVQSQSQPISQPPQQRRHYAVALHNSPPCPYSYPRFTETEYPFTSHIHAPQPHPWPTLRPPAVGGNHSLAIHGSMHSGVSSAPTVTHSPPLVEDNPKRPLTLACLFCRKRKIACGSPPPGKKDRTCNQCARRNLKCVYPDVSRRGMRPKLLYDKDSIPVVPPLLPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEK2</accession>
    <name>A0A401GEK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0303270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611525.1">
        <property type="nucleotide sequence ID" value="XM_027755724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEK2"/>
    <dbReference type="STRING" id="139825.A0A401GEK2"/>
    <dbReference type="GeneID" id="38777529"/>
    <dbReference type="InParanoid" id="A0A401GEK2"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35607" checksum="F0D52C41C016E80C" modified="2019-05-08" version="1">MPRPPEYIRMLKIGFDALSSHGDEQEGDHSHMVRIICNPYVQVGGEHVAAPIGMHPSVIEVMPPSNYGLFLQEYRRTFSHPVFPCRTAPWYDDNRGLPHLKMSNPVEVDQRELVRIYPAVRLPIIFTAPVGHAKPSAISISCGGVACMEQHQPFVPFDDIIPLPPRYYPMKRVVQSGIDPDTEGWRLEGLVGLWLGMHGQQGTECLFVSWHTDEEELRAWKITGDINVPRGVCSWILRTHVGVTSRHPALLETWNRLNLSVARVYVGTGIISERGFAKPTSVDLIIGVTGADEIKIWWDQVNDIRTYIRYVGRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGC3</accession>
    <name>A0A401GGC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0308790</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612066.1">
        <property type="nucleotide sequence ID" value="XM_027756265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGC3"/>
    <dbReference type="STRING" id="139825.A0A401GGC3"/>
    <dbReference type="GeneID" id="38778070"/>
    <dbReference type="InParanoid" id="A0A401GGC3"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="14">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="243"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR633865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE81153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="525" mass="58018" checksum="0804E1A2300D3619" modified="2019-05-08" version="1">MTSLDTLIPVIYHEKQQPGSMLCAQHALNNLLQGNFFTAPDLSAIAESLDALEESYDADRGRASTNMDDTGFFSVQVLENALQVWGLTLIRWRSEAMRPYQQFPQTQMAFILNHEQHWLTLRRFGHVSPAPLHADSGGGHWFNLNSFLEAPQWISNTYLGMVLQQSEAEGYSVFAVIQTDPEGPLALPRTEADELAASIPESSAPSSGNRISTSRTPPSSVALHGFEDEDMELQAALQASLTGSPHDFLHPPSSAPSSSSAYREANRGVPPAAQYPYYNHGEPPELEPVDDEDDEEGDAAPMDPVAASMARNRAIMERMRREQEAALREGYEQEAARVEWAAAHRPPQAVQEHDDYEEMLRRAIEESEAEARVRDRPATQHTDEGEAADADENEDEDMDDEDYAPPVVPPRIPHPSSSYGARVYDDEDAELQAALKASLESVPEDFRFPSPRPPIRPLPPSSGASSLSTPREQQTPHGTATPQRPEEDTEDAETQSEAESSSAAEPEEQLSVEEIRKRRLAKFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGC6</accession>
    <name>A0A401GGC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0309630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612149.1">
        <property type="nucleotide sequence ID" value="XM_027756348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGC6"/>
    <dbReference type="GeneID" id="38778153"/>
    <dbReference type="InParanoid" id="A0A401GGC6"/>
    <dbReference type="OrthoDB" id="3269456at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="341" mass="37950" checksum="FE745FDA273D48F7" modified="2019-05-08" version="1">MAKVFQDARCVKLFDEWTTRTKAPNPEMGADGQGSQFLLETYDQFETVERQFDVQVGSGGYLYLVWRSSREEVTLRVSGFVSQMSLLPPFRRSFRLPRGNPNLALQTVVVAGEGPAFRRAITARSNILRFMEMHAHRGTTSVIDDVWLGAMPCFIAETRVLTPMVEAPLFDSADLNMVIDPYGALAELVAGGRLSWTSDNVVSCMELKGEYDDRWSTPVQSSLDMVRAGELVELSVNFRLREHMSPNGANVGRKFLTRLDTVMIVSRLGMKLIADCESEHLSMMRIAAAADNTGGGKAPKKRRFSYLQSVPSVLTSTEQHLNSLTVLDKTDDVDQVMKPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGZ1</accession>
    <name>A0A401GGZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromatin structure-remodeling complex subunit sfh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0311240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612308.1">
        <property type="nucleotide sequence ID" value="XM_027756507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGZ1"/>
    <dbReference type="FunCoup" id="A0A401GGZ1">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGZ1"/>
    <dbReference type="GeneID" id="38778312"/>
    <dbReference type="InParanoid" id="A0A401GGZ1"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="529" mass="57805" checksum="D899756E7E7D1F1B" modified="2019-05-08" version="1">MAEAQVWRAPNQLLNVPNRASQSSVPPQAAHPAYFNNIRQWSNSVTPPPTNGRINPSRKSNRPHRGSTLASTPQTQASTSTYQPAPPAPTFNPPPLEIFPSSSQSTIATTPQALHSTYASRLRTGATLLVQPTLASSSATAVATRSSRRGGVVNYADPGSGDEFPDAGAIDSDDSDFVASGGTRSAVRAARLSSKAPAGASVFHAGSVTPAAPAPPQPPQRAELDQSYLGMVPPSRYITAKPVYPTRHDYFPPEAMEAQAKRSTALVPIRVEFETDTHRIRDCFVWNLHEDLIKPEAFARTFCVDLDLPPNPWADTVANQIRAQLEDHEGVAAMDLGADTEEEELAGGDEVGECRVILSIDVQIATYHLLDHIEWDLLSPLTPEAFAVQLGAELGLSGEAIPLIAHAVHEELVKHKRDAIEWGVMGGDNREVVEDLSGDKPRDKSGLSLLKDKTGLGLGWGRTPKDGRGPKALKSVWRDWAEAEEFKTRFEVLSAEEVERREIERERASRRLRRETSKFQSQIISKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH15</accession>
    <name>A0A401GH15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0312150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612399.1">
        <property type="nucleotide sequence ID" value="XM_027756598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH15"/>
    <dbReference type="GeneID" id="38778403"/>
    <dbReference type="InParanoid" id="A0A401GH15"/>
    <dbReference type="OrthoDB" id="2766966at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="53094" checksum="0A6D3662A11C259B" modified="2019-05-08" version="1">MTESDSVELYDDELDVLWDEHPDDSEGLSSSTVSTFPLEIWEYIMEYLWDDTPSLKACSRTCRAWLQRAQLYIFLTITISWHCCELWQTRLTESPHITRYVRNLILVQNPTGRWIGPCDPAVYMLGLGLLLSIWQRPNQVQCLFLSGWRSAHVSEELREQIPTLFSMVKLIHFQHCYFEPSDFFLIVGGCPQLSTIAIEGTAVYRNMPLSLDLTQMYPKTETALRILRLNHMCSTKFPPLSSQCLLKGPFDLRISWMKFCIISDLTETQAFLSTAGSALRHLIVSLTSFVVPPCTTLEQLNLLGNTRLSSLLVHLSTDLFFSGLPSFLSRVDDTHSIERIYIHLCVGYSSLTDILYWAPVDQQLSRIARLFKDQSPVVVTFYLDAGTIMEPKSQTVIQGMADLLQQRLQDLQTERCRLRIVRADIYHTSTVIKDTPFRRATAITLYDSEPDGVVIPDVSILEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHS4</accession>
    <name>A0A401GHS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0400420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612584.1">
        <property type="nucleotide sequence ID" value="XM_027756783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHS4"/>
    <dbReference type="GeneID" id="38778588"/>
    <dbReference type="InParanoid" id="A0A401GHS4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="87" mass="10215" checksum="F27649C88F587EC0" modified="2019-05-08" version="1">MNDKLAENMVFPDQQHITELWTHLAQAEDKLTWPRACMREAHNESGTELLQCKAPGRDVDNITVVEYDRVKEIDIQILQVRHRQENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHW5</accession>
    <name>A0A401GHW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0401590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612699.1">
        <property type="nucleotide sequence ID" value="XM_027756898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHW5"/>
    <dbReference type="STRING" id="139825.A0A401GHW5"/>
    <dbReference type="GeneID" id="38778703"/>
    <dbReference type="InParanoid" id="A0A401GHW5"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="326"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="691" mass="78876" checksum="D15AFABFB7F96A2B" modified="2019-05-08" version="1">MNIRFAEENDFIRWELPKLIKVMNADGTPNQMGTITHCTWKMMKIGGRKTLTRFLLTGIGKENILLGMPWLKRLNPMINWETGDFWFGKDAKWPPKPTVEDAPDEEVSIFKEDGLPELITTETSPTLFGHSESIREIMADNTEHGELPAVRNDTEPDDPPSESPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMIMNALFKDMIDEGWIVIYMDDILIFSNELEEHHVRTRRVLQRLEDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVCSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVKSDTSKFATGAVLCQADINGDLHPCAYISQTLNPAERNYEIYDCELLGIIRALAEWRHYLEGSPHPVEVRSDHKNLTYFCTAQKLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ29</accession>
    <name>A0A401GJ29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0405670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613100.1">
        <property type="nucleotide sequence ID" value="XM_027757299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ29"/>
    <dbReference type="FunCoup" id="A0A401GJ29">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ29"/>
    <dbReference type="GeneID" id="38779104"/>
    <dbReference type="InParanoid" id="A0A401GJ29"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="567" mass="61016" checksum="BCFCD493695A4FB2" modified="2019-05-08" version="1">MAQHQPFDGAQHALHLNLNLKEADAYDTEELGLAQDAQNIVPSICGMPLKYVSLVTLAVQNASLTLIMHYSRVSAAPSHTYSAGAAVLVTELLKGFISLAIAFSRIESCSSNVPGTSSWNPRVFLYRFRRLGKEVFRSDCWKLSVPAILYVIQNNLQFVAVSNLEAATFQVSYQMKILTTAAFSVLLLRKKLNPTKWLALFFLAIGVGIVQIQSGTSSSSVVAAHDMNQFKGFMAVVAACFTSGLAGVYFEMVLKNSQADLWVRNVQLSLFSLLPALLPIVFSQTASATPGSGVFSMRLFENFGVWAWATVLVQVLGGLLTALVIKYADNILKGFATSLSIVISFLASVALFNFQMTITFILGSTVVLVATWMYNQPENVTDCSPFKECKAWWWKAMPSFRASSAVELSGGALSRRASMSSLSSLTSYSSGTMSFPGSPVERDEPILSQEKKRPEHAGRVQPLRAIRVAASQLAQFVAPHPNAIPALSSSTSLVFTAQENVGAAYVYPTSGHTFVQHAQGSLSTSASYPTSLSRPSSALSTYPTSRPASAMGGSVSSSTLVESAQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJL7</accession>
    <name>A0A401GJL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0407340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613263.1">
        <property type="nucleotide sequence ID" value="XM_027757462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJL7"/>
    <dbReference type="STRING" id="139825.A0A401GJL7"/>
    <dbReference type="GeneID" id="38779267"/>
    <dbReference type="InParanoid" id="A0A401GJL7"/>
    <dbReference type="OrthoDB" id="3263880at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="745" mass="82093" checksum="794DFDC43B93E055" modified="2019-05-08" version="1">MPGQPKSSRQQYSACGACRMRRVRCDLKDLPISASGQHPPCSNCSERGLKCVDEFAEVKAVKLLRRGRRLQQVEAVYGQNASEDSSLHSVSAPQSVIPGLKDEFFSSPFFHRLHIQRPIIEPMEFCPRFFEFSKGNKDALQVPGQLIALLLVIWAASFGVNEYGVEEVCDGPVNLRRRRDIVNEMLLEVLYLVDIHGILRKPTWDGVRALLLILPLTQEVQSPVERMAMHEATISQVYTLCSLASVSSVSSGQGDYVDALVRARVFWYTYVLDGVTSALRGGRILLTDDDLSSFEATLPPLGDNSGTSACYAFSYRYATIPIRIASACRQLHSALTGPKARQRNNVDEDKLQSVWQTLDQCWKDFDGLRQFGTAGFVQSEDVERFIDGWQVFIFECHNVIREALKQRLTRPAPDLSLIPEAHRAMRAREYEVLGRVHDKASHRCQIIVRDVVSILRRNIGQQLFKYDAALIRDGCFFAGFLLAGESGNGEDIETCLHALNEMHWAFSKSEEREQTVRMVWEARLSQSRPSTRGFGYSPTNDAMRPSTSEAPYSRRPTLRPLSVPPLSLNSFPGSLGSISAPSTACSTDGNWPSTISTTSSGTDPYRSYPSTANRSPPYVPAHNGLVLDTALPPKHDLIASPTYVLSSTGLSAGRTNETDSEQVFFFTPYSYMGMGDTQGPHQSAILPAATSSHSPTFSSSQFFDAAGVVFPNGTIAHSGSGTGNMSTTSAGNSGSRHIGGGDFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK29</accession>
    <name>A0A401GK29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Exocyst complex component Sec10-like alpha-helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0409110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613440.1">
        <property type="nucleotide sequence ID" value="XM_027757639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK29"/>
    <dbReference type="STRING" id="139825.A0A401GK29"/>
    <dbReference type="GeneID" id="38779444"/>
    <dbReference type="InParanoid" id="A0A401GK29"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="2">
        <location>
            <begin position="6"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="552" mass="61416" checksum="C1EDCEA3F613D848" modified="2019-05-08" version="1">MAEDVVYHMFEANMDEYLDEEIELVKQCFEMTCRQWDEQLSKQAPVTATTPDHARFLGSHNPAQVKRTVLASFTDVLLRPVTIVPRTVGKAVGAAFTSGSSAAVQGIAMLNPQRWGTGVGVGGLGQGGPGAFGRLGSWGVNERNGYATDFARTGDGTLFDVADEEEEVPNEKVEKKDKDSERTTRSSISSSTTVDIPSTAPTSAPSTRAGTPSTSNSAAAFDQLDLLLSLDIALELIHANRESLKRAETFSGYPGQFGHRVRDTIEELFVLLLQALGERHIRPGFDRATEQMKTYQPTTDTRNVAPLLQFFELVHIGDTMQSMVQVYFDKELSPHIDRTDFLNPVVREKKRFEDVLDDCVAAGLNAGTDALMNQVEYIILTLTKPREYYPAEDAPLELGPTRGCTEAIQCLQTHCQLLKGSTNKEVLEVFYQEIGIRLIAILQKHIKRQIISLNGGFQVISDLNAYYTFVSSLKVPSMVAEFSYLKMLGHVYVVDDAKDLAQIVRDVTRYGGAYKPEDVYEFIQRRADWKKIEKTVDKAMYNLSFKEDCVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKA4</accession>
    <name>A0A401GKA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0409630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613492.1">
        <property type="nucleotide sequence ID" value="XM_027757691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKA4"/>
    <dbReference type="FunCoup" id="A0A401GKA4">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKA4"/>
    <dbReference type="GeneID" id="38779496"/>
    <dbReference type="InParanoid" id="A0A401GKA4"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="100"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="421"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="578"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE82579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="627" mass="69779" checksum="C72CBC4AD5435B23" modified="2019-05-08" version="1">MLLDHYATLSPDTRKCLVQNLVMLRNKGVITSIALLRTLFPLLPRTTSSSLRALIRRTILSDVRTANLRTKNHKLNRAVQAMLFGMVERGMDAEVVGDRVAKVQSASLHFFLGGEEEQEDSDEDDDNEPDVKALQHRREINKKTRSGDKKIQKTMKSVKSKQKRKAESSTTNFPAIQLLNDPQTFGEKLYDSLNRHDKRFSLDHKILVMQLLSRIMGAHKLCILGFYTYLMKYLTYHQLRIPAILVALAQSVHDFTPPDALMPVVQKLAQEFVHPGVGSEVIAAGLNAIREVCRRQPWSMEEGLLSDLVEYRKSKDKAVTAAARGLLQLFREVNPGLLKRRQRGKEASMGMSSGAQPLPFGHTAVAAADIEGLVLLEEHLEKLRQENGKDDYQEVDDEAGWDGWDVESDSSSEASDDSGGWIDVESEGEEDLDISDSEDEADKLAKIKGRDDGHEPAQQMTFEEDAGTRISSLATTKILTPADFVLLNDLRIQSASQAVERGGGSSAKRKLATLESNKKGLAKSGNAEDTFISENDILGPRKKAKADYAERIASIEKGREGREKFGSLKGKKKKGAPSSSTNREKARNKPLMMVIASGAVRSKKKASLREKQQKLRAHIERAKKAYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKG1</accession>
    <name>A0A401GKG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0410480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613576.1">
        <property type="nucleotide sequence ID" value="XM_027757775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKG1"/>
    <dbReference type="STRING" id="139825.A0A401GKG1"/>
    <dbReference type="GeneID" id="38779580"/>
    <dbReference type="InParanoid" id="A0A401GKG1"/>
    <dbReference type="OrthoDB" id="2521594at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17640" checksum="B4DB51AB9948FF1C" modified="2019-05-08" version="1">MSKALYKNLDFKVELVNRLQHLHSFCGLEHGDVCGGNVLVKDDSPVFIDFEHARPHECKRTMAIEVGKPWPQALDFGCFELHDAGKYFGVWGPAIVEFLDDCISVYQITSPKRLVELTLHNDYIDPEDALEQAQEFVQYLVNRGTLPESVLMNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKL4</accession>
    <name>A0A401GKL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sterol regulatory element-binding protein cleavage-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0410770</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SCAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613605.1">
        <property type="nucleotide sequence ID" value="XM_027757804.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKL4"/>
    <dbReference type="GeneID" id="38779609"/>
    <dbReference type="InParanoid" id="A0A401GKL4"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032936">
        <property type="term" value="C:SREBP-SCAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045540">
        <property type="term" value="P:regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030225">
        <property type="entry name" value="SCAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46378:SF1">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN CLEAVAGE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="508"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="296"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1016"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1022"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE82692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1287" mass="139875" checksum="306F04CB1C0849B9" modified="2019-05-08" version="1">MEMSARIPSAILRRARAFGTSFFHRFGIHCATHQIRLILVSAVVITALLFPAIAIYTSPETHFFDGFTLRVLDSFLTPDDMSTYFAQHDLRHLWEGHANLRVREDSVARARCGMDGILRAERLLVSGVSQEDGLSALNHDTLLAALELERRISATLTTRHVRCLAEPDGGCFHLSPLAYWNHNEETLLADRDVLDTLNLLHNVSVSGIPIGPELVLTGRALHDSSPMNIDAAMFLALTYFFPDKDCVGNAGHYQWLHVLEEVAGHSGDLVVQAQTPRLVALEYNKESSTRSRLSVLSVFCLTAYFLFFVYCAITMRRMDTVHSRTGLAATGIVEILVSTLTSISVCALVGFRATMVPWELLPLIVIFIGVENMFHIVDAVLKTSVTLPVKERVAQGLSKAGTSNTLKSVSYNAVLGVIAFFSTGAIRQFCAFSIVVLVAHWFLVHTFFVTVLSIDIQRLELDELIRQGTPLMPANVPQQNSSKRPRSPWGKAVAFVQSTLRGRPAKNLSLLLLLAITATLYYATYPSTARDREDVRNSLHHSALAKLRKANLNANADAADRISPAFHIWQILNPADDPRVHIRIESPTILVLAPDNDAQADEATLALDYEKQYRARGTRLSRLWKPVMWLLKCMVFPISTTVLLLYALLLYLLKDAELLEAQRNRPEPDMSPPASDEVPSLEGACAFTTLPRAFPTDVDLVAASTDGGVVAAVGLQNELVVWFVESGTRVTVDVTGLLLGGTSTPSAAMALTAVAVDEAGSVCAVGTGSGVVGMWAVGKDQVRPLPNLTLINNSSSVSALCFGYVPDLVAATASKELAASLYATYENGTVTRWDLESPVGPHYIKPSLPASVVKSLLLPVHADERLLVGFALDDGTLELCDVGGSDRLLSRVCCLAAGNPTDLVMRAHVCALKLDGQRRLVVGAATRAGIVSLWDGGTGECVAILDEPYGDIGNLRITPVRARTCAVCGEFPVEGFLTTFSVGNVVLFFRGYVTLPTRHCSCPRNQPQQTLGTSIIGHRSRSGSAVSIVSSTGTTTPTRSRSRVSSLSTAPAPDISMFRVSAHGVHSRRVSEKDPRRNFDTFFVHADCDDCDVHPVGPQDVTPLSSFLASTAPPTIWQNLSISHVADATYERGCWGALDDKIVGVRRRPRPPFKSNGEAHVLGKTMSSRGLPTSALERWELWTFNPAESLLQASTLTVLNRDPPDDPPSPRRYEAALGLDGTHGRVTVPLPKRRKVDAVIPRLHFTRVSPLVSRTSVCLAGFGNTVGVFKFASGSANGHRHSAAKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKN8</accession>
    <name>A0A401GKN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0411110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613639.1">
        <property type="nucleotide sequence ID" value="XM_027757838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKN8"/>
    <dbReference type="STRING" id="139825.A0A401GKN8"/>
    <dbReference type="GeneID" id="38779643"/>
    <dbReference type="InParanoid" id="A0A401GKN8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="203" mass="22818" checksum="CB882DA162B17605" modified="2019-05-08" version="1">MEVQFQERMADLNTVKAEITAALQRINPPSTFQENARSIREEVKLAMEEFRRPVTIELQESVKLAVADLVAKQHCLPELKEKVNRLEQGMNQTVSQVDVDKLQGELADLRHSMELQAARSDSMEKELRSSAAEVITQASKLEMELVLAKEDSMAVVMSALDEVKKVAMAREETSLVAKSLDAFREKVDSAMVFTAFRPDSHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKV8</accession>
    <name>A0A401GKV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0411930</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613720.1">
        <property type="nucleotide sequence ID" value="XM_027757919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKV8"/>
    <dbReference type="FunCoup" id="A0A401GKV8">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKV8"/>
    <dbReference type="GeneID" id="38779724"/>
    <dbReference type="InParanoid" id="A0A401GKV8"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="225"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="324"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE82807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="482" mass="53120" checksum="EFB540EE0F1B404E" modified="2019-05-08" version="1">MTTPQKLRIAFIHPDLGIGGAERLVVDAALGLQKLGHSVDIYTSHHDPTHCFDETRDGTLRVHNVVPPFPRSYKGKFHILFSHARQLHLTAHLLRPSAPAFDVYFVDQLSTCVPLLRAFAGTRIVFYCHFPDKLLADGEYVEGKVQRKGGGALKRIYRLPMDLLEELTTRQADIILANSNFTSRVFKAHFRSIQTTPKVVYPGINLSAYEATSVDSQDPDMVAVASERPTLLSLNRFEKKKNAALAIDAFAILRKKLSENSTPTFENTRLVIAGGYDPRVEDNMMTLVGLIDHAKANSLTYNIITPSDSRITVPPFNCTPLGPDVLFLLNFTTSQRSALLSAPSTLVLLYTPTNEHFGIGPVEGMVCGLPILACNTGGPTESVVDQPPEERTGWLRPPVPETWAEALVEIVGMKRAEREALSTRATRRAREHFGMEAMAKGIEGTLQEAVAMGPVSSSFPHLALLAVLLVFVAYVLRTLDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL24</accession>
    <name>A0A401GL24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0412470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613773.1">
        <property type="nucleotide sequence ID" value="XM_027757972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL24"/>
    <dbReference type="STRING" id="139825.A0A401GL24"/>
    <dbReference type="GeneID" id="38779777"/>
    <dbReference type="InParanoid" id="A0A401GL24"/>
    <dbReference type="OrthoDB" id="2752460at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="232" mass="24692" checksum="F1CE54B8B5B3F0FE" modified="2019-05-08" version="1">MASITAPHSIHGAFGGLSFTPSYAVPAPSVSSPRAAAFAQIPNISLPSGRGTAGHGRARGLSILASRTASAPTEVSTPVARRAPPPPPSRIPYIPPQAEDPFADGPTILPDTDVEMQEVESYGPIIISLPPPPRPHPRSLPASPDFAPSQPAAPVRFESQPLPERQRGRLVASVLLNRGCGYGRPMMRRHFGGAREYVKSGLSRVLVPVEDDAQDDLFRRSPPLQIPLRAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLA2</accession>
    <name>A0A401GLA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0413350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613861.1">
        <property type="nucleotide sequence ID" value="XM_027758060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLA2"/>
    <dbReference type="GeneID" id="38779865"/>
    <dbReference type="InParanoid" id="A0A401GLA2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="185" mass="21279" checksum="FBB6C8EE90FB6AB5" modified="2019-05-08" version="1">MPAKARRRKRRLVLVGARACNGSIGGAIEAIERERSCTSPSYQERVRAKRCGRLQKGVFVEVISGAEEPRYSEEQQNDDSRRRLRAPVHPPLRESAHVHLEWAFLEVPSGSRFIHQGVPWRSRLVPMREDETRGCQRRYWNSPESCISAHPRRPRRFVRNDIQLPYPSGNGGGDVLGLRRVMSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLB2</accession>
    <name>A0A401GLB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0500010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613871.1">
        <property type="nucleotide sequence ID" value="XM_027758070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLB2"/>
    <dbReference type="FunCoup" id="A0A401GLB2">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLB2"/>
    <dbReference type="GeneID" id="38779875"/>
    <dbReference type="InParanoid" id="A0A401GLB2"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019522836" description="agmatinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="399" mass="42722" checksum="2C436E3E080ADC34" modified="2019-05-08" version="1">MKPFAPFASLVSLAISVVAHEGHDHDTQMPLDYVKYPWQAVYPGDNEVTADSIFSGITTFAKLPWVQCLGKDRNVAFDVAFIGAPFDTGTSYRPGARFGPAGIRAGSRRLTLYGGYNVPLAVNPFRSGLKIVDCGDIPVTPYDNKYAIQQIEQGHKALLHRAPFSPLGNDSLTGAPLEPLAVDGKSHPRIITLGGDHTIVLPLLRSIYSAYGAISVIHFDSHLDTWKPSVFGGAPSDQAAINHGTYFYWASQEGLIKNGSSIHGAIRTTLSGPADYANDDASGFQRIEAREIDTIGTAGIIKKIRETVGDEPVYLSIDIDSIDPAFAPATGTPETGGWSTRELRTILRGLDGLHIVSADIVEVAPAYDTNAELTTMAAADVLYEVLSVMAKTPLGKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMJ4</accession>
    <name>A0A401GMJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614302.1">
        <property type="nucleotide sequence ID" value="XM_027758501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMJ4"/>
    <dbReference type="GeneID" id="38780306"/>
    <dbReference type="InParanoid" id="A0A401GMJ4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="225" mass="25413" checksum="429263591F8C7E34" modified="2019-05-08" version="1">MRPPRRPAVGTPIPRLADHKTRAPPAHAVSSPLWLRFRDRARLDHHADLPACQHQSRAELLAKHMHPLVPTPHLARPKCASPLRTQFGVRSRPLSTAPRPLTPSTTYTRHLNHHVDLRLEREYRAWPTAKHAPPPRAPPPRPSRPHFATAPRSTTARTSRSNAKAAPGLSQSAPAQHTQFPRHSRPRFGTAPRRQMPTGMPQQSHREQLPPRPISSHNHHHGLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMP0</accession>
    <name>A0A401GMP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0505620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614424.1">
        <property type="nucleotide sequence ID" value="XM_027758623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMP0"/>
    <dbReference type="STRING" id="139825.A0A401GMP0"/>
    <dbReference type="GeneID" id="38780428"/>
    <dbReference type="InParanoid" id="A0A401GMP0"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_1G14540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17831" checksum="1D55A945F0EF6D89" modified="2019-05-08" version="1">MEVVWRPQSPSIGGIGQVTTRTFARSGCSVAVHYQAASSHAKADTLISDLKAIASSDARFAIFQTDLSNYDEVRRLHAEVVQQIGHPDILFANHGIAGPKVGPLGNINDMPMKVFEEMWWTNTGMSYMLAQLCVPHMEAQKYEQFSHQGNSLHRALIRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMS8</accession>
    <name>A0A401GMS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0500990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613967.1">
        <property type="nucleotide sequence ID" value="XM_027758166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMS8"/>
    <dbReference type="GeneID" id="38779971"/>
    <dbReference type="InParanoid" id="A0A401GMS8"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="5">
        <location>
            <begin position="68"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="270" mass="29350" checksum="25A44500E63BFF2A" modified="2019-05-08" version="1">MGSIDDLPPFTHDARAKFTTPPVPGWTFGQKVDATLEGREWLAGEKAGFQVVDAATADPSRLYALMISGIIPRPIAFVSSISETGTENLAPFSWFNMVTFDPPVVSFAVLHLPGARGFKDTLRNVMSTKEFTVNIISHAFVAGANATAVDAPTEVSEWPLSGLTKEPSIKIKAARVKESAFSMECEDLQLFQSHEIVHPETGKATTTLVLGLVKYIHVRKDVLNERGLVDPVKLNAVGRLGDITYSRQSDPFRVPRGTWAVDGAAISELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN27</accession>
    <name>A0A401GN27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0506710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614529.1">
        <property type="nucleotide sequence ID" value="XM_027758728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN27"/>
    <dbReference type="FunCoup" id="A0A401GN27">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GN27"/>
    <dbReference type="GeneID" id="38780533"/>
    <dbReference type="InParanoid" id="A0A401GN27"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="14"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="494" mass="53215" checksum="CF6A132C4323C5E0" modified="2019-05-08" version="1">MSQSLNKITVERNQRALLALVSEPGNDICADCKAWHPRWASHNLGIFICMNCASVHRKMGTHISKVKSITLDSWTKEQVEFMKQHGNVRSNAHYNPDETRHPPPTNMIDSERDSDLEKYIRAKYEYKSFVSRSSQVAALLGPSRSTSSNLSSAPTRSQTVTFQKNQNISLGSPAPPAVPPKTPISSVVSASMIPSNTTEARSASQPVFTSMQQPSQPSVQPPTFTSGWTNPVNPQQTFTMPSFPSSFATSSTFPPTSASQPIPVSTPNTLLPPSTNLYGALSVNSGSPFQSLMNQQSTGMPSNGISRSMSLNMGLSTNVGLDLNPSLNGSGTPSFQSPHTGFGYGTPASVHSPNPFLHQPLPTGPSTGTFGMSGMTSGQQSQLQPSLTPFNPSPFQPSPSPSFPQSATPQLQPSPMFQPQPLGQAPPTSANPFLQSQRQVQMPMSAPSAFGMGLPSPFGQLQAQQQQQMYTRNPFNGWQEGQQGNYTGQQWNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN51</accession>
    <name>A0A401GN51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein OPI10 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0507120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614570.1">
        <property type="nucleotide sequence ID" value="XM_027758769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN51"/>
    <dbReference type="FunCoup" id="A0A401GN51">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GN51"/>
    <dbReference type="GeneID" id="38780574"/>
    <dbReference type="InParanoid" id="A0A401GN51"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="143"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="204" mass="21813" checksum="60D3507B4DA9346A" modified="2019-05-08" version="1">MFGCLVAGRLLQTNLQQVDDTHAIFELPAASTINHICVFLLGNVPFPEGYGATVHFHWPGRGFQLLGMLSNDKPSAIFRLRGTFSASSSLAHDAFTGRPLADNASADVTAILGIAIEPLSVIMQEVANLPSALARPAQSPDSTFLAERIVKHLFNYIASFVAGSGGSAALAPESMVPLAVIARWYESFVNKVRNTGIGFLERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNH2</accession>
    <name>A0A401GNH2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0508330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614690.1">
        <property type="nucleotide sequence ID" value="XM_027758889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNH2"/>
    <dbReference type="FunCoup" id="A0A401GNH2">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNH2"/>
    <dbReference type="GeneID" id="38780694"/>
    <dbReference type="InParanoid" id="A0A401GNH2"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="6">
        <location>
            <begin position="229"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="8">
        <location>
            <begin position="475"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="7">
        <location>
            <begin position="572"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="4">
        <location>
            <begin position="711"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="93823" checksum="D976EF421EC1DE16" modified="2019-05-08" version="1">MSTPRTPITPIPQPPHSAGLAFKGLRANIDFNSIPSPIDAFDNDREQWNDQPYMTLPGSHVPLSTTEYVAIDQGNSSPRYIRMSTWHVPSTSRLASECEIPLVAMIQPFADQDPREEPVPLIDTGDIGPARCAGCRGYINPWCKWLSGGAKWKCNLCGHETEVAPEYFCNLDANLLRLDHLQRPELNKGTVDFAVSEEYWAPHPPPRIEPLYQSVVSEPASGLRKPEIMNYVFAFDISLEAIRSGFTHAACATLLDLLYGREDGSVEPCIPLESQICIISYDETLHFYDLSPRLDGHAPMLVVPERDDVFVPLRAGLFADPRESNSVIVKLLSALPVREESPAPEAALGSALTASLAILAGRGGQVVVFTGVIPAVGIGALTPPTDDSSVFGTEKEKQLFLPRHNAWRDIAEQCAEEGIGVNVFLGMGRPIDVASVGVVSSITGGELYFHPRFDPSRDVVVLASQLRRLLTRTTGYNCVMRVRCSSGLRVSQYFGNLHEPELSVTDIQFGTLDADKAFSVLFEHGRALDDHELAFIQCAVLYTARSGERRVRTCNLALQVVSLAGNVFRYADMDTVVCHMVREGISRLPSQQISQIQEQLTERCCAILLGYRKYCAASAAHTQLVIPEAFRTLPVYTLAIMKSKPLKARNIAADVRSYEAHKIMAMGAGATMQHLYPRLLALHDLDNFVALPDPGTGKIDFPSLMRNSHLFMESHGIYLIDNEELVIFWIGVNASPQLLKDFLDVDDIMQIDPHMIELPRLSTRLSTQVRNILAHRQAQRGWIPKTLIARQNMDAAELEFSDMLIEDQNNAAMSYLDYLCLVHKQITTALTTGSSITSRNGFLSTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNM9</accession>
    <name>A0A401GNM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0508820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614738.1">
        <property type="nucleotide sequence ID" value="XM_027758937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNM9"/>
    <dbReference type="FunCoup" id="A0A401GNM9">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNM9"/>
    <dbReference type="GeneID" id="38780742"/>
    <dbReference type="InParanoid" id="A0A401GNM9"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36467" checksum="D41219EA164B8594" modified="2019-05-08" version="1">MIIPQIFRPTFSPVLRAGTSSVHQKAPATRFISVSCPRRSAEPPQSIGNAAEAKSTANVEGKGKERATEATGKNEGDEMAFSLPLLQRPLGVRGRPTSLVKTWAQTREELMDQEMRMQKRNHLVKEATKGYFADLNATRRHGGKTWIAPRVMIREDKALYFPDISGTTLDNNTQAHTTHLCTGKVSIIAMLSSKISEIQTANFIDAAHAQYSSHPAYQYIQINLQENLLKSLLVSLFTSGIRKNVPQERWGKYLVSSQNMEYIRDDLGMTNRHVGYVYLVDEKCRIRWAGCADPKPEESEALKVCTNVLLDRHSKQKEELLVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP32</accession>
    <name>A0A401GP32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0510440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614898.1">
        <property type="nucleotide sequence ID" value="XM_027759097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP32"/>
    <dbReference type="STRING" id="139825.A0A401GP32"/>
    <dbReference type="GeneID" id="38780902"/>
    <dbReference type="InParanoid" id="A0A401GP32"/>
    <dbReference type="OrthoDB" id="3065555at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="1">
        <location>
            <begin position="301"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="639" mass="71395" checksum="A960D41246E96A14" modified="2019-05-08" version="1">MDNFPLKAVPRPPSPLACKRARFSKLERTEPSVVRQVSAAPWTQVLVPHGLHLPTQTATDFATIPDLAPPADVRMTPDRHASTTPVSASLAIMPMDNFALAQASLQASLDELEAASHEVRMDVVKRSQSDRGTGASYERHVRNYFSWWATFQQQETAKAPGRVAVPAELITAVKAVMFIQYESTCPKRKRGGADAQDGTTIGKSGIAQAISALESYRKNCEHLYKDVPDARVSLRADQRIRTVEDAAKHNEPLRIERAQALKAAGTSLDTYNDVQLTNAATGFLDISSGVRRLTTHIRDRAMLLTSSSTAFRGDNLRSLLWSDLSVRQIPMYDIQLGHKVPALVFMANNGKTNQNGRTDEFGAFRHCLVELCSIGLIALQLYSHFHIQNNSVPNFGADIADRNFGEYGRRDWYQYHLFYASRPDAPMLYETHRSRVNALHLQHEISITKVTHAGRSFAAQNMHSHGVSASDTKALGGWSESGSFRSCYDRELPIDAFVGSAMFNARQPDPPLSLKTAIFPWLEEQEHTMRARAEAEALAKDIALVQFFRVLSWFHHVLLQDMAVLYSRNPNALVFQYPPFNTTIFCTFAAEADTHIRATEEQSRLAFQHLPERFVTSVKGVVTGLELAQQQDHELNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPH1</accession>
    <name>A0A401GPH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615029.1">
        <property type="nucleotide sequence ID" value="XM_027759228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPH1"/>
    <dbReference type="STRING" id="139825.A0A401GPH1"/>
    <dbReference type="GeneID" id="38781033"/>
    <dbReference type="InParanoid" id="A0A401GPH1"/>
    <dbReference type="OrthoDB" id="2803071at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44084" checksum="ADBF37D48D28F19E" modified="2019-05-08" version="1">MSTSTQSSPSSPAQDSTFSILHPDGPTPTLLDESFFEHDYPRDPDAFCSFAERLEHDAEASRPYLRAGSPYPIHVVARWRSLDFPWLSPGSGSPAHRGVPPEMCSGAFVKEDANITITLTRPLQTGFCKWAQVWCANLRWCAPHEDATSNSESDRGAHVVVKIFQESAFRPPEYFDEDGIESGYWRTGAKQARAEALAYVCMMSLQGREVPWSYGFFKVRLPHGELAYAHVMEFVDGKAGGLTRLRNCTSQDLWTVMDAMASCLYAVIKCGVVQKDVTCENIIIRPGAAQPVVFVDFAAMQSLRSPSVGPVRDPELIEWDISNDVASLIRAFRKMAVQMSDIAAWLEDRAHRGAPWTRLFAFLTEKMPRWYDLFAIETDEFIALNPEVEQEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPK9</accession>
    <name>A0A401GPK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0601350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615070.1">
        <property type="nucleotide sequence ID" value="XM_027759269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPK9"/>
    <dbReference type="GeneID" id="38781074"/>
    <dbReference type="InParanoid" id="A0A401GPK9"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="594" mass="67143" checksum="4B32E189FA5577E3" modified="2019-05-08" version="1">MLSLFPTDISLYILSFLSLHDLRSLLLVSRETHHLVADNESTVYHQAAVFHKFVSIRSSLEDALQVESRRCGWLEGAQSWKELCRRWTELERNWDGRGFVHEGGHQVGDSNGMDGVLHFKVDEEQRTIVAVSRSGGLTVRAMEDNRILWSLGNDYIFRARCELSKGFLVFPSSRHGLEIWRRTADVELGSDVIGETVLSPISGPSPAAALDFQFEASKLAASTHPSVNSAMRLRGQYTPHAYLGHPFVNLVRIYRLRFPVLALMSALDRNAVLIFDVCEGVLLRRVSFEAFHPIDKYLSVCLHSAVFMVPWRTSAQDSEGRTRAMVLAETDLPQDLQDASMQLRKVTVPNHHISTRHSDCRVDGNVACVPGADAVEQFEIVPPSASTRLANNSQALVPIGAHRVPPCFVSARMSPDGRHFAAVTVFGLLYLVPNFARVERGATSFSEITTRIYMGEWLRDLVWEEHQQRRLVMKAASEDIFIVNLDASFHFPREPMPYELQDDRDTFANVRISHLSDFSNPTLGWARERGVAFNGVQLTRTAVWMVWDRALLDDTVRRREHRRRQREWEDNESTEPRSSPGNGSLCFASFAAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ19</accession>
    <name>A0A401GQ19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615230.1">
        <property type="nucleotide sequence ID" value="XM_027759429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ19"/>
    <dbReference type="GeneID" id="38781234"/>
    <dbReference type="InParanoid" id="A0A401GQ19"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10875" checksum="EBCA4566B9CD8BF7" modified="2019-05-08" version="1">MSEFAGLQMKDYAMFIMELVAAMKVPCTRDHGWAEGLRDHIERARAMHAHLTAEGFKVPLTLESCTEIEDALAAYKSLMAPLPASSMSKKEGKKVIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ46</accession>
    <name>A0A401GQ46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615182.1">
        <property type="nucleotide sequence ID" value="XM_027759381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ46"/>
    <dbReference type="GeneID" id="38781186"/>
    <dbReference type="InParanoid" id="A0A401GQ46"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12231" checksum="F06540139CE7ABAC" modified="2019-05-08" version="1">MEYADGRCPDVVIALLGIVIVADASSDTHDAQIVLSATQIRSRTRSSRCCWSTPAARWRILTGDAWAALEDERGVGTFTAHAHLSEVSTNQRNQRSSPLPALDILRLAERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ66</accession>
    <name>A0A401GQ66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SCP_0602670</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615202.1">
        <property type="nucleotide sequence ID" value="XM_027759401.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQ66"/>
    <dbReference type="GeneID" id="38781206"/>
    <dbReference type="InParanoid" id="A0A401GQ66"/>
    <dbReference type="OrthoDB" id="3227225at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="473"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="223"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="716"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GBE84289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1373" mass="153343" checksum="87CCCB9ECDECB00B" modified="2019-05-08" version="1">MSSTSTHTLNFAKLNDSNYPTWSGEMAAWLRSANLWRLVNGKLPQPKLSGSPTAAEQTKLDTWEANAEKAAGQIYLTVEPDQRTHFAGVVDDPIKIKQPEESLQGLVNKVNAAMQRVKDLRPNDFNLTKLDEELTSMAMIRALPVEEYGTFTSALLQRDILSKDVVTQAFVTEEINRHHCTTSSPKADQALTTASSSQLTCDFCEGKGHTQSNCYAFQNASKKAKENRKEHRSKRGNKANATAAAAVTQNTTQVDPTTVTESAGKASLSDPLQLDADFDWNADTGATSHMTPHHHWLRNYKPLVIPIKLADNTIVISAGVGTVVFNPVIAGKAVRPVEFTRVLHVPRLRNNLLSCLYLVHQKGFRIHIESKFMTFLHSRQTLFVASITENYTAFLNGTVQPAPESAQAITTVPLDLNLWHRFAHHNYTDVQKMIREKLVTGLMLDSKQQPDPICEPCLAGKMHANSFPTSDSHASKPLELIHTDVHGPLPVCTHSGYRYWITFIDDYSQFRVVLLLKAKSEAFDAFKQYKAYAENLLEAKIKAVQDDKGGEYMSNAFIQFTQEAGIERRHTTRNRPQQNGVAERANRTMDNDITAMLAESKLPPSFWEECIASMVHVWNRLPTAVVKGATPYELWYKRMPDVSHLRVWGCTAYVHVQKDQRTGLGPHMQKCVFIGYPAGYKGWKFYNPDTKKTIISEHADFDERYFPGLKCTPDIPPPPPMSFPPADIIPLPVAPVPGQDLGGDGAHVPNPIPGPVASEADPPAPPAPPAPEHPVTPPPPDPSEHHRVPTPPPFEPIDHCPIAQCRVPRNIRPTWKMRTSPPPMQDAESEDELDVIDADADFVEVQFAGLSAGADPRTYKQAMGSPDADKWQQAANEEIVSLMANNTWDIVPLPPGKRAIGSGWVFKVKHNADGSVERYKGRLVAKGYSQRPGFDYTEVFAPTFRQPALRLILALAAAEDLELHSVDISSAFLNGDLEEEIYMQQPEGFHQDSPEMVCRLNKSLYGLKQGARQWNKKLHEVLTKMGFTRLQSDRSIYVYIRGDVRIIVPVFIDNMTLASKSKKALDDTVKELKSYFKLRDLGSTQFLLGIDIKRDRAKHTISLSQRQYIVDMLERYGLSDCKSVSTPMDPGAELSKALAPQTQEEAEYMHKVPYLSAVGALMYLAITTRPDIMFAIGCLARFSANPGPAHWIAVKHVFHYLKGTMDLRLHYGPSDVKEFFLTYTDSDFGGERDNRRSTGGYLVKVGTGAISWSSKLQSLIAQSTTEAEYIAAVEAGKEILWMCNLLTELWYTVSKASTLYMDNQSAISVSKNPEHHGRMKHLDLRFFWLRDTVEAGRIAPVYIPTAEMIADILTKPLPAAKIIYCHEMMGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQD8</accession>
    <name>A0A401GQD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0604010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615335.1">
        <property type="nucleotide sequence ID" value="XM_027759534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQD8"/>
    <dbReference type="GeneID" id="38781339"/>
    <dbReference type="InParanoid" id="A0A401GQD8"/>
    <dbReference type="OrthoDB" id="3048541at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="27359" checksum="CBDBFCACA0A7F488" modified="2019-05-08" version="1">MKDLEKDGTTLVVVAQILDLQEQRSEDSEQRGWVWQRKYVCHNSRQAQPECKQATQHQFMISIPALLVHPLAPSVIRSAVRTSTVPGGMAGVIRSDEPQLLPTSQPTWLLEHSQLEEVLDYSWDSLKPETEEIIRNFALVPSLFTPSLRYKNSQEQLQLVVLDVPEYLSMELKTGDTIVKCHFCPVSLPLKGMRNHVRIHILYSQRDIDEEDILKEVCRNAINRLISLSVGNLPFLTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRV6</accession>
    <name>A0A401GRV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0701650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615894.1">
        <property type="nucleotide sequence ID" value="XM_027760093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRV6"/>
    <dbReference type="STRING" id="139825.A0A401GRV6"/>
    <dbReference type="GeneID" id="38781898"/>
    <dbReference type="InParanoid" id="A0A401GRV6"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="46"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="300"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="377" mass="41809" checksum="E9C4567307FBE566" modified="2019-05-08" version="1">MSSSSPQSFTFVYKHVQGIDLSMDFYLPPVSAFNASSAEDIHIPALVYFHGGALTVGNRQSWFPAWLQRRITAAACAFVTVDYRLMPPATGHDILADVQDVFRFLSVDINPQLRLRYNEHPFILVDSASIAVAGSSSGGLCAYLAAMHASPKPNAVLSMYGMGGNFLTSQYFTPKSEVFFRGRELLDPSQFSEYLYPSSERLSPTADSPLAYHPQTYTIPGYPANSRMLLGRLYLQLGVYLDYYAGIHQPSLSAVLRETVADTPHDARELRRMQFDDVCGVLSPRERVLLPQFGVMRGWPPCFLVHGEADSAVLVHESEHMHALLQEAGVDVIMKVIAGEEHSLDYQKDADDKYGGPGGLFDEIADFLVRQLKGNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSA1</accession>
    <name>A0A401GSA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0702250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615952.1">
        <property type="nucleotide sequence ID" value="XM_027760151.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSA1"/>
    <dbReference type="GeneID" id="38781956"/>
    <dbReference type="InParanoid" id="A0A401GSA1"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="682"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="730"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="869"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="59"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="326"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="588"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="967"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE85039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1335" mass="149750" checksum="B0DDED70085C0CD4" modified="2019-05-08" version="1">MATIQQRPFSKNYSGLINQSVIAGVVIVICVTFYETAKRKRRGRHLGDELGSVESWHFGYLYQGRSWAKRPSPPSPRGWPLSWVRQVIAFPEDRFNELRGVDATLYVRFLLSCFWFALVHTFTTLPILLPIHITFSIGAIPPASMVRASISSLVNTTEGLSLLWIHLLLLIWVTLTWMSTLYWICRGAFSLRGKNILTAPGLAASGPQEEKQLQYFPHLHPQHLFHSSPPLDNDQSNRGLRLRTVMVTNIPPLLRSEKDLKEYFEYYMSRPVARHAIELTTTTQPGFIIKSLAFLFNQSRLIPFYLREKHVTSGNRDLTTSEGVFQSSQPKSQDVPTIDRVVVVRRMTEVASLLERREEVLRLLETAHIKLATKALFAVKEAMYRFSKPHTGPLHAAIAKLPLRNSTPKPTTAALKAESTAGIDGAEGEDRMELLIHTLGRHVSWPSMPQTTPPLLPVSAADSRSQCVWEALLSLPRSTLDVYQPLIHLSTLFRGKTVPSIDYYTAKLDVLTSLITEKRASAIGDYEAMSTAFVTFADPAHARRACKHLAVHPANPLQCLVTMAPSYEDLDWIRLMRPTFKVEFVKDWVVDLGVWGFIIFWIFPVSIFVGLVSIQNISVFWPGLATYLDKHEWGAELLQSFIPTIMVALLALLIPLLLLLIAKKAHTIATLSSLHDRVMTRYYKFLVVNVFVFFCVGTAALQSFLVSLSANSGLEVNQIADSFPTAGPFYVGWLIFTMAMHGGLELALFGLPLVTYLSTQRQVTPRKRAQGIRPRTFNYYYWLPNHVLVVHVLLVFAVLNPLVLPFGLVYFGVEAIIVKNQLLHVYAKTYEGNGRLILIRVVRYSLDGLLLAQTVFLAYMVVLKKTANVAVSAVLIVMTAFFKLSLTRICRAKYERADVLEAETTCGTELATPEVLPTEESANGCPSQNVETRPNRANHVATTTAARWTWRLPVGLNFAYATIPTRPQRAAKRRPNPFRSTYFNPCEDQSKPSSPTAESSPLSRVLDKAEEVIIQPKQRKDSEGLQKFAPVTRHPPHPAWDDEPSLDHPYDNPFYMRPVEDVLWLPRDPLRPLNLDDTIDMRVSLTSQPASGALGTWRQDELIASGISLSMSIRSGFSCLLDDDELSFSSSTIERIGLDGSEEIDLPSSIASRIKSPRRDDDVETTATLRPQSLHLDRRMPSNGSGSRSPILGLDIRRPSAFRVEQPSTFRSFSVGDEAIVTPFSNSLPPSLECNPRDRSVTMGYELGIQRGQRLRRPANPSPSAQHAFESAMPELGGRGQHISNVISTREAVVGEVIMEEVAEARSRLRGEVAESEWAQEPGSWMTRWMFAKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSC8</accession>
    <name>A0A401GSC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase [NADP(+)]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0703110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616038.1">
        <property type="nucleotide sequence ID" value="XM_027760237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSC8"/>
    <dbReference type="STRING" id="139825.A0A401GSC8"/>
    <dbReference type="GeneID" id="38782042"/>
    <dbReference type="InParanoid" id="A0A401GSC8"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="386" mass="43438" checksum="435B6BEB2FBFE284" modified="2019-05-08" version="1">MPKESFLVPAPPPPTNLGRHRQLAPRAGIHVSPICLGAMSIGDRWDTIGMGSMDKAQSFKLLDAFYDAGGNFIDTANNYQDETSEKFIGDWMEQRGIRDQMIIATKYTSNYKRSATDLKQKSHYTGNNIKNMNLSVEASLKKLRTSYIDILYVHWWEWNTSIEEVMDGLHNLVTRGLILYLGISDTPAWIVSKANTYARLMGKTPFVIYQGAWSVLQRDFEREIIPMARSEGLALAPWNVLASGRIRSDAEEQKRRETGENGRLLLTNDWVRTPDEKKMCDALEEVAKQVGAKNITAVAIAYVMQKTPYVFPIIGGRKIEHLQANIEALSIALTPEQIKYLESILPFDEGFPSTICGDGTANRFVFTSAGNFDKWPLQQAIRPAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSK0</accession>
    <name>A0A401GSK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Casein kinase I homolog HRR25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0703810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616108.1">
        <property type="nucleotide sequence ID" value="XM_027760307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSK0"/>
    <dbReference type="STRING" id="139825.A0A401GSK0"/>
    <dbReference type="GeneID" id="38782112"/>
    <dbReference type="InParanoid" id="A0A401GSK0"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14016">
        <property type="entry name" value="STKc_CK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="540" mass="60026" checksum="2FD421A1D30F08A0" modified="2019-05-08" version="1">MAHNYYPPQIGNWWLGDNLGSGFSGSIFRATNLHTGQVVALKIQRLNAECPTNSYERHFYPALQGGLGMPTLWADGTYGKWDYLAIDLLGPSLDSLFRRSGKAVMDLRSVCCIGMQVINRLEFMHSRGVLHRDIQLGNCVVGLPPNDKIIYMIDFGFSKFYIDPATKRHIPDSKVKRDFIGNYWFTSVGVHCRGRVPSRRDDLEAVALMLIHLLTPGGLSWTRNGVPRTDAAHDRLMREKRDTRPEDLCCGLPAEFEEFLRYCRRLKFAECPDYSRWIEEFKALLEYKGQPTSSLFIWPPPDPQPIVQAPPARRSQPVDPAKVEGILNGLVNDMANVHLGERQVLGDRSEVANRVRVTNANAPAAPTGYADDVIVISSDDENAPGKAPAAVRLPKAMHLAKLAQAVPDATDNVALARVVLEFIQVLQENRSRTLTKEGFAVLDALYKQMADPSVYVQPLRTSRPRNSAADGVEEGPEPRHVKTNKLWTLRRNAAAAKSNKALAQLVAEFGTVINRSSGRTVTKDAFGFLDALSGRLRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSM8</accession>
    <name>A0A401GSM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616154.1">
        <property type="nucleotide sequence ID" value="XM_027760353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSM8"/>
    <dbReference type="STRING" id="139825.A0A401GSM8"/>
    <dbReference type="GeneID" id="38782158"/>
    <dbReference type="InParanoid" id="A0A401GSM8"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="267" mass="29893" checksum="B841B139C7CE9159" modified="2019-05-08" version="1">MANNPEDTWSASTYNTTASFVYSQEFTTPILRLLDAKPGERVIDFGCGSGELTLQIKQLVGDTGMAVGFDSSESMIMQCKANGVESAFVGDAQDLKFPSEWSSDLQGGYDAVFSNAALHWCKRDPAGVLESAKRVLKPGGRFVIEMGGYMNCVGVRSALCQVLRTKGYHPDELDPWFFPTTGYYKSLLETHGFHVTSISLHPRITPLKSSLCDWLRLFSRPYWMRDMGDEEAEEIMRTVEDICSVDCCDEQGRWTIMYVRLRVVATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT77</accession>
    <name>A0A401GT77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerol 2-dehydrogenase (NADP(+))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0706120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616338.1">
        <property type="nucleotide sequence ID" value="XM_027760537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT77"/>
    <dbReference type="FunCoup" id="A0A401GT77">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GT77"/>
    <dbReference type="GeneID" id="38782342"/>
    <dbReference type="InParanoid" id="A0A401GT77"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="90"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="373" mass="41662" checksum="9D0B6BF5181B6DE0" modified="2019-05-08" version="1">MAPAYKLLSTADPDEAQPESTSKPRRTKKLLFHFVAAAAVMYAVFYGVRLLARSSKRFGSGCRTGAGMRNLSSLPTHYTLPSGDKIPSVALGVWQAGQGEVGAAVKAALSAGYRHIDGAWIYRNEEEVGQAIRESGVPRDELWITSKLWNTFHAPEDVEASLDESLQKLDTEYLDLYLMHWPVAFKKGTTTLDPELTANPYPTWQKLEELVDKGKVRNIGISNFNIARIKNLTANELKYKPAVNQVELNYFNPQPELLEWSKENGLLLEAYSPLGSNKQVKEALSLPEVTAIAKQLDITPAQVIISWHVQRGTIVLPKSVTPSRVEENYHIYALPQDLFEKLEEAATSHPPQRVVNPSKGWGLDFDVFDEYPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTQ3</accession>
    <name>A0A401GTQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616499.1">
        <property type="nucleotide sequence ID" value="XM_027760698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTQ3"/>
    <dbReference type="GeneID" id="38782503"/>
    <dbReference type="InParanoid" id="A0A401GTQ3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="692" mass="74358" checksum="88F501CABF9CE179" modified="2019-05-08" version="1">MPPTSVKKPRSGRRLGANGAEGVARESAQVRHNLAEPARSIVSVATLAEPEAVDDGLEDWEDDVSPLQGRGNRTPWTPSRPPKLPSLSTVARKPLARSAVPLPERRSTFGPRGYQLKVFGKDDLPGASQETGRLDVIKTRGATSSAANALPLAGSVGARTSETPAPIPSSVYVLISKQDHKRKRVSALQIPSVAGHTSENLISSSVTAHTAAESHIQPDSSADAGVHTRSNGLMEAINSRAVADTGKQQTSVAAITASEIPSAQQDRTLVAPIAVKKRRGRPRKTDTLIPSPSVVKRPRGRPRESAPAALPAPALASQDQRSLLSPPTSISIAAITGTAAVTSPQKRLCSHISCQNALLPFAEYRFLLCEKCRERGRRNYHKGKKIFPERLGHIRAAGEVQGLSSEERTGKRRKTITSVLSDGNPANAASSENNLGRQDKRVLLSHSDTLPNRLEQEEEGYEKAKHEEEEEAVGNVEQPSNSAAPGSSKPAGPAKWWLDTVNLTWRRVSEPTSIPPTPPMRSLANHITASTEAHPCEFESLAELCLALTAAYSSATTLMTRRVSKSGILNFADGSQGDSNGLLQFYGTTTVIKDAQVIADEQYVRDLTEEIVYGSGIQLGVRMDDEYVTFMKRGKVSMVILLCECASSGPNGPGKGKLNKCGGHMGVSIEEEHPNTESEQETVLRIKVEMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU69</accession>
    <name>A0A401GU69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0802890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616680.1">
        <property type="nucleotide sequence ID" value="XM_027760879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU69"/>
    <dbReference type="GeneID" id="38782684"/>
    <dbReference type="InParanoid" id="A0A401GU69"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="61" mass="6966" checksum="FB393ED47101CDD2" modified="2019-05-08" version="1">MSQYSHLSTIDPEFAAIADQLSRNPPVDDVVARRRPTNGILQEYLKSYLPAGKFALTLYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUK5</accession>
    <name>A0A401GUK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0803910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616782.1">
        <property type="nucleotide sequence ID" value="XM_027760981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUK5"/>
    <dbReference type="FunCoup" id="A0A401GUK5">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUK5"/>
    <dbReference type="GeneID" id="38782786"/>
    <dbReference type="InParanoid" id="A0A401GUK5"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 4 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE85869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="435" mass="47237" checksum="B6150C8F9861916B" modified="2019-05-08" version="1">MSTSALPPLNPLLQVCGKRTRDIFASCPDDSMAENEKSARIRLSVRMNDEYKDVRELPAALAAQQGPVGPARPKEQRKAITAGPATDTSRMIATIDNKPPPQPSTFASSSNLSKALQLHKTTRTIKPTYHPPWKLTRVISGHLGWVRSVAVEPGNKWFATGAGDRVIKIWDLASGELKLSLTGHISTVRGLAVSSRHPYLFSCGEDKMVKCWDLEANKVIRHYHGHLSGVYALSLHPTLDILVTSGRDASARVWDMRTKAQIHVLSGHTATVADVKCQESDPQVITGSMDSTVRLWDLAAGKTMVTLTHHKKSVRALAIHPTEFSFASASAGGNNIKKWKCPDGTFVFNFSGHNAIINTLSVNSEGVFFSGGDNGTLTLWDYNTGTAFQNMDDIPQPGSLEAEAGVFCSTFDVTGTRLITGGADKTIKIYAEQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUV7</accession>
    <name>A0A401GUV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Early meiotic induction protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616930.1">
        <property type="nucleotide sequence ID" value="XM_027761129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUV7"/>
    <dbReference type="STRING" id="139825.A0A401GUV7"/>
    <dbReference type="GeneID" id="38782934"/>
    <dbReference type="InParanoid" id="A0A401GUV7"/>
    <dbReference type="OrthoDB" id="2017405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15203" checksum="88F9269047490D47" modified="2019-05-08" version="1">MSTVDFETAVKQEEEYLRRVHPTADDIPGCMKLFDDFLSCNIVGSQVKSLYRYGQMSGCSPKLEDFKFCMSIKGLHPERKRDMWIRRRAEWWAARRLGKSSEDVWDIRTEPLQNFPPARPAVASVSDNTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV30</accession>
    <name>A0A401GV30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0806020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616991.1">
        <property type="nucleotide sequence ID" value="XM_027761190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV30"/>
    <dbReference type="STRING" id="139825.A0A401GV30"/>
    <dbReference type="GeneID" id="38782995"/>
    <dbReference type="InParanoid" id="A0A401GV30"/>
    <dbReference type="OrthoDB" id="2446696at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072:SF42">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="192" mass="22245" checksum="5296CD776FC9F217" modified="2019-05-08" version="1">MMAKKPIWEWIPNCQQVFDTLKAKFVSAPMLLMPDKMKPFIIESDASLVATGAVLRQTDVNGDLHPCGYLSKSFNPAERNYEIYDRELLGIVRTLEEWCHYLDGSLHPIVIHSDHKNLTYYRTAQKLNRRQAPWSLFLSQFELQLVHVPGMQMIQSDTLSRLLGKGDRDHDNEDRILLPEALFMHSISTQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV62</accession>
    <name>A0A401GV62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617040.1">
        <property type="nucleotide sequence ID" value="XM_027761239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV62"/>
    <dbReference type="GeneID" id="38783044"/>
    <dbReference type="InParanoid" id="A0A401GV62"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="148" mass="15715" checksum="F37248CAED601C38" modified="2019-05-08" version="1">MGLLVARWTRNPDTHTQPTEPNGGGPRPPEQNGSDRHTVATSSSTSDREGEAPSLYPLIHARATARGHVIVDVDTVTDTHPPLSALSPLRIPRRHAPWRIRSACPPRGTHGRVEEGSSGGDVAHIEHRSGGPGSDAARLLSPTLAGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVP7</accession>
    <name>A0A401GVP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0901740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617208.1">
        <property type="nucleotide sequence ID" value="XM_027761407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVP7"/>
    <dbReference type="STRING" id="139825.A0A401GVP7"/>
    <dbReference type="GeneID" id="38783212"/>
    <dbReference type="InParanoid" id="A0A401GVP7"/>
    <dbReference type="OrthoDB" id="3341077at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="16041" checksum="5A75B57291F6FEE2" modified="2019-05-08" version="1">MLSFFRCAPSSPQSYAAWLLYTQKRTSTWSLTMCTNLSCCVLIIWRLWRVHSQVMSLVEQSEKRGLKWFLSVFIESAVLYVFWTVLFIISYEAYTSRNNLAFLVEDAWAPVSGIAFMLINIRVGLGYAMHTSVQRSSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVQ2</accession>
    <name>A0A401GVQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0901420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617176.1">
        <property type="nucleotide sequence ID" value="XM_027761375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVQ2"/>
    <dbReference type="GeneID" id="38783180"/>
    <dbReference type="InParanoid" id="A0A401GVQ2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="83" mass="8610" checksum="6771A3AEADE62253" modified="2019-05-08" version="1">MASNVYAASCFALEAWNSQQITPIQPEASPSSIGASAAGQSSPAIGPVIQSRACHPSRATASFQICPKSLPARWLIPPSTLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVQ7</accession>
    <name>A0A401GVQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0901840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617218.1">
        <property type="nucleotide sequence ID" value="XM_027761417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVQ7"/>
    <dbReference type="STRING" id="139825.A0A401GVQ7"/>
    <dbReference type="GeneID" id="38783222"/>
    <dbReference type="InParanoid" id="A0A401GVQ7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="573" mass="64310" checksum="8DCEA315DFB43512" modified="2019-05-08" version="1">MAGKARWSKPYGSMMVLYYPKWRDTRANAKGWDRPKVNTQQIGNWFANNKAALDLGIIPGTTDRKFSLTDAERMANDDDYPDPTEGEGGADPATVDDNDVEPFSVEEDAADVRKKTMGQKWMGEDFIQTVETKMGGKVLILLALLTEKPTQIRRIKLQSPDTGGFLKFTDSVDDWQKDLWKKWGMWAMNVMIPDELKDNDAEEEDEIALTDVQHEIDDDGNAIVPAFEETWKLTQKRHLVRAIVTHQHRKIVDSKRAKCPWKKISEDVRKYIDEACWPDSMVFAEPWNIGVDNIDLLLKHWANRQAIGSVAFQFLVAAGGGDAVKPRGKKQKDVTDMNVGNSADEGDQDDNDNEMEVGVNCHTKGKGKQPAIRKKHVPPHSEEEFDLDNVSSSEDDLVGVKMKAAMNKAKSMHTANTAYNEEGWQPFFAQDLVDVPRMGDASSSGVAGAPAAIAHARKLYPRIANHPEDIILWPRSMMVDADWYKHNVSRIVIPLPAFSLPDPAENDAAELEWVDCQKAILLTTSARFQGFRILDLEHIVQRPSMARLDNPGCFAPRLLADDTAAIPEEYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVZ3</accession>
    <name>A0A401GVZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0902640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617298.1">
        <property type="nucleotide sequence ID" value="XM_027761497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVZ3"/>
    <dbReference type="GeneID" id="38783302"/>
    <dbReference type="InParanoid" id="A0A401GVZ3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="10915" checksum="02CC729F3BB2B193" modified="2019-05-08" version="1">MQPSSVCNLVAGLRRYAEPDENTDFHVLGHNYPVESAGEPDRVNSSSHSLLCAQISMNGARSVSPLEALKPIPIQALNEMKQKNQRITGFRERLPTDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW13</accession>
    <name>A0A401GW13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit alpha, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0902510</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617285.1">
        <property type="nucleotide sequence ID" value="XM_027761484.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW13"/>
    <dbReference type="GeneID" id="38783289"/>
    <dbReference type="InParanoid" id="A0A401GW13"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="896"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="1250"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE86372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1379" mass="147668" checksum="4A9B06138DE486AF" modified="2019-05-08" version="1">MSIVSKIASPPPRNTAVKMKPGATTIHPSIGHARSTSTPVSVSSSISKRPVDVDKKAALPAGGTKLSTPGLSNPKVAGSHVAKASVGYVSTMKRASSLPIYSKMSPTAPVSVPRSPPSTTARASFAKPTKASVNRTSLPGAFGTPVRRTAICQPKPVRAGSPPAKVLSKAATASDKEEAVAKDEGAEPVVVAVVEEDVGDIHITVDAVVENTASPTALKAKSQKVDGLETAKCRPVSVAAKKPPPPFPKRKVGKENYLTVPEWTYGFETPKAVTTKKKVNAEKKPPRSVNGSRFVKPLRSRSVAPSPPVKVEAKPSRAFKPTLGGLAEEESPSETGKSATTIMKTSPPVHAGTVSSPARLVTKSPAEKPLPAGPRVTAGLIEDVLALNRLFSNAAFSADDEKLGQKDDNDIGNAGGTMVPVKPIVVDGDIGNAVLKAFEHAPVSASIKSVRNARLVQPSTVEYISPDLLVNEQSAVVEYWPPVGHDAPVAAPVPIVNVASKVNKDTSFPAVWRLHEQSSERLMSKMKRSYDGPVMMAEVLEEIAEEAEVEYELEAHVGTGTTSPPEARSAPAVKAIATPRAERRYGMVSPRTLQKADSDGTPAALLALASKMTPTSRAERRYGMVSPKPLQKIGSDCMPEVQFIPAFQATAIFRAEHRFGVISPKAWQKTDSEHMEVSGILPTLEVQIDPCATSGKILPVEDGVSYVVQSFLEPAIRAPQKMEKLGPMSSCPPQADLHASFTEPFAEDYEASRPSWDVSSTSSSSTSSSCSFTGLRSAWSDWTVDSLRSGHKRRRAEEGNWGGVRTRDYVTEGRRLPKKPYAPTVDSFVYSTFPPSSMHRVALRNSLRAAALAAPRSAVRVAPAVSRSYATAKAAASEVSSILESRIAGSSVGANVEETGRVLSVGDGIARVWGLRNVQAEEMVEFSSGVRGMCLNLEADNVGVSIFGNDRAIKEGDTVKRTGQIVDVPVGPELLGRVVDALGNPIDGKGPVKATQRSRASLKAPGILPRRSVNQPMMTGIKPIDAMVPIGRGQRELIIGDRQTGKTAVAIDTILNQKRWNDGQDEDKKLYCVYVAIGQKRSTVAQLVQTLEENDAMKYTIIVAATASEAAPLQYLAPFSGCAMGEWFRDNSKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNEKFGGGSLTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFFRGVRPAINVGLSVSRVGSAAQTKIMKKFAGSLKLYLAQYREVAAFAQFGSDLDASTRFLLSRGARLTELLKQGQYQPMAMEIQVPIIYAGVNGLLDPIAVDQITRWEAEFRSHLTATQGPLLQEISAGQITPEIEAKIKKVVEDHVSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXL6</accession>
    <name>A0A401GXL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1002020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617870.1">
        <property type="nucleotide sequence ID" value="XM_027762069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXL6"/>
    <dbReference type="STRING" id="139825.A0A401GXL6"/>
    <dbReference type="GeneID" id="38783874"/>
    <dbReference type="InParanoid" id="A0A401GXL6"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="7">
        <location>
            <begin position="94"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="436" mass="48518" checksum="5BAB7106E4152CD8" modified="2019-05-08" version="1">MATNISPSENDLKQALIDLRASNPTLGISKVHALLLSTHTTWTVSEKRTKKVLQSEGLVLSSSAAKNAGAESCGGVIYPSSRILKGLDISKFTRKVEVRYFGKSKGKGLVAKVKIAEGETIWKEDPFILAPEWELFDLQVSSVACAHCSTPLRDSPLVIPCRATSSSATSCTAKFCGRLCLSRSARIHPLLCSSQNPASVVLLAFARKSRWMSLHALVQCTARLMLTYQQDEASFWVDWEVFRGLARLSMEERAKGEWMKGVGPDRDTWKKAYMLYVHAFREPPSAYDKKKFAKLVKRPLPEEIMHELFDYDAFLCGLGSMSLNLESHGGLYVLHSHMNHSCSPNISARHNEQRTALSRITAIARRDIEPGEELTLTYVDPSRGVKQRRSELLEWGFGTCQCERCRAEIEVASQQDASAVHEDDLEKELKAGLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXM5</accession>
    <name>A0A401GXM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase AflY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1001630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617832.1">
        <property type="nucleotide sequence ID" value="XM_027762031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXM5"/>
    <dbReference type="STRING" id="139825.A0A401GXM5"/>
    <dbReference type="GeneID" id="38783836"/>
    <dbReference type="InParanoid" id="A0A401GXM5"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57612" checksum="0EB3FA3B328AAECF" modified="2019-05-08" version="1">MTTTKTNLDALFPAPYPPPSPLSPGRWPGITQDSTLALGRLLKENHEKWHIFFNDMHFHNHTSHHLLAIYYLGASPDLLDAAYQTHVSRMRPARKSPDPITSKNFHQHLGDENFYSGYLEFFSAVLLEKGAAATIEEYIFSPYANILAPELGKPPMKMLNRFLSGIFHPLIHTGYGVEFGLPGMVAEGLAQTAVHGPGGLTLVRPSLFQYASSISSDVINAAVNRLTKLMPSLVLESAQHALRFQHKPAQDGVHALTILSRILHDPAFSLAAIGLPVPDDSEENAFEHVVRVRGEAIVAHAEAWSVDGTSPEEVARKTEEIIWMNVMLYGVCGWSAREKSTNGKFKPDFFFMHMVTSVLFLHSLTAYLTPTSSTILLRTYLINALTWWVARGRPAPPLRAFFSSPDAPTAHPTEAGAHPAPARDALVRTDPSPNPWLPLLQTTLVHPDEHLCKLQRALAHFAALYGATPKGHFAALAEGDAPLEGAGEMDGTLFVRAAGLTADALGWMREGDERRSWDFGGFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXP0</accession>
    <name>A0A401GXP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1002340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617901.1">
        <property type="nucleotide sequence ID" value="XM_027762100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXP0"/>
    <dbReference type="GeneID" id="38783905"/>
    <dbReference type="InParanoid" id="A0A401GXP0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="148" mass="17077" checksum="EAAD9FFAB3B71C78" modified="2019-05-08" version="1">MPGLPERRPNNNRRQYYGFLLPTADKFFFHYCEIKSVPLTREDGVRLDPFWMGWKSFEKAVGCLTLPQNVILGEDDSKETEFDGEAYCLALASDPKLSYLKGLNPMEEQICTIIKELNECGVAVTRSDLLWYRGGIYEDILWMPDPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY37</accession>
    <name>A0A401GY37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1003640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618030.1">
        <property type="nucleotide sequence ID" value="XM_027762229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY37"/>
    <dbReference type="GeneID" id="38784034"/>
    <dbReference type="InParanoid" id="A0A401GY37"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="412" mass="47188" checksum="E25D6760A71DE253" modified="2019-05-08" version="1">MEAIATLPNLLDIRFLFLPSGVFQDFARALKSTPMRLTLFDIDPDMVSEDNLVSILNYMRPSDSEIAVPEPRCANEGAVDTGERRPLPSLSCLQSLYVSLLLNRPRSSLEQPLAHRLAFPAINEVALVNGFLSTDVAFQAFRNVRRLTLRLMRMPSGAPRTTQWKDLDYLNASPLSFVAWTITIPVSWLELDLDLCYRMPELPWVELRPVAVTVHRDIRDFEKERDLFWQTLAKAMSEAHTVRSFELTLTMDRLPRDLGNVEDWEDVSFLRAAVSTILQELADANVPLMYLRVFCVLTGLENGDDVRDDAAVDPVGLIPQEVQKCLPGVRYLSLGVGKWHEYDSTMRLPVNDPKWRYSWWRFSENDEKRRMPAAVGERLRKEMFGRECDFESLAMRELELSTELGYADGLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY95</accession>
    <name>A0A401GY95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1004330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618099.1">
        <property type="nucleotide sequence ID" value="XM_027762298.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GY95"/>
    <dbReference type="GeneID" id="38784103"/>
    <dbReference type="InParanoid" id="A0A401GY95"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="497"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1214"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1146"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1385"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="909"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1166"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1387"/>
            <end position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1545" mass="170398" checksum="9F6A712DC21868AF" modified="2019-05-08" version="1">MSSPDASTSTNTSQLLFLPTASINKSQTSLTLPDVSREDSTVTFDVSMHSELAKADISLAPDGSFVETSSGAAARELKRRFDEYHGVGKDVRSPYAITAIVNQHGKQMYRLGARNLSAPAAAAEEAELRTSKYTTSSTIPSQAISKPPQSRRRSRMSVHSFLSSAVFKNGPAPVLPPAISQQDGSRSPPVRKLRKTRSIPNLVGVGSDPSSSQAKPQAPPTGRPHAHSVSSADAFRPSPPVMKQEEKLAQRDIFADTMSWHSVPTSPLGSSRTSFSAPSLHLPRDQRLDPFDHGKTSGAILSPFGPCVNFESPSWRPSSALSVPPALREMQSFESVMTARADSRPRSPRSAIRTHTVDEESTDEPQMTTLPENETPASKPVVPLAETTFHSRYSTDVFDVLQTYRGLPVPDKLSPTVLETTIKLSLKAEESAVPRDDPRFVIWGDVEADDPDDIPQDSTTDLSSAHSVVSRKKNAKDKSISAQPDIPPISLSSSVGPKRMMLAATIERWIAQLTSELDYDELLIFFLTYRTYVSGVDLGHLLICRFHWALGEPTSTHDEMVRRIVRVRTFTAIRYWVLTFFNVDFVPDRELRLLFANWLNTLRRDPILQRHRDALKIVRQLKKVFLDCKDVHLHKGKRTIHRQPRQPETPIPQPSKLGDLSNGHFAESLRRAIEPEDSDIDLEFDGSDFLNAQNFGIGASPDTVVGSGGPSDALDLVMLRQPLHFAFTHTHGRANPILQAPYPLPAPVILPVSHSALSRALVNTIGRLGRWKRVLNARNTRTPLNMPLNMPLNMRVDVSAFDVEPNETGDLLLVRGGFEQYLKMVESQIQANTTMLPHSSDFVPSAMSIRDSVTIAESTFDTPPDYFQPGEDVSTAVQPSYPTLDATRLSTPSEVGDLSTTSEFISATSEPLESPPFSSERASPGPMSTIFSQQIDVVSIDELDLSDLSSDEDLEPVVPPGLKRPPRRLPNRREFEFVRHSADSVSSMGIRTSESLLSGGSNSSAGPDMGGPIEQWQVDALVDSLSDEAEDGDVEAALRRLEGQINQDKQRAKQSKVDKWVQSIQERRTAGQSDARSSHNSSDEDYGEEVEHSQIQDSSQSGSYSSSLPSTSLSSLHSSLDSTLAPETATTESWIDSLVSDRATISATADTKPSVEDAVPAEILNSRVSRPSTPTDPTPRNLTAPPPTAHPPPLSRFIHPEKIKWHCSFIRSYRTETLMHHFSMIDRELFLGIKFEELVSPHLSGMNEEANIHDWGQFLRQRARLKAEGRDGHQTGSLTVVRGRFNLMANFVVSEVVLTHPSERAVVFNKFIRMAWEAYRLKNFNALVAIIAGLRSEWATRAMGKMLNRVGFRESRVLEDLIAWTTNAGDFKHIRRTVDALSEAESLPTNSQEISINTDGQTSTTRSKVPLENKPPPPIPACVPFFGIYLSQLYRYSHLPDLIDPTAPDESVGIDPVSNSFEPPAHPEVFSSLMPLPPSIQLEPLINVHKQRLIAGAIQSLVAGQHLASKVQYPLDKKLFQKCLKLRGLDHATLERALALSPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYH6</accession>
    <name>A0A401GYH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1002400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617907.1">
        <property type="nucleotide sequence ID" value="XM_027762106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYH6"/>
    <dbReference type="GeneID" id="38783911"/>
    <dbReference type="InParanoid" id="A0A401GYH6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12489" checksum="E9B37CB7ED48E052" modified="2019-05-08" version="1">MKVFADPAFWSKTVWCRGVVEQLEHRYLQQENARRARTMRKYDHAFVCVASTPTTVIPPGMDGEQLANAVSHLADYNQLPGERQPASIPLSVIACIPPSTYCYNVVLNHSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZG7</accession>
    <name>A0A401GZG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome recycling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1102250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618461.1">
        <property type="nucleotide sequence ID" value="XM_027762660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZG7"/>
    <dbReference type="FunCoup" id="A0A401GZG7">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZG7"/>
    <dbReference type="GeneID" id="38784465"/>
    <dbReference type="InParanoid" id="A0A401GZG7"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="97"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="249" mass="27766" checksum="B857727674F6991F" modified="2019-05-08" version="1">MSFSQANHRSLARLCSSIALHRPVASASSIRLPNSRSFASRKPAGKEKNSKHKVTTDDLIPGSQLKAAGEEYTKAEERMKAILEKYRKDVVALEMRASGRVTPAVLAPVRVLLKGAEKAVRLEEIATVGVREGTMLIVTVFEEQSLKYVEQAIYDAKIPHVIPQKMDNRTIKVPMPKPTVESRNEMLAAAQKQAEDARVHIRKQQQASLKKGNYTKYSPQTEEIQSLTTKYLSEIDKVLADVKKSTVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZW5</accession>
    <name>A0A401GZW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 10">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1103930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 10"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618629.1">
        <property type="nucleotide sequence ID" value="XM_027762828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZW5"/>
    <dbReference type="FunCoup" id="A0A401GZW5">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZW5"/>
    <dbReference type="GeneID" id="38784633"/>
    <dbReference type="InParanoid" id="A0A401GZW5"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="552" mass="61367" checksum="B33C5E93F7ECB191" modified="2019-05-08" version="1">MSGRLASDYSAWKQLQQLYDTQHSKLVLKELFAQDPSRFSKFSREYVSPDDPSVTFLLDYSKNLITQPILNTLLSLAREAQVETFRDKMFAGEHINTSEDRAVLHVALRNFDEFKISEAGVDEVSGVLAHIKEFTEAVRSGAWKGYTGKPINTIVNIGIGGSDLGPVMVTEALKAYSKRDLTAHFVSNIDGTHLAETLRVCNPETTLFIIASKTFTTQETITNATSARDWFLGTAKDKAHVAKHFVALSTNTKAVTAFGISEANMFQFWDWVGGRYSLWSAIGLSIALVIGYDNFEQLLKGAHGMDKHFKTAPLEQNLPVLLAVIGIWYNDFYGSQTHALLPYDQYLHKFADYFQQGDMESNGKFVTKGGQRVNYQTGPIIWGAAGTNGQHSFYQLVHQGTKLIPADFLAPATTHNPIANSLHHRILLSNFFAQPEALAFGKTETEVRKELGPNASEPLVKSKVFEGNRPSNSIIFPLLTPSTLGALIALYEHKIFTQGVIWGINSFDQMGVELGKVLAKNILAQLEKPDDVKGHDSSTTGVIHYYQKHRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H094</accession>
    <name>A0A401H094_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1200530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618741.1">
        <property type="nucleotide sequence ID" value="XM_027762940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H094"/>
    <dbReference type="GeneID" id="38784745"/>
    <dbReference type="InParanoid" id="A0A401H094"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="397" mass="43144" checksum="DB33C45264001544" modified="2019-05-08" version="1">MHTESDAHPECKSDGRYKREKVCVSSRSPLNIDLDIQAVVAHTPSSTIHPVAFLSTYLLDSGSDSARGRQSISSPYVSSPGSLPVQHAASSSGLGSVSNSGSSSNRSVLSRYDFPSLSASKPHYTQSSTKGPSQDITLSNDILRYARPENITHETNLVASASDIPLPPSSFGTMPLVYPHRAFDRISPSAEDSHPRTGYDSERIAPHARSYSDMRPSPVRPSNTFHGTTPANRGTNRKGTQKSRAAIRDSASSSARPEGDFHRSNLNTHDSGVRQDKTTTSPCLTCFPPLKCEEVPPNWSTTCPYCSNIIEETYLPEHVLIHKEFFAPAFCGGLPRSDAIKVGVNLKMAKKFEYKGEVYYGGCLQNFCHTPALVRHLTGQEGCVGNPNAPYNLAMQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0X2</accession>
    <name>A0A401H0X2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1202810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618965.1">
        <property type="nucleotide sequence ID" value="XM_027763164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0X2"/>
    <dbReference type="FunCoup" id="A0A401H0X2">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="GeneID" id="38784969"/>
    <dbReference type="InParanoid" id="A0A401H0X2"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="59"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="343" mass="37216" checksum="3CF1EAE8B67E05A2" modified="2019-05-08" version="1">MAPVTNGRLLFKEIPTGYPVPGKTTVYDTSETIDLESVSLRGGSLVKVLVLSSDPYLRGRMRDVTIPSYSSAFPIGKPLDNLGVGVVLRSEDPAFKAGDHVYGTLPFEQYTIQGRGARLRVLKNEVKIPWSTYIGVCGMPGQTAYCAWKEYAFAKKGEVVFVTSGSGPVGATVIQLAKAEGLKVIASAGSDEKVAFIRSIGADVAFNYKKESTLEVLRKEGPIDIYWDNVGGETLEAAIDTATVGARFLVCGCISEYNGQPPYHVKNLNLIFAKELKISGFIIFNILAKYEEQFYAEIPKRVASGEIKYLEDVTRGLENAGQAILDVQKGLNKGKKVIVVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H143</accession>
    <name>A0A401H143_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nonribosomal peptide synthetase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1203640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619047.1">
        <property type="nucleotide sequence ID" value="XM_027763246.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H143"/>
    <dbReference type="GeneID" id="38785051"/>
    <dbReference type="InParanoid" id="A0A401H143"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="897"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1954"/>
            <end position="2030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE88134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2563" mass="282271" checksum="93166EB272AC9518" modified="2019-05-08" version="1">MSTTAYEENRRILADVLAYYDAKSVEELNTNDDDAFWSEKMWESWKFIFHDNGCYSQAFDMTKPKDGVFPVVEHFAGERRFYRDEAGEVAHEKRFFKESGEEHKAYVISKSENLFEDGLAMLPEGPMMATVRLFGYPPYGHGTCAVNQMKWGAPVVSQISLQPNEQIRLSVLPLFMAVPGAKGPLLKTIIFRDESDAKPFSKSAHWAQDGAGAVIRKVDRAEAIKTIFPDAQSAHGFVMRPEMVKGCRLRVTDGVVFDVQALSEGGDDAQFFALNEKNVLLNVVQAPEQGKPHALKWRLLWRVDKRLMVGVIAYNAETLKPEHEAHDKSIHGAQWDPRTDRCCSLLLSLPADTLSFERRGPDDQHFDELGDLARVVSFSGVLDLPQVLHQFHADAQRGIHTDFEAIARTHPDRIAVELGVTDVKLTFRELDQLANHVADQLLLAGIEREELVPVIASRTPQAIAGIIGIVKAGGAYVPCDAEEWTQDRIDTVFATIKPRVVVVSDPGFATLVPAHMSKNVIYTEASKAIAPSSGQVVPSSNRLAYVIMTSGTSGAPKGVMVDHKNLIQYAHRSEHAKPGNMGVQPGDRCFLVFSVAFDAFSGALWSCLCNGATLCLADKSSIASVAKHASHVPLTPSLLSSLSPGEYPRIRGIFAGGEALPLSLVQSWAREGLRIFNCYGPTETTCAATMIEIHADSQQVTIGRPLVGYAVLVVDENMKPVGVGVSGEMVIGGRGVARGYYANKKLTDEKFVELEWVEKTLGIKGTGKWYRTGDLARWTADGTLEYLGRSDWRVKNRGFLIDLEGDVESAMLNDDTVSDAKAFMIRGRLIGAVTPANVDAKALRERLLMHTPAYMVCNKIFALDTFPRTSNDKTDRRGVQALIEQLLEEDSTSYGPAPANEAQRAVAKGFRALFRLHSEVGVHASFIELGGDSLGAIRLVSLVRASGFSITFLDVIGLNIIEAIAAAATPLSSAPSVSKEQATTDEDEALLREVLGPDADVLAEDIAPLTPVQRGMFMTTATKPTVYSIQTRSSLQDLDGPFDRARFVHAWRLAAQRHAIFRSSFHLEHGSSGVQIVHRRIPELNYSLREFESDADLEAALGAYVEEDLKTGFSVDDFVLPGKLMRLALFVSSQSNTASFVWTVHHGLIDGLSATVLHDELIQDYNDSQRPLSPARSFASVARSIVRKQSDLEEKVTSFWKESLKGAEPVAPINLPCLLTSAPVAHEIVYESSLALDLVAEFARQSSVTMTTVFIAAAAVVLCRYTNKRDTNIGIVLTGRSTMFDAERVVGPVVNTLPIHVNLEDDSLSVRDFVKATSKQVMSLTSWEWASLRSAMTALDIPADKNLFDFGFSFSDDFASEVTPSSGATGLQMLNSVTTEQTEFPFTITFERSAKQTAIVRFRQQPQRIHETYAQNMGRHFCNAVTSFMSASLVKGVQLTDATERQFLTHGLNSHHTEVQRQTVTILDRLEQSMTAHKDLDAIAQGTASMSYAELDRQSSAVAYYLASHHGVTVGSTVGILAMHNFEWLIGVCGILKAGGTYLPIDAKYPLERQTWILEQRDNVGILLVPQATERYRAMFKVKLLRVAELVEAKTPPVSLARPTTQDVVVYIYTSGTTGVPKGVPMLHGGLDTTFMSDYGHLWAAPGRRVGLMMALGFDGHLMCIFGPLLYGGTVVLQDPDDPLEQLKHVHCVMCTPSTLASLDEAEHKNIEYVVVGGESVPQGLADTWSVGRTVGNMYGPTECHIAVTFKYLTPGEPVALGRPFLHTRIYCVDPDTCLPVPVGLPGEMWIGGSSPTSGYVGRPDSTNEKFIADSFGYPGERIYRTGDIGRWNLKGELEYVGRMDDLIKLKGGFRLSLVGVENALIREASNFMGTPLATATVVLVNDRLVAYVTPGSINTGSLRERLMETEPHFAVPKWIIALDNPPMTANQKIDRKALMARPLPQDESRDFQPPKTETEQHLAEIWKDMLDTSEDVSAMAHFLRLGGTSLNQIRLVSALQRLYKIKIPLTLVIIHPVLRDLARAVDDLLATTQTVTYSAVEVTDIGVLSHSERGMWLGYQLATVKTPFTVSALYTIKGAVDVDLLKQAFDLVIARHVVFGARYTVDEKGEPRRETSGPSPQALIVSPQDFNDTLHTNLNYVFDISAGPLVRVRLSSKDSTTSVLFAANHIVVDHWSIDLVMKDISNVYTSMIRGTYVTPSPRELDYPIWAASASRKHEPEMLAFWGSYLRGIPDCIALPLSRPRPAMKSYAGRSRFFDLPEELRQIVERAAIAVGVTLHQFFSAALILVLSVFAHQDDIVVGASHANRRTAEEYELCGLFLDRVPFRHQLHDGNRTSTEKLLRSVVDSQRAASLHFSVPFDEIVRHVGTPRNLGRHPLFQVMLSVENENETIPKLRIPGAEVESVMVAPEGSNFDLLLGYQLLPKRQGMRLRFEASDIYDDSLVNALETAMRTSLAMLAGSSSTPLQICAALDAYVVRAPSCEDKMAVVRCTMLTVIDATPSGVRQTSPGSDVTFFELGGTSLMVPMLLKELELRRVRISFIEFFLDPSISGVASRASFELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1N9</accession>
    <name>A0A401H1N9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SCP_1301240</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619222.1">
        <property type="nucleotide sequence ID" value="XM_027763421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1N9"/>
    <dbReference type="FunCoup" id="A0A401H1N9">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1N9"/>
    <dbReference type="GeneID" id="38785226"/>
    <dbReference type="InParanoid" id="A0A401H1N9"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="245"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="823"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="758"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GBE88309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="934" mass="104176" checksum="712BF0AAC7A2FB53" modified="2019-05-08" version="1">MYSALRRIASAFPLKKALAYGLNTARRRAVVLRPVHRQFNTFLTSRSLRLNRRTASSLAALRRIHIRAISYTSIPRFVLRAFRVPIAAGAVGAGGFTYANYRFEEFRKKSEDWISSVQDTASDIIDSASEAVKSVSSRVSDVKLPTFTAPQFLKAFISSLEHRGQRSDGDHDGGSSSGSGRGQPDGDEAAALAMMMAAATLSPSDSTAIDGNGLTADARQNGLMHLTRKLIEIRTMLLSIDQSDALKLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGNNMVTRRPIELTLINTPAVNGKEPEEYGEFPGLGLGKISDFSNIQRTLTDLNLAVPASDAVSNEPIDLRIYSSRVPDLTLIDLPGYIQIASLDQPDSLKEKIAGLCEKYIREPNIILAVCAADVDLANSPALRASRKVDPLGLRTIGVVTKMDLVPPDQGASVLSGNRYPLHLGYVGVVCKPSAKQRRADSTALVVHRTESEYFHMHREQFGSSSSLMVGTDTLRRRLMEVLESSMASSLHGITNAVQLELEEAQYQFKVQYNDRRITAESYVAETIDALKARFKGFTTQFRRPHVRARLKAMLDEKVLNVLEQLYWSDKRAAELSALAVDARVRPEDVEPYWRYKLDAASSLLTKSGVGRDATLLVADGLRALIDSIAAGEPFTYHPRAAERLIQFSHQILRDRIGITSDQVENCIKPYKYEVDVDEREWETGRTQAVELFDREMKMCEGKLVEIRKKVGGSRRLSSLVSYVQSLEEKEREKKQRRLTATEEESAGASSETNGDDYRYPPAQILDARTAMLCSDRISILKLRLGALKSKRCKAGPQNDVLCPEIFLNAVADKLAYTSAMFINIELLDHFFYQFPREIDSRLLYDLDRREIVEFARENPVVRRHLDLQERKDKLEEVMKQLNSLATLRPDVQQAPRRQRGLFGGMFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H288</accession>
    <name>A0A401H288_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1303250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619422.1">
        <property type="nucleotide sequence ID" value="XM_027763621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H288"/>
    <dbReference type="GeneID" id="38785426"/>
    <dbReference type="InParanoid" id="A0A401H288"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="433" mass="47122" checksum="E898420D04026E08" modified="2019-05-08" version="1">MISPTLASLLSGRSSPPYSPAIPDLAEFTNPDVPPCPLGWEWCNDMHVWLPADLSPFLDSTRVYRDAAVYPSMRATPRPSRKIARVFSPEFWRKAEKRQQSMPWDEEQRGPIRVERADGWVHVHGVTFSQLDLITVPQAQAMGRAVFPPKYNGSTGHPQHARALVTKTPRSAGKAPRASTPSSEGVMTPTTSTVHPYAPGHLYFLRPPRLGRAAENPLFPSSVGRAARRGREDKPAVKTWLNRRSSREGLITPGNSAAAAVTIHPPSSPSPSLSLSRSCSYRSRRGLTRLAPRLSSPVPDEELNATEARGGKDASGKGQAERGPAHPAPDLTDGDAALVLSHRRPQTLTRPAHRFLGWHRATYTGEAGGTSEGLITPMTSEPPTDSPLFPNAAPQDRPAAWAPDDPARGSRGARGRWVGRREFWIANLGLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2W8</accession>
    <name>A0A401H2W8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1401910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619699.1">
        <property type="nucleotide sequence ID" value="XM_027763898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2W8"/>
    <dbReference type="STRING" id="139825.A0A401H2W8"/>
    <dbReference type="GeneID" id="38785703"/>
    <dbReference type="InParanoid" id="A0A401H2W8"/>
    <dbReference type="OrthoDB" id="3055657at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019173066" description="CHAT domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="42660" checksum="F3BAB5E8F9D29A77" modified="2019-05-08" version="1">MNLRALVFLMNFSLCQLLKISMWALQGCIKVLHMSTQVLVSSVHHIDECAYRLEASTRTIIAAEARDRCQHRYVVGLLGARMQNYHYDHWIATDFVILRTLMDALPDRSSWFCQSSFRDHPPWEILLGHPNADRIVFEPPPFEEIVPDPVALRTRFFHSVINAATVLSRHDELVLVLTGHGTREDGWIWLGVCEDEDNVFLKKEEVELLLDGALCQVILFVTSCYSGHWTSPRWTLHAACQANQVAKSLRKSRSQMFRGGIFVSSLLFAHTAAFSIQAPQPGLVGINGKHDAQSAHNFGPDSHTLPRPIQQTLPTFQALMDHFKARVQSPGTQQNFLIDNVIWDEHSHHNLPLRHLTNDPGSLQRSKCLPPSAITSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2X0</accession>
    <name>A0A401H2X0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sterol 24-C-methyltransferase erg6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1401590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619667.1">
        <property type="nucleotide sequence ID" value="XM_027763866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2X0"/>
    <dbReference type="FunCoup" id="A0A401H2X0">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2X0"/>
    <dbReference type="GeneID" id="38785671"/>
    <dbReference type="InParanoid" id="A0A401H2X0"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000232">
        <property type="entry name" value="Sterol 24-C-methyltransferase erg6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="351" mass="39466" checksum="F63B0BDA97EE15C1" modified="2019-05-08" version="1">MSPVATDSLADGRVGSRIQNYTKFFQEDSSKEAQVDTDNRVMNYADVINGYYDGATGLYEFGWSRSFHFCRFYKGEGFQAGLARHEHYLAAQMSLRPGMRVLDVGCGIGGPAREVARFAGVDIVGINNNAFQVGRAKRFTQKASLSNQVSFVEGDFMKLVEKFGPNSFDAVYAIEATVHAPSWEGVYDQIKQVLKPGGVFGVYEWCMTDAWDPKIPSHRELAHRIEIGNGIPEMRPLAKARQAMLSVGFEIEHEEDLAERPDDVPWYYPLEGDIFKAQTAWDLLTVWRMSWSGKIVTHWGLWFIEQVGIVPKGTWEVGETLKIAGDALVEGGRNKLFTPMYLVICRKPLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2X1</accession>
    <name>A0A401H2X1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1401440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619652.1">
        <property type="nucleotide sequence ID" value="XM_027763851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2X1"/>
    <dbReference type="STRING" id="139825.A0A401H2X1"/>
    <dbReference type="GeneID" id="38785656"/>
    <dbReference type="InParanoid" id="A0A401H2X1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018811119" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="169"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="676" mass="73897" checksum="11607EC9C0284572" modified="2019-05-08" version="1">MGLSGLALTCLAAMPLVGSFTIPSPSSINSDINLLYYNDLDLYTVSEHKSVLLLSPQSRSEAAEACATLGETLLPVNETFFLRELVHSLQYQVYQGAYGEDQLYWVGTSDACQAVNFFGLARAAAYDEELPALCSQSSSFGASPAPSNSLTVNSGNLTITGFRDQLSFRFQGIPYANPPERFTYPMFYSGSPVLNATAFGPECVQSGVPNSSEDCLFLNIWTPFVPLDASTVTKEQLKPILFWIHGGAFTGGTGSDPTFAGGNMASRGDVVVVTMNYRLSTLGFLALEDGTTNGNFGIADQVTALDWVREYIVAFGGNPDRITIFGQSAGAASVRALLASPQAIGKYAAAIPMSNLAGSDYATTYSSYYTIHEVTTVVESILEELGCNVTDALKCLKACNAYDLVNLKNVARFLVIDGTYIIYPELPLNGSRTVANVHTMIGYMRDDGAAFIGYPTNGNLTAGLIAQDLPTTVVNNSLFAPLTGPNTTLDVFNVTARVGTDVEFRCLDQATAWSGLQHNLFESIWLYQFNRSYQPSAYSPNYPVCNAPVNATHPYGDPSQEYFKCHSSELYYVFGTLPTSEPYRDAEDLPFMQTTLDTWTAFARTYDPNPDPLYLAVRGYWTSFGQLAQQAQWLPVTNKTLDTTPLRTLQWPSYMTEFAEQAQCEFLGYPLDYFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H340</accession>
    <name>A0A401H340_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1401850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619693.1">
        <property type="nucleotide sequence ID" value="XM_027763892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H340"/>
    <dbReference type="GeneID" id="38785697"/>
    <dbReference type="InParanoid" id="A0A401H340"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="180" mass="19819" checksum="07BDC9EB9290936C" modified="2019-05-08" version="1">MPTATSAIQVPVQAVLVSLSSFYETHHITKSATFPPHALSLTWQELRETEFFRSNSLDPPCFQPPRGAHLLLSGRPFLPRVVRPLPRSVREEKGGEGARGVREQVVRLAAPEDAVDEETCGAAGDLARYCYSSRRGDARSLEVGVGVVERTRDGKHSVVVTSFDAFAGEVTAQFPYRKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H394</accession>
    <name>A0A401H394_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein sds23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1402810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619786.1">
        <property type="nucleotide sequence ID" value="XM_027763985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H394"/>
    <dbReference type="FunCoup" id="A0A401H394">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H394"/>
    <dbReference type="GeneID" id="38785790"/>
    <dbReference type="InParanoid" id="A0A401H394"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="7">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="477"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="558"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="629"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="74414" checksum="B8B4EEE40EECD5ED" modified="2019-05-08" version="1">MFGAPESYTLLSRQSLPTEKPIEDIVLTPSISRALILCDAQVHFYTLPALDPVGIKPIRNVVTLAVDEQHLRKPPPSPNDLPQTIEPIEFCVIKRNAIALYSLREKLFFQKEIPLPLGGALARRTGHYLCLADSEHYNIIDLEAASLFPVLPVSQAPDSGPVKPSITVISENEFLILSWTGASTLGLFITGEGEAVRGTLEWPSHPEAVCLDYPYITTLLPNNTIEIHSIETQTIMQVISAPPTSPSPGLATDRKTLVASAGGFLIPSTQLSDKLRSTPHPPQTRKSGLEALIYSGKDLIDCPVVGVDSDTSVEDACDLLLSNDLVCLAVNRLPDSPPHSTTYHGLFDFSDVNAFLTLAATRHKLGSEELRGKPNAEEIVAAAKAGRVPVRLVSNLSEKNPLEILPHDATLLSLLGVFSRGAHRVLIQSPPPSNEYLGMVSDRRLLTWFTSYAQNIPSLLRFLANPLSALSLPSLYLYTSVVAVRAADNVLHAMTLMSDLGVSSVAVIEEKTGQLLSAVSVTDIGKIVVPAQSNQILSMALHQFVALIKEPDGSMDGADKFPVYSVTPSSTLFYTMQKLLATDSHRLFVTDDTQSNSAASPSSSTGNLCGLVSTVDVLSQFARIANLPDVDPTRMQRHRRASSVSSQSSSSSPRSGSLTGSRFSPSESLRNSVSSLESFQWAERVPSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3L0</accession>
    <name>A0A401H3L0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1403990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619904.1">
        <property type="nucleotide sequence ID" value="XM_027764103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3L0"/>
    <dbReference type="GeneID" id="38785908"/>
    <dbReference type="InParanoid" id="A0A401H3L0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7370" checksum="501B7A85AFB5026E" modified="2019-05-08" version="1">MIGAVVSVSPVEPDPDIRNVLDRIERSGGARTLGAQRPLLCGRSSYDSAPTFKCSAFACYELHDVFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H449</accession>
    <name>A0A401H449_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1501660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620072.1">
        <property type="nucleotide sequence ID" value="XM_027764271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H449"/>
    <dbReference type="STRING" id="139825.A0A401H449"/>
    <dbReference type="GeneID" id="38786076"/>
    <dbReference type="InParanoid" id="A0A401H449"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="476" mass="52859" checksum="9D526DAAB0681B84" modified="2019-05-08" version="1">MSTSLRYTSPEEIDQIHARLVKTFKSGVIRSLDYRRRQLLQLARMVQDNATALEDALYADLRKPRLESSQAEIGAVLGAVLNAVENLDEWTQPEKPKVAAWRSSWDTTVYKVPKGVVLIIGPWNYPLILTIGPLVGAIAAGCAAVVKAPELVPSVAALLAELFPKYLDPEGYQVVNGAIPETTHVLDLRWDHILFTGSEKTGRIVSYAAAKYVTPITLELGGKSPVVIDPDFDMELAAKRVLYGKLQNSGQLCVSPDYTLVPRAKVDEFIAGLLKAYREFWPNGPFHEGSQWGKIINPAHHARLRNLLEHTKGTIVIGGEYDGEERISPTVITGVEMDDVLMEDEIFGPILPIITVEDLDDAIRILDSQNIPLALYAFTNSEQIKQKLLHSTNSGTLVLNDTYSQLAVYEMPFGGQGNSGHGRWYGKHAFETFTHLRSYINVPPSEEHLMNLRYPPYTEDKYLAMSAPVRLAIPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4C9</accession>
    <name>A0A401H4C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1502180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620123.1">
        <property type="nucleotide sequence ID" value="XM_027764322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4C9"/>
    <dbReference type="GeneID" id="38786127"/>
    <dbReference type="InParanoid" id="A0A401H4C9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="60" mass="6460" checksum="84B38B9D5FD12FE0" modified="2019-05-08" version="1">MLPTTDEDVFFELDLTAVDPALEDVLRGYFLSPVESPVVAIAVDAADDIVISPSEPGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4S6</accession>
    <name>A0A401H4S6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620292.1">
        <property type="nucleotide sequence ID" value="XM_027764491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4S6"/>
    <dbReference type="GeneID" id="38786296"/>
    <dbReference type="InParanoid" id="A0A401H4S6"/>
    <dbReference type="OrthoDB" id="2781200at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="82096" checksum="1459269DB3C6F895" modified="2019-05-08" version="1">MFKKDQRTQLSLLNDDVLLAIISHLATHDALSLSATTRVLHGLATRHALSSVTIHFRDAAHFKIFCRYLLADIPNRLYCVRRLELADPLEKIRPGQLQALVLYQPEFIIGGESRIQVAISALPELIELRLEDFAGVKYIQSLVGFSPVLRKLALELYFRVGISDVLASGWKRLNYVCAELMDLEQWWLTCPVHWLHLRTVESHPDIDFREMRIVLQERIRPAVLSLHVFKGCSNSWAQLIDNLPDTKCLEIVTHHHDKGEMPYAAQINLLQTELSLLLARQNIMCIQIYLDPFMTSPTWFLRPLNPRDRLSSSDIAKLDVTMAATAHRLACSIPSLKYIALGWRQTESDAEMDFARVIRSSWWRVVGSGAGRAVEPISMERGEWQASSAVILPEKDQLIAFCRYILDDAPMQMKYLHGPIVLIWIQLKRRRVRGGYQTPTKLSIPCFVGDIALEELQELQLRDASKRVVDMISRFHGRSHKVLTFYATRDSKIVMALFRLTPLNNWAALRHLSLFRVVVPALVLFPNVKSTRLWHVVIINRDAPPTMAVARAQRLAAVHVTGLGNLWHEVSVGFALGPLQYIRPSVLSLAVPADPSVLFWTRLVEIVPEIRCLDNEVEAIVESAMRLELTALALAHQNIVPSLLARLGLNRIRASITDALRLCHTDARRARWLQHSFAVLRCAAVHSEDEWSDDAFHWSFIKYSGDERYMSEMSSGLYGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H532</accession>
    <name>A0A401H532_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump atB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1602170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620468.1">
        <property type="nucleotide sequence ID" value="XM_027764667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H532"/>
    <dbReference type="STRING" id="139825.A0A401H532"/>
    <dbReference type="GeneID" id="38786472"/>
    <dbReference type="InParanoid" id="A0A401H532"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="88"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="423" mass="46795" checksum="9A20FD8AE81472DE" modified="2019-05-08" version="1">MSSQNPGTFTAVLDVENSASRTLQDKSETSTAIMNTEKTPCDGENGRPPGQSTIGDVKTPPSSEDEYLVNLDAAENPKNLSTARKWVIVIVISTGALCATFASSVAAFTEAGLAKDLHTVHEVTILSISLFVFGLGMGPLLVGPLSELYGRNIIYRISYLLCFAFTWPTAFPPNIEVFLVFRFITGFCSAAFLSVAGGSVSDLFVNAQVASPMAVYTMAPFIGPVIGPIVGGFINQNVDWRWTYRVLLMWQFVEIILLLLLVPETYEPLLLQSKARRVRKETGDDKYYAPLDRRERSILSAMLFSCYTPFKLILFDRMALALDTWNALLLGILYLSFQAFPIIFGSLHGFTYGETGLSFLGIGIGMFAALATQPLWNRFYRKQTIKYNGPPPPETRLVMGQWGAIMAPIGLFWLAFTTYKHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H582</accession>
    <name>A0A401H582_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1601720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620423.1">
        <property type="nucleotide sequence ID" value="XM_027764622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H582"/>
    <dbReference type="GeneID" id="38786427"/>
    <dbReference type="InParanoid" id="A0A401H582"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="804" mass="89054" checksum="CF884FCF7DE1A493" modified="2019-05-08" version="1">MSPHALRPSSPTALGAFNVTARFVNHSQPTPQRGAAESTQRFVGSRIHHHSQLIPQYVVDDSPWLPTASLTRHPPRPTPQYQAPEPLQPPPKPRTKRPRSDMLDQSLSLKYMRPHEKAYLKTPEITPDIFRRFDYFRQNSGGGEHRIHPNIPFPSSHQHEQHVGEQVSDIQCPLPTTSSSSTTTAARGQKRKYADVQLDDGQGGTMLYTAGHIPTTARGSKRARVDNQGPTILTPDIPSSSTRGTKRARIDDPVDDVPPPTILPEIPLSSTRGKERARVDAEVYGVQDSTILPTRISSSSGREKKRARLDLDYSIQVPIVSTADTLSSVARGKKRAHVDDQVYSVQDPITNTSVIPSTSGRRTKRPRIAEQVDITQAQNIPSTDTPGSSSRGRERQHVDPHVERAPCSTTFDAEIPALPATHQQEPKQFDNIQILDTLDVPRTDTPSPFNIDSLFMDMDPDLMDALSHILDTPSFPNYTLSSSITVTRGDERQCAGEHMDNIQGPSAPYTDTPTPSTHTTNKGKRRQYEQVNNVHGPSTLIIDTPTARGPKRQCVDEQEDNARFATTLDNDPLVHFAAPTSRPQKQTGGQSFHDEIPVAGPSTLPPPQQRRRQTTRSQGDEVQTPAASTKPRRTRPPRPKKQQPPQGPVLVRVVPQSGHGAYTLPRSSAVPSQWEQVNSEGCDQGTLAGAPPPPTVDYVEIGFTELKARASAFQNHIQKLQCIKHVLKSRLKGADPKGELAKIERDLELAHHHFEQLKKNGYELQQSCKRLNLSEERMREVRLIFPRVVPVRVASNVEGSSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5X7</accession>
    <name>A0A401H5X7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1700850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620673.1">
        <property type="nucleotide sequence ID" value="XM_027764872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5X7"/>
    <dbReference type="STRING" id="139825.A0A401H5X7"/>
    <dbReference type="GeneID" id="38786677"/>
    <dbReference type="InParanoid" id="A0A401H5X7"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="489" mass="51856" checksum="25B02E1882BA0696" modified="2019-05-08" version="1">MYSRIQIAPVVDQRAFAAADQLYGVEVAEQDYRGVAYPQYATSSAARYAQYAYADDDLDIDLSSRFGKHAEEAFGQFMNDSDNALSSPSGCMPFVHHAAEFAVDGTQVSVDVCGLRAGQYASQQAHVNAASYAGTSTEFAAGHAACVPADPRPYGSQEVGPELSHADAGSPPSPSRYGRDHQPAYVIAGSLAHFKQEPQDDQPIAASWPVYGGGPLAPSFPASPGLAVPGEDQYAADLQYADADYGYDDTAPISPLSDSAYGDSEDLDFGASLPVALHHPSPFRSYTLAAAITPLPEPAPEHEPKRAVSLPAATPQPAASASTPPSAAAPAPRPRGRPRKKPVAQVHAVGYPYPAPLSLDELPLPDREGKPGQALFRLTTTGGPREPPKKKPVMACLFCRERKIACGPPVPGSAELRCNQCARRSLRCEYPKESRRGQHKRGPRAARVQALADAHSSSGSSSNSSSETLPDVFPRAVPMDVEWGPIRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6X6</accession>
    <name>A0A401H6X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1900230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621087.1">
        <property type="nucleotide sequence ID" value="XM_027765286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6X6"/>
    <dbReference type="GeneID" id="38787091"/>
    <dbReference type="InParanoid" id="A0A401H6X6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="183" mass="20037" checksum="20D82F8091568058" modified="2019-05-08" version="1">MTGYYWLDGQEHSLCPAHHTYLATPLRTSEVTVIISDIGCVANTLRGWVEVNNLTHWLTIADWLVERHLHLTTLHECYACEDGLTTIKHTHHCLDALAERWGADVAHAMFDMARTCHHVTRDHIKCDTSTPTMLGWGSNCAPSYTGAAASGVSWARCRGTASWSADAIEVGCSMAQESGGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H7B0</accession>
    <name>A0A401H7B0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1400030</name>
        <name evidence="8" type="ORF">SCP_2000120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000020">
        <property type="protein sequence ID" value="GBE90269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619512.1">
        <property type="nucleotide sequence ID" value="XM_027763711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H7B0"/>
    <dbReference type="STRING" id="139825.A0A401H7B0"/>
    <dbReference type="GeneID" id="38785516"/>
    <dbReference type="InParanoid" id="A0A401H7B0"/>
    <dbReference type="OrthoDB" id="3267813at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE90269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="47133" checksum="6185D76FBEC818BE" modified="2019-05-08" version="1">MLIFLALLPSAYAYSFTFNSVPAQCQDLQIEISGGAGQPPYSVLIIPFGPSPLPNNVEVRTIFEVPFNSSSTSFQLKYPANSEFVAVVSDSSGFGTGGTSVAATVQSSSDSSCFNATQNVSPDFVFSIVPSNQLVQCTPTRIWWDPSTVQGTPQFHGVIPGGQSFAIPEGSLTTVANEGLGFSWTPSVRTGTTLLLLGGDNRGPGTGGSGFYIMSQGDSNTCLNSTSPSSTPGSPAGGSYPTSTNGASTGGGGSGGSHNHTGAIVGGVIGGIAGVVLILAALWFFHRRQQTQQTQKERSVDLLQDHDHDQDQDDGQLPQYYRPEPFLLPEPTIISSAGAFEDGDEATSMSGGARGSMDRRPMRLSQTTMSMSEAGLLRPATPSASATTNTRKTPHPPTLRPVNIIQHDDAGPPPPPGEQHAEEPETIELPPAYTNIRRAQPPPPPEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4R6</accession>
    <name>A0A401G4R6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0100490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608090.1">
        <property type="nucleotide sequence ID" value="XM_027752289.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G4R6">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G4R6"/>
    <dbReference type="GeneID" id="38774094"/>
    <dbReference type="InParanoid" id="A0A401G4R6"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="722"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="894"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1312" mass="147644" checksum="E891888CC071E94B" modified="2019-05-08" version="1">MTSSDAPPHTPQRSDQPPRPLPSMPDDAGNKQIHEPIPAAYFYKNDKPHGSSRTTYVPPTVVSEVPYRSPPPTFYAFNEPQDDEPIPELVSAPDSTSWGNDSWGEQNTWVPTEQVWESSNWGSSNTARKIIIEGRSNDEELRWFDAELRARCERPGPGVLPPVLSDILHDPEHTLYSVSVAQPLPMTMSPQAPTADEVRTAIPHPHAYYCREHNGWVLILWRSSSVLPPLERPLELPDMARRKKTSRCVGGEQPFGQANTTHHWHTYERAVDARKLNPPFHGEDEVLLDLHVCCQCSMYCMSSDVIPGVIPVTLVEELTRDKLAHPTLGRTPKASVLTGWETVLTIIENRLWKGEVRILPVTRPRFQSKIGWNATIKDVFAAVEFLAHTMHDSPTEEIALSPPEIEPSTPEGKHTRAKLLRAWIEVGAWLAVYNKSSKDGLGEYKPLPLHVNVDSSAREEYQTAIGAHVSQIPRGLLHDSLLGVDALDPSWRALGMTPSSYSWELLAFAYLAQCRCDPAHTMFYYTHLSHIVLTMHDSGGGVTTELQSLLLEERERNRYTLQDFIDAGATLGFGKENELGMELDADVDDTFVLEAWRDKRKRAWKEGDRAVEIRRNLNDALHIIADDRASAVLQKAWEEERGSGMSPEAAYSTLEVPRDMDETMLLTVFNMRVEDQPSQGDRMREALTVIAEVTESERLRQFLATGRDPGDSTLSTAPEMPRGLNQLGNTCYLNSLLQYFYTIKDLRDAITPLVNTDVKSLDDSKVTDDDLKRHRVGGRLVTRREILRSKKFVGQLADLFWNLEYCEVPAVTPTIDLAKLALVTSQDEEEDDQDHERTGTDSSNDTDATLVEDAPGPRSTYDRSSNSPPPLTCSDSILGKRPRDTASSMDVDASSLSPQTVDSPVHSPTTVDPRMLTQPYESVASSSKLQPPEQTGDVEMRDETEPFAGPKAPPLPPRKPRPVDDSVMMFGRQHDVSECMDNCIFQIETALLDFQEMANAEEDKTSIVKRLFYGKKRQRLTPLNPSDDTRHKSSIHEKEDLFSHLHINVSGDGFDLYDGLSRYFDDVVELDGQKKRMAVSLVDVPPLLQIQLQRAQFDRETQQAYKSQAYVKFGETIYMDRFLESADPEKKVRAKAIEASLTASRDRLQRLTQDKHAPFAPALGSVADFLAAQDILQLPEVDEDLATRLRNEQSSVTAQIDSERNNAVQLKAQLEDVWKNDTSAAYELTTVFIHRGSSPSWGHYFLYSRHLPDNPDKWFKYNDSDVSIVSKDEVLTDTTSSTANPYMLVFARRDCEAIETVHRFNPETLQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5S7</accession>
    <name>A0A401G5S7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0103840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608422.1">
        <property type="nucleotide sequence ID" value="XM_027752621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5S7"/>
    <dbReference type="STRING" id="139825.A0A401G5S7"/>
    <dbReference type="GeneID" id="38774426"/>
    <dbReference type="InParanoid" id="A0A401G5S7"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="60"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="335"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="493"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="711" mass="79139" checksum="88FE7D74997781DF" modified="2019-05-08" version="1">MASSCMPSRKRGSQLPRLWIDSSLCSYKRSLHTPASTLSSAPFSAAISAATISSCGPSTADAFHVLCLYDFTSDDPDQLSFKKNEILDIIKRENTGWWAAVRPGHNCVGWIPSTFVEAISENKLLGSNGEKRIYDHIRKMYGSPVIPKGGQLLIASPGGETGEQDWVPLPDDEQAPVMQLFSQSAKDCAPFAFSPLIPPHEGIDSTPLNFHDSDSDSSPDNGIMSRLIPNPGSSNHRMLQVPPSRGPPAPNDSASSLHKHLLPSPTSSTARHSRPRPVLIDDCSSLNRLSTLFETKNVEELGSPLIAETLDSFSRAATGQWSDVLKQSHEIQVRHDGMVTAGSLHNLLEKLTDDPAWPPPYMKFHRIFLMTFRTFTTAEESFNFLSKQFHMTAPAGLGPKELEQWEETKLHPLQSRVLSILKIWSEEYGMYQYDRQIVRQVVDLLSSVTAPPLLAVTAQAMIQSVERLMSGVSRAVPGKKNLRKAKIELLRMDPAVVGQHLSMYEHRLYSKIRPQQCIDWGRSRDDVADLITLRATHHKLGAWVKSSILSADSSKKRANMVDFWICVAESCKLLNNVSSASTVVSVLSSDCVPQLHPTWADTSRKARLDILSTFIQSSGRPLAPEQADDVPCVPHIERYLRDIIHTNEQYQDYTVVPVPFINSTVSLINFAKREKWFDIVQAMLCHQSKTFDFPEDATFMEFIAANLETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5T9</accession>
    <name>A0A401G5T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0104030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608441.1">
        <property type="nucleotide sequence ID" value="XM_027752640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5T9"/>
    <dbReference type="FunCoup" id="A0A401G5T9">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5T9"/>
    <dbReference type="GeneID" id="38774445"/>
    <dbReference type="InParanoid" id="A0A401G5T9"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="221" mass="25039" checksum="18E242CE28904AA6" modified="2019-05-08" version="1">MDTSGSSGSGSSGSGTSEFERWRRKFALMTGLGGSQEERLADLEEHHHRTCEKWKRELMNYSPAVVFMLKHLRLSGCPVSSENIVCTPCDYNRAGGFVPELGVIALCQGKFFSRNHMEDTMVHELVHMYDHCKFKVDWTNLRHHACSEIRANSLSGDCKFTRELRRGQLAFSKQHQECVRRRAVLSVSANAACPDVAAAERAVNEVWDSCFNDTRPFDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G614</accession>
    <name>A0A401G614_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0104830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608516.1">
        <property type="nucleotide sequence ID" value="XM_027752715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G614"/>
    <dbReference type="FunCoup" id="A0A401G614">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G614"/>
    <dbReference type="GeneID" id="38774520"/>
    <dbReference type="InParanoid" id="A0A401G614"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="301"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="404"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="520"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="670" mass="73643" checksum="D72937E661193C97" modified="2019-05-08" version="1">MESTTTSSSQSFVPLFDKLPSPSRNLSTASSIWAPQPQPSDTAWSRAIDSFTRVNVINNATRPEARRTTSFPVAFGGEDVFGPVGFVGHRKRDVGAIGDGRKKVSPTSDEIHVEQLLRSLNLNSPAPLIPPSSFPPPSPTSPDLSPISNTSALLTPTDLSPAKMFDPKFAHYDFGGVYSSQPNDRLFETSAPHGYHDGLAGSNLFRNSSSSFPSSRNASAFRAESNAFPVFEPFSEGPSPAPSAAPFLRDSHSIRHRVDSSPVSPAYSQRLRTSSEWVNEERRVVDYTSAILDNDPVLRTVQSSHLQSQGPGPSHAHEPINFLSLLHPSSTPPYHLFVSRIIKSSDQQASIFLQQKLKVADSEERAKIVDAICAKGFEMMAHRFGNWAVQRCLEATASIEERRKIVGCMRGRVVDLATNCYGCHVLQKALDCEEDIRLLIVSELLLGDPAQTLVNKHASHVWSKIMELTWTPPAPPIFTYVNKSLKGKWASLACHETGSLVVQHAFENLEESAKDGIVDELLNQGPDVFGEVAKSQWGSYCVQHILEHGSKSHRDMALDHLLSGLLDYATNEQGVKSVTKALKEGGKETLDKLMKRMCEPSRGGRRAMIVDLALSVTGSQLIASVLPNADKDQRALLYESIRGHIVTLRGCKTGSKVIWLFDRMRAYYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6A3</accession>
    <name>A0A401G6A3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SCP_0105770</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608608.1">
        <property type="nucleotide sequence ID" value="XM_027752807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6A3"/>
    <dbReference type="FunCoup" id="A0A401G6A3">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6A3"/>
    <dbReference type="GeneID" id="38774612"/>
    <dbReference type="InParanoid" id="A0A401G6A3"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="47"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="225"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="489"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="587"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="679"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="756"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1130"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="919"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GBE77695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1229" mass="139406" checksum="B1712941710F31EE" modified="2019-05-08" version="1">MSQATDLEASRSYDETGYGMDEDEEEYEEITQEDCWTVISSFFEQKGLVRQQLDSFDEFVQNTMQELVDENADLILDQADQHTGHDADVTRRYEIQFGQIYLSRPTITEADGSVVPVFPQEARLRNLTYSAPLYIEMKKRVLVGREDPESATGEVIWEQEQEETYDDSRKVWIGKVPIMLRSTYCILHKLKDEDLYDLNECPYDSGGYFIINGSEKVLIAQERMATNHVYVFAKAQPSPISFLAEIRSAVEKGGKTISQFQVKLYHRNQERSLGNVMKASIPYIKVDIPIWVVFRALGVISDRDILEHICYDMQDAQMLEMLKPCIDDGFVIQDREVALDFIGNRGTTTGLNRERRLRYAQEILQKEMLPHISMAEGSESKKAYFFGYMIHRLLLAALERRDLDDRDHFGKKRLDLAGPLLANLFRMLFRKLTKDVYRYLQKCVESHKEFNLNLAVKSNTITNGLKYSLATGNWGDQKKSMASKAGVSQVLNRYTYASTLSHLRRCNTPLGREGKIAKPRQLHNTHWGMVCPAETPEGQACGLVKNLSLMACISVGSLSAPVIEFLEEWGLESLEENAHSATPCTKVFVNGVWMGVHRDPANLVKTIKKLRRKDDISPEVSVVRDIRERELRLYTDAGRVCRPLFIVENQQLLLTKKHIDLLNRSAEEEKALPGSGYKWDNLIKSGVIELLDAEEEETVMICMTPEDLDNSRLQSSGVDPHANDEDFDPAARLKAVTNAHTWTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGIYLTNFLVRMDTMANILYYPQKPLATTRSMEYLRFRELPAGQNAIVAILCYSGYNQEDSVIMNQSSIDRGLFRSMYYRSYMDLEKKSGVQQLEEFEKPTRDTTLRMKHGTYDKLEDDGLIAPGTGVNGEDIIIGKTAPIPPDSEELGQRTRAHTKRDVSTPLKSTESGIIDQVLITTNADGQKFVKIRVRSTRVPQIGDKFASRHGQKGTIGITYRQEDMPFTAEGITPDIIINPHAIPSRMTIGHLVECLLSKVATLIGNEGDATPFTELTVESVSQVLRQKGYQSRGLEVMYHGHTGRKLQAQVYLGPTYYQRLKHMVDDKIHSRARGPVQILTRQPVEGRSRDGGLRFGEMERDCMISHGVAAFLKERLFEASDAYRLHVCDICGLTAIANLKKQTFECRSCKNKTACSQLYIPYAAKLLFQELQSMNIAARLYTVSTGRIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6F9</accession>
    <name>A0A401G6F9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0106300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Possible regulatory or functional link with the histocompatibility cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608661.1">
        <property type="nucleotide sequence ID" value="XM_027752860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6F9"/>
    <dbReference type="STRING" id="139825.A0A401G6F9"/>
    <dbReference type="GeneID" id="38774665"/>
    <dbReference type="InParanoid" id="A0A401G6F9"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF3">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="6">
        <location>
            <begin position="275"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="550" mass="60863" checksum="5D8371FC1B9FD687" modified="2019-05-08" version="1">MSKKEVEMNEEGLFKKWLAQTDDTINQWCNVGQQTQSDDFCEGPAEDSGTSAHGPPEPSMPQAPTSFERNLEVWRQLWRVTEISQILLILLDSRCPTLHYPPSLRAYLSSPPGLASRTRTILVLTKVDISGPAKADAWTRYLNSQYPGVIVVQVESYAEKNSESHHDSTSQRSRRAHEPHLPSAFRQTFVNALRDVHQELLSPPERIRGDPDRLRRWKPPVKRVVDWDNVLKAEGGQVGTVVGGPMIPRSKETEELQRTQGSEEDEGDSEPEFLTIGLLGQPNVGKSSLLNALFGTHKVKASKTPGKTKHFQTLFWTSDVRLVDCPGLVMPNFVPMEVQVLSGIPPISRISAIPLCIYHAAQLLPLEKIYGLTHPSLSASPAEDKRTWRDGMRPQAQSFSKGRETTWTAMDVLTAYALQKGWVTAKAGRPDVNRAGNAILRALAEGKIRWAFWPPGTDVHFMEEHQAEGCGIWMARPVSNAQESELDSDAGGGLSDEESGDECAVYEEEDVSDDETVVSEEEGLASGGWFGALALADEDASDDDSSDREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G740</accession>
    <name>A0A401G740_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0108680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608899.1">
        <property type="nucleotide sequence ID" value="XM_027753098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G740"/>
    <dbReference type="FunCoup" id="A0A401G740">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G740"/>
    <dbReference type="GeneID" id="38774903"/>
    <dbReference type="InParanoid" id="A0A401G740"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="116"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="334" mass="36876" checksum="5B24EFA09DC219A7" modified="2019-05-08" version="1">MLYLTAHPGRPVLIYTAGPLCPISRPIKVQILQPVHPDFVDKLLPEYLAFHNANSLYAPNVHTLPWNPTVRQKPPVAGGSEPLKVGTVEDIALSKCTMRVFTPEGNPPSEGWPVFLFFHGGGWTLGNINTENAFSTNMCKRANCVVVSVDYRLGPEEPYPAAVEDAVEALRWIYEKGKECLRVNVQKFAVGGSSSGANLAAVITHKAALMTPSISLTFQVLVVPVVDNTATSSRDPYPSWKENANTVSLVPDKMIWFRKNYSPNEEDWTKWDNSPIFAPEETFKKCPNAWIGVAELDILRDEGIAYGEKLRKAGAEVETRVYLGSPHPIMAMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7J2</accession>
    <name>A0A401G7J2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0110010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609032.1">
        <property type="nucleotide sequence ID" value="XM_027753231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7J2"/>
    <dbReference type="STRING" id="139825.A0A401G7J2"/>
    <dbReference type="GeneID" id="38775036"/>
    <dbReference type="InParanoid" id="A0A401G7J2"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23452" checksum="029607F405085111" modified="2019-05-08" version="1">MSSLAAILSDPAYHDYLAILKGARNGFVYGVKVRFPHALIMAILFGRGSWKARVQTIFRATKQHALNLAKFVSLYKTLLLIQRKSNHGTQRGVDTFIAGLISGYFVFGDRNAVNEQIVLYVCSRVVASFIPRATTPYAMASTASSAVKPIPPDARKFSIFAALCWGTVMWLFAERGETIQPGMFHSMNYLYRDSEHWSNLWTLLWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7R1</accession>
    <name>A0A401G7R1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="10" type="ORF">SCP_0110890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7R1"/>
    <dbReference type="STRING" id="139825.A0A401G7R1"/>
    <dbReference type="InParanoid" id="A0A401G7R1"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="949" mass="103173" checksum="02566ABD753CF303" modified="2019-05-08" version="1">MSLSELTRNSFQSGIQPAKWINLCKLFTSKRQLQLTSEAVQMDLGNSVLLLFRSYPGDPALQAYLNCAIQDQILSLPIFVVMFLSAAKSQELHNTATLDILCRVILDAHYASGSPPIGSVVSYAESSVEVLGTVQDAMTLLKTAYSLPTTPLHQLTTSASELLILLLSCVTDVSQISTAQAMMYFAEASEMLQVLRLSSGVKRVLESFALSLSLLLGDDAKVAREAQMMHTLLALSKGDRQGPGSDTDTITCSLVLHSLILSRSSEYGSGDPSHVAAILLGLLRWSSWTPVVFYTQLLLSALTCLAQNLSLGSSSRSGLIWRAFVVGRLPFLMSLFQQAAELDGTAGVDWRTVLQLALLSVLQHTELLDKCDSNSRPGSADSGERSAHSRLFVLEFFYQLLAVGLIDSSFATTVSPTLPNEFHPKLQSEAQDAGLDLASYFEAKLSVEVGVEDAVFLERTWKDPTSHAALAETVHKRFTSPASLDIESLSHLCRILSANEPALDILSLHIKIPQLVTHALAYVDDYDFETIGDPQAAVSHLGDVLLFLQSTIVRFNLLSAPFVLGGRALSPEFLFSAATIYRLADLKGEDLGAFNGWFKALFDINSEGIEDTILRATRPKTLLRISATLFCHAIGLCSERKMDKDVLNSGISYFLGPLLNWTLLGIVKALLAEIHRRRFMAPIHLEVLQTVLNSQSCPPVVRHLSAPAVLRLFPSGTKLGLTPTIVYDPSPIRRVALQALGLPVDDTQDALSLNTHGPSWADQPRHAVRDALSAARAGKAPSLDVTRCLVFTTPTKFLNALWDELMTAATIGDVEAPTRVATFVLTMPRCPRSPPLLPIFLHVVLPTIVASADHLASSGRAPPDQTITIELLVSVISSALTAALHLEWALVTVCGEKRFVLGQSVSYMARRLAGDLRRKGHGETSAAIMQRLVESQPFMANFPTFSADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8N8</accession>
    <name>A0A401G8N8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0114110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609435.1">
        <property type="nucleotide sequence ID" value="XM_027753634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8N8"/>
    <dbReference type="FunCoup" id="A0A401G8N8">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8N8"/>
    <dbReference type="GeneID" id="38775439"/>
    <dbReference type="InParanoid" id="A0A401G8N8"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="56" mass="6534" checksum="B0E886F4837FCE3E" modified="2019-05-08" version="1">MTHDSVWFSRPRKYGKGSRQCRLCAHQAGLIRKYGLDLCRQCFREKSAAIGFNKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8U3</accession>
    <name>A0A401G8U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MutS protein homolog 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0114850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609509.1">
        <property type="nucleotide sequence ID" value="XM_027753708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8U3"/>
    <dbReference type="STRING" id="139825.A0A401G8U3"/>
    <dbReference type="GeneID" id="38775513"/>
    <dbReference type="InParanoid" id="A0A401G8U3"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="851" mass="94071" checksum="ABA8BF6D55B12477" modified="2019-05-08" version="1">MTHTWTAQSRPTTARPQTAASSRHESSYIVALVEGRGVAREVGMAALDKDTGRVTLIQLADCPTYVKTLHQLHLHSPSLILVPDTFLSVTDVLLASGAKKPSTTSILIQCIMEEFDSVPIEPVPRKYWNETAGYDFLNQLTVEDDEGAATLVAASSKYYALSAASALFKHAEFKLNLRFSASSLLIRYVQVEGTMMIDPESARNLELVGNISYKKSSHSLFGLLNHTYTAMGARLLRVNVLAPITVHGSIEARLDIVEELVQSEDRFNEVKNALKTLNRMDFDKLISSLASSEARDTGTAKPAAARVAQMLNLRNIVKSLPLLAKALTGCRSELLHIIREMISDERLERIEQLVRNSLNEEATPAKGGLGAVNARVYAVKANYNRLLDVARETYKENVGDIFTLQQALSDRHSLPLSLVYQDTGFVFALRKGDLEGELPKGFVNVTMQKGRWTFSSVELKKRNARMKDALDETLILSDKIIQELTAEIVVDIGALYKASEAVAILDMLWSFAHVSILRNYGKSKVWYFEHVSHTFAAVRPEFTGTLAIKAGRHPILENVQSAGTLVPNDVYCCEASSFQIVQGPNMSGIETHPCIHELLIDPDAGKSTYLRQIGLLTVMAMCGCFISAEYGSFRLHDALLTRLSNDDDMEKSLSTFANEMASSAMILGIATPNSLILIDEVGRGTSPREGVGISHAIAESLIQLKSYVFFATHFNELVTTLSRQPSVVNLHLSVQKTRQSSSNFGMAFQYKIVDGAPESQEHYGLELARLADLPTDVLGEAQRVAETLTELEARERQESETSKVAVRRKALLRLRTQLAQALDHSSLPDEELAAYLERFQKEITKALHDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8W0</accession>
    <name>A0A401G8W0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein AIM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0114810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609505.1">
        <property type="nucleotide sequence ID" value="XM_027753704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8W0"/>
    <dbReference type="STRING" id="139825.A0A401G8W0"/>
    <dbReference type="GeneID" id="38775509"/>
    <dbReference type="InParanoid" id="A0A401G8W0"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="249" mass="27093" checksum="CF8AA5CA6C94418B" modified="2019-05-08" version="1">MSLCADCFRGVRHEGEPEGKIEQIGGVECYVATPSVDYPRDKVILFLSDVFGIPLLNNRLLVDDFARNGFKTIMPDLFNGEAVDVAAFSDPNLDRRSWKAKHSPVSAAAIVENVVKVLTESGVTRIGTTSYCFGAQAAFYLARANISHVTVLSHPSALDVPADLESYHANSKAPLLINSCEVDTQFGPDCQAIADKIFGEGKFAPGYQRTYWEGCAHGFAVRGDLSDPKVKAGKEGSFKATIEFFAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9S1</accession>
    <name>A0A401G9S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative pinoresinol-lariciresinol reductase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0201120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609828.1">
        <property type="nucleotide sequence ID" value="XM_027754027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9S1"/>
    <dbReference type="GeneID" id="38775832"/>
    <dbReference type="InParanoid" id="A0A401G9S1"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="36358" checksum="65AE53E1FA276BF2" modified="2019-05-08" version="1">MSYLTSTRLSRAQYVVAIAGATGTLGREVTAVFLGSYRPFFSRVIALVRDPSSSGAQALAAKGAELHQLSESDPLPSLVKALEGVDVVVNALPPGPENVQDALVKASVERGVKVYFPSEYGVDHRKDYWGYKHPAWLGKREHDRRARARGQGKLKVIEVYIGLFLELCLTPFLGFDHANNLYTFYGSPNQRVSWTSKGDIGRALAELSLVALSPELSTRVPDYVRLSGETINITDIRESVQRVRKELGHDRGEIVLKSEDLENFKKSTQEAFPHDPKASLAPYLRLAMAEGELDLSVDNNNDLVNPDQSVWKWKTVEDFARENNAWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAL9</accession>
    <name>A0A401GAL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0204020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610118.1">
        <property type="nucleotide sequence ID" value="XM_027754317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAL9"/>
    <dbReference type="GeneID" id="38776122"/>
    <dbReference type="InParanoid" id="A0A401GAL9"/>
    <dbReference type="OrthoDB" id="3147730at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17636" checksum="00E125417EC20099" modified="2019-05-08" version="1">MDQMIPYDAICFPSDDRPPHLVSLMTTVLNAVLPNPPQPYRCGRMPHPEIHIDYIAEGLGPRSWQYHLVEALDGMNKKFTTPYILFYPIVSRDGMPFPVNKCIREIQGACFNEAKAWRGNIVVAKYRDADYSQMAEASMADFPILKNYLKTCPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAW1</accession>
    <name>A0A401GAW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear GTPase SLIP-GC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0204790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610194.1">
        <property type="nucleotide sequence ID" value="XM_027754393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAW1"/>
    <dbReference type="STRING" id="139825.A0A401GAW1"/>
    <dbReference type="GeneID" id="38776198"/>
    <dbReference type="InParanoid" id="A0A401GAW1"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="153"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="3">
        <location>
            <begin position="953"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1200" mass="132787" checksum="1CD94B01D5D33B44" modified="2019-05-08" version="1">MPFIKPEPQEQHALPLADSSAWQSNAGIDTRATTLVKPETRDSNQILSDACSTSPPLNSAPALPNVKPESAVPQNGGQGTVANPEPPRAFYKVYASPDDIQYVPEDALKEGLGMVERIKGNIKKLELGSKLRKDVWLREIESLQSQGAPTTMIAVCGATGAGKSSVLNAILDDNIVPTSGMRACTSVVTEIGYHTKRTIDANVSFLSETEWREELVVLQHDMVDEDGKVKRSTDMRTEAGVAWSKVHAVYPSIIPEQFVKMTIDQIISSDIKIKNILGTTKHITAKDPKTFGREIAKYIDSKDQKRGDKEKKSKEKKDTDKGKEKSLMDKIRAASGATHSTKYKDDLDGPALWPLIRGVGVRCQSPALSTGALLVDLPGVADSNAARNNIAKDYMKKCDCVWILAPITRAVDDKTARDLMGDAFKMQLMMGEWLHVPISRKVSLTYCAPLESLRRKFLSYDANAITFVASKCDDISCSEVIRALNLEDDPELVDIEEQISQCKDDTTEWKGKKADAEAAAKGIDTQLKEVRAYLAEYQEHLKALEEGRTFVPVLTAKSGKRETTSETPKKRKNTGGEKKGTSKKRKTSGDGEDGEDDLIVVDDADEDEEEDIMDVEDELVFSDSDSDKQSDDGKDDDDSSDNSDSESAEDSEEEQEDDDNEAEEVTVESLQAKIGEAKDAIKAGRLQLSEFRKQRKEASDMLATIKKKQLKAQREKNAFCSLKRSEFSRDVLKEDFRTGLKELDDAAAEQRDPDSFDPTVNLRNYDEIDLPVFTCSARDYVRLKGQVKGDGDSTCFSKVEDTGIPELQKWCHQLTVSSRERAARNFLTHLRTFANSVRTYVQGIGDVTVSDREAMREKWESIAADDSSALDHDDPAYGFLMDDELDMAFRGMYSLNEQATKVDRQGNAAGVAPRLTKDFETVVKSCVEELKACFREGLEEKCAAGAINAANVAIDTSDTFATSMHWATYRATLRRDGAWRRDLNVELSNPLTRNIASSWSKVFESDLFASFEKATLDAINKLLAEVEESAAIGLKERARGQAELCLEDARVALQKTLDVVRDTMNTQQKEASRSFAPEVQTQLREGYRDAMEERGIGSVARQKAVFRNFLASVRDHVFTDAASVLLKSLVGAADAVGEALNKSLAELAQKIEVSIAVLWEGPRDDPSQMKVRAQVVATMTEIMEQVQMWVDAGRNKTVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB20</accession>
    <name>A0A401GB20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="9">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0205450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610260.1">
        <property type="nucleotide sequence ID" value="XM_027754459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB20"/>
    <dbReference type="FunCoup" id="A0A401GB20">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB20"/>
    <dbReference type="GeneID" id="38776264"/>
    <dbReference type="InParanoid" id="A0A401GB20"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2150:FF:000001">
        <property type="entry name" value="Ribosomal RNA-processing protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="440" mass="48467" checksum="9F5627B0C99C3181" modified="2019-05-08" version="1">MALFEVPGWSVPSTLVSDGPHSARKRKRVPAQDGDRVSGAVVNFEKLMKKLAAGSGTGKEAERPRGNAKRKNKIPKRDTGRGDKEKEKKARRETGRPQDACTQVQRGESMGMDKGRANRKKKGEAVRAEPSDGRDGVPPTKEEKKKLAQSVPLDVHDEEGPSRKKRKWKDKQKNQDDAASHDAPRSSSTGRPTQTSKAEQGLTALQAGMKSSLDGARFRWINELLYKSDSEHAHQMMRENPKAYEEYHTGFRHQVHAWPTNPVAHYIAVLGSYSLKTVIADLGCGDAALARALTPKGLTVLSFDLVSDGTFVVEADTCARVPLPGSDTEGEGEGSVVDVVVCALSLMGTNWLGCVREAWRILKAGGELKIAEVASRFTDVDEFTSVVSSIGFRLKSKDDSNTHFTLFEFKKVARKAKGEKEWEKLLARGSVLKPCEYKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBJ4</accession>
    <name>A0A401GBJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0207030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610416.1">
        <property type="nucleotide sequence ID" value="XM_027754615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBJ4"/>
    <dbReference type="GeneID" id="38776420"/>
    <dbReference type="InParanoid" id="A0A401GBJ4"/>
    <dbReference type="OrthoDB" id="2802569at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18913" checksum="65EFD746189A2CC0" modified="2019-05-08" version="1">MPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRPVHRPYYSASAKDPNAMDVDRVNISCLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMQEDLAQKKETLKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBY9</accession>
    <name>A0A401GBY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0208980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610611.1">
        <property type="nucleotide sequence ID" value="XM_027754810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBY9"/>
    <dbReference type="STRING" id="139825.A0A401GBY9"/>
    <dbReference type="GeneID" id="38776615"/>
    <dbReference type="InParanoid" id="A0A401GBY9"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="15561" checksum="3CF59CD8EC5C5E3A" modified="2019-05-08" version="1">MDYKPRFYQPFSLEEAVRMDVSVLTEEISRLQNSIEHLKTTQEELKEAMSSTPDPEFTKAVEENEVVIGSQEERISILRVALTEKGVLSSSHYNPVVTTGHAVNGHTSQQTGPDHTNNTAQAAASLSSQTDPHSDDGGGIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCE9</accession>
    <name>A0A401GCE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0210450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610757.1">
        <property type="nucleotide sequence ID" value="XM_027754956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCE9"/>
    <dbReference type="GeneID" id="38776761"/>
    <dbReference type="InParanoid" id="A0A401GCE9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="12089" checksum="4366CAAEF1BE1842" modified="2019-05-08" version="1">MITPARLATQRYRSLWISFHLTMNMPDFLRFSIILRPCTHSAIIERACKTTLFLTYFRRCAIPDPSKGAGSVKLHTVGSEPHTMGSTNVTLIPFKTVSEEAETFILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCN6</accession>
    <name>A0A401GCN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein pim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0211500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610861.1">
        <property type="nucleotide sequence ID" value="XM_027755060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCN6"/>
    <dbReference type="FunCoup" id="A0A401GCN6">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCN6"/>
    <dbReference type="GeneID" id="38776865"/>
    <dbReference type="InParanoid" id="A0A401GCN6"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="133"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="135"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="198"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="267"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="329"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="386"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="449"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="512"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="569" mass="60427" checksum="3FF24E1941724DDE" modified="2019-05-08" version="1">MSLRRSTRSSSIKPKPAEKSTTKPATRASSKPLPKATAKAAPKPATKTSGRKAATKRPASPENAPPPTKRARTAPKAVENGVPHVNGKAEVPPLRSRSRTRKTSVPPAKKVVPQAKPYFNPLPNPPEHLRPAPLLWAWGAGNFGQFGMGSDFLGDFEKPKKNALVEERIHEGVFGSPEAGLEAIAAGGLHSLFVDEKGTVWSCGVNDDAALGRITAEVPNPEKEGEFLDVDVLTAEPHPLQSLVEEKFRAVRVAAGDTISAAISSEGDLRVWGSFRGVEGILGFSSGHRHQFLPAAISELPLKSKPGDVEKFAAVVAGNNHLLVLTTHGNLFTWGAGEQGQLGRKVLERRKIHGTVPEKIVLGARSHKAVVIGAGSYTSFAVDEHGDVWAWGLNNRGQTGTGFRSAEADGDVQLPKKVLGLSKAELGSDIVVTQIVGGEHHTLFLTSDGKVYSCGRSDAGQLGLADDDKAFQDRVHPDMLAEPVLVTFPDLEDPVVQISVGIHNNAAVTRGGALYTWGTGVQGELGLGEDVEVRTPRVVVRKEGGSWAALAVSCGGQHTLALFKKKTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD31</accession>
    <name>A0A401GD31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0212250</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610936.1">
        <property type="nucleotide sequence ID" value="XM_027755135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD31"/>
    <dbReference type="FunCoup" id="A0A401GD31">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GD31"/>
    <dbReference type="GeneID" id="38776940"/>
    <dbReference type="InParanoid" id="A0A401GD31"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="15">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="16">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE80023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="447" mass="49470" checksum="9BD326A2E851C655" modified="2019-05-08" version="1">MREVISVHVGQAGVQIGNACWELYTVEHGLSPDGRLVEGSPSAHDDSFSTFFSETASGKHVPRSLYVDLEPNVIDEVRSGTYRSLFHPETLVTGKEDAASNYARGHYTIGKEHIDTVMDKIRRLADNCNGLQGFFVFHSFGGGTGSGLGALVLERLSTDYGKKSKLEFSVYPAPTMANSVVEPYNSVLTTHTTLEHSDCSFMVDNEAIYDICKTRLNITSPSFWNLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPFPRIHFPLATFAPIISAEKAHHEQNSVADMTFSCFEPGNQMVKCDPREGKYMACALLYRGDVVPKDTNAAVSIIKTKRTIQFVDWCPTGFKLGICNEPPAHIPGGDLAKVTRSLCMLSNTTAISTAWSRLDHKFDLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGIDTADVEEVGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD52</accession>
    <name>A0A401GD52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0213170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611027.1">
        <property type="nucleotide sequence ID" value="XM_027755226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD52"/>
    <dbReference type="FunCoup" id="A0A401GD52">
        <property type="interactions" value="617"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GD52"/>
    <dbReference type="GeneID" id="38777031"/>
    <dbReference type="InParanoid" id="A0A401GD52"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="244"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="863"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121519" checksum="A243695EF0F286AE" modified="2019-05-08" version="1">MSSADAAARTETQTVSPVPPQQVHALLPAHSGENVLNTNQPSTTTVNGRVNSAEKLAEGQGGETTGAGPSCEVTGAVHVGAADHLEGAEQTGDDSGQWSDDESHDLKRVKVYQLIANRWVDQGTAFCFGDFQDNEALLVARAEADFNHIILSTVIRSSDVYQLQQDTLIVWTEPDGNDYALSFQDPDGCAEVWQFIQEVQRHMNSGEDPVLSSSPLMGHDQSITTASIIRSGHLPQPQLGIIGEIEKAIKALSRTNALKERICEYIQTEDYIRAMIDVMHQAEDLENLENLHALCSCMQAILMLNDHSLYEHILEDDLFFGVVGMLEYDPEFPTHKANYRDFLRQTSQFHQPIPLGDETIQKKIHHTYRLQFLKDVVLARAIDDSTFNVLNSCIIFNQIDIINYVQNDPSFLPEVVATFMDDELLAAVGLPAKSREPEKEKNSQMDSEKMDVDQPEAKTNGAVNPIGIAEGAPSSAPPSSDDEFKRRCEVVLLIQQLCAMGKNVQLPARMTLFRALVERGIVFAVQWGLDQSETEENGRQMIAASGEILTALLDHDVGGVRTHVMKQLTRMEHEKASGKKIVAKETVLELMCRILVRSRDLAVQSQVGEALKLLLETQQDSLEQHAPPGTKTLQRPKDEPNTERFLDFFYKHCIGTLFRPLDDIPVFSELTEPVLVLSRERANLYFYLCDLLSTFILQHSFRSHFYILSSDISLRVASLLSARDKHLRLAAFRVFRTCLKLNNPGLFNQLISKHLFKPILDLTLRESHRDNLLSASCQEFFEHMRKENLKDLIAHCMTVYGPRVRELAESPMGGPRFKAFIRRWEMNVEPPPEEEKPEKLPLNGPRRWGEGRLLEAEEEDYFNADDDDDEIVPVVSTPPRGNALKRKRMRGMGPSVRSIRPFTPLPRTPPLARLVDYDEGDNLGGPVEDSPMQSSPSISKTASTSSGYFPLSSPSVDGPPSSRMIRRSLVKPSSFPDEQDDLLESLFTRSGSSSGLTGPPELGAKRRREDEDDELLERLASRSKRTSVGPGPSPEKENADSPVAGKAGLAKPIEESPKKMKVKIGSLGAALASSSPSTSVPPAPSRAGTKDGDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE65</accession>
    <name>A0A401GE65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0301840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611382.1">
        <property type="nucleotide sequence ID" value="XM_027755581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE65"/>
    <dbReference type="FunCoup" id="A0A401GE65">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GE65"/>
    <dbReference type="GeneID" id="38777386"/>
    <dbReference type="InParanoid" id="A0A401GE65"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35613" checksum="B90ECC92609D9074" modified="2019-05-08" version="1">MAPFDLDACIQQLLRKQLLHEALLREICEKTKEVLMRESNVVHVSAPVTVVGDIHGQFYDLIEIFRIGGYAPETNYLFLGDYVDRGLFSVETISLLTCLKLRWPDRVQLIRGNHESRAVTQTYGFYTECVRKYGSSHVWTYFTDMFDFLTLSVVIDDKIFCVHGGLSPSIHSIDQIKVVDRFREIPHEGPMADLVWSDPDPEKEDFAISPRGAGYTFGSGVVYKFLETNNMSHILRAHQLCMEGYASLFDKHLSTVWSAPNYCYRCGNSASILEVGPGGSSMYFNVFQAAPENERDGPSHQAAQNAGGRLPEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEM0</accession>
    <name>A0A401GEM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0303490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611545.1">
        <property type="nucleotide sequence ID" value="XM_027755744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEM0"/>
    <dbReference type="STRING" id="139825.A0A401GEM0"/>
    <dbReference type="GeneID" id="38777549"/>
    <dbReference type="InParanoid" id="A0A401GEM0"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE80632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="159" mass="17878" checksum="3CA963F3B03E60BA" modified="2019-05-08" version="1">MASSDSADIIAIIDNVQSLSGKSCHEDTALLEPYTYIQSRPGKGIWERMIQAFDHWLKVPKPQLEIITRIVDLLHTGSLMIDDIEDNSQIRRGGPVAHKVFGIPKTLNAANLAYFMAYRELSSLKEIYSTSGCHDYPYLYKADRRPLSVILDDIVTGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEM3</accession>
    <name>A0A401GEM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monothiol glutaredoxin-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0303320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611530.1">
        <property type="nucleotide sequence ID" value="XM_027755729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEM3"/>
    <dbReference type="STRING" id="139825.A0A401GEM3"/>
    <dbReference type="GeneID" id="38777534"/>
    <dbReference type="InParanoid" id="A0A401GEM3"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019364091" evidence="1">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="93"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="186" mass="20708" checksum="76643D6EC08C7C3F" modified="2019-05-08" version="1">MSSPYRRRRIVWAAILLTGAFLFYLALAKSKDAAESVPEIHALLHFVTEHPDQRLNGSALDPAEKVDVRVFAPGGDMDWEKHLRVLRDEAPLVVFSKTFCPFSQRAKALLGSYLISPPPTVIELNLREDGPVIQGLLHRLTGRRTVPNILLMGESIGGADDIQQLHDENKLKVLLEERGLVVNGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEY8</accession>
    <name>A0A401GEY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0304200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611614.1">
        <property type="nucleotide sequence ID" value="XM_027755813.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEY8"/>
    <dbReference type="GeneID" id="38777618"/>
    <dbReference type="InParanoid" id="A0A401GEY8"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="PPR" evidence="7">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="7">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="9">
        <location>
            <begin position="305"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="7">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="7">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="7">
        <location>
            <begin position="480"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1303"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="693"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE80701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1375" mass="152655" checksum="BBC5498EEB4A5A94" modified="2019-05-08" version="1">MLASSSRNALKTAHTRLSGIATDLCSAQQAQVVTFGWSRCAQQQRHESSAQVRTQQNIFHERDGRARRHGGLRNQPYQFTPDVDFRGTTVMTEVARYNLKLSRFIEGSLTRVVMRVCLQMKNKGLRPNLTTYTYIMQACGIEGSYDMARATLEDMVSMDIRPDREIFHYLLNAARYQDSRKLWEVISMMERFDIRPNESTYEYIILQYAESGNLELALQYLSALGMRGLSPTLKTAQGIIRVAGSMGFPRLALDLAEAFEQTSVRRLDGEVWAECLESSSEALYEEGVLRTWQKVVHELNITPDEGCCIQVLHTAARHGLSGLGLDVLRVLSRIGVAWQEYHFAPVIEAFCKDNKIKDAMEMLAMIRAHGINPISETAYPIFQMIQKDPDTVDEAWGYLETLREEGKVVDVTALNVIIQASVGIGDLQRAVGTYKAAGDLGVAPNVDSYNLLLSGCIVSQHRELGDRLLGEMKDASIKPDVRTYERLIVLCLTQANYEDAFFYLEEMKNEGHLPPVTVYEAIIRKCVQVGDTRYQLAVDEMVECGYEMSEKLEKLIQSGGENEGSEGTPDPVARKILMMGRRPAKTEMRSQVLPHLAAQPPPVSSSLNTLLFLVLPCMNTRNHDVIDVDAAEDANEVQFRGFYRNVGAHHTYLVNRIRENNVIDLISDDEGDGGAGPSIAPQKGFRPKSLVVAKDLPRSHPSSSRSKLPSDEKAMALAKKRPLSSEKTKSSEKGRQPSNDKAKPPAKRDSSSSDKSKKRNLDPGERIEPPAKRFKGSDGKFAPAPNPYSRKRPRQPLMASSREAEVIVIDDSDEEELPLKRARTSPDDTPDAPDPVPELEDELGRSTEVLQCLALGQDGPDPDPDPDSEYDYFHDAYDLHRKSNWEPFPESTVDYELETKEGQTLAEKMAKLSVSTYSTTRTLFSSPWDSDNEDGTDVWCRLQGMHRPRFKCSSRSPYDHLVPAKSLSTTSGSVMKVRQSAGIIAIASAVADGTADMDDQEPSAYNREGNLRVWCDGTEFTLYGHERSYTSEGRDMRRFYTVNDVQFDPALPTRLVSCGHDLTVKVWDCTAVESGATALEYATTPEYGAPELVQTVTFPCIPESMQFKPEGSVLAVAGSNGRVYLQRNTNLKYRTVLTVASGAEGGVVDLTWGAESSANKLFATAAGEGDGVHKAFDVTKGKEICQFDAEDPGERLAIDESGTTLALATLSPTRAHHLHLYDARRCLRRATQTVALERFRGGFNEVNRMSFSPDALFLAVARSDNAVSVYDARMLSRGPLQAFAHDERSTKKPARYGVVEALWVERGRALLTGGNDGFVRMWDVRRAASDPYNGVAVAGCDYDIAHFALGKDRGDKPLVVGDLSGRVKVFDYGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFD0</accession>
    <name>A0A401GFD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0306250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611817.1">
        <property type="nucleotide sequence ID" value="XM_027756016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFD0"/>
    <dbReference type="STRING" id="139825.A0A401GFD0"/>
    <dbReference type="GeneID" id="38777821"/>
    <dbReference type="InParanoid" id="A0A401GFD0"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="52"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE80904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="345" mass="38505" checksum="E93A02A3699E55FA" modified="2019-05-08" version="1">MSTDEQVQVQDTPPNVNEDTQMQDASEPPTGPAAMAPKNKKRPRIDLAVESRERKRGKTMFGLVLGTLNKAKNEDKERNASEAAKKRHLIEQRLQDKLRKETDSVRRAEEAKKDKTTANRKEEELQLKDSIHKLRRTRLPLLANFLLTSDQIPVDDDTPPPPSTNPLAPMPRTHPPPLYYLPAILTPAQETFIQRRQAEVKEATEKEWVAFREERTAGVEEITQLRQRVAEEDARKKLERGVEPEAGERPGAPTAAADKDAVMATEDSTGGDVSSSTANRPETQDAPRPEREAGMEVDKDEAVPATAAPSAVETAKEVVQVQVQQQEHKEEPAPMHADDDDAVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG41</accession>
    <name>A0A401GG41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0308580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612045.1">
        <property type="nucleotide sequence ID" value="XM_027756244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG41"/>
    <dbReference type="STRING" id="139825.A0A401GG41"/>
    <dbReference type="GeneID" id="38778049"/>
    <dbReference type="InParanoid" id="A0A401GG41"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="310" mass="33903" checksum="77AC15807C1ACE8E" modified="2019-05-08" version="1">MEVHPAALCPSSSLPSLHHSPSHSPDMPHLHPSYSLSRDCNHPPGSDPDSPRAPPNASPSSSRSQSRYPMGTSSDYPVSAGWPLHANSLPTPHPHASRPIPASSRHSLRPTSPDTPRRASTDPYLYHSVQLPSTQPTASPTRAPASHQPYSATAVPRLPPILQVEKQQVTTSATQAASASRRRNEAHFVCPVPGCGSTFTRRFNLRGHLRSHTAERPFLCEWPGCNKGFARQHDCRRHQALHASRSQGHLCQGCGKNFSRLDALNRHWRSDGGAECRQTSEAAASAARLSPEDEWENRSNSTERSGRRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH30</accession>
    <name>A0A401GH30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0311600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612344.1">
        <property type="nucleotide sequence ID" value="XM_027756543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH30"/>
    <dbReference type="GeneID" id="38778348"/>
    <dbReference type="InParanoid" id="A0A401GH30"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019315241" evidence="1">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="9571" checksum="9CA6B6D338C54309" modified="2019-05-08" version="1">MRFSTISALIVLALAYGAVQAAPSAECRSESSIEPAVSKAPKPNISYHDYDAIIRVCSAENCGGTYDPIALSGLHNTCYYPAINFESIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHB8</accession>
    <name>A0A401GHB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0312220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612406.1">
        <property type="nucleotide sequence ID" value="XM_027756605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHB8"/>
    <dbReference type="FunCoup" id="A0A401GHB8">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHB8"/>
    <dbReference type="GeneID" id="38778410"/>
    <dbReference type="InParanoid" id="A0A401GHB8"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="245"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="817"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="879" mass="96702" checksum="8F2FE15ADCDBE9F3" modified="2019-05-08" version="1">MDRSPVPFPSLLHQAEESQNMDSRPAIPSRVHSSPSLPNLWLPAHNGPLPHHLAPRHQVRYRPHLRPLDLASSPTSSPTKLRGPYATPVKAEPSRSPSRVPSMLTPPLTPSSSFNSNTHEAPSTPPEATSPLRWIHHAVDSFSDTTLIADADYSPTSLKGNRSLPRAGYLTPSSGRTHSISSDGEPSYSPGLSGQSDAADLASALAAGISDLDLTPRDERKLALSQEHPLDAVNDLRVTETTPSRFLMVKNVPPSTSFATLRMAFSSMGDIKGIFVRFQVSHSVILLAFFDVREATRAKSQISGQTLPGLEDVCLEAGFVTGEQLDILTGRSPFVTEMDGAIYVTVEDCVVDAASLRNVLASFGELISFEAVGADPHDQTYLVEYYDVRTTASVFKQLNNRTILNARLRLSRKDTDRYQSADDSLLAAGSSHQPAMFSLNGTAQQETERSLQGRVRPRSVSASETMGAPDAVYRSWKGRESPTEHGRRPSNDLFFDAIGKTSALLETPSRPRSISIGTDNMVRSTRPALGYNASTPAYHYSEHPYSQGHSSASAPLYAAPSYAYSQSMYAPEVRMYGTMDADVAASSHWAFAAPPAPTIEYYLPPSPRVAAYQPYPSTPRKAVHSDHQRQYQQQGYPGQTDFGGISAYGTTSDVHAFHSYTASALDFSERDTQGQLGAAMQQGNDKNQLNIAAIEEGKDMRTTVMVKNIPNKMSDKDLMAFINKVCPRRIDFLYLRMDFQNGCNVGYAFVNFISVGDLLHFAKTQLGVKWNMYSSEKVLQMCYATYQGKEAAVEKFKNSCIMDERESWRPKIFYSDGPNQGLPEPFPPPTHLRRKERSSHNRGALFVPGAHHVQGQGPHRDGGSTLYHYRAPPPRMSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHC8</accession>
    <name>A0A401GHC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612481.1">
        <property type="nucleotide sequence ID" value="XM_027756680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHC8"/>
    <dbReference type="GeneID" id="38778485"/>
    <dbReference type="InParanoid" id="A0A401GHC8"/>
    <dbReference type="OrthoDB" id="2991206at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="448" mass="48575" checksum="BA35DE3340B66A95" modified="2019-05-08" version="1">MPRRQAVQGPSQTFTFWGMVGVVMAALKLKEHMDDYRRVPSEEEGLGPLALHSPVLDANNIGASGDGFLDTEIPGARPKRSKRNCCVCCGMRCGLFWKAFGIVCLLFLGWQAIKLAIWAVTPKPTGLEGMPEFSTSLGCSNAPYIYNVTDTTFLVPVGLNNADHEIEILGKAVGTLTFVQGDSDATDVKYDITLRADQDGLFDSILLQHSTAYEIEHGISNSHTRLATTYESSACMRYDIKVSVPPTLKNLAVSTRTVTHIKFDTDSMFDFDKLSVSMRAMMETGHLLLPHTGVHAGMLLFDISRGWLVGDVAIVDKTTLSTSKGDAVMNVHVHPVPSTADRPATAELQTTTGTGRTDVFFVSSAGHVHRPISSTHSSLRGGEMYLTYKEAEFKGEVDLSAKSYSASGLQGSMMRHGGMGGELPWVGDKNGGDKIVAQSPNGWIGLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHP4</accession>
    <name>A0A401GHP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0400120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612554.1">
        <property type="nucleotide sequence ID" value="XM_027756753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHP4"/>
    <dbReference type="STRING" id="139825.A0A401GHP4"/>
    <dbReference type="GeneID" id="38778558"/>
    <dbReference type="InParanoid" id="A0A401GHP4"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="304" mass="33748" checksum="6C157600B227039F" modified="2019-05-08" version="1">MLPPRGYIFIGLNVVRILSIVSLLLVFASSIFVIVIDVEAVNRFMALPADQVPDCDYVPGSDVPNQPAGIFWAILNRLLIIFEVIVLIMSEIGWPAAFFERFFPVLGRSFGLGSIGTFQCLLGAAILSHHVDDFTLVAAFFLFALGCVNILAGLIFREKAKWKRSITEWRNERKGVLPRTLELAPKFTRPSSTFVSNLFGKTGRTTETTEDPEKRGYGFGRQGEKAAAHNGYVISRPLESMSRYAPAPRNQHPPSHHSVQSDDARSEASEDESSHYPNTPQTTYDAPHYPVLTKSIFKSSNTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIG4</accession>
    <name>A0A401GIG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0403380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612875.1">
        <property type="nucleotide sequence ID" value="XM_027757074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIG4"/>
    <dbReference type="STRING" id="139825.A0A401GIG4"/>
    <dbReference type="GeneID" id="38778879"/>
    <dbReference type="InParanoid" id="A0A401GIG4"/>
    <dbReference type="OrthoDB" id="3227225at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21777" checksum="858E360E95935D57" modified="2019-05-08" version="1">MSSTSTHTPNFAKLNDSNYPTWSGEMAAWLRSANLWRLVNGKLPQPKLSGSPTAAEQTKLDTWEANAEKAAGQIYLMVEPDQRTHFAGVVDDPIKMWEQLAAVHLQKKPGARFNAYDDVFSIRKQPEESLQGLVNKVNAAMQHVKDLRPNDFDLTKLDEELTSMTMIRALPVEEYGAFTSTLLQRDILSKDVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIK0</accession>
    <name>A0A401GIK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0404060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612943.1">
        <property type="nucleotide sequence ID" value="XM_027757142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIK0"/>
    <dbReference type="STRING" id="139825.A0A401GIK0"/>
    <dbReference type="GeneID" id="38778947"/>
    <dbReference type="InParanoid" id="A0A401GIK0"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="816"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="855"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1267" mass="136757" checksum="1ADDFBA162469D1A" modified="2019-05-08" version="1">MGIIVSFLFPRHSMDTQLSVSSQASSSSRSSSPKPDYPPSPLSERAPSPPTDRSVPPEKHQVLASPPLESLPYSSHAIGIGILSPQLIIGPLAPITRASLSPLQHKSSPSQQCSNPFDSQTSHPANCSSSALSTAPADDPQSTQSFPASFSGSAGASGLRISIPPPNPTISTFTPSPPLRIPPAIDPLPTSPSAPLDLVRPLHVGVDLALSPADITSPSVDPVLDFTEFDADGLSALEKIYLFSRSPSGFHRVFIAHALPRYLGSDAASDAQYPSREEAEQISPGEAVEYVLPLLNGLAMDDDEAVKEALAAELVPIIWWFITHCRLVEDDFIPPSVSFSPLASPVEPITPPAIPLPAVDHPPPAAEVESVPPTHPTFISVQAFTPILGMLLLSQNGFVGGPARYAVVELLKRVRHADEREYEGSAYVAAATAKLRNAKLGPGLLLNVRAAAEQEIPDALDVGLLGYAERRLFEREIVHQVVIGMGRLDMPDDSASISIDGGESESSAMDLDSPSATYSPTTAVPTPLAGAQQQQDSYFPLFETVSSPIPVANSFFPESSPGEFPVRNQDNFTPPTPMSEVPSLSPLSSTSASTPLSASSVSSSSLDSPASHPRADLPSWDESEQYMSPRPRVEEINVESRTVEKRRPPSPRPALAFPAILPAPHIPAEGINIADDIELRDNVHMEDEWQTPAQQEGGDDIQMQDITGEYGASGEHEDAEGHDSLSEEAAVGRLSSMSLVAAVTASAVDTDDNTLSNFHPRSFYPTGAMGHEMCDAFVAEVERVGRDPVYWVRREATFAVGALAKVVPDEVVVSSLLPLFESLCQDATWHVRHSVLFALPAILSRLGLDERRALALDVMLPLARDESPTVRSAVLEALGEVMHTFTDDLEGPPRALLDLFLGVRDETLAIEQPLPSGRPPGPLASDVSESGSSWSEFSVGVGSDTDIYDDPARPLVCAFNYPAVALTLGRARWPELRELYRTLARDASFKVRRTLAASLGELANIIGWEHARDDLMQVWAASVSAAESEVRLKAVENVDVFLCAIGESERREVVRTLELEFRAGRMKGWREREELAKKLEAFVVIEGLEKATLRRLLMAALEDNVAAVREAAVDVIPAFMKTWRPHPEVLAELCSDIGALALSESFRKRTTYIRCQQVLIVSNQGDVVITDDAFWEALSALVHDPVVDVRIHVARLLGSVSERYYDNPLVLERISAYAQHLEHDTSHDVRAFAHSVLAHTVALPVAGPPEATKSAFMFSRPPPPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIU5</accession>
    <name>A0A401GIU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0405040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613037.1">
        <property type="nucleotide sequence ID" value="XM_027757236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIU5"/>
    <dbReference type="GeneID" id="38779041"/>
    <dbReference type="InParanoid" id="A0A401GIU5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019528077" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="7974" checksum="7231564031722924" modified="2019-05-08" version="1">MQAANTYLHLCSLLVVFWAASSTVSAVSVPVGSDGLFPRGRLLNSPGNGVIDDNQSAGLPMAWQRHPKRFYDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ51</accession>
    <name>A0A401GJ51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0405690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613102.1">
        <property type="nucleotide sequence ID" value="XM_027757301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ51"/>
    <dbReference type="FunCoup" id="A0A401GJ51">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ51"/>
    <dbReference type="GeneID" id="38779106"/>
    <dbReference type="InParanoid" id="A0A401GJ51"/>
    <dbReference type="OrthoDB" id="65596at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="10">
        <location>
            <begin position="128"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE82189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="332" mass="36152" checksum="D2F611D72DD8098B" modified="2019-05-08" version="1">MAPVRLRHPKGVTTIQVDLDASNVLGLQQAIFSATEIPPSRQDLRAGYPPHPLTLVPELPLESLGLKPGEQLIVTEKAAPTRAPSQASAPARVPEAMTGLTASQVREIPVSQTDSSMPDTVPVEGGYLVHRIVPDDNSCLFSSVALVFEQSIDKAPLVRQIVADAIRKDLETWNEAILGRPREEYISTILKPTSWGGAIELTILASHYSTEISSVDVETGRIDHFTPPSNHDSRNRCILIYSGIHYDAVSIAPMLDVPDDFHQTIMPVGDAGDNDPVLLAAKKLADKLRAKRAYTNTATFDLRCQICQKGLKGEKEARAHASETGHVQFGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJH1</accession>
    <name>A0A401GJH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0406830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613212.1">
        <property type="nucleotide sequence ID" value="XM_027757411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJH1"/>
    <dbReference type="STRING" id="139825.A0A401GJH1"/>
    <dbReference type="GeneID" id="38779216"/>
    <dbReference type="InParanoid" id="A0A401GJH1"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="411" mass="47020" checksum="8E4ECA2333A264AD" modified="2019-05-08" version="1">MRSSVHLPALQLGENQSLKKADEWRRLLTITPVLLWVCWKDEHDRIPNIEPTIPPNAKTRPTHSRNCKALYFAILLLCAGVCMLVSRKISMSQARIGQDFLTQYNRTLQQLGIDLTINNHLSTHFAKFIKLYGPVYGWWLFPFERFNGMFEKVNTNGHDGGRMELTLMRYWVRCHLIYEYLLALPANAYTKEREYIEAVIKSEGCSERGGMMTELAIYRSEATTDRVKLPRVLGKHINLRIFLGPGTGGIYCLALDYCQRLYPDLHLIDNLSLDHGTAFVATRVARMLTYIHRYAFIVDKNTNEHCPVEIAALLGIKVAEKALHVCVVIRRMVSDEDIPPFPWCTYSDLLGIHVSYANRFHGYEIVPAVALDAPLALIPIHSERMGQELWASISFDHTGNELEVMDDDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJN6</accession>
    <name>A0A401GJN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0407570</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613286.1">
        <property type="nucleotide sequence ID" value="XM_027757485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJN6"/>
    <dbReference type="STRING" id="139825.A0A401GJN6"/>
    <dbReference type="GeneID" id="38779290"/>
    <dbReference type="InParanoid" id="A0A401GJN6"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="130"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="391"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE82373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="457" mass="52268" checksum="8059857887980279" modified="2019-05-08" version="1">MEHSVFPSFRSTSLPAPIPQSIASPFDLTHPRRESGHIVNHGPITPPMSPARSEEGNGTIFVDPEPRYSSEGRPCSSDVLPHSHPRRGGPEEAMDVDPTLSPDSPRPPLRHLEDEQSHLEKKGTLKLTDFEVRGTLGTGTFSRVLLVRLRNAAASPSSLNAFALKVLRKSEIVRLRQVEHVNAERYILSRVRHPFIVDCYATFQDSLNIYMLLSYVPGGELFTHLRRARRFTPDVTRFYLATIILALKYLHTFNIIYRDLKPENLLLDSRGYLRLTDFGFAKIVDDRTWTLCGTPEYLAPEIIQSDGHGKAADWWACGILCYEMLVGYPPFFDESPYGIYEKILKGKIYWPREMDRLSRDLIKAFLHPDRTKRLGNLIGGPQDVLEHPWFRGVDWDALERREIRAPIIPQVAAVDDTRHFSHLPLPPAEEIPGLIKEELPPPLHRRFDPTEYQFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJN8</accession>
    <name>A0A401GJN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0407590</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613288.1">
        <property type="nucleotide sequence ID" value="XM_027757487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJN8"/>
    <dbReference type="FunCoup" id="A0A401GJN8">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJN8"/>
    <dbReference type="GeneID" id="38779292"/>
    <dbReference type="InParanoid" id="A0A401GJN8"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE82375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="385" mass="43358" checksum="1393C8082E15676B" modified="2019-05-08" version="1">MAARLNGGWLRGTTIRKGGVSTNPTSRTNTPQIQSTSTTVFGGGVKDASGRVSEYFSMDDQCPVCKSDRYLNPKLRLLVGACYHKMCESCIDRLFTLGPAPCPICGKVLRKLAFTPQTFEDLGVEKEVAVRRRIAKEFNKRREDFPDVRSYNDYLEEVEDIAFNLINDIDIPQTEARIAAYRIENAALIELNVQREEQYIQQLKQQEEAERLEREQHALELRRAEEEEREEREKGREDIIDKLETSDKDATKLIARSRAEALRRASARSSSTTSALQSSSGLLRSRATQSTAVPDLPHVPLEDDWYAYEDKFAMRDNYDDPTSEAVRRDKEGIMRAGGYIVEEAWQRALRFAVAGLEIAPLQGLHPSDPPSPALPQDADVVMASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKA8</accession>
    <name>A0A401GKA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0409880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613516.1">
        <property type="nucleotide sequence ID" value="XM_027757715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKA8"/>
    <dbReference type="STRING" id="139825.A0A401GKA8"/>
    <dbReference type="GeneID" id="38779520"/>
    <dbReference type="InParanoid" id="A0A401GKA8"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF21">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="437" mass="48334" checksum="D9F8AE67E4DC4EA9" modified="2019-05-08" version="1">MTTVTKASLSIIQATKFKTITRQRLRKYSWLPDVLRVKGSVVPRIVGPVLTVTVFASIVAWASARGADISLTNSVVPLLAVVVGLILVFRNGTSYDRYYEGRKDFGTMTSHIRNLSRLIWVNVAVPPADDISKGKSPSANLTAIELRRRKVDALKLCVCFAFTVKHYLRGEDGLDWEDYAGILPASTARLGQNGLNSRKTSAFVSYSATARTSRSNSRVGSTDEVDSERSSVVSPDATKRVRVKRSKDKLKQPGVQGSRTPLMSTLHQTIDFNANPEQLSTPLPLVIAHELWRMIFLFKRDGYLETVGPAGTNALNVHVQGMVDMMTAMERVANTPIPRSYSIHLKQCVTLYLFVLPFTLIKDLGWGMVPIVTVVAFTLMGIEGIADEIEMPFGLDKSDLPLERYCDDLKEEIEYIVERLPDGGEGMYGIDDGLGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKL0</accession>
    <name>A0A401GKL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613618.1">
        <property type="nucleotide sequence ID" value="XM_027757817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKL0"/>
    <dbReference type="GeneID" id="38779622"/>
    <dbReference type="InParanoid" id="A0A401GKL0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="309" mass="34267" checksum="C09276F3FC81723F" modified="2019-05-08" version="1">MGSNYSTLRSGSPSILGKRSTLDDALDAPPAKRLMSECCGFVEDAQVLSKRRHEEDDSQRHKKLKEDDSNSQTDKRVVVHATHRPVNSKHVFPFLMLPVELGNIILHILANDRDTLYTLSLVSGLLRVYVLPLYLKAAGFIDSSNNVGPVITYEHTRPIIMWRGMQGLPTPPSMWIRIIANAAMAKCQLYGLARFFISSRTQLAISNIVIKLHNARLALATCKFLQTVAASGVSHLCLKSHLSSDLRAIESPEDIPVVNSGLFYPRLQKMQVKSAVFFSAEYISWTVHTLNSAALTALDLQLDNRGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLF9</accession>
    <name>A0A401GLF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613921.1">
        <property type="nucleotide sequence ID" value="XM_027758120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLF9"/>
    <dbReference type="STRING" id="139825.A0A401GLF9"/>
    <dbReference type="GeneID" id="38779925"/>
    <dbReference type="InParanoid" id="A0A401GLF9"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019575302" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27463" checksum="A54EA50727A00FD8" modified="2019-05-08" version="1">MLTLPVLWAFSTLILLVSSSPVISAYGASQVFLSHGHREYENGELPPVGNTEGWIDPRINGGRFLDFTTDVLGEPLNIVISGLSDPFILTEVGLHSYAKSIGFSEECLGLHYGQIHEADLGDGGGRKAQHFLARQDYFPFIGTCWESVRGGQHFRAWHQNDTAANSGAWFIGASLEKDSSRNHKIVPDGYNLGRDFIVEQATAGTRWKGMWWKAEVEWRTGLLEKGKRGVNHGIEQDGRVAILTVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLX5</accession>
    <name>A0A401GLX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0502600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614126.1">
        <property type="nucleotide sequence ID" value="XM_027758325.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GLX5">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLX5"/>
    <dbReference type="GeneID" id="38780130"/>
    <dbReference type="InParanoid" id="A0A401GLX5"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1249"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1292"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1492"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1293"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1306"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1492"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1506"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1518"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1584" mass="179812" checksum="384013E2FA668F4D" modified="2019-05-08" version="1">MASVAQPPQKLGDLVQHLVEQHRTDIHVDSDTQHPQTPPIPNASHFTRSSGDSHHGWRLPAEQRTPPPNTPSGRTGPPRSITGNYSFAASNIVGSESRDDSAQRRGKSLLSLAQIRSGEASDFTTATTSFRGALEYADPVQRERERELAEKKARRRDSVFQDSLNFRRWISDSPKEDSPPISLENASTHANDEDIAQQTPQQDSGTSRIQVSRTLSTHIQDEARRSAAPKWGRLRSLLPHITGHYKGAEKAPSTVVPYSVNITDELITGGLSTLMLRLWFERDEKDHRRVPIMFHRLRIRVSDSLHPLHGHKAVFRIECEYANGAVRWVVYRQLREFLSLHTHYALSNAYNRNVETLPEFPLTSLPYFKFLKEGGRDVGRADFARLQREALENYLIGLIRAVMFHPASNRLAGFLEISALSISLAQSGGAQYKAGLLRIDAVGSKGGFGRKGTPWRERKAQKWCSLAVWDVFLIDSEFKIERPTRYYRQGLNLFHQFEDDHEEEVQDDGRNKQVVQNDARSGHLSLGVSSLRSRISRVFHVGHRGHRRSDSHQTTSAHAAKESAGHQMGSASSRSSNLSAAYPSDRPLTPMLDPSTNTNPLLAPDDEAEHGYDATGDQKDQKKQSQKDVSKHTFYIENSQMKLKLFARNERQMLQWMAGLEKVARESHYTGKNRFDSFAPIRLNVAAQWLVDGRDYFWNLSRAILLAKESIYIHDWWLSPELQLRRPNKPRYRLDHLLERKAKAGVKIYIILYQEVSNRTTPTDSKRVFFLFRLKIIADGTNPTATPNKDLQLYIRTSSCSAHHPIYRQEHSTGHIWDTPQHVLVDDPDPVSGGSEHIWTGKDYSNPRIQDFHSLNKPDEDMYDRTKVPRMPWHDVSMQLVGQPARDLCRHFVQRWNHLLRIKNHSRIMPFLLPPPEFRPGELQQLGLTGTCELQICRSAGPWSLGTPDRIEHSIQNAYLKAIQMSEHFVYIENQFFITSTVVNEVKIENRIGDALVHRIIRAHRECTPWKCCILIPLLPGFSFPVDHSDASAIRIIMECQNRTICRGPNSIFGRLRKEGIDPDEYIAVFSLRNWAKMRGDVLTTEEVYIHGKVCIVDDRLAIIGSANINERSQRGDRDSEIAAVVRDTDMIDCTMAGKPFKVGRFAHTLRVRLMREHIGVDVDAMYEDDLMACEPVKPPYEQQEWDPDVEQEYGKESGVTHLGKGERRTAVRNLLHDTIDELEQTIHGTGDTEPKDIAATLQKTSVNSKGLDNTAGERSLREEPQMFSRDGGRVLGFPSAIVPTVEEKIEVGSSQSQFQNGDGHQLTDRGHQDYPPEARLQNGELYGAPAAPDTQRDTEQQQAQEVKGDADEEEQKALGARATLRRHQAARLGSKPWSLPTSAPRVDPHGFEDPICDTFWKNVWLACAVHNTEIYRKVFHAVPDDLVTTWKLYKEFVIHHERLNKPVKEHHTAEPLARLPSETADEEMLGQPHTVENTVHAEDAVSNRVRKEGCDQTDHHLSSSPHPPTPPPPVGAAEKEARERKTTKGTEPFDQTDQEEMEQLLGELRGHLVLYPTRFLEGEDAANNFIFNADRLLPLPIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMQ6</accession>
    <name>A0A401GMQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0505490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614411.1">
        <property type="nucleotide sequence ID" value="XM_027758610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMQ6"/>
    <dbReference type="GeneID" id="38780415"/>
    <dbReference type="InParanoid" id="A0A401GMQ6"/>
    <dbReference type="OrthoDB" id="3269456at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="271" mass="30222" checksum="6E80755F63DC50B2" modified="2019-05-08" version="1">MAKVFQDTRCVKLFDEWTTRTKAPNLEMGADGQGSQFLLETYDQFETVERQFDVQVSSGGYLYLVWRSSREEVTLCSFRLPRRNPNLALQTVVVAGEGPAFRADLNMVIDPYGALAELVAGGRLSWTSDNVVSCMELKGEYDDRWSTPVQSSFDMVHAGELVELSVNFRLREHVSPNGANVGRKFLTRLDTVMIVSRLGMKLIVDCESEHLSMMRIAAAADNTGGGKAPKKRRFSYLQSVPSVLTSTEQHLNSLTVLDKTDDVDQVMKPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNL5</accession>
    <name>A0A401GNL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PITH domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0508880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614744.1">
        <property type="nucleotide sequence ID" value="XM_027758943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNL5"/>
    <dbReference type="GeneID" id="38780748"/>
    <dbReference type="InParanoid" id="A0A401GNL5"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="211" mass="23209" checksum="FFC136313D8CFEB6" modified="2019-05-08" version="1">MADATGNSHNSISSELAGSDLSNLYGSIDRINVHGLNLTVPEDAQAVIKPWDEREDTSKSAESGVDDQVIIHVPFTQNVRVKSVLLKLGRGEETPRRLRIYANHTNIVDFNEAEEVTPQLNINLLEGEVAVTEYPMRSAVFANIHSLSLFFCDSVGGNSLRIFYIGFRGDSRNQRKDATQKLEIPAANAADASLVDRVSERSRGSQQPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNN5</accession>
    <name>A0A401GNN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2OGFeDO JBP1/TET oxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0508690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614725.1">
        <property type="nucleotide sequence ID" value="XM_027758924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNN5"/>
    <dbReference type="GeneID" id="38780729"/>
    <dbReference type="InParanoid" id="A0A401GNN5"/>
    <dbReference type="OrthoDB" id="3200752at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="6">
        <location>
            <begin position="236"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="441" mass="48920" checksum="B11F4CBC91D50EC9" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQLPEPAIHLIKMSNLSPMPLTDQIAGVLELMFRRKLHLATHAAHSAPSIEVPPSMPSALLLKCNGIADALVKAILNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELEWKWPPPFGESEIRIDQPATLVDMHGCILAWILPRVLIPDRQTKMLQATRALHPAIAASKPSSITATGSLCLSPGWFQQVREHMESGRLETSASLKLEGGRSWLHDIHDSSALLGAILAVVHPTLYATGRQCLGLIQQDPELREMVLNWSLPFNALQVIANRETPFHRDSKTRYTFYDLLAMLGNYTCAWLKFPAMRVAIDYSPGTVIAFCGKAIRHGITRADGERLVYAYFMREGVQNRLGIPAPHWMQASYYASHIGMCTVHHRRDIMPKTDGDENTMQGMETVDGSFVGGTNLAEVMAKCMESRISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP48</accession>
    <name>A0A401GP48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0509990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614853.1">
        <property type="nucleotide sequence ID" value="XM_027759052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP48"/>
    <dbReference type="GeneID" id="38780857"/>
    <dbReference type="InParanoid" id="A0A401GP48"/>
    <dbReference type="OrthoDB" id="2796963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30984" checksum="54689FAC5FC3ED0B" modified="2019-05-08" version="1">MSATPTSSTDSAEASNTSTAHGFQALSPATSLPFTFVIVFVAVFLFFVGCSCGSRRFAWELRHRIAVQDQDTPRRVRQSRPVLWDVWTQMGRNTRKNWVGQKQIEEAVLDIWSAVQPLSVTYVREHQRPKHRNADADCARPPVSAALPVPRPPAPLTLPSAFLRVFERILFLPPFIPPRIPPRRDETEFPEVPKAPPPVRALQVSILIAMPSPVRGTRRIPRSMDDLPEQKEDRIVDEERRGRTTDEVTNGDAADGEKLGEYVIGMTEVPWTDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPJ0</accession>
    <name>A0A401GPJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615025.1">
        <property type="nucleotide sequence ID" value="XM_027759224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPJ0"/>
    <dbReference type="GeneID" id="38781029"/>
    <dbReference type="InParanoid" id="A0A401GPJ0"/>
    <dbReference type="OrthoDB" id="2803071at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47197" checksum="F8AC7E485B741044" modified="2019-05-08" version="1">MDPTLLALLPRSSTVGLPYDDFFRGEYPKDMDAYDTFMDRLAADYRVGRRYILSDLPYSVTIIERWPMLDFPWMNTESLSLVHRTVPEMLQSESFKFSHASAVITIALTRPIQTGSPNCSQVWQANLNVACPVDSVLPGCANAPDAPVIIKIFQESMFNEPEFFNERGIDSGTWRTGFQFAKAEAEAYWNMQSLQGKDVPWSYGFFKVKLPNGEEAFAHVMEFVEGLPGYGIFLRDLGVDEKLEVADAMASGLHSILQCGIIQRDVKSHNMIVQLGAAQPVVFVDFAGMVPLRDIDNGRISWEVDNEMALLIRALREMGVTMQEIADWLQDRKSRRVPWTNLFAFFDNRSPGWFDYFDGLSDELIGLNVNSGEEDETEQSESEESEDDASIQCGESDGDNKIEHEHEHDHEDIDNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPJ9</accession>
    <name>A0A401GPJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0601250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615060.1">
        <property type="nucleotide sequence ID" value="XM_027759259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPJ9"/>
    <dbReference type="FunCoup" id="A0A401GPJ9">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GPJ9"/>
    <dbReference type="GeneID" id="38781064"/>
    <dbReference type="InParanoid" id="A0A401GPJ9"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="474"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="621" mass="69135" checksum="5D213604C7D9A961" modified="2019-05-08" version="1">MDIESLSVTQKEALSQLQALMDGGDQDVAIGVLQSAGWDVQRAAEIIFDHGTPAPAPVSRPPVEEFEIDDSEQGLLIPNGRGREFRPIPTSSSVTLARPLRAILSVLVFPLRILTSIIRFIFRVLHIPLPQFAPFTFSNLTFTYRQLPGMNRDGKAMDSKSVVERWVRALEEETGAVCVSRSGTTHKNVGTPVTNGHGLSSGTAAGVAGPSSLTSRPPRGVDGEADGETKLLPDFFLGSYEQFVRSCERDVRIGCVVLVSEEHDDVAEFKRSTLTDPTLVQAIQENDILVWGGDIRDREAWSASQKLQATTYPFVAFIALQARRGTASSTSPVPTLTILSRHQGPAIPSTSAPTAAQSLVTHLNEHLLPRVTPFLARVRTQAAEREHERALRAEQDRAFEETRRRDKERVERRLEEEKRSQVEQRLREEAEQRERAERERAEERRRAYQARRMEWRRYARKALVLREPRPGETGRGKTLRVGLRMPDGRRAVRFFGEGDPLTALYAYVDSLFIPLEFAQDKDPFTAPAGVLPGEAGLVEEVESSRKSKDEWWGFKLVLAYPRKEIVWEPAKRLGDVEALKGGGQVVVEMVSDVGVVNGKGKRVQNAENGVDSDGYATEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPM1</accession>
    <name>A0A401GPM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0507600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614617.1">
        <property type="nucleotide sequence ID" value="XM_027758816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPM1"/>
    <dbReference type="GeneID" id="38780621"/>
    <dbReference type="InParanoid" id="A0A401GPM1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="173" mass="19478" checksum="252A9955F485B231" modified="2019-05-08" version="1">MAVFCSGCKRQFTHTRGLSRHQSKCSLYRKHVEEQIKIHQDIHKRLRIQAAQREKEISRQTQIPSTQTEEQDSGLEAEFGGSSMPEDVPKAETMQQPLTEAARPLSFHADERGVEGDECGASVEGDERESVEDDGEDSESEDSEDYDGDEEDVEDIQEDLWEDSDGLEGFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPV4</accession>
    <name>A0A401GPV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615145.1">
        <property type="nucleotide sequence ID" value="XM_027759344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPV4"/>
    <dbReference type="GeneID" id="38781149"/>
    <dbReference type="InParanoid" id="A0A401GPV4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="70" mass="8421" checksum="B2794055C3CEBFBB" modified="2019-05-08" version="1">MEALKRLEEAGQKCERARVEFNNLDYNIIYKGYQKKEIAKVRTLYRTTYSWYEGVAEEVRLIEEELSIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ62</accession>
    <name>A0A401GQ62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0509510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614807.1">
        <property type="nucleotide sequence ID" value="XM_027759006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ62"/>
    <dbReference type="STRING" id="139825.A0A401GQ62"/>
    <dbReference type="GeneID" id="38780811"/>
    <dbReference type="InParanoid" id="A0A401GQ62"/>
    <dbReference type="OrthoDB" id="2802397at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="393" mass="43295" checksum="3EB64A3151847A3F" modified="2019-05-08" version="1">MSTPTAAQVAAQFEELLMILNGSFISSCCELSICAVILYEHLVTFGTEYDLVWGRKLTGPNVIFFINRYALFVWSIVNILGLFSWESARRYNFFWQCAEAFVMQLMVYTIWAVFSGLRVYAVSSRNWYFTVPTVALGMVPVAANIYSLAKTSYAFVVVLPVLGHICQNTSYLTSDFAILTIASDVIVLCVTWFNTYTIKRDADNANIKATIVTLLLRDGTFYFLCLLCLNIIAIVLDARTPYVYILYFVAPISSMLISRFLLNLRHIYYATGSSAGSGDPSGPSTGTFMSDMQFAGAASPYIGNMGAPLSHGTFMLSGGSVSESIDDDKVVVPLELAQADSAGTVGTLSNDLENTDVYKAVWQVSKDPLRVGIIPPRDEMELGRLADKGDRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ96</accession>
    <name>A0A401GQ96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614837.1">
        <property type="nucleotide sequence ID" value="XM_027759036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ96"/>
    <dbReference type="STRING" id="139825.A0A401GQ96"/>
    <dbReference type="GeneID" id="38780841"/>
    <dbReference type="InParanoid" id="A0A401GQ96"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="95" mass="10518" checksum="FC19D8434B4EBD18" modified="2019-05-08" version="1">MSDLATARAYSTDSAGMHLSHMLPLKLRAIAEAGFTQTELGLPDIQAYAEQLFPGYQNSDNRGRRDIEKLCEAATKIGAQCEKLCSFLVRQVREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQF5</accession>
    <name>A0A401GQF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0604500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615384.1">
        <property type="nucleotide sequence ID" value="XM_027759583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQF5"/>
    <dbReference type="FunCoup" id="A0A401GQF5">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQF5"/>
    <dbReference type="GeneID" id="38781388"/>
    <dbReference type="InParanoid" id="A0A401GQF5"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="666" mass="72957" checksum="98D96987F3617ECA" modified="2019-05-08" version="1">MPKKAQRPKKQPSRVSNIRLDSPPLIGPPPTKRQKVKPLSSLAKPPVFGLTGSQPGLSSQSDPKKKGKERETPRLSEHEKLDDLMWVDKYEPTTEADLAVHKRKVQEIRQWLLDAFDGGPSGKLKKYRRILALTGPAGTAKTTTIRVLSRELGFEILEWRNTMDERFSRDDDFAEDMEYEGLSDKFRTFLERASSCNSIFPSTTTKPSSSRPSQAATGPRRQIILLEDLPNIAHASTQAAFHAALEAFAGVPEPGVAPLVLIVSDAGLRGEDGEDVGGAWRARGREALDIRSVLPPALLNSSCVTQIGFNPIAPTLLKRALQHLLDTHFAAAAVGAPPAKNLLNAVVESANGDIRSAIMALQFACVAEAAAPGRGGKRSRKAGGPSARVLLEAVTRREQSLALFHLLGKLLYNKRKGDPPNASAAARDIQRDKEIDARLKDPPSLPSHLKEHERRASRVDIEMLYADTPIDASLLSLYVHQNYTQYCNELDQCDAEADWLSWLDASGGEAWYQANPHHFHLLALGTLHALPSPVARRGQKAYKPAFFEVLHRERAAEDSVRDVQAWLRRHEEWRAGGWSRLNVALELGGVLGAREHAGGAAPPPGSHRLFSKMEFAREAGPLVQVDEEGDVPQDMLGDENIGFTEGAGEGEAHGGGWLEGDDIEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQR5</accession>
    <name>A0A401GQR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0605310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615465.1">
        <property type="nucleotide sequence ID" value="XM_027759664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQR5"/>
    <dbReference type="GeneID" id="38781469"/>
    <dbReference type="InParanoid" id="A0A401GQR5"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="295" mass="33709" checksum="B604AB2B7C5F4B4E" modified="2019-05-08" version="1">MPDGRTRKVRLDQISENDVVVAVMGPTGAGKTTFINAATGQGDYLVGRKLRSRTAKIRTTRYVHPAYARPIIFVDTPGFDDTSKPDTDILRMVADWLVMVYSRNIKLAGVIYLHRISDNRMSGASQKNLRLFTQICGDSAMQNVTIVTTMWNSVREEVGTSREAELRNKFWRTMLEHGAETARYQNTFNSAWEVLDRFTRNELSVLQLQMEMVDSNQLLRDTQAGIALYLQQSLAERENSIRRHRETATIENDSGQLQQLDAQLAAIEETRRSFYESLETRSSLGRRILKFLTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRD9</accession>
    <name>A0A401GRD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615711.1">
        <property type="nucleotide sequence ID" value="XM_027759910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRD9"/>
    <dbReference type="GeneID" id="38781715"/>
    <dbReference type="InParanoid" id="A0A401GRD9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="129" mass="14219" checksum="2E4CE18183C9CB36" modified="2019-05-08" version="1">MSSSRPRVREWQTWRGGATSRAEFRSDKKGTVRSVRESGKKQAVPTKAHRLDKEVEDEPEVQWRTSMDTAGRTKGEALVLDDSGGGDGEMTGVLGRGETSVAKGGIRDATPRASVAKCERCICMYRFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRS1</accession>
    <name>A0A401GRS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615763.1">
        <property type="nucleotide sequence ID" value="XM_027759962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRS1"/>
    <dbReference type="STRING" id="139825.A0A401GRS1"/>
    <dbReference type="GeneID" id="38781767"/>
    <dbReference type="InParanoid" id="A0A401GRS1"/>
    <dbReference type="OrthoDB" id="2800603at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57053" checksum="1F476C26AB70EB67" modified="2019-05-08" version="1">MPADLWKVIIILGDNKGSLPNGHYISFVRPLLPSDFSRFVLYASRIRRLGGDRWEPSLRPLRPYRVSAGVYYALKDYRPSSPLIPNLEYLGWSGMQSRDPEVFRCLHMFYGSKLRTVKLKGPVVQAEEQAHAALRGLARICPQIEELQVNIGLYARFALADVICGLHNLTRLCCEDTAISLQPMMHLAALPALQILSINVSAISDPIQLSSTLDDGPQGKFVALRRLYISAWSVPILTAFLNSIRSSKMIELTTVAQEATSPEVAEEFFTALSLHCSSKQIRLLSFTFNVKQADQADQADQPECALTNRTFLPLLALPRVRKLVIDVNCSLHLDNDFLASMSHAWPFLWKFEFGLVRPWVQRSPQATLAGLVPLAQNCKHLLSIGMALDTRLRRRGFDLERRPGLGVCSASLQDIHVGGSMVEDPAALAAYLSDLFPKLWWIGHSWPSEEDEGEHIQEEWEMAERWREVGRLVKAFVDIRQQERKWAASADAQMATSSPSPGHSPMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRX7</accession>
    <name>A0A401GRX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0604630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615397.1">
        <property type="nucleotide sequence ID" value="XM_027759596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRX7"/>
    <dbReference type="STRING" id="139825.A0A401GRX7"/>
    <dbReference type="GeneID" id="38781401"/>
    <dbReference type="InParanoid" id="A0A401GRX7"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="941" mass="106390" checksum="41999033A9205670" modified="2019-05-08" version="1">MPLNRAESLSFTSDSSRSDKSTLSDTLELVDDPYTREQHKVFGAEVLEMCKSFGLTSELVKNSRISAAALLNKILLQCKEDMIPEAIDIEFLGKLLQQNDQLRIELSKALKDEDFCRILCIKILRRTKPTTGGANQRFYSITMQKQATMAAWYSPYIGNAHVALLDAIKEMNRTRGDQGYANYVPIIQSSGTGKSRVVDQLASLVFTVPFNVREENVESGHPFPHPDDAIRAHLLDVCSNSPKESEWFKLDVVAAYVKFFEQLFIVVREHLDQRMPHYRKKYKSSRELAAAWREYLNPQQDSVEVNGQREVLYSDVVSRLEKREPAGIGKNLKDHAQNAIQQGQALVETVNRLTNRQPERHDLRIVLYFDEAHSLSDAYIGETNRYDALCSALNQLRTLPIFCITLSTNSNLTKFSPPQKRHHSARVVEGLSDPLQPPYTELPFDCLPEGKPILGTKEKTLAEVADIGFMAMFGRPLWSAQLRGGVEKKWLLELARMKLMGMEKYTEDIDQSKRGLLAALSTRLLLDFEPTREVSRSMEAQLVEANMRIAYSVPKHREYVRSGCPSEPILAEAAAQAMNELKRTVPEQLADFVVDGLIGKGEKGELVMRLLLVQAYDKAAKKTCERDQVDLSFSRSVHLFDFLEALFGPKNLKILKQSCPDNDSRGKKFEDAFKHAQVRFTHFARNGDESSSTSYGAYAAVVRGMAIQCSTNQDVIDCIVPVVLQDDKLSEKIMSGILIQVRNKERREVIVVDEATIRHGKGFFPKGRRVDDRPYITISMQLGVQTKASKTALSQTPNASADKGRKGVLSTPSRFTVQGRSPHHKRGVHPRYPISVIGYSKKVFDMVDNKHHYAVLLGGRDLLDEHPRQADVYLTFVRRLKPYWKVGSHCYDWIDEKELNPARVQEEEVPDEETFLVGEDAVEEQTGMIGEDALDDNDPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS83</accession>
    <name>A0A401GS83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0702490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615976.1">
        <property type="nucleotide sequence ID" value="XM_027760175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS83"/>
    <dbReference type="FunCoup" id="A0A401GS83">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS83"/>
    <dbReference type="GeneID" id="38781980"/>
    <dbReference type="InParanoid" id="A0A401GS83"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="72"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="276"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="533" mass="57875" checksum="69F8D3033DA6F8E1" modified="2019-05-08" version="1">MFTPFSIDLLPMDQVIENLWIGDLSSALNTPMLKANNIHSVLTAMRGRLSIHETFIRKQVNLDDTEDADILVHLVSAISFIEEELEKGHGVLVHCHAGLSRSATIVAAYLMYAQEIDAPSALEVIRKARPNVQPNAGFLEQLDIFHEASFKVSRRDKATRMFYLERVVRDVMSTSSDSDSDSFFLYNEFLYPDGDGSVETDMFAKYPRTPSDSAPATPAGPRRRIRCRMCRQELATREHMLDHGQLGPPTPASLSAVSPAASRRPSMHDGKPFNVLSPLSPISPPGSRRPSMLGNRPGSSLSPMSPPASRRPSTHEPAIRSRLNSNADNRPLKSSLLALDGAAQFGHDLSDALQLSESALEGDDDSVDEEFDPAPAKPERKSAAVVNLPLITPSASSSSESGNLPSVARRPSASSRSSSFAHPSDLAAQLYANPKLAALRRPSLSALNMSPISPAGPSNGAKAVPFSPPILANPKCSGYFVEPMKWMEPFLEEGQMAGKIVCPNKKCGAKLGNYDWAGVCCSCHEWVVPPVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSA7</accession>
    <name>A0A401GSA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0703070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616034.1">
        <property type="nucleotide sequence ID" value="XM_027760233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSA7"/>
    <dbReference type="STRING" id="139825.A0A401GSA7"/>
    <dbReference type="GeneID" id="38782038"/>
    <dbReference type="InParanoid" id="A0A401GSA7"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="30216" checksum="79D8360EA0A3A39E" modified="2019-05-08" version="1">MSPRVWFITGSSSGFGRTVTEYVLKSGDIAVATLRNPSALSSLSAVYPASKLLVVQLDVSNTPAIAVAFAKAIEAFGRVDVLFNNAGYGVLSEAEGAPEEVARALFDVNFWGAANVSREAVRIFREVNSPPGGRILQNGATSVFKGIPVLSYYVATKTAIDGFTKSLAAELDPEWNIKVTIIEPGAFNTDAAERSMVHLPAHPAYTKPGGVAALMRAHLMQPNLKLAGDATKAAGVIYRVAGIPEPPLQFPLGKDCIVMVRGFVNGLTETIDKYESWSEGLEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSB3</accession>
    <name>A0A401GSB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0702450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615972.1">
        <property type="nucleotide sequence ID" value="XM_027760171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSB3"/>
    <dbReference type="FunCoup" id="A0A401GSB3">
        <property type="interactions" value="586"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSB3"/>
    <dbReference type="GeneID" id="38781976"/>
    <dbReference type="InParanoid" id="A0A401GSB3"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="51"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33629" checksum="90F130C1B97804E9" modified="2019-05-08" version="1">MNGPEAFRRFAQQVQRASQGGGGRMPSGKGLTAGGGLLIALIGGGLALNASLFNVDGGHRAIKYTRLNGVTETVYPEGTHLMIPWFETPIVFDIRAKPRNIASLTGTKDLQMVNITCRVLSRPNPSSLPTIYRELGTDYDERVLPSIVNEVLKSVVAQFNASQLITQREMVSRLVRENLTRRALRFNLVLDDVSITHVAFSPEFTHAVEAKQVAQQTALRAAFLVDQAIQEKQSIIVRAQGEAQSAELIGDAVRSNKGFLQLRRLEAARDIANLLAASGNRVMLDSHSLLLNVTEDASDLLQFNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSS4</accession>
    <name>A0A401GSS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0704050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616132.1">
        <property type="nucleotide sequence ID" value="XM_027760331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSS4"/>
    <dbReference type="FunCoup" id="A0A401GSS4">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSS4"/>
    <dbReference type="GeneID" id="38782136"/>
    <dbReference type="InParanoid" id="A0A401GSS4"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="58"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="476"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="412"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="629" mass="69923" checksum="410BB7875313721D" modified="2019-05-08" version="1">MSEQYSPRLSFTDAGSLPSDSVSRSDPGDISAASSSRSPSHHRTLSRVTAWLRACPFASGIIRDVSSRAPYYVSDWQDAWNYRVIPAIVQIFFANVLPGIAFSLDLIETTQQYGVSEVLLSSFMAAFVFSAFGAQPLCIAGVTGPITVFNKTIYNIIERHPDPPEYLHFVGWVYLWGAILHWITAALNWCNFLKYVTLFSCDTFGFYVAWVYLQYGVQVVTREFSSSITSASTLDGAFVGIVLALLMLVTSFVFRSLSQSPYFHRHVRRIFADYGMPVALIASSAMAYWGRFNQANPSTLPVGRAFQPANGREWLVRFWQLDGKWVGIAFPFGFVLWVLFFFDHNVSSLMAQSTHFPLRKPPGFHYDFFLLGITTFIAGLLGLPAPNGLIPQAPIHTTSLLVMGYPSKRDAENVEESGSSFPRPSQTPNEQLRPEKARQQDKHEREVQHIHSRQPSLLEPDPARPLSDTSFKEVPVAVVEQRVSNLAQGALCLVLLTGPFLHVLNLIPRGVLAGLFWYMGIDALQGNGITRKILYFFRDKALTPVDEPLRRVRKSRILLFVSVQLAGFGAAMAVTQTIAAIGFPIIILLLIPLRTLLIPRLPFSDEELAILDGPTASPFTMESVGGTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT31</accession>
    <name>A0A401GT31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616279.1">
        <property type="nucleotide sequence ID" value="XM_027760478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT31"/>
    <dbReference type="GeneID" id="38782283"/>
    <dbReference type="InParanoid" id="A0A401GT31"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10318" checksum="D45E603943F471AC" modified="2019-05-08" version="1">MYTDEDKQRVEQDSMRAEEAEKQARAAQEEAEEALAVAAEVAEDARNTQEAGQKLKVEIPPVVYVTDVTLGRGAVTCQISGREIVTAPRSEQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTD7</accession>
    <name>A0A401GTD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0800020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616398.1">
        <property type="nucleotide sequence ID" value="XM_027760597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTD7"/>
    <dbReference type="STRING" id="139825.A0A401GTD7"/>
    <dbReference type="GeneID" id="38782402"/>
    <dbReference type="InParanoid" id="A0A401GTD7"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="66"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="609" mass="67953" checksum="46008BDA3BE9252A" modified="2019-05-08" version="1">MSSDSDFTDIDEEEIPLSSLISSRKKGKTADGKDMYKIKGALKVPRTTTYTTQALYDQLHLSDIDLNADYQRGVVWNDTKQTGLIDSIFRNFYIPPLIFVVKYGDDGSERRICVDGKQRLTSIYRFMDGLIPYKDAFTSERFVFKETGKTKGKLLPERYRKIFSNKQIVCVEYQDLTEDDEREIFQRVQMGMALTPAEKLQAISSPTASFIRELQDQYVVDELAQTLDWDTARAGDFRGLASAVYNMNKWPALATMASLSQVEKWLRQPAELEERFCDQAHATFHIFVLLARDSQYNKAFRLTGVKKVSPVEFMAVTLLIFVYKNKLTLAQLSEAIATMRREIRANEVDIRMNARVLKQLLAFIKELNPAKLAPDRGQPPAGKLSNLKRKRTARAQGHDDADYVPPRRPAPQQLTASQAHSPWLPPKPEPSTSRPPSGPRRPSSANYQSATPSGPRRTPSQATAPPSTRPSSDRLSAIKDAKDNSPPAPSPRPPPTGPALRIPSTNFVGPSRPMHSPSLPFSSHSPTLPYPTPPSTLPPPPPSIPPPPPPPARYDGLGDSLMARMMSRPMAPPQNGRDIHQQQGRPASAPGPLPQDRYGTGRGDWRGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVH2</accession>
    <name>A0A401GVH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617096.1">
        <property type="nucleotide sequence ID" value="XM_027761295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVH2"/>
    <dbReference type="GeneID" id="38783100"/>
    <dbReference type="InParanoid" id="A0A401GVH2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8737" checksum="7AC76223AE37C3FA" modified="2019-05-08" version="1">MSRAIRDRGLCVGTWLAEWREERRKDIDEKARMRVGLSSSGRRGSSSWRPALQGIVSSRSYPKNGEQAYVHENDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW09</accession>
    <name>A0A401GW09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0902590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617293.1">
        <property type="nucleotide sequence ID" value="XM_027761492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW09"/>
    <dbReference type="GeneID" id="38783297"/>
    <dbReference type="InParanoid" id="A0A401GW09"/>
    <dbReference type="OrthoDB" id="2803809at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="301"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="842" mass="95616" checksum="86C2D242E3DDEFA1" modified="2019-05-08" version="1">MLQKFVNVSTDEFFNTFLRNPDGLASRKYTGAFKAMPEEGVPEEYLYLPFRKCLEDAKLCPGYQCVLTANAPDRDDKFKQKVDAALFLEKDAPTDGRQHWARQAISFEFKKSSMADDPFQDDKEDLEHDSEQGNKNRGQIISYAAETFARQHRTFCFTVIILGNCARIIRWDRSGAVFTEKFDYKRKPFILGKFLWRFSHHSLEAQGYDPSATMVTEGSDYYNLMTQYANTKLTSGDYVREFFKKSLEAGWPWWSLQVNDELPTPRDVEMGRLGVAVGAHTASEAPRATRPACYLVGKPHFIADGMVGRGTRGYVALDCQTSKFVFLKDSWRVDHEDIEKEGEVLRRLNDVNVRNVPTLVCHGDVLGQRTKTQDVWESVYGSVPVGNRPVKLHMHYRLVVEEVGHPLSDFKDGYELVSIMSDCLTAHRQAYERLRLLHRDISSGNVFFVERIEGDAVVPVGYLSDWELSKTVPKGGENHVARQPDRTGTWQFMSALSLQNPYKPITLQDDLESFVHLVVYEAIRFLPHNIPAINVGTFIWRYFDAAIPYNGEYYVCGDKKWSTMKDGELEDTSGKIIFGGHECYPLNVLLNSVSKWFSAYYAVLAREQPDLFRRDLIEVPAEQLAGEDSSDQPVKRRKKRAPNVGRIDFSKLVSRRDRLKEVQIQLVKDDAEELKDHYAICSAFDSILELGPWRENDKCPDKLPADYDLHKETQKVRAGSKRTADGPELLQSKKWKPSASGGKSAMIPLTDYRPGSDLPAPIREERHPLFPSLSRQTQVLEKRPASLSLSDEGERILSPAEQAQFASLPPLTPTATGAQTLHDSTNAQSSATRKRFRGCAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW32</accession>
    <name>A0A401GW32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0903170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617351.1">
        <property type="nucleotide sequence ID" value="XM_027761550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW32"/>
    <dbReference type="GeneID" id="38783355"/>
    <dbReference type="InParanoid" id="A0A401GW32"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="181" mass="20502" checksum="71F681A9F1B7326B" modified="2019-05-08" version="1">MSVQTWIPPESDPKTRHGLMDQPQDKGVLGRSEPKPGDNRRQYYRFLLRIATLNEFFSDYCKRKSVCLTWPDGRKLDPFWLGWKEFEKAVGCLVFPQPVTSGESDIAGPGKLPKDDGFCLAIAAHPQVNYLKKSNPTEEQINAIIKELNDCGLEVSRSDPLWYRGGILDIMWMPAGADSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWB8</accession>
    <name>A0A401GWB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0903380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617372.1">
        <property type="nucleotide sequence ID" value="XM_027761571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWB8"/>
    <dbReference type="STRING" id="139825.A0A401GWB8"/>
    <dbReference type="GeneID" id="38783376"/>
    <dbReference type="InParanoid" id="A0A401GWB8"/>
    <dbReference type="OrthoDB" id="2788977at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="213" mass="24069" checksum="F695ACCE5620A115" modified="2019-05-08" version="1">MLSDPGYADGTTSETMGRTEGDGSSELPIWEPGSLDAALATVSRRALQYEHQIQDLEAKLTLDLSNFRAIENLLQEVFAGLQQTQRRADIALSSTVPHISHSLDEDLMALHELDSQLPVILQQVRHIKRVYDHGRAKAHDLINALEWMNTPISLRLRTIIFTPNAPVSTRWKALVRTAFAIVFLVCIWIAWITLRGAVRAHRQRLVWGERLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWL3</accession>
    <name>A0A401GWL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0904950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617529.1">
        <property type="nucleotide sequence ID" value="XM_027761728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWL3"/>
    <dbReference type="FunCoup" id="A0A401GWL3">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWL3"/>
    <dbReference type="GeneID" id="38783533"/>
    <dbReference type="InParanoid" id="A0A401GWL3"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="180"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE86616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="426" mass="47547" checksum="97F056AFF0FD2494" modified="2019-05-08" version="1">MSEKKGRVLLAYSGGLDTSCILAWLIEQGYEVYAFMADVGQEEDFEAARKKALTVGAKKFFLEDLKREFVTELIYPAVQANCIYENVYLLGTSLARPVIARGMMAIADKEGCDFVSHGCTGKGNDQVRFELAFYGLKPDIKVVAPWRIPEFYNRFPGRQALLAYAAEKNIPVQQTASKPWSTDENLFHISYEAGILEDPDTTPPVDMWKLTTAPENAPVIPERISIQFERGLPVKVTVPGEGKTYTDAVDVFNALNALARKHGIGRIDIVENRFIGVKSRGCYESPAATILRIAHMDIEGLTLDRNVRALRDQFVTIELSKILYNGHWFTPEREFVISAIPSSQRTVNGVVRLKLYKGNVVVEGRSSDEGLYDEKQSSMDELGGFEPTDTTGFIQIESIRIKKWAQANIRKGQAGVTPKDVYGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXA3</accession>
    <name>A0A401GXA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1000310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617702.1">
        <property type="nucleotide sequence ID" value="XM_027761901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXA3"/>
    <dbReference type="STRING" id="139825.A0A401GXA3"/>
    <dbReference type="GeneID" id="38783706"/>
    <dbReference type="InParanoid" id="A0A401GXA3"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="170" mass="17686" checksum="4679040E268627EA" modified="2019-05-08" version="1">MDDRLSKQEAHNLIQMTGGTSFVCVPSETLVVSGSDDGSLMLWDVESGRELDTITEHTNSICALAVSPDGHTLLSAARDGLVLVWDVHAEGVTVRGRRDGHDGSVNALAIAPNGRTIAMGSADYTVSLWDSAAQGTTHVLRGHTAIITCVQFSAGGGRVGTAGADCLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXH4</accession>
    <name>A0A401GXH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1001700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617839.1">
        <property type="nucleotide sequence ID" value="XM_027762038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXH4"/>
    <dbReference type="GeneID" id="38783843"/>
    <dbReference type="InParanoid" id="A0A401GXH4"/>
    <dbReference type="OrthoDB" id="3263050at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59978" checksum="06F7E09C3DC017EA" modified="2019-05-08" version="1">MHYLGEIPQEILENIAFFTATADFLGPPVGVIGLLTANHRIHSALSISSNPHLWTRVFAYKFDLQSTIRRLGAGRISAVATADELKRRCILLKRIRSHPDTLTRTYELPTTHVEELNAILWMAYLMMLENEGKNEAQLCEYARLDLWLREYLFHALGASLIRWSVRMDMWPPTSNERNSLAMWLFWFLLKPEDYMVDDVTFQEAASVLKIIALGAHMYPLCFPSWRDFTPTCHAKEVSVVSHFSLNLRIVPPRISAPAILAYLTLTNRLPVSLDTLNYTKPAEPTLPSAVVARDSKEWDAEWARGLYLGSHTAKPLGNELSGAFLPGSLEGIWEGVFTYTEFTSYAALLSGASPGILQRSHIAQHPHLWRVREYHLYDEEDEDEDFNVKRKADVAPLSAGNPLRGYIPSRVDMQEVPDGLEFTEPGRSEPITYWRCRPDGPKRKVKDVFITGEGHSSWGQFKLIGRVRPCDGFISLSKEYVDSGRGKWVYRAYIVGNANGNLSGRWRDTLSPPDVLGYEGCFIMSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXW2</accession>
    <name>A0A401GXW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit H, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1002450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617912.1">
        <property type="nucleotide sequence ID" value="XM_027762111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXW2"/>
    <dbReference type="FunCoup" id="A0A401GXW2">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXW2"/>
    <dbReference type="GeneID" id="38783916"/>
    <dbReference type="InParanoid" id="A0A401GXW2"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13200" checksum="32B21F0B4314644B" modified="2019-05-08" version="1">MSLTVVRQASSVARAASRSCAFSTSAIARKDLVQELYLKELKAYKPAPAAKDAHLGAVKAYSLPPVPKPPTLPADLAAELSAYDAVEPVSAAAKDPVTSTEHVSTGADTFLAFLEADEPQEEKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY41</accession>
    <name>A0A401GY41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-hexosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1003830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618049.1">
        <property type="nucleotide sequence ID" value="XM_027762248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY41"/>
    <dbReference type="STRING" id="139825.A0A401GY41"/>
    <dbReference type="GeneID" id="38784053"/>
    <dbReference type="InParanoid" id="A0A401GY41"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="561" mass="60688" checksum="051C42E600816AA6" modified="2019-05-08" version="1">MEFAYVQPMTDLTEDIRREIGQHFVFGFHGHDVNDDIRILICDYFLGNVILMKRNVQSIVQVRALVRKLQLLAKEAGHKRPLMIGIDQENGLVSAFSLSFTDDAGTQFPGAMALAASGSPELAERVSHASGRELRLAGIHWAYSPVADINSDPRNPVIGVRSYGDDPNEVALYVQAVSRGLISAKIAPSAKHFPGHGNTHIDSHLNLPRIMTCQKDLAATELVPFQALVDSGIPSIMTGHMALPLITDDDTPCSLSRQITTGLLREEMGFKGVIVTDCLEMEAVASKYGAEGGAVMSLQAGADIVMICHQYSRHMGALEAAYTAVREGKLSIDALRVSGVRINALKDEFAGAWDDVFSSGLEPDELSRLKQENILLAQHAYARSVAVIRDPVGTLPLSTNGHAVLFTPRMESINLAVDDAEGKLRDSQRRLRNTAGPSYQAFAASISQRVLVPVKHIVYAPDEEISDSIKESLRAATSVIFATRNGLDHGEWQIGVVRRVVETVDSSKLALVSTCAPYDLLAMQGVNAPCLATFEFTVPALRAAVAVIFGETTAVGTVPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY48</accession>
    <name>A0A401GY48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1003680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618034.1">
        <property type="nucleotide sequence ID" value="XM_027762233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY48"/>
    <dbReference type="STRING" id="139825.A0A401GY48"/>
    <dbReference type="GeneID" id="38784038"/>
    <dbReference type="InParanoid" id="A0A401GY48"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="39"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="274"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="752"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="843"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="876"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="912"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE87121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113141" checksum="24E4F5E78BB27530" modified="2019-05-08" version="1">MATAYTRSPTALNPIRQQFLNSPPQRRPASRLHFVTEFSQCLYDFVVQLLPTPEELAVKEDVRKLLERLIRTIEPDSRLLSFGSTANGFSLRNSDMDLCCLIDSSERLAASDLVTMLGDLLERETKFHVKPLPHARIPIVKLSLDPSPGLPFGIACDIGFENRLALENTRLLMCYAMIDPTRVRTMVLFLKVWSKRRKINSPYKGTLSSYGYVLLVIYFLVHVKNPPVLPNLQQMPPLRPISKEDTHLNGYNIWFFDDIELLRQRWKSSNTDTVADLLIDFFKFYSRDFAYSTGVASIRAGLLNKESKGWQNEFEKTSLRERNRLCIEDPFEMDFNVARCVTKDGLYTIRGEFMRASRILQFRPERAIVALAALCEERKGEELLQASPSRAAFAPPRLPPQIPYTVGSSPMRPTGVPVPASVSPPEPAAVPEESSPGSPTPVSRPTPSAQVPIRLPLDQLEHMAPKRGKWTSPPPPEAPEEDRSAFEDRLGQGLARATAPSSAWVPYQRQGQGYSSSNSEVQTDDDARSDMVESDDVQSVHSFTEEGAIYRHRERLRTVTPGSEQQIQLLEAQAPQAELDRSNFASGSGAGSVPRAMPVSPQGHGGGGLDAKMLARLRGRPPSKVTQHLSKVNAVNLGARDMDEGFVPPHIDTPRRSLSGPSRTSNKFSQLALPTLVPTFPAPQAYIPNEQMHTASPAYPTAFIPNANVFYETTPTKDRMIHMSGYALPMRFTSSYQFYEHSPVLATSQPHAFALPGRSTPGSRSPSSTTSSPRQPNISPRHLPPSLRRMKLSEGVPEREPSVLENAVPLTMARSLSQTQAGYPTGTVSLQSQQYSLSLSPSLSQISLHSPPTPPHSQPFLHQHSAHLPHSTHSQPHSHAHPHMHSHQHQHSMHLHSRPHSYPRSLSPQPVSPFASPSSGSASCTSSQYAASSSPLSTSPLSLSHSDLPPQKPTVGDVNESEKTPIESQHPADLDAQVDCNLNDNVHPPQLQEVSHLTPGSLSLNQGVEEVLPMGPMESSTVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYG7</accession>
    <name>A0A401GYG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1001480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617817.1">
        <property type="nucleotide sequence ID" value="XM_027762016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYG7"/>
    <dbReference type="GeneID" id="38783821"/>
    <dbReference type="InParanoid" id="A0A401GYG7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="206" mass="23643" checksum="94506B3A9105501C" modified="2019-05-08" version="1">MSAQSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVRWEEGLRREMFAVRGICGDLALAGHADHIDHGGVIASVLTVCTFNREVLRPISIDVKAIPCPTTLVPRPKNLLEDSPDYWWKWDRQVGPAGSPMEAWWYKLGDPWEKVYTVSESILVQLEQLHVRVVNLTSWLHERTDQNLDVVLEELQEATRQLRELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ49</accession>
    <name>A0A401GZ49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618347.1">
        <property type="nucleotide sequence ID" value="XM_027762546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ49"/>
    <dbReference type="GeneID" id="38784351"/>
    <dbReference type="InParanoid" id="A0A401GZ49"/>
    <dbReference type="OrthoDB" id="3270804at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019526498" evidence="1">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="127" mass="13651" checksum="26BED5DA63FCC764" modified="2019-05-08" version="1">MAVSIVPMLLLQVNTAPLIAVPPMGSVTLAITLPTTITPTATGTVVLASTVSNIGPSLQTTSLITGHQWYTVTWGLEIGVFKGWTVVQPLVIRVTSSTFEKGPLYQDTWCKYCIMEALDCMQLLTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZJ3</accession>
    <name>A0A401GZJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1102490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618485.1">
        <property type="nucleotide sequence ID" value="XM_027762684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZJ3"/>
    <dbReference type="GeneID" id="38784489"/>
    <dbReference type="InParanoid" id="A0A401GZJ3"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8063" checksum="83123986311EEE52" modified="2019-05-08" version="1">MQATPYSQMPRGHQWILRAPCLISTSGGAVNVSLEAVCVFREINSPPGGLPLQNSCMAVFKGIPLLSYYGVVLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZT0</accession>
    <name>A0A401GZT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1103510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618587.1">
        <property type="nucleotide sequence ID" value="XM_027762786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZT0"/>
    <dbReference type="FunCoup" id="A0A401GZT0">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZT0"/>
    <dbReference type="GeneID" id="38784591"/>
    <dbReference type="InParanoid" id="A0A401GZT0"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="597" mass="64517" checksum="FD077876AC83665A" modified="2019-05-08" version="1">MSSTYVHYSTPSSLPSDYAILSRYAAAHPVEEEELVQEVAESTFETDEGVSTSALDIPSSSGIPISRRRSFPSSHIAPFNPTLGLLSDKHGFLSGPRPPNPSEITPLLAPPVPRIEEEVDERDAAGEPDTPVNMYKEEIGILTKYTLPVFGTHLFEYSLVIASVVSIGHLSTTALAASTLGSMTASVSGFSIVQGFASTLDTMLPSAWTSSQPNLVGLWSQRMVVVMTAVLMPILLVWFNSETILLSLKQDPEVAHLAAVYLKYLAIGLPAYAFNSVSRRYFQSQGLFTVPTRIILVVAPINAILNYLLVWGPESIRLGFIGAPIATAISFNLISIASIIYGVFFVPKTAWHPISLRCFTSVGVLVQLGLAGVGQTASEWWSWELVGLAASMLGPIALATQSVLLVSASTTYQAPFALSVATSVRVGNLLGEENAKRAGVAANASIIMSLVISLVWSAMFMTFRHSWAHLFNDDPDVVALVASILPLVALFQVFDGLGGVTGGILRARGKQFTGALLNLTAYYVIGIPFGIWLTFKHGLQLHGLWIGLTVSLVYCATVGVWICVRTDWDREVEKVRIRLAADQKRHHREDAEGGLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZW0</accession>
    <name>A0A401GZW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposon Ty5-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1103810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618617.1">
        <property type="nucleotide sequence ID" value="XM_027762816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZW0"/>
    <dbReference type="STRING" id="139825.A0A401GZW0"/>
    <dbReference type="GeneID" id="38784621"/>
    <dbReference type="InParanoid" id="A0A401GZW0"/>
    <dbReference type="OrthoDB" id="2801310at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="67"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="549" mass="62371" checksum="702DF07579FE4E73" modified="2019-05-08" version="1">MHDPEADEDLDNDPDKSNAELVYIAMSAHRNADADEPKMLSDAKRSLEWPKWEQAVQTELNQLQGMETWELVEPPEKPVGNKWVLVKKTNKEGEIIKYKARLVAKGYSQIPGMDYTETFAPVVRLETIRAILRLAAILDWEIGQMDVKGAYLNGTLKEEVYMRQPEGYSDGTYRVCKLKKTLYGLKQSGREWNIVLNRKLLDAGFKHLFSDPCAYIQIKGDKIEIVTVWVDDLLIFTNDCALMDQLKSELQNMFKVTDLGEPRKIVGIEIERDHSKRTIKISQTKYIESILHKNGLTNANMIGMPLDPNTVLEKEEPETDDECDRDNGYASLVGSLMYAAIATRPDIAHTVQRLSSFTANPGMAHWTAAKRVLRYLSGTRELGIIYGPIADVKPEDQAKFMGYSDADYANNIRDRKSISGYLFKLGNGTITWSSKKQTTVTSSTTEAEYRASAKAAKEAVWLRTLFKEIGFEQQDPTILFEDNTAAISIARDPQFHAKSKNFDVKHHYVCEKLRDKYIDIHYCPTEDMIADILTKSLPKPRHEKLSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZZ1</accession>
    <name>A0A401GZZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1104230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618659.1">
        <property type="nucleotide sequence ID" value="XM_027762858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZZ1"/>
    <dbReference type="GeneID" id="38784663"/>
    <dbReference type="InParanoid" id="A0A401GZZ1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="9608" checksum="5AF6F12A42EEF182" modified="2019-05-08" version="1">MKCPCNRPLGLLHRHPSQPSRGLRRVGLTSGDPFEAAQRDRSGGVFPGDEEGHGARMGGDSVEDEVWGASISTLDEDARKGHEAGRLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0J9</accession>
    <name>A0A401H0J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaphase-promoting complex subunit cut9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1201590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618846.1">
        <property type="nucleotide sequence ID" value="XM_027763045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0J9"/>
    <dbReference type="FunCoup" id="A0A401H0J9">
        <property type="interactions" value="844"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0J9"/>
    <dbReference type="GeneID" id="38784850"/>
    <dbReference type="InParanoid" id="A0A401H0J9"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="618"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="652"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="719"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="719"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="752" mass="84209" checksum="745D9791172BB11D" modified="2019-05-08" version="1">MASTPPPIHNFNVQPVPRLPSPSSSRPRHSINTSLSFGPQSLVNSFVEANSGTASNQRSFTLDPNRSLLPVSPLCSSPRLPRRTKTTSRHPLANDTTDVFQDDADTEGEGYEWKMVDRMRLWRHDALLQHMYDTAAFWGDKIVSITNDPNDAFWLAQTYFLTHQYSRAERLLTRPFPTSPPKPPNVPVAPLSNGHFQPSAPDIKGKGRETVVLPMATGTLVAPRLPVGPGEMIDVAVGFEEGVSRLVDMSVVCRYLAAQSQVRQGKWTDALEMLGEANPFRELERSGPAVPNLDGGVKIESSMCHLRGLMMLKLSRSEKAKHCFMEALALDVKCFESFEQLVRGEMMTPDEEWDFIQSLPYSDQIPEDAEFVKLIYTSQLRKYKHAEEHALTRRRLVDEYGLGDNPDVLYSFADALYTQFRWADCFAVTTRILGLVDVHAPTMPVHIACMHHLSHLNSKLFLLAHELVEKEPESPISWYAVGVWYLTRKKWTEARSYFSKTSLMDPRFGPAWIAFAHTFALEGEHDHAVTAYSTCSRMFTGSHLPLMFVGMEHIILSNQTLADEAFNAAQLMCDGDPLLINERGVMAYNHGNYEEAVLLFQESLKLAKVVQSSQQAWAPTYLNLGTSFRKLGRLQEARAAYQHVVEIDPRNQTALALLGLTYHLLGDIDAAVVKYHETLSIDPINGHVLELLDLALEASADAGPFGFKGVPGGEEDWARQMREHRDKGKQIAASRDMQGPVHVPKDDEMSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Q5</accession>
    <name>A0A401H0Q5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1202140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618901.1">
        <property type="nucleotide sequence ID" value="XM_027763100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Q5"/>
    <dbReference type="STRING" id="139825.A0A401H0Q5"/>
    <dbReference type="GeneID" id="38784905"/>
    <dbReference type="InParanoid" id="A0A401H0Q5"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="117"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="208" mass="22505" checksum="06E9E0A6EB9A302C" modified="2019-05-08" version="1">MSRNVLLQLALPLVETHGFTRQVLARSVLSLPTHEEPLSETAVSALFGNGSDARRTLINAWLDDARRQMKSAPSPALKDVLAFRLRFNEPVLSHLPEAFALLASPSTAFPPLDPMPALKHAAKVADEACYISGDTTVGNAWYARRASLAAIYAAAELHQLTSPHTAYTFLDGLLDTSSKVESSLGEADLFASYIGRSWAGIIKSRGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0S7</accession>
    <name>A0A401H0S7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1202590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618944.1">
        <property type="nucleotide sequence ID" value="XM_027763143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0S7"/>
    <dbReference type="STRING" id="139825.A0A401H0S7"/>
    <dbReference type="GeneID" id="38784948"/>
    <dbReference type="InParanoid" id="A0A401H0S7"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022702">
        <property type="entry name" value="Cytosine_MeTrfase1_RFD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12047">
        <property type="entry name" value="DNMT1-RFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="4">
        <location>
            <begin position="430"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="4">
        <location>
            <begin position="583"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="781" mass="89220" checksum="285235C07A718FA1" modified="2019-05-08" version="1">MSRRNRPTAFEVSFPEEAKEGPSRPGGLLAGHGAPKRKSPSADTINSEGKRQKIAQLAQDSRSAALPPPEVCYVPQPRDIKERKDFVVLGEDTDDEYEGTESKPIRVLSDFCIFDPKHGLQVVSLDLLDAGDYVGHFEAAGFVSPLFLNEEDAGQEDGIDDDEPASSLQRLRTSAVFRYTIDYAKVDDPVYIETQFGWYVLQEPSAVYRHSFLDFYERHRLLQIIISAAAENPLWTYQDFTDCYIGMHDQYLNRRLDETDIYSIIPQLRPALEDCEGGAELTAVPMIQHLFRGQKLAFTKHLDRAHAHPVTRHDLVGNIDLDVLRPEKQNRTHVTPLIDQLAAGFFQEHLEVVGPPPKVPSKHVLRQREHQARLQLFQLMEKTMQEKSKPIFHRSQRLHDEYWHAVSVNGEDYYVGEVIVTVAGAYHQRAEAELPDDLESLPDTATIADFFWFAQIVYINQKRKQLHVQWFEHSSQTFLQEISDPQELFAFNSCSDIDIDLVVGKVDVHWCIPRSTELPATEFYCNLLYDDNNASFTTVNQPNTAHTKNMLPPHNCSVCLLSAQQMEDQSWRKINDGIVHLGITYHIEDYVLVKTEDGPADIGQILDMHFSTTARQYESATITLRLLGRISNIIDLCPSDVMKDEHHLFLTDEKVTIPVELLLRRCSILHFDAIKDLSMWLSISPFHFFVRYHFVSPRPRKWVENTLLTFNDVHLCKECYKEDKKQMNIRKKFFIAARQKPLKAFDPFGGVGAFGLGMEEAGCLKMVHAVEISPSAAETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1X2</accession>
    <name>A0A401H1X2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1302460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619344.1">
        <property type="nucleotide sequence ID" value="XM_027763543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1X2"/>
    <dbReference type="STRING" id="139825.A0A401H1X2"/>
    <dbReference type="GeneID" id="38785348"/>
    <dbReference type="InParanoid" id="A0A401H1X2"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE88431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="515" mass="55953" checksum="2A399A465014C287" modified="2019-05-08" version="1">MSKYTPIDEIPQIHADLRAGFRSGKARSIAYRKQQLLQLAHLLKDNIDRFKDALQADLGRHPSESESAELAPTISEAMVCYHGVKKWAATERAAFSFNYAAMSPAIRKEPKGLVLIIGPFNYPILNLLAPFAGAIAAGNACMVKPSELPVQTCNLLIELFPKYLDQDLYRIVNGGVHETTKILELPFDHILYTGSHRVGRIVATAAAKHLCPVSLELGGKSPVVVDPKCDLKTMAKRLMWGKFSNAGQTCVAPDYVLCPEAFQDKLIEASKEVLNTFYPGDPQQDASFGRIITEQHAERLKGLIDATRGTVVVGGQTDVAGKYVAPTIIRDVPPDDALMEAEIFGPILPIVPTETVEEAVAFINSREHPLALYVFSPCPSFKAKVFDNTQSGSAIANECNLHVVVDGLPFGGTGASGSGHYTGKFSFDMFTHLRSTMDNPSWVDVITGLRYPPYKSRNSPLAALTTPRLPALPRGGASPKRWGLWLALLFAGVAAALLTKAGRNALTQLSLQLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2E1</accession>
    <name>A0A401H2E1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1303690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619466.1">
        <property type="nucleotide sequence ID" value="XM_027763665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2E1"/>
    <dbReference type="STRING" id="139825.A0A401H2E1"/>
    <dbReference type="GeneID" id="38785470"/>
    <dbReference type="InParanoid" id="A0A401H2E1"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="299"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE88553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="475" mass="52638" checksum="D5B492856F468EF0" modified="2019-05-08" version="1">MTTGATAQNTFIVAPRENDPYRYQAGFGNRFASEAIPGALPVAQNNPKKVKYDLYTESINGTSFVAPRAQNQFTWTYRMRPSVAHNGFTKLPDNPDLEANFHPSNPRVHFSPTQLAWSALDIPPANQKVDFVAGLKTLAGNGDPTSREGLATHVFAANTSMEKTAFCNADGDMMILPQLGRLDIQTEFGKLMVRPGELVVVQRGLKFKISLPDGHSRGYVQEIFGSHYELPELGPVGANGLANPRDFESPVASFDIDRSPWEIIYKVGGQLFVCNQDHTPFDVVAWHGNYIPYKYDLDKFAAMGSILKDHADPSIYCVLTAKSKTPAAPLIDFVIFSPRWDATRNTFRPPFFHRNCATEMLGIIHGSYGGRSEALVAGSLSYESGFCPHGLSYKEFKAGTEAPDTPQIVYADTLMIMFESCMQTTVTDYAMNRSGNLHKHDPEMWKDLKAQFLDHVDEINADLQTAGLPKLRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2E4</accession>
    <name>A0A401H2E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1400090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619518.1">
        <property type="nucleotide sequence ID" value="XM_027763717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2E4"/>
    <dbReference type="FunCoup" id="A0A401H2E4">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2E4"/>
    <dbReference type="GeneID" id="38785522"/>
    <dbReference type="InParanoid" id="A0A401H2E4"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="15725" checksum="070FFD816194B4BD" modified="2019-05-08" version="1">MNAPNRYELFVLEEGERPVEVTEDTKIPNAATIKILKQDHTLGNMIRAQLLSMPQVLFAGYKVPHPLQPHFLIKVQTDGSVTPAVILEQACTKLIGTLASLETKFKREFTFRDVDGAVAEDAYGTVTTGGAGWTEGRDYLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H316</accession>
    <name>A0A401H316_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619706.1">
        <property type="nucleotide sequence ID" value="XM_027763905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H316"/>
    <dbReference type="GeneID" id="38785710"/>
    <dbReference type="InParanoid" id="A0A401H316"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25456" checksum="CC7D2FBAABA90197" modified="2019-05-08" version="1">MSIPASPTLVNGVPSRAQTPFIRTSSPSPSIELSHASDEQEFATRLVSAIRVSVDFTDILVALRNRPQDRQAVVSMQRALEMVEWMQMARQELIAAEERTSRARTRVDQVWSLMRSTVTRTAQEIWREHGDEDIGHILGYTTNGIPASTPRSSPEPIPVRPRPPRSHVPSGRSPLSQPSFSTASTSSRRSHPYRNGRIPEQGSRTSRRTCYRCGGDHYVRDCPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H380</accession>
    <name>A0A401H380_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1402570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619762.1">
        <property type="nucleotide sequence ID" value="XM_027763961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H380"/>
    <dbReference type="STRING" id="139825.A0A401H380"/>
    <dbReference type="GeneID" id="38785766"/>
    <dbReference type="InParanoid" id="A0A401H380"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052201">
        <property type="entry name" value="LRR-containing_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24111">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="51128" checksum="7EB41403720F6F6C" modified="2019-05-08" version="1">MSYAVHGLDVALTSVAGAQEVISTILSRRLVARLILGHNELGDDGCEELFNFLRSDLGRKYKISEISLNSNKIGDRGLLVIARYLEGNTTLGELFLQNNDFVGDAEVVSSFTAALNSSRLETLCLSTNSGLSDTFASRFLPALDCPYLHELQISALGLTRTAAPYIIEYISSPRCRLHSLQMNGNRLGLRAMQAIVRAHCRSNFSIVKTEMYASLWADGSDDEHEVEVRVGEDRRTLWKESERLLRGALDRNKHLQRQTEREAFALLRYARATLLYPKGMHKAAESCRAGPSSGSDPCVSPSVDSLFSSIGTPVNILALGPPVKPFLFSLLPTELQLYILSFLAPTLSTSQRLRIVTYASSRSTLPPLLPSLYARDCPASYPVSQPSELSAIGGSRIRRRPPADVARSLCVRKSQTNRRQDERFRWLTEMKCDVYEVDPDMSFTHENDGAEGSLANGSPHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3K4</accession>
    <name>A0A401H3K4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027764137.1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38487" checksum="143398AAD8F0301B" modified="2019-05-08" version="1">MSCPTHNNASTLELQLERANFIGTALSAVAYGTHITLFVMTLRYYLRPIGRRDWLSLAYSVLLLSLATAGLALELQWDIVVFIDHGNCPGGPFTFLSQDSGNPTNVAMTSIFIVMNWLVDALLLYRICSIFCHKWSAWFLSILLLVALIAVGCAFLPDLAALGLDLRAHVRNPRCVAFLALSLSLNVIISCLILIRVLYLYHGIWNSFTGPTTCTSLVAVLTTSETVYSILTVAVIIVLAVDSPVQAAFLPILGQLQAIPPVITILRLVKRRHQALVTPPSVLQFKPTRGPLSPIDNDSGTISFPISFESTGPCHPPFEPEARVDLEAGKYDAHMDYLDSTLPHPLKVHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3M9</accession>
    <name>A0A401H3M9_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027764123.1"/>
    </dbReference>
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    <dbReference type="STRING" id="139825.A0A401H3M9"/>
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    <dbReference type="OrthoDB" id="3208947at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="633" mass="69946" checksum="A21A9CDE62753169" modified="2019-05-08" version="1">MSFVNLPEPATQATLADARRELVSDRLAVRVLSDKIQAAEDDLARIVEESRCAVRDMERERAALQEKVALTLAYISPIRRLPHELLRYIFLLNFEDYPCCAWVLSAVCSLWRRLVLSMPVLWSKIRLVTTQSTSADTIRLWLERSGTSVPLDIEIFLRSEPFSGIDLSCRRRSSSTSAHGWTYGPAGWTTTPSPLAHPGLGANAHATYVQVPQTAGIHFFPIAQAAQLVVANGVASAPSTASQEDPWDMPPLVSAERAPSLSRSKTSMHWGHIAFFYLVEQMRRWERFVFRFDKQFASFTALKAIEGDAPLLREFEVSCADSAFYHDWKWLPSASANSTFDISSLTTLTLHHVPFKWSAPMLRNLHSLSLRTLPTVHLALDRILYIIASNPELETLSLHFTSPNPPVLPLTPTTLQELKVLNLGGHYLLSTLVDSLILPSLDVLILDIDARDPIEDTVASLLARSNNPSLTRLSLAYGLGPGANSGFYYGGAGVASWHFLGELDHLLSLQIGSAPFEPLLATLGAPDDDPQQDHWICPNLRALAMRGCHHTHGDGVSKLVQMVEARNPEISAAGPVPYLGGVVAPARLRQLELYDCASLGPDVIKWLKTRIEDVACTEPLFEGSPRSPAYPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4D4</accession>
    <name>A0A401H4D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyrimidodiazepine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502470</name>
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    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassis</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="238" mass="26329" checksum="70914AC11DCC005F" modified="2019-05-08" version="1">MPESITLYSAKVCPFAHRVELALEEAQAPYTKFYIDLQNKPEWYAELVNPAAKVPALAYGGPAVPPDLPSSESFKLTESLVLIEFVADLFPDAHLLPADPVLRAKTRFFIDTVSTKLVSAWFPFVNGVASAEPFLNGVEQVVALLPETGFAVGVYSLADIAVTPFLARMFTALKNDLGLYPVGEGKKVYDILCGPRFARLQKYWQDVNSRSNFEATFDEAHIVEKYTTRFTRSVGGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4G5</accession>
    <name>A0A401H4G5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1503010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620206.1">
        <property type="nucleotide sequence ID" value="XM_027764405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4G5"/>
    <dbReference type="GeneID" id="38786210"/>
    <dbReference type="InParanoid" id="A0A401H4G5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="49" mass="5000" checksum="9E57EAFE828ABE40" modified="2019-05-08" version="1">MTYTANALWSNRSGSQADQAGLQSRGAGTRCQASRSPALGSPAMASLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4R9</accession>
    <name>A0A401H4R9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620340.1">
        <property type="nucleotide sequence ID" value="XM_027764539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4R9"/>
    <dbReference type="STRING" id="139825.A0A401H4R9"/>
    <dbReference type="GeneID" id="38786344"/>
    <dbReference type="InParanoid" id="A0A401H4R9"/>
    <dbReference type="OrthoDB" id="3204217at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="588" mass="63407" checksum="1FC24C8FDDC222ED" modified="2019-05-08" version="1">MLAVMNAAPAAFPFAGPSSSHPAPHGQKRPRGLWKGRRDSPASRPAAAEPPKAPASTRDSDLSDGDEDGRSYSSGSSKRRRFSGPDFSASSFSPFPSRPHTPYELGSPVAMTSSTKGKETCTVDFEDWQNLKALFTRAADRSDCDDAEEALPLLRAVIRECTRFLTVHRDPSVIFTETSARHSRSPDVLTPTDDRIARDWTHDAHTRPAAYREQPTAFHALFGSALFLTGNILAADPALALPAEPRDASAYWLGALDVFETGENLPSRTSGYGANDAEDWRMAIVWGRTLVALADEKVAHSIAVAKAAAGGGTDDNNYCYLPTLSPFSAAEPAWPPGSPFAAIAGVRPPVSRRALLHSASAHELLVLAMDQFSRGIFHMPHVHYAGSHNPPSQVYQPAPPPPRQRHHRQQQRQQVDPRFSRAKELFTLASEVLGVAERLPAAAQRAEWAAWADSVFTQMRMEAELDAWRAPLNAARGRCWLVVGEAAAEGVEGALEEGEGMDVLASREAGEAREGLGNAVTFFERARAAGARAPEDENTPLLVEALITLANLTVDAAAREELYARAQLEAGADLGLDADADADAMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5J1</accession>
    <name>A0A401H5J1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1700080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620597.1">
        <property type="nucleotide sequence ID" value="XM_027764796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5J1"/>
    <dbReference type="GeneID" id="38786601"/>
    <dbReference type="InParanoid" id="A0A401H5J1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="11407" checksum="5F0CE423A50F4BD8" modified="2019-05-08" version="1">MAIKRNEKSLGINGIKSTPRLHMGITRLRSVKRRKTPYLSRYDLLPLLVCVPLWEIEPVGLHVGRRLLGSELSERSYRKQSRLCLQVRPWGGYHREEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5V8</accession>
    <name>A0A401H5V8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl hydrolase family 92 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1701520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620740.1">
        <property type="nucleotide sequence ID" value="XM_027764939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5V8"/>
    <dbReference type="STRING" id="139825.A0A401H5V8"/>
    <dbReference type="GeneID" id="38786744"/>
    <dbReference type="InParanoid" id="A0A401H5V8"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019098691" description="Glycosyl hydrolase family 92 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="3"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="123" mass="13106" checksum="E21DDD5A0A549352" modified="2019-05-08" version="1">MTGAMASYVTFFLAGLYPVPATRQYLLSSPWFPQISFYNPAFNTTTTIKANGFSGNPANGTGGQVFVQNVTIDGVPWKSNCYLEWDVFESGSTIELELTDDANVVCGADDSALPPSLSTGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H629</accession>
    <name>A0A401H629_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1701660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620754.1">
        <property type="nucleotide sequence ID" value="XM_027764953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H629"/>
    <dbReference type="GeneID" id="38786758"/>
    <dbReference type="InParanoid" id="A0A401H629"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="83" mass="9340" checksum="1DC56733C1D68941" modified="2019-05-08" version="1">MRLQDVVSRYPQCGHDADEAELLSKELRALHLLREHTQHSVELVESPDSFDVAAKSGTPDKGSAFDTKENSKFESIKILYRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H643</accession>
    <name>A0A401H643_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SCP_1702420</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620829.1">
        <property type="nucleotide sequence ID" value="XM_027765028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H643"/>
    <dbReference type="STRING" id="139825.A0A401H643"/>
    <dbReference type="GeneID" id="38786833"/>
    <dbReference type="InParanoid" id="A0A401H643"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0229">DNA integration</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="20">
        <location>
            <begin position="304"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="858"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="1157"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GBE89916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1211" mass="138983" checksum="BBD0C0D805B4F8B5" modified="2019-05-08" version="1">MNADGTPNQMGTITHCTWKMMKIRGRKTLTRFLLTGIGKENILLGMPWLKRLNPMINWETGDFWFGKEAKWPPKPTVEDAPDKEVSIFKEDGLSELIITETSPTLFGHSESIREIMTDNTERGELPAVRNDTELDDLPSESPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYIRLSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVRTRRVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKVKPFIVESDASKFATGAVLRQADINGDLHPCAYISQTLNPAEWNYEIYDRELLGIIRALAEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSRRNGLDDSESDNEDRVLLPNALFVRSISPTLFDEIRNHAAKDLIVHEALEAIAHKGPFPMKSSLSDWEVHDGVILYKGKIYVPPSETLHRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPISNGFDSIMVIVDHDLTKGVILMPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLRLYCGNNPETWADRLPDLEFCHNTREHSARKMSPFYIMMGYEPRGLPSVFPSTNIPSVEFRLDMLQKIRLEALAMHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYMNPPPDVVDNEEEYEVEAILNHKTYRGHLRYLVKWKGYSSAENSWEPTHNLQNAKQILDAYKRTRGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6G2</accession>
    <name>A0A401H6G2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620853.1">
        <property type="nucleotide sequence ID" value="XM_027765052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6G2"/>
    <dbReference type="GeneID" id="38786857"/>
    <dbReference type="InParanoid" id="A0A401H6G2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="225" mass="24715" checksum="148F560F280AF264" modified="2019-05-08" version="1">MPPPPRHMPPGPPPRSGAPGSLTGPTSGPPAGYILRPPVGPAPAPVKSHMQRAYEHLDNDESESEPSTTDDDNEPTNAEVQRLNKQHQRNRGPMNLPRQGVSRSDDKGKIVPWPSDTDNDVSLAPHNWPDTFPYRSTRSHERRPSGTTLYPSDRPHLVDAARWTLDRVPWHDEPAHVMAMSQQLWSDISADGSTSQPDDQPHQLIDIRQVGGVVCTEPEPGSLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H700</accession>
    <name>A0A401H700_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1900410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="38787109"/>
    <dbReference type="InParanoid" id="A0A401H700"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27731" checksum="988ABE2808AEDE4E" modified="2019-05-08" version="1">MGESSPAVSSINSEKDAALIVSTTGQSVRTILVKDGAHTTWQWLVFYIYTGQIGFAPLRSQGTRRRMVERERYRSEYPQRPVLCSPKSMYRLADKLGMDALKILAANDLRMKLSSENILDELFSQFTSWYPELLETQVESFCDNCIGSGILPALEQKISAIVAGRSPHADAALTRLFRAWVGRAPTPKRMPALSAVLQSIPGGTSRKRNTEVKKHLHLLVSRCANRMSIFLPPPFPVGGYIGSGDGYLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H7B8</accession>
    <name>A0A401H7B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_2200020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000022">
        <property type="protein sequence ID" value="GBE90281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621194.1">
        <property type="nucleotide sequence ID" value="XM_027765393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H7B8"/>
    <dbReference type="GeneID" id="38787198"/>
    <dbReference type="InParanoid" id="A0A401H7B8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="934" mass="103329" checksum="08EB44DCA4D6709A" modified="2019-05-08" version="1">MQQRLAAPSSLLPRPREAPRNPIPPPCTLLRASSTHARPQGRTAARRTPTTPPRIHLLPSLTHIRLWEGEPEDRGLLHRRTETFDRAFILEGCREPSVVVIASATVLQRLLPAPSSRSPDPDAGPRHLPAPSPDPPRPAEARRWLASPPSTIRRPLDLQRPSAASDSTAVPTPAAAIQRPRRPPFSRSPSPDVLCFRELRDEHVFVIIYAVVASYFVCVMRSGLAIKHNGRRGVGKPPPNKRRLDLASRSSCLAHRRDTLPQRRGGSPRRCSAFIYSSPASVPRPFRFALERGASAPRSRRHLHPPPSTSRCPTPSNANVRRRVRSRRFKGTRVPSSSHRPPRWNGRHLVVPKVPICSRRSKSAVQPHRCRSGHRGAIAARCTPLAVAETPRRPTAPPRPFPAPSPDPPRPSQARRSEQRRPGRSTRLPFRLALPQAIERKRSAVRLFWAVEGKSSHVVVAPATAVQQHRVAPSSRSRRPLATPHHLPVSSPDPLRTAQARGGERRRRDGRAGHRGATKARSPNCSVAKAREAPGSLSPPPSTLHRPSSTRAGPRRPRSAWPCEGPAHLCPSSLHPPRHTQAHDGERRHPRRHTGYRGATTACSPNHAVPKAPRGSAQPLTTSSHPPSTLFDARRPTTANDGTAIIALATAVPQWRQAPSWRSPATGESPRHLSAPSPNLPRPAIAVCSERSRLDRDAGHHSATTAPRSLLAVCRPRRWTPSPQPTFLDHVRHPQRTIALRSSGWPLQWNDHADRPPRGLQAPTLARITFQNPHPTLFDARLPSVVNDCPPDLPCNIERRSLDQDPPRTLKRNAFECKFAQHCSGSVARRPRTIHRRPRPREQATTAILLLSTPPSSSWRSPRPSNATVQRHVCFRRSKGILATSLSRQPPRCDSGMQPRPRGRGGPAKPHHTRLHLPAPFVDPPLRAQVHHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Q4</accession>
    <name>A0A401G4Q4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608056.1">
        <property type="nucleotide sequence ID" value="XM_027752255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Q4"/>
    <dbReference type="GeneID" id="38774060"/>
    <dbReference type="InParanoid" id="A0A401G4Q4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9252" checksum="289F057AB469DA50" modified="2019-05-08" version="1">MKTPNTDCTRPPGQVASLASKKDGMQQGALGGVLKRARIHQEPGVQVLSPVRRGCDGLLQQSISVAGDLTAVPCRAGAWIVRSTDWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4W8</accession>
    <name>A0A401G4W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein AIM2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608139.1">
        <property type="nucleotide sequence ID" value="XM_027752338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4W8"/>
    <dbReference type="STRING" id="139825.A0A401G4W8"/>
    <dbReference type="GeneID" id="38774143"/>
    <dbReference type="InParanoid" id="A0A401G4W8"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="249" mass="27723" checksum="BDF3DBAAFD11F367" modified="2019-05-08" version="1">MATLATAPSNCCIKTVEHTGTARGTIEKIAGIDTYIVGTADPQDSRKIILFFADVYGPIFLNSQLIMDYWASNGYLVLAPDYFEGDAAGKYVGTPGFIMRDWAKPKMEKAVLMIPPWLKAVREQYDSTNTKWVTVGYCFGAPFVMDCVASDWISAGALAHPAYLDEGHFRRAKKPLLLSCAEIDHTFPAMNRRRAVDILVENKTKYHVQVFSGVTHGFALRGNVNDPIARWAKEKSAEGILSWFDLFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G509</accession>
    <name>A0A401G509_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear receptor 2C2-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0101160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608156.1">
        <property type="nucleotide sequence ID" value="XM_027752355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G509"/>
    <dbReference type="STRING" id="139825.A0A401G509"/>
    <dbReference type="GeneID" id="38774160"/>
    <dbReference type="InParanoid" id="A0A401G509"/>
    <dbReference type="OrthoDB" id="10052260at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16610" checksum="663C067761553AF5" modified="2019-05-08" version="1">MDSKFRSLLTSETRIKVSSTLDNSVGKKCLTDGDPETCWTSQQGTPQSIQLSFPSPVIPRKIALTFQGGFVGTRCSVQVLPSQIGLEKPKWQSYSQIFPEDVNRRQNFDLPVELLQNGVESLKLVFEESSDFFGRITVYDLQLEGECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5F4</accession>
    <name>A0A401G5F4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0102630</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608303.1">
        <property type="nucleotide sequence ID" value="XM_027752502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5F4"/>
    <dbReference type="FunCoup" id="A0A401G5F4">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5F4"/>
    <dbReference type="GeneID" id="38774307"/>
    <dbReference type="InParanoid" id="A0A401G5F4"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="381"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE77390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="587" mass="66113" checksum="A909F9547FEE8055" modified="2019-05-08" version="1">MTSSEPTLRKRKRATERQSSRKQKQPAGSANGHPVKFTSVLGLLLLALGFFAYQNLEAIQRYLEAWRKSADWDAATKSSGPLEFSADLPKRNAVVVAFKHAWLAYERDAMGDDEYHPIGHSGTNLTDAGGIGYTVVDSIDSMIIMGLKDEYARARNWIATNMTFDRNGEFNTFETTIRVLGGLLSAYHLTEDPVFLERAKNLADRILPAFDTPSGLPLSSVNLAKRKGVPSKDNKELVSTAEVSTLQLEFKYLSLLTEEDIYWDVVENAMKVIKAARTSMSTGLASIFMSYDEGRFTVAPIRLGSRADSYYEYLLKQYIQTDYTEPVYRTMYDDAMSSVYTHLIKKTERAGLTYTSELIPERNRQGKINWRLVPKQDHLVCFLGGSLMLGAVTTGAVVQPVSVPPLAGELSEQGKRDWTAGIELVRTCMKTHETATGLSPEIVHFKIAGDHIPESNAPEDWYIKGARPDGPNSYDARYILRPETVESLFIAFRLTGDPKYREYGWNIFQAIEKHCRVESGGYASVLNVDRLPVEHEDKMETFLMSETLKYLYLLFDDASVLPLSKYVFNTEAHPFPIFHPMRRTGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5L0</accession>
    <name>A0A401G5L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0103260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608364.1">
        <property type="nucleotide sequence ID" value="XM_027752563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5L0"/>
    <dbReference type="STRING" id="139825.A0A401G5L0"/>
    <dbReference type="GeneID" id="38774368"/>
    <dbReference type="InParanoid" id="A0A401G5L0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18858" checksum="4D2F7F9C16A4FC40" modified="2019-05-08" version="1">MHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYHLKLPKTWRVHSVFHAALLSPYRENDIHGPNYMNPPPDVVDNEEEYEVEAILNHKTYRGHLRYLVKWKGYSSAENSWEPTHNLQNAKRILDAYKRTRGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5U4</accession>
    <name>A0A401G5U4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0104170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608453.1">
        <property type="nucleotide sequence ID" value="XM_027752652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5U4"/>
    <dbReference type="FunCoup" id="A0A401G5U4">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5U4"/>
    <dbReference type="GeneID" id="38774457"/>
    <dbReference type="InParanoid" id="A0A401G5U4"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="697" mass="75307" checksum="9141CD9072B5BD93" modified="2019-05-08" version="1">MAALSSTSNPDDPTAKQTAEDEHLLDVSALKELSRKSLIDALNAVNGAKTLVLDPTLAGPLGLVTEVALLKHHGVDKMFWLEPGPLSATTTNIVYLCRPLVKWVKILADQLKRHSREAQKHTYTILLVPRMSTLVSRILEEEGVLGDVTVSSYNLQFIPLAEDVISLECDNAFKELWVDGDETVIYNSMQALITLQKLYGLFPRVVGKGDYAGRLAKLLTRHIVDISSGGGPAAQSDRMDSLIIVDRGADMITPLLTQLTYEGLIDELIGIKNSHVELPASLLTPPSAPNPVEPSASTSTQASTPSAPSLLKEKKKKHHLTTSTDPLLAELMDLNFSSVGRKLNQVAHRLDEDYKLRHQAKTVAQLRDFVGKLGGLQSEHQSLRLHTGLSEMLVPLTRTDQFNKSLEIQQNLLASYDVSAQISAIEDMIAQGADMQLVLRLLCLASIINGGIKSKTLENLKREILQAYGYEYLPLLLSLSAPSLAILLPHPLPASTPPSVLASKYPYTSLRKPLRLLIEDPDSVDDLENDISYVYSGYAPVSVRLVQCVAQKGGVLSNPATEKEKKAKDDPDGRKGKGPSLGKVQAHPIVGWKGFEDVVGSIPGDTVDIVQKVPGGPDSVNTAVASLMAPREQSATTVVFFLGGCTYTEIAALRWVGRQSRGRKFLIATTGIISGASLIDSVAGIERTAGGSKDAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5X7</accession>
    <name>A0A401G5X7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0104240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608460.1">
        <property type="nucleotide sequence ID" value="XM_027752659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5X7"/>
    <dbReference type="FunCoup" id="A0A401G5X7">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5X7"/>
    <dbReference type="GeneID" id="38774464"/>
    <dbReference type="InParanoid" id="A0A401G5X7"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="36315" checksum="7797D81DCFCC2802" modified="2019-05-08" version="1">MHFPSNSPFTEVHGFFLECVLLNLHLRRYPPARQYQYSFWKWAIRHLEELVVGEDAEIDPRIYSHLISVMPQSIPGNIGFPPPSETYATYFWKSEGIPHGATALDRVTVLESRTVIESGTTGLRTWLASYVLAHYLILHRALVQGRRVLELGSGTGLLGLVIAALQQHPGQRELAPPSTLWLTDVNSAVLQRCQDNIRLPCNSSSRHPNLKCRLLDWTDAVDPLTRPSVQTSLAEMDLDVVAGADLVYDPSIIPALLETLHLALESRSTPPPAPQSRAVAFVALTVRNKETFARFSRAAGDMFLVEELDNGLNGADVFLHGPELDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G632</accession>
    <name>A0A401G632_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0105060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608539.1">
        <property type="nucleotide sequence ID" value="XM_027752738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G632"/>
    <dbReference type="FunCoup" id="A0A401G632">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G632"/>
    <dbReference type="GeneID" id="38774543"/>
    <dbReference type="InParanoid" id="A0A401G632"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE77626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="679" mass="77585" checksum="256EF14D70639DBB" modified="2019-05-08" version="1">MAANIQTIHFRRPEPKTTPAPIVKPKNRHAGILQDQLRRAQRGPWCPSFSTALKIFLLIRVAGAMYSNIQDCDEVFNFWEPLHYLDRGYGFQSWETSPVYSIRSWAYTMLHLLPTQIAKLLVGGEKRPAFFAVRLTLAAISSVCETAFYRAVVERINYRVGRYVFFMLLFSAGMWTASTAFLPSSFAMYANTLAFSFALEPSGSSNMKRTLFATLSFAAGAIIGWPFALAVAIPFVFEELFMFGADRVPPELKLSWMLKRWKRMLVCGAVASLLFIPVVALDTLFYGKLTLVPWNIVKYNVFPDSQSGPDLYGTEPASYYLSNLLLNFNVLVPLAIAALPALAITYRFDRRRLGERTPTADQSSPFILLAVRLAPMYIWMQVMTAQSHKEERFMFPIYPLICFNAAVTLYLMRGWLETAFVKVTKSPYRASISPLFRRFTLSVITAFCVLSVSHILTQWEYYHAPLTVIYSLEGEEIPRILNATGHIHLASPTDKVGQDQLEMEPRIDLNLIRPFNLRLCIGKEWHRFPGHYLVPDGVRVDWVKSEFDGMLPGHFLETYIDGGLIERVQGTRAIPTGLNDLNKEAPEFYVDISECDYLMDLDFPLHPVSSLHEPRYAADNATWERVKCKPFLDARNSWILSRTLWMPGSRWQEGNEFGDFCLLKHKKNVEKKEKAMMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6X3</accession>
    <name>A0A401G6X3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0107810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608812.1">
        <property type="nucleotide sequence ID" value="XM_027753011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6X3"/>
    <dbReference type="GeneID" id="38774816"/>
    <dbReference type="InParanoid" id="A0A401G6X3"/>
    <dbReference type="OrthoDB" id="3264102at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="10551" checksum="2CF26F090A218F9E" modified="2019-05-08" version="1">MGSLCSKESTLSEGQTVVPRPIKSTTRAVGQGPDSQAGHARPDPRIAAAEAAERRLKGQQARGTHASNPNRGKLAAQLEASKSAVRAPEPRQEDRLVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G776</accession>
    <name>A0A401G776_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pseudouridine-metabolizing bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0108850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608916.1">
        <property type="nucleotide sequence ID" value="XM_027753115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G776"/>
    <dbReference type="FunCoup" id="A0A401G776">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G776"/>
    <dbReference type="GeneID" id="38774920"/>
    <dbReference type="InParanoid" id="A0A401G776"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="6">
        <location>
            <begin position="313"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="580" mass="61947" checksum="2DE1336FABC5EACB" modified="2019-05-08" version="1">MPHPVNLETARTVEGIVREAGAIPATIGIIGGRVKIGLKARELEYLADAKAAIKISRRDIGPAIATGKDGGTTCSATLIFAALAGIKVFATGGLGGVHRGGETSMDISADLQELTRCPVGLVSAGVKSILDIGRTLEYLETLGVPVLSYAKTDDFPAFYSRRSGFKSPWKVDDPATAARILYTQRQLGMANGVVYGVPIPEEYEAIGQQLQSAVEQALKEAEQTGVNKRGKEVTPWLLKRVGELTKGKSLANNIALIKNTALIGSQIAIAYADMTRKDREDSRHLVSPAWTKNAASVRGEVAQPVEDVPLARAKLIVVGSTAVDVTAKANPTSDGSTALHTTTPGTVAVTLGGVGRNVAEAAHRILASQSEELSSATALISPIGNDSFGRLLVDEFHKSGMRTDGLLQVDDARSAVCNMVVDTDGSLVGGVADMDIINSLDTQKVIQTLEEHRPSLVAVDGNLTSEALKSLIDYCHQQQMPVFFEPTSVPKSTAVFPAIAGLLDRTNRPPITFAAPNLHELKHMYQEASSGTWELTAHKQWWTAIDDMALGSEFPRVPYHSSSPMGSRKWPFSFSRSFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7D7</accession>
    <name>A0A401G7D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bile salt-activated lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0109560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608987.1">
        <property type="nucleotide sequence ID" value="XM_027753186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7D7"/>
    <dbReference type="STRING" id="139825.A0A401G7D7"/>
    <dbReference type="GeneID" id="38774991"/>
    <dbReference type="InParanoid" id="A0A401G7D7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="188" mass="19231" checksum="E7A30FBDC301F148" modified="2019-05-08" version="1">MAVGPSLRTLPMVVGRWLYNSPSGGGPITQKYTYGGGPIAQNTTYGGGPIAQNTTYGAPVVMGPSLRTLPMAVGLSLRTLPMAVGRWLYNSPSGGGPITQKYTYGGGPIAQNTTYGGGPIAQNTTYAVGRWLYNSPSGGGPITQKYTYGGGPIAQNTTYGGGPIAQNTTYGGGPIAQNTTYGGRPMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7R7</accession>
    <name>A0A401G7R7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0110940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609124.1">
        <property type="nucleotide sequence ID" value="XM_027753323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7R7"/>
    <dbReference type="STRING" id="139825.A0A401G7R7"/>
    <dbReference type="GeneID" id="38775128"/>
    <dbReference type="InParanoid" id="A0A401G7R7"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019097092" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="143"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="442" mass="49923" checksum="FC4D9D72E0CB1BA9" modified="2019-05-08" version="1">MRLPSLTCLLSIVAGVLAATRNVQKRAVPAGYVTTNGTEFELDGEPFAFVGTNSFWLPLLTTTDDVDATFETMASMGVKVVRTWVSSLSCTSFVLILSKYLDVQAFNMINATELPGALESGLTYYQLWNNSDWTLNEGPQGLQRLDYVVDTAAKYDIRLILTFANNWFGYGGMELYIYWLLGPDSTHDEFYTDALTIASYQRYVQTIVNRYQNSSTIFAWELMNEARCAGDSLPSGSDCVPGSETLTTWYQLQSDFVRSLDPYHMITTGGEGQFYWAEPEYYWYDGQYVSDFNYNAGEDFEASLRLPNIDFGTYHMYPQTWYPELDYPGSNFSVEAWGLNWMYDHIATADVVEKPVIIEEFGALGLDNKSTIYPVWVNFGLESRHAFNSQGVRIQPWQFGMLNLTEDGGNRIIKYTDAISNGASPNDGKLFPTVQTPVFLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Y9</accession>
    <name>A0A401G7Y9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0111840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609213.1">
        <property type="nucleotide sequence ID" value="XM_027753412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Y9"/>
    <dbReference type="FunCoup" id="A0A401G7Y9">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7Y9"/>
    <dbReference type="GeneID" id="38775217"/>
    <dbReference type="InParanoid" id="A0A401G7Y9"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="231" mass="25336" checksum="F33405FA45691E90" modified="2019-05-08" version="1">MSEGGGLKQRRIVVLISGSGTNLQALIDAQNTPSLPATRITLVLSNRKAAYGLTRASQANPPIRTSYLALQPFLKANPGKTRDDYDIEIARIVVREKPDLVVLAGWMHIMGDGFLDVINGDRCLDPEENVAKPIPVINLHPALPDAFDGANAIERAYEAFQKGEVPKTGVMVHRVVKEVDRGTPVIVSEVEITTGEPIEVFEERLHKVEWEIIVQATAKVLDEVVPLYRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8H1</accession>
    <name>A0A401G8H1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0113210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609346.1">
        <property type="nucleotide sequence ID" value="XM_027753545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8H1"/>
    <dbReference type="STRING" id="139825.A0A401G8H1"/>
    <dbReference type="GeneID" id="38775350"/>
    <dbReference type="InParanoid" id="A0A401G8H1"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="49"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="375" mass="41791" checksum="0256A8C1DFCE7EB2" modified="2019-05-08" version="1">MTPPSTLPPLDSSIASSNLPSLLIDSAAPEPKPVYAHYHWKKKSPDGRVVYIRDAKTADDEISRLPPGPYGFDLEWKPKFVKGGRENPVALVQLANSDTMLLIQVSAMSAFPQKLHEVLQSADYVKTGVGIQGDCRKLYADFAVTMRNCVDLSLLARSVDNPRWKGRYASPIGLSRLCETYEELTLSKGKARLSNWEVDLSQLQQDYAANDCHSAFVLYRKLVSMAMDMASPPLAVYYTFNVVQGRLCHPVTSLNWFPHNPEYDPGPPPPPKVKAEDAVLPKEKATSEPGVEVEYTSREIVVVPLAKNPTVSQHFKRRQRAQMSTDLSPVPPHQAEQVASFHSGSSQWPMPQQRRGAPVRSRQIHDAPPHKKPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8H6</accession>
    <name>A0A401G8H6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0113380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609362.1">
        <property type="nucleotide sequence ID" value="XM_027753561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8H6"/>
    <dbReference type="STRING" id="139825.A0A401G8H6"/>
    <dbReference type="GeneID" id="38775366"/>
    <dbReference type="InParanoid" id="A0A401G8H6"/>
    <dbReference type="OrthoDB" id="2751752at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17286" checksum="52F78D52C1255A6A" modified="2019-05-08" version="1">MVRLVDAGPSQYVAESETYKYIRPMPKCSLDSLVGHATRGCPVYDLQQRKVVYLKDTWRIFAEDLEKEGDILASLRTHNASYIPTVERHGDVLDHAMKTQALVYEPWNHAAQLLVAIQTGHLHYRLVLREVARDLTSFTNTNELCGGDRRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8K3</accession>
    <name>A0A401G8K3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0113830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609407.1">
        <property type="nucleotide sequence ID" value="XM_027753606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8K3"/>
    <dbReference type="GeneID" id="38775411"/>
    <dbReference type="InParanoid" id="A0A401G8K3"/>
    <dbReference type="OrthoDB" id="2756211at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9904" checksum="78D0C9625F922403" modified="2019-05-08" version="1">MYSTMQPIKLFLNRRFNRSVSCATDSRPSIDSFDSNEYVIQLPVSLIPKLASQSVTPQAGSLQRAQMMDEEDCAWGRPSKKNQGRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8S7</accession>
    <name>A0A401G8S7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leukotriene A-4 hydrolase homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0114690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609493.1">
        <property type="nucleotide sequence ID" value="XM_027753692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8S7"/>
    <dbReference type="FunCoup" id="A0A401G8S7">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8S7"/>
    <dbReference type="GeneID" id="38775497"/>
    <dbReference type="InParanoid" id="A0A401G8S7"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="12">
        <location>
            <begin position="478"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="274"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="592"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE78580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="636" mass="71260" checksum="859129B913145B55" modified="2019-05-08" version="1">MDPTTQANYDQIASSHIDFAWTVDFAQSIISGSATHTFNVKQDDVQQVVLDTADLSIEKVLVDGQPASYNLGPRHEVMGSALQISLPSTPKKGARFKATVFYKTTRESMALQWLAKEQTQGKTFPYLFSQCQPIYARSLAPLQDTPSVKITYTAKVTSVLPVLLSAQRISPPSDGPAHDGKVIGKDAVTYTYSQPVPIPSYLIAIAAGNVRYRSFPKAEGKAWTTGVWAEPEFIDAAYWEFSEDLNRFLSTAETILPPYRFGVYDILVLPPSFPYGGMENACLTFLTPSLLVGDRTLVDVVVHELTHSWFGNGVTQAHSTHFWLNEGWTTYIERVLQQLLHGPAERGFSFLIGSNSLKEALKLHEDRPKYQRLVIEFEKGEDPDDAYSTIPYEKGANFLLHLERKLGGLDVFLPYVKDYVSTFMGKSITTDEWKAHLFAYFEKHGGEEKVKVLNSVKWDEWLHGEGLTLPNTMVYDTALARQAYALAEQWDASRSEPDTSRLAFKETDLDEFNSNQKTVFLERLQSYPALPSVHVSFLGSLYGFTNTKNAELRLRFYQIALADPASDAAKGFAPAAVRWAVGDDGTGIIKGRMKFCRPVFRAASKVDKPMAVKYFSAFKDAFHPIARRLIEKDLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G972</accession>
    <name>A0A401G972_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0115980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609620.1">
        <property type="nucleotide sequence ID" value="XM_027753819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G972"/>
    <dbReference type="FunCoup" id="A0A401G972">
        <property type="interactions" value="588"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G972"/>
    <dbReference type="GeneID" id="38775624"/>
    <dbReference type="InParanoid" id="A0A401G972"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001135">
        <property type="entry name" value="ABC transporter F family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="198"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="521"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="736" mass="82223" checksum="A8D11AA4D455CCE1" modified="2019-05-08" version="1">MNVFSEDIAEEIRTNLPGTEEIIVQYISGYLLDLDDAAEDEDVLNITRNILESAVPSSFRKARVPALDKLMQTLAKMLAEPLSKRDERNKAGKDTKLVRLDRIMDLSKTAVMSNTIAFAEGVDLESINKGKASRVDVKKLEKQEAKLKAKIEKRSKRNLYEGSKLLDQHRKQQTYEEMFMKINPLDAATASKNKSKDIHLPSIDVNFGSNRILSGASLTLAHGRRYGLIGRNGVGKSTLLRHIAIREVPIPPHITILFVEQEIIGDDTTALDSVLKADVWRDTLLREEAVLNAKLAELDGEGDDKRFEDAREEAQTRLAEVHARLAEMEAESGPARAAALLAGLGFSEADQSRPTKSFSGGWRMRLALARALFVKPALLLLDEPSNHIDLNALAWLEDYLQTWTGTLLVVSHDRAFLDAVATDIVHQHSGRLDYYKGNFTQFYSTKSERDRNLQKEYETQMEYRKHLQAFIDRWRYNANRAAQAQSKIKILEKLPELHPPEVEETETFKFPEIEKISPPILLLNEVTFGYTPDKIILRNININVDLESRIAIVGPNGAGKSTLIKLLTGELKPLSGHVSQNGRLRVGYFAQHHVDTLIPTMTPVQFLASKFPGKTEQEYRSHLGNFQISGMTGLQLIGTLSGGQKSRVAFAVLSLQRAHVLLLDEPTNHLDIEGLDALMAALSSWNGGVIIISHDERFITTVARELWVCGDGSVSKFKGDVQAYKSLIVSGIKARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9D2</accession>
    <name>A0A401G9D2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ammonia transport outward protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0116340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609656.1">
        <property type="nucleotide sequence ID" value="XM_027753855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9D2"/>
    <dbReference type="FunCoup" id="A0A401G9D2">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9D2"/>
    <dbReference type="GeneID" id="38775660"/>
    <dbReference type="InParanoid" id="A0A401G9D2"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="226" mass="24159" checksum="4BFFD290764874C2" modified="2019-05-08" version="1">MSQLEKAEVNALPPQPARPAFTPVNAQFRKFGNPGPLGLFAFSTTTLMLSLFNVSARDIHIPNVIVGMTLWVGGLSQLLAGMWEFASANTFGATAFSLFGTFWMSYGTIYIPSSGILAAYAAAPDQLASGLGIYLFMFFIISVILTIASTRRSYGLIALFFNLSLTFLLLGVAELVASTAKHTVKGGGAFGIITAAIGFYIGTAQLLNREESWFTLPTGPIAPRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAC2</accession>
    <name>A0A401GAC2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0202940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610010.1">
        <property type="nucleotide sequence ID" value="XM_027754209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAC2"/>
    <dbReference type="STRING" id="139825.A0A401GAC2"/>
    <dbReference type="GeneID" id="38776014"/>
    <dbReference type="InParanoid" id="A0A401GAC2"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14266" checksum="D63D6451F3BB22CC" modified="2019-05-08" version="1">MFLCLPIFFGCPTRIKPEGNQTPRICPRCGNASVHSAKSRLWFELYFIPLIPLSSKRIWICSICQWSIPMEAGWEPGYDFQRGGVSNWQVPPPSGYINPPPNPYQQGYQPGYIDYAVNQGQKPEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB39</accession>
    <name>A0A401GB39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Lysophospholipid acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0205670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610282.1">
        <property type="nucleotide sequence ID" value="XM_027754481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB39"/>
    <dbReference type="FunCoup" id="A0A401GB39">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB39"/>
    <dbReference type="GeneID" id="38776286"/>
    <dbReference type="InParanoid" id="A0A401GB39"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="535" mass="60950" checksum="6723F8740561835F" modified="2019-05-08" version="1">MDIVFLPLATSLGVSIDQVKLIFCLLVSYPLGSVFIRIPTSKPTMKHLFNIAISLFYFLPVLNLWSGTLQLLVSVLGTYFLAAKIKRGRMPWIVFAFVMGHLTANHVIRTFRNQSYETFEITGPQMVLTMKLTTFAWNVWDSRRPVEELDQWQREKRVVQYPSLVEFLGYSLYFPSVLVGPYLEYADYVALIDGTIYKKPVVDKNRRLVPHGRKRVAYRKMVIGLALLGIYVTGISTFSYSATAQEWFKTKSFLYRFLFFQISGLFERTKYYAVWTLTEGAAILTGFGFSGYTSSGGTRWEGAANVNVWFIEFAPNMKVLLDNWNMKANIWLRECVYKRVTPKGKKPGFRSSMITFATSAFWHGISGGYYLTFFTGGFMQTAGRLCRAYLRPLFLPPTYVASRTAPPPPQTPLKRLYDLAGIVCTTLMLNYAGAPFMLLTMHDSLAGWSALQWYGHWMIGGALLFFYSGGRRLLKEAQVARVKKAGLYVEKNIADRTRDDSKAVPILPPVGDAVREMETEFERLMDDVMSPKEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC48</accession>
    <name>A0A401GC48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0209670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610679.1">
        <property type="nucleotide sequence ID" value="XM_027754878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC48"/>
    <dbReference type="STRING" id="139825.A0A401GC48"/>
    <dbReference type="GeneID" id="38776683"/>
    <dbReference type="InParanoid" id="A0A401GC48"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="487" mass="54849" checksum="610DFBE5CCAABB06" modified="2019-05-08" version="1">MSSDTKSPSVEKVEDLESVKVAQDDPDAEFGGTEQRKKMEKWLLLKLDLRMSILVIIYILNYIDRNNAGAARLRGFETDLHLKGQDFATLLSILYVGYIIMQVPSNMIMNYVGKPSLHIPICMAIWGMMSILTGITKNFVGALLTRFFLGFIEAAFFPGALFLLSKWYRRSELGSRTALLYCGNIISNAFGSLMASGILDGMQGKLGRAAWRWLFYIEGSLTIFFALLAIFILPDFPATTRGRWLSPLERRLAMRRMEEDAGVGDESETEAGGQMHGLWLAVTDWRVWWLAFMMTSQVVALSFNAYFPTLSATMGFGRTVTLLLCAPPFVLTAILAYIVSRHSDKTGERFYHMSIPYFFGLIGFVIAISTMNTAARYVSLFLMAQSYAGFVVLYTWVSNSFPRPPSKRAVAVALVNAFSQLGNVAGSYVWPSNWGPTYRYSYAICISTCCTAIIMGYIFKLHLTELNKQLEREEEEQGKERGFRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCH6</accession>
    <name>A0A401GCH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0210590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610770.1">
        <property type="nucleotide sequence ID" value="XM_027754969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCH6"/>
    <dbReference type="STRING" id="139825.A0A401GCH6"/>
    <dbReference type="GeneID" id="38776774"/>
    <dbReference type="InParanoid" id="A0A401GCH6"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24623" checksum="8C816989964D6D08" modified="2019-05-08" version="1">MSRSNSKPKGILKNAPPASGTGQHLQWDEENLALTEAQKDSQMKITEPKTPYVRYNAETDTLEGDIPALDLNGINGRVASPVSSLRGQSPSSSTGATGGGSTPSSRRTSFSSNGRTSTPVGRGSGSSSRSTSFNLPSEARDSIRLEDSQPGDEIEFEEEMDEETAAKHAAFVRARGRHYSNEAEAMKMAKKLMEEDDEESVVSVDHSVDDDSAMSVDEESPAKMNGIVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDA3</accession>
    <name>A0A401GDA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0213430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611053.1">
        <property type="nucleotide sequence ID" value="XM_027755252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDA3"/>
    <dbReference type="GeneID" id="38777057"/>
    <dbReference type="InParanoid" id="A0A401GDA3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="117" mass="13641" checksum="970A6B993C7C5C1B" modified="2019-05-08" version="1">MKLNTKDINHVAVRLCAAACDLRRSGSSKLDRLFISPQCFLDEMYVKKITRDFHLVDSRSVLASRLSGWQYWEDSGAALWDAVKKIADEMCELLRVRHEEMLGKQRANRQKKREEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDT8</accession>
    <name>A0A401GDT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0300540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611252.1">
        <property type="nucleotide sequence ID" value="XM_027755451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDT8"/>
    <dbReference type="STRING" id="139825.A0A401GDT8"/>
    <dbReference type="GeneID" id="38777256"/>
    <dbReference type="InParanoid" id="A0A401GDT8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18932" checksum="ED5DB1EFDB200AFC" modified="2019-05-08" version="1">MHELARQQMADQVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYVNPPPDVDDNEEEYEVEAILNHKTYRGHLRYLVKWKGYSSAENSWEPTHNLQNAKRILDAYKRTRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEC4</accession>
    <name>A0A401GEC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dicarboxylic amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0302470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611445.1">
        <property type="nucleotide sequence ID" value="XM_027755644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEC4"/>
    <dbReference type="FunCoup" id="A0A401GEC4">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEC4"/>
    <dbReference type="GeneID" id="38777449"/>
    <dbReference type="InParanoid" id="A0A401GEC4"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="42"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="540" mass="58873" checksum="823F94306AEC7A74" modified="2019-05-08" version="1">MADYDEKHSPDTTYKGVDTDSEAHAYAVPQEPGLHRAMKNRHIAMISIGGVIGTGLFLGTAGSLSNGGPVGLLLGYLIIGSLCYCTMVSLGEMAALLPIPGGHITYAARFVSSSWSFALGWQYWYNWVIILPAELSAAAVLINYWNKSVNNAVWITMCIVVVILINMFGPAVYGEAEFIFASIKVLTITGLIILGIVLDLGGGPNHDRLGFRYWKHPGPFNQYAGIEGAKGRFLAFWAVLTQAAFSYIGTEVVAIAGAESKNPRRNIPKAIKRVYVRILLFYIGGVTIIGLLVPYNNPHLNLASGTAAASPFVIAIQTAGIKGLPSVINACILTSAWSAANSDMYCSSRALYGLALAGNAPKIFTKVNRFGLPYYCVIVSALIACLSYMDVSSGSGRVFGWFANMTSVAGLMSWFAIAVTYIRFHKGLKAQGIDRNTLPYRSPLQPFAAWYAAILAFVVCFFSGWSVFLKGNWSAATFVTNYLPFMLYPVMVIGSGIWKREWLIKPQDMDFKSGLDEVLAASYDEPPPRNWVERIWAAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEF7</accession>
    <name>A0A401GEF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SCP_0302830</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611481.1">
        <property type="nucleotide sequence ID" value="XM_027755680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEF7"/>
    <dbReference type="FunCoup" id="A0A401GEF7">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEF7"/>
    <dbReference type="GeneID" id="38777485"/>
    <dbReference type="InParanoid" id="A0A401GEF7"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="24">
        <location>
            <begin position="327"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="68"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GBE80568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="693" mass="76682" checksum="177BDFAC5BFD3529" modified="2019-05-08" version="1">MPGPLTHHHHHQNSLSHTHYPSPPNANGLQGHAAMGQNGSPGSVQTPIMTPHWQQQLLKCDMIRVSRSPHHRARASAMASRTVQKAAIPITNPNAVKPPDTNGTSKKEQDGAGSSPSSASRPASESSPTPASGTANHPSSLVAPISEASRPTASKPPENTWNSLDMGGVNIKNIPPTSGLFSFTFLINLYLNHNALTRIPPEIAKLRHLELLDLSGNNLMTVPPELGMLTSLKELYLFDNHLANVPAELGTLHQLQTIGIEGNPSFDANLKHMVQRDGTPALISYLRDTCPSPPPPSDRVWKNLVSQAERDAMQADPNVETFSVLCYNVLCEKAATERMYGYTPSWALVWDYRKDRILSEVTGQNADFVCLQEVDNAQYEEYFLRNLSERGYEGVYWPKSRYKTMNDADRRLVDGCATFYKSSKYTLVEKHLIEFSAVAMQRSDFKKTDDMFNRVLGKDHIAVVCLMENKMSGTRLIVANAHIHWDPQYRDVKLVQVALLLEEVEKMANSFAKYPPRLPTPASVTSPVNGENNASSRPPPVYSDGSKIPLIVCGDFNSVPSSGVYDLLSTGSVPPTHPDFMSHLYGRYTSEGIKHRLGLKSAYATAGELPMTNFTPSFHGVIDYIWYSTANLSVNGVLGEIDRKYLEKVVGFPNVHFPSDHLCIVSEFRVRPLRDNPPPRPPPVFPESSRVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEP9</accession>
    <name>A0A401GEP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0303200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611518.1">
        <property type="nucleotide sequence ID" value="XM_027755717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEP9"/>
    <dbReference type="FunCoup" id="A0A401GEP9">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEP9"/>
    <dbReference type="GeneID" id="38777522"/>
    <dbReference type="InParanoid" id="A0A401GEP9"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="13">
        <location>
            <begin position="460"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE80605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="541" mass="59674" checksum="E3DFE34D7CFBB29B" modified="2019-05-08" version="1">MSASATLEYASHAPEPLPYPRLSGYHLLPSQTPDYLRLILTSKVYEILKETPLVFCTNLSARFGNQIYVKREDLQEVFSFKIRGAYNFMASLTEEERWKGVITCSAGNHAQGVALSGSRLGVPCTIVMPKGTPSIKVRNVSRLGAKVVLYGQDFDEAKAECARLAETHGLTFVPPYDDPLVIAGQGTIGMEILKQFPDADSLDAIFAAVGGGGLVAGVAEYVKRIGSPKTKVIGAETLDGDAMDRSLKKGQRVTLDEVGPFSDGTAVKIVGAEPFRICQQLLDGVVKVDTDELCAAIKDIFEETRSITEPAGALALAGLKRYIVDNDLTGAQKKFVAVISGANMNFDRLRFVAERAELGEGREALLSVEIPEKPGSFVQLHNVIHPRATTEFIYRYNNPERAQIYLSFKLESTSRAKEVSDLLAALERQGMKGFDISDDEMSKTHARYMIGGRQNVSNERVFRFEFPERPGALRKFLLGLQSDWNISLFHYRNHGADLGKVLAGIQVSKSDSQAFDTFLNNLGYPYVEETNNEVYKRYLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF26</accession>
    <name>A0A401GF26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611700.1">
        <property type="nucleotide sequence ID" value="XM_027755899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF26"/>
    <dbReference type="STRING" id="139825.A0A401GF26"/>
    <dbReference type="GeneID" id="38777704"/>
    <dbReference type="InParanoid" id="A0A401GF26"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13484" checksum="E01422ECB7DD4A44" modified="2019-05-08" version="1">MQRFKLVFFCPVPSTQGVLQHLFAKFPRHVGRIGLYGGCAFVSRGTGQFTPLAGANPAIGSVGTQEYVEENRVEVLVLPDSPAGPKQESRDSVQVTRVVEELKKVHPYEEVAYDVYRLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF43</accession>
    <name>A0A401GF43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0304420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611636.1">
        <property type="nucleotide sequence ID" value="XM_027755835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF43"/>
    <dbReference type="GeneID" id="38777640"/>
    <dbReference type="InParanoid" id="A0A401GF43"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="148" mass="16263" checksum="3ED05640D6D7780F" modified="2019-05-08" version="1">MATSDTGSSTAAPSEQDNPNTEAQLPPLVMQIVVRRDLLDSEDWGVGPLMAQAAHATAAVLHETKDRPETQAYLDNLTHMRKVVLQTADRSSIERLHTLLASCTPPVPHHLWVEQPEDVPTCLALAPNRRESTVRKALDKAGCRLWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFB7</accession>
    <name>A0A401GFB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611706.1">
        <property type="nucleotide sequence ID" value="XM_027755905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFB7"/>
    <dbReference type="GeneID" id="38777710"/>
    <dbReference type="InParanoid" id="A0A401GFB7"/>
    <dbReference type="OrthoDB" id="2754525at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="604" mass="66458" checksum="DCF706951A26A73E" modified="2019-05-08" version="1">MAGQLSHCSTLVLPPSPPLTLLTATFSTPDFECELQPSLVSAAELSSSEVSLCESQRSLEQILDIRADVTLPAEASKTGTLSSLLHCSDPFRAPLSVCTPLSDIQSIDNTMLRPPHIAFTVPVQQASLDMSRGRTMRRQSPTDSCPRSDSRTGPSRHAGKSSAVLGLSPGTLSPSCTTPDPPQSRYSHRLRRMAPPPLRFVSVTNHLAITLTQSPSPPPLVCAPDTFDDVPLKTSGACSPSAALPNAVSGIAEGMFPTPISLEQPSSAEYREGASHAHQPSRAQHVVIPGATLALGPSVFVYQEQPPIYSRNLPSSREPPSVLFNEQPHLRSMIDSVLDSPVTSNLVPPPLQRAAWAALPPVTYEDPVRVESSPLLSPLVLDIRQALAIDNFMVRADRCAEAVAQAALSLGSSSMLRDPEGITKICDTLQADLESIQKALDDTPEQLDVINDNAEHNWQHKHWQIVSSLDRNLDLFYLFANQIRQRPPRIHRLASHVDKLHAYHLKFTDLERRLTLSHEKFRLLALRSRYVQEHSSARALADMERAHRREFREAWQAGRVRRKEMRDEIRHVRGVTQYRSGRAIAAHEPAIHGESADDLHGCMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFC2</accession>
    <name>A0A401GFC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Carbohydrate esterase family 9 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0306060</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611799.1">
        <property type="nucleotide sequence ID" value="XM_027755998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFC2"/>
    <dbReference type="STRING" id="139825.A0A401GFC2"/>
    <dbReference type="GeneID" id="38777803"/>
    <dbReference type="InParanoid" id="A0A401GFC2"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="18">
        <location>
            <begin position="60"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="17">
        <location>
            <begin position="529"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="744"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE80886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="778" mass="85880" checksum="A8DD9430F11558C8" modified="2019-05-08" version="1">MSAPNGLICFTNCLLPHEDGSLEEKDLWIDERRGVILDAQRTFFLRKERPDRIIDLGGNILSPGFMDIQINGAYGFDFSVYEGDDDAYRQGMRTVAEKIVETGVTSLVPTIITQEKSLYPKILQLLRPFTASKCATLLGWHAEGPFIQLAKRGAHAPQFLMAASEELKSFEDVYGADNLADKEDWLMTGEGSSDSIGVRIITAAPEIAGVIPAMEEVVKRGVIFSIGHSTATTDVATEAVRSGARLITHLFNAMPQLHHRDPSIIGLLAASPHISYPGSAVERARNSPLQRTESLLKQVALSNALHEGPKAASEAFDDTETPPETPVVHNHTETDLHLVKGKVTDLAFERPFYELIVDGIHSHPNSVRLAHSTFPEGCILITDAMKILDPHLKDGVHEWRDGKRFVKEGDKLYLEGTDTLAGSVVTLDKCVRNFSRFTGSSLGEAIKCVTYNPAKCLGLENKKGTLRPGADADLVVLDRKGNVLSTWVKAADMATDSPSPFTDPPNYQFPTHRLHRVLRNPDKQPIVLVACGSFSPVTYLHLRMFEMAMDYIRQNTDYEIVGGYLSPVSDMYKKPGLLSAYHRVNMCTLAAEQTSSWLMVDPWEAFQSYQRTAVVLDHFDYEINTKQGGVTTADGVHKPVSVMLLAGSDLIATMSEPGVWSDADLDHILGRYGVFIIERAGSDMDQAIDSLSRWRHNIHLIHQLIQNDVSSTKVRLFLRRGLSVRYLLPIPVVDYIEQHGLYTDDGSSAAEREKEKGKEREAGSSDKGNVALASSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFC3</accession>
    <name>A0A401GFC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611783.1">
        <property type="nucleotide sequence ID" value="XM_027755982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFC3"/>
    <dbReference type="STRING" id="139825.A0A401GFC3"/>
    <dbReference type="GeneID" id="38777787"/>
    <dbReference type="InParanoid" id="A0A401GFC3"/>
    <dbReference type="OrthoDB" id="5570013at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="15002" checksum="4EAEFC3B6CDC5FE4" modified="2019-05-08" version="1">MLAEIGRAITASVRMSSPDSTGGAFKVSTQTSNGPVHVHFVDSPVDTYLDFSARTSNAPAGASLHRAYEGSFSLHTTHKAPVLHISEHAEDPSGRARGRNVTSSRWRSGLEGSVAWGNPPYDQPLGSASVQSTNSAVTLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFM7</accession>
    <name>A0A401GFM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="4">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NIP1</name>
        <name evidence="8" type="ORF">SCP_0306920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFM7"/>
    <dbReference type="FunCoup" id="A0A401GFM7">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFM7"/>
    <dbReference type="InParanoid" id="A0A401GFM7"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000300">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058999">
        <property type="entry name" value="EIF3CL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26569">
        <property type="entry name" value="EIF3CL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="612"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="821"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="156"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="822"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="877" mass="99497" checksum="6DA193865505DECC" modified="2019-05-08" version="1">MSRFFRQAGDSDSESESSEEELMSSDDEGAPKPASAKPTMSRLLRTGDDSSSEEEEDEEEEESELSEEEAKEEKRKSRFLRTESDEDESDEDVKRVVKSARDKRLDEMEACGKVMDNALKINDWVAISNEFDKLVRMVQRQQNVSEPVPPFYIRTLTNLESSLNSAVAKEKEAKKKMNASNARALTAMKQKVKKITKEYEKELKQFQADPEAFEKEYAALLVHEVTAAPKPKKVKKLLAGASDEEQEQPDDDFTTVGKGGKAMLFTSDSIFKNLQLIQDARGKKNTDRSDQMRILEKLLEVAVTSYQRIRVLLTLISSRFDYNSSVSTHMPIDLWISAQREVDQLISIIVLNPAYSVQEVTEDYDEQAERSPATEKDGVVRIRGSIISFVDRLDDEFTKSLQNIDPHGTEYVDRLKDEKGLYCTICRAQALYEKNKQEEPQGRVVMRRLEHIYSKPDAVVHALESAVATMDNKPSIVLSVEGQSSMLIHSLCVHLYKSGNSFLRTRAMLSHIYHYALHNDFHTARDMLLMSHLQESVYSADVATQILYNRTVVQLGLSAFRCGLIKEAQATLQDIFATQRVKELLAQGVHQQRYQVLTPEQEKAERQRQLPFHMHINTELLEAAFLVSSMLVEIPLLASIDSEEQKRKAISKSFRRLLDFADRQIFTGPPESTRDHIMQASKALQNGEWEKCRDLIQSIKIWSLMPEAASVKEMLAKRIQEEGLRTYLFTYAPYYSTLSLSLLSRTFSLPLRTVTSVVSKMIWNEELSASLDQAVGVVVFHRIELSRTQQLAQVLADKVNNMMEQNEKTLDLKLGNTTSWGDRVDGAKGDKRGEQTQERRGRGERTRGGVRGGARGGRGARFAQGLGNQMAGTQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG96</accession>
    <name>A0A401GG96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0309330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612119.1">
        <property type="nucleotide sequence ID" value="XM_027756318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG96"/>
    <dbReference type="STRING" id="139825.A0A401GG96"/>
    <dbReference type="GeneID" id="38778123"/>
    <dbReference type="InParanoid" id="A0A401GG96"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117084" checksum="6202FB8E71348286" modified="2019-05-08" version="1">MSAVGAPDAMKTFMLRSSTPASSEKVLLYLEGMQKAPPDEEDRASVRSSGRMRSPLSKASASTNGRRLEELAEEDAGYEEHRNGGIEIRSDVQEANGSDIARTIPIHTTGLPEHEPGPDDPPGPHFESYGSSFGNFGPLPPGPAPWNNGQTNAPLSPIDTASFTSSHPNPFQQFGMTPATAAGVPLPASVASPSVHTRPISTKAQSVADAGANGANGANGIRSPKAQSRVLSPARTGGERPWSPRSVASHGQSLKSRNTQKTQRTVYPPLPESMMEETASQRPPSPQRSIAPSESASQMTKSRYRAPTTKEPSQKARSVRSTTEVNAIPQQGTAAEYYAEVRSQRDGRSQAPMSQGPMSQVAMSQGPISQAAMSPRSYTSQVPPLRTAATNEELQRAAAAALSPTRSKRSNHDPEATPTPSRPTSPVMDLDADEQRMVHDLLSRPSRSRTSFALSTMAPSALEPEIQNSHFHDMELCQLLHALDQPMGEPVKKAVRKAVRTRVKKLGMKYDNESIKQYRKSYHDHDPSVHLNAALNAIAPSSRRSTQLGASQEPPEWAKDLIDGMINMRERLDILAPKIEKSLRSSRGDSYVAESRGYLNGHHHHHYSHSEMNGGYTQSPMTQTVNIHTQPSGTMGDDSMFQPGETELLRESTNLHTLPGSMHHHDGSVRGAIPEEDMYEDEDDLHLHDGDPRGMGSRSDYMPTRAESPGQQYLEEELYKLRVKPTGSQSGATHKTWEVARDDGEDYDDEDVQAAVTESGMPEIPDTNTGVYTDRRASPPLPPIPHDSRADIVMPEPQVWQPGDYSTEPPLPPPWQRVHQRLLSWAIVWPMAELDNALNSTTRGMQVDEVALSIWSTQTYKRYVRAKMTDTPRGRVDRLFVPPNMADAISTAVYNGRHGDACGMLRDLWAPFGLEGIPRLLVVLAKHRNDENHWVVHRFSLPDGSLTTYDTFPERCLPDGRPLGWWFAIRIAWPDAIYPSPDHLMQKMVRLHRPLQLPIDNSVAAAGIWRNLLMGSRAERSLDLERLRDLMNTEVKNLRQRKVMGKLSIGSPKPNWEDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGC7</accession>
    <name>A0A401GGC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho guanine nucleotide exchange factor scd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0309490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612135.1">
        <property type="nucleotide sequence ID" value="XM_027756334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGC7"/>
    <dbReference type="FunCoup" id="A0A401GGC7">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGC7"/>
    <dbReference type="GeneID" id="38778139"/>
    <dbReference type="InParanoid" id="A0A401GGC7"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="209"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="875"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="958" mass="106037" checksum="1EBA9F125AD8222F" modified="2019-05-08" version="1">MTSTAAGRKKSMISTTPTIESPVANNTLLNKAASQSTSLYQQCSALRTRLMRVQDFPEWFTLSSPPESSRRSTDPVTQLWDCFALGVPLCYLFNLLPAPFTTINIDTGSTSFDATNEKTKKRAIALFSMQIKQIEGCEQFTVTELWDRNSTDGFVKVVNNVIHLAQHLPEDVFVESAPPSPTVLSEYQSTDSLTMDGGFSTPPAEPNGARFNIIKELVETERKYVQDLESMQKYSNAASQNNVIDQDTIHLLFPNLNKLLNFQRKFLIKLESVAELSWDEQRWGLPFIENEDEFAVYEPYCANYIMASEILLQEEQNLAALNHVLDAKVELPAFLIKPVQRICKYPLLLESLLKAVKSTDYPFCHELESGVAAAKRITDKINEAQRRAENHATVKNLEGRVEDWKGHHISNFGTLLLDDIFTVTKSEVDREYHVFLFEKIILCCKECLSPPTNGKKVNKSNSILKKPVVPAPLVLPGAGPSRKRNTPLLLKGRIFLNNVTQAVPKVSAGQYSLAVWWRGDDDLEFFTLRCRNEEQLKMWENQLNRMIQETASRRTSDRNIRLQMTSASAPVIRQPSTTHSQERTYSVFSQSTAYSSAPAVHSAMSSPYLSGLQSNRSSRHPYAIDEYVQASIPPDQLGYSDGPQGYPPHDGFDVDPDDDFEDYPPSSAFPPSGRGTPIGTRRLEYNGYPLTSRMSGHSTITPTSATSNHGSPFGSGRPSISRTGGSYTPDSNGYGSGPPPGRSSTLRSQFSSTKLRSAYEQSPNGGPALPSGTSPMRSRSASQPSAYVPNTLPPPLPTSVPWSNRSQSSMGVNKRGSGSSQSTGDSSDYSPHSSSSPITPFGSSESSLGNMSLHPIRSQRSDQVVTSAMDQLGAPVKVKVHFHEDIFVIQVPRSAEYTELVEKVGKKIRLCGPRRDDGPLRVKYKDEDGDLVSLGSTEDVQMAFESFRPGNQVTLYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGQ1</accession>
    <name>A0A401GGQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0310690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612255.1">
        <property type="nucleotide sequence ID" value="XM_027756454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGQ1"/>
    <dbReference type="STRING" id="139825.A0A401GGQ1"/>
    <dbReference type="GeneID" id="38778259"/>
    <dbReference type="InParanoid" id="A0A401GGQ1"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="29"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="238" mass="25747" checksum="C15962C2D70B84C8" modified="2019-05-08" version="1">MQQCPFAKRAFTIEYRISDPGPDSNAIPNSFPAGLMDVVAGYVYLVDVVGFEPENIIVVGDSAGGNLALAFARYLVDHIAELSATVKTLGPLPPSYPLVLLSPWCDLGTSHESPASSLVTNTYDFLPDVRRGLLFEVRKVYAGLLGMEGASVNPYLSPASTHSAMDGPSFKGFPPTFISAGGMERFVDQCRTLAKKMAADLGEDRVVYVEEPDACHDVLVLPFEQRNDTMKALALWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGQ8</accession>
    <name>A0A401GGQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HbrB-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612272.1">
        <property type="nucleotide sequence ID" value="XM_027756471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGQ8"/>
    <dbReference type="STRING" id="139825.A0A401GGQ8"/>
    <dbReference type="GeneID" id="38778276"/>
    <dbReference type="InParanoid" id="A0A401GGQ8"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="59756" checksum="0C44874E5D9B9C76" modified="2019-05-08" version="1">MMENSFMSTARFRRSSQDSSVLMQAHAERRRSSSQSDATPRQGGLLQGGGGNSTPAGTAPSSDAVPPSADTPPKRLAFLPELLLSAASGSSALIQRSSPIPSQFLPVRSHSRAESTLGTIPREPSPSPTPMTATSGAQVKGHISPTKASSSRTYDSKLVSREMHRLGNLAHLPSLAPALSAAQSTVSLGMAPSAGSSMSSGSSGENPWASLHVHILPLFNGEPLRVPLEDLNQLVKRHVQIVVSASPSKALTTLEHDTSELLASGMVTLNAKLSGIEDEKLVARIVELWGFFWDQILPYVEGALLPLQTDPLLLSLYRMPKAHKANSPVTSQNGKGSISSLMLQSTPQIDVRTVALQSFRDRIILPLFPRLYARLTLPKEEAENPVLQQPRLQQMLLVLVSQHPQRAPTFSLTAPPPPPSAGEAAVQHLLRAVRAPLPHLQRASAGTGAPSFVADGLPRDRRGRIAQKYDYPADVDEEGGETPRIGGVGGVAFTSPRREKEFFDSLRSPDVDTWDESIHRGEEEGGIEEDAEKDSGQQHNIMNRLAGMSRRREAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHV8</accession>
    <name>A0A401GHV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0400660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612608.1">
        <property type="nucleotide sequence ID" value="XM_027756807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHV8"/>
    <dbReference type="FunCoup" id="A0A401GHV8">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHV8"/>
    <dbReference type="GeneID" id="38778612"/>
    <dbReference type="InParanoid" id="A0A401GHV8"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="41"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="484" mass="53691" checksum="09287EBF141BA615" modified="2019-05-08" version="1">MSRRSLSAARRTEAIRLHLMSTSSAPVEEAPVLFKSDGALRAYILNRPKKLNALDETMLSILRPKIEEWARSDLTGVVAGTAVGRAFCAGGDVARIVEYSKKVETLPKAVDFFHREFEMDYILAAMPKPYIAFMDGITMGGGVGLSVNAPFRIATENTVFAMPETKIGYCPDVGASYFLSRIDGEIGTYLSLTGETISGRAVFEHGFATHFIPSRRIPGLLERLAGFEDPTYAQIDILLEECRSDQQPGQLNSLLVGNTRIALDKAFRHNSVEEIVGDLRAFAEGSENEEVAEWAKHTLAALDLRSPTSLKVALAAVRKGKTMSLLEALQMEMNIASAFCHGVSPDFRTGVTAVLVEKLKGRPDWLPSKLEDVNDEFVEKEFFNAFTPEDGTSPRITPPDYLVDHTRLMDPMRFALPTEEEIGQLVAGNHKTSGGFALDLEDLLEKFNDIKKGKAGVREKVLEVVDRRCTFEKDSDKQWLEWKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GII0</accession>
    <name>A0A401GII0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase sol3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0402950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612834.1">
        <property type="nucleotide sequence ID" value="XM_027757033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GII0"/>
    <dbReference type="STRING" id="139825.A0A401GII0"/>
    <dbReference type="GeneID" id="38778838"/>
    <dbReference type="InParanoid" id="A0A401GII0"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="343" mass="37591" checksum="8D7B965BAF165972" modified="2019-05-08" version="1">MKLSFFGVMRAQLKPKAPVVTTDLSGKTVIVIGANVGVGFEAAKHFAEMNPARLILACRNEAKGNAAITKIEEATGYKKSELWLLDLSRFSSVLEFVDKFEKDGGRLDILLANAGITGSKYETTSDGWESTLQVNDLATFLLCILLLPRLVHTAREFSTTPRLVVVASDIHYFASVDKAALDSPKVFETLNTPESYSSMNAVMNRYAVSKLFDVFFVRALNAHLPPSTPVLVTAVNPGLCATELGQKEPEGFIASCVRYVIFRTFAHTAEEGSRELVWACVGGQEREDDLRGAFVWHQQITEVSDYVLSPEGAALQERLWNELLEILGGVSPKVPAIVGEYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GII1</accession>
    <name>A0A401GII1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0403550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612892.1">
        <property type="nucleotide sequence ID" value="XM_027757091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GII1"/>
    <dbReference type="GeneID" id="38778896"/>
    <dbReference type="InParanoid" id="A0A401GII1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="208" mass="22176" checksum="D1348E01AD7862AC" modified="2019-05-08" version="1">MDSLLKKAFTAEDARANADEDDTEGTALNSGLSVHIPILAAVFSFFAGSAFNAAVRDTPLAMRCGQFDSLIPLGSERHLIAVVSLLTVVSLLTVVSPLTIVSLLPVISLSAAFSRPTALHIANCLHNATMHLRRLRTVSSQHVPGRATLPAKCGADCQRTTAFAVLETLHTIGKMPRQGWEEEAYRPQAGDAKAGREHDALSPALLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJN7</accession>
    <name>A0A401GJN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4,5-DOPA dioxygenase extradiol-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0407580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613287.1">
        <property type="nucleotide sequence ID" value="XM_027757486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJN7"/>
    <dbReference type="FunCoup" id="A0A401GJN7">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJN7"/>
    <dbReference type="GeneID" id="38779291"/>
    <dbReference type="InParanoid" id="A0A401GJN7"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="66"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="321" mass="35021" checksum="8F83AB421F629D2F" modified="2019-05-08" version="1">MSSTDSTQPAFPRSRTEWRKALDELPSTPDNIPSFFFGHGSPFLVFPESDVQGDSPVSRQMGPKGPLATFLRDFGPALLAKYKPKGIAVFSAHWETVGERVVTDYGDLNPVLMDYYGFQPALYQLQFRSRGDSALSKRIVELYKEAGHLARTTTKLEARGEDGRGFSGPGLDHGVFVPFKLMFGEVFMDVPVVQISIDGSLSPEKNWAIGTVVEQLRHEGILVLSGGLLVHNLRNMGSFAEESASTAVKQFDHAILDAVTIVDPGLRHKEMINLTQHPGFRAAHPRAEHFIPLYVAAGAGGEGKVKVVSAIYGSSTFAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJR3</accession>
    <name>A0A401GJR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0407900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613319.1">
        <property type="nucleotide sequence ID" value="XM_027757518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJR3"/>
    <dbReference type="STRING" id="139825.A0A401GJR3"/>
    <dbReference type="GeneID" id="38779323"/>
    <dbReference type="InParanoid" id="A0A401GJR3"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29904" checksum="8E75A3AF5787DDBD" modified="2019-05-08" version="1">MTTARLPQTVFFATAVTSLHFLHSLFSDVLPHIFRTTFSRSSRLADTMLSSSKLLMAVWGVFDFCLLGSGVLMLALSIVWREPNLMINIALSTMHLNAALILAILFIVTFVISIGAMVQKNPGILGFVVLNWALIVDAIATLVVGTIIWFYSLQERNNYYAVWKMQTNTTRVAVQNEFSCCGYFLPNDTAAIGGFCVSDTFVNSLPTTSACVSHITAFADDMLQPIFTYIYFFMGIVLCLLLASLCVIKTRTEVERFRKIDAKRGGGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKR9</accession>
    <name>A0A401GKR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0411500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613678.1">
        <property type="nucleotide sequence ID" value="XM_027757877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKR9"/>
    <dbReference type="FunCoup" id="A0A401GKR9">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKR9"/>
    <dbReference type="GeneID" id="38779682"/>
    <dbReference type="InParanoid" id="A0A401GKR9"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="277" mass="31277" checksum="51572AF0C29F5319" modified="2019-05-08" version="1">MSVNPNEDTEFNDILRKHGILPPREPEKRAPSPPPPPTTREKIEGLTAKELKQFGENAGDDETERMVETLRRQRLSELRRYQKAPYGRVYPIGRDDYTREVTEASKVNDDGSPEGEGNGTGVVCFLYKDGILRSDSAVQHVRILAQRHPHTKFVSIVGDKCIANLPDARIPMFIIYRNGDVLNQIVAWGGDRERKIEELEAVLILGGAITPEQQQGLRSERSRDSNSDDDEPDDEDSGDSLSDRMRSAATMTNVHSGKNIRRTQREEDSDSEFEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL11</accession>
    <name>A0A401GL11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0412450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613771.1">
        <property type="nucleotide sequence ID" value="XM_027757970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL11"/>
    <dbReference type="STRING" id="139825.A0A401GL11"/>
    <dbReference type="GeneID" id="38779775"/>
    <dbReference type="InParanoid" id="A0A401GL11"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30604" checksum="4DC822EF3E330EDA" modified="2019-05-08" version="1">MRILLESVTPVVLKSAKTPRIQLSDSALDIEHLFTMLYDSQRYFSLSSGPVEFSMVLSLIRLGHKYEMTTLRDGALERLKTCFPADFEEWCELDEDGSAYVTMKPEDAIAAVNLAHLTQTDSVLPSALYGCCSLDTHTLLHGMLRTDGSSEKLSQEDLERCVEGRVKPMWRVKLMEANTRELRWVLKLDQASPACSQKWHCTVKLRELPAKAHREAHGSFYALTQWNAVFQLGVCDKCADMVTAAELEGRRKVWSKLPSLMGVTVEGWGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL47</accession>
    <name>A0A401GL47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0412880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613814.1">
        <property type="nucleotide sequence ID" value="XM_027758013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL47"/>
    <dbReference type="GeneID" id="38779818"/>
    <dbReference type="InParanoid" id="A0A401GL47"/>
    <dbReference type="OrthoDB" id="3170088at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="193" mass="22598" checksum="9BFDAACB49C414D2" modified="2019-05-08" version="1">MVLRIGGWVLTYDQVRTWLEVGGRDSKNLEFYELSGALKDWFRERQIEDMVPIPTDYPHGTKQPVIILATRYYQDPAATVTHYTLFAERDFEREVKRRVLEETGFKDDDLRWVTVIDPYFQYPVVVYKKPRNYALWPETGRPPKKDKTKKKADGDEKGEEEDKEGGDKKEEGDKEDGDKNEQGDKESELTQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM49</accession>
    <name>A0A401GM49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">SCP_0503230</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614188.1">
        <property type="nucleotide sequence ID" value="XM_027758387.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GM49"/>
    <dbReference type="GeneID" id="38780192"/>
    <dbReference type="InParanoid" id="A0A401GM49"/>
    <dbReference type="OrthoDB" id="3261476at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="466"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="735"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="841"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="742"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="851"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GBE83275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1332" mass="148990" checksum="767EC484DFC6CD4F" modified="2019-05-08" version="1">MSLYPPVPQVKPKAESNRLYDVLFLESNGSNFQMWKYRMTTIFRLCGLYALIDGTETDLGAADSTKKADWDFRNSEALAQITLTLKDEPLNGVMYSMTVQDAWEKLNKHYEGRGKQTLAYLISDLFRSTLSNESPLEPQLNTMQQKAHILETLGLALDDTLIAIAMTISLPPSYSTLRTILMASDSKLTVEKVVNEVLSEEKRRGEMTAASALIVKHANFKAKLKGKDKDRKKKGKCAFCGFPGHTKDECRKFKASQAEGTAAKGDKKAEKAAETKESAKIASVSQVDSETLCLFIAEELAHGDDLLHRWIVNSGASSHMTFHREWFINYRTLAMPKRVYLGDEHFILAVGIGQVTLHAAVDHGSMNTGIVQEVLHVPDLNGNLLSVSQFDHNSYDVRFTDGTCRISNAQGQLNAIGHISVGSVLKMVQKRMVKGMSIIGEKVSEAICKPCLHGKQTRQQILKESDVKNPRVLHRTYSDVCGPMQTQTRSGHCYFITFIDGHTHKLVANLMKMKDEALSQLKAFIERAEVKTGQHANILQTDGGGEYESKEFDAYLKAKGIHHEKTNAYTPQENGVSERMNRTVEEMARCMLNDARLPNAYWGDAILHAVNILNSIPTRVLPDGLTPYEAHTGNKLSVAHLRIFGCKVYVHIPKEKHQKLDSKMLECTHLGFTENCKAYRLVHRPTGRIIESRDVYFDEGSEVEPSHVTIDVTPAQPAPDVRPLLQLQPLLALHPPRPTVEDVPDEDEDAPALLNIDDDSDDEDDDEDDDEDDEDDDAPLPEPHYQHRQQAPRAAQSPPPVSVPAAALVPELRRSGRTCTAPVVADDDRYFVSSYTRKLKDQDNAGGVGAAAGPAEGAAGVGDENAENVRKAANWDELQTYEEAMSRPDAARWKAACTEELHAFVKAELYDEVERPRNRKVVDCKWVFKIKRGPDGEIEKYKARLVAKGFTQVEGLDFNETFAPVAKFTSIRTLLALTAKLDLEIHQMDVKSAFLNGDLDEEIYMNIPPSFRKDNKLIWRLNKALYGLKQAGHKWYKKICAEFEALGFTRCNSDHSVFYKNDNGTLLIIAIYIDDMLILSDNPTAVNTLKDDLNTPMAQNQKLIKLSEAEIDPKPYQSALGSLMYAMLGTRPDLAFAVGALSQHAAKPSKEHWNALMWVYRYLRGTAEKRLVYQTTTREKELLLGYVDADWAADVNDRRSVTGFVFHISEGAVSWSSKKQSPTVQSTEYMAGAHGTKEAIWLHAFLSEIGQVLKGPTSLLIDNQSAIVLTKNAAFHDRTKHIAMRYHFIREKYDSGEIQPEYVPTGNQVADILTKALPREKLKKFKAEMGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM74</accession>
    <name>A0A401GM74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0503440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614209.1">
        <property type="nucleotide sequence ID" value="XM_027758408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM74"/>
    <dbReference type="GeneID" id="38780213"/>
    <dbReference type="InParanoid" id="A0A401GM74"/>
    <dbReference type="OrthoDB" id="3224257at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="656" mass="71649" checksum="9C85261C74C2D90F" modified="2019-05-08" version="1">MLIFLIPGAPRPNVFFTVSLADPCEYVPLSPGWAAQLHALQADELDMPSSVHALDKATWLLAILTEVTFDLTTLTISCAFTDGPPIEWPLDDPACVRMLEDVLADVVLATGELEREREKELQTEREREQQTEPANKAELVPAAKPVKHKKQRSLLMSLVSSLNKLTQSVCADSSAPSGLRRTSLLTAPAPPPGRPPRVSLPLHRPPISAFLPPSRKVPLPRVPPPAPSILYQHRARSALVEVFRASIVPALRARMVPRAYRAWAAQNMLQRVEGQMTAIVQDAGGVPALGGELDLMRGALPGTGRGARRVSSSPFFDDEFDDASLTDSVSTDTDGSSVHTPVDSHSSSPFDHPEKLAAGHGPAQQLPRTPSPPVFSREDLAEYTALSAQCLRLRQVLARAEAAQLDAQHDERAFLAVLEVKSRRRAWSNRAYLGGAHYSGIGLATPFRSSPLARYEPVMPARLAEVGRTRERRQRELDVCTGEINVATLFPVCEEEEEDDMLVGGQKGGYQYGQLLGPPAITRSGEEGSLARPPIRSRTLSMHSLDLDLVLVPDSPRLQAASLPLPLAPPPALRSPPPSMNVNVNVKPMRPAMLEPRTKFALFEQVDHPERVLVDDAVEFTLAMDLPAPPPYSRVQVQTHGNVLPHVKEWDAAQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMD4</accession>
    <name>A0A401GMD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614278.1">
        <property type="nucleotide sequence ID" value="XM_027758477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMD4"/>
    <dbReference type="GeneID" id="38780282"/>
    <dbReference type="InParanoid" id="A0A401GMD4"/>
    <dbReference type="OrthoDB" id="2799963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="246" mass="26172" checksum="7608A3D52387453E" modified="2019-05-08" version="1">MSSHGGWRQTAHGGDAAQGGRGRTDSAEAPRNSSPLGFVATTGLAIVDVPASPPSSASVSSLAESDPEDAAARALLPQPLPVQHGVPLFVRERIGGAMAMTESRDPRLIQMSMGFPISVHPIRIPNTRGMWSSASSTSVVDVNFVRLAGILHRMLPLRLVDDVQLSGVFGGNMKVYGRVDVSFDAYGFEFNVPCWVTDLGFPVEILLGSDWMVNNGVESTWSGGGPIITGANAKRVRNIQDVYITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMS9</accession>
    <name>A0A401GMS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0505680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614429.1">
        <property type="nucleotide sequence ID" value="XM_027758628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMS9"/>
    <dbReference type="FunCoup" id="A0A401GMS9">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMS9"/>
    <dbReference type="GeneID" id="38780433"/>
    <dbReference type="InParanoid" id="A0A401GMS9"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="447" mass="49914" checksum="713255680FEC64A2" modified="2019-05-08" version="1">MASTLVKSQRSLSQAKGQKVPGSSVGAPAQRNQSSRKGKRAWRKNVDLEEVEEGLEEARAEERVAGGIVKDKTNDQLFLIDVKGDERVRKSLPRFSTSLLTSAKILAQRSAFPAVFSRTTTTVAAGVKRKLTHEEKGRLLRMGKRVRRGPFNAMIDPTEFGSGSAMLEVSEAARKSGGYDVWDEELAEGTKVKHPNTPHPRSHITLSAVPTPHEGTSYNPLVTSHQELLRTAHEIEERRLKDAEALEAAKAKVLGGLVEAGADAEDVAPGMTVDEHAEEHSDQDGSEAEPRLPAKMPRRKTKQERRKAERRLAEQRALTEKAAKKRMLTSIDSAKALRKAMGRKLATRQRLREQRQAALREKLAKGLGGQKLGKHKVPEGNVDVQLGEDLTESLRALKPEGNLFRDRFLSMQHRALIEPRVPVLPKKRKIKVKEYEKHAFKRFDREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMT7</accession>
    <name>A0A401GMT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0505790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614438.1">
        <property type="nucleotide sequence ID" value="XM_027758637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMT7"/>
    <dbReference type="FunCoup" id="A0A401GMT7">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMT7"/>
    <dbReference type="GeneID" id="38780442"/>
    <dbReference type="InParanoid" id="A0A401GMT7"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="320" mass="36918" checksum="7E66E38DBBB7B081" modified="2019-05-08" version="1">MPYSHHSHSGQFCKHAAGTLEDVVLEAIKQGFEVYGLTEHVPRWRLKDLYPEEEGTSIKELAVQFDQFIAEAHRLKQLYADRITLLVGLETEFITKVDLDNLEKLLQRYRANIEYVVGSVHHIQEVPIDFSRETYEEAIAKFGGELDPSPSVPFIQMEVFLGEYFDGQYKIMERFRPEVIGHIDLCRLYNPTLKLEPYHLAWSKLQRNIRFAVSYGALFECNAAALRKVWDTCYPGEDVARLIMKEGGRFCLSDDSHGPHAVGLNYGRMANYLRRIGVSELWVLERSETANAGGRFVCPRKVEGQWWEHSFWQQTGVSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMX5</accession>
    <name>A0A401GMX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspyridones efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0506420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614500.1">
        <property type="nucleotide sequence ID" value="XM_027758699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMX5"/>
    <dbReference type="GeneID" id="38780504"/>
    <dbReference type="InParanoid" id="A0A401GMX5"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="45"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="442" mass="47759" checksum="8E081B29A3D3DDA3" modified="2019-05-08" version="1">MDSQTVAGPPSESEKKSDELSLRTVVVTPTNTELDFPEGGWEAWTVVFGGFMAFIASFGVMNTYGVFQDYYSSTLLTKSSSSTISLIGAIQIYLLYGAGPIVGRIYDAYGTSVIIPVGSFLTVFSLMMVSLAQENQPYQLFLSQGILFGIGIAAIFNPAMAVVGHWFRRRRAYAMGIVASGSSVGGVFFPIMLQRLIPTIGFPWAVRAMAFVCLFCLVVACFTIRTRLPGSRRITLRGLIDFDGFRDKKYVFAAAGAFLIFYALFIPYFYIEIYADMQGVPHNLAIYLLPIINATGIPSRIIPGILADRFGCLNVLVPSSIITSIFVLALWLPARNSGEIIAFAALYGLFTGGVVSLLPAYIYKISPLEKYGARLGSLYMVVGIATLVGTPTAGAFVHVVNNKHFNGLIIFCGVFIAVGGAILGLTGAFTKEERASAHVGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN78</accession>
    <name>A0A401GN78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0506850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614543.1">
        <property type="nucleotide sequence ID" value="XM_027758742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN78"/>
    <dbReference type="STRING" id="139825.A0A401GN78"/>
    <dbReference type="GeneID" id="38780547"/>
    <dbReference type="InParanoid" id="A0A401GN78"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="345" mass="38931" checksum="CABB66A2085F2A82" modified="2019-05-08" version="1">MKKVILVIGATGAQGLAVIDKLLEPSADGLPSPYTIRALTRDPQSKRSLELAQKGVEIVKGSFYDFPTVKTALEGAYGAWVNTDGFTVGEAKEIFAGIRIFELAKQSKTMRHYVWSSLDYSLKKGGYDQKYRCEHYDGKARVAEWMKAQPSVVSDDAMSWTVVTTPTFGPLNRRVDGTFVFATPVGTGHVPMIALPDLGFFARYTFDNRALTSTAELEVASDMVDWEYLLATFKKVTGQQAVVVYLNYDQWLTYLTNSNAPLANEQKVLEEGQTSWGENFSAWWSLFRDDVIKRDMQWIRNLNPNTKTLEAWMREKGYKGEYAYLLKNTEEGKGISLNRERTSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNT2</accession>
    <name>A0A401GNT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Folic acid synthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0504520</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614317.1">
        <property type="nucleotide sequence ID" value="XM_027758516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNT2"/>
    <dbReference type="FunCoup" id="A0A401GNT2">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNT2"/>
    <dbReference type="GeneID" id="38780321"/>
    <dbReference type="InParanoid" id="A0A401GNT2"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="16">
        <location>
            <begin position="477"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE83404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="798" mass="86926" checksum="78AC6F5D7BAF916B" modified="2019-05-08" version="1">MAHDLHQAAENDDLSHSIDYSSVLSSLASSCAAPSSSLEVLSERICDTCFTSYPELGELYVSISRPKALLHARATRIVSEWRRSHHDPVHEKFFIEELDCQAIVGVNPCEREEKQRVRFNIMLDRHKRRAQFDFHEVARKVFENVQSSSHLTLEALASLTARTVLLHTGTISDRVTVRAAKPSALVLAEAAEVEITRTLRDYEPSSASTLKQTHENNVTHAPASPTPSLFSLLAALPERSGHDETVYAHRAAIALGANLGDRFANIELALRLLEMPDGTGRPRAAVVDTSFLYETAPMYVTDQPQFINGACMIETDMNPRSLLAFLKDIEATVGRVSSFRNGPRAIDLDILTFDAMTVDTRPESKKDKLDNLTGELVVPHPRIAEREFVLRPLSDMIPDYVHPVLGKPVRTLLLELVAKQSTDTPAMSKVVPFPRYPYISPSIATVTPGIPSVPPTATYWTFPVYSSTSSRRPLQKSYVMGTLNATPDSFSDGSRHNTTPAAVAYATASVAGGADIIDVGGYSTRPGAAYVSPDEEISRVIPVVEAIRGLSSEQNTVSADARLSARTADVPISVDTFRWEVADAAVRAGASCINDVYAFTGPAYPLDMSAAEYFLKFREIARELAVPVVLMHSRGDAASNKDYSAYSYAADSRGRGAVLEGVRVELGEKVEAAVRGRGGLRRWLVIVDPGVGFSKTLEGNLEVLRASSEITAAHPHRRNPLAGFPQLIGTSRKSFLGTILAQPDTGGAYEGRKTRPDERGWATAAAVSCAVQQGAEVIRVHDVLEMGDAIRVAQALWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP13</accession>
    <name>A0A401GP13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L31-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0505450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614407.1">
        <property type="nucleotide sequence ID" value="XM_027758606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP13"/>
    <dbReference type="FunCoup" id="A0A401GP13">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GP13"/>
    <dbReference type="GeneID" id="38780411"/>
    <dbReference type="InParanoid" id="A0A401GP13"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="126" mass="14412" checksum="E0A7C825AED24B19" modified="2019-05-08" version="1">MAPTKTTAKKTGKTRSALQDVVTREYTIHLHKRVHGRSFKKRAPWAVKSVVDFAQKAMGTTDVRLDPKLNQALWARGIKSVPHRIRVKLERKRNDEENAKEKLYTYASHVIVESFKGLETLTVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP27</accession>
    <name>A0A401GP27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0510320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614886.1">
        <property type="nucleotide sequence ID" value="XM_027759085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP27"/>
    <dbReference type="GeneID" id="38780890"/>
    <dbReference type="InParanoid" id="A0A401GP27"/>
    <dbReference type="OrthoDB" id="2755869at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="26240" checksum="779B41F7B38AC55D" modified="2019-05-08" version="1">MSSSASLSSSSAVVSTSSTPSSGNSGGGFFSANGTPALILAFLAIGLFVGGMVTMFALRRRRMFRLGNRFLGRRTNTWTSDIPESTVPQRTERRRQRHFGKKPELWDVYTVKEEYQDASWEKVTPISAKVITEELPDVLHDVDPPPLFSPPHESRFHSLISHGRFGFLRSTEVQPTAAPTRPPRIEVAVAIAMPVPSSSDSGMLEYSLGLAELPWDSDMHAAMHSAEQGPALDNREQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP28</accession>
    <name>A0A401GP28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0510360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614890.1">
        <property type="nucleotide sequence ID" value="XM_027759089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP28"/>
    <dbReference type="STRING" id="139825.A0A401GP28"/>
    <dbReference type="GeneID" id="38780894"/>
    <dbReference type="InParanoid" id="A0A401GP28"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="520"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="614" mass="69175" checksum="F70EF40DCDE67DD2" modified="2019-05-08" version="1">MRANATLTPCPNGNHLWCIGGEFFSDDGKAHFYNDVFRYSPEKDEWRKFVSPTCPGPRSAHAVVGSPAGGGKLFLFGGEFSSLYQNTFHHYRDFWCFDITTHTWERIDTKVRPSARSGHRMAMWKNYVVLFGGFYDPGLRTNYLNDLWLFDAQEYKWRQVEFRDAERKPSPRSGFSFLSTADGILLHGGYCKEYSKGKRPIGVMLDDTWFLRMTLATETEGKAPAEPLSMKWERRKRPSAAFAPSLRSGCTMALWSTKNTGILFGGVTDEDTSEETLDSVFHNDLFGYQIAGNGRWISMMLKKTKKKGVGGPKKQKPAAVPARPIEERYEPADFEFEEHSEEDDKRKASTEQANATVDITPGPEMDPDDPNLTTPLPRYNAMLAVLRNTLYIYGGIFERGSREYTLDDFYALQLDKLDCYTCLKPSGILISAEGDDESSDDDEDDEDDENDEGEDDEEDEAEAETEEQRKGTETLQSPEGDRITVIEEAEALEIGAAEKDALRSQATAFMGVAKDTKRSAEDIISTPLPGEILAMFYARSREYWAQKAHESSDNRGKMLRRDGFVLAGERYAVYKPVLTEVEKILAEAGLDEEEMKRGAAAGPSGPSEQSRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPE8</accession>
    <name>A0A401GPE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0506890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614547.1">
        <property type="nucleotide sequence ID" value="XM_027758746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPE8"/>
    <dbReference type="STRING" id="139825.A0A401GPE8"/>
    <dbReference type="GeneID" id="38780551"/>
    <dbReference type="InParanoid" id="A0A401GPE8"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="200"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="102"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1206"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1216" mass="133492" checksum="3883A8CFC06FC976" modified="2019-05-08" version="1">MTYSANAGSYSMRHGFSNDSYQKQQQQHYAAAAHYLPSHPPIKLEDSPELPPLHASRQHTFSQYDDRHHHKPAPLPVFRFGSDFASNVSSPNPASTFSFMSQPWSGSPNSPVSASASSYGHQQQQYSMDRSHGYGLPPLNGHGHASTMALNDDYDDAEGDDLGDLPGSSLGLGVSSYSPGSGPASSAKNEKAIRRRSSKACDQCRKSKCKCERSGPHEPCRNCVMLGTACTFLGPSRKRGPPKGYIDAIEARLHQTEALIGILLGSKDSRARTVLEDLSTEDPLAKEIIDRVDNSPYGHKGRSRGAEATGSSRSRPAPSEGRDGDSTVQSTHPSNEWQDKVIARLNTVASTRNTLLAAEDAAELASSGDLRYPEDDTVADARARPLLALSQPGSGGNTAGPSTATSDQSSAEQAVRRQRRRVGDEPARSPSTASLSGRSRSPGGVASRPYGVRSASALQTRESISSLVEAAQGRSPEARDDEDYEEAVDGEEASGEDELAIEIGQLSLNEDEQVRFHGKASGLHLLGMGMKEGLDGRNEGGIWRFPKARVWPPLPPNTRTRSKVLEDFSPRLPDAATQELLLELYFTYVHPALPIVHKRAFMEDFRNGNTMSADSPYSDQASDAASPISASSLCIPRRRRTPTLLLLAMFSIAARYSARTGAEVPPPQEGSMWTAGDSYLEDAKVILDASYAASRPSTCQALLLMGYREIAIGAMAQAWLYVGMAVRMAQDLGLHKSADRWTSTGRNLFTTTQLQERRRIWYGCVIMDKYVSAYIGRPVAICERDFDTELPSTAETDELELWSPHPSPPLDDGADDPAVADFAPSPGHIISCFTESAKLSVILSVIMQEIYAIRPRCDRQTEFSKYEKLLTKWYLELPEPLRFEPASAKPSTPPPHILTLHMQYWCTVLLLRRPFIRHLSDSRSTSTSSKDCEIRASSRKNYDLCVQAANHITSIVSVYAERFNPKRASAFMCYYVFTAAIMHVAALTTYPSDPQARVGLDKCMDVLKRMQILWPSAFRALELLHGAKPSSPEPEISRSRLSDRPKRAAEQSLDHEDTNDGARLLTSDQLYRQQQSYHNVAPSSPPASQQGFIGLNLPPGDSSAYMPQYDRWAGETTLPSFAGSLTTSVLPQQYSTGLVGERLPPSITRSTERQGQRYPQYWSDYSALGQMDTTYGVPVIGEMVPQHANAPQPDQPSMYVPDPQYMFSNIPPNSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPF2</accession>
    <name>A0A401GPF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614942.1">
        <property type="nucleotide sequence ID" value="XM_027759141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPF2"/>
    <dbReference type="STRING" id="139825.A0A401GPF2"/>
    <dbReference type="GeneID" id="38780946"/>
    <dbReference type="InParanoid" id="A0A401GPF2"/>
    <dbReference type="OrthoDB" id="2560085at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="175" mass="18166" checksum="9CA75B17842D8341" modified="2019-05-08" version="1">MSAPLQVARLVSLALATAFGIIGMSVGVDALVQSDRQKNTVRQSAPAGVSVSIDTSDVFASGVVNTVVCALLAVVSSSALTTALVSAPARRASRLCAHVLLLLSVWLFAALVPFTDSVAHRQANVSATLDGAALPPSVIQAVQAQSGATGTYHAISYREWPPQPLHRPFTAYTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPR4</accession>
    <name>A0A401GPR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615063.1">
        <property type="nucleotide sequence ID" value="XM_027759262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPR4"/>
    <dbReference type="STRING" id="139825.A0A401GPR4"/>
    <dbReference type="GeneID" id="38781067"/>
    <dbReference type="InParanoid" id="A0A401GPR4"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="277" mass="30511" checksum="0F45F22AB4467A60" modified="2019-05-08" version="1">MSATEANYPFNKPTADLTVCSSDNVNFGVHRIILAEASPVFETTFQLPQPLDAQNHHVVSLTEESGTLDKLFRICYPVPDPPLDCLEDVEAVLAAAAKYDMDEAQAVCKKALLDADLVQRDPVGVYAIASQPEAGRCDACGRSTNAPLSIRAAGFPVPHFGETPRDSYCYNYDCFRCRDEDGLEHEPVPAGWVTRRYSLDVDVKDYLSYAAELMEVSPCGDALVEDAELGSCRFVESSLPACKDCRRDICTLMRDWRNSLAEDVKGAIAQQQLQIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ11</accession>
    <name>A0A401GQ11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615234.1">
        <property type="nucleotide sequence ID" value="XM_027759433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ11"/>
    <dbReference type="GeneID" id="38781238"/>
    <dbReference type="InParanoid" id="A0A401GQ11"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="196" mass="21719" checksum="389723A69678F028" modified="2019-05-08" version="1">MNASVILHKYTLAEALLRIEIFTEPFDSILWKAWAVRMHVLLVLMVQAQSEAASVGIILPLPHDIPVLAQVEIHLATARTVECGRRMIPQIADHLPAVIPHGLTARVLYDDPAVREDFGLGHPLDGLPDIGTLHLRVKTLRNAARELYDVMCGITGRRELADGTLRRLRITVEELEVAFGLVACPPPITSFQLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQH8</accession>
    <name>A0A401GQH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0510630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE84004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614917.1">
        <property type="nucleotide sequence ID" value="XM_027759116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQH8"/>
    <dbReference type="STRING" id="139825.A0A401GQH8"/>
    <dbReference type="GeneID" id="38780921"/>
    <dbReference type="InParanoid" id="A0A401GQH8"/>
    <dbReference type="OrthoDB" id="3067798at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="252" mass="27699" checksum="766D86634585928A" modified="2019-05-08" version="1">MQEEQLRPRFPRRNHLPALNGPVGLAAKKAHDLGRTHIAATSTIEEIRDLTIAAISAPPDSLLMSTSSVLGTGNDWVSDEYVLADLTVPHVVWHATILSTSSSAPSSPIPMLINCGLPSVLIREDIIEHFQLHRIKLSQPFPLGNTWGSGREDAHEWAKLHITSPDFSWSSISCQAIIVPSLCAPVILCNPFLKFNHLVLDISAGSLMDKCTQCNILIDVPRPPLSPPPTSPAERRREAKEMHHIQAQFFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GST3</accession>
    <name>A0A401GST3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0704620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616188.1">
        <property type="nucleotide sequence ID" value="XM_027760387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GST3"/>
    <dbReference type="STRING" id="139825.A0A401GST3"/>
    <dbReference type="GeneID" id="38782192"/>
    <dbReference type="InParanoid" id="A0A401GST3"/>
    <dbReference type="OrthoDB" id="3249498at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10701" checksum="8FF92D02DFAD72BC" modified="2019-05-08" version="1">MSVEPISRIAVYSNNTNMVALFNMLRALPAYNDITKSAMDVLLQDDAQLCVVHIPGKENVMADALSRKRFELVMELIPKIQLSPFTPPRDALGAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTS4</accession>
    <name>A0A401GTS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 52E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0801240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616519.1">
        <property type="nucleotide sequence ID" value="XM_027760718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTS4"/>
    <dbReference type="STRING" id="139825.A0A401GTS4"/>
    <dbReference type="GeneID" id="38782523"/>
    <dbReference type="InParanoid" id="A0A401GTS4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE85606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="587" mass="66447" checksum="61DC57EA6E3BF47D" modified="2019-05-08" version="1">MRYNYRLRLFRDLVRIAAVPSVSLYIIANVADIHFGLLAFPAYLAFAAVWAYAVALYTDLAQDREAGRLGARQIPRVVGKWPGNIDVLLQLLEASPKSYISMFQLALFEKYQSTTINLRLLWQDWIISMDSEHQKYVLTTGFNHFHKGVGPKERMEKFLGDGIFNRDDDLWKAHRAIARPFFARDRISDFGLFERYTSATLSLIFSITSSGQPVEVQDIFARFTLDASSEFLFGTNMDTLSGKLPIPGKTKMSPMGSATDDEFGGFSSAFETLQAIVSKRIKRGKLLWPIAELLHDSMTPHVKVIHEYVDPLVQRALENRRSMEKAGVQSSPEQSTFLEYLAGNTEDPSVIRDQLLNILIAARDTTAQLLTYIVYFLATQPEIAKKLRTEVLGHCGADGPPTVEAIKAMKYMRAVIHETLRLFPPVPANARESRSTACLLPKADGTYPSMPDSLYMPPETSFTYYPILMQRNPALWGPDADIFDPERWLDERAARYTSNPMIYVPFSAGPRICIGQNYAYNEASCFLTRMLQQFDSFTLAPEVQPEGSLPLPEWKSGKGRQTFEKLWPSNTLTLYVKGGLWVHFHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVG6</accession>
    <name>A0A401GVG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617105.1">
        <property type="nucleotide sequence ID" value="XM_027761304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVG6"/>
    <dbReference type="STRING" id="139825.A0A401GVG6"/>
    <dbReference type="GeneID" id="38783109"/>
    <dbReference type="InParanoid" id="A0A401GVG6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="116" mass="13104" checksum="82041BAE86D04A20" modified="2019-05-08" version="1">MPILYAAEDTVEKWLNSLLCLNVTVMPRSSAHSCPHPAHSRRTSLLSGARVVRIATHPDYVNFLCQAPKHLKCPQIYLSDGREIPSAVLAVAADYRNPFSQIRHHIYCVWTSCSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVK8</accession>
    <name>A0A401GVK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0901340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617168.1">
        <property type="nucleotide sequence ID" value="XM_027761367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVK8"/>
    <dbReference type="STRING" id="139825.A0A401GVK8"/>
    <dbReference type="GeneID" id="38783172"/>
    <dbReference type="InParanoid" id="A0A401GVK8"/>
    <dbReference type="OrthoDB" id="3270165at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="193" mass="22057" checksum="95C55AD1A5CD0229" modified="2019-05-08" version="1">MIAEGKPFKGFILDFDYSSFWMDVQAKKNLVPAIVGAVLEARKRYGDRLFEEGDSARMKMLSVGDNVMRELKERAGTPAFMAIEFLGRHTPIVHEVHHDLESFYWLLIWLVLRHTNDDHHHGSSAVFRGDENLCRTHKIVFLLFETLTVRGNAPLTHLLKSLAALVMKSICWANLKTDIVRLTHAAFLQALNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVL4</accession>
    <name>A0A401GVL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617159.1">
        <property type="nucleotide sequence ID" value="XM_027761358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVL4"/>
    <dbReference type="GeneID" id="38783163"/>
    <dbReference type="InParanoid" id="A0A401GVL4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17125" checksum="74476B481DD2C3EC" modified="2019-05-08" version="1">MSLPISTSERMNSWPVDPSPMFSRFSPLFVTHPTSHEANVMGAMPQYTDVDTSDEVSDNAGLDDEETLVFLAEEETDTSTIPRGCPSLPRLKPIELPDVSCDIQYEYPKLAPLDMCLVALLEPTSHNDANSASSDYSDILYPPIVKSHLPELHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW34</accession>
    <name>A0A401GW34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0804980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616887.1">
        <property type="nucleotide sequence ID" value="XM_027761086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW34"/>
    <dbReference type="GeneID" id="38782891"/>
    <dbReference type="InParanoid" id="A0A401GW34"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="15854" checksum="E285D535AB7C890F" modified="2019-05-08" version="1">MGTKTSDTSSDTPLMEYPHPLLARRQNQFPFDLALLVHTHPVDDLRYPNHLSRPHPLLRVAVIPTGMDVSPNKDHEQAGGHATDVEEIIMSATAPDDDEDHNISYGTRNVRRELMLQRSSLVARLFFFFSLFPLRYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWB1</accession>
    <name>A0A401GWB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0903510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617385.1">
        <property type="nucleotide sequence ID" value="XM_027761584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWB1"/>
    <dbReference type="GeneID" id="38783389"/>
    <dbReference type="InParanoid" id="A0A401GWB1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="56" mass="6419" checksum="AB1B8F42AEA68A0D" modified="2019-05-08" version="1">MSIWDMDQYHQKSATIDTHIDGQIEDINSQIKDIQNPAQEHDVSVSPTQQREPSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWM4</accession>
    <name>A0A401GWM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0905060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617540.1">
        <property type="nucleotide sequence ID" value="XM_027761739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWM4"/>
    <dbReference type="FunCoup" id="A0A401GWM4">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWM4"/>
    <dbReference type="GeneID" id="38783544"/>
    <dbReference type="InParanoid" id="A0A401GWM4"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="92"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="569" mass="61421" checksum="EE681E283018715F" modified="2019-05-08" version="1">MLSVPSSEPWAAVQPSWSQYHPRDEKLSRAQSRSWLASFAPSVHTLPLSEKHPWESSDPSLIRCVSRWARHRLPSFELPVLPPLPSPSAVRFVLLCALWYTTSALSSNTGKIILTQFRYPITLTFIQFGFVAAYCLLFMSPLVHFSTFRPPSRAIFQSTIPMGFFQVGGHIFSSMAISRIPVSTVHTIKALSPLFTVAAYALLFRVRYSPKTYLSLLPLTLGVMLACSFDMTAGNAMGLLCAFGSSLVFVTSNIFFKKIMPSNGGSTAHKLDKLNLLFYSSSMAFLLMVPIWAYYDLPLLLAAAADPAHVSHPPHDGGAHSAHFHTLAQHVLANGTVHFAQNIIAFVLLAQTSPVTYSIASLVKRVAVILTALVWFAQPVHPVQGLGIALTFAGLCLYNRAKGDVAQGETRMRRVNAARDMALPTTLRDPILDPDMRLPPTVVVDAPPPAEPALAFASAYTRPGAHAHIHPTAAAAAHPFPPSALPAPVPATPPPSYSQTHPHPNLHVKIAQPSGTPPVGSYPSPPPSLDSPPPQHPAWPAARRGSMVTGHPPPHAMLEASAPRAAIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWN3</accession>
    <name>A0A401GWN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0904890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617523.1">
        <property type="nucleotide sequence ID" value="XM_027761722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWN3"/>
    <dbReference type="FunCoup" id="A0A401GWN3">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWN3"/>
    <dbReference type="GeneID" id="38783527"/>
    <dbReference type="InParanoid" id="A0A401GWN3"/>
    <dbReference type="OrthoDB" id="10254258at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="13">
        <location>
            <begin position="58"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE86610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="211" mass="24280" checksum="8C958E822DD56852" modified="2019-05-08" version="1">MIGENPQGRAETTNASRVFPPLYVSTGDVSIDRLAFFHILERLKTQKRTGWVDHKVPAPESISDHMYRMAMLAMCTSDARLDSSKCVMMCLVHDLAEAQVGDIAPREGMPKAEKRRLEAEAMHNFVHDMLHNSAAAQRIEALWKEYEDGESDEARFVKDLDRFEMASQASEYERKHSMQLQPFLDTSLPFVQHPEVTRWGQDLIAERERMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWV6</accession>
    <name>A0A401GWV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SCP_0905500</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617583.1">
        <property type="nucleotide sequence ID" value="XM_027761782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWV6"/>
    <dbReference type="FunCoup" id="A0A401GWV6">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWV6"/>
    <dbReference type="GeneID" id="38783587"/>
    <dbReference type="InParanoid" id="A0A401GWV6"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="582"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="441"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GBE86670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="789" mass="87286" checksum="6AE2EEB28E523720" modified="2019-05-08" version="1">MAVAYSLPSDLSPATVTNTSSLLRIIALALISGAAIASRLFAVINFESIIHEFDPWFNYRATKVLAAKGFYEFWNWFDPTAWYPLGRVVGGTIYPGLMATSGVIYNILHALNLPVDIRNICVLLAPGFSAFTAWSTYMFTKELKDESAGLLAAAFIGIVPGYISRSVAGSYDNEAIAIFLLMITFFFWIKALKTGSAFFGTLAALFYFYMVAAWGGYAFITNMIPLHSFALICMGRFSNRLYVAYSSWYAIGTLASMQVPFVGFQPVRTSEHMAALGVFGFLQIVAFAELVRSHVSSKQFQSLLFASVIAMGVLGVAAIGGLTYKGWIAPWTGRFYSLWDTTYAKKYIPIIASVSEHQPTAWPAFFMDLQFLIFVFPAGVVLCFRELRDEHVFVIIYAVVASYFAGVMVRLMLTLTPVVCVASAIAISSLLDTYIDPTEPEVLEENEGRAEPTQAQTATNAASTAVSPKSGSSTGAKKAKKSSPVPPADPISDIMSTVSAAVNPSKKDAKARGIFGLDTRLVVVFNALGMLFFFVLHCTWVTANAYSSPSVVLASQNPDGSQHIIDDFREAYYWLRQNTPEDAVVMSWWDYGYQIAGMADRPTLVDNNTWNNTHIATVGKAMSSSEEVAYPILRKHDVEYVLIIFGGLLGYSGDDINKFLWMVRIAQGVWPDEIQEPNYFTAKGEYKVDEGASPAMKNSLMYKMSYYRFPELFGGNQAVDRVRGQQIPKTGPTLDYLDEAFTSENWIVRIYQVKKEDLLGRDLKSANAFAQGKKRKRARPPTRRKAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWX7</accession>
    <name>A0A401GWX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0906170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617649.1">
        <property type="nucleotide sequence ID" value="XM_027761848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWX7"/>
    <dbReference type="STRING" id="139825.A0A401GWX7"/>
    <dbReference type="GeneID" id="38783653"/>
    <dbReference type="InParanoid" id="A0A401GWX7"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="139"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="347" mass="38835" checksum="E6CDC50B7ACDCBA6" modified="2019-05-08" version="1">MSRLNVPTVTVTYACFIHTQYSHSPINKFTVTHRGTAHRLSFLPDTTLAVLQAHLEELTSVPPAHQKLLYKGKNARAADDATILDAGLRYGVKVQLLGSTVQEIGGLRAAEDEHQRRERILRERAAKGPTRLRSTGPSVPSMGAQYRFHSIEPLAHLPDPAAARALLSRLASDPAILHVMQNHQFSVPLLTELAPHEHPDKLGINISPMHIIKLRLRTDTYDGFRAYREIRKVLCHELAHIVHKNHEVGFKELNSQLSREIVDFERAAAEGTHSLGDEAYTSSSYLEAEAQAYLASEGPHILGGSSEYPGDESRERRRRRVLQAAIIRLRKEEEELERQCGTTEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWZ0</accession>
    <name>A0A401GWZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0906290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617661.1">
        <property type="nucleotide sequence ID" value="XM_027761860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWZ0"/>
    <dbReference type="GeneID" id="38783665"/>
    <dbReference type="InParanoid" id="A0A401GWZ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7529" checksum="A3DD1377A6196681" modified="2019-05-08" version="1">MFSPAQASGYSDIRIPLAQAVLEYERRYGRKPPREYKNDKIFWRGTSTGGGSSPAALPHSISGIGSSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXX8</accession>
    <name>A0A401GXX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial 2-oxodicarboxylate carrier 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1003230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617989.1">
        <property type="nucleotide sequence ID" value="XM_027762188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXX8"/>
    <dbReference type="FunCoup" id="A0A401GXX8">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="GeneID" id="38783993"/>
    <dbReference type="InParanoid" id="A0A401GXX8"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="104"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="197"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE87076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="297" mass="32303" checksum="0B77975A1BA6C82F" modified="2019-05-08" version="1">MAVSERKPLPFIANFTAGAIAGISEILIFYPLDVVKTRMQLETGKAKHGLLGSFQSIIKEEGFGKLYRGLVPPLLLEAPKRATKFASNEFWGKTYMQLAGAANMTQQLSILTGCSAGATESFVVVPFELVKIKLQDKTSPYAGPMDVVKQIVRKDGLLGLYAGMEATFWRHVWWNGGYFGSIFQVRSLLPKPETKQARLANDLVAGTVGGFIGTAINTPFDVVKSRIQGATKAPGVVPKYNWTYPALVTIFREEGASALYKGFVPKVLRLAPGGGVLLLVVEFTLGLFRQALGPPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY66</accession>
    <name>A0A401GY66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lid2 complex component snt2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0906250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617657.1">
        <property type="nucleotide sequence ID" value="XM_027761856.1"/>
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    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048189">
        <property type="term" value="C:Lid2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:chromatin binding"/>
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    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="zf-HC5HC2H_2"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00249">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BAH" evidence="7">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="183"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="665"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="238"/>
            <end position="247"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="565"/>
            <end position="576"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <begin position="863"/>
            <end position="874"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="934" mass="105516" checksum="3EE7EE9211F2D4CD" modified="2019-05-08" version="1">MPPSASTFYLPLRNGDQVKVNDHVYCSPSFAVRDGTPYSVARIMEFLPAQGTPTFDKGGKRNEPFTRVRVAWYYRPSDVSDRPVADSRLLLAAIYSEVCDINQLRAKCHVIHRDKITDLAGWKKRPDRFYFQRLFDPWIRKEFEVISATTVRNLPANIRDVLISRYEYVVAEKEVVPDLTDTLRHCDTCEQWCSPPETVQCDRCKKFFHMGCVNPPLLAKPSRGYGWTCAPCSRKHEEEVDSHEVRHPTPIAPKPKTNAPAPRGRGRPRKDRTLAEKEENMEIKHFKMWPFRYFGLYTVAEDTLDPDDLIFPRTATRVGPKYQSSVPLAPGLERSPELEERGGDSTIEVLGLVQDMSPAEVDTFELCKNTLTKDKTLKANVDWLTEVTFRFTDAWLAKRDLTTVNMKSPMRLEKWKKSETRYTDKDWNVLEIAAFEDAMLIHGAELRPVRDQVGTRPMPEVVRFYAHWKNSKLGEENIRIRAARSGGRDDAVRFTSPALSIDEGSIVRELTRGNNSCGACRTRESDVWWKAPKGLPTNILCDNCGISWRKYADLNVRPVREEALAKAKSGDKREGTPLHGPASKRAKTTPSVTSTPPPSGPVPATTQLRCLACQKQGPAGKVLRCRQCQFRVHAGVCGVVVDQSTVESWICELCSNEKTLEASLIPDCILCPRVRRDPKKKLLYPPPDSFLRACKPTEGQTWVHVVCTVFIPEVMYSDARRLRLVEGVSTIPQYRWSNKCTLCDHDGGAVVKCAECPAEFHVSCAWRHGHKFGFELQPVKASRRDSTTIVEFKDHSGCMVPLIICKGHIGHRRELHEICETNEFGETALQIYCQNYKQVPTAHTHGLLRKARRLDNILGGSDGTSTPSSDADTPPSGPEFRCYRCRSEFSPFFHPVSPANGKAVAHPDAKSWMCHRCFVEARENQVVTNGTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYK3</accession>
    <name>A0A401GYK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1004860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027762351.1"/>
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    <dbReference type="Proteomes" id="UP000287166">
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
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            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="279"/>
            <end position="301"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1"/>
            <end position="17"/>
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            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114803" checksum="3A2DACF78031B569" modified="2019-05-08" version="1">MSSNAEAEPTWPSTSGSLGKGNDKPDNPGIPAASGAVEAQPSSTLIDKDKEHCCKICKAEKNGRKLIVALDGTLNQFGRKNSNVVEIYARIEKDGQQLSYYNSGIGTYANTARSTIWKRTKLKLSSLFDMAFARNFEKIVLGAYRWLSDTYQPGDQIFLFGFSRGAYQVRVLAGMIEQVGLIYSGNEEQIPFAYQLYEQADDSMANHFKETFSHREVKVHFLGVWDTVSSVGVFGRKKDLPRTRSCDHVCHVRHALALDERRVKFNPEFFEPSTKDALRGHLSSSVGQSRNLQTDRMNSSERDGVYTHLKEVWFAGCHSDVGGGNRPKDKLLMEDIPALWMANEARTAGLKFKPTKVGWNMEQLKHETPIESLTPSWWILELLPFLRHSESLPHLAQSEDLPWWSYARLIHWLHRVAPHCGEHRYIRPDQKIHASVTLTIGYTPRARFIFSRDATCTWDRILGKDHINELSHFEKRIEFDLYDISSAVSLVQALEYTNEPELQSALDRLLALAEFEAGVAAIIWADRGHRTLKSLIKRELTDEVKAKAVELVFRIGIQRSNDPQSQQYRPQLNLLLLWRAGFKDVLMPLALAESDKLSQVKRTILLLYLPDPLWVDHPYDSSILKFAIDCLSTDAADIAIATLLTLHKVNPHLVEQEVWKFVGDTPAESTVNSFNSGIVSILEKLPAYMRVSALQLMEHARGSSLYGHVNILNSTEIANALINLINLSQKDILYSAARLFPQFVALCKNPGVKPGGKGYHWWCTLSRWQLGGGHNRTVFSNGVQFLKGLAKHSGQDTVTDFTNFVLSPDAVLSRQSIDSFKQTAGIQGLRELICWVKQYGTAESFTPHYLTWLQKAFQGEADLLHRSTLHAISQTAMSKSPGCKIVTDNASVAGAFAEYLNSNDQQTKTWAIKELRNFEAPLVKNYHHNVQSLAHRKAGGSFEKEVLDCGIINLLLKLIRNGEQLVIHLPVLSLMISNAKLRHRMVEHKIIEEVAQHVRHGGGIKIIALEFLADLAQYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ86</accession>
    <name>A0A401GZ86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618399.1">
        <property type="nucleotide sequence ID" value="XM_027762598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ86"/>
    <dbReference type="GeneID" id="38784403"/>
    <dbReference type="InParanoid" id="A0A401GZ86"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="264" mass="29921" checksum="79F62E7340A1461E" modified="2019-05-08" version="1">MRIQILSDIHLEMERPGSAPGQEFYHYDIPVCAEHLALLGDIGWTVDERLFEWLRAQLRLFKTIYYVAGNHEPYRSSIDESNQRLSAFAQECEADPTLGDFIFLNRTRHDVSPTLTILGCTLWSALNPGDLDILSWSLTDFRRITSFDPEKYVALHTAELAWLSATVAAIALDEPERAIVVFTHHAPTIEGTGDPKYIGQPTNSAFATELSGEDVWTRECVKLWAFGHTHWSCDFERADIRVYSNQRGYAQGGSHYDPSKVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZC9</accession>
    <name>A0A401GZC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1101760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618412.1">
        <property type="nucleotide sequence ID" value="XM_027762611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZC9"/>
    <dbReference type="STRING" id="139825.A0A401GZC9"/>
    <dbReference type="GeneID" id="38784416"/>
    <dbReference type="InParanoid" id="A0A401GZC9"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="322"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="407" mass="46513" checksum="D4E9B3747B036BE6" modified="2019-05-08" version="1">MASRISFIPMTNTPYYVIAPYDDVPLSYLLNETAIMTAPSIQTVHTSTVDQLLQQQESSLAKSPFYLGNPTLSNHVDWFCKDPSNDQLIVKQRTPDDPPQLADLTCIGEIGSDHYYMFPGGYNTANDKLPQGNTEFERVRGYFRLHPPRKKIVRDLWKPMLDGLKKLQSTVPNARGPIRYSIVEEGVMLKIRHDWFEFQYVVQSDEEQSDNNDSLSPSDKVSECSSTTHLTADETDSESRKSVTELDTEFGIVGALRRLEQDPSDRFIGHIGRQPLLDIVFDEYPNSGPFPTVPAFHDYFSNLPFEFNASMPHPFRSKLIDDVPIVFTHSDLHPSNVIVSAEGDGAPRVVAIIDWHQSGWYPSYWEYCKARLTAEVGSEWETGYLWRILQPTEQWEDWNYFCLKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZD2</accession>
    <name>A0A401GZD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1102000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618436.1">
        <property type="nucleotide sequence ID" value="XM_027762635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZD2"/>
    <dbReference type="STRING" id="139825.A0A401GZD2"/>
    <dbReference type="GeneID" id="38784440"/>
    <dbReference type="InParanoid" id="A0A401GZD2"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="12668" checksum="1A532EF04F7BE919" modified="2019-05-08" version="1">MDFNLLYPTIIQEYNIDFMIVDRMEDEEGEEKIPESLSPEVAQGILPRPIATLVNRRRQAKSLMKDRKATQSQLLQWDIKQMALKLTANSTCGCLGFEYSRFYALPSLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZJ0</accession>
    <name>A0A401GZJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1102390</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618475.1">
        <property type="nucleotide sequence ID" value="XM_027762674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZJ0"/>
    <dbReference type="STRING" id="139825.A0A401GZJ0"/>
    <dbReference type="GeneID" id="38784479"/>
    <dbReference type="InParanoid" id="A0A401GZJ0"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE87562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="559" mass="63935" checksum="CDDA6E586F2CDDA7" modified="2019-05-08" version="1">MHKPSARLIPFGVGAGVVLWAIYCFVSWTDHPWHPSSHPSGYNFNPFRRRTTWLERADAVRGAFLHAYKGYREFAANNDELLPLTDGAVNNFNGWRLTLVDGLDTMWIMGFRDEFYHSMPIFAELSFALEPDSYAPFFETVIRYLGGLLSAYALSGEPVLLERADELGSMLLPAFNTTSGLPTYAVNTVSGKTRMGWMRGAVLWSEALSCQLEYKFLAHLTGRRVYYDRVEKIMNIMEKANVTDGVFATRWSLLNGKPLNSHFSVGAFADSAHEYLLKQWLLTSKSEPRARDLYIRAATSIIEHLLYITPNRNLLYVTDMQDFKPTHTFEHLSCFLPGLLALGAQTLELPARTQLLHEWAARGLAYTCWITYADHATGLGPDEMIMDAFPVSEEHPRGGHWLDHVERWEASGRPGGVPPGLAETRPRRQSRDYTTRKPAYYLRPETVESFYILWRTTGDRRWRERGWAVFEAIEREAKTPSGYASLSSVEDSPAPKKNEMPSFFMAETLKYLYLLFTDEELIPLDRWVFNTEAHPLPIFEWTDSEKAMYNITHGYGTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZJ7</accession>
    <name>A0A401GZJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">54S ribosomal protein L16, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1102570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618493.1">
        <property type="nucleotide sequence ID" value="XM_027762692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZJ7"/>
    <dbReference type="FunCoup" id="A0A401GZJ7">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZJ7"/>
    <dbReference type="GeneID" id="38784497"/>
    <dbReference type="InParanoid" id="A0A401GZJ7"/>
    <dbReference type="OrthoDB" id="268521at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_uL16_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_uL16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220:SF13">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="175" mass="19288" checksum="C78ED703FBD71C69" modified="2019-05-08" version="1">MPPPRQVKYIKRHKGVIPIPTGGSTKGTTLAYGDWGIRIKGCGKRLTAKQLTSAEEVLKRKIKTIKGAKVYMRVFPDIPVCIKGNETRMGKGKGHFEFWATRVAPGRVLFELGGAPIREEIAREALRLACDKLPTQNEFITRATPPRLGNMLIMPEGPLAAVERISQQAKTPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZU5</accession>
    <name>A0A401GZU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1103730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618609.1">
        <property type="nucleotide sequence ID" value="XM_027762808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZU5"/>
    <dbReference type="GeneID" id="38784613"/>
    <dbReference type="InParanoid" id="A0A401GZU5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="15681" checksum="C78DE9630AF3B5A7" modified="2019-05-08" version="1">MGIILPLPRDIPVLAQVEIHLATARTVEGGRRMIPQIADHLPAVIPHSLTARVLYDDPAVRENFGLGHPPDGLPDIGTLHLRVETLHNTARELYDVMRGITGRRELVDGTLRRLRITVEELEVAFGLVACPSPITSFQLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H010</accession>
    <name>A0A401H010_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">10 kDa heat shock protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1104300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618666.1">
        <property type="nucleotide sequence ID" value="XM_027762865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H010"/>
    <dbReference type="FunCoup" id="A0A401H010">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H010"/>
    <dbReference type="GeneID" id="38784670"/>
    <dbReference type="InParanoid" id="A0A401H010"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="11432" checksum="6BC8FA2F1D9D5FB1" modified="2019-05-08" version="1">MAAQATFKSIKAVVPLLDRVLVQRFKQDAKTASGIFLPTSATNQPLPEATVIAVGPGAPNKDGQVLPTSVRAGDRVLLPGWGGNAIKVGEEEYFLFRDSEILAKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0P8</accession>
    <name>A0A401H0P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1202320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027763118.1"/>
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    <dbReference type="FunCoup" id="A0A401H0P8">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0P8"/>
    <dbReference type="GeneID" id="38784923"/>
    <dbReference type="InParanoid" id="A0A401H0P8"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019157349" evidence="7">
        <location>
            <begin position="23"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE88006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="374" mass="41525" checksum="176A66E661772FDE" modified="2019-05-08" version="1">MAAFSFSFLLLSLLCLAVLVDAADLYKILELSKSASEQDIRKAYKGLSRKYHPDKNKDPGAEDKFVEIAHAYEILSDSTKRQIYDRQGEEGLKAHEGGHQHYANPFDIFQTFFGGGSAGQQVRRGPTSLSEMEVNLADIYNGASIDFMIKKRILCDHCRGTGAASSADIHTCPACNGAGVRIVRQQLFPGMVTQAQVTCSECGGRGSTITRKCPHCNGAKILDHTQHYTLEVPRGAPEGHEVMFEGEGDESPDWEAGDIVLRVRSRKDKGGWRRKESGLYWKETIGIEEALLGFERNLTHLDGHIVQLKRQGVTQPGFVQTMKGEGMPIFEREAFGDLYVEYNVVLPTAISPDVKHRLLQAFHVSAEDHTKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0W3</accession>
    <name>A0A401H0W3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1202870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027763170.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="38784975"/>
    <dbReference type="InParanoid" id="A0A401H0W3"/>
    <dbReference type="OrthoDB" id="3266090at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="21770" checksum="56213875A0B5E29C" modified="2019-05-08" version="1">MSLALDGYSWYERDENGNLIPDGGSGYRLTPAALEAEREMWLKRAKERLPASTTELPDKYNPFLCRDIKPKPSLLQYGIAVKFDQLRSYANEKNLLEPAARKRGVSLSSLSVMPIVYEAIHGLEVACNARLHWAIPWIAGYNGMVVLYSNYSIFWEQLEEEHEQEVIKILQEELGVTEKPMWYWDVSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H282</accession>
    <name>A0A401H282_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1302860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619383.1">
        <property type="nucleotide sequence ID" value="XM_027763582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H282"/>
    <dbReference type="GeneID" id="38785387"/>
    <dbReference type="InParanoid" id="A0A401H282"/>
    <dbReference type="OrthoDB" id="3269807at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="131" mass="14507" checksum="23F6651A9805976E" modified="2019-05-08" version="1">MAAETVPIAAPLFQAPTGAAIAVLKPYAFPEEDILLDANVLPDPPAVVKHMKVGWSEHIPLTALTNQACQTAYNRSQNGKDVLKFEHGIIKVGHAPLNASREWWLTLAEFIEAYPHLIRIIRLHYSHPQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H287</accession>
    <name>A0A401H287_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1303610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619458.1">
        <property type="nucleotide sequence ID" value="XM_027763657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H287"/>
    <dbReference type="STRING" id="139825.A0A401H287"/>
    <dbReference type="GeneID" id="38785462"/>
    <dbReference type="InParanoid" id="A0A401H287"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="49117" checksum="8419EE9CD304F132" modified="2019-05-08" version="1">MSKPDLGPCPPRFVEIKKDIASSYPDFQERVTKAWNELLAELDTVTSEIAAQGSDYVPQVNFSELANLSSERIEEIRRKGSLVIKDVVDDEEATQWRQWLREYVTKNPSIDGFPAEDKQFFQLYWTRSQVRARAHPNVLAATSWLNNMYHVRSGAQIENVDLSTPLMYADRFRIRHPGVQWDAHPPHVDGGGIERWEDPTFRHCFEDILSGNWRQHDPYDLEDRINARSSMYGRVGQATIFRTYQGWLAVSGTAPHEGTLQVFPSVYLSNAYTILRPFFRPKEGAEDVIDSKNWEYDITSSDFPGVYSTGSGFRGPWPNTKTHPHLRLDETMVSVPKVNPGDMVFWHCDVVHAVEKEHIGNDDSAVMYIPAVPYTPANADYVVRQKESFLQGIPPPDFPRGHGEIDYAGVGRPEDVEAPIAKKSMGFMIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Q4</accession>
    <name>A0A401H3Q4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1500790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619989.1">
        <property type="nucleotide sequence ID" value="XM_027764188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Q4"/>
    <dbReference type="GeneID" id="38785993"/>
    <dbReference type="InParanoid" id="A0A401H3Q4"/>
    <dbReference type="OrthoDB" id="2776971at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="220" mass="23982" checksum="23FDD9B268DCBE5A" modified="2019-05-08" version="1">MGHSSKLLTPTQTVGDIFTDLLLQDVSAKLTSVLAQSGIGPIILWGEWAMLYYGVPISDNHMHLLVPDDQLETAYRVLLAAGYKDSPLPLIPVISSLDPNIRWEELGCPAHRIVGDLSHLRTHLAILIQNYSAAASTFDDANPGSFEHCAGLAIPSLPLLGESFLRTYFKSSDCRSRVRSILAVWCASVKLSGYAPLGVDAMRGVPGINEGMALYWERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H459</accession>
    <name>A0A401H459_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620131.1">
        <property type="nucleotide sequence ID" value="XM_027764330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H459"/>
    <dbReference type="GeneID" id="38786135"/>
    <dbReference type="InParanoid" id="A0A401H459"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="605" mass="65450" checksum="5C59AD90A6BF4AD8" modified="2019-05-08" version="1">MPAKRNPTSSTVTVTTGAGGMKTRRSTVQDAADDDDNVDDRGQSTDKNEPVPPADVHDDAGDPSREADPSRSGRSERDGVVDTPGDRDARTGAADDNTVGDQHRVSDTNMDEPQLSQLWNHTEDLLAAISARLDESDVASQQAISYANRAIREANAARARAANARRDFEEAIGKIRTSILRIKKRENPELDGLYTPREYPPYAADEAAHLSRPPVGVESDRPQSPPINSDDYVERSLDMLFRPRDRNETDATYNARLDGQTRFLDARGAEQRRREREARINETWQQAESRVDMRARWGSAMPFTTLRTAFGDAPPPEPPGGGGNNNPPRRGGLPARGRGPHSSGRGFRSGGFPGGGGDGGPPDGDGDSSPHGSGSDGDNGDDDESSERSSVRNLDRHATRSPSYLQGRHSMPRGSVPRQQQQPQPGYTLPAVDDPFMRDGVRIIHKKKVRQALPQRIALENFPLPDKYSDLDEDWHQFMGQLLKDNIASVTVASTLYVHLIPESNNYRLRDVAIHCAKCGVTMQMAQDALSVWARGTLPGPNAEAAPEQPAPGPSNIAPTAADSTQDGHATIAGDPVGNTPTEPVPRQDAVMTDVNPAAVNGNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4E4</accession>
    <name>A0A401H4E4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620184.1">
        <property type="nucleotide sequence ID" value="XM_027764383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4E4"/>
    <dbReference type="GeneID" id="38786188"/>
    <dbReference type="InParanoid" id="A0A401H4E4"/>
    <dbReference type="OrthoDB" id="3350619at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40397" checksum="3A109F188E048A22" modified="2019-05-08" version="1">MEAEANAGAVGCMDPKLWGPYGSEVVGPRRDVSSLWTAGLLLFALTVLTLRRVRLVDSIGHHLPSTIELFVCCCVTVMRRTPEYLPLSSSAVDLDCQSELPEDGTKTWLRARIPDTTNSLVFWSCVSVICSSILSFTLFTYGTVIAAPQHLSSSRGQALRRPNPYVNLDKVLQNVTYTFPPIVNFPPLVLQISTSDRHRTMREDSRQWHSRLGTVYPHDRHITVSHETSTILQFRNLDYAMERCVLTLTLPLKTDVLDPAISIHDPSILDVWVLNASLELSPHITGTWKHAPARRSLLATFAVSLDNLSLSGEFHCPSEEFTTLELACSSTVSACRVDFWQNLRLVPIGGIYITQSQSVFGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4M2</accession>
    <name>A0A401H4M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620275.1">
        <property type="nucleotide sequence ID" value="XM_027764474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4M2"/>
    <dbReference type="GeneID" id="38786279"/>
    <dbReference type="InParanoid" id="A0A401H4M2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="125" mass="14172" checksum="CF5B6306C5232E5A" modified="2019-05-08" version="1">MYLEFWNEEMTSSFHPLAPRNRLYFRRVGSAVICPLHRRSSIIDHPPWTLLLFRLAPSLEQAEYGPHVRPAGVRPHALRATSATRAMGVRDVSSSLRAVVLLVRPAPIPLFFAHECGRVPYQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4U3</accession>
    <name>A0A401H4U3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peregrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1601100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620361.1">
        <property type="nucleotide sequence ID" value="XM_027764560.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4U3"/>
    <dbReference type="GeneID" id="38786365"/>
    <dbReference type="InParanoid" id="A0A401H4U3"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PWWP_BRPF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bromodomain containing 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
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    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
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    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
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        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
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    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
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    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00293">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 9" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="184"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="474"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="14">
        <location>
            <begin position="1179"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="631"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="695"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="748"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="837"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="937"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1090"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1283"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="848"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1310"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE89448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1334" mass="148240" checksum="981642F0F21C5591" modified="2019-05-08" version="1">MARGVASPAPAPLPKVSFVKVQDDTTNQPTGVHDQQARSYGYNDFSDFRRPEHYIRYIEPLESELAVQVEYDMDEQDQEWLDAINAERKKEQMDKVSYEIFEIVMDRLEKEWFDLTKNIPKPDLALPSEDSTCAICDDSEGENTNAIVFCDGCNLAVHQDCYGVPYIPEGQWLCRKCTVSPENPVSCILCPNEGGAFKQTVHGDWVHLLCAIWVPETRVANDVFMEPITGVDRISKQRWRLKCSVCDIRQGACIQCTKSSCFLAFHATCARKEKLLMPMKSSQGSEAPALACYCEKHLPKEQQEARAAALAAEHSDDHAYDGRPPSPKSSKTARAYAKTYTPGPPLVPHVIVERILQYIGKVVLRHKREFVLLVCKFWSLKREARRGAAFLKRLHLEPWTASSGGKQQTDEEKLTKLEFMKRLRRDLDSIRTLTELSRKRESRKRDQAETIQDVFSRFLFSNEPPLRMAFERIMGFDRQDYFKNPVSKIDVPDYFDIINHPMCWTVIDRKLDRHEYWDLQDFKHDVNLVLNNAMTYNKQGTPFFKAAQRIKTSIEPILAELDKIASREAGYFDEATSPLVAAPSDSKLTIGDLEPPLYLLDLLVTEDVIKDQTSLIIGKEPLVSLFSYELPQFRPPPPPPLPKPKRNRRADRERKRREREAQAQGLDASPGFRAPRTRRAVAAAAAFEAEVAGSIQAGPSDASEDATTESVSAGSPRKRAKRTPASTPAQEPQVVQDVDNQQSFRMFDNGWIFPPDQRRGGRAPIERYPLPPPRKKLPKTSRDKSQLSTFSTSAAENETLHATTLLENAPELASAVPAPEATSEPMEVDQTAVEVDQVAPETEPENMDVDKPDERIPVPKPVITEELDTPGIRRKKNMQRRAERLAEAEAAVTATTTPSLEAETAATSTLVPPVAGPSEPIITVIDSPVVTRKKLVRRKAENRGATAAAEADAAPATESPGPSATAGPIIIEVLDSPTIRRERHMRRKAEKLAAETAIAAAAATPQRAVADSAVEAPTSGPSTITERIIIEELDTPMTRRKKNMRRKAERFAAATEAAAKAEARALVEAQASPTAALAEIEASTTAITSAWEPAAAESEAEEEEELDSDSDLTSLGDSTDDEVITEQPAANRSPASPRRKQPAQVHSAGPTTRRASRLQNAPPVEAGAVVLGDGEYLEGGTLVWAKAKSFPWWPAVVFEEDDPSIPKYVLDLKDESSQNEDKQLHVIRFYDSGNTWQWVRLPQLRMLGEDTSLDDDMLAKTSRRQKWKNQNVRGECRKAYRDAMAEREAEGDETEAGSKEAAIAPDGMGSHQTESATAVNNPAVPDSPMLEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5C7</accession>
    <name>A0A401H5C7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1602220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620473.1">
        <property type="nucleotide sequence ID" value="XM_027764672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5C7"/>
    <dbReference type="STRING" id="139825.A0A401H5C7"/>
    <dbReference type="GeneID" id="38786477"/>
    <dbReference type="InParanoid" id="A0A401H5C7"/>
    <dbReference type="OrthoDB" id="3346544at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="37222" checksum="BA5A2B640AA6E879" modified="2019-05-08" version="1">MPPLVSANLAAFCVETLLYGVFIVLFVASVYLQVRRQQQHAEASDRVATAMCRFRQRMCATPMFMPGICLGITVTAHWTLTVTRLFQAFVGIDGGNQPFLFFADLGQTTNVVKTAFLFASCMIGDATSIYRTWVIWNRMLSAVIFPLCSFIGVVVGGIGITCQFGIYKFAKDVYMAEIGRWVLSHCILTSFTNIYCSCMIAYKIWSTNRSVRAYTGGRTMGALIIFVESAALYTIWSLFFFISFESRSNLQLIVINAWAPVTGITYTLIIVCVAVRLVYKAPSYPQSLDLHLSPPNNEQDTMRPVAADISQVANVEDVPALSTSQPPADISQAIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5Z7</accession>
    <name>A0A401H5Z7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1701920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620779.1">
        <property type="nucleotide sequence ID" value="XM_027764978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5Z7"/>
    <dbReference type="STRING" id="139825.A0A401H5Z7"/>
    <dbReference type="GeneID" id="38786783"/>
    <dbReference type="InParanoid" id="A0A401H5Z7"/>
    <dbReference type="OrthoDB" id="3263571at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="238" mass="27869" checksum="E371D4A7D9E40373" modified="2019-05-08" version="1">MDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQYKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDEFLSYENWKEFIASVNKAFGDENIEETTRTLLRNIKQGTRTADDYIAKFRSLEFKAKLEDAGNIEYFKWGLNDPLRQRIYGMKSMPKTLDKWYEYASQFDNQWRSAQIFKRGATTMTRGKGRSVHRPYYSTSAKDPNAMDVDHINISRLSPDERQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H603</accession>
    <name>A0A401H603_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1702020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620789.1">
        <property type="nucleotide sequence ID" value="XM_027764988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H603"/>
    <dbReference type="GeneID" id="38786793"/>
    <dbReference type="InParanoid" id="A0A401H603"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="481" mass="53479" checksum="A7762A2374C81F61" modified="2019-05-08" version="1">MYRSDYLTTPFPKPTGRFAHIPVKSVYGTFDTSLNKAWDTVGPQIVDIIPGSTSRDTAHDVSQAILALLRKNNVKDVVVEWREAVPQWLAGPPLLRHASDRDATHYVRRFLTALLAVPLTTEDMEDDHSQGTLTLWFLENKTNDGKPSDKVYGLSNCHVLRKDTTVDYSLKGGAPKDHVRVCGMRRFQRGLDEITKAVADRVFFANMYAQDIARLQAQENQGPETADDLEWNRSKLEDENRAIASLERLHDEATKYWSNIKLQRNIGHVEYAPKIKVDEGNTRYTADWSVFVAAEAKVKGAFEGNVVDLGSKFSAPELTAMFYPVAGGATTFKYPSGRKLKISGCASKEDLAVPAEFDIQGERCLMVGKDGNTTDLTVGRYAGLESFTFNAAGVVSRELAIYNSGNKAVEVFSAKGDSGSLVWHMRDGKAYIVGQLHSGHNKGGSTSNHVTYCTPGWWLLAEIKKKYKNAVFYPETWPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H644</accession>
    <name>A0A401H644_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1702080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620795.1">
        <property type="nucleotide sequence ID" value="XM_027764994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H644"/>
    <dbReference type="STRING" id="139825.A0A401H644"/>
    <dbReference type="GeneID" id="38786799"/>
    <dbReference type="InParanoid" id="A0A401H644"/>
    <dbReference type="OrthoDB" id="2790161at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="333"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="453" mass="52413" checksum="EDEF59A0F4929622" modified="2019-05-08" version="1">MAASQSLGIQFMTSKWHNFYHALAIPFTAEFDSCKADAIRGHRDKYLDPEPHTCVWDHNILDGIHAWHKDPNQQQCIFATPEQLQIDPGPFHPALLRNEDDILYVGLEFMHRKIAQYNIATYEFAGEQVEFEIVKYRCAFLMNERDSEFSINFRHNISKITYKLTHIKLGDSRAMVWEPNHLTYLDIPLPCERKEVSCIAHAGKVHDEDGDTYFEELRLYLSGGQLPARCTPGSEAHRSFLLCAQCYMWHDARLWHLSIKEQPQLVITDKKRRTEIVEQAHNLCRHRGCDSTYKKLADRYYWPNLYDDVAWFIRSCNACQYRVKSRPIVPLHITISPSILRRFVFDTINMPTGIHGEKFLIHSSDNVSRWPEAHAVKRNNSKTWAHFIFEDIICRFGCIPICVCNGGAEFKDAVHAIFDKYGIAVIISTPYHPQGNGIAERDGQTLSQAIMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H646</accession>
    <name>A0A401H646_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1701850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620772.1">
        <property type="nucleotide sequence ID" value="XM_027764971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H646"/>
    <dbReference type="GeneID" id="38786776"/>
    <dbReference type="InParanoid" id="A0A401H646"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="134" mass="15357" checksum="DF35E529EE1AA0C6" modified="2019-05-08" version="1">MNPWNKLKSYCCAVVYIMMRKKRTPNFEQFTVLEETTDGINYNHYIVPWTRNIVWHTEYASVGNKVSAWTSFYTASTTDVGDKDVPSFDLSELCGPTSDIPDDDEDVDLFDLDPRYLENVEKWCRGSSTSGMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6G0</accession>
    <name>A0A401H6G0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620951.1">
        <property type="nucleotide sequence ID" value="XM_027765150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6G0"/>
    <dbReference type="GeneID" id="38786955"/>
    <dbReference type="InParanoid" id="A0A401H6G0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="149" mass="16360" checksum="3FC61DBF9449A491" modified="2019-05-08" version="1">MTPIPLGEHRRVVQPTRRIAALRDSRASFSHDKYLATLDLERLNTRASISPSLSTHQHQRRPSKYREQTPRPRTPPPALPNSPHGLADPARATSHPRQRPCPPLPGIALPPSAPRELANRLFSPSPLLPFSPSLIATPSPAAPRSGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6L6</accession>
    <name>A0A401H6L6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620913.1">
        <property type="nucleotide sequence ID" value="XM_027765112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6L6"/>
    <dbReference type="STRING" id="139825.A0A401H6L6"/>
    <dbReference type="GeneID" id="38786917"/>
    <dbReference type="InParanoid" id="A0A401H6L6"/>
    <dbReference type="OrthoDB" id="2751518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="56"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="553" mass="62309" checksum="A7723CF72F87EAC7" modified="2019-05-08" version="1">MNASNFTPWPEWCGHPEVFLEKIRSERHRTSMDELLSLERCLCMALSLVRSSTCPINRLPIEILGDIFLLVMRPVKPKHAFIWNSSRLRHTRGLTVLTKVCRHWRDVCTNFPFLWSHISGAPRDADPPIPLFLQRSRPAPLTVYLPANSIPSALSLLELESESSRIQELFVHSFTEVAGLRYSPAPALEHLTLRADYVVPRAHQHIILFDDNVPRLKTLSIHTIDWLPSNHFASITHLCCYFSANHRPYDGPRASDLLAMLAGSSRLEDIVFVFPTFALHPQNCGSRPNAKLDHLQRLALGGMSPTWLSWLFCHVDMPVNVAMRIFQVKSRHIFRTVHVLAQALLQHSSTLLELRGSPTSSSAIFGTTAAGYSTGIRIDVNDEDHKFLHTPSLLSQLCSLRGVQELYIDIVDFTSERTIDLGPLLQFLPSLSKLAYRHRSPSWQLSSSLLRFLKDCLGAEGGDSPCCPDLAVLHVIVGDSHLIFNTVVELAEARADAGIPLREAVVGYEGDGLDGCALGQFVQRVEMRPDHRLSRARWPTVCTTRTHRYWPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4S1</accession>
    <name>A0A401G4S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608078.1">
        <property type="nucleotide sequence ID" value="XM_027752277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4S1"/>
    <dbReference type="GeneID" id="38774082"/>
    <dbReference type="InParanoid" id="A0A401G4S1"/>
    <dbReference type="OrthoDB" id="2919059at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1280" mass="142099" checksum="4A23F5EDAC72EF64" modified="2019-05-08" version="1">MDPLKQYLHILKEDIAWHKFVDDGQKWPPNVRELCGGLLTDSRWVPLWITTGPYPAVDPRTEPLLEELQNTFKSHAGSLEDAVFDQQLRGMFGTLLSDCARLRNVISSDILCGSANPKESFLIVMIFNLMSSVTADFSIDENVLVALPRYRGGGLNVPMRFMSNSIQVPLLMSVFAEIPDDNSNADAPDAMENDPDADEADSDAESPNLDAEQHEDESSEPSEPPQPVSVTSPMSMSTFLSLCAKPVLVEESDSDSESLYDPPPPAELNAHILVYPSSRELPKRCPLPFLCVAEEDDLPLVMMAIFYQRHVWKIHEPVVGVRFSKYDTSISFYTGWLDENVDKEGSLPRVHIGSLGRDGSLDLALLEGAFALCHAGLALQGLVVRTCSAAEATVTLVAEEIQDDSISMWRLDTEGVYSVDSPEGQYDRTEAWAEGLAYKYPATTMIDSKKTAQKARKEGTSDLSGPSVGSSNSTGSTPSSESMVAIPEVELEQKGESQGSKKSVYKPMSFSSFTAEAAKRGKGALMHDYLFDRCVVLCALCRNPVIFSLYEIYAGDVWPLHWKTLNDMPSVDPSLEPFRQELFAQAQQHRELSAVAPQDVPVEILPLLEGSLPLILAVAKRAQGKARSVIPPSESVWRHDFNSLIFDFFTNALNGANSLYSPGSCSSDAPKLQLPDDDRVIPSTERMIHLPKAVGMDQRSAGDLFLRIGSGLSSGETYEKMLRQRIGRNEDLLEARDREQNAQFQILTHAQDWRQRRKWDGYALEHLKEDSYRAICDALGTVSIDLPVRRESLAAMQLVATAPPKPPYMGAYEDKESMPRANALNGTISLYSRSSLSSDAPMRQLPDDKSIILSTERMIYLPKAISMDQRSARNLYFYILRSGPNSDETHNEMLKQRIGPNEDLLREADDLEWKAYVQMIHHATDWLERRRMNGYALERLKEDPYRAICDALGTVSIDLPVRRESLAAAQLVATGSPKAPYVVGMHESKESLDMPDDTSSGAAPTIHLRQQLYSSAPALETVPEVDDPNQALPLDPGIPHSTGKVLPPRNSPKTAPLPTRDYAIAASIVCDTDHLYENAEARAYLDENLEAMSERLEVLTAGQRKNAKVKNPVSVLELPVFMMEYKKQDTDIGKGENQHRLACTSAATFLDVLGLTKKPVFSGLTNGPRVALAAAWSNDGFIEIFERQTRTMDISMALGAFQFASVLARLAIVYSKDLVDTFDEVSKPLLIKQLNDREFEKPDSKLQWKQLVPLKSERGEFENVTGQSVWTSEMEETSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G523</accession>
    <name>A0A401G523_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0101350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608175.1">
        <property type="nucleotide sequence ID" value="XM_027752374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G523"/>
    <dbReference type="STRING" id="139825.A0A401G523"/>
    <dbReference type="GeneID" id="38774179"/>
    <dbReference type="InParanoid" id="A0A401G523"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="200"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="347" mass="36975" checksum="E154DBEC4BB85936" modified="2019-05-08" version="1">MSVPIPFSRPATPGPQLLNIGWCGLGSMGFHMARNLAKYRGSLPSTSPLLVYNRSASKSQELQKLLGASKVEIAESPEQLVLECDIVITILATDAVVKTIYEQFAAALQKSPPTKNKIVVDMSTIYPAVAGELDSLISSIPLTHFVTCPVFGAPAAADRAQLVCILAGDYRSKKEVAHLLVPAVGKKAMDLGGNIEKAPTFKLIGNSMILGTLEILAEAFTLADKAGIGSGTAYEFVKDMFPAPSWINYGNRMMNDDFDGSTGFAVDGGLKDAVHITRLATELNSPMPAVDAARRHLLTARAQQSAQALRGESTFELLDWSSLIAGPRVGAGLEPFDSGKNTKVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5C0</accession>
    <name>A0A401G5C0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0102270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608267.1">
        <property type="nucleotide sequence ID" value="XM_027752466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5C0"/>
    <dbReference type="STRING" id="139825.A0A401G5C0"/>
    <dbReference type="GeneID" id="38774271"/>
    <dbReference type="InParanoid" id="A0A401G5C0"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019360780" evidence="2">
        <location>
            <begin position="20"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="122"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="467"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="748" mass="83340" checksum="D230D834AA388131" modified="2019-05-08" version="1">MRMFFLLLLASFGVLLVDASSSDVQGIYSLVQRLIPQHQNSFTFNLVEGKGDVFTISDTSGSNGAITVDCTTTSACARGLYTYVTEFGGVDIYWTGSRLNQLPSELPPVGSPVSGSAIVPYRYFFNTVTFDYTCVWWNFDQWSLELDWLALRGVNLPLAWVGYEYTLEQVFLEAGLTQADIEDYLSGPAFQAWNRFGNIQGNWGGQLPQQWVDDQYALQQQILQRMSELGMTPVMPAFTGFVPMAMADVYPNASIIRGSQWSGYPSTLTNVSFLEPMDPLFATLQKSFITKQQQNYNVTSHIYTLDQYNENNPLTNDTSYLAGVSAGTFASLRAADPEAIWMMQGWLFFSSESFWTNPVIEAFLGSVPNDGMIILDLYSEAAPQWNRTGSYFGKDWIWCELHDYGGNIGMEGNLPAVTTGPITALDYPGSTMKGMGLTMEGQEGNELVYDILLDQAWSAAPLDINTYTASWVSRRYPVNPLPAAAQEAWGILSSTVYSNEDPNTQATIKSIYELAPNLTGLIDRTGHHPTEIPYDTSTTIVPALRLLVQAVEENPELKCVPEFVYDVVDVTRQVLSNRFIDEYNTLVATYNSTYATPDTVAAAGEPLLAILSTLDSLLATNEYFLLSTWIADARSWAGNNVTYANYLEYNARNQITLWGPTGEINDYASKAWAGLVGGYYTQRWESFITYLEDSVKNETPYNSTEVADAMLDIGEHWDLEIWGQRAGETWGVTGNTWDVVNEVLGQWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G623</accession>
    <name>A0A401G623_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0104880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608521.1">
        <property type="nucleotide sequence ID" value="XM_027752720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G623"/>
    <dbReference type="STRING" id="139825.A0A401G623"/>
    <dbReference type="GeneID" id="38774525"/>
    <dbReference type="InParanoid" id="A0A401G623"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="84"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="247" mass="27370" checksum="C000600ECDFA57D2" modified="2019-05-08" version="1">MDDAWQSQDMAPPANGGGISIPTHDTTMSNGTGIGSADDQGWNNGEPARAVEPPRRSSRSRSPGARGDDRARGDGSGGGQNPGNNLHVSGLSNRVDTRDLEAAFAKVGRIKKAQVMYDPHTRESRGFGFVTMETGEEADAAITALNATDLMGKTMTVEKARRGRARTPTPGRYYGPPKRNEYERPYDPRPYDSRYSRNDDRRRPRYDDDTRGGGRDYERGGYRDYDRGYGRDYDRRGGGGGYDDRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6C7</accession>
    <name>A0A401G6C7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0106030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608634.1">
        <property type="nucleotide sequence ID" value="XM_027752833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6C7"/>
    <dbReference type="GeneID" id="38774638"/>
    <dbReference type="InParanoid" id="A0A401G6C7"/>
    <dbReference type="OrthoDB" id="2847449at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="11867" checksum="64B0D517AD799F62" modified="2019-05-08" version="1">MSNNDKDILNSMYRIHPLKEDNWMPWKRRMTAFLDEKKLLGYITGEIQKPELSANPDTREARDAEIQKWGEKDQRARNLIIMCLDDAQVIHMEGATTAHHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6H0</accession>
    <name>A0A401G6H0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0106310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608662.1">
        <property type="nucleotide sequence ID" value="XM_027752861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6H0"/>
    <dbReference type="STRING" id="139825.A0A401G6H0"/>
    <dbReference type="GeneID" id="38774666"/>
    <dbReference type="InParanoid" id="A0A401G6H0"/>
    <dbReference type="OrthoDB" id="3261505at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018965290" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="36963" checksum="81AFC26D1466D28C" modified="2019-05-08" version="1">MFATKPSQVILTLLCLVLALALATVSEANSFVPAVQRRDHVGVGRMIKKRSPDIFGQIINAGANAPTGSTDSTTPTSSSASSSTPAASSASSTPSSTPSSTPSSTPTPSSTPSSTPSASPSSASSSQPSSSSAATSSSASSSSQSSSSSSSSESTSSAASTAAKEAPVTSADTPTPTDSQPSETSKASNRYTSMTVTASPSATSAATSSSASSTSSTTRTTLIVIIAVASSIGAIAVGWTVIRKWKLRPSSHFDDRMQPIDWQPNDSDRRASVVSHGSFHSSGHSDPTTVGYGATSDHGHGTSPLNPIPDHDFTAVPSTLAPVGGYADLQRGSSPQPQMSEGLSRGPSLAHPNHGVPLHYQGGFDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G764</accession>
    <name>A0A401G764_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0108750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608906.1">
        <property type="nucleotide sequence ID" value="XM_027753105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G764"/>
    <dbReference type="FunCoup" id="A0A401G764">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G764"/>
    <dbReference type="GeneID" id="38774910"/>
    <dbReference type="InParanoid" id="A0A401G764"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="700" mass="77568" checksum="C2586FF72733C62B" modified="2019-05-08" version="1">MASIGGPSGYLVHLPEPLAVLPDHNTDRVPTMDRDDHDIYRGELSSTPRSTSPSSASSASSSSSTSGGHLGALTAVVEHAIARWARAWASSSSLETSSSSSDMSMVTMTKSQMARRRRRRRSIADAHNARSEREVAARIKAREESRHIPRAFDLYVPYPLDLPSAGTAADPDGLRKHAVHTSSLPLILSHLAATLRENAKARRGRIHTVSPEAPASSRLLLHDYMMPEQSAESHLSFALPDGPTRPRMRKGKRRAATAPAAAMQMTLSSGDETAWWLDVASPTWEDMSAIGKLLHLHPLTLEDILQQDPREKIELFPKLGYHFIAFRAIESQKTRELRSVSGGHEPSLGVMEEGLVGEVNVYLVIFRDGVCSFHFADIGEHVDRVRNKILKLAESVNMSSDSIAHGIMDSIVDSVFPILDGIEKEVAEIENHAASSFDDKGYSVETVQTTCDGSQNSSSNDQPSNDEKMESPISMTEKIELGRPVVRRRSLFSLPTNVPSLPRRLLYHIREIISHFRVVFMHSSILTTTATVHRIARTRKIVTSLARFLAHKSEVVAQIQKRLFLTGGTGNGKDYEMFIYMGDVQDHILTLQQSLAHYDRVLSQAHPTYIARLRLSLSRAQSGTDRAILTLTTISIGVVAVQMVIGLNSMNVLLPTNSHTGHRYWLFGIVISASTLVLLAYALLLRWWWVGAKKKRRNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7A9</accession>
    <name>A0A401G7A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0109370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608968.1">
        <property type="nucleotide sequence ID" value="XM_027753167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7A9"/>
    <dbReference type="GeneID" id="38774972"/>
    <dbReference type="InParanoid" id="A0A401G7A9"/>
    <dbReference type="OrthoDB" id="2537258at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="255" mass="28217" checksum="3C4619D8C264D271" modified="2019-05-08" version="1">MNALPPAPLPLDNNRFAYHPPHRIDQPLDTAIASVWHLLDQAPPPTLREILEAYKTKGDGDRDMLIAMLNAKSAEDQRLASVASLHRTMLDMYQAPMRPSLAPLHIADSHPAYPSSHYSNSLYHSHVHEAYDHPRRAEPSHSQPPPAAHQSRKRRRASQSPPPQPRAYRPRERLDQPAHDLPFPPSPFSSASTHSNRSGSGSPRSRESIAIGALLSSGSPASLRDRAVDAVSAERSTSGRTTSPRDRRDKRDGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7G5</accession>
    <name>A0A401G7G5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0109930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609024.1">
        <property type="nucleotide sequence ID" value="XM_027753223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7G5"/>
    <dbReference type="FunCoup" id="A0A401G7G5">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7G5"/>
    <dbReference type="GeneID" id="38775028"/>
    <dbReference type="InParanoid" id="A0A401G7G5"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="83" mass="9020" checksum="17CD071FD36B1DA9" modified="2019-05-08" version="1">MTLAVDLLNPSAETEKRSHKLKRLVQSPNSYFMDVKCPGCFAITTVFSHAQTVVLCGACASVLCQPTGGKARLTEGSSYRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7I1</accession>
    <name>A0A401G7I1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0110090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609039.1">
        <property type="nucleotide sequence ID" value="XM_027753238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7I1"/>
    <dbReference type="GeneID" id="38775043"/>
    <dbReference type="InParanoid" id="A0A401G7I1"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF2">
        <property type="entry name" value="TRP C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="437" mass="49438" checksum="21FCCEC4E6A5766C" modified="2019-05-08" version="1">MPRQPTQPTPSTIPQHHDGSDTKVPYDDLIDQYATSYKAYTVDPSSFHSSQTSHHKPSYSLTKQTNDSDITVKDIKDVEGESTERLDWGYPPPTTQPEKEKEKRKLWSVFLPDSIACRLYLLTVLVETAIDLAIEAEIFVRLQESRDANGSDNVASLKMPVYLSIFAIAHLFQFVMALDAVHARNTLQFIALAIFNAVFLVYAVIQIGEIRGSLPTTSGTSHIPIDVLTTIIPIVISVAELAYLALGWKIYTEFGWKVYKFLGADRQIKAMYAYFQIYLCLVKFDVFFWVGFSVQFIWLVLNSHNAEYYLTCLALPLSIVVLVIGDQAARRENKWMMLAFMTGCVGAMVYFLYKLVKVLRLKSTATFILVWQTLTTFSVIAIALLILTFVFACIVMNNFGRGLKTRVGNNSTLKQRGKSQDLYRGPMSNHPNRMSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G816</accession>
    <name>A0A401G816_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0111730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609202.1">
        <property type="nucleotide sequence ID" value="XM_027753401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G816"/>
    <dbReference type="STRING" id="139825.A0A401G816"/>
    <dbReference type="GeneID" id="38775206"/>
    <dbReference type="InParanoid" id="A0A401G816"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_bL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14511" checksum="52CF6E7CB69B5867" modified="2019-05-08" version="1">MAAIALRQTQFLLPAFRLPAWRPLFSAALIPAFLTTPRPFSWVTPTLQSLLELLPPFLLAVPKKKTSHSRKAMRSANKGLKDKRNLVHCPGCGSPKLSHHLCPNCYSSLNRAWKAEAKENGDGSLGGVPAVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G845</accession>
    <name>A0A401G845_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0112040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609232.1">
        <property type="nucleotide sequence ID" value="XM_027753431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G845"/>
    <dbReference type="GeneID" id="38775236"/>
    <dbReference type="InParanoid" id="A0A401G845"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="9058" checksum="7D5B61509680DB37" modified="2019-05-08" version="1">MLRFAALQKGRHFKVSHMNWETFFRILVHEEDDMSLASHDMIIGPADYSLKDSAYGLKKHNIKGYRKATPTSCCARGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G850</accession>
    <name>A0A401G850_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclin mcs2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0112120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609240.1">
        <property type="nucleotide sequence ID" value="XM_027753439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G850"/>
    <dbReference type="FunCoup" id="A0A401G850">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G850"/>
    <dbReference type="GeneID" id="38775244"/>
    <dbReference type="InParanoid" id="A0A401G850"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="83"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="349" mass="38945" checksum="2872218D2A511055" modified="2019-05-08" version="1">MTAPTTASTSEASSSKHSLYEGSTQYRHWRYSPEQLAQARTTLNAAAVKAIRDAFETDELGSSSSVSFLNADEELLLVKLYVGKISQLCGHFRFPEEVEATAVTYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNHPIALEAYTSHIPKTTPSDVLDLEFLVAQSLGFDFAVWHAHRALWGLYLDIQSLPDFSIEELRTAYEAALKHVRASRLSDAELVYTPSQIALACLALASPSLAYSWARSKYSDGHDPPVLMLLEPLKAMILTQGTPPEVEAVREVDRRLKLCKNPQKVVGSKAYLKKQEETVRKAEEKRKRKAAEVKKAMEDGDPFGCELADGGDLDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G866</accession>
    <name>A0A401G866_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0112370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609265.1">
        <property type="nucleotide sequence ID" value="XM_027753464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G866"/>
    <dbReference type="STRING" id="139825.A0A401G866"/>
    <dbReference type="GeneID" id="38775269"/>
    <dbReference type="InParanoid" id="A0A401G866"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="2">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="321" mass="37293" checksum="9C5E6552C607E1EF" modified="2019-05-08" version="1">MDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETAHTLLRNIKQRTRTADDYIAEFRSIESKAKLEDAGNIEYFKWGLNDSLRQRIYGMESMPKTLDKWYEYASQFDNQWRSAQIFKRGATTTTRGKARSVHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRIKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G974</accession>
    <name>A0A401G974_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0116030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609625.1">
        <property type="nucleotide sequence ID" value="XM_027753824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G974"/>
    <dbReference type="STRING" id="139825.A0A401G974"/>
    <dbReference type="GeneID" id="38775629"/>
    <dbReference type="InParanoid" id="A0A401G974"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="11033" checksum="3C516D5E4BE6F774" modified="2019-05-08" version="1">MSSATPPSIKQLKSLLRQALRIRILDGRIFLGTFVGTDKQLNILLVNAEEYRIGNDRTDESANGRYVGQILVPWRLISTAEARAGLGIGLGSLDSDDSLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Z2</accession>
    <name>A0A401G9Z2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0202030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609919.1">
        <property type="nucleotide sequence ID" value="XM_027754118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Z2"/>
    <dbReference type="FunCoup" id="A0A401G9Z2">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9Z2"/>
    <dbReference type="GeneID" id="38775923"/>
    <dbReference type="InParanoid" id="A0A401G9Z2"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019282705" description="Thioredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="178"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="597" mass="66301" checksum="2E7C831E9027FCE4" modified="2019-05-08" version="1">MKLSAALAQLPYSLLVASLTLTAIAAPVESVGLDVLEPDNFESTIAQGVWFIEHFSPYCPHCRDFMPTWEQLVADTQKSADPGIHLAQVNCAINGDLCTKNGVTGYPQMNLYRNGVFQEMFSGARDYDRLTAFISTHAEPTTVAEPEPEPEPEPTSAPAALVVEDRYIAEHRESYRAAPARDLNPSGTVLELNENTFRDVVDDGMIFVKFFAPWCGHCKKLAPVWRELAVEMQHKLAIAEVNCDDHNALCHAEGVTGFPMLVYYGGKDGGKTEYTSGRKLEQLKAFAEKISGPPMREMNFEDLHARVEEHPVLYLLLHPPTSNWPINHLLDASHILFGSPPIYTSTSSRLYSHFGITPDASIILALKDGDDAAPAAVYQFTTQANADHEKESLTSWLLRNRLPLSLALSSDNFQDVMNAPHKPLVVLAAAAPSALQADIAPEMRELARQWRDARGSAAVVFAWMDAERWASWLKGMYGIKPDALPRVVIADHSGLVYWDTDHFGEKIQLSSSSLFSAINGALSRTIKPKHSENFVERMARYLNGRLMATEKYVSAHPWSTVCFVLLFVAVFAWALLRLFADSPEFREVARGKGDRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA40</accession>
    <name>A0A401GA40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0202410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609957.1">
        <property type="nucleotide sequence ID" value="XM_027754156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA40"/>
    <dbReference type="GeneID" id="38775961"/>
    <dbReference type="InParanoid" id="A0A401GA40"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="503" mass="56537" checksum="6C4F7C616A6CE646" modified="2019-05-08" version="1">MRPQTVEVSHDIAQDIINLQGTEIASLRRELDAARSRIASLEKTVVEGDESKVLCQELRILVTEVTNVRNLQEKVQKTTYTNESLRDERKNLQEQLKETKNQIDALKLQLSEELKDQKSLMMRIAQLESVNEDLKAKVEQSNKVEQLVRELQSLVELVIAQNRAPKSHTSEREDLHVSLKCTQIAFAEASLRNDTISRELSEVCASRDALQKQIECCEVRNDVIQSELSEACMSRDALQEQLSLSESQNLTLTKESVLLRESYDSLQDEVDRCKASCASLRMQVFSDLGMTPQSMPESLPSCMAEIECISRQAKEMQDQILKEERENRRETQDLMQEQISRLLDAVTEQEISLRTAREERDKSQESAATLLTDMTVLLAEIAECRSALDTAKAQEQLIEAAVASPRPEAISDDLGPGAPAKDFPGEPSDHNIVTQYAGVDCARVAEWAVLPPRGLGNTFDSVETMFVPFATHAVSLAIIQKTLLPLLEVLRMFVSPVHKTWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA61</accession>
    <name>A0A401GA61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0202610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609977.1">
        <property type="nucleotide sequence ID" value="XM_027754176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA61"/>
    <dbReference type="GeneID" id="38775981"/>
    <dbReference type="InParanoid" id="A0A401GA61"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="9235" checksum="FCA2933744AEF37E" modified="2019-05-08" version="1">MEDVKPQVPGVKAEPIDVDLQPLSSEREDEAKYEPMTEEEIKAAVDRLQNICEDSTLCIDLIFMMFRTTASRENQERFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB27</accession>
    <name>A0A401GB27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0205490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610264.1">
        <property type="nucleotide sequence ID" value="XM_027754463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB27"/>
    <dbReference type="STRING" id="139825.A0A401GB27"/>
    <dbReference type="GeneID" id="38776268"/>
    <dbReference type="InParanoid" id="A0A401GB27"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="751"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="841"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="922" mass="103829" checksum="A8F1B47CD87CC311" modified="2019-05-08" version="1">MSSWSGAAYPPPAPPPRGRSRSRSPYRGVHPPRPVFPEPVYGQDPYRADWDAYDRERAWANYERERAAYEYSRRGRSRSPPAEEAGRKRRRSLSPWDRERYEPRPRYQEDYDAHSRGYGYASPHRGQYPPPPPPPPYGSSRRAPPDPHTFDYPASLKQYAEWFRYYYPQQAIEEDNADKAAEQEAGDGSKPRNGIRARWEKYKKDFAAQQLQRMFDHHRKSPWFAEKYDPAPEYTNMRARVRKVGWRGRIDSFLLDVEAGKFDPDLNEPEPEATSPVKESTNGDAASNATEVTPAQASAEETKPVVTGDEEMQFNVEPEDEGGDNDASRLDTNGKTFNDLKRPNRGEEISVQPEGNQVMIRTIPPDIGRVKLEDACGNIPGFVYLALGDPLQKRNYYRAGWLKFRDDADMSTVMAELSDKKIEGFKLHVAHNIKPFTSRIRYAPEVASKPDRLAKDLENVKTLAAILEAHYDTLRKLKVAPKEQNGDASALTNGDAARAEQPDAIMSDAAAVEEEDPEPRERGSDAVERRIEKIMADIRDQGLVDASDEKGLEAKKTVVSLDLYLAYLRAAFHTCYYCAVVTDHQEELQRKCVKHMRKPLSKMLLQEVKAAEAQKAQKEVKEEEGDEGKSKDKDKEVMGKEKTSETRDWKRNDERWLEWLDSKVALLVNRDGVDPRDYGGKSYDSELSKACEQYIKQEDEGKYRCKTCQKLFKATSFVEKHIANKHSELVKHLEEIPYFNNFALDPHRIQPFSHPPQQVGNSQAPPPQAYGLQGPAYPPGDYGRAAPYQGSYGGAYPPPYTAGYWDPYTHPYPPNAYPPPPVRRDEGVTARRLSDRISGFAPGYEQNVEPPPVPASAGLPAKPVASLEPGPGGRRGGRGGAGVGPLPPPPPDAKEDPRAAAGKKVSYHDMDLVAEGDVELTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB30</accession>
    <name>A0A401GB30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0205720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610287.1">
        <property type="nucleotide sequence ID" value="XM_027754486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB30"/>
    <dbReference type="STRING" id="139825.A0A401GB30"/>
    <dbReference type="GeneID" id="38776291"/>
    <dbReference type="InParanoid" id="A0A401GB30"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000046">
        <property type="entry name" value="Geranyl-CoA carboxylase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000091">
        <property type="entry name" value="Probable methylcrotonyl-CoA carboxylase beta chain, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="43"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="303"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="556" mass="59390" checksum="DB2CF4A6462443B6" modified="2019-05-08" version="1">MRLASPSFQAFRRGLIHGSRRAYVLPSLISPSAPEFVAKAQAMSALVADIDAKMAAVRQGGGAKAVERMRKSGKKLPRERLAALLDPHTPFLEFSQLAAHDVYPDNVPCAGIITGIGRISGRECVIVVNDATVKGGSYYPLTVKKHLRAQEIAREHGLPCVYVVESGGAALPHQANVFPDKEHFGRIFYNMAQMSALSIPQIAIVHGISVAGGAYVPAMADENIIVREQGRIFLAGPPLVKAATGEEVDEETLGGGQMHSSESGVTDHLARDDEHAIAIARGIVGDLGKAGGQEVPPPSVPEDPLYPASELHGIVGTDLRQAFDMRDVIARVVDGSRFREFKKEYGQTIATGFAHIHGYPVGIVANNGILFSQSALKATHFIQLCSQRQIPLLFLVNVTGYMVGSKAERGGIAKDGAKMVRAVACADVPKLTVIVGGSYGAGNYGMCGRAYSPRFLWMWPNAKVSVMGPGQLSQVMATVSKDPTKHSNLKDEIEEQSTALYASARLWDDGIIKPTDTRDTVGLALSLASRKRGTNAAGGVPTTWDGDSKGFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBH6</accession>
    <name>A0A401GBH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0206830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610396.1">
        <property type="nucleotide sequence ID" value="XM_027754595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBH6"/>
    <dbReference type="STRING" id="139825.A0A401GBH6"/>
    <dbReference type="GeneID" id="38776400"/>
    <dbReference type="InParanoid" id="A0A401GBH6"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="742"/>
        </location>
    </feature>
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        <location>
            <begin position="766"/>
            <end position="781"/>
        </location>
    </feature>
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        <location>
            <begin position="810"/>
            <end position="840"/>
        </location>
    </feature>
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        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
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        <location>
            <begin position="857"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="982"/>
        </location>
    </feature>
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        <location>
            <begin position="992"/>
            <end position="1036"/>
        </location>
    </feature>
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        <location>
            <begin position="1046"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1268" mass="131507" checksum="2BEE424C51E674D1" modified="2019-05-08" version="1">MDFESSDILGGDLSISHDVSLGAWSLARASLAGFILLPAAFLLLHIFAGLYRWRDSTQKKATRRRHGIPDYDHRPFPIALGAALRAREQDTAARSREKEKDETSVPQSHPVQPNLPQLGQRVSHLADTHFSPAPPNNIVAPVIAIRGEVGPATGYSGVPENAGQDVAANIPPTPLANDLNHPKGDPPRVHRKHAREEEGPTRSGHKRSRTEGGSSSDDEKLSAARESEKEMDVDEEIAPPKRGFKRTASHVVDEGHQRSGGRDKRARKAPRDKEPQEYLVDEEMRDDEATSRNQRGKKRVRVEMGEEGSVVEDDEDEERGRRRRKRRAMAHKKPDPVRGQKRAREAEALDSDEEEPKRDSRKKRGKKGHVAYDLPVGELSQDPLCKGRHVGEEWEVNGMHYKVGANGQRLRREVVKQSRSRFHMPSDSHHPDRATHIDVFVETWLSEDDYKAAKDRQELAWQDSPKVVSEPATPGDVPHTPNDGKGLLWSSMMSQDDSPSPVPPREPFMQSIATNVGLHLNPFQPDALSRRVSSVHQIDPEPSAVESPKIHSSRSYSKWEKQNLEAAAMEQMRVKQLQVARASVDTGKATAALTMSASSLAPAAAIPSITLTPPGDKPSQPDQQKTPAPLSFGGPSIGASTDTHMSVPKLTIPESTPASSITSDTIKAPTSGSPAAPTTTSSTAQNKFTFTPSTPSLGTQFFGQSGSGATPLPSSTSSVPNFFGAKGASTSAPTSSITAPASNLFGTTKPPAAGQASAPAKFSFNFAPSSAAQTGASSTPHGQEDSKQSEQSEQSKVPASNSLISRLGLTPASTASQTPSTTTAATGFFTGITPTFGPPAVLGSNASADVGQTSGSPFADAGAATTNAAPSSSTPSPPKFSFGFTSKPTSTTPTPASTAALAAEAPKPAFSFNFAAPVPSAQPATPSASSGSSSAFGAFGGSAKPFGAPADSSTSGMSGAAPAKPIFNFGSSSSTAFSSGTTQLADSNKPKFSFGNAGASSSSTPSAFGNTASTSSPAATNTTGPSTAPTAAGAGEAETKPKFSFNFGSTASTSAFGAPSFGNQATAPALGTQPTTSNTNAAPSAFGATSFGNNSAATPSAFGASSLTNNATTAPAFGTQPSTDNAAVPAPSAFGNPSQTPTPSAFGFTNPPQASTPSAFGFTNPPQASTPSAFGFTNPPQAATPSAFGFTNPPQAATPSAFGFTNPPQAATPSAFGSSNPPQTSTPSALGSSNPPQASTPSAFGLSNPPSDARVSAFGSSSNAEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBL5</accession>
    <name>A0A401GBL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0207550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610468.1">
        <property type="nucleotide sequence ID" value="XM_027754667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBL5"/>
    <dbReference type="FunCoup" id="A0A401GBL5">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBL5"/>
    <dbReference type="GeneID" id="38776472"/>
    <dbReference type="InParanoid" id="A0A401GBL5"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="382" mass="42979" checksum="7A3235AD07DAB8B4" modified="2019-05-08" version="1">MSLRFLQFLTPPQPVTRPEYDGLEFRWRMLTFRPALFKQEAVILAIALVYIAAYFIGKKMNANRANKWFKEQRSILTAQFSRPWQREGLIQDGSSDFFIYSTGRRALTSLHTTLSLRPRHDLAQVAFQFGRGLIELDYKPCDEVELNFAFRNTPGKEGVPDCVWAVVAKDQIRGIKENRWDLTFTKTTDNPSLPPSLTVMSEIADVTTNLLKPLGTLSLPAVLSDPALLPYFRSLSLTDQPRTRPKAPPVPGAPRTRHLILSLALPPPSAAQAVRPLIAASFQLVDAIAGEGKVFGSRGGLAAALRPETKSKLRKVREELARELKEEAGKEKAEEKAEEKAAAKKKAEEERLSKLSASDQKKEMEREKKRLMRKTQGKVKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC20</accession>
    <name>A0A401GC20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar ATPase assembly integral membrane protein vma-21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0209370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610649.1">
        <property type="nucleotide sequence ID" value="XM_027754848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC20"/>
    <dbReference type="FunCoup" id="A0A401GC20">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC20"/>
    <dbReference type="GeneID" id="38776653"/>
    <dbReference type="InParanoid" id="A0A401GC20"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="93" mass="9734" checksum="0276AC19BA04AACA" modified="2019-05-08" version="1">MSEQVAVEKVSAQAAQQGGVLIKLILFSLSLAVAPLSAYFLSKDYLWAGNATYAAITAVAAANVVLVAYIIMSVLEESQAGPSVTTVESKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDC9</accession>
    <name>A0A401GDC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meiotically up-regulated gene 86 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0213730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611080.1">
        <property type="nucleotide sequence ID" value="XM_027755279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDC9"/>
    <dbReference type="STRING" id="139825.A0A401GDC9"/>
    <dbReference type="GeneID" id="38777084"/>
    <dbReference type="InParanoid" id="A0A401GDC9"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="234" mass="24408" checksum="C187614972BD6795" modified="2019-05-08" version="1">MSEKSGAMHATDSEHGVPHSIINAPPPVVEAYKHSYADPAPLGMLAYGTVFFCSSLLTLHAGGVQSANLVLVFAVFFGGISQTLVGMWCMFLGDTFSATVFGAYGGFNFSYGALYLPQIGLAAAYSVDGVVTEEFSHAIGIYLAIWDAITLLFFIGALRTTLPVCATLGFTVLALTCLSANSFTGNPHLGTAGGAFGLCATAGAYYGALSGIYTRASTFKAIRLPPVVLAYQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDK4</accession>
    <name>A0A401GDK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0214580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611160.1">
        <property type="nucleotide sequence ID" value="XM_027755359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDK4"/>
    <dbReference type="GeneID" id="38777164"/>
    <dbReference type="InParanoid" id="A0A401GDK4"/>
    <dbReference type="OrthoDB" id="3257332at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE80247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10487" checksum="38D3105FB536BC35" modified="2019-05-08" version="1">MKIKDEAHTHFKAFIECAEVKTRQHANILWTDGDGEYKSKKFDAYLKAKGIHHEKTNAYTSQENSVSEQMNCTVEEMAWCMLNDAGLLNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFJ0</accession>
    <name>A0A401GFJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0306160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611808.1">
        <property type="nucleotide sequence ID" value="XM_027756007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFJ0"/>
    <dbReference type="GeneID" id="38777812"/>
    <dbReference type="InParanoid" id="A0A401GFJ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="138" mass="14978" checksum="3D8C405BC1CD72AE" modified="2019-05-08" version="1">MARRAAAATKSARYGLGTACNYGHLGSAWTGSWLDLRLGRRHMPSSGVLLAEFGEAFFWVAIGPERFHRRFPPDRRWGAGDEAVGGGWTPSVPRTRSARRCGRGAVPGSDTVRGRGGQEDWQGASVRMGETRESENSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFK3</accession>
    <name>A0A401GFK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0306900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611880.1">
        <property type="nucleotide sequence ID" value="XM_027756079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFK3"/>
    <dbReference type="STRING" id="139825.A0A401GFK3"/>
    <dbReference type="GeneID" id="38777884"/>
    <dbReference type="InParanoid" id="A0A401GFK3"/>
    <dbReference type="OrthoDB" id="3248529at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="59697" checksum="A335101A05C76008" modified="2019-05-08" version="1">MTELSEVPSGEATDSFSRTSPALTISTPCISSQVEVDPLLSRKGPQEEPSLELQRSAESGTPEIAIIADVNTDTSAQSAVPEITPPASAPRKVVPLRTNENRYPRFSRGFLWEHCDQYTTPLASLSEHLRPIPGPPQNELNNPVSLRTITDNSDLFQVVTPIAVDCFEALLSSHPNRPLVDSVLRGLREGFWPFAETDHLEFPDTWDGGSIPLTEEASTFISQYAEEEEGLQRYSHPFGPDLLPGMYSMPVHAVPKPHSSKLRFINDHSAGPFSLNAMIDKANVGMRPDNVQDLGCNLLRVRKLHGNIPIWLFKSDVKNVYRLIPMHPLWQLKQVVSVNGLRRIDRCMCFGSRRSPDIWCSFMSLVVWIAIHIYSIEALQAYMDDNFAFDLLAHLVLYEPYHRYMPHQQVMLLRLWDELQIPHEDSKQVHGHALTIIGFHVDTQNMTITLLQESCTALVTHIRDFVTNAPRRRHPLRDWQRLLGWINWGLNVQPLLCPALQAAYTKIRGLATACTSVPQCPSQARSTLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFY7</accession>
    <name>A0A401GFY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0308040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611992.1">
        <property type="nucleotide sequence ID" value="XM_027756191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFY7"/>
    <dbReference type="STRING" id="139825.A0A401GFY7"/>
    <dbReference type="GeneID" id="38777996"/>
    <dbReference type="InParanoid" id="A0A401GFY7"/>
    <dbReference type="OrthoDB" id="2803381at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="589" mass="63620" checksum="24989E4D553C915F" modified="2019-05-08" version="1">MSLTAPGSSSSCRRRVPRAHSYCPEMHNLCSSTPSLQFDVLPTEHGTSFPVIPSPPDSSSPSTPPPLTCKSSGSYMRGVFSYEEVISSTPKRARAVSVSSTAHSPTLLPIGKRPAAQSFENPRKAERAARLGVGLGFTVSVPSFNAETARTERARRRHAIHFHSHAQFSEALRVILDCHEGVVSHSDRRDGVSESNDADDERNYLWGTDSEADDARHYYPECANMAVSRQLSVSALTAAFPSPPLSPPDFPLSFSQAPNVDPDGPLPPAPTIPACRTEFGPINDDFGGYRMTVIDPVESMARLEISMTQLEAFNPFRSGCDSWFTDEIHMGLCLSPEYNDAVSPIVQSTQGAVNNGTKDGKVDDEDSRGDPSDEGPLLSETPATIASTFAEYECASFISHSSIDSATNGPRKRQSIVSVGLLPSFDFEGTDLPTATIHNPPPRSSSLAGLRPPSLSILSSRSTPSLRLDVKISSSTTKTTPFLFRPVRQTCTPLSPSEPTPSLFPSVSASIQTIQSSTCLLRVVPETALVAPTTPPRDHAVETLRSFMHVTPEQQPSRMSKLWNRACSGMSAGLRKDKSAKWLRGSHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG46</accession>
    <name>A0A401GG46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0308650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612052.1">
        <property type="nucleotide sequence ID" value="XM_027756251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG46"/>
    <dbReference type="STRING" id="139825.A0A401GG46"/>
    <dbReference type="GeneID" id="38778056"/>
    <dbReference type="InParanoid" id="A0A401GG46"/>
    <dbReference type="OrthoDB" id="5319015at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Mmc1 C-terminal" evidence="3">
        <location>
            <begin position="417"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="662" mass="72082" checksum="737B1963CAAE6B54" modified="2019-05-08" version="1">MPTCLVYSLRPSFLPSVSYRYRDVLSFPKTVAVHLSRGRITPWAALSTATPAAVKPDDGSVAYQHTLTVLHKTRSLLPRIFPSGQQSVPGIESLEFWHELLASAYNDLSPTRANVIRIAVYGCDDFSGAQELVTALLEEPFASESQKESVRTRWKSMPDDRGSMIIQDAPSPASGSLSIHSSWLQRFGVPIQVLELRPPTHDPWSFGDLSTSKALLAADVPIVVCNPTSTPLPSLLSSPSSSPLNHPNAILVVTSPIPSVALSRHVQSLRSYGAPTLFIDAARALTALRVISVEPSSPVAVQKYQNEFEGSNLSSLTETIASVIASKSAASNVVAAIHAQTARALIQDSLSACHSTLERAVRGVDEISERVSTLEDRVEEARARVGLEVFGAPGGKNGEEDEIQRAVNVAKRDVERVMNDLTWWRLLWRVDDVREIVGGAIDRAWCKDLEMKLTFHAGRLAALQQSLTTSSMALLASLPSPSPFCSPVLQNTLSQLVSAPAYPLDAAAFTAPLHSRRHQLRFPTARLHSAAQQTVLGMVGSTFAGLGVAWAGWAGQLGLFDMGMQMETAIAVGMLGAVAGVRWAAGRFEKAKKRWWQDWDRVGEGLARDLKTTLSRTMDDRVLIVSKTACSGLEQLAAERRDKIDELKYEVTVLEEELQRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGI9</accession>
    <name>A0A401GGI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0309720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612158.1">
        <property type="nucleotide sequence ID" value="XM_027756357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGI9"/>
    <dbReference type="STRING" id="139825.A0A401GGI9"/>
    <dbReference type="GeneID" id="38778162"/>
    <dbReference type="InParanoid" id="A0A401GGI9"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="493" mass="56077" checksum="FDE4C4D3D5C805C7" modified="2019-05-08" version="1">MDPVDHLFHPGPAYPSYPHQPVYNFYPHRPSPPHSPAPVPLFHQQPPQDSHQRDPDQPVDQIHDDPPIDEEPLYVNAKQYYRILKRRVARARIEELHRLSKQRKPYLHESRHKHAMRRPRGPGGRFLTAEEIAAQKNLQADAGPSNSTSPDADDEDAIDVDRDIDRDVDMSVDSPIEPPKPPTFQIQQLEEQRVQPKLQALEEQDHSEKPRPPPASQPSIQPSIQPRPQRPRQPSPSYIQPQAQMQAQQQLQAQSQMQAQHQLQAHAQMRVQHPIQPQAPQMIRQHSQTRIQMQPQTQMQPPASAHSQTQQTIRRPSLTLQQQQQQLPQHSPLVHSQAQLQPQQQQQSQPMRSPTYEHPHQHQHMGMLHGTSPTNLMNVNANVGYHHPLSPAPVSPVPQDGHRAHEHSRHLGSHLQQVSSVQQMQDSPSQTTSPQMTSPQISLRAPYAAMQMHHVPHPHAHARHHHSLVGRGEQVYHDVVPGSEYGGGAPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGS1</accession>
    <name>A0A401GGS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hydroxybenzoate 6-hydroxylase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0310890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612275.1">
        <property type="nucleotide sequence ID" value="XM_027756474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGS1"/>
    <dbReference type="STRING" id="139825.A0A401GGS1"/>
    <dbReference type="GeneID" id="38778279"/>
    <dbReference type="InParanoid" id="A0A401GGS1"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF306">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="441" mass="48550" checksum="27C82B47BF6FBA45" modified="2019-05-08" version="1">MSASDLLAIEFVVVGGGIAGLCSAIGLSRAGHRVTLLEQQATKEQTPLSGGCRVPTNLTKIFFRWGMGKRLMEAGLVVRGAEFVSYETGGFQGGHVLEEEVVEQLGGEFICMHFGDLRRILFEAAEENGVTIKLNTKVLSINAHPERPSVTLASGEVLEADAIIGADGASGLCRSVILGDRDHEEYLGRMMYNSVIPISQMDDETRELTRKIQMTAWWGTDRGAMGFPIGQNLYSLHVWAPGEPNASERVEVGVERLESALEGCVPGLLRLAKLAMKVVRIPMTERPHLDEWIDPQGRLLVLGEGAHHLLAGSLYTLVVAACDGMALGRLFQHLTRRDQITTFLSAVQEVRQQRLKDVMQIASTNPFALTMPEVKPKSKDETETEEPPADKWVLLQEAFLNIHGFDPEDEVENWWVKWGLPLERASRVVSSDTAVSSSRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH31</accession>
    <name>A0A401GH31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0312010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612385.1">
        <property type="nucleotide sequence ID" value="XM_027756584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH31"/>
    <dbReference type="FunCoup" id="A0A401GH31">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GH31"/>
    <dbReference type="GeneID" id="38778389"/>
    <dbReference type="InParanoid" id="A0A401GH31"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE81472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="322" mass="34938" checksum="82F6F8BF50068D6D" modified="2019-05-08" version="1">MSGDDDSSGWQLTESDPGVFTELLKTLGVPLVVDDLYSLDAASLAELQPLHALIFLFKWVPSTAEPSGGQFDTDFPGFFAHQVVNNACATLAVMNAIGNIPGLPMSTQLTDLIGFTTGMDAQTRGMAITSSDWLREAHNALSPPSAISLDGLGLPKTSEEAYHFIVYLPSMGCVYELDGLKANPVRHGAYEESGEGWVAKAREVIEARIATYPPGSLEFSLLAVHEDPLPTLQAQLAQLHAAGKQSEAAELIVKLSVENSKRERWAFENSLRRHNYVGLIHALLLALAKSGNLDAAKEGAKTMMQERIQKRKERGDSTMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHC1</accession>
    <name>A0A401GHC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0312320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612416.1">
        <property type="nucleotide sequence ID" value="XM_027756615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHC1"/>
    <dbReference type="STRING" id="139825.A0A401GHC1"/>
    <dbReference type="GeneID" id="38778420"/>
    <dbReference type="InParanoid" id="A0A401GHC1"/>
    <dbReference type="OrthoDB" id="2757320at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59622" checksum="B74CA11D9C51404E" modified="2019-05-08" version="1">MHPCLYIQEIVRKVVEFVQEQSEYHSSMAAIARCCHTFNEPATDALWVTQWDLVNLVKCMPPDAWKEVETAENSDNFCVHFTRPLLPNDFTRFDSLARRVKNLGMELHSSPPKSLTKVYDLSPDVFVILDFHRGSQPLLPNLKALGCSPERSDISFDRMLLGPKLQSLFVKHEQWPPPSERDDRATNVLTYAPYLSPDIRVLTFYQNLTTPQALAVIEAIGKFRALQVLAFHFPPVRKVVVEFMNQLPSLRTLQDISIVDAVGFDFHEPIETVLPAMPALRGITMTVRDVTLGVAMLKALQETPLTYINMQVYLREGDLSFTTFFKAFEHLRVPERLTTIELHGQLSENLELLEIDPCFDVAKLKPLYPFRNLEHLHIDTAYPVNVDNSSLAVMATAWPNLNELVLGSLDAGTMPLVTLEGLVPLAKTCQKLQVLGLVVDASTVPQYPNSAWGDDCQNQALREMRVGESDQPEAPEEVAGFLSYLFPNITMVHTVDLDDDEEETTESNAWQKVNDLIGKKLLTVLDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIE2</accession>
    <name>A0A401GIE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0403500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612887.1">
        <property type="nucleotide sequence ID" value="XM_027757086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIE2"/>
    <dbReference type="STRING" id="139825.A0A401GIE2"/>
    <dbReference type="GeneID" id="38778891"/>
    <dbReference type="InParanoid" id="A0A401GIE2"/>
    <dbReference type="OrthoDB" id="5599163at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="242"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="479" mass="54367" checksum="34F091642F4D2CD4" modified="2019-05-08" version="1">MAAVSSLSSSMDLFPSLSSSASSVSSLSSSEELFPQIVSLQIEKPRVLYTLSSSFCSIGAASGVTTPAVAPGAFQIEHEAVVHGYGYKKVDKRVKPVPGILADEFWIMRHVPRDPMQNLPSLPFHPPDFIGRSRYTEERWWDLNINSDGFLWEEEVKLFDHILYLHEQVFAWDESKKGKFSNEYFEPIRIPYQQHVPWALRNIPIPPEICKQVIQVIRNKIASGVYEPSNSSYRSHWFCILKKDGKSLHLVHDLQPLNAIVIRDSAAPPQIEDIAEAFGRCSCYASFDLFIAFDQRTLHPDSRDLTTFQSPLGALCLTTIPMGYTNSVQIMHGDVTFILQDEIPHVMIPYIDDVPVKNGTMRYETSDRGYEVIPQNSGICRFIWEHAENVNHVIHRLEMAGATLSGKKCNICGPELEYLGRLYNYEGRWPLPSRIQKIVDWPACMTVTEVTWISWDLRSRSGLHQRLCEDGATSDYPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKP7</accession>
    <name>A0A401GKP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613627.1">
        <property type="nucleotide sequence ID" value="XM_027757826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKP7"/>
    <dbReference type="FunCoup" id="A0A401GKP7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKP7"/>
    <dbReference type="GeneID" id="38779631"/>
    <dbReference type="InParanoid" id="A0A401GKP7"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="271" mass="29868" checksum="5CF2DEE8DAA435C4" modified="2019-05-08" version="1">MSTETAHYIHGYHESVLRSHSSRTAANSAAYLLSSLRPDMRILDVGCGPGTITIDLAALVPNGDVIGVELSDDVLEKARANAAARGVKNVQFHVGDVNGLTYPDGTFDVVHAHQVLQHVGDPVRVLREMRRVTKPGGIIAVREAVFAASTWYPDLEGITEWNALYVRVARANGGDPYAGRRLHAWAREAGFDLANITKTASVSCYSSPEERAWWGTLWADRVVASEFARTAIEKGFATREALERYAQVWRDWIAEEDGWFAYIQGEILATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLR0</accession>
    <name>A0A401GLR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614040.1">
        <property type="nucleotide sequence ID" value="XM_027758239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLR0"/>
    <dbReference type="GeneID" id="38780044"/>
    <dbReference type="InParanoid" id="A0A401GLR0"/>
    <dbReference type="OrthoDB" id="3263651at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43333" checksum="E598A6E36CFD82C5" modified="2019-05-08" version="1">MWQKRAPVGHSQVGRHSRSPLPKSYAYSTVNASVPASVKTKLQHTLSEKSVQRRRNFFIWAPSLRLIGGLHLDAHSPITVASLYRWLTLLLSKPHEFNLYPVEILPTYAIFRYLAQPVGDALPRDSQECLRPGDVGVFVPGEDQTRFQYDVHFAGMQITYAEEEASSREAYRNHMTESFIEEVQTRDGHRCVLTGASSTDVPLAVCWIVLPCSIRHVRYYQGPEMTPVLADMTSYYAISNAWTLRADLAELFKSNQWGIDVGDNCRVVFFGLYDSYSGLLPQVPSNLPLSGPICERLTEHFARCLSYNILGGDILDKYDGFDVSGYLEDLGYFDGDDLDPADPGWQTELGKEVWELRFRLKCEERQNRSSQRNTDATDSDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLS6</accession>
    <name>A0A401GLS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0501690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614035.1">
        <property type="nucleotide sequence ID" value="XM_027758234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLS6"/>
    <dbReference type="FunCoup" id="A0A401GLS6">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLS6"/>
    <dbReference type="GeneID" id="38780039"/>
    <dbReference type="InParanoid" id="A0A401GLS6"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="214"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="401"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="507" mass="56589" checksum="04FE10077C79098A" modified="2019-05-08" version="1">MIREPSDFRLDVSLLARSPLVQMPLNYSKWDALELSDDSDIEGHPNVDKRSLIRWKQRDIHEKREERKHRIALLEADIACNAVLQPRLRTIADEVASKGPAHFSALVERFKTEPSPERPPTNAPEQQTYDEMLLNLMLTIWEEVKKAGIDKDDARLGELLVQGLEKHFVQMGEHQGKQKQELAQLQEDNKRKITSDDIHVGFDSHYVPPKPEPSPIKGAIEPSKPKKTTEYEVLNPKGVEGTTTTSVPAASSSSSVASDDELPELTPSLEQFSHLPLRGYQQSWDFIRSHRDVYVAGASDALLVAAFKAQNDGKAVYAQQCVHQSLLIQYCEKLGPDGVTLFFRKMVVADPRASSVFENDVAQTYAHLAERVRISKAEEAAVAGEEQIQLVAENPSQSISFNIPDGPPPEHLQLEGPGFEDVNIEDVRKALQMRWDVFQGFSEAMQEALKSQELDKVNKVLGSMSVKEAEDVVQLLDLGGILNFSSGGIRDETGEEGEGVEEQEVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLW7</accession>
    <name>A0A401GLW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase SRPK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0502320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614098.1">
        <property type="nucleotide sequence ID" value="XM_027758297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLW7"/>
    <dbReference type="STRING" id="139825.A0A401GLW7"/>
    <dbReference type="GeneID" id="38780102"/>
    <dbReference type="InParanoid" id="A0A401GLW7"/>
    <dbReference type="OrthoDB" id="2791589at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="56"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="425" mass="47501" checksum="0CB2110909401CFA" modified="2019-05-08" version="1">MDVTGNKSLSEGDTSTDAVENVELTFIEEPLGLRADQGYGYLQVEFGQRIGPGDRYEVLRKLGWGMNASVWLARDHEEECYVAIKALKGMATDLHFQGYMQELPIMECITEHIQQSGRPAYCATLRSHFIHPGKPNDGEHLCLVMDVLAGDIEALQTVSKAFPVPLAKRILRDTLRGLAELHASGCVHTDLKAANIMCNVPEATSEANLRLLLESSPSRRHPPEQSWDYFVEAAVSQPLPPPSIDQALSASFVIGDFGSAQFVDHQVISHITPDTLRAPESILQGPWDSKVDIWTFGCLVYEFMLGIPLFPRKHPVMEPDVYHLVQILKFTGEEFSPNLIKTYKYAPDFLDMETGYLARVCKPVTKVHFSLLFRRNAAVLALPEHDVAGAIDLMSRCLRIDPADRPTAIELVRESPWMQELGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMR6</accession>
    <name>A0A401GMR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0505540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614416.1">
        <property type="nucleotide sequence ID" value="XM_027758615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMR6"/>
    <dbReference type="STRING" id="139825.A0A401GMR6"/>
    <dbReference type="GeneID" id="38780420"/>
    <dbReference type="InParanoid" id="A0A401GMR6"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009580">
        <property type="entry name" value="GPI_biosynthesis_protein_Pig-F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06699">
        <property type="entry name" value="PIG-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="287" mass="31974" checksum="DB35CEBAE34A485F" modified="2019-05-08" version="1">MAIRRVRVPQPESTAPDRPTDVRTASSPANFLPFASYTSVTGVHTSLLAFTALFLPRTSVSFLTDLYPWQSKHTPIASDEPHRALRLLTENPTRTVAWMCVGAIVVQTWWASWLRGWMIEERTRGMAEGNAAEQTKQKLQRKHWDDLRLAAFGNAILTTLVVSTIYYILLVLFGAPIASHPLETSALALLLSLLTSFTSAYVLSPPSLRADSEALVSRLTWIRLFAELSPRTPIERAIVYPAAGTLIGCWSGAIPLGLDWERPWQAWPLPPAYAPSHSSPMHTWYPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMU8</accession>
    <name>A0A401GMU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0506120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614470.1">
        <property type="nucleotide sequence ID" value="XM_027758669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMU8"/>
    <dbReference type="FunCoup" id="A0A401GMU8">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMU8"/>
    <dbReference type="GeneID" id="38780474"/>
    <dbReference type="InParanoid" id="A0A401GMU8"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="303"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="580" mass="63272" checksum="89622AFE6477A6D7" modified="2019-05-08" version="1">MQAVRLYVERGGSLIAFGATTSVRQQRSARSNLEDMVKNMGVHEDHSLHFVDEASGTCIDLKFGVRSDDSAQPMEIKMPDGTRVDGVLSSGKSGPSDIAGGVDMEVLAEYADGASRNGAAGISCRISNGRAAFWDLYVEYPLTAEPACSILMVSTPTISAAQVGAAERQRQTLVHFTLERLGLQLPARSSTSRAVPLPQILTAHPSRPEIVAEILTALSIPDVSASSHILRDSNDTFYFHDSLKGREILDEARTLADTNHDPSNWQPKHVIAFLDGKLPSHHETPLFDMKQYYDALYATHSEADLKYTAGEWGMGEALLYGEVVTSTQTLLDKNHTLLSSFPTPLLSLATHQLAGRGRGSNVWISPPGCLLFSLLLRVSLSALPAVRLVFVQYLFGLAVVEACRYSDILGAHGESVRLKWPNDIYAGIGEEKKKIGGILVHTSFSEGKVDIVIGCGLNVLNSPPITSLAQLVPEGSDIQLSAERTVAVIMAQFEKMWGTFLADHGSFDAFMDLYLDRWLHSDQLVTLTTVNPPMKVRVVGITSDHGMLRTIPERNVWSGESGPRVMDSAVLARYFTQNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMV4</accession>
    <name>A0A401GMV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0505610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614423.1">
        <property type="nucleotide sequence ID" value="XM_027758622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMV4"/>
    <dbReference type="STRING" id="139825.A0A401GMV4"/>
    <dbReference type="GeneID" id="38780427"/>
    <dbReference type="InParanoid" id="A0A401GMV4"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="381" mass="41105" checksum="2AF5895DE52069E8" modified="2019-05-08" version="1">MVNTTGLLGVVLLVRHGDRLEFFQDPLTYNPAQTFITPLGSVEEYQLGSFLRSVYINTSSSSYINGLNTDVVNITQLDVRADASGEGSVIVNSVQALLQGLYPPTTDNNITLANGSTIIAPLGGYQYIPVDSVEEDLDISLNSFTDCPNFDAHISEFYSSPGFLAEAQEAAPFLADLAPYLGNRSTNFTNMWNIFDYVNVQSIHNKTFYDILPAGYEEQAYYYANYHENGVFTDPVSVGGIGNIAIQTILPSIFTALTSMADGSDGVLLMINEISYKPFISLFNVTDAALADPSIAGIVDYAAAVALELSAGDPEPLVTMKLKNGTTDAEFHTLSLFGTTGGVPLSQFIDTLAPIAVNNTQQWCAACNQTTLRGCSVYYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GND7</accession>
    <name>A0A401GND7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0507460</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614603.1">
        <property type="nucleotide sequence ID" value="XM_027758802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GND7"/>
    <dbReference type="STRING" id="139825.A0A401GND7"/>
    <dbReference type="GeneID" id="38780607"/>
    <dbReference type="InParanoid" id="A0A401GND7"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="171"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE83690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="343" mass="38029" checksum="69B5286E70EC1750" modified="2019-05-08" version="1">MSEPTAATTAAESTPDVSDMSVSLNEVQDVSPDSKVTETLDNHGPAAALDSTAVEPEPIPVAAEVNSSSEPTPEQESQESQNALTQKFTAEEWAAVKALRAKLPEVLKEAFPKMDQNVPITLWGVSITANGPHDARVSVVLIKFLRARDLSVTDAQQMLVKTLRWRADFKIDDVVKEQYDEKIFGPVGRVFGKDKEERPVTYNLYGTSKEAFSDVDRFIRWRIAFMEKSINLLDFENIDQMVQVHDYEGVSLRRTPSEKAAAAQATAIFQDYYPEFLSRKFFVNIPALLTWIFWLFKPLISAATLAKFTPVGTGAQTIGAALLPYIDATELPKRYGGEASDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP30</accession>
    <name>A0A401GP30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endoplasmic reticulum vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0510210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614875.1">
        <property type="nucleotide sequence ID" value="XM_027759074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP30"/>
    <dbReference type="FunCoup" id="A0A401GP30">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GP30"/>
    <dbReference type="GeneID" id="38780879"/>
    <dbReference type="InParanoid" id="A0A401GP30"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019579805" evidence="9">
        <location>
            <begin position="30"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="29"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="225" mass="25460" checksum="6442ADC58C491C66" modified="2019-05-08" version="1">MHLSLLQRSAALRYLLFTALLLLCQPVHAIKFTLDAHRYPPAKCVWNAAHPGALVIVTANIGPGEYQRIDIEILDSGPQRNVYLSKKAVSGEKRFAITAHSEEDVGVCFRNYLDPGVPIEAKSRSRIIDLDVDIGADAVDYNAIANQESLSGLETEMRKLEGVVKEIVDEMEYLKKREERFQTTNISTNTRVQSFAWLTILSLVGLGLWQIFHLRAFFKRKYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP93</accession>
    <name>A0A401GP93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614974.1">
        <property type="nucleotide sequence ID" value="XM_027759173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP93"/>
    <dbReference type="FunCoup" id="A0A401GP93">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GP93"/>
    <dbReference type="GeneID" id="38780978"/>
    <dbReference type="InParanoid" id="A0A401GP93"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46161" checksum="1CD7342C05915D4F" modified="2019-05-08" version="1">MRIFSAPTSQLPPIGKVRQYSVEDLAKALRYLRNIYNPEVRGTRRVDTKERLSSPAALDGHSSYLSSQTFLDAMRSDAFERSHAIRWLTTVVSQAYHFSDSSDADSANAAAQEILLQDAASLLAVCAGPASAGILSRTFRFLSEGGDISVQLTDIPLQNQDYSSVGAQTWGGSCLLAEMLAASPEKFILPMVRDGDIAYWRALELGAGTGLASITLAKILERRADNFDAHPATVVASDFHPSVLANLENNIKANLLPPVPNHTRLSISTHFLDWSHFMQHKPRTHPFDEPFDLILGADIVYEVEHANWIKACVEQLLRKPGLAGTQIPSAHFHLVIPLRPTHLLECRMVEEVFNFGDAERSDLTPSVPHPSHSLCIMSKDIITCEAHGDVRARGDARAAEVEYVHYVIGWCVIGSQICM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPK4</accession>
    <name>A0A401GPK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615061.1">
        <property type="nucleotide sequence ID" value="XM_027759260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPK4"/>
    <dbReference type="GeneID" id="38781065"/>
    <dbReference type="InParanoid" id="A0A401GPK4"/>
    <dbReference type="OrthoDB" id="3058546at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="201" mass="23191" checksum="C000634945B34160" modified="2019-05-08" version="1">MLPSSVRTALDLQKALSMAPFRLQQIGDCKTRVHLFEERYTYVDEDDSYRDMDENEDERASTQPKKVSGPNESCIKELCEIYKEHGSDSWSDTLDASFKLTVTRPGCEFSGELVPKSEEEDKEAIADRLKKWYEHGENVRDAREILASEFTVSDGLVEEIKKHWGEHFIPSAVRVEPYKIHIYGPGGMFQFHRDTPERDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPT8</accession>
    <name>A0A401GPT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0601470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615082.1">
        <property type="nucleotide sequence ID" value="XM_027759281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPT8"/>
    <dbReference type="GeneID" id="38781086"/>
    <dbReference type="InParanoid" id="A0A401GPT8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="64" mass="6728" checksum="912DDA2CA3A4683A" modified="2019-05-08" version="1">MKMMAWLFDLSAERPGPLGIGAGYGTLNENVKGFARSSPTLVSEICSKVGPDLGRKLQSASGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ99</accession>
    <name>A0A401GQ99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615310.1">
        <property type="nucleotide sequence ID" value="XM_027759509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ99"/>
    <dbReference type="STRING" id="139825.A0A401GQ99"/>
    <dbReference type="GeneID" id="38781314"/>
    <dbReference type="InParanoid" id="A0A401GQ99"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="106" mass="11515" checksum="00DE315ED567E813" modified="2019-05-08" version="1">MSPSTESESSGKQSSTQKSPSGGKREEASFHILPHPATNDPRDLEGPQLGGGLNSNPEIGAFHAREPYVPSPALMQNVEQPKTREELRARAAELNQKSQKHTENRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQT7</accession>
    <name>A0A401GQT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0605090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615443.1">
        <property type="nucleotide sequence ID" value="XM_027759642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQT7"/>
    <dbReference type="GeneID" id="38781447"/>
    <dbReference type="InParanoid" id="A0A401GQT7"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="82" mass="8601" checksum="CFFED6A73B3314AB" modified="2019-05-08" version="1">MRAIKERLCGHGRGTAAAAGAETGGRILQNGSIAVFIGAPVPPHYVAAKTAIDSEGFTKSLVARLDPEWDIKVESLCNVLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRE0</accession>
    <name>A0A401GRE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0607650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615698.1">
        <property type="nucleotide sequence ID" value="XM_027759897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRE0"/>
    <dbReference type="GeneID" id="38781702"/>
    <dbReference type="InParanoid" id="A0A401GRE0"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="187" mass="20755" checksum="F37D24B6EE4D7180" modified="2019-05-08" version="1">MVNWACSVIADLIVLFVTWSSTYKIKRDADRVKMKAPLATLLLRDGTVYFLLFFISDIITLVASLNDTFYYVDCLTWPASSMVLSSFILNLREIYMSDTSGPYSRPSFDVSRASDLRLASRIVGNIGAPLSLSVASPVDGDNVAEHDLPGDGLEDEDGDELSDDEIQEVPRVAHNPLAADFVEEEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRI4</accession>
    <name>A0A401GRI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615247.1">
        <property type="nucleotide sequence ID" value="XM_027759446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRI4"/>
    <dbReference type="GeneID" id="38781251"/>
    <dbReference type="InParanoid" id="A0A401GRI4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="241" mass="26220" checksum="19BA1301BEC234AE" modified="2019-05-08" version="1">MSIHFDSEASTPMARCMLVDETLDVEPVPKLLDFDNSPPAMPGRQRALVIDSPGATPVHSQVRWLNSPSALPPKRRPLLDDVLSSPPLPSAPSHSPARTFNDSNFRHDAPVIHYMKGSIEPVTVTSRMPSLAALLDELPIHHPTHWEQVPGLFPDTTQLLPMAVPGETNAASGSQVACLSRSFAQIAAEADSSMDDDEGDSFARELNLTEDMHVANLNASSTVLQMGYILRDIHGEAYRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRW0</accession>
    <name>A0A401GRW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0700700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615803.1">
        <property type="nucleotide sequence ID" value="XM_027760002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRW0"/>
    <dbReference type="FunCoup" id="A0A401GRW0">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRW0"/>
    <dbReference type="GeneID" id="38781807"/>
    <dbReference type="InParanoid" id="A0A401GRW0"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="132" mass="14335" checksum="FE8F21EC98425649" modified="2019-05-08" version="1">MLPAKRNKVDISKLTEEEQKLFRLYGKLPTHKNVLTKMQKDRKYFDSGDYALSKAGVAPQNTVGTAIPNPENIPHASSPHVAHQSLSVSPTNSSPVKESPLAELEDTKTTSEDVDEAAPAEPASEPEATEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRZ8</accession>
    <name>A0A401GRZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0701800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615908.1">
        <property type="nucleotide sequence ID" value="XM_027760107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRZ8"/>
    <dbReference type="FunCoup" id="A0A401GRZ8">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRZ8"/>
    <dbReference type="GeneID" id="38781912"/>
    <dbReference type="InParanoid" id="A0A401GRZ8"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="299" mass="32254" checksum="2FEB42075B883FDE" modified="2019-05-08" version="1">MAEPRIAFKAGRAFRREGTNLVDADSTKGAIILQNGDDGLLHFIWKNRTSNEVEEDLILFPTDASFVKVEQSAWGRTYVLKFASSNQRHFFWMQNADPSRDTEFVSNVNRLLTDPQTIPIWWAPGYNPAENSQASTSTAAAAAGPSQPGTSSPGAAGFQPTPEQLAQIQSIVASMNTSATAPAPPQPDLSLTDILTPATLTPLFTSHPELIPALFPHLPADLPTPPSQAALQQIIASPQFRAAVRNFDQALRTGLLGGLVRGLGLPEEAGMGIEPFLRAIQEQARTEGGREGNDRMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS65</accession>
    <name>A0A401GS65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0702290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615956.1">
        <property type="nucleotide sequence ID" value="XM_027760155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS65"/>
    <dbReference type="GeneID" id="38781960"/>
    <dbReference type="InParanoid" id="A0A401GS65"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8597" checksum="AD884E64297DB500" modified="2019-05-08" version="1">MFPHLFSGMRRTSISTIAIRPAMQDRRAVDVALYPGLPVCMDLFNDDGIDRRPASEVWSPFALVPPRPSLPYDDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSL7</accession>
    <name>A0A401GSL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615647.1">
        <property type="nucleotide sequence ID" value="XM_027759846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSL7"/>
    <dbReference type="STRING" id="139825.A0A401GSL7"/>
    <dbReference type="GeneID" id="38781651"/>
    <dbReference type="InParanoid" id="A0A401GSL7"/>
    <dbReference type="OrthoDB" id="3070852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12886" checksum="C6E470800303EA0C" modified="2019-05-08" version="1">MSNDLASEPPSSVVSFGSYADLHTSASSSTSCSSVDFGYNPFTSYGLLLGSGNQVWHPPMLPPDQSPRFIHLPMLPPDQSPCFIHPPMLLPDESSDMFLHPPMLHQDNTDTIRAQLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT30</accession>
    <name>A0A401GT30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616280.1">
        <property type="nucleotide sequence ID" value="XM_027760479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT30"/>
    <dbReference type="STRING" id="139825.A0A401GT30"/>
    <dbReference type="GeneID" id="38782284"/>
    <dbReference type="InParanoid" id="A0A401GT30"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41413" checksum="C031E940ACD32DD0" modified="2019-05-08" version="1">MIPGLPTELTDRIIDFLWDDAPSLCRCALTCHTWLPRSHYNLYNSIHLDTRRSLESLIRASRIRNVERSLSSVHRLELQDTKPGWVHRLPLVLGHILSDIQELLIEHLDWNGICMHPDTVPFGFMQFGRVTTLSLSGCTFRSPRQFQCLVSALTRLNILKISATVSSAKTAVADTAPAPLRLPPLIEVSMDPNVDQPLVQSLLEWFACASLKPALRKFQLYSSRNVTPQVRKFLEVVGGVLEDLTLFLDQSFSTSDLEQLNVRSCVSLRTLGLRGSRAIALEHMLGVIAPSSRIHDLWLRVNTMESSPNLLSIFEEARFAELQRFTISTFPQEANASVTEAVEALCNRGVCADVSFEYPYVYPRPGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU91</accession>
    <name>A0A401GU91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription and mRNA export factor SUS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SUS1</name>
        <name evidence="2" type="ORF">SCP_0802710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ENY2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU91"/>
    <dbReference type="STRING" id="139825.A0A401GU91"/>
    <dbReference type="InParanoid" id="A0A401GU91"/>
    <dbReference type="OrthoDB" id="6221744at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03046">
        <property type="entry name" value="ENY2_Sus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018783">
        <property type="entry name" value="TF_ENY2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038212">
        <property type="entry name" value="TF_EnY2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12514">
        <property type="entry name" value="ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10163">
        <property type="entry name" value="EnY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="11483" checksum="F8491A550572F3D3" modified="2019-05-08" version="1">MAPRGEARNEVLYVQLHRRMVESGEWDRLSAVLMRELNEYGWLDDMRHRSKEMARGMERPTVEQLMAGLRAHAEASVPAGVRQQVVGMLRQYMEKQVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUG9</accession>
    <name>A0A401GUG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0803510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616742.1">
        <property type="nucleotide sequence ID" value="XM_027760941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUG9"/>
    <dbReference type="GeneID" id="38782746"/>
    <dbReference type="InParanoid" id="A0A401GUG9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="375" mass="40055" checksum="FF9BD09DD2673978" modified="2019-05-08" version="1">MGKSNDSTRKAASSTHQNQGADTEFSNEALPPMTSCSDPTLLPPPERNDATTSHREGGQPREDTAMIGRNEGVFSYPAMNTSVLASSSSSVETLKALNSAKTPLRTATSSNALSTAALVTPSTPTSSALPAYSSTIAHPASTSNQTSSPNPRPKFIHIPGETKEEKTELIRRGGAAFSRSIRSGQQRTHRSGVPPFPLRTIAHDTLVDRAWLYSVQRLEATRAYSDVVIEAMVVPSPRPKIPVMPPQPRMPRKSTQLEKKPTPRVVPVSDVKYNTFGAGEDGTQGHQFVDGSATPAVGRNAEPLILPDKGKGVSRGEDAGESRVDSGPPSHSLTFNLTTPTGEGREKGKKRARDPEDDDSLAGAQHGQARPRLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV22</accession>
    <name>A0A401GV22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0801010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616497.1">
        <property type="nucleotide sequence ID" value="XM_027760696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV22"/>
    <dbReference type="STRING" id="139825.A0A401GV22"/>
    <dbReference type="GeneID" id="38782501"/>
    <dbReference type="InParanoid" id="A0A401GV22"/>
    <dbReference type="OrthoDB" id="2796020at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF25">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="184"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE85584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="433" mass="48772" checksum="4708EB795DF31323" modified="2019-05-08" version="1">MGPTAPYSPSQNGVSERLNRTLLGLARAMIYARDLPRYLWAEVIAHAVYIKNRSPTQALNGATPKEKWNGTKPNISYLQEFGSPVWVLTEDATLSKLAPRANKYIFVGYMDGPKAIKYYDAHTCQIKISRNFQFSSNSPDHLPGNAPHVPQEQIGSNVPILTAQCEGEQNIFLGTLPSNASDVLHAERRPEVPNLTTTADVRREGELGTSAPQSPAKNPRKHRQDDDPDQREESGTDAPSQPRRTRRKTVQHDYHLMHDPEADEDLDNDPDKSNAELVYIAMSAHGNADTDEPKTLSDAKRSLEWPKWEQAVQMELNQLQGMETWELVEPSEDRKPVGNKWVLVKKTNKEGEIIKYKARLVAKGYSQIPGMDYTETFAPVVRLKTIRAILGLAAILDWEIGQMDVKDTYLNGTLKEEVYMPWNNLRANCRCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVK6</accession>
    <name>A0A401GVK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617171.1">
        <property type="nucleotide sequence ID" value="XM_027761370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVK6"/>
    <dbReference type="GeneID" id="38783175"/>
    <dbReference type="InParanoid" id="A0A401GVK6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="73" mass="7751" checksum="E0FCD91DD7912E35" modified="2019-05-08" version="1">MINSDAGTQNSFSPRRTPLGHAVPLLAFGLSHLSHCTSAVSAPLNDLCVLPGREPIAPTILAGEILMRSIIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVR8</accession>
    <name>A0A401GVR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0803760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616767.1">
        <property type="nucleotide sequence ID" value="XM_027760966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVR8"/>
    <dbReference type="STRING" id="139825.A0A401GVR8"/>
    <dbReference type="GeneID" id="38782771"/>
    <dbReference type="InParanoid" id="A0A401GVR8"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="288" mass="32918" checksum="52A18D3C3D73C2AD" modified="2019-05-08" version="1">MHYTDIFKRFGPAYSWWLFAFEHCNGEQEQVKLNGHAEGEMEVTMMRNWVAKHRLHELMLSLPNDVSPEERKLIQRACSDKGATRGTLRTQIAGFTSGCTILKPKSAKKFTDLRTFPHPTVYSMLLEYTRKTWPELNIEDDFTTDRNAILFLAARSSKALPFICKDGIHYSSSMDHRSQADRFACIDMDGSRVPCRLIYHFEITISDKPPIVCSIVQRMVSDDDIPTFPWSIYSTDLGVYVAYADRLQDMEVIATDQLAAAVAIIPITSKRLGNEVPLWVVHSFDRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVZ0</accession>
    <name>A0A401GVZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0902770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617311.1">
        <property type="nucleotide sequence ID" value="XM_027761510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVZ0"/>
    <dbReference type="GeneID" id="38783315"/>
    <dbReference type="InParanoid" id="A0A401GVZ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="216" mass="23135" checksum="755F77B8E43F434C" modified="2019-05-08" version="1">MQICNSQTQIQFERAGIVLDDDASAPSPHPTHARALNPQYCPIPLASPIAVAAAESNTSTASALSPPFLRRTLSKIERCRADVGAHSPSPQADATYARALNPQYCPNSLAFPIVVAQHSQPPPPSSIFRPSWTVCAVHARADAESAEPKPGHPAFLESPNANPLGPQRARPLELGSAQKRLARRPAARHRRVGVAFGVRRLSTKLTGRKFVRGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXK4</accession>
    <name>A0A401GXK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anti-silencing function protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1001850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617854.1">
        <property type="nucleotide sequence ID" value="XM_027762053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXK4"/>
    <dbReference type="FunCoup" id="A0A401GXK4">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXK4"/>
    <dbReference type="GeneID" id="38783858"/>
    <dbReference type="InParanoid" id="A0A401GXK4"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="190" mass="21249" checksum="F38D273748EFCFED" modified="2019-05-08" version="1">MSIVTIRNVEFLNNPARFLDPYHFRVTFECIAPLPDDLEWRLIYVSSPGNEELDQELDDCLVGPVPAGVNAFEFEGSPPSPSKIPPEDVLGVAALILTGSYKEQEFVRVGYYQNTEYDNEEMKEALPEPIRFDRLVRDINTKPRVTRFQIKWDISPQQPPQAVSVGAATSAEVPSANDIEEGEDSDGMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXV4</accession>
    <name>A0A401GXV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 100 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1002800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617946.1">
        <property type="nucleotide sequence ID" value="XM_027762145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXV4"/>
    <dbReference type="FunCoup" id="A0A401GXV4">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXV4"/>
    <dbReference type="GeneID" id="38783950"/>
    <dbReference type="InParanoid" id="A0A401GXV4"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019585232" evidence="3">
        <location>
            <begin position="24"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="910" mass="102006" checksum="A70AAB1862FB92C6" modified="2019-05-08" version="1">MSSLRQHRVIIASLFLPTTAVLGDSAPSSPLVSTPGDAPSFPSAPPPVRPFLNKATGPLKSIVEDLKDKSRQATPAATPRVESSNPFTSFPGLDVPENGTSANGVNGNHVRPHQITHPNSTASQPRVQRRLSRSSSHRTPTRSLSNHSHDLSQGWHLESNPHCNGGLKNAVGSMGVRMQRKLWVGTLGINTDRFRESLRRSMEWRMRDDSDSTPVWIPDAEFASCYDEFCHQVLWPCLHYAIPDAPKTKSFYESASYKQYVAVNQRFADTIAAAYTDGDIIWVNDYHLMLLPAMLRARLPGAPIGFFMHVAFPSSEIFRCLSMREELLRGLLGADLIGFQTANFARHFRQTVSRILAAEALPKGVQMEDRFVDVGVFPMGIDVSSLTEKKHDPEVAEWVKLLKQRYAGMKLIVGRDKLDEIQGVRHKMQAFEAFLDKYPDYQGKVVMIQVALQTTEENEAQGGVTDMVSHLNSRFSTLTYQPVVFLHTQDLTFTQYLALLTVADAFMVTSLREGMALRTHEYVECQEERHRPLILSEFTGSYSYSGFRSCIPINPWDKRMTANAIYQALTMSDDEATSRWEDMHNHVVTQSAQTFVTSFLLRCLRASIEHLRGDTVDVAELDVARILPRYRHSQKRLLLIDFEGTIWQRDMRSIISGAFDPPADAIRLLNRLAEDSRNEVWLLSGLQVKGVLEVAAKAAPQVGIVAENGCFIKMRPGRNGESSWINMVVNFNLTWKAPCLEILNYFTERTPGSFIEEREASIVWRFWTEPDHLSDRQWARRQAAEAQNHIFDSLGERYGLRIIPGANSFLVLPNNISRSTAVGAILQPGGPAHAAPAPRPSWMTSETSETAGAGDVDFVLAVGKDEKLMRRLNELDCAETVSTGRRGTDAKWKLDPDNAVPALWRFAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXY3</accession>
    <name>A0A401GXY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1003320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617998.1">
        <property type="nucleotide sequence ID" value="XM_027762197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXY3"/>
    <dbReference type="STRING" id="139825.A0A401GXY3"/>
    <dbReference type="GeneID" id="38784002"/>
    <dbReference type="InParanoid" id="A0A401GXY3"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="103"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="317" mass="36015" checksum="DB2139C12E8EC728" modified="2019-05-08" version="1">MSDIFRSLEDVSNPENVPTPRPSTTALPEVERTQTRRRTADEEFSPLTPLRTYELNEKLMSESIPLRPLIAPIESMLELRAEYEGGSQEFVQQIDWLVANGWKGVRRARGDGDCFYRSLAFAYVERILQNPEPVMGVTSAISLLEVSQPMLEVAGFEPVVFEDFYEVFVSIINRIIIPGPDGELLTPITLLEAFNNDEVSNSIVAYLRLLTSAQIREDPESYAAFLFHPESGESMDVRSFCENFVESVGKEADHVQITALSRVMKVNIDVAYLDGHTAEKVDFVHFHNTDYSGLEPIILLYRPGHYDILDQREYEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXZ1</accession>
    <name>A0A401GXZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1002970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617963.1">
        <property type="nucleotide sequence ID" value="XM_027762162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXZ1"/>
    <dbReference type="STRING" id="139825.A0A401GXZ1"/>
    <dbReference type="GeneID" id="38783967"/>
    <dbReference type="InParanoid" id="A0A401GXZ1"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="549" mass="61221" checksum="A5ABC74D0477F816" modified="2019-05-08" version="1">MQGPFTLPEVTLSDTVFALCGSAVVVYLIFKRYEPINFFVHLPLLTIPPTLALPLLLQLLAPLQAVFISFSVYYATIVLSVVLYRLSPFHPLAQYPGPFLLKVSKCVMGWFAFQGRTHTYVHELHQLYGDIVRIGPNEVSIRDTTAIIPLMGSLGLPRGSNWRARGMYPSIPSLVSITNHAEHAERRKPWNRAFNSAALKGYEDIIARRATQLVENIARRGKVDLGTWFSWFSFDFMSDMAFGGGSEMMRDGDNASIWSQLESALKWAALLGHIPWLGAYARSVPGIGEGLKRIDAFGTQRATLRVKNGSLSRDLFHHLNGEDGKAGTQPPLELVVADGTLAVIAGSDTTTGVLTNLFFCLLRHPESYVRLQAEVDKFCPLGENALNTKHLGDMVYLNAVLNEALRLYPAGPSGSQRTTGKGHGGKFVGPYYLPEETNASIHTWSVHRDARNFSMPDKFWPERWLIAEDLVLQAQTPGLGLTRRHTTTASGRLWFARRGSCRCWWSVDLASECSGHVWFSSQISSDLGVRYLIMLASRIPPSWWNEAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY64</accession>
    <name>A0A401GY64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1003460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618012.1">
        <property type="nucleotide sequence ID" value="XM_027762211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY64"/>
    <dbReference type="STRING" id="139825.A0A401GY64"/>
    <dbReference type="GeneID" id="38784016"/>
    <dbReference type="InParanoid" id="A0A401GY64"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="12421" checksum="BE962B8E1EAED173" modified="2019-05-08" version="1">MIRNTTKYGQQLHRIAAAWPGDPFRPNIQLKTFLQSLSDHPNLTPQAVEAARELQDNVYQKRFSLSEKMLQPASMPHHYTRLLEAFDKSAKGIRRPWWKIFFNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY99</accession>
    <name>A0A401GY99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1004520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618118.1">
        <property type="nucleotide sequence ID" value="XM_027762317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY99"/>
    <dbReference type="STRING" id="139825.A0A401GY99"/>
    <dbReference type="GeneID" id="38784122"/>
    <dbReference type="InParanoid" id="A0A401GY99"/>
    <dbReference type="OrthoDB" id="3214861at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="188" mass="21292" checksum="5344E2B212923CBC" modified="2019-05-08" version="1">MANDLNATVGALLLGTLFTAVGFGITTMQTYMYMSRFPNDPKIIRWTVWTLLVLDVTHVALTWHMIYWYLILNYNNPASLDLSVWSFDITVVITAVVTVVAHCFYARRVYILGNRQWIIAALILILSAMRLIFGSYVTARIFQIKLLKELWGKIGVEVGVGMGAGTAADLLITISLVWYLRKHRGFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYR3</accession>
    <name>A0A401GYR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">SCP_1005550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYR3"/>
    <dbReference type="FunCoup" id="A0A401GYR3">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYR3"/>
    <dbReference type="InParanoid" id="A0A401GYR3"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000032">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="13"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="204"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="66"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="379"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="413"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="509"/>
            <end position="510"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="518"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE87307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="593" mass="66752" checksum="8F14D4107D14EB0C" modified="2019-05-08" version="1">MSSSPHDRLPRSLTILYATETGNAQEISDRVARQCRRIHLDAIVHSMNAYAPSDLISENRVVFVVSTTGTGKEPRAMTPLWNMLLRADLPEDLFEDLAFAVFGLGDSAYEKFCWPAKLLARRLESLGATEICARGEGDDQHPLGVDGAFEPWIAKLEDVLLAMYPLPPDVVIPPADSLPPPRISLSDADGPSSSALKDPLALDRRYNTATMSCNRRITAEDWYQDVRHFEFDFEEDVRYEPGDVLVIHPEAAAMDVDTVLVTLGFANVADDPFTITHALLDQSLPDHLPHRTTLRALFTRYLDIGAVPRRSFFALLRHFVTDELEREKLEEFLSAEGADEMYEYCQRPRRTIREVLDEFRSARVPREYVFDLFPPLRSREFSIASSVKRHPRQVHLCVAIVHYRTMLKVPRRGVCTSYLARLRVGDTLRVGIQKGLLALPEDARTPVICVGPGTGVAPMRALIEERVFAGSTENTLYFGCRSAKKDQHYHRELEAHAQQGELTYRVACSRDGPPGVARTYVQDLIREDALRVWGLLVRGAWVYISGSSNKMPAGVRGALRDVVRMEGGKGEEEAREYVGAMEREGRLIEECWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ61</accession>
    <name>A0A401GZ61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618352.1">
        <property type="nucleotide sequence ID" value="XM_027762551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38784356"/>
    <dbReference type="InParanoid" id="A0A401GZ61"/>
    <dbReference type="OrthoDB" id="3251015at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2001" mass="223405" checksum="52895DAFDF33B16D" modified="2019-05-08" version="1">MEVDEPVTPKRSRSFQRRVAEGPATPFSPIPSPTVVLASGNELIVRGVWDQSKPLIDPVPVVERLISDIAQSIPDLADVHVVIKPFLSGNRANPTTSCYIRLHPSLEPLTPDDEPRFDLLGSITKETPLDKTILEKLRSHIEHQGFRVVDSFSNSSGPILILADPSHVDQILDQRKLTITSVSPNELTVLPGCQIEILHAFELVIMGISDFEGISSHVLRWINATFIDGNDRLLVGHRIPPGEPDALVFWMSDWKLTSKVLQAAKMFSEQFKQYKLMPPQLLWQANTHGTWHINFTQTFTAGAESMNSGLAALTHRVDQMQRETRAQNDAVQLQLSGVTASLTTITSHVGLIVDQLGNQQRALLIAIPPTPSTPGTPSPSPRPSRGLTSNSTIIIPPALRTSTRRSSSILEDPLTLRLPSSSVPLSRGTSTDALGRSSAKKPRTSKSSPVNEGGTSQSDQVRDYGSGSMSLPLNAARGISSDFVLKSKPLHSCMPAHRKIGCTCFLVVEALREAVGNVTGRVFACPLARSQSIVIKLVLSTHFPLLFILLVVLTLVNLSNAVPTAPPSTQPLSIFALNANGLVHAGKVHHVNTAINARQPHVFVLSETKTATKLSSTLLDHDYAIFEEPGVAQSNSHHYKWGVVVGVRKDLQVSQRHVVTHRALRGRIVAVDIVLSTNSGCGYDTAFNKPHIKYPNKNEKHRFQWFRDRVDSQVADNATSHLPVMDNESYLSRYNLLTQIILTSAEECFGRVKRFRKQHALITSPSIESLTASIRHLGGAIRIARSAGQPVTVSFTAQQAFNWYIGRYHAEPLTLPFVDFLIKSRRALYKNLFAERMAEITRRARLTNKNRITAALLGRSTKHFVTPASYIPMPLAVNDLTDPAHLITDPDAVKETTRQYFSKLYHHDPPPDIPKPWMTTRSVKEVCEHVHADPFQWPQPASIVAFRAMLRKGNARPSPGPDEWEKWCVKSLSDNTLSLVLDLHNYMVMHAHFPGDLKDMWITMFHKRGIRTDLTNWCGLFLSNFLANSPLSWLNHCLMPYSARLGIIPETQVATQPGVQMHDLMSFLAGLKCWSSRHHQPIYTLKRDQMKGFDYLSPQGFYDAITAYGLPQAIIDLDRASQTDTRCFIRTAHGTTEPIIVTGVTKQGGSLSPVKSTYTTSLGHRYLNDIASQDPNTVIVSTSSAERGDPHLPEDHTHLSIVMVEATDDSYIFTKTLKSLRNNTLHMERFQFAYGWLTQWTKTIAYLLGTTGVQPPTLSFPSITNLPGVDPLTVTEHTVPLVLNSLDFLRTNVDDPTAWFEELREYIDTFTFPTLIGRPPITLLRKIISQSVISRCRALLSLQPVKLADAEILDNCLMTKVHAVLGLPFRFNTHIATLPIALHGMEFSSISRINSAAAVKGLARDLNHHVPAYRNMARVTMADWTCDKNGCVYPLDGTGLSKDFSHYAKSIPSTWITAQKVMSTMTPKLSLRMTDRSDIGSGDIFLSHVIAICNHHIPKCAGDPDGHTLRSLRGKHIRTLSDMGTWRLSADKRLSFHCLPPPTDTAWSLTAQQNWQRISTRLASIDITWMLSGPIDLLLSRSDHQRAAKDQIVHMANVCGFLPSPTSGGRQLWGSDGSMLPASAGLGENRSVTASATGPSMLVVKLKGRNVNILHGELMGLIMGLCLADISLEIPYLHSDHMNLTRLIDDSKTAVNQEARLRNINGRSYYRWILFLIQRKHMQVLYTPGHSSEQSVPAALNHEADHYASRSQNYIHDIAYAPIPTFSMNTFTYYTDDDRWIESNIRVFINHFLAMNTAASLSLGNWQRMAAHLYDSHPPPAYPYTHATAAYSIIIQLYARSGQLPTADLLNNHEKMLSNVCCFGCDAIEDAYHIFVRCPRFESWREETSQALVARTEMKLDEQETETDDQKAILHAAKSLFKDTPVIWPLYYTFYFLGHIPNLEPLLPDPPKDRDGRMRRRKLLHHLSADWHLVAIRLAGRIFGDVQWEMAKRNELLWGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ98</accession>
    <name>A0A401GZ98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618419.1">
        <property type="nucleotide sequence ID" value="XM_027762618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ98"/>
    <dbReference type="STRING" id="139825.A0A401GZ98"/>
    <dbReference type="GeneID" id="38784423"/>
    <dbReference type="InParanoid" id="A0A401GZ98"/>
    <dbReference type="OrthoDB" id="5303367at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="102"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="602" mass="68153" checksum="AA12DB5B30B1C391" modified="2019-05-08" version="1">MGKCRAGGPRVDATLLLHLLGRIDLTRITTIDILIRLDGYAPPVLVAGDSAGMQRDASARDFERPPTSSHDSQRRRILPDGWDRLYSSSQTSQVATDKGVVSSAHFSAFIRAAVEKNNNALTEKVAVWQDQHCINQADGREKNAQVAIMQRIYFAAQCTMIMLDDVEFSADEFNTLKQSKTTDVHLALVRRLLRARWFTRAWCSQESVLSRRAIVCVHQTGRPDSPLLFNVDYIWQWLDVARRRDGTLPFFSEPRGSITDAAWTRMAKTSAWALGIVYEMGCYNHYDKVPLTNNLLRRIYTFDDPPEAFGVNEPCILENVLKMVNVMAIDQRDFSLLLANSVQQNPLRGKRGFGWAGYPVRGDRIAEMWHPKDYEVARDPDIAVDATGLTARGIMAKIVLQHVWKLQRDSGGLHVSVDGVHKLVTSDWPMHDVFRSSRPHQLLRDFLYALEAFDDRGDPEAEVYSRAVYAYLLEEDYNYQPGPFRGDMKENMIQTFGMPSPKQRHVADALNFIQRDEGAAFSTVLLDEGTVLLVSGNVENMRNSRIFQPHVVRPKLFSYPLVITVNSMVLDNGNPHQCRGFRSPYQDNIRGSGVDESVFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZD5</accession>
    <name>A0A401GZD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618425.1">
        <property type="nucleotide sequence ID" value="XM_027762624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZD5"/>
    <dbReference type="STRING" id="139825.A0A401GZD5"/>
    <dbReference type="GeneID" id="38784429"/>
    <dbReference type="InParanoid" id="A0A401GZD5"/>
    <dbReference type="OrthoDB" id="2369050at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="294" mass="32213" checksum="27BAF71B63F28A21" modified="2019-05-08" version="1">MYPLSEPSRCENTASATAKYVPTKGGSTSGQSTGKCPPLKDTERQFLYDNEGCLKCHRLFAGHISRDCPNGFPDLSTYKMITQKFINKLKGQHKLTRTTAAVSAATVESDEERENSFLHPVVTVMSSSRMLIVAMPNNDSSILSEEGNSESSVSPLLSAVTPITMCTAVRSHLPTPVDAPFRVPYLVWHYTASGPAHSLPVTFDALIDDGSHTVLICDDYVDHLQLRHRRLPIPELIELAMEGNGQKTVIELSEWVHLSVFDPISSWSAKSVRALVAPGLCVPVILSLPFLVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZJ1</accession>
    <name>A0A401GZJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1102640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618500.1">
        <property type="nucleotide sequence ID" value="XM_027762699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZJ1"/>
    <dbReference type="GeneID" id="38784504"/>
    <dbReference type="InParanoid" id="A0A401GZJ1"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="597" mass="69966" checksum="CA9C196A9CE1B601" modified="2019-05-08" version="1">MWNTGPHKQWNYHSPYPKSKKTVRERRPRLFRHVRMPNQASASPGLPSDRAPIFTAFPASPSHPKTNFNDPSTPTPKPIYITPRKVNRPGPVPKTDGPSLFPKSVFNEPPATPHTPVGPSPTAIYFAKKEPMFATPPAIPFPFPRTMRTKQQPPAANPLAGTARPRTGPQRVREQERDARRLRRGVVHHRNPIVVQAEAAANVNALLEANPLAQQMLAAGALDKEDRMLLQQLSHLTIQKAIRSQVDAGREEVERAAADMRGHVEKIEKHDKQAQVLWEEAARRAEEEKARLAKEEMIRRAEEEKAEREELLRQATPVWAEIPLFKLQYAQLERERTELMEAELRRKAEADEKQRRERERVEEMLKDIRRRRQEDEENKRLQRERREWEHQEHLRFMREQAERLAHLRKEMDQRQRDQEALRWQEAEAQRQKEAARQRQEETRRRLLEEAQRQKDAARRHQEEIRRRGEEAKAKEGGRAANAFKLYEERWAMLKQQDFKMNGPIRFFEMPWPVFVPIVSPADVTEERVREFLFHPLRSSGKTRKETLNSDFLKWHPDKFSVQLPKILEAERSKVAETAEIVARILINIKTEEDNHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZX0</accession>
    <name>A0A401GZX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1103850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618621.1">
        <property type="nucleotide sequence ID" value="XM_027762820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZX0"/>
    <dbReference type="GeneID" id="38784625"/>
    <dbReference type="InParanoid" id="A0A401GZX0"/>
    <dbReference type="OrthoDB" id="2847449at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14233" checksum="E4AEC2A5CED49026" modified="2019-05-08" version="1">MVHIAGAETARAMWEQLRTVKEQHGQHGILALCQRFYRMQAKEEDNISSHITQLRQIQEQLHLMGKVVSDEDFWLILATSLPESWDSFLSSYFGAVGSNVGAEGADNVHPQLTSQELIAIILDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0B2</accession>
    <name>A0A401H0B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1200670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618755.1">
        <property type="nucleotide sequence ID" value="XM_027762954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0B2"/>
    <dbReference type="GeneID" id="38784759"/>
    <dbReference type="InParanoid" id="A0A401H0B2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="96" mass="11212" checksum="842DD3AA0E3C852A" modified="2019-05-08" version="1">MGDPHPLLVHHQNQFLFDLAPLVRTYLQVNPHYRNPPSHTHRLLRVAVIPIVMDVRMNKDHELAEGCATDVEVIIMSGTVPDDDEDYKYFLWDKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0U3</accession>
    <name>A0A401H0U3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618960.1">
        <property type="nucleotide sequence ID" value="XM_027763159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0U3"/>
    <dbReference type="GeneID" id="38784964"/>
    <dbReference type="InParanoid" id="A0A401H0U3"/>
    <dbReference type="OrthoDB" id="3256331at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="12"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="198" mass="22315" checksum="F4E56FB29BC8BDFB" modified="2019-05-08" version="1">MSELTRLTLQPDNPCNTKITDEDGNVLYVVYTEHGKNASTTRVLDPQDHVLAAYVWTDYISSDRVALGDQPLIPLSKWLHKSIIPFVDDVSFKDDKGRKYKWKGNSPGMALQLHTEDDGFKEPIAGFERSRRDPKSDPKNSTWTPAQLLFMPPALEIRDTVILSFLVLERSHRSNEQSKDNLIKGEVALMGGMPLGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1E6</accession>
    <name>A0A401H1E6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1300370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619136.1">
        <property type="nucleotide sequence ID" value="XM_027763335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1E6"/>
    <dbReference type="STRING" id="139825.A0A401H1E6"/>
    <dbReference type="GeneID" id="38785140"/>
    <dbReference type="InParanoid" id="A0A401H1E6"/>
    <dbReference type="OrthoDB" id="2797670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF7">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="29004" checksum="CC92BDE0C5064F94" modified="2019-05-08" version="1">MASLNPHVKLPTLTGDNYYDWKFAVSMVMRHNACWDVVSGKVSKPAEDKLGDWPKKAEDGLTLIGLTVDPSQYGYIRDCVDGPAAWKALAAVYEKNSHTNRIALKRQFYNFVHDPKCPIRDYISGITDLAAKLKGIGVALEDEDVTDVLIFNLHEDYSNIAGTLTATKGDLKIADVTGALVDEEGRRRGLPKADDEKEVENMALFAQKERDNRNRNAECYNCGKRGHIARDCHLPGRYNEKNLAKAEKASVAFDLRDVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1F7</accession>
    <name>A0A401H1F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_1300470</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619146.1">
        <property type="nucleotide sequence ID" value="XM_027763345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1F7"/>
    <dbReference type="STRING" id="139825.A0A401H1F7"/>
    <dbReference type="GeneID" id="38785150"/>
    <dbReference type="InParanoid" id="A0A401H1F7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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        <property type="entry name" value="Chromodomain_CS"/>
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        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
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    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="166"/>
            <end position="326"/>
        </location>
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    <feature type="domain" description="Chromo" evidence="15">
        <location>
            <begin position="465"/>
            <end position="519"/>
        </location>
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            <begin position="1"/>
            <end position="20"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50013"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50994"/>
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    </evidence>
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            <dbReference type="EMBL" id="GBE88233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="519" mass="59542" checksum="632A00216F27F958" modified="2019-05-08" version="1">MIQSDALSRRNGLDDSESDNEDRILLPNALFVRSISPTLFDEIRNHAAKDLIVHEALEAIAHKGPFPMKSSLSDWEVRDGVILYKGKIYIPPSETLRRDLVRLHHDSPAMGHPGKFNTLELLCREFWWPGMYTFVYNYVEGCATCQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLRLYCGNNPETWADRLPDLEFCHNTREHSAQKMSPFRIMMGYEPCGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELAQQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYHENDIHGPNYVNPPPDVIDNEEEYEVEAILNHKTYRGHLRYLVKWKGYSSAENSWEPTHNLQNVKRILDAYKRTRGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Q2</accession>
    <name>A0A401H1Q2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1301820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GBE88367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027763479.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2681654at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="369"/>
            <end position="623"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="635"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="683" mass="77043" checksum="1C1DB6D2FD9178EB" modified="2019-05-08" version="1">MAAPRRAPTPLRSSTSSSPLEAMIASKQAHIEELVTQTRTLEHTISKLRAALGEEQVRAQDAVSALQKRWKAERAEWRDGCETLQAAHRIAHLRTAVELDRERVSVLKEREEVRRERLARLQRDFRLVTFQLRETELEERVATLEAEIGDAERAVERERQKLSDEVDGKAGALEARCEGLAAQLRDSAKDLTDALKEKADVKDAISRLKTEHNALVDSSKKTESTLERTTLHLDGLKSTHAELEKKHGEAEQTVVELRRQLEKWHKLESREGAEMDALRRERMGLVVQVETLQTQVKELEERAEELEGTAETATEKRKQKDEEYREALDEWKIALEEAQEKEEKLEAEAEELRGQLEDAQKKIKALKVHLSTTKTEARQATVELHSTRESSPKAVKKMKQSKRTPPVRELSSTSEKEVDEVEEVVVAPSPSPQPKRNSRSKPRKAQKVDSTSPKLARNLDVDSDEEIQEVEPPKKTKRQPKPQSKNGNGDSRTGKSKTKRKPRKDEDEEEVEVEVEIVEDKRIAGRKGKRKAEVLEEGDVEEPKPARKRNKKKSGDEDEDEDSGTRNKVRPKAKAATAAKPSSKDARRKPPGRAQSKQPRQDDSSDEAVVIGDGTPKNKKRRLNVFPTVAPMKFDWNPLATSEGSLNIPTELSPVKESDAIPPRTSAAFRAVGSMFGSFGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2J9</accession>
    <name>A0A401H2J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1400560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619564.1">
        <property type="nucleotide sequence ID" value="XM_027763763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2J9"/>
    <dbReference type="GeneID" id="38785568"/>
    <dbReference type="InParanoid" id="A0A401H2J9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="311" mass="34636" checksum="CDE328E9FF11FD6B" modified="2019-05-08" version="1">MASSSVLFPKRGDIWLQAVFDKPRIEYPSDFLSFLKATELASGIWQCSHEDSLCNLDACFKHLEPAKNWTCNCFSSTMQLILNAMKDVAKDRLNSIRTRPWQPKQDQSETKPITLGTEMAHMFSSLNHHTQAVAKAELLPWMMSMVLVSHTKQGHVKMVTPVLMNASKALVNNSDTRKENLEVETGVTLVKQIEDTATHLAKLKELKQRTEKEKGAEAPPADSSKEENQQVDVRTSAPPKQLVEVNDTESEPEELELVIPTPLPEIKKQGSSVTAQPTTPLKSGRERAANAPDKPAKRSRKRNGAIMIGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2P4</accession>
    <name>A0A401H2P4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SCP_1400770</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619585.1">
        <property type="nucleotide sequence ID" value="XM_027763784.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2P4"/>
    <dbReference type="GeneID" id="38785589"/>
    <dbReference type="InParanoid" id="A0A401H2P4"/>
    <dbReference type="OrthoDB" id="3261476at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="23" id="KW-0862">Zinc</keyword>
    <keyword evidence="23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="25">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="26">
        <location>
            <begin position="542"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="326"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="784"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="800"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="GBE88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1477" mass="165663" checksum="E212EE0459423795" modified="2019-05-08" version="1">MSSLQQVTSPERQLKRALDSPAEPPTRDRNERRMTQPLERTLVATRALSDSSTFAQSLLGRTRHAYRRSQAARETAVQRRKSVRAVFTTQIRGTFETAHAEPERRRKEDTDHSSHMNLTKLPHKLTPTNYVSWMTTMESTLDTIELFEYATGEVPELDPDVDEALVSQISHLTVVAQVWQEVRRLFAGETLTDWTLLITSLVTTKYADGEDLTLHIAKMKAYRRDLILMSRNIPDDLYACFIRISMPQSWNYVFSGLSQYYTSSEIERCLKEEYAIRQNQQSTARAYNAKQQSGKRLKKEYKPGDPFCKNCERPGHYIKDCWSKGGGAEGKGPRSKKKEKKDLEKQDAKGKERVNEAKEDSDHLSTKSAFVTFTPSSETIGGIRKTGPQLEVHGRGDILILCHVHSGDQHIVTLRNVCYCPDARDNIISESRMDQKGLSIHKQNGLVAVQNSNGKVIMEGARQRDLYELDCAIAPPSSHPSEISFAAQLSPSDSELWHRRLAHIGQGSLQYMVKHALVTGLNLKSIETLGPCDGYAKGKHHQAPFPKQATNRATSILHCLHMDLQGPFDLSITGYRYTLAVVDDYSRKGWKAFLKAKSDATSEIKDLIARLETFSDKKVKIVRSDGGGEFIGNDLQTYFKLKGIKHETSAPHTPPQNGVAERYNQTTHEHALCMLQEANMSSGFWPEAHAYALLVRNRSPTRALVESTPNEKFYGQKPDVSTLRIFGARCHVRVPPESRKKLDAHSLDGIFCSFAPNQKAYKIWIPSRHKFMVSRDVIVYENVPAMPDDDDQNPALSEGVTASKSTQSNSPDKAVGREISATSPPHPPTPQASASPASAPIPTPPENQPSTASAPTPASTPAPAPMPAPAPAHLRRSEHVTRPSWIKQAAEKQQAQEQAMKTHNKAIKEARTLRRQMKVQARTAPEPIPEDATVPTTPEGDVAQVAYMAAFGTDTPMNFCEVTKCSEADNWWTAMHEEIDMLQRRGTWVLEDLPPGRKAIGNRWTYVIKRGPQGEILRYKARLVAQGFSQIPGIDFNDTFSPTVRLKSLRAILHLTAAHGWHRGQDDMTGAFLHSKVDVIIYMQQPVGFDDGTGRVCRLLLSLYGLRQSSHLWNEYMDGQLSTISFHRLICDSAIYVRRTETGANSILAIHVDNTLSFSDSAEELASVRKQLHSIFEMKEEDPNWLMGFELIDNPQEHTVSISHRQYISTILRRFKMEDCVPVPTPMESSLHLSVHDAPSTPEEIAEMKKRPYRELVGALTWISVISRPDVAFVSAHLAQFNANPGKRHWEAAKRVLRYLAGTRDLRLELGTADEEGDTNELVGYTDADWARDVDTRRSVSAYIFQLGNSSIAWSSKRQTTVASSSTESEYMALSYGAKQALWYRRFLTEIGLTLEGTPTALLTDNMAAKDIAKDTRHHGRTKHIDIQHHFIRERIQDGNFNVVHCPTAANIADGLTKPLDKEPFSKMVSDLGLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2V5</accession>
    <name>A0A401H2V5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1401280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619636.1">
        <property type="nucleotide sequence ID" value="XM_027763835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2V5"/>
    <dbReference type="STRING" id="139825.A0A401H2V5"/>
    <dbReference type="GeneID" id="38785640"/>
    <dbReference type="InParanoid" id="A0A401H2V5"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE88723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="236" mass="25937" checksum="8953395D7EAA37E4" modified="2019-05-08" version="1">MATRNRKSDTANGESSGATKELDSQTDLSVEGTIAAALAPSQVERDEVKVNNASATEMKHACDDALKRFLSRPELFKQIYTHTDVRLALGWASVFVAAGTGLYGWKVDFERSKPVVWAGVILYMILTSLQTLYAYFIEGDIVFVGKRKTFDKRIVTERITLTSATKPSTPSTPPAYALTVSYVRSTSGGKSLLGRGRAATERGYNAFFDERGVMDQAAFERWVGQLVGRVMESKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H301</accession>
    <name>A0A401H301_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1402220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619729.1">
        <property type="nucleotide sequence ID" value="XM_027763928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H301"/>
    <dbReference type="STRING" id="139825.A0A401H301"/>
    <dbReference type="GeneID" id="38785733"/>
    <dbReference type="InParanoid" id="A0A401H301"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="324" mass="36384" checksum="C22ABD9AD0DE104C" modified="2019-05-08" version="1">MSIIPAEGSSGWLELPIVQKCGVPSVRDFQLRHGMDLIRGKDLFLVIAPGQGKTTVMHAPLLAAQAQMKIGIALMIVPTKLLALQQETVANSRGIRALAINEDTMREAYHNNRDLLAELVSGEDIRLAIMSPQMLRSKRVRSLLSQQAVKSLVCWFFVDEAHLVDEQSGEWIEIFKSIKTMRAILSARTVWAAFTGMATPSRTLVLAENLGFQPGHYVNARYSVDCSNIKYIPRFFEHAVSGTDFLDISFLIPLEMASPTDITTTLIFCQTIELGYKIMSFLDRLIPEAVPYRNKIIKLYNSLMPATYRQHFVQDRLSGAELHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H320</accession>
    <name>A0A401H320_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1402430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619749.1">
        <property type="nucleotide sequence ID" value="XM_027763948.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401H320">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H320"/>
    <dbReference type="GeneID" id="38785753"/>
    <dbReference type="InParanoid" id="A0A401H320"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="4">
        <location>
            <begin position="937"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="313"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1358" mass="152398" checksum="1E7DADB535A2E560" modified="2019-05-08" version="1">MLPKLSKTSQHPRLFHSTQHKYALRQKQLPKKQNVPPRNPMRPTAAGDPKTQAPVQAREQREEGPISHVKRNELGVQLLSRKLHEQIFRNVSFPAPNKKYVEIAQEHLRMHGLDPSQGVVLPDTSFVLPPLQGRTLDQHFYSIGASAAQPWLRMANELAGAELPPRPEQWDIQAGWTKYEYFSDGSSCSSHVEFPMHEGRPEQMLVFDVETMPEYSPYAVMACAASKNGWYSWISPWLLDQTEEVRNLIPIGDSTVPRVVVGHNVSYDRGRILEEYSIDPTGTRFLDTMALHVAIKGISSHQRPAWNQYRKSREKEQERKEEAVDAVMELMREGEEKMQEEQDSTKKEELQRLLHEMEESLPLLQAVDFLDTEEEEISTKRWEDLTSANSLADVAKLHCGIIMDKEARNDFMKCTPAEILENVQDYLNYCSNDVAVTHAVFSKTLPAFLTACPSPVSFAGILTMGSSLLTVNEEWENYLANAERTYKELEDKVKQRLLDLAHEAKNMMEGERWRDDIWLSQLDWTPKVAGKSRGVLPDESAATASPAETAPVEPTMSEITELVHSDHIPAWYQELLTLGPLDRIVINRILPLLLKLSFDGYTLHRSTTEGWHYVRDGQPMRLPTAKSKVLTVLGGSHGVPNLQSNRLTSIDRDLAMNISTGDTSSDVAKRVLDLAKRTAELEPSQAVQDSWLQQLNWKMMSHSLDPSGQPAAPKKAKLSTKPKPKPKPPPTLWPKWYWDLARPKKDALPGSLDLTVRNRLAPLLLRLSWQGWPLVHSRQHGWTFRVPLSEGFETRTKALEFADSADGTLHDASARGEYVFYKLPHKDGDKANVGNPLGKTFIKYAQDGTLRSPGDEAKDALDMNAQCSYWISARDRVLNQMVVWQDERVNVGVAQPQDPSKKWGIILPQVITMGAVTRRAIEKTWLTASNAKANRVGSELKAMVRAPEGYAIVGADVDSEELWISSVMGDAQFGLHGATAIGWMTLEGTKAAGTDLHSKTASILGISRDQAKVFNYSRIYGAGMRHAQLLLLQSNAGMLPEQAQKLAQNLYASTKGRNTHRPDLFGRKFWYGGSESFVFNKLEEIALSDQPQTPALGCGITYALSKEYLPATFGADYMPSRINWVVQSSGVDYLHLLIVAMEHLITKYNIHARYLISVHDELRYLVKEEDRYRAALALQIANLWTRSLFAFRLGMDDLPQGVAFFSAVDIDKVLRKEVDMPCVTPSQPVPIPPGESLDIAKVLQKTNGGSLWPDGAPMSEDDKITSGGSFVDYRNPDCLKYRADSVAWLQAQATSDFEEIKILAQQYTGQKGRGGKKSKFTNANGLNRLKKVRALGDGDGVDWTNTIEQLLKSLDIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H399</accession>
    <name>A0A401H399_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1403150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619820.1">
        <property type="nucleotide sequence ID" value="XM_027764019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H399"/>
    <dbReference type="STRING" id="139825.A0A401H399"/>
    <dbReference type="GeneID" id="38785824"/>
    <dbReference type="InParanoid" id="A0A401H399"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="229" mass="25984" checksum="B181752920D4D69E" modified="2019-05-08" version="1">MDSMSPDFLAQCIALYKEREREKEKEKAVPTWGELSSLALSDSITDKLGSPHSTTASFHLPVSYLEAKYYYYRLYSKPVLMARTGYWTWIFASIYSDPICLTTFRDSDSKRNLQGTDTWEPPTDPEAYLPCKELRPISSNHPLNAVWDNLAPRILNILDSKGVKWTSMDIVRISFTGEYVAPIVVWIGIKPGTLSGEDGLAAVKECKQVLMANEILDVEVEIHESVRWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3F5</accession>
    <name>A0A401H3F5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1403660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619871.1">
        <property type="nucleotide sequence ID" value="XM_027764070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3F5"/>
    <dbReference type="STRING" id="139825.A0A401H3F5"/>
    <dbReference type="GeneID" id="38785875"/>
    <dbReference type="InParanoid" id="A0A401H3F5"/>
    <dbReference type="OrthoDB" id="669841at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="38015" checksum="3F4EAF10A1BB64DB" modified="2019-05-08" version="1">MDEGRHHASQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDVGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASARDPNAMDVDRVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARMIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3M1</accession>
    <name>A0A401H3M1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619916.1">
        <property type="nucleotide sequence ID" value="XM_027764115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3M1"/>
    <dbReference type="GeneID" id="38785920"/>
    <dbReference type="InParanoid" id="A0A401H3M1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112735" checksum="65C3EC1CC8AF308F" modified="2019-05-08" version="1">MPARFVILTEHQPILSEKLWSYDTADAKGCKTLVQSLRQKLKTQFVDTSNYDDIIVETKIREWLNNHARHAQEKVTKKRMHVSGKPNAFKVWDALERDKVTEAARALAAEKGCNVSKVWRVARSAEWAKLSEEEQKVYEEKAESWRNGTLDDKTKMKLREQRMMQYLKKFAKTMWDTMGIRMAFMLAYPKEAGSLKVEMVEVNHAITNGTPFRAYPGWLRAYQPLAKVFSEWAKGEYGVTETTVTVKKTPADCMRAMDKIRLTANSFPLLPSVPEGMAEAPLKVMKVQVRDFMNHHYALAKGVRNCKSPWTKLNSIDDINEVIPAEMLPENFQWIDPSKMTSVPVRALLDHWRARQEEHGPEQTMRFTQYFDKDGEAAPTKYDPLSPLDGSAQALEEGSEHEVQEALTPKKAGKVKKKGKPVRKVTGKAASKVTKGKAAPGGAKGGGRKRKTKDAYDSEDDARSSQDSDRSSPDIPSMASEEDTASDEDSEDGESVIANKAKGKAVATTNGCKANNGGAPQASGSGGAKTKAKRGLQDLPLGELHRFDTEETDEALSELEPSTKELRLELQGRAPRLTGGSTVGSTVPHLVKRRDVFLATLSVEPRYQDMLKQVKIATVPQVYRFARYDPIPWSEWSYGQRYLPLSFHAVDNFDIVENWLGDKPWLTKYRFLHPQGVQQSALVIGMALRDLTRSQFIEEGEPTNLPDYVVNSAISFDTVEQLLRCCEIITLDMVEGNVTHAMVKPVSKPAIRGAPQGGDGLGGQEEQEGDASARTHDGAATAAKVHKAHQPAPMADKPIIPSGGDEGPSQETSGGASDDGEEDDAHLSVPSSGAERPPPPPFIPKTRKAAATEDRPSGQAKALQGRSITDALQSNIPGRITRSQRQAMDESPAKNTRSQHPLGAVKDLKKLPDPKRKRQPARPEADGEDSSGEDNPPPRKRGRGTRDELVVASPRKKNARAEDSDDGDKPPAKRRRALPQTPEVKDKGETKLKPVRLGKAAAKVKESGQVGAGHKTHSGGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H416</accession>
    <name>A0A401H416_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein YSC84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1500930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620003.1">
        <property type="nucleotide sequence ID" value="XM_027764202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H416"/>
    <dbReference type="FunCoup" id="A0A401H416">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H416"/>
    <dbReference type="GeneID" id="38786007"/>
    <dbReference type="InParanoid" id="A0A401H416"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="453"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE89090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="512" mass="54394" checksum="7EC4C94E91A34C1A" modified="2019-05-08" version="1">MKLNSPLPQTLPKECSKAAKTFKSFVDGGNNGLDGVVPRSVLENAKGFAIFTIVKAGFLFSARGGAGLVIARLEDGSWSAPSAIGTAGVGFGGQAGAEMTDFLIVLNSRAAVRSFMAAGSLTLGGNLSIAVGPLGRNGEAIGSVNTSGKLAAMYSYSKTRGLFGGVSIEGSVILERQDANAQAYHRDASAKSLLSGAIPPPEWAQPLIRTLEACTGMPGRRRWVEELSAQGGEDDYVFGGVGGPYGEVPPSAMSGAGDGGSPRLKKKKERSLGLGWGKRKDSGSSFASEFHDPSRAPVPMDRRDSPPYGSSRAAEDGWSPHRARPATGYFETQFESDYISDERLRRHPHFDSPRVSGPDEYQHGSPFNSLPPFNAARSSLTGSDADSHRPSLSGYRANANARNGHAYSQGDPFEPNDIDALDYGGGSRSLGSSYKQVKLAPKTELTKPLKPQEGIARAIALYNFKAVQPDDLSFTKGQVIVVTQKSQDTNTWWRGKLEGREGAFPANFVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4L8</accession>
    <name>A0A401H4L8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1600380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620290.1">
        <property type="nucleotide sequence ID" value="XM_027764489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4L8"/>
    <dbReference type="STRING" id="139825.A0A401H4L8"/>
    <dbReference type="GeneID" id="38786294"/>
    <dbReference type="InParanoid" id="A0A401H4L8"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="10">
        <location>
            <begin position="49"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="134" mass="14942" checksum="D5F8EC218E6CF692" modified="2019-05-08" version="1">MLTSFQTFEFMQGRTSVQAGIVLDLRDQQTGVPLWSLPCSVSMRKDIIVACENHQVAQTRRIITSPAPLESTSLVFAYRLDLSFTRVVPSSSFDVLSENFNKAQLVFAVGGVSLAIVIAKPMASGKRLRERWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4Q6</accession>
    <name>A0A401H4Q6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1600870</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620338.1">
        <property type="nucleotide sequence ID" value="XM_027764537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4Q6"/>
    <dbReference type="FunCoup" id="A0A401H4Q6">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4Q6"/>
    <dbReference type="GeneID" id="38786342"/>
    <dbReference type="InParanoid" id="A0A401H4Q6"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="66"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE89425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="36108" checksum="A091D5F9823ADAE1" modified="2019-05-08" version="1">MDQPTFLFGGLALLSVTGITCHIALVLFSPAPRTARTSETYYRCASSPSTPKPLNTVSANATVELTVVIPAYNEMMRLPDMLATTMAYLTAPERASRTYEVLIVDDGSTDGTADLALKLATGYPRSDIRIVSLAENIGKGGAVRHGMLHSRGKRLLMVDADGASRFDDLDLLWVEMDKIAPNDEAAIVVGSRAHLVKTEAVVKRSFLRNVLMYGLHTLLRIVGVGHIRDTQCGFKLFSRAAAQRIFPVQHLPTWIFDVELLLLAKQADMPVAEVPVAWHEVSGSKLHVVVDSLQMLRDLLVLRANHVLGRWTVVPAVQNASIVYENGNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4T2</accession>
    <name>A0A401H4T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620273.1">
        <property type="nucleotide sequence ID" value="XM_027764472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4T2"/>
    <dbReference type="GeneID" id="38786277"/>
    <dbReference type="InParanoid" id="A0A401H4T2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="127" mass="13739" checksum="E0D8FB668CE9016A" modified="2019-05-08" version="1">MVLAALAPAVPDDAVRAAMHSPSRLKLMATMASTFTDMPELRDVQSVTAFSPHVRTYPGRSIDTPTAPPPSLSFPRWHIYVPDTPDSGPSPLSRCDYAQISEGLFDLPSTRLVGVRALYTAADREGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4U4</accession>
    <name>A0A401H4U4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620336.1">
        <property type="nucleotide sequence ID" value="XM_027764535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4U4"/>
    <dbReference type="STRING" id="139825.A0A401H4U4"/>
    <dbReference type="GeneID" id="38786340"/>
    <dbReference type="InParanoid" id="A0A401H4U4"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="485" mass="51939" checksum="0BA6EFBBB8112284" modified="2019-05-08" version="1">MSALPVPLNVRAEDEAILKLPSEHGPASLPVSNSTRSFWIDTPGANPHASDGSDGTLTTDADICIIGSGITGVSAAYHLSQLLANSTASARPLKAVILEARDFCSGATGRNGGHLAPHAFSDFRGHAEKHGTAEALRAVAMEFYTASEIVKIIKEKKKESIVDLVEGGRMELLISQQEVVNEKANYEAAKAAGANVAGVTWLTKEEVEARYGAPYPGVNMESHNLWPLKAVAFLYELASSSPDLVLTLHTRTPVTSITPLESEAGPTSRRWNVNTPRGAIACSYVLHATNAYASHLLLHLQGPAGIVPTRGQIIAVRADAPEEKVTKSGYIANEGLEYWFPRPVEANQTSPLVILGGGREVAPKHEFHETDDSVLNKQVGAVLRKFLPSVFPSLYNVKEPEMEWTGIMGFTASGDPFVGPVVDPADPASVALYKGQYISAGYSGHGMPRAFACAEVVAQMIVADITGKSWTAPSWLPHHYLTTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H546</accession>
    <name>A0A401H546_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1602190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620470.1">
        <property type="nucleotide sequence ID" value="XM_027764669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H546"/>
    <dbReference type="STRING" id="139825.A0A401H546"/>
    <dbReference type="GeneID" id="38786474"/>
    <dbReference type="InParanoid" id="A0A401H546"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019341307" evidence="2">
        <location>
            <begin position="24"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="595" mass="67133" checksum="DBF1A933A4D470F6" modified="2019-05-08" version="1">MLIPFIIALVLPVCVLTTQHALSVPGPVDNSTAPFIFNSLASLLAQWPNTYHANGHTIITGVLEPFTLLYHARKDANLPPSPEWFAFDAEMSYGIMAGRGGQTYMLTYRNIRPMKIVYFDGMSASLSGTGWLDTQEVLIAGKGQNGEPDSIVWWDEYTRADKLCKWAIPRGVEGIVRMNAGFEVLWCDFNSPAIQLVSHLNITPPGTPPSTPWVPPAPAPGPGPDRPGREPGTGRGGPGSDRRRPGGPWGQLPPLSLSASNEWLRAANHRSVFPQPHVSLDYSTFVTFYHPRLHSLVPSRVGQHMRQHRIWPNVSEADAHSVIHELDEVLRRPGWRNGWPFGTGMDWAALARDIVEEWADRIDQLHEFLGNTTAEMDGGHWQTSNTTQALATVRRLAYSPLNPYMDTGSAPNVSAWTLFFEMKLSPSSLLFPHRPLPYRVNTTALQRCTYSSTGFLHYNPHLRMTSQEELLLISIETIQERLCTDFGTLFVESMGADDKLELEEAQVFLQNWETRIAALMDWLDWTEWMRCEEVCPRDSVCTMPLWPVVRWGNWPRGNSTNEDDPSSWKPQCVSLVPMERWPGPGRRDTWDDLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H596</accession>
    <name>A0A401H596_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1602340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620484.1">
        <property type="nucleotide sequence ID" value="XM_027764683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H596"/>
    <dbReference type="FunCoup" id="A0A401H596">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H596"/>
    <dbReference type="GeneID" id="38786488"/>
    <dbReference type="InParanoid" id="A0A401H596"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="343" mass="37162" checksum="BA62184CC1F2DDFE" modified="2019-05-08" version="1">MVRNTTSLGGTASDVTIGRIGHGLMMMTWRGKTDALSDEDAFDAIKSGIDALPPGVKMMLNSGEFYGPDMSTANLELVARFFEKYPEYADRTFLSVKGGVKYRSFAVDSSPENLKRSIDAINAALRGTKHLDLFESARVDSNIPIEEAVRTLSGYAKDGLFDHIGLSECSAETLRRAYAVHPIAVVEIEISPWSFEEETKKVIATAQELGVAIAAYSPLGRGFLTGSIKSRDDLAEGDVRRNLTRLKEENLAHNLTLVDALKAIAEKKGVTPAQLSLAWVCSLGPHIVPIPGSSNKKRTLENLAAGDVTLTAEEKAEIEAVIAGHEVKGDRYYGDPKAAHLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5H8</accession>
    <name>A0A401H5H8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1603360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620585.1">
        <property type="nucleotide sequence ID" value="XM_027764784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5H8"/>
    <dbReference type="STRING" id="139825.A0A401H5H8"/>
    <dbReference type="GeneID" id="38786589"/>
    <dbReference type="InParanoid" id="A0A401H5H8"/>
    <dbReference type="OrthoDB" id="2804661at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="15002" checksum="0561CF96E790161E" modified="2019-05-08" version="1">MQLGKWRHASQIPTEEDVLAEPDSYPFTEEIDRILTPHIHVLSALLNSPEEVDSTSVPVLQYLRSDAGSDGAKSVQSPGNKSLGKPTKTSEVDSRFRQHPAVRSGMVPHTGDLDIVEQARINNWFYLKVPGARKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5N1</accession>
    <name>A0A401H5N1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620660.1">
        <property type="nucleotide sequence ID" value="XM_027764859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5N1"/>
    <dbReference type="STRING" id="139825.A0A401H5N1"/>
    <dbReference type="GeneID" id="38786664"/>
    <dbReference type="InParanoid" id="A0A401H5N1"/>
    <dbReference type="OrthoDB" id="3331951at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="467" mass="52360" checksum="2D38E860BFC721FA" modified="2019-05-08" version="1">MGEDFIQTVETKMGGKVLILLALPTEKPTQIQRTKLQSPDTGGFLKFTDSVDDWQKDLWKKWGMWAMNVMIPDELKDNDAEEEDEIALTDVQHEIDDDGNAIVPAFEETWKLTQKRHLVRAIVTHQHRKIVDSKRAKCPWKKISEDVRKYIDEACWPDSVVFAEPWNIGVDNIDLLLKHWANRQAIGSVAFQFLVAAGGGDAVKPRGKKQKDVTDMNVGDSADEGDQDDNDNEVEVRVNCHMKGKGKQPAMRKKHVPPHSEEKFDLDNVSSGEDDSVGVKTKAAMNTAKSTHTANTAYDEEGWQPFSAQDLVDVPRMGEASSSGVAGASAAIAHARKLYPRIANHPEDIILWPRSMMVDADWYKHDVSRIVIPPPAFSLPDPAENDAAELEWVDCQKAILLTTSARFQGFRILDLEHIVQRPSMAQLDNPGCFAPRLLADDTAGIPEEYVKVWKYEPGVWQAIEHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5W2</accession>
    <name>A0A401H5W2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1700750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620663.1">
        <property type="nucleotide sequence ID" value="XM_027764862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5W2"/>
    <dbReference type="GeneID" id="38786667"/>
    <dbReference type="InParanoid" id="A0A401H5W2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="136" mass="15381" checksum="CD5AAFE8B9599E1D" modified="2019-05-08" version="1">MGVTEGPIRMSDAAGPMSQVNFASKAGSAKKVKDRHERQQNIRRLFTATGRMSFYVKTAQPHFGMDLISADEVDKLCEKLLWEVHETNWHCELHVLDARLLDMSKWSSMHCWECEAQLAKVWDKQDSGSGLTVAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6J7</accession>
    <name>A0A401H6J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1800640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620955.1">
        <property type="nucleotide sequence ID" value="XM_027765154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6J7"/>
    <dbReference type="GeneID" id="38786959"/>
    <dbReference type="InParanoid" id="A0A401H6J7"/>
    <dbReference type="OrthoDB" id="2801804at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="335"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="664" mass="76273" checksum="2C2F92D0512EFBEE" modified="2019-05-08" version="1">MHRKFVKMSVSDFMKNFLPGEPPDMPNFERAFSGMPSKGAIEAYFYEPFKDAVNDADMCPCYKVAITQYKPDLNDSSKQKPDAALYPVNEVPTDARPNWNIQRLHFEFKRLSEQHDPLNDKPKSELEPDSQERADVRGQCISYAEMLLMHQQRAFCFTVAILGREARIFRWDRSGAIATERFNYITELYLCEFLWRFAHLSPEEQGDDLTAIEVEPNSEEVRLMREMAKPVEERCGHAHKYFAESLDPSWKWWKLLIDIKDDTPGADADHKVLDCSTKTFVWLKDALRVDHDGMEKEGDILHRLNELKIRNVPTLLQHGDVLQHGDILRQPTLILVTLVFDCMQAHKQAMEKAHLTHHDISGGNLLINEYESVDPFGKPCTVRDGILGDWELSKPIPLEGDTSNRSARQPGRTGTRQFMSVNVLNDPWRTIVIQDELESFFHVLLYYGARYLAHNFLDVTGFLHWFFDANFWDVANAGFVCGLFKDKAMHTGVIRHEQKILKFDDGTGHSHPLNSIMTRLLGWFKAHYTISTPGESSPQSDSNREAAGPSYDYETLRRWEKLKASVDLSPYYLMKAKVDDIIRTQDAQFAGRLTSHAAMSTLLANTITDHVWPINDKKGHQLHANFNYETEKHYERTGTKRTHESIADPELPVAASSNKRARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6S6</accession>
    <name>A0A401H6S6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1801150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621004.1">
        <property type="nucleotide sequence ID" value="XM_027765203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6S6"/>
    <dbReference type="STRING" id="139825.A0A401H6S6"/>
    <dbReference type="GeneID" id="38787008"/>
    <dbReference type="InParanoid" id="A0A401H6S6"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="9200" checksum="54493C8DC501E9D5" modified="2019-05-08" version="1">MKIGHDYPMSLVDNWGKDYPIPLNINQMQKDQLSELAFLLGGVGDARHVYATLIGLRRAFENLSKAKRNKFHVHFTMLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6T6</accession>
    <name>A0A401H6T6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1900060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621070.1">
        <property type="nucleotide sequence ID" value="XM_027765269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6T6"/>
    <dbReference type="GeneID" id="38787074"/>
    <dbReference type="InParanoid" id="A0A401H6T6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="218" mass="23848" checksum="4562211B9AB13CD0" modified="2019-05-08" version="1">MSRISLTYSMIIAFSKFIAFIRQTSPFVLACASNPQGCSTSKMEELASTAQGLQFTLRSVGALGPYSYNAIADWMGRMTTLRVLPLAGFALQTSTSQWGSQITEFTTVLASALVERFSRLACVAIGVVLYMDASLTWYRVCEHPKGEVPLLDVLSDAEGEAETALMQALGRAAGAPVFGAIKLQDLYEFHLCCEAGERGLHCMKLFLLSNRILWYCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H741</accession>
    <name>A0A401H741_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1900290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621093.1">
        <property type="nucleotide sequence ID" value="XM_027765292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H741"/>
    <dbReference type="STRING" id="139825.A0A401H741"/>
    <dbReference type="GeneID" id="38787097"/>
    <dbReference type="InParanoid" id="A0A401H741"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="47"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="372" mass="40705" checksum="B24D8519BDC71D3F" modified="2019-05-08" version="1">MPDIEACRTVDMMHSSAHVYKSNTSCTAVQTSVKTALAESLAHGEFADVRLFVFSRRLRSGKVCAPRALYANSAILKAASPFFAGMLAGGFSESDIAGIDTGFPANQRSVIDADPFAEEDSDYEEGEDDEYRKDNSTIARDACDEVESSGLTLNSTHVPQDTPASLVSPAVIKQSGGQPLRTIIIKDTALATLQWLVYYLYTGEIAFSPLHSQGAECWAVERERYQIEHPKCPPPCSPKSMYRLADMLGMDGLKLLAIEDVRSKLSAENILDELFSPFSSWYPEILQAEVKFFSSNRMDLKIIPKMRKKLAAIAIQPVPHAAVALASLFEACISEPEGAAKTVTSSVADMDKDRVAPAESAPIVIRRLPRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5H4</accession>
    <name>A0A401G5H4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0102830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608323.1">
        <property type="nucleotide sequence ID" value="XM_027752522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5H4"/>
    <dbReference type="STRING" id="139825.A0A401G5H4"/>
    <dbReference type="GeneID" id="38774327"/>
    <dbReference type="InParanoid" id="A0A401G5H4"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="146" mass="16789" checksum="EB9EA3D5F0DA963A" modified="2019-05-08" version="1">MNEEIDKSAAGFRHCDGFRHLASDQFLQLELAPLLNRIISPPLRPVNGQVIHPHEWAILSRLIDIMVALELRFMQENAEDRQLIYRLDPPIDVFVFVTYDGEQATDISVLHYAFRHLVVAEIDAQLASRQLDIIENKPSKADLFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5Q6</accession>
    <name>A0A401G5Q6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0103750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608413.1">
        <property type="nucleotide sequence ID" value="XM_027752612.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5Q6"/>
    <dbReference type="GeneID" id="38774417"/>
    <dbReference type="InParanoid" id="A0A401G5Q6"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1450"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1457"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1476"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1634" mass="178838" checksum="036F9FF876C3FB4A" modified="2019-05-08" version="1">MLVESEPGHQQASNAVQETGNDVLRAGMYDNAHDSTYMDIDNYDGGSELPAVGLVAHVGTANAGISSTAIEAGNGANGITADRAVSSDDIPDPGCLALDNIPEDPAEIPEVDREHANIIRMAPPEYVGLDELSDLAQLSEMKLSMEFIRALEQASLDDEGMRLDADTLERLRNPPRTTVDVTDPSLRLALDLFLAVGNSSQETYNTVRDAIMRRYPDDILPSYAQIKCQVAELSGVVPLIHDMCINSCLAYTGPFSALETCPKCGESRYDPIQLAVSGGQKKIARQEFHTIPIGPQLQALRRDPASATALNYRAKRTEEILETLQQNDGNLPAYEDLLDGSDYLSAVADGRIKSDDIVLMLSLDGVQLYRNKASDCWIYIWVVFDHAPDVRYKKRHVLTGGFIPGPNKPKNVDSFLFPGLHHLAALQREGLGMGDAARDTTFLSHPFLALETADGPGMVYLNGFVGHHGRRACQLYCDTNGCHKPGGSHYYPALLKPLDYDVEGCDHNDINIHSLPACSSEKYMENLRYLMMSSSETQYCKRRLETGITKPSIFLGFSLQHTLGIPGSFGSDIMHLASLNLPDLLIPLWRGTFECDKTDSKATWDWAVLQGDRWKIHGQAVADATPYLPGSFDRPPRNPAEKISSGYKAWEFLIYIFGLGPGLLYGILPDKYWKNFCKLVGGIRLINQHKITRNDLQQAHKLLLQFCIEFELLYYQRRVDRLHFVRPCVHSLLHLGTEVVRVGPPICSSQWTMEHTIGNLGQEIRQPSNPFSNLSQRGLRRAQVNALKSMIPDLKPMEDSLPKHAINLGSGYVLLRARQRTATPLRDCEAVALTTYVHDTLGLTCNLSSFMAPSVQRWARLRLLNGQVARSAWKEKMKALKNFQIGNELHFGEVLFYFQISVNNEIKSLALISLYSRPHAGLLESSSYTLWSCAYQGDAALQIVDVNTSLAVVAMVPHNPFGDADHHFFVVEKPGLDVAHMGGNDELDINEGQLLVEPHVSEMSSQARHWPYGRSQPGYGGGLAAAYVLDATGEMYSDGATSPTPSSASPGPLSQSLLMGVDEQDNSFAMNTKHTLSHLRSFPVNTSQVTPTNTNISTINHLNAPFISSSSSPFPSSHNSMFSHSLQRDILVLHTEKATMMAAYQTLAEAIPQALSVTNPFNLTISTSSTSTIPSASSSLPPVMQDDYPHVKWWTKESWTKRAVRPEPYKGNNMMLYVEEADGTPISGARVDEIRKVARSIWAHLASIQLTPLTWGKASVVAARLYNDEMARTFPELQYCASNWKAEQIGIDNYPSWRNYRARKAAGVKQEEVDPTAVEVSPRKSKRGHRDETENDTQSIAPASKKTKTESSKTALISVTTSEELLRSLDDESDASPSDNTSISIVAEKPGCTSDKGKGRAVELKLRNPLSSITAGNIVHSETLYAAAVVPNNVPITTPVSREVGATPSLAATSAPSAPPPSSTPPNVPISLDHPVVTSVDLVSSSSGSATVPTAQSDEPSDLFSMVAPPTEQSVDLAASAGCNPGDTDSIPAIPKFTMSSHTSNIEAQALLKGPAKRTKHAKMRPGDTVTPRNLCAVTWIKAHPDGTTAEFKQYFDLLPAEERKPFEEESKRLKQTGIARLSVMSSTMSGSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7B7</accession>
    <name>A0A401G7B7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aprataxin and PNK-like factor PBZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0109360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608967.1">
        <property type="nucleotide sequence ID" value="XM_027753166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7B7"/>
    <dbReference type="STRING" id="139825.A0A401G7B7"/>
    <dbReference type="GeneID" id="38774971"/>
    <dbReference type="InParanoid" id="A0A401G7B7"/>
    <dbReference type="OrthoDB" id="2745518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="57613" checksum="27DB5126C26B4F47" modified="2019-05-08" version="1">MPFSNLTHDALDRVLTFLSDFNTLSAAILIDKNIYHVFQARPKSILRAVAYNAVGPALPAALRLAKNEESPTEPPAEDQLTGTDVRFNRAEADRIVAGATVISGFEDLFSWRHKDRSSPITKLTPAESLRFHNACYRFWAYCAMFEDTHYDWDLEDDLDNIPEDCIAFFNAFSDRDLFDIDRLVSFLVETVQWIDHVHYPEGGYSNHAGFLAEWPEAILKAYRGYGLHALHHYMQASFRNGFYSEPFQSVMNSRGIIAAGARAEKRSKAILEAVVGDQDRCHRCHTVCGVNLWGASNFHLLKGILNADDLLRSLPGHLRQNKTEMRLILGILEGAAFPVPGFDWPLPTFVAMPPLHNPNAPPYALPAFHAQVAGAALPAPNPPAVPAPAPALVPAPAPAAAPVIPGLAALASMPAVPPDGPGIDYAELFGEILSLPAGADEGTDPTLGAWDADGWFCVGCVRELCRARLWRWWLARKQEEDMRIEEDCWYGWNCRTQVHKASHATRLNHLCKPAKGDPGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7L4</accession>
    <name>A0A401G7L4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0110210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609051.1">
        <property type="nucleotide sequence ID" value="XM_027753250.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7L4"/>
    <dbReference type="GeneID" id="38775055"/>
    <dbReference type="InParanoid" id="A0A401G7L4"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1446" mass="160528" checksum="E5886CA41332D6ED" modified="2019-05-08" version="1">MTSAQSAAQGFIRGLKAASDPPHPGGPLKIELASKAWEDTSLYIPNKAEVIVDWILMRLLKHKSRDADPLLDDRYWQLLSEILSCDSLRAGESARAAKAWLIPLLNCLPIAPIVRDFFNMLSSTDSEVNLNLNALVSRCLVVVWPLAVPKIGIEALLECFGAVLGWSIVPHEGEEMNGRNVVQAQLLVVQAYRAALANAANKKKLYPTFVQNHLVHWLTCIQLQGNETTKQQVLASEIYSAGVDTLFSLEVLRQAGDQHFDAALKEEFTKGMANTPETVLTSFPRLFMSFMQSIKKHKSALFGHGSNQVPGDITKQVQGAGMAFFASCDNLLTEGKESEQLWLTRIALLAVVDSENLYNVRDEHAVQLLKRSGQLAIDVLEFASESRSNQRLFQRLNSAIELLSTLARIDYDIMSPALPAILPKLVAISECMPSVLIYLGLLLDYHAKTRTMPSFIVYWLDAFSIHHIQAVGQQPRTVYHDTFSGSLLSPSYLTRLSNSIRSFLTPGQVLETVQIALQTFKDAFDKFTQHDAANAAIHGDGARKKRKKGSSTAPAKSADPEWAAVSFALVARAVVVILTSTPMHAILEDVHHEIQQLLHEVCSAMVPVAPEEALDRLGKDRKDTWGWQIVAGAALRVHYGLTMSPQLQFDVPFDEHITSKMLSSVISEESSPEFSLEMFRSLLRQSEQDPGDAENVFDAVLQYLEHHIGRSDASWSGKSHELTGNVAYDQGAVALCHLLFERWLPHFHMHASEVQLARLAKLIMSMEFGHLSPTAPSEVQKAVNVTVILTKAFHNAEFWELHRLRDVLLAEMQSETAPLDLINLPLVFSELQDGSAQSPIEDMRKIVRVYEILLQAPAEYLPRTSRHDFLRRALAADVTMAIAPRTNGPTNVNRRLILVVREFVCRTMSYLGTIDHTAAADYLAFLMEPCLSRTTTGDTLDDELVSVTLDIIGMHLASFLKAARKGEEDAVTAVIGRFDDILTSAMSLEPQYLQHGIRQKSLLRFIDILTSDHESSHFSETLRGSLRRLQAHMISVYLPSMLKLVAQDGEASKVLMQGEILQTWSCALSLGRWLNFKGMSTDKFGHLLVGKLLSLKAETPPPIRICLFVSDILFAELSTCTDVNRPVHLQCIIAAYITFFRLCGSSGLVDKQLSEALSNIDKLPIRDIASLVRFSSIMVHDAPQGSLKTTQSHVTRCLILFADCSIFLTSSHLRREVLNFMSRHFNDHPASVRSMDLSSIWSILGAVFAGSAEHDSTTDTTIFHEVIATINALVRLRRDLVLHTLPHLGMILRQLTIALRSPRPHLGGKQSRLVMNTLPKWVSADTPLSSEESKALARLMTTLSTKTVVRVHGPSSESQKPGSLVRPFSKHAAYVLTAYIDAVNDPLCIVPTQIRRELQPGLFALCDMLGEHNRDAMMVSALGAGGKATMKALWREYEKQRYAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Z5</accession>
    <name>A0A401G7Z5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0111800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609209.1">
        <property type="nucleotide sequence ID" value="XM_027753408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Z5"/>
    <dbReference type="STRING" id="139825.A0A401G7Z5"/>
    <dbReference type="GeneID" id="38775213"/>
    <dbReference type="InParanoid" id="A0A401G7Z5"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019325227" description="Cupredoxin" evidence="1">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="41357" checksum="318BD910A2A666D6" modified="2019-05-08" version="1">MLFPIAVLSLGVVFASSAAAQQVFDVTVGSSNGSLIYTPSSLSAAAGDQVVFHFEQKNHTASQSTFEDPCHLVDGGFDSGFMPVPSNQTNDFPTFTVTVNDTNPVWVYCRQAANTPQSHCGNGMVFAVNPGPDGSSNSFANYLQNALNQGAALKSSVSSSAASTVSAAWTTAAYGGVTIPAQPTPIVVTETITVQGSSWVSVYPSYIGSPEPTPVSLQGAVHTVVVGGANGELTYTPSNITAQPRDTVVFEFHQKNHTATQSSFPDPCRILTNATTDQVIGLDSGFRPVAANATEFPTWNFTVNDTAPTWFYCKQHTPTGASHCGSGMVFAVNAVADSPRNFSAFQELAMELNGTNANSSSGSGSGSGSASGSSSNSAEASFGAQLAFALGSVLAVAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G802</accession>
    <name>A0A401G802_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Maintenance of mitochondrial morphology protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0111910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609219.1">
        <property type="nucleotide sequence ID" value="XM_027753418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G802"/>
    <dbReference type="FunCoup" id="A0A401G802">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G802"/>
    <dbReference type="GeneID" id="38775223"/>
    <dbReference type="InParanoid" id="A0A401G802"/>
    <dbReference type="OrthoDB" id="5599157at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="10">
        <location>
            <begin position="79"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="301" mass="33999" checksum="C2357EA320712667" modified="2019-05-08" version="1">MGNAYIFSLQPTFTQGLILGQFSVFFLLVLILKYLFFDTVSEHSNKVSSYLPKVERDDEDDEFNANLEQLKLKTEGQSVPESADWLNVLLQQVAEVYRMKLRDNKPGPEGDEVARKRVEKYANQIRPPGFLDPIKVHSVDLGVVAPQLSRARRKHYNPPDSAIEFDMTYVDTLSVSLSTSVLFNYPFPAFARLPVSLTVSLSLFSSSVLLTPPQPQSPHPTITFTLPTPQTEFTLELRTTSLMGSRAKLADVPKLHELITHQIRRVLEEKGTWKVVLPGLATVKEVKEDVLREQMLEEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G885</accession>
    <name>A0A401G885_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0112590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609287.1">
        <property type="nucleotide sequence ID" value="XM_027753486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G885"/>
    <dbReference type="STRING" id="139825.A0A401G885"/>
    <dbReference type="GeneID" id="38775291"/>
    <dbReference type="InParanoid" id="A0A401G885"/>
    <dbReference type="OrthoDB" id="3233180at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="515" mass="57378" checksum="1C4AB84B5A6C807A" modified="2019-05-08" version="1">MVSDSDTESESQPSVFEWQAADFAHVSSTQRVGSSRGTAEEARFSPRELQLAVDDLRAIDLAAAEHDATLHIVIQRVSSTMLCFLEGIIESSIFSDDGEQDVYIAMGQLLQFSFMSLLFDYRKLFHGIAARDTSHTSAPSTVVCWVDVVLSKLGDAVISLIGRHCTDVKTLEWSFSTLKQQRETDSLYAAVQLPDGWTDVPNVINAEHASPAAKRLALQLTFAVYVVGPQLEDAGTTSDQENDVLGSYADLQSAEHAETEKVRYAMMLSLFAAMDSVQLDEDRTPFRPHTQAALLHYMTTIMYPDNFCASAHDLVSPCAALNVAQTILLKWGHVVPWCWFLCDDPRIFNSEVIDYVTINWLHHLDNSDKDTDKCAEYVEPWHEEVASVIATYPRAAIVFVNRILHHTVSVLLTVPPGHLTLSSLDALRKSCWAAAQLLRSSQLGDLDVSSLYAAMCRLFMLLRDGEEDLAVKDWIIECLTFASRDNLSSVMSSILDDTKLSLTLRMEEKISGLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8B8</accession>
    <name>A0A401G8B8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0112830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609310.1">
        <property type="nucleotide sequence ID" value="XM_027753509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8B8"/>
    <dbReference type="FunCoup" id="A0A401G8B8">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8B8"/>
    <dbReference type="GeneID" id="38775314"/>
    <dbReference type="InParanoid" id="A0A401G8B8"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17756">
        <property type="entry name" value="MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000241">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054125">
        <property type="entry name" value="MCM5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21933">
        <property type="entry name" value="MCM5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="337"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE78397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="744" mass="82044" checksum="8740E39FA9EF51CC" modified="2019-05-08" version="1">MSGFDADRVYSVSVHDLPNASSPDTPSHTEKLLLDFLLQYRIGGEFIYRDKLRANLLLKQYQLEVDLRHIGLYNDELAHDIQEKPGEILPLFETAAARAARTILFPVAGSSTEAAAQSIPNIQILIKSGLNLQQFRDLAANTMNKMVRIPGIVISASVLSSRATKLHLQCRACRSTKIIFPASGLGGIGSGSDRGLPRVCDAPEIENQKKDCPLDPYLIIHSKSTFSDHQILKLQEAPDMVPVGELPRHMLLSADRYLTGQVVPGSRVIATGIYSTYNSAKNKSAGTAALRNPYLRLVHLEVSSPSAGGSGGSNPFGLQFTPEEEEEFGEMARSEGFYERFAKSVAPSIFGSLDIKKAITCLLFGGSKKVLPDGMRLRGDINVLLLGDPGTAKSQLLKFVEKVAPIAVYTSGKGSSAAGLTASVQRDSVSREFYLEGGAMVLADTGVVCIDEFDKMRDEDRVAIHEAMEQQTISIAKAGITTVLNSRTSVLAAANPVWGRYDEGRSPGENIDFQTTILSRFDMIFIIKDEHNEQRDRMIAKHVMNIHMNRPNENADENGEAVGEIDIDKMKRFIAYCKAKCAPRLSAEAQEMLSSHFVSLRKQVQQIEQDNDERSSIPITIRQLEAIIRISESLAKLTLTPVVQSHHVEEAIRLFKSSTMDAVSAGSADGLSRGELNEEMGRIEKEVRRRLPIGWSTSYQSLVREFVTQQGYSSHALERTLFVLEKREIIRFSGQNKVVHRVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8K8</accession>
    <name>A0A401G8K8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0113770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609401.1">
        <property type="nucleotide sequence ID" value="XM_027753600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8K8"/>
    <dbReference type="STRING" id="139825.A0A401G8K8"/>
    <dbReference type="GeneID" id="38775405"/>
    <dbReference type="InParanoid" id="A0A401G8K8"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="220" mass="23189" checksum="7B94833C08E71D99" modified="2019-05-08" version="1">MHLLVLGATGPCGVQLIQEALSTSHSVVIYARSPQKLPDSITSHSSVFVVKGELGNVELLSQAMAGVDAVLSALGPAVKSGPFHPSDTPLARAYAAIIDVMKKCGVKRLIALGTASIKDDRDKFSLEFVALVSGVALFARSAYKDVVAIGETIRAQGDGLEWTIARVPILTQNEKRDVLAGYIGDGTTKTTLARAGFAAFVINEVEKNEWCGKAPLISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G938</accession>
    <name>A0A401G938_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FYVE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0115720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609594.1">
        <property type="nucleotide sequence ID" value="XM_027753793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G938"/>
    <dbReference type="STRING" id="139825.A0A401G938"/>
    <dbReference type="GeneID" id="38775598"/>
    <dbReference type="InParanoid" id="A0A401G938"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE zinc finger" evidence="5">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="319" mass="35379" checksum="0EB0D23625D225CE" modified="2019-05-08" version="1">MSLSSTLLSRLSLYRHSTDAKDETASIVSSQGSCSSSGSSSMSSSVELSVSDRSLRPLDCQFPRTRQHEHLAVLIPKHLWKPDAQASHCDIFRCHKKFSMWERKHHCRKCGGFLNPPRDIPIAVFDSPTSPVRSWRVCDDCWYQIHGCPSPRPSVIKTRPLALVRESDSDTSSISSSVSSSPEMSTLRPSMRRIHASPRILHSPLRPSTPSSSPPSVVGALIEDAELSLGELESYPLKHSSVVCKANGGGRWEPKPIVALVSDRLPGGKAPYEIELEREEDEIRRRRANPIIRNGDFQLRAPREVEPRSPAGPICLSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G966</accession>
    <name>A0A401G966_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Probable proteasome maturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0116170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609639.1">
        <property type="nucleotide sequence ID" value="XM_027753838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G966"/>
    <dbReference type="STRING" id="139825.A0A401G966"/>
    <dbReference type="GeneID" id="38775643"/>
    <dbReference type="InParanoid" id="A0A401G966"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="140" mass="16026" checksum="FCB77EBFFB2CE791" modified="2019-05-08" version="1">MEPSLRLVPAPSPKHASLKETANSLGLHDTLEYGPRSFAAEVATTSGIRDRLQNWQETQDNLHLTMQRNLYGLHMPMRLLMERQMVTHSPHMPALRRSNIHLDILMGRDETLECADFMMPVSELAQPLSIHGEMEKKLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G983</accession>
    <name>A0A401G983_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0116130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609635.1">
        <property type="nucleotide sequence ID" value="XM_027753834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G983"/>
    <dbReference type="STRING" id="139825.A0A401G983"/>
    <dbReference type="GeneID" id="38775639"/>
    <dbReference type="InParanoid" id="A0A401G983"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="85"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="167" mass="18707" checksum="25DA67B2FBCA1D8B" modified="2019-05-08" version="1">MKAEWERWEQVTKYITPGHKLYRASAPNYNEGEGDHSQKLTATAVKFLTDRGVDSIISFNQYPYKDDEKKLLDAAKISYLHLPVKDFTAPTLAQLKSAIIFFTGPKQHATLVHCGYGHGRTGTGVTALQLNATKGVNPPESEWKSQNHVEKPEQEAVLRALRDSLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9F4</accession>
    <name>A0A401G9F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein SYM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0116850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609705.1">
        <property type="nucleotide sequence ID" value="XM_027753904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9F4"/>
    <dbReference type="STRING" id="139825.A0A401G9F4"/>
    <dbReference type="GeneID" id="38775709"/>
    <dbReference type="InParanoid" id="A0A401G9F4"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="20531" checksum="AE1320632BE02C22" modified="2019-05-08" version="1">MAALLQSFNAALVRRPMLTQCATSAVLFGSGDVVAQQAFEQKGREHDFARTARLAFYGGAIFGPLLTKWLQLLNRISFASPIKGVVYKVWMDQTMFTPAVIGIFFGSMTFLEGKGVAQAQERISDAYVPTLVRNWGVFVPAQALNFALVPPHLRFVAVGAVSLFWNSYLSAVNARNARLEAGGEGKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9G7</accession>
    <name>A0A401G9G7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">37S ribosomal protein S17, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0116820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609702.1">
        <property type="nucleotide sequence ID" value="XM_027753901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9G7"/>
    <dbReference type="FunCoup" id="A0A401G9G7">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9G7"/>
    <dbReference type="GeneID" id="38775706"/>
    <dbReference type="InParanoid" id="A0A401G9G7"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004123">
        <property type="entry name" value="PRK05610.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12668" checksum="BC22BB21516C6494" modified="2019-05-08" version="1">MPPMAFTGLVTKVGVMNKTATVTVSRFILHPKTGKRLERSKKYLTHDENNQLRLGDTVLIRNCPPISARKRFTLENVLKSPEAERDELHARAAAEQHQHLPPSRPSSSEDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9I4</accession>
    <name>A0A401G9I4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0200060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609722.1">
        <property type="nucleotide sequence ID" value="XM_027753921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9I4"/>
    <dbReference type="FunCoup" id="A0A401G9I4">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9I4"/>
    <dbReference type="GeneID" id="38775726"/>
    <dbReference type="InParanoid" id="A0A401G9I4"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="516" mass="57878" checksum="BCF1A74C99985BEB" modified="2019-05-08" version="1">MSDVVDEKKLRDAEMEVSAIPVDKEDFASAISDGDDALKVVGTQRTHTFDKEYNRKLRRKIDLLIPPLCAAVYFTQFLDKNILNYASIMGLPIKGIDFNNVAMAFYLGFMVWQFPTQYIAQKFPIAKYLGVNVTLWGVVVILHSTAPKFSGFYACRFILGMLECCVAPILILIISMWYKKNEQASRISYFYLMNGLTSIFGGFIAYGLTFYEGGIPQWKLIYIILGALAIIVGICVLIWMPDSPVTARFLTEEERIAALERVRDDQAGTHNKHIKKYQIYESLKDVRTWFIFLIVMCIGLPNGAMSSFGNLVMKSFGFTSRQALLLGTPSGLISAVTVILFGYWSDFINDRMTLITLSMVPNLIGMALMTAFQKSGNKGVLLFSIYIQGFSGPCFPLVYAWNASNTSGHTKKVTLNAITLFTFGLGNVVGSYLFLPADAPNYIPGKIAIVVLIAITMVACIVLRFINLHMNKNKKRALDAAIAANNWTEEDVQREREKAAFLDMTDKENPYFVYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9S2</accession>
    <name>A0A401G9S2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0201210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609837.1">
        <property type="nucleotide sequence ID" value="XM_027754036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9S2"/>
    <dbReference type="STRING" id="139825.A0A401G9S2"/>
    <dbReference type="GeneID" id="38775841"/>
    <dbReference type="InParanoid" id="A0A401G9S2"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="52"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="373" mass="42668" checksum="41ACDE5FFC727484" modified="2019-05-08" version="1">MKCSVSDFPSWTLCTPDEAQGYAKATAEGLYALLPNEIFWRDRQVYLEEHGYQLRPRYRPGWSPSWLEMNVTPSFCEDSISLLWRDVIDATRKADGELVSLKSVEKDGSEVTIARFLSRPELRLDPTNHCVPMVDILPDPIDSKAAILIMLYLRPFNDPGFGAIGEVVEFMRQTLEGLCFLHDQGVAHRDCAAANIMMDARSLYPHGHHPIRIAASQDGIHMLAPLSRSDCSVRYYFIDFGISSLIKKGESPYVLGRQGRDKELPELSSEITYDAFKVDIFTLGNLYKKEFLQAYLDLEFLEPLVQKMTAHSPDQRPTAAVAFAVFESIRHRQSSSLLRWRLRRRDETAPERVVYDTMAAAREGIYRLRHFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA87</accession>
    <name>A0A401GA87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0202400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609956.1">
        <property type="nucleotide sequence ID" value="XM_027754155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA87"/>
    <dbReference type="GeneID" id="38775960"/>
    <dbReference type="InParanoid" id="A0A401GA87"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="840" mass="90909" checksum="0EC553E119CD880B" modified="2019-05-08" version="1">MNILFRSFFITATIAFAFTARLGTYLVGATPMFDDMRYMLWEEELASLVPYSIYAESTPSTVSSIPATTVFSAVPDPTPGPPAVSSGITSVISPEIHSTDVLSFKPVPSPSAGCHVDTAQSNDIGRLAESTTMRIQGTALYHILIIAGYPSPAEIAKYRTLRLLALSTDPSCFSSTYSRETAFTEEEWSERLYSGSGKKATFVAVRTDSGEWVGMVTMVTPGGIPEIIYVPTVREKTYLVVGMWVCPEHRRKGLGTRGAVLVLEFKTWNEAGKGLYIRRAGLEELPVEGETESVWMRKRLTPRTDPSPLAVLTAVAVQLVPGEFIVAVPQGLRASCSQRSRPMDNRAQPTVVTGPTDFNLPLTSPSIRLHSQYQQKRPLSSRVSPVSSSGSSQDATDRQTQLEESLRRTVTLVFWYQANSEPIRLHQEISIFPFFQLSQFTQLIADLQLPSTAYVDTYNPDTRTWEQQALSAVRVVDSNQRLLYRTRRSLLEGLMDNECPGLADEVAMQPSALTTRLPPRVSIGKRSAAEIGPTLTPSPPAKCPRSESCQGYFTGVSQHSSPGNQACSASSSLTSSPTGSPTTTLGQQSPSDVPPAQQQALLTQHSAYVPTSGRHLLASRSPSTAQSPTSSDGAGASRFSGKRHWPTDFTVAEVHAGLRQMDAEVAAQPALTQSVAFARVFNCKYVKSTVCRHKAVWRSAGRDVLEAVGERTLWSEFVKRVEGRAGRRRAGGGAEHHEGHEAATVPVTIGIPMLVHVPPVEPGVKPRVSVEDPAVGPLGPPLPPNDIPGDTVTFTRRNTGDSPIFESFPSRTDDTSETPGALSAPLPANTSAATHPLAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAX2</accession>
    <name>A0A401GAX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0205130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610228.1">
        <property type="nucleotide sequence ID" value="XM_027754427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAX2"/>
    <dbReference type="GeneID" id="38776232"/>
    <dbReference type="InParanoid" id="A0A401GAX2"/>
    <dbReference type="OrthoDB" id="3359404at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="15085" checksum="642CAE5BF8190F68" modified="2019-05-08" version="1">MQHPRLSSTRMFHAMPCPSPSRASPTAASARAYTTGASSKPALSRHAHFYSDLVPGMIPIALLGSAIYLGARLLQSNLAHEKYLEESRARVRELEAEVEALRNQQTQAQYAISDATHVRDTHATDAKSRSWWPWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBU8</accession>
    <name>A0A401GBU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein EFR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0208320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610545.1">
        <property type="nucleotide sequence ID" value="XM_027754744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBU8"/>
    <dbReference type="STRING" id="139825.A0A401GBU8"/>
    <dbReference type="GeneID" id="38776549"/>
    <dbReference type="InParanoid" id="A0A401GBU8"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="135"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="845"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1226" mass="134074" checksum="B43844E4163CB24D" modified="2019-05-08" version="1">MDKFVTVVKPSTGRGMDNDKQKQRATYKYNPYGVSKANERKFEQWKDKKRTEKIVAPLLKNGAKTSGSALTKHLLNTLTDQSNPITHSDMYQRSDHITSAATGHQRSDGRGHQKNYWELRTSKLAEQLPVRSTSSETKVLQNVSVYINGYLNDTTDIEMKRIVTLAGGNVKHTAAGATHILTSQQLSACKTHKLLTTRSKTRMCVVKPEWVMDSIKAGMRLPEREYSVIEDKTVMSLTEMLGAGSTSRSCYPPSAALLAAGQEYLPNSQELSRLTYYASNRPGKINKLSNELEKKARADCRKAQAGNTRARATLLITLYIFKALATECRRDISLLTSSLMSAVKITLCALSSDLEVAARAANVFTAWTTFTDGHLIGVDRDVTQDYLACLESFSAMGTKRSDDAEIRNRTRLVGLAALTAAVNSDALFHSITQFKTQVSTMMPALLAPLLEVDTNLLEFEAIEVKEQPTSTLLDEFQTLPALERRAASIHLHVDGDKGPSSGDVTNTSLRALSSLLAHSNGSQVSTIMTAALEFLDDSGGWGKVNNCQWFAEKGAEWTQYQYRYAVPTRLVECLIESQDAPQATSRHSTLLAMITAVFISPVPLVNLSTSDIISSLITLIFRRISIEPQDGLLSPLVECIASLGTHVYYADQIQDLAGELISRLVLVNTNGLPGRATFEKGRVQAVRCLLSGLLGLLHSADMHDAADTNETDDKKEIRTTSTSPNPPSSSNPALREAHVRPSRRTRISPEIWHDTLVLLCDHEYTVRADYAVALVSYLRNEIPRLGEQADSDGIKRLRPLQEGHSELSNTMTAMIYGDATTRFLNALHAYAYALITSSAIGFHRGSPSSSPERHIDGNASAARDESASGESPRSRDNIRNSTNVTTSSRKTSIILRALQKVPTRLSPTSPPASTLSDYGNVLAILTAVHESLPLRALLTGTPMLLALDSASRIDGDTTAPNLPLFKAVKQVVDKAWVTIGKVWSCSEVVAMAEQHMSAVAELFLPSLPDMQPSTFELPRKPILFTSEASSSGTLTCLDTQALLIALASNPNVQEATGLDQQSLLRRLAMPWTAESAFRESLETRPNYDALQDALSPLIKVAPTLMHIENLSLQSLARSTRGMGVTDLREALEGRSSVSNPNLVNAAPSISTLDHTSSMMPGDSPYKLTPTRSRPQRNKLAGPEVRDMLNKLGIGNKQNGTSQLKSSFPSLQKPRQLSPAFSPPYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC21</accession>
    <name>A0A401GC21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fluoride export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0208910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610604.1">
        <property type="nucleotide sequence ID" value="XM_027754803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC21"/>
    <dbReference type="FunCoup" id="A0A401GC21">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC21"/>
    <dbReference type="GeneID" id="38776608"/>
    <dbReference type="InParanoid" id="A0A401GC21"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="390" mass="42262" checksum="0B44822DEE0AE635" modified="2019-05-08" version="1">MTDIGRAAEEKEADKDKLDSSGTPTIDGLDMEHDGLHRLRSVRSDVGSNLARHTSTADAASLASIDRPPSEEDKFPPSKIYHPLSFAVLALLMPASVFGTLARLGLEALVTFDGHTIFPLAWVQAGGCLVMGFALALKDPFGQFYGPFYTAITTGFCGSFTTFSGWQLAVFQAWINEGRFHRDWLRDVIDGLTQTVFTLALSLVCVSFGAHLASLIQPIFPALPPPKRAIRHSLSVLSILIYAATYPAYFRLPASYRHQATAALLFSFPGTLTRYFLSLRLNPLLHLMPLGTFSANMLGTALIGMFTVLQGMHSPPSPRACALLRGLSDGYCGCLTTVSTFAAEVATLDDAKAWLYVVASCVTAQLLLLVILGPSYWAGHVSEQSTCQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCE6</accession>
    <name>A0A401GCE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0210500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610762.1">
        <property type="nucleotide sequence ID" value="XM_027754961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCE6"/>
    <dbReference type="STRING" id="139825.A0A401GCE6"/>
    <dbReference type="GeneID" id="38776766"/>
    <dbReference type="InParanoid" id="A0A401GCE6"/>
    <dbReference type="OrthoDB" id="2804000at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="709" mass="77427" checksum="E94544CDFBEC66CD" modified="2019-05-08" version="1">MPHRKSSFSTSSYAAAIAKASSEELLQYQNEAYIQLYRERDELVARERIHEEKYAKLISAIPSVLHGVPPSQISSVATDIRFAKANPIPPLERAEYPSVRFWYRQEYDAHIRELSESRSITQIDEDESEDGPKKPRYLENKDGTPFNKAQMKAATRVMREIWAELHCRDDVSYLPSTWSKKTADIAAFFYREMNLRIPELAYCHGDWKAEKLATDNYSQWTPPKKNKKKQSLSEPVDQSDESDSEVRPRRRRGGGKKKRHNSTMSENDHEGSLRRRRDSKRKRNQSSTSDEEGRNTRSPRRRRARKSPRHRSVVSRDDSSAHQDSHYQGAQRIHAPTDNVSTIAARPVPEPQPQASSSSADIDAALPTQSSVLDSPLPEHQPNASSSSATIDAALATESSALDSPLPETQPNASSSSANIDAALPTQSSVLDSPLPEHQPDTSSLSANVDNSVDDDTIPSTSVVALHTTHADAQSIPLLVPFDPLADEFDPPTPHSLPTQSKTTSASGTGVAPADSDLGAITADAPAKPKRKSPKMKANKSNDASNLFAINWLPMNQGKSRDEFSAAWAAVDAETRKKYEVLSATKKTAAKTEEAAKRKASRATKATNKSNANIAGCGRLWLGIRVLLHVEAGSTGDSFGAWGTMQGGSEASAMQGTGRRGGRGRERDGAGQGGRERDGGMAGAGLLGLQRTISKDNGPNHSLSKTVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCI9</accession>
    <name>A0A401GCI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610819.1">
        <property type="nucleotide sequence ID" value="XM_027755018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCI9"/>
    <dbReference type="GeneID" id="38776823"/>
    <dbReference type="InParanoid" id="A0A401GCI9"/>
    <dbReference type="OrthoDB" id="2989199at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="294" mass="31989" checksum="8AE15B95D2C263AE" modified="2019-05-08" version="1">MDLRDIVNPEDAGGFHTTSGAHERITNAPPPGSRRNARGRPSQKRASAKQAAGSARQAHTGLRHRAHGGSPAPTRSLEVAAPSGGRVPRSRRRYDGLHAPPHPETRNHLPAPGSAPPLSLSMPPPSPMRELIRRGGQVVAGDTGSGQRPFIMDVILNARPPVSEYTEDASLEARHRKEVQTRVSQHHYVFRDKDSLERYWADQALLCRSIAAQPPHYPPENKFQLSAERSTASWDEDGNEDPHTEAESDVRSSTSVSRTGPQSAWGHSTLLDGQQLAHCGDNGYGSSQSPRLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCS8</accession>
    <name>A0A401GCS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610897.1">
        <property type="nucleotide sequence ID" value="XM_027755096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCS8"/>
    <dbReference type="GeneID" id="38776901"/>
    <dbReference type="InParanoid" id="A0A401GCS8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="386" mass="42260" checksum="DA26829C04518A83" modified="2019-05-08" version="1">MASDAEPPDMLDIMMGESDEEDSIAKPRRPLISDLLDSPGSAQISLPLHSASQTPLVPRHTTPSLAAPFAPSNSPHEHLHRHASPKLGMKVMAVRQSIGMHSSQIPPPLHPVECSTSTLLASRQSLDVPCWKLLPFLHQLTLSTFALLTPPNSLDDRSLLSPLTLRHVHPSTSIVKQCQNCWTLTIVLPPCQDDGELCTSPPKRRPLLDDVLSPPPPPSAPSHSPARTFDDSNFHHDAPVIHYMKGSIEPVTVTSRMPSLAALPDELPIHRPTHWEQVPGLFPDTTQLLPMAVPGETNAASGSQVARLGRSFAQIAAEADSSMDDDEGDSFAVSRRCAMLRERIVRLQRELNLTEDMHVANLNASSTVFQMGYILRDIRGEAYRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDS5</accession>
    <name>A0A401GDS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611245.1">
        <property type="nucleotide sequence ID" value="XM_027755444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDS5"/>
    <dbReference type="GeneID" id="38777249"/>
    <dbReference type="InParanoid" id="A0A401GDS5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="231" mass="24623" checksum="C99C79264533E936" modified="2019-05-08" version="1">MRSSIPSVLYHPPKAAQRRGEKMYIVFRGLALGPGVYETWDEVKAMCIGVSRSLYQQALIALLPPSAQLKQIPYDCTNIQLLSSVARTISGASVTLKSPIVASGGNSSSPASGLPSPTVPPLCTPSRSVLQSPGGRSAKPPTPLFECDMCKTHSGHFFSPYATIVSTPLSLKPLMQKAVGVELLREVIGRTMPVYEGEMLPPPILEPARTSQPVLPSLWTSPASVSFPPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEB6</accession>
    <name>A0A401GEB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611378.1">
        <property type="nucleotide sequence ID" value="XM_027755577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEB6"/>
    <dbReference type="GeneID" id="38777382"/>
    <dbReference type="InParanoid" id="A0A401GEB6"/>
    <dbReference type="OrthoDB" id="3220849at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8762" checksum="21EA0144254FC983" modified="2019-05-08" version="1">MAPDPPSFTKRPNNHLHPPPMTQNVNLTPAQVIAQAWNRESQESQEQWRMADAKARQQYTSPHVWANARKAASKGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEM1</accession>
    <name>A0A401GEM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0303060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611504.1">
        <property type="nucleotide sequence ID" value="XM_027755703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEM1"/>
    <dbReference type="FunCoup" id="A0A401GEM1">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEM1"/>
    <dbReference type="GeneID" id="38777508"/>
    <dbReference type="InParanoid" id="A0A401GEM1"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="86"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="796" mass="88720" checksum="78B77B1402FBBEC8" modified="2019-05-08" version="1">MTGSVHHHRPTLKQQNKAYKSKHATKGARKDAAKGRLARQSPKVSPAASAAAQARLNRRNNARQTQLRKRHSLVSATRLFSGPDGAPRIVAIVPLTEDVTAASVVEALAGPLDGVLLEACGGGSYRLRAERFKTSLQLLPLQHKRLYAALDACKAADYVVLALSSRVEVGCWGDTLLRALQAQGLPTVVPVVAAAAAPMDAKEKGGIMKSLLSFVRYFVPGAERIFDMRAPADALGALRALCEGRPAEAKWREGRAWVLGEHVEWQDGLLGVTGVVRGALLSADRLVHLPNFGDFRIAKIVSAPLPRTSRSAAGAMEVEPVLLAEPDVSSADSLVSTNDPDDLANEQTWPTEEEMRGAPAESAPADSLPDAKSSTTPKTVRRIPKGMSEYQAAWIIDESDEEGDDAEEGEGQAEGSTGEVEMEDVEEEEMVELRDDTEMETEGRRSVAFQDLDVEEEDRQLKNWRNRKREEEDDLAFPDEIDTPLDVPAQTRFQRYRGLRSFRTSPWDPYENLPRDYARIFQFEDYKRTEHAIRRRAEEDSAAIEPGVRVTVYLKDVPQEAAQQDSRSPFVLFNLLEHEHKKTVLNFTVQRNTEYDGSVRSKDPLILCVGPRRLRVNPIYSQHTRGGGKGYNNVHKFERYLRHGITNVATTYGPAVFGKQPCLLLRETDDPQSPELVAMGSFINPDPTRVIAKRIVLTGHPFKVHKKTATVRYMFFNPDDINYFKPIQLHTKYGRTGHIRESLGTHGYLKAHFDGPINQMDTVCMSLYKRVFPKWSDLWKEQSLPVSGSSVDAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEZ7</accession>
    <name>A0A401GEZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0304670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611661.1">
        <property type="nucleotide sequence ID" value="XM_027755860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEZ7"/>
    <dbReference type="GeneID" id="38777665"/>
    <dbReference type="InParanoid" id="A0A401GEZ7"/>
    <dbReference type="OrthoDB" id="2653987at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="24608" checksum="9966ECAACF6B9453" modified="2019-05-08" version="1">MLEKATDAVQNAKIYAKRQAVLAVVHLWTTRLALVSGITTFFVSMDSLLFSLSSVVTHVQDEEWSAVDKLTTACFAGALILHICSAIISFMGSFALVRLQLLDADQQEVEAGIPPEKALPLEFSELGRLWKATFDDVYSRVAFHRPLARRCSNESLLDPGPPVELLACCSALAVVMTGVGFILAVVGILTYVWTVTPLSIGIFTSACFGGCILTCGVVSFRYAILTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFL4</accession>
    <name>A0A401GFL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0306140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611806.1">
        <property type="nucleotide sequence ID" value="XM_027756005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFL4"/>
    <dbReference type="GeneID" id="38777810"/>
    <dbReference type="InParanoid" id="A0A401GFL4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="349" mass="39014" checksum="0C2C862856097884" modified="2019-05-08" version="1">MSRANETSQTILAPKPQLPAARFSPVLLWQANINMEPEAEAQAPTIQQDTPIGYYHHLGTIHNPIPVDSAEVFWSPERSPASEHDGSAHYRLVPPTTWDDTSPNPYSSMENTACTQRGACWAEYLSSDSSIYSGSPVALSPGSPYARMWNECDANSPLARNQGSVFVRSLKRGDDEADNATMSPEELQEDEQWFLDLRSFSHISQRRYDPRTERPPTPPYTHRSQRICEPVDPEREVWISVDARGIHEEAFNLEQRLSFLDDEMETGGYWPILIEDSPASTPASRSPMLPLQPLPPLSRAGESACDKSGDSLDELLRYAERYLASTAKAAPEALSVPWLLADEDIIRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFU8</accession>
    <name>A0A401GFU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-dependent rRNA helicase rrp3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0307910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611980.1">
        <property type="nucleotide sequence ID" value="XM_027756179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFU8"/>
    <dbReference type="STRING" id="139825.A0A401GFU8"/>
    <dbReference type="GeneID" id="38777984"/>
    <dbReference type="InParanoid" id="A0A401GFU8"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="65"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="239"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE81067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="444" mass="49133" checksum="F8EE90744C551965" modified="2019-05-08" version="1">MSRNAFWVLPAGAPTSPYPLQSAKSACPFSMEAKSFPELGICDPLLTALAKLEYTTPTQIQADCIGPALAGRDIIGLAPTGSGKTVAFALPILQRLWDNPQRLFACILSPTRELAYQISAQFEALGVSMGVQSVVIVGGEDRMQQAGFNLRTVKHLVLDEADRLLNPDFQSSIDGILKVIPRERTTYLFSATMTANVSKLQRASLTNPVRVEVSSHKYTTVSTLLQYYILYPLVQKEVMLVYLVNSLAQNSIIIFVRTIQNTQRITLILRSLGFRAIPLHGELSQSERSGAFHKFKSGSCNILVATDLASRGLDVPSVDVVINFDSPTHSKDYIHRVGRTARAGRAGKSILMVSQYDVEIMLRLEAAIGRKLELYATDEQEIALLRERVEEAGRHVANQLRDEAKTKGTSRKRRQTGDKADDKDREDMVEAGMSTSSFKKKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGU6</accession>
    <name>A0A401GGU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612320.1">
        <property type="nucleotide sequence ID" value="XM_027756519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGU6"/>
    <dbReference type="STRING" id="139825.A0A401GGU6"/>
    <dbReference type="GeneID" id="38778324"/>
    <dbReference type="InParanoid" id="A0A401GGU6"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11225" checksum="673937FD35176132" modified="2019-05-08" version="1">MASDFTGDFHPIWHPHCHLKQYRWSPSSSSPVSSLNTNIGSSLSDIYLVVNDIGTSSGEGLDFINGYAFLERLYKWFYSAFDTGNNRVGFAATSYTDATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH58</accession>
    <name>A0A401GH58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Staphylococcal nuclease domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0312210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612405.1">
        <property type="nucleotide sequence ID" value="XM_027756604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH58"/>
    <dbReference type="FunCoup" id="A0A401GH58">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GH58"/>
    <dbReference type="GeneID" id="38778409"/>
    <dbReference type="InParanoid" id="A0A401GH58"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="167"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="340"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="6">
        <location>
            <begin position="510"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="5">
        <location>
            <begin position="717"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="901" mass="99538" checksum="F1ED7CEB65F1DE28" modified="2019-05-08" version="1">MKAIVKSVISGDSLVLRGPPGAQGQPRKERVLHLVDISAPRLGTATRPDEQDWAFESREFLRALAVGKPVTFTTVHSLPPNDDVPRDLGSAEINGQDLASELLRNGWVRLKELKHDPTEEDMRKRDLENEAKAAGKGLWNPHGPKARTVHYAMPADSQEFISEWKGHSFDAIVEQVKDGSTLRVRLFMPEGDHQLVNIALAGVKCARVSSKPGESEPWAEEAKFFTECRLLQRAVRVQILSLPNAAATPFQIAASATPPPPASIFIGTVLHPAGNIAELLVASCLARVVDWHGGMLASSGGMERLRAAEKAAKEKRMYLFANAAAPSSKANGTMANGSSQTFDGTVTRIWSGDQISVADKESGKERRLQFSSTRGPKLADPKQAFYAQEAREFLRKRLIGKHVKVHVDFVRPREGEYEERECVTVRYGGQNANIAEQLVERGLASVVRHKRDDEDRSPEFDKLMAAEQLAVTELRGIHSGKDHPPPKQPLNISESHGRAAPFVNSFRRLGRIPAVVDYVAAGSRFKINLPKDNQVLTLVLSGVRAPRTARNPSEKSEPYGPEASDFAMRRLMQRDVEIEIHDVDKSGGFIGALYLNKTENAAITLVREGLATVHSYSADGLPWAHQLYEAEEEAKSTKRNIWKDYDEEAEEAPEVSPEDNAALKPDYIDVIISDVRTQNDFGFSVQILNTEGIASLEKLMRDFSLHHKVAATPPGFVPKSGDLVSAKFSDNSWYRAKVRRASPIKKEAEVTFIDYGNQDTVSFANIRPLDPKFSSLPGQARDARLSFVKLLGPESDYHADAVERFRALCEGRKLVANIDQREGPLLHLRLMDPTDPATEQAPSACINADLLREGLATIDRKGCKYLSAYPRLVKDLQAAVAGAKEDRLGMFEFGDVVEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIB5</accession>
    <name>A0A401GIB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0402470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612786.1">
        <property type="nucleotide sequence ID" value="XM_027756985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIB5"/>
    <dbReference type="GeneID" id="38778790"/>
    <dbReference type="InParanoid" id="A0A401GIB5"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="194" mass="20894" checksum="3445CF270EAB32EF" modified="2019-05-08" version="1">MNLTDIPHSGRQATIYRYTKDPLPTKAERVSFPVEHVYYCHSNEPSAAISSLSAYFLVFSCLTAAALAQTVWITAPAGYDSFSPGENFTVQITRPQEMSGADEVAIVIALESCAGWTGGCAEYDVTQVLGTVLYQGPYAPVFQTPGEAPYQNFTVQVPSYMAAGQASLSCSRFALLGGGLYPNLEVKNITLDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIE6</accession>
    <name>A0A401GIE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0403230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612860.1">
        <property type="nucleotide sequence ID" value="XM_027757059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIE6"/>
    <dbReference type="STRING" id="139825.A0A401GIE6"/>
    <dbReference type="GeneID" id="38778864"/>
    <dbReference type="InParanoid" id="A0A401GIE6"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF24">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019150626" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="4">
        <location>
            <begin position="212"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="310" mass="32243" checksum="780C77EB4C6BC2F8" modified="2019-05-08" version="1">MFHLFSVVFIALAAAFSVVGVAIPARDFAVRSTSAKNYIEERYSALNCGNKQRTSFFTACCGRWPANETLEDLPSGCFLESSSVSSAGPSGTQDLYNQCHCDDDPSSAPVPIPSASTSVVPPPVSALSSPVLVADPPASHSHSRHTHATTSSVPPSSCATPTSFPMPLSSLSPSPSTSLSLTPSLSKSSPAAVAASSDAFSSDYAVNWGGFATYYYQNGVAGACGTVHSDYNFICAMDQALYGYSGNASPLCGQQVLITNTDNGQSVTVTIADDCPTCRNSNSIDLSVAAFQAIADLSTGIVPISWQYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIQ6</accession>
    <name>A0A401GIQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0403610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612898.1">
        <property type="nucleotide sequence ID" value="XM_027757097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIQ6"/>
    <dbReference type="STRING" id="139825.A0A401GIQ6"/>
    <dbReference type="GeneID" id="38778902"/>
    <dbReference type="InParanoid" id="A0A401GIQ6"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="6"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="923"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="471"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="708"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="788"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="928"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE81985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="970" mass="107347" checksum="EFD944033B1A1F30" modified="2019-05-08" version="1">MASSTNIKVVCRFRPTNSIEQREGGEIVVSFSDNLQTVQLRSAQLGSGPEKDGFTFDRVFPPGTKQHEVFDYGVKDIVKDVLDGYNGTIFAYGQTGSGKTFTMMGADIDSAELKGLIPRITEQIFQSIVESDAHMEYVVKVSYMEIYLERIRDLLAPQNDNLQVHEEKSKGVYVKNLSDYYVSSAREVYEIMRQGGAARVVSSTNMNAESSRSHSIFLITIQQRNTETGAQKTGNLYLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALTDGKAKHVPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNEAETLSTLRFGIRAKSIKNTARVNAELSPLELKALLVKAQAANTSHQKYITALEAELAIWRAGGQVDQAEWATSDKPGATATAPAPKKIPASPTPSSVRSMTPVNPALEGLRSDLDSRPQTPTVVGLDKDEREEFLRRENELSDQLAERESALGAAQKLVGELKEELSFLKEQEATLSNENKGMSAQLNELRLQVERLDYDSKESVITIDILKEQNQDAKAELDELKKTITELKAVQKDASAEDKEKRKQEKMALMMAKFDAQGAFSEKDDQLRQILAKLDAIDSDAAVSSLSHNDITVLRRQLADGQVLIRETVDRLRQSQDESAMNARRRDELEARISSLETEYEELLEKTIHDEEVSNVDVAESIAELKNKLEAQYASKRDAHMGEVQDLKQQVEIKANEVRTLNATIDSLKSVNEELKRAFAVTSAGIEGGKNLAESAQDLERTRKAISVQLAEFDGVKKSLMRDLQNRCEKVVELEIQLDEIKEQYNNVIRNSNSKAQQKKMAFLERNLEQLTVVQKQLVDQNSALKKEAGIAERKLLARNERIQNLEALLQDADRRLAVQNQKFEAQLQAVKERLDQARAQKAASSPLSFGRIAKPLRGGGGAAANSTAAATSPSLTSNSANPLTRLQNEETGSGAKRASWFFNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJT8</accession>
    <name>A0A401GJT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0408150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613344.1">
        <property type="nucleotide sequence ID" value="XM_027757543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJT8"/>
    <dbReference type="STRING" id="139825.A0A401GJT8"/>
    <dbReference type="GeneID" id="38779348"/>
    <dbReference type="InParanoid" id="A0A401GJT8"/>
    <dbReference type="OrthoDB" id="2800500at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="324" mass="36057" checksum="047CE94C4146CCA2" modified="2019-05-08" version="1">MGLYPGTVKDPHTAFTFAVLDDFLLENKECKTVALNYYSKLKWVTSNAFPGTVPISVHMHSHGPTIHASSSPGPLSFSHDALCPVEKGGLAIFCPACPQPGLNLPFDWQANPVQWKFKRSFVMDGNFSAEHMKMKHPEEDVALSDGQAFMVSQEDYKAHLAVAMESHQHSTCHEHRAVNQANVDRANLDATGIRATACARHGFFVPHTVVDFQKGERQMNMDYSLSNALLTLTGITLVLVMYDIMCQYGVHVRKRFCHSAYLRMPFELKVDQGISLFHVHGHQDCCFQRFSPNFIVGAGMVDGKVIEILWAPTNEVSGSTRGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJX2</accession>
    <name>A0A401GJX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0408520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613381.1">
        <property type="nucleotide sequence ID" value="XM_027757580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJX2"/>
    <dbReference type="STRING" id="139825.A0A401GJX2"/>
    <dbReference type="GeneID" id="38779385"/>
    <dbReference type="InParanoid" id="A0A401GJX2"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="323" mass="34912" checksum="3DB8E33F878DF2D5" modified="2019-05-08" version="1">MSLPHPKAVPLVAPGHTRPVTHLSFSPLQDDGTYVLISSCKDGNPMLREWTGDWIGTFIGHKGAVWSSKLSPDTSRAASGSADFTAKVWDSYSGDCLHSFPHNHIVRSVAMSPSTSHLLTGGQEKKVRMFDLGRPDAEPDLLSDNGAALSHDGTVKSVVWVGDHTGVTAGEDGLIKWWDLRTRKLTTSLTFPGPITSMELSQQTNRLVVTSGKTVSFIPALLNGTQTHSLTLPYAPSSASIHPILQDRFVTGCTSDEWVRIHDVTGEERDVLKGHHGPVHCVEFSPDGEMFASGSEDGTIRLWQTTPGKSYGLWQGSHTNGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK25</accession>
    <name>A0A401GK25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dehydrogenase citC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0408940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613423.1">
        <property type="nucleotide sequence ID" value="XM_027757622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK25"/>
    <dbReference type="STRING" id="139825.A0A401GK25"/>
    <dbReference type="GeneID" id="38779427"/>
    <dbReference type="InParanoid" id="A0A401GK25"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019438540" evidence="9">
        <location>
            <begin position="21"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="640"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE82510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="691" mass="72052" checksum="776EF57839163F9A" modified="2019-05-08" version="1">MISLLGALLATLFLASLGLTFPTDVYHHHRELRARNIVYSGQIADAYDFIIVGGGVAGLTLASRLSEDANTTVLVLEAGDTGDAVSNQINTPGNTYYNGLVGSSCDWAYLTVPQPNVANRQLSWPMGKVIGGSSAINGMYLVRPSQIEIDAWAALVSPSDNGSSAAAYQWDNFFAALKKTETFTPPSSAIQQDADIQFNTASHGTSGPLHYSYPGFEFSQVGSWTPTLAAAGVIPNQDAYGGDGWGTFVATSAINPTNWTRSYAKSAYIDPLPPRSNLDILPNATVTRIVWSSSSSSNNVTASGVEYATSRGAPTTVVSVKKEVILTGGAVGSPHVLLVSGVGPSDVLSAAGVNVTVNLPGVGQHLQDHLSTQIIFTTHDDTAASLLPANAGNPAFMSFINSAVGYVNASILFDNVSDFQAGVVSSMSNALVPSTDPTVLAGYKAIYETTTNLLTTPVGQVEVLLNLVGSASGGTNTIGIEVGIQHPYSHGRLYINSSSIFDAPVIDPNYLSNPNDIVLLRQGLKLARQIGATPPLSTGLLAEVSPGPSVNTDDGWQGWLVNQIGTEYHPSSACSQLPLNLGGVVDSNLKVYGLGNVRVADSSIYPFAFSAHLQAPTYALGELAADIIRAYYNGTPAPGANATSTSADPTTSSNSTPSPSATQRVKSGATTLTASVSAVWMSLAASAWLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK43</accession>
    <name>A0A401GK43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phytase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0409220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613451.1">
        <property type="nucleotide sequence ID" value="XM_027757650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK43"/>
    <dbReference type="FunCoup" id="A0A401GK43">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK43"/>
    <dbReference type="GeneID" id="38779455"/>
    <dbReference type="InParanoid" id="A0A401GK43"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="630" mass="68610" checksum="611E73DA396ED422" modified="2019-05-08" version="1">MAVNGYSEVETTEEECKQYAPVDAERQSLLPSPEQENDGASSSKSALSSSLSANSLLHSRLQLSAAFAAGIVACLLIQILVSPQLWFPPPKGGNSGYSSSHAGMQAPPYAGSSEVHKFPPASPTNVFPSMFPTGVGHAGPTPTGAEPALIATAPSYPLHTGAAHLVSPDFTATSGNKSHFDIFRHWGNLSPWFSVGRGAFGVDSSPEAPETCRVTGLHLLHRHGARYPTEFASYGGPAKLAMKLHDAAAKWTAIGDLAFLNEWTYKLGEEILTPFGRQQLYDLGVSMRIKYGFLLKNFTESNTVPVFRTESQDRMLASARNFAIGFFGYPFEGQYQQSITIEDHGYNNTLAPYKTCPNADDPSKSDRGVDYVRQWAAIYLKDALARIAPQLDGYDLTIEDVYTLQQMCAYETVAIGYSRFCELFTEEEWKGFDYALDLYFWYDSAFGSPLAKVLGVGYIQEMVARLTHTPIETHNTSTNATLDDSTATFPVGQSLYVDATHEVVVLHVITALNLTTLAANGPLPADHIPRHRSFRSSHLAPFATNIQFQLLSCNSVPDAQIRVIINDGVVPLTGIKGCPDQKDGMCSIDTFVAGQKEIISETDWLYGCHGDWTVPPGPEWNTTIGSPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKD9</accession>
    <name>A0A401GKD9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0410070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613535.1">
        <property type="nucleotide sequence ID" value="XM_027757734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKD9"/>
    <dbReference type="STRING" id="139825.A0A401GKD9"/>
    <dbReference type="GeneID" id="38779539"/>
    <dbReference type="InParanoid" id="A0A401GKD9"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23815">
        <property type="entry name" value="UBCc_SpUBC14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="149" mass="16748" checksum="CEC28916B5B8B96D" modified="2019-05-08" version="1">MTSLRRIQKELTDITSRPIEGLSVEPVEDNLFEWKCAIKAASDSPYKNGTFHFSLSLPENFPFKAPSVTFTTKIYHPGINEEGHICVPVLRDQWKPSVTLSSVLAVIQEKVNNPSPDDPFEPDIAAQLKNDKTKFLATAKEWTKKYAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKG6</accession>
    <name>A0A401GKG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding TFAR19-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0410430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613571.1">
        <property type="nucleotide sequence ID" value="XM_027757770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKG6"/>
    <dbReference type="FunCoup" id="A0A401GKG6">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKG6"/>
    <dbReference type="GeneID" id="38779575"/>
    <dbReference type="InParanoid" id="A0A401GKG6"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="14746" checksum="76E9C15CA58DC4B1" modified="2019-05-08" version="1">MEDPELAAIRAARMSQLQQQNAGRGGGQGGEDEGKRVAEEQMRRDLLATVLDHAARERLARIALVSPDRARQIEAILLRMAQSGQLRGRVSEDQLIELLEQADEAQSKSAPKKGAIVFQRRKGGLDDDDFDLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKI1</accession>
    <name>A0A401GKI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0410680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613596.1">
        <property type="nucleotide sequence ID" value="XM_027757795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKI1"/>
    <dbReference type="GeneID" id="38779600"/>
    <dbReference type="InParanoid" id="A0A401GKI1"/>
    <dbReference type="OrthoDB" id="2758135at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="297" mass="33592" checksum="AF64B40845F7D33F" modified="2019-05-08" version="1">MLTLSPSLSRKKRAATPDDSDTLEGILVSDYYVGSPTLTQNVKWRRYKDMSILVRKDSDELAAELEWVGEIDASPATFYLYVCGKWRSGFFLHPSGKPQPFTNAKARGRIIAPTTSRWKKIISDYVWDSILEGFQRIQTSRSTEGAACRHTIVDTDGVKVRHSIFQPLDEEGREYPSNLEASMERWICQDAATQEELQDIIAEGKYEGQPLTVIGVDGRPILPKDYKSHLSGAIVHIKAGIVDQYFDSQNFDNYFADISEIRVLAPPAPPPQSPSKRRYQELLRQDAIACKRHRANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKK0</accession>
    <name>A0A401GKK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613616.1">
        <property type="nucleotide sequence ID" value="XM_027757815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKK0"/>
    <dbReference type="GeneID" id="38779620"/>
    <dbReference type="InParanoid" id="A0A401GKK0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="85" mass="8567" checksum="02E1D679EAB2BED9" modified="2019-05-08" version="1">MANRGPPSISDLQNQIRALSADVSQTEAIALKVQWAMEIICAALGINTGGASPSAPPSTVPPSAVPPSTMPPSSAPPFSNVTEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL05</accession>
    <name>A0A401GL05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0412270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613753.1">
        <property type="nucleotide sequence ID" value="XM_027757952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL05"/>
    <dbReference type="FunCoup" id="A0A401GL05">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GL05"/>
    <dbReference type="GeneID" id="38779757"/>
    <dbReference type="InParanoid" id="A0A401GL05"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="105"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="39635" checksum="AF5FCD4820BBACA9" modified="2019-05-08" version="1">MLHDDIRSAVFDSRELALKSHLSIPDPEFLPLIAQVPTIPLEDVKVLRDSQRKWNAQRRESLKDRLPAESAYRVEDHKIAVEDGEITVRCLTPTTGDAEERFPLLIWFHAGAFIFGDLDMDDYYLRIMCVEHHLSIVNVDYRLAPEHVHPIPWEDAYTATKWVVRNGSLLSASFEKGFILGGGSAGASLTVTVACRARDDLFFRETPITGQVLQSPSLLHPDGPVEEKYRSELLSMEQHKDGPLLTRDLIIAMAGMTKLPISDPRYTVLLQPSHTGMPPIYMQVAGMDLLRDEELLYAKLLDQAGVATRVDVYPGVPHFFHYFLPQLTISVKADKDLNNGIRWLLGLTDAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL36</accession>
    <name>A0A401GL36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0412700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613796.1">
        <property type="nucleotide sequence ID" value="XM_027757995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL36"/>
    <dbReference type="GeneID" id="38779800"/>
    <dbReference type="InParanoid" id="A0A401GL36"/>
    <dbReference type="OrthoDB" id="2747916at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="215" mass="24295" checksum="A3F410C45981A05D" modified="2019-05-08" version="1">MTHPLFNVLEEKVYFDLTDHFDNHRLKNIVFSPVKSGHSLCCIHLQLEQSPSTSEKIPSGILFEVMGQIAIQDCYLTTHGDSEHYPEPGDGSPAVSCWIEPLPDILSCADWRKAMRAITKIAEMGPESLLHLLRHVRMDPPSIDFMQLQVGWRPRASEDMIADFPLFNRKGKQTAPTSISEVPFGKPVQVLFTLYSVEQCGEKYLYAHLISIAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLB0</accession>
    <name>A0A401GLB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0413190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613845.1">
        <property type="nucleotide sequence ID" value="XM_027758044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLB0"/>
    <dbReference type="GeneID" id="38779849"/>
    <dbReference type="InParanoid" id="A0A401GLB0"/>
    <dbReference type="OrthoDB" id="3057274at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="658" mass="74589" checksum="6CE49DF387A415E2" modified="2019-05-08" version="1">MDPITVATTVFACVAFVKDMRELAQKLAESVEKVSDNRKKLRALCNNSVKHLVELEEVTRAHEADLTSRQLQDALTELRDELERIYRRCSKRIGHRKRGLPLVWSHLKSWKAADELEADILIFESNIRACEMRFLTTSMVRFEQNARLQAHSFHAMNAEQHSSMNQLVQAFRQSTFQEPQEVPYAVVLRQNTTDSVVHRGIVARPSALIHEPASTSFSPEYVSGAARSALCRRAPAEHHRFCRSQRYCSKAVRPHYFERRREERADHSRGAHTADPSVQIKDAILEISCTLKMFRSAPISATDCAKNLHSLATILGDLAMYASALMVLARSVSLYRDMHRKQPKAFAPYLARSVRFVALYRLKLGQYSAAKVASSEATELYRQAYADTLDDGIAADLGISLNIYSLVLRHKGQMHRADVLSVAEEAVCIFRRLADAREEFMPELANMLIGQARHFGDGGDFDKALECVEEATNLCRTTVQQSHVPFAQHRLARALFNYAHHLWKAGRTPECLQANEEAVELFRGFFSARPNAWRVEFCDALNNQAWFSYTSGLYEDALRLSQEAIPILRGVATTAKEYAVFTNILDTLAAVLEAMGRLEDSLATVEQIVHTIYDCPAFLKRSEQLIKALRWAARLLRALDRFQEAQQREDEAALEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLV1</accession>
    <name>A0A401GLV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0502300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614096.1">
        <property type="nucleotide sequence ID" value="XM_027758295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLV1"/>
    <dbReference type="GeneID" id="38780100"/>
    <dbReference type="InParanoid" id="A0A401GLV1"/>
    <dbReference type="OrthoDB" id="3124804at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17606" checksum="3C05057B1D70549C" modified="2019-05-08" version="1">MASLRQLTRVTLARTVTTPTIDIPRDISTHEFKGIVTLKEADKKEVIENALDYCVEAGFDDMGADHAIIAYVTSLDLQLSFDNVGITHIHSAGGNHVNPNDKVDTFRRATVQLFDKQRQPMRFQGSDGRIYDRIHIPADRALWPRFCNGYYTRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM01</accession>
    <name>A0A401GM01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0502740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614140.1">
        <property type="nucleotide sequence ID" value="XM_027758339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM01"/>
    <dbReference type="STRING" id="139825.A0A401GM01"/>
    <dbReference type="GeneID" id="38780144"/>
    <dbReference type="InParanoid" id="A0A401GM01"/>
    <dbReference type="OrthoDB" id="3261666at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="367" mass="39999" checksum="25EE1A01190894CF" modified="2019-05-08" version="1">MAQPIIYRTPPIAGRPPFATDEPDSMYQQHPATVRVRQQPPPDPNARTSAYNMYDHYLDDSRGPGVSGQNPFDDSMEYKGPRMQMQPQQQPIPLASPKPGYAAPIAALNLAQPSRVAAPDGRQTASPEMSQLQFPKPLTLVARQGTPSIPSTPHPLQPPMTPIEPAFIRPFNAPATRDVKFAEVQPILRGNGEETLLPRRGARQGEEFWRRFSMIAKEDNRKPYAQKQSAWLKKTVTGSSRMSRWVLIMGMILLVVIIGAICLGVYVAHKSTSPSTPTAIGGSADETGHIATTAAAIAGVHGSSATSLHVTPTNTVARRDSLVPPVPTSFALPVPYPPAEFGGHAHLLRAFPPSRHRRRSYLNRTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMD9</accession>
    <name>A0A401GMD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614265.1">
        <property type="nucleotide sequence ID" value="XM_027758464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMD9"/>
    <dbReference type="FunCoup" id="A0A401GMD9">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMD9"/>
    <dbReference type="GeneID" id="38780269"/>
    <dbReference type="InParanoid" id="A0A401GMD9"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="518" mass="54882" checksum="EBDB227A255B915F" modified="2019-05-08" version="1">MGKYPDLYEASIAELQDGLEKGIFTSVDLVNAYLARTEEVNLKGPALHAVIETTPNALEQAAVLDNERKTSGARGPLHGIPILLKDNIATLHSQGMNTTAGSYALLGSVVPRDATVSAMLRAAGAILLGKASLSEWANWRGEVPSGFSGRGGQCISPYVSLGNPSGSSSGSGVAIAIGLAAGSLGSETDGSIISPSSYCNIVGIKPTVGLTSRAGVIPISEHQDSIGPMCRTVADAAVILNSIVGRDPLDSYSLSQLEIAPDYIQALQADGLKGARLGVPRKLFEKADVNIIAAFNATLDVFRELGATIIDPAEFPEYDNDAIAQRETIVLRTDFKVNVKQYISQLVEVPTGVKDLSDLITFNKEHADIELVEPYWKDQSTFIKSNETTPDQAFYDALAANTAMGRSGGIDGALKQYNLDAIISPTSDASKPAAIAAYPVITVPLGFQPHDVLLSDAKPTRAIGPNMPFGISFLGTAYSEFSLIKYAYAYEQATKTRLKQLAYSEAIPKTQLGDVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GME1</accession>
    <name>A0A401GME1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0504590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614324.1">
        <property type="nucleotide sequence ID" value="XM_027758523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GME1"/>
    <dbReference type="FunCoup" id="A0A401GME1">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GME1"/>
    <dbReference type="GeneID" id="38780328"/>
    <dbReference type="InParanoid" id="A0A401GME1"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="266"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="48480" checksum="1A9CEE60349AF688" modified="2019-05-08" version="1">MSSMDLREPSPSDASDALSEFLSRQKERYLDAVARGTAGEWTVVMGNEAGDLDSLASAIAYAYYAGVVSKHAPTIPLVQTPREDLHLRAENLHALALAGVDPALLLTISDLPSSSSSSPFPSTKFVLVDHNRLAPAFSHPSARVVAVVDHHADEGLYADTADPRLIEVPTGSCASIVARLLQHTGMRIPRELATLLLCSILVDTGGLKPGGKAEDADRAAAAFLAPLSTLSLTCQNEALIQTETQITTQDASSEELHAVAPIQALNATLQTRKASVAHLGTRDLLRRDYKEYTYTLPRGADVCVGLASVPVGLHAWLSREPGGAFGTEAEAWMRTRELDVLGVLTSFRDAESEHSGKSGRGKHRREQLYVVRDKALAETLFSGLEESEELKLKRRKWKDYDLTKEKVGFGGDVAVRVWKQKNVDATRKTTAPLVKSIIEGEGRGKGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GML0</accession>
    <name>A0A401GML0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0504680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614333.1">
        <property type="nucleotide sequence ID" value="XM_027758532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GML0"/>
    <dbReference type="STRING" id="139825.A0A401GML0"/>
    <dbReference type="GeneID" id="38780337"/>
    <dbReference type="InParanoid" id="A0A401GML0"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="308" mass="34002" checksum="044F6E362E52DBE8" modified="2019-05-08" version="1">MMEGLPIDTSHPAVRDYLALVRLQVLTPLSLLINIATVMVCSLVVSPSLGSISNLYPASISPNPSMIAIYITAIYIGQIGYCVLLVLARKPETKKALVKGVGLPLVLANWVMAGWAIAWVLQAFLVSTVLQGILLVLLLYANAVLLVYHPPTTSRPFDMALIHAPMRAFLLWPLGVMFPYSLFITLGFTWTPGEPQHYARHQWAGFSVMLGVNLLGLVVDVFQRDIVWCVAASWICASIWSLRPKPFPVFITVVLFTIIHPLALVASALWVRLRGRHPNGAIALPPDEEQSPREERPPREVDTDALWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMR1</accession>
    <name>A0A401GMR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein A family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0505700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614430.1">
        <property type="nucleotide sequence ID" value="XM_027758629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMR1"/>
    <dbReference type="STRING" id="139825.A0A401GMR1"/>
    <dbReference type="GeneID" id="38780434"/>
    <dbReference type="InParanoid" id="A0A401GMR1"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="135"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="319" mass="34568" checksum="95DC1546E84B6E4D" modified="2019-05-08" version="1">MSLSPDHPRNLPIPLRSAMKHSRPNTPSCQSPPSPGLSRSSLLPSPTPLPAGSPLLDVPSATTSPGIPSPSSSSSPSAIFVTPAPYAGSPLVASQGYTPKVSFDTLENPAASMFSYTLHVQSDGYSRNRGTRVFLCASSPDESGTQALDWVLDSLVQDGDELIVFRGVDSEELSKEHEQYREDARELMHHIQEKCVEYDPDRKLSIIVEYIAGKVPQAIDRLIALYRPDSIVVGTRGQRSMMQAWGAAFGAPGVGSISKYCLSHSPVPIIVVRPESKVRKTRAKRRADPKRGSHFEEWTNARSHGGSGLPVPMVTSMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNG4</accession>
    <name>A0A401GNG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0503320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614197.1">
        <property type="nucleotide sequence ID" value="XM_027758396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNG4"/>
    <dbReference type="GeneID" id="38780201"/>
    <dbReference type="InParanoid" id="A0A401GNG4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="245" mass="26933" checksum="39BEF603A56EAE5C" modified="2019-05-08" version="1">MARGMLVDETLDVEPVPKLLDFDNSPPAMPGRWRALVIDSPGTTPVRSQVRWLNSPSASPPKRRPLLDDVLSPLPPSSAPSHSPARTFDDSNFRHDAPVIHYMKGSIEPVTVTSRMPSLAALPDELPIHHPTHWEQVPGLFPDTTQLLPMAVPGETNATSGSQVARLGRSFAQIAAEADSSMDDDEGDSFAVSHHCAMLRECIVRLQRELNLTEDMHVANLNASSTMFQMGYILRDIHGEAYRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNK0</accession>
    <name>A0A401GNK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PIG-P-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0508420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614699.1">
        <property type="nucleotide sequence ID" value="XM_027758898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNK0"/>
    <dbReference type="STRING" id="139825.A0A401GNK0"/>
    <dbReference type="GeneID" id="38780703"/>
    <dbReference type="InParanoid" id="A0A401GNK0"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="6">
        <location>
            <begin position="30"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="167" mass="18437" checksum="C4CA276048D0D3F0" modified="2019-05-08" version="1">MAENNPTSPIAPLAPYPPLPPTESRSRAPEFYGFVAWTSTYLLFSLYLLWALLPDEYIVWLGVSWYPNREWAVLVPAYSVAVVLLTYFTYFALAFAGTPAFSDISTITDSKAHLPPVDAPNPYLAHAQPGVIPEMYDIPIGLVNRVVYGGARPQRRAVEARGDSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNV7</accession>
    <name>A0A401GNV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614816.1">
        <property type="nucleotide sequence ID" value="XM_027759015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNV7"/>
    <dbReference type="GeneID" id="38780820"/>
    <dbReference type="InParanoid" id="A0A401GNV7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="158" mass="18455" checksum="367C5F1246337DD8" modified="2019-05-08" version="1">MGIGAFPSSHPSPPIWSICVVITLEVTVIDEAYCFRLLRYRDLNPIHLLRWLSIQPHRLVALRRAKAFTSLAHLRAEPALHLSWIAPRNILSDLIFSDEFTRTHPSRAWRLSCDRCALFSLGDEKFEGETRDWFVPMLHYTCEHVKNRLLPHPSLRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPC2</accession>
    <name>A0A401GPC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614979.1">
        <property type="nucleotide sequence ID" value="XM_027759178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPC2"/>
    <dbReference type="GeneID" id="38780983"/>
    <dbReference type="InParanoid" id="A0A401GPC2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="213" mass="23554" checksum="313891DFA8F34D0D" modified="2019-05-08" version="1">MDAGSSTGHGLPAILQIMSSGVLPTSSDMVQAGALAVGRQLQTPGPYPSLLQSQIPLTAAQYLAANLAHFQCAPSYLTPVGRCTLANVYLEYLFNVYGSTTNQIVNDMLAFFHELERVSACGGTYTEQPDVQFDVSNFCIHTVIIPVMYFINEYLRLRYDECLVPGQNRQLVECQYRSPQGGNISKDKKVFVMQFSGIMGQKSLVLFMQKARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPH0</accession>
    <name>A0A401GPH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614962.1">
        <property type="nucleotide sequence ID" value="XM_027759161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPH0"/>
    <dbReference type="STRING" id="139825.A0A401GPH0"/>
    <dbReference type="GeneID" id="38780966"/>
    <dbReference type="InParanoid" id="A0A401GPH0"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="125" mass="13863" checksum="80A9CEDA4EB5328D" modified="2019-05-08" version="1">MRRYSDRLQPIRTRSSSVGTTNNSRTEYRPSMADVTYNTSFPSLIRTLSALTGVHCEQPVECSCETGVATQSKSPLILLEYNERDAAERTLWNMMCEVGIKFEQVGEKVGSGGEPAEIWVGSVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPR7</accession>
    <name>A0A401GPR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methyltransferase gedA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0601910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615126.1">
        <property type="nucleotide sequence ID" value="XM_027759325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPR7"/>
    <dbReference type="GeneID" id="38781130"/>
    <dbReference type="InParanoid" id="A0A401GPR7"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019586200" evidence="4">
        <location>
            <begin position="22"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="76"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="259"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="451" mass="49537" checksum="5C1C1B47DF3C010A" modified="2019-05-08" version="1">MAATSARAKELLALVALVTDASQIMIQEWAKEDSSVKAGEQDTFSSAALRNAQRTIISTCGSFTELAQVPQKRLIEVATEFSEARALHVVAEHRIADHLSAVDQKLGMPISELSKETGLHPQKLSRIMRNLCSAHIFAEVREGCFSNNTVSAALVNNEYLRAYILVVSRESYSASVKLPQVLADPVKGWSTSATCTPFQVAFGTDLAQWEWLEEGEVQPDGTVKPRPSLELFGLAMAGGDRILGTPPSYDFPWESLGSGTLVDVGGGVGGMCMDLCKQYPLLNFVVQDRAPVIEQAYSLWEDEQPEAFKSGRVKLMPHNLFTENPVVGADAYVLRHIIHDWEDNRCVDILSALRPALSERSRVLIVDKVLNTTLGCPELPSAPFPLLANYGNFARAAHELDLLMMTLFNGAERTPAEFRVLAEKAGLVVTRIWECPGMDYITEMRLPSASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPU8</accession>
    <name>A0A401GPU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0601570</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615092.1">
        <property type="nucleotide sequence ID" value="XM_027759291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPU8"/>
    <dbReference type="FunCoup" id="A0A401GPU8">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GPU8"/>
    <dbReference type="GeneID" id="38781096"/>
    <dbReference type="InParanoid" id="A0A401GPU8"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="339"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE84179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="635" mass="68702" checksum="50F6EA976F8065C8" modified="2019-05-08" version="1">MVASTIVSPSFPSGLDLAAATLSAATTTKSSSAPTPASLALDLDVIILGVVALFILFALPGAVTRSLHRSEWSEGHLFRSVVVKALRHSFVLNPKLSLVAPTYTGQSSRAEKGALQSDESNTYTSHAHLVRDPYSGGGRRRKLDPPAHMPSWSTMLPGVTSIFKIAIRPGLSVGKAVILALYFGLVVGFGLYRSNPFVDFNQSAYIATSQIPVVIILAAKNNMLGAMMGYGYEKLNYLHRFAGYLFVLGVNVHAIGYFYKWSLAGTLLKDLADPTIAWGFAALLAADILVLFSFKFIRDKFFPFFLASHVICAVVLLVATYLHEQFLWPYIAVAAAYYGLDRIMRIVKTRYSTARLLVLSDLNMVRVEIPSINAGWRAGQHLRIRVLSTGMGWFGWAENHPFTIASVSRSPGEEGLVLLCKKAGDWTGRLVELAKRAEHSEACEVHTRVKVLVEGPYGGHGHAILPSYSGAMLVAGGSGITYALSTAQELMQKEAEGSSRVKVVELVWSVPDPVCLEPLLPLFSSMLAQAQSSTTSLRISVFYTRAPTSPDAFKAFHSLPQGLTLAPGRPRLSKILDSVMDRTISHVGKGHKCTGVALGVCGPLELAEEVTSTARSVHADKRQAMGGVEVHAEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQA1</accession>
    <name>A0A401GQA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615295.1">
        <property type="nucleotide sequence ID" value="XM_027759494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQA1"/>
    <dbReference type="STRING" id="139825.A0A401GQA1"/>
    <dbReference type="GeneID" id="38781299"/>
    <dbReference type="InParanoid" id="A0A401GQA1"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="177"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="445" mass="51364" checksum="658C4CBD942A72E9" modified="2019-05-08" version="1">MLDFNYINPTALPEQYREHLPSQAEWSTERNAHFIGGRPVFIRPDNHNFDYSPEEFERTLPHNLGGIVLQHIADSGITTSYPGERPDAPWNLPAQNPVPQPTLAPIVPDYIPPMATVTIDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRMKEGLCFLCRKKGHIANDRQFHPQSGSFTRARMIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR89</accession>
    <name>A0A401GR89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0606490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615583.1">
        <property type="nucleotide sequence ID" value="XM_027759782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR89"/>
    <dbReference type="STRING" id="139825.A0A401GR89"/>
    <dbReference type="GeneID" id="38781587"/>
    <dbReference type="InParanoid" id="A0A401GR89"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="149" mass="16866" checksum="DE82605FA448D266" modified="2019-05-08" version="1">MEARVGVGVFVLNDEGKFIMGRRKGSVGAGTWALPGGHLEFGESFEACAARELLEETGLAVGDVHFLTATNNVMEDVGKHYVTIFMQCRIIGEKTQPEIMEPDKCEEWEWASWEDVRSWEASGQDDERKLFQPIHNLFVQRPLFRPAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRF2</accession>
    <name>A0A401GRF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0607100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615643.1">
        <property type="nucleotide sequence ID" value="XM_027759842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRF2"/>
    <dbReference type="STRING" id="139825.A0A401GRF2"/>
    <dbReference type="GeneID" id="38781647"/>
    <dbReference type="InParanoid" id="A0A401GRF2"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-specific glutamate dehydrogenase second" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-glutamate dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="221"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="392"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="466" mass="52851" checksum="562442B869A6454D" modified="2019-05-08" version="1">MWNVEMCYGPVIEVFEVEGSCECRLVIGYKMGGTSKFFSALSNLYHFYALYSMCKYIEQFSNGITIISLYLNPLPSALNAPTIKHSIFQVMKEASLLYCLPDNPFFYAEPGQNSGHAVQEATYAYCGWVFMQHFCNHLGPAYLALKNILDESNSSHMEVLNNIKHRFREETFMRESIAQVIHAHADLINLLPTLSYQRLQTQVPLSDEDLYDKIRKTVHNKHELQVLESFLIFNKCIQLPHVLKTNFYQLTKVALSFRLVPDFLPEVEYPKKPFGMFFIIGGEFRGFHIRFRDVVRGGIRIVMLRNSELGSSPRLCFEKYVDAVINLLIPGQSPRIKKCLIDLYGKPELLFFGPDEGTVDMMDWAALHTRARGAETWWKSFTMGKSTETLSGILHDQFGMTSLSIQQYVLGIYKQLGLREKDITKVQTGGPADGDLGSSDSDKTIAVIDSSGVLADPAGIDHEELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRF3</accession>
    <name>A0A401GRF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0607870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615720.1">
        <property type="nucleotide sequence ID" value="XM_027759919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRF3"/>
    <dbReference type="STRING" id="139825.A0A401GRF3"/>
    <dbReference type="GeneID" id="38781724"/>
    <dbReference type="InParanoid" id="A0A401GRF3"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="744" mass="80518" checksum="C42F11D377007859" modified="2019-05-08" version="1">MTVPEPFLRDANVGSADPAMIDHHDPNDAEKIHGGSKLSTSENVQEKKKEDFLDQIVPAVDYEDEDEGDQIFGTDDPFPMDPNAPEEQQFTFRAVFVGCMLGAVISASNIYLGLKTGWTFGASLFGSIFGFAILKPLSKALPERFGGGYFGPKENVCCQSAATAAGSLGLLFTSGFPAAYQLGLLGANPQADFGRIITFTLCCAYVGIFFTMPLRRLYILKLKLTFPGAVAVAYTIRSLHVGRNAAANARKKTWGLIISFFISISWRVASEYAPGIMWDWHWAYWFYKAGWKWIICAESWGWIFELTPAFIGVGLLVPMTASVSFFGGSLLAWAIIGPALITTGKAVGVAISPHYPGYINYANMLLDDPVHSPSPKYWMIWPGCWLLLCASMAEIGVNYKPIFVSISLFLSPLINRLRPGKSVQLNKEDGLYDPTPIEEQTPWWLWIGGLTISTILSMLIMRYQFGQNAGVTFLAVIFSFIFSLVGAECTGRLDITPVTTFGNFAQLIFGGISKGAGMAPAVNQLNNGLTGMITLAASEQCSDMLGDLKTTHLIGASPRVQLYAQCFGALVSIFLSAGMYLVFVKAYPCINELTATTCSFPAPDVGAWRAVSVAVSSPSLPIPLSSGVTALCLGGFAIVQTIVKYRYFSPDKHKWFPNWNAVGIAMILGPLCTYPMAMLFGSTVALVWRRYWPAVFMMYGYSAAAGMIAGEGLGGIINAVLQIAGVSGSVHGTSVGCPMGEYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRR8</accession>
    <name>A0A401GRR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615819.1">
        <property type="nucleotide sequence ID" value="XM_027760018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRR8"/>
    <dbReference type="GeneID" id="38781823"/>
    <dbReference type="InParanoid" id="A0A401GRR8"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20535" checksum="6916E5BB15A72051" modified="2019-05-08" version="1">MSKFAPHPRTANQPRADASTVCQKCLGTGHFTFECKSTRPYISRPSRTQQLENPRVLAKLKVDGKPSVEVPEEFKSKTGTANRILEAKEKARAQETEHKGDVSSSKKKRKHSSDSESNSDSDSNSESESDRDSDSDSDSTSSSSTSSHSGSNSDSASSRRRRERSASAQRKSRSRSPSRSRRRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSJ9</accession>
    <name>A0A401GSJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0703730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616100.1">
        <property type="nucleotide sequence ID" value="XM_027760299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSJ9"/>
    <dbReference type="STRING" id="139825.A0A401GSJ9"/>
    <dbReference type="GeneID" id="38782104"/>
    <dbReference type="InParanoid" id="A0A401GSJ9"/>
    <dbReference type="OrthoDB" id="3046149at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="174"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="319" mass="35381" checksum="D96F7BB93FDE433D" modified="2019-05-08" version="1">MSDLGAVSLSEINDTFGVLLLGLIFTVTLYGLTFFQTYFYYSRFSSDSIWSKCSVGMIWAMDTATTALLSQTLYNYMITNFVVPFNQLDMTKSFVAESGISSFGIFAVHTFYAVRIWKVNDRNPIIPGLVLFFSVAGFATGLVGTALISMRPLFYNFVAGEVEIASIVQYGIYTACDLIILISLFCSNGIIVMKAPQNAYEYIVVNFLIRGTCFTVLQIVCLVTFIAKPTHQVWIFFHFITSKVYANSLMAMLNFRDAYRGRGVTDVHSAQFTSKANGTLTGHGPAISHEMQLNMANSDGKPSALMTMEPSEVHSVNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT69</accession>
    <name>A0A401GT69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616319.1">
        <property type="nucleotide sequence ID" value="XM_027760518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT69"/>
    <dbReference type="GeneID" id="38782323"/>
    <dbReference type="InParanoid" id="A0A401GT69"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20027" checksum="03428C10B246A08A" modified="2019-05-08" version="1">MGSPNARPADEAPASICPFAVWSSHVPQVFMVQAQSEAASVRIILPLPRDIPVLAQVEIHLVTARTVEAGCWMVPQIANHLPAVIPRGLTAHILYDDPAVHEDFGLGHPPNGLPDIGTLHLWVETLRNAARELYDVMRRITGRCELADGTLRQLQIVVKELEIAFRLVVFPPPITSFQLLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT87</accession>
    <name>A0A401GT87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616303.1">
        <property type="nucleotide sequence ID" value="XM_027760502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT87"/>
    <dbReference type="GeneID" id="38782307"/>
    <dbReference type="InParanoid" id="A0A401GT87"/>
    <dbReference type="OrthoDB" id="3235325at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="547" mass="59410" checksum="AE4AF6DB13152F5C" modified="2019-05-08" version="1">MEIHALNAREQILKETYSKLVEAVPQAVLLMNSEPSQPSNFPGSSDISGPRALSFSTSGGAPLCKSDYPGVRFWMFDEWNTYRKILIMEGGILQIPESINADHSTDEQQESEDWRSKKPNATKKKKTIRRALYLEDEHGETVSDNRAGEIRRVAREIWAQLWNEGHAPETWGAKTANVAAFYYKQMSLRCPELRLCHGDWKAERLVIDSYSQWRTTRSKGDEMKSASWSRSRAHSHAHSKCKARSASDMDSSKDDSQPTKRVKATMSSSTPSSNSISISNPTPDTVHSRESANPAVNVQSSSSSAVALISAIAITPAESGSPVANENDEELEYIDASLGLAGSACDPTTASGQRDDTDPGTHERQQTPIASTLVPTTARNPTNSMPLDPLADMFDMTPATAQTATTSTSAATVIPPASELPALTSSDIVMDSVRTAVPTMQPKKKKKSPKMFANSSSTASNLFAKDWLKTHEGESQEQFQSAWEALKSAERKMYEDRSAATIAALKAEKAAAKRAEKAAKVSGKKKAGQVTLPASAGTKKVLGSIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTA7</accession>
    <name>A0A401GTA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616322.1">
        <property type="nucleotide sequence ID" value="XM_027760521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTA7"/>
    <dbReference type="GeneID" id="38782326"/>
    <dbReference type="InParanoid" id="A0A401GTA7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="109" mass="11477" checksum="87F8CC2D290DC78E" modified="2019-05-08" version="1">MTTDGQTSLANPGPKGVHDSTLALTQHLATLLATSPLRTPGKYPDTNHGYDNTAPIYPLSGSVYSDSEDLGFPFCSYALPAAITPLSEPAPKNAPVYDAWGPITLDALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU27</accession>
    <name>A0A401GU27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 69 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616630.1">
        <property type="nucleotide sequence ID" value="XM_027760829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU27"/>
    <dbReference type="STRING" id="139825.A0A401GU27"/>
    <dbReference type="GeneID" id="38782634"/>
    <dbReference type="InParanoid" id="A0A401GU27"/>
    <dbReference type="OrthoDB" id="3235770at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF2">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="594" mass="66839" checksum="F7C77E967E0AEF07" modified="2019-05-08" version="1">MAFVLRRRTFIRLLLFIAVLLLVRLFVVSPSPASSVASFYNSDSQEIRKQNVLDLVTRSDKVLDVKKHKFLQARIGRDERDDLFAGIIRDGVQDHWERFQKPYILGHDTSHIDEQAVFSSIEQLLTLNGWVAALCPTLTRPFGQNKYEDAYDDLARQDRFYYIGMVIHSADHFLVDQLAVIVQLAKRLGTSNIFVSMLDYDSSDSTATLTDLCEAVLTLLGIPFRIRTVPGMTEDPIAAYYPLEEAYARNLVLEPLHELYERRKIKFHRVIWLKGFTCPNDILETMRLSVANEAAMVCGMDWAEHNGFFIFSDRWRTRDINGDQFRQSKSSSISTSPLTSVPPRDAVGAQRYTQHLPFQVFCCESGTHVVDPAQSYYTGIAYRAGTDFHNASTSADPPVRGPEARCLDSTQAWFCRDLWVSKAREGIRSIEPEFEADEKPTTRAEKRAAVVPDPDEELAPRQPAKEDLDANAGSDYDASDLPLADPPPAESPESGRLTIPNADFLAARVLVNPRCVTTYAGVSHTQLALDLFGPPDREDAEDPKGNDIIDEWEGAPDTFVCQEQQRTGGRRAPKTQRRLSFSIHAELEESLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV40</accession>
    <name>A0A401GV40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0806120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617001.1">
        <property type="nucleotide sequence ID" value="XM_027761200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV40"/>
    <dbReference type="GeneID" id="38783005"/>
    <dbReference type="InParanoid" id="A0A401GV40"/>
    <dbReference type="OrthoDB" id="3269308at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18130" checksum="07A8ECE641348EE7" modified="2019-05-08" version="1">MLHRSLDLYPLLIVDNKPATVWLVGEVDSSWFKLRGEPLAVVSIKIGSNTSDVLKASRFQSTGSGEYASVEAFQDVFDADTKFGPRNTMRQMHATDIHKNDLVLVECNVTHWRVDAKGKASYEKGWTKWRTGFELVTIARLYDGPQEIRAVVPRAEVSSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW67</accession>
    <name>A0A401GW67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium channel YVC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0903190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617353.1">
        <property type="nucleotide sequence ID" value="XM_027761552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW67"/>
    <dbReference type="STRING" id="139825.A0A401GW67"/>
    <dbReference type="GeneID" id="38783357"/>
    <dbReference type="InParanoid" id="A0A401GW67"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="249"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="90498" checksum="CA59FFA43E6990FB" modified="2019-05-08" version="1">MSEAAPERQPLLRAADVDTTEVYPIIQLIREDVMHNIDIALSYEALIAPEVTINLILPLEEKYNKIQRQGNLSIVFCLLLNRVYFIRDTHLSTAPLSRTRAALCEILAIRTLREHAHNMLELALAVTMSWPVYSGAPPELLQRAREEREEDPEERVGNAIEMAILGQAKRFTNSSACQKWKDCVPSGQQSFNPLGCTFAVTPGALSLILHLQTYKRTPIHFYDPYKAPLLDHYRLKVPAIRSVLEYTNFLVMFVLFIVALEFNTMGHINVAEGIFMIYALGFTLEKVAAMQEHGITLYFKGTWNGFDLAFVTLYCAYAILRLVGVYNHRHWARELGIDFLALIAVLMFPRLAFVTLKNNVMVLSLRAMIVQFVALMCVAAFCFGGFMYAIWTFSRNKAGYSASQVAWWMLDLWFGLDASLFDAAAAIHPWLGPVTIVTYASLSNTLLLTILVSILSHTFSTINDDASAEAMFRRAVSTIEGVKADFLFSYQPPINLVALCILLPAGYILSPRWFHKLNVFMIRLTSFPVLLLIAWYERQAKRSGSFTFYETVSAAAEKVFDTLPRHLKRLTFFEGLSGPDADIDAIFELEDEFEESALDTVEEPTSFAGLRPRRMSHGSRRPTVGRSTPPRSSRKSEQQQVGHPSGPSSSRHRLNSIVTHWEIPQSVSSPLAQIYQPQSTEENFADGQDGVSPSVSYGRRRLSSLHQRSTMDLSGGPGHHATAFKRFPTTSPGSRSGGLSSQPLSESPGQRSDMRSHTSLEQPETAEQIEESQPQAGIQRRLDTIEERQKRIEDLLVQLSERVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWV9</accession>
    <name>A0A401GWV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0905390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617572.1">
        <property type="nucleotide sequence ID" value="XM_027761771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWV9"/>
    <dbReference type="STRING" id="139825.A0A401GWV9"/>
    <dbReference type="GeneID" id="38783576"/>
    <dbReference type="InParanoid" id="A0A401GWV9"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="389" mass="43073" checksum="3E9D1046A66530DC" modified="2019-05-08" version="1">MLTRSADRKTRSSAKGAKAGGNNKAVSRSVSSRSKPPETRQTRKALDDDARPSKKPRITKETVIAEIANSGRSTRLTEPDPPAKKSTGRSSNSSIKERSTGKGYTTKAPDTSSVRKAALPVGGSSGGRNDTRLRKLEEEFEQKQRSLKRERDEFEAEVADLQKSQDSVDEREKAVTKKEEALARTEAKLNERDAAVVKREQEVAGLVTSVTSSRAEQALAQLEESFTCALCFDVMACPYTLTMSQCGHSYCAVCILKWFFSHLHYECGSWHEILECPLCRTSLPMPRDGLRSIFSCPFSPNRMADKLLTDFVDVLHKSGPAVGTSASAKKKQKAAETGDPTAAWHEGGSARAEWEERERKGRDEMRLLTANWAKLQRLDFKAIRDRIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX85</accession>
    <name>A0A401GX85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1000880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617759.1">
        <property type="nucleotide sequence ID" value="XM_027761958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX85"/>
    <dbReference type="STRING" id="139825.A0A401GX85"/>
    <dbReference type="GeneID" id="38783763"/>
    <dbReference type="InParanoid" id="A0A401GX85"/>
    <dbReference type="OrthoDB" id="3256901at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="517" mass="57464" checksum="0DCB295DD26E10C7" modified="2019-05-08" version="1">MVRETVRNKPTVKSVAASAIPEPSSKVKSNVSESREAAQPSSSKTADNEARMYSHFMSLGAPEVGEQEFGRLCRGPLADALLFAAEHVKGRSETASARVAIQSMRETGKNKHVDTAESSYLRARHANARTVCAKNDYESMQATLNDFSKSVAKLENEVYHLQKALENKRMTIFLLKILKRKENMHSARFAELIRLLEDLRENAPPKSGFEKLDAESNDSPPYKPSPSFSLGTRVEPTRDVLAALRAHHVQLSRFSKYSANSASTGTAETRLLKTLASAMKLPEDNVQVIAGYTKCLKLAKIRARENLQYQSPLDPKSTSEADDINLDAVLKRVIHKENNVQHLSDSAVALQWSCGRAVQSISAFVETTIPELRESLREEASVTEGYVDALRLSVVNRAETSTMTYGSADTGSPYQHEGKAWHRTLEEVQTAIEETYAREQFLRRATLLDSSNAHQHEHRELIATHMELQAKADERIGNLLARKLEKARVGDVLTRDVEQLATEVKIVASLVSPSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXD7</accession>
    <name>A0A401GXD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Elongation factor 1-gamma 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1001190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617790.1">
        <property type="nucleotide sequence ID" value="XM_027761989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXD7"/>
    <dbReference type="FunCoup" id="A0A401GXD7">
        <property type="interactions" value="607"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXD7"/>
    <dbReference type="GeneID" id="38783794"/>
    <dbReference type="InParanoid" id="A0A401GXD7"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="266"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="425" mass="47575" checksum="3A89E437DE31E86D" modified="2019-05-08" version="1">MSSVGTLWTIPQQPNGKRIRAVAAFAGLSLELPAHYTHFEDNKKPEFLSKFPLGKIPALEAADGFKLTETSAIARYVAGLAPNSTLLGSDLKEAALIDQWVSLTDSEIAAPGNIINRLVNGRIVPYNKPIHTAMLEHQLRALKVVEQHLATHTFLVTERITLADITLASVIQRCVELTFDAAVRAEHPSVIRHLETIVNQPKLKEIFGETTYVEKAVQYTPPAKEKKEPKPAAAPAPKAPKAEKKPKKEEEDDEDDDLVPKEEPKPKNPLDFLPKSTFNLEDWKRAYSNKDTRGAGGSLEWFYENFDPAGFSIWRVDFKYNNELTQTFMSSNLIGGFFNRLEASRKYLFGSMGVLGHTNDSIITGVVILRGPDVKPVVEVAPDWESYVYEPIDLKDEKQKAFFESALAWDLEVDGKKWVDGKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXI5</accession>
    <name>A0A401GXI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617840.1">
        <property type="nucleotide sequence ID" value="XM_027762039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXI5"/>
    <dbReference type="STRING" id="139825.A0A401GXI5"/>
    <dbReference type="GeneID" id="38783844"/>
    <dbReference type="InParanoid" id="A0A401GXI5"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="51302" checksum="2E590555CE401101" modified="2019-05-08" version="1">MPRPTISLDSLGYDTTVRFRLNNLGEFFTQPRGAAVISRETEPFGHGGWKIFFQSNTRADDDCLQVRIVPPKEGSPAVDYSVIGESSRGKLYFIVASGVSTAFHPRSKAAGGDDALSRVHDWSRDEHLRNENSLIVTVNIKTSAPCPMPAAQPGERGEMFSFLHRTMINESPINMRYIAFTRRISSGQLTCARAIFANELVLTEASAYMEDLHYTEQFTAIAHRLDEDLLVDDLKSTQTTYMDDDSDFEDDGETQAVTRPRDHVEGSYDERKPSITAEHNQIDADDTMLNDFDGGTVVVDGAAARTWEAFIFYLYSGKLEFAPLKSAGASIRKEFFKNHRERKPQLPTPCSCKSMYRLAKEIECESLRVYALGHLKCQLSAHTILTELFSEFTARYEEVYKMEMKTLRKLWKELEGTPALQEKLTEAVKYPHAGRIVADIFQMAMNAPGLRHKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXK2</accession>
    <name>A0A401GXK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617825.1">
        <property type="nucleotide sequence ID" value="XM_027762024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXK2"/>
    <dbReference type="GeneID" id="38783829"/>
    <dbReference type="InParanoid" id="A0A401GXK2"/>
    <dbReference type="OrthoDB" id="3265221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="188" mass="20764" checksum="4C8B34B67A6C2177" modified="2019-05-08" version="1">MAMIRALPVEEYGAFTSALLQHDILSKDVVTQAFVTEEINHRHRTTSSPKADQALTTASSSQLTCNFCESKGHTQSNCYAFQNASKKAKENHKERRFKRGNKANATAAAAATQNTTQVDPTTVTESAGKASLSDPLQLDADFDWNADTGATSHMTPHHHWLRNYKLNLPSLSSDSICCLYHRELHCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXP1</accession>
    <name>A0A401GXP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_1001730</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617842.1">
        <property type="nucleotide sequence ID" value="XM_027762041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXP1"/>
    <dbReference type="STRING" id="139825.A0A401GXP1"/>
    <dbReference type="GeneID" id="38783846"/>
    <dbReference type="InParanoid" id="A0A401GXP1"/>
    <dbReference type="OrthoDB" id="3227225at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="102"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="345"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE86929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115648" checksum="D1E3481ED5E73D34" modified="2019-05-08" version="1">MTFLHSRQTLFVASITENYTAFLDGTVQSAPESAQAITTVPLDLNLWHHRFAHHNYADVQKRIREELVTGLMLDSKQQPDPICEPCLAGKMHANPFPTSDSHASKPLELIHTDVHGPLPVCTHSGYRYWITFIDDYSRFRVVLLLKAKSEAFDAFKQYKAYAENLLEAKIKAVQDDKSGEYMSNAFIQFTQEAGIERRHTTCNRPQQNGVAERANRTMDNDITAMLAESKLPPSFWGECIASMVHVWNHLPTAVVKGATPYELWYKRKPDVSHLRVWGCTAYVHVQKDQRTGLGPHMQKCVFIGYPAGYKGWKFYNPDTKKTIISEHADFDERYFPGLKCTPDIPPPPPMSFSPADIIPLPVAPVPGQDLGGDGAHVPNPIPGPVASEADPPAPPAPPAPEHPVTPPPPDPSEHHRVPTPPPFEPIDHHPIAQCRVPRNIRPTWKMQTSPPPVQDAESEDELDVIDADADFVEVQFAGLSAGAGPRTYKQAMGSSDADKWQQAANEEIVSLMANNTWDIVPLPPGKRAIGSGWVFKVKHNADGSVEHYKGRLVAKGYSQRPGFDYTEVFAPTFRQPALHLILALAAAEDLELRSVDISSAFLNGDLEEEIYMQQPEGFHQGGPEMVCRLNKSLYGLKQGARQWNKKLHEVLTKMGFTHLQSDRSIYVYIRGDVRIIVPVFIDDMTLASKSKKALDDTVKESKSYFKLRDLGSTQFLLGIDIKRDRAKHTISLSQRQYIVDMLEHYGLSDCKSVSTPMDPGAELSKALAPQTQEEAEYMHKVPYLSAVGALMYLAITTCPDIMFAIGCLARFNANPGPAHWIAVKHVFRYLKGTMDLRLHYGPSDVKEFFLTYTDSDFGGERDNRRSTGGYLVKVGTGAISWSSKLQSLIAQSTTKAEYIAAVEAGKEILWMHNLLTELGYTVSKVSTLYMDNQSAISVSKNPEHHGRMKHLDLRFFWLRDTVEAGQIAPVYIPTAEMIADILTKPLPAAKIIYCREMMGLSVTKLLSEERADDFRLYLYRSRDNDVTEPRLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXV7</accession>
    <name>A0A401GXV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RCC1/BLIP-II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0905130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617547.1">
        <property type="nucleotide sequence ID" value="XM_027761746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXV7"/>
    <dbReference type="STRING" id="139825.A0A401GXV7"/>
    <dbReference type="GeneID" id="38783551"/>
    <dbReference type="InParanoid" id="A0A401GXV7"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028641">
        <property type="entry name" value="RCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46207:SF1">
        <property type="entry name" value="PROTEIN RCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="154"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="274"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="385"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="456"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="459"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE86634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="59378" checksum="6568C1C89FEF807D" modified="2019-05-08" version="1">MSEGPSDPNRESTNANYNSQHEIQWGRVLICGGTDWPKLGRKDRAGGSKKVQDDTSVPGPDLLEPHILRSLSNVKVVSIHTSCVGCHVVALDIDGVAWLFGRNERSALAVAGVDVISENEPLRLTPHELGAPKGTRFVYAGCGKNHTLLVGSDGQLWTAGANNMGQCGHPVCPEVASFKLVHWPKHLSVKEHVVAAAAGVTFSIVLTQGGRVYSFGSGEKGQLGNGKTGEHIVTAGKVAFDVEHEPILVKGLEDCKIVKIACGQQHSVALDSEGLVHVWGYNGYCRLGLGNQQDVLIPKIVPQFAGPSEMSMGADVIAGPSNTVVIDKQRMYWMAGKWKNTGDGSSGQPYSSFRYLQDIMGCKITYASCGGVTHWALAPDDDGSVMTIAFGQGAANGELGLGPNEPKSQTKPTRHQPLIGIDVFQIAAGQNTTFFLAGPNEKMSNLPRHPVDVDAPELCVLCNKDNGDDDAPLECDKCDHPYHLNCLDPPLDAIPDGEWFCPECEKALIGATEKGGAKRAGKFKGKAVEEEKATAKAGQKRKAPVNSKPSASKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY74</accession>
    <name>A0A401GY74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1004040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618070.1">
        <property type="nucleotide sequence ID" value="XM_027762269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY74"/>
    <dbReference type="STRING" id="139825.A0A401GY74"/>
    <dbReference type="GeneID" id="38784074"/>
    <dbReference type="InParanoid" id="A0A401GY74"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="9">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="766"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="626"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="799"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1061" mass="113745" checksum="8E66CF0450D50DB9" modified="2019-05-08" version="1">MATSSSRQNSRFSTLKVFKFPAVSKPPPLPPKDTYYQPNPSLPSLNHTLSPDSSSSHPSTPISPRYMGLVRSPSPSPSYAPSRVTMSPPSSSSSLSPDSAGSRRGLFKFASLVKRPKTPKSTESASADAPPPDPNGDPSISMPWNFQHNLHVDEGYFGLPPTWSASLANLGYSPEEIATINSRRAAARSPHTQSIYLLSRAGNSDSASATYSSVHHLPRATSPPRSDASASQPSLLINSASRTHSRNASGASRQYSEASSFEVIPPDVMARTPPQFTRRTMTPVQAPPPDTSSDSASARESTHTRNSAQRTPPRRAFHVANGSLDTQSSPPPAYNSVKKSTHLDGINEDTHPVASTSYPREKKAGHSEQRNFEEKDTLEASSSARSAAPPRLSLDKDTLSDLSSWTESLFSSIPSAVSEEPLSHTFQPIPTISISSNPISPPAPYSSAKSGAAARSFSLERTIPPQKPIPLHQLPSRTIAAPSTSNTPPSSANTTNPLWHEVMDMVRTPTEPALTPSSAPRSSPLTTSFATPVTPITPPKPRLLREHSTDNLHTDEMGAAREKDNRDSDLSTMTIGPATIVCAAVARSARANMVPSPVASPVVDESQSTLAASMGAEDAEDATAARSPTPNSSKSRSSGSSVSMTMSVSTVVSGSESSSSTSCRHVATPSEKDWAPGRLAKPDGAAFVPGEISITAVEDDDGVIGDKVTRRPSVAVATPPSPVWTPNAASVASPATPAPRYPGWVSEVVAPLQDFIDEASDPRELYTDLQEIGEGSSGSVYAARVLASSPGEPPYVAIKNIPLLPSGVPKLEDLQRELTLMKGVRHPHILSMDAGYVDVVEDSLWLRMDLMERSLADVVVLVAEGIVVQEKPIAQFASDVLSALSFLQSLGIAHRDLRSDNLLVGRDGVVKIADFSSAVQVSRDQPMRTDLAGVIYWQPPEIRRGSYNALKVDVWSLGATVWEMAEAEPPFFGIEDPRQLADRWPPLRQPEIYSRSFHDFLHQCSQPNSLRPDPDTLSKMPFIRNANGRPAVIKLLSECRAVEERIARRQSTDSDGTVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ53</accession>
    <name>A0A401GZ53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SCP_1101190</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618356.1">
        <property type="nucleotide sequence ID" value="XM_027762555.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GZ53">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZ53"/>
    <dbReference type="GeneID" id="38784360"/>
    <dbReference type="InParanoid" id="A0A401GZ53"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1508"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1543"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1576"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1621"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1664"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="20">
        <location>
            <begin position="884"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="860"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="875"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GBE87443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1803" mass="200369" checksum="E85CD001A5BB7F1E" modified="2019-05-08" version="1">MGDECLRRVVARLQNLPSISLPTDYPRPTGGSRLVEAAITADLSEQTCLGLLKLALYNEDEDGDGDGDDEKGHKTPSAFHLLLAAFSVLLHRYTGDTDLVIGSSAASARDPLVLRLEVNPSDPFWQVVRKVQQVEKDAEVDALPFESIVRALGKGKTDSVESSRPLFRVRFFDETDTPQENFLRTTSLTSDLTVFITRQHENSRTSLTPHISLRILYNSLLFTPTRITYIVDQLSVLLRKVAANPLAPVGSAPLLTSAQRAKLPNPIADLNWCGWKGAIPDVFSRNARQWPDRPCVIQCLYPASSNESQEKRTYTYSMVLHASNTLAHHLLEGGVQREDVVMVYAYRSVELVVAVMAVLKAGATFSVIDPAYPSSRQKIYLEVAQPRALVVLKGAGTISPPVREFITNELKICVEVPALELLTDGTITGGSRSDGGDVLKGQAHLAETDPDVPLGPDSVGTLSFTSGSTGIPKGVRGRHFSLTHFFPWMGERFELNKDSKFTMLSGIAHDPIQRDMFTPLFFGASLYVPTAEDIGTPGRLAEWMADNAVTVTHLTPAMGQLLSAQATHQIPSLRNAFLVGDVLTKRDCLRLQSLAANVRIINMYGTTETQRAVSYFLIPSVAEDATFLTTQKDIMPAGEGMIDVQLLVVNRNDKNIPCAVGEIGEIYVRSGGLAEGYSDPSATAEKFVKNWFSENAPPWKDTIREPANGQSGPEARFWKGVRDRMYRSGDLGRYLPNGIVECTGRADDQVKIRGFRIELGEIDTHLSQHPLVRENVTLVRRDKDEEKVLVSYFVPVSGPLLDDFASDIPEGEDEKGLITGMHRYRRLIKNIREYLKKKLPSYSVPTLFVPLKRMPLNPNGKIDKPALPFPDTAQAAATESQRGPTATPTEEAVRAIWTRILPNPPSPIPLDENFFDVGGHSILATRLIFEIRKAFLVDAPLGLVFDRPTIGGLAAAVDDIRNADLGFTTGKTPGTLTPATHAAVGTVKTIAYGQDYDNLLSKLRPSYSPLPADFGGKRLTVFLTGATGFLGAFILRDLLLREDRVKKVICLVRAPDLQKALDRLRDAADGRGVWDEEWLKTSRVEVVKGDLDQEFFGIEKATWDRIADEADAVIHNGALVHWVYPYEKLRYANVLGTLIAVDLAATGKPKAFVFVSSTSDIDTEYYVQLSESSHDQSSLGGVPESDDLEGARTSLKTGYGQSKWVSEKLLFEAGRRGLRGHIVRPGYVVGDSRTAVTNTDDFIWRLVKGCIQLGLVPDINNTVNMVPVDHVARCTVLAVLAPLPAPRDALSVLHIAAHPQPTFNDMFSALARYGFATKRCEYLLWRSQLEKHVMEVQDNALFPLLHFVLDDLPTSTKAPELNDENMRALLAPHMQLTNRTVDKELMGKFAMACERLRGKSGRPQWTVDAENSMLLIVHMTEDKGDRVDIGLPDSANPQFYIPRFRLDMMVDVVPTIRSVYDSDPDWLTDASSSYLRIAAISIAAYDYLLTLPAELRFYKVQRSWMPSLGCILFILIRYVSMITVTVSAIGFFASFSPQSCQRWFMVTPVFKVLQMVLSQIIMGIRTVNISRRKPWVVWTMLVVFLVVTCLEFFTNLYDRNYVQDRHNNCTGGDNSAHLSVWLFYVVAMFYDVVTIGISTYFLVSFSPSSGRLSRLVRLMLYDDIGYLVLLTAANVLNLVLYRTSDGTTQSSGACLSFAVVWIMSQRILIHLREHTRTTTQVISRPLQSPRDISDAMRSQFETKDQLDEEFGLPHPRAASSVQLDSVREGCELDVQVHVEETVTVEYAEDTSERESYRTPRPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZR5</accession>
    <name>A0A401GZR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1103060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618542.1">
        <property type="nucleotide sequence ID" value="XM_027762741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZR5"/>
    <dbReference type="STRING" id="139825.A0A401GZR5"/>
    <dbReference type="GeneID" id="38784546"/>
    <dbReference type="InParanoid" id="A0A401GZR5"/>
    <dbReference type="OrthoDB" id="2161780at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049373">
        <property type="entry name" value="TyrDC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF4">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE-DEPENDENT DECARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21391">
        <property type="entry name" value="tyr_de_CO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="L-tyrosine decarboxylase C-terminal" evidence="5">
        <location>
            <begin position="595"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="990" mass="110434" checksum="708CF66388630694" modified="2019-05-08" version="1">MASRIYEPSPQSEMHAAVSSCFLGPQAENFDLLKDLFIKVVEDQANARRAYHPEDGIFITTEIKESAAYQNKVADLRKQFSILSDLLNTFSVPFYSPRYAAHMTFDTSMPAILGWLLAGLFNPNNITFEASPMTTLLEIDVGNQLCEMLGYKTRAIAKTGEAIGWGHIACDGTVANLESMWAARNLKFYALSLREAMEPGGPLAFIADRFKVGTCARPNELVLLTELSVWELLNLRIKDILDIPERLSNEFGITSQFLEDALGDYLIQSTAKDVLEVKYGIQSPQYLVSSTKHYSWPKSGAIAGIGSANVVDVPVDTNARVDLECLKAALEERYQNQQAVYAVVAIIGSTEEGAVDPLDAIVKLRDMYEARGMSFVVHADAAWGGYFASMIRDKPVYHVPTAPRRDDREFVPSVTLRPSTVAQFHSLRHADSITIDPHKSGYVPYPAGGLCYRDGRMRFLLTWTAPYLPQGTAESIGLYGVEGSKPGAAAAAVYLHNTVVGLHKEGHGGLLGEVSFTCRRLSAHWAAMSDDKTDFVVVPLNPLPDESTSDAVAKEKEFIRSHILGKSNEEIWNDKEAMKVLCQLGSDLNINAFACNFRINGKVNEDVEEANYLNKRIFERLSITTTDKTPQDVPIFISSSVFEMKNYGKCATRFKERLGLETRSEQDLFILRNVVMSPFQTAGDFVQKLADIFQGVLEDEVKNVVHRNTISPQRHAFIMQGTNNIYLVYRSLFHKANSRFQLIVSANIEDAAQLAQYQAARKANPTENYWLQTQREVPLSDILKNGTFTGTIRGKGLDLSEVVVSSIYVVKERPLDSMWRDQNYPADSIPFYLYGSLQEQHVDHMLLQAPNAQLCADRVALSLAEVDRLTDENLRKGVLLFIEGLHEQAMQPFSKDDPPNFFKAGTKFNVKVYNDPRAATTHGPGLAKVSPRDFIASGTLTLGTGIFVDYTDLNREDFIEGKQHTTNYTSNKISPAIRQEWQDVMRSYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZT2</accession>
    <name>A0A401GZT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1103500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618586.1">
        <property type="nucleotide sequence ID" value="XM_027762785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZT2"/>
    <dbReference type="GeneID" id="38784590"/>
    <dbReference type="InParanoid" id="A0A401GZT2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="13012" checksum="FB8A3BE317A2AD38" modified="2019-05-08" version="1">MCQIGHLTWREMVHSHSSWCCSGQSPPAACGSSDDPRACPACDLGTLQAPEDLPVISARDAQGFKFALWLEEEMRKLVYLCATARPKDQSDEDLGAFIVHGARTTYQFSSTCRMAPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H072</accession>
    <name>A0A401H072_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1200360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618724.1">
        <property type="nucleotide sequence ID" value="XM_027762923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H072"/>
    <dbReference type="STRING" id="139825.A0A401H072"/>
    <dbReference type="GeneID" id="38784728"/>
    <dbReference type="InParanoid" id="A0A401H072"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="553" mass="59423" checksum="8B636CADCD4AB48B" modified="2019-05-08" version="1">MDRIHEFYQSYSWHQSHDQATVLLLVPYETVEEEVTVAIERNHLVAGVRGQAPIVKGRLYGTVDTANSDWQLEPRASPRSTRERATSTTSAGSNQSSYAYVSDPDFSSSFAASLENGLASELDDPVSSSPALSSPISSMDENSFAMLNHRRSHGASRPISPPSAPPFSLTSSYSSMESLHTASGRLLTIHIEKAESMIWPSLVVGPVPETLSPSMLGAYPWASASTLTAESKYNMDPTSLVLLALDLYDIRKAYEEAFEYFVRAWHQAHVPSATIRLATHYLPLQSVFPDLVPSPSSHAPPLESVELTEVPAISPSTVEPSTPKQVPPSMPPTPGTPAYYLDRLGGGPGLAQLFLAAGLLHLEGAAAPLLSSAYAGLSSLRAPAHTSSSISGAAISASHHTHGSSTDAWRRDRAAARCYFERARALAPALDVPLLPPDADSDSSGKESGSGDRDRERGRRGTILGPGARQQLEMPSIEVHRAPPTPAEQQTRRRRKKGSGDLSSAIMEGVRDADADDDDRTWYLYIPGLVGAGTALLVVGFLSFSSWRKSQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0C2</accession>
    <name>A0A401H0C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1200860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618774.1">
        <property type="nucleotide sequence ID" value="XM_027762973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0C2"/>
    <dbReference type="STRING" id="139825.A0A401H0C2"/>
    <dbReference type="GeneID" id="38784778"/>
    <dbReference type="InParanoid" id="A0A401H0C2"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="492" mass="53661" checksum="9D6DA3CCA4CEF02D" modified="2019-05-08" version="1">MPTAVTTTATSTPQTLSLKASSSSTSADSTLATLRSLYPRAARAFLQRNVALTHSLLLSAFAIIYPPVSPAPDAISTQRRKWDILRVTFETTLYASPPPTHDLDSFPQSLRANLMLSPESFLATVHTRSLQLFTPSTPFQKPSSAFLPAQILVTLALASLKLECTHVGRGMIEDWLARHIPAQDSDKSEGYAKVLELYCLHVLPRLEEWDYAEDFLQYERQLPAETRKYMLTSLQNLRAQTLTMRASTPLPSASPKLSYPSRSPSPALSNASSTSSSSTSTHTATPRTPRPGRLAGLTPTSTLTNSTSTQSISSTTTSRTITPTSARRPRSRSRTETKRQDPIEHVWGAASPPARSVLQPERSTPPGMPAHPVARRPHSRAHLDATAERELAQRATGQQSIVALARAWLAALLAPPRTKLTAFVVFCIALPVLSFFFRRRRAKTPVVGHVAAAEGVRRRLRAAEGKGVLGTLWEELVRAVGDTVRMGGRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0J8</accession>
    <name>A0A401H0J8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1201700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618857.1">
        <property type="nucleotide sequence ID" value="XM_027763056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0J8"/>
    <dbReference type="GeneID" id="38784861"/>
    <dbReference type="InParanoid" id="A0A401H0J8"/>
    <dbReference type="OrthoDB" id="2855870at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="476" mass="53230" checksum="E1DFF79202FE53B5" modified="2019-05-08" version="1">MKSPTKPITDIPMRDVETTEAATRATSPSPRSRTPDVFDDETTADHDMGLNDHLLPIKTAARWPTMEDLEKSMQRAAKMLANFSIHANYTPSVIESANTISDKLTQITDIDKSPRKTPQTQQNSQNANQPRQPGNEFMEQIANSLTLLTSRLDTIEVKIASPQGTATRTQTPVTGTPTSEKPSNTSPVTEAGPRTVHATSKPIVPKPKGTMNNNTKVGSKGIPTNPLAAHHPSRLIVEIQKGAPGGERPKEIDLVRQINDVLQSSEDSKHLRVVNVKFNPQQNCIVFTRADQSAAELAPFADRFTEYIAQDRPTRVRPDVPWYKVQLNGVNTFNDYTNDIPTPEELHEELCLNNPTYATMPILQLPRWMHHPSDLKTQFFSSVVIALMNEADAEHLVKHVKNLAIAGRFAEVKRYADKPPIIQCNNCWSLDHTRWRCHKKPICRLCAGDHLEARHVCDQCPMQDEEEDAMNTEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0W5</accession>
    <name>A0A401H0W5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1202940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618978.1">
        <property type="nucleotide sequence ID" value="XM_027763177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0W5"/>
    <dbReference type="STRING" id="139825.A0A401H0W5"/>
    <dbReference type="GeneID" id="38784982"/>
    <dbReference type="InParanoid" id="A0A401H0W5"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="108"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE88065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="301" mass="34372" checksum="89C3320BB14C8C73" modified="2019-05-08" version="1">MGDKFTGAAGPVFVFLAVVLLTLGALCFFVVVQPTLAWPWLSTPVCVLLAVNTFTHYYYVCTIPPGFVNDSPHPPRSGLLWAKKREPSRRAGVRWTETTITKASVTRCGRCGEMRPERSHHCRICNRCVLKYDHHCPCTTTDTVYMVIASFCLAALGWRHVLSALGWYDEYWPYLIPPTIFLLLYILATVMCFAVCIMAAWHIWSISCGETSVESQDHEQYRKMARGRGEAFVNSYDLGRRKNLELFFNVGQDGYPLYTLILPLRVEPYTDGYSWARKAGYERHRGIRQGEELTDEDDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1M8</accession>
    <name>A0A401H1M8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619237.1">
        <property type="nucleotide sequence ID" value="XM_027763436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1M8"/>
    <dbReference type="STRING" id="139825.A0A401H1M8"/>
    <dbReference type="GeneID" id="38785241"/>
    <dbReference type="InParanoid" id="A0A401H1M8"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="234" mass="26753" checksum="9BC71F7822A63651" modified="2019-05-08" version="1">MYPTPEDEAVIRAADELMIKTMARYDPSHDAYHVQRVRKTALHLARALSLSEVGRKPDLLTVELSALLHDVLDKKYVSAAEAADPYAFFRPFFDFVASTHGVDLVKDGRAREIAKIVDNVSWSTEKKLREAGLLGEWHRDCIELHCVQDADRLDAIGAFGILRCAAYSTVMNRPLHIPHDDSAYSSCAIEHFHEKLLHIRERLKTEPGKELAEKRHQLMLDFLQAVDEEYYVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H232</accession>
    <name>A0A401H232_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1303130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619410.1">
        <property type="nucleotide sequence ID" value="XM_027763609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H232"/>
    <dbReference type="GeneID" id="38785414"/>
    <dbReference type="InParanoid" id="A0A401H232"/>
    <dbReference type="OrthoDB" id="2803586at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="34287" checksum="4DB9B07B9E0E7FFA" modified="2019-05-08" version="1">MLPTLQITGLMRAQKIFSISTGINVNSLSISSDTEFYLFMDMRAEKKWASFNMTPCKWVEAAEAYNSRLEALNSAKGLPTVWKTPRALMDKLGELEPKILICIASKDYTSKRSNSEMFWMKHYLAVTLLKTPEQGDGKWRKTHTCTRCKRIMWPAQEGSRENHRKSYCTDGVRQTARKVQRLVDGKTESIMEEPPNFPQPQGIFMTGTHFHPVIFLKTIEDMYEQLVVQGGNGGALSMEFTAFTTLLEKRLKIHSDGMALFELYSSLEVASTSSVAKAIVECNEVKYLHVDCLCDEPETRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2A0</accession>
    <name>A0A401H2A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1303930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619489.1">
        <property type="nucleotide sequence ID" value="XM_027763688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2A0"/>
    <dbReference type="STRING" id="139825.A0A401H2A0"/>
    <dbReference type="GeneID" id="38785493"/>
    <dbReference type="InParanoid" id="A0A401H2A0"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="2">
        <location>
            <begin position="344"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="553" mass="59680" checksum="309FDB6F3F1F0868" modified="2019-05-08" version="1">MPLPSLSISDLKGKALQAKDYSTARISRLSSPATKNLSWDTSKPPPPPPPLKKPEKIVHANAQPPPPAHPSSRPSSLDITRPTVTVHARTPSNLKESTPAPSPARAVPVRPPPVSRRETRPDSATSPSLSRSQSIQSDRQREVDRIDWTNLSAEDKQVFFSWLDEFFERYLNRPILAKNPQDAVENEEDPPSVQSISASAARAPARPAPPSASPANTRPPAISMSTRPKQPSPQPSAYDGSSDALTSYPAPTLTGCAALDLAQYFTPSTHWDSSWYTNTSPMPPPLQGNGEIAFTAAWEMHGSSKTLYAGVIFADLSMCWFSVQFSTSTQSDPNDSRGVRRGAQYLPCPAAMDHAALVEAHETYGETVAGFAESFEGTGEFCGRGECWDLADGALKYFDQFDYVPKPVPSISRTHGHLMFEGKVADKGRVQVGRWRGGDDRVRRGDIVEWRSARLAMGRGGSAILGNPDHTAVIVSDAVPTCAVGDGMSVTPSGLGTLEVVEQSVGNPPARALYNLGGLEEGEIWIYRPVGMLEYVGTLLEAKCPETVSARSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2C9</accession>
    <name>A0A401H2C9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1303590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619456.1">
        <property type="nucleotide sequence ID" value="XM_027763655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2C9"/>
    <dbReference type="FunCoup" id="A0A401H2C9">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2C9"/>
    <dbReference type="GeneID" id="38785460"/>
    <dbReference type="InParanoid" id="A0A401H2C9"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="16083" checksum="A66A8E86E16F3E1E" modified="2019-05-08" version="1">MHSTLVRLAESISKRPLNLQKTSAILLPPLPLYRRILRAHRSLPYEMRSLGDDYVRAEFRRHQEIENKVHVIGFLSQWKQYLDELPVGPEAKHFTGKKLDPTVLEKMSAEQLGQLYELMHATKDVWKPVGEDTEVGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2R1</accession>
    <name>A0A401H2R1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619649.1">
        <property type="nucleotide sequence ID" value="XM_027763848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2R1"/>
    <dbReference type="GeneID" id="38785653"/>
    <dbReference type="InParanoid" id="A0A401H2R1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="510" mass="55252" checksum="E3B12DB4968242C1" modified="2019-05-08" version="1">MSTTRKITAVVKVHFNEHGLDDRMVPGFRWSQMVPISATVMTIELYIPYWSMADLRAGRDTGFEKGVGLSLRPLQRLERRFSGVLISEMVVHRRDGRVRPPIMIANDLMPDAAKYGSPAFKYEKCPMEWATVVETFVHGVVIKIAAGEDDFRTGSSSASTTPSSTNGRHALEDKESGESEAAPPRPAPWNDTPKVPSSAPTANAPSKSRKRARDDEPSTETEAALPHKKARTRIAMVPTSRENRRSERTTSRKSNERTRAGAARIAGRLTTKATEVATTRATATTNVHTMTVPVVPPMPLPFMAPQPIYYGPASAAVTPMPPQFVAPQPVHHRYPITSMSAIGAGPSRWFPNQVAPAQQFRPVRPAASLAGMPSVAVDWEPRRPTTYAHTTWTMPPSPTGFSQLPNIARSLRSRDMRESAAPPPPPTDAAYEWMPAPPQTHEALPSGLHAHASAIVPAPLVLPGSPIVLPQEFDVNEFGGGEFGPFTDAYLSALGVGMTGTSNPTTGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H382</accession>
    <name>A0A401H382_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1403040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619809.1">
        <property type="nucleotide sequence ID" value="XM_027764008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H382"/>
    <dbReference type="STRING" id="139825.A0A401H382"/>
    <dbReference type="GeneID" id="38785813"/>
    <dbReference type="InParanoid" id="A0A401H382"/>
    <dbReference type="OrthoDB" id="2418900at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="403" mass="45686" checksum="DD2FB8D5951733E9" modified="2019-05-08" version="1">MTKHSDLRYFKDGISVISQWTGTEYKNMEKVFLGVIAGAAPQPNVTCAVRAILDFIYYAHFELHSEESLKKLEHSWLEFHRYKQVFVNEGIRDDFNIPKVHSSEHYPYSIRYLGTADGYSTEGPERLHIDFAKVAYAASNRKVNYVKQMTVWLERQEAVYRFDSYLAWIMKNNPDADEKDDEEDIDVDDLIDAETLRTENQPQQSTQPLKEGQFARGYAIAKEPAYPRMTVASLMHDLHAPDFVKCLEEFLQKTGSGGSILLPIHNKTRVPVYSQMKVQLPVAQQITSEVVVDTIHASTPRPTKGTRTEVPAQQSTVLVKDSSAQSASGGPLHGLHVAQVRAIFKLPDVLAVEHSDAATVLLAYIEWFTPFHVVDADTGMHVVTWSTRQRRQFASIVWVTDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Q3</accession>
    <name>A0A401H3Q3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1500350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619946.1">
        <property type="nucleotide sequence ID" value="XM_027764145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Q3"/>
    <dbReference type="STRING" id="139825.A0A401H3Q3"/>
    <dbReference type="GeneID" id="38785950"/>
    <dbReference type="InParanoid" id="A0A401H3Q3"/>
    <dbReference type="OrthoDB" id="2782214at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="353" mass="39200" checksum="E4A15D344CD02F17" modified="2019-05-08" version="1">MQHDATRSNSNNYTSELASALLEMNIGEHAETGMRQRANRPTTSRDIETRRAGRSRWSDLPEYHVYPSSMSTSMNTAFPDAHLLSARSGRGSIAEPSSRRSSSAHRSSSAHRSSSAHRSPSAHRSSSTQRNASFRRNPSTDPIASTGRAIHPQFEPYPVYNVFSLPTRHLSSRPPRTAYYPNMQPMNPTPQVYAPPLSNGPSYPSFRQTGPGGAGGYYAPPHYCPPAPIAQPHPLPQRQDPIQPDFSIPTRVRCRWGDDWCPIELDDTSPGGIDRHLRDYHLGVQPDKRASGKCLWAENDVQCGRPMAYGSLGKHIASMHLHSTEQECPNCGNTYARQDVLTKHLRRACKGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3U1</accession>
    <name>A0A401H3U1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1500870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619997.1">
        <property type="nucleotide sequence ID" value="XM_027764196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3U1"/>
    <dbReference type="STRING" id="139825.A0A401H3U1"/>
    <dbReference type="GeneID" id="38786001"/>
    <dbReference type="InParanoid" id="A0A401H3U1"/>
    <dbReference type="OrthoDB" id="2749714at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="70062" checksum="5D071DCE640737F2" modified="2019-05-08" version="1">MRTVRCFWYDNEGKPYLHRGTTTVRGCTRLNCTFKHPDQPGWEQALTSRDKPAPHLLADEEMDKVYGPPIVPVHHRPRSPYVPRNRGGHSPARSRSPGRSPRRRPKSRSVSPRRRSRSKERQRRNDSVSFSENSSPFRTRPHRLSPGRLTERRSPIHDSRKGSLPKSNTSDNVAIKLSESPVLAAARVGDAPMKKGTLKIVMPAATAPEVVPVEVVPRSITNSVKAEAQPDPVLTAEDKRKTWATRIEILSTATTVRAEREKLDRDLRDLSRLVGSSHFTSLPEEEQTRVQAHVSDLETRRAAREAELKRTVSALAEVDDLPALATEQPPSNTELVTQIEELRSSVAQLSELLQTVSARVHAGGVRAEQGSSTPAKRRKLSTDGSGSDAPTLVEAAELNEMRQRMDSLEQSLAGVENNVNTLYGDMSQEVTALREEMAQNAAARRRSPSLSEGAAQRLESLEKEVTTTGEEIAELAQEVGGLIRDRGTMLIESERLKLENHELKKQIEELQGSYKTSLETMRKEISVLNAAVILRLAQPPPATITTCPWDVDQILDAVRPSLTAFVRTEVQPLLDGLRNSVQELLAVHDAQFCGMMASKLAVTLQAAEAMRTWLDRVGMGALGTPANANGLGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4W4</accession>
    <name>A0A401H4W4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620332.1">
        <property type="nucleotide sequence ID" value="XM_027764531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4W4"/>
    <dbReference type="GeneID" id="38786336"/>
    <dbReference type="InParanoid" id="A0A401H4W4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="7995" checksum="6789015A4CA7AEE1" modified="2019-05-08" version="1">MMGAVENECKLPAKTPYSGARYVAYWCSPIVIERLQVPTSDGHDTLGYQVLARPSTSMASLLKGYSSGRNLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5D1</accession>
    <name>A0A401H5D1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1602640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620514.1">
        <property type="nucleotide sequence ID" value="XM_027764713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5D1"/>
    <dbReference type="GeneID" id="38786518"/>
    <dbReference type="InParanoid" id="A0A401H5D1"/>
    <dbReference type="OrthoDB" id="3256662at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="539" mass="62351" checksum="F533A836D6838CBD" modified="2019-05-08" version="1">MTKFACTIPERRSRRGRLTTLSCDVYNLIVDEFQYQPEETSIWVYKSTLASWALVCRFFHHLATPKLFEVFTFEKEQGDKDDPQLEQWIMELNRGNDVAHALAPKVKHLTFMNWKEEYMAQKFKFSQRRLASLTSALRYFTNTVNITLLNSPIDVRLFTAIATLPNLQTLCIRNCEFQELRKPVVLPADGIPGLKALEVLEVDYAEEYIPAIISMAATPSLRSLVTTEWKIAKGIMKQDVNIPLEKLEVPLQPRGVAIVSTFLDRTPSIHDLSLVDILQDNRTPEGHEEIRRITLKLKQSSLPRLKKLKCPTHLFPSLWRSRPISTLSLMEPRDWIPLSTRMRKEEGQPPSYPFEDLARDSTLHELEIPLELYALYPLAEFFPPLDRLSICFPVHVSPKNPNGFQIVCGLRKPKMTVRYLQLYFFGLYEAGYAFDLVQQHSIIVTYLAKEFPTATCISMVESLEWHRSEHGDKWTPIMRQCEYFRRLLVVCQELWKSNMSAVRDFDGLLTETFQDDPEANAMLQAMLGKDCLPVTLFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5D4</accession>
    <name>A0A401H5D4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1603090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620558.1">
        <property type="nucleotide sequence ID" value="XM_027764757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5D4"/>
    <dbReference type="GeneID" id="38786562"/>
    <dbReference type="InParanoid" id="A0A401H5D4"/>
    <dbReference type="OrthoDB" id="2593559at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="2">
        <location>
            <begin position="186"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="364" mass="39442" checksum="1BB7557715585AC8" modified="2019-05-08" version="1">MIIPNEKLAPYPSEDKKASEITDAQMKQNDGAGQPPPYEIHRDIQVARAIAPQPTMSAPHAFGGPVPAQTLTPRATGATASPSSPTPTVVVPALTQLYHPTSAQRVNHFSVFSRHNSVSGTYLVDPSLPASPQTTTLSGLSMRRIERCNRSADREHAKNTRRAFGSDSESDCSSSRGWKARTPEVNAAFRTRHGQISVDVAVVGPNLYSATDALGMVKNQRARVMFSSRHGNISVNLREVQPGHCVDLDVSTRHGNMVILLPPTFDGAIVVHTRGDRDQVRFLQAFAECARTVRAHDRSTQIVLSPNANTTGREGDDRCLVSTRHGKITFGLSGYDKADGVLLGGGLFKMLGDLMQMGKSWRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6D5</accession>
    <name>A0A401H6D5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE89982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620895.1">
        <property type="nucleotide sequence ID" value="XM_027765094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6D5"/>
    <dbReference type="STRING" id="139825.A0A401H6D5"/>
    <dbReference type="GeneID" id="38786899"/>
    <dbReference type="InParanoid" id="A0A401H6D5"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="142"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="317" mass="35376" checksum="3A536DD5ABDA5CBB" modified="2019-05-08" version="1">MMDGVEPSRNVFLYDPRGYIVSGFWQYGIVEWKTFYNWLHTIVVSIEAWAIFARDDSAASPGPQGGPIAADDTIVAPGTYVLLSSDANPVEVGLTVQTPRLRHPTIPNTAAITEHYRRRVRERDPCCLISRLRVSAGDYSRHKEAHIFPCAHIDDWIKQGFPGYITDPAPPSQVGGPTKIDSIQNIILLRGDLHDAWDNYMFGVNPDAGYIVIPFVSGYDDIAGKVLKLDHIVDPDLRPLDELFRDHFLQGILKHMKGAGEPTWDYEDALGGGVMDLSRQDIWGGEQGKARLEFEFSHRLHSLLVKQEAGITEGQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6Q4</accession>
    <name>A0A401H6Q4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620984.1">
        <property type="nucleotide sequence ID" value="XM_027765183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6Q4"/>
    <dbReference type="STRING" id="139825.A0A401H6Q4"/>
    <dbReference type="GeneID" id="38786988"/>
    <dbReference type="InParanoid" id="A0A401H6Q4"/>
    <dbReference type="OrthoDB" id="3267098at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="82" mass="9254" checksum="13016378D39CFD4E" modified="2019-05-08" version="1">MAARADEAPVFPRSGGTAHKPKAFNLDTYKAHALGDYPATIRWLGTTDSYSTEPGELEHRTSKARYARTSRKQYIRQITQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6S4</accession>
    <name>A0A401H6S4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1801050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620996.1">
        <property type="nucleotide sequence ID" value="XM_027765195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6S4"/>
    <dbReference type="STRING" id="139825.A0A401H6S4"/>
    <dbReference type="GeneID" id="38787000"/>
    <dbReference type="InParanoid" id="A0A401H6S4"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE90083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="337" mass="35301" checksum="73E5937066C4D843" modified="2019-05-08" version="1">MQAESSTSTMSTAQSGADRGSGVLAGSEDAPEELQRKDIHNVHRDLGKRPRTEEQITETSGDSFANVEGPSRKRQRTVVAEGSSETAVHPEFLPSPPLELNLHMEEQDKRSEIDEDDEDADGDESLVESELQGFLLPGSGSQESLISTSTIRGVPIEARVEPEAASGDSSAAGSSCSQSPAPASHAEPIKQGEVIDVDAMPSTSYASSSSSDPIASTSAQLPQPVASSSRLSAFPSFSSVVTAPPQTEVPTIEPLSEYTCPICFSPPTYATLTPCGHVCCGECLFAAVKTTMQRATYSGVLGERTTARCPVCRAAIPGWDGKGGGVIGLKPRAVFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6S9</accession>
    <name>A0A401H6S9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1801130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621002.1">
        <property type="nucleotide sequence ID" value="XM_027765201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6S9"/>
    <dbReference type="STRING" id="139825.A0A401H6S9"/>
    <dbReference type="GeneID" id="38787006"/>
    <dbReference type="InParanoid" id="A0A401H6S9"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE90089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="234" mass="26397" checksum="BB72D51610130EC6" modified="2019-05-08" version="1">MSLKSQMSKCSTCYISATEKPLQKCARCKAAKYCSKECQKADWKNHKVNCMNNATLAEALKEHDSTPLGQLARLSIPDNISMYELDQRLEGWVKFHNPTLMGSALHALELSRDIMRTRSHVMYVKLAARPRSEHGNAVGKFFRVIDAYPVAVAEARQWPEPWPASLNALKEMQELHASNGRPGNTAAAMVECYPLAVQTVPFGSIPNMDDLPPLPNWKDVLIEEVDAGRRFRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5L8</accession>
    <name>A0A401G5L8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="4">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0103350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608373.1">
        <property type="nucleotide sequence ID" value="XM_027752572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5L8"/>
    <dbReference type="FunCoup" id="A0A401G5L8">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5L8"/>
    <dbReference type="GeneID" id="38774377"/>
    <dbReference type="InParanoid" id="A0A401G5L8"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF7">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="13">
        <location>
            <begin position="54"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE77460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="314" mass="34499" checksum="A73D1AAF300D6EA4" modified="2019-05-08" version="1">MSPSGDLQETIPVVPGFLLETFSLSSDADDLVSVYIGDDETHRRTLVSPDPTKPYVTLTFAQSLDAKIAGAGGKQLALSGNESMVMTHWMRTMHDAILVGIGTALNDDPQLNTRHLPPLPLHYPYRYYLPRPMILDSNLRLSPDCKLLKNYREGRGRRPWVICSNSIDPSGGDRDAFATRLARRQALEEAGARVLEVRTDHGMISIPELLRTLRGLGIRSLMVEGGASVIKSFLAANKHPAGPDRPAAVAERTFLDMVIITIAPTLVGRDGISYGSDLLAEELPVLRHLNTELFGRDAVVALRAVLERSDRTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6A8</accession>
    <name>A0A401G6A8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0105830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608614.1">
        <property type="nucleotide sequence ID" value="XM_027752813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6A8"/>
    <dbReference type="STRING" id="139825.A0A401G6A8"/>
    <dbReference type="GeneID" id="38774618"/>
    <dbReference type="InParanoid" id="A0A401G6A8"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="364"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="739"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="901"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="804"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="918"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="951"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="970"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1026"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE77701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1098" mass="120370" checksum="B3992CDF17E3632D" modified="2019-05-08" version="1">MATPFAFVSLLTSDSYLPGALAVAAALKDLHPVPPVQPEVEFQTVCLVTPETVDVSSIKLLRRAFDVVVGVELIEQEDNVKGLQLLGRPDLTHVLTKLHAFRLTQYSKLIFLDADVLPIRPISHLFTIPHEFAAVPDVGWPDIFNSGVLVFSPGEDKFNELMGLLRTKGSWDGGDQGLLNEWRGGDWHRLSFTYNTTPSAAYTYAPAYERFGSKISAIHFIGSSKPWSSIPYRAPGSVGAEKPPLGASEQQRNAYDYASLIDRWYDVYDRHYRTDQPMAHADFEVRRYTSAWDTEQEFGELPTMTGPIAPVAGATLGLEDLRKIAVEGMSRIGSTAEVSEQGPHEGEYRSLPLEGRVDLMRPRHEPEPQQEQHETQEQMEQGGDITPKQEEYKPSSGGPDQGQRTEQPPHHLYPPQLQRPLPAEQPYRQPEWHVGEQQYRPAHVPGHAEHHVHVHPRVDDYRRDESHSRSPPPEGITHHGHHRPARHYHGQPEHAPTSPPGPLPSLPPSQPPAPSQPQAFHQPEPRPPPTQTQPQPYQRPEPPRPPSPSKFSWNPAIEPPPNTAPGPSSFPVDTYFPNVWDQIPSQQHDATHQLFPPPPQSPAGPGLHTFFNPPPPAVIPEQLVQQGQYAGVIGQTHETPPTPDRSKVHAVFPWEEKPRHVPRRVFPVTDSPPPSTQYIEAELSPPTAHLGSPAPGRPILHVQTPPSAGLPSNLSYSNAWDTVPSIQRYASRLVRPPYRGIVASPSAPSDDGWRKWEKERERVVQAKQDASSMDGDDEDEGDDEESDKELTGRREQDGGRERSGSGSRSRAPSSASALSISKGKKYRTCGVQTTAVETRNQSVQVSILTDDMVPKKAIEVKPRGGGVSGVARREVAYSSIGTGGGLLPAATFREFKADPDQMGAATPLATHALRSTMPFPTTGSPSGLRSPQTLGSPRNYSPPKLETPPKVLSPPKSPSPPKVPSPPKVVSPRRLSSAQPVVSSPRKSSVSSKTSSPIVGPVTPPQSTPSPKLARLASPFAPLLARTSSNDTTITSSPSTQGPVITPESTPIMGSVRKGGRVWDPARGVDVFKRGSEEVLARFLRMGSFDEEERRVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6F0</accession>
    <name>A0A401G6F0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0106200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608651.1">
        <property type="nucleotide sequence ID" value="XM_027752850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6F0"/>
    <dbReference type="FunCoup" id="A0A401G6F0">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6F0"/>
    <dbReference type="GeneID" id="38774655"/>
    <dbReference type="InParanoid" id="A0A401G6F0"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="333"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="633" mass="70666" checksum="E0D3A77F09752F80" modified="2019-05-08" version="1">MAVPNRPATHTAQTQLRPNVTDDYERWYTESAPNNRMLLSLRSGIDSEVTWALDRLCRLCNNEQFVLRAIPGLTDALFEWPDWYVGKGGEECTRMAALFALPQDLEKMQRHALESLFVLRNSAVNEPNADELSGHQRTRALILLALHNVKPDSDANTEFLLYIIELLQAIAPTSVLPPPDAPATANPIPPLRELAGSTSNRSLIIASLSTLSMILSNPPNLVHLTEDSSALKAAIRVLPLFVDKPLIEAAMNYLYTHLSYPPMSKAFLLHPQMPATMKLLVSFILSEQIEEIVSVGIGGPVHTALAQVVSTKDHELTQEELDRLVPMPEPQRCYEWMKTMFVAKPDGELTQVDFWNLYKDVFTPYQDRYHLLVASDVIKNVNLVFTQAQAMVLPGPPQRFVVRGVDRRKELSAMEQFRCLWDRSQCSAAVFGSTGELYEHILQQHINTHEGSELSCSWASCTHPPLTRAHIRGHVLTHLPNMQESPRDPSQSDVITLPSEDFPHPTNDPTTRPAPPPRSPSINYKRPIVDPPSSALTALLCMRLLFRASFASSDAAPRVDEDHFGFPGVVEETEDKEAAMELSGGTESEKEGERRGRKAFMGIRHLLEGVRIRDDALMGWITEMVDAGITGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6M1</accession>
    <name>A0A401G6M1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">37S ribosomal protein S25, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0106810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608712.1">
        <property type="nucleotide sequence ID" value="XM_027752911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6M1"/>
    <dbReference type="FunCoup" id="A0A401G6M1">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6M1"/>
    <dbReference type="GeneID" id="38774716"/>
    <dbReference type="InParanoid" id="A0A401G6M1"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="294" mass="33996" checksum="296C53A35AA57D0D" modified="2019-05-08" version="1">MSKRVASQVHKQASRLLRQNYLRREPLWYQAVLDHPPLPLPAKNPPPRTNYDLPTKNTHVKHASSGRTRIEKPHPLPVQYVEDEIRRQFFRDHPFEAFRPTTLLEGAHIEDEHPIQGKEWTRLRQRGRNPTPEDAIRYAANLHLHHDQPLTNAYTSAVAQFRSLRSEQHIARSYALLEADYYGLQLGPSQVDIAFEREGKALETWEKTREQDANENAARKRWKAIVESALPGSWTKGQEYVRLWQEGIRPTYAPLLTERTLTRAGVTSTAFTTEEKTSFKKDPFALAEAIRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G779</accession>
    <name>A0A401G779_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription initiation factor TFIID subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0109070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat TAF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608938.1">
        <property type="nucleotide sequence ID" value="XM_027753137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G779"/>
    <dbReference type="FunCoup" id="A0A401G779">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G779"/>
    <dbReference type="GeneID" id="38774942"/>
    <dbReference type="InParanoid" id="A0A401G779"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="10">
        <location>
            <begin position="139"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="517"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="565"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="607"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="649"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="691"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="798" mass="86550" checksum="D1D1FA7228B15560" modified="2019-05-08" version="1">MSVSTPPVSTPEASSSAAIPPPAVADPSSSSSTIDRLVLDYLRTRGHKAAEQALLESLNTSSPDDGNKPEASSSTTITPEELVKRLAVYAQKPTRPGENAFKDTASVLQELAAMNNPITIQSLIASLGPIGAEEILSLDPTDKQEGFRELEAWVDGSLDMYRPEFRPILFPIFCHFYLDLIQYGFKEAALSFLSTFSPSLSPIHAATLHHLSTLLLPSHVQNDELAQRFRNEKYTIRMSRSGFGLLLGWLTEGVGGEAPGLGEGFTGEKGKRGRAAVMRVVNNHLKFDVTSSTTSAVSPTAWEESTGLLSSIIPRANGSTQTDPHTFNSSKGELKLGPAPVSDELRSEAERVLREQAMVDRDPGAQYDLHYARPVPIAGVVAPAISDLAPHPPSFMTVDVKREVEKVRDARKRIRLEPSALSNVNINTPQGAVARSRALPSICAYTLHDVGEGAPCCTFSQDTSLMAAGFAESYIRLWSLKSEKLKGYRSDFQSNTVRDAASLRKAREKGGSTTRKLIGHSGPVYSVAFDPVGGSATPPRYLLSSSADATTRLWSLDTMTNVVAYRGHQNPVWDVQWSPMGIYFATASRDRTARLWSTDRTAALRIYAGHLSDVDCVRFHPNSLYLATGSSDWTARLWDVQKGSCVRVFVGHQGIVSTLAFSPDGRYLASAGEDLAINVWDLGSGRRIKKMTGHTASIYSLAFSAESSLLVSGGADWTVRCWDVKSAGGLQGKTRENGVNGFGASGMEVNGDQKEEESIETTDLLATFPTKRTPIIDVHFTPRNLCLVAGPYLSPEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G870</accession>
    <name>A0A401G870_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0112650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609293.1">
        <property type="nucleotide sequence ID" value="XM_027753492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G870"/>
    <dbReference type="GeneID" id="38775297"/>
    <dbReference type="InParanoid" id="A0A401G870"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16537" checksum="B69B03228E476B6E" modified="2019-05-08" version="1">MTSSLQVTQVWRGTDSEGNILPLHWALVVPTSGPDSDPVGNLYNAAGNIDTFHYEELTNVSLKNINWRGSLVVCNFPTDALHVVESILRRTPVVRHDYGWNCQNWVWACLRQLRRSGFDVRPKITWEGLRAEMFKLLEAWEAGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G881</accession>
    <name>A0A401G881_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0112710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609299.1">
        <property type="nucleotide sequence ID" value="XM_027753498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G881"/>
    <dbReference type="STRING" id="139825.A0A401G881"/>
    <dbReference type="GeneID" id="38775303"/>
    <dbReference type="InParanoid" id="A0A401G881"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="420" mass="46621" checksum="71CCD19E61E4C736" modified="2019-05-08" version="1">MTTEMKKLNVLMCGAGEYTTGWTEKGASKSDKKIGVVGLTLFDLRRLGKVDQLSMVGVSGAKFPAIKKHFEENIAGVYKDMDVSFESFPKADNYNPVAYKEAIDKLSPGDAVIIFTPDNTHYPIALYAIEHDLHVLVTKPAVQLLPHHNALVAAAKKHNVVCFVEHHKRFDPVYSDAKARAASLGEFNFFSAWMSQPKSQLDTFRAWAGKDSDISYYLSSHHIDIHCWIMQGRAVPTRVVASAATGIATSEPYNCVPQTEDTITLLVDWQSLSSSKHRGTAVYSASWTAPLKSGVHSAQQWYYMAEKGEINVDQAHRGYDIVQDETGKAWYNPFYMKYSPSESGHFDGQRGYGYISIEKFIDAARSVNAGHVQPSEFDGHGLPTIANTVLTTAILNAGRISLDEKRPVNIKHTNGEWILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8Y9</accession>
    <name>A0A401G8Y9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0115200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609544.1">
        <property type="nucleotide sequence ID" value="XM_027753743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8Y9"/>
    <dbReference type="FunCoup" id="A0A401G8Y9">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8Y9"/>
    <dbReference type="GeneID" id="38775548"/>
    <dbReference type="InParanoid" id="A0A401G8Y9"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="195" mass="22699" checksum="78E7767E919167E4" modified="2019-05-08" version="1">MVNLRSQKRLAASVAGVGKRKIWLDPNEQSEIGNANSRTHVKRLIKDGRIIIKPTTVHSRARTRDLLAAKRKGRHTGPGKRKGTAEARMPTKVLWMRRQRVLRRLLRKYREAGKIDKHLYHSLYQKSKGNVFKNKRVLMEFIHKAKAEKTRTKVLSDQMEARRIKNKAARERRAVRVHEKRQAIIAVEHEDAVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9G3</accession>
    <name>A0A401G9G3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0116940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609714.1">
        <property type="nucleotide sequence ID" value="XM_027753913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9G3"/>
    <dbReference type="GeneID" id="38775718"/>
    <dbReference type="InParanoid" id="A0A401G9G3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8289" checksum="81E8A7152CEB52C3" modified="2019-05-08" version="1">MSWKSEAEGGGRCDDRGAVIHRGGPAREEEGRRRVQGGGVGCGEASQGLRDREDEAACRCRTAVAGATKTWLQNVSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Q8</accession>
    <name>A0A401G9Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0200990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609815.1">
        <property type="nucleotide sequence ID" value="XM_027754014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Q8"/>
    <dbReference type="STRING" id="139825.A0A401G9Q8"/>
    <dbReference type="GeneID" id="38775819"/>
    <dbReference type="InParanoid" id="A0A401G9Q8"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="356" mass="39243" checksum="E657CBBF0813217D" modified="2019-05-08" version="1">MPSLTSFPPFPDNVPTHPLLVVDYTLLKAGDKDEISKLWKAATELGFWYLKNHGTDELVNQMFDMGAETMGLPLDEKMKFEQGDDGMSFGYKAAGANATDETGALDTVEFVNIAKDDALSWPTPTHRTYPMTVNARMEPTIIPFVKKSIEVNNTVLEIFNAQLGLPNGTLLRKHMLGEPSGSEARCIKNPPRPNGISEEKAALGAHTDFGSLSFLHNRLGGLQVMVPGTNEWQYIKPISGHAICNVGDALTIFSGGVLRSNLHRVVSPPGAQGYYERWSLVFFTRPGNSVALHALAEESSLVEEAMAKVQDTSVFQTNVTSAEWFARRIKNQRTKNQKGVETWRASRGTEHRPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA39</accession>
    <name>A0A401GA39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0202060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609922.1">
        <property type="nucleotide sequence ID" value="XM_027754121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA39"/>
    <dbReference type="STRING" id="139825.A0A401GA39"/>
    <dbReference type="GeneID" id="38775926"/>
    <dbReference type="InParanoid" id="A0A401GA39"/>
    <dbReference type="OrthoDB" id="3176940at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="2">
        <location>
            <begin position="205"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="489" mass="56177" checksum="E913B977318D5D84" modified="2019-05-08" version="1">MQDPHDIDEKFKVHDSIFLDASFPSTAKALEDEKTEIKDSKLQIGAGVLKPEERTSSLLDRTRPTAYDALKEEEREIKEPLKKNRRLVAEVLLTPWRDIKRILKERRGTALAEQNQAASASQDETNASPPIAVKDEPVEVGASSMVKKEEMTVEEIDEAFRMMVDPDVKIKKDSKFSYEFVRDRLKAVGFDIYPIPLDLESTKLMFPRLYISQLYGGSFVNTFPKISEERLALHGIDDFMCLHTDYNPHAPTTAGSNGLFFTRQRAEGAWYRPHPMRVLVLCAEGRWRYVGQYALFPSESLTTDEFSTQTDKVKKRWSEEMLKKGWGEQVRMRVYLRRIQVEFSDAEVMELCKDKPFLRKITAKLTWQDIMRAYEVGEEEIGVWVMKCVGYDVKFQKFLINNFDMFVSSMEKAKRGGRKPKTSGRTQRGKKKSSDQTAPKTGSKRKRVVDSESSDKSDEDVDEEGEEEDEVSASRNPSTIPEARDRDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA64</accession>
    <name>A0A401GA64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0202360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609952.1">
        <property type="nucleotide sequence ID" value="XM_027754151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA64"/>
    <dbReference type="STRING" id="139825.A0A401GA64"/>
    <dbReference type="GeneID" id="38775956"/>
    <dbReference type="InParanoid" id="A0A401GA64"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="68990" checksum="2A95FD4B0EF4341A" modified="2019-05-08" version="1">MLSLLSSARLPTVHSLVRNPSSVRWASNAPKRLKRWLALEFASYPLRIRKLLLKLYPYVESGQHGIALQQFQLTVSKGAFDNPSRFLAYEGAVSLFLRHGHVIPAAMMYSRMITDGFIPSVSLRTQMFIIAAAQESPSEDELLDALGKLFSHKSFNERTLRHVLHLLVGTMNCTPEFIDSVVATFVRTRTDLGYILAKETRSFLVHIHARAGSAASARRWASGDFVGQPEKVADSLQAESDIGRPKKDSPAPYTSLIRHLAPAEVTGATSKWTVAHMADDAVEPDLAFCNAIIATEVSQHYVDQAFQIYQVLLDDDTGEFLPDAYTFSSLFRAMCIKKQRRSVRTRRSPPSVAVRTPRALYREMLQCHARQAQSVVPRRSPVITSDVLHRALRTFLLAQDYAAVFVVLRTFRMCKLLPTLRTFRIVLAHLVHRVRSELPAAARMEYPEELWAFRFLGYPPVGVIQGLPVTETVLQVGAVPRLSLKFIPPASEDSTQAREEKLIRSISPSSQDSTQAADRKLTSSSALPARPQSITSSSGTPDQQHVVPSVLDIVGETAPPQAIWDATPLERILRRAILAQTRYTMTTTPARIVSGAIADAKAAMLPNEWTKRRERRKPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAZ2</accession>
    <name>A0A401GAZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0205360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610251.1">
        <property type="nucleotide sequence ID" value="XM_027754450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAZ2"/>
    <dbReference type="STRING" id="139825.A0A401GAZ2"/>
    <dbReference type="GeneID" id="38776255"/>
    <dbReference type="InParanoid" id="A0A401GAZ2"/>
    <dbReference type="OrthoDB" id="2693038at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="495" mass="50873" checksum="BAEF0A43B6A6D168" modified="2019-05-08" version="1">MSVLHLIRIDDLSDSGVFVSSDTFGGNDGNNDGGDSGGLGGQLSSLFSPFFPPNSQSSQSSILTLSASSTPSLTSSPSPSDAPQPQPTSSENVSSAASNASSSSFAAASDTASASDTVSASPSATASGSPFPAPSGPSDSASSTVSSTASASHTGSASSFAAAAATSAPPKSFLQNKALSVGVITAASLIGLVLLIVIATFAIRRRRRDKLQPDAVDFDPDASSDQLVGGGGDVEHGNRPRISRERRASKGTGSNESSQAESSPAGPSYGQTVVNQNSEMFERTGYPALPVFVPAATADGERYPTMGYSSQSAYPAYNTNTYEHGYPYNALLPTTVGPPRGQGPSNLPYDTTYPRTLHPPQRKQVPALIPLDIGATTAPQAHSNSGPPSALSIISLSASPLRAAAMENSANPPAYSSVALPPPKRSSQLRRVSASPMESSLTSGTIGDGQGMVRMDPTLPQIPVFALLPDEFGGTLMQEIQSDEKRARRFTVRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB28</accession>
    <name>A0A401GB28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0205550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610270.1">
        <property type="nucleotide sequence ID" value="XM_027754469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB28"/>
    <dbReference type="GeneID" id="38776274"/>
    <dbReference type="InParanoid" id="A0A401GB28"/>
    <dbReference type="OrthoDB" id="5522061at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18799" checksum="0BDEE44465BF7877" modified="2019-05-08" version="1">MSCAARRRCTALQHSCRRLYSSGVAKPSRTSRKTLTETDSCGIPLQPTWSVNELLSSYPQPVITPSTLQRLHALSALIPPAEGTPEHETLTREMEEMVRLVEAVRLVDTSEVAGKEGDIPDGRIWAEGVGIDISEAAQIPVHDGEINGRQLLQHSSRVSNALYEVNSQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBD8</accession>
    <name>A0A401GBD8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0206880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610401.1">
        <property type="nucleotide sequence ID" value="XM_027754600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBD8"/>
    <dbReference type="STRING" id="139825.A0A401GBD8"/>
    <dbReference type="GeneID" id="38776405"/>
    <dbReference type="InParanoid" id="A0A401GBD8"/>
    <dbReference type="OrthoDB" id="2728997at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12623" checksum="688AC6F2BDA401B3" modified="2019-05-08" version="1">MDVDRVNISCLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMQEDLAQKKETLKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBZ4</accession>
    <name>A0A401GBZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0208750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610588.1">
        <property type="nucleotide sequence ID" value="XM_027754787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBZ4"/>
    <dbReference type="GeneID" id="38776592"/>
    <dbReference type="InParanoid" id="A0A401GBZ4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="73" mass="8421" checksum="986C15FF594E77A6" modified="2019-05-08" version="1">MDEMTRSGEKKARERCWDGLIAVPEEREARTFDRRIFLKLRLTTGHETDDGRTVCTKMTVDDEVVKGSRPHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC52</accession>
    <name>A0A401GC52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Glutamine synthetase</fullName>
            <ecNumber evidence="4 13">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0209220</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>L-glutamate + NH4(+) + ATP = L-glutamine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="4 13"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610634.1">
        <property type="nucleotide sequence ID" value="XM_027754833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC52"/>
    <dbReference type="FunCoup" id="A0A401GC52">
        <property type="interactions" value="500"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC52"/>
    <dbReference type="GeneID" id="38776638"/>
    <dbReference type="InParanoid" id="A0A401GC52"/>
    <dbReference type="OrthoDB" id="1936100at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000004">
        <property type="entry name" value="Glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050292">
        <property type="entry name" value="Glutamine_Synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20852:SF57">
        <property type="entry name" value="GLUTAMINE SYNTHETASE 2 CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="14">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="15">
        <location>
            <begin position="106"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE79721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="38937" checksum="39B9337768C9FB23" modified="2019-05-08" version="1">MSYRPELLAPFLALPQGDKVQAEYVWIDGDGGLRSKTTTVTKKVTDIGQLRIWDFDGSSTNQAPGTDSDVYLRPAAIFKDPFRGGDNILVLAECYNNDGTPNKTNYRHHAKKVMDLAKEQVPWFGLEQEYTLFDTDGTPYGWPKGGFPGPQGPYYCGAGAGKVFARDLIEAHYRACLYAGVNISGINAEVMPSQWEFQVGPCEGISMGDHLWMARYLLVRAAQQWNITVSFHPKPLAGDWNGAGCHTNFSTKAMREPGGMAYIEAAIEKLSKRHNEHIAVYGEDNDLRLTGRHETGHIGTFTSGVANRGASIRIPRHVGAQGYGYLEDRRPASNIDPYRVTSIIVETTCLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDI1</accession>
    <name>A0A401GDI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0214010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611104.1">
        <property type="nucleotide sequence ID" value="XM_027755303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDI1"/>
    <dbReference type="STRING" id="139825.A0A401GDI1"/>
    <dbReference type="GeneID" id="38777108"/>
    <dbReference type="InParanoid" id="A0A401GDI1"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="7">
        <location>
            <begin position="26"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="35057" checksum="B7C853DC3AD31BAC" modified="2019-05-08" version="1">MPRRVLIGFGVDVDAVSGWLGSYGGEDSPLDISRGMYSGEVGVPRLLKLFKKYNIKTTWFIPGHSLETFPEQMAAVRDAGHEIGLHGYSHENPVAMTLEQQKDILDHTYKLLTDFNHGVPPKGSVAPWWETSSEGTDLLLDKGIEYDHSNMAHDSQASYLRDQDRWTKIDYKARAETWMKPLIRGKQTGLVEIPANWYLDDLPPMMFIKSSPNSHGWVNSRDVEQLWKDMFSYLYREEENFVFPITIHPDVSGRPHVLLMLERFIEWVNTHADVHWVRMIDMANEFRANNAPPAGARMPAGFQNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEA5</accession>
    <name>A0A401GEA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0302270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611425.1">
        <property type="nucleotide sequence ID" value="XM_027755624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEA5"/>
    <dbReference type="GeneID" id="38777429"/>
    <dbReference type="InParanoid" id="A0A401GEA5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11351" checksum="DE00A3EF9175FC86" modified="2019-05-08" version="1">MAKRIAPRLYASLPHSIYTLSTYYSRLTPYSWTLMGLNGDHTTTNRLVVAALNAEPTHGAANQAIHGSKMAGDPDALLGTFTFIDNLSTGDGFERRTPILLLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEX7</accession>
    <name>A0A401GEX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0304390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611633.1">
        <property type="nucleotide sequence ID" value="XM_027755832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEX7"/>
    <dbReference type="GeneID" id="38777637"/>
    <dbReference type="InParanoid" id="A0A401GEX7"/>
    <dbReference type="OrthoDB" id="2691931at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="470" mass="53446" checksum="190067A485D78455" modified="2019-05-08" version="1">MSLVKFSVLVEGEVISVQMERREVVMEIYHWIRSFSVPLKNKLALLTVTQLTYFKLKEPVRNDAPLESRVAEGNLEPLDSNTRIEQFAEQFKVGFICVLVKLPPDETGIAIEQLQQNYSDLFSRLQITVAHPGRWSADDIRESGGVYVGGNQPTPREISDIETKLTRKRSYRESSSEYLRIALTYRDHFSSIFEPSLAGSVDVQNDGEFVAFCNALCCYRENSEKIAQNISSSLKASSFAVYFIHPPFFSWRPPQDPLEYKEQLSWNFPMFIATCGMAEPWRKFTPDSDFGVISRTHLCPFVISDVISQKHEQDRHRMLLEAIVAARTGSYLLKDRSQSRFFVVAVYLAASLCASRYIVTEADSGRQVHIARADFDLTDANAAVRFFGEMCNLSQLLGELAGELDELKRESLLTIQQVASKMRSLNHRRRARRSTRPSLSSNSDRSGLQEEDDLGIFHQQRSSPVGCRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEZ3</accession>
    <name>A0A401GEZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0304590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611653.1">
        <property type="nucleotide sequence ID" value="XM_027755852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEZ3"/>
    <dbReference type="STRING" id="139825.A0A401GEZ3"/>
    <dbReference type="GeneID" id="38777657"/>
    <dbReference type="InParanoid" id="A0A401GEZ3"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="190" mass="20839" checksum="66DBF6A0B5AC889E" modified="2019-05-08" version="1">MDLPIYYTRAEYIETDTGNKVSRRATIAGPQNIILGGKTIISSGAIIRGDLRRTGPGHAVVISLGRYCLIGEGCVMRPPYKTYRGNFNYYPMKIGDYVHIGANTIVEAATIGNHVEIGKNCVIGKFTIIKDCAKIADNTIVPPNTVIPALALFAGSPGRFVEDLPESTQEMVEAQTKQYYTRFQPLPAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFJ5</accession>
    <name>A0A401GFJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitogen-activated protein kinase SLT2/MPK1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0306650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611855.1">
        <property type="nucleotide sequence ID" value="XM_027756054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFJ5"/>
    <dbReference type="FunCoup" id="A0A401GFJ5">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFJ5"/>
    <dbReference type="GeneID" id="38777859"/>
    <dbReference type="InParanoid" id="A0A401GFJ5"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07857">
        <property type="entry name" value="STKc_MPK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE80942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="437" mass="49186" checksum="FAA488C1080572E8" modified="2019-05-08" version="1">MQRHTFTALNSTFIVDSEYQFVKELGQGAYGCVVAAKHRRSGEGCAIKKITNINTKRILTKRCLREIKLLHHFRGHKNITCLYDMDIVFRPDGNFDEVYLYEELMEADLHAIIRSQQPLSDAHFQSFIYQTLCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGYSPSGGSARQAGNQGFMTEYVATRWYRAPEIMLSFANYGPAIDVWSVGCILAELLAGKPIFKGRDYVDQLNQILHYLGTPSEDTLRRVGSPRAQDYIRSLPIKPRVPFATLFPRANPLAIDLLSQLLHFDPAKRITCEQALNHHYLAVWHDPADEPVCPSSFDFGFEDEDSIEGMKRLIVEEVQQFRSEVRAQARAAGQIRRQDSLPMPSRDEILNSPVLENAPPNGATSGFTAPKQERPASPVMDDPSAELERELAGTHIGRKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG47</accession>
    <name>A0A401GG47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0308900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612077.1">
        <property type="nucleotide sequence ID" value="XM_027756276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG47"/>
    <dbReference type="FunCoup" id="A0A401GG47">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GG47"/>
    <dbReference type="GeneID" id="38778081"/>
    <dbReference type="InParanoid" id="A0A401GG47"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1132"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="5">
        <location>
            <begin position="567"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="765"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="350"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="887"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="418"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="887"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1172" mass="127404" checksum="0E881772F463BC1C" modified="2019-05-08" version="1">MSSSSTTACSRSPSPSPATPDSSDTLEPVVTQEELVAWCNSLSSGFLVGDEAQFLDNDKREQGQILDLEDLLQVTAYEDSPPPAQEYKFPSPDSAALSGASSPSSLEISDLLARPRGSGSMKPIPPPPSQPRRDPSIVAQRVVYPSKDSCYNLPILIPSIPEGGTKSRVETQVRLTVDLAHASASSGEPFKYDRVGSWKWLRLPKGTSTKRRTRKEGKVETQVDDTLYLTAEVTCASSPHTPVTCCASCQTREAKRVARKIAARVRPARSDSDSPDEARTIPGRGKHEDTSNLLQFNCPEVMDFSTGSVVLPLRITCYCRHHREKVGFNVHFSMLDRTGRIVGTGTTRPIMITDDHKSTGVNSKSATLLGGFERSQIDRSSRVAGDSEKRPTKRKIREGSDRTKKRTKPYDVGRSAGRGSQNTSDGSLDSPKTPSSTFVSRPTSPLHSLASSVLSQPGPSRQLTSSRLDHSRTHSASTAVEPVFDISQSVGQLSSTRFDPDISLPSQISVQSVSLDQLANSFLPTTPSSPIPLALNPVQTLNVPRPPSMSFTLFKHDPPPSISSLPPPRIHRLIPSSGPTYGGIEVTVLGANFHTSMQLNCVFGGSPASSTQRWSDNTLVCLLPPSTNPGVVPVWFDGIPKEENGTPACLFAYTDETDRALMELALQVVGLKMTGKIEDARNVAMRIVSNTDSNDSGSGIAASDAMQLANDSATRSLDIRRVLLSRAGDNGDFESLILDFLSILDVPVPVQTASLSSSISHQSGSGQTLLHLATFLNFPTLVSFLVSHEIDVDARDRNGCTALCLAAIVKSTQCAKILTDAGASFDIVNAWGKTPAQIAPSGFFDFVSSESGHTDQGCDADDSLDDESAWGDVEDHTDDEVEVKQVRRHHPRKFLHRMRKTIHPPAESDKDTEQRPAATQKSEEKKELKLQDEKQAVAPFMETLFRTLAQLQHPQGMIPNMPNLPPLHLPQIRGIPGIPAWNALSQMPAVFPVFVPIPALSAIFGEKRAGEVQSEGTPGTNGQAWLGMLTVQDWRAIWEKWMTQVSMSAKETTEFPPPAYTPRSEGTDATAVEVREDDLPSVGASSATADRVVARHVGYNEDMPIPEQEVNAYAYRPARKPSRRSQKKSDRMLVLFWIPILLIGVAWAFLHFARVAFHATRAVVGYKAGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG58</accession>
    <name>A0A401GG58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0309040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612090.1">
        <property type="nucleotide sequence ID" value="XM_027756289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG58"/>
    <dbReference type="GeneID" id="38778094"/>
    <dbReference type="InParanoid" id="A0A401GG58"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="388" mass="41492" checksum="A36F549A99AEAA7B" modified="2019-05-08" version="1">MMIAPTQNNTAIPQHNIAPSERLGGLLRVTFDKQPTVILEQDQLVESPVESDDHPSQHHVRPDSPSTPPSSPPPPPRPAPMELPPSPLIPSPPFVLRQPFRGPTIASPLYTTQGFPQPIPEDEIRFVPPLVGTTPSLPRLPCQKTSSLPRVEAHTNVPSTPPSSINATHRGVSDVNLSFLRRLPILFFLLVIWLAHLLVSAASCAFQVCLGLTLGHVVLHVAWPLNAAYAVDVGRTIAAGAVGGAVVAIPMSLIVFILGCVAHAQRQLLRQPDEEAATLNRSAKPHTTDLEADLAEEAETSGQLGLWRSLLVLVSYTLVGALAGPLGSSLLCGRMGGEILSGVHAMAAGALGMFLLSVSVICGMRVEGKRIGQDVRWGVRCYIFRGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG92</accession>
    <name>A0A401GG92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable intramembrane protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0309270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612113.1">
        <property type="nucleotide sequence ID" value="XM_027756312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG92"/>
    <dbReference type="FunCoup" id="A0A401GG92">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GG92"/>
    <dbReference type="GeneID" id="38778117"/>
    <dbReference type="InParanoid" id="A0A401GG92"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="404" mass="44381" checksum="6369F2C17F607321" modified="2019-05-08" version="1">MTDWDLLSSYAGLLTLATCSICAGSYGSLTARKSKPGQPVADKSTDDEEEEEIPERLSSADVYLFPILGSAVLFGLYLVVKFYGEEWINWLLQWYFTVTGVGSVSKSLVSLAKFTLGAQRWKKFDKLQILFLKGPKEVISISMRTPSWYIAPLGAIPSILYTFGPSTTRKSALLTDVLALSFSHNAISLLKLDSFKAGCALLSGLFLYDVWWVFGTEVMVKVATSLDIPIKVLWPKSLSFATTRGFTMLGLGDIVIPGLFVALALRYDHHRHSEASPRSRLKTPYFNSALFAYVAGLFTTMFVMHYFRVAQPALLYLSPAGIISFFVTAAVEGDLKQAWAWSDEPEDNSASDAPKAAPNGNAVTSTTPVINVAPIGPATVDVPEDVEDEEVEGKEKKKAKRRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGA8</accession>
    <name>A0A401GGA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0309540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612140.1">
        <property type="nucleotide sequence ID" value="XM_027756339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGA8"/>
    <dbReference type="GeneID" id="38778144"/>
    <dbReference type="InParanoid" id="A0A401GGA8"/>
    <dbReference type="OrthoDB" id="2813636at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="132" mass="13516" checksum="D8D32E24B23C0B48" modified="2019-05-08" version="1">MTPQVMQTSDPALFNDAFLAPNATQQATLNIPLFSLATPTPTASGASTGATSDSVAVETLPQFVLDAIAAAEATDSDPQALAAQEAARADGDRCIASGRSCTPDWIARPEMPRCCPGLTCYAVILAVGGWCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGD1</accession>
    <name>A0A401GGD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 5C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0309080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612094.1">
        <property type="nucleotide sequence ID" value="XM_027756293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGD1"/>
    <dbReference type="STRING" id="139825.A0A401GGD1"/>
    <dbReference type="GeneID" id="38778098"/>
    <dbReference type="InParanoid" id="A0A401GGD1"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="2">
        <location>
            <begin position="254"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="422" mass="47535" checksum="05DD554BD207FB46" modified="2019-05-08" version="1">MSQQSAAPKPSLQGVRIRARKGAVKAHAKHEPAVFRDQLYKHLETVPADDFDGLTNKLVQAGSTLEFLKYADALFEILLAGGLLQPGGSYVEEEVPPAAFSIVAAKEPADFADLKLHVEVVNKLVRRYKYLQRPLEESSLPTILQYINRWTEPQREKLAIAIGLLISQGLASASCLQSLTKDHLVKNDLSVTVITLIFRACLAEQSIDHLAGALKRGGIRDLLAFFPPNRREDRVLEEHFRRAGLPQVADWWTKRQFASLKDGVIKALQEMLQRDLPHREIVAAIKSRQEEQPLPETELIQCIWQGLISSIEWSARQDQNEALALREISGFADIIEPFCNGAKTEVALINTVQVYSYEDTRIIKAFPQVLKVLYNKDCISDQAIIYWHQKGAKAQGKQHFLQATQPLVKFLQEQEEESGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGZ8</accession>
    <name>A0A401GGZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612363.1">
        <property type="nucleotide sequence ID" value="XM_027756562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGZ8"/>
    <dbReference type="STRING" id="139825.A0A401GGZ8"/>
    <dbReference type="GeneID" id="38778367"/>
    <dbReference type="InParanoid" id="A0A401GGZ8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42645" checksum="05CB3CF68CADE0A7" modified="2019-05-08" version="1">MSSTLQQCISPSVGALTRTEEALKASLSSPAFLDVKFFAFSRKYVTADGTVRVDKPQPILAISSVLKKIEDLDKLLSSGFSESNSRVDLNSGYPGNETPYCDEYDYDSDSDLDYEEDVIDIVEESPADIHEAQGQPAQPSAQGNCRQIIIKDAAFHTWRAFIFYLYTGKIKFMQLKSRDEEARNVELALYLSDPNSVPPCSPKSMYRLADKYGLAELQTRAFAAIKERLSTANIVKEVFSKFTSRYDKIQELEIDFLCTHYTNPEVANTLKQIADGVVQGEFPHAGEVLRTLFELNLDPSSPSARRRSHHLNAVGAGRSSARGQVINFGVSRGRGARPAARGFVPPTLPVYAQPGGSRHDSWGGVTALFSPPAREDDILGENSDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHA4</accession>
    <name>A0A401GHA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0312340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612418.1">
        <property type="nucleotide sequence ID" value="XM_027756617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHA4"/>
    <dbReference type="GeneID" id="38778422"/>
    <dbReference type="InParanoid" id="A0A401GHA4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="102" mass="11407" checksum="DCE34E4BED650BBA" modified="2019-05-08" version="1">MPQAVQERHTVRDAHAQSGYLREYHRAGDFCLVVDGIVDRVSPYGFQSGPVFRIPDPGDHFEEAEHYDSYQGNDIGHILRKMRAKASSGMDDSLSLDVDVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI20</accession>
    <name>A0A401GI20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0401460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612686.1">
        <property type="nucleotide sequence ID" value="XM_027756885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI20"/>
    <dbReference type="STRING" id="139825.A0A401GI20"/>
    <dbReference type="GeneID" id="38778690"/>
    <dbReference type="InParanoid" id="A0A401GI20"/>
    <dbReference type="OrthoDB" id="3216420at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57456" checksum="29CBA55F8AF7C5AC" modified="2019-05-08" version="1">MSDSPDEFANYDPTTPYKPPPPKKPARPSRANNRPVAGPSSKPLAVPKKNGHSRQADVPDDKEQIVIASSSEDELKATQEEEEEVVVVPAPPKSRTARKTTGRRTAAVNGRGKAPAAKGKAKAARSATPEDDHMEVDDQQVTSIEEDEGAAQRSTHVRSNFKGTKVNTSAQRAHQEDSYLRDLEHVQKQLETVMSDRDKLSKQLEELFQVRHTEPEQALEQCVQQYEARVQTQETLIRELTSQLANVKALAGTEKSYMLHFLTREAADEEMETVQKEMTRWKDIAKQKDAQLAAKDKRIAEMEAQEKVLRSDLNAEIERGKSLAARNPPPVTRPHVKVADDPKNTAVLSLYEDMTNLLVVGVKFEKSPYLNHDEPVFACVYTHRQKGEDQGAVPSLNFSLRHTWERPDGLEPNVVITRKDQLEDKVKYQPLMLENESPKFVDALDFFKDPFMFSHGQLPIFLKTLTGKLGGDKESSEGDQLADDDEDEDDDDDDDVVEVIPACLNNSCAVRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIF9</accession>
    <name>A0A401GIF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0402750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612814.1">
        <property type="nucleotide sequence ID" value="XM_027757013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIF9"/>
    <dbReference type="GeneID" id="38778818"/>
    <dbReference type="InParanoid" id="A0A401GIF9"/>
    <dbReference type="OrthoDB" id="3059868at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="401" mass="44546" checksum="F0E5FBB628A27F04" modified="2019-05-08" version="1">MDFFKVSSTVPYNMKLQCNSHSIDPPSLPWCLLKNGMSPVHTLAVVLLLVSVLTAILCSLSSRDSDILLARRRQALYAILFLVTPTCSLWSAAYLAIARRAAASGNNIVRLPLRELLDDIVAGKMQLRDTGLDLPSLITSTLRVHDWLIVLRVELSWWATVLGWIAASHFSFIKSYSFVWSGSQFISDRKTSPSSSSFKTSSLTQTLHNLNGTRTEAVSLLPARGLSLDTVPYLHLEAFVRALQTALCPGSCISINFTARCTSVSFLSSSFVLTALPFLPRQRIHRGSRNTYTSQQLSSTSSDAVRTTTPLFASLSYVLDLITSGSMPLIVHSVRNVSEQQASSLNAYVRDLEEDAGVRMAFVRRWGLPGWREEMVYTSWEAALLTSRLLERWEVMAYKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIJ6</accession>
    <name>A0A401GIJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0403730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612910.1">
        <property type="nucleotide sequence ID" value="XM_027757109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIJ6"/>
    <dbReference type="FunCoup" id="A0A401GIJ6">
        <property type="interactions" value="339"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIJ6"/>
    <dbReference type="GeneID" id="38778914"/>
    <dbReference type="InParanoid" id="A0A401GIJ6"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="644"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="704" mass="79324" checksum="CC4C92CA295AC3CF" modified="2019-05-08" version="1">MKGLKKTLLSRNKSQDSTSSKHKDSKPSATAAANAAPPPPPPNSAKPLHLPASAVASLNHLAHNNSNHSLPSTNGTSRATPAPTPPAPNADRRYATPPNPAPPIVVVSPEVSSEQADRQMLSMDSAGGPLTPPRANTFNRLRPTGPKDTIPIVGKPPRKQRSSRFVVKEKVEIERLPPFLETPPSERSQLFIQKLHQCSVLFDFNDTNAELKGKQIKTQTLHEMLEYITTQRGVITESIYPEVVKMFATNLFRSIPPPVNPTGDAFDPEEDEPVLELAWPHLKIVYEFFLRFVESPDFNTNLAKRYIDQNFVLNLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAPIRRSINNVFFHFIYETERHNGIAELLEILGSIINGFALPLKEEHKTFLMRVLIPLHKVKSLSMYHPQLAYCVVQFLEKDATLAEDVVLGLLKYWPKVNSPKEVMFLSEMEEVLDVIDPTEFQKIQIPLFQQLARCINSQHFQVAERALMYWNNEYIVNLMSDNLAVILPIVFPALYTNSRSHWNRTIHAMVYNALKLFMEINPDLFDDAMQQYKQRKLDERQHAVERYDEWQKLREQALNNCGGKVPEGFVDQEPTPPPPPVEDVDIMDLAMDLSAVAIDAEGPLGDLDESGIERVPMADPGLDRPFPEVGEHSPGNLHSRRKSALPVDPTVLRDLQAHRSLEDAVAIGGPRAGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIM4</accession>
    <name>A0A401GIM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0404030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612940.1">
        <property type="nucleotide sequence ID" value="XM_027757139.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIM4"/>
    <dbReference type="GeneID" id="38778944"/>
    <dbReference type="InParanoid" id="A0A401GIM4"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="213"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="802"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="971"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1292" mass="141419" checksum="14EEE231800371F4" modified="2019-05-08" version="1">MAGWEPARVKSQLRLTAQRLGQLQDKLEAQAQITRRDIATLLQQGNVALARAKAHKLINEDASGDLLQTLEMHVGVVLGHLNEFERSEPPSPVLVEAASSIIYATPQTQSRDLQVVRDLLIHRLGPDFARSAAGNRDHYVSSRVLRALSAPPPSAARLDQYLFNIARAHSVHWMPDIQPHEKVNALSEMLDPSTTPVIDMTRLRMLCSHGLPEYPSWLRPRIWRLLLGTLPVEKSSWGDETRKNRESYYDLVRRLLEPFSSLAPPASPLGPLDASLMDVSNELSQVPSNLLGGLQEDPEALALCPLDSTASEDIKISCAENLTSRLRVLREAESADASDDVTPEIRLEGTPEIRLENPEDNPGVKTTAEAPGEKDGASTPVTPGLSTPGSPTSSNSGPHTTLLASRTYSAMGTHQKHASALLRLLYIHYCLNPANRSPQIASLLVPIYSALNEEVEVQDLAHVEADTFWVFEAMIGEFAELEDEGNGNLWTRKLGERLEWADPELAANLQTQGLDPALPHYSYRWLITLLTHTLPLPGVLMVWDALFSRPTRERDANPKLDYLTDTCTSMLLCAKSALLQLGKRRIKPDLWSDENAAIRSTSSGARELEDAFAEGMAFLQQYPLEKVGGIENVLQTAYDLTLQREAEANAVNASKTSIGARLRDTMWRGFANQGPTLETHVEEDSDAESDEYEEDEHKTDQSVNAGAPTLTARLANTVWRGISNQSAMEPPPSPEPPASPAELVAPPEPEIPPKDVPTTSLPARGRSMLFGYAEKFKESDAAATLAKVSTNWRVKAMDVWSKRASGSHVTESAPPTPPPPPPARFKPSSVDFDMKRRATLQEEKAKVDNRRSSVPTADRSSLYSPPERPAFFRPVRDSIVLPQGQSLLSPISPRSDEVSPVSDTGSIGSASGRKSGPRPLLLNSASLITAGRPTGHSRSPTNSSLSLSTDQQWAEMVRAKNRHSPVHRDSQSSLSSASPADARRSQPRSATRSDRESDGFGSRIVPLRSSPSPAARESRISTIHVKPASPPVQHRRTSGEISQHGSDDSQSAKGWGRVDVPDSPATVPSPPLPHTPDTSVTNTNSGVQVKDSEPQRGSVVLTQSSAELPVKVQEFKLSRRPSVFPRMPEDENNSDSSTTEPPSRMPRIKSRRYPPRLASLRARENTKTSTNEFGQKTLAPELPDENDNATTPRATTFEDATVEPTPASASPRPHRRVRKNSGEANSETRTRKVSNDGRDARVRKTSGDGNIRVRKVSGDRDDAKLKRVDSAAVEGDDEGYNELLSAYESEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIS2</accession>
    <name>A0A401GIS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dbl domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0403870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612924.1">
        <property type="nucleotide sequence ID" value="XM_027757123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIS2"/>
    <dbReference type="STRING" id="139825.A0A401GIS2"/>
    <dbReference type="GeneID" id="38778928"/>
    <dbReference type="InParanoid" id="A0A401GIS2"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF7">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="276"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="844"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="893"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="859"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="955"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1038" mass="112894" checksum="322169E881C20FFA" modified="2019-05-08" version="1">MKAFINRFISKERDRDKDGCKEKIPHLPPLIEWPPQRATSTPSSVGSSKPLPDLSVRPLPPIEEPSSTDSSSTPTPIAPNTPLPSAGPSQDVAPDSSKEPSGTPLPRSEHDSAGRSSRKTTNASMSTATGNSTDIQKKVAFLSPPPTPGPTSDRSLPDVEASTSSASATAPMKSTVSRFQANHVKETRGSTSTAASSRTDVTSTLKANKQASFARATTSPYPQKNLGDGASIHQSLRSGTPYSQMSNTSSRILSASSWSEVAEEDLVSNIGQRERTRQEVLWEIVASEERYVTELLKMKETFIEPLLHPYSAPMPVLSPTPLDYEDYSHSDTPRESLENLPIASRFLSPVGFLSDSPAPSTPKDDGHPNIDGESMNSAEEDEADDRMGAAYHSSRQMSTAAKHSHPRSPYGTSAMRSGAGKFGTAVPFPSRSHQSLPPPVRPNPLASSTQSLGRQSFMTERGGDASKSTTTGGSNVLRKFKRSNAAAAVVNHAVPSAQLPEDLRICLEVIEGGILDGNLRLSDGLRKRYDEQYPLVRSLADVFVSNSHILHGYATYVLHLERALEQVDNALSNASASKKPKKQDADQWMKICQALQRLEVIASEKGETGLAISLSKPFQRLLKYPLLFQNLLFHTDPSTFEYESTLQMVAEVETIVRSIEDEKIQKEERDKTRDVFARIEGLDKVKQLMVPKPSRVLLEERPVVGINPLTDPTAKPSGPPPVSQNPKAVRGKTSFKRLSDVLQSGNNGIGGKKDLWLVVFNDVVLRCQRTGTTSLPLVAATNSRTNSLPELQGKAKYATTGRRSAHTKPRNMYKFIKIETWAIGEVVQPREGVVSMEDVVRSRQQVHSGVPQPRIVPLPDDDEEGGESDDSDRKSKMSFSYWGADKVTLQKPLVKARVPSGNGTRRGAGVTATSYGRESSANAKFGTRLVSGESPNTARPASRRTQATPVNRRQPHSDENHSVKATVTRERPAWDGSTRSPISTTPVPKRARNTSQTSAATRTNVPNKLSSPAPSEDSGVGFYRQIVAQNPSLNRLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIT8</accession>
    <name>A0A401GIT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SCP_0405000</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613033.1">
        <property type="nucleotide sequence ID" value="XM_027757232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIT8"/>
    <dbReference type="FunCoup" id="A0A401GIT8">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIT8"/>
    <dbReference type="GeneID" id="38779037"/>
    <dbReference type="InParanoid" id="A0A401GIT8"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019205242" description="triacylglycerol lipase" evidence="19">
        <location>
            <begin position="19"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GBE82120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="425" mass="46875" checksum="B7A894BCA47B7903" modified="2019-05-08" version="1">MRVLQLFAISFLLGTSVCAPNQTPISFVSQRDLSLSHVSDNYDAQPVFDVSAIGVLPSTPTITLQARPTTIWRPRSTAALLRARLRSLYDAEDEEVEWEQVEVLGPDVEDKHTISQLARMTGNAYALPEQKNWYDMDPAWNTSFPFGWEDSADGFRGHVFVSSMSNTVVLAIKGTTLQGPTSKKDKFNDNLLFSCCCARVDLSWIFSTVCRCYAYKWRCDNTCLRDALVQDSLFYNIGVGLVNNLTDLYPTANIWLVGHSLGGSLASLLGTTFGLPSVAFESPGERLAAQRLHLPLPPSSDSVTAYGSAPVTHVYHNADPIPQGACTGPYSLCTQAGYALETRCHLGRSIVYDTVGKLGWRVDVATHRIAQVITKVIEADLDSGWVGEDGIEREVPIAREEVDCVDCYKWEFGDYKCHGLHCNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIV3</accession>
    <name>A0A401GIV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0405140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613047.1">
        <property type="nucleotide sequence ID" value="XM_027757246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIV3"/>
    <dbReference type="GeneID" id="38779051"/>
    <dbReference type="InParanoid" id="A0A401GIV3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019573390" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10445" checksum="3325CC996DA69F98" modified="2019-05-08" version="1">MRNRVALCTLPLIGFSLRCIAGDVVVESDETGAVDLAAMVAAGTPKASFVALAVSSAPDVLMDWYRLISHADDSPLLKMLAGWEGEDVDRKLLNIGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJK7</accession>
    <name>A0A401GJK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Long-chain-fatty-acid--CoA ligase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0407290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613258.1">
        <property type="nucleotide sequence ID" value="XM_027757457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJK7"/>
    <dbReference type="STRING" id="139825.A0A401GJK7"/>
    <dbReference type="GeneID" id="38779262"/>
    <dbReference type="InParanoid" id="A0A401GJK7"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="89"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="692" mass="76773" checksum="6BC8CC4F1A85E135" modified="2019-05-08" version="1">MTMKEYIKYVEWHKDQLNYDKQMVEVPGTKRPGQTGHYRTAQYPLITLQTPNMFTTLDEMFEEGLRVSANSPCLGHRPLVSAKPLQYADHYVWQSYATVDARKRALGSGLHKLFRDGVLGGGEYETVGIWSRNTPEWQIVDFCAHAYQKVSVGLYDTLGKDALEYIINHAEISVVFVTLDHIPFLLQLGPKVPTLRMIVVMDSISPESRKILGAWGQERNIIVRDILEVEELGAQNPMDPVRATPDQLATICYTSGTTGNPKGVMLTHGNLAIAAQGHLCSQESGKYAKGRRAISYLPLAHIFERTMSLVIVAMGGAIGFSTGDPLRLLEDVQVLKPHFMSAVPRVLNRIYQAAMIASTAPGLKGALFNRAVSAKLERLHTTGERKHAIWDRLVFSKVAAALGGHVDLLAVGSAPISPAVMDFIRIALLCDVLEGYGMTENCGTCTHVWYADPSSSGTVGPVTPNTEIKLVDVPSMGYTAEDKPFPRGEIVMRGDHCFKRYYKDEKNTRATIDEEGWVHTGDVGLFDEHLRVKIIDRVKNIMKLAQGEYVALENIENVYSSCPLVAQLFVHGDSLQSYLVAVVVPDPAQLSFLVSRLLGRRIDPEDISALATAVDDPRVQSAILSEMTEEARTNKLKGFEMIKRIHATLDAFTVDNGCLTPTLKVRRPQTYEKFKDVLDALYELPELSSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJV9</accession>
    <name>A0A401GJV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SCP_0408420</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613371.1">
        <property type="nucleotide sequence ID" value="XM_027757570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJV9"/>
    <dbReference type="FunCoup" id="A0A401GJV9">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJV9"/>
    <dbReference type="GeneID" id="38779375"/>
    <dbReference type="InParanoid" id="A0A401GJV9"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15 21" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="709"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="127"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="424"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="738"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="582"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GBE82458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="985" mass="108285" checksum="3CF28A71B97B2703" modified="2019-05-08" version="1">MARSISSWLAAPFRFTPVPVTVLTVAVYAAIFALVLTADKVSKVPKKMRGLNLDQAYEDLHRITTRPHPYISHANDDVRLYLLSRLEPNASKYAHVHLSDDLISNASYIAPGNYVQPYRGVYFEGTNILVKIDGTDSSLSSSDGVLFSAHYDSVSTAPGATDDGMGVVTLLSLVDYLSAPERRPRRTAIFFFNNGEEDGLHGAYAFWKHPWSNLTSSFINLEGAASGGQPLVFRSTSLAPMRSFLSHEISHPHAEVTSADAYTSGVVRSYTDYEVFERGLRGKVPGMQGIDFAFYKNRAYYHTPMDSIPGMGYREARKSLWAMMEGTRGAGLSLLNDDNTRGEDEKGVYFDLFKYKLVLFSLNSLYVTNIVFLAMGPVVILALLGWVIVASNKASSSQTEGSNMTREGWAKAKKFLTAVMGWGRFWLALAVGIIAQVGLVIGFVKINPYVVHSRPHLVLLACMTLSYLAIVLPLQILQTLLPSAPVSQKLAVSLELYFLTWIFLLVSTIAIQKRHIGGVYWVTAWNISAWIVCGISLVEGAVRELKDPETGKKAGLDLTVEDEQEEASNRRFVRGVLYEAPEPQDTDGAEASEEHGEVVDTEPTEITPLMHQHRRRSSSGREYVTVNGVVDQAALEAKYEEFGWWILQLLVSVPLTALLLFQVVLLLLHALSNTMVDGSSPWTVYEGLAACSLLIFVPIIPFAHRLHSWLTITVAVIFALSLTISWTAFPFTQERPFKVYFQQSIELEPPSTALARVYASSAIGPFPRAVTVLTGLPGFVNERVIPELPSSWGKDLSCSEDPVVRPNLLTCRWEGALLANPGGPSSSSSSSPATEDWLDLAVTRVNASAARVSLGGRNTRACRLYFDRPIAHFAVRGAADGGALLPGYAMPPEGVRELRLWSRTWDRVFEVELWWEEAEDGYGEAPFEGRAACEWAEYASGAAGGVAGAGGRIPALEEVKMFLPVWALPTKTADGLVEAWTKFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKB8</accession>
    <name>A0A401GKB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein EI24 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0409980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613526.1">
        <property type="nucleotide sequence ID" value="XM_027757725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKB8"/>
    <dbReference type="GeneID" id="38779530"/>
    <dbReference type="InParanoid" id="A0A401GKB8"/>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42644" checksum="D70922AC3278F27F" modified="2019-05-08" version="1">MSRPSRPYRPRPPSAYSPSAAPSFVSHASRPSLSRSSYPSFLSLYETARVQLACAAQGLLDAFRWDIVVRLVASDAEIRANVSKSMLLNSISLASIYVFELLLFPLARDQRKWLHRNVGWAYQVLWLLPVVGVSLYLNSTFCTLIAKRTFVLQHGSRAAAAAAATYTGMLNALATSAYGAIMVVTSLVVSFALGYIPVLGPWLGFTFACWVDAYYCFDFVWIARGLSLSRRIRHLEERWAYYFAFGLPIAALCMWGGSLANAALFALLWPSFIIMAMHARPVPLDPFNPAWPRAHGEQEAEIRHPSPFVPIRLPIFAPVLWLNDGIARALSVGGGAGARHRRVSSDSAESVEEGAAVQMGMVGGAPVGSVRTRTRVGSGAYAPSRRKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKI2</accession>
    <name>A0A401GKI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0410600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613588.1">
        <property type="nucleotide sequence ID" value="XM_027757787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKI2"/>
    <dbReference type="STRING" id="139825.A0A401GKI2"/>
    <dbReference type="GeneID" id="38779592"/>
    <dbReference type="InParanoid" id="A0A401GKI2"/>
    <dbReference type="OrthoDB" id="2753295at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33155" checksum="08CCC4C86B55E498" modified="2019-05-08" version="1">MRYPSGSLRIQPDHLNLPLLQGLAALPLLVELSIDVNSMANDVVTRLGFKMLQTLRIDGEIFTTMRFLSMISSPFIHTFSVDIAVQEDAESLRSLSAMIAAKFPSLCNLQFRATGFGAEDLPLSAIIESLMSLRSLRVIDLTPLKGMSLSNQELVDMASAWPDAEVLSIWGTATSVDAGHVLTAFARLCPNLKDFSLPYLNFDALPSPDSLSNISAVGHCLRTLRFNALLNDSVPDPSAAAHFLDVIFPELDLKRAIAYEVDVKRDFRSPDESRWKKVLELLASLRRDREHRLDQVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL67</accession>
    <name>A0A401GL67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0413040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613830.1">
        <property type="nucleotide sequence ID" value="XM_027758029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL67"/>
    <dbReference type="GeneID" id="38779834"/>
    <dbReference type="InParanoid" id="A0A401GL67"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="12425" checksum="060B1643EF05DC03" modified="2019-05-08" version="1">MYGKFILTSVDDFIRNFVAEPSNAIPRPDPALWLAAFTGMPRNNTKENAFYAPLANCVNGRNLCPGYTLKLVYDRPDLDDPSKQKVDAALFSDSDVLDDGRPQWPVQEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLG2</accession>
    <name>A0A401GLG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0500350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613905.1">
        <property type="nucleotide sequence ID" value="XM_027758104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLG2"/>
    <dbReference type="STRING" id="139825.A0A401GLG2"/>
    <dbReference type="GeneID" id="38779909"/>
    <dbReference type="InParanoid" id="A0A401GLG2"/>
    <dbReference type="OrthoDB" id="3263231at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="466" mass="49441" checksum="CA6FF1BE6B828EA6" modified="2019-05-08" version="1">MSSSSGALSGLRSDYFMAQPRALSAHCAPPSLLELSCFSTCDYVLSELRVVCGADLGAVVDVQPIQLIINVYLLLPPGVFQFEYPIINSLINSLINSSDLNPVSTTVVNSNVDTLVYTNLHSVKYSYKHPNLGQLHCHKFSALKLQFQFCSDLGYLFGVVVALIFLLFLVDQPFDLPADKHDCGSIITSTVVQSFTITPSAGSNTSSHSTSHTGAIVGGVVGGVVGAIILVTLLWFICRRRRAKRDDFDGNFDPDRVVGGSARDGATLPAIDLAGADEVTPYSYSPAQQEMRQQADVPAFLAAGAAGAMSDRRSPPATSAPSQYSQSSDQGQGAYNVGAIPTGEFRHPSPGPSLAMTSSTHTGSTPPFGGVLQSAKEREAYRSGLQVSNPPEVVQHRDAGRLNATPEEEEAPAEIPPRCGLVDERSDCTLHLPPSLCRGLLGGFAMSFPSFTLASAVMDSPTSITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLM7</accession>
    <name>A0A401GLM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil-regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0501480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614014.1">
        <property type="nucleotide sequence ID" value="XM_027758213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLM7"/>
    <dbReference type="STRING" id="139825.A0A401GLM7"/>
    <dbReference type="GeneID" id="38780018"/>
    <dbReference type="InParanoid" id="A0A401GLM7"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="6">
        <location>
            <begin position="179"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="368" mass="40855" checksum="3FE1812BAF32205F" modified="2019-05-08" version="1">MGTLSPTHKPDYSKTEPAVPIPPQPAWSDPTKIVSFDPWGHLVPQVFKHEIKELGLDVRPSIAVTRAHMKMSEIDETARKGDLAVDGKILIKSRPLLNADGSESTAEPGVEIVISKAAVEPVWYLPGVAERFGISESLLRRALFEDTGGMYPELITRPDIKVFLPPIGNLTAYIFGNPAYLSDESKELTLRVHDECNGSDVFGSDICTCKPYLTYAIEECIRGAQRGGVGLVVYFRKEGRALGEVTKYLVYNLRKRGGDSADKYFKATELVAGVKDMRFQALMPDVLHWLGIKKIDRMVSMSDMKYNAIVQSGIPILHRYDIPAYLVPPDSRVEIDAKIAAGYFTSGKQITEADLVKTVGRTWEETEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLP0</accession>
    <name>A0A401GLP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614009.1">
        <property type="nucleotide sequence ID" value="XM_027758208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLP0"/>
    <dbReference type="STRING" id="139825.A0A401GLP0"/>
    <dbReference type="GeneID" id="38780013"/>
    <dbReference type="InParanoid" id="A0A401GLP0"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="514" mass="56746" checksum="2A0A4BC82A1E5341" modified="2019-05-08" version="1">MWCDRDPYACGVLAATSRSAPSAISPAVQYLSDPHTGARSQVLVGERVTYVHIFLSLNGHLAVVRWSSSFWQLRRERHGVSRRDMHAALAARSGSPTRSWKTRLPPSARSSPRSRPSRLPPLFPARFPTRFSVSLAKQGHPPARRDAQVRPEGLTAGESILQNKKEQCRAKIPGLRRIHACGQGQSLKATSTRPPAVEPRPRGNNDGAAGEGVLLALQGMDMAPFDSGPRRARMPREADTIFEEGFLVQPPGIDPETGERWKPRWVAKRDCGSDALSWWEANKAGLREFEVARPEVKKKEEEYDYLGEAIIPIAAFAAGSPWLAAKPEVKEVVDVSGTRPESMLDIDSFAVADPGPVRSRSPRPFVLDEGWLLSDGICSARGMYVRIGNSWADRSTPGFWRGRLEGARGAVLAVYRSHATTRVSMLSPREPSETFLVIPLKYLWPVSPDEAGQRIMVMSEGGRLGRHGARFVRPGSSPKTATIDLPRLRSEICMRLLDMFLIQSGLCEESPVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMX2</accession>
    <name>A0A401GMX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0505840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614443.1">
        <property type="nucleotide sequence ID" value="XM_027758642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMX2"/>
    <dbReference type="GeneID" id="38780447"/>
    <dbReference type="InParanoid" id="A0A401GMX2"/>
    <dbReference type="OrthoDB" id="2755889at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="621" mass="67804" checksum="C0C28A6631C323A4" modified="2019-05-08" version="1">MVDDAKNPLRTAVARDIVDAILKMTADKHNTAVYWNQSEQEQRLEVAYQKWADHGGVWTVAATKVHLDQLSHVRKGCLTCPRQDIRADGSHIEGSHKGWNSLQRSQASGIVVFSELCHDFVLRRNIQVSFKSASSSPFLRATLGSHHIHLVNSIATFWNSLLTENKQASGTASNLRRIPELQIVASGETFGLVNTKSAANYHNLLELKNEPEEELYDLSAQAELNVEEMLQQIDVNPELLRQALASGSKTHLTATATGSKSQLSTWSDTSDLKQSDVACVRGATTYSLASMSDPSTSTAVVLATPISCTPPSDVIDVDSELHVRKQKAKRLTFNVESEEGSPSVPKNAPVPMVGSSSQAGKRKVVVDGPNEDKRAQSYSGRSLQDAHALEYISAGSKRVKLSVEGWKSASLAVHNPRVESGKTASPSGGGTSTSTNGVSAGIADFFSSTRRMTAGAASSKNPGETTAAAPCTRLEFALPLLNISGLTASQRLFSISTGVHALSLTISTDNEFYLFMDLRSEQRWVSYDMTPWKWVTAANDYNLRLEALNWSKAKSTIRKTPRALMEKLGEIEPKLLAHLASGKFTSKHTNNESFWKRHCNAVPMILRDENGKTKKACTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNL3</accession>
    <name>A0A401GNL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable eukaryotic translation initiation factor 2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0503820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614247.1">
        <property type="nucleotide sequence ID" value="XM_027758446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNL3"/>
    <dbReference type="FunCoup" id="A0A401GNL3">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNL3"/>
    <dbReference type="GeneID" id="38780251"/>
    <dbReference type="InParanoid" id="A0A401GNL3"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="227"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="359" mass="39861" checksum="AA26F6C07A29A91F" modified="2019-05-08" version="1">MASEGPLFDPSLKKRKKKQVAFSEDPLGADADPTTPAPAVIDNTTTNGDAVDMGPTTVHEQMMQNGISGADAEGVDKKEEDEDFKAMFGDLKKKKKKKEIPLDLPEEGDGAATPPAASEDLDFSDLKKKKKSTKKKAVLDMEAFEKELNESKAKEAEEDEGGEEVLAEVDETELGEDPFTRSETASSLDAGNEPWLNSDRDYTYQELLQRFYVQLHASNPALLNATGKRYTIAPPQIMREGNKKSIFANVSDICKRMHRQPEHVIQYMFAEMGTTGSVDGSGRLVIKGKFQQKQIEHVLRRYIVEYVTCKTCKSPDTLLTKENRIFFMSCESCGSRRSVATIKTGFQAQVGKRSKNKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP21</accession>
    <name>A0A401GP21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0510500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614904.1">
        <property type="nucleotide sequence ID" value="XM_027759103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP21"/>
    <dbReference type="GeneID" id="38780908"/>
    <dbReference type="InParanoid" id="A0A401GP21"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="72" mass="8124" checksum="B302609858B25919" modified="2019-05-08" version="1">MGECHTWLPEPRSRPYEVNGLYPKSTEEHEVDEDADVCKSAYELKDTTEEGGSDAESLLMRHLLLRPIGPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP82</accession>
    <name>A0A401GP82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614964.1">
        <property type="nucleotide sequence ID" value="XM_027759163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP82"/>
    <dbReference type="STRING" id="139825.A0A401GP82"/>
    <dbReference type="GeneID" id="38780968"/>
    <dbReference type="InParanoid" id="A0A401GP82"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="169" mass="19983" checksum="5F3282B511D87391" modified="2019-05-08" version="1">MKNHEIMVENRLHSTQHLNEMSEGLATHTIFYVWVRYNALRRSSTKELASRYKCTLQDSEIATEKIKNNFDVTGEELERFKRENLTVRPCRVVHVGGRNPGNIQKQEDDVRARMSNMSDTYRRMVTQTQTIRQEYFNFRLPRILRALKRVRGRDRFRNAVPSLSVSVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPE1</accession>
    <name>A0A401GPE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615000.1">
        <property type="nucleotide sequence ID" value="XM_027759199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPE1"/>
    <dbReference type="GeneID" id="38781004"/>
    <dbReference type="InParanoid" id="A0A401GPE1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="117" mass="12901" checksum="1B7D8EFF35B2579E" modified="2019-05-08" version="1">MYKRYAIIAAFKGADDVECAMSAMRPVSEYFGEEPEEGVVHVVVEVIHRDFGACIPKDWHTDVSAAGQNADTVAAHGIRASGTLGSAPTGERKIPMKWYELEYLPSSDIRELRTTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ84</accession>
    <name>A0A401GQ84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0603410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615275.1">
        <property type="nucleotide sequence ID" value="XM_027759474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ84"/>
    <dbReference type="GeneID" id="38781279"/>
    <dbReference type="InParanoid" id="A0A401GQ84"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="695"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="830"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="935"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="332"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="876"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE84362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1033" mass="111510" checksum="5063D5D27D566E10" modified="2019-05-08" version="1">MLSPSPSSSAVTIPTPGKSILKRPPPPQQPFFSLARLSKLLPTQQQTSTSNDEATALKRAHFILPEMTTVYPISAANPPSTPTLKEEKRSIEEREAERRRRIVRGSPSGPDANSSEDWWSLDKVESFYRECCAGREEKPDAGISAAFKQHAAGSHPRTVDLSGVQLTVGSASVLSDVFTIEWGLRKLVFKECDLDEHVLKPMLHALLIPDSLTFLSVASNRRLKASAFRLIGAYVLKTRCLQFLDLSQNTLDKRSVEYIAAALPVAPNPGLVSLRLDDCSLKPAALDALANVVRKSSLRNISLRHNRINATGAVALALMIRDYPDRIPTTNGNSGPSSPITISPNSSSIFLSPPQTPSSPQVSLPNPDRTVTPPLRTGPVLPPPRHPSTAPQTTYTPYVPRARRAPTAPSHLSYPNPLSPNGQQVPIIATSAQGGVTARYPISPNSSTISIVNGSAMPQHYDHGPSAALLDKVRALDTLPRLGALRTLDLRGNDIRNGIAYIAQVLKRNRTLKVLNLSENKLDIQGLISIAEALKYNSCLETLDLSKNPCCGPGLEGIQSLRTAFTLNDALKRLFLSSTNMTSAGAIALAEFLPESTSLLHLDLTLNNLDLAGVMALSSGLKANHTMRCLDLNIPPADEEMARMCRDILNSCVRNTEEAEKIHQAANTDGSSGRGQAKGLWGMIEESELAKLIRQDDKKKVDEHVEASPVSARDPTDLTSTEQTQSDLVARARSCKSQLEEVLARSPSSSSTSVASIPDDLPYLTDRAREVQRLLVATIEVTTEATRLEELLVLNDELSGLLKRCLTQPSTLSLRGLGIHIDTTARNGVGAGLNGSGHATGGPEDGKGRAQPEPEEPEKVLTPTFLISESDDEEGEGHHILRADTEDALSPTDLSRSWVEEEGEVFRKGTVLLGPEEMEGEYDGEELRRELLEAMVERPPPRAVVDDFGTEIPPEPTPLPASPQDGKSFDLKLPPRPYIRRSRSSSSTTNSGDASPTAENSPISPGGTSPAVASAQKRSLLGRTLSSSPKDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQL4</accession>
    <name>A0A401GQL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium permeable stress-gated cation channel 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0604960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615430.1">
        <property type="nucleotide sequence ID" value="XM_027759629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQL4"/>
    <dbReference type="FunCoup" id="A0A401GQL4">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQL4"/>
    <dbReference type="GeneID" id="38781434"/>
    <dbReference type="InParanoid" id="A0A401GQL4"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="681"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="706"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="41"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="226"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="425"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="941"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="861"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="958"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE84517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1000" mass="113525" checksum="420730352594CA09" modified="2019-05-08" version="1">MSWNTIPQFLSFVANLDPDDDEPTGPPPGSPPTLKYEGPWFITQIIFSTTIGLLSFLIFSYSRTRWPLVFAPRTKLTGFSPHEAHAHQAFFGWILPTIRTSEFTVLQIVGLDAAVLLNFFKMSFYFFSVCSVFAVLVLMPINLKNNIDIGDGHDDEDGWNSASPLDPQPPHDWLDLISDANSYLSVHLLFTYLFTIFALYFVYQNYKRFIRARQLFSLELVHSIPARTVMVTHIPPHLRGERTLAEYFENMGLTVEGVTICREVGSLKKLLDLRTAALFRLEAAWVKYVGNPCVAELGRPAEEDTGRLVDVDDASVEAQPEQLVVPSRKRPTLRVGWFKRRVDAIDHLETQFKAADDMVQKRRRTGKFKATHVAFVTFEKMSSAQIAAQTAHAPNRSECITHFAPEPRDIVWSNISHSPTSLRVRDWIVRGSMGLLLFFWVIPITGLASLMSYKEIKKAMPWLGQLIDANQQIRAIVQNSLPSVAMIMLNALLPFLLEALTYVQGFPARSLVEYSLLKKYFLFLLINVVFIFLLASTYWQLVRDLASSPAKGIEKLADALAAGQARHFFLSYVILQGLGIMPLQLLNLGVLVPRVLYRLLITRTPRDFAELNAPPTINYGVVYPQAILIFVITLLYSVIQPLILVFGAFYFGVAYVVYKYKLLFVFYKPYESQGQAWPITFARLIWGVVIFIVFMTGIFILKKSFVLATLLAPLLAGTLLWSWNTYKIFRPLSKYVSLSSVFEVQRGEDSAEVVRLRAGHPVSWSQSNLNRRRYAQNEEILYVAPEDDRTDYSQPPMANWYSGVLNTGKRRYGHPAVNGVLPFPWLPMRHGQKVADGSRTASDNPSVAVVLTLRRKFSVLRKDDPQTDRRNDPINRSAGDAGEGVLQYGQQTSVDEMTQNPWLEREQRRYPVRTPAMTRRLSFDQGSGVIVLPEGEDWLEEDATDSDEDHGLPAVLADSQQSHPSRQASDDQQSATLPARRYSTYYHHPERRRQTYARVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQN0</accession>
    <name>A0A401GQN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0605050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615439.1">
        <property type="nucleotide sequence ID" value="XM_027759638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQN0"/>
    <dbReference type="GeneID" id="38781443"/>
    <dbReference type="InParanoid" id="A0A401GQN0"/>
    <dbReference type="OrthoDB" id="2803586at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="730" mass="80629" checksum="60F298F8DA343C99" modified="2019-05-08" version="1">MTADKHNRAIYWSREHQQRRLIDAYERWDKHGGVWNAAAAKTHEEQLGHVQKGCLARAHQNVASDGSQIEGSHKGWNNLQRLHASGLEVLLTALGHDHVLRWNIHIVSDCQRDPLDPFLSSTHRSHHIRLVDSVAKLWNTLLEDEAVKKLRGLRCLPEMQAIDSGEVFGLIQAQYATTYHNLTCSSIKAEPDEELLDLSLQDEVQACSILEDLSIDPVLYPQLANDSPVDAAAPPFTSESHTDNPLLTQSSPLSPALATGPVASVSKQLAPISSLSSMPLVIDLSSDESDTATIRHSSKMESAVQELQDQDVREGVSERWKGKAKDVEGPPSTAPVPPTSRSMQLKKVDDIQDVECGKFLPGVALKRKATSDMMPQQADTAGHGSKKVRVLESMQAVPGVAVSIAESTTHMNKSKSTTEKKKKASATVHPFFVAQRSAGNNKPARRCAESMSAGTSESALILAQVLPPLQIDGLTRSQRIFSISTEINAASLSISTDAEFYLFMDMWAEHKWASFNMSPSKWVAAAEAFNACREVLNGPRGLPMIRKTPRALMDKLGELKLKVLSRINSKNYTCSHENHNKSYCADGVMQKPKKVERHVNGQAPEMFMEDPPEFPQPRDIFTTGMHFHLDIFLKTIKHMYQQLIVQKGSGGDLSMEYIAFAGLLSKRLKVHEDGMALFELYGSLETASASRWVNSIIERNGIKYLRVDYLRDNAEAAGSLVVASAGREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQQ4</accession>
    <name>A0A401GQQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0605210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615455.1">
        <property type="nucleotide sequence ID" value="XM_027759654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQQ4"/>
    <dbReference type="FunCoup" id="A0A401GQQ4">
        <property type="interactions" value="836"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQQ4"/>
    <dbReference type="GeneID" id="38781459"/>
    <dbReference type="InParanoid" id="A0A401GQQ4"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="34"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="543" mass="59211" checksum="7341FA59CD891870" modified="2019-05-08" version="1">MSTKESQTIEQATSTVGHTALPVEGQPNSKTRRYDRQLRLWAASGQSALESSRILVISASATSTAILKNLVLPGVGHFALLDPAVVSRADAGNNFFLNGPASIGRSRAEEAVTLLRELNDSVSAEAITKDINMLLATDDGRDWVRNFSLVITHNLPNDTLDTLSRLLWDDPTGPQLIAVRSAGFLAEFYIQFREHCVSQPHTDETAPSLRITRPFPALLQWARDLDLSALDPTTHAHIPFVVILVHAVDAWRAEHGGVLPSTYAEKEHFKETLHARKMKLDEENFDEAEAQAYRVWGEPAVPPAVASLLASVSTTSAATSPLNVGFHALLGTLDAFVKDPRGPGCLPLSSALPDMKTDTTSYVRLQSLYRDWARIEKARFTEILKEKFPEIAPDVDSEELDTFVKNAHHIRVLRGRRWGTWDEERKFTSSLESSPRETATHLSLAALSTLLSQDPDPLSVTAEGLTKEVQALVGAGVDLPKEVEDAVGELARAPTADLPNTAAFVGGLVAQEAIKLITRQYVPTNGYCVVDLVDSWTGVVGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQR4</accession>
    <name>A0A401GQR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0605700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615504.1">
        <property type="nucleotide sequence ID" value="XM_027759703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQR4"/>
    <dbReference type="STRING" id="139825.A0A401GQR4"/>
    <dbReference type="GeneID" id="38781508"/>
    <dbReference type="InParanoid" id="A0A401GQR4"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="588"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1080" mass="116566" checksum="B0A6381BE3BD269E" modified="2019-05-08" version="1">MSQSSFLPPLDGSISVVPGCLDFQVEHNPDHPCFIFPDPECASVSFKDFAHATHRVAHILRPNHAGPDRAVVALIIHCDTLLYEAVMVGLIRASLVPFPMSPRNSAAAIVKMLKGTDCHRIVHHAPFISLTDAVRAALPETYNLQFDVLPNLSDIFPSFASPSAGLFSSPEPYSTCTDTPISRPHEPVLYLHSSGSTGFPKPIPQSQLSVLHWASAPYSVETRARGLRWASPALPPFHTMGVCMQLYAPLASGQPVALYTPRSHLNLPPPVPTTQNVLDVVRRTKSSSIVPVPSFLEEWAQNEEDVKLLASLEVVCFAGGPLSNHNGDKLIAAGVKLFAAYGGTEFGPTTRFLDTIEDSPNHPDTVKTGKTRNEWSWMAFPSEYNLRWVPQGDGSYELIFMTCATHQPSIENMSGGERGYATGDIWEPHPTKPGLWRITGRADDLIVLGNGEKFVPVAQEGHIMAHPKVMGAMIFGRGRTQAGIIVEPRGFAVSPGDEDALSKFRNVVWSQVEEANHAAPPFAKIFKETIIFTDPDRPFPRAAKGTVQRKQALTLYEAEIEQLYKTIEDSSDAHGIVPPSHWTVPVVQAWMVEHVSQLSGGIAPTPTTDLFEHGFDSLSATFLRNRIIGALRSSHEPAANAAALHVHSNFVFNHPSLVELSAAVVALVHPSHDNASTSTADESAADIEALIAKYTAVLPEPTPAGAKRERGKVVLITGTTGALGAHILALVLANPALQHVYALNRGIGVAERQRAAFEAALLPVKLLSDSKLTLLEGNIMREDLGLESAMLDEVRSSVTDIVHNAWRVDFNLSLSSFQGHIAASVRLATFVPGARFFFTSSITVAQSWKALKSSRVPEEPLGDPAVAVGIGYGSSKFVVEEVLENARKVGFPTTSLRIGQICGSADTGAWNTSEWVPSLVKSSISLGCLPRMPGVVDWIPMDSVAQATVDVVLSVSAPAVVNLVHPRPVEASSVFDNLNEELGLQLPFVPLSDWVQKLENAAQNASAKDLEIMPAIKLLEFFRSLAAGQASKASSLGADDPVFDTSKAQSASATMARLGALGKAEVHAWVKFWKGQNFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQW4</accession>
    <name>A0A401GQW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="5">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0605950</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027759728.1"/>
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    <dbReference type="OrthoDB" id="409122at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Tripeptidyl peptidase A"/>
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        <property type="entry name" value="Peptidase S8/S53 domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00082">
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    </dbReference>
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        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
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    </dbReference>
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        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 16" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0843">Virulence</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
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    <feature type="chain" id="PRO_5019137280" description="tripeptidyl-peptidase II" evidence="18">
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            <begin position="19"/>
            <end position="568"/>
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            <end position="285"/>
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            <begin position="266"/>
            <end position="280"/>
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    <feature type="active site" description="Charge relay system" evidence="16">
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        </location>
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    <feature type="active site" description="Charge relay system" evidence="16">
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        </location>
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    <feature type="active site" description="Charge relay system" evidence="16">
        <location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="GBE84616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="568" mass="58717" checksum="1753C8BEC278FD60" modified="2019-05-08" version="1">MVFASALLVAFLAVLAAGNPMSRNMKPHEKRDGVPTGFALVGPAPPDTVLDLRLALVQSNPAGLEQALYDVSTPSSANYRKYLTKEEAAGFVSPAAESLAAVNNWLQANNIDATVLTPAGDWISFSIPVSQANDLFDSEFSTFVHSTSGQQSIRTLAYSIPVELQGHLDFVHPTITFPIYLASSSPYSVSTKSTRATVHERQDPSCADTVTPACLQALYGIPSTPATAQSNQLAVTGFNNKYANLADLASFLEQYRPDMSSTTAFSLQTLDGGSNDQTPGSAGDEADLDIQYTVGLATDVPITFLSVGSQNNDGVAGSLDVVNYFLSADAPPQVVTTSYGMDERSVTPDLATNLCNAYMQLGARGVSLLFSSGDGGVAGATFGGEDCDGSNFIPTFPASCPYITSVGATQGFGPETAAPYSSGGFSNNFPAPSYQTTATAGYVQGLGSTYSGLYNPQGRGYPDVSAQGTNFQIVLNGENAGEEGTSAASPTFASVIALLNNELALAGHPPLGFLNPWLYGSAASALNAVTSGSNPGCGTNGFSAAAGWNPATGLGTPDYAKLRTAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR12</accession>
    <name>A0A401GR12_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0606560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027759789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR12"/>
    <dbReference type="GeneID" id="38781594"/>
    <dbReference type="InParanoid" id="A0A401GR12"/>
    <dbReference type="OrthoDB" id="2811554at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="154" mass="17841" checksum="D8F7497DFF513348" modified="2019-05-08" version="1">MSSLREIHPGFQPGVSFALARQVPAYEELPPVLKPTAFGPIPPIMHYGYLITFEQFFAIAAMQLGFSIELKDHAWSEDIAMHKVAQYIAGKVIHHPTKVAWVCVDRKRPFLLSLCTNWYPSQRLEEVDPKVREYLGIEEKGKWYLDAKQWQWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRF9</accession>
    <name>A0A401GRF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615731.1">
        <property type="nucleotide sequence ID" value="XM_027759930.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="38781735"/>
    <dbReference type="InParanoid" id="A0A401GRF9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="474"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="474" mass="50704" checksum="78285BB75C42B584" modified="2019-05-08" version="1">MNDGNSVATPASTLCLALLQAVECKRWAACLFSKVEGHASLIVVAPATAVPQRRAAPSSRSPQLLEASPHPTPLPRSLLRPSSTCSDRPRPSNANVRRRVCFRRTRGSPAASLSYRPPRCNSGAQRRLRGHPGPAMPHSTSLCLPSTLLDPRRPTTMNDGAPVVTPASALRLALPQAVERKRSAARLFSEVKGQLSHAVVASATAVQLRPAAPSPRSRRPLKAYLHLPAPSLGPLRPAQAHGGERRRRGGRVGHRGATKARSPNYSVAKASRGPRQPLSTSPHPLSGVFDPRWPTAANDGHAVRRRPRHKSAKAPGSLSRPPRTLSRASSTRAGPRRRTTATRCDDGPATSLPRPGRPLHLPAPPSVPFDPRRPTAANDGGAVVVSATTVQRRRHHRVSVATPRPPPQPEARGPLCHRTEMLDPASIQEGSRGPSVVVIAPATTVQQRHAAPSSRLPRPREAPRSPTTPSRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRI7</accession>
    <name>A0A401GRI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615736.1">
        <property type="nucleotide sequence ID" value="XM_027759935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRI7"/>
    <dbReference type="GeneID" id="38781740"/>
    <dbReference type="InParanoid" id="A0A401GRI7"/>
    <dbReference type="OrthoDB" id="3257564at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="38515" checksum="A2791625A77182FE" modified="2019-05-08" version="1">MVSYDSPPPPISKKRRQEDDAGDLAGQHSADDGAIAGSKLAAGGPAPAVASTYVHYEPPRAPALMPEVSGLLTMSREGFVYPPTSSYGLASAREPAWQPPMNPPAAVAAAGSLRHSLARLELKSHDTRVKKVQLDQDDNQTSSSYDCHVKNYATYWATFQAERCQRALGEVPVPVFPVTALKASFFLEYEIMREKCRQGKNEAITGSNMGKSHISQVINALESWHRNNAYLYKDDPDAQMSLRTDICIHTAESSAKHQEPKCIEKTQALKAAGSSGDTYTPDELKRCLIWCLMDVSGVKSIWIGLRDRAMLLLSSTMAFRGESSHILEWLDLFLSSIPMDDVKPIQPIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRL2</accession>
    <name>A0A401GRL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0607700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615703.1">
        <property type="nucleotide sequence ID" value="XM_027759902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRL2"/>
    <dbReference type="STRING" id="139825.A0A401GRL2"/>
    <dbReference type="GeneID" id="38781707"/>
    <dbReference type="InParanoid" id="A0A401GRL2"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1965" evidence="3">
        <location>
            <begin position="123"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="2">
        <location>
            <begin position="202"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="294" mass="33795" checksum="DD676907BA3EC77F" modified="2019-05-08" version="1">MIYHMDGYRPAKEDALAYLATQMRALPQTDTLEPGDGHAPADIYSRDEIPRNACGLTTLWEMQSLLAKIMPPLAEFTRELFCGVAPGLPNDTLVVGAVAPLSIDGSFHRTWVNWRWNVAGPYLHPVGLSHYIDITGTDPRNWKLLKIVYNYQVFSSTDEFLEAFHNGTLKRLPARTDQPIDVAWSRRERPDIPPTWTTCLFISWMGWEMYLGFDRDMGLSLWDIHFRDERIIYELAPQEAIAHYAGNDPMQSSTAWLDRFFGMVRSHQSSTCVVVLVVVHFQPPRLRLEMVRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRM6</accession>
    <name>A0A401GRM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0700550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615788.1">
        <property type="nucleotide sequence ID" value="XM_027759987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRM6"/>
    <dbReference type="GeneID" id="38781792"/>
    <dbReference type="InParanoid" id="A0A401GRM6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="102" mass="11419" checksum="1B7832700EE6A088" modified="2019-05-08" version="1">MVARYIKMRHHLTHADHGQHGGVSFETNGHTGHVSRCSWSKATHGKIRRISRHSPAKPCASRDTISCRSGCVLWGTTRYLDRTLRQCLRCGPWQLGHNCGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRT1</accession>
    <name>A0A401GRT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0700400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615773.1">
        <property type="nucleotide sequence ID" value="XM_027759972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRT1"/>
    <dbReference type="GeneID" id="38781777"/>
    <dbReference type="InParanoid" id="A0A401GRT1"/>
    <dbReference type="OrthoDB" id="3190888at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="168"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="315" mass="34862" checksum="2F40B402B481CEAF" modified="2019-05-08" version="1">MAFLFSKDAVLGAAFIGFSISTLCLGALSMQTYTYFRRYPQDRPFYKALVAFIWILEFVDQAVVAHAVYFYLVTNWGEPLSLLGRPVWSLLVQVTLGAAAGTVVKACFAMRVWRFSNRNIWATGLILLLTFAQMATACVFTRKGFEMSSLADASQLRFVATLSLGIGVATDSVTAIALCIFLRKLRTGYTKDDSIVNRLSLFAVNTGALTSAFSLATLVTYDTMPSNFVYMGCYFVVSKLYANSFLATLNTRKVLRGRGTDGEHVTMPTFLMVGKITEQDQEDQDITTQGSRIEVGVQREISLSRDPIPSYAVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS64</accession>
    <name>A0A401GS64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0702540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615981.1">
        <property type="nucleotide sequence ID" value="XM_027760180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS64"/>
    <dbReference type="FunCoup" id="A0A401GS64">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS64"/>
    <dbReference type="GeneID" id="38781985"/>
    <dbReference type="InParanoid" id="A0A401GS64"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="238"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE85068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="458" mass="50841" checksum="06071D3EDB29DCE8" modified="2019-05-08" version="1">MSSAQPPPPPPDNNNEKQPETEPSTSTAPQEAAMDTTPDQPAEETWADIPEDIMNLSTDEILTRIRLIDNDLKVMRSETLRLQHEQNVMKEKIRENGEKIKQNKVLPYLVGNVIEILDVDPEGEEDGANRDLDSMRKGKCAVIKTSTRQTVFLPLIGLVPAEKLRPQDLVGVNKDSYLILDTLPAEYDSRVKAMEVDERPTETYTDIGGLEKQIEELVEAIVLPMEQGDKFKTLGIVPPKGCLMYGAPGTGKTLMARACAAQTNACYLKLAGPSLVQMFIGDGAKLVRDAFELAKEKAPSIIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLDGFSSDERIKVIAATNRIDILDPALLRSGRLDRKIEFPLPNETARARILEIHSRKMAVSPGVNFEELARSTDEFNGAQLKAVCVEAGMIALREGATKLNHEHFLSGIAEVQSKKKNDLVYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS92</accession>
    <name>A0A401GS92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0702730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616000.1">
        <property type="nucleotide sequence ID" value="XM_027760199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS92"/>
    <dbReference type="GeneID" id="38782004"/>
    <dbReference type="InParanoid" id="A0A401GS92"/>
    <dbReference type="OrthoDB" id="2984821at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="164" mass="17836" checksum="D0DEA5BB3187AF73" modified="2019-05-08" version="1">MPTSLELAISSVISSQKSLSVPNVLAAYLHTTGFLPEPDLTHCGGAVAHEALVAFEHALDKQPAPPRSRVHAAEIDDVRKRYWLSRLGNEAPNRCTCPSCGKTVAYARAQLEDQKEQEASGEKPKQKTRDGRKKKKRVVKRRTGSSDSSSSYNPYGASSSTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSC4</accession>
    <name>A0A401GSC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0702560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615983.1">
        <property type="nucleotide sequence ID" value="XM_027760182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSC4"/>
    <dbReference type="STRING" id="139825.A0A401GSC4"/>
    <dbReference type="GeneID" id="38781987"/>
    <dbReference type="InParanoid" id="A0A401GSC4"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="322" mass="35458" checksum="E2BD6441C65C3574" modified="2019-05-08" version="1">MATGLERGSAAAQPDAVIIDEGFLIQRTGVNPRTGEAWKPCWVIRRDCPSALLTQWNEKRSIVSSGEVKQEADDTPKLLLNSGIDVLRKRTASVSVKQEQEEIKVEDGGDRKRQKSERWTAPQVAAHTSSQPSKPKWGPSRSGVSSTDTDSAELPSGDASSTQLHSADSTFELAVRHENWLLFPEIRSKRGMLVVIQGSHGDGQKDGWYNGDLEGARGVILMVFVSGSSIMPPVARVKMLNPRDESEATLTIPVVYLWPVEPDEPGQNVLMLQGDHRGEVGKVREEDEIGWFISVGKMHCTVAAENLERILEVDEDDNILNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSS3</accession>
    <name>A0A401GSS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616178.1">
        <property type="nucleotide sequence ID" value="XM_027760377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSS3"/>
    <dbReference type="GeneID" id="38782182"/>
    <dbReference type="InParanoid" id="A0A401GSS3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="340" mass="37999" checksum="140BA2D0FB7945DC" modified="2019-05-08" version="1">MDDRTSRHDDYEPLDLSTEIQLPVPSSVAQPEVMSATISKAETGVQSVQLKHNLQRIFHCTDKHIWAPIIGWGSIFIAGSLCGRFFGVRPLYIARYRMRLAGTCAALGTVTFWNMAINNNVSKFVADDDIHPITNVVFTFYTVAQDPERRKALILPESLDSVIPDLFARIQGPYISPGTDFSSGLSQRITWWTSHIWPSRKAQGAARWWFQGFLEGQQLSPHDIDIIMTLVAHGIDGQSWDEMGGLAIVTTLGLAAARALARKHMRITRWLNYFLAASFGASAIMSQFRLYQLTAYPFDIHDKAGAAAALRKFDIKKADGGRYEQLLNRGAQSRAPQSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT73</accession>
    <name>A0A401GT73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0706250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616351.1">
        <property type="nucleotide sequence ID" value="XM_027760550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT73"/>
    <dbReference type="STRING" id="139825.A0A401GT73"/>
    <dbReference type="GeneID" id="38782355"/>
    <dbReference type="InParanoid" id="A0A401GT73"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="109"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="423" mass="48155" checksum="A7F7B951AD626E86" modified="2019-05-08" version="1">MDAGHAVAACHGGLGVVLPNQARILEFASNSHLQHSRLRLEAMAGRRPANAGKANANLPPYVFCSPEQAQNHAEQTRNGMYSLNTAEIFWRDRQPYLDERGYALRPRYHQNWSPSWQGTNMEPMFCEDSIRLIICVVIDAIRKSDGLSVSIKIVKRDDDEVRIASYLSRPEVSSHPLNHCVRVLDIFPDLFDQETAFLVMPYLRPFNNPDFGAIGEVTEFVRETLEGLTFLHSQHVAHRDCAAANIMMDGTPLFPQGHHPVRRQSSPDGIYLLSPLSRIDHPVRYYFIDFGISSLFKEGESPYVVGRKGRDKELPELSDDVPYNAYKVDVFILGNLFKKDFLQKYYGLEFLEPLVKAMTARDPAHRPDAEVALSIYHDIRRGLDPSLLRWRLRARDESAPERILYDSVAVAREGIYRLKHIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTR3</accession>
    <name>A0A401GTR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lactam utilization protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0801140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616509.1">
        <property type="nucleotide sequence ID" value="XM_027760708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTR3"/>
    <dbReference type="STRING" id="139825.A0A401GTR3"/>
    <dbReference type="GeneID" id="38782513"/>
    <dbReference type="InParanoid" id="A0A401GTR3"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="231" mass="24850" checksum="4982F43232BED0C9" modified="2019-05-08" version="1">MGDDDSLMKTIHLANIACGFHASDFSIMNKTVLLAKENGVLIGAHPSLPDRQGFGRREMMMEPEELASCFIYQVGALVGFLTRYGLPLNHIKPHGSVYGMTARDMPLARAAVGVAKTFGVAFMGLAGTCHQVAAKELDVPFIAEWFADLEYSPEGKLIITKKHDPVPLNAVHNRVTKLLKEGQVTTTSGFVPLSDGVTDVSICCHSDTPGAVEIAQTVKALVDESNQKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTT8</accession>
    <name>A0A401GTT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylsterol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0801110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616506.1">
        <property type="nucleotide sequence ID" value="XM_027760705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTT8"/>
    <dbReference type="FunCoup" id="A0A401GTT8">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTT8"/>
    <dbReference type="GeneID" id="38782510"/>
    <dbReference type="InParanoid" id="A0A401GTT8"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="136"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE85593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="38609" checksum="61B7193E400B80BC" modified="2019-05-08" version="1">MNSTAPSYTSAEVLYASTDFSKLNWLETQWAAWYLWIGNPVIATGLMSFLLHEIVYFGRCLPWIFIDATPYFQKWKLQPDRIPTAQEQWDCTKQVLYSHFMVELPVIWLFHPVAEMFGMSTWQVPFPSWQIMVPQVALFFVFEDMFHFFAHQALHWGPLYKHIHKIHHKYPSPFGLAAEYAHPAEVMILGAGTILGPLGYCYIKRDLHIFAVYVWITLRLFQAVDAHSGYDFPWSLQHILPFWAGAEHHDFHHMAFTNNFATSFRWCDRLFGTDIKYLEHRRRMNELKKSGLSREQFAAAEKKMLEQVEAEGVVEAAKVEAYRYGSKKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUK2</accession>
    <name>A0A401GUK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0803980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616789.1">
        <property type="nucleotide sequence ID" value="XM_027760988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUK2"/>
    <dbReference type="GeneID" id="38782793"/>
    <dbReference type="InParanoid" id="A0A401GUK2"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27032" checksum="9AAB6E7F2EA54329" modified="2019-05-08" version="1">MLILHRNVGVHSIMCEIRSDSVHAILTDFSRACHVSKTGEPLGIHEGWPSPSQDRLQSLEAQQSVVEEQSNPFHPDLSWVPGDVPHLLLYDYEGLLYTAVWCTCLPRRLRWRDRNFFPWYIIIHDVSDGRPFAERHHPLPEFRGYTKWMTAFWGLFCNARKAVNIMGRSASMHDQETAYGILTAEAIKEKLQAVPLCEEVGESKSDLLESSAQISGAPEIGERPRADKPTPGPHMYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUY0</accession>
    <name>A0A401GUY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616902.1">
        <property type="nucleotide sequence ID" value="XM_027761101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUY0"/>
    <dbReference type="STRING" id="139825.A0A401GUY0"/>
    <dbReference type="GeneID" id="38782906"/>
    <dbReference type="InParanoid" id="A0A401GUY0"/>
    <dbReference type="OrthoDB" id="2803529at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23045" checksum="A359C1660C450B44" modified="2019-05-08" version="1">MVFLDFAALLLDWHRGIHNACRSSPVPLHVHWAVHSTAHVLVTLSLGGALKLDLSHLPVSLLTASQCHAAQVTISSRIWLSTLSTVPRSRPHSNMQGYSTSKSERKYVELLYRASTKYSNWNPEVEVGDWGHITAPSSSWPFSRGRGGIFVKEGNIYEDGLAERYDVPQPAEYGGDALEGVTWLVSQNAGEPDRTHDVASSTPALASCRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVU5</accession>
    <name>A0A401GVU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617226.1">
        <property type="nucleotide sequence ID" value="XM_027761425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVU5"/>
    <dbReference type="STRING" id="139825.A0A401GVU5"/>
    <dbReference type="GeneID" id="38783230"/>
    <dbReference type="InParanoid" id="A0A401GVU5"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12208" checksum="106742341110D26A" modified="2019-05-08" version="1">MTKLFMPMTPGKWGTNIFSSEQSADEIGLVNQHGLSRKHIFDVVKASLERLWLDYIDLRQCWHCVSLSANGTSLPNIGIQAIGSTTKLPSRRRCKHYTTLSKPGTCATSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVW8</accession>
    <name>A0A401GVW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0902120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617246.1">
        <property type="nucleotide sequence ID" value="XM_027761445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVW8"/>
    <dbReference type="FunCoup" id="A0A401GVW8">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVW8"/>
    <dbReference type="GeneID" id="38783250"/>
    <dbReference type="InParanoid" id="A0A401GVW8"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG-I" evidence="3">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="767" mass="87029" checksum="3B7AC1AA5780A73E" modified="2019-05-08" version="1">MPIKHLDGYLAERKHLQTHPLSILSDSRLGIDASYYLGLLNDNPPSREPLLAATGGLPLALTVRIESDLRVLEKLHIKPVFVFPGLVPNRRLKPQHQHYEYNEACRDRREAWTKYEAGQEETATKLFEGRSNLHQWDLWKMVLRIFRHRNVEFIVAPYVGWAQLIYLQRHPKSYIHAIFGPTDTLLYPGVDKVITSLDLVSANPSFTFVSKRSILSDLSVSEDQFLDIGILLGFDHSPSFPPTVHEQALKATVDMVKYYKSGHAAVSAFSEQPQVKSIQYPDHYARTRSMIKYSLIMNSEGAVTPLPVSINTSPAHTHQNHHPHHPTVTDIPQDLHDIFTHRLPDEIYFYVSRGLMGPQSLVWLTSGQIIENPPLDNGETTEYRRFVKEVITEGQTGPRATALALISSVTNSAWSNKKVAAYFWFEQPTPQKQITHNSQQTAQLAERVVGWNVPYAIVEEELRRQNSSTIDFALCLGATVSEKLAARTKIKNGQAAISMSLEKKDELVANVIWRFLELRGFLLNTHTHSPLARAMHTAIRSARVNDKFQDSLYLFLELVRAGVMHGNLWSGRAFSGGPSFGTDDEKSCMLLVMRVLSIVPLNFKPQPWSAPLSRELLVFNSFVRSLTRALRTLLEVTSLNMLLRHDARRARDDYLDINLSLPFQSEVNTGFGVLAKVYLDALTHINNRQRVRDPNAEGVKEAKLMALEICEETFPGVKFPKLEVERGFRFWDVTLTAMRQLHSEGAVLRELIDQFEAAEAWLAPMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWK4</accession>
    <name>A0A401GWK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0904860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617520.1">
        <property type="nucleotide sequence ID" value="XM_027761719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWK4"/>
    <dbReference type="GeneID" id="38783524"/>
    <dbReference type="InParanoid" id="A0A401GWK4"/>
    <dbReference type="OrthoDB" id="3244737at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="321" mass="36598" checksum="1211806B34BB6E67" modified="2019-05-08" version="1">MSHSAKENDHQERSRRTYLRGKILHEHLEQVARRHSGPDAQRLVDGLTYASAISLLDQTPQHCTTVLANPESVEATENDEDVERCVSGGLSETDLKRFGSPSTLMTSQIQKQLLVELKRTLLTVVEFWSDEEDATEEERLQSAFELPENIRLQKERIVQQRAELKEHYVRTQNLVNDINEIHPRLEEVLINALTTLPPILNASRVAKADVLSMTIETCLLRLSLIRARAHTALYGRTSSKNPDATMSRALVVAHGKLAAKQHTQREEERVLDRQIEEYERLLSLVDGRDGGFAQVVKDRARVRSETQECKRDLRRLGWTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXB2</accession>
    <name>A0A401GXB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SCP_1001100</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617781.1">
        <property type="nucleotide sequence ID" value="XM_027761980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXB2"/>
    <dbReference type="FunCoup" id="A0A401GXB2">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXB2"/>
    <dbReference type="GeneID" id="38783785"/>
    <dbReference type="InParanoid" id="A0A401GXB2"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07541">
        <property type="entry name" value="P-type_ATPase_APLT_Neo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000085">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="957"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1009"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1035"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1063"/>
            <end position="1083"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="220"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="897"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="484"/>
        </location>
    </feature>
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        <location>
            <position position="484"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
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        <ligand>
            <name>Mg(2+)</name>
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            <position position="485"/>
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            <name>ATP</name>
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        <location>
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        <location>
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            <name>Mg(2+)</name>
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            <dbReference type="ARBA" id="ARBA00001946"/>
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            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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            <dbReference type="RuleBase" id="RU362033"/>
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    <sequence length="1131" mass="126488" checksum="5F3C60356E380019" modified="2019-05-08" version="1">MSEIPLHSLGRARKSKAGYALLNGEPTDNEQQSQDMPSGTTIAASVSSRISRKGKHRERYADQAEEEAANLLGDEFQDDDGEDEVRTPSLSEPSSQRSSLVRRGKSASNDKSRTVPFRPPDNLRTRYPPNIVRNQKYNAFTFLPIVFYEQFKFFFNLYFLLVALSQFVPALKIGFIATYIAPLAFVLCVTMGKEAYDDYQRNLRDREANSQRYLVLEHSADLHDSGPHTRSVPSSSLRVGNLVVLEKNQRVPADLVLLRTSDHSGTCFIRTDQLDGETDWKLRVAVPACQKLVSEMDLLSLDAEIYADAPIKDIHTFIGTFTINSPSTTSVNDVPMVPVPTVEPLTAENVLWANTVLAAGSAVGLVIYTGAETRAVMNTSHPETKIGLLDLEINRLAKILCAVTFALSVVLVALNGFRGQWYIYIFRFLILFSSIIPISLRVNLDMGKTVYAQQIMTDSEIPSTIVRTSTLPEELGRIEYLLSDKTGTLTQNEMEMKKLHMGTVSYGFDSMDEVAHQLSMAFGTSAEQVHNRTGTTATGIQLATRGRRDMSSRVHDVVLSLALCHNVTPVTNDDGTVTYQASSPDEVAIVKWTESVGLTLTFRDRTRIQLQTPSGARINFEVLDIFPFTSESKRMGIIVRDVQTGETTFLQKGADVVMAKIVQRNDWLEEECANMAREGLRTLVVGRRRLSDASYTHFKEKHYEASVRLEGRSEAMTAVIEELLERDLELLGLTGVEDKLQDDVKSTLELLRNAGIKIWMLTGDKIETATCIAISTKLVARNQYIHQVAKLKTSDEVRDQLEFLQNKLDCCLVIDGESLQLCLNLFKNEFIEIATKLSAVVACRCSPTQKADVARLIRRHTKKRICCIGDGGNDVSMIQAADVGVGIVGKEGKQASLAADFSVTQFSYLTKLLLWHGRNSYRRSAKLAQFVIHRGLIISVMQAVFSAIFYFAPIALYQGWLMVGYATVYTMAPVFSLVLDRDVNEDLALLYPELYKELTKGRVLSFKTFFMWLMISLYQGAAIMIMSLILFENEFLNIVSISFTALILNELIMVALEITTWHIYMIISEIVTLLLYVVSIAFLPEYFDLSFVLSLRFAWKVGVIVAISAFPLYIIKLIRSRIAPAASSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXQ7</accession>
    <name>A0A401GXQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1002290</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Also interacts with RBP1/DNA-directed RNA polymerase II largest subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617896.1">
        <property type="nucleotide sequence ID" value="XM_027762095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXQ7"/>
    <dbReference type="FunCoup" id="A0A401GXQ7">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXQ7"/>
    <dbReference type="GeneID" id="38783900"/>
    <dbReference type="InParanoid" id="A0A401GXQ7"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="34"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="15">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE86983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="153" mass="16379" checksum="8EF2AB2452F0E28F" modified="2019-05-08" version="1">MPSPTKSGGKSGGKSKSAAAAAKEAAAQEAAAPPQRTLQTRSQKAGLQFPVGRIHRYLKQRTQHNVRIGAKAAVYTSAILEYLTAEVLELAGNASKDLRVKRITPRHLQLAIRGDEELDTLVRATIAGGGVLPFIHKSLTMTGKQTKRPEGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY65</accession>
    <name>A0A401GY65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1003940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618060.1">
        <property type="nucleotide sequence ID" value="XM_027762259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY65"/>
    <dbReference type="STRING" id="139825.A0A401GY65"/>
    <dbReference type="GeneID" id="38784064"/>
    <dbReference type="InParanoid" id="A0A401GY65"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09326">
        <property type="entry name" value="LIM_CRP_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF35">
        <property type="entry name" value="MUSCLE LIM PROTEIN MLP84B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="255"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="328" mass="34884" checksum="2CE7AC16ACFE70A9" modified="2019-05-08" version="1">MHPFGGTPVCPRCNKMVYAAEQIMGPGRKLYHKPCLTCTTCGKRLDSYNLVEHDQEPYCKNCHIKNFGTRDTRLANLPNRDEVFVSSPPTLPVRGGFSPTRRVASPPPASTAPQLPVRRHVNSAPSAPPMLRPTRTFSPVRTTFSSNDPVATEETGEEDAHSEGPRTPEPASGAFPTHTGRVGGLPRTVPLTLSPSKGRNGSPAKPEDTAAGQTSPTLTRTLLPSATGTRYGVALGGRGTGVGTVSPMMTGGRGPTCGRCGKTVYFAEQVKAIGKTWHKGCLRCTECGTLLDSTRLTEREGSPFCQRCYGKLYGPQGSGYALLGKAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYA6</accession>
    <name>A0A401GYA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1000260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617697.1">
        <property type="nucleotide sequence ID" value="XM_027761896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYA6"/>
    <dbReference type="STRING" id="139825.A0A401GYA6"/>
    <dbReference type="GeneID" id="38783701"/>
    <dbReference type="InParanoid" id="A0A401GYA6"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="269" mass="28351" checksum="B9CBACB0034D66F0" modified="2019-05-08" version="1">MVTVRDAQGGVQLAPHEAHKMAVCALGVSPDGLMLLSAGDEVVLLWKLSPRLAGGAAVCGRLKGHKNFVYNCAWAPDGRRHHCADVEKGETTHLLGGHTSIINCIVFSADGQRVATAAGDYTAGVWDVASGAQLSLLQGYVGILYTVAFSPDALRVVTGAEGTVRQVLSVGAEGRVKVCDSYSGEVLRSIDATANAKDRLTIAAISHDGKLACTTARDNVVRVWNLDTGAAVAAFKPGHKDCVQVLTFSPDAKRVISSSDDETMRIWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYP5</accession>
    <name>A0A401GYP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent bile acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1005320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618197.1">
        <property type="nucleotide sequence ID" value="XM_027762396.1"/>
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    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
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    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="173"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1101"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1189"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1286"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="297"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="708"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1385"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="946"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="946"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE87284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1920" mass="214620" checksum="DDD2F613EF7B141E" modified="2019-05-08" version="1">MKVCSGGARELYALASPCSREFWSAVLPAGFVAFVLLSLVPIPTLLRSTVNAIKRPFTEFMSLPEAEALDAGEDVSEEEILKEASPAPLWRGVLLAFVAVVETLVWLGICARAMYLEPEERWKAMYAFLVAFSWFYAAGRPVVAPTATVPSDLFILFFMRFVLSLLMFGGVLFDHAVYGFPLPSPLALAAYIADLVAAALLLLVVVNMPLAIPSRRVNKAEIGKSVSPEDYTTLWGWASFMWVMPLIDRGTVTTLSEDDVWALSPTMQARPLYIKFMRSKSLSLLRRLWSTNSKDIILDAVLAIVSIVFNYAGPFFLKRILDALDSRSDPTSEMHAIACVFAFLAFLSTLCKAESDVQHLWYSRHASIRARSELMTAIYDKALKRKDFSGIIDKEKMKEAKEAKDAKGKAPEPAKPAEKKDPNVDDPKAGADIGKIVNLMAGDAGRIANVISSMYMINGAPFEIVVASTFLYQLMGLSAFAGFIILVVGWPLNNHVAKRAVRIQKGVSTARDKRMSVLNELIGAVKFIKFFAWEERWTERVMDAREVEMQWMVKSRVNNVMFSLIWTTAPILLSVTSFTVYVLQGNELTVGTAFAAITLFSMIRVPLNTIPAWIVQALEAKVALDRIATYLGEEEVDEQVSSLKRKYVKPTDVEEEGFGIVNGAFKWNEVKEKDECKDKNGKQKRRSPFDSGSDETNTVVEGQSSAGDTEGDLAVDMNHRFELRDINVMFPEGELSVVTGPTGSGKTALLMALLGELTRLEGRIVMSKNPSKVDEHGLSHTISYSAQSPWLRHQSIKNNIIFGFPYDEERYNAVIECCALQTDLSILEDGDATEIGARGVSLSGGQKARVALARAVYARSKYVLLDDPLSAVDSHTARFLVERLLCGPLLEHRTVILVTHHVELVLPGAHYLVRMLDGRIDMQGMIKDLRAQGILDYITHDESVEAHKEEQQVQEEENKGNPNAEIDAEGSPETAVEAAKPKSARKLVEEEKRETGSVKWSIYNTYLKASSYWTWIILFTLVVATQFLGVSGKLWIKVWGEAYGAPNSTSMYMYKPWATSHHDVLMDESYHNLQLVQNAVAPSVPGKFLGINWPPAQQHPFFYVGIYLAITLSTGLVNITAVITQYTGALRASRVLFGQMLRTVVRAPMRWHDVTPQGRKLNRFSKDIETVDSSLASSLQAVNTSLASFAASVITVVVVFPLFIIPASILSFFYRRAVIGYLHTGRDLRRMESVTRSPIFANFNELLEGIVTVRAFSAEQHFLEDLYTKVDLTTKMWYSFWMTNRWLSLYFDLLNACAVLATTLFALAGYVEAGIAGVSITSAMSFTTSVYWACRFWTSLELDLNSVERVVEYLDLPQEPPAVIESNRPPAYWPSSSSPNKDSMIAVEDLVIKYSPELPAILHGVSFTLKAKERIGLLGRTGSGKSTLAMSILRFVDPSSGRILIDGVDISSIGLHDLRSRITFIPQDATLFSGTLRDNLDPFGEHEDSECLDVLYRVQMLTDSQLESQKSSREPSRPASIIEREGTIASVSMSATETEGKTVITLDTQVSAGGTNFSQGQRQLIAMARALLRRSSIIVLDEATSSIDFATDAKIQATIREEFNDSLLLTVAHRLRTVIDYDRLLILDKGELVEFDTPLNLIQKENGIFRNMCLKSGTFAELEAAAKAKAERDLLFPVWQLSKYLRTTTLKFMIVQGLRDLVFWHGYSPRTLFNSRRFHPNRHNTIARLPSRNVEVYTSENSVIAGFWQYGRVTWVTFFAWLTNVLCVPVDWAIFEYDVETRRVGEEKRSGDTIVQPGHYVLLTIDGRPTRVFVASERARPRIPTHSETPARDNHYRLRSRARDGKCLITGLEANTYSRLKAAHIFPTESRSYLPASAFDGVATKGLCQHDYRYSGRSVPRRILQDRFCAEYHYIAERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYV6</accession>
    <name>A0A401GYV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027762452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYV6"/>
    <dbReference type="GeneID" id="38784257"/>
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    <dbReference type="OrthoDB" id="2536714at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
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            <begin position="133"/>
            <end position="200"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
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        <location>
            <begin position="421"/>
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        <location>
            <begin position="463"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="537" mass="58327" checksum="0B5C14BA20F2F493" modified="2019-05-08" version="1">MRQAKRTSSPTVSLSHETSPSGEPPSTPSPRGRPASRYPSSLALGEPGRVPLHRRGTSKTYERLEDLLREAGYKETRIFTPEAERAEEGRRGSVRGGVDAVVGFLAGWIPGAGKGEDSPGEDAVVAGNSEIGEPVAEENQSWTPPSPLGHRSSRTDYSHNKGKLLISSSPSSTTLASLHSYRSAHSSGRTASHMGTDAPPRVIQTTSQSLRPRASASDTLRTYAQVSAARGYLRHMVSAPNIPRQRLPLTCESSADRRSVCLDERAPPALPARWFESISKAVLGSDTGRAHMGGPVPSSSRDERARSSKFTLSDRTNHPAVGRASGLPRGLSAYLQRSETAPGAVSTAQVMCRSAPASRSSSRVRGRTSFGSFRDPPHSSKRRQGKGGVPILASTHIENELWGLQWVDRGRLLVPRAGAESVIENREDEEEEEEDDDDDDDEGELDLARILVPPKRQYSIQSLRKHLHTGRRPPSRGGVRDDEDDDIVGGHWRTRRGSMDEGQHAYAWAALGAPGFERPAKRRTGIPRGWTGLGRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ54</accession>
    <name>A0A401GZ54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027762568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ54"/>
    <dbReference type="STRING" id="139825.A0A401GZ54"/>
    <dbReference type="GeneID" id="38784373"/>
    <dbReference type="InParanoid" id="A0A401GZ54"/>
    <dbReference type="OrthoDB" id="3239894at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="730" mass="82630" checksum="85727E185679D34D" modified="2019-05-08" version="1">MAPGPTKPTAEEIQHYNMLVVNDLIDLYDNGVVYYSERFPKGHCVRVFLLAIICDHPAMCKMGGFAEKNHKVAPCPKCKVPLSELFSEKSLKNEFEGHNGEEHRRNCHHWHDLKTEVERKNFFDSYCVIDPMHNILLGIVKTQWYAVWIQGSGSALQSSTEKTPRELNVIHRFLEMFESPSWAGQLPARIGEPAGGSLTADEYRSALIGPLAIVIPIVWEAFIEDSQDQYECAKKRYDTALVKYKKELAAWERNFAKKHGETSSAANQQAQHQQPGDSSTHANIALEHQPPGESSTGANKPVQHQMPGEVSMQITQANKNVQEQRHGALSMRKKKDPQKSHEKSTPPKKPARRMQQDEPINFLCLATAVKLFLGRSITDDLVVRALDLLQDYLLEFRTVQFLSTVIALFSIPCCLQLYGEGAMKPNFHWVVHLPDQIRDYGPVYNFWAFLSERLNKILKSYRSNTWVGGQVEISMLREFERSIHLDAMINEVVSAGSPAREEAKLLLKRMLGDADQLLTGTAESSQNDELCALQVQAGPVASVAPQLSDKAHLGLFVYYNQNMQRVHYPTDHNPPSSTRLLQETAQFYDWALLDGRRITATSRTQQESAHSSIVKVLYAGKAYGGEVVCIFHHSQREIAEERLFAEFQWMKPLNLSPVQDDPWSEFPELEVETWVLGEFALAKAPGFPPPVLLFFTIQCQLSRGIVSTTNPKMWITMTMDRHASRFVTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ79</accession>
    <name>A0A401GZ79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1101350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618372.1">
        <property type="nucleotide sequence ID" value="XM_027762571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ79"/>
    <dbReference type="STRING" id="139825.A0A401GZ79"/>
    <dbReference type="GeneID" id="38784376"/>
    <dbReference type="InParanoid" id="A0A401GZ79"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="64"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="498" mass="52928" checksum="7055339EC124519B" modified="2019-05-08" version="1">MFSSLSQKSSLLCAALASSSLAFSIPFRREILPRKTAHSVTATKQAATSVDTLSGFDNVANERYIGDITVGGTAFEVILDTGSNDLWVDTAGVSLDYFYNTSVAGEINYGIDGQYSFAEGFILQTNVTFSNYTVDQVFINALNVSATGVLLPGVSGLLGLGPPTQQSVASSQLQLGSSAFSGLTVLENIFLRNTDIPPQITIYMSRNTGTGEIDGGEFTIGEALPEYAQIADTPQLPAIDSPLGPLWTIQFDGLVINGQTYQQTGVGSTNFTASLDSGTPTAFIDSYFYDRIYGSNPNSIPCDTQINVSLIISGQEFPIHPIDLTIPESGTSVSNAICSAAMYSLPNSPGMFLLGDTFLRNVYTLHNFNNYSQVGDPLPYTQLLSVTDANAAAIQFPSLNIARLEAFNTSDSSSSATVSGDLAEASSTPSPSSTPNLSELTRNTYIIMGLLGGALLLLIAIAIISIRNHNQTRGYRRVGGGGVDILASDKPYNPQYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZE8</accession>
    <name>A0A401GZE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1102180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618454.1">
        <property type="nucleotide sequence ID" value="XM_027762653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZE8"/>
    <dbReference type="GeneID" id="38784458"/>
    <dbReference type="InParanoid" id="A0A401GZE8"/>
    <dbReference type="OrthoDB" id="2886535at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="64006" checksum="0BF6D62A40AA6921" modified="2019-05-08" version="1">MVVEADHLEQTDEKQTSTGEVIQTSRGGSNLRFPAELFHSIFSHILHGNLAEESPKKALENLTLTCKVFYHLAQPLLFDSCTFPISRTWKPPPEEGVIYPSHADPIPMNIIPLSVQESEDTLHKLCFIGQERIATAVRHCRLAPIAYPEYSTPVDDHCQEDAHEHTIVDRFFRDIIPKLSNLRILELVHVTLGPSHLRLLHGVCVQLHSLCSETCFLQDDDEMRLEDHNHFGAMLSVKNLICKRTIHPGNRKMYLPLPHPTHVESLSYHFFSFRRRGLSHSMEGRERVLFRQLTAMGKFTSLRSLDVTIRPYGAVCDWRQFISTHCCLIESLSMQRHTKVNISFVAPHDLPSLKLFRGMWDDVRFYALQQGGLRHLIVTGKRADAAEDGLRNHPILRHSDVLAGLNGRRDEFACLESLELKIWNALEKIIAPIFNCCPRLRALKLIGNTSFGVGLSSLSSVFIAVTLCPDIEYLSLPQFHIELGQRASLESMISSSSVHLRTQCPKLHYVHFELREEMPMTKGSRSPVMKNSDVRFDPTDDRILTVEHTIEDWRSRVWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZF2</accession>
    <name>A0A401GZF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1102210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618457.1">
        <property type="nucleotide sequence ID" value="XM_027762656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZF2"/>
    <dbReference type="STRING" id="139825.A0A401GZF2"/>
    <dbReference type="GeneID" id="38784461"/>
    <dbReference type="InParanoid" id="A0A401GZF2"/>
    <dbReference type="OrthoDB" id="3255291at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="812" mass="88336" checksum="E129D491563CC159" modified="2019-05-08" version="1">MSWRNQYQVWTQPQNAPAGWAGSWPPTAPAGYPGPPPLPAGVNVNPQQWVSGQWMFNPMYRGPVSSTQGSFQMWAAHPSWGPGVAHASAAAAAATNYNPYKRIPNRGDAEYWKTKLLDNPLGLENMHIRDDTPQEERHVKDSPNGVPHTPWVWVPRELGKPEDGNSSDPRSAQSVSAAPAAPAQPPHTRDASRAPDSHPRANTHDGLSHAPPLTHTHAQERSASQPLVTPRHPHKLYGPFPPTQSFANEGSSPPGYPPDSQRNPTSGKPPTVAPRAPPIIAQGGVIPPPPEPLPPGSAASYAAYQHQQQLKQQQQQQQQQTQRQPQQQFQQHQRTQSRDVSPRQSEQTRDTRTSPRVSVSTASAAAAAAAASRVPVSSTSSASKSQSHSRSEAFSTRLDLHPTFSTSIVRTPDHYSAASSTTPTRRSSHDDADRTPSRPPVSPYSHGPIYGPPTPTRSNSTPSRHSSTASTTASSASSAMNVTPSILTSVSSFSEEPAALLSPLVGIPAPHTPNGSSPSSRQLTRSQTYPFESIPEGRATQPHTPEARTPRTPRTPRPPEREREQDRDPNATPHVVPRTPTHVTPDASSRQLSRSQTYPSLDSSPQPSPTHAPSRSRPSPSSEHTRQLSRSQTFPMLDPSPQPSPTHTRSRSRGPSPSEHARHLSSTSSNPLPAPPRPSTYVSSASFSSSMSSTQQSHHTHTTSVSAAASAAHNRSLYIERRIGYWNRRGDHLIVEKDRQFIVYAPRSLANPSDLAQYPTPTEGFMDQFGNKIKYDPTVPELSESLPLHGEPPKQPYDRFVHYMSVYTGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H050</accession>
    <name>A0A401H050_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase apdG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1200220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618710.1">
        <property type="nucleotide sequence ID" value="XM_027762909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H050"/>
    <dbReference type="STRING" id="139825.A0A401H050"/>
    <dbReference type="GeneID" id="38784714"/>
    <dbReference type="InParanoid" id="A0A401H050"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="519" mass="57701" checksum="A2C334B573B04325" modified="2019-05-08" version="1">MTSKTLKKFTREEVAQHNNEESLWIIVDSKVYDVTRFKDLHPGGASVFLDEGIPGEDATEIFYGLHRHEVLERPQYARLQIGTIEDEEQQIRGKVIGEISGVPYAEPTWLVGGFKSPYYTEGHRKFQAAVRKFIDEVVYPDAQARELDGKRPSLSVIDKMAEINMHAMRMGPGKHLKGLTLMNGLVTPEEFDYFHELIIQQEVTRCGARGYGDGIQAGCVIGLSPVLNFGSPEIKARVIPEVLGGKKFICLAISEAHAGSDVFGLQTTAKKTEDGKYWIINGTKKWITNGMWADYFTIGCKTEDGFTVILVERSDGVATKPIKTSYSPTAGTAYVTFDSVKVPVENTLGEEGGGIFVMLSNFNHERWVMCCTSARGQRLVIEQCMKWVTQRKAFGKPLSSQAVVRSKLAGMIARAESVQNWLENITYQMCNMDYKEQANKLAGQIAFLKMYSTRCAQETATDAVQIFGGRGVTQSGMGQMIEHYHRTIAFDAILGGAEDVLADLGVRQAMRSMPKDARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0L9</accession>
    <name>A0A401H0L9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1201870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618874.1">
        <property type="nucleotide sequence ID" value="XM_027763073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0L9"/>
    <dbReference type="GeneID" id="38784878"/>
    <dbReference type="InParanoid" id="A0A401H0L9"/>
    <dbReference type="OrthoDB" id="3267800at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="376" mass="40718" checksum="2EEF2307449AAB39" modified="2019-05-08" version="1">MTARPTYTSAPPSEQSIYFDAPLMHFFSKKSSDDDTSDGSGTASPAQDVAQQPNSDGDSSHRQSVSILDNSVVNTRSADGEDGACKNSAHQANAADAAGEAGSDSGYGSATQANQNQVRSASPASQTSTGMQPIPIIWNGKESQDEEQASWKRNQNQQTGGDTPVKRAASMRSYRSNDRNRDSIGNGAFNERRQRASLSGGSFANGAGTIGPASIPPTDDGLEERNAQVDAVLSPKDKSKVDKAQRKDAKRMSKVIKSEGKAEQQALEAVIKELANIQKMQKDAIKEESKASDAHSRALKTFHKEEAEFFARRAGYERAQADLQALEDAREAASTRSHEVTEMLQEKNREAEHLRTQKLIDDCEREARLKQLSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0S0</accession>
    <name>A0A401H0S0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1202050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 7">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618892.1">
        <property type="nucleotide sequence ID" value="XM_027763091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0S0"/>
    <dbReference type="STRING" id="139825.A0A401H0S0"/>
    <dbReference type="GeneID" id="38784896"/>
    <dbReference type="InParanoid" id="A0A401H0S0"/>
    <dbReference type="OrthoDB" id="435022at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000002">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000005">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871:SF1">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="488" mass="54296" checksum="74D7135386A963A2" modified="2019-05-08" version="1">MGGPTQSGNDNLTVRDNRTGKVYTIPIGDNAVSATAFKAMIAPRKPGEREENETEKGLRVQDKGFLNTAVIRSEITYIDGEAGVLRYRGYPIEQLAVHSSHLETAYLLIYGALPTKEQFGFFQSEVLLHSVIHSDAEGFFRSFRYDAHPMSMLTSAFAMLGSYYSEANPSLQGQRLYTKGDKISLATMDRQIYRLIGKATTLAAMAYRIRQGRDFVTPPTGLSYTGSFLYQMDHLGEENYVPNPVLEKALDVLFLLHADHELNASCTTVLQTGSSLVDPYSAVAAGCASLYGPLHGGANEAVIRMLISIGRPENVPAFIEAVKRREKTLSGFGHRVYKTSDPRSFIVRKTADEVFKVTGKDELLETAMALHDAAMKDEYFVKRKLAPNVDFCGLIYRAMGFPLDFFPVLFVVPRVVGWLAHWRQMMLQEGGVKIWRPRQVYVGAGRRDYVPLEQRPGVQDARQTPSAVEHGGITKRSMLASFEGKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H272</accession>
    <name>A0A401H272_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1303300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619427.1">
        <property type="nucleotide sequence ID" value="XM_027763626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H272"/>
    <dbReference type="GeneID" id="38785431"/>
    <dbReference type="InParanoid" id="A0A401H272"/>
    <dbReference type="OrthoDB" id="2796638at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="185" mass="21772" checksum="60D0236300387A01" modified="2019-05-08" version="1">MATTQSLRRAMNDLKLEDKDRSDQERGQLMLYPVDIKISSMPAQLPPLPPDYQTHERHYTLGWRITNSWVRNFGLQASSRDVAMRTSNLFWLGLKQLKWWSGYKHLCSFTTLADGAPIPPRSTTGEDAPSQTQRIIAVTFSATRELLKRRPTQAQYDWFVQLFEEEPIWYRDLLPKDRWYLHDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H295</accession>
    <name>A0A401H295_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1303280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619425.1">
        <property type="nucleotide sequence ID" value="XM_027763624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H295"/>
    <dbReference type="GeneID" id="38785429"/>
    <dbReference type="InParanoid" id="A0A401H295"/>
    <dbReference type="OrthoDB" id="2796638at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="117" mass="13416" checksum="595952730C938FA4" modified="2019-05-08" version="1">MLFEQLEQQHAQPTRPQIRAVDLTVPSPPARYPPLARATTERFYALGWKISEEWLKDFARRTCSKARIKHTHSLIVLGLVMLKRYAKYEHMNCFVVIPDNVPLTATGDDSTQPILAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H325</accession>
    <name>A0A401H325_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1402070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619715.1">
        <property type="nucleotide sequence ID" value="XM_027763914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H325"/>
    <dbReference type="FunCoup" id="A0A401H325">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H325"/>
    <dbReference type="GeneID" id="38785719"/>
    <dbReference type="InParanoid" id="A0A401H325"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019019539" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="132"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE88802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="372" mass="40414" checksum="3C4F526732691447" modified="2019-05-08" version="1">MKFVFSVFAAAVSLGGVWASNVLELDASNFDSVIGHGKPALVEFFAPWCGHCKNLAPVYEQLADAFAYAKDKVVIAKVDADGAGRPLGQKYDVSGFPTLKWFGPDGGEPEKYEGGRDLDSLTAFITEKSGMKSSIKPPPPPAYQILDVSTFNDVALNKEKDVLISFTAPWCGHCKRLKPIYDEVAKDFANEPNCVVANVDADAAPNKPLATAYDVQSFPTIKFFGKDSKEKPEAYEGARTEEAFVEFLNEKCGTQRTVGGGLTEFAGRLPEFDTLASQFYAATGAARDEVYKQASALAKTVGPAARHYVRVMEKVVNGSEEYIQKETKRLVSILSKRTMLPTKLDEIKIKANILGAFAPVKRETGGRAAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3C9</accession>
    <name>A0A401H3C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619858.1">
        <property type="nucleotide sequence ID" value="XM_027764057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3C9"/>
    <dbReference type="GeneID" id="38785862"/>
    <dbReference type="InParanoid" id="A0A401H3C9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="328" mass="35475" checksum="C8F1F2D2FD263CC9" modified="2019-05-08" version="1">MYRSQVWSHRGGQTGVSDASRAAVSPHGGVASGCVGRQAHRSVHRLAHGARGGLIQTAQRGVYTVYSPSFGQRTSVEEDSGCCPAGAWRLLASGASPRLALAAVYRDTGIPRTDATPPSRRIRAVPAQSQPQCHQSAVPSAHAHLGLALPDKLPARPPGTHAWGYALAPPNPSILPISGPPWRKRALKSRRTCPACPTWSSDRVPGERIRTRSGRTRISYIVYCILRPPRRTFQLANENDADWRAIIPAGLGCRTTTTPLLYWGGGGGRDNVPGHPPHVGFVYWRKERDAAEGKGVQLRLPSPYCTRVASVHTHCPQISQPCSNTWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3H8</accession>
    <name>A0A401H3H8_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619876.1">
        <property type="nucleotide sequence ID" value="XM_027764075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3H8"/>
    <dbReference type="GeneID" id="38785880"/>
    <dbReference type="InParanoid" id="A0A401H3H8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="181" mass="20691" checksum="8CB76B6D4FA13AE7" modified="2019-05-08" version="1">MAISPVYEAVYLHIVVQTSTSEHHLHAPPVPTDPREIEHHSHRQARPLIVVEPGHHLAADTPPLSHVSVKMIRAKPPSRLQFCLYAVHIPSMGPIPTHRETRYGSLYIDHVPASRRTFVEYLAHTDPEMIIMDASSTTHRPYHDRGAQRKSARRRIFWRAPQTWRPDAARAQCYVMQGDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3V0</accession>
    <name>A0A401H3V0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620007.1">
        <property type="nucleotide sequence ID" value="XM_027764206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3V0"/>
    <dbReference type="GeneID" id="38786011"/>
    <dbReference type="InParanoid" id="A0A401H3V0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="144" mass="15893" checksum="31ADEE99FC195CCA" modified="2019-05-08" version="1">MELEGEPVLHYSFLDEAASLPSANGVGIPLQLYPNHCRWSPEGYDELITEIPIGIITPDIFAQAWYNVEHPNTIGTPTESYPPLALSTSSLQVDTAELDDLQLSGYPDYYQQDLPFQTLTQPSTTPSPHATSSCTGRRDPLPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H497</accession>
    <name>A0A401H497_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1502650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620170.1">
        <property type="nucleotide sequence ID" value="XM_027764369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H497"/>
    <dbReference type="GeneID" id="38786174"/>
    <dbReference type="InParanoid" id="A0A401H497"/>
    <dbReference type="OrthoDB" id="2800280at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="390" mass="43798" checksum="16B0AA66C51DB0ED" modified="2019-05-08" version="1">MMSVASAASAFTLVERSAHSPVSVISAEDVARMEKNAYAREFYWFVSLRKPVACVQLKVDGHSAIRRCGATLRVQYFSEKSSSSRSAGGVPGIMRLRSLPSVPLVVLDVRLQVYFYRMQCMISETCHPLVIHAEAGCVVRSIISCSEPWVARRCISEWAQRLFFSAIARLDYSRTVAVIVHDIMADLFWASWDKNWYFEEKLLDLAMAAFIISWRSTDLHVFGSGTGLDALTDFLENMRSQLLSITSFVGDLFALGILPPSDMCLLISVLIDVPWSLIHYRGLHLLLLRASLHVGECVPREFLEQIRATIVWKAKHDIMSVRNDMAQRWVLEICNVIDTTLSQDGVRAIMISKGTQACHRWAEHLSHAELARLLRGIPVHDGGLFGALMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4A7</accession>
    <name>A0A401H4A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-induced GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1502830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620188.1">
        <property type="nucleotide sequence ID" value="XM_027764387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4A7"/>
    <dbReference type="STRING" id="139825.A0A401H4A7"/>
    <dbReference type="GeneID" id="38786192"/>
    <dbReference type="InParanoid" id="A0A401H4A7"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF131">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="76"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="666"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE89275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="761" mass="85403" checksum="4CDDE62FACFA9A80" modified="2019-05-08" version="1">MYKKSRLRRLGTTSPLSPSQHFHSDDMRKAPPHTSVTSGRDGGSAGVGLSDKQYSAGRRKMLDLINRLHKTGVQKEIDLPVIAVIGSQSAGKSSLIESISGITLPRASGTCTRCPTECTLSFSAEPWRCVVSLRFTTNENGETIPVRNDPFGPPIFDKPDVEERLRRAQRAILNPSIHARDFLEGVDEDPVTRERTFSTNCVSLSISGPDVADLSFCDLPGLIATEGTGAMKGDIQLVKSLVASYIEKPSCIILLTVACETDFENQGAHQLAREYDPDGKRTIGVLTKPDRIPLGEEERWLRFIKNESEPLENGWFGVKQPDSRALAAGITWSEARELEREFFSSTSPWAGVDLQIQHHFGTANLTDRCSSILSGLIAKRLPEIQSELQDMLQKTENNLRQLPKPPSSDALGEVFNLLTQFSGSLAEYLEGTPEPDGLLQSIRPIKEVFRQDILATAPDFRPYGRLPLPNEPQDNRRFIAPEFLSHETVFVPSDDANAVYIDDVMERANQSITRQLPGYFPFVVVEQYIQDVIGTWEGPTRTLFDAVQHILIQKIKQFIEIHFEQYPLLQQRVAAIVTSYILECSDQTKSHLDWLLALEKRPRTLNEHYYRDYRDKFLAHYKGAARNMATRPCVSQIVQGFAGLGIYGINPVDLPKVLPTDPFEPAIDVMASVRAYFQVAYKRFTDNIPNAIDHDLILGLKRDHALEKALRKGLGIGGTDADVQCGEYIREPPNVLLKREELQKKRERLVSARKELMDLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4G6</accession>
    <name>A0A401H4G6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620240.1">
        <property type="nucleotide sequence ID" value="XM_027764439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4G6"/>
    <dbReference type="GeneID" id="38786244"/>
    <dbReference type="InParanoid" id="A0A401H4G6"/>
    <dbReference type="OrthoDB" id="3174539at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48417" checksum="ACBFBB2099462EE7" modified="2019-05-08" version="1">MSLMQTLPSELIEGIARAAYDEGENKQDVASLMATCQAFRTPARSVLWESLSSIVPLLKILPERRWKMVQENGRNAFQWKDSWVFDRSLTARLEAYARLVKRFKWNKQRDITIPSLNALLVKWPGVLSNGIFPQLRYLKWEEDEVDDALSSVFLARIPGKKLQMIHLGWSQNAIYLTRPASDTLSHFLTSVVPPRGFRTFECTSAPVGYDGVRTLANMQDLQIAAFWPSIPDSFAPDNPQETEASFSSLRELHINSTVLGALEESLYSITAETLEPLLRISNLQSFILRCSYIKVDTAFLAGLAEACKCLEKLYLYSEKLMPFSCLRTVAQQFPRLISFGCHIDAKNVPEELPQKPDVPSTLGSLSLDVSPISNSELVAEHLAVLFPELERVVHVHKSDGKEALLWKAVETRFVPNRYRREYVPLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H533</accession>
    <name>A0A401H533_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1601730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620424.1">
        <property type="nucleotide sequence ID" value="XM_027764623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H533"/>
    <dbReference type="GeneID" id="38786428"/>
    <dbReference type="InParanoid" id="A0A401H533"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="52" mass="5672" checksum="F4EC1B026CD7DF74" modified="2019-05-08" version="1">MLPEWNIKGIIVELRSIETALNGSTASVPVHPGYQGSSSPDMAFRKMLEALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5K5</accession>
    <name>A0A401H5K5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1603370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620586.1">
        <property type="nucleotide sequence ID" value="XM_027764785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5K5"/>
    <dbReference type="STRING" id="139825.A0A401H5K5"/>
    <dbReference type="GeneID" id="38786590"/>
    <dbReference type="InParanoid" id="A0A401H5K5"/>
    <dbReference type="OrthoDB" id="2804661at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="115" mass="13022" checksum="397F8536685E4F9F" modified="2019-05-08" version="1">MAHGPHEAKDVDQEALELLEGRMFEISQAAGRAGYYQWGLDAGHHQDDWEPYKDLRSMWNHYDAEFSESELQTGPEYTAFEAPPPPAEAMSLIPAKRRPVPVPAYRGAKAAKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H670</accession>
    <name>A0A401H670_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1702610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620848.1">
        <property type="nucleotide sequence ID" value="XM_027765047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H670"/>
    <dbReference type="STRING" id="139825.A0A401H670"/>
    <dbReference type="GeneID" id="38786852"/>
    <dbReference type="InParanoid" id="A0A401H670"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="86" mass="9197" checksum="F66A380A00671C16" modified="2019-05-08" version="1">MTIFEQAMISSAFLEECITLARQNSQGPTSSPTDTDFSDLSLDDKYASSVSSGSPPHVISKVEATLYYAGISRSPPKLVYLGSDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6S8</accession>
    <name>A0A401H6S8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1801480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621037.1">
        <property type="nucleotide sequence ID" value="XM_027765236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6S8"/>
    <dbReference type="GeneID" id="38787041"/>
    <dbReference type="InParanoid" id="A0A401H6S8"/>
    <dbReference type="OrthoDB" id="2654126at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13783" checksum="08606B0503374C0E" modified="2019-05-08" version="1">MATDAGQSMREAAETFIEAHKPDHTPQVSNISQPASLTYAAAASQALPATHAQTLAREKTRACQVIVDGATCKHADGTGLNEDELLAKANTAIDLMGVARSDAPPNFKFKSVNCMHNGGITYTLDSPESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6U8</accession>
    <name>A0A401H6U8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase assembly factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1801270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621016.1">
        <property type="nucleotide sequence ID" value="XM_027765215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6U8"/>
    <dbReference type="FunCoup" id="A0A401H6U8">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6U8"/>
    <dbReference type="GeneID" id="38787020"/>
    <dbReference type="InParanoid" id="A0A401H6U8"/>
    <dbReference type="OrthoDB" id="5545577at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048281">
        <property type="entry name" value="COA6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47677:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE90103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10566" checksum="84FE11591FBBC1F8" modified="2019-05-08" version="1">MGWFGGVESTKPDPASRKDRQKCWENRDAYFTCLDGAGIVKPGEEGSICAASKTAYEQSCAKSWIDYFNQRRVLAEQQQGILTQKSNQDRASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G530</accession>
    <name>A0A401G530_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0101330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608173.1">
        <property type="nucleotide sequence ID" value="XM_027752372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G530"/>
    <dbReference type="GeneID" id="38774177"/>
    <dbReference type="InParanoid" id="A0A401G530"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25453" checksum="C11BC8BC1572101A" modified="2019-05-08" version="1">MKMSDAWENHLHLSLLGEHVLFRHLQLDSAWTFILASILTVFICLTERLLTYGLSNRWDPSRSCRSGSRLRILVWRTCLYWVVTFDRLLYMLIAMTFNLGLIIITATSLSAGQFVIEYLNTPAAHPPDPENVKEPLLSDCYEPPTRRESYPPPVNTTGRPRSKSKPESIFIHPSESNIARADVAAMQLGLSGDTDIVKWNAYPDNGDAWQLGKGKDVARELLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G535</accession>
    <name>A0A401G535_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0101500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608190.1">
        <property type="nucleotide sequence ID" value="XM_027752389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G535"/>
    <dbReference type="FunCoup" id="A0A401G535">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G535"/>
    <dbReference type="GeneID" id="38774194"/>
    <dbReference type="InParanoid" id="A0A401G535"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20646" checksum="60F3EFFA9C108B93" modified="2019-05-08" version="1">MNQTYPTITIDLVLDRHTTKEVLRAVLHSILFHRLFGTVKPQIFELLDVTMPGVDDPDMKELVENKVEAFWKGIEGVANKRGQIIVIFSEKRPRKTWFMMGEEEVPWEQWIINAEIRQPTTDKDRQTFNANLTSTLTKSLKTMLTHASSDRGRSAVPLITNAEGISPFPTKIVVKVGGVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G571</accession>
    <name>A0A401G571_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">SCP_0101890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G571"/>
    <dbReference type="FunCoup" id="A0A401G571">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G571"/>
    <dbReference type="InParanoid" id="A0A401G571"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="184" mass="21087" checksum="A7A2C2B639FCC177" modified="2019-05-08" version="1">MRAYFMDELPGDQRLLHDSGRPATDEILSNIGVLHWHVPLDAAGEWENEINAIAAERDYKNRDIVVVNKEAMGAEFETKTKAFYHEHMHEDEEIRYILEGGGYFDVREHSSDSWIRCHLGPGDLLVLPAGIYHRFSLDMGNKSRTMRLFKDEPKWLAYNRGATTDASPYRLDYLKTLDSVATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G573</accession>
    <name>A0A401G573_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0101840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608224.1">
        <property type="nucleotide sequence ID" value="XM_027752423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G573"/>
    <dbReference type="FunCoup" id="A0A401G573">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G573"/>
    <dbReference type="GeneID" id="38774228"/>
    <dbReference type="InParanoid" id="A0A401G573"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="79"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="270"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE77311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="574" mass="63336" checksum="46A32890DDD9F342" modified="2019-05-08" version="1">MATAATKALRVALRGGGILSHPRFNKGTAFPAAERKAFGLTGRLPYRVNTLEEQCHRAYDQLCTRDTPIRKNTFLQSLKDQNWVLYYALLSRHLKELIPIIYTPTQADAIANYSHLFRRSEGMYLTFPNQDSMEGDFLELTKGRDIQLFVISDAEAILGIGDQGVGGIGIATAKSAIYTLLAGIDPSKAISVTLDLGTDNDDLLNDDLYVGWQNNRVRGLAYDKFVDKFMQLVRKYYPHSLVHFEDFGVSNAKRLLDKYRDQHAVFNDDVQGTGAVTLAAMMSAVGVTKSRLADQRFVVYGAGTAGLGITRQLRDGIVTIDKLSEADANKRFFLMDRYGLIKESLGSNKIRDEVRDFVRPDAEWVGVPTNAQGEVELLEVVKKVKPTVLIGCSTRGGAFTEQVVKEMAKGTERPIILPLSNPSRLAEVNPSDANDWTEGKALMASGSPFPPCKNPKGGKDYIIAECNNALIYPGLGYGALITQARSLTDTMIIAGAQRLALLSPALKDPDNALLPDFTDAREVNFEVAVAVVEQAIDEGSANVTWKKEDVREKIHADMWLPVYPEFIYDEAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5Z1</accession>
    <name>A0A401G5Z1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608477.1">
        <property type="nucleotide sequence ID" value="XM_027752676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5Z1"/>
    <dbReference type="STRING" id="139825.A0A401G5Z1"/>
    <dbReference type="GeneID" id="38774481"/>
    <dbReference type="InParanoid" id="A0A401G5Z1"/>
    <dbReference type="OrthoDB" id="3248190at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="220" mass="25327" checksum="597FC2880C8B24BF" modified="2019-05-08" version="1">MRMETKQGIISTESRQDNEPVRHRSLYILDDTVVIRVEDTLYRVHRYFLKRHSSVFAGLFDLPPCPDKPVEGSGDETPIHLQQVASIDFERLLSLFYPRNVQNGDLATVDEWTSVLALASKFGFDEFRELAVARLSQIATPVDRIMLSRAYDMTGWLIPAYAELCKRDESLTLQEGLRLGMKDVIMLSHIRQTIRRGSYLTSIRMSDSDILTYIDQQLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G602</accession>
    <name>A0A401G602_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0104700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608503.1">
        <property type="nucleotide sequence ID" value="XM_027752702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G602"/>
    <dbReference type="GeneID" id="38774507"/>
    <dbReference type="InParanoid" id="A0A401G602"/>
    <dbReference type="OrthoDB" id="5231159at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="119" mass="13600" checksum="BB6EF1DE18517FDA" modified="2019-05-08" version="1">MKTRCLTLNRNEFLSCFVTDAVLSVIDNIVNGSKEMDPVLNLVKRDTVNARGMAKTFTTLRDKPLTHCENCGKSPEDFGRDTRFMVCSTCKSKLHFSIHYCSQETMSERRLEEAQSALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G839</accession>
    <name>A0A401G839_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0112020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609230.1">
        <property type="nucleotide sequence ID" value="XM_027753429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G839"/>
    <dbReference type="STRING" id="139825.A0A401G839"/>
    <dbReference type="GeneID" id="38775234"/>
    <dbReference type="InParanoid" id="A0A401G839"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033388">
        <property type="entry name" value="BAF250_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12031">
        <property type="entry name" value="BAF250_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="90"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="919" mass="100989" checksum="EFD29E1BA7C47B16" modified="2019-05-08" version="1">MSFGLDQYTAKQMAALQATSLAKAGNRSAPGGTSVPYFGGMQSSAHPRPDAPQDPRHSLGALSDFQQPGHHPNPNNMQASNAAMQHMLQMQKKRQWLQGLANVMNQRNAPLPPPLTGVPYPATFDPTHSLWKNLDIVDIGVVRLASKEVDLYKLWAVVLQAGGGSKLTQQNMWSAVLPYFDLPEQFPVPQSNGQQSVAIVLSNYYVTILGPFEEAYRRNIMREQQQRGLMHSRMPSGGQQHAPGSSQVRPGAPNMPPQMASISGLAGNSMNSNLMGLNQASSSQAVDSSVQSASGGQFSTPAIPPTPRLPSHPPSTGLSGAAASLGLPSADSLMSNPAIPQHGSQSNVSFSNGLDVATSALEHGIDRKRKMRESEEADAKRQKTEGPEAGPSVGLERGSAPPIPALSSHVAPTAPPTTTRVPRQPQRRKIEYVPLAREIETAGGRDLDMIQHEYVRASHRPLKDFNEWGQVDIEALTMSLRSRISTELSYALTTFTMLTLMRSSQKDGFPVSHTPDLFEEVLDLLEDVAFDGADDEDDVLDGPAPSSIRTHRELVNMLFEDSTRPFAGLDPRQGMKDPNIGLRQRPGDIVLSVVNILRNLSMTPENQDFLAKHDRLLTIVFRLCNLAPSKPDVLPTAASPALTLSDLITVRKDVVYTLMNIAGFVDLSKTSSHRPQVLRNVRRAFELLSSYLSDQIEAVSPFACMLQSGIPPAMHQPKPPSLADNALEAFTRLIQPDDNRHVLAQSVPSEWLWTLMEALVHRLPVSDSDFQVVMRDVWLSYIEKLVMAIYCIAFLAPPQLKKRIKTDRTLGFTKIMLRLVKKFTIYSPPDVRVYFVISVRRAIESMKLIDDAEDSFDTSQSAMPSLSFGMGYGEHGESRVEKGMGLLSGYQEEITWGLMMQRDVDETMFSELESLVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8C8</accession>
    <name>A0A401G8C8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0112850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609311.1">
        <property type="nucleotide sequence ID" value="XM_027753510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8C8"/>
    <dbReference type="STRING" id="139825.A0A401G8C8"/>
    <dbReference type="GeneID" id="38775315"/>
    <dbReference type="InParanoid" id="A0A401G8C8"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="193" mass="21003" checksum="BF6E731BA44A0D2F" modified="2019-05-08" version="1">MTHPDLLSTSSLLKLINPSGVYLLGYAWLCGMSIWVSFLGGVIALKTLPRHQFGTLQHRTFPVYFVISILLASALLGLWAYGHPAVLIHWDDPKVADVAQAYTLAAVVLLQAGNYFVVGPMTSRVMFKRHKLEKEESKGYDESGVSDSMKTVNKQFSALHGASSLLNLCAVISLLFHGLWIGNAGVGIAAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8E6</accession>
    <name>A0A401G8E6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.256</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0113150</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4 14"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609340.1">
        <property type="nucleotide sequence ID" value="XM_027753539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8E6"/>
    <dbReference type="FunCoup" id="A0A401G8E6">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8E6"/>
    <dbReference type="GeneID" id="38775344"/>
    <dbReference type="InParanoid" id="A0A401G8E6"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019118409" description="Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE78427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="467" mass="52875" checksum="9F5A5F7357D46171" modified="2019-05-08" version="1">MSSLPPSASTYYALFMAVSVLVLKAVNEEVTEPYMDEPFHVPQAQAYCRSDYSYWDPKITTPPGLYVLSLVLKRVFLLKCNLAMLRLTPLLCLLVLPIVMTRLVCYYRRERPPHSLAVPDPEAVVLSAFPIAWFFAFLYYTDVPSLLFVVSSIVSATQGKHWLAALLGAISCTFRQNNIIWVLYGYASSQLMYLRFRHALPNEKPYAKLHDPPALVATPSKSSFDLVRSVLSAPAIVLDILPSFVPYGFVLAGFIAFVLWNGGIVLGDKSNHIPAFHVPQLYYFVGFATIFGWPALISGKGGPQKLARDVRLRMFGGARNTAITGLVAIIMGMTIYKFTIHHPFLLSDNRHYTFYIWRRIFLLHPVVPYLLIPVYIACAWAWYIRTGQDQTLLQNILLAVFVVPTLIPTPLLEPRYFLIPYILLRAQITDVPVWGVLVEGLWYGTVNGVTMWVFLHKERAGVGRFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9L2</accession>
    <name>A0A401G9L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unnamed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609760.1">
        <property type="nucleotide sequence ID" value="XM_027753959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9L2"/>
    <dbReference type="GeneID" id="38775764"/>
    <dbReference type="InParanoid" id="A0A401G9L2"/>
    <dbReference type="OrthoDB" id="2927810at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019024266" evidence="1">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="160" mass="17981" checksum="7CCF8479BA4BC167" modified="2019-05-08" version="1">MKFSWTYLFQLISASLLVGRAAAAPTPEPQPNRAIEARRGDEYLWYIDEAESIHLSELLGVDFHRLGITGVLIDGPKMKCENCGKYTGLDDIVHSALEDGIHRKEYLVKVLEERESHASPPHVVRCSTAGCSRAYEEPRGWGSRWISKTETEENAHVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA51</accession>
    <name>A0A401GA51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 85 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0202510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609967.1">
        <property type="nucleotide sequence ID" value="XM_027754166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA51"/>
    <dbReference type="STRING" id="139825.A0A401GA51"/>
    <dbReference type="GeneID" id="38775971"/>
    <dbReference type="InParanoid" id="A0A401GA51"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="1">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="1">
        <location>
            <begin position="195"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="739" mass="82186" checksum="A0E2D58AF738BC66" modified="2019-05-08" version="1">MPLRGTDHCNASRDDAPYFDSLVDLDAWAKTSPAKLNGVLDYHPRQFVEGLPAESRGNLLVCHDYKGGYTESPSSLSYTFNLWSYCNTFIYFSHHRVTIPPSGWTTAAHRHGVKMLGTLIFEDSGEEDCLRLLIASRSLRTMRIFSHIWHISEGLTDIYSTSNAHYADNKSRRGHWQLGLLCCGMDFNGKLVHILKWYDSVIYNGQLRWQDRLNNYNLPFFIPSSAFFTNYTWPPDYPSRTAQYFLSLDTALVTQSKFLRDIFVGVDVWGRGSHGGGGFGSYKAISHIDPEFLGLSVALFGQAWTWESEQDRPGWTWESWWEYERKLWLGPQDSSDAVTVPESPLRRGELKCEHGPFVPLASFFPRHPPPNPAELPFFTSFSPGVGRAWFINGAKVLETTEGWTDLDKNCSLGDMTWPRPVPQWEHGGETEELPKASSALCMDDAWLGGSSLRIALEIPGSDTEDAFFRCIWLPVQSLAITPRNSYEMSVVFKVNSDRPLDFDLGLSLKVLAEDVTDMVDVTSVSITNADELPGGWIKMTIHCVLSSDHPSDVLAAAGLVVGFAVEDPTEPILVSISLGALCVRSGTASQDLTIPQPKLLWADFHQMPPAEGSAVFAGTLTWDVGSSFTSLPSVRNPVPDSEDPRPVWQLDSSFPVFSYFNIFAQVHSPEGTVAGPDCATFIGTTGLDGRENRFYVDSACLPLSATGACGIRFYVQGVTDWGLVLDWESSTFVDVKIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAH0</accession>
    <name>A0A401GAH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0203650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610081.1">
        <property type="nucleotide sequence ID" value="XM_027754280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAH0"/>
    <dbReference type="FunCoup" id="A0A401GAH0">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAH0"/>
    <dbReference type="GeneID" id="38776085"/>
    <dbReference type="InParanoid" id="A0A401GAH0"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="254" mass="27476" checksum="AD0E51D3AEAA7554" modified="2019-05-08" version="1">MASADGGAYSYSLTVFSPSGKLVQIEHALAAVSQGTTSLGIKASNGIVIATEKKSSSILIDDSMIDKVSVICPNIGIVYSGMGPDFRILVAKARKSAQAYWKIYNEYPPTKVLTQEIATIMQEATHSGGVRPYGVSLLVAGWDINRGPSLYQVDPSGSFWAWKASAIGKNMVNAKTFLEKRYNDDISLEDAIHTALLTLKEGFEGHMTEKTIEIGVVTVPSEADLEAGKIEGTGRAKATFRKLTEEEMRDYLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB57</accession>
    <name>A0A401GB57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0205850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610300.1">
        <property type="nucleotide sequence ID" value="XM_027754499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB57"/>
    <dbReference type="STRING" id="139825.A0A401GB57"/>
    <dbReference type="GeneID" id="38776304"/>
    <dbReference type="InParanoid" id="A0A401GB57"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29413" checksum="EC8E1BF1D1F322FA" modified="2019-05-08" version="1">MLEKKRAIYSDRPTLTVGGDMAGWDRVQALLQTGPEWREHRLLFSLFIGSRSKIAQLHILRSVGASILRLSHGCTAEEDVDYFLQFAESALAEFSYLTGGGPFLADAIPWLRYITEWMPGAEWRRNVKIWAKHRRDMQDLPYRFVQGQVAAGPALPSLLSLRLQEENLTSEQEEVAKFIATSFFVGGTDSTAAARYKQLLLDYDVLAKSAAEGPDGNRQCDWERQTPRDRRQVPAALPQCSMLGDLPVKSCHFTSLPLSQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBA7</accession>
    <name>A0A401GBA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized THOC5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0206600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610373.1">
        <property type="nucleotide sequence ID" value="XM_027754572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBA7"/>
    <dbReference type="STRING" id="139825.A0A401GBA7"/>
    <dbReference type="GeneID" id="38776377"/>
    <dbReference type="InParanoid" id="A0A401GBA7"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23788" checksum="7C8C8E9059622E19" modified="2019-05-08" version="1">MPDAFPDDTILPPAPEAVVDALNSLVSSGYLNYDHTAVHNRAGALFARLKALNRAANAATRTHKQATADARHDMDQTYLGLQNLLYEKRHLEREIEKCQQFASVYQDIPLYSVEEFIRLAPEHAKTERVLNDEHELMLNRLSFELAERQRLDQKQKELVKQKEELLKESKVQLATMDNVKVQIDTLIKTATEVQKKVGELVQSVPAQGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBQ1</accession>
    <name>A0A401GBQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0207890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610502.1">
        <property type="nucleotide sequence ID" value="XM_027754701.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GBQ1">
        <property type="interactions" value="710"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBQ1"/>
    <dbReference type="GeneID" id="38776506"/>
    <dbReference type="InParanoid" id="A0A401GBQ1"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="96"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="749"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1127"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1032"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1454"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1550"/>
            <end position="2162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1088"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1454"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1497"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1559"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1576"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1600"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1683"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1703"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1727"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1751"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1880"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1893"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1913"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2018"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2040"/>
            <end position="2049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2082"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2152"/>
            <end position="2162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2162" mass="239999" checksum="00FC982595A58A7A" modified="2019-05-08" version="1">MDPLSLDVVHAAQDCLAKWENGGSASCRKILMEPHSNPLDPSCNDVLTTVYHTLLASTLSSWSPKHTLTTDSFIVFVQSVLDHVPSSSISAVKSSNTVIFGEILVDIVWTIDAELEEILADTKAATNAEQGSAGLTAKDKEDIAATVAKVLRSKQNAEADKATLATIVRRLLTLGVLDTDVCRERLDISLIANAGLITDKNAFERKEIRTRTGLFYKQNKFNLLREQSEGYSKLTTELTSCLGPPNSSATGYPVESLTSIEARARPAWERVVGLIGYFDLDPNRALDIILDIFSTHLATHHTFFVSFLSFSPWSVRRKEHRSGKEDAMAVGPDGNQYRGKSLDEVLFAAEASSNPWTAEPPRFSSEGSHTRVLAQVLGFKFSHYQSPEVSEITPHSLFLMTAILVREGFITLEDVYAHISPTDEDMDNWRKEYLATVDARISGAKISQLAMAAPLESGTQSSKSRPAVSSEPKRTSETKEVPNQKLGLLNALLSVGALRPAVAILSKFPWLVDAFPEVADLMLRILKLSLSALYDSTQPTKERNASFTQPRARFGPTGVVAAPERKPHLTLCAPTPPSTINIDFVFFFPDWSQRVPICSTLDDLVDVIEPLMHFIGLHISRDNSFFTKFLRLGRTHLQQTVVLDPDTRKPTSSTDLEHPIRLFWFKILRLYLLPALPLIRGNAVCTVEVWNIMRLYDTTLRWQLYGEWKSSTYKSHPELRLRRVQTDRESKGILRRVSKNTMDTLSGAVAKLAHSNPCIFFANAVNQIMAYSNMAEVVIQALNYVTIMGFDVLVYIVLEALANPHKDRFKIDGVNTSDWLQNLASFTGMLFRRYSADLNPLLKYIVHQLHGGQTTEIVVLRELISKMAGIEPLPGMTDSQITAMAGGPVLRIEAVASRNRGARLDPSDAGLKGPQRLGRALLESSLAQPLLIQVAQQRQSCVFQAPNAHLKSLANLYDTTHGVLLQYIELLTSPAVVPPQDYAQRILPSLTDLSEKYGICAPICMQMVRPVLSGALLSAALEMQERERVASEEAEKRLKAALTAKREPNASTSRVASPGMGDNSTATESHTDARASVAETHAADVSMESPSEGQGNSTPHTTESPWLPELYPYFDVVKKIAPGNAAEIMGPGFYLTFWQLSTYDLTPPAARYDEECAALRALSRQEDARYNAADRSSDRAKRLTAANHRDRRNRYNTYVNLLGQELKEQTAARVFTIKRLAREKQHWFSHNPKAAVLAASFIEHCLQPRCLLSPMDADFCAQFIKVIHSQGTPGFSTLMCYDKILGDHVKVVIFSCSEYEAKNYGRFLLGILTDVAKWYLDEQAFLQENRTKTGGKTTYLPGLQRRWTAKSALTIEDIIPWLDYKQIVRKWHRKLLKCLLDCIETAEFMHVYNAIVVLKEILPAFPVATVNEYAGSSLNMAMERLLDKEDRGDIKIFGRAYLASLKKREASWMAPKTKAAPAGTASRPATNGADKARTATPPVNPVPGGLAAEVRRPSSALPASTPSAPRAQLAGINGTPHTVGDRPGSTISSTKLAMESVPRPDVVKRVRTDSRPPEASQTASHVKATTNGEPMDVDHPIPRVDENAINTSLPARPSRVVSTNVQSAQYDNTVPTPAKDLPRPPEAPVASISDEVDGGRTLAGHIPRPLQVTAASEQKVPRVDSPQTMPPPSIPSQTLSAQELRETAKQSRSLSEKNEEKQPQPSTETRSQAAPAVPSPSSRRRSPSPSSRPGTRNASAESRASGGRRSNRGDGDRSEEKRSEREARQDTRDLSRRESASHPRGEGNTRRTRDPDRDKEIERDRDRGRDRHGDRERGRDRDRDRDRDRDKDRDRDRDRDRDRDRDRDRDRDRERDRDRDRHRRDEKDRDRDRKERDAATRGSSAATTTPAPTDDRGLPTRPDPSRHRPATQHSDDALGKRRRLTDDDSDRNSKRSSRKESHHEDRSRRSSDKDGHDRPRESDRRRKEREATESDNRSLAVDTKFGDKRIPDGPSSAKSLPPSTPSAPRAMASGDGSRNLKPDPSAPRDRDWKVTPIGPSASLGSVSSSQDVGISGGSLRSRIGAKEPPPLPQAPSSYRSEAAADRKSDLPNRDDERDGSRKRTLSEREKEAGDAAPGTSESAGPPKRPRINRNRYPSIHGVVKNLLPLEQQADKSRTSRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBU0</accession>
    <name>A0A401GBU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferredoxin reductase-like C-terminal NADP-linked domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0208440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610557.1">
        <property type="nucleotide sequence ID" value="XM_027754756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBU0"/>
    <dbReference type="FunCoup" id="A0A401GBU0">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBU0"/>
    <dbReference type="GeneID" id="38776561"/>
    <dbReference type="InParanoid" id="A0A401GBU0"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="75"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="39680" checksum="2C5DF9F709A618D9" modified="2019-05-08" version="1">MLVWKASSVRSLSIPLRCIFGRQNSTNSSIYAPKRRPSFVIYGVLGGGAVATAYFFWPDISRSAPTYSNALLSPVHFIPVTVSSTVACADPNSRLITLTVPPQCLPSRDESAVGPVWSIFIKDDDIQVERPYTPLEGIDKEGRMKFWIKKYPKGEVGRWVHSKNVGDKIEIRGPLVTWKWQENVWDEVVMISGGTGITPFCQLLYNTVLQNPSNPRRTRFTLLHGSYTPAELPPPAMLEPLLSTAQTHPDRFKMSLFVNSLDGPSHPSLSSSAFQVGRIDRGAIEHALGIDNGFTVWWKALLRMKTPADRTKKTLFLVCGPESMINSIAGPFGRNFSQGSIGGVLQTMGYGSHEVWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC34</accession>
    <name>A0A401GC34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0209180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610630.1">
        <property type="nucleotide sequence ID" value="XM_027754829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC34"/>
    <dbReference type="STRING" id="139825.A0A401GC34"/>
    <dbReference type="GeneID" id="38776634"/>
    <dbReference type="InParanoid" id="A0A401GC34"/>
    <dbReference type="OrthoDB" id="3268641at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="540"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="642"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="890"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="986" mass="105389" checksum="DFB27CDF6967ED35" modified="2019-05-08" version="1">MRRLAAVFAAKRTDRSDAASSVADDSPAAPPSQQLSKPRSRFFRSLSRKAAPPAQSLVVSDHTPSSSSSSSAGPSTPDDDGTSSFRAAASRKNWLAWHHDTPPAPQYISAPTPTSRSVPPASPRHGSEEDLSSDESSGTEPEQPLSPTVVAPQRPRICLTPSSSDHSHSSARSGPLSPTAYVRALTVNALLSAFSPPPLLHVPNTPLFPRSCNLRRTLPPLSADPVCPSMLRRHLLRRLDRARTLAPSEQYSLAPFASRRGHPTAASHRGPSRNSVQTIDDVAVSDGKRIGMHSDGLRLWAERPCFEDRMVVYLPAHPGSVQNVVCIPVSGPGLGVAAIEFSETLELLAGLYDPDAEVAATAEAEDANVLPAWLLDVTLTPPLSLSSSATPESSGPTTPTSTSPMPSPVLSGSSKPPELSVTLPSPPPRGQLYKAAPSPLRIEHSQVLFSIPPTSPRRTASPAAPTPTVSPSPSSSTGTSVTVKPSSPVHTKPNVRFAESVPADAPGMDAYRTDNIPLGYVQRIKHQRAEKARFLAVERARRDEAVRAEEQRRRREAERRALEEERKKRLYAEEVARARARRESMRVDPDWEIAREKERERRGREVRPVLARPAYDAQPAPAPRRQGSAEPNVRRDESPAQRSAVAGSRSSSVRPASINGSAAAEHGSPAAAAATRSSSSPDVRHGQGQGRPNASRRGSMVSDAGSRPSPAPPGSPAWMSSPNGSPRMNPRLSMNMGVPSMPMQMVQVPMPMQMVPVPVPVAMPYALPMGMYGMSAGMMMDAPLLPPSPPFMVHQFGYRAPSPAQGPSSQSRDHSRSRAHSSSPAPGPRDHAHSSSPAPGHRDHAHSSSPAPGHRDHAPSPSRSPQPQPQNRSHSSSPRQAAALLSPHTQQRSPMSPAQAPSPSSSAPRAHHQRRSSADVDVHRSAQPPPQSSDRRSTKSSAPRPAPTHHASLPPSVPPMPRSTRAQDGFQILSRPSAGRRQTMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC47</accession>
    <name>A0A401GC47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED17</name>
        <name evidence="9" type="ORF">SCP_0209310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC47"/>
    <dbReference type="STRING" id="139825.A0A401GC47"/>
    <dbReference type="InParanoid" id="A0A401GC47"/>
    <dbReference type="OrthoDB" id="10251234at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10156">
        <property type="entry name" value="Med17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="637" mass="70588" checksum="F136E57EB931B75C" modified="2019-05-08" version="1">MRDGSPWKELKLSLERPYKDDEGHPIPVLLDITPDGEFIYEPKEDYYAIVGDNLRRIFVERGLDFFEKRHKQRKVEPTIEEMRDKSSLEEKRHVMDADELLKMRMEVLPQLYIALGEMSQARDLLALLLSSPNIPQVAPNSGSQPSALTVTVVTKQPAIPSVQAFNAQLAAGGKDQALRNAADLFKFAADRMETGRVMAEKYWVDALKIRTGNWGLIPAPLPFGSATGKGADKTSKDFLVSFGLEESPPLFRRRAIARMSMQDNRVSALEFPSRQNTRLQVTVTTTDGRGVRHTTQNRMVLFDGSSVGQSLHAARAEVVEQEIFSALIREASHLPTASARVSERLIVIEAAQATDLQFELVDKDPSQSKACAGDGDAICDLISGLLHILLLRTHAYLKSERLGMSIHRAPAPPSVVHTPPLLQPIIDMLQYRVFCERVHGELDKISDALSQACVPTRSHFEAVGGTGEEFLMSFRQGKAKPVGGEARLRVDNRSTLRFTFFAPSSLIAHLPQATLPITSIPQLTQLLADEVRQCLLARICEIGSELCSRVKGMWFVDMLTGRSVGRWEGCVLNFDVSFGKEPSIVATASRMNRANTHAAVLLQSFQSREGEGTSLFEWTRRAIGTALSQHSPAITHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCM1</accession>
    <name>A0A401GCM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0211260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610837.1">
        <property type="nucleotide sequence ID" value="XM_027755036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCM1"/>
    <dbReference type="FunCoup" id="A0A401GCM1">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCM1"/>
    <dbReference type="GeneID" id="38776841"/>
    <dbReference type="InParanoid" id="A0A401GCM1"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="180" mass="20025" checksum="DB00D94396DC721F" modified="2019-05-08" version="1">MPAYHSSYNEEPDIRLVGNMALLPIKTKIRGPAPLADPSQADVIDETLDLFRANSLFRNFEIKGPADRLLIILILFVSDCLAKIGSARTVPSQLEAGKTLNTLSVDNFPIPGDANFVLNAHYAPPGSRADADYLRQYLTQARQELAARLVEKLYADGTGKPSKWWMSFQKRRFMSRSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCR2</accession>
    <name>A0A401GCR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0211520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610863.1">
        <property type="nucleotide sequence ID" value="XM_027755062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCR2"/>
    <dbReference type="STRING" id="139825.A0A401GCR2"/>
    <dbReference type="GeneID" id="38776867"/>
    <dbReference type="InParanoid" id="A0A401GCR2"/>
    <dbReference type="OrthoDB" id="3153758at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="304" mass="35691" checksum="EF37B63A73174232" modified="2019-05-08" version="1">MVRTTYSSTASPPPEYSSTYDPPNFYSQPVADERTPLNPGNTRRAAGPRNNRMYWQTINTTELIVIPTEPTATRTLGRSLLYTVLLLIVAAFIVENTWIATNCAEHRQELERWERERKDLERQREEERQQWEREKREDERRRREEERRRLGLYWDEPQAKNCVSYGTREHTARLRNIPSGYNWVQACEEMSIEIHNRTIDTPSRCEDAGASGIFGHWQVGFEEPACVPYWGDLYDKGCVGYGTRLHRFEARLWNLQKDDDWTNMCGTTPAVIHGVHHAKPTYCEYRGAFYGMVGMWDQSDLRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDI5</accession>
    <name>A0A401GDI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0214050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611108.1">
        <property type="nucleotide sequence ID" value="XM_027755307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDI5"/>
    <dbReference type="GeneID" id="38777112"/>
    <dbReference type="InParanoid" id="A0A401GDI5"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="915" mass="99509" checksum="F3CDEDECFB5CD1D9" modified="2019-05-08" version="1">MLSHSSADVPVLSLSDIMHTMSPSPAPQPPLPFDSAHVSLIQVDQSGIFGSHVDPTPQRHLSVDPLEQVELETMRFRVHQLGFTSPHSANANMTPAERELADMVLRLTSDPLLHPSPSQLASQAETIAGLSVQRNFLLREKEEEQARWQAERDGWERTAEALIGRRRAAQDAAEKDYEAERHIARLQDDNRALRHKLSESHSRMSTLESELNRLRPLLLVQPALLRDPSLLQLPALFSSNAPPKAKPEPKKGKRKSKKEREKEKQTEENEREAEALALAHALALTNAEEETTADKEVDAGTAIHTVAGVNATGDDQRDLMQVDAENDAPQLAVEGNALSDPSALPLEGPTSGGKPQDNDVKPDKQGKVKVRKTRKSHAGTSRDHATPLLSDARAECLLVAARRIARMRADAIADLAKEREEQRQREQELEKEERERLVEAADAQRLRTRSSRHGELDRGDDAGPSTHYAYGAMAHASSSSGRDAPASLHPNAASTSETAPIHGRPLQLPSHLHPSIQHSQQPPHLPLHPNSPHTVPQGFVYMHPRFADPVSGGPGTSQGAHGVPLLVPLPPGVWPLPGAPTSGKTNQVRTPVRNTGSSQGVTTPMDSLVSAARTMMDDVDESNADEVPRRRNATAAALDAQDSPVPKRRRSVTASASGSRMKPRSSRREPQPAELDLGGGRGKAKGKGKGRSGETPTDSGDRAKEPTPRSVPLSATPVRSALDVLAEQAAQEQGRWPSSGPGSRRQSLEPEMRLALSGFTTPRADSVTSVANTPTNNKGKARASENPEQELTSLDPSVDTRHAHSHHDSQNQTKFTTSHNPFVEHDYMVVPGLTPSFRRPPSAPPAPVDDPHVGHIGSIARIAEVLVRQGTQIDLQEVRRGVTIPVPSTPPHRRGTRATTEEPSPRRKSRRDDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDJ1</accession>
    <name>A0A401GDJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0214570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611159.1">
        <property type="nucleotide sequence ID" value="XM_027755358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDJ1"/>
    <dbReference type="STRING" id="139825.A0A401GDJ1"/>
    <dbReference type="GeneID" id="38777163"/>
    <dbReference type="InParanoid" id="A0A401GDJ1"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="100" mass="11285" checksum="D45B214C6F690ABA" modified="2019-05-08" version="1">MPKHIYLRDEHFILAVGIDQVTLHAAVDHGSMNTDIVQEVLHVPDLNGNLLSVSQFDHNSYDVQFMDGTCHISNAQGQISTIGYMRRNLYILNVTTHLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDR9</accession>
    <name>A0A401GDR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611220.1">
        <property type="nucleotide sequence ID" value="XM_027755419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDR9"/>
    <dbReference type="GeneID" id="38777224"/>
    <dbReference type="InParanoid" id="A0A401GDR9"/>
    <dbReference type="OrthoDB" id="2685129at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27396" checksum="5BAC109FF0E6D26F" modified="2019-05-08" version="1">MDDYVLFSSSDGYIESDPSTYLSHALVAAVVDDRSFTPLRTLALPFYNDLPPPDYPYTRASSAYSALVQLYARCGQLDTAYTRFARFGDSSLWCQFGCYALETPHHLFVECPMFAPLRENARRDVITESSKLLLGAETTPSLMEDILLVARSLFIDSDVWPLYTSHYFLGILPPTPTQGAPATSTHRRLCVRLMQTWHTIGIRLAGRIWGEYKRRTHPHTRRTFSPPQLSLPLHLAHLLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE94</accession>
    <name>A0A401GE94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611400.1">
        <property type="nucleotide sequence ID" value="XM_027755599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE94"/>
    <dbReference type="GeneID" id="38777404"/>
    <dbReference type="InParanoid" id="A0A401GE94"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="181" mass="19836" checksum="FA999A0F7FB43E4E" modified="2019-05-08" version="1">MARKRKPLPEEIYLDPATKKVRCEACKDNPSPNLPKHRSSSSDWIWRQSLGAHLKAQSHQANVKRWKAARERARIMSKVSYVAAVASTRRARRPAASDAGEQSASEEDGSEGDGEETDQDVDEDGTSGQDTSTQEDSELCFPGVKDANGCVVQDSPDCETEAPVLHVQVEGSRRLADAQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEB9</accession>
    <name>A0A401GEB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0302430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611441.1">
        <property type="nucleotide sequence ID" value="XM_027755640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEB9"/>
    <dbReference type="STRING" id="139825.A0A401GEB9"/>
    <dbReference type="GeneID" id="38777445"/>
    <dbReference type="InParanoid" id="A0A401GEB9"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="583"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="754"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="430"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="583"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE80528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="800" mass="89274" checksum="1DB3254F4C682BB8" modified="2019-05-08" version="1">MSSQLDLYDPLDVIGTGSFGIIRKVRRKSDGVILARKELNFERMSDRDRKQIVSEVNILKELNHEHIVRYHDRHVDREAGILYILMEYCGGGDLSSVIKQAQRHNQPIPEDTVWNYFMQLLLALNHCHHPNGHGRPSTTGSDYEGKERRPQILHRDLKPDNVFLDENNTVKLGDFGLSKALAQASFANTYVGTPYYMSPELMQERAYDSKSDMWSLGCLIYELCALRPPFHEAKTHAELSILIRNGRIPPLPKGYSQSLSSVIKTMLNLNPAMRPSAGQLLGHERLELAFKVSETQKMLNQVKAHKANLQARERDIVAREAAIAEKETRLNALLTEKETRAKALLSQKDEEIATLRSQAANTEAAQLMRIREAVTRRDEELRAMVLKQEAEVAARMARREEEIMEAVRRREEEITQMWIEWETKAREAMSRAVEERMEWVQQRAEELEHERVRLQALDEELQKKIAVLESESTQRAGMSKTKTALQEVKNIMATARLSESPEPISSRALSRYSVLETPTQKVPLLSVETPVPKLLAPPSAMKGVILTATGQPIATPSPAELTKLFIGTPRIRLNFAQVFDYDSEAEDDDGDNNGDESDTCVPSPAHEEHADDTTPQPSPAVRPTRLRRPSMIRASTSRPTVEAAAAAASEPKRSRRSSTRASSSQMSEPASKVHSTSTARAAVVPQPAPEYNLSDEENLPSPFIKKVDRDRISRTVSAPARAAPNVPFPRNAPRRSGPTLRTVAVVNAANAANSASTAGSGRRVSLNKTGIKSVSSTHPRSSIVKAQRASEEARKALIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG70</accession>
    <name>A0A401GG70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0309050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612091.1">
        <property type="nucleotide sequence ID" value="XM_027756290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG70"/>
    <dbReference type="GeneID" id="38778095"/>
    <dbReference type="InParanoid" id="A0A401GG70"/>
    <dbReference type="OrthoDB" id="2743634at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="282" mass="30544" checksum="24908ED91D55CFDE" modified="2019-05-08" version="1">MSATPTTTTLTTTIITTTTNTPTQALPNASKGKMAAVAAAGRKRKLTLMNGEELDLQQVNAIAPVRPEVVEAMKLRIIELEDQLAAKSPAKRARTIAAADVTMELEAGPSTTPASLTKADEKKRKIHLKKIFDRLKKECKAVSCKFQGAPKTIKIEEVFEVDEFNAIFAGKGRLIQPTPENKPKSTVTIMDFNTAQVQVLFGDELKALKGNRWSRGGVPVRTFGAGFGGLGSSFSKSVKQGPCDVEILRLDVNYSKNGMKCTLKFDVGDVGDGSGYDSDEWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGR2</accession>
    <name>A0A401GGR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0310200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612206.1">
        <property type="nucleotide sequence ID" value="XM_027756405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGR2"/>
    <dbReference type="STRING" id="139825.A0A401GGR2"/>
    <dbReference type="GeneID" id="38778210"/>
    <dbReference type="InParanoid" id="A0A401GGR2"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052050">
        <property type="entry name" value="SecEffector_AnkRepeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46586:SF3">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="46225" checksum="0E909CBDAB5FA507" modified="2019-05-08" version="1">MPYYDPSIDLVHDAYRRLSRDQLVLFLKVRSLSTTGTDVELASRLAHYDIHTYHFPSAVNGAGTAPLLSSIDVQSKQRPRQAMAPELPVELLAEIMDHIGDWELAKAVGVPTSLPQPLAWTRASPCDHAILTGYLPLIRAADPASYPPTNIGAKLAVRFGYVHVLEYLLTQHRPIFLSKFKDDLLPITASHHGRTAVLFWWKHAREQYSDALPLPKPSSVADAIDGASRNGQVASLDWWLHSGIPLEYTEAALEMASAKDQLSVLAWWKQQSVVHGLQLKIGRVMDMASTAGHVDVLEWWARSQLEFKYDRQALYHASCHGKVEVLEWWLGSGLQLIFDPDALTGATRHNRPEVLEWWDKSGLPIQYRMCDIEEALEDAIGGGEAAREWWKRKGVDFNANDVEWSKSQNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGU9</accession>
    <name>A0A401GGU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0310820</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612268.1">
        <property type="nucleotide sequence ID" value="XM_027756467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGU9"/>
    <dbReference type="STRING" id="139825.A0A401GGU9"/>
    <dbReference type="GeneID" id="38778272"/>
    <dbReference type="InParanoid" id="A0A401GGU9"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="321"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="386"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="453"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="525"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="820"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="825"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE81355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="913" mass="99165" checksum="922E599608303865" modified="2019-05-08" version="1">MPLNDMVRQRLQPLTAAMTSNRIFLYFVFSVLAVVGAVANACRNHSNFYSVTVYLSRSGRSVLILANFGFILSLLCGRLLQRLFFGPLQAREVERLYDQTWMFVTESLLAFTIFRDDFDIPFVLMFGFLLFVKCFHWLAQDRVESMDQTTYPGPPTLFHIRMVGLFGLLFWTDLLMFVLAVESTYTNGIGGMVLFASEYAILMASVWNATARYTLSVLDFRRARTRGGENAPPWEHKSMYVFYVELATDFLKLTTYLAFFMIILTFYGLPLNIVRDVYLTARSFITRVRALVRYRNATRDMDRRYPNATEADLSETSDRTCIICREEMVVRDTQQPAGAGPAAPAPVQQDGPNMTPKKLPCGHIFHFQCLRSWLERQQSCPTCRRPVLEPDPRNPGQAQARQPGVPQPGAVPQPGQQPVQAAGWLGRILGFVVPQPLVAGPMPHGQWVPVGALPQQQQQQQQQGNFGWAPGQVPPPPPPGYYYPVQYPLPPPQPQQLQPPPVFRGFYGPGGVWQPWVDPQWLAQQQNPQAQAPAQTPQQRPQQSRDTTPISVGEATRPRVSLPGAPPVPTATAPTASAASGSAPAATDRPSTPRDAAATAALPRLNPSGSVTEAPPLAAVSGGPVNSPPVRASVPTPTTTTVSPPSVAASESTSPAISTSTDNAGWPTPQPPHNHDGVSGIPSLLPLYDFGPLTGRAPRPPPNGYPGYLSSAPSPYFRGTGTPSGPQPPQPRTYRPALQQQGGQRTLTRAVVHDPRTPLSQLPATITDAQLARLDRLTREAIDERLRVLEGVSGAVYRCIEELTRVRSVLPISAAVGHAPDQERTATGSATASVSTTTPASGSSGSKTNVETATDVEPPVATKPPRGAPVRLEPSESSEERNDVDPGSQDGDTAVLTGSSPAEDEAIPLDVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHH0</accession>
    <name>A0A401GHH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0400180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612560.1">
        <property type="nucleotide sequence ID" value="XM_027756759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHH0"/>
    <dbReference type="STRING" id="139825.A0A401GHH0"/>
    <dbReference type="GeneID" id="38778564"/>
    <dbReference type="InParanoid" id="A0A401GHH0"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="94"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="357" mass="40735" checksum="3F5872C0D2034120" modified="2019-05-08" version="1">MSNKLPAASLSQTSSPRISTLGPGASSCGVENSDTTVSRKAWNDEEFFAKVAHFREEALEIHLNKFRVWKTISRNYLPLFRQDVHVWYGDAPYYVRIVDVPGALSGDILRYKADLPRYDCHLEVVGDTVREIDFKPYPPEELEEEGNPNVLEDDAKELFATLPLVTFDEDKHFTKPARTRREIEVLQMCKGLPQFVQLLGRLEDDQLVFPKYPHDLLLAAMSHKSIDAIRKWMLDIIDGIAFLHARGVTYRDFVPRNFLYGAPVVICDLECQLASRICKAPEVLAWDDPPDTVFAPASDTYGLGILLQLLCYANNPRSPYVHWPVLPPFDKIYEACTQTRPEDRPSLVQLKAWLQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHM7</accession>
    <name>A0A401GHM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dual specificity phosphatase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0313520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612536.1">
        <property type="nucleotide sequence ID" value="XM_027756735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHM7"/>
    <dbReference type="STRING" id="139825.A0A401GHM7"/>
    <dbReference type="GeneID" id="38778540"/>
    <dbReference type="InParanoid" id="A0A401GHM7"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dual specificity phosphatase catalytic" evidence="7">
        <location>
            <begin position="86"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="177" mass="19604" checksum="C692FA961FBA59BE" modified="2019-05-08" version="1">MKATIPTDRRTQLMYSKFAARTPSPLRSEIMPGEEPQKPSTRRTHSKSSARSEQRKSRATSTRTSSLDDYQPHACEIVPGFLVSDTHTATSPEILDELGVTHMISLMRDGEPSYTPDINHVCIPIDVTAQSKLIQSFDCAVVWIATAMRARGTVLVHCMWGTSRTTRSPSSDRGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHY8</accession>
    <name>A0A401GHY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0401790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612719.1">
        <property type="nucleotide sequence ID" value="XM_027756918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHY8"/>
    <dbReference type="FunCoup" id="A0A401GHY8">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHY8"/>
    <dbReference type="GeneID" id="38778723"/>
    <dbReference type="InParanoid" id="A0A401GHY8"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="127"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="249"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE81806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="392" mass="42436" checksum="C8B315BC0F0CCAA2" modified="2019-05-08" version="1">MSSNGTATVALAPGHFLFTSESVGEGHPDKICDQVSDAILDACLAQDPFSKVGCETAAKTGMIMVFGEITTKGTIDYQKVIRDTIKRIGYDDSAKGFDYKTCNILVAIEQQSPDIAQGLDHGSLESIGAGDQGIMFGYATDETPEYMPLTLVLAHKLNSAMAAARRSGELGWLRPDSKTQVTVEYRKEGGATIPLRVDTVVVSTQHAAEISTEDLRKELMEKIIKKTIPANLLDERTVYHIQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDWSKVDRSAAYTARWIAKSLVAGGLARRVLVQLSYAIGVAEPLSIYVDTYGTGKKTNEELVEVIRNNFDLRPGLIVQALGLQKPQYLKTASYGHFGNSEYAWEQPKKLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI44</accession>
    <name>A0A401GI44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0401540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612694.1">
        <property type="nucleotide sequence ID" value="XM_027756893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI44"/>
    <dbReference type="STRING" id="139825.A0A401GI44"/>
    <dbReference type="GeneID" id="38778698"/>
    <dbReference type="InParanoid" id="A0A401GI44"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45663:SF11">
        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="10"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="15708" checksum="B5DE20608A2D70BE" modified="2019-05-08" version="1">MSALALRTLAKTLRPSEVSSLRTFHWSARRNKHFLNANEATFEEAITNKDNVVLVDFYADWCGPCKMLSPILEKLTTDPSIKSGSGLPLDLVTVDTDTETALALKYKIRSLPTVIAFKDGQPISQFMGAVPEAHVRNFLTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIC5</accession>
    <name>A0A401GIC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0402570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612796.1">
        <property type="nucleotide sequence ID" value="XM_027756995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIC5"/>
    <dbReference type="GeneID" id="38778800"/>
    <dbReference type="InParanoid" id="A0A401GIC5"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="653" mass="71822" checksum="D9138DF3CD7C0C36" modified="2019-05-08" version="1">MLSTNSDETLKHLRDASIGFDHLFSNDLEKAREIFATGSSPFHALGLGVCAFLEAALGMETGLLVEAARCLALSEAGSKKQFKSSKGSGSNTQFPPGIEWELLHSDAIILLGLNHALSESYMGYLQCFAHSKYSRLYKAVYPAGLYEYTTPGSSPSPSVYSSASSTSVSTFTGSTPNTPKSPAKSTFFGRWGKSSLSVPSTASVVIAEEGSVDELILSGTAFGFGLFNLVFSLLPAKIRGVVGFLGFNHDRKLALQALAVSARRTDAHSVFAGLALMTYHGVVLLLAGYQADEAHIIKQYRAIVENIASRYPNGSLWILNRAKILRMTYDPEGAIAILQEGLQPNRPHTFSQADGLLIFELAWTLLSQRRYKEAAEMFIRMTKVNSWSHGTYYFIAAGCYVSLKDYDKAQELLDEIPVLLEKKKITGKDLPTEVFIKKKLAFYREKQKRWTGSEEHFARCIRVSPAEELGIFWNTHARILKETAEAHIAELAVLVPHPTITSPYVTAPTSPPATAACVDIDTPDEFAIRSLLLGITHRTAGAYEPARAFLSDAYSRQSSIKVSTWVGGVTLFELAVLELKETEARTERDTVTEMMTEEESRKEWARALKVASEHLEAALALATQQVDLSSRLDSRIAMLKDEIGLKREMLFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIF0</accession>
    <name>A0A401GIF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0403120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612851.1">
        <property type="nucleotide sequence ID" value="XM_027757050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIF0"/>
    <dbReference type="FunCoup" id="A0A401GIF0">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIF0"/>
    <dbReference type="GeneID" id="38778855"/>
    <dbReference type="InParanoid" id="A0A401GIF0"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="10">
        <location>
            <begin position="89"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="9">
        <location>
            <begin position="602"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE81938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1194" mass="134362" checksum="F2889C68C8C7D7EB" modified="2019-05-08" version="1">MATFSPSPAPRPAAQRTSISHALSPPRQPVRRTRTGGSKPASRFATPARQERQSSVDGSLTSGMDVDDTLDTYERPLKAETLFAKSEELTATFYASLPVEVKHVLKNTDFYRNAYSGDIDTETGFALVASVETCFVWKYAQALSGTPTCYIFVCPRDDYSPPMTTVFHALVPYGASREPGLILVSYFGGVRFWDSIGMGLTGGETYSWSALDLQEDECVTTLTRSDPQTYIISTSAGRLYLLMLTKTGGKYHLTNRVFSRQQSALSFSRLWPNFLTPPSIFPDAGNINSIALGISNKTESARDVWAVIETRVQKWRMHIEGWEELLLDDDLGDAIRTAIREAFVSASQPDMDLDLELLDLKLESPSNLVILVSYAAQEDDEMETLTHPRRIYAIIHVRYGGKSFQVEKAQAVPYQSTARSGAPMHPRLQLMLGGQLVAIQFGDAVTICARDNDYMDRLALKSKRDRTLGVGVVEGNTELLILTAGTTMKAYIDMDQVARFDAETGRANLIKWTMTQAILYGSYPENPLEFSFPPEIDEEALMSGAEQLSQAIIQSDSDVVRPNHDLQAQIAGRKERLSWLIKFINDNVALPKMSQHSRQRLATDAEKLYAADQLWLQHSEFLGVARRNNVLSEAIYRYMNAVGESHHEDCVRAFFRLKVEDIGSVFPHLLQIVRNAAQGGRSLAVELEQANRIILTVLQSAINYREFNMGVYGVERPLIDLWSSKPALIDIISELFDTTARLVESPSPDSAAAQAKSGPRGQLPQLATSLFASIQERLEWLESPLAVEGGSARELTNLDSTFRQLRPEVLETLRRNGFADHAFRLAEDYRDFRSLASLCHKETVYPPQDNPNVARIQSYIGKFKEDFTNELYQWYIEHGELRTMFAQDHDEYLDTFFEEHKYPGISWIHDIGKGRYDAASESLLSEAGHSSDLMSKHLMLSIGKLSHLAQSQADATPVDQSLLDAFHVGLDFVDVHETLVDDLKSALATVRNRQSLEMQVETITNVKASQLDERRSLQNVFKQFVRQLLQGKALSPEDIADLLSLKDNLYSVEDYATALQLLSRAKGMPEARRFAAFKSVWRRIYIHDDWDAIRQTSNVTDAELNQRLRNTALYVALRSTLRKRHPPHGYILLPLEVVEIPDRTEISLRWPGMSPDEVEGVERDYRWESDCLIRLELDGMSDGMRTLVAEELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK03</accession>
    <name>A0A401GK03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0408790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613408.1">
        <property type="nucleotide sequence ID" value="XM_027757607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK03"/>
    <dbReference type="STRING" id="139825.A0A401GK03"/>
    <dbReference type="GeneID" id="38779412"/>
    <dbReference type="InParanoid" id="A0A401GK03"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="660" mass="75820" checksum="391261D4BE2AA668" modified="2019-05-08" version="1">MSPKKAKARKAAPANSVSEGVPAPQPAELAARRSLRGKRGGLKDMPNMPLDIILEIISHLNPRDLLNLARTSKAFRALLMARSSAYLWKATRKNVEGLPDCPPYLSEPEYANLAFFPYCHSCLKTNIQNVIWEFNVRYCNDCKKENTTESMFGLPLGLMRKIPCNLDALNRISGRRYLYLFHLPQIDAFVKSWLAVVDDEEAEKKVIQQQIERVDQIKEHSRLCNEWTKSRVRSRASELDDVRRARLESIVSRLRDLGWGEELDFLAPKQYFPLSNHAHARPAKPLTDRGWQKIRDDVISYMEELKTLRLAKERRERLQSRLPLLSDLINNYYSGIPRTPASEYLPHLVDFAMMSEFRTLVDADGSVNITAEDFLALRPQIPKFVQDWQNRATAQLALLLVKELDIAAIPDNTTIFDLAVAWFQCTKCHAVFRYPNVIAHGCMRQYYHGFCYSDAAHEYQALVYWEEHTTAWSTRSISCILPVRRARMLVEACGKDPDSTTEQTMDELDARFWWKNPIASSSRKVVSWRLAMKPKWTRMYPGGTPEREWEVVPGNVAEKVKDVEAQSHITRLFQHELRSHWCCSLCNESGGRNCSLSQAKEHVRNLHSIDDATVENGRIYLHPDSKPLIPKSVIALKRDYCGRDETDLLHEGLACVCDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK55</accession>
    <name>A0A401GK55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DOA4-independent degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0409350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613464.1">
        <property type="nucleotide sequence ID" value="XM_027757663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK55"/>
    <dbReference type="FunCoup" id="A0A401GK55">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK55"/>
    <dbReference type="GeneID" id="38779468"/>
    <dbReference type="InParanoid" id="A0A401GK55"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="247" mass="27473" checksum="35D5C2150431C635" modified="2019-05-08" version="1">MNIIETLFGRTITPAERLRQHQRALAKAQRELDRERTKLEQQEKKLVMDIKKSAKAGQLNACKVMAKDLVRTRRYVHKFYQMRTQLQAVGLRIQTLRSNQQMAEAMRGATRAMGAMNRGLNLPQIRRIMNEFERESATMDMKEEMMSDAVDDVMDEGIEDEEEEGDKILKQVLDEIGVDLSQQLAEAPSGLAVSSPLTEARQAVALGESGPAHHTGGSNNQGGDDSPGGGLSDEDALQARLDALRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKW1</accession>
    <name>A0A401GKW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0411940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613721.1">
        <property type="nucleotide sequence ID" value="XM_027757920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKW1"/>
    <dbReference type="STRING" id="139825.A0A401GKW1"/>
    <dbReference type="GeneID" id="38779725"/>
    <dbReference type="InParanoid" id="A0A401GKW1"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="303"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="528" mass="57600" checksum="C9100291F7EE3745" modified="2019-05-08" version="1">MSFTPVIPPYPSPSGGASPEPPRSMPAFSQTQPSPAPAWAQQSSFAGSSPYSGSMPMSAPGSYLVPPVALPQSSHTPVAPVGPSGFSPDWVGFPYNPAANLSPYQGMMQPGMMHPGMMHPGMMQPPPPQQQQQQQPPPPLQQQQQQGYPPPQYAAAAGGPIHPQTAYMYAQQLPPQFQAGYPTPAPPMYAMPGMATPYATPYAMPGAWGTPFPAAAGGLPPQGAIPPQGMHMPAAATSAPAAHTRGRIFRPQDMSVYDKVDKFAEGDHYGAVLDPFVLKRVHARVEVNPLLQPPPENLDRAYLKWNMLFPTGQCQRSTDPPSRSWHVGRHAPATWPRLTSLRLISRSLPWPIEVTASNPFLGVTCGEVIETIQQYMYEKVSEAYYRTVSGTRKRMLGEAFYYNRSTADGVPGGRLPHMLLHCDWLGKNTTFGGIVHDEQLVHELCGAALPAVFELRCVESWPVSEEEQREMEARELEADERLRRRGRSRATSRAATSRTTSQAPSRATSRATSRSRATTVEDVTDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL15</accession>
    <name>A0A401GL15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase 2C homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0412500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613776.1">
        <property type="nucleotide sequence ID" value="XM_027757975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL15"/>
    <dbReference type="FunCoup" id="A0A401GL15">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GL15"/>
    <dbReference type="GeneID" id="38779780"/>
    <dbReference type="InParanoid" id="A0A401GL15"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="115"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="493" mass="54924" checksum="D3761FF74A4629B4" modified="2019-05-08" version="1">MLPRARLNVFAQFIRPRSSVLFSRLHLGALHAGGALLLSLWGFTYALTPPKVYLDGRKTSDQLGAPEQYEQYEPLPFQRQKPLDRFRERSRIDVDEELRRHEQTHLPERGSGIARYDIAQLASNDPIEDDHAEAILPVPSGHWSFFAILDGHNGWETSAWLRDNLIPAVAGALADLFNNFSSSLTPGTEPDPPPDDIEDTIQATFKRLDDDIVYNAVERVFETNSRHAGVTLLAPAYAGSCALLAFYDDHTRVLRIAVTGDSRAVLGRPAFDERGQAIYEVCVLSVEQDAHNVAEEYRLNAQHPGEAVVANGRVLGMGPSRAFGDARHKWSRRVQERLKEAFLGRTPPRDVRTPPYLTAVPEVTSIRAQPGDFLILATDGLWESLTSAEAVGLVGLWQDGHTKEGEAPREMAPVPPSELPVEVHPEDEEETVRYRQWCAEKRFVNCDQNPATHLVRNALGGADSDLAAALMSMRSPRARVYRDDISAVVVFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL90</accession>
    <name>A0A401GL90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0413280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613854.1">
        <property type="nucleotide sequence ID" value="XM_027758053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL90"/>
    <dbReference type="GeneID" id="38779858"/>
    <dbReference type="InParanoid" id="A0A401GL90"/>
    <dbReference type="OrthoDB" id="2739948at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="316"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="748" mass="86436" checksum="CC49B5DBE33EA01C" modified="2019-05-08" version="1">MATHISQNAQPSKQQSSEFAMQVPFAAVSLKTFLAEFMPQPDVATRRRDKDFKHMFDKMPANNNSEDDFYHTLIQCFCEQNICPNYSAGRITKSEMVDDHAALFLTNDKKSIIWNRHWALQCLAIICKPHYHDDDPFAENAKSDKRNADCRKTTRDLLTTIASKVFSRQHRCFFFTVLILGDSARLLRWDRSGVVITEPFWYKRTPHLGSFLWRFAHLSPVQQGCDSSAEVVQRGSVDAKLIEKFTAERPSTMNEYVHVMFCNSMKDESWLWWKLRIVPEVNESALEGPEQRSGSKKRTRGDHLSGPSTKRRRYAGGRAISNDSNDERRARYFLVGKPHFHSSSLPGRGTRGYIALDCEEEVPVFLKDTWRCDPLPMIREGCVLRALNEAHVENVPTLVCHGDIENQCTRTQDLRKNVSAGQKDNSPRNLIHYRMVEREICRPLRDYETDKQFLHLVADCLKAHEQAVERVGVMHADISLGNMLIFEQYRLDQNEEGCFRRVGMLCDWEFSKPVHTTRNGEKVAQRAPTDVCTWEMAGVHLADHPGTPITIPDELEAFFHLILMVTVRDQRSNLGSNEWAFRKDYFVDCTENPKPGERYMTCTKLKRKAMYEGKIMYKATPLRIFRSADDKRIHPFGDLLSMLLTLFRAHYSATLYDEWHNRPKRRLRSNTGQHVVEPPSCIIRLEPDELVRRRELAAGLKSHCAMQDLILLIAEGDWLGSKKRDCEIDQGKEDIDIPHMIFTCEAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLN6</accession>
    <name>A0A401GLN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ysc84 actin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613995.1">
        <property type="nucleotide sequence ID" value="XM_027758194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLN6"/>
    <dbReference type="STRING" id="139825.A0A401GLN6"/>
    <dbReference type="GeneID" id="38779999"/>
    <dbReference type="InParanoid" id="A0A401GLN6"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF7">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="1">
        <location>
            <begin position="121"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="279" mass="28565" checksum="447D9D9EBE2F940A" modified="2019-05-08" version="1">MSMFDKFKRGAQRAGAQASTFINAGSTTIASGSRDFVQGFSLPGEADKAAKILASFLADPENPESALNSIPKVVLQRARGLAVFSIIKAGFVFSGKAGSGLVIARLPDGSWSAPSCIATGGVGWGLQIGADLTEFVIVLNSDDAVRAFSMGGNLTIGGNISAAAGPIGTGGSIQASLAHPAPMFSYSKSKGLFAGLSLEGTALIERKDANRDFYGSPVPARDILSGHVPPPEVASKLYEVIEAAEGVDEAGLPETAYVPTASGDHMEVRGGGTVFDAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLV2</accession>
    <name>A0A401GLV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614032.1">
        <property type="nucleotide sequence ID" value="XM_027758231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLV2"/>
    <dbReference type="STRING" id="139825.A0A401GLV2"/>
    <dbReference type="GeneID" id="38780036"/>
    <dbReference type="InParanoid" id="A0A401GLV2"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="278" mass="31798" checksum="2ABDC1EE4AE1094F" modified="2019-05-08" version="1">MATAAVLAPHDVPTTLNYYKAIGNEPAYQYVSSPPEGKPRNNLDNDSHPAVIHDLRGKEDTVSLDTTGFQFVNYPSAEKEFVDEEAITTKYYAEVEDLLKKFTGGKRVFIFDHTIRRKPQDNPDRDGLARGPVERVHIDQTFQASINRVHYHLGDEAERLLQGRVRIINVWRPIGAPVAHKPLAVSDWRKLDLNDLVPTRLIYPHREGSTFSVRYNPNHRWHYLSGQTPDEVLLIKCYDSFEDRARLTPHTAFTDKSSPPEAPTRESIEVRVLVFDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM68</accession>
    <name>A0A401GM68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0503550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027758419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM68"/>
    <dbReference type="STRING" id="139825.A0A401GM68"/>
    <dbReference type="GeneID" id="38780224"/>
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    <dbReference type="OrthoDB" id="3268221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="589"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="710"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="749" mass="82990" checksum="92C8C2103396ECA2" modified="2019-05-08" version="1">MFTTTRLLEEQDRLKDYPFPTMDTVEPSSSASDSPPYRSRSLRSHSQQSSVSPPPRPSRSRVDRDRDREREYLGSRSKLFSRLISREERDASRLRSVLVRTTDRLEEETRRADEAERRVLDTLHKLRAAREETMIAQASAARANEELRLYRSRLDEAQREIHRGQQIIDDLEQARVDAEAEAARARTIARRFREEHLVAKALEEGRRQGYQEGFSRGKDLASYEKRTSERADQRRYTRQKPIESISEEDDVEDDGQYSRRSLIVAPVARTPMQPSWQAPSRQSSSRASRRSPPRLSDIAPITSSTPVRSVITPLRTPSPSRVHLKTPDPTPIPDPSVTQPRRDTPITPIPMNQPPPSPVHPDYDIPPDNWIPYLNEQTGMFIPPPHELSRPVSPHSPSPSLPDPADPPRAAAVEQPVRARDYAYSQPVERLPVSLPGHHTTMSPQSRTSTNISQYDIVNARGEGAAGGHRNPHEALAGLHQVIDASMAFNPGVERSKTPATAREDRQASPRGSRHREDGRARTPGPSPGGSRDRDANENQGSRSPLERLFKLRYRNRRSPGSSGVPDIFVESPSTGPSASTSHVGQTAGQEGFLSPEYTPRPLSAPEDIAVRDSTPADQRPLPPLPEIGLTSADMAFPLDQLPPGFLATSFTPQVKPSDIPAQYEPEITSTPHHQRPPRTPRSLYAEAPVPADVVYPDPPGKIRSPHTGAARPLTPSATPSSPPARSGSGSQSGVLSPLSLRLGSPLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ57</accession>
    <name>A0A401GQ57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0603360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A401GQ57"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="686"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
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            <end position="577"/>
        </location>
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        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE84357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="720" mass="76974" checksum="6096B1EFEFBF26D0" modified="2019-05-08" version="1">MSSDKSDKVAYRFYTKLILVVNHARATVQPTAQARGDIWFNLETPDTELFKEHTRIYRSVSSAHSLPPFRLQVLLVVPELTNNQVLVYLAPDSSRVRIDPTPRYILLESWDIIFTQNDSQHRYGADVALPTMYKQAIPLFRSVFTLLRILPAWKLSRRLRTRVGGNRNGNFSIQLRVQGIDEDRGAEGILGFDTPLAQTSPRLSKDSHDFTPVTHPVGTLSLSVTYLTSPNFQLDELESLLSSRFLSLDEGPDFTPTLVKNQQRDSLSGSPGSLPVRMSLPRSPPSSVADRFVVPPSMHSRTTSLSGLSGLGGSSPRSQNVGLLPMRRLSNTGAAGSTSAVSDASSSRQGAASTGSRDDIPPVSALAARLRKESLGTGRGSDFIPSPGPVPIRRPINPVNPFKSSTLSSGSPSLHSPSPSLRQHSPLSSGGPSLPSRPAHTSPTSSRAHVPQRSGSKAPPSPVPLPRSSPPYAPSSLGGRSLTSVEGVILEGSPRLTGKRYSSSFGHRYAATGGVGSEGSAGSGAKEGERVASPSFLSTNTDDDDISAFVQDIDARKPLGGLREQSASSSPARSPHSPDIPEGPHETLPSVVQRTRSLSLNEPMLTTESAVDERLRQMNETFMASLQGLGGRRRERGDSIRARGGSTHTRSPVNPVDVGSEGGPERVGINVDAARVPPAYVRPRFASTGSARSGMSVASGEVLGRMDPEVEDDAQSDPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQG7</accession>
    <name>A0A401GQG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0510530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027759106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQG7"/>
    <dbReference type="GeneID" id="38780911"/>
    <dbReference type="InParanoid" id="A0A401GQG7"/>
    <dbReference type="OrthoDB" id="2677684at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="291" mass="32134" checksum="42690D1CF0E25C28" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQPPEPAIHLIKMSNLSPMPLTDQIAGVLELMFRRKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPVRLQWDINRYCDSLSIQPTGQNEVLEAELERKWPPPFGESEIHIDQPATLVDMHGRILAWILPKVLIPDRQTKMLQATRALHPAIAASKPSSTTASWRHNPLYFLPPEECVQFPAGSLCLLPGWFQQVREHMESGRLETSTSLKLEGGRSWLRDIHDSSALLGTILAVVHPTLYAAGRQCLGLIQQDPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQH4</accession>
    <name>A0A401GQH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0603880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615322.1">
        <property type="nucleotide sequence ID" value="XM_027759521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQH4"/>
    <dbReference type="FunCoup" id="A0A401GQH4">
        <property type="interactions" value="603"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQH4"/>
    <dbReference type="GeneID" id="38781326"/>
    <dbReference type="InParanoid" id="A0A401GQH4"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="419" mass="46674" checksum="02052973B96F75CE" modified="2019-05-08" version="1">MSFTLGSILNSQISLVQEASEALPHQFSQCTYSLGPRRQAVYLCKTCGETRGICSACSIACHTDHEQVELFPKRNFRCDCPTSAFALQCTLHRTLEPENGKNVYGQNFLGKFCRCGREYDAQQERETMIQCLACEDWFHESCLNLRERPPSRDPSPEPTQESPDEDDAASEASSSGLPPPLISASDYDSFVCGACVHKIDTLKRYAGTSKVLMVVRDSPSDKWRIIGDEDAGSSTVEVDIAEPGSSAGEKRAHSPTKPDAPDAKRARLSPVPLSSQPCLAPAMNPRAQELLSSQESRDDEGLQAFSPLGCGDVFLTEGWRERWCRCDACLPSLRAHQYLLEEEETYEPPEDPDSGLSLEELGLRALQRLPRDRAIDGIRAFNEMRDDLMNHLRPFAQEGKVVTERDIRAFFDSRTEPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQI9</accession>
    <name>A0A401GQI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">SCP_0604510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQI9"/>
    <dbReference type="STRING" id="139825.A0A401GQI9"/>
    <dbReference type="InParanoid" id="A0A401GQI9"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000131">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF3">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE84472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19827" checksum="1413B4B9578F843A" modified="2019-05-08" version="1">MPIAPPLNFPKWLKDNGERLQPPVNNFCLYSGHDFIVMAVGGPNERNDYHVNETEEWFYQHKGGMLLRVVDGDEFRDIRIGEGEMFLLPANTPHNPVRFADTIGLVVERVRPDDATDRLRWYCKAPVHAKPTIIREEKLHVTDLGTQLKPIIQHWMSDPAARKCAECGAVAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQL0</accession>
    <name>A0A401GQL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0605100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615444.1">
        <property type="nucleotide sequence ID" value="XM_027759643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQL0"/>
    <dbReference type="STRING" id="139825.A0A401GQL0"/>
    <dbReference type="GeneID" id="38781448"/>
    <dbReference type="InParanoid" id="A0A401GQL0"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018975405" description="LysM domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="27"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="198" mass="20107" checksum="5D70EDCC1A16714C" modified="2019-05-08" version="1">MFSTAAFLALAALPFLASSAFAQTCDRSYTVQAGDICDSISAANNVSTYQLAACNPSIDATCDNLYAGEVLCLGYQGEDCNTTYVVKLGDDCAAISTAYSINTTVLYENNPQIDAACDNLYVGEVLCVAGTETVVPPPSGSVVPTTIPATATPASATPTAAPAATTPAPSPSPSDDGSDDGTDDGDGDDSNLPYCDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQM0</accession>
    <name>A0A401GQM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0605200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615454.1">
        <property type="nucleotide sequence ID" value="XM_027759653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQM0"/>
    <dbReference type="GeneID" id="38781458"/>
    <dbReference type="InParanoid" id="A0A401GQM0"/>
    <dbReference type="OrthoDB" id="3263183at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="37383" checksum="65952B1F3B7F3E36" modified="2019-05-08" version="1">MNELQDPSDLTTRLKGWHSIGEVIQSGSIFNTCTVALGCTTTVLTRGATVRFHEAILVAMTNLLLNPKAQDGYMMPLRSFDKDIRECQEPGAYDKYRLVKVTHYKDVTVIAHEFLVLDIYNSEEVSEGVIHLRIERGATTVKPGEGFSASSKNTLAYVRLTNDKISRDPLFQPSKYFRIAYLRCPPTTIISLPDVCRIFPTLYEGAPNYSLLKNQCYWFCSTFLHGVETDYNLRRIKAEYWMLRGNPGGWLGNLIKLFKLRILRDNRAKEDTDAYIQHGVDEETKAKAAGKAKLDRSLAELVTQQKQKNVGDRDMVNRLLQPSPIGRASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSK3</accession>
    <name>A0A401GSK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0703590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616086.1">
        <property type="nucleotide sequence ID" value="XM_027760285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSK3"/>
    <dbReference type="STRING" id="139825.A0A401GSK3"/>
    <dbReference type="GeneID" id="38782090"/>
    <dbReference type="InParanoid" id="A0A401GSK3"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF4">
        <property type="entry name" value="BLR3030 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="487" mass="52760" checksum="CF1F6D6CC74F8B4E" modified="2019-05-08" version="1">MTNPVEAVRYLWESASLPSQALSRLVLSEDPDPSVNSSFKLGSAALASQVHSVKSAIALSEQTVAVDARHAVLEFRSEAWYIVNGRLPSGSLFDDLAGLYKTKDNSYVRLHTNFPHHRQGILDILRCEPTKEAVANALLQWNAVDFETEASSRKMVATAVRSFAEWDEHPQGRALANTLPVQLIKVADAPRRKIAGTHGHPLDGIRVLELTRVLAGPVCGRTLAGHGADVLWITSPSLTALPLLDIETSRGKRTTQLDLASLEDRQTLAGLVKEADIYLQAYRPGSLHDKGFGVDNVMTGHPGVVYASLNAYGWEGPWKDRRGFESLVQTATGFNLGEAEAHASYAGEDSAHVIPRAFPMQALDHAAGYLLAFGINAALCKTITEGGSWEVRVSLAAVGQWIRSLGRLDPMVAFGVGRPFPPHTLPQDPEITVLATAVIQLASDKPAIEHHDMTAIRHAAILSKTPVMEGQAPMGLNVHEPVWLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSN9</accession>
    <name>A0A401GSN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD/NADP-dependent indole-3-acetaldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0703760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616103.1">
        <property type="nucleotide sequence ID" value="XM_027760302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSN9"/>
    <dbReference type="FunCoup" id="A0A401GSN9">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSN9"/>
    <dbReference type="GeneID" id="38782107"/>
    <dbReference type="InParanoid" id="A0A401GSN9"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33514" checksum="E2C034D4E407D155" modified="2019-05-08" version="1">MPFESVTLNDGNEMPTIAFGSGSKWKSHDVTDYVIQAIETGFSHIDAAQAYGNQDSVGAAIHESGLSRSELFITSKWSRDTTPISEALQESLTQLGVKQLDLYLIHQPAIVKNVEEAWGTFEKLKEDGLVKSIGVSNYELDDLQKLIKVAKVKPAVNQIYFHPYNYTENKALLDYCTSQGIVVEAYSSLAPITRYPGGPVDKPVAAAAKRLGVTPTQVILAWVKAKGLTIVTTSSSKEHLEEYLAVGDLPPLTEEEIAAIDEAGANAPATLFGYQLPIRIEIGPALCALCVMGVGKLAWRAFTRYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSR8</accession>
    <name>A0A401GSR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0704590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616185.1">
        <property type="nucleotide sequence ID" value="XM_027760384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSR8"/>
    <dbReference type="STRING" id="139825.A0A401GSR8"/>
    <dbReference type="GeneID" id="38782189"/>
    <dbReference type="InParanoid" id="A0A401GSR8"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="100"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="218" mass="23495" checksum="99F6EA9875EAF987" modified="2019-05-08" version="1">MATAPIARASVPPRSPRDPRSPSPPPSVPDPVPAPRHSPTPAPQSRAQSLAPTSTSDDADNEAEQPVTEPATEPATEPDAQSTIDIETFHQILDLDEDDTHDFSRGMAWAYFSQASTTFTEMDEAFSAKDLPKLSSLGHFLKGSSAALGVSKVQASCEQIQHYGQLRDEEHAIDLQPPAALALIGPLLSRVKSEYATAEAWLKKWYEDHGGLGEEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT14</accession>
    <name>A0A401GT14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705650</name>
        <name evidence="2" type="ORF">SCP_0705730</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616291.1">
        <property type="nucleotide sequence ID" value="XM_027760490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT14"/>
    <dbReference type="STRING" id="139825.A0A401GT14"/>
    <dbReference type="GeneID" id="38782295"/>
    <dbReference type="InParanoid" id="A0A401GT14"/>
    <dbReference type="OrthoDB" id="3251176at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="230" mass="25693" checksum="A8C39CA8EC7BE84D" modified="2019-05-08" version="1">MLGKIANVIGTRIPPAPPHVQTLPVCHAPILVPSRPVVNIQQPTIPWNPSSAPLYASNLTPLPAPSATPQAALSQNCKVVNLGGEDFAFDKTQVPDPPSIHFSDDIPRLFREWHSSTVLRIPINTGCSIPIKYWDLFYKKKSSVPGKEKAWGRVRMKWGNWKFIVEERDELGSDDAFWDVYSNENGERLRYQQILDKLKARRADRSACNAAAARSYFDGNLERADANGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT48</accession>
    <name>A0A401GT48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">54S ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0700950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615827.1">
        <property type="nucleotide sequence ID" value="XM_027760026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT48"/>
    <dbReference type="FunCoup" id="A0A401GT48">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GT48"/>
    <dbReference type="GeneID" id="38781831"/>
    <dbReference type="InParanoid" id="A0A401GT48"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="136"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="213" mass="23201" checksum="C6A631FA2992B528" modified="2019-05-08" version="1">MVLRPRVVPAVRLFSSSASAHGLISNIGRQPIRFPPTVTLTPTPTAVDVTGPLGTTSVPTMPYMRFTFPAPDTLSVAVEDGSEKKQRQMWGTTRTLIANAIEGMTSGFSVMLYLVGVGYRAALEPDPRGPGEGRSGQRIAMKVGFSHSVYVSVPPNIKAEVPAPTKISLYCTDKQLLGKFAAQVKRWRPPEPYKGKGIYVGTERVRLKTMKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT76</accession>
    <name>A0A401GT76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0706190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616345.1">
        <property type="nucleotide sequence ID" value="XM_027760544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT76"/>
    <dbReference type="STRING" id="139825.A0A401GT76"/>
    <dbReference type="GeneID" id="38782349"/>
    <dbReference type="InParanoid" id="A0A401GT76"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="303" mass="34503" checksum="94333B2E80510D7E" modified="2019-05-08" version="1">MNPTFCEDSIMLMIDHVIDATRREDGVLVSIKTVERDSEEVRIASYLSRPEVSSHHLNHCVHVLDIFPDPFDHNAAFMVMPYLRPFNNPEFGAIGEVTEFVRQTLEGLCFLHGQGVAHRDCAAANIMMDGTPLYPQGHHPVRRESSPDGIYLLSPLSRIDHPVRYYLIDFGISSLFGKGESPYVVGRKGRDKELPELSDDVPYDAYKVDIFILGNLFKKDFLQKYYGLEFLGPLVKAMTARDPAHRPDAEVALSIYHDIRRGLDPSLLRWRLRPRDESAPERILYDSVAVAREGIYRLKHIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT83</accession>
    <name>A0A401GT83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0701260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615857.1">
        <property type="nucleotide sequence ID" value="XM_027760056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT83"/>
    <dbReference type="STRING" id="139825.A0A401GT83"/>
    <dbReference type="GeneID" id="38781861"/>
    <dbReference type="InParanoid" id="A0A401GT83"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016814">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052349">
        <property type="entry name" value="Metallo-hydrolase_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32027:SF0">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="491" mass="54157" checksum="3A2CAD300E2C6F5F" modified="2019-05-08" version="1">MPQRSNQLVMMSGRDGDEGLNRRLVIHNVHLDLDDDGHAGTELYDVVCVDGIVDTISPAGCKDTEFTDLADSPDRCDLEQLDAEGRGILLPALCHGHIHLDKCFLLDKCDDLVSGDFTEALKVTAKAKSAFPADTEDLYDRGKRLITESVECGVTLMRAHVEVDRTVNMCCLEAGLRLREEFQDICDVQIAAFAQDPLFASLDDEHPGRNLDLLRNASRRAGVQAVGSAPYVEPSTEHAKRNIKLILDTAIENRLHVDFHLDYNVDLTSEPLIWYVLEQLHERIRSGRWHAGAHVCIGHATRLTLFSADEWTRFCQLVCENDLPVTLVGLPPSDLYMMGRNLPQAPRSTLNVPKLAREYGLKIGMSVNNIENAFTPQGPLDPLALCPLGVAIFQAGTRQDCRTLLEAVTLNTRTAIGHATMSPLTGESTSTCGLVPTIGNVADFVLLHDNETAYSAALNPSYSRTTIKAGVIVSRRLAKKWLREKKTVQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTT3</accession>
    <name>A0A401GTT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0801600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616554.1">
        <property type="nucleotide sequence ID" value="XM_027760753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTT3"/>
    <dbReference type="STRING" id="139825.A0A401GTT3"/>
    <dbReference type="GeneID" id="38782558"/>
    <dbReference type="InParanoid" id="A0A401GTT3"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="39"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="549" mass="59463" checksum="3A5A2E1112CD24F3" modified="2019-05-08" version="1">MARLRRDTPDLGVPPVQRPLRIVASGTLFLTHTLLLPTHPEPNAITRAQSVNRSRGGSASTCLTILAQFPAVEAMLVAPLGGNEEGQMIIRDLQNERVSTRFCKVCKHAGVPSAWVLHAGDTDSRTVINNNPLPDITHEEFVSLLGPLLAPENYAYVAPPSSHTPGLSTTPPANLTVNSSMQPRSSISTPLPSTLTTGRVGTTTPAPFDWIHFEGRSVKTTLGNIIGLDGLARERKWRSHCVFSVDIGRRARQGVEALIPHADVLFLNKHYALAHSPQYASSPRAFLLSFIALAPPHALLVAHWGAEGAAVLSMPTKEYFQSSGWVEKNAPRFGSPTTGMARGIPENPDVVRDQVDMRSVRTGSDFYADAGHTIDTASMFTAGGLSSALASEHPREEPPQRARAASAVRQQQRRRRDGRGEDDGESSDSDGTQIAGPGATHEGGVPRVCSRPSLNSLSGAIIDEVGAQDAFVAGMMFALSRRMVPGDPYTPSAMGRDGVDGERDWDIQRGRWRLEECLRFATELAGRKGRRKGWDGLADEMMRAGWFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTZ9</accession>
    <name>A0A401GTZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616611.1">
        <property type="nucleotide sequence ID" value="XM_027760810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTZ9"/>
    <dbReference type="GeneID" id="38782615"/>
    <dbReference type="InParanoid" id="A0A401GTZ9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="285" mass="32348" checksum="5B8C08429CEFDC84" modified="2019-05-08" version="1">MPGNTLRTTETLIERPNGRQPSTVSALQAAIALSKTEFQELTQATRTVVQRRLDIAHRFSEQDPKSIDRVQREILRVCPFIKRYRDYWPVKSYIAIYLSGCMCDPKVNARRKAEILRLAGGSQIEPSESKHSRLSRNEMPQVPSTPCRPRRQFIGQMPRGRRFPSGSPMSNSRSLAITDNARTRTDERATSDFQVRMDELMHIDDVTRPIWDFLQSLAIPAPHLFTILLADGITSIRILRATSKMSACRGWVESLVTTGRATMLEAESLWDGLTELAKVQIPARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU59</accession>
    <name>A0A401GU59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0704510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616177.1">
        <property type="nucleotide sequence ID" value="XM_027760376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU59"/>
    <dbReference type="GeneID" id="38782181"/>
    <dbReference type="InParanoid" id="A0A401GU59"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37504" checksum="D018D3131911A043" modified="2019-05-08" version="1">MKREYEPVEWPTESSLSDAPYPGVGAARPADSQPIKLKFTLKRIFDDSDAHIWGPVVGWGSVFLAGNLCSRFLGIRRCNMGRFRRRLAGACTALGVATFWDRGYYHHARQYQENSDLSTIFHVTWLTFYLASLDPNGRKALLSAASAPLVPSLFARIQGPYFPPDATFAERTRQQLSWLIYQLWLSRRAKAAARFWFQRYLEDANLSPHDIETIITMVAQALDGPEWRLGNALSLCMTLCCSAARALARKHMPVTIWLNCLLAASLGSLAITEGLWPYHYITYPLSIHDKAKAAAALRKYYPEAFERLTAELDEFSGDILGSEPSYVQDGAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU82</accession>
    <name>A0A401GU82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0803000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616691.1">
        <property type="nucleotide sequence ID" value="XM_027760890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU82"/>
    <dbReference type="FunCoup" id="A0A401GU82">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GU82"/>
    <dbReference type="GeneID" id="38782695"/>
    <dbReference type="InParanoid" id="A0A401GU82"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="594" mass="62223" checksum="28D00712C658CC7E" modified="2019-05-08" version="1">MHSLSHSSSSVLRRAAIKAAKPALARGAHKDIKFSNEGRASILTGVDTLANAVSVTLGPKGRNVIIEQAFGGPKITKDGVTVAKSIVLKDKFENLGARLVQDVAQKTNEIAGDGTTTATVLARAIYAEGVKNVAAGCNPMDLRRGSQAAVDRVVEFLAAHTKTITTSAEIAQVATISANGDTHVGNLIAQAMEKVGKEGVITVKEGRTIEDEIEITEGMRFDRGFISPYFITDVKSQRVEFEKPLVLLCEKKISALQDIIPTLEAAAQARRPLLIVAEDIDGEALAACVVNKLRGQLQVCAVKAPGFGDNRKSILGDLAILTGGTVFTDDLDIKLDRMTPDMLGSTGSVTITKEDTILLNGEGSKDSIQARCEQIRSLINDRTTSDFDRTKLQERLAKLSGGVAVIKVGGSSEVEVSEKKDRYDDALNATRAAVEEGILPGGGVALLKASLSLATSSPGSSNPLPTADLKAVPTANFDQDLGVSIIRRALTTPARTILSNAGEEASVIVGTLIANYGSPDKFGWGYDASKGEYVDMIKAGIVDPLKVVRTALVDAAGVASLLTTSEACVVEVEEPKPAAPGMGGMGGMGGMGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU96</accession>
    <name>A0A401GU96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0803190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616710.1">
        <property type="nucleotide sequence ID" value="XM_027760909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU96"/>
    <dbReference type="FunCoup" id="A0A401GU96">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GU96"/>
    <dbReference type="GeneID" id="38782714"/>
    <dbReference type="InParanoid" id="A0A401GU96"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="12378" checksum="5C1B714889CD6202" modified="2019-05-08" version="1">MITWYYIITARPRGAERILIMNEYLQQLLDGKIDFEGQKLVEQIVKITLISSTIFSFLLGFALQSLQVTFGIFALSVIVLCLVVLPHWPVYNRHPVQWLPVKDKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUB7</accession>
    <name>A0A401GUB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0803020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616693.1">
        <property type="nucleotide sequence ID" value="XM_027760892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUB7"/>
    <dbReference type="GeneID" id="38782697"/>
    <dbReference type="InParanoid" id="A0A401GUB7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="8099" checksum="3F1286340098B5B6" modified="2019-05-08" version="1">MIFAKALAEKAVILAKKHLLPVSQHILSSSRPSSTGTGVRITYFGRRLDVDVRGRSPAHMVSTCTRPFLPVRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUT8</accession>
    <name>A0A401GUT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Docosahexaenoic acid omega-hydroxylase CYP4F3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0804770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616866.1">
        <property type="nucleotide sequence ID" value="XM_027761065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUT8"/>
    <dbReference type="STRING" id="139825.A0A401GUT8"/>
    <dbReference type="GeneID" id="38782870"/>
    <dbReference type="InParanoid" id="A0A401GUT8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE85953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="558" mass="61763" checksum="B127B62D3D9D5DCA" modified="2019-05-08" version="1">MDRMLTSTSAALPITPASILQGVLICGIIWALWHSPVRRLFVKSPLDNIPGPASKSFWTGNLSNFVARDGWDLHADISRNYGSVVNMKGWLGQPALYISDPKALHSIIVRDQYIYEETPTFLNLNYLLFGLTLGATLGDAHRNQRKMLNPAFSAGHMRDLLPMFYEVTARLRTAIASRVTSGSQELDMLGWMGRTALELIGQGGFGYSFDPLVDDASDEFGEALKSAFSLAYSMGLLRYLLPLLTKLGPPGFRRRLVDFVPNRRLQRLKITVDLIHRRSTEIFNEKKAALLKGDEAVSQRLGKGKDIISILMTANMEAKSDENQLPEEELIAHISGLTAAAVDTTSNTLAHILQLLAQHPDAQAKLREEIVQARGEDEFSYDQLMQLPYLDAVCRETLRAYPPVTIVDRQTRKDIVLPLSEPIRGIDGETMSDILVPNGTHVFIGVEGCNLSKTLWGKDALEWKPERWLLPLSSTVSDAHIPGVYSNLLSFLGGGRACIGFKFSELEMKVVLSVLLPTFTFELTDKPIVWNVSGIGFPTVGNVSTKAELPLKVGLFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV73</accession>
    <name>A0A401GV73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable mitochondrial phosphate carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0900020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617038.1">
        <property type="nucleotide sequence ID" value="XM_027761237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV73"/>
    <dbReference type="FunCoup" id="A0A401GV73">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GV73"/>
    <dbReference type="GeneID" id="38783042"/>
    <dbReference type="InParanoid" id="A0A401GV73"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000138">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="314" mass="33694" checksum="59B3387F57A5480A" modified="2019-05-08" version="1">MAHLAPTGKWDARLLGPVPHDTSYYAKCMLGGILACGITHAGITPLDVTKCNMQVSPGKYKGLVSGVKTIIAEEGSQGLWKGVGPTFIGYSLQGMFKYGLYEVFKDAYMNLAGEEASAKYKGAIWLAGSASAEFFADIALCPLEMTKVKIQTSPAGTFPVPMVAAMREMSRLKADTRYPFGSIVPLWSRQIPYTMAKFFFFEYIVGLFYTHVFTAPKDTYGKPTQLGVTFASGYLAGIVCAVVSHPADSLVSQMGKPANKGKGLGQIASEVGIVSLATKGLGTRVLMIGTLTGFQWWIYDTFKSSMGMGTTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVN8</accession>
    <name>A0A401GVN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0901700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617204.1">
        <property type="nucleotide sequence ID" value="XM_027761403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVN8"/>
    <dbReference type="STRING" id="139825.A0A401GVN8"/>
    <dbReference type="GeneID" id="38783208"/>
    <dbReference type="InParanoid" id="A0A401GVN8"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="26"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="393" mass="42929" checksum="EB3A9977276AF21E" modified="2019-05-08" version="1">MGSVVSFLHKKRDAAVMSKTIEEKKNVVIVGGGHAGSLLARSLSRTLDSSKYRVILINERPYAIHFLAAARMTVTDEGHIEDGALIPYDKLFINGNGTLKVDKVTAIEETEPGQGGVVVLQSGERISYAALALASGSSWSGPLDFPTTDSEIREHIKEWRLKYGNAKHIVLIGGGAVGIETAGELRDTFADKKITIIQSDKMLLNATYPAKYRKDLEKRVRARKINLVLGEYLDSMPELDTIGITTRSGTTIPDADLVVPTFGPRLNVAYIKTLGSDVLNERSQVKVKPTFETVAHPGVFALGDITDWKEQKQALKGPAHVAVVAPNITSFLAGEPQKKIYKGTPEAIVVPIGKGHGSSYFPYFWGLMFGDYFTSWLKGGDLFIKKTRAERGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVQ5</accession>
    <name>A0A401GVQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0901380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617172.1">
        <property type="nucleotide sequence ID" value="XM_027761371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVQ5"/>
    <dbReference type="STRING" id="139825.A0A401GVQ5"/>
    <dbReference type="GeneID" id="38783176"/>
    <dbReference type="InParanoid" id="A0A401GVQ5"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1082" mass="118120" checksum="C0EC6EA60EDD1DF8" modified="2019-05-08" version="1">MVAAPLPVVSSHDASDEEEECPVCLEPLSFSFRLPGEKPHIVPECGHALHEACFIAVYGPTPSTSKAGNVIRKSNLGVCGVCRRPMKVGDGDGGKSNKLAALTGMGDPNGPSLYPGRETPSSLRSFNTNARNTVTVTKPYDPNEDDPVEHAPKSPNPHDYSPYIVAPSIQVRSEFSTITRTAEQSQPLTCIVVVELPGKRSSTHVPGAVMPAHDSYSSSSPTPYPVDSRSQSVRSSPRPQYAIPPHDPPAPPASQVHTHRVSPVSSQEPLLASLQEREEPQEEESSPFTAITEDLRARIIDWKGHPLEGLGSLQMYDLLSVRRDALVREFFVYLFREAIICVVEEKKRTLGRLLSSASGAAAAFSDGTGMGSAGPSVSKGVLRLKGRIYIRHIKQVTDTSVQGELSLTIDMEDERLDSFILIFKDRSSLETWKAHIQSLVAVYQQQAAAAQQPSLHAPQPVYERAPDLEEFGGSQKAMRMLSGSTTGTTASTMDSLLNGSSRSTISSQTSYGSAAGSRGLHQKLSTLEEDDELTRYNSPTPLVAPHLSSGPSNSLSPLPHPPLDLILVISIPSPHATPSTAALKVRVIRASLDFILASLAPKDRLSLVTFEVGIGGKVRKTPFLCPGKLPSRQRLKKFVDEIGRRDDGTPFEDEFLVRSAQEDKTDVVTAVNHGLDVVLQRKSRNPVTGMVLVSDAADTTRRAQMDLVLARTEAANVPIHSFGYGRSHDPASLWLMSNHTSGTYTFVKDWYDLRDCLAGCIGGMMSIGLLHMKMHMKIVDGQRFRIRKISGGPMAILSSDGRDVDVELGELRYGERKEMLIELELDNSDVAVTPTAQSGPHHMPRALSATDQFNQRMGLDALSIGDSPDLADGMMDRMIDEVPVFEVDGSFFDPAAAKHVSRLAHPVLLTVTLLPMPHPGSRPRTPAPNGSNPVIVRRRMELLASDMITRALVLVSRKNIPQAQKLLSETRRILHTVLQNITQSLPPPNPQGGAPRNRKEILTLSAVRAIQAVMQDMQILSEALDESVDVFAHDQRNFGAQQAMILRDQKSWSGRSAIERLFWTIDNSIELVARSTDWVARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVR2</accession>
    <name>A0A401GVR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine-protein kinase ksp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0901480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617182.1">
        <property type="nucleotide sequence ID" value="XM_027761381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVR2"/>
    <dbReference type="GeneID" id="38783186"/>
    <dbReference type="InParanoid" id="A0A401GVR2"/>
    <dbReference type="OrthoDB" id="2985259at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="408" mass="46586" checksum="73679941F39783E9" modified="2019-05-08" version="1">MLSVAREREVILRHSVSIFLVMTIQIMPSAMIGTICASIMVAIYYVYWWYHERKKLYELRCIRQKLPSDLDTWRVPGRTRDDEERIWETLDPVFRDRGLTLWPNSFGCTLKTPGTAYPTSSGFAYVTPNRSILKGIGSVYHLMCFDYTNPLTRMARTPDGHDVAVRVIVIKNEGHEHLKILRKIATTPRSLLSTNHTLPMIAEFGYEDIIFGIFPRVGSSMKEAFGYWAKNSIGDVMDMLLQALEALAFIHDMNIAHRDAFHDNFLVQWQPESMHSMTIPTSRPRVYLIDFEVAVEYPEECPLAERLTTGYPLGGSFLEPAMYSRPLAPEMTTNKPYCPFKLDVWQLGYSFTSVEFKTTITDIDTILHDMVHAQPTARKSAGETLAILKNVIHNIPPTSLLICPSIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWB9</accession>
    <name>A0A401GWB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0903900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617424.1">
        <property type="nucleotide sequence ID" value="XM_027761623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWB9"/>
    <dbReference type="FunCoup" id="A0A401GWB9">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWB9"/>
    <dbReference type="GeneID" id="38783428"/>
    <dbReference type="InParanoid" id="A0A401GWB9"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="634"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="338"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="622"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE86511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="795" mass="86803" checksum="31CACAC16B0C7923" modified="2019-05-08" version="1">MDAPDPRTRHKVALDPPAVLAKSTVLRQVLLSDVFLVLALQAGKAYLLSPNVGVFWVLVRVLACGGVGSLVWLLASGQLRKKRTVEWLVVAASSLLLFLRQAGLFIALFRLPSTRVIIITHYSALWFKSVLSPTSLLQTSAVLSALLISFLSDAGFSHQNFREMLPAYGALAMEAFSSSVFEHTQGVLLPTLNQPMINMLSVIGAFGFSLPMYMLRHVLTDALPTPSVSMKALSLIVFLAFVVLYQAPKASRAISNPSAPPQYFLLSSASTVIASVVLGMLLLGQYPSVTDCVVAALLIYGTYPKISESASGSPYAATSRTIRAYLKSILSNPESRKIFYFLMLNMCYMLVQMLYGVWTNSLGLISDAIHMAFDCMAIAVGLIASVMARWPPNERFTYGYGRIETLSGFANGIFLILISFFIVFEAIQRLLDPPEMNTSQLLLVSSLGLAVNLFGMFAMGGHHHGGHSHSHGHDHSHGVSSSSSPLSHHAHHESHSHSHKHNEADPRIASHSDEDLHSHSREAIHVHSHSPPLTHTHAHARTHSHLHDHIPIISLDEGAEESIDRLAPPRTKVPLHVHVGLDSHLTDNSPLTPNYKFGHDEHFDTHHASAPNLHDHSHVHEGASEGHSHNMRGVFLHVMADTLGSVGVILSTLLIQFYGWTGFDPIASLFIAVLIAASVIPLVIDTGKVLALDIAEREPVIQQTLSELPSIDGLASYSTPRFWPKDASSVIGSIHIQLSPFPSSYDPSGPSSTRRTTFASVERVVGRVDKLLRSRIAGLEELTIQVEEPILSHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWE5</accession>
    <name>A0A401GWE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0904200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617454.1">
        <property type="nucleotide sequence ID" value="XM_027761653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWE5"/>
    <dbReference type="GeneID" id="38783458"/>
    <dbReference type="InParanoid" id="A0A401GWE5"/>
    <dbReference type="OrthoDB" id="2678679at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1142" mass="124189" checksum="EC29A6F1DEA6281A" modified="2019-05-08" version="1">MDTANSASTDRVNPFCDKPIPEYALQWDSAVCRPATLPAAYDEDISPEHIFYIPSGKEDHSQSVPETTRRGYVVAERCESCKKLRKRCTRARPSCKRCETSGKLCKFSVSPSILPGPSVLRPRKEKQNGSSSSYLPLQEDARSTTTRPDQTVDGASSSNPPAPGLRLSRPRKCKQPRSAPENISSDAVVPESSSDEVQDGAAKPKKRRKHDNIRTFEVPSGSNANRSTAIKRGPKPKNITGTKDKAKPQSITGRRGGLQTSRTMHKPKTTENVPYQPTWHVVPPPNQPTLGGSAAASLGSASTLPRIWANSKEELCEVIPELARSMNGVVWQYTETPTLFLEGQAWPNDLWDGKSVIELSLVRTFSSPVPPGTAADISPPFPLPGRDHSLPTLISPDLPVLPGASAISAPVFSTGAFGTVPHPSYLHPSLRESASDSSMSLPVLTMDGLYTLSASPSPPPEYMPLLPEQRSTDVPWRNGPATFHSISANVVPGPSSGLLVQQDPCQYRDYLIYGGVALESVPPLLPAAVHGSTKFHEGMVGRGVHLGVFASTSADYGDWGKVADMQSISPVADACQFGAVQTEESSTMSAVPIPGSSRGSALQGYYDSSYSYYLPQILQHTQELQRLIATGSAADGALMRSIPGPHVHSQIPETFTHSSTFHGAGPTEIYPPPKLHSSPMDEALNGNPPPEIKALLDCYTKRIPVSIIATRNSSLVRLGLPEEYGCVFLGLFKITEVEIFDRDVNSLQPVQDTRHARHWRFRFVWTPGGDSLDPSVGPLPRWWVPAPTGEGDGEEDQDIDMLMQPYNLLPLELMASSTFSQEDFENGTSELTTSHGWHCGECGMLNVQRNLRHQKCGHCRRGNFMPPVDVGCLRNPYTTAPQILPWDRPSDGVSSFTVKRPDSMRVFRYKLGDSQIATHLFTGNLEKHQDQPTRLFREFQMKIEMPMRGLKAGLGAGPYYTYFVGKEGGVPAVPWADVPECVSAAKELMLHLGRTDGGESSLKIDQLIVLAWTSTGSRKGIFPAKKSCITLLCLGADIELSISVRSEVSPTRMKGGAQAANRAATSSTSSPAASLVLSRRTAKKRKYPSSVQRKTSSAPSKNTWKEALLVTLVHGDILVLTGDDFQYSMKRAGMNIVLIGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWE8</accession>
    <name>A0A401GWE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Linoleate 10R-lipoxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0904260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617460.1">
        <property type="nucleotide sequence ID" value="XM_027761659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWE8"/>
    <dbReference type="STRING" id="139825.A0A401GWE8"/>
    <dbReference type="GeneID" id="38783464"/>
    <dbReference type="InParanoid" id="A0A401GWE8"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1057" mass="117795" checksum="D0D5C6D4993DD38C" modified="2019-05-08" version="1">MSSTVGKTPSRFSTLVENGEQETTARANKIIQEFREQLKRGESFTGDISALRSVIDALKHPNGIDDRKMLLEHVLVFLSEHPSSNLGKQLANDTVELLYADLPHPPETLIGNQYAWRSADGSNNNINIPDLGKGGTPYARSVQQSHPLPRNEMPDAGLVFDTLLKREKFVKHPAGLSSLMFSFAALVIHTVFRTSHKDVNINETSSYVDLAPLYGNDQNNQDKIRVRDGRGLLHPDTFAEDRLLLLPPAVCVLLVLFNRNHNYIAKMLLEINERGTWADPNSIPDDPQRSAKILAQEEEIFQIARLINCAWFASVVFSDYLSAILGLVRRGSSWSLNPFGEIRDLDHTLFERGRGNVCSVEFNCLYRWHATTSVQDEKWTEDLFKQLFPDKTWDQITIQAFVEKAKELHDVELDVSNWTFDALKRQDDGTFKDSELAGILQAATDHPASAFKARGTPAVMRLHEIMGIESNRRWGVCSLNDFRQFLGLKTYSSFLEWNPDPEIATAAEKLYGTIDRLELYPGLQAEAAKPVIDGAGLCPGYTISRAILSDAIALTRGDRFYTADYTPFNMTCWGFADCQRQPDAPGYGSTLGRLFLRTLPGQYTDNSTYTWFPLMTPEAMQPILTKLHDIQNYDLTKPNSVDPVRIVSNYSDVAQVLSSEQFSPRYSNRAARVIHGHGFFIASDSPARAGREQRAFIGALTDARGSVDKIASFFYQTTRDLMLRESYTAVGSRTKNVDIVRDVLKHVPVRWAADLAGIQLKKKPHSLGHYTPQEMFDMLSDIYSYLFLDVEAAKALKLAEKVKTHIEKLRHDLMCTFGGASRLSIAGLLETISHMFFQPAKSDRDDLLDRLHALGYPPETICNTFLAVLVGATVEMSQAMVNVVNFYLDPSKPGDVSTLASKVKLDGNDEALLQGLVNEALRLDPPSRGAYREAAKTSVVGGKPVQLGECVFVDIADASLDATVFPDPNAVNPTRTPQKRYLVGDGSARCLGADLSNKMIGAVLRAVFSFPNVRRAPGQSGVLKRFKEDSTKTSCYSYLSSTQELTPWATSMVIQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWI9</accession>
    <name>A0A401GWI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0904600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617494.1">
        <property type="nucleotide sequence ID" value="XM_027761693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWI9"/>
    <dbReference type="FunCoup" id="A0A401GWI9">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWI9"/>
    <dbReference type="GeneID" id="38783498"/>
    <dbReference type="InParanoid" id="A0A401GWI9"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="58"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="223"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="362" mass="39076" checksum="EF302F9C59616544" modified="2019-05-08" version="1">MGYAQKRLASTAAKLASVSTAHLKAFPPSEAVVSGSSKLHFFDTQAWATLQPAPPTALTAFAHRIGLGKVLTSTDTIQQACTHSSFVPLFKRHHPKDPLPATNANLETLGNSLLGLFATEYVNASYPHLPTRVLKAAVSAYVGPTTCAGIAKEMGATPLLRWHRTSNTPLRPGVLHPDALSSIPRALTALVYQNRSLLSARKFAHKFFLSREVDLRSMIKFRDPKQALLETVAKFGRERPVSRLLKETGRFSKSPVFVVGIYSGAGKLGEGFGSSLKMAEFRAAEDSLLRLYLTRQPPHLVQLPTSTFPEGTGSVLEVQGPESAYVPGAMGDSEVLYGSSGRSGLRAPGRRAQGDEEDLEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWJ0</accession>
    <name>A0A401GWJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0904180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617452.1">
        <property type="nucleotide sequence ID" value="XM_027761651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWJ0"/>
    <dbReference type="STRING" id="139825.A0A401GWJ0"/>
    <dbReference type="GeneID" id="38783456"/>
    <dbReference type="InParanoid" id="A0A401GWJ0"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="333" mass="37332" checksum="FD5B2F1DAB6F2D68" modified="2019-05-08" version="1">MSASDDGEYTERSTTRRRKRRRTTNPRGRSYVESPEPSFSSLLAPVLDVLAERYGTAEGRERYDNGFEQFMDDLLPELTQAEAALLDRLKEVDESGQLVRPLTRSQASELLQKLTSTSSADNQLSALSALVSRKLKLQSGDLRRRLLDVSSSRTHSGPTSPLAARTSSSANPQVIDALYSIQTTPYERSFLSRVQGFQPKRTHGVIAVDWETRSPWMELMSDVRQHFALAHPEREQLVETIAPIEYVTLQASHIDQVHDLLGRVFWAGIDVSDSLQYTPEKCTIVATYKQLVVGAAFLSSPQETYITYLAVRAGWENSQIATYVVPCVVYSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWN4</accession>
    <name>A0A401GWN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0905170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617551.1">
        <property type="nucleotide sequence ID" value="XM_027761750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWN4"/>
    <dbReference type="STRING" id="139825.A0A401GWN4"/>
    <dbReference type="GeneID" id="38783555"/>
    <dbReference type="InParanoid" id="A0A401GWN4"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF3">
        <property type="entry name" value="F-BOX PROTEIN POF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="132"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="618" mass="67971" checksum="8F5538011CD715ED" modified="2019-05-08" version="1">MPVTDLPVELFLDNILPLLALSDLFRLSCTSRLFYLLASDETLWHRKLQDDFNFTGSETARNTGWKFLYKRLANPKVYVWGEKSHGRLGMIKFPQTHVLEGVPYPVHLKIPGARIISLVAGGMSFHALDSRGNIYVWGTLDGTNFALRSEGYSSPGKRAEQPMRLQLPVPFRNISCGRLHCTAIDASSQVWIFTSWGRPFRIASPLLDKSSPETTPLQIESGWSFSSVLTQSGDVLVYWPFDGRTQQVIATTNEELDQSPSPATRARVSATEPDVIPCHWWVMQDVEPTRLPAIPTGSLPQLLGTGLSQDLLGKETKLIKIAALDNTVIGLTNKGHVLKYSMLHGEDSPQHDAWEYLPHFCELGKIRAHPVFSPREPKDAQSRLEPLEIMLITHISAQFQTFVAYSTGSQSVVLLGKINDAPTPHAATPFIPTILPALQYRSVISVVLGDYHYGALTSTGKLLTWGAFSKGALGLGDPTKIEPGQPGGFENEQRLRAALNSQWAHTPPIVQVPTEVRFDYGERAREKYCFAAAASGWHMGALVIDLEPEDESQDDSDAETSTQRMPGAFPQEEPGPNDHHGPGEFPVLPVRGAGFGGIRIGFAGRGMHRGNRPGFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXD8</accession>
    <name>A0A401GXD8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1000940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617765.1">
        <property type="nucleotide sequence ID" value="XM_027761964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXD8"/>
    <dbReference type="STRING" id="139825.A0A401GXD8"/>
    <dbReference type="GeneID" id="38783769"/>
    <dbReference type="InParanoid" id="A0A401GXD8"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="3">
        <location>
            <begin position="179"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ubinuclein middle" evidence="4">
        <location>
            <begin position="345"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="67453" checksum="6F5F9F3CA23D915D" modified="2019-05-08" version="1">MSADVEMLPPRQNSEAAASSSRDSPPHQSLSPIDPDNDASRLARLTIGSEPSGEPSNGLITTDDVDGAPKSTKSKPLSTATAPAAGKSALGAAGAKPKSSKSNLARSPSPSPPPPARPPLQTIRLDIKLGGPDDYEVDISSLSKTTGQRPPTPVPAPKRDISDDSHSEGDDEGDGKNDKKKRKKKNLGQEYYDTNDPFIDDSELAQDERTYFAQTKQKGFYVSSGQVALVNKTPKKPKSKKPNIMAPSASVSAALSSASLPPSLVGPLAGPSTLRPPSPSAKKAKKEDGTRDSPIALYSDAEDEHHTQGLKRKSSASETILTSLSGADHAEGGSKKKRKTVEIQPFHPELEKALDQLREAIAKETWEVKGKFPPSLKPLLAQVALQAIILGEYDDNFFNLMPRLFPYNKFTMTKLIKRTVWREHTNLLIERQNVLLQELKALADEGFPKAKEEYDRSVLSWEKRQERAKAEAEAGGHSVEGTPAASDSQPTPKIPGSALAQRPSVEDADHENGEHEEHAGTGKGKDREPHPPAKRYRLTDTMKALIWQLVCLSNECCRIENEKNNLEGNNQVVSDQGVRKTLYQKIVAAFPEGWLSSGQISRDVSVMKKKYEKEVLENEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY92</accession>
    <name>A0A401GY92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1004200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618086.1">
        <property type="nucleotide sequence ID" value="XM_027762285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY92"/>
    <dbReference type="GeneID" id="38784090"/>
    <dbReference type="InParanoid" id="A0A401GY92"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="114"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="209" mass="23662" checksum="C5A98825C929EF5F" modified="2019-05-08" version="1">MARGTFKQKRGGGRNFSKHLELDENGTAVSTDKWAPRGRRNQENDSDDDDDEEEDEEEEDESDESDDGKAAGSTAQPELSRAERRELKKKKAQAKQQTSDEDEDAEDQDPLFVNPNIAAGKKMNIADLGAPREPTRREREEKEKKEAKERYWKLHEQGKTEQAKSDLARLAKIRAERQAAQAKRKAEAEAKSAEVEAKKKEAVARGKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYG9</accession>
    <name>A0A401GYG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1001680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617837.1">
        <property type="nucleotide sequence ID" value="XM_027762036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYG9"/>
    <dbReference type="GeneID" id="38783841"/>
    <dbReference type="InParanoid" id="A0A401GYG9"/>
    <dbReference type="OrthoDB" id="3198959at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="125" mass="13887" checksum="6D33F413D39B770C" modified="2019-05-08" version="1">MAPTLGEPRESPKPQPLGNFPLIFLFTTCTCCVLFLLWRRASSLRTVVAHRLNTWSRREGNIRLSIDDGPSSREFLDDDYDEDRESLNDDEPLAYTAERLEMGHGTSGGVSAAADDVPPPLPPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYL7</accession>
    <name>A0A401GYL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1005020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618168.1">
        <property type="nucleotide sequence ID" value="XM_027762367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYL7"/>
    <dbReference type="GeneID" id="38784172"/>
    <dbReference type="InParanoid" id="A0A401GYL7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="471" mass="49128" checksum="DC855423B9EC90A3" modified="2019-05-08" version="1">MFSTPYSHAASMHGMWPLADSHPTVDNSNNVASDLFGTIGYAAEPFNLPLGGTEWDIGPWWHSQSHNKSEATLSDESLELLLGPEPEKVPDFVPFPDFAPAFDFDPAEFVAAASPPLISSPLMFFSAPEPAPHPVHNAPTPPAHPLLPMATVVSGSVPSTVPSLPLPAAPAPVSPITSTPSSAPTTGKRTKRALSDSDSAESSQTAARPAKKARKSKAVVEATDVAATDNNYASPTVSTLLHIMQGFATKHWSTPREVIDLTTDEDHPTILKETTRELGEFTKRVLAESVPKGARGGRMCGPAKFAVAPTPSPVLESRAVSSVTAATGCKSRATATDSSDGRQDAVPAAKRKTRAPRKKRNAGVASKGKAVEGKDGSPHATKGTATTSSSNVRAKGKRPVRNVGPPTIPPPVIAMPVDFIHRPRSSTSASSAAGSTGSSNGSTASAPVKSTLAIPMPVVASKVMFDIFSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYT0</accession>
    <name>A0A401GYT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Killer toxin Kp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1005600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618225.1">
        <property type="nucleotide sequence ID" value="XM_027762424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYT0"/>
    <dbReference type="GeneID" id="38784229"/>
    <dbReference type="InParanoid" id="A0A401GYT0"/>
    <dbReference type="OrthoDB" id="2927810at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019062403" description="Killer toxin Kp4 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18730" checksum="1E90A1AD5349865D" modified="2019-05-08" version="1">MQFSWTYLLRLVSASLLMGRTVAAPTAEPELSRAIDARHGDEYLWYIDDAESRHLSDLLGTDFGRLRIKGVLLSKPKMQCENCGKHTGLDDIVHNALQDGVHSKEFMIKVLEDRTSHPSSGHVIRCSGAGCGRAYDEPPPRWTRDWIRGEDTGGQEVHSEGADEEPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYY3</accession>
    <name>A0A401GYY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618290.1">
        <property type="nucleotide sequence ID" value="XM_027762489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYY3"/>
    <dbReference type="GeneID" id="38784294"/>
    <dbReference type="InParanoid" id="A0A401GYY3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="487" mass="53924" checksum="4AB463CFB2679E2B" modified="2019-05-08" version="1">MSQPTLPMETDDDEATTSRPATQQQGRPRSTSPQLQFRTAVMPQALQQPPLPPIAIRSMAAPAIATTSTTTAPTGAGNTAVMEWWVSFGTHQFTLYHTEACAVCYSYLQHIAMARNTAPCQEAHTDALNAEQHLFWEHFQTYTASEGGGRDDVPMQQRNMELQAQLGVAETEATTQRRQVDDLLRKHERLLRLIASSSRPRLPLDYRGQPSGAPRRQPSPLEYLPPLREQRYSPPSTNSSSRRYSPPSNASGSRRRSSVRYSTGGAQRYVPYAAASRPSSATHHTPGMPPPPRHMPPGPPPRSGAPGPLTGPTSGLPAGYVLRPPVGPAPAPVKSRVQRAYEHIDNDESESEPSTDSDNEPNDVEVQRLNKQRQRNHGPMNLPRQGASRSDGKGKTVPRPSDTDNDVSPAPHNWLDSFPLLVNTQPWKATKWYNFVPRYVRDLQRIIDVAHSGDDGARTWATDLIRQMQQDGRLTASHGMMNLLMSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZE0</accession>
    <name>A0A401GZE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1101860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618422.1">
        <property type="nucleotide sequence ID" value="XM_027762621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZE0"/>
    <dbReference type="GeneID" id="38784426"/>
    <dbReference type="InParanoid" id="A0A401GZE0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="136" mass="15071" checksum="EA7D1D8F4B4F5066" modified="2019-05-08" version="1">MAAGSARPMAASSRERDRGGLLERAATWGQSSRDQLRGTWILLRAISERACARSAILRCSFSNYKARPGLSPGPFSLSLFPPPQYLPVNSPAIHYRYLIARPAALHPSLYVSLFSQKVLQQLPKSSPARYRFALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZL0</accession>
    <name>A0A401GZL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1102780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618514.1">
        <property type="nucleotide sequence ID" value="XM_027762713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZL0"/>
    <dbReference type="GeneID" id="38784518"/>
    <dbReference type="InParanoid" id="A0A401GZL0"/>
    <dbReference type="OrthoDB" id="2803682at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="149"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="409" mass="46723" checksum="71DFE1F458C41841" modified="2019-05-08" version="1">MDDSAAESEIITVIAQLARPHATEEEGSEGDVRVRELEWEWVRCLKIQKACILEFSPKPYKWIRFITGVILGAEGILCATDNADAIEIDYDRPLIDGNFSLYFHVTPAELSRMFPLDPYIAEPYCATGSTTEACCDGFRDEVEGRDVRCVASDALAVMCDAAHLIGQSKGDICIKVLTNARSRDEDKNDCIDDIDDIRNGLFVVSQLHRALGRRGVAFLLTPNFAMSTNDVDPTLQPDEQRWTIHSFEAVFDPDFRHDRVCNIAIPHGQALRLPVDRTSWPPGILFDAVYAAAVMKYFSHEDFSAYLSQHWQGRFYLNGDMAQIEHERERNNMKKAQQKRERAERREKGDIEGGGKMDVYDMLLLLPQIVRRPPTAEQRERHLAEQRESELAKRKELEHKVTSWLHTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0U9</accession>
    <name>A0A401H0U9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618969.1">
        <property type="nucleotide sequence ID" value="XM_027763168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0U9"/>
    <dbReference type="GeneID" id="38784973"/>
    <dbReference type="InParanoid" id="A0A401H0U9"/>
    <dbReference type="OrthoDB" id="2756970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="444" mass="50492" checksum="DDD6E09C84C1379F" modified="2019-05-08" version="1">MAELHDSQTNILIQDTSFFNKVRVMIRHAWALREEESPLYMLYSHILTAFCETAGDPLDVDRALGCEPQSSFSAPPGTDFDRRIPDFTVMVAFLQDLAVVNRFSPSYRSPVLGFWVEVKPLNCDAIWISDEAQREAQRAVWLHLEQLNLQGLFAFSHFAGDTFYCMLVLGIYFSVFKYSRPAHLPHPTHPRHPSVSHLSHPDSSQGQKRPKRKRSHDVTSHKAQTNAKQAMERKVLSRSIDTPTTLYYCEPIVIEDGKAFNPLFQKALWDIATSRDIDIPFQPSFFTPPPGDYHASEASLEMAYQDFDQFDRDNEQKEQFIRDAIDSDSSTGEDTSGNYYSSARPSDSGATRRTRSQSRDDALSEADLDALDDTDDTNDNTHSNIEDAIPLDFDFNLDRDVNDGGDGNNNNNDDGDDDDDDDEEEGNMWQYPRGRLARGRESRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H180</accession>
    <name>A0A401H180_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1204160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619098.1">
        <property type="nucleotide sequence ID" value="XM_027763297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H180"/>
    <dbReference type="GeneID" id="38785102"/>
    <dbReference type="InParanoid" id="A0A401H180"/>
    <dbReference type="OrthoDB" id="2793904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9449" checksum="8DBF77E1A169031E" modified="2019-05-08" version="1">MVMSYLTISATSVDVERLFSKGRLLLPHICNGLSAQSIRALLCLGEWSRLGFVQVADILAVTLGLEGKGEDDGLFDGWDAIILPELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1S4</accession>
    <name>A0A401H1S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619271.1">
        <property type="nucleotide sequence ID" value="XM_027763470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1S4"/>
    <dbReference type="STRING" id="139825.A0A401H1S4"/>
    <dbReference type="GeneID" id="38785275"/>
    <dbReference type="InParanoid" id="A0A401H1S4"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="942" mass="106360" checksum="7134B0CC12A66579" modified="2019-05-08" version="1">MHVSDEEPDISVGYQEAYAYSDGEDMHDFESDEDEDVDEYEEPPTRSPSPAPSTDSARSYREAGVTTEYHLYIDGKPCDADGKYLPKDAPPAARPTPATDDWTPYQTQVEFELAEFLYTREQMSAGNIDQLLDLWAATLLPHGDEPPFADAKDLYETIHATKHGDVRWQSFNMSYQGELPAGNVPPWMTAEYDVWFRDPHTVAQNMLANPDFDSEMDYGPLREFNDGERQLKNFMGGDWAWKQADIISKDPDTHGAAFVPIVLGSDKTTVSVATGQNEYYPLYMGIGNTHNHVRRAHRNAIVLIGFLAIPKTDRKYADDVKFRKFRRQLFHSSLARILESLKPGMTTPEVTRCADGHFRRVIYGLGPYIADYPEQALLACIVQGWCPKCTAKNTDLDGDGAGRRSSQHTELLVENLELGILWDEYGLVGDIVPFTNDFPRADIHELLSPDLLHQLIKGTFKDHLVDWVEQYLIVTHGKRRAKEILADIDLRIAAVPAFSGLRRFHEGRGFKQWTGDDSKALMKVYLPAISGHVPQDMVRAIRAFLEFCYIARHNVITSQDLENLEDALSRFHQYRTVFEKAGVKVSGFSLPRQHSLRHYKFLIWEFAAPNGLCSSITEAKHIKAVKEPWRRSSRNEALGQMLLTNQALDKLSASRVDFASRGMLDVPALAASYLSLHPIDDAPDDTANEKSANAGEDGIPFPGPTVEGYVTMAVTKQRKHSRNLHYLAVEVNQPDLPTLVRRYLYRQLNPYSALPICDIPLDLCPVFNAKPKVYVHYSAAAVYYAPSDPSGIGGMRQEHIRATPTWRRKHPRFDCIFVKSAPRNDRIIVSAVDPCIARVLLFFSFTYDGKRHQCALVRWFECIGDQADDATGMWMVKPAVTAEGSPSTAVIRLDYILRSAHLIPVFGEGTIPLNLHEHHSLDAFHTFYVNKFADHHAFELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2S5</accession>
    <name>A0A401H2S5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1400980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619606.1">
        <property type="nucleotide sequence ID" value="XM_027763805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2S5"/>
    <dbReference type="STRING" id="139825.A0A401H2S5"/>
    <dbReference type="GeneID" id="38785610"/>
    <dbReference type="InParanoid" id="A0A401H2S5"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="136" mass="14525" checksum="F83C774F4CB0F7A9" modified="2019-05-08" version="1">MPKKGNAAAEKKSADKKAGKGAAKGEEAGEKSKGKGGLKPATAINVRHILCEKHSKATEALQKIQEGQRFDKVAQEYSEDKAKAGGSLGWMARGSMVGLFQDVAFALEPSSVDKPILSPLVKTNFGYHIIMVEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2V8</accession>
    <name>A0A401H2V8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1401340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619642.1">
        <property type="nucleotide sequence ID" value="XM_027763841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2V8"/>
    <dbReference type="STRING" id="139825.A0A401H2V8"/>
    <dbReference type="GeneID" id="38785646"/>
    <dbReference type="InParanoid" id="A0A401H2V8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="472" mass="51680" checksum="A22B0B94E7D104AB" modified="2019-05-08" version="1">MSVTHQDTTSVEEKAAGAFQTATFLVEPLHGERRLVRRLDARIMPIVCLLYLFAYLDRTNLGNARLQGLPGDALNGDPTGVLFEWVNSVFFFSYIIFQIPATITSKLFPPRIWLGCSALGWGLCSTLSACGFNFAGLTVARIGLAFYYTKQEIGMRLAYLFGFGAVAGACGGLIAFGVQNAHTALANWRLLFIIEGLPTIFLGVLCLFLLPDRPEETTFLNERERELAMERVNRGIKADIGRTIKKKHIAAAFLDWKIYAAGVIYFGANCALASISAFLPTIITTFGYSNALAQLLTVPPYAVAAIILCSTSYCSDRLQIRGFSVVAASMLGVLGYVLLLAVPYNDHVRYFATFCITSGTYTIIGVVIAWFTHNLGSETKKATGIPMYIAIGQCGSVLGSHLFPTTDGPRFITGFAVSCALEFVSAVTAIILTMYYRMENKRRDGKFGKPIRDAMVDTSELADMAPDFRYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2V9</accession>
    <name>A0A401H2V9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619613.1">
        <property type="nucleotide sequence ID" value="XM_027763812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2V9"/>
    <dbReference type="GeneID" id="38785617"/>
    <dbReference type="InParanoid" id="A0A401H2V9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="646" mass="72812" checksum="36A426985C39ED20" modified="2019-05-08" version="1">MYDEYQQVRLSPSLNMGLLRNLYSYPLVNGVHALLLDVYQNQHAKDHGLDSAAYLWTKDLADFLPRFNYVRDVTIQNIVWGIVARPTREVFLNHFSMIGRLELTHVDFWNTHQFLRVLDAFPRVQWLCVTDISFQWVNHTQRQVSGTVPRAFHHLHYQGKGLSIFVDWLLGDGRDVFIEELIIRSNYPDLEDLVKLFTRLAPHLASFAFEQFPEQEWNACLDNELLTKDEHLVGPSREGTSSNNSDGVKKRITERQVIYDPEDDYKEDPAEDSGMRLTRLVERLQQNENVKRTTAYTKMEKDIGYEPPEALAQSFRMDALENIVAQLHWGDITLLTIDIMGQLVSSRTRLFNLELTFEDLDDLMSLPQELDPVLDDITLQASHNSDFTVVFRSSIQVNDAKFLQEMIIANLPRARVNPLLKFVFDIRETAGGRTEAHVLQDVLPRITPFEFHVLSTLDVGGAQLQPSAGPMRLPESHPQPVAGSPQYSSPLAGFGSLVMDASHVVSSTRPPPHAQAGVLYQAAVPQQRHFHPADDHCNIAGSSGVVFSPQLDTYAGVSYPQQAGGSFQHRSSPGDVFGLSFDPPQFSGLSQPHAVAEGMSIQPVARILQCQPQPDYVPSTGEQRERMVDCIVHRSPGRGKGTTREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3G2</accession>
    <name>A0A401H3G2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619881.1">
        <property type="nucleotide sequence ID" value="XM_027764080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3G2"/>
    <dbReference type="GeneID" id="38785885"/>
    <dbReference type="InParanoid" id="A0A401H3G2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="218" mass="21710" checksum="A4F814741961EFE1" modified="2019-05-08" version="1">MWGSGADESEETDDARQSEVVPTHAQADSNTTNASSQPMANPEAVNIAATTTSTRNDEVAHAIDGVMPTTTSSPIASMPSSTSSTTKCTTQARDSGTACKKPRTGQPLRDFINVITAPDGSGIAVQKKPCKTRSDKGVKKGLRKQRALTGENANPSAASGTASPSAASGTASSTAATTSATTTTSATTTTSATTTATASATAIAPTSPATAASVLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3T3</accession>
    <name>A0A401H3T3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Oxidized purine nucleoside triphosphate hydrolase</fullName>
            <ecNumber evidence="13">3.6.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">2-hydroxy-dATP diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">8-oxo-dGTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Methylated purine nucleoside triphosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nucleoside diphosphate-linked moiety X motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SCP_1500910</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71395"/>
            <dbReference type="ChEBI" id="CHEBI:172878"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63212"/>
            <dbReference type="ChEBI" id="CHEBI:77897"/>
            <dbReference type="EC" id="3.6.1.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71361"/>
            <dbReference type="ChEBI" id="CHEBI:172871"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:65397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-methyl-ATP + H2O = N(6)-methyl-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
            <dbReference type="ChEBI" id="CHEBI:172873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N(6)-methyl-dATP + H2O = N(6)-methyl-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169976"/>
            <dbReference type="ChEBI" id="CHEBI:172872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:67605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>O(6)-methyl-dGTP + H2O = O(6)-methyl-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169974"/>
            <dbReference type="ChEBI" id="CHEBI:169975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:67601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.56" evidence="13"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620001.1">
        <property type="nucleotide sequence ID" value="XM_027764200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3T3"/>
    <dbReference type="STRING" id="139825.A0A401H3T3"/>
    <dbReference type="GeneID" id="38786005"/>
    <dbReference type="InParanoid" id="A0A401H3T3"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008828">
        <property type="term" value="F:dATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003563">
        <property type="entry name" value="8ODP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01403">
        <property type="entry name" value="8OXTPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="24">
        <location>
            <begin position="22"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00053094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GBE89088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="198" mass="22088" checksum="A90DBAFD1B3D23CF" modified="2019-05-08" version="1">MSSERLDEVARGGVPDWLPFSKIKLYTNAFVRQDGKLLLGYKKRGFGKDLYNGFGGKVEPGETPAQAALRELEEESGIAAPLEHCGVLFFVLPDLEQAFHIDIFRAEEYSGAITESDEMRPQWFDIEPAYATPNAKPAAADGSPKEHNTGLPPIPYDQMWADDPFWLPLMLAGRHFAGRADFGSDGRLQKWWFGAKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H438</accession>
    <name>A0A401H438_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1501680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620074.1">
        <property type="nucleotide sequence ID" value="XM_027764273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H438"/>
    <dbReference type="GeneID" id="38786078"/>
    <dbReference type="InParanoid" id="A0A401H438"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE89161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="430" mass="46043" checksum="5B99E64AF11B570E" modified="2019-05-08" version="1">MVEDKYIGLALAVSSSLAIGTSFIITKKGLNDAAERSAYATASDDYSYFKSPIWWAGMSTLVLGELANFAAYTFAPPILVTPLGALSVIIGAILASLLLNEELGHLGRVGCALCLLGSLIIVLHAPADKDIQTVDEILHYAIQPGFLLYCFTVLVFTLVMIYAVVPRYGRTNPVVYISICSLVGSVSIMGVKGFGVAVKLTFAGHNQFTHPSTYVFAIVVVTCILVQMNYFNKALDTFSTNVVNPMYYVGFSTATIVASVILFQGLNTEDPANSISLLAGFITTFLGVHLLEISRKPEGLPTANGHSALEGGLMNPRLSISGRASIDGWNGTAGTPVGSGGGFGMDGNARRGSHQRGPSLPLFNTLDDEGPDSVGLSRLPEVDEDDDELDAVDERTHLRSEERRQLQRHGSRSASQSPVQLPSDPRRVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4E5</accession>
    <name>A0A401H4E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620197.1">
        <property type="nucleotide sequence ID" value="XM_027764396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4E5"/>
    <dbReference type="STRING" id="139825.A0A401H4E5"/>
    <dbReference type="GeneID" id="38786201"/>
    <dbReference type="InParanoid" id="A0A401H4E5"/>
    <dbReference type="OrthoDB" id="5354526at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="530" mass="60773" checksum="9CE240845D92E9EF" modified="2019-05-08" version="1">MPSRGVSMMDAPWGPDDVPAEIWMEIFEWLPSSADLYNVLLTCKTFCALTVRALHRDVTWHKPEEFAQDLPAWDTNQGMDAVTHSLKIGFSFVPPALNGWVVHLDGSSTYRWRNDLIGIDTVRLYNTVQYYALHKTSFASQPLYDEMFTRISSFTNLQNLTFYNVIFYNRHFALIHELPGLRTLRLELCVFPNRARSRFFDHSTLPITELTMLNLRRRIAENHGDRSVTVEEDIVHALSLATAQNLRILRIDSTADVFRNVFSGFEQELHDFTIPPHLEQLYVLRKRSLAGEVQPTFPGESTFPDPSLYTFLRRARTITTYSTYHAAAPHLLWAPESLPQLRHYAGPIETLAGITPERPIDALVLLRCGYGVRDGVTALAGVAQVLPDLEMLAVEFRTWDDEILHAVTTLFRKLRRLRIVCDHGGPSETTLVSIGPEFLTRLPHLHTLQMYVMPVQDGGMRPLYPTSMFDPSYTSVEEELQNLVIPWNRWCPSLREVQLLGGYVLRRGFDGGAWQVYKVARMPEWESFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4F0</accession>
    <name>A0A401H4F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620143.1">
        <property type="nucleotide sequence ID" value="XM_027764342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4F0"/>
    <dbReference type="STRING" id="139825.A0A401H4F0"/>
    <dbReference type="GeneID" id="38786147"/>
    <dbReference type="InParanoid" id="A0A401H4F0"/>
    <dbReference type="OrthoDB" id="2743768at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13706" checksum="CDF01E96543146D7" modified="2019-05-08" version="1">MFPSAIDGDLLELVHLSYGLRLVDDAKHLQAGDVFKIETHIVSVINSNAGKTVRVKCFAIRGRKPVIEVVSTFLYHSNYSEYDNTFEFFDTLDYSIELATEADVLQSVFWMAPPSFHVSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4I6</accession>
    <name>A0A401H4I6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620224.1">
        <property type="nucleotide sequence ID" value="XM_027764423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4I6"/>
    <dbReference type="GeneID" id="38786228"/>
    <dbReference type="InParanoid" id="A0A401H4I6"/>
    <dbReference type="OrthoDB" id="2811214at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="114" mass="13144" checksum="99EA4094BD5BD299" modified="2019-05-08" version="1">MQIYGGYRLTEEQVKAWCHSQGTDPQPGTYIVVIMRYLTANHIQIDVLPCDYEGECIHLVVTDKKADYDATPDKYEQLQESDRARAIKQKVLDQGFDSADFVTVPDPYKVWQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H505</accession>
    <name>A0A401H505_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1601870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620438.1">
        <property type="nucleotide sequence ID" value="XM_027764637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H505"/>
    <dbReference type="STRING" id="139825.A0A401H505"/>
    <dbReference type="GeneID" id="38786442"/>
    <dbReference type="InParanoid" id="A0A401H505"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="523" mass="56185" checksum="09962F63FBF6DE41" modified="2019-05-08" version="1">MSVISTAITDLFNIKHPVLLAGMNVAAGPELAAAVTNAGGLGVIGGVGYTPKILRAQIHALKADLQDKNAPFGVDLLIPQVGGSARKTNYDYTKGQLPELIDVIIEEKAALFVCAIGIPPSWAVEKMHKAGIPVMNMVGHPKHVAKALSAGVDLICAQGGEGGGHTGDVPCSILIPACVDACKGHSSPLTGKPVYVIGAGAVFDGRSLAANLMWGAQGVWVGTRFVASVEAGAPKAHKDAIVRSGYDDTARTLIYTGRPLRVVRTPYIDDWNNNRQAEIKELTSKGILPHDEEMRKHPEKSLEARSFLTGAVASMIQDVLPAKEIVESMVNDAAKYMQAGAALVTVRAKLTCVANSIAHSRVCRLFKRAGAFLLREYYHGICHLMEASEVPSKSYRSQIRPLPSSADIIRFSDQVDFHVRQAILAEASACEHQASMNMCPSSMRSRAARITASSTDMARRPRASYNLKCLRHRLAIGCGFVAVCAKVLKDTPTCRRFALEDLRSFADSNAAPVDMATPVWNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H606</accession>
    <name>A0A401H606_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1702030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620790.1">
        <property type="nucleotide sequence ID" value="XM_027764989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H606"/>
    <dbReference type="STRING" id="139825.A0A401H606"/>
    <dbReference type="GeneID" id="38786794"/>
    <dbReference type="InParanoid" id="A0A401H606"/>
    <dbReference type="OrthoDB" id="2799673at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE89877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="295" mass="32712" checksum="AC147D2A7945F2F3" modified="2019-05-08" version="1">MTKWGRYGPAQSEFDYTPATVRESVRRSLAQLNTDYLDVVYLHDVEYVCTPVGPQEAGDHTAALAEVRAAEYGLAWGAEGKVWGEGALKILDALAELRKMQGEGFIRAVGITVTALTRLHPPDAGLFSPVGDFGVLSTSRWTTLSHPAFPNYDTQVGPLRKIPPTRAYTGYIDIEARHLFFYFFESRNDPTNDDVIFWTNGGPGCSSSLGLFMELGQIDFSVVLVVTFMQNFRSGTHGRFIAAFFSGQAALQVYWIRQLFNLNGEGYRRLDVSPPNTSRALNKSMAETNCDEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H628</accession>
    <name>A0A401H628_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ent-kaurene oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1701680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620756.1">
        <property type="nucleotide sequence ID" value="XM_027764955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H628"/>
    <dbReference type="STRING" id="139825.A0A401H628"/>
    <dbReference type="GeneID" id="38786760"/>
    <dbReference type="InParanoid" id="A0A401H628"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="522" mass="58146" checksum="66343F2DEA3F549A" modified="2019-05-08" version="1">MGRSINSSLSTRSTTSSSCSVAMDNTVLLCALIGLISVLYFSHKRSNKALPHIPAVGPSAPVLSYLGAINFFRNAQGVIQEGYNKYKGSVFKIATFEQWVVVVTGPKLIDELRSLPDDQASFGEAVNEMLHSEYTIGRDVSEDAYHIGVVRGQLTRNLSALLPDVIDEVGMAFEEHIPVNDEGWLEVSAFSVMTQIVARASSRIFVGVPKCRDRDFLNLAIDFTTDVIMGEVIIGFFPTVLQPIAGRLFSRLGSSTRRATAHLRPIIDERRKKLAEYGEDWSDKPNDLLMWLMDEARSGGRPDESVIPRVLVVCFAAIHTSSNSFTHALYHLAANPAYVQPLREEIESVSKAHGWDKTSVDKMWLLDSFLKESQRMNGTECTALHRKVLRDVTLSDGTFIPAGTRMVAASMSTHLDEEYYANPNVFDPFRFCKMRAAEGEATKHQYVSTSPEYIPFGHGRHACPGRFFAANELKVTLAYVALNYDVKFEHEGERPKNVWISTTVLPAPNAKVMFRKRQSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6D7</accession>
    <name>A0A401H6D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620918.1">
        <property type="nucleotide sequence ID" value="XM_027765117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6D7"/>
    <dbReference type="GeneID" id="38786922"/>
    <dbReference type="InParanoid" id="A0A401H6D7"/>
    <dbReference type="OrthoDB" id="2756799at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1055" mass="115840" checksum="B68C65A7994E82DB" modified="2019-05-08" version="1">MFCPSTVFHDIANSSDWPPRVQEVVHLLTQPLPDYISTGPWPFVSPLASYLLNELGENSPRQRELQHEGQSVSRVNKVFDLVLSTVAALRELESLEDCGRARPTVPLWSLFFKVIGIACSPECCYMDEVSFILPRLSPRSSQVILDGTATLLISHIVDESQFVHSCSSSDAMDVDASSEPEDDQDGADASSSHNSERTSIDGTHSTAYSEGDYTDDQDSTDETSEQLSGPAIDVPFDAHVLRGSGRRLFAVLPVICVADSDNIGALVTSVAYQRRVWDIDEPVVGFEVSKTGAVARILLGWVGAEADGNYLPAVHIACATTHSHSGMTVGIFNLTDPQSALALAHFVLGLDAHCRRIVSKSKHRPVIDAFHWRSDYLEKREDSCNNGDLGTRIANWASTIDTRSDGGNPEAELDLSMSPASDMSDLSMILESPGKPTQGRGRPTTRSAGSQTGSGSRKSHSRVKEGAVATKGRSRTPATDKASQKQESKAPKSRSDSVAPRSERSSSVLAKKVKTALDGLVTPATWLFERKAFPIALIKLPHDAEDADEINEKIDTYKKIVVEFAWCNVEWSSIDAMPQVDEAVQQVLEHLFQNYSALKEKPVELDEADMRILSNRFSTILYASMGAYTHHAASSGLPVNEAEARHDWDRMLYQFCVPDSEHTVSPYLLLERELIFPRNKAIDFILDDNSPEKQKSLAKQQKNFAESYYVHCLAVQGHSLRYSTAVQVQADAASTQALHFSVQVNSLSENPGEMVDILRKHAASEPLRGICDAIVVSGIKDAFDDKDSPATRKFLNKQALVQHTLTTRSKKDQPEKLASQTSSHPPPTPAVEAHPKASGSKTTSAPKTTSTPKTTSARSRAPSAQSTLRNRVGDPFVNSCSPLVSGSSIKHDNIPRRDPEAITRDQLLLPVLVAEYKRWDEDQAKSLNQGRFYCVASVTFLAALGIEGYPVFALVTNGKVGAVLLSWQSPGMKKKIYIIERNVCTFDLGDPLQAFHFATFLVRLRHQHGQLKELFEKEKEIFRGKVSAEQFEEWMMTAQDVILKAQQAAADAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6F3</accession>
    <name>A0A401H6F3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1800260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620917.1">
        <property type="nucleotide sequence ID" value="XM_027765116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6F3"/>
    <dbReference type="STRING" id="139825.A0A401H6F3"/>
    <dbReference type="GeneID" id="38786921"/>
    <dbReference type="InParanoid" id="A0A401H6F3"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE90004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="72" mass="7937" checksum="7E500BA1C0CD525E" modified="2019-05-08" version="1">MSAPGSSTKQDAHNHSASGDDEYTPRTPRRTPMACQFCRGRKMKCDGRQVCSNCNRRGIACTYAPVESNKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6T4</accession>
    <name>A0A401H6T4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1801170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621006.1">
        <property type="nucleotide sequence ID" value="XM_027765205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6T4"/>
    <dbReference type="GeneID" id="38787010"/>
    <dbReference type="InParanoid" id="A0A401H6T4"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="88" mass="9914" checksum="2AA3CC7D42C43681" modified="2019-05-08" version="1">MTPNDLVTAIPSILEGQTRPSPGDVLILTAVLSFNLDGDCMARWVLGKKRLERMRNERWMMVAYRADMRLPFTHPALASEWKEAAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6Y2</accession>
    <name>A0A401H6Y2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1801650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621054.1">
        <property type="nucleotide sequence ID" value="XM_027765253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6Y2"/>
    <dbReference type="FunCoup" id="A0A401H6Y2">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6Y2"/>
    <dbReference type="GeneID" id="38787058"/>
    <dbReference type="InParanoid" id="A0A401H6Y2"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="168"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE90141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="546" mass="61531" checksum="8AC6926BFB859C17" modified="2019-05-08" version="1">MEGSGCPHISFTLANTAEETAIFRKYKRIISWDSQRRHDAIRPAKRRKTAVPACGTCEAALSRPVVCLNCSYSGCWPKAHAKRHLQETNHKFCVDAKTGSVYCSECNDFVYDSRISHAYFSAAIAAEERNTSFQVDKKSREPFQAWMPNEQETAMLRQTDNLSCQGRRGLLNLGQTCFLNVILQSFVANPLLRNYFLSDKHNQKLCKTKDCTCCEMDKLFTEIFSENTTPYGPTSFLATTWRASSELSGYAQQDAHEFFIAALNQIHATSRGSTIFQCICIIHSTFAGLLQSDVKCERCGNVTTTTDPMLDISLDLKDKDKGSTAVGQQVTLASCLKKFTQPERLGPNEYSCAKCEKASHECSKRLSIRKLPPVLSFQFKRFEHKSGDKTTAHKIEAPVRIPASLNMAPYTSLVMDTKSEEGKGSGMGHSTSFPHIGPEALYEYELFSVVCHEGQIDNGHYTCYARSQDEWYRFDDDKVTHSSLGACLNSQAYMCFYVKRHLDYKPYTTPSYKITREAEAIKEKERELAKEAARVKEFEDALLATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H710</accession>
    <name>A0A401H710_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1900870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621151.1">
        <property type="nucleotide sequence ID" value="XM_027765350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H710"/>
    <dbReference type="STRING" id="139825.A0A401H710"/>
    <dbReference type="GeneID" id="38787155"/>
    <dbReference type="InParanoid" id="A0A401H710"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="155"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE90238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="407" mass="45459" checksum="6F5178701C2350B2" modified="2019-05-08" version="1">MEHTLNDFQKSSANPVTQAVRLMHNHSVPAVNIYGWDTPSLPLPSFSAATFDAFWSRNIPVKITDVDSKFQGVWGPEYFVAQFGDVKVTLQDCEAEIAKTSTVGEFFKTFGNQQVAERATIMKLKDWPPEKHFSTQFPELFKAFMDGVPYPDLARLDGVLNLAAHFPQNGIPPDLGPKMYNAHGSKHDNLHHGSTKLHIDITDAVNVLLWAADTADGELGGALWHIFPAVSAPEIRRFLTQVYDFRGPGDPIHSHSVYFTPEMLNNLEAQCSIKPYVLFQRPGEAVFIPAGSPHQVSNQTDAIKIACDFISIANLAHTQNVVDELREQRLLSGWGDDVLQFYTTLWYAWTSVSALATFPLLAQLRSLVPLRMKLYFPMDVSTHILNNVPMTILDYCTRNNGGRTGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Z9</accession>
    <name>A0A401G4Z9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0100960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608137.1">
        <property type="nucleotide sequence ID" value="XM_027752336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Z9"/>
    <dbReference type="GeneID" id="38774141"/>
    <dbReference type="InParanoid" id="A0A401G4Z9"/>
    <dbReference type="OrthoDB" id="3266475at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019262038" description="Transmembrane protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE77224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36135" checksum="ABDA22FA660283CE" modified="2019-05-08" version="1">MRFRVVLFIAGICPLVSAATLSGNRRRLSVVSAHGERRGLGDIFGGFEPDTPEGDGTSEQVSTNSIATKTDGNPFAMFSPFGTTTDTSTTRKDAASTTSITSSSKSSSTTTPPPSTTAQATYSTPTPTATNAPSTPSSSSSTSTTWKVIGVAVIAVGAVAAILLVTMSFDHWWGFVRDVVCRRRPREGAEEFVPDWEKASWDVRFPADRQRYPSFASLPDALAQRRVMSGAGPAEDSAGIVPEVYAHGASSPLEKMVSPGPFRRVRPDPSPTATSNPFSPHLRSTSCNRSSRHPRPTSGNHASPRPRPPPRTSMDITSPTPTDAPVAPADAYDGIEKNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5V3</accession>
    <name>A0A401G5V3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0104120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608450.1">
        <property type="nucleotide sequence ID" value="XM_027752649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5V3"/>
    <dbReference type="STRING" id="139825.A0A401G5V3"/>
    <dbReference type="GeneID" id="38774454"/>
    <dbReference type="InParanoid" id="A0A401G5V3"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF44">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="628"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="812"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE77537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="880" mass="99368" checksum="13F6923040624345" modified="2019-05-08" version="1">MAYRPQPQHDRYNSPQPGYAYADYPPSTGSVVPDLPPAPQHQQRQYTAPQEVYNHHDHYADYDAQLNWDSKSAKSFQSSYAGSHAHLNPQYEMSQVSLHNLPPIPTMPYQQNYPPMQQGRPGVGWSAAREMLLKQRVVRKVELQQGNLILDMQVPSHIVPKGMDNVEEMTKLRYTAATCDPDDFMRYKYSLRPYLYKRHTELFIVMTMYNEDEVLFVKTMNAVIKNVTHLCGRSRSKTWGVNGWQKVVVCIVSDGRSKVNKRTLQVLSLMGCYQEGIAKDSVGNKDVTAHIFEYTSNVVVSEKGEVSMGACPVQIIFCLKEQNKKKLNSHRWFFNAFGPLIQPNVCVLLDVGTKPTSTSIYELWKCFDKHSNVGGACGEICVDTGRGCSLLLTSPLAASQNFEYKISNILDKPLESVFGYISVLPGAFSAYRYKALLNGPDGRGPLASYFKGEAMHGGSSGAGLFERNMYLAEDRILCFEIVTKKREGWVLKYVKSAKASTDVPTTVPEFISQRRRWLNGSLFASIHATVFFWKIWPSGQNFFRKIILQLEFIYNAVQLLFTWTSLANFYLAFYFLVSSATSSTSNAFNFLSDSAGQDVFQVFLKLYIALIFVVTVCSLGNRPQGSKWIYALCMVLFGLCNVITLWCAGYTVYMAVPHTVAGWKNFPNLVKTNAPFRDIVISLAATYGLYFIGSFMHLEPWHMFTSFLQYMFLLPSYVNILMMYAMCNLHDVTWGTKGDNGSAKDLGAAKKVKGENGKELMEVELPTAREDVDQLWAASRQALSVKALEEKQHRDAATKQADHDRSSRTNVVLAWIGTNMVMILVFTSNLFIHWVDTHFTSEDGAPFNPYLSFLFYCLAGLSAIRFLGSALYLLLRLVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5W3</accession>
    <name>A0A401G5W3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0104340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608469.1">
        <property type="nucleotide sequence ID" value="XM_027752668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5W3"/>
    <dbReference type="FunCoup" id="A0A401G5W3">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5W3"/>
    <dbReference type="GeneID" id="38774473"/>
    <dbReference type="InParanoid" id="A0A401G5W3"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="154"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="572"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="380"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="834"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="783"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="845"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="877" mass="97005" checksum="E22ECE34FF37C13F" modified="2019-05-08" version="1">MSSDTELFLPTTFPYPIRLVALAAHPDDKIHRGARLLSYSFTYTPPGASPELRFGTWDSSMEGTVKRWSFREGDIISARKAKEVAAVYVNEPCKHGVQLGGLCCLCGKDMTDYDYTGFSDASRASIQMTHLANGPTVSLEEAQRIEKETAENLLSTRKLSLIVDLDQTIVHATVDPTVGEWISEGEAWEVRQAEKAQAQRDKGNDSDDTTSDTDDEVNPNWEALKDVKKFRLGPEALGQPPRGANVKGRENTIEQEGCMYYIKPRPGWNEFLQTMATKYEMHVYTMGTRAYAEEVCAAIDPDGKIFGGRLLSRDESGSLTQKSLQRLFPCDQSMVVIIDDRADVWEWSPNLVKVIPYDFFVGIGDINSTFLPKLDSLASAIPSGPPPTPPKEPSIEDATPTQGEEADLSLSISSEEPPPISESVITSAEEPQADETSDFVKNEILERNTMALEAQFEERPLAKKQEALQEEEEKEEAAQSAQSAQIAEPQPADAATSTPPAAPAPHHHHKERKPLLKNDDYELIRVRQLLEKVHEQFYAAYDLRSPVTKTSKRKGAAPPRVPYDVRSIIPVMRADVLRGVHILFSSVIPLDTRPEVTEVWRTAHAFGARCYTELSGRITHVVATKRGTVKVDSARRQGGIKIVWLSWFTDSVALWQRQDETRYLIDPEPPVPARLASPPSDPHQISSDPEPDADDWDEERTTADGERLALDEVDWAEVNDEVDAAMNESDDDDGDGDGDGEQSEKGQSANVSEDEGSWTDESNSLISSAPPSPRISRKRLRSLTPSESGLNGNVNSDALRSRLAKRRKMVADRSGASRLKEEIIVDEIPAEQPPKLAALPVGGNVDDEEDGSDGDAEDDGAMDEDDFLARELEEEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G641</accession>
    <name>A0A401G641_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0105040</name>
        <name evidence="13" type="ORF">SCP_0507440</name>
        <name evidence="14" type="ORF">SCP_0802060</name>
        <name evidence="15" type="ORF">SCP_0900190</name>
    </gene>
    <organism evidence="12 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608537.1">
        <property type="nucleotide sequence ID" value="XM_027752736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G641"/>
    <dbReference type="SMR" id="A0A401G641"/>
    <dbReference type="FunCoup" id="A0A401G641">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G641"/>
    <dbReference type="GeneID" id="38774541"/>
    <dbReference type="InParanoid" id="A0A401G641"/>
    <dbReference type="OrthoDB" id="3345619at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="11">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE83688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE85684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE86142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11366" checksum="AC48D0028C50C948" modified="2019-05-08" version="1">MSGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDSVTYTEHAKRKTVTALDVVYALKRSGRTLYGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G682</accession>
    <name>A0A401G682_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein lsb5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0105500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608582.1">
        <property type="nucleotide sequence ID" value="XM_027752781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G682"/>
    <dbReference type="FunCoup" id="A0A401G682">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G682"/>
    <dbReference type="GeneID" id="38774586"/>
    <dbReference type="InParanoid" id="A0A401G682"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="5">
        <location>
            <begin position="186"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55972" checksum="B01DF4E71C198381" modified="2019-05-08" version="1">MQLAKQAYTAFNREKPHSSITEWIEILTTTEYEDEAYDGIPEVVDSINIQATGPAEASRAIRKKLKHGNAHQQYRALVILRAIVENGGHKFQTSFADSQLTDAIRTIVSDASTDPKVKKKVISVLSSWHSQFKDDPDMQLVAGLARQCRIPDVQREAHRIQAHKQAMETETEERKKREEEKQQKEEEKRKAKEKAKKERERKEEEEKRKKAVRSKVKRKAFDFEQEKPQILIAIANASQASNNLVNAITLVDTAHDSLQRNERVQDCLGKAKLARKQIVRYIQLVENEDVIGTLIESNDRIIAALESYDRLSKPNITETDVKDVQEGLAAAKLNDSELGKLQEKQRAAVQRSLERAGSSAQLYEKDRDTGTAEYVHPDLQDLNFGLLGAEEKNLPPPLQPSAPRSYDDDKWRRGSLSDFSDYQSSDEEAHERNAASGSTSPRGYVDVSDDEDVDVRRDPHKGLLEEDPFADPFVDQDDPGTPELPSVGRREVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G696</accession>
    <name>A0A401G696_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0105550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608587.1">
        <property type="nucleotide sequence ID" value="XM_027752786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G696"/>
    <dbReference type="STRING" id="139825.A0A401G696"/>
    <dbReference type="GeneID" id="38774591"/>
    <dbReference type="InParanoid" id="A0A401G696"/>
    <dbReference type="OrthoDB" id="3071736at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="430" mass="46872" checksum="804AD3F232B5F9F5" modified="2019-05-08" version="1">MNTTLQPHLSSPSKPLTDTKPSTNMGHDPSTIRAFKTHLHRRSSRIERWVEEQHTITSDVEEEELGGVPTVCHPYLAYPHLSVPSLLIQDDKSSTGGDGFLDQPATKMAKRVSDAKSSSFPPGNEPSTPPKGSPARQIPNASRPTSPLRGLQLPFGSRRHLNSVPDVPRVHSPASSALSRQDPSNRHAPGSSISTTYSQPRVFSLDTPPRQQPPWKMKRRAVMGHFASPSDTERASDAYPPRPSTSSSVTQSSTTTQTRTSLDTPTTPRKWDLGSVRGHPPSVFLNSASSLWSLPVDATHLNDPPDSTKVLAQDKDKHSTVRIPLSLKMPIGSMASHGSVPGILGTPKSRKKRKLIVSGIPLNDESRFEAVKKWCESFGELNSITRAPSGDLYIDFRKAEVADTVCRLQARVYISGVGSVGLSWFTGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6A0</accession>
    <name>A0A401G6A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CWC25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0105700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608601.1">
        <property type="nucleotide sequence ID" value="XM_027752800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6A0"/>
    <dbReference type="FunCoup" id="A0A401G6A0">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6A0"/>
    <dbReference type="GeneID" id="38774605"/>
    <dbReference type="InParanoid" id="A0A401G6A0"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022209">
        <property type="entry name" value="CWC25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12542">
        <property type="entry name" value="CWC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="432" mass="50551" checksum="27129BBB39FBADB2" modified="2019-05-08" version="1">MGGGDLNMKKSWHPLLLKNQERVWLEEKKALEEKKKLDQLRKEKEEERQLQELQRMQEEQTGKKRQEKLDWMYTTPATGSNQNANDLEDYLLGKKRVDKILTAGENEKIGAAHKSFIATQYANTVRDTAMKIREDPLFAIKQQEQAAYQALMANPLRLREMQERNGIKAKKDKKDKNHKKKDKSSKDKHRDHSVSPYPERRRSLSRDRYSHSRRSPSPYGRRSRSPVLRSRYIDDYDRRDDGYDRRGRSRSRTPDSYPRRGRDIDDRPRDSRREDDRVRTWPKSDESDDNGYNSRPRRSRSREDDRKRRQYPSRSPDRHGSSFKRSRISPPPAVHPLSSQSSGAHNTGDDDRAARLAAMMTDASTMSVDRRERLTTLLEQEKAEFEAEERARARSKGMGGFLSHEQKKVFGGVGGIEERIRRGRGQMRVDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6A7</accession>
    <name>A0A401G6A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0105820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608613.1">
        <property type="nucleotide sequence ID" value="XM_027752812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6A7"/>
    <dbReference type="GeneID" id="38774617"/>
    <dbReference type="InParanoid" id="A0A401G6A7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8876" checksum="3EDC5FA0E10D289B" modified="2019-05-08" version="1">MGDKHLVAASMECFSVSAKNHGSKYLRVFAVANGRVFVKTQPFPHVNETYAAEEHNMNKTSSLGPQALCRVKCLEQTHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6P7</accession>
    <name>A0A401G6P7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0107150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608746.1">
        <property type="nucleotide sequence ID" value="XM_027752945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6P7"/>
    <dbReference type="STRING" id="139825.A0A401G6P7"/>
    <dbReference type="GeneID" id="38774750"/>
    <dbReference type="InParanoid" id="A0A401G6P7"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="6">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="241" mass="26171" checksum="B9F5D8D83A66BA43" modified="2019-05-08" version="1">MSAYVPSSAFQAAAAYMSGAPSLSALSDTIRLELYGLYKYLVVSPIPSTSRPSIFDFTGRAKWDAWRSIRQKYGDRANEAEERYLAIARGLGWSEDATVEQPSTSQEEEDIRDDDSVEASRQSGGLSMGNSVSVMAQPEDENSPDAVSNIAISGTAEDMESFLRANTSFKVDTKDVNGYTPLHLACDRGNIGVADILLQRGASWQVPDPDGYSAEELAEIADQREIVDLIGRAKSNRAGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G709</accession>
    <name>A0A401G709_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lactobacillus shifted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0108380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608869.1">
        <property type="nucleotide sequence ID" value="XM_027753068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G709"/>
    <dbReference type="STRING" id="139825.A0A401G709"/>
    <dbReference type="GeneID" id="38774873"/>
    <dbReference type="InParanoid" id="A0A401G709"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="140" mass="15127" checksum="D5EA6B659833CE02" modified="2019-05-08" version="1">MLARRLPRLARPLARLTSSAPASTSKPAPAHEAPSPEAVIPQSPNYPSTWSTSQSPRPQGQSGPRFEQTIMEFQPNPPSAMEMISQEPIRVVHGRKAVCDGGIGPLGHPKIYINLDNPGPQPCGYCGLRFQQAPHAGHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7M1</accession>
    <name>A0A401G7M1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0110370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609067.1">
        <property type="nucleotide sequence ID" value="XM_027753266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7M1"/>
    <dbReference type="FunCoup" id="A0A401G7M1">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7M1"/>
    <dbReference type="GeneID" id="38775071"/>
    <dbReference type="InParanoid" id="A0A401G7M1"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="427"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="865" mass="92559" checksum="BE71CBD45D7A8613" modified="2019-05-08" version="1">MLFDPETANDLRPWLVKALEPVCDAEPGALADYILALLKHNAPEAELRKELASQLEEFLEKEGPSFIDTLFTALRTKSYLPYSAASPSSGYLPSSTPSVDTGIPIPLDALLSPSIPTSPDRGRKRSIDHDDHEMRPPTKGPRLNGDGQFSRYGRNDSRSSWGGRGERGGRMAMNGRSDYVEGSMNGGMDVGMGHAMNGGMGHINGRGPQYRPPDRRGICRDYHNNGYCARGAFCKYSHGDDAVIPSQLFPMNGPMGVGSLPFVPMLPNSGIPFGMGGGSNAAYDPHERMDMRPIAGASSSMSGRPPNPRAPIIPRHGDIDGAMAQKPGELPVIQDLTPQGVSDDDLSRTSVPDGPSASDRRVPGPSNHERMMNGARPMGGSPDVDMVAPPMSPNGRFGGPRGSRMAGPRGTFGGDVHSFRPEKRNDKTLVVEKIPEDKLSLGSVNEWFKRFGTVTNVAVDAVNSKALVSFSTHDEAHAAWRSEDAVFGNRFVKVFWHRPMEGHGQMGVRMLAASAPLVATITSKDASPTQAAAGESSATPPATPSAPSARKPSTSSAAAALAAKQRLLEQQIAEQKSLMALLSAASPEEKKDIMARLRKLGEEMKPSASASQSSRPVPTLAPAAAPKKPRGVTPRSEDQERLERERLDKELELHHATGAIEGEVEESTEDLKVKLAKLKAEAASLGLPEAAESPYPSTSYRPYRGRGRGGRGFFRGAMRGGARASMKLDNRPKRLLLKDASGDNVQAIRDWYETTGQVETVDVMDNGDVLVAFRTRAAAEQGFSKGASIPTVGQVQISWYSGQQLAAAGAPKPPSPIESSYAAEDKRVFDSTVGFSGPTDDIHMHEEVAASGWGGDDGEDGFAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G844</accession>
    <name>A0A401G844_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0112300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609258.1">
        <property type="nucleotide sequence ID" value="XM_027753457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G844"/>
    <dbReference type="GeneID" id="38775262"/>
    <dbReference type="InParanoid" id="A0A401G844"/>
    <dbReference type="OrthoDB" id="3062869at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23272">
        <property type="entry name" value="BED FINGER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="66"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="14709" checksum="7747116B8EB0FA83" modified="2019-05-08" version="1">MYGSALSSISASRGTKKLSQKLSKLMRELSDDEDDTIPSPSAAATSSTQESSGDPNKPWLADFHGYLNSRDHLGDNTIVQWWGLNATRYPVWASLARDYLSIMASSVLSECAFSSAGITISKRHNRLNADIVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8G8</accession>
    <name>A0A401G8G8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRO8NT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0113370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609361.1">
        <property type="nucleotide sequence ID" value="XM_027753560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8G8"/>
    <dbReference type="STRING" id="139825.A0A401G8G8"/>
    <dbReference type="GeneID" id="38775365"/>
    <dbReference type="InParanoid" id="A0A401G8G8"/>
    <dbReference type="OrthoDB" id="3254501at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRO8NT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="12523" checksum="169DD4B518B1A7F9" modified="2019-05-08" version="1">MKLLGIIPYPWQQVRELPVLYRITGTITFMNEIPRVIEPVYHAQWSSMRRAVHRENRDRRLFQHMRFPPFDDEEPPLDYSDNTLDVEPLEAIQLELDKEEDAATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G931</accession>
    <name>A0A401G931_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0115320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609556.1">
        <property type="nucleotide sequence ID" value="XM_027753755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G931"/>
    <dbReference type="STRING" id="139825.A0A401G931"/>
    <dbReference type="GeneID" id="38775560"/>
    <dbReference type="InParanoid" id="A0A401G931"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="307"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="587"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="753"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="615"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="854"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="889"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE78643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="995" mass="107461" checksum="D2E48162E5B2CCE7" modified="2019-05-08" version="1">MSSKQSRHSSSTSSPSSPPSNHSSKLPKFLQKSTRDRSKSLVDPGHNASSSSSSSSSNSPPSPETSKAGRKASKKGSMLKEWEEEQHPVSPDVDIPQGGEVADETPVIVEPVNIPRPRTRSERPMSENYPSVAYYPSSSSSRLSDIPTRLSGWFSHTFSSSTTDLSLPALLSQQHLASSTSSPKGKGSALLTAARHGKGHIDKAMRYLLDSDSTPDKCSDPIWLLGVEHAGYEPPPAPPPFTASKRNASVGRRNSIDSRRSPSSVSSSASSPIAPSSFPGDPSLSQSHPTVLSPSKDKDPSRNWPPAFYADFTSRIWLTYRSQFLPIRDTSLSALESDVGEAVSNPSSPQPKKWNWPLVGEKGWTSDAGWGCMLRTGQSLLANTLLHLHLGRDWRRPPYPIYTADYATYVQIITWFLDNPSPLCPFSVHRMALVGKDLGKEVGQWFGPSTAAGAIRTLVHAFPDAALGVSVASDGAVYESDVFAASRSSRASLRRYGQTWGDRAVLVLIGIRLGLDGVNPIYYNTIKALYEFPQSVGIAGGRPSSSYYFVGSQADNLFYLDPHHARPAIPLRPPPRSAELPSLERWERQTSPGTLTSDYGPVRVPQHTRSPTAPSVRSSAGSASSVLSQRSPPVPSPLQQQQLSTSSSNSTSQSSSAQSHARWQSSSALPDDSELDSRDLGIGADLDPLQLHYVTAYSAAELKTFHCDRVRKMPLSGLDPSMLLGFLCKDENDWKDFRKRMNDLSHTHKTIFTIQDEPPSWPSDSDDNMGLESISEPDIDMPEDDDEDALDDDRSSSTSPDTSVSVQDGGAKSEADTEEDPVGPITPGAGKNSLDIPHPAKGTVPQPISRESSLDFDDDEDEEWMDPSTDTPPLSPDAEVPPPSPSSPPVQVYAPPLAQATSTGSTISASTHASGKKRRKFKSKKSGSGSGSALPEPQMQFPFPATQAEEPLSDAQLEETRSKRIPQMRTAKARDGGRTQSGGVRGVPADDMDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9L5</accession>
    <name>A0A401G9L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0200730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609789.1">
        <property type="nucleotide sequence ID" value="XM_027753988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9L5"/>
    <dbReference type="GeneID" id="38775793"/>
    <dbReference type="InParanoid" id="A0A401G9L5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="145" mass="14628" checksum="87BE5A1ACD48668F" modified="2019-05-08" version="1">MSSSAALPLPSAGAAPSPPIIDILRLAAHAASSLLSFLLALLAHLLTPALYVLAPALLFLRVLLDALVLAPLALARAVLREAYPLYVFGGAACLGAVCVGYAARAVAGWVLAASAPGAGVDAADAAPRAGGKRRKRVSIREEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Z8</accession>
    <name>A0A401G9Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0201660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609882.1">
        <property type="nucleotide sequence ID" value="XM_027754081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Z8"/>
    <dbReference type="STRING" id="139825.A0A401G9Z8"/>
    <dbReference type="GeneID" id="38775886"/>
    <dbReference type="InParanoid" id="A0A401G9Z8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58108" checksum="5199B620C365CD80" modified="2019-05-08" version="1">MLLDLFSPWGAFGTLLALISAAHVYSLCVIRLQKRSLPGPFGLPLLGNLLQLFPHRKHMLLYLSTLEERYGPLFAFNMPGYGRTIVINRPEWLEHMRKNEGTTYGKGDFILSIFQEFPGGDSAFGSEGAKWRFSRKVMKPIFVAATFDRDVSYCMNEVTLTAREALENAAKEGLIINFNDFCGRLSLEVFCKMALDYDMRLLTADASTLMEQHPLMKSLSILSEATSGRLFNPWWRFIEKFDGVSSQFTSARAEFFNVIEEVVQQRKSAGKDLKENHDFLSALLRNGQVQDPALLRDTLVTLLFAAKDNTQNSLAWSLYELSRSPVWLKKLRQEALSNGAPTQGVQYSNLESYPIHLAVFYETLRLWPGVPKNSRVALKDDMLPAIPEEGYGPVRVSRGEYLLWSDYSMMRSEHVWGPDAREFNPARHLDADGLFVKPPHPKFHSFGSGPRLCPGAQLAAYEFVAFWCSVLLWFDLVPVDDMTRLPADALTVTMRDPLMVKVVMRSPSTVPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAE3</accession>
    <name>A0A401GAE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0203140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610030.1">
        <property type="nucleotide sequence ID" value="XM_027754229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAE3"/>
    <dbReference type="FunCoup" id="A0A401GAE3">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAE3"/>
    <dbReference type="GeneID" id="38776034"/>
    <dbReference type="InParanoid" id="A0A401GAE3"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11536" checksum="393189988028CAB0" modified="2019-05-08" version="1">MAKAKAAPTSSSGGKAAKKKKWSKGKVKDKAQHAVILDKATYDRIIKEVPTFRFISQSILIERLKINGSLARVAIRHLEKEGQIKRIVHHSDQLIYTRSTGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAH7</accession>
    <name>A0A401GAH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0203580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610074.1">
        <property type="nucleotide sequence ID" value="XM_027754273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAH7"/>
    <dbReference type="STRING" id="139825.A0A401GAH7"/>
    <dbReference type="GeneID" id="38776078"/>
    <dbReference type="InParanoid" id="A0A401GAH7"/>
    <dbReference type="OrthoDB" id="2794288at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47238" checksum="79DFF47768683CE2" modified="2019-05-08" version="1">MHPRKLPLELSDHIIDFLWLDRSALVACSLTCRAWLRRSRYHLFRTVELCGEADCLRLENLLTSSLAASSGIPFYIRDLTIHSCNLVPGNKLPQAAKTSWMGRFLPKLFTSLTAVECLQLTGMDWQRDFQEARDAFLTSFPALQVIILDDVRFEESIHVLRLLASHPLLNTICMIDVFWIVESPFLVEGDQWAHAGKIGINELMVHDGVSDCGTSIAASVVDAPFKMSLTRLSWASSSALESVVKLGKVIEKAGPSLEDLSLYLTPESGGEAAYPADHISLAHLINLKSLSLKCCFAAMPTAKDTAYIPALLSQVCAARYIRMNIFLTDSPPIQLGLLDWESIDKTLASLGKRLPRLVVVLYIRPRYRTLGWADEVISAITAYLPESQVAGTRVRLLCSMSATRHPDHEQLREHWLSLYCDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAZ4</accession>
    <name>A0A401GAZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0205250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610240.1">
        <property type="nucleotide sequence ID" value="XM_027754439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAZ4"/>
    <dbReference type="GeneID" id="38776244"/>
    <dbReference type="InParanoid" id="A0A401GAZ4"/>
    <dbReference type="OrthoDB" id="3366139at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="448"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="266"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="613" mass="66161" checksum="B65665F5CD592661" modified="2019-05-08" version="1">MSDIYSALRVSPRKKRCPPDLDDNLLTPKKLRTAPPTPPPTITRRKAKGDATPLPSQLTHLYNAHTALQHALSHALATCAVSPSEDTGLVRNVLNHHSLATYSGLTHRFDVDDLKRLCWLWEWDGKQIPTAGSAKGKAKANDDDDNPFLDTPAVAFPAKDWTRGAMSFVINQTSHYSKSAGSRVPAYGIGIEVEMDIDKGMGGGMAAVARWTASSETRRKEFRGKLDRWLELHADQSPIPHVPMADLPALPVAAKPSTLTRLLASSSPKFPSSLSILTRPTSPSPSPSKSGLKSPTKKARDFAIPFPVTPSSRVGTPSKSSVPFPQTPSSRYSRKDSLPSLLTPTSFGTPASSRTSSPVRPETPTTGFRTPTSSRTPSLKRPDTPTSSASSSSVPTTPVHQRGVNAQTAPETPTSSRRQALYERVRQRSLTATPTKGGTPGTAGKMTKEQLMKLSQDEMRRRCLLGRLGGVAESVWMLFSNPGSSTSTPSARKRRALLTSEVAAAVVKSSPVPISSAEAYESLHLLTKLCPFFLRRLDIAGGEWLEMPAPSTGGADADAGASSEKLPASPGRALKKSESAEEVHTRSPRRVKREGGGLRDVRERIRRELEMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAZ6</accession>
    <name>A0A401GAZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Impact N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0205420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610257.1">
        <property type="nucleotide sequence ID" value="XM_027754456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAZ6"/>
    <dbReference type="STRING" id="139825.A0A401GAZ6"/>
    <dbReference type="GeneID" id="38776261"/>
    <dbReference type="InParanoid" id="A0A401GAZ6"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="218" mass="23424" checksum="52A95E287C4F5F94" modified="2019-05-08" version="1">MTAARNIAATSSLIHLTPSGNPPTSVQHRWHSSRPSSSESVSWPHAVASSETLTHLKSAFRAHASRLPSTYGDTGDTPSETGYVHEFIAHVEKTFPRTKRATHAMWAWRGSSPSKRTTGTADGSRAASVSSGSSDGGESGAGERLSRLLELSGCEDVVLVVFRWYGGVKLGSDRWKCISSVAKEALELGGFGLWGKTEDANNEQRSKGKGKKGKREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBK5</accession>
    <name>A0A401GBK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0207540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610467.1">
        <property type="nucleotide sequence ID" value="XM_027754666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBK5"/>
    <dbReference type="STRING" id="139825.A0A401GBK5"/>
    <dbReference type="GeneID" id="38776471"/>
    <dbReference type="InParanoid" id="A0A401GBK5"/>
    <dbReference type="OrthoDB" id="3358904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="179" mass="19466" checksum="CAC9698649E72C0E" modified="2019-05-08" version="1">MVQRPTRPTPYIGTIQMSNSQAHTEGWDQLLALPGPPTAGPPPVSRSPPTDYGVFVVNMLGRMTRTGGTIDQRVLRRCLGLSSSYLITDTTMNAEHGLNSWHTGFGRLIDVVVALHARGELEVETISKASKSCSECWTVAGLWKETDGSRESVKGVAIRLKELLDGGGKTYRGVRIYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC19</accession>
    <name>A0A401GC19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0208730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610586.1">
        <property type="nucleotide sequence ID" value="XM_027754785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC19"/>
    <dbReference type="STRING" id="139825.A0A401GC19"/>
    <dbReference type="GeneID" id="38776590"/>
    <dbReference type="InParanoid" id="A0A401GC19"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="37"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="390" mass="44279" checksum="C9883574D10F7301" modified="2019-05-08" version="1">MATIMARYNQNDDTLQRIDEVANEDVRMKDAFVPDAVYLVVDTNILLHYLAVLSRFSEDIEAHAFPVLIIVPNVVISELDGLKKREELLWFASTASTWLLEKVKGRKSVKVQARRETCDTPIADSDYARKNDLLIYDCCAFFRTKGNVVLLSADKNLCITCLANGIPSVRPSIQRWSSRELARSLLAELNYSHDVSYFRGHEDASNFRPSRTLDVHRRLTAAPVQEDEDGMDIDDDGAAGDSKEDFIPTHALDSLHMQVIDHFAIVLKDVALRVRTATGDLAPPSQSQHAPKYRQKDFRAWTIGDCLEYLDAKKRLGVSRPSLRVFLLRRNEDRGWRRGQDWSRQDWTNSLEALEDVGTVFEDGFVLNSLAALRPEVQNIFNTPMRPTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCI1</accession>
    <name>A0A401GCI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0210520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610764.1">
        <property type="nucleotide sequence ID" value="XM_027754963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCI1"/>
    <dbReference type="FunCoup" id="A0A401GCI1">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCI1"/>
    <dbReference type="GeneID" id="38776768"/>
    <dbReference type="InParanoid" id="A0A401GCI1"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="50"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="34074" checksum="7D1890C9B67E2A52" modified="2019-05-08" version="1">MSTLDPHFSFHIYPRFYPFLQLPPPNHLLPIALISSNLSSPTPITMTQSREDSVYLAKLAEQAERYEEMVENMKRVASSDQELTVEERNLLSVAYKNVIGARRASWRIVSSIEQKEESKGNEVQVQMIKGYREKIESELAKICEDILDVLDKHLIPSAASGESKVFYHKMMGDYHRYLAEFATGDKRKDSADKSLEAYKAASDVAVTELPPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQESDKPADKDEAGDAAAEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCJ8</accession>
    <name>A0A401GCJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0210840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610795.1">
        <property type="nucleotide sequence ID" value="XM_027754994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCJ8"/>
    <dbReference type="FunCoup" id="A0A401GCJ8">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCJ8"/>
    <dbReference type="GeneID" id="38776799"/>
    <dbReference type="InParanoid" id="A0A401GCJ8"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="774" mass="86494" checksum="F5C6458F49108599" modified="2019-05-08" version="1">MDPHSRFLQFNSRQPKSGPIASSSRYMDPVKPANPLDNFKRRPTPSRKSSTASISALYTSRPIATNSRVKQDEQYRNDMYLAFVNNALQQKTNGVSDAFDELVDQFNPRKSISSLASPTPQLRFWILALSHVVSRLDRPHFALVEAILSTPWTTMDTSFVKSYTAFIGMLVSAKPEYLSLVLGKIAQGLTYQSGFQALNAGPAEGSSSPITRRIVYDRVHFLLQHLISLVPTIPSAFQPFLVRNFPHKRQNLATQVTYIRNLLRITEYCSELSDRILATIVDRTIQIDVEIQVELEELEEQLANEGPNEVFELDPFDTLVGQEGEDTDSEDDDDEDGFSDLSSDAGGDIDDDDTPDVPSDFKQVQSMVDKLDAILKTIFDHFNRTHSSDPATSVGLSTPLSRSDSPLLPVEPLPPPSPSPVERGKLVRRQQFHTLMSIFDRTILRTFKSRYTQFLIFWYSSLDPEFSDLFQGTLVSKALLEEDQPAVTRAAAASYIASFVSRAQFVDRQSTRGVVALLCNFLRSRLDLFDAMMQTGAVLPSLAHHSVFYAVTQAVFLIFCFRWRDLLEDEEDVDEYASIGVPKKKWMVELDILQRVITSELNPLKVCSSNVVMQFARVAQATDFIYCYSILEANKRSDYAPASPAPTTAGPQLNARGPTIHLSMFGQSLTSELNTFFPFDPYKLPRSGSYIQGVYREWSSVAIDDDDEEEEEDEVEEVGEDEDDDAEQDAGPKGIVIAGVRRVAKDKEANDLGASFGGMSISPMYPSPLKATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDH7</accession>
    <name>A0A401GDH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0213950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611098.1">
        <property type="nucleotide sequence ID" value="XM_027755297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDH7"/>
    <dbReference type="FunCoup" id="A0A401GDH7">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDH7"/>
    <dbReference type="GeneID" id="38777102"/>
    <dbReference type="InParanoid" id="A0A401GDH7"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000350">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="98"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 beta-propeller" evidence="7">
        <location>
            <begin position="413"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="5">
        <location>
            <begin position="732"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115019" checksum="5F755DEB2F3E97F5" modified="2019-05-08" version="1">MSSPELNGLNEKELDDNLATDSPVELNEAADNDYDHTHSSGTSPELGANGVSNGHQNSHVDVTGSETEGEREGTDEEVDAEGSDEDRDDEEDDEEPALKYQRFGGIAHSLLQKDAGSALAYANQRVALGTHGGMVHILDLSGQHLKSFSSHSASVSDISLDITAEFVASASIDGQVIVQSLSTTETSTFNMKRSLRTVALEPNFAKSSTRSLVCGGMAGDLVLHEKGWLGYKETTLHSGEGPIWQVRWRDRLIAWANDLGVKIYDTVSQTRITFIDRPADSPRADLFKCTLQWQDDSTLLIAWADHIKVARIRARPRSVTTSASSHQPPFLAEITAVFQLDCMIAGIVSHPTPSISVPPPPDTASVTSAPSRHAPSLSTSSVAPPPSLTSFLILAYTPPDTSLLTGNEATMDRAEQARKAAERPDLRIISRAGEELAADALSITGFERWSCNDYVLVDIEAGTVVAGSGNAGERYYLVLSPKDIVVVKPRDWRDHVAWLVERKQFEEALDTIERQTALGLTLLPGEDTVNPVHIGQQYIEHLVGEGEFIKAAQLCPKVCGRDTKRWENWIFVFAQKHQLQTIIPYVPTESPTLGHMVYEMILAHFLAHDRQSLLQTIKSWPKGIYDIPAVIVAVQSELDRAPSSSSLSTTTPDSIILMECLAELYTTNRQPGKALPFFLRLRRPNVFDLIRENNLFTAVQDQALLLVEFDHELMEKRKKDGEDVDPAQSTAITLLVDHIHSVPIGRVVRQLQSRPYYLYLYLDALFNKDSHLTSDYADSQVKLYAEYAPHRLIDFLRASNYYNLEDAYNVCSERDLVTEMVFLLGRMGDNKRALTLIIERLGDVNRAIDFAKEQHDDDLWEDLLRYSETRPAFIRGLLENVGAEIDPIRLIRRIKNGLEIPGLKGALIKILHDFNLQISLLEGCQTILEGDCADLARTLHKDQTSGFFLSIKTICPICSLPLQQSSHSLILLYLCRHVVHADCVYDGDALPEQLDQNFVDMGLGGDAGIGGKIAFTAMVRAKINQGCPVCHSKSEGLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDM4</accession>
    <name>A0A401GDM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611201.1">
        <property type="nucleotide sequence ID" value="XM_027755400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDM4"/>
    <dbReference type="GeneID" id="38777205"/>
    <dbReference type="InParanoid" id="A0A401GDM4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="70" mass="7447" checksum="47DE028BEE22478C" modified="2019-05-08" version="1">MVVRSRISAKQSLGGSRANDYCEWVWDAAVVAQIYGAREGTCKPNLGFPVMGSGLGLRGVLARSMMSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDT0</accession>
    <name>A0A401GDT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0300630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611261.1">
        <property type="nucleotide sequence ID" value="XM_027755460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDT0"/>
    <dbReference type="GeneID" id="38777265"/>
    <dbReference type="InParanoid" id="A0A401GDT0"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="288"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="627" mass="69934" checksum="A0A51160D977C834" modified="2019-05-08" version="1">MQPWNSLTYQPHLLHQRFRTPSNLTSAAQPFASNPPCRTPIPPSTGQLTHPTPQNSLTPPQLSSCSSASVSSLSSSAAYPLLSCTGNILPSSEPQSYSRFDKFDSPTGMYQLVPGPCTIKRDDPRISTVAVGVSVAPSPAASAVDCHCTASDAHGILDGYSTNTSPACRLLLAAAEPLKMRILSSPYPATAEYLPHARMQGQNQMQQHTRIPNVYINGLPPNFPEDQLYAITREFGTVLSVRTFTRYGIDKLSPSDLQRIHYIPNMNTPGTHAPDSYKAQSTQDLSSTNLYMQDLPLSTDETDLAVLVRPYRIISSRIFRTRLSNPPGIIAFARLETRAAAEEIIERLDGRMVYDEHATPHRIQVRFADTNEQRKLKRAQYFIGREPSLAPFTLSQAANVNLKHSHFNPFLPQFLQSGLDLDMNASPCLMSDRHLVARGKSVIPPLLHESGMRQRQQLFARADNNLPELVTVPDPNDALGNHAAYATRALHDMQNLPYADSHLFDAEAHMQTAMSINMSNPFRAHNHFKRMEGPIVREHVQQQQAQLAQHAVQERPCRPSNLMACSNVSQDDFMASTVGAHHYVATDFTRPRHVGRHRNGLNFGLKNDFKQVHFPREQHQQYQTHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDV5</accession>
    <name>A0A401GDV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0300200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611218.1">
        <property type="nucleotide sequence ID" value="XM_027755417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDV5"/>
    <dbReference type="GeneID" id="38777222"/>
    <dbReference type="InParanoid" id="A0A401GDV5"/>
    <dbReference type="OrthoDB" id="445826at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="638" mass="70925" checksum="EC2E9EB51DC842D4" modified="2019-05-08" version="1">MSSFSLPLPSRPNIPYSRAGSPSLQTDSDDAVITGVELIIAELDHSSVQSAHTQFSQLVSDFNNTNPTQHLPPFQVHPGDPRNSVDYVFISLHPDLTPELRPDILEQVRKVFDGRSGLRAGWRTGSGTDQSRRVMFIMDSEQHARTMQPRLEKWMNDHGMTFQGCFLSKPSAGSFRITFDILDPTHVAQLRQQPPMFDRRTYPVVQSQFIPPIYSLQVAVAGCGEFQGIEGRLNTYIHRRYGNDAIAYSRMVLEGEVYTVVLKDWATTSRLVSDPFKFFSDTSIPHFISISQPILLYLLNSADVPLNPAFLSHSSPSTSPDQRSIQAQIDALCQQGLETVHTFSDVVKQQHAMIMELRSQGNHVMSAVSMVASSVSTSAQLSSVENQLGRLHDRRAQLEDKLILAPEPNAHQYIQSRIHSIDEETHELNDRAAHLRRGLQALASHIDTTLRLLPTPAAEHSTAQSLSQSSSGHLRPEIDSDEQQRYQPRPRMTPSPPGPQPDGMQTEMGSEAGKVRKCIVDPFFTLAPTYAINANGLANVSKMAAIANAITLRQPHAWIINETKLPQPQASRIRVNGYNTFEEPGLPLSTGRSRKWGVILGIKRSIHTQHIPTPPQLHGRAVILDAIILTEDGHGFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF42</accession>
    <name>A0A401GF42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0305100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611703.1">
        <property type="nucleotide sequence ID" value="XM_027755902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF42"/>
    <dbReference type="FunCoup" id="A0A401GF42">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GF42"/>
    <dbReference type="GeneID" id="38777707"/>
    <dbReference type="InParanoid" id="A0A401GF42"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13949" checksum="BBACDF167359B640" modified="2019-05-08" version="1">MCKHILNAQVAIRAPCCKQWFDCAECHAETQDHRLAKTAEMTLMCKKCRKAFRKDMSNYEESDEYCPHCDNHYVLEAKTPQAVLGVEGDDPRINARMLKDERVKRDPSRSLFGQDLSDRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFP7</accession>
    <name>A0A401GFP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0306740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611864.1">
        <property type="nucleotide sequence ID" value="XM_027756063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFP7"/>
    <dbReference type="STRING" id="139825.A0A401GFP7"/>
    <dbReference type="GeneID" id="38777868"/>
    <dbReference type="InParanoid" id="A0A401GFP7"/>
    <dbReference type="OrthoDB" id="2649303at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="1">
        <location>
            <begin position="307"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="675" mass="75922" checksum="DCC6377DE297C4AA" modified="2019-05-08" version="1">MDSSPPMAVPRPPSPLACKKARLSKSTCAEPCVTRQVSVALLALALVPCGPHLSTQTATDFGTIRDLMPPMMVHDRCTVIAPEFTTSLSMPMGHIMPAEALLQASLDELEAASHEVRMDIAKQSQSDRRTGVSYERHVRNYFFWWATFQQQETAKVPGRIAVPAEPITAAKAIMFLQYESTRPKRKRGSMDVQDGTTIGKSRIAQAISALESHRKNCEHLHKDVPDARISLRADQRICTIEDAVKHNEPLRIERAQALKAARTSSDTYSNIQLMNAATGFLNISSGVRKLVTHIRDRAMLTSSSTAFRGDNLRSLLWSDLSVCQIPMYDIQLGHKVPALVFMANNGKTNQNGWTDEFSAFHHCLVELCSIGSIALQLYSHFHIQNNTVPNFGVDITDRNFGEYGRRDWYWYHVFYASWPDAPMSYEAHRSRINALHLQHEISITKVTHAGQSFAAQNTRSHGVSASDTKALGGWSKSGSFRSCYDHELPVDALVGSAMFNARQLGTYFIPRDVLDPPLSLKTAIFPWLEDQEHVMRARAEAEALAKDITLVQFFRVLTWFRHVLLQDMAILYSWNPSTLVFQYPPFNTATFRAFTADAATHIRVAEEQSRLAFQHLPERFVTSVKGIVTGLELAQQRDHELNDARWNALSHDVSQLKTLLEEAVFAPVRRNCKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGW1</accession>
    <name>A0A401GGW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0311370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612321.1">
        <property type="nucleotide sequence ID" value="XM_027756520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGW1"/>
    <dbReference type="STRING" id="139825.A0A401GGW1"/>
    <dbReference type="GeneID" id="38778325"/>
    <dbReference type="InParanoid" id="A0A401GGW1"/>
    <dbReference type="OrthoDB" id="3219024at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="465" mass="50035" checksum="B2327D71FC5029AD" modified="2019-05-08" version="1">MPPRAHRPALTRTHSRSSSNGSSKMGLNLQITQKDPPPPRISDKAKKNAHLYHEPPARTTSPYPRTNSAHHLPTREQGPLRRPPASQALTSARTNGVKPKADFRISSPSEGDDDDEWVSSESGAATPSAGYDSEEGTATPVDPPKPPTVQADVVQKDGPPTPRAETPTLPRSDTARQVPLSPMKANFAQPVHAQQQQSKPQPTATERHDQRRPQVDVPSQSQQQQQPSPPVSKALSETHSPPRISSPDPPKRQSMTRPPSTHSVTSRSDAAPLRPHPLIRGHSYGHSGALPAKPATLAPLTVSSDAAQAQMSTVSSPSSLRADSPISIKTTSASPSTSPSSSQAHRQLRRTSTSSLRSMTSTAVPPSAVQAQLIKTHDRQRTMSAMSSTSSFAALSSLAMRSTPSPPRTPIHFTSHFPPAEQTSAVESVHPLLPPPYLSAHLTVLAYRNPIAESYDRVIRAKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGZ5</accession>
    <name>A0A401GGZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0311950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612379.1">
        <property type="nucleotide sequence ID" value="XM_027756578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGZ5"/>
    <dbReference type="STRING" id="139825.A0A401GGZ5"/>
    <dbReference type="GeneID" id="38778383"/>
    <dbReference type="InParanoid" id="A0A401GGZ5"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018811623" description="Hydrophobin" evidence="6">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="114" mass="11490" checksum="AA05974C57C6B8BC" modified="2019-05-08" version="1">MFPNFVVLALAILPVALAAPQSGSGSTPCNEGGSVQCCDVIAPAYTKNMSIVLEALQIVVESLSTPVGTGCSPPTPYYVGGGSVCTSDPVCCVNNYFGSVGVGCEPVPTPDGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHG1</accession>
    <name>A0A401GHG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0313490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612533.1">
        <property type="nucleotide sequence ID" value="XM_027756732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHG1"/>
    <dbReference type="STRING" id="139825.A0A401GHG1"/>
    <dbReference type="GeneID" id="38778537"/>
    <dbReference type="InParanoid" id="A0A401GHG1"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7801" checksum="99FB7F303AE4A957" modified="2019-05-08" version="1">MAGQHASGFNPHPPGFRYKFLATTLGASMWFFLFYRARKDGPKLLGWSHPWEAHGHEHGHEAAHNEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHJ3</accession>
    <name>A0A401GHJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0400130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612555.1">
        <property type="nucleotide sequence ID" value="XM_027756754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHJ3"/>
    <dbReference type="STRING" id="139825.A0A401GHJ3"/>
    <dbReference type="GeneID" id="38778559"/>
    <dbReference type="InParanoid" id="A0A401GHJ3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="541" mass="60125" checksum="5B8DB70ADF0A436F" modified="2019-05-08" version="1">MGPLHTHLTLLEESSARYASRPIFMVPRQPVHAEGIGKRDWYTITFPQFLQDVELAARYWLRTLNESATPLRSVVGLWVGGTEYTDVLHIFGVARAGFVPQALSLLLPNPGAAYELLSQTNAHALIIDPSFASMSTNCPIPVHIAVRDIHAMVMDVDDIALPPVHKASAAEDIAMIFHTSGSSSRRPKLVPCSYRWLDALIAKTKQGGITYDPRKQDVTAWMGSMCHIGQTFMVLGAMQHGACLVQPTTIAFSSDELVDMITRCGLNRLMQFSTFLGIHLRRARQDVAFLARLQSLDEVLYSGLPLSQEDKEWALSNGIVLRNLYGTTECGGSMLLSIGGRDSNAHLLRPLEGVSYRFCPVSDIRASNALDASPLLELVVLSDSGDCPHYSLRDVDGHFHTRDLFQEVSPGCYVFRGREDDWIKSENGLRCDTKAIEDEVRSTCKELVFDCVVVGTGRPSPALFVEGRGTVDAEALKEEILRRTQHSQAERYLHEQIVSTKFVFVVPPNSLPRTSTKGNIRRQAVEIAFKAELDEIYRPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHJ7</accession>
    <name>A0A401GHJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0313200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612504.1">
        <property type="nucleotide sequence ID" value="XM_027756703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHJ7"/>
    <dbReference type="FunCoup" id="A0A401GHJ7">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHJ7"/>
    <dbReference type="GeneID" id="38778508"/>
    <dbReference type="InParanoid" id="A0A401GHJ7"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="202"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="426" mass="46364" checksum="D8ACBD64F672549B" modified="2019-05-08" version="1">MTQTTLLQYEAPWPVYALDWCKTPAPGQQLRPRSAFRLGLASHTEDYRNRIAIAGLQDERVLVEDDYTEYPDFVTLVEANHGYPVTSLQWQPATAPSFAWSQKAATTELLATTGDALRIWEYTSDGQPAMSSYVGRQPTSSGHRLVTKIALAGQSKVQNHGMGAPLTNFSWNEKAPSLVVTSSIDTTCTVWNIDTSTAITQLIAHDREVYDVAWLPGSTDIFVSVGADGSLRAFDLRSLEHSTILYETPVPKNVQPPPASPSASARPLTSPLLRIAFNPNDSNYMSTFHMDGADVQILDMRSPGSPVMELRGHRAQVNALGWGSAASPLLATAGDDCQLLLWDLSSYTQLPSTSPRTTSTGLSSPRPDVKKRVVTDPVMAYTGQSEIVNLAWSPQIAGMAMHNGYSTAPGEWLAIAMGRSIRALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHV4</accession>
    <name>A0A401GHV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0401570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612697.1">
        <property type="nucleotide sequence ID" value="XM_027756896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHV4"/>
    <dbReference type="GeneID" id="38778701"/>
    <dbReference type="InParanoid" id="A0A401GHV4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="125" mass="14514" checksum="95A48EF8D0DD93FE" modified="2019-05-08" version="1">MEYPHPLLARRQNQFPFDLALLIRTYPVDDLRYPNHLSRLHPLLRIAVIPTGMDISPNKDHEPAGGHATDVEEIIMSATAPDDDEDHNISCGTRNVRRELMLQRSPLVARLFFFFFLFPLRYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHW2</accession>
    <name>A0A401GHW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612675.1">
        <property type="nucleotide sequence ID" value="XM_027756874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHW2"/>
    <dbReference type="GeneID" id="38778679"/>
    <dbReference type="InParanoid" id="A0A401GHW2"/>
    <dbReference type="OrthoDB" id="2984747at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="472" mass="51083" checksum="512E3ACD1D1B04A8" modified="2019-05-08" version="1">MYEEVCLLCGKPVNVDGRAYCSDECESLDTTSRSDSATSSAFTSPYLHSMNGTGILPDVPALVPSALGRSVNGRSALMHAKNRLSISSSSNSSVTWDTFTDDDEDPSNFGLHSSNGDDDFHHAEMLSADVGSSKSPGPMGQLSYVRRPSSTNNRSTIPLLHRRTSSISSPSNADDSAAQSAFAPTFSAEDDYSDVPSASISSSSSARSQGRRLRKSAGGDWEKDPETITAKSKRNRASLPAYFSLLTSAASPTSVRTQRLPSSIQTLTAISRSLQSSPPTPRVANPILDPTIAYAQHTRALAVEAAPRGRGRQRDPNARSPSCAHRSPGRSPACHVRHTRVEAQMRARLDSVEKVADWVSNSPVVGAQVRGRTLTRRNSSPPPKPRHEMLLADAMLDPDVGGQLDHLREALARSLHVRVEEERVEHGDDRRGRRRAEELDNIPQGVDRSAPGYGSGRSGLRARERGRPFPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI38</accession>
    <name>A0A401GI38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0402300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612769.1">
        <property type="nucleotide sequence ID" value="XM_027756968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI38"/>
    <dbReference type="GeneID" id="38778773"/>
    <dbReference type="InParanoid" id="A0A401GI38"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9559" checksum="06E23B00CB6DC35C" modified="2019-05-08" version="1">MPAPPRCTSPASQNGLVDTSHGLFQNESNLVYSPKISSTTIIPVAYYRTWIRISISEYAMPAGLALQLFFPAIQEQLSELRGFIGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIN4</accession>
    <name>A0A401GIN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0404080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612945.1">
        <property type="nucleotide sequence ID" value="XM_027757144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIN4"/>
    <dbReference type="STRING" id="139825.A0A401GIN4"/>
    <dbReference type="GeneID" id="38778949"/>
    <dbReference type="InParanoid" id="A0A401GIN4"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE82032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8655" checksum="1FD69FEC0BF8B298" modified="2019-05-08" version="1">MPAKKRCQLQAEPRCNSAVLRLVGQCPHCRAEFCGAHRMPEHHNCQNLESCRQQAFEKNKAKLESERTVASKMAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJJ1</accession>
    <name>A0A401GJJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0407030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613232.1">
        <property type="nucleotide sequence ID" value="XM_027757431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJJ1"/>
    <dbReference type="STRING" id="139825.A0A401GJJ1"/>
    <dbReference type="GeneID" id="38779236"/>
    <dbReference type="InParanoid" id="A0A401GJJ1"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="205" mass="23304" checksum="742CC7C88D29EF7D" modified="2019-05-08" version="1">MPTPPPQLVFSNDIAHMDEWARRTGIPLTSAEALGTNYARARRWLLSIRAQLVQNFGWCDITPLDPRLLFDIECPSPYRSSRGLPRSPNMRLQIPANASSFFSRERRVQWEMVFHSALFPGLRHTVPAVADLLHLLQCLLTGMLVLVKEEQVPGGGLERTIRALPPVEWVHSHESMLTESLGPTHYRQLFRAAGDNRIAFNLERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJV8</accession>
    <name>A0A401GJV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="11 12">3.2.1.106</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0408350</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="11 12"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613364.1">
        <property type="nucleotide sequence ID" value="XM_027757563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJV8"/>
    <dbReference type="FunCoup" id="A0A401GJV8">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJV8"/>
    <dbReference type="GeneID" id="38779368"/>
    <dbReference type="InParanoid" id="A0A401GJV8"/>
    <dbReference type="OrthoDB" id="410058at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.110">
        <property type="entry name" value="Glycosyl hydrolase family 63, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031631">
        <property type="entry name" value="Glyco_hydro_63N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038518">
        <property type="entry name" value="Glyco_hydro_63N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF11">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16923">
        <property type="entry name" value="Glyco_hydro_63N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 63 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="13">
        <location>
            <begin position="247"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE82451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="757" mass="86048" checksum="518F9A05619865AC" modified="2019-05-08" version="1">MTGLMWFGTHDYQSIARTRHACEQEDHLNSYTWTEYDARQGGSQIVKDGMNNVILTTEFLKIPGGQHGGSWAARIRGEPMNQALPSRISTIFYMGLEGLGGLDMESEEAENGLEGPVTFSGSSPELDEFTIRIVDGPDNEAVTVGPHSSVFADRIGKSHFAGLRASPGRIWQAKELLVQSLLKHAQDAALPYKDQSNGMPDPSFVLQLPDEVYSSSNLFALQKSFDGPFQFDVFFESASAKQKLSTATLDEGLPALKASYEQRFDKVFPVPVSYPTTNFDSLRAFSKAITSNLVGGVGYFYGPSIVDRSFAFEWDQEDGDFEDSDDNEEKGARLTEPQELLTATPSRSFFPRGFYWDEGFHLLHIGEWDNDLSLEILKDWINLIDEDGWVAREQILGEEARNRVPPEFQTQVPSFANPPTLTMAVTAFISRLKASSPEITDRDLGMDLGMGAQVPISETHLAPGSRYLQSPELALEYLRSIYKPLKRHYDWFRRTQRGQIKQYSRRARSRTEAYRWRGRSQQHVLTSGMDDYPRGPPHVGELHLDLISWMGFFTRTMKEIAEYVGEADDALAFEEIERAIIDNIDDLHWSEENQMYCDADVDDEDESYHVCHKGYLSIFPFMLGLLPADSPHLGAILDMVRDPKQLWSPYGLRSLSVSHPEFGQGENYWKGPIWIQMNYLALRALYKTYGAQEGPYQQRSKEIYTELRRSVIDNVFKEYERTGYVWEQYDAVTGEGRRSHPFTGWTSLITLILSEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKA7</accession>
    <name>A0A401GKA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0409790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613508.1">
        <property type="nucleotide sequence ID" value="XM_027757707.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GKA7">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKA7"/>
    <dbReference type="GeneID" id="38779512"/>
    <dbReference type="InParanoid" id="A0A401GKA7"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="80"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="1006"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1425"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="715"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="779"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="868"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1493"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="508"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1288"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1381"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="912"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="934"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1571" mass="174861" checksum="9D9CC848BA983891" modified="2019-05-08" version="1">METLFRKKKSGPRQSSVTANDLNERSLRPLSSTSVATVRSEYNRNSRYTPSVSPVEQHHHFSSFSQQLHRLTTTDGFYFARPDNDEDIDALFQNIMRLRDLGDMPSLSIDQKWHIVYNDEQLRWKEEKQREEQAKKQHDIGQPQSIVEGTPEWYIKKFLDKTVSAKQASRLQVSLRSNELGWFKHFVSIQGTSVLAQTLHHISRKGAQRRKDDIDLEYEVAKCLRQILNHPSGTKDATSHSMIVTQVASSLNTPNIPTRKIVVDLLSFLVYYNDGQAHHMVISALEALSAANNEPGNCYAYWFKSLENALSGRGKMGTLVGASEEVRRHGGVDSSLNDYTLSNIILVNGIIDGVDDLDLRVHHRSQMEAAGLQRITTLCHSFGVSSIETQLQMLQGNLEEDERRLKERIDQEILRDLTNPEDVYNALSAKIEDSKARDYFLSMLQHLLLIREEGPALVHYYQLIDSIVTDVVLDKKLAGAEQRLGHSVERVIAQFNEADRYQQAEDDLAKAHAAVLRLGLEKEALEEEIAQGSDGLVGSLKAKVAHLEEKLRVSRENTSRLQGQLEAQKTGYEEQIVQLETQIMELFRMLKEVGKGVNKIFDNAGAMDRKTLIETLEKHFQRDRTISILEGRDKHRRRVADDRTAARDNAEVGEDNERIPPKSGSLRRPGRSSVKDQSKPPKPAGYADVANGHTSQFMDADDAIVQAQIQQQLAEGAIYPRRDGPSSSPRSIRGSPKRKELYRPDYVISTSKLNNILAPAVDHLEGSGRDSTLLNEPVDEQDVESEFGHPSSSRSGPSVPTEATSVSFYSDGSRLPVPGSLADQLRNHFASKGRLPPEQSPHQSPTLTTVAEETPSIHTGAQLLAEDSSSLGGFSSPPSPPLPPPPPPPPPPPPPPPTTYRATDNASTSQLSPPPPPPPPPPPPPPPHLLFTNYTASTYTASTPGAALPPPLPPPPPPVDRAPIFSSAWPTYNSKAVTSPVPGSAPGSTRSSMLGANISSILSARKDLSITPSTKMKQLQWDKLPQQLVAKTVFHEEEPLKEQEWVRKLQSDGVWMEMEEDFKAKQLVINLMAKQKRAELKSVLDPQTKKRVEILIQTVKRLQPEEIAMKIRHFDQEVCTQVFLSELKPVLPNPEQVGKLNVYRNAQPEELAGLHPSDRLMVQLIKIDRLGPRIEGMLYKRVFDETWSLLDDSARKLSEAGNALLHARYFKELLSLILLIGNYMNGTGVKGGAFGFRVSSINKLVDTKSLHNTTLLHFLERTVNKHFSEMEEFLDELAAPAEAYRVNLQDVRKSLAELRQGLKEIRQELADHFADMEQNDKYGKQMWTFVGKATAQLEDLVDDANHAGAVYSEVVKYYGEDEKSMNSSEFYGIFKTFVTSYKKCKADNQSITEERMAMEKRRQAAEESKAMRQKAAEEMASQEQEDTSVLDNLLEKLRNGDSVGRKVRRARVGTVTRPTPPLTLNTEVLLATAGGDDTADIARDMLARLKSDGFDITMPGSPTARQSRQRGGFNGSKGIVQGLENGISETERGSSSHKDCSLVEPFGDASSTVGSVTDSELTLVVSTNDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKZ5</accession>
    <name>A0A401GKZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0412320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613758.1">
        <property type="nucleotide sequence ID" value="XM_027757957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKZ5"/>
    <dbReference type="GeneID" id="38779762"/>
    <dbReference type="InParanoid" id="A0A401GKZ5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="8777" checksum="F316BD21DBC819FD" modified="2019-05-08" version="1">MGVNMNDYRLKIMCVEGQLSIMNVDYRLTRMSSQFRGMTHILLLDGLLTTRAFFQHALMSQRIHHYRRLSRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL17</accession>
    <name>A0A401GL17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0412430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613769.1">
        <property type="nucleotide sequence ID" value="XM_027757968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL17"/>
    <dbReference type="GeneID" id="38779773"/>
    <dbReference type="InParanoid" id="A0A401GL17"/>
    <dbReference type="OrthoDB" id="2801804at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="382"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="881" mass="101699" checksum="76AD68E9DDEF93F3" modified="2019-05-08" version="1">MRGKFIVMPVNKFMDTFAPESEVMAKKPFKPNFKKAFKEMENVLEGTVREEQMYKPLVKCVQNYKLCKGYVLKLVQNKPDKADPSRQKVDAALFLPENAKQRKTFDDSRPHWALQRLSIEFKKHRTEDDPFEDPKTKGEDEDNLHHDSEQGDEVQVDDVHDANDDDVGDMDNVFLDEDETYGDGDPTMEDDEDGDEENPLQMAYGNSSRETFETAYEPPADRRAAVRGQIISYAKILFSRQHRCFAFTILILRDVARIIRWDRAGTVVTNKFKYTNTEYLGKFLWRFCNMTDKQQGYDTTAVAVKCGSADYKLMEQLARNPPEGAGSEYARESFAKSMPNLSKENPNDWSCWKLTVHPENGKATDGSDPRPAGRNARKKPRLQHFLVGKPHFQASGMTGRVTRGYIAYDCQDNKFVFLKDVWRVDLPDIEKEGYILQSLNDAEVANVPTLVCHGDVLDVEDVGNVVHVERQRTKTDTYWHEFYSGQMNPIKTHTHYRLVVEEVCRPLSDFRNSLELVMIIAHCIKAHRQAMKKVRITHRDISAGNILMNEKTATINGRQVPIRVGILSDWELSKQVEDEDDETEATDKETGGNSQKARQPDRTGTWQFMSAILLDRPTRAVEVADELEAFFNVLLYYLIRYTNSNIDDPATFMSQYFDECTINAARTLYTCSMAKRLVMKSGELMVDVNTSVEFQYRNGKKHPSNELIRKLLGWFKARYAEFSLEDWPQQAARRGPPVDHTQRMDEESENDVSADDQDMLVEEYLRHQMKAQSVAEGMSEEVYEMEPYFDEKAREMQKGLANNLKTHDQMYNLFQKIFCEEQREWPKHDKIPDRVSSNYNYARYKEKGLELPAAPIAPSGSKRRLEADLQCSRQSKRSRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLJ8</accession>
    <name>A0A401GLJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0501030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613971.1">
        <property type="nucleotide sequence ID" value="XM_027758170.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLJ8"/>
    <dbReference type="GeneID" id="38779975"/>
    <dbReference type="InParanoid" id="A0A401GLJ8"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1370" mass="145848" checksum="620CAB96EFB4F5C6" modified="2019-05-08" version="1">MALAAAAAAASLRADADFDRGLQSSVLDLECSSPFHLHILLLGLSASLSGQSVLKTLSVASPGQKRAFSSAPSLSAGSPYGPSRERYRCCYCSPLARRPFPERARRKRQRIPRRTSARCRMVKKRRSVQSLFATVVQLASAPDSPARPASPSPRTHARTRTRSRASSAATLSPASPSPSSSSSRFGSVSSLPDLPLLELGTTRRHSPPPDLLDSDPFANLSPAPSERSPRLPPLDFSDAAPVSPLRSPLASPVLPRPAELVRPKSSGQAQSAHTRPAFRPRPSLPSLNTLAQSHVVVPKVPRGRVGAQLPAEPWAEPEPAPVLETKRRRHMRRPTELSVIRDSRMMVDVQLEVGPEGDAAETSSVASTRSCESVAADVPFATVRSQPGPSGAVSPCRDVVFLPSGSVSSSSVSPSRDAVYALSGTVSPPSDAAYALSGTVSDAVFPHSGTISPPSRTVSPPSGTVAPPPSLCPPSPSSTNDFLTIDGDLPSPPPPRYTRVLEEDLFASLDYSYAHALSALARTPSPALDPTRLAKLVAEPGTSADTVRALARPALGSHSRSSSSAASSDCDYGDALGADFGYAWPPFPARAAAAEFWEDDARAKMTRFSRRSSSSSTGSRYSIRSVEGPAEGSESGEPVDGGEGGARRGETNGGGRYYGGSSGSYGNGRSNGYYGNGYGNGYGNGNGHTGGNGFGGAGGRDGRDGDDGRNPRATPSLSTPSETEDDEEEEDEGDGDGDESSDDFVTALDFGGDDLSRRPSRSATPSRHRPAPPSHEDDVPLAQQIPSALKAQRTIRRQVRDEIDQRRQVRPARHVREAPQPPPPMPPSPSFKSAPAPAPAPAPAPVPVPAPVPPPPAYPARSANRPRTKTLPGNASSPIAVGELTKKLMGLQARSVLPAALTRKRPSVDLHPKALAPPDFPPDTSISSSQSYGQNADLALLQRQPSRVATESSGEDARGRSNSLRPSRSFHRSATPAADARAYANSGSGSASGSVGRSRSVARTRVPVPQEPMPAVPTLPPSSPRLDEPSGAGVDRARSLRAPSRRASPDRHPGERDRSRARKPSSADAQQQQPAPPLPAGFVPGHAAAGSYSQPPPYQAKAPAVWQQRIFVGNMQRFCLVEIGAATTAGDVMQVVDAQGGLEQGGSGSGWMVWEVSQDFGMERPVRNFELLSDVCGSWNTDRTVNFLVIKRTVWANMLSRSAVPSSSPVCSGYVQHEYKRGKWQKRWLELREHSLWLSKRDTGKDQTFLCSLNNFDAYIFARPHKAPKQYVFAIKSTDSLSFFENTADYVHIFSCGESEGRKWVEKILVARSYVLYQERNVLSSAGLSRVATRPGQRPAQPLVNVPQKLDYSSSSIDFEPGSLLGRRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLR7</accession>
    <name>A0A401GLR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SRF-TF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0501730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614039.1">
        <property type="nucleotide sequence ID" value="XM_027758238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLR7"/>
    <dbReference type="STRING" id="139825.A0A401GLR7"/>
    <dbReference type="GeneID" id="38780043"/>
    <dbReference type="InParanoid" id="A0A401GLR7"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="337" mass="35195" checksum="896DB4DB505011D6" modified="2019-05-08" version="1">MPADPTSPTLGKRQRGDNLPSAPHDDGFVADPDAQESGGDDDEDEEKPKSDKKAGRRKIKIEFIQDKSRRHITFSKRKAGIMKKAYELSTLTGTQVLLLVVSETGLVYTFTTAKLQPLVTQPEGKNLIQACLNAPHGTLPSSLPVGTPIGRSAMSMGHHAAPGSANVPGGLSIAGQAPAPGAAEDTEEAPAEEDTEHPPERRSKRRRASSSAANNANNAPNASPRTAGSPTLPVVQPPQGAPGAQQQQPPPSPHRAMPPLPVNIPPAPAPGQPSPAPAGQPYPQYAHPGPQGDPAMYTGHPQGYPAPPYGFPPQTGHEGAAPWGAPPQVQGGHYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMG2</accession>
    <name>A0A401GMG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SCP_0504180</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614283.1">
        <property type="nucleotide sequence ID" value="XM_027758482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMG2"/>
    <dbReference type="STRING" id="139825.A0A401GMG2"/>
    <dbReference type="GeneID" id="38780287"/>
    <dbReference type="InParanoid" id="A0A401GMG2"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="20">
        <location>
            <begin position="211"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GBE83370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="385" mass="43093" checksum="7875CBF7013E96D4" modified="2019-05-08" version="1">MAQRRRQSTAQDIENTSVGHSRFLAEASRKEKWKDTDAAGDSGNDASQVAADDLQSTTDGKGKLSPTSSHLFKLILPLGHLRTCSKASQLQSRTSSPSSVVAKLPPPTIFLLHPSQPLSHLSRLIAASLAPATPTISFRSTSPGGKTYQWSDSTDVADFIRDAARTTEFEICVEDEQYTQVAGSREGSAGTNAHPSQDARSSIRVEIPSFEDRTRFLRRRLTVIEEDLKRMEDLKRKCDTEADRGARRMAMGGFGMLVVYWTAVARLTFWDFGWGVMEPITYLSGLSTVILGYLWFLYQGREVSYSSVLQRSISARREVLYQAQGLDIDRWTDLVSEAKRLRKEIGEIAEDYDEHRWKVRDETKTKTQDSHGEPEPALARKGAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMW5</accession>
    <name>A0A401GMW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0506320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614490.1">
        <property type="nucleotide sequence ID" value="XM_027758689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMW5"/>
    <dbReference type="FunCoup" id="A0A401GMW5">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMW5"/>
    <dbReference type="GeneID" id="38780494"/>
    <dbReference type="InParanoid" id="A0A401GMW5"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE83577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="303" mass="34658" checksum="E275649E858E683C" modified="2019-05-08" version="1">MSAGPSAAVNVLHDLAEAAEEFVEKMTSTEDEAETEGNKEGEGKMTVEERKAKMDQLRKKMRSSALANRASVIEESTKAKVTAREAARLERQRKLAEILRTKADAEERGEDVERQKNWEWTIEENDEWEKKKARKARRADYEFHDDAHAARRRYKKDLDLIKPDLVAYNKQKEIAMGLAPGTLVKSSNGPSSLNDFDPKAGSSMQLVPTSQQQQLAAEYLYRDANSLLYADNKPSEEAIDRVVGKINRDIDKKSKFSRKRLNEDEGDITYINERNRVFNKKIARYYDKYTAEIRASFERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN54</accession>
    <name>A0A401GN54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0507030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614561.1">
        <property type="nucleotide sequence ID" value="XM_027758760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN54"/>
    <dbReference type="GeneID" id="38780565"/>
    <dbReference type="InParanoid" id="A0A401GN54"/>
    <dbReference type="OrthoDB" id="2751476at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="160" mass="18004" checksum="BD188F7B49ED5E33" modified="2019-05-08" version="1">MGMPFLRLLTPSITPVVRKPIKQHDSRSMANTNPRNWTTANQPMTQKQAACIARLAFYQHINMNIAHLRHRISKADASELITMINAGRVPSQQHLLALGQQQIIHPQDPFTLGHANNLATHGQRTYLTELLTERGMVVHIRDDLTVAEASVVIAALRKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNB0</accession>
    <name>A0A401GNB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0507610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614618.1">
        <property type="nucleotide sequence ID" value="XM_027758817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNB0"/>
    <dbReference type="GeneID" id="38780622"/>
    <dbReference type="InParanoid" id="A0A401GNB0"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03038">
        <property type="entry name" value="GST_N_etherase_LigE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="328" mass="37577" checksum="8125FEAC12408C40" modified="2019-05-08" version="1">MNGRTRPLPSVVREFDCTGGTIIAYGHDTYTEPLRTDTTDYYQNPLDMDGVSHCSRDVTMTRATIERDPDLYRHRSMSNVITLYDIPSRDIKDNAWSPNTWKTRFSLNYKGLPYKTVWVEYPDIARVCQEIGAEPTSTSEYDTPKYTLPVIYDPSTKTVLAESAKIARYLDETYPDTPVLIPRGSSALHAAFQYAFAQMVSQPALPLMLPATNNILNPSSEAFYRRTRESWFGKLEDWSPPGPIREKHWEELRAALARVAGWMALDDEDKPFFMGDTICYADITIASILVWMKRVLGPKSQEWARVKTWDGGKWGSFMQAFDKYEMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP12</accession>
    <name>A0A401GP12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Farnesyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Geranylgeranyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0510010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614855.1">
        <property type="nucleotide sequence ID" value="XM_027759054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP12"/>
    <dbReference type="STRING" id="139825.A0A401GP12"/>
    <dbReference type="GeneID" id="38780859"/>
    <dbReference type="InParanoid" id="A0A401GP12"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE83942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="38173" checksum="7845326CA0BA3623" modified="2019-05-08" version="1">MASDSSTHQLDVLHILSEDSTWTETNESVLLEPFTHISSIRGKEIRGHMIAAFNQWLQVPEDKLDVISRVVSMLHTASLMVDDIEDDSQLRRGIPVAHKIYGIPQTINSANYVYFLAYQALFVLRSGIGPSSELEMEGKGKKRLIPFRELDRIVTAELLSLHRGQGLELFWRDSLQCPTEEEYVSMVNNKTGGLFRVAVKLMMACSTTNVDVDYVPLVNLFGVYYQIRDDYMNLQSTEYTDNKGFAEDLTEGKFSFPIVHGVRADTSNRQILNVLQKRPSTPTLKKHTITYLRDHTKSFDYTVTVLKKLESQIREEIARLGGNPGLEQIMQILQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP70</accession>
    <name>A0A401GP70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0506090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614467.1">
        <property type="nucleotide sequence ID" value="XM_027758666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP70"/>
    <dbReference type="GeneID" id="38780471"/>
    <dbReference type="InParanoid" id="A0A401GP70"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="358"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="777" mass="89058" checksum="AFCD03CB951A5402" modified="2019-05-08" version="1">MPLTTANPAETPNHHSINLNSSCVEATNADSSLDEPEDLRLSHFENEWYAKTSEDYILGPMPTAQFLDFLPMKNMARMPTACGAFNHLDEWDMASGLRHSINSHNRCPGFVFQYNDPEDEEDQPALIMRMNSDDDDVPREYCELFIDIQKDEHGDFLCDPPPSVDGARHDFLRILGHVHKSKRQKARQEFGRNVCWATDALVNQHRLHYFSVAIHGTSARLLRWDPSGLVASAAFDLHEKPEILCEFLWRFAHASTVERGYDPTVEPASKNEEYRFKTVLSHYLCVQLGLSLRNDSLDSLSDSDRIILQNSIDKHYDPGHVAAVSIVEKADKAGVRQLKRCLVCRPVSTYASMRRGCMRGFWGVVDRAIVFLKDTWREWSLTDQCEGDVLEELHKAGVRHIPQFSGMATFQRTTRSRSNALMNTPAFQRTQTDRYRMAEWLCRSDRQILVRSRVHYRLILTTVGLPLQDIRGTEELLHATYDVYESIIDARVKAKVFHRDISIGNVLLFKEPGEDIRHGYLIDWELSSHIRDDGLSESDWTVGTQAFMSHRLDTGNGRLRHTIEDDMESLLYVVLYCGLHWLPHELDADKAVQAIFFNREVVSRNESGRTELRSMEPGEGKLQNKKNRKYVDPSRFAEPFGVWLETSMNYNHPREEEDSSASNAVSARENGDCSDAAVSPNPCEGNWDGPTPWKLYWEQYKANEYLPKNDKKPHFNKYDESEAKPKDVTRVVVHRAGIPPNKRKARHQREPADGDLMHRDGEPANGRPAKRARISAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPG2</accession>
    <name>A0A401GPG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614995.1">
        <property type="nucleotide sequence ID" value="XM_027759194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPG2"/>
    <dbReference type="GeneID" id="38780999"/>
    <dbReference type="InParanoid" id="A0A401GPG2"/>
    <dbReference type="OrthoDB" id="3011415at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="435" mass="46877" checksum="356A770F15CE3D3A" modified="2019-05-08" version="1">MAKCAHPDCYCQRYDGIDDADVGPNDPQLCRQCKHIKTAHPDGSEQRSEGPPTIAALLDGLKNRSGVASLPGSRIRTAASSSTAAIQVSVEDAVKETNSGLKRQPIDTMTAGPSKKAKGIKATDTSQGKIIKIGHVILLPDGMDEDGNLNTARGPTHPQIARFVKYGLACSHKDASLEFRTGWNVKRINMWFAQLLPEAFEYMRTKVDKDDVPWVLCERPSANSLAIVDDTPVDGEVLNEYKGGNGRKWTERKLYIASKVEIPHSVYTNNWIAPAVDASDDDASSVGPSESEFLPQNLKGKGKMVPSATETHHNAVIELSDSETLPTVKEILAAAESGNSPPPAMVEELLVNGSDDNASSRANSPAVEGINAPGAPLDVDHSNDADPATAAGVNDGIHEKDWEAVFMARGSEHKNPYLQLSDDLLETKDNPWDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPM7</accession>
    <name>A0A401GPM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0601300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615065.1">
        <property type="nucleotide sequence ID" value="XM_027759264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPM7"/>
    <dbReference type="STRING" id="139825.A0A401GPM7"/>
    <dbReference type="GeneID" id="38781069"/>
    <dbReference type="InParanoid" id="A0A401GPM7"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="95"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="21221" checksum="F593F0A0438005B9" modified="2019-05-08" version="1">MIRFDNLPPEVMQAMCTPMHLILPPSPSPSARTGALFLGSFSAILDPVLLESNKISALVQVLDAPWLPSVDAHAKHGLEAYRLDILDSTSADLKPHLEATVRWIDDRLRKGVNVLVHCQQGVSRSAAVVIAYLIYTHNMSYASAYDLVRRKRACIKPNSSFVRCLQEWEQQWHHAEGRPVMRRASTTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ31</accession>
    <name>A0A401GQ31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615258.1">
        <property type="nucleotide sequence ID" value="XM_027759457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ31"/>
    <dbReference type="GeneID" id="38781262"/>
    <dbReference type="InParanoid" id="A0A401GQ31"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12074" checksum="A06F90EE0AB819C5" modified="2019-05-08" version="1">MVMAEFDESLEDTSLEVEKIIKANFESLIIQSTDISFPFAKGTMYLDNPKTVSWPTVPSSAELGRTLHPTPIGASHLSHSLGNKDGSSNGSLSVAETTSCTAKPRPKSTIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ68</accession>
    <name>A0A401GQ68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Efflux pump FUS6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0602780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615213.1">
        <property type="nucleotide sequence ID" value="XM_027759412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ68"/>
    <dbReference type="STRING" id="139825.A0A401GQ68"/>
    <dbReference type="GeneID" id="38781217"/>
    <dbReference type="InParanoid" id="A0A401GQ68"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="573" mass="62310" checksum="421568FB7D4E53BE" modified="2019-05-08" version="1">MAHLQDLTTEPSKPDTVEDTVTQVVLTASASDHHARDWRFWMIFVCVTFAQFLTALELASVTTALPSIVDALHGEQFVWVGSAYTIAITAFSPLSGNSAQIFGRRATMLVSLVVFIVGSALCGAATSMNFLIAGRAAQRVGSGGIQVMCQIIVSDMIPLRERGVFNGFMAMSFIVASIIGPVVGGSLAQHGQWRWLFYLNIPICGVVALVVLLFLRLRTPPGALSEKLQMVDWIGNLLVIAATTSATIGLTWGGVQYPWSSARILVPLILGLCGLVAFLVFEAFIPKHAIIPYAVLRHRTSASGYLQIISLYIAIMSLLYYVPIYFQACKDASPITSGVDIFGLAFSIAPMELLAGFSVAKTHHYRPQIWTSWVLVIIGIGLFSTIHVDTPLSHVIGFEIIAGAGVGMMSALAFFPMLAPLPVELNAQALAMYMFIRNFANILGVTISGTVLQNELTKHLPSALAQQFPQGSAIAYSIIPLIKTLQEPLKSEVQLAFTASLQDVWQVLIGITGFGFLCSLLMEHLPLHTGVDEKWGLEDRDNARQQSHEMENRIGASPEDCNSLCNRSRQAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQA3</accession>
    <name>A0A401GQA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase spindle elongation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615328.1">
        <property type="nucleotide sequence ID" value="XM_027759527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQA3"/>
    <dbReference type="STRING" id="139825.A0A401GQA3"/>
    <dbReference type="GeneID" id="38781332"/>
    <dbReference type="InParanoid" id="A0A401GQA3"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="87824" checksum="2CF6734A25E0EA0D" modified="2019-05-08" version="1">MATTTTITSLLNSLHTHLQSQTQLLPTLHAQLGLPPTALTDELAVLQQQLAQCVERQIDIRRRQVDEWTERCEAVEEGCRRYGRALGGHGKATGGSVSEIAKEQVLPRRFEVGSEFHERLRQLYHTKLEQLLTITGRLEALSHTLGPNFYAEDIIEPPPASGENEEDPSAHRDVTPERFSKLEKELVRGKGEVTKRLTQLSATMVQIDWLYTELGMAPPMLDDLPSSSSSMLGVPAMPRSTSSCSSRASHTTSSSGSSDPFLSSVSIPCSTPTPATRSKPLPPLLLLTVPDAPAEPDDTAYQRIFSRFVARMEEASDEDLASSVRIEGIEPTPGLLAWAETTRAALEDVKRRREAHIQTMYDQLEALWRRLGVPEADMDAFVEMQRGSTEITVRAYEEELERMLELKRERMGTFVENARVEITRLWDELMVGEEEKADFAPFFDDEHTEELLAIHEEEIRRLKEERRAKGPLLAAIRKYFEICEDEKELAAAATDQSRLLGRGSRDPGRLLREEKMRKRVTKEKPRLEQDLLVSVPAWEAETGCIFLVHGQSILQILMETVGAADKENSDKRGKSQGRGGSAPPRAKTPSNGTRPPSSTHYMPMPGSSHIGKSSSVTPAVRPGSSMSNSSNKRARLGESTSTYNNGAAHLNSSRGPDGHRAPSPTKIRSKTPTMAGSSLPRPIPVAMPVPRPGTVHHALGHGRVPSVQPHPHSYHPYSAAARTVSSATTLAHHAYGAPPLNSHAAARKASRARRESFKPRPSVDENWTGLTVSVADGGRRWAGFSGSVVKEEEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQC5</accession>
    <name>A0A401GQC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0604050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615339.1">
        <property type="nucleotide sequence ID" value="XM_027759538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQC5"/>
    <dbReference type="STRING" id="139825.A0A401GQC5"/>
    <dbReference type="GeneID" id="38781343"/>
    <dbReference type="InParanoid" id="A0A401GQC5"/>
    <dbReference type="OrthoDB" id="3215905at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="62022" checksum="FA2A50C672816DE4" modified="2019-05-08" version="1">MADRHETFRSPPTTTFSGVGLSASPATGDMPLPQSSSLTLPSPPSEMEAKFYYAGLPSAPVLVARTSTTRWEAPTGPEAYRKLKELRAVGNHALKEAWEGNLALKLHALLDSMKVKWTSTDIVRIGNSGESSAPIILWIGVMPASLSGDDGVVVASKCRELLVEYDIVDVDVEIRESVVTRWAGPELFTSTYSSDPTVDVRARLTTTLGLPICAQSTPWSEGTSGFFITEGGNTERLLLVTARHVIFTPDKNENKHFERKNDSQRRYNVTLFGDAAFNKYVESIKAESGGKALIAQYQERRIRAIEGKNDPAANKERQKAQAELDEVREAMEELNTFYQDVSTRWATPESRVLGHVILSPPINVGVGSSSDEGYTEDWAVIEIDASKVDASNFNGNAIDLGTRIPADEFTHMMYLNPRSAHSFTYPGDHLLRLKGTIPDEEMRHPTALDENDDPCLMVIKRGNTTGLTVGCANDICSYARKYYDDDKAKTSKEWVILPFDSKSGAFSAKGDSGSIIVDGLGRISGLLTGGAGATPSSDVTYATPISFLLKRMQDNGLRKPNVNTVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQF8</accession>
    <name>A0A401GQF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0604370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615371.1">
        <property type="nucleotide sequence ID" value="XM_027759570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQF8"/>
    <dbReference type="GeneID" id="38781375"/>
    <dbReference type="InParanoid" id="A0A401GQF8"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="198" mass="21926" checksum="03F0C7225CBA4788" modified="2019-05-08" version="1">MAAPAEMTTLDMSGHFTMNTSLSDDFDTILRLQGVGWFTRKAIGLSTLHLHYSHYTEPAPDAPALEYLDVAQSLSGGIGGTCEPRVLDWALHPYEDDVFGPVVFRSRRLHLRAPPDGFDLGAFLLDGWAEDVHVHGAVYTIAESAAARGGRAWRAVQVWGFKDVNGERRHARHIDFTGPQGERVLTKLVYDYHGPVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQN1</accession>
    <name>A0A401GQN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614967.1">
        <property type="nucleotide sequence ID" value="XM_027759166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQN1"/>
    <dbReference type="GeneID" id="38780971"/>
    <dbReference type="InParanoid" id="A0A401GQN1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8532" checksum="176602A198666B6B" modified="2019-05-08" version="1">MWLLDLKNGKYGIDKLCRLRALLPAYRKAETYLSSSLPIMPYARNTTAERLSNVPVMLSTNFVQIYAVSVSVHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQX4</accession>
    <name>A0A401GQX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Homoserine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0605910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615525.1">
        <property type="nucleotide sequence ID" value="XM_027759724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQX4"/>
    <dbReference type="STRING" id="139825.A0A401GQX4"/>
    <dbReference type="GeneID" id="38781529"/>
    <dbReference type="InParanoid" id="A0A401GQX4"/>
    <dbReference type="OrthoDB" id="195231at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="7">
        <location>
            <begin position="72"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="207" mass="22416" checksum="7FC447D982D97645" modified="2019-05-08" version="1">MMSHSFTVRVPVTSANIGPGFDVVGLPLSLYLTLSVTVTPPALGDPPHPPRLLYTGEGADELPLDAYKNLTTHVALYVLRCHRALPRQSLHPRGQIPFGRGLGSSGAAVIAGVLLADAVCSLNLSRQRVLDFGLMVERHPDNVTAALVGGFVGSYLRELDHKAEEAALVPLSKVLPEYPPDEDPRQLVEMPDPEEPKMSVRRSRFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQY3</accession>
    <name>A0A401GQY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspyridones efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0600920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615027.1">
        <property type="nucleotide sequence ID" value="XM_027759226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQY3"/>
    <dbReference type="GeneID" id="38781031"/>
    <dbReference type="InParanoid" id="A0A401GQY3"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="66"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="458" mass="49411" checksum="085F53EC708B48BB" modified="2019-05-08" version="1">MASIKSARTLEDTSETAPAEPKVPRRDFEEQKSDADTRTVSAEQDSFPEPPTPSPPGWDGVDGGPLGWVQVVGSFFLFFSSWGIANTFGVYQTFYEEDMLRTTSPSTIAWVGSLQGFLMMVIGILTGPIFDMGYSRALVWVGTFMVVFGMMMTSIAKKYWQILLAQGVCVGLGAGCLFIPSVAIIATYFVKRRSFATGVAASGSSIGGVIFPIVFHQLQPRIGFGWATRVIAFISLGTLSISLAVSRQRTVSQSRRKLFDPTAFKDVPFILYTAAMFFAFMAMYTPFYYISAFALGRTGADVTLQFYFLPIINAASTFGRIFPNFLADLTGPLNMLIPCCFATGVLALSWISVHSVGGLATFAVLYGFFSGAFVSLPSPTLASLSPDLKKIGTRMGMMFGITAIGLLIGTPIAGTLIDLETAQFVHAQIFCGVVLLSTVVLLVGTRIVSAGPKLWVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQY5</accession>
    <name>A0A401GQY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable inactive dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615538.1">
        <property type="nucleotide sequence ID" value="XM_027759737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQY5"/>
    <dbReference type="FunCoup" id="A0A401GQY5">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQY5"/>
    <dbReference type="GeneID" id="38781542"/>
    <dbReference type="InParanoid" id="A0A401GQY5"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="369" mass="40766" checksum="B33E2999834332B9" modified="2019-05-08" version="1">MSSESAPKLFQPIKVGDMTLAHRVVLAPLTRYRANAAHVHGDLAVEYYAQRASIVGTLLIAEAAFISAKAGGFAHVPGIWNEAQIAAWKKITDAVHARGSYIYIQLWALGRATDLQVLEKEDPSFPYVSASDIQLTGKPKAPRPLTEEEIKEYIQMYATAASNAVHGAGFDGIEIHGANGYLPDQFLQDVSNKRTDKYGGSIENRARFLLELLGAISAKIGAQKTAIRLSPWGEFQDMRMEDPVPTFKYVVSKIAEMLPDFAYIHFTEPRVSGNLDRSVKDGETNDYFRKVWAPRPIISAGGYTRETALAAADETGDLIAFGRAYISNPDLPLRLRMNLPVAKYDRDTFYTPENPKGYIDYPFADTAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRH0</accession>
    <name>A0A401GRH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0700080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615741.1">
        <property type="nucleotide sequence ID" value="XM_027759940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRH0"/>
    <dbReference type="STRING" id="139825.A0A401GRH0"/>
    <dbReference type="GeneID" id="38781745"/>
    <dbReference type="InParanoid" id="A0A401GRH0"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="618" mass="67081" checksum="40B1B67A54FB0B34" modified="2019-05-08" version="1">MSLPSEDKFARLNVSRTGIFLQKACLQHRYIRSKDNSNIVERPERLRAVHIGLAAAIAHLEDAIASSGDPLSKPGATHAANTTPDPDELASALGKLKLSSASSLAAQDQAYRIPVSFVHSSASVDILDNPAVKFIHGDIERDVYLEDLKTWAQDSHDKIAKGESELPDHLPQGDLYLCPASVDAIQGALGTVCEAVDAIISSASPPSARNPEPMDFTRAFVAIRPPGHHCGEDTPLGFCFVNNVAVAAAHAHLKHGINRVVILDIDLHHGNGTQSIAWQINEESYRKTLEESYVSPSGESSLQIYYGSIHDILSYPCEDGKVDLVQAASVSIHGSHGQHIENIHLKPYSSERQFWGELYAGPYAKLLGRAGNFLDGTGGPGNDVLVFISCGFDASEHEHASMSRHHRRVPTTFYQRFARDAGKFAERYAHGRLVSVLEGGYSDRALTSGAMAHLTGLLNLDDSEINQNWWSLDSLVQLESATKKRRAGRASLSKATEPWLERALEIFASIDSSHLLTPSSSRVPIPLSSRTLRERKKGSSSADPTPASSPPRKMGPRKSGGADKKDAVPFILPASVSEPADLKKYATAPVKSDRISEEKKLPRVILRLGPRSDAPLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS23</accession>
    <name>A0A401GS23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Serine/threonine-protein kinase gad8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">SCP_0702270</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615954.1">
        <property type="nucleotide sequence ID" value="XM_027760153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS23"/>
    <dbReference type="FunCoup" id="A0A401GS23">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS23"/>
    <dbReference type="GeneID" id="38781958"/>
    <dbReference type="InParanoid" id="A0A401GS23"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000003">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn], chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0186">Copper</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="224"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="481"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="GBE85041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="823" mass="89854" checksum="5C93F79A840A74E2" modified="2019-05-08" version="1">MSWKLGKSKKQPTLGVQDSDIAPRSSTPTPANPTGKPESRSGLLAIRVLWAEDLAIPRGTSMPPAVQAALSSQQAKVAASMSPSSVTQHRLATRRSNRDSVQRTQCWWLPYLVMEFEVNQVLITPLGGELSKPLYMYETNFDVSRHSEISIQCYLRTEEPKRGGDGIADDLGNDIFMGGVRFTPDFDDASAQDQWYDLLGGFGKIQIGVAFKPSSGHSLTIDDFELITVIGKGSFGRVMQVRKRDTSRIYALKTIRKQHIVERGEITHTLAERLVLARVNSPFIVPLKFSFQSEQKLYLVLAFVNGGELFHHLQREQRFNEERSRFYSAELLLALEHLHELDVVYRDLKPENILLDYTGHIVLCDFGLCKLNMKDSDTTNTFCGTPEYLAPEILINQGYSKTIDWWTLGVLLYEMLSGLPPFYDESTDKMYEKILKDPLVFGDDIGQQARSILTGLLTRDPSQRLGVNGTDEIRRHPFFEKNIDFKKLLQKKIQPPFKPSVSSPVDVSNFDTVFTTEEPLDSVVEGSQLSQTVQAQFAGFSYDGTNMPKLFEGIIFGPHELGSAFTLKNGDLLIAAANDDLLGFHHRRHCRQITEIATIISHPGPPSDIRANPPASLSPRTARMDTLYRARQNKQPLVLTALGTLAAAFLIWAAFLRPGTPPAAAPIVTKAVAVLKGDAGYSASGTVTFTQAAPTTPVKITGQLSGLDPSALRGFHIHASGDLSSGCVSAGPHFNPLGYTHGAPSAPVRHAGDLGNVVSNAQGVVTLDFEDAGFSLSGQLGVVGRTVVLHAGTDDLGKGGNEESLKTGNAGARAACGVIGLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS75</accession>
    <name>A0A401GS75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0702610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615988.1">
        <property type="nucleotide sequence ID" value="XM_027760187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS75"/>
    <dbReference type="STRING" id="139825.A0A401GS75"/>
    <dbReference type="GeneID" id="38781992"/>
    <dbReference type="InParanoid" id="A0A401GS75"/>
    <dbReference type="OrthoDB" id="3363891at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="673" mass="73535" checksum="244B3E4E76B2B8F2" modified="2019-05-08" version="1">MALTATAQSALPHSRGPVWNEVIVPTLRKRLKDESKILAKRISAASIGSGDDHSSDYQSSAFSTPPTQFSQYQRPSAIPRPSLQHSRNGTDSSQATPSPPQTFHRARTYSQPYLFDESGVLLPEPTPSRSNSPMINGTTTRIPVSRGRAGSSSSHAHGSTHGSIGRPEGSGHTYIESSDLYPVDESLHTHSTRSTVRIPPAQGSRLFREHAPFGSVRSIDYDPPRLSSDSEERPFEHWYRGDVSRNGGVGELRVGRREEMLDIASYGHTFRNASSRAALSSYSRSRSNSRGRDTESHTGMRSRAEGVGATTRESFYLDEDEHTQDMDMVLDEQPLTDLESDGYADQEEVLDLYSEQDVLPHPNGTVSSPSLTLSNDISGHRYAQQSVSRIPMPSTRHISPPPRTPTPTQAMRSMSEASTSSATSTPRSEQPSRMQPSPQSQTPVKSAPSTAKRRAKSPATPGSATSSKKPKTKPPPSSMQKKLQLKEEYRRSVGVYPAPDGDNVVDAIPSWTQPVPSGNWDDVVLPVVARKKGLDGHYATADGNPRPKPKLAVYEPAPGTFGYDHSKYRPPNANMAPQDIPMDEFGQKKEVESVLNPEPTHQPSLAPKPSPEPDRARLRPSPPPSPPPFSHYAENNDETTLHVTQFPSPPRRKAKDGRADDDGGAGCCRCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSW2</accession>
    <name>A0A401GSW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfatase-modifying factor enzyme-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616173.1">
        <property type="nucleotide sequence ID" value="XM_027760372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSW2"/>
    <dbReference type="STRING" id="139825.A0A401GSW2"/>
    <dbReference type="GeneID" id="38782177"/>
    <dbReference type="InParanoid" id="A0A401GSW2"/>
    <dbReference type="OrthoDB" id="2272314at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786:SF74">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45786">
        <property type="entry name" value="DNA BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="1">
        <location>
            <begin position="128"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="582" mass="65942" checksum="FC4F08DB55BAA5BD" modified="2019-05-08" version="1">MEVPKNNEDWSTPASIVVFQSRVHEWLMQFYRDINSGKITLMRKLARVLFMILEHEAFHAEMLLYILLQHAGTGTLPPTGFSPPVWSTLTSGWDHNLLLAISTVTLGPATVMLGHGDDKSEDACTSVHAFGWDNEHPKGEVHIGEFKIEWRPITNGEFYEYYSSKGKEAVKFPASWVEVEGEVQVHTLYGPIPMSVAKHWPIITLYDNLTMYASVKACTAADHDRVPAIANPPSPANACNDAPPEPPLNNQQIAQRACREHEYQAAQADAPQHRQSAERGLMWARQPYVEPVTRHDLGHMDVVCRYCNALHWRNERVISKSMQTNPAFSMCCNHGKIDLPAPLAPPEFFRYLFASPEPQAEDFRDNIRQYNAALAFTSLGVKIDDHLNNGWSEPVFRIHGELHHRHGSLLPQERQDPAYAQLYIYDPRDALNQRMQRNSNLRRDTMECLQGILNTSHHYAHVYKHAYEVLAGRGDIEDVVIRLCLLPTTDQCRYNLPTADEMAVILPGDGSEDVGKCDIILRHRNGPLQRISEGNAAYSCLHYVLFYPYGEHGWHFDMTLHESDTSPAYPHGLLRVSGSNPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT47</accession>
    <name>A0A401GT47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616324.1">
        <property type="nucleotide sequence ID" value="XM_027760523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT47"/>
    <dbReference type="GeneID" id="38782328"/>
    <dbReference type="InParanoid" id="A0A401GT47"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19728" checksum="D8F1AC046255D320" modified="2019-05-08" version="1">MHAGTSLEDLDLGLRAATASAVRHLNIGHCTALRKLTLRWVPDISLAEILRIISPNCRLHKLDILMWPGEVDCEWESAAHILDEQRFLTLREFRLNVQFVEIAEEEKRRISDCFAALRRRGVKFRLFFNGQQYRSDLPTISACQSKTPELQVEDGQLPGVPLTSHDDVHQSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT65</accession>
    <name>A0A401GT65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0705460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616272.1">
        <property type="nucleotide sequence ID" value="XM_027760471.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GT65"/>
    <dbReference type="GeneID" id="38782276"/>
    <dbReference type="InParanoid" id="A0A401GT65"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000268">
        <property type="entry name" value="ATPase 4 plasma membrane-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1906"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1941"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="12">
        <location>
            <begin position="256"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="13">
        <location>
            <begin position="721"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE85359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2450" mass="272664" checksum="2BDAE98C3DB814C7" modified="2019-05-08" version="1">MQAEECILFFAILAPPTFSPASASQPPEPAIHLIKMSNLSPMPLTDQIAGVLELMFRRKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELEWKWPPPFGESEIRIDQPATLVDMHGRILAWILPRVLIPDRQTKMLQATRALHPAIAASKPSSTTASWRHNPLYFLPPEECAQFPAGSLCLSPGWFQQPLQHMESGRLETSASLKLEGGRSWLRDIHDSSALLGTILAVVHPTLYAAGCQCLGLIQQDPELREMVLNWSSPFNALQVIANRETPFHRDSKTRYTFYDLLVTLGNYTCAWLKFPAMRVAIDYSPGTVIAFCGKAIRHGVTRADGERLVYAYFMREGVQNRLGIPAPHWMQASYYASHIGMCTRDIMPKTDGDENTMQGMETVDGSFIGGTKLAEVMAKSQGVVITDDSVWLADLEVGGDGGEMYSVEKLCNKSRLVVDLDDEVEFVTKVAKQTTRGVRYVDVPLSMPMGSNVPSPSKSPSKAPASGSLFNLDDGDVLGNIGMPIQLDLAARKTKTQNDFMRDWIPHRDDYLHAIVEMEAPPEPKNCAECKRAPFHRIEHWQGQYFEPASLYRVGVCIHLGHGRDPCPLGAFTAHNNPAPVVAPGSNFWNASNEDLNAHDGEVSDDGEVPFNFAPLAGTLDGEARQTDDAPDPTWEEDVPLVLSRPPRRDSYGNRIIVIVDISGVHHIGVDWCQCEMAVERDMQLLQMGLYPGTVKDPHTAFTFAVLDDFLLENKECKTAALNYYSKLKRVTSNAFPGTVPDRYRELMRVSRQWRQFKYRKWHGFSHDALHPVEKGGLAIFCPACPQPGLNLPFDWQADPVQWKFKCGFVMDGNFSAEHMKMKHPEEDVALSDGQAFMVGQEDYKAHLAVAMESHQRSTCHEHRAVNQANVDRANLDATGIGATACARHGFFVPHTVIDFQKGERQMNMDYSLSNALLTLTGITLILIMYDIMCQYGVHVCKRFRHSAYLRMPFELKVDQGIGLFHVHGHQDCCFQRFSPNFIVGAGMVDGEIIETLWAPTNEVSGSTRGMTRAHRQEVLDDHMNDSNWKKTTRMVPTLMTKWKRVLLGFPRSKESFEALSASTDEDVLEAWQKEYDDAMEARQNDPKIMDTFDVQLMKAPGKDLTQLRLAGEESAKGLEKGTAGWLSTGLKIQEAQLKLANDIRKVGQNPSVAEDLKTLERRQHLEVSILTFQRRSEKFMGRLEDVPAMEDRDDGALWDSLDENPFQIHLEDAEYGEDVIPPERASLNLPSQIGFVTAVANGLQTLAAQELELRKGLMNDILHELRMVLGLKSYLYRKRVHPANSVRTMTCAQAEVYAADQTVLACARLYSANRHAIMRLDTTDEDLALYRPLDKKDLHVKTAVIEASTSGLRNVNLAWFWTMDVAGDRGSSEWMDEFYRVNWLHARAQYERWREERVLVHSEMAWTIATFKQNAERWAHWLEMTDPSWRGHVCYAARQSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPNHFTKVRWEEGLHREMFAVRGICGDLALAGHADHIDHGRVIASVLTVCTFNREVLRPISIDVKAIPRPTTLVPHPKNLLEDSPDYWWKWDHQVGPAGSPMEAWWYKLGDPWEKVYTISESTLVQLEQLHVCIVNLTSWLHERTDQNLNVVLEELQEVTRQLHAKVSTDLYDKEKVDLETIIVEDVFRLLQCDDNGSMMEEVQRHLELFSPNKLELEEQNAFLQSQQARVREAECVSSVSCGTHCPGVMEAAALVAIALSNGEHQPPDWQDFIGIVLLLLVKVKVKQDGTWQEMEFAGLVPGDMVSLSLVTFYCTGGLLSDGGHQCLHRSSCSHWRVVFSHAASLIGQDDDTTGHLQKILAQIGSFCLVVIGIFVLAEIFCLYAGFRFQYCHGLNNILVLLIGGIPIAMPTVLSVTLAGGAQQLAKYKAVVTCITVIEELAAITILCSDKTGTLTTNKLTIDHETICTYGPFSAEDIILLSSYASRMENQKAINTCIVFAISDPSRARAGIKLLDFMPFNPINKRTEITYHEESSGKLKCVTKWLEADVKELASCGLCTLAVAYEEVDGDDPEGDGNGFELIGILPIFDPPHKDTKQTIDDVIALGVRVKMVTGNQLTIAKETGCCLSLGDHMYPAQVLKDGPAPGSKHASLDQMILDADSFAGVFPEHKYEIIKCLQGLGHLCAMTGDGANDAPTLSRANVSIAVEGATDAARGVANIVLTEPSLSTIVHAICGSHVIFQYAVPSATALTTSTTYAPSSPSPDGSRLRAATQCVNREALNRCMPAALSVVGTPVVEDMQTGAGTPVAEDTQTMEDMQTAEDMLNAEDSWIMEDSLSVTMAAVLADEEWQFLTGTARTFSVDLSFLAMFDLGECEHEWGAMGRAACVRLSMTQLANLLLLAAPYWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU23</accession>
    <name>A0A401GU23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0802280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616619.1">
        <property type="nucleotide sequence ID" value="XM_027760818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU23"/>
    <dbReference type="GeneID" id="38782623"/>
    <dbReference type="InParanoid" id="A0A401GU23"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="100" mass="11329" checksum="5E6D4584528BAC9B" modified="2019-05-08" version="1">MQHMKILSGLDFLSGSTSPMPWFFRIHPNNTALLALALLDTRLLDTLCTHLTNLLLCMARRRAIHQVVHDPEWSMDSLLQRALSCIVQTNTTIERLSEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU42</accession>
    <name>A0A401GU42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616651.1">
        <property type="nucleotide sequence ID" value="XM_027760850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU42"/>
    <dbReference type="GeneID" id="38782655"/>
    <dbReference type="InParanoid" id="A0A401GU42"/>
    <dbReference type="OrthoDB" id="2637363at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11386" checksum="DB5E2C1F6A0CDF3F" modified="2019-05-08" version="1">MQDEQLLQDAGEQSRSDSETDSSDGSDADSDAVDNHGSPRTFRGMARALQKAADEDSDDSDVGEVVEQQSSSAGIPPRCIRCFFRRKRLFTIKKLFNWSVEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUJ7</accession>
    <name>A0A401GUJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616818.1">
        <property type="nucleotide sequence ID" value="XM_027761017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUJ7"/>
    <dbReference type="GeneID" id="38782822"/>
    <dbReference type="InParanoid" id="A0A401GUJ7"/>
    <dbReference type="OrthoDB" id="2847449at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="125" mass="14309" checksum="1B669B3BDD9B2E4B" modified="2019-05-08" version="1">MVHIAGAKTARAMWEQLRTVKEQRGQHGILELCRHFYWMQAKEEDNTPCHITQLRQIQEQFHLMGKVVSDKDFRLILATSLPESWVLSSALTLAPKALTTHERGERGQSLDQAMVAKGKKRPFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV24</accession>
    <name>A0A401GV24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0805760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616965.1">
        <property type="nucleotide sequence ID" value="XM_027761164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV24"/>
    <dbReference type="STRING" id="139825.A0A401GV24"/>
    <dbReference type="GeneID" id="38782969"/>
    <dbReference type="InParanoid" id="A0A401GV24"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="120"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="321" mass="35665" checksum="391788B36C45591E" modified="2019-05-08" version="1">MQPKAPSGHADLTRSRKWDEDTILGPGDKIGEGDTFLVEDILPSDLANVAFDNLIKEVQWNTMYHRGGEVPRLVAVEGAVAPDGSEPIYRHPADESPPLLPFSPTVARIRDRVEEVLKEPVNHVLIQHYRDGMDYISEHSDKTIDVVHGSHIVNVSIGAERVMTLRTKKDARDAHAHEAANGRYARAVQRVPLPHNSMLIMGLATNQKWLHSIRADKRIPTLKSAPETAFDGARVSLTFRHIGTFLTPDGNHIYGQGAKAKTREEAREVIRGGEEAEKLIEAFGKENHSTEFDWEGTYGEGSDVLHFEVKDRSEHGTAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVD0</accession>
    <name>A0A401GVD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616617.1">
        <property type="nucleotide sequence ID" value="XM_027760816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVD0"/>
    <dbReference type="GeneID" id="38782621"/>
    <dbReference type="InParanoid" id="A0A401GVD0"/>
    <dbReference type="OrthoDB" id="3258969at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="919" mass="102916" checksum="8B0FF94CFFB2766B" modified="2019-05-08" version="1">MIILTRARFAKRLALRLSKAKRKVPAKAQPHQHHPESATTRRFVQGVPPDEVIAVTARRMAKAERDERMDITLALTEVKEYMGGFTRPRDLSASRWFRGGTYDRRGTVYESPPEAAYESHTVFIVESRYPVVHGIGRIDTEEQFVGVCREGDLPALLASFNSAKTRGEFREAMDNARWPWMQNHPMPRKTVWWEPGESPDAVHRKAIEESTDFASELQDGKRVPVELLTPASSSYDARSHLKQRRSFHASALARAGDHSSSSSSPSSSFQNRDKSLPASSWSRPPRPPQDADDNVVPAFYVERKRQRDDISERKVAESSLMAELNAGILSEGLSASVRPREEKIPVEVRMADGSVRHPSGFEPPTAETDFHPVAAKTPTEEDPQSILSTVKQMWDARKFAEPEVPPISIDADVEAEYLKRKVQDIIDNSAVRTAQIAEPASAVNFDPVSGVSSTPESPSTTSSWDTPARSRARSTDPDNIVPPYYIERKQQRDSISQRKEEDELMSELSAGVLSDGIAAEMRLRDEKIPVEVFEEDGIVRHPSGYAPPTPETDFYPASAKSPESPPKTLWTELTASKIARGFHWSALVRAQEVPDSFRLVSPVLGTSPPTPSSLHVRDIATTAQGESSDAVSAHDKPPQAEKDGDEYSLISTNPTRPRISYEQLDSRLDAIRRKYRPKLETEPFWRPLLTVTLATRPLALSFARLARALPRGEPFYASIVPDDRKCWKSFPTRMRQLRLRRARQLTIEMARFLEGYRGGFVGLRFGTGDRGRGIGGEGFAEPIPASKRLIQVGVGEWYKHAADLQELLREEAREADLDNVAVFGLDERGARTDGKAWAPKPRPLPRLESLNEFAAKKGVSFEGMDKWQREEARMEFAKKYAMQIAARRAQGHSSVMHPPPTHGRTLVRRTWQPATPIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW91</accession>
    <name>A0A401GW91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0805580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616947.1">
        <property type="nucleotide sequence ID" value="XM_027761146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW91"/>
    <dbReference type="GeneID" id="38782951"/>
    <dbReference type="InParanoid" id="A0A401GW91"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="145" mass="16018" checksum="80ABBBC2D97FF870" modified="2019-05-08" version="1">MVSQSLPPFYAHPSVNPKGSLHFTLLLLPNLAQTLLNYYGVTNTPPTRLLAADCTCVIVSHFLSNLRQVNTMERPLLRAHACAELAIRLVDRREYGRIASLRLRSPSQVDDVYGSDLPGNDPNKSDADGARGRQRGGSEGRHRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWT9</accession>
    <name>A0A401GWT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0905230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617556.1">
        <property type="nucleotide sequence ID" value="XM_027761755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWT9"/>
    <dbReference type="GeneID" id="38783560"/>
    <dbReference type="InParanoid" id="A0A401GWT9"/>
    <dbReference type="OrthoDB" id="5525680at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14074" checksum="507904EA37DCB15F" modified="2019-05-08" version="1">MPTEVAIRGSTVRDFQMLERNLLSHVRLAILISLLSSSLLLNARLPNPNRPPPVSAPPSNVAVAVAVIQVVAALTIIAAGIWEYQRSYDDLRQMRGFLLSTTIHFFAMVIIALIVFVTCIVYLVDSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYM4</accession>
    <name>A0A401GYM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1005140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618180.1">
        <property type="nucleotide sequence ID" value="XM_027762379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYM4"/>
    <dbReference type="GeneID" id="38784184"/>
    <dbReference type="InParanoid" id="A0A401GYM4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="740" mass="82058" checksum="0BAFEE909DD76ACB" modified="2019-05-08" version="1">MSLTYNPMAGDNVKIEPAQLERLGPGGSNASENAGVAAKDLNTKLEERDALLMEFRTITKLLSVIGPSCPEVLKKLGSPEIAGALDPAKQPGGMRGSFRHMTKADDDSDLRRLDAFASLLVREHENVAITFKRDTYPVVVVSQDQMASLPTTITIGHGRTMQVIAPTADADAQTGKDKRRAMPSSLLHGAWLIHLSQERTEQLFEEVKENPVKAVVDNALTQLFEEHASIITSFLSNYAMARDKKEKSNSSQMWTKYVYVRSAMKMYRRMFFTLSCPFWKALKNPAVEHFVEKKLDSFTFPTSKPKRGTDDDLAVYLKAILELGECPSESKLLAVCTSNTAKGATGTKALYTRETCLEFHMTLCHCVLLYRDAVVLSRDTWWRVLEWKGTCQNAGSQDCCALTKQDLQGLSERGVPVITSKAQALQNMEDAACVLRMAANTIHAFTYSSALSLHLSNIAEGLMKPFEEERNACQSRAHSSYNAEMKASREADAKARVEEKAKKPSVFDKSSDEELYHELSTSNWLDGSVVSDGHAEAKIPVPELSSDGKDGLPSAGDVVRDNGKACVEDGTFPPMAIYKEDEAQHNVNADRMTMASESDALDEGDDERESDLGAVMSSITPLVDRVDLKMAFERWFRLQASFPESIRILQGFASKSPWKGTGKPYEVNVLTAEHQGQEMLSMDDLIDKLYKDSPLKQYVSRYFERHPSITRRVGTTFSGTLHAEAFMAAILKSDSDCDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYW4</accession>
    <name>A0A401GYW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618268.1">
        <property type="nucleotide sequence ID" value="XM_027762467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYW4"/>
    <dbReference type="GeneID" id="38784272"/>
    <dbReference type="InParanoid" id="A0A401GYW4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14120" checksum="AE22EDA6D04927FA" modified="2019-05-08" version="1">MAGQQVDVNFFVPEEVGAGFEHQLFEPTLSREKWEGKVDQYVMGLTPEDMFLIGGTHDATDNSQLKPRSLKALKKRKAPADVDVNVAKQPPRRRKTSATNLQSVEGTANSERVSQEAQAGPSESQTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ08</accession>
    <name>A0A401GZ08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618302.1">
        <property type="nucleotide sequence ID" value="XM_027762501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ08"/>
    <dbReference type="GeneID" id="38784306"/>
    <dbReference type="InParanoid" id="A0A401GZ08"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7466" checksum="9C2FFB9FA8C161BC" modified="2019-05-08" version="1">MPPTSLPPSLSTSPRFPVSGPETGELSYITRRSFESEPSLSDALGGAFDSHSQYQFAARFNLSILELSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZQ6</accession>
    <name>A0A401GZQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1102960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618532.1">
        <property type="nucleotide sequence ID" value="XM_027762731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZQ6"/>
    <dbReference type="STRING" id="139825.A0A401GZQ6"/>
    <dbReference type="GeneID" id="38784536"/>
    <dbReference type="InParanoid" id="A0A401GZQ6"/>
    <dbReference type="OrthoDB" id="3250101at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF440">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="256"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="364" mass="41586" checksum="0A415CAB0E68662C" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGKDAKWLPKPTAEDAPDEEVLIFKEGGLSELITTETSPTSLGHSESIREIMADNTERGELPAVRNDTEPDDPLSEPPMDQLDDDDLVISYIAGEPVIGIFELIRKESPLTNEETETAVFTIRRGPAIGRMTHKLAQQAHKEASAVDKPKTVEELVPNYLHDLKSIFEKKAAERFPETRPWDHAIDLKPDFIPRNCKVYPLSLKEQGAMDDFLEENLQKGYIRLSKSLMASPFFFVGKKDGALRPCQDYRYLNEGMVKNAYPLRLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPTTFQMMMNALFKDMIDEGWIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0J5</accession>
    <name>A0A401H0J5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0014-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1201730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618860.1">
        <property type="nucleotide sequence ID" value="XM_027763059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0J5"/>
    <dbReference type="GeneID" id="38784864"/>
    <dbReference type="InParanoid" id="A0A401H0J5"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028:SF0">
        <property type="entry name" value="PROTEIN ALUMINUM SENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="323" mass="34855" checksum="58862CBD8160D9F1" modified="2019-05-08" version="1">MDTDPTQGTTHLNWGNVALAFSFILLDAGISLSFGLGVGSGLVTAAIRCVLQLSVVALILQKVFETNNPWAVAAIAFLLNLMGTIETVINKSKRRYQYMFPSVLFGMLSSTIPVSVIGIRYAMGVQPLWKPEQYIPVVGMLCGATISGIVVSVSYVLKELSDNRDKVEMYLAFGASRFEACKPIATEALRVALTPNINQMSVIGIIAIPGMMTGAILGGSSVEQAARLQMVIMFMISSCTALSSIVTTGLALAVVVDNQHRIRSDRIDSRKHFIWRATDRAMGKVIDAVKSAGNRAWSAVMKAFKKEDGILESDSGERETLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H159</accession>
    <name>A0A401H159_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619046.1">
        <property type="nucleotide sequence ID" value="XM_027763245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H159"/>
    <dbReference type="GeneID" id="38785050"/>
    <dbReference type="InParanoid" id="A0A401H159"/>
    <dbReference type="OrthoDB" id="2753739at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40623" checksum="2B1F379EF7BB0E5B" modified="2019-05-08" version="1">MGRFPAEVCDSVIDYSSWDPTSDKPDYGALRSCALTCKGWLPRSRAHIFHTVELNTQEKLGCFTRSIETSPALGDLVLKLTITHPDDDQPFHLMVAFPTKLAARLPKVKSLAIESPHAEPSVIRLSPEFFQSMSKFSTLTLLRLFHVEFHSFDDFGSLVCSLPNVIAIECWNVAWSECDANPFSETACPKITSLKVDDIEPTGLTQLLRAVGSSIRHLTFAADNEWLESFISDEGMSMAYLTRLKSLEIPIRLDRADFRMMKALLTQFTCDQLLGKLTFSFHYGCTDTPLESAKCALSGLQRTGIEDILTWPQFSELEEVVFRFSSVRDTDCLDRSWKMELISMLPRLQQRGIAQVELYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H164</accession>
    <name>A0A401H164_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619042.1">
        <property type="nucleotide sequence ID" value="XM_027763241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H164"/>
    <dbReference type="STRING" id="139825.A0A401H164"/>
    <dbReference type="GeneID" id="38785046"/>
    <dbReference type="InParanoid" id="A0A401H164"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27198" checksum="5D9D982C12C8AD17" modified="2019-05-08" version="1">MTYTEEDLNRDMTVITELGADKEPEDIYMKIQWEMARVHKLIVRHWIQIHKQFNTSAPIDDAENYFGYAGHWVHHHHSFEEEISFPRWAPNLSTTTEQSQHKELMTELYRFQEYIAAVTAKSEPWSATKAEAHAQALLPPLMSHLVGELHTLDPDALRRSGLTAEALTDISDAVIKATQTSLDMHKDIPALLLHNDGDLDWPTTTWQRTAEFTMPPELYKPYAECVFLRYICYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H174</accession>
    <name>A0A401H174_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase gliC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1203600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619043.1">
        <property type="nucleotide sequence ID" value="XM_027763242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H174"/>
    <dbReference type="STRING" id="139825.A0A401H174"/>
    <dbReference type="GeneID" id="38785047"/>
    <dbReference type="InParanoid" id="A0A401H174"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303:SF31">
        <property type="entry name" value="CYTOCHROME P450 307A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24303">
        <property type="entry name" value="HEME-BINDING MONOOXYGENASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="511" mass="57929" checksum="56053C9F698222AB" modified="2019-05-08" version="1">MIEGDTSLKNLVSVSNVVILTVVVAFSLLLKGVSLHTTLRNLVIGPHDRVAGSKGVRRIPGPAYKWPFGQLEDKFLRGRKKGQEWQALYGDIYRIWSGDQLEVVLTRWQDAAVFYRDAHQHIKPRDSDGGWLFRSILGFGLGLVSEGQWRRLRGHFDPHFSFASISTFVPDVICDGDEYVKQLLPNPAQISRDFHVGNDFKMFGFFLVAKLLFGELDVKQKKALEELIDMHSDIFKLIFNDVTSMIPAARHLPFLRTNRALKKFHHHWLQFNHDAYAKVKGDTNYPITHLWQAMENGSMSEKELLNTVDESLFANVDVSASAVAWSILLTCTLSAHQARLRTEIAENAHDVDGYVRRTDTYLHRTLLETLRVRPVASLIAPESATVDKVLDDGHVIPSGVKVITDVVAVNVRDPFWGADAELFLPDRFETLAGEDVRRHLFTFGFGPRQCLGKYLADKMIKTLLVYMFGRFEGETLPGGKDADDEWKVKVDTFVQLPDAYVRLTRLNKPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1S9</accession>
    <name>A0A401H1S9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1301890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619287.1">
        <property type="nucleotide sequence ID" value="XM_027763486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1S9"/>
    <dbReference type="FunCoup" id="A0A401H1S9">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1S9"/>
    <dbReference type="GeneID" id="38785291"/>
    <dbReference type="InParanoid" id="A0A401H1S9"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="344"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="422" mass="44692" checksum="33DEFD5D244126B1" modified="2019-05-08" version="1">MASERMEEDHLEEGADGEEEEFIDPNDVFVEVADDDDLPMDEDDAEGEGAPQVDESVVYEDNSMQHFPNHHASVFAISTHPSAPLAASGGEDDLGYLWDYTTGQELVKLTGHTDSVTSTAFSADGEMISTGGMDGKVRVWRHVGKENWRTWEFLTELQGPDEVMWLRWHPKGSILLAGSNDTTVWLWQLPSGNTMQVFAGHTAPVQCGDFTPDGKRIITADAEGTLIFWDPRNPAPLFKLSPTNARFDLDGITSVAVNPASTLAVVGGASGGVRVVSLSKGEVVGALGGHKEGESIEAVEFVDLTGALAGVVTAPPAAGGVVATGGTDGKVCIWDLGTMRLRATLEHEDAVTSLLRLPPPKGHLLVSGSADKTLRTWDARTGTLLREHKGHHGPVLGAALGLGGGVVVSAGDDGVCLVFPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2D0</accession>
    <name>A0A401H2D0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1303680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619465.1">
        <property type="nucleotide sequence ID" value="XM_027763664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2D0"/>
    <dbReference type="STRING" id="139825.A0A401H2D0"/>
    <dbReference type="GeneID" id="38785469"/>
    <dbReference type="InParanoid" id="A0A401H2D0"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="323"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="637" mass="69078" checksum="B76B7F515109378E" modified="2019-05-08" version="1">MPGSESKFPVDLHKLKKLQLDPSQPKLTAEQKSALEHNVQLMRDAIVLFTATGAARGVSGHTGGAYDTVPEVNLLLSLFNYSDKYVPILFDEAGHRVATQYLLAAIEGAIPAEHLLHYREANSKLPGHPELGLTPGIKFSSGRLGHMWPMVNGIALANRSKTVFLLGSDGSQQEGNDAEAARLAVAQSLNVKLIIDDNDVTIAGHPSQYLKGYDVSKTLAGHGLKVVTVQGENLDALWAGLCEVITHDGPAAVVCKRLMAPGVPDIEGSIHGHDAIPVKSAVNYLTSRGYPESMATDILYNIKPASVPSLFIGSTKEVGANRVVFGEAVNSVLDKLSKEEAAAKVMVIDSDLEGSTGLKAIHQKHPEVFVSSGIMERGNFSAAAGFGFDANKFGVFSTFSAFLEMVVSEITMARLNSCNVLCHFSHSGVDEMADNTCHFGVNSLFADNGLADTHSWLYFPADPAQMIAIVQRVFFERGLRFVFSTRAKVPYILKEDGSRFFDGNYKFEPGKDEVIVEGKAGYVVSFGDTLYRSWDAVLRCRQEGLDVGLVNKPTLNIVDEKTIRKIGSSPFVLVVESLSQKTGLGSKFGTWLLERRLTPRYGYIGTTKEGCGGLSEQIPFQGLDPQSIILKIRQLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2G5</accession>
    <name>A0A401H2G5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619538.1">
        <property type="nucleotide sequence ID" value="XM_027763737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2G5"/>
    <dbReference type="GeneID" id="38785542"/>
    <dbReference type="InParanoid" id="A0A401H2G5"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="289" mass="33120" checksum="5584E0045CEC3F64" modified="2019-05-08" version="1">MAQNIVSELCEYLSRDAAEDGCEIFEQVDTVVVSDDIQMNQQIYCKDSKGIMTQMGFIRSLGPGSQRPHRRLKHLFFQDDMNWSTEDEDAYCVSRFKPPWHRTTDFNGISDLSFSRERPTIDKIIGDILEPYWQSCCCNPARTKPVNIIILTNNAAKDPTPLKRVIFNSISDIWLYKTKPYQVSLYFFQVGNPDSLKDQDDQTMAFLKDLDDNLRDDILAWPLRPKMEIERLDEEYTGLMNAISETSKEKGLGMFDIANSTTLENLESGTLTAQGITKVVIEGLRKLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2I8</accession>
    <name>A0A401H2I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619554.1">
        <property type="nucleotide sequence ID" value="XM_027763753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2I8"/>
    <dbReference type="GeneID" id="38785558"/>
    <dbReference type="InParanoid" id="A0A401H2I8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="12059" checksum="FA2C164CFCA5E8E4" modified="2019-05-08" version="1">MIHAFDWAAYIRSPFMQGPRHHEFLVWYRQRGPGKVRMCLELFYDQSDKSLDPNRKGSVKSFTRYLCGYNVQAGDAVLERHDILWIASRLPFPRLPDNSDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Q9</accession>
    <name>A0A401H2Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor ISY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1401060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619614.1">
        <property type="nucleotide sequence ID" value="XM_027763813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Q9"/>
    <dbReference type="FunCoup" id="A0A401H2Q9">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2Q9"/>
    <dbReference type="GeneID" id="38785618"/>
    <dbReference type="InParanoid" id="A0A401H2Q9"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="333" mass="38015" checksum="DE7BC579C00A043F" modified="2019-05-08" version="1">MARNEEKAQSMLYRFREAQAAELGLGTRSDRRPKMASACKSLRDCERWRGEILREISRKVSKIQDAGLTDYEVRDLNDEINRLMREKRHWENQIVALGGANYRRNVAMLDDDGKEVPGTKGYKYFGRAKELPGVKELFQSKKSEEDEENQTQHYYKKFTNQGPAYFGDVDESDGKLMEYELRAEESEWEDAYSHLRSVLELPSNEPVPKIPRPSHAQTKVSTSEASDALSPPPVDTKRKAPDGDVEMSSGGGSDEQFKRARKETRQQQRNGDVPSTAENTALSYARATATYIPFLTPENLLPPKMPTREEMEAHLLALRKQALVEEYFGNEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3C2</accession>
    <name>A0A401H3C2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1402580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619763.1">
        <property type="nucleotide sequence ID" value="XM_027763962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3C2"/>
    <dbReference type="STRING" id="139825.A0A401H3C2"/>
    <dbReference type="GeneID" id="38785767"/>
    <dbReference type="InParanoid" id="A0A401H3C2"/>
    <dbReference type="OrthoDB" id="2789888at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF33">
        <property type="entry name" value="SERINE_THREONINE KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="422"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE88850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="711" mass="79914" checksum="AA1FE3553CD3D386" modified="2019-05-08" version="1">MSQFTINIAYDILCSVVDHPTMIGVPVPTGMQWVNLATEIARHPLVGRSGAPLDLYKLRTPADVKDLEQGLQMGGVEGIADKVRSFDQVPHDMTQFPLDKVHVIVVVGQQRKTAEGFSWDILLQTELAKLLLVVIEIPNKWSRNDVTSNGGVFLDSSCSVLQDIVVKLKAQRTYQANYDSFDFQNASRLPLFSQSFISVSESHGTVKGDDEFETFYHVLRRFSGDAPLVRSDPSSSLKASSFTVYFIHCPFFSGSIRSDPLQYKEQLSWQFPMFVTRRDSLGHVRKYHPNSDFSVVLREFRCPVVLSEVVSQKDENDRHRMLMEAIVVARVGKYLLKPTSRKQFFVVAIYLTTSLQVERYIVSEDSSPQINIQQETFDLCNPSRAAEFLREMYNLKPLLEELAAELDEKKRVDLAKIETDSSKMLSLNSRGPWTKPHSRLESVAEHDESMNISDDTGVFNTRSVRSVLDKANCEIDSVGYGHPHVALVVRKDDGASAGFLKFVKDGNPEVEIMQYLSRIDSPANHTIRPIRVWPIEGGTIVSMPVGGGWISYLDDLDARLWGASQQLFEAVGFMHDHGVAHMDLKPGNIVIPPIYGNLSIIDFSIAVRVKGPGEKLMGYAGTRGYTAPEVGRVAYRPIRADLWSCGKVIMELCENAKPSFARTWLCVVSKRLMDDDPDKRPMMAEILQAMSRVGRERDELERQISGVVETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3K7</accession>
    <name>A0A401H3K7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619882.1">
        <property type="nucleotide sequence ID" value="XM_027764081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3K7"/>
    <dbReference type="GeneID" id="38785886"/>
    <dbReference type="InParanoid" id="A0A401H3K7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="140" mass="15662" checksum="F5117C66BF16E2D0" modified="2019-05-08" version="1">MTGNNTLNSSWNPLESPQACHHWSLFPDDADLDAATEGEAASEDEPDDDERDLQEQYIEHVEPELPEDELSEGGGAERQEEGCEDERGDADVLLQDNGATLKCRSVLKILECIREENMTLARFLEAFSWVKAKKHGLCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3S8</accession>
    <name>A0A401H3S8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619913.1">
        <property type="nucleotide sequence ID" value="XM_027764112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3S8"/>
    <dbReference type="STRING" id="139825.A0A401H3S8"/>
    <dbReference type="GeneID" id="38785917"/>
    <dbReference type="InParanoid" id="A0A401H3S8"/>
    <dbReference type="OrthoDB" id="3070852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12798" checksum="A1F9359203123EAC" modified="2019-05-08" version="1">MSNDSASEPPSSVVSFGSYADLHTSASSSTSCSSVDFGYNPFTSYGLLLGSGNQVWHPPMLPPDQSPHFIHPPMLPPDQSPCFIHPPMLLPDESSSMFLHPPMLHQDDTDTIRAQLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H400</accession>
    <name>A0A401H400_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1501480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620055.1">
        <property type="nucleotide sequence ID" value="XM_027764254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H400"/>
    <dbReference type="STRING" id="139825.A0A401H400"/>
    <dbReference type="GeneID" id="38786059"/>
    <dbReference type="InParanoid" id="A0A401H400"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="219" mass="25269" checksum="0A36519D370CE759" modified="2019-05-08" version="1">MMPNLSGLKDIMDNPEGLQRLLDMVQHDAMDAEARGETFQERMMRERAEWTETDDRVKEQGNQAFRAGDFRRAYLCYTGVIDVSCHWHDAAYWLNRAAVCLKLNAYACAEDDANMAWQRKPSAKALYRRGQARRFLGRLAEAERDLSDALRMESSNKALADELALIQFLRTKSDEELQEWLAENKGVDRPLSGVSDEDLRELAAKMYKECQPPGWQMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H479</accession>
    <name>A0A401H479_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_1502540</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620159.1">
        <property type="nucleotide sequence ID" value="XM_027764358.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401H479">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H479"/>
    <dbReference type="GeneID" id="38786163"/>
    <dbReference type="InParanoid" id="A0A401H479"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000193">
        <property type="entry name" value="Protein transport protein SEC31, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="SRA1/Sec31" evidence="17">
        <location>
            <begin position="1365"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="534"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1042"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1042"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1143"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1157"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1209"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1264"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1282"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1328"/>
            <end position="1349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE89246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1467" mass="156396" checksum="08A7B085D0B9D738" modified="2019-05-08" version="1">MKLKEIHRTSTFAWSPSPSLPLLATGTFADALDESFSNNGRLEIWEPDFLDKNEFDLGAEGHPGPKASVKTTSRFNRLAWGYADGSRPSGVIVAGMENGELDIWDPSQIVADSKPSESLLLRNKTHTGTVRALDFNPMRTNIFSSGAINGEIYIWDLKDPSKPYTPGTRSTKLDEITSLAWNHHVDYILAASSNTGYTVVWDLRGKREVAALAYGGGAGTLSGGIQGFAVPGMAAGGRRGMSDVAWHPDNATRLVTSSEDDTSPIVMVWDLRNTRAPEKILTGHEKGVLSLSWCTQDPDLLLSCGKDNRALCWNPQTSEMIGELPSADGWAFQVQWCPRNPDLFAAAFFDGTIGIHSIQSTNEAAELPPATPQPDGSDIFGAPGFPRSNHATLSLKHPPKWLRRPASNSFGYGGKLITVSNLPSAQGRNQSCVVHIRTVVTEANIVERAIKLQAAIEGNNLSAFAEDKSEEDGQKPEDSGSASWKALLSLFKANSRDELIILLGFSKAEIATRVAEAIVNLKAVPDSALSFTEQDVTDSDLKRHEPVVSFAEPERETYSDHGDPEADETLDASTYGAETTPSEVSASAASDTTNATPQADGESTTTAPSLFGDDNLGGNQNDVAADFFGTIGAGNDDQQMQVPHHNYALDSSVAATIGSGPSSVASEALKSNTFRIYPSDESETDRLVTRALVLGDFESAVSLCLSSGRYADAILLAVKGGPELLQRTQKAYFERRTTALPYLRLFQSIVTNDLADIVQNADLQEWQEIFVVLCTFATHEEFSGLAEQLGRRLEFQSSLAKVSGSSDGREKAAEFRRHATLTYLAAGRLERLVNIWLEELAEEEKLLSTDEGQLDGSRYTAHALALETFIEKVTVFRSAIKYDDTDLSLKTESEETATKAYKLSGLYDRYFEYAGLLAAQGLLQEAVAFLRLIPEGYDGSSGAMIDLAAGRERLLKAAGVSVASTRTVSISATATAVAAKVASTSSVYSYGQYSAPVQQLVAPQVPAATSVYEPYNSSGFTASSQVTNPYAATAAVASQQSYQRQPYQQQPYQSTAPMSYPSNQYARPPVQAQHVAPPHVLPPPPRAGSAAPSVQPVPPSKRENGGWNDVPHHVGQRRTPANSVSGRPAAITSPFPNMPSPGTMPTSPYSTSGQPPATLPPPPRPGSVQAHPPPPLQGQHLPPPTGQYPPHTRAPSGPPGPTGPRIQHLPPPPPPGRIMLSPPPPGPGLSRPPPPAAGPGPYSPVGSSPGQSPPPPPHGHGHLSHPSGSGAAGPSGPYAHATPPPLGPPPPGAGFTQRPPPQQATFAPTSQGAARVGPAVGPPPQGPPRGSTPGSGPRVRLSAAARANAGPPPAKYPPGDRSHIPEEMRPVFTVISGQLERMKQTMPAQQKRLVDDLERRVNALFDALNCETLSKPVCEQLIVLTSAMASHDRDAAMALHMDLLTTGSLTDDIALWMSGIKQLIMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4G2</accession>
    <name>A0A401H4G2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620217.1">
        <property type="nucleotide sequence ID" value="XM_027764416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4G2"/>
    <dbReference type="GeneID" id="38786221"/>
    <dbReference type="InParanoid" id="A0A401H4G2"/>
    <dbReference type="OrthoDB" id="2756860at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22866" checksum="32BD5FD2283BE213" modified="2019-05-08" version="1">MVLTHDFIVWDRHGRDTFLLDSEDTLQIAIKDEEGIMAINLARLTGALSMLPMAFYLCSNLTPSELIRGVTRQDGTVERLSADDLAACMEGRVRLTTANTVGNASIYLQNSPACSRRPLCADSFKRFLRIGLIFSPTDSISHHSLHQRDGSLNNICENDKVCWDCITFLMTSDYERRRKLWEILPSIFGLEDWKHLRAAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5K1</accession>
    <name>A0A401H5K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1603230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620572.1">
        <property type="nucleotide sequence ID" value="XM_027764771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5K1"/>
    <dbReference type="STRING" id="139825.A0A401H5K1"/>
    <dbReference type="GeneID" id="38786576"/>
    <dbReference type="InParanoid" id="A0A401H5K1"/>
    <dbReference type="OrthoDB" id="3238562at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="35499" checksum="1C2AD62421EF901F" modified="2019-05-08" version="1">MPLQYRSTSTLVEEHTDAINCVALSPDGLFVASGSTDKRIVVWSLSSGQAIHRLVTHSAVLSLLWRSSPSRIICGTADGTLITAAFNEENIYVSGFSAHSKPIECLSLSKGTTASRHLATAAHNVVNIWSSVENDTYWDYGDTLDAPPSTPYSASHSVIITSVQWMNDPSADCLVTAYLHHGIICSRRGTGSIEVLWSIHLPLCGACNISPANDTLAVCNITSGFDVYAIPSGLRRLVLEVPSEPPGMALPIVYIHKGTMLLGGASNGKVRLWDARSGDIVQTLRYHGKFDPLLIQCVAENPDTFLLATGSSDPGVPNSIQVWELRDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6C1</accession>
    <name>A0A401H6C1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1800200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE89998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620911.1">
        <property type="nucleotide sequence ID" value="XM_027765110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6C1"/>
    <dbReference type="GeneID" id="38786915"/>
    <dbReference type="InParanoid" id="A0A401H6C1"/>
    <dbReference type="OrthoDB" id="3003360at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="236" mass="26603" checksum="750FECDDC6857FFC" modified="2019-05-08" version="1">MSAPASAASPLYVDQLTPPVNTAFFIRKEFVLPLKDNIAWQVTAYVFITGANPTEPRFEEKGGVVYVVLVHGGRGTYSSLFPFEQMQFKVKLEGMTPQMQLPPTGSGEPEYNAHGEKMPDTKYTIQFERSMAMFLNGGNEPYMFDAKFEQVFVRHDLGTQTGDVMADGTGTAFSISGFRFKNDTETLEIYGLSVFKRTKPLRELKLLFEYEVFPNAVFLKPPQWESETYTVALPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6H0</accession>
    <name>A0A401H6H0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620950.1">
        <property type="nucleotide sequence ID" value="XM_027765149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6H0"/>
    <dbReference type="GeneID" id="38786954"/>
    <dbReference type="InParanoid" id="A0A401H6H0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14755" checksum="14FE66B3FE9B5496" modified="2019-05-08" version="1">MHQGRHHRQDRTSRPVAARSVHAPCAASITRHRLPDNIQRAIKRATRRELTRPRSGATRDMGPSSGVLRASAFPLLPQIWGARHRRDPEARPTSPSPAQAVISSSSCRLSTLRTRLFAGQMPAAIFIESPRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6M1</accession>
    <name>A0A401H6M1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1800630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620954.1">
        <property type="nucleotide sequence ID" value="XM_027765153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6M1"/>
    <dbReference type="GeneID" id="38786958"/>
    <dbReference type="InParanoid" id="A0A401H6M1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="66" mass="7140" checksum="0BCE07A04A177587" modified="2019-05-08" version="1">MPPLSTSNTLVLLVLVVVIFLSPVSLIIFAVLPRRTKQRALRPHSPPGSPTLAPAGRPPPHSHYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6W2</accession>
    <name>A0A401H6W2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1900250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621089.1">
        <property type="nucleotide sequence ID" value="XM_027765288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6W2"/>
    <dbReference type="GeneID" id="38787093"/>
    <dbReference type="InParanoid" id="A0A401H6W2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="16056" checksum="1A821FC99B8FF3C8" modified="2019-05-08" version="1">MPWLKRLNPMINWDTGDFWFGKDAKWPLKPTIEDVPDEEISIFKKDDFLELITTETSPTSFGHSESIREIMVNDTERGKLPAVRNDTEPDDPLLESSMDQLDDDNLVISYIAGEPVIGIFEPIRKESPLTNKETGTAVFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4P6</accession>
    <name>A0A401G4P6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608069.1">
        <property type="nucleotide sequence ID" value="XM_027752268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4P6"/>
    <dbReference type="GeneID" id="38774073"/>
    <dbReference type="InParanoid" id="A0A401G4P6"/>
    <dbReference type="OrthoDB" id="2919059at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1122" mass="123267" checksum="16001765AB13ACA0" modified="2019-05-08" version="1">MDPLKQYLHILKEDIAWHKFVDDGQKWPPNVRELCGGLLTDSRRVPAWVTTGPYPAVDPRTEPLLEELQNTFKLHAGSLEDAVFDQQLRGMFGTLLSDCARLRNVMSSDSLCGSANPKESFLIVMISNVMSSVTADFSIDENVLVALPRYRGGGLNVPTRFMSNSIQVPLLMSVFAEIPDDNSNADGSDAMANDPDTDEADSDAGSHNPDMELGEDEPREPSEPPRPVSVASPMSMSTFLSRCAKPVLIEESDSDSESLYDPPSPAELNAHVLVYPPSRALPKRVPLPFMCVAEEDDLPLVMMAILYQRHVWKIHEPVVGVGFSKYDTSISFYIGWLDEDADKEDSLPRVHLGSLGRDGSLDLASLDGAFALCHAALALQGLVAKTCGVSEATVTVVAEEIRDGSVSMWRLDTQEDVNSADSSEGQRDWIEAWAEGLAYKYPATTMTDSKKTATADPKKTAQEARKKGSTDSLSVPSMGSSRSTDSTPSSLPMIAIPEEEEFIQEGKSQGSKKSAYKPMSCSSFAAAAAKVGNSLLLHGYLFDRHVILSALCNNSVIFSLYEIHAGDAWPSHWKTLSDIPLVDRSLEPFRQELFAQAQKHHELSAVVPRDVPAEVLPLLEGSLSLILAVAKRAQRKARSVIPPSESVWRHDFDSLIFDFFTNALNGTISMYSRNSRSSDAPKLQLPDGDRVIPSTERMIYLPKAVGMDQRSARNLYSYIQRSGPDSDETDNEMLKQRIGPNEDLLGEAGDLERKAYAQNIHHATDWLERRKMNGYALERLKEDPYRAICDALGTVSIDLPVRRESLAAVQLVATGSPKAPYIVRMHESKESLDMPDGTSSGVAPTIPLQQRLYSSAPALETVPEVDDPDQALPSNPGIPHSTGKLPPPANPPNTDSLPTRDYAIAASSVCDTDRLYENAEARAYLDENFDVMSKRLEVLTAGQRKNAKVKNPVSVLELPAFMMEYKKQDTDIGKGENQHRLACASAVTFLDVLGLTKKPVFSGLTNGPRVALAAAWSNSGFIEIFERQTRTMDISTALGAFQFASVLARLAIVYSKDLVDAFNEVSKSLLIKRLNDRDFEKPDSKLQWKQPVPPKSEREESGDATTQPIQTSEWSSSVTEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5W5</accession>
    <name>A0A401G5W5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0104210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608457.1">
        <property type="nucleotide sequence ID" value="XM_027752656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5W5"/>
    <dbReference type="FunCoup" id="A0A401G5W5">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5W5"/>
    <dbReference type="GeneID" id="38774461"/>
    <dbReference type="InParanoid" id="A0A401G5W5"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="86" mass="9606" checksum="3BF852468F9CFD0F" modified="2019-05-08" version="1">MSSELRYTANTQLEHLHARYTGTGHADLTKYEWLTHQHRDTLASIVGHPTLASYLAIADGEAVGRVKFEMTERMLQPCGPPPAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G606</accession>
    <name>A0A401G606_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0104570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608490.1">
        <property type="nucleotide sequence ID" value="XM_027752689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G606"/>
    <dbReference type="STRING" id="139825.A0A401G606"/>
    <dbReference type="GeneID" id="38774494"/>
    <dbReference type="InParanoid" id="A0A401G606"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="134"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55683" checksum="435F58A123060809" modified="2019-05-08" version="1">MNGASTARHGRPAPTGITPPAPAAAPPAPPNHAHPPPVARPSNGAAVNGTHPPIQKGKKKAAEQPVDPSQMYETLKNRIAALEEEEVHEEEEERRFTEEAQNSVSGMGDNAVHGKYIELFAEFKRLERDHAKEKQKLVKDKDAAKSQLSKANQTKTKMENLARELQKDNKRLREDSKRLATCVEEAQEEITQMKNDMAKRAERAKVQDTKYREMPDIVVRVVCKYRAELYFKISRKTKLSRLFNAWTERMESGIGNKGDGKTFLSGGGLGSPQVNGTAKSDAASLSSSSTPPASSMQFVFTHSSRSLEADQTPEEAGIEDGDVILAVEIMDLTEGPGTEELDEGGEPRREKLKKEWAESPQEARKTMEGIFDGIVRERMKDVLRQYELRERHFECVVRSKELEVLLSRARAAEQRQLAEGEKTRADKLEEDIKQLRKDLDDATDQQTILINKLIACCQEENVDDRTQRIFGSLREELENRANHMANNAPPEGSPEVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6B3</accession>
    <name>A0A401G6B3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0105870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608618.1">
        <property type="nucleotide sequence ID" value="XM_027752817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6B3"/>
    <dbReference type="GeneID" id="38774622"/>
    <dbReference type="InParanoid" id="A0A401G6B3"/>
    <dbReference type="OrthoDB" id="2919381at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="40167" checksum="E442FEEBE37EF2C0" modified="2019-05-08" version="1">MPLPPRHMPPGPPPRSGAPGPPTSPTSGPPAGYVPQPPVGPAPAPVKSRAQQAYEHLDNDESESEPSTTDGDNEPDDAEVQRLNRQHQRNHGPMNLPRQGASRSDDKGNTVPRPSDTDNDVSLAPHNWPDTFPLPVNTQPWKVTEWYNFVPWYVRDSQRIIDVAHGGDDGAHTWVTDLIRQMQQDGCLTVSHGMMNLLMSWRRHGSSGVIYPPMVPPPCRMTNLTSSSTFDEWVAWYVQNPSQVYWAIRHLNNNHSEAPLHQDLEVMWLARCMAPIIPLGVPAMARNVFIEHTAELFSILGLYAWIVQVGRYPMANNNEPAPFPRSSAQNSSIYDVARWYAARGFHPMRIGFLEEFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6M2</accession>
    <name>A0A401G6M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0106900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608721.1">
        <property type="nucleotide sequence ID" value="XM_027752920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6M2"/>
    <dbReference type="STRING" id="139825.A0A401G6M2"/>
    <dbReference type="GeneID" id="38774725"/>
    <dbReference type="InParanoid" id="A0A401G6M2"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="263"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="592" mass="65195" checksum="A8880BAFD84BB9A6" modified="2019-05-08" version="1">MQQKVEQPRPLPVLRWFTGTHARRSSKSHPSSPGHSRTASPPRYPSSAPPSPSTPSSATSALADALHDDPHLVQAHSHLEAQQIHMPARPEAARLPPNLRPYRPPSYLSDLARSTLPTAGLSSTPSVSFLSSTYTDPFDNPFPEESEYNPDLDVFYSPTPVPLVIPHSPARAHLSSSPPTLFRGRSASVDTLRSIQERGRGIHTTPPQALRFPTLPPSIRNWFNPEGSDNKENLHPLLSEQDQAESPEAERDHIRQKYKSPQNPLVFCHGLLGFDTVNLGPSIAPLQVDHWRGIKDVLRSNGVEVLTTRVPATSSPIDRAKVLLATISEAYPGRSVHLVGHSMGGLDCRYLTTHLTDRPFKVLSVTTISTPHRGSSFADYFLSTIGPSRLPSVLSLLDLLPNGGGDGQAFEFLTVENMRRFNERTPDVPGVKYFSWGATYDPGLIDTWKWPHSVIMEKEGPNDGLVSLKSAKWGTYLGTLEDVNHLDLIGWVNTARYKWAEIMGREVKFKPATFYLGIADHLARVVEGQDAPEVAQSSADGEAHEVDTAKREQTRKEGERAEMADSLAKGSPSVERGRVGERAQTDERRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8B3</accession>
    <name>A0A401G8B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0112740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609302.1">
        <property type="nucleotide sequence ID" value="XM_027753501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8B3"/>
    <dbReference type="STRING" id="139825.A0A401G8B3"/>
    <dbReference type="GeneID" id="38775306"/>
    <dbReference type="InParanoid" id="A0A401G8B3"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="49"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="27280" checksum="E651C12435E2F0B5" modified="2019-05-08" version="1">MPSVASVWAEPPTRTPLIENLVSGVDRYNPNNVGILEDYLYHQIRSEEYDCLANLAILKLYQFNPDLYNPDVVINILIKALTSSPFPDFNLCISLLDERSVNANPDEPDPLPSLLPILTTLYNLLQQCRFPAFWSLYRSDQVESLRDNYTVECVGFEDSIREVAIRAVKAAFTRIGRERLGTYLDLTGENLNAYIAKLGWTVDSATGVITVPPNPDNQIVSTVVQENIKLPQLIKVIAHTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8V3</accession>
    <name>A0A401G8V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0114950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609519.1">
        <property type="nucleotide sequence ID" value="XM_027753718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8V3"/>
    <dbReference type="STRING" id="139825.A0A401G8V3"/>
    <dbReference type="GeneID" id="38775523"/>
    <dbReference type="InParanoid" id="A0A401G8V3"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019250201" evidence="6">
        <location>
            <begin position="20"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="56"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="448"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="479"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="600" mass="63847" checksum="C66684B137437AF8" modified="2019-05-08" version="1">MFAGLVFLSLSSLLATGHALKFPVQRRAASHSDTVVVTNPANANNVGFSDAWQAYGLYTITVYVQGQPFQVQLDTGSSDLWIDTSNVTIDGFIDTGYNSTDIYADSTESSGPIVMANVSVGEFLVEGQAMINAIDSNATAAGADVGLLGIGPPLASQIFWQLLNSSYSGMPFLNNVFNYHPDEQAFITLLLTRSNIGITEGGVFSISELVVDYASILDTPQLPVHSDTDFLTFMDGIYVNGEFLTGHSMGVNGTSANAIPNENQTLVVLDSGTTLIPAPQYYVDAIYGNIPGANFSSTMNTYEVPCSTKLNISMLFGDILVPIDPIDATMVNVTDDGSVQCFGTFAYMFDGTPLDFLLGDTFLRNVYSLFYYGNWTAASVGTAPYMQVLPLTDPDAAWANFDALNLQRIGQLEWQQMQANANITSSYAEAASMSVTYSLAPPSAVRTSISSVPPSSVPSTSVFPSSATPSSSPSPPFSNSPSSPSSNSPSSNSANSSPATPSSTPGSAVRPNADLASSSSGDSSSVNLSGLTRNSYIIMGLIGGVLVLLIGVLIKLVKDSRNQQYRAVPNIIRPPMHFNDKPYEPESEEFTTPYDDPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9H9</accession>
    <name>A0A401G9H9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0116860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609706.1">
        <property type="nucleotide sequence ID" value="XM_027753905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9H9"/>
    <dbReference type="FunCoup" id="A0A401G9H9">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9H9"/>
    <dbReference type="GeneID" id="38775710"/>
    <dbReference type="InParanoid" id="A0A401G9H9"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="93"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="348"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="879"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1246" mass="135670" checksum="A32971B6B1C5024E" modified="2019-05-08" version="1">MAPSIFAGVFYYTSISIPSCLRDQLKQILDDEGASDVPLDDPLLTHFITLTPPSDDVLERIPNKDKVQQVIPTWAERSFVLGKQQAAEHYSPNPANLFSGITATATDLSPADLELLSAGITSLGGQWRTALTRDVTHLFALSPGSAKYETAMHYREQTAMCVLVPHWFDDTVRLGIRGLPTDEYEWPHPRVFKPETSTDGAAPDVPYRLSSEKKRFYETALASSFDRRLSRAPPRNIWNGLRILLSDSLELSASQRDAHEEDIRREGGIIIPLSLIGSGTLLEVAQEEARQVQQADVLITRYRVGVAYVKAFKAKKTIGSMTWLWHVRSTGALSRPTDKLLHYPIPKGAPEGFAEHSITITNYTGKDREYLKKLVSTMGGKFTASMSNTNTIVIAAYVGGTKTAKAVSWSIPLVNHTWLEDAFVHWRAPTPALEKYLCFPPGVDFGGLLSERGVGPLEYTQQELAAMARAGIPGTEAEKAAAKEKALALTEGKSFGKNGTEDGVEGSRDRHIRATPSPARTGNSAREVEDVVMGEVVDASIMDVDADILPPRDKDAGAMDVDEGHGAKPSTKKGDGKKKVVTVDEDEAEDENVPVPSVPLPRPPKKKLVRRYSRQSSSDVAPSVPEPEELEKQQLQPITSPSRSVLRQYKSKSRLEAEEAQDKMKIGPPKRKPRQDKQKANRADKEREDDRPAPKVRPSKRKTIIPMDSSEDEDMEPPKAESSARRKPTQKADAPPKPIKGFKLPIQGDLDSSDSSSSAAPAHPKRTGPASRSATVPESVAPSRSSTSPTKLRQQVSVLVPTAASVYSSPKSKKSVQGTPAKSALRRTDSVRAAAPEASVQSPTKRGRPSGSAKRAASSVSFQPPTEDSTTITTAPMPAALTRTPSRRSAATRATRKLHEEIMPDVMNFQKEMKNGTVRSVWEAEERDKSKSASVGALDEDARKGRGKKRVSGAAEEHGAEEQEEQPMKKRLRTSVGTASAKKGKAGVAGGARQSSGKRKRDSSSSSEEDSSEAGIGKPRRKPESGAKRVSLGAANTSRTNPKNARIMTTQLSVSDDVKQVLTRMGVKMTTKPTECTHLVTNNVVRTEKFLCALPVVQHILSEKWLLASAATKQLLPESDYALVDPEAEKKFGFKLAEALRRAHAGKLFAGMTFYATPRIGVDHKLLKNVVTANGGQLSTQTPTARILSGQAHRYVISSPTDVSIWRPLAEQGHAVYTQELILTGALRQEIDWDSPTNRVAGSVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9T3</accession>
    <name>A0A401G9T3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0201430</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609859.1">
        <property type="nucleotide sequence ID" value="XM_027754058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9T3"/>
    <dbReference type="STRING" id="139825.A0A401G9T3"/>
    <dbReference type="GeneID" id="38775863"/>
    <dbReference type="InParanoid" id="A0A401G9T3"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="442"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE78946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1052" mass="113696" checksum="5237E06ADCFE636C" modified="2019-05-08" version="1">MRTAYFSDDVLSSLESSLSHKNDGQLPLPGLSRRLAMLWHRRSSWAFPAFLSLFIVFFTWPFTLRTAASTRAEYADLAAASPTLKSDNLTDVVQWDNYSLFVYDQRIFLHSGEFHTFRLPVPDLWLDIFQKMVAAGLNAVSIYIHWGLTNPAPGVLDFNDWRALQPFFDAAKLAGLWIVLRPGPYINAETTAGGIPLWVTSLVAGQLRTNASDYEAAWQPYIAGIAENVIPNQVSSGGPILAVQVDNEYYQDAVTGEYFAELEAAYRSAGVLIPLTYNDPGEGRNFVNGTGAVNIYGLDSYPQGFDCSHPEQWASVVTNYHQYHEEVDPGEPWYMPEFQGGAFDPWGGPGYNNCEILTGADFMDVFYKQNWASNVKLISYYMIYGGTSWGGLPEPSVYSSYDYGASIRESRLLSDKYDEIKRQGIFLRSSPSFRKTDWVGDTSTTIPGVTVNGSGAYVTLLYNYDTGTGFYIARQADSTSTTNINFTLTVPTSAGTLTIPSTSGAIALDGRQSKVIVTDYAFGAQSSVLYSTASIFYAGTIGARDVLFLYGDANQSHEVALVLNGSSAQASDVSYSNAGGAGGITTVTFLPGITGLVTVWDSATQLILYADPITTATFWAPAIPTAGASTDFPNYFQFGTNETVLIGGPYLVRNASIADGELALRGDLNASVPLTVVAPPEVTSVSWNGVPVELEFASADGGAQGGVLVGSLQMSTALAQVTVPALTGWRYNDSLPEVLSNYSDAEWVVANHTTTNIPAMLYGDGRVLYGCDYGYCENAVLWRGHFEGTGSETSVNLTINGGTAFGATVYLNDVFLNSTYDISAEQTTELYTFPPGSVQVGQDNVITVVQDSSGNDEDANEKSPRGIPGFQLNGGNFTVWKVQGKLGGYMNYPDKVRGVLNEGGFYGEREGWHLPGFDTSSWTARELTEGLPGGGPGIGFFVTTFDLAVPANSDVLMSFQYDTSSQPYRAQLYVNGWNYGKRVANFGPQTNFPVPQGILNYSGTNTVAVALWSMEDTPVSPTLALQVDTVIEGGVGAIALNNPGWTPRPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9U5</accession>
    <name>A0A401G9U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0201000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609816.1">
        <property type="nucleotide sequence ID" value="XM_027754015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9U5"/>
    <dbReference type="GeneID" id="38775820"/>
    <dbReference type="InParanoid" id="A0A401G9U5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="66" mass="7228" checksum="8C5E788D914363D4" modified="2019-05-08" version="1">MSCTKPGNNIVKRAALCFAGQFHFTVQLRTGGPPGCQSSSSGSFGELCRGRVSTHLLQIRWDFNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAA1</accession>
    <name>A0A401GAA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0202920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610008.1">
        <property type="nucleotide sequence ID" value="XM_027754207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAA1"/>
    <dbReference type="STRING" id="139825.A0A401GAA1"/>
    <dbReference type="GeneID" id="38776012"/>
    <dbReference type="InParanoid" id="A0A401GAA1"/>
    <dbReference type="OrthoDB" id="3250101at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF440">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="259"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="411" mass="46977" checksum="D9BCDA49521DE1FF" modified="2019-05-08" version="1">MLWLKCLNLMINWETGDFWFGKDAKWPPKLTVKDASDEEVSIFKEDGLPELITTETSPTSFGHSESIREIMADNTERGELPAVRNDTKPDDPLSEPPIDQLDDNDLVISYIAGEPVIGIFEPIRKESPLTDEETETAVFTIRRGPAIGRMTHSTQSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPCDCKVYPLSLKEQGAMNDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLLLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGTFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVRTRRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB67</accession>
    <name>A0A401GB67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0206180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610333.1">
        <property type="nucleotide sequence ID" value="XM_027754532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB67"/>
    <dbReference type="STRING" id="139825.A0A401GB67"/>
    <dbReference type="GeneID" id="38776337"/>
    <dbReference type="InParanoid" id="A0A401GB67"/>
    <dbReference type="OrthoDB" id="3095879at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072:SF52">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="200" mass="23349" checksum="04616CBB8E9B5854" modified="2019-05-08" version="1">MLNPAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNHQQARWSLKLSQFDLHLIHVPGTQMIQSDVLSRRNGLDDSESDNEDRILLPDALFMRSISPTLFDEIRNHAAKDLIVYEVLEAIAHKGPFPMKSSLSDWEVRNGVILYKRKIYVPPSNRVKSNKVAQSQMVHRRSRMGRVHLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBT7</accession>
    <name>A0A401GBT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0207930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610506.1">
        <property type="nucleotide sequence ID" value="XM_027754705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBT7"/>
    <dbReference type="STRING" id="139825.A0A401GBT7"/>
    <dbReference type="GeneID" id="38776510"/>
    <dbReference type="InParanoid" id="A0A401GBT7"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF63">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64801" checksum="D76F71BC4C3ECC8F" modified="2019-05-08" version="1">MSERSIGRYDVPQEEKASSQRLSTMPTKANASESTGAEMSVPTGSPIHRRLAVVVIPPLRIQRHKKTPITPITQKTVDCQNSQLAPHVSHFAVMRKSITNLGDREVSPPIQHEDVSLAIQSDADASSLVKGHESLNRADLENIMATTAAAEEAWDAYQALMALPRRDNLLPIPYAHLHRLTRLLASTRPRTRALLLRLLSVLSTLHVTGGCVRVWQWNALIDCAGKGWRKTRLEDFKAALDVYEDMISGRRPGAAFSRSEATLAMEREVFDDAHREEVRPDIITFTTLMNIAGRTLQENALRRASSMLEASGLAPNRITHLALIRYYTRKNQLSGVRTTLSRMRDEGFELGIDGLNACIWAYARNGRLDVSSAVYRILLHRVAPEDDLGQDDIDTAVKYLYTTEALSIPEGILPDATTYYTLIQCYSYHGDLVRSLQVFMDMVSLSTRSSLTDGTEETDLSSPTLPAFRAIFLGFARHGTPSPNTKGAELLSSRLKSSMWTSDNLHALFQSFLKLPHNVQPSERTIFWVLMAFATTSGHDARKLRKVWEQLEERFGGGWGGRLERFRQRIYENQKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBV8</accession>
    <name>A0A401GBV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0208760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610589.1">
        <property type="nucleotide sequence ID" value="XM_027754788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBV8"/>
    <dbReference type="FunCoup" id="A0A401GBV8">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBV8"/>
    <dbReference type="GeneID" id="38776593"/>
    <dbReference type="InParanoid" id="A0A401GBV8"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="8"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="57"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="148" mass="16554" checksum="CBDEA438ADE9CBB7" modified="2019-05-08" version="1">MDIRLLKGKTNKVTLAVWQGGRKHVACLRTIKSLIVNMITGVTKGFQYKMRAVYAHFPINCIVQNDGMALEIRNFLGEKIVRHVNMLHGVSVAESKAQKDELIIEGNDIENVSQSAASIQGVCRVRNKDIRKFLDGIYVSDKGTIVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBX5</accession>
    <name>A0A401GBX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0208550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610568.1">
        <property type="nucleotide sequence ID" value="XM_027754767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBX5"/>
    <dbReference type="STRING" id="139825.A0A401GBX5"/>
    <dbReference type="GeneID" id="38776572"/>
    <dbReference type="InParanoid" id="A0A401GBX5"/>
    <dbReference type="OrthoDB" id="3363802at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="365" mass="39964" checksum="0B9EC195D8568CFE" modified="2019-05-08" version="1">MADLPTARELELETLLRQRDAQVAELTDEVAQLRQYLSTQPAPSTTDPISLPPALVSLLLPHINDRPLNNATATSNSVTAALTQRAKVLQEENDELYELLKTGETGRLKEDVRALRRVVQKLEGALEESHQVIASLSSELDKSHEAVMASGRLANAPSIHAPSHSPTPRNVYQAPPHLVSATNGKPLPTGPRAHKKPRLSESHTPPARSNVSLPPPTKTFATNANSIPIKDVRGRRGSTDKKPPANNVDVAEDQRKRPRSPEPERDRDRVRGRDKDKEREKETEPDRDRARERDRDRGRDKEHERDRDRSSRRTGGRSYMSNSSAGSGGAQSVAGGGGGRRGRGANNGNAAYPGGDRTLAERMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC86</accession>
    <name>A0A401GC86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0209730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610685.1">
        <property type="nucleotide sequence ID" value="XM_027754884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC86"/>
    <dbReference type="STRING" id="139825.A0A401GC86"/>
    <dbReference type="GeneID" id="38776689"/>
    <dbReference type="InParanoid" id="A0A401GC86"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="160"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="446" mass="49201" checksum="08DD5BC84838CC01" modified="2019-05-08" version="1">MGIEIESYAPEPITLAVIGCGNRGRAYTNYALQEPARCKIVAIAEPRPKTRKLMTDAHLVDQTLVFHSYQDLLQASAETIKTVGKRLADAVIVAVQDQMHLEVVLAFAEQGYHVLCEKPMATSIEHCIKIEEAVKKAGIIFGMGHVLRYSPYNKAVTDVIRSGTLGELINVVHVEPIGYFHFAHSYVRGNWAREEESCFALMTKSCHDIDILCHWLSPGTPTRVSSFGSLQHFRKERKPKEAGDATRCLDCTNESDCPYSAKKIYLDAVSKGKTTWPVNVLVDGIPDIENITDALRHGPYGQCVYESDNNVCDNQVVNMEFSTGATVSFTMIAQTEKICERQSRLAFSHGEIVGDMNTFTVCDFRTGKTTLHTPKNEGGGHGGGDLGLIRTFIEAVLTGRQELLGTDVSDVLKSHLTVFAAEQSRRDSAVVDCAQFEREAKARVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCF8</accession>
    <name>A0A401GCF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0210560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610767.1">
        <property type="nucleotide sequence ID" value="XM_027754966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCF8"/>
    <dbReference type="FunCoup" id="A0A401GCF8">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCF8"/>
    <dbReference type="GeneID" id="38776771"/>
    <dbReference type="InParanoid" id="A0A401GCF8"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="802"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="11">
        <location>
            <begin position="75"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="12">
        <location>
            <begin position="671"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="922" mass="100294" checksum="D2C6C2D258F09CDC" modified="2019-05-08" version="1">MTRLLVSIGLFSVLSTALLYLAGVDIVQTLSPQGCRMSWMSPSYVLQSAFDLQWSPLAKRYSLWLYREVGWEPNELHGSPVLFIPGNAGSSHQVRSIASSATRQFYTSPYQLSSEFSSSLYKPLDFFTLEFNEDLSAFHGPTLDAEKNYASAAVAYILTLYPSNTTITVLGHSMGGIVASALLPHPNISAIITMSTPHTLPPARFDRRVDTIYAENQVRLADDPTPILSLCGGATDLMVPSESCILPSEGELVYRRSVFTSALEGSWTGVGHREMVWCHQVRWRVARAALELQVASTPSERGAVLDTWIRDGHRLSPAISLGSDILDLNIEPAHEVVAAGQRLLVRDPRGSRMYFLPMPARTSKFVLYVSRGSILSISPRAAIPLSVSVFLCGGEATCTPLHPTSLKLVPSPVPGLPFPVPREGADESEGVVVFEADAVVGEAVAVKVENGDGRGWVVGEFIPANIVTSEVGMFGILFSTVSISLPEDTLYSQISFPILLSSSLIVYQLTPVSVPEKSCKDVLLSPILQHTSHPSETHYYPLHPSARPILLHSHASGPFISRPARGFTLTIFSSGENACNINRLKIRFSWWGTLGRWGVRYGTAAASWSVGVVALVIFHAWSLTDASGRTPSVSLALSHFAHQRLPQLLFLSLAISFLPLPSGFWLGNVGELFLVPLAPLLLLIVTGLVCLTWGMLTVLVSLFNKVTSVFRKPREDTGSRTNALLSMALVCLLIFILVPWQVAFLGCYVYHFYTCVARLPRTPDASPASPSTPVTADMTPVGNGAPPTRLVAELSVQSQHEYLLLLMTWLLPLAAPILAVWVRTLATAGIMARWDADHNVFCVAPFLVAVEFASVGGSLFQRPFSGIYAFSPRWGMLVLAAVAFLVGPRSTYLVFEVASVVVGIPVLLRLASWDLLGRSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCX5</accession>
    <name>A0A401GCX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0211650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610876.1">
        <property type="nucleotide sequence ID" value="XM_027755075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCX5"/>
    <dbReference type="FunCoup" id="A0A401GCX5">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCX5"/>
    <dbReference type="GeneID" id="38776880"/>
    <dbReference type="InParanoid" id="A0A401GCX5"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="162"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="928"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1019"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1029" mass="115206" checksum="CD34C2BD354E2D1C" modified="2019-05-08" version="1">MHLYLTESPRTLYLVTSSQEERHGRPHRVLVFRAAENSPSQAVVEFLPKDQVDLLNAVRLTTRVVKGCLGLISVSNDIFLAVVTAATELGNARPSASSAETVVRINEVAFFSLTSCTWDDLSWTTDSVSNTALLEQTDSILRDQYSASGSATPVFEHPCAPLTKIISSGTFYYALEPQWDLSSRLSSRLGRSDGNDGRRDLGTYDERFVWNEYVVRSLLDFRERLDPHEREELDRCQFIVLAIQGYVGLFRLPLPAPPTNGSPTLATLSLISRLGWKRSGTRFNTRGVDDDGNCANFVETETMFSTDQHCFSYVQVRGSVPLFWEQQGLQTFGQRIQITRPQASQPAFDRHFAQLTEEYGNVHAINLLGNKENEATLTAAYARHLQLAQGVLGDTIGITHFDFHSAVKIGGHESVFREIRRLDLLRENMDKFGFTMVDSSSDEIITDQKGIFRANCLDCLDRTNFVQDILSRTTLEQYLMLSRIEWLKSGTLWSYHRELWAENGDALSRIYAGTGALNTSFTRSGKRTLAGVLSDATKSVSRAYINNFQDKGKQIAIDIFVGNMSNQMQVTIFDPIHDSVRAALAHRISEYSTTKQCNIFVGTWNLNGRSPSSESLLPWLFPRPSNPDPDMLVLGFQEIVPLTAQQIVQADPEKRRIWEAKITDTLDKRPDKKTDYVLLRSHQLVGTALLVLVKSELAAVIRNVEAATHKTGLRGMSGNKGAVGIRLDYHDTSFCFITAHLAAGHANVDERNADYRTIARGLHFLKGKTIDSHDNVIWLADTNYRIDLENERVRHLALSDDFDALLAADQLKQSMDDRTVFVGYQEGPILFRPTYKYDFGTDNYDTGEKMRIPAWTDRILFKGNQLDLSVYSRAELKGSDHRPVFALFHADVRIIDHVKRAALSRLLFESVTSTAPGEKLDEKLAKMTLPSDASRLPPPSSDDAVWWNDPEHPDGIFVPSGPREASRKCLANPFDSPSNSPLSSSPSSSEEEIYHTLALQAPMAPVQAARRPPPPPPPRSHKPAHNNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDL7</accession>
    <name>A0A401GDL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0214770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611173.1">
        <property type="nucleotide sequence ID" value="XM_027755372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDL7"/>
    <dbReference type="STRING" id="139825.A0A401GDL7"/>
    <dbReference type="GeneID" id="38777177"/>
    <dbReference type="InParanoid" id="A0A401GDL7"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="123" mass="13217" checksum="24FF27C5174EADE3" modified="2019-05-08" version="1">MASPMARTTIPACVRRVEDNYLFIGSIVSPSVLLKTIRVEEDIPEEDVEMTSAPAMVVDSTDGMDLDDDDDLYGSSQVQEVLSINGNGNLNGVAVTSKRRTVVHLSLCDSLSAHGPISDMTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDW9</accession>
    <name>A0A401GDW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611282.1">
        <property type="nucleotide sequence ID" value="XM_027755481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDW9"/>
    <dbReference type="STRING" id="139825.A0A401GDW9"/>
    <dbReference type="GeneID" id="38777286"/>
    <dbReference type="InParanoid" id="A0A401GDW9"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="63223" checksum="0E6BD9F9C7F087C7" modified="2019-05-08" version="1">MDLLNLARSSKPLRDILLSRSLVTAWKKARSNVKDLPDCPPDLDEPGYANLLFLPHCHFCFNAKVFKPMWRSRVRCCKACFDSNFVDMSGALRFLYPHAAETERPQSLQIIAGDIYNHRRNYLKARVAVLRSCLQDVGNNEEKSRAFEEQMIESSKAVEMHARLLEKWHYDQGIIRAKERDDIRTKRCEAIIQKLQELGYGDDLKTMDRDMVRAFFNHQKVKQPKQLTERVWENIKEDILQFVLHARAVHLSKSRCERLIMQIQAAAKFYMTFILRRPHTELLPSFGDFCMMPEVLAILGRPSIGLAKSFEDLSPLLVELSDRWHLECSFKLMTLLPASVKQMNAEDISPLGLATTWFFCSSCQNLVGFPRILIHACMNKCTMNGDGALDLTYTHQADVMNTVHLLFGEQPWHIVTGSLRFHQVSCSTITNITMICGKNPAVVTAREMDELDARFICLKPRCMTHGHVCVVTWRTAVLHEKIFHPEGGTSWSILNTEDITMKRSCNTTLGMTLNTREKDMTISYTMTQILILAYLSMCHWTTLVRRLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEG5</accession>
    <name>A0A401GEG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0302300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611428.1">
        <property type="nucleotide sequence ID" value="XM_027755627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEG5"/>
    <dbReference type="FunCoup" id="A0A401GEG5">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEG5"/>
    <dbReference type="GeneID" id="38777432"/>
    <dbReference type="InParanoid" id="A0A401GEG5"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE80515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="354" mass="40181" checksum="8A9768A43AB993D5" modified="2019-05-08" version="1">MGCVQSSGVDDEAKARNDEIESQLKRDRMMAKNEIKMLLLGAGESGKSTVLKQMKLIHHGGYSESERDSYKEIIFSNTIQSMRAIVDALPSLDIQLSPPNDARRSVILSLPVQIEGDILPPDVSDAVRGLWNDPGVQEAVRRSREFQLNDSAVYYFNAIDRMAAPGYLPTDQDILRSRVKTTCITETTFKVGELTYKLFDVGGQRSERKKWIHCFENVTALVFLVSLSEYDQMLYEDESVNRMQEALTLFDSICNSRWFIKTSIILFLNKIDLFAEKLPRSPLGDYFPDYQGGDNYDAACDYLLHRFVSLNQSAATKQIYAHYTCATDTQQIKFVLNAIQDILLQIHLRDCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEH5</accession>
    <name>A0A401GEH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein pim1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0303090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611507.1">
        <property type="nucleotide sequence ID" value="XM_027755706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEH5"/>
    <dbReference type="FunCoup" id="A0A401GEH5">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEH5"/>
    <dbReference type="GeneID" id="38777511"/>
    <dbReference type="InParanoid" id="A0A401GEH5"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="17"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="153"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="208"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="265"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="327"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="390"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="445" mass="47015" checksum="01DB48F500F150D7" modified="2019-05-08" version="1">MNALPAPPAHLRPPLLLFGWGEGNSGQLGISEDFTGQLDKPWRNRYVEQSIAAGVFGEPGAGLEAIAAGGLHTLFVDEKGTVWSCGANDNAALGRVTVNVPDPKNDKELLEVDKRTGQPTTVPVPIQSLVDESFRAVKVVAGDSVSAAISDTGELRVWGTFRGNQGLVGFSSGSQLQFRPIPVLDLPSEKVVDAAVGNNHLMLLTTRGNIYTLGTGEEGQLGRRVIERRKLHGTVPEKIILGNRTRKAVVIGAGNNHSFAVDTEGTTWGWGVNSKGQTGTGMRSPHIDLEVHTPKKVVGLTKADLNGATVVQIAGGDLHTLFLTSDGKVYACGLSGEGRLGLADDDPAFRNPPFPGFLAEPALVTFPDDDDPVVQISCGTNNNLAVTRNGALYSWGRQVVGELGLGHDEDVKTPTVVVRREGGSWAAVAGSCGGQHALALLRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEV3</accession>
    <name>A0A401GEV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0303500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611546.1">
        <property type="nucleotide sequence ID" value="XM_027755745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEV3"/>
    <dbReference type="STRING" id="139825.A0A401GEV3"/>
    <dbReference type="GeneID" id="38777550"/>
    <dbReference type="InParanoid" id="A0A401GEV3"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15499" checksum="E83CBA23FF93082D" modified="2019-05-08" version="1">MVACSTANHDLDYMRLVNLFSIFYQIRDDYANLPNAKEYTVHKGYAEDLTEGKFSFPVIHGINADPSDTRILNILQKRPSSPTLKTHAVAYLSDHTKSLEYTANTIRVLEAQIRGEIRQLGGNHVWEAIIDGLHIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEX0</accession>
    <name>A0A401GEX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0304630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611657.1">
        <property type="nucleotide sequence ID" value="XM_027755856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEX0"/>
    <dbReference type="FunCoup" id="A0A401GEX0">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEX0"/>
    <dbReference type="GeneID" id="38777661"/>
    <dbReference type="InParanoid" id="A0A401GEX0"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="475"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="783" mass="86689" checksum="681CA99D26A67A39" modified="2019-05-08" version="1">MLMPSSAKLPHKNTLEIRLAENVVFLRAGDATGRLRSIQADAPPGMLRGLLTLTLVKPTRISSIEIELMGKTSTAWPEGIGARRIDISEEHDIYSESYVLFRAGSSPFSSRRTLSVGPGLALDHEDEDHSDHSSEQLDAARTPEEQRGRDRGPPSAGFNRATRRHLSVDQTTFQRGFVSHRENSGQLPPSPQSPAYSPEATPQYSLSPRNSISYRMHTLEESPPRSPDSSRMTYGDSDADHRSTFSGRSQSLVPESTTFSFPQDGLYSGRPSLDEDREFQVGNSTGTLQPRSLSRLAPRREPSRSSEGTEMGSGEDARGRKHKRFSFANVSSVLLDAVRDHVRSRSPMIEQFREATPPRGRAVERTLERPDGAPAGPMQARLRGYDGESAEEIGDGWKEFRKGVYTYPISFAIPAMSPPTLNCDYGTVSWNLKAYAHRPGTFTSKLSATQEITVVACPGEDDTEESESIIVERQWETQMQYLISISGRCFAIGGVMPVTITFMPWTKMKIHRISVLIEEKIDYWTNFKRVVRSDPLARVSLLSYKSPQKDGPPILPLNPDDPDAFRNSPFVDVVGADTDVGEFASSLMGPGPWTLHKDISLLKEHTPLHFTNKNRRSNMSVSHTLKIVFRVERGDNEALDPHTGKRKLFDIVVQTPIHILSYLCNPEHLSLPPYSRVMEPTPGTTLHWTSLPGSATQLNGDRSRYTSLLSPGPVTHADLGFSAHSSTTTSEQSLSMSMSPSHTGAAFEPDSIYDRSTQFERLVAGQESEIGEAPPSYEAVVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF90</accession>
    <name>A0A401GF90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0305150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611708.1">
        <property type="nucleotide sequence ID" value="XM_027755907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF90"/>
    <dbReference type="STRING" id="139825.A0A401GF90"/>
    <dbReference type="GeneID" id="38777712"/>
    <dbReference type="InParanoid" id="A0A401GF90"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="615"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="35"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE80795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="642" mass="71023" checksum="1F11B6B457E21382" modified="2019-05-08" version="1">MPTVFHREVAHKVSDLESQQTVSSIAENRAEHHALVWKNVSFEVSKKGVKKTILSNLSGYVSSGEMIAIMGPSGAGKSTFLDLIAQRTQPSSGAIELDSTAKFRMRDYSSYVEQDDALLGVLTVRETVEFAAKLSMPASTPPEVVRQRVDSTLTMLGISHVADNIIGTAIQRGVSGGQKRRVTIACAVVARPDFLILDEPTSGLDSATSTEVVRAVQRLTQTTNSVTLCTIHQPSYETISHFDKVLLLANGRTLFFGSVTAMEEHFSVLGYPTPTHFNPTDHAMTLINTDFTSLSTLDSDLRETKENVIARYDTFVNAWQICERSDPSIVSPLCGVPNTLSPPKEGGKINSVPQDMYRTWVLAQRTFLNYRRNILNHGIRLAMYIGMSLMLAVIWIRLPKDDQRINDRLSVHFYGVAFLSFMSVAGIPSFLEERSLFIRERDNGLVGPGAFIISNTLVTLPFMFICAISFSLICYWAIGLHPGATAFWRFTFFLFLATIAAESQSVLVAAILPIFVASLAVASFMNGFWMSVGGYFMQTRNLPAFWRDWAHWIDYQNFAFANLVKNDFTGLVFTCQTLADGSCQCSYASSLIAQGQCAVSGQDVLDQLEIAGIDIGLYTGILICIIAVYRVMLYLALVLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGG9</accession>
    <name>A0A401GGG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0309890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612175.1">
        <property type="nucleotide sequence ID" value="XM_027756374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGG9"/>
    <dbReference type="FunCoup" id="A0A401GGG9">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGG9"/>
    <dbReference type="GeneID" id="38778179"/>
    <dbReference type="InParanoid" id="A0A401GGG9"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="270" mass="28333" checksum="DC78B0037016D40F" modified="2019-05-08" version="1">MESKLKALKVVDLKDIIAKANLSIQGKANKQDLINKIIASEAAIDVYNANYSAKKSPSPPKAAPVHKKTDASPQSDEQLNLLEVVDNVLPAEQANEPPSHAGVQSDASVTLSTAPTPPSKTTEIPAASADTPQPEPAAATSPEDEEAAKRKARAERFGIPVVQLDAKPVSPKGNTRGRGAGKANAKVEQPLPDDPEKLSQRTARFGPVEPAPAATSTATRATPKTGATKGAQTNGRKRSAPATETVDAEELERRKKRAERFGIPVVGAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGR0</accession>
    <name>A0A401GGR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612283.1">
        <property type="nucleotide sequence ID" value="XM_027756482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGR0"/>
    <dbReference type="STRING" id="139825.A0A401GGR0"/>
    <dbReference type="GeneID" id="38778287"/>
    <dbReference type="InParanoid" id="A0A401GGR0"/>
    <dbReference type="OrthoDB" id="2758081at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="212" mass="23757" checksum="6B3D38B70453B636" modified="2019-05-08" version="1">MGGYCNLPQDERYLHIGYAAKDSRQEEFVLKVVSKTRKELTIIQYLNSPALLPDARNHTIPLLESLNVNADKCILIMPRFLPLSRLSAWTTPHECIRILIQVVEGVSFLHEQNIAHLDIKDTNFVVDIDTGRVYIIDYGLARRIQGPEDEVEGFRGTEDWVAPEVNDNLPYSPQTCRSVGGGRAAQAYAYYSPQSSSRSKDASIRIGATFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGS4</accession>
    <name>A0A401GGS4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0310950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612281.1">
        <property type="nucleotide sequence ID" value="XM_027756480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGS4"/>
    <dbReference type="FunCoup" id="A0A401GGS4">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGS4"/>
    <dbReference type="GeneID" id="38778285"/>
    <dbReference type="InParanoid" id="A0A401GGS4"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE81368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="441" mass="49167" checksum="6A04EBC8D17FC3A7" modified="2019-05-08" version="1">MPLAVPSKSWFQYLLPSFKLDDTKHHLDVLRVLSVLTWFLCAIVVHITSLFPLFDSSPHAALPASSSSLLHSLSHPLLRWDAFHFGHIAQHGYVYEYEWAFFPGTPLLMRGAASVVRLFEVRSASPETPGWEDVLLGGALAACLCSSTTTLYRLTLHHFRSPSLAFLAALLSLLPSSPATLRLAGYSEPFFTYLSYRGMLYCTRSQWFFAACTFALAGMFRSNGILLSGFILWGVLVEPFLTTRKVPFKKLAYAVALTSLTVMPFVSHQYTAYRAFCGGSATPAPWCISVPPLIYSYVQAKYWNVAFLRYWTPQQLPNFLISAPILALLFSYTTFYILHALIPRLHSLLLGRPSGRSLPASPFLASSLAPHAIHALLTALTLLFTAHTQIVLRFAATMPLTYWAAAWLVVEHPRWGACWVSWSVVWGATMLVLWGAFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGU1</accession>
    <name>A0A401GGU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0311110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612295.1">
        <property type="nucleotide sequence ID" value="XM_027756494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGU1"/>
    <dbReference type="STRING" id="139825.A0A401GGU1"/>
    <dbReference type="GeneID" id="38778299"/>
    <dbReference type="InParanoid" id="A0A401GGU1"/>
    <dbReference type="OrthoDB" id="10261040at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130">
        <property type="entry name" value="34 KDA TRANSCRIPTIONAL CO-ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13130:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33815" checksum="16BA88E2A4B2EC8B" modified="2019-05-08" version="1">MSATVENHSTPPVPTDVNALQDKLKTLTEFSARLRALRQIPAVLVRPPGAGSIHTVAPSPPLQHEFQVLNEVSGTLLSQPVQEALAAARDSEQKDKSDINSTVRRETQKRKRPPSPESPQPYRPFEPKSSSSFPEIDQGLPPVRLGTLPGFIREYNGADHAVKMHVYSPSRNRPLACPVVLRCMIRDVVTVFLTLGESATGAPLDVECATAFGPREQEPSHSQSQYLVYQNLSQQIAKMIQSQPQTSLRAVLNLLCSYEELFVQRCAVCDRILSVEAYVPPVGRVWTKMGDGAFGWEARHATCLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH97</accession>
    <name>A0A401GH97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612404.1">
        <property type="nucleotide sequence ID" value="XM_027756603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH97"/>
    <dbReference type="FunCoup" id="A0A401GH97">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GH97"/>
    <dbReference type="GeneID" id="38778408"/>
    <dbReference type="InParanoid" id="A0A401GH97"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="14149" checksum="EC4A51A6A69F5EFB" modified="2019-05-08" version="1">MPFYQMLCISSHYPEYKHIKDLVHFTAMHVMNQGGVVRRLNSWGTLSLPQRMRRHKTYNSIGDYWTMHFDASPRILKSLNTQMRRDPRVIRCTMIKLGQKVEDVVHEKEKTIQRRGSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHQ4</accession>
    <name>A0A401GHQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0400220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612564.1">
        <property type="nucleotide sequence ID" value="XM_027756763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHQ4"/>
    <dbReference type="GeneID" id="38778568"/>
    <dbReference type="InParanoid" id="A0A401GHQ4"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="37793" checksum="17EA08FF65CF9AFE" modified="2019-05-08" version="1">MWRFTSYPSEPYLSSVAAHLLHKTPGALTTVLACLEGKLDSGMIAVGQSGELVSRLLWLLGKDLFATQSFDETTTRNQELLYCRSIPVLPFLEFFFGMKFWPADDEQKTAAREAFKNARINFSHWVAMSDNISKEGVKWNPREWILRHWYRTCAIQCCHGQPRTDKMIPMYFDDFSGRNDQDRMSSIFISDKAGENDSPRDVNFIDRTHDSINCSTSRPYIAITLDLGVQDESITSTFPTSTSERVNAGVDNRCLRIYARGMSAETYPFLNKVEGLFQVMKQVAVRERAPLYPSPIEARLQDLFKYGSTSSERHMKWEAGRDPRLLFSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHW6</accession>
    <name>A0A401GHW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612661.1">
        <property type="nucleotide sequence ID" value="XM_027756860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHW6"/>
    <dbReference type="GeneID" id="38778665"/>
    <dbReference type="InParanoid" id="A0A401GHW6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="60" mass="6375" checksum="AE96DEE4C781A298" modified="2019-05-08" version="1">MQLEGLPSGAATGAVPDWSNPHIARGVDDTGSCTPNALNTLLDSEAMRSKYLVYINTLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHZ2</accession>
    <name>A0A401GHZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0401140</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612656.1">
        <property type="nucleotide sequence ID" value="XM_027756855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHZ2"/>
    <dbReference type="FunCoup" id="A0A401GHZ2">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHZ2"/>
    <dbReference type="GeneID" id="38778660"/>
    <dbReference type="InParanoid" id="A0A401GHZ2"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="210"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE81743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="542" mass="58012" checksum="14F6107F0A7314D8" modified="2019-05-08" version="1">MLTSRGVHRLSRRALNSARKTNALFSSAAVAPILSRAAAVPSSSHRAQARPTRVSAPAARTYATEATGTIGQVKTVIGAVVDVQFDTENLPPILNALEVTDFHGGRLVLEVASHLGENAVRTIAMDGTEGLVRGQKVVDTGAPIKIPVGTATLGRIMNVIGEPIDERGPIKGVKLSPIHAEPPPFVDQSTTAEVLETGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIQELINNVAKAHGGFSIFCGVGERTREGNDLYHEMIETGVINLEGDSKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLSTDMGGMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRSIAELGIYPAVDPLDSKSRMLDPRIVGQEHYQVATAVQKILQDYKSLQDIIAILGMDELSEEDKLTVERARKIQRFMSQPFAVAQVFTGYEGRLVPLKDTVRSFKEILSGAHDSLPESAFYMVGTIEDVKTKAEQLAKEMGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI21</accession>
    <name>A0A401GI21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0401340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612674.1">
        <property type="nucleotide sequence ID" value="XM_027756873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI21"/>
    <dbReference type="FunCoup" id="A0A401GI21">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI21"/>
    <dbReference type="GeneID" id="38778678"/>
    <dbReference type="InParanoid" id="A0A401GI21"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="327"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="502"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="552"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="593"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="806"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="665"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="834"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="887" mass="96454" checksum="A543738314D8D210" modified="2019-05-08" version="1">MRREYIELVQTRLHAAISLFLILSPAPFPSFNPQFGRTNSERRPAPNIVTIDSLAELNPTRYTTPHQAAALDPSEPISPSFASPSPTAHTASRSSTSPATLVPSVRSRAELEDSESDSAPPSFAAHSSSPAPLSFLHPSSSGANVARPASPVTATQPEPDPEHSRARKRQRIDSLSSSASTSLTAIERALFAESSSSSLIYDSATMRPPEADQESALSVSFDSSPVAGPSSAVGASNGHNGAAKTNGFSQPFTNGSSKSLLSAELEEHRAARNGTSVARVSLPGSTLYDDSYVDREEFVRLVIQSLRDVGYIESAATLEAESGYTMESPEVSEFRKCILDASWDSAEAALMRLGVADDERLWEAKFLISQQKYLELLEAQETTAALQVLRNELAPLNVEPDQLHTLSSLMMCSDPDDLRQRAGWDGASGSSRRQLLVNLQRYIPSSVMIPQRRFATLLDQARTWQQSRCLFHNAPLNSRTFSLYTDHRCDKNTFPRVTTAILDVHKDEVWNLEWSHSGNYLATASKDKSAIIWRVEFDQEPSVREYSSVFVLGDHPFPVGCVAWSLDDTILLTAAEQIIKLWNARTGQCIRTLEAHTDVVTALEWLPDGTGFISGGLDRKIILWDADGKQRDSWGQTPIRVTDLAVTPDFTRLIAVGMCDVLIPPTGPNVTPPEDGTPPGGSGAPGGRTSENRVIIYDLATKQPETSLGLQGELTSVKTSQDSQYVLINRAGDGLVCEIQLWDLATERVVRKYTGHSQGKHVIRSCFGGIDGNFIASGSEDGNVYIWHRDTGTLLHTLSGHGAGSVNSVAWNPRNERMFASCSDDKTVRIWEAPPTDVLGSPAGSTEHLEQENGKGKGKGREQQWDGNGVDDEYRPSSASASAPTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI30</accession>
    <name>A0A401GI30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612678.1">
        <property type="nucleotide sequence ID" value="XM_027756877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI30"/>
    <dbReference type="FunCoup" id="A0A401GI30">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI30"/>
    <dbReference type="GeneID" id="38778682"/>
    <dbReference type="InParanoid" id="A0A401GI30"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="1">
        <location>
            <begin position="214"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="288" mass="31855" checksum="5117408A4AE08C5C" modified="2019-05-08" version="1">MTSSLSLPASLRQFFALFPLYTHGPVLSPYTAKPVRSPTLWIHSPWDAEADVLSSDVECLKWQAYLALRGVTDVDVRWDMASEGAIDARLPNLHVPPKEGEAGGGDLLPAHLIREWVDGRVGGGEGPLEGYVDEAARDEGRAWVALMEGNVHAALTISEPPSFNLWNILSPYSEKPRSVETMINPPPAPFTGISSLLPPYGSHVDRATIELQYREAIASLSERLGTDKWFLGSTGPTALDALIFAYLHRILHAKDNTIRFEVTRRVNLVAWERRVQSQVRAAFQRIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI92</accession>
    <name>A0A401GI92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0402710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612810.1">
        <property type="nucleotide sequence ID" value="XM_027757009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI92"/>
    <dbReference type="STRING" id="139825.A0A401GI92"/>
    <dbReference type="GeneID" id="38778814"/>
    <dbReference type="InParanoid" id="A0A401GI92"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="11">
        <location>
            <begin position="525"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE81897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1175" mass="129817" checksum="1EB180B28088BE7B" modified="2019-05-08" version="1">MKRNTEGSADGHRKRPRVQEPEHAATEQHHDPFDASLKRDSSVLRADITDEQGYLEGKLKMRWPLLSAKSHIQLATNDGALLDIHFQGACSKYFSQLTFSIGDVIQLALKGVRVKVSGPGARRSHELTYEQGAIVKFLKAKDPAQNNRVVNTWKLDEEDTRTFARKPLDPNDWYSTPTLFTIDGSDNQERASSSASHTVPPPPVTDSRTAPSATTDVADSKNLATSSSVTAKPASRSEVQMNKNEDSAERSNGSESSTRSKRRRSPDRLSSKRTSEERGSSTTVAEPQSKPQPGSHPANCPQASSLIVLPANSKNDATEPQQRKDEQRMVPPTVSGPGSNVNADIAKETKQQKKARKKAERKLKAFRKERTLLVPGDSPDSASYIPTKSGESVSTNQANVNAPPLPITYEVVDPADKSALTHISNPTRVSPAPEPPVSTLSGHSETRDAPSDNSAVLHGATSSQLMNVPVQSALANTINTPSPASRTVISHIIDPSTASSTPLNSEDADSSAASKAGCWTSNGYYVPLSEIRERQTQNVIGVVTIAGRVAKTATNENMIKVIIVDPSNVETTGSGINCFSKANNWLPEPKTGDILILRQIQGDNHLGKLCGTAPSYKGWTWAIFDPRTHSTTGTSPFKPGEEEMHYCARLADWWKDVSKSRTSSDETGTIHHIIGPIGRASRVHRLICDASPQTEPSGFFDCTAEVLHGYNNDNGVYSLYITDYTRNPALTAVQRDWCPPQLADRVLKMEMWNSAAAKAPDIKVGEYWFFGNNRMKVSSGGYLEATISEANKMRKLDEDVLEGAPHLEALLQRKHDWGAAVQADGELFTHQLFQDIKPDHHFLCTVEIVYISHKSDTSCLFVTDYTSRSDLVPIAPTAPRASALKGMIVRIDLRSDTQVETAKNLTEGDFISIRNLRLTRSGGTEQLAGRLGGVERLINKLQAHDPTNEELKALLGRKSEWEVDYSRKMGRAVPPKRTGRASQRKEKPPVKLSCREKGFKTIREIECDEQCPTLFRICARIVDFYPRELRSWTVLRCTKCDKDLAEDYRRCAECDDAMDDKSYVKPVYEFFLRVEDEKGDRLDVSGCDEQGSLLKDLEAADFREDEIAYDKFIQRLAPLLGNLLKAEGSARRRFDDDFVPDTPLLALTVGMWPLNDGRGPPARGYVLQRHAVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ58</accession>
    <name>A0A401GJ58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0405250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613058.1">
        <property type="nucleotide sequence ID" value="XM_027757257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ58"/>
    <dbReference type="FunCoup" id="A0A401GJ58">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ58"/>
    <dbReference type="GeneID" id="38779062"/>
    <dbReference type="InParanoid" id="A0A401GJ58"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="134" mass="14354" checksum="1016760BF1D29F34" modified="2019-05-08" version="1">MAIFGLWVINKAGGLIYQRNIGDGLPNLTSNEYLVLAGTLHGIHAITSRLSPTGSSSGAHVISGETFKMTILLTATGTKFVILTSPVEPTAESMLQKVYELYADAVMKNPFHTPEMPIRSEGFDTKITALLGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJA1</accession>
    <name>A0A401GJA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="5">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0406230</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613152.1">
        <property type="nucleotide sequence ID" value="XM_027757351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJA1"/>
    <dbReference type="STRING" id="139825.A0A401GJA1"/>
    <dbReference type="GeneID" id="38779156"/>
    <dbReference type="InParanoid" id="A0A401GJA1"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE82239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1227" mass="135144" checksum="4955EA162CF14464" modified="2019-05-08" version="1">MLAKAPRRLPYLPRQGAARGLSIGCRRYNHTEGKKLTPWKVDATDQPSVLVEEDFAKHTIFTIDFFKRFIKFSAIGFITLGVTTWTAFQGVHMYVEHSELAAETDEEARKWEWDLEADRWSGGPAGGTDPGLGFTGRVAVRSAWIAQNWGIGTTSSVISSKAFSGRAGSGAGGLSAIDGSLEFAQDFLNAAIDAGMKKGPERLHPQTLTELIVRHASIMERMGTREALFEARSEFERVWAGLPGKGFDSTRIALKLGDLNQRLGDQEDAIAWWARAIQLSQGSNAAIISMPPPVPESAPLSPFAQRTLISTLVSLSAYYATSGQLKQAQALEESSLNLLRSMPTPASFEAASRPEALHAMYLLHRSSLLSIHLAEVSYALRMKPMTSLEWLSRAAESSERVALTLTGLPPVHPDAPQSRIPHPPSSETPLVSDYAKSRSMKKPAKSLLRDARRTAAEAWNLMGILVEAGSSPETTEKALECYERALGWAGVAADRAGQIGKAGDGTLESEWKILWANYVRARDATSNNFSQNHLRHPAIAERFLADRAAPLCSLDVAKSFTQLSSKEKKYAHYVGQASWAGARIIQDQWTPYAHKLHKLLLLTFSSGGRLADLESLKQRSAVSPEEWEDLMQYTSQVLSNLVNYRSFGFTKIVPRISQDTFAAVVEKSANASEALALWAELKDHIYQVVPESSNFIGKPRLGQVSNYYLGEPILDEEVAAVQAAAEKIGVDVLNTRVKKNGSDDFVLLVASAHPQPSSLHETEILGKGAKVSVEYGDFSPPLQNAVQALKEARKYVTNEHQAAMIDGYIESFETGSIPAHKAASAEWVKDIGPVVESYIGFVETYVDPYGGRAEWEGFTAIVDKSLSKKYDKLVNDAPELLKVLPWGKDFEVDVFRKPDFTALEIVTFATGGIPAGINIPNYYEIRESVGFKNVSLANILAAKAPDEELTFIHPDDVDLYNAWDTRAFELQVANHELLGHGSGKLFQENADGTRNFDASKIISPLTGKPITSWYKPGQTSGSVLGEVSSSFEECRAETVALYLVSNPDILRIFSYIDKTDVEDVQYITFLLMARAGLRALEFYDPATKKHGQAHMQARLGITQHLIKSGIARLEEIRSTDGTLENLYIRVDKEKVLSHGREAAGKLLLELQVRKSTADGAGAREYYTALTAPLPGWEGDIRDLVLKKKLPRKIFVQPNTFVENDEVVLKEYPLTPAGVIESFIERPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJV4</accession>
    <name>A0A401GJV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0408130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613342.1">
        <property type="nucleotide sequence ID" value="XM_027757541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJV4"/>
    <dbReference type="GeneID" id="38779346"/>
    <dbReference type="InParanoid" id="A0A401GJV4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="882" mass="97410" checksum="5C4C15AEE55A9779" modified="2019-05-08" version="1">MPARFVILTEHQPILSEKLRSYDTADAKGRKTLVQSLHQKLKTQFVNASNYDDIIVETKIQEWLNNHARHVQEKATKKRMHVSGKPNAFKVWDALERDKKVYEEKAESWRNGTLDDKMKMKLREQRMMQYLKKFAKTMWDTMGIRMAFMLAYPKEAGSLKVEMVEVNHAITNGTPFGAYPGWLRAYQPLAKVFSEWAKGEYGVTETTVTVKKTPADCMRAMDKIWLTANGFPLLPSVPEGMAEAPLKVMKVQVRDFMNHYYALAKGVRNCKSSWTKLNSIDDINEVIPAEMLPENFQWIDPSKMTSVPVRALLDHWRARQEEHGPEQTMRFTQYFDKDGEAAPAKYDPLPPLDGSAQALEEGSEHEVQEALTPKKAGKAKKKGKPVRKVTGKAASKATKGKVAPGGAKGGGRKCKTKDAYDSEDDARSSQDSDRSSPDIPSMASEEDTASDEDSGDGESMIANKVKGKAVATTNGRKANNGSAPQASGSGGAKTKAKRGLQDLPLGELHRFDTEETNEASSELEPSTKELRLELQGRAPRLTGGSTVGSTVPHLVKRRDVFLATLSIEPRYQDMLKQVKIATVPQVYHFARYDPIPWSEWSYGQRYLPLSFHAVDNFDIVENWLGDKLWLTKYRFLHPQGVQQSALVIGMALRDLTRSQFIEEGEPTNLPDYVVNSAISFDAVEQLLRCCEIITLDMVEGNVTHAMVKPVSKPAIRGAPQGGDGLGGQEEQEGDASARTHDGTATAAKVHKAHQPAPMADKPIIPSGEDEGPSQETSGGASDDGEEDDAHLSVPGSGAERPPPPPFIPKTRKAAATEDRPSGQAKALQGRSITDALQSNIPGRITRSQRQAMDESPAKNTRSQHPLGAVKDLKKLPDPKRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK64</accession>
    <name>A0A401GK64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0409340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613463.1">
        <property type="nucleotide sequence ID" value="XM_027757662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK64"/>
    <dbReference type="STRING" id="139825.A0A401GK64"/>
    <dbReference type="GeneID" id="38779467"/>
    <dbReference type="InParanoid" id="A0A401GK64"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11294" checksum="AF5393F73811D5D0" modified="2019-05-08" version="1">MKMRHHAQPGDPKDRGKDVPLIERLHVIVKCGDSTSTLWFRKTIGAGRALDLLATHFKVTASDSSPLRLAKTPVVDDDVVTLRTDQPLSEQVEDGSHLLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKC3</accession>
    <name>A0A401GKC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Set1 complex component ash2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0410060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613534.1">
        <property type="nucleotide sequence ID" value="XM_027757733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKC3"/>
    <dbReference type="FunCoup" id="A0A401GKC3">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKC3"/>
    <dbReference type="GeneID" id="38779538"/>
    <dbReference type="InParanoid" id="A0A401GKC3"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="107"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="606"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE82621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="648" mass="72294" checksum="2827B6EE3B05A9EE" modified="2019-05-08" version="1">MEALESPREPSPATHHLSAPANHSHKKRKHAAMVNVAASPAPSDLGATPAPTTENLVLPTRHLDLSSRPRLDISRHPMFVPIAPGSEYYNTEPLCNNRQNYRYTPAGLTPPDSAIAFRTIESAPTSYRVSWEDRSTFVKVTQDGLGLKGEKGFRSARCNAPVREGKWYMEIIVESGGGEKPPESQRRQGSHVRLGWARREAPLNGPAGLDGYSYALRDKTGEKVHLSRLRPYGKPVKSGDVVGMYISLPPHRKPDKRDSSDPAHIRRARIPIEFKGQEYFESLEYSQSKEMMELMNARERQKAENTNSMPSSTKKSATVKNIPSSSRGVKASQQEPNSMRPLPTLGPDSYVAFFVNGECQGIAFQDIFDYLPLRSSPNKTQEKSRRNKDGLREHRENPFDDGTLGYYPFISLFNEATVRINPGPDFLCPPPPDIDAVLSSSDWAGRDIKPLSSENAQTWRPISERYSEFIAEQHALDAFEEAEAQKNHVGNSAKEKADTEKAEKHREKRRAQAAARREKKAKQAKEEAEALEAAKRRKLDEERLTLGGEVEIDLHAPDFGANVSFPEIHSLPDTFHHYTSVGSPAPTVASSADFHIPGIVVRQGTSEYNSEYEDADGDIDMEAQVPEAQRDEDGAYRSRENSYPPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKZ6</accession>
    <name>A0A401GKZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0412170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613743.1">
        <property type="nucleotide sequence ID" value="XM_027757942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKZ6"/>
    <dbReference type="GeneID" id="38779747"/>
    <dbReference type="InParanoid" id="A0A401GKZ6"/>
    <dbReference type="OrthoDB" id="2585179at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="97" mass="10549" checksum="92DFC9D0A5FF4803" modified="2019-05-08" version="1">MSAPLALNHDENVYLTVTITSSSPFAVNPAALVVHPSLTHLGMVGQLRDVQLLSVPRESWPRLQGEVLSALNALDGVRRVDVQDPPRMRAKRGGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLN8</accession>
    <name>A0A401GLN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0501580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614024.1">
        <property type="nucleotide sequence ID" value="XM_027758223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLN8"/>
    <dbReference type="STRING" id="139825.A0A401GLN8"/>
    <dbReference type="GeneID" id="38780028"/>
    <dbReference type="InParanoid" id="A0A401GLN8"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="209" mass="22966" checksum="BE6FA73649A3B1DD" modified="2019-05-08" version="1">MTMVRPRTGDFLYSQAEFDVMVEDIRVFKEFGADGVVFGILTLDGRIDIERTALLVDEAFPMQVCFHRAFDMTRDPVEALFDISTIPHITRILTSGHGPTAPSGLSVLQTLLTKASGDGAGMPTILAGSGINVSTVRLLLDTLLPCGLSEIHLSAGMWIPSKMKHKPLGMGMGVGEGEWGVWRTSEERVSEVRSVVDVAWNDYLDLHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMM4</accession>
    <name>A0A401GMM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBCC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0505140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614378.1">
        <property type="nucleotide sequence ID" value="XM_027758577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMM4"/>
    <dbReference type="FunCoup" id="A0A401GMM4">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMM4"/>
    <dbReference type="GeneID" id="38780382"/>
    <dbReference type="InParanoid" id="A0A401GMM4"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031925">
        <property type="entry name" value="TBCC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16752">
        <property type="entry name" value="TBCC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="148"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="331" mass="36124" checksum="2F721CD535F9D9A6" modified="2019-05-08" version="1">MAETNQALIQEFHSHFQTMRSELTTRLEALKSGGATPDGLESLSLDVAKLRKELTDGTDFLPSYDQRQCELRLKNIEDTLENLRASSAPKPKFSFKRKVNKPAVSPSAAASVFESTPSAGISHLNTFPSSSLNLVGRSHIFLTWSSLPVRTSSASDLSIADLDYCVVNLLPSESAGQVDAKSFSITALHVRNISNSIVILPEIEGSALLHDLTRCVIVLGCHQYRMHTSSNVDVYLHVPSDPIIEHCTGIRFTGYPRSLHAAAYSPGSRIEPVPASNHLSVKDFSHIRASPSPNWSLLPEEKLIAEPDWPGSSKQDGANMDSVLDKLLPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMM5</accession>
    <name>A0A401GMM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING-box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0505150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614379.1">
        <property type="nucleotide sequence ID" value="XM_027758578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMM5"/>
    <dbReference type="FunCoup" id="A0A401GMM5">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMM5"/>
    <dbReference type="GeneID" id="38780383"/>
    <dbReference type="InParanoid" id="A0A401GMM5"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="46"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE83466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12842" checksum="436AE8C02ECEB223" modified="2019-05-08" version="1">MADMDVDPPASTVAKSGDKDDAKKRFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIDCQANQVSATSEECNAAWGICNHAFHFHCISRWLKTRNVCPLDNREWELQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN04</accession>
    <name>A0A401GN04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614508.1">
        <property type="nucleotide sequence ID" value="XM_027758707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN04"/>
    <dbReference type="STRING" id="139825.A0A401GN04"/>
    <dbReference type="GeneID" id="38780512"/>
    <dbReference type="InParanoid" id="A0A401GN04"/>
    <dbReference type="OrthoDB" id="5792673at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="58"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="209" mass="22690" checksum="905949E07A603F88" modified="2019-05-08" version="1">MSIRPNLMRGNVTATSQYITEPIYHSSVPANIRAHLRSGTRSTSPARQANAPCTSTGTLVAIRRIANLAHPACGQHGLFAAKKLAPRTHLLDYLGEVHCDARPHSDYDLALLRAGGAAVGIDAAHAGNAARFVNDYRGVCARPNALFEERWTEQGELRMAVWVGSEPVRKGEEILVSYGKMWWRARTAEASESEGTAPWDNALSQQSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNQ2</accession>
    <name>A0A401GNQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0508930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614749.1">
        <property type="nucleotide sequence ID" value="XM_027758948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNQ2"/>
    <dbReference type="GeneID" id="38780753"/>
    <dbReference type="InParanoid" id="A0A401GNQ2"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="235" mass="26057" checksum="3493C7A4FD6F2E69" modified="2019-05-08" version="1">MGDTIDAEAYKHWHPEYLDAKTMPYLKFIFRYRPRAILQAQGIIPAPAEDLDERTSDSADLETGISQTSSTNMHSQKDRSHSLNSVRGRKRARAADDDLGPRPKRRNEATSSQEGVHTGAPAAAEHGDAHTNDIKPMLGRPLQVQEWPASPEILNSQDMNTNTSEAEELVSLVRQLSGVQQQLEVIQSKIARFTGNVAGGSKPSLQAVKKEEKPRPGCLKVRDWEPEVVDLTLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ01</accession>
    <name>A0A401GQ01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0602750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615210.1">
        <property type="nucleotide sequence ID" value="XM_027759409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ01"/>
    <dbReference type="FunCoup" id="A0A401GQ01">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQ01"/>
    <dbReference type="GeneID" id="38781214"/>
    <dbReference type="InParanoid" id="A0A401GQ01"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="246"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="487"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="865"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="889"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="967" mass="107581" checksum="EF763F013835C96C" modified="2019-05-08" version="1">MASPLGKRKERDGEDTPVVTHGSTLFVSNLPYNATSTDLQTLFSDLAPVRSAFVVLAHGSGVSKGVGYVSFAVKEDAQSAYDKINAEGIVLDDRILRVQWAEYKSKDKTQKEKSEKKQPRPSVPRPHPNPASHDPLAIRTVVIGGLPASIDSKTLWKKIRKLEGAEKVEWPITSDAGVGGHSVAHALFTTPATASEAVNKLHAHVFKGSLLSVTLKKRLDSLAKTSRKPKKAATAPPNEATPSRASRLIVRNIPWDIKEQDLRAIFLPFGPIHSIDIPRVAVCAKEDVKSEGGDEKTSRIKGFAFVWMLSRKDAEKAMEGCNGMTIQAGMAERMVSDKHKKKKQKREELKRQQAPKTEDGEEGYEEEEGAAQSRAQRVIAVDWALSKDQWEMAKAKMEAEGEGDNDVEMAEASHDAGSENDGGQSGSESDGEQTGSDDEDEHLGVHQDGEEDSDDENDDGSRIDGDSDGEDEQEPAKPTLPPPESGMTLFVRNIPFEATDDELRVLFRAFGPLRYARIAMDPESGRSRGTGFVCFWNKMDADKAIAQSEILRSETVGDKAAAPKKNPFKLPSLLTPDPSASMAQNLVLHGRTLDAILAVTRDEAGKLKEAGERQREKADKRNLYLLREGIILPNTPAAESLGQTELEKRTQSYNSRRALLRSNPSLYVSRTRLSVRQLPIFASERMLKRLAVHAVRTFEKEANEGVRQKLTDDELLKPNHTEDPDADGEIKEEEHEEQNKKRGKSKGGRDTGVIQAKIVRQQDRVDPVTGKGRSKGYGFLEMAKHADALRVLRWANNNPSVGSLFEEWWKGELKDLLNAEKKKEKMDEARVKRVKEEFERSAKSKSTLIVEFSIENVQVVQRRAAQQREKQQSSGGPTKRLRRLSLPEVKTEPQADKLDERSAKKRRILDPQLSSEKMSKHKTIVKSGQKDTCVKRRHQHLSVIYTNWIAPSAGEFNRHLHVADKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ87</accession>
    <name>A0A401GQ87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0602980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615233.1">
        <property type="nucleotide sequence ID" value="XM_027759432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ87"/>
    <dbReference type="GeneID" id="38781237"/>
    <dbReference type="InParanoid" id="A0A401GQ87"/>
    <dbReference type="OrthoDB" id="3260031at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112591" checksum="E68370B8010B95DE" modified="2019-05-08" version="1">MRAQLDDDAKIRAACKYVSLDEADFWMGVMERETYKQFKTAVIALYPGAEDDHRYMQSDLTQIVRAARMRGVSSRVEEGQYYRDFTRVALFLLSRGRLSTYERDRLYLEGFEASPLHAIKNRLVIKVPDQNPDNPYTISEVHSAAQHILSGSGSASSTVAVSKLSTGTVKLEGNETDAMRFLANVLQQAMQTSGGGQAPVMQANIQAAVTQNPLPQALRACNFCLAIDHFMIILPNGQFVPRDLPGCSMAERVDAWHDMYPGNLFGDGLGPSAAPPPNVSRDGRDQPPHMVSLWEIAKEALNPKEPSSAYIEECRDDSAMSVLEANVAPKKKTVRFDDSAAGKSAKRPPGVPASQVPASILKPALDPSAAPRGGAKASLPSARNCTMQYSYKTPMEDKVNVRDIFERVQNEVHISLTHRELMALCPEIRKLEKEEITVKRVATMGSFEAADGEEVAEALLVDVSDGGGPLVVADNSLPLRAIDALVEGKESAECILDQGSQIITMRRDIWEHIGSTLQSEKTLNMEAANMGINQMLGRLANIRFGHASHSRALPKATADATSRNGFSRLEESGLIRGGSTMNRHQHASDTLKMTGHVGERSLMDGRVPHIPESASSVSSLSSSMAAFSSLSSSMNSFPSLSSFAASVSSLSSSEELFPQIVSLQIEEPRVLYTLSSSFCSIGAASGVTTPAVAPGAFQIEHKAVVHGYGYKKVDKRVKPVPGILADEFRIMRHVPHDPMKNLPSLPFYPPDFIGGSHYTEERRRDLNINSDGFLWEEEVKLFNHILYLHEQVFAWDESEKGKFSDEYFELIRIPYQQHVPWALHNIPIPPEIREQVIQVIRDKIASGVYEPSNSSYRSRWFCVLKKDGKSLHLIEDIAEVFGGCSCYASFDLFITFDQRTLHPDSRDLMTFQSPLGALRLTTIPMGYTNSVQIMHGDVTFILQDEIPHVTIPYIDDVPVKNGTTRYETSDGGYEVIPQNSGIRRFIWEHAENVKPRDSLSGDGQCDAVGKKMQHLWTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQV2</accession>
    <name>A0A401GQV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615544.1">
        <property type="nucleotide sequence ID" value="XM_027759743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQV2"/>
    <dbReference type="STRING" id="139825.A0A401GQV2"/>
    <dbReference type="GeneID" id="38781548"/>
    <dbReference type="InParanoid" id="A0A401GQV2"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118401" checksum="1F7DE433131395CC" modified="2019-05-08" version="1">MYIGKNCASQAARYINSQLAALYENAVECLDTHGCAANMDDECRSSYALAEYSDFGQSRSKKLKDRVFHAVFNQPHVDFICNHAAILCLSIRYGFYCIENVFSAHQQPVTISDVNVKFCISFDRERHILPASESRRSLNAIQLVILDFMNAQLVSATADVAIDGSILESHLARYLRFLQDAGSNIFPSLPEFDARKPNLTIDFSLFGSAFFRLGRHKIGNVSVKEINNYLASTWFKASTLDAERNIDSDWRATSLADLNSVRALPAISNVHFQLSFDPPRLNLICSREAVVTFRLSDVKFFDTPSLEGPPKRQYGACDIVVLFDIYHEIEGHIVRCKLDINSARIVNDACKLPYVDDGDETAIEYWTGLLKFFVPGYVEILKSANYHVVYYDDERVHASAAGEGRSPLPSSPATQVSFAWKQALTDTDLHGFDQVIVVSQSSANAHLYDLYSRSLKDPDLEWLSDWGTDDFHARVQPMTCCLLSNNKAIVWVDLAVGNLKMPDQEYEFEDLRLAFELTLKMFTHDNLFLSRNGLRIFENSLAYKDHCLDGAYEFRHICLDFTSCKFLHEYSRFESVFEHCDRNTIDVARAIINNIQKQYFSVFTTEGLGVIHTLPIWAGDALQDRPAHVLTDVAFYVHSESTVDRQNWMEVSEFLAPVIVVLGMCNFRRLPFRYLDLPPSWHALANEQGSHGILAIDRTVFLEDWLLKSLAYVNRATTLIPEFSRPKDGSWEPEMIPWATHCFKKDHPCRWQLRSEQDGFLRFAWKNLDGWNYGHESGPTDSMNGSYAISCGTRNYLEIPSLGPQKELNIKIRGEIELRLSCNSSRTHWSVKSSAKWDIVLVIVTESSGLHFELQTRSAMFDFARNEIEGDTTAVADAKALLKECLQDSLDFTTMMDQLWPLEGIWQSCYPGSLGFTLAHPGFSTQGDVLLKLRPFGQLSSADHTAPGSRQALTICSRRRSQSSCTVSPRSSPSRHLPSLPSPGCPPSLSPPASRLFGALSPPSQRFVRPSARDVEQARAMFAYAVAITNGASTDSNNLSEPGHIDVSESHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQX5</accession>
    <name>A0A401GQX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615539.1">
        <property type="nucleotide sequence ID" value="XM_027759738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQX5"/>
    <dbReference type="GeneID" id="38781543"/>
    <dbReference type="InParanoid" id="A0A401GQX5"/>
    <dbReference type="OrthoDB" id="3070390at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="379" mass="41828" checksum="6224873C4A385EA1" modified="2019-05-08" version="1">MSQDSAEAGHVQIWFQYKGDRASALQRTPRKEQTDEKVPLLETLAIEDLRILDLTLSGVSYSTVVNWGTGQLRLINKSPIPLTQVRQLQVAVGRVNARENEKSARSIARIQCKIDNGTRQALETQLGKYNNDSICTGVSRSGAPILSRMETRAKAAALTRTAGLQASSAAVADLPPRPSHALKAGVGMSQMVYPAQRPPSAAPQTAYTLVRPRVDASVQTTDYFESQIAVLRAHLTREVERSKNLETTLLSERQEHQDVRSALEAERVQREAAETELRAAEAALTESRAHCENLEKAIDLERVRCETVDSACVDERGRREQAEAAVEAERRWRQQAEAMLEEVRRERAAPFVVPAIMDAFVKLVQLSDAVANAPEDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR50</accession>
    <name>A0A401GR50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0606620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615596.1">
        <property type="nucleotide sequence ID" value="XM_027759795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR50"/>
    <dbReference type="GeneID" id="38781600"/>
    <dbReference type="InParanoid" id="A0A401GR50"/>
    <dbReference type="OrthoDB" id="2694124at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="263" mass="30635" checksum="B44B3DD3A611DC2C" modified="2019-05-08" version="1">MFPKATVTLEDHIATLRDISDEIRLQGRTAVESLWYEYWDTALNFFGLSLARRSQRVTISPQRGISRDALRRAVELPADYAEWSTEVQLGDLEILTEDLSIQDDEETRKPALLEHFVVLVTKGRSPQSILLIVEVKAFDTAANISDLELAKDEVEDAREQIITQAKFAFDAFREQDRLFIMRAPCDYWQLVEFRREDLVTLPVHKLRDKDVESYAQPTMKDKLFYNSGVYPVLNDDRTDYHPQWKAKMKRILNRLGVEYDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR86</accession>
    <name>A0A401GR86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607050</name>
        <name evidence="2" type="ORF">SCP_0607170</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615638.1">
        <property type="nucleotide sequence ID" value="XM_027759837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR86"/>
    <dbReference type="GeneID" id="38781642"/>
    <dbReference type="InParanoid" id="A0A401GR86"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7394" checksum="4D478D4E3CB38F79" modified="2019-05-08" version="1">MNLRLCMGHGSDAVGGTNPLAVEVRLQSKHHAKLVEDVIHQAFAQLQLLGRQGLEPVGDSGHESDLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRE1</accession>
    <name>A0A401GRE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615705.1">
        <property type="nucleotide sequence ID" value="XM_027759904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRE1"/>
    <dbReference type="GeneID" id="38781709"/>
    <dbReference type="InParanoid" id="A0A401GRE1"/>
    <dbReference type="OrthoDB" id="2776971at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="173" mass="19211" checksum="0AFE106965E784C0" modified="2019-05-08" version="1">MLYYGVPVIQNHMHLLVPDDQLETAYKVLLAAGYKDSPLPLIPMVSSRDPNTHWEELGCPAYRMVLLRDGKRSLIILIQNYSAAASTFDDANPSSFEQCAGLAIPPLPLLGQSFLRTYFTYFKSSGRKSRVSSILQVWCASVKLSGYAPLGVDAMRGVPGISDAMTLYWERGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRK7</accession>
    <name>A0A401GRK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0700610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615794.1">
        <property type="nucleotide sequence ID" value="XM_027759993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRK7"/>
    <dbReference type="STRING" id="139825.A0A401GRK7"/>
    <dbReference type="GeneID" id="38781798"/>
    <dbReference type="InParanoid" id="A0A401GRK7"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="192" mass="21513" checksum="19F3850D04EF893D" modified="2019-05-08" version="1">MNSDEMDDDNIWLDDPKALEDTEWSKLSSDFTNAGYREGITAGKESALQQGFDEGFAEVGAPLGRELGSLRGLASALLAFLTSNSQERPDDLTELQEMVSQLGSVRFSDIVPLDLEAERHAREHLDMDGEDEGELDLELNEELKDKRDIERLEDMMAQVSAGAARPTREDVQRLKEQLRNLCDELGIPVQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS70</accession>
    <name>A0A401GS70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorismate mutase</fullName>
            <ecNumber evidence="3">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0701960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13898"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615923.1">
        <property type="nucleotide sequence ID" value="XM_027760122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS70"/>
    <dbReference type="FunCoup" id="A0A401GS70">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS70"/>
    <dbReference type="GeneID" id="38781927"/>
    <dbReference type="InParanoid" id="A0A401GS70"/>
    <dbReference type="OrthoDB" id="191918at2759"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.590.10">
        <property type="entry name" value="Chorismate mutase, AroQ class superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008238">
        <property type="entry name" value="Chorismate_mutase_AroQ_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037039">
        <property type="entry name" value="CM_AroQ_sf_eucaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01802">
        <property type="entry name" value="CM_pl-yst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21145:SF12">
        <property type="entry name" value="CHORISMATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="Chorismate mutase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51169">
        <property type="entry name" value="CHORISMATE_MUT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="13">
        <location>
            <begin position="165"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE85010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="332" mass="37733" checksum="A3A52DB4A06AC66B" modified="2019-05-08" version="1">MSMILQNYTLEADPLSLDRIRSILTRLEETVIFSLIERAQFAHNPKIYRRGEFQELLEIGFKGSWLDWFLKETETFHAKARRFTSPDEYPFTDPSELPAPILKTIPYPDILYPNKINANPSILSFYTRSIVPRITRQATVALAAAKRAKGIVGDEEFEDDGNYGSAALIDLEVLQAISKRVHYGKFVSESKFRDDPVAFIPHILKPNRAALDALITKPEVEKKLLQRLRKKATVFAQTFAPDGEPLSDESTRKIDIDGVVELYEHYIIPLTKEIEVDYLLVRLQGMSQEQIDVLMTTDAKGSTVSIKTEPDDPNREAQTVEEIASTARDTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSZ4</accession>
    <name>A0A401GSZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0700340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615767.1">
        <property type="nucleotide sequence ID" value="XM_027759966.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSZ4"/>
    <dbReference type="GeneID" id="38781771"/>
    <dbReference type="InParanoid" id="A0A401GSZ4"/>
    <dbReference type="OrthoDB" id="2591260at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1580"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="510"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1593"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1616"/>
            <end position="1632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1632" mass="179701" checksum="12BFBEC0987A1955" modified="2019-05-08" version="1">MGRDARILVESTVTNASDAREEASSSSMAAHMGLPTPPNTAHREEKENRWALFPTASRVVWSDSIQYHTISVSSRSSTLFESSASRLLPRRSILKKTVHVLPPIQEEFQKEATPEPSDPLVNLHYLDGPVSRILAADASMTDLIKAYTVLTARLRTCVPGNTDADASWPLFQPLRYHREAFVDALVRDLERALVDPTAPSVQPKDEPVFSLPSPKQSPKKKRSMSGEEAKDARDLCMTCQAVMKLLAVVFTLPAVYQIFTDAQLGFVLTQVLAIPLANELPTQNARKTNALAIWLLLTQRLPPEILAPAKDRIAYALRRGIEGELGKEGKKGSASDGLRAIHDLSTTYPALFVPAFTELLPSVLANLLAPTLALRIQACHALGGFAYAMASLPPSPVHTRISELVAAYLTRPTTTSDKLHSPTQDLPIIRTLRTTLNAPEAAHAAQGPVWAWCVLAAFIVLLGPTLFVREKLTTTMTALLSLGMRHPKSTVRAVGCMAWHGMTWAYFRPLAELEGQTEEDEEDAPESEEDSEMEAFEIEESEMEELEETGTEKVVGRKQYYKRLDSGWKIVQDKVELGTGIAIIGALLGREPGVTTDELSLKRTISVLRSMMKKGGRTFEDALEITLQLVDQEPQKEWDMRKLLAPGLFSANPGLLTAQWNSLPQVVRPLLEDCPQPADVRSLTRDELTIEWVFNGLLQVWRAGLSALRLYWPCEIPAEIGEIWTGLLSANVAALQDAGDEEATAGFAGCIVNVLVDILRDRTLDISADSDDGLTELIPTSDSRPVQRRVSLLTRSRWNLVLKLVVIRELWTIARTIFPRSALSGPAEKLLMYLDRHESDLVDDMDLPDDIRKQWAYLCAEVAFVCDVYELKQFWGRRSYGTRKQERNWSDDVRCLVWRKFVNKLSECSGTWEAAVVLLGVPFVEANSWEMSTEDLETWNTLLRTTMDNALDYGVDSVSVVDLVSSLISSNHAPTLASSTRVADLLLSHLEIGEARQIPFDMMEFINDTLISTYPPEPRNKVFCMWLLRSLTRVIDACPVELSLNLLETLQEGLVIWIADDYEVFTPDEYSMDILPMYQTLLLGMQSLPSSLSTLESIGPLLESAFSVREDNLSSVSQTFDEFWQASYAQLPRPRQGWPEKIENCLAVISGDADLSIMDASLECIPPSSFLLTDAAPGHNIEEVDDTEKYLSPLEDVIVEPLSALLPAFCGSLIPAVAGRSDAVSPPSTPKSSQRPLPLTIPTRPQKPSGQKDLVSICFKSSSPVLPSPTRSLLTPRRSPHSGSRHVSSSVRRHGLHDKENATPLRAVPSVAERIAMVSPCDSSTLGKRHLTDEVQEEKAPKRRKLEVASVGPILGEITVNSVTEDSDIPQDSSVRPNTLFETSQVQNAGCLDQPLYKLSGAPSGLATKASELGITAIPSSYSKPSKKRKGVFLDAVEVPTFSEVLRLERQRPCREPRSCSQLSRTAALANESRGLLRRTRSATKLLGDETTFLTLDCTPCKKRKSSTLRIEPIPSTSRLSPLVQVVLDGPIVGSDDSIMLASPTKPNDLSSDDDPHVGQVTPLGLVSPAIRRVRGDEFDLSSDDSVMPASPSRDRVARRIARLPERSSVKLTPMGGLSSATSGSSLPGYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT18</accession>
    <name>A0A401GT18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616270.1">
        <property type="nucleotide sequence ID" value="XM_027760469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT18"/>
    <dbReference type="GeneID" id="38782274"/>
    <dbReference type="InParanoid" id="A0A401GT18"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="116" mass="13538" checksum="40E818569401CC09" modified="2019-05-08" version="1">MMPREVDCEWESAARIMDEQQFLTLREFRLDVRGKDLAEEEKRRISDCFDALRRRGVKVMLSFGYPWFNFVPLEPYHSDSLTVSARQSKTPELQVEDVQLSGVPLTSNDDEHQSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTA4</accession>
    <name>A0A401GTA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0701460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615877.1">
        <property type="nucleotide sequence ID" value="XM_027760076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTA4"/>
    <dbReference type="STRING" id="139825.A0A401GTA4"/>
    <dbReference type="GeneID" id="38781881"/>
    <dbReference type="InParanoid" id="A0A401GTA4"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="50985" checksum="1C6D0C3326AD8D10" modified="2019-05-08" version="1">MSSGHSLPALVNEHPGGRRSALGPTRYAHEQGVTRITNTEADATADSGPDSSPGLGLFDHHRAGNIPRSLPTGVSTTTSVLVYHPQPRWANLPSDDVSGFQAALAGDRYESEVASDTSSNFPLPSVDSRMNNTGSAPNREPKTRHEKSRIQLAPDQPLTTQGKPRTRVYSDDAVGLGRSVVMEQNHFAIIVAVARMGIVNVHTTPCPNGGVQTKLLEVAIVVERSTSLDESKQDVEHELTIPGIQLLFPVPHTLRGASSSSSGSFHEQPCDGRQPTRQSKHDFAPNLQEYVEAAAHSSHASQTTPPSNSRSEEKDARSSETGIGAEPSLQHSRKTWWDALINLYSLPSDHLHGHPTPNSPTLRDATVQHITGDLRFLFRVSTHWLSFLHAPRFFARFQDGRSRAQLQPSLLLGALAVAALLRCSEPGQASQRKERAIRLRDEAQSALEASLSARWVDQSLVQASCVGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTS7</accession>
    <name>A0A401GTS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616502.1">
        <property type="nucleotide sequence ID" value="XM_027760701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTS7"/>
    <dbReference type="STRING" id="139825.A0A401GTS7"/>
    <dbReference type="GeneID" id="38782506"/>
    <dbReference type="InParanoid" id="A0A401GTS7"/>
    <dbReference type="OrthoDB" id="2659442at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="300" mass="34694" checksum="D9D5CF5181F14AFE" modified="2019-05-08" version="1">MEHSKEDGTLPPIAPQLLVDMHISRAEEAFMEIDEQVTEEWRLENEIPNTDVIEETREGLAQKRNRAPSTVVKQPRRKAARRSSARGPPLHFFGLRSIISRLVAPCPWYHDTSETSHRPHRRILCINRLAGPHIVHPVLEELALAPFGASLDHLELDMRCHNAFDPQQLCLAHSTELHTLCLCSQSYSLSEGNLEQTLPAILSQISPKSRLRRLELTVKVTDIDWKRVDEILAQDHFIQLEMVTLRYWWSAVTREDIDWWERELSERMSRSLSRLHLRGAVVEMLPIHGEVNMLVNRDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTT5</accession>
    <name>A0A401GTT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0703300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616057.1">
        <property type="nucleotide sequence ID" value="XM_027760256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTT5"/>
    <dbReference type="FunCoup" id="A0A401GTT5">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTT5"/>
    <dbReference type="GeneID" id="38782061"/>
    <dbReference type="InParanoid" id="A0A401GTT5"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE85144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="163" mass="16588" checksum="E3D13E50530A28E5" modified="2019-05-08" version="1">MSDLCPVYAPFFGAMGCTSAIVFTCIGASYGTAKSGVGISAMSILRPDLMMKCVIPVIMAGIIAIYGLVVSVLISAELTMHMSLFQGFVQLGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALIMNSKASDMAGVCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTU0</accession>
    <name>A0A401GTU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial metalloendopeptidase OMA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0801620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616555.1">
        <property type="nucleotide sequence ID" value="XM_027760754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTU0"/>
    <dbReference type="FunCoup" id="A0A401GTU0">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTU0"/>
    <dbReference type="GeneID" id="38782559"/>
    <dbReference type="InParanoid" id="A0A401GTU0"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="178"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="378" mass="42343" checksum="5BA28EB1EDD4D50F" modified="2019-05-08" version="1">MLPGVSRALFSSSVRLRFPRCISRRPLAVRQLSSSSPRLARYARFDPEHPLDMRRWDTGMKVVAGVIVGGGVYYVIHLEQVPETGRWRFMDINPKFEAKLAETAREELLAEFKGKTLPPNHPLTRHVRRVVTRILESSNLGTLSSPEHRIVSPEQVLEDLWEPQLRSESETPPGAGGRVWNLLVVNDDKIVNAMASYGSIVVFTGILPVARDEAGLAAILGHEIGHVVARHASERYSEAKVFIFLAYLLELTGLDFGFARMLTTLLYSLPNSRTQEFEADKIGLTLSSKACYDPRSAPEMFARLGKLDEGYLNISFLNTHPTSDKRIKQLEDMLPEAYALQAATPECGDSLRDSLGAFRDTFARGFNKDNESASWRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU39</accession>
    <name>A0A401GU39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616639.1">
        <property type="nucleotide sequence ID" value="XM_027760838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU39"/>
    <dbReference type="GeneID" id="38782643"/>
    <dbReference type="InParanoid" id="A0A401GU39"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="10825" checksum="031E36ED75ED6DF1" modified="2019-05-08" version="1">MSRFIPYLARKTNIVANDTQTESDSDGESDTELHGRRADKKGKGKGKGKGRSKGKAKGKGKGSASNKRSVQQLAGSDVDMFAELPECQKCNALIKGLMQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU40</accession>
    <name>A0A401GU40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein mago nashi homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0802730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616664.1">
        <property type="nucleotide sequence ID" value="XM_027760863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU40"/>
    <dbReference type="FunCoup" id="A0A401GU40">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GU40"/>
    <dbReference type="GeneID" id="38782668"/>
    <dbReference type="InParanoid" id="A0A401GU40"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="149" mass="17488" checksum="A26FC19487EE765C" modified="2019-05-08" version="1">MTSYDNDPFYLRYYTGHSGKHGHEFLEFEYSHGRLRYANNSNYRNDSLIRKEMWVGPLVVKELKRIVESSEITKEDDTNWPKKNIVGKQELEIRVGNDHIAFETAKIGSLVDIQDSDDPEGLRVFYYLVQDLKCLIFSLISLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU51</accession>
    <name>A0A401GU51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616626.1">
        <property type="nucleotide sequence ID" value="XM_027760825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU51"/>
    <dbReference type="STRING" id="139825.A0A401GU51"/>
    <dbReference type="GeneID" id="38782630"/>
    <dbReference type="InParanoid" id="A0A401GU51"/>
    <dbReference type="OrthoDB" id="2804753at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="852" mass="93627" checksum="9D5C1A375EFB0947" modified="2019-05-08" version="1">MDMATGSSSRPILPHTRTLESTSDEDLASFLPALFATSKARVLAEMARESPRASGSTENASGLDATAVIVDTGGSNNNICALGAKIDDVLNDPDFQNQMVQSFRRQMRLQELQVQEADADTRTEWHISSFKDGLPRERTPGQSESPLPRGVFDGTKEGDAGTGGAIAGTRSDIDMDPNSQPAHEMPTAVQQQPRSPAQALRAFLTGSLPQHDIVPVKHVPDDPPFGPICVPEWDGFKDWWVHVDINNPPATLADYYKALAETEAQALAVFGDPLELYKRTLEAHPPGYEVYNLHKAVESLSIPGPALLPPSQHFPAIIGMPPPPPDDPTEVLGQDPWSMVEILLLLDVIAHYSPAEAGWEKISQVYNNVLLGTLRKWIADRMRDSKKDMDTRRSLAQHMCVDRAKEKYALMHGRAVKPQVESKDPRAPLQNKQHYALPTRLLACDLPSRRDSERSLRGLDVSDPIALVQIDSRRRAPYTFEGWVEQEAETMPPPSESFVFGPVDSAASAAIPSPLMPPEAPPSQLIEQPDKPVEVLPEPRPEYRIRPPPLSMPVAQASLLTSTLAAFRVAKKAQLTEPDQYERLVDDALRQATDLYAELNPAYPIRTAWECWHRWCVPLGKMEVSAGSIVNANNKSKGNFKKPKKGKKTKSAVPSIHPVLGNLVNFAAPVPIPGTFPDEPGVVHHFVKHDPRPGLQTFAAAARAHQQNSNGTFEWWLRCLRGVSSSPGCGPIRPEGRRNKSRYPNVPVGTLGSNVRPGIFAWFQCALVNRTMLRLVTDAGRSRRASTREDGNSSEDAPSDDDSSDNSDATEGESEKMCGRGLDWLGEGAKVLPAHLRDLPIPPRPKYLGRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU71</accession>
    <name>A0A401GU71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3 8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0803070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3 8"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616698.1">
        <property type="nucleotide sequence ID" value="XM_027760897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU71"/>
    <dbReference type="STRING" id="139825.A0A401GU71"/>
    <dbReference type="GeneID" id="38782702"/>
    <dbReference type="InParanoid" id="A0A401GU71"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="11">
        <location>
            <begin position="21"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE85785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="463" mass="51933" checksum="4C45BCB1395523E8" modified="2019-05-08" version="1">MEIMMPGTSSLSVSHDQTGSPFSVIESDPGVFTSLIRKLGVQGLEVIEIYGIEPWDTDHLEPNGLIFCYLCTDDNDSQEDAGSDNELEDRDAQRVWFANQLSEDACASQAILNVLLNCPDIDIGEQLRDFHAFTEKMSPVMRGLAIANSPFIRNAQNSLARPADIRASLHAVAAATIETQNSKQKPQDILKLPPAKKRKASGSTSKSKQSTADGTDTKQESYHFIGYAHVDDKVWELDGLRKSGPLEVGEVDGSARSARRSWMDIVRPALRMKMEKYLRSAGEGEHIRFNLLAIVEDRYQKASDGLEMLKRERTALERRLNETFPDGWADKVDPVLLASSKEAFSTSVRPSSDGTVFSRGFGSHKMEKELAILEMPSRKLPGVWDECVRNAMSAKIAVEDEIEKSRNMHTEHIGRTFDYEPFIREFVTCLHNEALLEKALSQKAGDEDTNERPRTRRKARMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU92</accession>
    <name>A0A401GU92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0803270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616718.1">
        <property type="nucleotide sequence ID" value="XM_027760917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU92"/>
    <dbReference type="STRING" id="139825.A0A401GU92"/>
    <dbReference type="GeneID" id="38782722"/>
    <dbReference type="InParanoid" id="A0A401GU92"/>
    <dbReference type="OrthoDB" id="2965932at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="198" mass="21380" checksum="B7B393C510B85D15" modified="2019-05-08" version="1">MPHPGGEDISPLSKCRPQVANSGCKNTSLYLAGTPQCKTNLVPAVDDYGGLAKVVPDTQDLPELQSDDISPSKPPLHDGIIGRHSILHTSSIMVLLLLLGLASALGHHAFNAHLVGHAVDSDLSFGGWFNVPSQTLVFRVATAFVFLTKTFFTSAVSMAFTQRLWVTVSRKYLRLSGLDALWAVLKYVVIGFCDFSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUH5</accession>
    <name>A0A401GUH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616800.1">
        <property type="nucleotide sequence ID" value="XM_027760999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUH5"/>
    <dbReference type="GeneID" id="38782804"/>
    <dbReference type="InParanoid" id="A0A401GUH5"/>
    <dbReference type="OrthoDB" id="3269515at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="19670" checksum="91271770E9A51456" modified="2019-05-08" version="1">MLGQGSNNGDSAAPRNKLHGVSHPTVRTEMVALHSVPSSPLDRSLLFAPERYPRQRNLRSPKSSLPPRPATAPPTTSIFASTVSSPRKTLTPFSHSFAHQRPTLSDRESSGNILPPPPPLFRPTTFWRNHPKSGVTGASYSPSTYLIRRSTFIAAGLPFDVPVADLSALCVEARVGTVFLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVM7</accession>
    <name>A0A401GVM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0901600</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617194.1">
        <property type="nucleotide sequence ID" value="XM_027761393.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GVM7">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVM7"/>
    <dbReference type="GeneID" id="38783198"/>
    <dbReference type="InParanoid" id="A0A401GVM7"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="38"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="188"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="15">
        <location>
            <begin position="671"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="1469"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="1811"/>
            <end position="2125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE86281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2230" mass="247173" checksum="4E8847083C4CB949" modified="2019-05-08" version="1">MSAYDHAKVAQFIGGNTLERAPSGNVSDFVKSHGGHTVITKVLIANNGIAAVKEIRSIRQWSYETFGTERAVEFTVLATPEDLKVNAEYIRMADRYVEVPGGTNNNNYANVDLIVDVAERAGVHAVWAGWGHASENPRLPESLAANKIVFIGPPGSAMRSLGDKISSTIVAQSADVPTMAWSGSGITKTTLSEQGFVTVPDDAYQQACVTTVEDGKAKAEQIGYPVMIKASEGGGGKGIRMVAAPEGFKNAFTAVAGEIPGSPIFIMKLAGQARHLEVQLLADQYGNAISLFGRDCSVQRRHQKIIEEAPVTIAKHDTFEEMERAAVRLAKLVGYVSAGTVEYLYSHAEDVFHFLELNPRLQVEHPTTEMVSGVNLPAAQLQVAMGIPLHRIRHIRQLYGVAPNGTSEIDFDMKNPDSSQVQRKPQPKGHVVAVRITAENPDAGFKPSSGSLQELNFRSSTNVWGYFSVGSTGGLHEFADSQFGHIFAYGEDRGESRKNMVVALKELSIRGDFRTTVEYLIKLLELQAFEENTITTGWLDSLISGKLTAERPDTSLAVICGAVTKAHMASEASWSEYKRILDKGQVPSRDILKTVFGIDFIYDNVRYSFTATPSSLTTWTLYLNGGRTLVGARPLADGGLLVSLDGKSHSIYWREDVGALRLMVDSKTCLIEQENDPTQLRSPSPGKLVRFLVDSGDHIGAGEPYAEIEVMKMYMPLVASEDGIVQFVKQPGISLEPGDILGILTLDDPARVRHAKPFEGLLPALGTPSVIGNKPHQRLRYYLNILNDILDGFDNQAIMAATFKDFVAVLENPELPFSEVLAILSSLSGRMPTKLEEAVRAAIETAHAKGDAAEFPGVRIKRLLEHFMEDNIRAQDRPMFRTQLGPLFDIVDRYQGGLKAHETSMVAGLLARYEEAEKLFGGSIEARVLTLREQHKDDLDKVVSLVLSHIMAHRKGRLIMMILDHIKGHSSSVSNPESKLHQVLQGLAALEARSSAQVALKAREVLISCQMPSYDDRKVQMEGILNASVTNSFYGEQGSGIKTPSADVLRELIDSRHTVYDVLPTFFNYADPWVTLAAFEVYVRRAYKAYTLLSVDYEEGDGLDDGDGPNVVTWRFNLPQSHSPPTTPHLEQSRRQASVSDLTYMIARHQKQPLRHGAIASFPNFAALSRGFDKVAGALPLFDIHEYRQRYGDNDQSPNVLNMALRIFNPTDDMSEDTWYQNIHALVNERKDILARRGIRRASVLLCKPGLYPLYFTFRDVGSSWEEEQAIRHIEPALAFQLELTRLSNYNLTPCFTESKQIHIYHAVARENQLDSRFFIRALVRPGRIKGDINTAQYLISETDRLVTSILDALVVVSAQYKNADMNHIFMNFIYNLPVTYEDVLTAISGFIERHGKRLWRLHVTASEIRMVLEDSEGNVTPIRCIIENVSGFIVNYHGYQEITTDKGITILKSIGEKGPLHLQPVHQPYPTKESLQPKRYQAHLIGTTYAYDFPDLFSKALSNVWVKARDRNPSLSLPKRVLEPKELVLDENDQLQEVDRAPGNNTCGMVGWVFTMRTPEYQSGRRVVVIANDITYKIGSFGPQEDQFFYLASQYAREHGLPRIYLSANSGARIGLGEEAMNMFSCAWNDPNHPEKGFDYLYLTHESFLKLQEKAAGAVRTVEIEVDGEVRHKITDIIGLQDGLGVECLKGSGLIAGETSRAYDDIFTITLVTARSVGIGAYLVRLGERAVQVEGQPIILTGAPALNKVLGREVYTSNLQLGGTQIMYKNGVSHLTASSDLEGATHILEWLSYVPEVKGGPLPILDSVDSWDRDIAYTPPKGPYDPRWFIGGKTDESTSEWMSGFFDKGSFQETLSGWAQTVVVGRARLGGIPMGVIAVETRTIERVTPADPANPTSFEQRIMEAGQVWYPNSAYKTAQAIFDFNREGLPLIVFANWRGFSGGQQDMYDEILKQGSKIVDGLSSYKQPVFVYIVPNGELRGGAWVVLDPSINSEQMEMYADVDARAGVLEPEGIVEIKMRRDKILKLMERMDSTYASLKKDSADSTKEEEERTAALDAMSDRESLLQPTYKQIALLYADLHDRTGRMEAKGCATPMVWKDARRRFYWAVRAKIARSAAMAQLAEASPDSSSEYRSRLLESLAGISATTDRRVVAETLEALDLTATIAQLKADHLMRRMLALAHIDRKATLDALVRLVDNLADDEKTSLVNVLQSSSRSPGPPSYSNVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWA7</accession>
    <name>A0A401GWA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sorting nexin-41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0903840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617418.1">
        <property type="nucleotide sequence ID" value="XM_027761617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWA7"/>
    <dbReference type="FunCoup" id="A0A401GWA7">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWA7"/>
    <dbReference type="GeneID" id="38783422"/>
    <dbReference type="InParanoid" id="A0A401GWA7"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="84"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="384"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE86505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="586" mass="65640" checksum="1E49FC0549CB87AB" modified="2019-05-08" version="1">MEPFEDENPFEIEPDRIHSDSSSTSKVTLSEPSSPSPAPARVLASPPTSPSPEKRPTFPSSGSHRQPQAFKSDFCCIRDQWLHSGEDVEVLITDAQKTTLNSSTPYITYVIQAGTAIAYHRYSEFESLRSNLVKLYPTLIIPPIPSKQTIGDYAVKQAKAKEDAAMIARRKRMLQTFLNRIARHPILSNEHVFHRFLDGEVSWAEVLHSPPLSLLPKNILKAPSHNPTDQNATAAYAALPNPSAAHPLRRPDQRFIDSESFTNKFAAHLSGPMEKVTRRTMKRWSESAQDHAELGATLNGFSLNETGQLSSAIEKTGQAIDATYMSTTTLLQEFEQDWAEPLHEYSQFASIIKKLLVYRHQKHVQYEMTQDTLEAKREQLEDLEKSEREARRLEEALSHGRASRLGASQIRTVEGDTVNEAANEEGQPRSEEISSSYLPPHPGPNPVRRRAPGMGFLNALTYTLSGMMDVDPETARRNSITKTRETISQLEDALHLSAQDLKYSSSTIQADLDRFQRQKVADLREMTISMARSHRDWCKKNLAAWEEAKAEIAKIPEHPNRPTDDVVNGSGATTGRRDSTATINGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWF2</accession>
    <name>A0A401GWF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell differentiation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0903920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617426.1">
        <property type="nucleotide sequence ID" value="XM_027761625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWF2"/>
    <dbReference type="STRING" id="139825.A0A401GWF2"/>
    <dbReference type="GeneID" id="38783430"/>
    <dbReference type="InParanoid" id="A0A401GWF2"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="702"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="563"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="805" mass="92026" checksum="3FEC82540369E46A" modified="2019-05-08" version="1">MSPKTEEYWSDSDEEAGSDVETAVQLGIPDGLVASSADLLDVNVSRIGGHPTFLTSPEPPFASALCKNCSKPMELLVEVWCPLEGSPNDRVLYIWGCASGACQRKEGSVRAWRGLRHNQKYADKLSKKLAKQRLKEEEAQIAEEAARQKTLKANPFSLKTVGSSNPFALGAQVFGNAPLEPIKSDDHQVLDSERQDDDENGPQSNEDDDDDELVERLAAATLSNSEWASAPAYAPLYLSTVSEYLPPAPKSKLSSGANIDEDDEERRKKDTGWALEGYENSMEVDHAFERFTKRISYEGEQCLRYELGGTPLPFSSDEVFNSLFPAPSSPYISVTNREFAVVPALKRTYNPSALPHCPHCKSKRVFECQLMPNLISVLKRGNDAESGKKQTDEERRQEVLRELKGGHRKLRSKLAVKFKFFPKHTRTAPRRITIPEEDEGHLDVPPPPPPKDRRSWEDMYCAFELSEATEFARSPSSDSSRASESAEVGGEYLRRIFLARRQTQVQSNLSPQRRNASLPPPPGTHPPPSMQSVSPRIPPSRIPQRSPRRQRAASTPDEVELHRREAIRIREREEQQARMEEAQRQARLKQEKEEILRRYMEEERQRKAALEEELRRAADQRRKKEAIEREADELKRMIATERRRVEREKRIQETLKLQAWRKEQEKRAKETTGKREELRRRLFQERRDLASRLKDAAGAQSKVFLSGWVTVQAEESAAWKRRYYQLNDRALLLFKNPEETTQSSDTVRLSDIQHIKEWHEGFEELEGIPHSFAVEFHDGRSWSLFADSSLDKEYLLALLSQQMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX08</accession>
    <name>A0A401GX08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1000080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617679.1">
        <property type="nucleotide sequence ID" value="XM_027761878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX08"/>
    <dbReference type="GeneID" id="38783683"/>
    <dbReference type="InParanoid" id="A0A401GX08"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="9243" checksum="13B02FEBE9E020FB" modified="2019-05-08" version="1">MVIMEFVEGRDAHHQFKGRELRPGLMRDVKLAVDELHRLGLVFGDLRRANIMVVTKDLYAVKVRGLGRGRRWIQVWARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXN6</accession>
    <name>A0A401GXN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0904330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617467.1">
        <property type="nucleotide sequence ID" value="XM_027761666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXN6"/>
    <dbReference type="FunCoup" id="A0A401GXN6">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXN6"/>
    <dbReference type="GeneID" id="38783471"/>
    <dbReference type="InParanoid" id="A0A401GXN6"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8347" checksum="6F7BDFC0DD4ACA9C" modified="2019-05-08" version="1">MSNTRESDRISAAQQTLDTLHDISQLLNTQLDKETLATCVGMIESGVNPEALAAVIQELRRESQALNVQPSTNSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY11</accession>
    <name>A0A401GY11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1003290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617995.1">
        <property type="nucleotide sequence ID" value="XM_027762194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY11"/>
    <dbReference type="STRING" id="139825.A0A401GY11"/>
    <dbReference type="GeneID" id="38783999"/>
    <dbReference type="InParanoid" id="A0A401GY11"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="4">
        <location>
            <begin position="72"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="354" mass="36842" checksum="EFA2658E43E91E30" modified="2019-05-08" version="1">MCYAAASPRNDYASSLENYQADHVLLRMQIYDHHVERATRFQEQFRPEMHGATLFTTTLALGCITAGCAQNIILTNDDGWATAQVRAQFSALTSTGFDVILSAPAVNMSGTGSTSATPTPLGEPCEFDTCPTGSPAEGFNASDPRLNYVNAFPVDAARYGIQTLAPQFFGGPPELVVSGPNIGSNLGLAVFFSGTLGAACEAAKEGIPSIAFSGTSGSQVSYTTLTSTPNATSTLAAETYSALTATFVQALTSSGISPLLPGGITLNVNYPSVDACPSPADYQWVLSRVFLNILATDVETCGSTTLPLESNVVAAGCFASVSVVDASTKMDANLTMQAAVLQRLANLPLSCLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYL6</accession>
    <name>A0A401GYL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1004970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618163.1">
        <property type="nucleotide sequence ID" value="XM_027762362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYL6"/>
    <dbReference type="STRING" id="139825.A0A401GYL6"/>
    <dbReference type="GeneID" id="38784167"/>
    <dbReference type="InParanoid" id="A0A401GYL6"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="520" mass="58296" checksum="B054690125763461" modified="2019-05-08" version="1">MADVTTKSPIPTLASAPFDKANADVILRSADNVDFRVHKIVLALASPLFEDMFTLPQAACEDVKHDGATIPVIPCPENNRTLDHLLRLCYPVDDPVHVMPMEIRDVLSAAAKYQMQEAVSLMRTALLRLASIDPMAVYAVACDLSLDLVAERAARGFRSDPLDDYVPEMDHISAGAYYRLLQYRMASSPPAIFDFFGHDQNGPSSPGGLDRAAATAVPSPQTVLPIFSSKGEGDFILRSRDGTDFYVLERLLSLASSIPLSSWPREQKDCSDQFPPIIFLAEHTVVLSRLLQLIYPMTEPLVEDMAEVVALLEAAKKYQVQKVEEFARRKLMEKVGVHPLRVYLVAARFKWKREAKEAARLAVYQTCDVYVPEMEMASAQAYRRFLEYREKCRRVVSECVSEYVQPEKSQSPPSPFGDLAASLTSLLATVSQRGSEKSLFWNEKGYGDELWPKIFTAIQPTSASTETQNRLHHIVYSTPRWRKTQNTTPPTQLSGFLTDVDKLEDSIRDAITRIEFKLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYU7</accession>
    <name>A0A401GYU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MutL protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1100050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618243.1">
        <property type="nucleotide sequence ID" value="XM_027762442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYU7"/>
    <dbReference type="FunCoup" id="A0A401GYU7">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYU7"/>
    <dbReference type="GeneID" id="38784247"/>
    <dbReference type="InParanoid" id="A0A401GYU7"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="233"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="739" mass="82010" checksum="547B1BD96978D198" modified="2019-05-08" version="1">MDAQRRSPSPHSPGPLPIRRLQESVINRIAAGEIIHRPASALKELIENSLDAGSTSIRITVKDGGMKLLQIQDNGCGIRKDDLPLLAERFTTSKLSSFADLSHLTTYGFRGEALASISYVSHLSVITKTKADPCAWKAHYADGSLTPARAGTTLDPKPCAGNDGTAITVEDLFHNTPTRLSALRSSSEEYARILDVVTKYAVHNPHVSFTCKKAGSPTPEVSTPSGSTTKQAIRLLYGQTIAKDLLDVTVSSSSAADAAEETSDANDKEEPSGGSWSAEAHFTNAHYQAKKTVLLLFINHRLVESSRIKKAVEAVYNGVLPKGSSPFVYLSLQIDPRAVDVNVHPTKREVHFLDEDAIIDRISDALQGALVGQSQSRVFEYQTLLTGGVAELPRGNGKGKGKAREMDIDEEQREQPKSADEDESYSGPTPTQLKKKTLSQHKVRTSMQDRTLDSMFPVLNQSQQANSPAAPSPVAQTPKTREIKESQCFLGSVKRLRQDLFKGQHRGLTEIIEKHTFVGIVDLDRCLSLIQHSTKLYLVNHGALAEELFYQLGLRQFGNYSRIRLDPPPDLRTLVALAVDVEEGVKHSTLSKSEIVDCIVNILTEKREMLEEYFSLSISDEGTVKTLPILLRDYTPNLDKLPLFLMRLAPQVNWTSEMECFETFLRELAFFYVPEPLVPEADVEQEEEEKTQEKAVKWQIQHVLFPAMARYLAPPKSLLDRDVVQVANLPDLYRVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ07</accession>
    <name>A0A401GZ07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1100730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618310.1">
        <property type="nucleotide sequence ID" value="XM_027762509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ07"/>
    <dbReference type="FunCoup" id="A0A401GZ07">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZ07"/>
    <dbReference type="GeneID" id="38784314"/>
    <dbReference type="InParanoid" id="A0A401GZ07"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="254"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE87397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="718" mass="79738" checksum="0FD16DB9731459EE" modified="2019-05-08" version="1">MSSVIRGAQFFNETSIVPAAFVEHSATNSPATWREALEASGSAPKSFELIKTLVYKPKTAKNATPVPVVVIAREGTDVISGLLGKKLNLKDLRLGSEELLTEFFALDKNSLSPLALSEQTYPKVITVVDASIFTSSSVFAVHALSSSSTFFLTGKDIHTHLKGLETHGPALHEVDFEALKADTEPSAPAGQSKAAPVKKEREGARIEGAVQIAIGIKKEVDFAAWYTNVLIKAEMLDYYNVSGCYILRPWAYSIWEVIQDWFNARIRPMGVQNSYFPMFVSSKVLEREKDHVEGFSPEVAWVTRAGSSDLEEPIAIRPTSETVMYPYYAKWIKSHRDLPLKLNQWNSVVRWEFKNPQPFIRTREFLWQEGHTAHLTKAEADIEVRDILELYRQVFEDLLAVPVIPGVKSEKEKFAGGLYTTTVEGFVPTTGRGIQGATSHCLGQNFSRPEMFNIFVEDPNDPTGQGKVYVWQNSWGLSTRVIGVMVMTHGDNQGLVLPPRVASIQVVIVPCGLTAKISDEGRKAVNDKCDELAAALNKVGVRTRADLREGYTPGFKFNDWEQKGVPLRLEVGPADLAKDQTLTVRRDNGVKSPLPLAGITASVPKLLETIQADMFKRAQDLYFSRVKPVTRWEDVVPTLDNKCVVVIPWCEEEACEDDIKERSGRAAEPQDERAPSAGAKSLCIPFDQSKWPPIEPGKTKCPACGKDAKQWTMFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZL4</accession>
    <name>A0A401GZL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydroxynaphthalene reductase arp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1102920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618528.1">
        <property type="nucleotide sequence ID" value="XM_027762727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZL4"/>
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    <sequence length="255" mass="27083" checksum="531610750F7996BB" modified="2019-05-08" version="1">MSTTRVAVVTGASRGIGEAVALRLADDGFDVAVNDIPAMAESLEALVEKIRQKGRRSLAVTGDVSNENDVKTVVDKVVETLGGLDVMVANAGTCLLKPVVETSIEEYDRVMSVNVKGVFLCFKYAALQMIKQGRGGRIIGACSLAGKMGVTNLSVYTASKFAVRGLTQTCALEWAKHGITVNSYAPGMIRTPLMMEFSEVASEKNLTTGDTLGIGNIPIAEPSVIGELVSYLVKPESHFVSGEWRNLAEVAIEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
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    </organism>
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        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <sequence length="795" mass="84819" checksum="D790852578CA8306" modified="2019-05-08" version="1">MARVAASKTAPQPNAAAHSVDLRAQDVRRGGAVLDSAHGADSDTSTPIETLPSSAAACAQDQEKFSKVQTRPRGDASSQPSHMGDAMRLPHGNKPAAIAIAALTDGPVAGNDDECRMPKRSQQPTSTLPSDSPTTSTGMPSPASAQQPASRAHHGAGMLKRLTTKLRSPTHASDASAPSAAHTRKLTPRLPSMPKAPRPTTLTNSFVSPGQRQAALRARGLIPAVPHPYKDAHGYMVPLSEQERELDRRRAVLASEPRERHSDSSGDSEEESEAKKIREAWLVRNRVHAQERGSLDHGFAFPSRDNYRINTSVSPSRATFVGMHDTPLLTPSRVECEVYPVDSIPEELQMVAHAPALLEQEDADRERRGVPGSANTGKELPAPPSSVSIAPQSPDIAVPRPAVRVLTPPRSVSSDMTQKVSRWLDESSKSPTPISVSSFGSSSGAEQTSSINVHATNTPRGTPLKRKDKPAPIIITMPSQPPSPSSSVKSCSSPAPAITLSISRSDPLRAQDPHSLTPQPTSARGRSATVAHLPSSAAPPLSSPSSSSGSQNRSRTTTLPALSPTRTVSSSGASASVTTPTTLSHSLENHHHSRTRPFDLGVQQRSGAEKKFDATVIVESPIEDDGSDCLPDFAASSHLLSPQHTLAADKERRKSITLEIFGKKPHVNNDMVPPRAPRPSKSMLSLRKLSSKLQFRPKQTVPISTSTPDVSASSNSAPTSSLPPQTSCPPSAYGRKDRSRTVGVGLRPAHPKDMLSPPRQALSPTMHDRATMLLEAGRIQDEESRRLSEMAFLDY</sequence>
</entry>
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    <accession>A0A401H0G9</accession>
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        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
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            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="protein sequence ID" value="GBE87927.1"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
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            <begin position="658"/>
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    </feature>
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        <location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE87927.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="788" mass="83936" checksum="E264AD6D5988303B" modified="2019-05-08" version="1">MDPILVSSYIPDQPDFSSEFQSPQSNQFDGSPNQGSPYESFDYPQDSAHFPHTPSYNGSYQNSPYSNYSDLPPFDGPDDNNLGLFPESHPSAVNIPEYDPVDFDVPTSTGLLLDDGFMSGLPGHPHISVTSFDPKPSSPGLFDHSSPASSNGAEDDSRSRASSSSSYVHPNSPHMDFAQNFESMRFDSPNWASGPLPPIDRSSPPALKPPSPPQLVIPDSSTSPSVTGMDSPPIINAPDGDGGMPTGPQLHIVPATPVSGGAGAAQSVPFQATLANLHTGGSQGVQPPDVASWNRQSQMQLVSSAQNARLDSSQFADQSFTYPGSDNNHEVSTSGMAYGSETPLSHPAGQGQSHQFLFPQGMQRSRSLSDTSLRPPAWDTPMMNPLGHQGSSAGADGNRLGSHDARRPGTTVNMNDVLPGPSSSPLLSGTLSPSQTQLRHPSSAGPHTVTFGMQPSPLLQPFAFQDFLTPESATCLRRAKSDSIRTHRQVRSEDLRYIHSNPGAPGLSGMASANGMRYPPPSSSQQDFILATRQFLHPAAAAAEPVASITRGSHQRRASSGSRERSPGMGGWSSGASSARASPYPSPSVSPRPGYGALPPADMSMPSMQRMDGGMLGMAPGLGNGAPAEVPMTVSKVNVTTPSTADASQKRRKQPANFACPVPGCGSTFTRHFNLKGHLRSHAEEKPFMCKWPGCGKGFARQHDCKRHEQLHLNIRPYPCEGCKKNFARMDALNRHLRSEGGAECRKIQDEITPASLAAENMQDMSIQAQSNLKPEPDSGWPMGGVMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0I0</accession>
    <name>A0A401H0I0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1201610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618848.1">
        <property type="nucleotide sequence ID" value="XM_027763047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0I0"/>
    <dbReference type="GeneID" id="38784852"/>
    <dbReference type="InParanoid" id="A0A401H0I0"/>
    <dbReference type="OrthoDB" id="2755037at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="78" mass="8766" checksum="D81238E2331AF079" modified="2019-05-08" version="1">MSPKREPERKPELVPPSGFQEPSDPSRVAPEDRPESVRGVGAKEEPENPQLIAHERGEQATDRREGIERKGERGKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H142</accession>
    <name>A0A401H142_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase azaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1203290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619013.1">
        <property type="nucleotide sequence ID" value="XM_027763212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H142"/>
    <dbReference type="STRING" id="139825.A0A401H142"/>
    <dbReference type="GeneID" id="38785017"/>
    <dbReference type="InParanoid" id="A0A401H142"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="2"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="354" mass="37900" checksum="4D1F6E8C1F685FD6" modified="2019-05-08" version="1">MGQLSKLGSGPFVIRAVDIPTAGFGELLVKVESSALNPVDWKIQTRGIFITEYPAVLGLDAAGIVVGFGRGVSGFAIGDRVFTEGAFDNAHATFQQYILADADITAKIPYKLSFDDAAALPVSVVTAALGLFNRDDPASSAALFPPWERGGRGKYAGKPMMIFGGTTSVGQIVIQLTKLSGFSPIIVTASLHNAKLLKSYGATHVLDRRLSASELRSAVTDITSLPVKTVYDAVGLRDTQNAAYDILAPSGTLVVVLDDAVDPSKKTPEKKIVRAEGDTYAVENRRTSASLFGQLTSLLERGLIKPNRVEVLPSGLAGIPEGLERLSNNEHPPDALYTVFFHIDFRNCCDYPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H179</accession>
    <name>A0A401H179_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1204120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619094.1">
        <property type="nucleotide sequence ID" value="XM_027763293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H179"/>
    <dbReference type="STRING" id="139825.A0A401H179"/>
    <dbReference type="GeneID" id="38785098"/>
    <dbReference type="InParanoid" id="A0A401H179"/>
    <dbReference type="OrthoDB" id="2801388at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="220" mass="23909" checksum="851D9C0BE344BAAB" modified="2019-05-08" version="1">MVTLWEITKEALNPKEPSSAYIEECVDDSAMSVLEASMAPKKKTVQFDDNTTEKSAKCPPNVPASQVPASILKPMSDPFVVPRGGAKASLPSLGNRATQYSYKMPVEDKVNVQDIFECIQNEVRISLTHRELMALCPEIRKLEKEEITVKGVTTTGSFEAVDGKEVAKALLVDMSDGGGPLIVADNSLPLRAIDALVEGKESAECILDQGSQIIAMRWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H197</accession>
    <name>A0A401H197_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1203890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619072.1">
        <property type="nucleotide sequence ID" value="XM_027763271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H197"/>
    <dbReference type="GeneID" id="38785076"/>
    <dbReference type="InParanoid" id="A0A401H197"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="469" mass="51532" checksum="220669774ED327CD" modified="2019-05-08" version="1">MSLAHDQTTVNLISARVRAALSSLRTLTTIPESVWLPWAKEHLDEEYFEASWSIYRGIRCTRLLRSLQRALEDTNFDWQSIGSGDPRVAAAFKDDTGCSDGEGEREEVDCGENKWWMTPPGVANPSADTVHRDTPPAPAPASLTGDHSVASERNSPGGVVSMGVGMESADVADTQRQTEQTEDIRFLKPQLRRKNQLRRKKVAAKSASILKNPDEKAGTLEGLSMRKRVRADDEGELQDAIGGISDGAMGLSRQMETQLTEVNLPVQRRGHKRRACVRSVPTVEDSEEEPVSDKATQKGKRPRFEKEGDAQVAAETKICKNCRAAGVEQKCDRSSNRACTYCRLKKQKCIVPGEPQLYITVGRKKKGYTLPSPFISNLGSPRVTPVASGAGRELSATSSKSVSDDIYAFGKPNGPSESYSPLPGGADPDIARIWREVIRTREDVVALRESVNGLVRDVIMLQKQLNSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1P0</accession>
    <name>A0A401H1P0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">cAMP-dependent protein kinase type 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1300950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619193.1">
        <property type="nucleotide sequence ID" value="XM_027763392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1P0"/>
    <dbReference type="STRING" id="139825.A0A401H1P0"/>
    <dbReference type="GeneID" id="38785197"/>
    <dbReference type="InParanoid" id="A0A401H1P0"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000354">
        <property type="entry name" value="AGC/YANK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF30">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 32B ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="286"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE88280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="438" mass="50499" checksum="13D14394AFFE89C8" modified="2019-05-08" version="1">MGGVLCCCSPPVDFDGEVDLYHFDLNRAVGRGAFGKVRIVEHKQTKQLYALKYIDKARCLKQKAVANIIQERRLLEEIDHPFVVNLRYAFQDDENCFFVLDLMLGGDLRFHLERLGRIPENVVQFWTAELSSALAYLHRQRIIHRDIKPDNILLDAMGHVHITDFNVAIHYSERRLHTSVAGSMAYMAPEIVGRKGYTWWIDWWSMGVVIWELLFRRRPFDGRTHEKMKSSIMKDPIKLPSIADQYCSPEGQDVIMQLLDRNPRTRLGCKSLRQGIADIHSHPWFASIDWESLENKECQPPFSIDMNKLNFDVSHELDEFLMVERPLTHSRRKAHPNLEKMKPEMRQLVEQFTVYDYSKTKRISYYPHNEPIITAGHTIDTEPEPVMLSATNSVQPTESIVERSHVNTLSGEGDRPGHSTPHSRSGSPDPAVSTRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1R8</accession>
    <name>A0A401H1R8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1301580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619256.1">
        <property type="nucleotide sequence ID" value="XM_027763455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1R8"/>
    <dbReference type="FunCoup" id="A0A401H1R8">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1R8"/>
    <dbReference type="GeneID" id="38785260"/>
    <dbReference type="InParanoid" id="A0A401H1R8"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="32234" checksum="5639E1D7CAF4DE82" modified="2019-05-08" version="1">MADLVDFMLDLMRRLPPTHVEENVASLVAMCPDYADDLLGSVDQPLKVMTDRATGKEYLICDYNRDGESYRSPWSNEYDPPLEDGTVPSLRLRKLEITANEAFDTYREMYYEGGVSSVFLWDLDDGGFAGVVLLKKILNAASPTEPSGSWDSIHVFEAAERGRQAHYKLTSTIMLQLVDRSTASGTVKNEKGVAEDAKREGEVVLSGSMTRQTEQDFPLQDQSSHISNTGRMIEEMEIKMRNLLQEVYFGKTRDVVFDLRSVDDLEKARRQRELQKELVGFIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H278</accession>
    <name>A0A401H278_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1303150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619412.1">
        <property type="nucleotide sequence ID" value="XM_027763611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H278"/>
    <dbReference type="FunCoup" id="A0A401H278">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H278"/>
    <dbReference type="GeneID" id="38785416"/>
    <dbReference type="InParanoid" id="A0A401H278"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="565"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE88499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="845" mass="96321" checksum="DF8B020FE29B78C8" modified="2019-05-08" version="1">MDKDNRDDFTFAKLSDLKVPVTFRISQLEGTRKPHTFTEVLEKPELRFYGVQQSPNFSDLYVTCQLVADNKPLTIPIRTAFKSFKKDYTWNEWITLPIRYCDLPLSSQITFTVWDIAGPREAVPVGGSTFRLFGKKWSLRRGKHRLFLWPDREADGSIESTTPSKVGSRDEMGRLEKLVKKYERGDLPKSDWLDAMAFRKMAEIHAAETEKSENLFLYIDLPRFDFPVVFSEPDASNVASTSAAVPPASTPVPSTPSAFAADTQLWTVIDPDIARENPVEDKHRRLVRSHRSSPYDRELKPNAKIRDDIAEILNYAPSQPLTGEEKDLIWKFRFYLTRDRRGLTKFLKSVTWRDPSEVKQAVEELLPQWTEIDIDDALELLGPNTVDSRVRAFAVKQLTRADDDELLLYLLQLVQALKFESLASDQRSIRSTTSAISYDDSGLADFLIARAVRNPILGNRFYWYLMVEVALDDRVVAKMYGRVVFKFMEALQSAGVAERRDIMRRQGELIATLAKRAKDLRTSKDPRPKKIEKLRTFLAESKNNLASMPPLPLPLNARIEVNGIIADKSSVFKSNMFPMLLYFQCTDGSEYPVIFKDGDDMRQDQLVIQLFTLMDRLLRKENLDLKLSPYDVLATGPSQGMVQFIPSKTIAAIVSEHGTLLNYLRAHSPDEGSVGTYGVEPGVIDTFVRSCAGYCVMTYLLGVGDRHLDNLLLAPDGHFFHVDFGYILGRDPKPLAPPVKVCKEMVEAMGGVQSVHYTRFKNFCFTAFTILRKSANLILNLVTLMVDANIPHIKQRDVHEQLLGKFCLDLTEELAIEHFEKLLNDISPFTAVLDRMHDWAQYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2C7</accession>
    <name>A0A401H2C7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1304020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619498.1">
        <property type="nucleotide sequence ID" value="XM_027763697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2C7"/>
    <dbReference type="STRING" id="139825.A0A401H2C7"/>
    <dbReference type="GeneID" id="38785502"/>
    <dbReference type="InParanoid" id="A0A401H2C7"/>
    <dbReference type="OrthoDB" id="2687560at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="394" mass="44060" checksum="2385010B311043C8" modified="2019-05-08" version="1">MYAHSQIETCSPRVLWREHRKTRRLREWDSLPCFRLRLENRPLFECQECRFANAFGIICPWCLCACEEPLYRGVRRRVSSPSLLSNAQKAQLKRIERHSCAALRESRFTAPCTSKLVTGPGERRKRHRHAAIYSATDVVAQASVDEGLQSVALHLMQLQKDPVSPATSPMPSAELEDGDASIEVVHIPPSPPTSSTPSHRTLRHKPGRLVLHQRSSGSLRRRATISESTAPHRQGRSMRFPVPSGKVDALSSASQPRHTEMDVPLGHPRRPLYTAIRNNMSPPRICEAPKFTGHGPPLPAVDDRVSRSLDLPRPTPDALRTLTAPQPPRFSTLDMHTGWSASGLAELRMGLARESAGEGVPYKYSFRDSTHDSPTKKEGKGLRGGLRYLLSRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2F4</accession>
    <name>A0A401H2F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1400200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619528.1">
        <property type="nucleotide sequence ID" value="XM_027763727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2F4"/>
    <dbReference type="FunCoup" id="A0A401H2F4">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="GeneID" id="38785532"/>
    <dbReference type="InParanoid" id="A0A401H2F4"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="558" mass="61885" checksum="52EA1BE9FB8326D5" modified="2019-05-08" version="1">MEYKLISPLVSRVVRALEVSHHKDLTYAQSLLVNDDLSPVGPEKRTWGTWNFVAFWIADSFNINTWMIASSMVQLGLSWWQAWIAVWVGYGVVAPFIVLNARPGAIFHVTFPVVARTSFGMWGSLWCVFNRGAMACIWYGVQASIGGSCVLVMLRTMWPSVNNIHNSMPASSGTNTRDFMCFFLFWLISLPAIWIPIHKVRHLFTLKAIIVPVAGISFFIWCIVKARGVGPIVHQPSQLRGSVLGWAMVTSIMSCVSNMATLVTNAPDFASRSRRPSDAILPQLITVPLGFSIVSFLGIIVSSSSQAIYGEAIWSPINLLGMFLDDHPSHATRFGVWFISASFIIAQLGTNISANSISAGCDLTALFPRFINIRRGGYIAAIVGMCMLPWNLLKSSNSFTNYLSAYSVFLSSIAGVMITDYYVIRKGHYRIKDLYRTSRDGWYWYTFGVNFRAYAAYISGILINVVGFAGATGRSVPLAATRIYQLAFFTGFGVSALVYWGLNWCFPSHGAAITFEELNVSDEGMNDLDSDILDRRISDEKGEKNRDGDLDDVLPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2U7</accession>
    <name>A0A401H2U7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619680.1">
        <property type="nucleotide sequence ID" value="XM_027763879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2U7"/>
    <dbReference type="GeneID" id="38785684"/>
    <dbReference type="InParanoid" id="A0A401H2U7"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="614" mass="68296" checksum="663688D59525353F" modified="2019-05-08" version="1">MEIPRILPPPSSGSEARRRDRRIPRERKDGIGAGDFLRDDTLERHVHSAVFDEECAAYSKEIAKGPPSDDSDADYSDRSSLWETDSSSSVSSVESSPYDVSKLEAHLYYFGIRGSRRWGPKLIFRTSKDVFTVPSGPEQDPRLMRLLPVYEHHKLGKDNLWATIRSKVVELLDQQNIQHSSVDLVHFSWVEENEDVEDVEDNKDDEDIEDVDIKIAPYGTVVTTPVTIWEHGIFDVDVAYRESVARGFSGPELFAPVSDLDPLKAVIDPVTTALGLPIAGLKMLKSRGTMGFYFRVGKVLYAVTARHVLFPEDEGNNPYSYVAGPKKKVVLMSTKAFTTFLISIQGHIGTLNNTVGVLEKWVTALTARSEGSGPNAEQAAGELELKKFFVKVKKQWTKPKDRVIGHVVWAPPVSVSTAPHGYTKDICVIKLDEKKFSQNFRKNVLDLGPEIDAAKFISLMYPRIDAPSDFDYPAERLLELRGVLSAEEIRTPNNKDHKGDPMRYIIKRGLTTLTTIGCLSGFESHVRHYFALGSRDSVEAAVYPYDNDSGPFSRGGDSGSIIVDALGKVVALLTGGTGPTDSSDITFGSPMYWLWEIIKAQFPGANLYFEDDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3A3</accession>
    <name>A0A401H3A3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1403240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619829.1">
        <property type="nucleotide sequence ID" value="XM_027764028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3A3"/>
    <dbReference type="STRING" id="139825.A0A401H3A3"/>
    <dbReference type="GeneID" id="38785833"/>
    <dbReference type="InParanoid" id="A0A401H3A3"/>
    <dbReference type="OrthoDB" id="2801477at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17428" checksum="43CA87164D45483D" modified="2019-05-08" version="1">MLLPPPAPFDNDEEEAVPIDDDHVLAEVVLARTRERSYPGYLDELAAHLNQPQLPMLTRRFLYDQIHRHDPDAVSSNVVDLDDCPIVVSKISVFHSAVAIFYAPSDISGIHGMRRERIRSTPSWHGHPRRDCAFAVEDNSQPDFKGMSVAVQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3N1</accession>
    <name>A0A401H3N1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1500260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619937.1">
        <property type="nucleotide sequence ID" value="XM_027764136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3N1"/>
    <dbReference type="STRING" id="139825.A0A401H3N1"/>
    <dbReference type="GeneID" id="38785941"/>
    <dbReference type="InParanoid" id="A0A401H3N1"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055105">
        <property type="term" value="F:ubiquitin-protein transferase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019516">
        <property type="entry name" value="Glomulin/ALF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15430">
        <property type="entry name" value="GLOMULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15430:SF1">
        <property type="entry name" value="GLOMULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="550" mass="59902" checksum="8377351B8A20F6E5" modified="2019-05-08" version="1">METLKQDLKLADGQDLSVALISLITSAVREDHAAYTLQQLSQSISHARCAAALEPLTLLPLLISCPYDGADKLIHIMGQESSAKEVVMAVQEVAEHLEYLSQADEQVEGVDHGLSPLKQIDRLVRLYAQCVPRLPRRNKLPSQVMKPLLSELASLITQFGGSADDDGRALVASVSESVLSIDKWVSSDSAYDVDERSRCGHILAHLLYSTVEACVNSIQTNLARVAFANQFPRLVVPNSAGVNVATGDDVVSKAWSALDALGVTPSNLESRPSRVALVLLAHLPSYTLSLPLLTSFFPVILTSVQANVALDEVLYHLISSIGPLRLQYPRPDLPSDLIVPLAQLLPQLAGVHPDPSTRHQTFRLLSTVLSLTPSPMRLHLLHELLTDSDLSPQMRVAAVGLVKEAVLEALATAPGSAESDRNVFVSPMFLRALGPLILRPHPPDLFASDDLSLDEFLETPEPLRLVECLAFLYVLLQRDTQNRTGIRDPDTLKRVNANLLLQLRGRLASWNEEMGGSAIHGDHAVMQLGILDMWLDRITSALESISNSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4P3</accession>
    <name>A0A401H4P3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620311.1">
        <property type="nucleotide sequence ID" value="XM_027764510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4P3"/>
    <dbReference type="STRING" id="139825.A0A401H4P3"/>
    <dbReference type="GeneID" id="38786315"/>
    <dbReference type="InParanoid" id="A0A401H4P3"/>
    <dbReference type="OrthoDB" id="3056990at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="471" mass="49110" checksum="1BF621D994B16F79" modified="2019-05-08" version="1">MIQVALDEIQRQTGWVGIVLVRGPEPKRGGSNIYYCFGTQTAHLKSTFLQYHLDFEDHIAQPFAQYLQASFPADVRAKMALPTVPPLTSATVQISMDGTSFIVSSTASGSIGSTIATLASLDTDGAHVQASASSAPTVASSSSAPASATVQVTVDASTPLSLNIRATASANVTNGSMSTSAVVNVVSPLHSHAANCPDSLVTRSPSYGWSRSNSFEEERLANIARNKAALALLSNFTLPTAQLKKTCKKAAKGLPVTRNLGHLSSGQDLLNDTDNSPDSQFEAANPLAPAPVAPVPQVNVILTVIVAPVPEIVGPRTPVVQSSAPISPAPDIVNPPAVITPAPAAPMPDITALPAPIPLVLLCTHAMAPAPDVIAPPDIIAPLAQPIPALPVPSVIEVIPTAAPELDHMAKPAVCLSLSLSDDSHPLWLQKALQVVRILHGVPDSWVNLLEAFIIFESQSGYPTKRANSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H542</accession>
    <name>A0A401H542_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1602270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620478.1">
        <property type="nucleotide sequence ID" value="XM_027764677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H542"/>
    <dbReference type="STRING" id="139825.A0A401H542"/>
    <dbReference type="GeneID" id="38786482"/>
    <dbReference type="InParanoid" id="A0A401H542"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="196" mass="22858" checksum="C52CD23F893EFC03" modified="2019-05-08" version="1">MWTREILFIEMYAGQLLCEVSNWFLKHAVRQERPVDELGAGYGFPSSHSQWMGYFTAFLYCHFSFRHRFISTGYLALDLIRVVVLYFSLAIWAGGVAYSRFYLSYHTIPQVLWGLGLGALFGTCYYTLVELLPSRYPHSVLGKMKAAVIANPASTWFRMRDSWAVWADGGVEAQWLRWRTEWCRIRAEVRGEKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H583</accession>
    <name>A0A401H583_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1602370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620487.1">
        <property type="nucleotide sequence ID" value="XM_027764686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H583"/>
    <dbReference type="STRING" id="139825.A0A401H583"/>
    <dbReference type="GeneID" id="38786491"/>
    <dbReference type="InParanoid" id="A0A401H583"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="9945" checksum="6433143CA9CCF0D8" modified="2019-05-08" version="1">MDRARPNDSPEKVKHSIDAIIAALRGTKHLPDLFESVHVDSKIPIEEAVRTLSGYAKDGLFDHIGLSECRAEMLRQAHASGSSYELLAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5N9</accession>
    <name>A0A401H5N9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620670.1">
        <property type="nucleotide sequence ID" value="XM_027764869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5N9"/>
    <dbReference type="STRING" id="139825.A0A401H5N9"/>
    <dbReference type="GeneID" id="38786674"/>
    <dbReference type="InParanoid" id="A0A401H5N9"/>
    <dbReference type="OrthoDB" id="3263117at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="178" mass="19287" checksum="A07B5B43ADA9F1B4" modified="2019-05-08" version="1">MTNDTACDVQTTVGRVISISGCHRIPCLKVVKNLICTPFVGAFNPVKHIAHSASVAYCTLPGGTQYAIFHVPWTKTTKQLGTDIIATEFGDPSSAVIALRHHLQANARVPVHAPFFAFKMSDTTSWVLMTHDWFLNRANAAWAAASFEHLTGHCFRIGGVTELLLCGTHPDVVAMQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5P8</accession>
    <name>A0A401H5P8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1700910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620679.1">
        <property type="nucleotide sequence ID" value="XM_027764878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5P8"/>
    <dbReference type="GeneID" id="38786683"/>
    <dbReference type="InParanoid" id="A0A401H5P8"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="124" mass="14492" checksum="D33BA0B80AC37970" modified="2019-05-08" version="1">MNRTFVPNQSLTIESTKSLLIHFLLPEILIWGPWNEKVDIWTFGCLIFEIVTGGVLFKYKPFQRFNLDELSYLLYTMLCYTCEDFSADQLTVSKWAGRFFDSTCNLGANPLSFRVVYQESQSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H684</accession>
    <name>A0A401H684_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="10">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1702480</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620835.1">
        <property type="nucleotide sequence ID" value="XM_027765034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H684"/>
    <dbReference type="FunCoup" id="A0A401H684">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H684"/>
    <dbReference type="GeneID" id="38786839"/>
    <dbReference type="InParanoid" id="A0A401H684"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000016">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="43"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="128"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="343"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="11">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE89922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="448" mass="50349" checksum="D961F30B02E8FDD2" modified="2019-05-08" version="1">MVVFVRSISCGLRQSRTATVPLLRRGFANSVSRLQDKIVVKHPVVELDGDEMTRIIWKKIREELILPYLQLDIKYFDLGLEHRDATNDQVTVESAEAILRYNVGIKCATITPDEARVKEFKLKQMWRSPNGTIRNILGGTVFREPIILKSVPRPIPGWKNPIVIGRHAFGDQYRSTDIIVPGPGKLQLVYTPADGSKGATYDVYDFKGKGVAMSMYNTDDSITGFAHSSFKMALAKKLPLFMSTKNTILKKYDGRFKDIFQEVYEAQYKKGFEAAGIYYEHRLIDDMVAQAIKSSGGFVWACKNYDGDVQSDILAQGFGSLGMMTSELITPDGKTIESEAAHGTVTRHYREYQKGRETSTNPVASIFAWTRGLLHRAKLDGNDALSAFCQDLESACVEVIDEDGVMTKDLALAIHGKDMKREHWVVTNVYMDAVHDKLRKKMEARAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6C2</accession>
    <name>A0A401H6C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1702880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620875.1">
        <property type="nucleotide sequence ID" value="XM_027765074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6C2"/>
    <dbReference type="GeneID" id="38786879"/>
    <dbReference type="InParanoid" id="A0A401H6C2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="71" mass="7273" checksum="769165BED7059396" modified="2019-05-08" version="1">MHAHNIHNTLNTGGDSTTEVDVLTFDGGVEACAGHDGTSTPSVIRNSADDSAGVHRACIIGLSSHPYNGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H742</accession>
    <name>A0A401H742_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1900940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621158.1">
        <property type="nucleotide sequence ID" value="XM_027765357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H742"/>
    <dbReference type="GeneID" id="38787162"/>
    <dbReference type="InParanoid" id="A0A401H742"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8497" checksum="9654F6B9CF3567B9" modified="2019-05-08" version="1">MRANVVSQRLPAARQEGTDEKSFDDMFDRLLSRQDENRNPIGPEELTQTAEAITLLVHNVQVLTSLSSVVQCRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5I3</accession>
    <name>A0A401G5I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0102960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608335.1">
        <property type="nucleotide sequence ID" value="XM_027752534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5I3"/>
    <dbReference type="GeneID" id="38774339"/>
    <dbReference type="InParanoid" id="A0A401G5I3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="12974" checksum="5ADE7713F3667113" modified="2019-05-08" version="1">MYNAQDPHVASTDISTHYASYNQAQTQYHTAYMQAQEPHLVGNQAFIPAFAPPGAFAPPGRGFSFTQQVFTSQGYPQSFGLSSPQEFASPAAFAMAQGCSVSNSSASYGLPGFQNPQLGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5M8</accession>
    <name>A0A401G5M8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein NIF3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0103450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608383.1">
        <property type="nucleotide sequence ID" value="XM_027752582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5M8"/>
    <dbReference type="FunCoup" id="A0A401G5M8">
        <property type="interactions" value="533"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5M8"/>
    <dbReference type="GeneID" id="38774387"/>
    <dbReference type="InParanoid" id="A0A401G5M8"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="282" mass="30630" checksum="3D435DE949C5ACFD" modified="2019-05-08" version="1">MSVVKHICRALERVAPLRLAEKWDNVGLLLEAPQQRPDAHGVLLTIDLTTAVVDEALSSGTAFIVSYHPPIFKPLTSITLSDPLQHSLLRCAAAGISIYTPHTALDSVTGGINDWLCQVVTNWTTPKEVEYIGDADPEGAGGVGRLIKFDSIPMKELELRIKQNLKLEQIQAAYTSAWDITNVESVAICAGSGSSVLLGVDADVYFTGEMPHHEVLAAVASGRNVILCGHTNTERGYLPMLAEKIAAELQLEIREASPALQTPLSKLQVRVSETDHHPLWFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6A6</accession>
    <name>A0A401G6A6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0105660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608597.1">
        <property type="nucleotide sequence ID" value="XM_027752796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6A6"/>
    <dbReference type="FunCoup" id="A0A401G6A6">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6A6"/>
    <dbReference type="GeneID" id="38774601"/>
    <dbReference type="InParanoid" id="A0A401G6A6"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="233" mass="26203" checksum="70CBBE4490CD52E2" modified="2019-05-08" version="1">MPIFTFALGTWQVQRLKWKVALIDELEEKLHLEPMLLPKQINVAAIPDFTFRKVSIRGHWDNDHAMLLGPRVRDGTIGYHLVVPFIRSEGSTVLVDRGFVAKALAEDAKHLKEDGEVEVMGLLRTSHVRNSFTPDNHPERGEWYWADVGQMAEQAGGVKAGVQPVFVEEIFEGHGGDAASRLAHGIPIGRAPIVDVRNAHASYVATWYSLSAFTSFMFIRLLMKRRAQARLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6H8</accession>
    <name>A0A401G6H8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0106520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608683.1">
        <property type="nucleotide sequence ID" value="XM_027752882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6H8"/>
    <dbReference type="STRING" id="139825.A0A401G6H8"/>
    <dbReference type="GeneID" id="38774687"/>
    <dbReference type="InParanoid" id="A0A401G6H8"/>
    <dbReference type="OrthoDB" id="2754405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019510710" evidence="1">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="217" mass="23660" checksum="CD392B75F703B3E0" modified="2019-05-08" version="1">MNGCHTSAYTWNFLLATAGVVAAQSGSDSRSFAAAVQNINGMSSIFSLIPVLTGKVQNIKLIAARTFPGSLALAGLGAGRVLTKLQVGMLLFSCELYRNVVGEFSYRHNEYVNVFSPSLIHIPTGTPERHASNVIINHNPSEDCMVEAWFQTQGRPAQVELYQTGNERTFLGMLVYMLIYSMETFLGLRTAATRTRLVLIGMQATAALSWMCAVCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7G8</accession>
    <name>A0A401G7G8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0110020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609033.1">
        <property type="nucleotide sequence ID" value="XM_027753232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7G8"/>
    <dbReference type="GeneID" id="38775037"/>
    <dbReference type="InParanoid" id="A0A401G7G8"/>
    <dbReference type="OrthoDB" id="3335429at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32428" checksum="DB2531D65C641460" modified="2019-05-08" version="1">MSTTHGCEEYDFVIRSIPDDVKFKVSRTRLAAVSQVFDDMFACCDKGYVLNTAEDDDRILDLHESAASLSILLCLLNATLEPCNVVGPPSESANLTPIQSIIPDAAIPIPILFILLSLADKYMLCNSVVDILHLHLAAHTSTYPLRVYGYAVERGLDDIAAQASKHLLHPPLSSYTSKDIAVIPTAQAYHKLVLLHSCRIDRLREVLMGEMIFPHGYGECTKHSQYTTVIWEERKKTVAAEVLAGTDVTAEMAEVQRKFDSCETCSRACQAALEMLEYKCAKIPRRVDQLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G824</accession>
    <name>A0A401G824_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor IIIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0112100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609238.1">
        <property type="nucleotide sequence ID" value="XM_027753437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G824"/>
    <dbReference type="STRING" id="139825.A0A401G824"/>
    <dbReference type="GeneID" id="38775242"/>
    <dbReference type="InParanoid" id="A0A401G824"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="522" mass="58347" checksum="DA445ADE76D78045" modified="2019-05-08" version="1">MAGSPVLSASTVVLQKRKRTTEPLVLHLASPPPGCDVLSASESEYEPSSAVIRIDSDSGEVASWKGENHDPKRRYKCTFDGCTKAYSKPSRLAEHERSHTGDRPFVCTTCDKSFLRECHLQVHARAHLPGSERPFACEEPGCGKRFWTAPHLLAHSKVHTGEKPFKCAETCCDAAFSKHHQLREHICSAHRPPGTKPYRCEHAGCTKSLPNNQKLRAHMKTHDNKRYTCVHESCLPAEGALPTYYPTWSSLQQHMRSAHRPTCPYPSCNGKTFSAQAGLRAHLKIHAQRDAEADLDKMGNGSADECEDEKPRKRRRGGELGRDWICEIPGCGKDFKSKHALTTHTNVSHLGRRDFVCSHSDCGRAFGWKHLLQRHVAKVHSNDPLNSDSEEDHEASDEAEASGIQAQEQPRPEESLAIDFITGQAYATHSREQMNCLKVLKCPHPHLPAIFVVDDTLAPSGSGSRQPESSSHTGLCQYVFSRAYDFRRHMRVEHGIEVEKEIVDEWVKEQKEAKATSVRSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8C5</accession>
    <name>A0A401G8C5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0112680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609296.1">
        <property type="nucleotide sequence ID" value="XM_027753495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8C5"/>
    <dbReference type="STRING" id="139825.A0A401G8C5"/>
    <dbReference type="GeneID" id="38775300"/>
    <dbReference type="InParanoid" id="A0A401G8C5"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="411"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1202" mass="136966" checksum="EEBFFBC0FDAAFC3E" modified="2019-05-08" version="1">MEIFMQNIGPSVTQYDLKDMIADVLHSPAFTRSSGVLNFEARIFQHGRRNHLRQGTMTLPSEDIGWQFLQEYGGPQPKKSIGRTRITFQPSRNKPNAQVLEMICRLPYVNQRLLREKEERAQELDARSVSIRTIQFGRECRDGVYSVEWEKHCVGAHLIFNQERKEFRVEVPDSTNTRFISIRTAQIFSLSASMDDPHAPTVFFSLNHPPAFESRPSDLETLMSNLLSMKNVPIRQRWCAFDDDHLRVASFTSLSMRLVCKASNDLDNFRSICRMTHTRFDHSSYPIQYRGLFSDQVRRTYSDWLSRLVWPVAFQVEALARAHFIDLKELLGLRESIELMVRERGASSTAMFLHDFASHAKTLFWYGEESELSQESVEILFSRLSREFLSKPIPPMPPPSEDNFDCLHVIVTPTTMYLEGPFPERSNRVMRTYPGNEDSFVRVSFADETRLQHRFDREVDGRAFVDRTIKNLLLNGVTIAGRPFRFLAYSQSALKEHAVWFVKPFTDPKRGRIDAPTIIRSLGSFRHLPYDRLLIYCPARYGARISQAFTATDASVSVEADEVFVLNDVQDPDGRWTFTDGVGTISAELARTIWGKLCAKRPRGRRHKAYPRTFQIRFMGSKGMLSVDYKLSGRVVCLRDSMIKFDAPQSLDIEIARAFDKPGRYYLNRPLIMILEGLGVPCEVFKILQDNAVRDAEGSVLSLERAGRLLEAHGLGTSYRLTSTMLSLHRLGVGPLSEDVFWQQMMDFAVNHVLRELKHHARIPVPDGWTLVGVADVHGFLKEGEIFACIDSQDHSGLIYLEGPTLISRSPTIHPGDVQLVRAIGRPPPGSPFEKESLRNSVVFSIKGARPLPSCLGGGDLDGDVYNVTTMRSLLPQKTYHAADYDPAKKKLNDHESTMHDVAEFVAEYINSDTLGIIAINWLIIADQSPKGILDLDCLRLAQLHSDAVDYPKSGMPVPLEHIPRLKFKAKPDWNAPETLTRETPDFYESRRAIGKLYRAIELPALRTVARASSVQRRHLEDSHEESSRYVLDEFYSEEPHLDDYVRLAVEDRVGQFLPLQDITFNDDVIIGLWELFHSYVSQLRAICTDNTLSHTRSAMLTEEEAVIGTIVAKCSQPRKRKDLMSQMREQTSVLINGMRAEISGDEDMTPDESLERAWIAYKVALIETNYFGARSFAWIALGEIFDAIRNIEDADKNLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8R3</accession>
    <name>A0A401G8R3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chromatin structure-remodeling complex subunit rsc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0114360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609460.1">
        <property type="nucleotide sequence ID" value="XM_027753659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8R3"/>
    <dbReference type="STRING" id="139825.A0A401G8R3"/>
    <dbReference type="GeneID" id="38775464"/>
    <dbReference type="InParanoid" id="A0A401G8R3"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="402"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="720"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="771" mass="85843" checksum="A4AFB60EA18DC550" modified="2019-05-08" version="1">MPITAPQKHEIDDVINVLFNASSARGKRRLADMFLELVDRQSWPEYYEVIPEPRCLDGIKATLEKNKYKDPLNVYNDLNLVFLNALYYNEESSQISKDARTLKAMLDNEWKQRSILPTPRESPPPSSAQKTHKSATAAASAPAPVATAAPLAKTQPAQHASIAVAAPAAAPQAVQVTVAPKSPERQQTPDMDVDVGGTPEPEGVAIDTARDGESEEIVSQLEKGLPRWEGFGDVGWAEGLDPERQLDIVRAISKHVDANGTRLAASLDALPEESSIPELSFNFPLSLSLIENRTLMKYYKSSKDFDKEMSQLFLKARRWFEPGSEAYGNILVLQRLYHALASSSPPSGPPYASTTNFASLRAGPGTAKPMHTTEPEGVHGVTTYRVSTKDRTFVDEVQFKGWSIHLADWLHMSNPDDPSKPIVGQVFRCFTSDEPARKGQPGVTVCWYYRPEQTWHPANRQFWEKEVFKTSHFADHPLEDIIEKIACQFTARHIRGRPRPPFWYPGWPLYVCDSRYNDRERIFVKIKNWNSCVPEEVRKSTEFMPIYPFERTVFPRRFASPFVSGKNVKGPGGIGDVIERVEGEKIEGGGTGRKRPRRAAAATTAGSSRTEHTDRVGPSKGLYVGASTGAPAAQVPYQYAQTTQYPRPHDRTVVTAAGGLANLGGNISTERLPPETAKQFDRDPQTNEVLWFASPPVDMAHTPAPQHSLKYLHFMTKMRKNAKRPHDAVEGDGNEQTATAPKRKKPRSTVSEALQSMMTKFRVDLSTPPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9B6</accession>
    <name>A0A401G9B6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock protein 70 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0116390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609661.1">
        <property type="nucleotide sequence ID" value="XM_027753860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9B6"/>
    <dbReference type="FunCoup" id="A0A401G9B6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9B6"/>
    <dbReference type="GeneID" id="38775665"/>
    <dbReference type="InParanoid" id="A0A401G9B6"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000021">
        <property type="entry name" value="Heat shock protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="632" mass="67177" checksum="044C403E43821C96" modified="2019-05-08" version="1">MATPNGTADAPIEVSSAPTVVGINFGNSYASIAVLTKEGLADCIANEDGERQIACTLAFHGEELYVGNQAKHQLIKHPQNTITGFRNLLGKKFSELPSNKPTVSAPVIQHPDLPDVPAYKVQVLQASPTPLSTTASNTPAASHAATPRSEPTPAERVLTVSEVTIIFLKSLVQSAEDFLGRKVQGAVISVPAWFEEAQKVALEEAAAEAGINVLQLLEEAGAAAVTTTFGPPAEGLKADRTQLLVDLGSSGLELSLLSIRDGLAYSLATLSDHSVGGDAIDNKLMKYFAKEFTKKTKTPLVVCPAGDAQDRRAEAKLRLAVEHTKRTISASPGTATCSVESLKDGLDFTGSITRLRFDMEVRSVYETVLARVRELVAVAGLDLYDVDEIVYIGGSTSLPGLDDALAQSFTGTVVTPFTTGTVVGGGVGDPTTILARGCALQAKVLALLAEGTEEEREVKKAFTRGSKWTQAKATSKTIGMLFPEEGAGDGTLGGQWIPAVLRETPVPCRRVVTFDVDLGEGEREKRAGFEVWEVKEGIKIENVKPPRGEEDEAEEDEEEEAEIEVKEKTIEKENLLASLVLVAKEAKLVNGRWTTTLEVQFLINDSGDIEVSASEVGASGKGEKTVVSIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9E3</accession>
    <name>A0A401G9E3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609719.1">
        <property type="nucleotide sequence ID" value="XM_027753918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9E3"/>
    <dbReference type="GeneID" id="38775723"/>
    <dbReference type="InParanoid" id="A0A401G9E3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="195" mass="20238" checksum="62180F5BE421925C" modified="2019-05-08" version="1">MAAPRPSQRGDNEAPPAAHPPDVAPRATPFAGAHAARDPSLSASPAALGCARANCARADGSRTRIVRNRSGTPRPSQRSLRCTAAFPPSASFLRAPASICQMALRAETTPDLCAIPCALLLRAHRLPSSQASAQQLSDLIHVMPQTLSAPALASCGASDIFTDPELDTPAHPLGPAHELLLLPRLASARRTLSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9M7</accession>
    <name>A0A401G9M7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609799.1">
        <property type="nucleotide sequence ID" value="XM_027753998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9M7"/>
    <dbReference type="GeneID" id="38775803"/>
    <dbReference type="InParanoid" id="A0A401G9M7"/>
    <dbReference type="OrthoDB" id="3262734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="11102" checksum="B8C7C549436B26A9" modified="2019-05-08" version="1">MIYVIGGYFLTKEQLTTFGAKRGLNIPNGKAYILNSHLLSRGIRSCTAVPVTLPQKVPNSEEPVVCGTLITTHQRDDKAEHFRDCVPFVEDDDDLKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9X4</accession>
    <name>A0A401G9X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0201670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609883.1">
        <property type="nucleotide sequence ID" value="XM_027754082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9X4"/>
    <dbReference type="STRING" id="139825.A0A401G9X4"/>
    <dbReference type="GeneID" id="38775887"/>
    <dbReference type="InParanoid" id="A0A401G9X4"/>
    <dbReference type="OrthoDB" id="3227833at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019206132" evidence="2">
        <location>
            <begin position="26"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="348" mass="36897" checksum="06C7B28EB43D9871" modified="2019-05-08" version="1">MCLRNHGGSYLTWGFFLMLEPQLGAITNILAIVPPAPSSSLTSPSGPTAKAAVDVSFINVDPSIENLIDMLSGSHTGLTSGFELLNAMKLKPAFGVGSPTLEVIAFIERIENTDPNAPDLSEDDLGTAWGHYQFTAGSMTSSSVLTSWDSIGNDAARRLIAAAMKTCKVARHVCFVNGIEANTYLSDTYLETTFEILWQLWKAAGGPIVKGKSKAVPPSDAHTMSTTGIPESSAATQTSGVSASADNAQSSPRTSPPVNDSVPSNSSGTGKLETDTRDSDPSTDELFEWIIDRKLAGNMKLGKKSSSMKKDKLVSIILSAEAMGQPLKAEVETIVQQRKVKKMAALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA20</accession>
    <name>A0A401GA20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0202210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609937.1">
        <property type="nucleotide sequence ID" value="XM_027754136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA20"/>
    <dbReference type="STRING" id="139825.A0A401GA20"/>
    <dbReference type="GeneID" id="38775941"/>
    <dbReference type="InParanoid" id="A0A401GA20"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF14">
        <property type="entry name" value="RETROTRANSPOSON COPIA-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="541" mass="60150" checksum="67EADA813C6DFA75" modified="2019-05-08" version="1">MSTSADNTSNSNAYRIPLLKEDNWLPWKCRVEAILNDKGLQEYVTGKTPKPQPSNDPANRAAREAEISAWGEKDLKAQNVIVLSLGDSQMVHIAGAEMARAMWEQLRTVKEQRGQHGILALCRRFYRMQAKEEDNISSHITQLRQIQEQLHLMGKVVSDEDFRLILATSLPESWDSFLSSYFGAVGGNVGAEGADNVRPQLTSQELIAIILDENRRRHERGERGQSSDQAMVAKGKKHPFGEYKKCSICGKPGHLGNKCRHRDKVKCMNCGKFGHKATDCWAKGGGKAGQGPPMKQQKTECAYEAREVESKEDEAKIAYDNDSDTVSLGSDGKIASFYEWFADSGTTLHITNCREVFATYQALEDHAITGIGPQPTQALGRGMVDVESEVGDRKVKFRLHGVLYAPTAPNSLLSITCLDDAGGRVLMGNSRVILIDKNKHTLAIGKKNGRLYSLKLRPIVPQPARTYTAKEYSPHTWEEWHKIYGHIGKPALMRLYREGLVDGLEISPSPDEINCEACIQAKATRKPFPKETDECSKVPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAH6</accession>
    <name>A0A401GAH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">V-type ATPase assembly factor PKR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0203540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610070.1">
        <property type="nucleotide sequence ID" value="XM_027754269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAH6"/>
    <dbReference type="FunCoup" id="A0A401GAH6">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="GeneID" id="38776074"/>
    <dbReference type="InParanoid" id="A0A401GAH6"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="114" mass="12289" checksum="CDE585BB5E42CFAD" modified="2019-05-08" version="1">MSSSNSTSNSPSSPTTEDNSLFATLLTPGSSLHPTLLFVLDVAFFALFLVLAGLALATQGNLHVLSLIGIEMGLWGSVKWFVYELQLANANEETQKNANRENDTSPSDSKLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAU9</accession>
    <name>A0A401GAU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerases I, II, and III subunit RPABC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0204980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610213.1">
        <property type="nucleotide sequence ID" value="XM_027754412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAU9"/>
    <dbReference type="FunCoup" id="A0A401GAU9">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAU9"/>
    <dbReference type="GeneID" id="38776217"/>
    <dbReference type="InParanoid" id="A0A401GAU9"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="67" mass="7793" checksum="74E47DAA5421D0F1" modified="2019-05-08" version="1">MSSQQGGNAPQGGPIYMLPQRQEMEYLCADCGAKNEIKSREPIRCRECGHRIMYKKRTKRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAV3</accession>
    <name>A0A401GAV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0204930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610208.1">
        <property type="nucleotide sequence ID" value="XM_027754407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAV3"/>
    <dbReference type="STRING" id="139825.A0A401GAV3"/>
    <dbReference type="GeneID" id="38776212"/>
    <dbReference type="InParanoid" id="A0A401GAV3"/>
    <dbReference type="OrthoDB" id="5392202at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30918" checksum="23BD6ED2459AA172" modified="2019-05-08" version="1">MVAHLPPAIKQLLTLRNPHSLPGPPVAQLHDIFTRTFNDARQKNVEKGWLTLTTCTLLTANVPSSVGHLYRFATRDDPGKAESRRSLTEALDKAAVMRESAMKSFIFVGVPRTILTFAGLFEALEDDVKQGLRKESKRTATPENVEAITARGRALWASIYEPHAEKLHNKLGSYHPDFIAFIIQTYGTVLAPLPGGDSEQGNLSRALGSVVGTACLRAEGRVGPQLVSHVFGLLKARYAENLNEEDRWLSTDEGTEWVIRTVDSILDVVKPEDVSGVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB03</accession>
    <name>A0A401GB03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610258.1">
        <property type="nucleotide sequence ID" value="XM_027754457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB03"/>
    <dbReference type="STRING" id="139825.A0A401GB03"/>
    <dbReference type="GeneID" id="38776262"/>
    <dbReference type="InParanoid" id="A0A401GB03"/>
    <dbReference type="OrthoDB" id="3268787at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="360" mass="40760" checksum="A7536B4D8A465D01" modified="2019-05-08" version="1">MMNSSGAQPTSAVPFERHPTLYFKSGDIVLSAPTVSEKVSGQLFRVHRFMLAHHSPVFADMFDVPPPPDEEGYDGVPLVQMADAAEDFASLLSVLYNPSELPYKRLDPNTPALITGMLRLTAKYQLDDLHARLLDHFSADWPCTVDAWEQVEAEIAAAQRARQNCILNLGQVNLPFIDDCFPEPALAIRLACDFGCPAILPTAFYRIARTPATLDWDACRAEGADRKVLARGAMTVRWALLTHDDSMRVMRGREYLQDEIDRIRKEMLGVPMSQKTADGCSHRDMCYRVRSSIRDHVLGKEDRYDPISALKKCMENTETRDHSTGDIRDSLCGSCHLQMETTVYDWKIDFWQRLPSMFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB52</accession>
    <name>A0A401GB52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">37S ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0205960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610311.1">
        <property type="nucleotide sequence ID" value="XM_027754510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB52"/>
    <dbReference type="FunCoup" id="A0A401GB52">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB52"/>
    <dbReference type="GeneID" id="38776315"/>
    <dbReference type="InParanoid" id="A0A401GB52"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19734" checksum="884CAD76F0CA709A" modified="2019-05-08" version="1">MPELFANLATPPSSQQAQIPQPRADISHPPAAPMTAYNQPVNPIRHSRAEFITEDLTKEKPKYGVYVQSTPNNTIVTLTRPNGNPILTLSGGKVGYKGANKATFEASSKCAMGVFEALAKEQEKEDLRWELFVSGFGSGRDAFHKALMAADPTIKAALRRITDRTPIKIGGTRAQKMKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBK1</accession>
    <name>A0A401GBK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0207660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610479.1">
        <property type="nucleotide sequence ID" value="XM_027754678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBK1"/>
    <dbReference type="STRING" id="139825.A0A401GBK1"/>
    <dbReference type="GeneID" id="38776483"/>
    <dbReference type="InParanoid" id="A0A401GBK1"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF22">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019126780" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27534" checksum="09B44BF9D643D1E8" modified="2019-05-08" version="1">MIHLFSLSSLLFAASTLAPLIMGATAADISAFQSALERRYSTAHTLAPNYQFDPRDGWQTVNVTNLQYKYARENQDEGYVGERMLERRVTKKPTAKTSSASKPKSTSASKSSSGGVVDSLSKVVQSLKAIGSAQPVTITWYTGKDLLNPSCWEKPTWHPTDDSFACALTLEGWTDRPACFKFLELCNTPKKCVFVRVVDSCAGCAPGSKHVDLTKSAFTQLADLGEGVLTVQMRSATNPDGWLQNLWGPQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCQ0</accession>
    <name>A0A401GCQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610867.1">
        <property type="nucleotide sequence ID" value="XM_027755066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCQ0"/>
    <dbReference type="GeneID" id="38776871"/>
    <dbReference type="InParanoid" id="A0A401GCQ0"/>
    <dbReference type="OrthoDB" id="2754015at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="146" mass="16725" checksum="33624FCECC41C271" modified="2019-05-08" version="1">MDPVAPSLVWSDSKSVPMEIVSRERRSSSLVRATDSSPEFDRGASRYNIGPYCDVECTATPSTAKGKVDKLPFLGPPDPSYSPPEKWLFLAGFLFFPLWIIGGFWRWREQYDSFAELFRWRCQVMTMLVFVITIGLIFVEVIFRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCR0</accession>
    <name>A0A401GCR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0211370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610848.1">
        <property type="nucleotide sequence ID" value="XM_027755047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCR0"/>
    <dbReference type="STRING" id="139825.A0A401GCR0"/>
    <dbReference type="GeneID" id="38776852"/>
    <dbReference type="InParanoid" id="A0A401GCR0"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="12">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="396" mass="43840" checksum="4B025A97F6F5CC67" modified="2019-05-08" version="1">MPDDADDQSSVPSADPNVPPTPSISDTQAANLQVNTQVAVDRTELLEKARSFLSSPQVVHEDTAAKRRFLAEKGLSDAEVDGLLREVPAAVPLVPPRTYPQPPPSNLPNLLAGVTRILSWIAGGSVGLLLLYFKFIYPRLSQSYHARHALRSHQRNLLGKLTDSVTALKTTQTETFVILPQAEPFKDPAQYGDCHTLDEFVAASKDSRDLPPFSLLRCAIEGLVSQDQKPTTEDIFQTLESKLPWLKSEEEGVQFEAKLWETLSMSPVFRHEDTDGTSVWSYHPPIPPPLPPLMSSLHSLKEALPESMPQASHYQHTLEALSSLTGYISAHTYSYALPRTNFRLGVASPDPQLHPEEEDVRKEIRALKGLVLNRRSFMPAIPRPPSVPRRDVASTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCR7</accession>
    <name>A0A401GCR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0211540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610865.1">
        <property type="nucleotide sequence ID" value="XM_027755064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCR7"/>
    <dbReference type="STRING" id="139825.A0A401GCR7"/>
    <dbReference type="GeneID" id="38776869"/>
    <dbReference type="InParanoid" id="A0A401GCR7"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="354"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="719" mass="78634" checksum="4912175E8E2732AA" modified="2019-05-08" version="1">MAEHLRQSNSRMSSAAGSPSRPSPLSRPHWPWSTYTHRSSSSSVFSTSSSSLASQSMSDSRHSAASTVLLPVATAAKGGPGIPDNAANEESTTRQWSFAAFEWVVRDVHRLRDFVEGPETTDASDTTPENQTESEGGPEADDFEILRESPMLGDSKFKLEIAKTIHFQQTDRSTTPVIKTGPQTLSVYITSLMVDFAHADYEMCTSMFAAIKCQDDRIGERGARAQWVWEYWQNGWVFRQESEVWACPLPSLSSLLENPRIRETDSFVICVQIHSPIGPFFPQQPSAYYVPRDLLDGLEASLDNPNTGDVQFICLERRDAHQELSDSTSLSPITATPMASPSSSSSQSFTPQTVARKRIIYAHADILTRRSEYFTTMFSSSFAEVPGIHYPGGRKIYTVTVEEADFVTIYWLLKWVYANWLLFRKEDDPREAVNGMGAGWSARGFGIRGAADEWEWKAFSKNISTEGHTPGGVSDARSVTSAESAVSGSATSKDKGKYVPDQSQAVAATTTRIASTSKAVPPPPSPSRPSTTNARRPSVPASTNTSGLTVPNVPGSAASRGTKPVPVPISPSKANYTAPPRYPLSPHQQRQRSHPSAPSTDPHPHPTAPPPPASALSMYQIAHRYAMPGLASLALEHILSTITPQAGFPVLLATSAWEELHSLVEDYVVEKWDEVSVSDEFERCCQEVAAGEWGPEGGTTLMALFRRLRSPNAMAYARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD10</accession>
    <name>A0A401GD10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0212720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610982.1">
        <property type="nucleotide sequence ID" value="XM_027755181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD10"/>
    <dbReference type="GeneID" id="38776986"/>
    <dbReference type="InParanoid" id="A0A401GD10"/>
    <dbReference type="OrthoDB" id="3260031at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="609" mass="67221" checksum="F766AEB913B5542A" modified="2019-05-08" version="1">MGVMERETYEQFKTAVIALYPGAEDDRRYTQSDLTQIVQAARMRGVSSRAEEGQYYRDFTRVALFLLSRGRLSTYERDRLYLEGFENPDNPYAISEVHSAAQHILSGSGSASSAVAVSKPSTGMVKLEGNEMDAMWFLANVLQQVMRTSGGGQAPVSQANIQAVVAQNPLPQALHACNFCLAIDHFMRNCPRIEDYIRVRKINRDALSRIILPNGWFVPRDLLGRSMAEHIDAWHDMYPGNLFGDGPGPSAAPLPNVSRDGRDQPLHMVSLWEITKEALNPKEPSSVYIEECLDDSVTSVLEANVAPKKKTVRFDDSAARKSAKRPPGVLASQVPASILKPTSDPSAAPRRGAKASLPSLPSLGNRTMQYSYKMPVEDNMNVQDIFECIQNEVRISLTHRELMALCPEIHKLEKEEITAKQVAMMGSFEAADGEEVAEALLVDVSDGGGPLVVADDSLPLRAIDALVEGKESAECILDQGSQIIAMQRDIWERIGSALQSEKTLNMESANMGINQMLGCLANIRFGFGEMELYLQAHVLNDAPFEALLGQPFFTLTACKTLDFTNGEQHITLHDPNTRQVVTLLTHERHPRPRPTPLPGMGFQDSRSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDD6</accession>
    <name>A0A401GDD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0213920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611095.1">
        <property type="nucleotide sequence ID" value="XM_027755294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDD6"/>
    <dbReference type="FunCoup" id="A0A401GDD6">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDD6"/>
    <dbReference type="GeneID" id="38777099"/>
    <dbReference type="InParanoid" id="A0A401GDD6"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="89"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="401"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="640" mass="71005" checksum="39E47C4E5E2A6558" modified="2019-05-08" version="1">MPPPSSSKQKRLAEKAAKQASKSKGGTDASTSTETPSGSVNGGSSVNTPMTSMSAATSQENLTSMAKLQIATDRSASGVLVSDVKGRDIKIDSFTLSFHGRLLIESAEVSLNYGQRYGLLGDNGSGKSTLLQSIAERDVHIPEHIDIYLVRGEAEPSDVNAVDYIVASAKEKVARLEQRIEDISVEDPVDELALDAAYEELEEMDPSTFEAKAGSILHGLGFSQQMMLRPTKDMSGGWRMRVALARALFVKPHLLLLDEPTNHLDLEAVVWLEAYLSMYNHILVITSHSQDFMDSVCTNIMDLTMKKKLVYYGGNYSTYVRTKQENEVNQMKAYQKQQDEIAHIKKFIASAGTYANLVRQAKSKQKIIDKMEAAGLIEKIEVPKPLRFNFEDVGKLPPPILAFNDVAFSYSGKKEDYLYQHLSFGIDMESRVAIVGQNGTGKSTLLNLITGVLQPCEGNISRHVGLKLAKYSQHSADQLPYEKSPIEHMQSLYAQKFPDKDLQAWRAQLGRFGLSGAHQTAPIKQLSDGLRNRVVFAQLAMEHPHILLLDEPTNHLDMASIDALARAIKEFEGGVVIVSHDFRLISQVAEELWEVKDRKIKNLTKEDITIVDYKKLLVKHSYAALEKAKLFSKTTSKTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDV8</accession>
    <name>A0A401GDV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0300740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611272.1">
        <property type="nucleotide sequence ID" value="XM_027755471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDV8"/>
    <dbReference type="STRING" id="139825.A0A401GDV8"/>
    <dbReference type="GeneID" id="38777276"/>
    <dbReference type="InParanoid" id="A0A401GDV8"/>
    <dbReference type="OrthoDB" id="4230923at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39372" checksum="EABD4D69CD477C8C" modified="2019-05-08" version="1">MCQVLVDGVFAANSSSNLLTEEELLAKANMACTMMGVKAADAPTSFTIKSCKRLKNGGVLYDLDSPTSALWLHTPDVMKVFLEHFGGHNCQLKIHSYAILAEFVPTACRADDDHYLHGIEHFNNYDPGDIESARWIKAPEGRHPNQRVAHLIVRFNAPVPVNNAIRKGIIIAGKRVNAHKLISEPHRCLKCQKIGILHISSECKSIHDTCGSCASIGHKTADCEVDPDDYQCANCQASGRTDWRGHAAWDRMCPVFQEHRRKMADRQPESKYHYFLTADPATWEQLTEVTSALPNTVVAPPHQAVPHDNTQNPRTFSFNWADDVDASTPPPSNKPPRPSQARRAQEQQDAQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE27</accession>
    <name>A0A401GE27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycosyltransferase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0301320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611330.1">
        <property type="nucleotide sequence ID" value="XM_027755529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE27"/>
    <dbReference type="STRING" id="139825.A0A401GE27"/>
    <dbReference type="GeneID" id="38777334"/>
    <dbReference type="InParanoid" id="A0A401GE27"/>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06434">
        <property type="entry name" value="GT2_HAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="466"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE80417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="499" mass="56621" checksum="B5595851FD200619" modified="2019-05-08" version="1">MKLLADSPTVHCHVLLPVRVCGDPPAPLSFFCLSLTPLHCVSLHDRRVMLRLTSDHFPIFVPLGVIGFYRYLWYLIRIAASLVYRPIPLPENPTYIASEDVTIIVPTIDAGDEFKEAAHSWLAGSPKEIIIVTEENMRGPLQELADAVDPARIRVLTVPYANKRLQMAHGIKHTTTDIIVFADDDAIWPPTLLPYVLACFEDQRIGGVGTSQRVQPVGARMTVWEVLAAFRLSIRNIEIASSTHIDGGIPCLSGRTAAYRTVILKDPAFLHGFTHDYWLGRYQLNSGDDKFLTRWMVSHGWGTYVQCCREAELLSTMKPNWRFLKQVLRWTRNTWRSDMRSLFTERYIWTAHPYVAYTMVDKLFNPLTLLVGPCLVAYVVYKSTIPVADGGYHLPWWNVIASYAVWLTATRTAKLLPHLWYRPQDIIYVPAFILFGYYFAIMKLYALFTLHETGWGTRAGIGDPTKATAAADAGDEKLGPPAPAYHDQRQYEQPPIEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEG7</accession>
    <name>A0A401GEG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0302460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611444.1">
        <property type="nucleotide sequence ID" value="XM_027755643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEG7"/>
    <dbReference type="FunCoup" id="A0A401GEG7">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEG7"/>
    <dbReference type="GeneID" id="38777448"/>
    <dbReference type="InParanoid" id="A0A401GEG7"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="390" mass="42960" checksum="313F3E6544191DC4" modified="2019-05-08" version="1">MISENGTEILILDGGLGTTLEDVFHKNISTPLWSAKPIDDDPETIIEAHLAFLRAGADVILTSTYQCAWETFERSGYSRTDAVRIMRKSVALAVEARRRYLLDERNDGNKDTPQKHIRIALALGPYGAALPHAQEFSGLYPPPYGPKGYTPNEKNYNAFGDLDAGARSKKAAIEALTTFHLERLRVFAEDKDTWDAIDFVAFETVPLAREITAIRRAVGLLLGEVGALQMKRWWIATVYPGGHFPGELSPGGGKLTVQGVTTSAFRKNADAALLPRPIGFGVNCTSIEFLPTLLQEATDTIQTVCNDEDYRPLLVVYPNRGDVFDAVNHTWHPSDTQTQGGAWAKYLCDIVRPVMERNIWGGLIVGGCCKTGPEEIAALVRQVKSRDETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GET5</accession>
    <name>A0A401GET5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0304070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611601.1">
        <property type="nucleotide sequence ID" value="XM_027755800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GET5"/>
    <dbReference type="STRING" id="139825.A0A401GET5"/>
    <dbReference type="GeneID" id="38777605"/>
    <dbReference type="InParanoid" id="A0A401GET5"/>
    <dbReference type="OrthoDB" id="2689725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="923" mass="103841" checksum="D97F32E0B4664B58" modified="2019-05-08" version="1">MAGGTRATRRQGMSRSVHVASLVISGGSSSRHAKHHREAVYGAKAIAREQQRAEERYRLAVTGLGAQSLQALSDIREDDIPMGDASAPDNPFANTGEAEGAGAPNTGHDPSSARLQDGMEWEDLPEVLQGDASFVHAVRDIVGSEWKARWYKDARTWRQRVHRMDENWRPLIPDLIDAYLTWKYAPEQPPNVPATTDDPSPYDFMINVMDFYSLASSATISRAEDSRSMAHTLVLNGYLGTSPVFPSMAISLKTLELLRSLRLVKASFSIEAFGSRVFSALGWDSPNWRVLNACPACTYELEGEPPRRWSRMFCMDGNNSLKRIAQVGNRIRGDARVFVDSDYYLSQEFVDKYADEVPPRQTSSTPSNGDDLEEHGQEDDINCGDPEGGDPTDGAFGDIIVPCMENWKAAAADEKNASVSCKAKYPLATIAKALEVLSDKTLAGYDIGCVFEGTIQRSSLGPEWQRCQCRCCVNAFHGYSHNYLCQLTNHPNIIEGMGLEDLETMERIFSASNNLAAITRYASGFRRRLFIDAFFHQWDMEKYANLSTMLFNNYVQALKIIKEDGAALKEAIAALQITHEDLAKWSHEEREYFKSLGEEPEWDIHAMAYVESLQELRTITAHLENTSTQFLATTPDDYIFMELTSGRVVYNADVSRTRKLETNKRYLSERQAKVHHDVIAIEVKMGIARRWQPTDNEYIATVKYISTRKYHRALDNLQRLVVHCKVIRNAVKVYNAAANALVPPHPTLDWTKVSHYSFIDEFHILKDTRNDVHQKEWTRPAVREAMKQARRIAQAHVELERCNVEARCLHTSIRDEELQFTAVINQLKEQQASICGAVEDFCEHRRNVNARHLMRLQRLYALNGFTGAPSPGQRKGSAIMAPPLASSSLAPDLDDDVDPEVEEEEELQGDIGGIVDYMCNLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF57</accession>
    <name>A0A401GF57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611729.1">
        <property type="nucleotide sequence ID" value="XM_027755928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF57"/>
    <dbReference type="STRING" id="139825.A0A401GF57"/>
    <dbReference type="GeneID" id="38777733"/>
    <dbReference type="InParanoid" id="A0A401GF57"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="118"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="370" mass="40003" checksum="E969554997B63461" modified="2019-05-08" version="1">MPRPTVPRVELSGSPYEIGLAHGRLLAPQIHSQLEIYRDIFLENCKFEWPKVLGLAAQYRSIIAALAPELLEEMRGIADGVGGTDVGLLDIVALNSRSEIALGLWDDGCTSLAWNMRGSGKQLLAQNWDWRTSVGENLALAHITQVGKPSIWMVIEPGIVGKIGFNSASVGVCLNAIRASPTSTSLLPIHLLLRIALEHDSVDSAIAAIERLGGAASSQHILIADANGGRGLELSPRGGVYLKEDRNGIIVHTNHFLENNLVDEPPWLSGSPMRLKRARSLCGNIMQDLGCEGLPQGVNPALLRDRVFSDSVNSPQAICCVPDIAKGGLARIATLFNIVMMFEPREKPCAEVVFGKPGSSEQSEVYELPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF68</accession>
    <name>A0A401GF68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0305290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611722.1">
        <property type="nucleotide sequence ID" value="XM_027755921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF68"/>
    <dbReference type="STRING" id="139825.A0A401GF68"/>
    <dbReference type="GeneID" id="38777726"/>
    <dbReference type="InParanoid" id="A0A401GF68"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="326" mass="36319" checksum="30FFD136BE1FDAAD" modified="2019-05-08" version="1">MPLTAFIARHNVVTIDAYIFLTGSCGSTSTTLVFLYVLWRFPRFIKHVKEEGADPTVVVRLATFYQLNLARVVFRFMFTLPLLVLALDGIIGRRHIVNRNLFWTDFLLMIAGIGCFVSSTITLLIFFPRSIIREAGYKPKPSSTAANSPKSAPITPPALSSPFNAMSSHVQSPLFSPTTSQAAHLTMNMLSPVSWDSELAGPASPGESNFEAEMHQEHELEYDPESAPPYPHLYQRHPFPHSLSSPQVPSAPSSPHEVRVTIPQPVRYAQEPVYVSYRQNVGASEDAVHPMMRSTQSHDYKHAVITFTSPIDLIGIPDEVDYPRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFM2</accession>
    <name>A0A401GFM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0306930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611883.1">
        <property type="nucleotide sequence ID" value="XM_027756082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFM2"/>
    <dbReference type="FunCoup" id="A0A401GFM2">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFM2"/>
    <dbReference type="GeneID" id="38777887"/>
    <dbReference type="InParanoid" id="A0A401GFM2"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="392"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE80970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="519" mass="57763" checksum="DE99CD6A023D3C72" modified="2019-05-08" version="1">MNFDESSTVLVSQEFTAVVLAGFGNELLPLTGNNGDETCPKALLPIANKPMIEYPLAWIEQSGIRDVLLICPAPHRSALSNYIQSDSSTSFPSLRIDLQTYDETQESAVGTCSILRHFSQRIQHDFVLLPCDFVPPDSLPLSQIVNKFRTESTYDGSIATACFYEARRPEKAGSSDEWGVLPSPVSIVWDERTGTLLYIDTPDDVDKNGEEIELRMSLLSQYPRAKLCANMNDSHTYVCRRHVLDALQEKTRLDSIREEFIPWLCKPQYQRTRREKYGSVLSPLSNTSSQGLALRHSTIYTDIHRHHHHYHRGLASPVDPGDGLIRSVAASPVDEAEEATVPSLRVGLLVHRAEQGYAARANTLHAYLELNRHFLAQTTYSLPTDSRSRSLIDQKAQISSDSMIGLFTRVDERTTVKKSVIGQHCVIGKMARIVGCVILDHCVVEDGAKLDGCILGKNTKVEAKAELSRCVTQAGYEVGTGETFKNEKLEVTDWTAETQSSDEDEDKEQEDSPTGDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGK5</accession>
    <name>A0A401GGK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0310440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612230.1">
        <property type="nucleotide sequence ID" value="XM_027756429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGK5"/>
    <dbReference type="GeneID" id="38778234"/>
    <dbReference type="InParanoid" id="A0A401GGK5"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="172"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="338" mass="37782" checksum="D9B16AE18FFEC291" modified="2019-05-08" version="1">MSQASELAALEAAVPKLMGPVVIANALNAMLYGLCFLQFLHYYSMGKRDSLPNQAMVCWTFAVDTTHTAASVWMLWYYLVQNFANAPVIGTLPWPYLSLPIFIILASLPIQQFFAWRIKQLSGSWIVFFALSILSLVSSGVGFANSAVAFTTPSVQDFNSQAHLVDIWLTLSMVCDGFLAGLLFYYLQKSRTGFKRTDSIITRIIHSCVESTALNSIFCMADLIVFNLYTESNYNLLVAMPMGRVYTITLLGMLNSRLAMREELEGELNDTSHAMQPSRIDRRFNISGNHRSTEVKVDVVDERSDVDAYLRSGSRESMKAPTVSDPSYVDHKQQSIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH27</accession>
    <name>A0A401GH27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0312330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612417.1">
        <property type="nucleotide sequence ID" value="XM_027756616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH27"/>
    <dbReference type="GeneID" id="38778421"/>
    <dbReference type="InParanoid" id="A0A401GH27"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="89" mass="9126" checksum="42CA3C4F0235ABC6" modified="2019-05-08" version="1">MQSDPTGSPCGPVGKADEIQYAQRGSNAPLTFRLPSQRYINTTAMKFSLQAIIATATLALTVSGMALPAAETAAVVGFNPMHADATGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH94</accession>
    <name>A0A401GH94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0312680</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612452.1">
        <property type="nucleotide sequence ID" value="XM_027756651.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GH94">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GH94"/>
    <dbReference type="GeneID" id="38778456"/>
    <dbReference type="InParanoid" id="A0A401GH94"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="695"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1233"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1257"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1297"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1349"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1379"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1418"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="300"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="549"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="16">
        <location>
            <begin position="1257"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="164"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE81539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1472" mass="163115" checksum="4365E772523DF4F3" modified="2019-05-08" version="1">MASSSKQDGYDYTEGASAIDIQQALANNARRGRRDSRYGAEGEGAMFDGPSHSVIPSSVSRMSLDGRRSSDAWSRGSRSRRRSEASEASTSAGVAQSPHSRISNDFSYGSVDRVEDHGHENEYSGDEGEDIGLPSRLKRRKSPSPSNPHNRSTVFENIAHIFGRSAPGPVTESPPRSRRLSVASRTSRTRLLRRTSSRRSEASSDYSMERDEDNEERWGYSSGEEDEEALSVESDVGSLLPSGSEHDYGSYPPSPGPSLPLLSSDAIFGAETRIDMVDFENLAPPPPGPPSRQTIYVADEDIDIRMIGYEVIPLRKWIWRLSCVATLGILALLGHWLPRMWLRFVTREKAFVEIKDGFVVVESPYRDIALFPLHRIDYPYDLSTVFSLPLDASARLPVSRTSARSHLQNGDANEKLQSLLVVDYRYARFALDPRTGLFSTVSDWRDSSWTTISSVQNGLEKAVQTQRTTLFGLNVIDIEAKSTGSLLVDEVIHPFYVFQIASIILWSMDDYYYYAFCIALISAISIITTLVETKKTIARMREMSRFMCQVKVFTSGAWTECDSSALVPGDVVNLVDPPLTTLPADMYLLSGDAIVNESMLTGESVPVGKTPIKDEDLARYRDAKDITGDSSKGFLYAGTRVVRVRSNMAPDGSPRIPALGLVARTGFNTTKGALVRSMLFPKPVGFKFYRDSIRFILFLTGIAGLGFCASAVQFVRLGVKWHTILIRALDLITVVVPPALPATLSIGTSFAIGRLRKLGIFCIAPSRVNVAGQINVCCFDKTGTLTEDGLDILGVRALERNVDRFGELLENIHDLPASTEKANFLYALATCHQLRLVDGEFIGDPLDVKMFEFTKWTLEEGDISVKGVVKNRANADRPAALVQVVVRPPGTAQFSLEDALKGAGRRAHFLELGVIRTFEFVSALRRMSVIVKRLKSNSMEVYVKGAPEVMTDICDKDSFPQDYDDLLSYYTKRGYRVIAIAGKSIEGLSWLKAQRLKREQAESGLRFLGLIIFENKLKPGTTPAIQALRSAHFACRMITGDNPLTAVSVARECGLINPAAHVFAPSFLLGNSYTHLSKLEWSDMDEPDWKLDDYSLKPLPSPHHLTEAHELEYQDYALAVSGDVFRWMINHAPLETLQRMLVKAQVFARMSPDEKNEVVERLQGLGYTVLMCGDGANDCSALKAADVGLSLSEAEASVAAPFTSRTPDISCVLEVIKEGRAALVTSFSCFKYMALYSLIQFTTITLLYSFASSLGDFQFLYIDLFIIIPIAVTMGRTLPFPRIHPKRPTASLVSKRVLSSIIGQILITAAVQLWAFVWVRRQDWYTPPARSDPNGDSDQLEASNYENSALFLVSCFQYILVAAVFSIGPPYRKPIWTNALLMFSITALSLFSVLVLLFPPAPIAAVLELMELPFAARLTLLVAVLVNIVLSMAYERWGTAVVTSVIGYFFQLRRRRRVKEGKTYKAVEGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHD2</accession>
    <name>A0A401GHD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0313350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612519.1">
        <property type="nucleotide sequence ID" value="XM_027756718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHD2"/>
    <dbReference type="GeneID" id="38778523"/>
    <dbReference type="InParanoid" id="A0A401GHD2"/>
    <dbReference type="OrthoDB" id="2741479at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="220" mass="24689" checksum="905949B476EDC269" modified="2019-05-08" version="1">MVKEEIPRYDLRTHVCFCRSHQRVGALYGSDDEQEQFAHRACWLAGLGLLPGENPEEVSWRKIAFECVERDGFWSDQPELPVCGGDLLMVNAQNMRSAIDQAGYPVEELSAHPALDYIPEEIHTYRFHADSHRPSLMLIPPNAGILSASAHSIQDQDDQTIKKQSNCTKRRRRRDGVTGGDRSRLIATHTVLARPPRSRATTLVGVPRDVIVKPSPTLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI37</accession>
    <name>A0A401GI37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized mitochondrial hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0402210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612760.1">
        <property type="nucleotide sequence ID" value="XM_027756959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI37"/>
    <dbReference type="FunCoup" id="A0A401GI37">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI37"/>
    <dbReference type="GeneID" id="38778764"/>
    <dbReference type="InParanoid" id="A0A401GI37"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="227" mass="24111" checksum="C376AB27E67FD897" modified="2019-05-08" version="1">MAAASFVQQGKKIVAIGRNYSEHIKELKNDTPGEPMFFLKPTSSYLPSGGNVEIPKGVTAHYEVELGVVVGKGGRDISQADAGSHVAGYALAVDMTARNMQDVVKKKGHPWSAVKGFDTFTPISSYIPKSSVPDPQNLNLTLKVNGLVKQDGNTGSMIFPIPRLIEHVSSIMSLEEGDLILTGTPSGVGPIVPGDQVECAVSDNTGKQLATLTFGVVQRNGGYEFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI97</accession>
    <name>A0A401GI97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0402660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612805.1">
        <property type="nucleotide sequence ID" value="XM_027757004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI97"/>
    <dbReference type="STRING" id="139825.A0A401GI97"/>
    <dbReference type="GeneID" id="38778809"/>
    <dbReference type="InParanoid" id="A0A401GI97"/>
    <dbReference type="OrthoDB" id="5559898at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="732" mass="79937" checksum="639C8EDB632C1A4D" modified="2019-05-08" version="1">MTITALNLSTLKKVKNSVIGNPTAKVALAEDEAFIRMLVDCINNPLPSLEESQGSQDDIRIEAAHVISSLSYGSSSALRALLRFNAHRSFIFAISNFQPSGSLKASYARALRALAAAIAEEVGPSKWGLRSSPSVLREEAKTALDYLFQLEVMDIYLPLLVDPTPQTSTSIAQLIASAVRTQEHRTAVSDWLPPAERIKEVKGKRGWEKAVGPASPSKDGGWVTRNLTTLLLSRDTKFQEAALYALAALAENNPAVATTFAHAPPDREATLAHVLSLCRSRSTELQLAACLCATNISRAGYPNPPLASDNSPALTVMHVINRIIASDNERSRIRTKACFILYNLVSDHKELCKLAFDRGTLSKLACLVKSITPIEQTVEWEEDEPESISCLREAALTAIAAISLFDDDIRGDVTDKLKLIPSIQTSLSHQHVGVRYAACQCVRALSRSVAVLRTNIVDTGLGMAVYQLFQKQDEDRRVTYAASAVICNLANDCSPLRTVLLEQGVVNRLVQLLNSGDSGLRLNALWAIKNLLYKSSLDVKRQVMDGIGWHELAELLTDPDIGVQEQAFHVVRHIAEGADDVDMVFNQLGTEVLLGFLSIAMDSQNEDIVHQAVCVLANLANSPLHQNSILAHSRILGSLKSCLVDAKVGIRRPAIACVLELVRANPHSHQALHEAGIDSTLRHMCEYNGGMGGSPTRRFSIGLQMGAEDDWEVKEKARDALHWLEHNVEMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJF5</accession>
    <name>A0A401GJF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0406800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613209.1">
        <property type="nucleotide sequence ID" value="XM_027757408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJF5"/>
    <dbReference type="GeneID" id="38779213"/>
    <dbReference type="InParanoid" id="A0A401GJF5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="255" mass="27278" checksum="A15406BE58BEE2A7" modified="2019-05-08" version="1">MAPNRLIEDLSAHHNLPAMASDAEPPDTLDITMGESDEEDSIAEPRRPLISDLLDSPGSAQISLPLHSASQTPLAPRHTTPSLVAPFAPSNSPHEHLHRHASPKVQASSGSVAPVEGSRALIPDPLAPAWDESRGSLPIHRRALISDSTPTAPGGMFDFDTPGISPIPRRALLEATPLPPPAHTFDFRTPDTSQLPRRSLIAEPLDATPRTSIHFDSQASTPMARGMLVDETLDAEPVPKLLDFDNSPPATPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJF6</accession>
    <name>A0A401GJF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2OGFeDO JBP1/TET oxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0406750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613204.1">
        <property type="nucleotide sequence ID" value="XM_027757403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJF6"/>
    <dbReference type="GeneID" id="38779208"/>
    <dbReference type="InParanoid" id="A0A401GJF6"/>
    <dbReference type="OrthoDB" id="2744819at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="228" mass="25477" checksum="9FB3E80D84113582" modified="2019-05-08" version="1">MESGRLETSASLKLEGGRSWLHDIHDSSALLGAILAVVHPTLYAAGRQCLGLIQQDPELREMALNWSSPFNALQVIANRETPFHRDSKTRYTFYDLLAMLGNYTCAWLKFPAMRVVIDYSPGTVIAFCGKAIRHGVTRADGERLVYAYFMREGVQNRLGIPAPHWMQASYYASHIGMCTVHHRRDIMPKTDGDENTMQGMETVDGSFIGGTKLVEVMAKCMESQISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJW2</accession>
    <name>A0A401GJW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0408260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613355.1">
        <property type="nucleotide sequence ID" value="XM_027757554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJW2"/>
    <dbReference type="STRING" id="139825.A0A401GJW2"/>
    <dbReference type="GeneID" id="38779359"/>
    <dbReference type="InParanoid" id="A0A401GJW2"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019454719" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="28698" checksum="3997762B1F3DAE36" modified="2019-05-08" version="1">MRAGSRLSFLSTFLAFSFLSYAVAEPGARLSARNHGVGRRRHPVNALQQRDDHLLKRYDNARLTYYSTGSNACGSVDQDSDYVVALNIAQWAGGSMCYQEITITYNGQSTQAKITDECPGCPAGGLDLSPSLFQFFAPESDGAIYGSWNLDSAASPSPSPSPTPSPTPTPTPTPTPTPTPTPTPTPAPTYTPPPSSSSTWSPPPSSSTASSSSSSVSSSSVSSSSSVPPPSSSSAASSSAESAAVPAATAVTYDQGTLSQFNLALVSLAGLMDAAAQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJY5</accession>
    <name>A0A401GJY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0408540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613383.1">
        <property type="nucleotide sequence ID" value="XM_027757582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJY5"/>
    <dbReference type="STRING" id="139825.A0A401GJY5"/>
    <dbReference type="GeneID" id="38779387"/>
    <dbReference type="InParanoid" id="A0A401GJY5"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="225" mass="25478" checksum="56107F0DFE8ED09B" modified="2019-05-08" version="1">MAASEHEAHRVVPPPPAPTMTHHPSRMPSLPTPELISSIAPGAHYAGVLSSGCNDPRQHAQHRRSHNKNSMVEDPAVLGAYKEVMEDLKELFCARPSRDLFERRWRKDAVFEDPLSRCEGYGEYAPQWFAMPKVLSSSEQVSARILSAALSPNRLYYSQTQVYTVRWLGLKKTVTSIVMVELDDDFKITYLADQWNGEDLPTHWGALWLRKLNAKLTSWVVAIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKL3</accession>
    <name>A0A401GKL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613624.1">
        <property type="nucleotide sequence ID" value="XM_027757823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKL3"/>
    <dbReference type="GeneID" id="38779628"/>
    <dbReference type="InParanoid" id="A0A401GKL3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="59" mass="6740" checksum="5A7DFDD1EE7B7D3F" modified="2019-05-08" version="1">MLDAVYTQATKLYPQLVHYEKSWPVRDVLKTKLGNTTYMTKKDRGKEQEARASVAPAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKQ0</accession>
    <name>A0A401GKQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0411330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613661.1">
        <property type="nucleotide sequence ID" value="XM_027757860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKQ0"/>
    <dbReference type="GeneID" id="38779665"/>
    <dbReference type="InParanoid" id="A0A401GKQ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="1">
        <location>
            <begin position="44"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="217" mass="24279" checksum="32FE13D8E45E79AB" modified="2019-05-08" version="1">MERQHFRLQDQPCTADIKVYSGFSKLPPVVVISRTNALFTHCMSVGQHAYVFSPSRKLLELSETEGNEFHLFVAAQTGVSSATYHGVYAAVNTHTQLSVKGWRELYEVPQAEMVDLKCAQVKAGNDSTAGRNGSAQVLCEMVRAKYNKGSLRLDMIVFENKGFDWKFVEAFGKDAAKELIPVKAAAGTTTPPKAHVLCEFPKAMRTPEKNRRKREFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLH2</accession>
    <name>A0A401GLH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613882.1">
        <property type="nucleotide sequence ID" value="XM_027758081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLH2"/>
    <dbReference type="GeneID" id="38779886"/>
    <dbReference type="InParanoid" id="A0A401GLH2"/>
    <dbReference type="OrthoDB" id="2755641at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="149" mass="15551" checksum="D85C41BA4298637F" modified="2019-05-08" version="1">MTHLNDPTTAERAQEHAWHRAIANLQADVEAYKSAGDAAQRAAAASTVALSLRRAGALHPDPSVAHKMAEDADAFERADAGEKERMMHPLLTGLAVLLGTPFALVGAVLVAAGGVVYGVAKTLEGVGRGLAAGPEYLYALWARSRAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLL8</accession>
    <name>A0A401GLL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613988.1">
        <property type="nucleotide sequence ID" value="XM_027758187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLL8"/>
    <dbReference type="GeneID" id="38779992"/>
    <dbReference type="InParanoid" id="A0A401GLL8"/>
    <dbReference type="OrthoDB" id="3248529at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113215" checksum="FDEF2B98AB9D2186" modified="2019-05-08" version="1">MTGSIAPTGAANKDTSTIQPGSGSGGTNLPGSSPLTTAEKKAENLARTARNLLLQQRRDAQEANVPADEPLFHIISRPSTPTSSVPSTTIPAAHNVVGLLSAFSQFSPGSQKKLQTLINTSLPTADNSLPDSVPKLLFSIERERPSSSTSHAQSFGIHPFILNLGQNRVHIPLSLFTTASTNKLHNNSTSIKQNIVYNASGTKCHLIDLTQFQTESEMDVADWHEAWNRCIPFLRTHSDTAVAQRWEEHYQFLSKQDDFKRDFHAILTFDIEQRTRYSIAPEAHNEDAYQRCFEARLTGTPIGVAEHTIRTTVTPVVIRETLPPTNLPFERAREPIPGPLPSASVAAGPATNSLNARKRQRRKESTRSRDISTTNLCSALTRPLSASPSSSIPPSASASSIIPNNTSAPSVAPLNTEPAQENAPNEGDATLLLGARLCPLDDFEEWYPPPNLSAPDEPHVYFNDLQPEPSPFDNDSDFSLILTPYSAPDFQRYLDNAGLLARYPELCFKITHRFLLGDLAPILESFTPDNLPSANDHTEVIREYISEELALGRFTGPFTRAQLETKIGPFRSSPLQVATKVGACGEPDKFRICRHLSYKGTLGQSVNDEIDAKDYPTRWGKATDVAKIISAAPPGTQVATLDIAGAYRTIPVKPDHKRFLVVYFRGFFYMDHNVPFGLASASGLQGEVADATVDIWESLAVSPVVKWVDDFALFRFPCETGPFADGNFHYHYDLTHAKELIAPLRIPWHLTKGQEFADSFDYVGFHWDITLRTVSLSERKRLKYHAHLLLFLQTYENSQVSKKEAQSLICKLSHVTFVHSHGRSYMSNLYAWLRTFNNDFTPRYMRSSVISDLKWWLSTLSIPSAPRSLTGRGPTRDYGIWVDASTSTGIGIIWNGHWAAWRSLEGWKIPGRDIGWLEGIAAEIAILIACAMGIRDANILIRSDNDGIIGAFEKGRSNNAETNLCIRRSEEVFRVTGLSASLIYVNTKDNLADPVSRGIYPADSLRLPLSLDLPAPIAPLFAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLS4</accession>
    <name>A0A401GLS4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2OGFeDO JBP1/TET oxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0502000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614066.1">
        <property type="nucleotide sequence ID" value="XM_027758265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLS4"/>
    <dbReference type="GeneID" id="38780070"/>
    <dbReference type="InParanoid" id="A0A401GLS4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="6">
        <location>
            <begin position="255"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="460" mass="51329" checksum="8F2D1E85DE59D071" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQPPEPAIHLIKMSNLSPMPLTDQIAGVLELMFRQKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELERKWPPPFGESKIRIDQPATLVDMHGHILAWILPRVLIPDRQTKMLQATRALHLAIAASKPSSTTASWRHNPLYFLPPEECAQFPAGSLCLSPGWFQQVREHMESGRLETSASLKLEGGRSWLRDIHDSSALLGAILAVVHPTLYAAGRQYLGLIQQDPELREMVLNWSSPFNALQVIANRETPFHRDSKTRYTFYDLLATLGNYTCTWLKFPAMRVAIDYSPGTVIAFCGKAIHHGVTRADGERLIYAYFMREGVQNRLGILAPHWMQASYYASHIGMCTVHHRRDIMPKTDGDENTMQGMETVDGSFIGRTKLAEVMAKCMESQISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM23</accession>
    <name>A0A401GM23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0503190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614184.1">
        <property type="nucleotide sequence ID" value="XM_027758383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM23"/>
    <dbReference type="STRING" id="139825.A0A401GM23"/>
    <dbReference type="GeneID" id="38780188"/>
    <dbReference type="InParanoid" id="A0A401GM23"/>
    <dbReference type="OrthoDB" id="2789130at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="285" mass="33298" checksum="0B0BE8B9B144BC01" modified="2019-05-08" version="1">MRDPEEIEQILSETAEGDKPEKFEKLGLKLVDPFWRELPHCNIFACITPDILHQLHKGVFKDHLVNWATMCINDMQKDIKNKDQEEEIDRRFKAMTTHPDLCHFKKGISLISQWTGAEYKNMEKVFLGVIMGSVDSAVLHAVRAVLDFIYYAHFEVHTEDSITKLETAWKAFHVNKHVFVDKDIRQDFNIPKAHSAEHYGWSIRSLGTVDGFNTENSERLHIDFAKRAYRATNKKAYLQQMTTWLTCQEAVHKFDAYLQWAELPRLKPQNQNSQNSPSIFVSYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMI8</accession>
    <name>A0A401GMI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614339.1">
        <property type="nucleotide sequence ID" value="XM_027758538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMI8"/>
    <dbReference type="STRING" id="139825.A0A401GMI8"/>
    <dbReference type="GeneID" id="38780343"/>
    <dbReference type="InParanoid" id="A0A401GMI8"/>
    <dbReference type="OrthoDB" id="3269227at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="227" mass="24460" checksum="92B01FDD910D98D6" modified="2019-05-08" version="1">MYKLIRRISSSFFPHPDQSFTDADTSSAPQIGRKRRLSTTEPDEPSSSAKKQKSEPDDASDTASDTTDTPSQPTKETQDVKEVTKGVRDVELEEKAASVSSADDEAAGVPLPDSPVLKATEVSQEVEEEPLEREPLEEDAPSKEPVHTDIDEEDRKENIPPSEQATATEVGKEETLHADVQSDEEEIPGFPSTAGVAAVIEAGKVADEVAVSKRKDSTDALTSKPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN45</accession>
    <name>A0A401GN45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0506880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614546.1">
        <property type="nucleotide sequence ID" value="XM_027758745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN45"/>
    <dbReference type="GeneID" id="38780550"/>
    <dbReference type="InParanoid" id="A0A401GN45"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="17030" checksum="E80AA8BD9AC07F58" modified="2019-05-08" version="1">MTNRAVVFRKFAETGVWSRKCGGGLGDTQGARSLLAAGGGGGHAESLVPRGAAVIAIVDPVAALPGFLVGAVTVGHAGRRIQRPSLTLRGAAARRRGLPCSYHFVSHARECRSCYCLRSHALGVGHACHGVCSDIILPTRDPRPPSSFVLTHEALTRLRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNS9</accession>
    <name>A0A401GNS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0508870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614743.1">
        <property type="nucleotide sequence ID" value="XM_027758942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNS9"/>
    <dbReference type="GeneID" id="38780747"/>
    <dbReference type="InParanoid" id="A0A401GNS9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="8618" checksum="8F52275DBAE40E3E" modified="2019-05-08" version="1">MTEWRANPDYPNHPPPENDEQARKEFYVKCDKFAPRRMGRILFTSGSSLASRITQQYRHSNLKISVGIPKGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPP6</accession>
    <name>A0A401GPP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615085.1">
        <property type="nucleotide sequence ID" value="XM_027759284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPP6"/>
    <dbReference type="GeneID" id="38781089"/>
    <dbReference type="InParanoid" id="A0A401GPP6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10246" checksum="5612F97BBA9BC8D3" modified="2019-05-08" version="1">MAQETCRHTRSLSGCSLCHAVNLFSGSPSATDGYAIERALEAERAASLKPSTPGGQISLDNSPDCEEPVLKDGTLVSNEPLSPNPMSSPPRGVCVSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQG4</accession>
    <name>A0A401GQG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0604600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615394.1">
        <property type="nucleotide sequence ID" value="XM_027759593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQG4"/>
    <dbReference type="GeneID" id="38781398"/>
    <dbReference type="InParanoid" id="A0A401GQG4"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="158" mass="17502" checksum="0E689CCD83E5D032" modified="2019-05-08" version="1">MMSYMITTDPTFLAVMDNEKDMTIQVLTWHFLHGTGCIDAIQPSLTMVELIRPKDPHLIVYRSTNPTPPSFMSNMIQGASSPEKLLSGMTSLLVHFDGGDTPMLVDILSQVHDLACMQNLDIVRAFCKHQAIWDALFALLHRAANGKDSPGNLFTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQP6</accession>
    <name>A0A401GQP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0605260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615460.1">
        <property type="nucleotide sequence ID" value="XM_027759659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQP6"/>
    <dbReference type="STRING" id="139825.A0A401GQP6"/>
    <dbReference type="GeneID" id="38781464"/>
    <dbReference type="InParanoid" id="A0A401GQP6"/>
    <dbReference type="OrthoDB" id="2672960at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="35258" checksum="3F0966A2351D9DFB" modified="2019-05-08" version="1">MQLDPTSLECPDYASDMYAVTRAPLVNDNTSNEQAIQLLVNIWKAGNEADKVAWQLQIEEHEAEIAEQIRLAAEADKDTQEAQLVEQANAQKEETKKNRAKFAPIPDRDVPTVAPVIAANYAVKRMEKGNFVELWYYTNEGLEEALRITSSVDDEAMVITRTADGSTSWVPAASVREARGVTDDKDIHWEDFCQAVLRMVLAMEQARWPEEWITMLARFWGNLQIHELRSSIDPLDQKTLLVYQGEQHKLWHRAITSSATAYNLAQINKELIRKTKERIYWAERGRRDNERDFSVRTSTIWWQMTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR85</accession>
    <name>A0A401GR85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615645.1">
        <property type="nucleotide sequence ID" value="XM_027759844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR85"/>
    <dbReference type="GeneID" id="38781649"/>
    <dbReference type="InParanoid" id="A0A401GR85"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22068" checksum="5D874075CD651518" modified="2019-05-08" version="1">MEDGHHDADNRLQQIEQAEQEAVGDTSDAEGSELTDIETENERPKKKPKKQSTRKAIDAARKQNAKETNKWMKEPVVVESSEDEGTVKREDARAHAGKAGSYKEAKAPAQRDKKDAGNLSGMIKNWATNVPTWNLPFKAHPSSTSGTSQSLAASSKTARTQTSNSTKVSQTVKKLESKSDKINFIEIEVGGGISSDDDNELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRE3</accession>
    <name>A0A401GRE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615699.1">
        <property type="nucleotide sequence ID" value="XM_027759898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRE3"/>
    <dbReference type="GeneID" id="38781703"/>
    <dbReference type="InParanoid" id="A0A401GRE3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="129" mass="14533" checksum="D5BD2AA8F94576B7" modified="2019-05-08" version="1">MTTLSARNCAPRPSAISESFPPPQTRAFVFDLTMFPSSPPPRRPAIPGGYDAREHPPPIQPQCKPIYPRRRNAAHRARIRQHERIMISEPYQRAEDPAVEWPSQLGPAEPVASRPARTPQARRQGARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRE8</accession>
    <name>A0A401GRE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615696.1">
        <property type="nucleotide sequence ID" value="XM_027759895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRE8"/>
    <dbReference type="GeneID" id="38781700"/>
    <dbReference type="InParanoid" id="A0A401GRE8"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7280" checksum="CE9E82323619DD37" modified="2019-05-08" version="1">MGLSDLRNCYTAFETGSSEESNTASRSVKPGPHRFGDRFCMDVGCDSSPKSNAAWASPAEICKYRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRP8</accession>
    <name>A0A401GRP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0701020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615834.1">
        <property type="nucleotide sequence ID" value="XM_027760033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRP8"/>
    <dbReference type="STRING" id="139825.A0A401GRP8"/>
    <dbReference type="GeneID" id="38781838"/>
    <dbReference type="InParanoid" id="A0A401GRP8"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="173"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE84921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="385" mass="40832" checksum="0A860F00F12C0A3C" modified="2019-05-08" version="1">MAVGIASIPGQGPPSSDDADMDVYSEDEEVDQLDSDLDEEEDIPLANGSVSSNRSCTIGRKSGERVPGHSLIPTERVESIMHADGSGGHMSKEAMFMLSVATEEFIKRLAGAGYHEASSERRSVVNYHDVAFATSQRPEFMFLQDTIPTPIPLSEAMQLRAAKEKEILEDNPAISVTPVPLPTTFIPSGPTISHPGGSKPRAPRIRQTNGKEKTNGTATASGTKRQRDSKGRWSLPGQGGEDGESEAGSVGAGASASASGRPSRVRTRPLRISQDESPQAYSAPPNGRAVPQNGTSPNRNHAHGLTAEYAGWAGMPMTPPPAPQPAHASDMADPRLAHPDGRWSPGQYTGPASGYLEDRRVLFGRGGMAGNPGRTIYSAQRPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRZ0</accession>
    <name>A0A401GRZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine thiazole synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thiazole biosynthetic enzyme</fullName>
            <ecNumber evidence="6">2.4.2.60</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0701970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ADP-thiazole synthase]-L-cysteine + glycine + NAD(+) = [ADP-thiazole synthase]-dehydroalanine + ADP-5-ethyl-4-methylthiazole-2-carboxylate + nicotinamide + 3 H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:55708"/>
            <dbReference type="Rhea" id="RHEA-COMP:14264"/>
            <dbReference type="Rhea" id="RHEA-COMP:14265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:90873"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homooctamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">During the catalytic reaction, a sulfide is transferred from Cys-206 to a reaction intermediate, generating a dehydroalanine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.60" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615924.1">
        <property type="nucleotide sequence ID" value="XM_027760123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRZ0"/>
    <dbReference type="FunCoup" id="A0A401GRZ0">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRZ0"/>
    <dbReference type="GeneID" id="38781928"/>
    <dbReference type="InParanoid" id="A0A401GRZ0"/>
    <dbReference type="OrthoDB" id="410463at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160205">
        <property type="term" value="F:cysteine-dependent adenosine diphosphate thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052837">
        <property type="term" value="P:thiazole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03158">
        <property type="entry name" value="THI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027495">
        <property type="entry name" value="Sti35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002922">
        <property type="entry name" value="Thi4_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00292">
        <property type="entry name" value="sulfide-dependent adenosine diphosphate thiazole synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43422:SF3">
        <property type="entry name" value="THIAMINE THIAZOLE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01946">
        <property type="entry name" value="Thi4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="285"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Cys)" evidence="6">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE85011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="320" mass="34338" checksum="9ADE224BEC91679E" modified="2019-05-08" version="1">MAPPAATLSQPGDQPIFLAKKNGTSIDKAYDVLEDYEGNYRFAPIEEAQVSRAMIKRYFNMMYERAVSDVVIIGAGSAGLSCAYHLAKSRPDLKITIIEANVAPGGGAWLGGQLMTPMVVRKPADRFLEEIGVPYEDEGAFVVVKHAALFTSTVLSRVLAMPNVVLMNATAVEDLIVRQDFQGRQRVAGVVTNWTLVSLNHDTQSCMDPNVITAPVVITATGHDGPMGAFSAKRLVSMGLLKELGNMRGLDMNRAEPAIVNGTREVSPGLIMTGMELSEHDGSNRMGPTFGAMMASGIKAAREAIRILESSQIVDGKIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS13</accession>
    <name>A0A401GS13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0701310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615862.1">
        <property type="nucleotide sequence ID" value="XM_027760061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS13"/>
    <dbReference type="FunCoup" id="A0A401GS13">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS13"/>
    <dbReference type="GeneID" id="38781866"/>
    <dbReference type="InParanoid" id="A0A401GS13"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="12288" checksum="7D354C1DD2E2FBD8" modified="2019-05-08" version="1">MSLRRSGLQKEVLALYRRALRMVNTKPPRVRPKFLLFVRYSFKTQASAMSPRDVSAIEHMLRRGRRQLDVYEDSKVRDCWVSEEMLRWSQQDKGQTAGTSRSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSJ8</accession>
    <name>A0A401GSJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0703970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616124.1">
        <property type="nucleotide sequence ID" value="XM_027760323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSJ8"/>
    <dbReference type="GeneID" id="38782128"/>
    <dbReference type="InParanoid" id="A0A401GSJ8"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="94"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE85211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="21606" checksum="039765ADDD6EF1A0" modified="2019-05-08" version="1">MEPSAVASPLQSTSNLPASPPNSDATHPDVRAYDGPDRPPFEVANETASPVPSTADRRRKKKKKRQGGGGADREVPRFPFNLALTLENSGSVARDHLASERTFLAYVRTSVAISSTGVALVQLFTIAEASNQKLEKYSRPLGATFIMIGLFTLALGGARYFEVQGALIRGVYPAIRISVVLVSVALGAVILIVFCIILAVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSS1</accession>
    <name>A0A401GSS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0704440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616170.1">
        <property type="nucleotide sequence ID" value="XM_027760369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSS1"/>
    <dbReference type="STRING" id="139825.A0A401GSS1"/>
    <dbReference type="GeneID" id="38782174"/>
    <dbReference type="InParanoid" id="A0A401GSS1"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21294" checksum="2E68E7DCFE502CEF" modified="2019-05-08" version="1">MSASTPGVATIIQSSAKHPPILTASKITPAVAHMWENACLQYFKHNDVTNDKKVAKVTGSFQDAIISDWYYNDSDTFDTIMWKDFLAAFHSHFLPKGWDSAVLMQLLCARQKEDESFEDWVLSIEKLNTTLHDMISCLDDACLHAQISANICEDLRFTCNEDEVKTIASFKDWKDKLTQLDTVHMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT24</accession>
    <name>A0A401GT24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616304.1">
        <property type="nucleotide sequence ID" value="XM_027760503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT24"/>
    <dbReference type="GeneID" id="38782308"/>
    <dbReference type="InParanoid" id="A0A401GT24"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="262" mass="28242" checksum="062EA4595E6194CB" modified="2019-05-08" version="1">MATTTPPRSLPSANPFTATARTSTFRFYPRRHHYPALQACAQARAQILISLPAETQQPEASALPPPRALAAHGRSPSRNTHRRLPVSRSALTRRAPDAGPRGLARPGALPAQDNGWHARALEEESRDGLPLPQAQDRILPLSESQSSGIHRAPSDTLELEHPTSATPAPFDHLRHAFIHVLGTSSTAEADPGPDPRSAYASAGTYAVLAVPLILPTAPSHLRSNNHASFIRSSPSTSTRTPRVCRVHHAIPYAYGVIHVVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT82</accession>
    <name>A0A401GT82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705660</name>
        <name evidence="3" type="ORF">SCP_0705720</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616292.1">
        <property type="nucleotide sequence ID" value="XM_027760491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT82"/>
    <dbReference type="GeneID" id="38782296"/>
    <dbReference type="InParanoid" id="A0A401GT82"/>
    <dbReference type="OrthoDB" id="3251176at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8809" checksum="50A6F27F7EEFF82B" modified="2019-05-08" version="1">MGGASRKRKRGDYTGSRVNKHSSKRIVTLFGEREPVVEYPSKRSGDICIPQPLQHSVVAHNDTWSDAVLGDTATSRRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTC7</accession>
    <name>A0A401GTC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosylation factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0701790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615907.1">
        <property type="nucleotide sequence ID" value="XM_027760106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTC7"/>
    <dbReference type="STRING" id="139825.A0A401GTC7"/>
    <dbReference type="GeneID" id="38781911"/>
    <dbReference type="InParanoid" id="A0A401GTC7"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001120">
        <property type="entry name" value="ADP-ribosylation factor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019092307" evidence="7">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="20495" checksum="E3DBD6E7A76DB466" modified="2019-05-08" version="1">MVSFFSSFLQWFSGLFFSKTAEISIVGLQASGKTSFVNVIGSGQWSEDVVPTVAFNFRKVRRGNVTLKIWDVAGQPRYRSIWERYCNGVDAVVFVVDSMDREKFDTARFELHQLLAQPSLAGIPLLVLGNKNDLEGHAPVSELIKALQLDKIHNRPVSCYSCSMKSQHNLDVVLQWLARCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTF7</accession>
    <name>A0A401GTF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0800250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616421.1">
        <property type="nucleotide sequence ID" value="XM_027760620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTF7"/>
    <dbReference type="GeneID" id="38782425"/>
    <dbReference type="InParanoid" id="A0A401GTF7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="100" mass="11276" checksum="79146D90A284FFB7" modified="2019-05-08" version="1">MDTSCGSFESVRSVYSDPVRPRRSRRRWVGKYERIAGRSLSVGGGTSPSLLEVRKRQDAGCYARCAPAARTVSEGRQRTAEWRESSHARAYWVLCSRGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTR2</accession>
    <name>A0A401GTR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0801400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616534.1">
        <property type="nucleotide sequence ID" value="XM_027760733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTR2"/>
    <dbReference type="STRING" id="139825.A0A401GTR2"/>
    <dbReference type="GeneID" id="38782538"/>
    <dbReference type="InParanoid" id="A0A401GTR2"/>
    <dbReference type="OrthoDB" id="3892913at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="17294" checksum="6F9762806B5D4823" modified="2019-05-08" version="1">MSSQMPWDVLRAETVRSICRDIGLHATGRREEMITYLKEVERDGLDTVKNKLAEMPAKRKSVGQESRAKRARKAQPAGAAVEEVSAGKRQTRSRRAPSKRAASHSKGIFEGVVLPATSKGRAPSKSTPDPAMQPDVEVGAAGEKADDVDPGEEPADAESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUE4</accession>
    <name>A0A401GUE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0803540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616745.1">
        <property type="nucleotide sequence ID" value="XM_027760944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUE4"/>
    <dbReference type="STRING" id="139825.A0A401GUE4"/>
    <dbReference type="GeneID" id="38782749"/>
    <dbReference type="InParanoid" id="A0A401GUE4"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1055"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="890"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="932"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="987"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1186" mass="130767" checksum="BFDA1F0D199FBEC5" modified="2019-05-08" version="1">MAHPKDKHYWRQLREALTAGKWDISSPGRATNGTQLSWSELLRKFNKHCVGHTDVAELASQTQALSLLLSANSSDHSLDGNDVSGRNPLLLSQECMLPKERIEEATAGYNALKTIESSNLDSIKLAVAYYEYALRRPAECLATLAQAKVPTDVQDYTAPSGTARSKVTNGSVPGATSDSSVSSPWTGSVTTTLSTASVADISDGSSWAVTESIRSICLQGMSYEVISPDDPQTAFNAYLTASSLIGYVASEVPASVPQKAPATPSAGMMSPNTFSRYRELWRWVERLLRRAIILGSYLCDVRQTEQEGGVLWKLFDHYHTCSGHWPPTFRPELRSTIAVLHLRAFVLRYGRLTSPDYSEPASGSDKRHRWISAARSVIQEYRAILSISTQFPRARQRNVRVEDLVDLCVAIWEADGAVGEYAGWVIDVLWWATRLTFNSYRVFRHMSRLLYVSGDSELAKRTLRLYVQVVSKAREAGLGESEHYDTVTLGGDVDTDQNWVQALIHGARMLCRLGLAEEDGSKAVEEAKEAAVMIEKAKTRLDSRDKQLVASLQLAEGIWNTTMANIERDPRTRPSYFEKSLQLLLTSRESFSTPSVHYHLALAYARPGPSQDLQAAIGHARTAVEGDPGSVRHWHLLGLLLTAIGDWKAARGVLDIGAGVGETDLVDDPREAQESAQLHSVDGLHAQDFALSGLNQATLKANGGANGHPPNGHINPSVSHIDNHSITVLAHDATTIPPSATLLQPLPDHPPPSRQESFEHALQLRMTQLTLSEFVEGPEGAGEKWVEVFQWFSERREVGMDDRRMSIDSRRISEEFKAPSEVLSAERLTTPNMGERSLPTIPSSAEGLVDQIPIPSTPIPITVTPASPGITSPLYSAESSTPSQPEPGEELEKHRASGESNHRDMSRGKKVRQVLKSRVSKGQATITTISRKIGHNVGRHGSLHMKRSNSAPDLHAVLSQTPYQASSIHLRQHLSIYASQQDLSLLQPPPPPPPPPPPSQSSTPTTYRQNYRAAKDRRLLSNLWLMSAATFRRLGKIEQARAAIQEAEVRDENNPAVWVQLGLYYMALDNERRALEAFQKALFISPDDISATIHLCRLHLPSTFSQSRPRQNAVESDRDDVDLSVGLLSDLTRGVAWDVPEAWYFLAKHCGLQGRKSLERDCLSFALTLSEARGLRDIGVAVGWCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV16</accession>
    <name>A0A401GV16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616943.1">
        <property type="nucleotide sequence ID" value="XM_027761142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV16"/>
    <dbReference type="GeneID" id="38782947"/>
    <dbReference type="InParanoid" id="A0A401GV16"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="95" mass="10796" checksum="FD0447B217666593" modified="2019-05-08" version="1">MGVCIAPDFSFRARPLMSTGALGLREESSYLPAVHSPVFRTTFVLHVRGITRTRSTLVGFSLVRRQEWLCDALYTMHCARYVSPPRSLRILTNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV65</accession>
    <name>A0A401GV65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0806100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616999.1">
        <property type="nucleotide sequence ID" value="XM_027761198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV65"/>
    <dbReference type="STRING" id="139825.A0A401GV65"/>
    <dbReference type="GeneID" id="38783003"/>
    <dbReference type="InParanoid" id="A0A401GV65"/>
    <dbReference type="OrthoDB" id="2753884at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33944" checksum="8272285EFE366524" modified="2019-05-08" version="1">MAGDRKNDTAIAAEKALCRVGALGSMSTSAARTLSAELLAGIFHLLSVDCGYMEWIRVLEVCRRWRTVGLGVSALWTDIHVAKNLPFVNFCLKNSGDMLVNIFSEEDDAVSDLAGVINSISAIGLRIRSLRWESSDLETLVQSLDFDMPRLTQLALGAESGRRPDKKFFWNPRSDQYPSLCSLSLAAVDIQWSYPPFSSLVNLRLARLTRPDTVDEFLDFLQISPALETLHVDYSAPSVVENLQIMDWVGEEPDIPPPTRTLSLLKLRRLHLGDTTFNVKWLLSHMSIPTGTTLSFTYPLEVGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV75</accession>
    <name>A0A401GV75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617050.1">
        <property type="nucleotide sequence ID" value="XM_027761249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV75"/>
    <dbReference type="GeneID" id="38783054"/>
    <dbReference type="InParanoid" id="A0A401GV75"/>
    <dbReference type="OrthoDB" id="2751422at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44314" checksum="7B18F88688A29387" modified="2019-05-08" version="1">MIVSQLLHDKASIASCALVSRNWNCFVRHRLFETIQVKETADGFCAFMEFLEASPHILPRVRTLGLIGKHPRQTSSLCVHVLACILSRLPNLREASLTDVRIPSHCSCASPWCAEELLVNLEHLHLSRIWFTSPKVVVDFFALFSELDRLSLHHCGWMDVSFAGTWDALMKGLLSRLRLHSLQMDYFFLNTLEHFLCEFLSRTRSTGTLHTATVSFYDYDAVTAFGKLLSDVCPNIRHLRLHLPMENAPNDKETRILSSRLDIRYLLLTKPVHWDIDFDPLALVREILEDVSSTLRSLTLRLRCYTYCDVSSVLAGLEYNMHWGALSEILYQFTELKVLSLEFERDGFWPADLDNDSCRDLVEANIPNFLKQGVFRCSFAKGRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVE6</accession>
    <name>A0A401GVE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617111.1">
        <property type="nucleotide sequence ID" value="XM_027761310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVE6"/>
    <dbReference type="STRING" id="139825.A0A401GVE6"/>
    <dbReference type="GeneID" id="38783115"/>
    <dbReference type="InParanoid" id="A0A401GVE6"/>
    <dbReference type="OrthoDB" id="2752444at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8408" checksum="36D6D952CA3F49C3" modified="2019-05-08" version="1">MSPASESLQSHLNVIPKLAADGSNWITYKERMFTVMGSRGLLRHLQGTARRPPDPPPLPMPSIRKTPLFLKKTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVT1</accession>
    <name>A0A401GVT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0902100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617244.1">
        <property type="nucleotide sequence ID" value="XM_027761443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVT1"/>
    <dbReference type="STRING" id="139825.A0A401GVT1"/>
    <dbReference type="GeneID" id="38783248"/>
    <dbReference type="InParanoid" id="A0A401GVT1"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22647" checksum="C379AE1C27BB2DE3" modified="2019-05-08" version="1">MLAAAQADKTPHWPSLYSLGVELFPISHRAPTHKDGSYLYNANVVFRFTLYWTLVLYTPAFMLCGIYAFLNIVFPPQRLQRASWRRASFTFPFSSPPTAPTSGDIQLQAYDAIPKKDMPSQYRSRTMLNEKRSRLTFGLLVVLTYGVFALTGAVIGSALIGYVLAGIFTAGDYNMSTWMPFLGALLQTLVGYLGLWPSVVDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVV1</accession>
    <name>A0A401GVV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617212.1">
        <property type="nucleotide sequence ID" value="XM_027761411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVV1"/>
    <dbReference type="GeneID" id="38783216"/>
    <dbReference type="InParanoid" id="A0A401GVV1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="177" mass="19805" checksum="45C696014A38DBB2" modified="2019-05-08" version="1">MEDESSVRILAGRVRIRVLCRHRRPQASSLRPRAACARPLPHESSASPTLTRTRAVLIFGAALVFFEFVFLSPFLKPNSCRGECDRTRERRSVRVLRFWHSAARINAVGGACASAGRPLDESRLHATRYALAVLFSESEFVPRATGCRWVRRPSAPPFDNARPNKYHTGMVVYGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVW3</accession>
    <name>A0A401GVW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0902470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617281.1">
        <property type="nucleotide sequence ID" value="XM_027761480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVW3"/>
    <dbReference type="FunCoup" id="A0A401GVW3">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVW3"/>
    <dbReference type="GeneID" id="38783285"/>
    <dbReference type="InParanoid" id="A0A401GVW3"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE86368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="13454" checksum="15F107E3A3AF9C6B" modified="2019-05-08" version="1">MKLVRFLMKLNNETVTVELKNGSVVHGTITGVDMQMNTHLKTVKMTARNRDPTSLDSLSIRGNNIRYFVLPDALPLDTLLVDDAPKPKNRKKDDARGRGRGRGAPDRGRGRGRGRGRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW54</accession>
    <name>A0A401GW54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">37S ribosomal protein S8, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0903370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617371.1">
        <property type="nucleotide sequence ID" value="XM_027761570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW54"/>
    <dbReference type="FunCoup" id="A0A401GW54">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW54"/>
    <dbReference type="GeneID" id="38783375"/>
    <dbReference type="InParanoid" id="A0A401GW54"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="154" mass="17605" checksum="9755285E035AFD0C" modified="2019-05-08" version="1">MVLPHNVCSHLQNAFRARHHRIAVPHTTQNLGILSILLRAGFLMSLTRGTVEEPSPSLFNAVGEPERRIWADLKYRDERPVLSKVELISKPSKSVYMDIGEIRRICSGRRAQMIKPLRLGEIVIVRTKSHEHEWLEAREALELNLGGEIICRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY31</accession>
    <name>A0A401GY31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1003820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618048.1">
        <property type="nucleotide sequence ID" value="XM_027762247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY31"/>
    <dbReference type="STRING" id="139825.A0A401GY31"/>
    <dbReference type="GeneID" id="38784052"/>
    <dbReference type="InParanoid" id="A0A401GY31"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF2">
        <property type="entry name" value="VHS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VHS" evidence="3">
        <location>
            <begin position="214"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="771" mass="85701" checksum="78E02290B625FDCB" modified="2019-05-08" version="1">MKRLFGRDKAKGKPVPGSKDLAAEIAPGAQESYAYVSHPPHNAGRGQSSPLSVDEHWHMVDNDSHTYTVRSAMSGAGYSPSLASTPLLSVPRAVSPVASNPVSPQPMRSPNPRDRDRDPNALKKKGVNGPNAFGAIGILKALDPHPEPPLMPELSEDSLTEASFREEKKERKSFWDRSGLREKEKERGKDRERREEEAHDVLTRMIGYLTASASEDWSLVLEVCERASANEVSAKEAAKALRREFKYAEPAAQLSAARLWAIMLRNSSEIFIWQCTSRKFLDTLEDVITSSRTSPVVRERLLEVLAAAAYASKDSGFRHLWKKVKPADKPDEGIPFDASDAMFQPPPRHHYASHPDQPPQVPPRPPSSGIPHKKISRHHVIPPEEDMRRLFQECKVGRGNAALLSESLTYAKPEDLKSKDIIREFYARCRASQELISAQIPWAFAGAERSRQATGRAEVQHRDLRPSIDSDHPTEESVELTPEEHLLAALLAANEDLMEALRVYDDLERVGLEREIEREAEDRSRKETRIDRSQLRYNEAEDSLYLEPGYPYHGGASSSRSPSPSLSASPSPAPSFVITPMHVSHNQNHPLPALPHHGGSTGGHHQQTAVPAQGSIVSLAPPPPAPMGPRSFTHGSQRSRTPSPEQPAYVARSSLEVRQNGTAHDLNRFLVPDVDPDDERTPKRPSAKALGKRRIIESVEADHHADSDEFYYEHNEDTMRSSEDPLESESDEGHHHPWHQPVNYVYDAAAELTQQRIREGLAAVALVSGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYP6</accession>
    <name>A0A401GYP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1005330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618198.1">
        <property type="nucleotide sequence ID" value="XM_027762397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYP6"/>
    <dbReference type="STRING" id="139825.A0A401GYP6"/>
    <dbReference type="GeneID" id="38784202"/>
    <dbReference type="InParanoid" id="A0A401GYP6"/>
    <dbReference type="OrthoDB" id="3268985at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14029" checksum="8B61B7063C77F896" modified="2019-05-08" version="1">MQPSCSSFVIDDDDADGSEDPEFAESSDDEYEAEDDGSEEEESESEEDEATSGRAGTLSMGDSFAEVRIEGDFDRLVQNIRETRDGSSSGMLGKDWELNIEEKEAEFLNDLRAASGVGRTKKRASVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ45</accession>
    <name>A0A401GZ45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">SCP_1101220</name>
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    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GBE87446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618359.1">
        <property type="nucleotide sequence ID" value="XM_027762558.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="38784363"/>
    <dbReference type="InParanoid" id="A0A401GZ45"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF22675">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH_12"/>
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    </dbReference>
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        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="KH_TYPE_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="167"/>
            <end position="252"/>
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            <begin position="1"/>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE87446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="401" mass="42792" checksum="E32CB84B9DC11575" modified="2019-05-08" version="1">MSSKRKWDQAAPEASDSDTPVKAPKTEEGKSASEAAAAAAAIAAKIAAQFAGAGSGGGTPGQKDPHDGDYIHDIDINDVRNRYLLTKGSTQTQIHEETGASVSTKGTWYPDRSKATEKDPPLYLHISATTQEILDKAIEKVNELIAMDMGSLVEDKKDRLREKRKWPEEKLPVGIDTIRNFNVRAKVVGPSGMFVKYIQQETGTRVQIKGIGSGFVDQDTGHEHDEPMFIHVTGPDEGQVARAKVLTEDLLEVVRAEHTKVKAVLQQQQMELHQAQIQYAAYSAYAGYAPPQPGSAPPPPPPGEQPPPPPPDGSAPAGASPGQAGAAPNASDADAYAAYWAAYGYDVNSPEFKQWQAQQQQQYAQYYAQQGYTGAAPTDDAQAAGGAPPPNDPAPPPPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0S1</accession>
    <name>A0A401H0S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1202490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
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                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0S1"/>
    <dbReference type="GeneID" id="38784938"/>
    <dbReference type="InParanoid" id="A0A401H0S1"/>
    <dbReference type="OrthoDB" id="3262734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="15363" checksum="AD1E99C0BCD11C37" modified="2019-05-08" version="1">MVFVIGGYFLTVEQVATFSAKRGFDNPDGHAYILNRWFRSKGYTAVEAVPVALRHRLPDSTGQAVCGMLIYKSNNDSQRMAYLRDCRPLVPDDGDKEIGAWLERHGINAVWETVPDPYGKFKDDYTWSSKQELVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0T3</accession>
    <name>A0A401H0T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1202260</name>
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    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
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                <person name="Furutani Y."/>
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                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GBE88000.1"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="38784917"/>
    <dbReference type="InParanoid" id="A0A401H0T3"/>
    <dbReference type="Proteomes" id="UP000287166">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="12522" checksum="CEC75C64340A2C8E" modified="2019-05-08" version="1">MQKFMSSGCVYGFLQLRSLLILQDIRPMENIMQHIPGNLSFLTKISSLPQKRVVRQSGLRMHPLGLDPTTAVRPWSHLIKHVGQVVMFCNMLLHHPPPDSSAESLSWQCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0U1</accession>
    <name>A0A401H0U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GBE88022.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0U1"/>
    <dbReference type="GeneID" id="38784939"/>
    <dbReference type="InParanoid" id="A0A401H0U1"/>
    <dbReference type="OrthoDB" id="2804751at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1607"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1641"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1488"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1677"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1696"/>
            <end position="1705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1728" mass="180447" checksum="934C91A6A6484BF2" modified="2019-05-08" version="1">MSVVLEGDGLPAPVLQDTTNAMYVTEVFADKDVVGNTLGKEEMVEEVEPSEGDFKKMAEKVANGVTFLVEEAEELVFDHDEGTAKENGFAHVAHDDSNVSGANGEVEEAAAVEKSQMDVADASVAEEIAEDAVAPSPTIDGEPNQGTNEVAALVVAEEPAPASSGPAEIEVLITEGLSAPSEVVAADEEVFPTSEEAASEPEAVVIEIVEDAPAPEEAPEQTSAPAPTEEVELAVLEPAVEEVRSEEAIVLFEDSTSPAEPTAVVEEAAVEESHPAPVVNESAAAEAPSAEPVVVAGAVEEVPVAEGNTIIEEAVVEEHFAFEPTTEETVDEAPGPESIAVVDEAAVEEASIAEPVTIVEEAAVGEVPAAEPLAVVEEVAVGDTDASEAVTIVEEVVGAAATAIAAVFREEKASVDVPEVTIEDAASTEEEPAVESITIEPPTPLVVAEELRPEEAPQVIPVQEVAVEELAQEVAQEQAEEYVDEVAEQSVEVTEVSVEVPADAAEEVDEEDAAADGEDVPTDASVEDTEVVEEVSTEVPADLDVEIVEEASADPPEAVEDVSVEASSKAVEEDPTEASAEVIEEASAAASAAVVEEAQEVPAEPAEEAMEVTTEHSTEGPVEVISEVVAAVAAASAEIAAEFSSQPSTQSNEVPTVLAAVEPEDSPAPVQEAVAEVAGELDTQDTPVETGGVEASVAEPVIEQKAVEEMVEAVAAIPVDEHWAESRAEVPPESQVLEAAEQIQANAAMPAEELPVAEEVMVETTTEPAAHAEAVSEVVAAAEAATRASAAVEEAIETPAVVEDAEAPVPVEETEAPVVAIQVEQPEIAEAVAEEPAEPEIEASSEALETTKNAENERSTSPWTPSYSVMVQGLGVAGPEGTEEIAELEQTPIAEAVVKAHETEAAVEVPIIQSDGQEEHIAIEAIIGATAAAVAVLVSEPDEMSPPEASAQVVEVPKSPSWVRSYSVSSQGNSPLPSPKVQALQESKLEAVENMPALEHSTEVEVVAEEAAPANKVPAAVEVEEAVAEETAAEASIVPKGEELMPSSDVPITVIIEEAAPMPPVEETKLEPSATAIEVPKSPSWIPSYSVSSHGNSPLLASNVELEEEFTVEVVAEVPVSEPTAEPVVVVEGEESVPVEAVLETAAEAREEVVPFVEVAEVNVDDEASSLSAEAPEIPKSPTWVPSYSVSSQGSSILVEASEVESVPTVEARDEISAVVQEFVEGIEPSILVKVDDTASIASTSLIEEAQGYPRTPTITVAEVDASEPAVVLVVSSEAPEAVDSEEPKSIWVPSYSVSSQGSSPAHAPQATVDRDVENLEPLQTAEEVTKSPWVPSYSVSSQGTSPVPAPQATEDAEVDELEPLQAAEEPPKSPWIPSYSVSSQGATPDVKNLEPLLAPVVDSIASASAEITSSTEEAVVAVVEAQIAVEEEPVVAEESVGVGEPAVVEEQVVVEEPAVVEEQVDIGDRLTLETSAVIAAELERPNSPWTPSYSVNQQGASPLRKDKELNEVEQTPVPAAEPAEDVQIESKPPSIHLDKSAELGMIEAEAAVLVEERPERPWTPSYSVTTQGPDVANGKAHTEKEENFNQAIQSNVSNGHTELQAFPTVENGEPKKMSTKPSLARLVPVNEDEQIEIEASATSVAEPVSPTHARQRLESTTSSRFFPGGWFSSTPKSHDKGRASHETAAGEFSKSPTSATSTPALEVPTNTPTEGIDEKKKGWCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H102</accession>
    <name>A0A401H102_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618995.1">
        <property type="nucleotide sequence ID" value="XM_027763194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H102"/>
    <dbReference type="STRING" id="139825.A0A401H102"/>
    <dbReference type="GeneID" id="38784999"/>
    <dbReference type="InParanoid" id="A0A401H102"/>
    <dbReference type="OrthoDB" id="2747705at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="120" mass="12818" checksum="32109AF8557ACFEC" modified="2019-05-08" version="1">MDQSRPRRTQGGGTLVLGDSVDPAKKCANKKAVCVYGDSHANRKTGASLFSHITSLLENGLITVNGPNRVEVLPNGLARIQDGEARHTNNEASSVKLVVHPQETLQACIGYAVRINRASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H152</accession>
    <name>A0A401H152_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619079.1">
        <property type="nucleotide sequence ID" value="XM_027763278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H152"/>
    <dbReference type="GeneID" id="38785083"/>
    <dbReference type="InParanoid" id="A0A401H152"/>
    <dbReference type="OrthoDB" id="3012326at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="31779" checksum="B5D5D386BAA121E4" modified="2019-05-08" version="1">MQHNNVAVPSVPPRTLFKDLRFSEEEYGRLSAARRSGTFLSSPSTVDEDSPKVRVTGTSDDVKALLNIASGHAQRCWIEVPFSTMDSLLWVMERVEKVIRVPMKYWTLAGDGVMYNPGHLVASLDHFRQPGTIEVVLLPVWEIGRYAEENLKSHTWKHAPVTPPAALPKDPREQAMALFGLIDPVESPDWAAYIKHRQEAEKVTNDLMEGMAGADMDPFVSQLREVVQDVAEAVNPLMDDDWKKIADSVSVIRCVPEDDGWGRLRDVEVLSRIHSLASPQSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1E5</accession>
    <name>A0A401H1E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1300710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619169.1">
        <property type="nucleotide sequence ID" value="XM_027763368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1E5"/>
    <dbReference type="STRING" id="139825.A0A401H1E5"/>
    <dbReference type="GeneID" id="38785173"/>
    <dbReference type="InParanoid" id="A0A401H1E5"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="196"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="779" mass="88506" checksum="7A8A578EDD22D054" modified="2019-05-08" version="1">MSSSRSCAPSPSTLPAEADLSLPPTPHSGTSDWTPLAGEENAEPENPRRSDDDNELHAEKAEGFILGPMPIEEFLDFLPAKHTARRPSTQGAFNDVDEPDGASQLLAAIRDYDRCPGFEFKHNALDLTSVKPALICVPKDSIGSDNEAAAKYAGELFIDVQSGDQGDFFRDPKPFADRARHKFVLSQPDAEKTHRAKARQALGRNVRWATDALMHQHRLHYFSVSIHGLRARLLRWDMSGLVASESFSLREKPEALCEFLWRFAHASTVERGYDPTVERASSGEECLFRQLVSCHVREQLDLKLVDVPEGEVKDEVRAEYEAQCALHEKTVALHYEAGRVAALTICAEDGRLKRCLVSRPIATNFSMRRGAMRGYWAVMEGRVVFLKDTWRQYVHEPEGRILRELEAHKVKNIPHVEHDGDVPKVMYCDGMLTRFSAMANFERTTRSKAGQQPSFQCTETDLHREAEWLCYGGARIVVHPRVHHRLILKEVGFPLQTLRGTKELLNATHDAFQALIAAHDKARRIHRDISAGNIMLYRQPYQDHRIGYLIDWELSSKVQEDGQATDKYIVGTRMFLSQRLEARSQRRHMLQDDMEALLYVVAHCGLHWLQHPAHSKDTRQVVQAMFHNRKEVHAGDVPGVTHTTFQTMEPGKGKLDIKENRTYIDLPNFNADLKDWLSHSMDLNHPRDANAATQWDTPEPWNDYWKEFLDRKLPEDDRIRKQDSSSMRPKSAVKAISHRPGIHPNKRKAPQRRGPTDDGRANDAPANGRPVKRLKRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1E8</accession>
    <name>A0A401H1E8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1300700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619168.1">
        <property type="nucleotide sequence ID" value="XM_027763367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1E8"/>
    <dbReference type="GeneID" id="38785172"/>
    <dbReference type="InParanoid" id="A0A401H1E8"/>
    <dbReference type="OrthoDB" id="2804496at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="339" mass="36800" checksum="4856DB13795C42AD" modified="2019-05-08" version="1">MTLDPKVEPHPMLSLSRAVGNIIVCGAKTTSQGIAKTEVSDRAKMRMQRQKAIEEEQHMEDLEALKLTTDQRRMLLSPFTSVKVEFSDLDGLSWSDPAAQRLLEQWYEARITTSIAPPEELDWGVPLHRCPPKPRFQTPPRTRRSLDVDEESFELIEDTIRVSKVNRPPISIVTELAENDVTGSANDCMDIESLNAAVTPSSAISLTPLPTPVPPTTVEQTACPASLLLPVKSLAPAVDSPAPKKIRLTKRIPAGSRSPNSRRVITLPTRIPQPLARDSVVNTGAGMRVVSAGTRNLPRVADCRALRRGPTLLSARTGAGPPLAAEVTKAAVPASPRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2H0</accession>
    <name>A0A401H2H0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1304000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619496.1">
        <property type="nucleotide sequence ID" value="XM_027763695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2H0"/>
    <dbReference type="GeneID" id="38785500"/>
    <dbReference type="InParanoid" id="A0A401H2H0"/>
    <dbReference type="OrthoDB" id="3198848at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="156" mass="17453" checksum="EBBD0A8F5BE5C3BC" modified="2019-05-08" version="1">MPRTASPSIVTYRLHKKMVYVSPAESYEEAVDFAKAVFADELSGIDRTRVVFSINVAVQHTPRTVQIGPMAWNAVISTLVEYEIIDVSVQSSVCHVGYTDDTPPPYVDTHPKHSWSLSPLPPCRPHTPISPARSPSPGKGTRNWFERHFQPLPFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2M7</accession>
    <name>A0A401H2M7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1400480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619556.1">
        <property type="nucleotide sequence ID" value="XM_027763755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2M7"/>
    <dbReference type="GeneID" id="38785560"/>
    <dbReference type="InParanoid" id="A0A401H2M7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="40232" checksum="5BD95320CBE2A83A" modified="2019-05-08" version="1">MATKRSVRPSSTEVDMAALLQNVQHSPASSDPTVQQLLLALTSSGMITGRKARSDHRSNHLPPLKVKRNIIDVMYDRSEIIEDEALFTDHERDMSDNESADGWDGEGETTTIRFQDPHHEHTYGHTAVTTNDETELYNDFDAELAEEDIPASETVDQLKKSPMLQSTLKKPRATARMTTVVTPLSGSEKLDSILVKFIETAEALRVTSPLSDIARIFETIYSNNTQIMSLVAEAYQHSATAHEKNAEGLFSIMEGAILLNASAKNRCNGSTRQPNQHVVKQKQDAMVNLVKAAFERCYRDTRKNGHTCNECEHFHSQIRDCSQKQAVARDKLAEVSRNCQNFATEKVLYSYGYDQYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2P0</accession>
    <name>A0A401H2P0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-like ubiquitin-conjugating enzyme-binding-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619629.1">
        <property type="nucleotide sequence ID" value="XM_027763828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2P0"/>
    <dbReference type="STRING" id="139825.A0A401H2P0"/>
    <dbReference type="GeneID" id="38785633"/>
    <dbReference type="InParanoid" id="A0A401H2P0"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="116505" checksum="BE493E1687799C81" modified="2019-05-08" version="1">MTTLIRGSSLSTVETAVDEEKHWDPRAKLDANIPKPFPSLEEREQEELLEDLAAEELHFEDADAFPGRAAEGLNAGAATADVKYHPVYDRPASAAAQSPQEDGGSGIRHAEAELMPSIVHVQRSCLATLNDLLSTAANWRPIIPDRRHSMPPCSPVSRTVADQSSSALHTLVLNLRAHEPDATAVHRASLSDADDAALVGELQERVDRLVDSDTLSQHDRALAQTLISLIAHFHRLAALYPRTSVPTSPRVASWNPHTVSPSLSAVHDGPSDPFVHFRRQLSDFQLSRGEGVAMPAVSPVELVETTLLWARVDEELEHVLNLCRARTTEDPQILDTELLPPEYDAAGYDDELDFTIESEGLPEYEVGQWSALDAKTASPSSKANEPETSSPVLGGAGGLSEKMRLDLDAVTLAIDRLYLVAPQLHNQRVELKKAKVEQMERARLEGLSLKRARVREGKQRAVDTTDSQDLERMLELIGRASQRKLVNQAVALEDGLKAKLENARQRDLEKRDAFVAQLVHHSAVGRLHSQDAVFPTSNGRRKEKDPEALLSLPEFMREAVPEPSRLRMQMADSHALLSLPEFMKEPTHSALEPLTPPPCNKSSKGYRSRSLSAPPLSWLLASSSRPSSPGQLSESKRTKAAGKMRRVGSSVSRMPALQTGLDVHYVAEYHESLQHILIFLTVYGSEPDVPLEAEVVPLSDVPGFERECLCLRSGASTSPYLSLPARVHPGKKEVQEIGGHYQIKLAAAPSTPTGTPTSSAYPSMHAALLDADQLSELTPTGFVCASCSLPLVHCSQVSKFKDLPSEHWAELVDAWMCHSDQKLHENVTRHSNEGFWPTKGLAFVGGSYILFDESAVVKSNFWPSSQETKSTDDWQRVHCICGAVIGRCQDHQPKDAPCSIVYRLAKYAVRPTNPAAEPARVPLSAFIAEDMNEFVQAHATYRFVILDEEDERPRILMWLFKPNMRLAYITPAQYVIPKSGSIHAAKVLYKVLKPSIAFSDLPALTNKYPGFPQAEHLYYPIDICRRLGNLLKESTTAYPESLRTMTGLSVGWLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3X3</accession>
    <name>A0A401H3X3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1501060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620016.1">
        <property type="nucleotide sequence ID" value="XM_027764215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3X3"/>
    <dbReference type="STRING" id="139825.A0A401H3X3"/>
    <dbReference type="GeneID" id="38786020"/>
    <dbReference type="InParanoid" id="A0A401H3X3"/>
    <dbReference type="OrthoDB" id="3271031at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="146" mass="17268" checksum="DE6ECFD0121441C0" modified="2019-05-08" version="1">MQHGNIREYKVVLHQNQQRTIIDFDRSERHECLYPRLILFDVAEPSRNKFGCIEFYQICLDCDVWTPNMVRYFSGYVHVRYSESPALLASVTPVDVPNKEALKHAHMVVEQYKRIYGKWADRNPIPWYVDEEDPLHSSRACHKNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4I1</accession>
    <name>A0A401H4I1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1502970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620202.1">
        <property type="nucleotide sequence ID" value="XM_027764401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4I1"/>
    <dbReference type="STRING" id="139825.A0A401H4I1"/>
    <dbReference type="GeneID" id="38786206"/>
    <dbReference type="InParanoid" id="A0A401H4I1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="61"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="461" mass="50060" checksum="3A32B990DE603F57" modified="2019-05-08" version="1">MPSTRIFTGRNVYLGGDRLQSATIIVDIPSGKITDVHTGIHGRSSLPAHQDAEWVEAGDHYVLPGLVDAHVHLNEPGRTDWEGFWTGTRAAASGGVTTVVDMPLNSIPPTTTVAHLEDKRAAARGQCWTDVAFWGGVIPGNQAHLRPLIDAGVKGFKCFLIESGVDEFPCVAESDVVHAMEELKDTSTVLCFHAELDMSPSRSSNTSWPQPDPTLYDSFLSSRPDQLELDAIKLITALHARYPSLRLHIVHLSAASALPLIRAAKASGLPLTVETCFHYLCLAAADIPAGRPEFKCCPPVRDATNREELWGALLDGTLDCVVSDHSPCVAPLKCLDDGDIMRAWGGISTLGLGLSLLWTEGRRRGVSIGQVVSWVCEKTALHAGLQDRKGRFAVGFDADIIIWDSEAEFTVTKEALNFKNKLTPYEGLNLRGLVEKTFVRGQLVYDAAKGFKGLEPIGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H538</accession>
    <name>A0A401H538_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1601510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620402.1">
        <property type="nucleotide sequence ID" value="XM_027764601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H538"/>
    <dbReference type="STRING" id="139825.A0A401H538"/>
    <dbReference type="GeneID" id="38786406"/>
    <dbReference type="InParanoid" id="A0A401H538"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE89489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7682" checksum="DE2BC22E504B27E9" modified="2019-05-08" version="1">MLLLPDVQGKAQQELDQVVGSGRLPDFEDRGKLPFVECVLQETIRWYPIAPLGRESPMGTRMLLTLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5B4</accession>
    <name>A0A401H5B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1602460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620496.1">
        <property type="nucleotide sequence ID" value="XM_027764695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5B4"/>
    <dbReference type="STRING" id="139825.A0A401H5B4"/>
    <dbReference type="GeneID" id="38786500"/>
    <dbReference type="InParanoid" id="A0A401H5B4"/>
    <dbReference type="OrthoDB" id="2684236at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="ENOLASE (DUF1399)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365:SF7">
        <property type="entry name" value="GLYCINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07173">
        <property type="entry name" value="GRDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="730" mass="80687" checksum="4489CD1CF502F99F" modified="2019-05-08" version="1">MADKGLPSYANVNADPSVYLDAPPAYTESSPNVQVTPSTNTGSSTNATPSADTVRVPASTNATLSAETVLPTRVAASASTSPSTTNTLPASTAVSSNIATPPKPAASRNAASSASSASFTTATASTNTRSTYIGPSAYHIGDATLHAPLVELDHLRAHLALLRAFKALRTLIEDADELGLQALRMDSTARWAWFVGLAVERFQRWTAVVRKGDLLTWVAAELPPIDVLMVWHAYLLNPGWYAEDCLRLPIMETLRTLGDRFIHAVFEMGDPEQYQPSPERVASWQEQTGTPWDALDAAVQMTHQRVECPRCCMFNEAPYLTLSGTGYAQHKFAHYCMRCGFEVTRETLAVRRFVRDLTKPYLDSQDSDSRYGAYLAGTLHTETKAKNTSRGEAIRGILMRSRWFRKWDGFVSSNDWEEGLLKKLQYSLSAARAAADDAMQPNGGSLCRRIFSAYTDDRPFSIDLVGAVVRQGAFIDKMHEFGWTKPGYFDSGEDELVLVHATARYHAFLDLMNTSPSLSLLPTLDIDLVWHSHQLMGSRYEKDCMQYVRRYVDHDDTVKENKLAMSLETTCRAWQGRFNIPYMYCGCPLPGESVGQRLTRLSQNLFHKNDSDASAILSPPRRADAFSATHASEHNSVVPSRGAHAAAAEQQRHGRAERFTRRQRRDAERALAGRIDVDVFELGRTHDAAFLTPMPFYRPVAACVVVANPIDTEKLGIYPGELVFSEHGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5G6</accession>
    <name>A0A401H5G6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1602630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620513.1">
        <property type="nucleotide sequence ID" value="XM_027764712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5G6"/>
    <dbReference type="STRING" id="139825.A0A401H5G6"/>
    <dbReference type="GeneID" id="38786517"/>
    <dbReference type="InParanoid" id="A0A401H5G6"/>
    <dbReference type="OrthoDB" id="2663142at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019318450" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="57474" checksum="66FDD5CDD564C98B" modified="2019-05-08" version="1">MHAALLIDEILQVILGQCSDWPDQEYRRVLCQIAKCCRAWKDPALDRLWNRLDNIEPLLRLLPMQLLRRNASLNYNVHVDNLANFRTYASRVRHVTHRGALPVSPLLQSIILMPKLSHVVLRGEGCEVAPCFKTSRALRHLNITLNHYNKERPHSMLLRSDAVATYLDSLNAWDVDLQTLRLRGRLSAQLSMTLASLTTLRTLLLYAGDSLTAQMLLAIANFPRLRRLDVQATHINPSTFFETLSPSAPPLFPTLQNLKISCQPDFLAALLQTLPVGVLQKVQIDTAYSPISFHPSFERLSLIGSHSLEELCVEAFIPSDDVEYSGAVHSDRALTISALRPLAGLKALRRFSIHGTAPPDFCDGDIEQIAAWWPRLSLLNLGLIEDFHADAFSRLTPAVFFVLAKLCRELKSLTLPVDILDSALPLPPPGAHLAISLCSLRSLSIGTAPLSLDCISVFVRHVVAAFPGVENVDSTSWGGYWLEHAEECIDLRPGAVGPLSDRIVVGDRRYRFVTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5H2</accession>
    <name>A0A401H5H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1603260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620575.1">
        <property type="nucleotide sequence ID" value="XM_027764774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5H2"/>
    <dbReference type="GeneID" id="38786579"/>
    <dbReference type="InParanoid" id="A0A401H5H2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="131" mass="14063" checksum="4E501FF1AEEA305E" modified="2019-05-08" version="1">MARSHEHVTSTVRKTTTILPAFSTPRFGKSKTPPLALPSNGDHLYISISSTDTTPPSASVSSVPSKRPSLDAHIDQEHTGPTKRPRIDTAPGKENGFISDVKGKARELPLNRTLDFHAPGPINPSPIKHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5P7</accession>
    <name>A0A401H5P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1700900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620678.1">
        <property type="nucleotide sequence ID" value="XM_027764877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5P7"/>
    <dbReference type="GeneID" id="38786682"/>
    <dbReference type="InParanoid" id="A0A401H5P7"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="465" mass="52478" checksum="207CB16F3D3D4654" modified="2019-05-08" version="1">MVYVPPEIRDMIIDYLWYDSAALQKCCLMCRAWLPRSRLHSFHTIVIAGDNQYARFERVIEASPALCDYVRCVTFKGFDSWYPGGGLFNVLRMLSRVEEVALQDCEYVEALVDWDGDISSYFPMVRSFRLLKGEILGSSWAVGLSRVYDGYRIRRILAECPKLRAVHFAGVQLSHPTAGVGPLDAAPEGNTGASRQLDIHDLTLSYDPTQITPGVPPPLSWLFAPPLKLQLQNLALMWCEKSSLTPLGITDQELLCNSKDSLEELTLLCPETAFHPFEMPSPPQMFLDLAQNSRLTSLKLIVPWITGFDPGPEIARWIKAFHSQLAINSASLTRLTRVEIELKIEYPSVKDRALFQPVGYCSDWVPIDSQLAALAVDCNTGCGAKRRIEVVFKVNLVHHDILDVSSSYIRKWIAARLQLFCDCPSSRLDVIYSIQASLKARYQQHYLNVLYPPGLSLISLYHLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5U3</accession>
    <name>A0A401H5U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ZZ-type zinc finger-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1701070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620695.1">
        <property type="nucleotide sequence ID" value="XM_027764894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5U3"/>
    <dbReference type="STRING" id="139825.A0A401H5U3"/>
    <dbReference type="GeneID" id="38786699"/>
    <dbReference type="InParanoid" id="A0A401H5U3"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="317"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="322"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="387" mass="43057" checksum="839A3C224175A3C9" modified="2019-05-08" version="1">MEEKRAKTLDALSTFIQSQRDLLAQTQSDITRLRELRDEVAEAPPDSLDDVGDKLKASSTRLSGQLDYMPPLPDDIDWSLFKGCDPTPLKELAVGCRQAYAQRNEPPAIQHSELSELQKLVKDARVHMVDPVLAAYSYLAEMSEDEEEEVDPEVCRSAREREKIRELKKRRLDDTSVPGFGGLRRPRANGVFVRRDQADESAEVDISCNAYGDGDAEGDPSMLGSGSEVVPMDVDTPPTSVTSPLSAVSGLPPSHPPVHGKPVRERRQTRKAKEAAPPADVRAKPKGRRETAPKSADLPPEPASSSAAPQKEKSKQKSETYKQAWSVSEQHLLERLLEEIPEGEKNRWLKISQAMNSRRTARQVASRVQKYFEKLKRFGLDVGKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5Z1</accession>
    <name>A0A401H5Z1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1701830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620770.1">
        <property type="nucleotide sequence ID" value="XM_027764969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5Z1"/>
    <dbReference type="STRING" id="139825.A0A401H5Z1"/>
    <dbReference type="GeneID" id="38786774"/>
    <dbReference type="InParanoid" id="A0A401H5Z1"/>
    <dbReference type="OrthoDB" id="2678860at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="615" mass="66902" checksum="8E1D9A4C498B94C6" modified="2019-05-08" version="1">MASPTWANNEELDWLTERLPRFLDHQKRKKVQSFFRTLYTEWDARYPECTHLFLDIELMAQLTPEQEVELTEAISLRQRVHYVLCIAGTNLMGIQQLNNWYNNRKPKGHSADKSVILKDFIPKDADHVKHLPQAVEVYSHLYYKEKVKVDIDAEIKEKDIKNGKVVTVVRHLTQKRYEAETPEVHAEIAAEVKWMKAQHEAEKAQTEEVHAHGEFSPAEYQRMLYNMPATFDQFLGAMVKATDGGNLWSMVFHSAEGSNDVKFSNTVPEFEAHFIEPFGQFLTIAFPMATSREVTPITLDDIRYQIEDNSDTEDRIPCVEASSLSGTMENVAHTPVTTTESGITAKLSTSSEAMRTLTTISYTHLSLSASQPSVQSSPAHASSIPSSSRDQLSASANTALAWVPNPGVWQFDPPEPAFKLEPNLQPMSLDSAMLGTVLDRMGSVSQMTGLGSQKLAYALSGPSGSYSATSDVAHPEVVSSGASSSPSFAAQSSSSPTEAASSVSPAESLSRSFPATRSSSRSATPAVTSATTPPLLVSSAHPSSLPSHQELNSTVESADIAPPSITVASANVDTGPACKHHQGQRHAVPVILAATETVNAGREDGALAAKSGRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H600</accession>
    <name>A0A401H600_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1701690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620757.1">
        <property type="nucleotide sequence ID" value="XM_027764956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H600"/>
    <dbReference type="GeneID" id="38786761"/>
    <dbReference type="InParanoid" id="A0A401H600"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8105" checksum="227D811B1F5B5921" modified="2019-05-08" version="1">MVLAAASSKEELEVNKIAGGKDFALFSVLLTPSLVGWLVLEEGHSTDVPVYVGKSAGGPDDAAVRPLHGTSRSPQAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H622</accession>
    <name>A0A401H622_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620787.1">
        <property type="nucleotide sequence ID" value="XM_027764986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H622"/>
    <dbReference type="GeneID" id="38786791"/>
    <dbReference type="InParanoid" id="A0A401H622"/>
    <dbReference type="OrthoDB" id="10627491at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF7">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24107" checksum="05BCEDDADD9FEDA8" modified="2019-05-08" version="1">MSTSADNTSNSNAYRIPLLKEDNWLPWKRCVEAILNDKGLQEYVTGKTPKPQPSNDPANRAAREAEISAWGEKDLKAQNVIVLSLGDSQMVHIAGAETARAMWEQLRTVKEQRGQHGILALCRRFYRMQAKEEDNISSHITQLRQIQEQLHLMGKVVSDEDFWLILATSLPESWDSFLSSYFGAVGGNVGAEGADNVRPQLTSQELIAIILDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6Z9</accession>
    <name>A0A401H6Z9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1900430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621107.1">
        <property type="nucleotide sequence ID" value="XM_027765306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6Z9"/>
    <dbReference type="STRING" id="139825.A0A401H6Z9"/>
    <dbReference type="GeneID" id="38787111"/>
    <dbReference type="InParanoid" id="A0A401H6Z9"/>
    <dbReference type="OrthoDB" id="3352270at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="572" mass="62962" checksum="7468ACADEF8B091F" modified="2019-05-08" version="1">MHASESLASKVCAPAHPRIFNLSSRVAHSMAHAGVYALPVELLARIFELGREDAPSPDLQPPGEPTFEVLVSHVCQHWRDVALRTPTLWTLVHFRTTPHLARARAYLSRSGSQPLQIFVDTCAKDEYVPGWLLFRDEFHPVFDTVVPHIARWRSLYLKVRDLACKRSARDVLSTCGAAPRLASLTLWHIEDWGTSERLYTAIGPPPVVVFAGRLPALRHVHLIGVNLPWSHSPFLRGLASLELALHSDDVRIPFDRWHAMLAASPALERLSLTYSGPRAAAPPWGPPARVRLPRLRELRLTDLDPPYLCALVRTLDAPALRTLHLELSDQDFTPFVRMLARPPPPSDGPLDPSLPYDDQGEEQDEEHEEHDEEGHADDEEGEGRGGEEKGEEGHGGRGPLFPALETLSIAALECTLPSLRALLAGAPRVRHLDAAFARMPPGALELLARDDDDDGGGVEGAGVQVEGAGEGAGEEGRGRAGAGRRRGPLLLPALTTARLAGVDGAALRRLMRARGRAVRTWYVHERWWDEECERLMVECERAGAARVEWFEGEEGEEGGREEGGEEEGQEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Z5</accession>
    <name>A0A401G4Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial oxaloacetate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0101040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608145.1">
        <property type="nucleotide sequence ID" value="XM_027752344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Z5"/>
    <dbReference type="FunCoup" id="A0A401G4Z5">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G4Z5"/>
    <dbReference type="GeneID" id="38774149"/>
    <dbReference type="InParanoid" id="A0A401G4Z5"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="217"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="323" mass="35292" checksum="BACB414A0427ECE9" modified="2019-05-08" version="1">MASQKAHGRPLSTAEGFVLGGMAACVAVTFSNPPDVAKTRLQLQGELAKDGGIKVYKNTLDVVLKTWQHEGIRGVQRGLAPAYVYQILLNGSRLGFYEPIRYWTNVSLGISPSHQVPFTSVFAGAVSGAIGASLGSPLFLVKARMQAYSPALPVGAQHYYKSSWDALATIFRVEGVRGLWRGIDAAILRTSMGSSVQLPTYNWTKNHLVQSGIMPADSVWTFLLSSTVSGVCVLAAMQPADTALTRMYNQPTKLLPDGRHVGVLYKNPIDCLWKTLKTEGPLGWYKGSVAHFFRIAPHTIITLTANDIIIKFYRRLRDGDLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G510</accession>
    <name>A0A401G510_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0101180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608158.1">
        <property type="nucleotide sequence ID" value="XM_027752357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G510"/>
    <dbReference type="FunCoup" id="A0A401G510">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G510"/>
    <dbReference type="GeneID" id="38774162"/>
    <dbReference type="InParanoid" id="A0A401G510"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="17"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="345" mass="37121" checksum="4A159BBAD7464D20" modified="2019-05-08" version="1">MSDFPKTIRSIAIDKNGDIDVLQVKTVPFPAAAPGDVIVKVAYAGVNFIDTYHRKGIYPIKSFPQTLGMEASGTIVGLPTDEKVLADEQYKKRGFKVGDKVALLQFGVHGEYASVPWAKVYSVPESVSLKTAAAALLQGLTALTFVTEAYNVKKGDYVFIHTIAGGLGLIFSQLAKQRGAIVIGTTSTPEKAAVAKAHGADHVILYPTENTVERVLEITNGEGVHVVYDGVGKDTFLNDFKLARRKATIVVVGAASGPVEPIPPLKLVEKNLALLRPTLMNYTYTPEEALHYGSELFSLIATGVVKINIFKEYPFTTEGVQEAQTDLTTRSGKTIGKLVIKIAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G529</accession>
    <name>A0A401G529_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquitin-60S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0101370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608177.1">
        <property type="nucleotide sequence ID" value="XM_027752376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G529"/>
    <dbReference type="FunCoup" id="A0A401G529">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G529"/>
    <dbReference type="GeneID" id="38774181"/>
    <dbReference type="InParanoid" id="A0A401G529"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE77264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14509" checksum="4FD926B6E4238B77" modified="2019-05-08" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKVLASKYNCDKQICRKCYARLPPRATNCRKRGCGHSSQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5L6</accession>
    <name>A0A401G5L6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0103180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608356.1">
        <property type="nucleotide sequence ID" value="XM_027752555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5L6"/>
    <dbReference type="STRING" id="139825.A0A401G5L6"/>
    <dbReference type="GeneID" id="38774360"/>
    <dbReference type="InParanoid" id="A0A401G5L6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="52012" checksum="D40D4D60BA4270E3" modified="2019-05-08" version="1">MAGRIDAQQSESELTFKFRIENLHALFTLPEGQKEGPALKTDEFGPGLSFKLQVKQKEDEQPALGVFLVIPESLNTPAARINCKLTAHSLDFRTTYFSRTWEHVMRSGGSGRGWPTFLTFPFVQKTQEEALWIRAVVKVSMGEPSVRSNATLTLLHKVMHSREVDALRFVSYEARGASGKLGRPRSTFAPADILTESCENVDSLDKFMEILHGFALDEEGYPANLHDTAASYTGYDSDSDDFDDDDSDGAAIDGRGTKRKFDAIADAKSEDSDGNVEMVDETTVATVKREPFEGKVIVLQDAAARTWEALLFYLQTGFIVFAPLSSSDKQARDNFREKYRDLHPNRPESPSCKSIYRLADKLGLDDLKKRALLHLESQLSPQNILDEIFSEFTSHYEEVRKIELAAVVKWWAQVQKQPALITKMEEVASGKLPHAGKIMIEIWSRVMVKPEDVAKAAAADLPSNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5Z5</accession>
    <name>A0A401G5Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608505.1">
        <property type="nucleotide sequence ID" value="XM_027752704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5Z5"/>
    <dbReference type="GeneID" id="38774509"/>
    <dbReference type="InParanoid" id="A0A401G5Z5"/>
    <dbReference type="OrthoDB" id="3363533at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="206" mass="23641" checksum="3091CF8669B54011" modified="2019-05-08" version="1">MRRAQSVRHYARPSLALGADDLGMLKESPDESIEDVLRRQLLEKDRENDKLQTQIQTLQAQLAQRPPLEAVQAMQKEHTNLEILLQGTQRENERCMAELERERTRQKMLERELERLAGANWQANLDITSSSAVPTRHRSGTQSSIFAQAQASKQEASTTQIEQVRLLILGMEQRLQSREEKLLQTVEHAEAEGSRFEEMRKQALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6D1</accession>
    <name>A0A401G6D1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Transposon Tf2-9 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SCP_0106000</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608631.1">
        <property type="nucleotide sequence ID" value="XM_027752830.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G6D1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6D1"/>
    <dbReference type="GeneID" id="38774635"/>
    <dbReference type="InParanoid" id="A0A401G6D1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="20">
        <location>
            <begin position="626"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="1180"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="19">
        <location>
            <begin position="1479"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GBE77718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1533" mass="176083" checksum="ED9657DD477607A3" modified="2019-05-08" version="1">MDEGRHHASQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDPNAMDVDCVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLDGTPNQMGTITHCTWKMMKIGGRKTLTRFLLTGIGKENILLGMPWLKRLNPMINWETGDFWFGKEAKWPPKPTVEDAPDKEVSIFKEDGLPELITTETSPTSFGHSESIREIMTDNTERGELPAVRNDTELDDLPSESSMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGTFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVRTRRILQRLKDNDLFLKPEKCFFDVKEVEFLDMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGELHPCAYISQTLNPAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQNLNCRQAQWSLKLSQFDLHLIHVPGTQMIQSDALSRRNGLDDSESDNEDRILLPNALFVRSISPTLFDEIRNHAAKDLVVHEALEAIAHKGPFPMKSSLSDWEVRDGVILYKGKIYVPPSETLRRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLRLYCGNNPETWADRLPDLEFCHNTREHSARKMSPFRIMMGYEPRGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYVNPPPDVVDNEEEYEVEAILNHKTYRGHLRYLVKWKGYSSAENSWEPTHNLQNAKRILDAYKRTRGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6E9</accession>
    <name>A0A401G6E9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0106240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608655.1">
        <property type="nucleotide sequence ID" value="XM_027752854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6E9"/>
    <dbReference type="STRING" id="139825.A0A401G6E9"/>
    <dbReference type="GeneID" id="38774659"/>
    <dbReference type="InParanoid" id="A0A401G6E9"/>
    <dbReference type="OrthoDB" id="2754405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="498" mass="55508" checksum="0C590E44F3996DB1" modified="2019-05-08" version="1">MNSRSAFLRNLAMNGSRTSTYTWNFLLATAGVVAAQSGSDARSFAAAVQNINGMSSIFSLIPVLTGKVQNIKLIAVGMLLFSCELYRNVVGEFSYHHNEYVNVFSPSLIHIPTGTPERHASNVIINHNPSEDYMVEAWFQTQGRPAQVELYQTGNERTFLGMLAYMLIYSVETFLGVRTAATGTGIVLIGMQAAAALSWICAICVLQRCRGQGKRFIELNRLGSSEYRCFKLVTQGHNVHSAVFSIHLNNLQEFNIFRSEYQTRSLKFVGAAILVSAVIDALATILLVGLNSWAYGWLGYQSVILFAKVVFSLEPLREISIKRVWPMVNCSHPLQPERASRLRNVRLPMTVNSAPEFTFLEVCIGKNIVVEQATKRRWQSCTPGLYIGQPYFSGEKECASSLSVSIVRYLALSEGKLTLTVDEPAKEKNQALQREFLACLAEVTKANKVPSLEFVLAVETTMRGVRQTMDAQWFAFGTKDLVQYLETCKTAIIWRSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6F3</accession>
    <name>A0A401G6F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0106270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608658.1">
        <property type="nucleotide sequence ID" value="XM_027752857.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6F3"/>
    <dbReference type="GeneID" id="38774662"/>
    <dbReference type="InParanoid" id="A0A401G6F3"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="485"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1165"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="735"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1325" mass="145763" checksum="37BAF6A52346C448" modified="2019-05-08" version="1">MASPLSTSSPTTLPPIRSFAQSDPIDLTQDDDDEDEDGTSSYVNDRKCKRMCTSSRSFDASCSTPSLLDASSCSKPYHSGLSPAMSSSSLHPGSAGPSASSSAQWGPPRSTPDYTHAIANTIRPPPFTGPSTSSAFFQPRPSTTPLPPVLAPLPARVYSETPSNSSARHVIDLTSSPSPPPGAPLPPIPQPTLGNLPPDLGVKTPVCIGQLTVTALVLYPIPYLEPQPPVLPDSEWAPVRLSYEHNPNKVSGQETIHIKTPSMKTHTGEILPGENFGVVEQKIATHLGPMYGRGLIRLDAKVRRGIKLPILPLQLLVFTPKGNIQVVADWLHRHGLFLDHPTLSSDKARLANQYYYNPHNPPPGGHARALIGPSGRLGYLGPGGSSVGRWNAGSVSGKSVEVQRSQVDELFKSLRDGEELEETEPAPDVATKLYPHQKKALTFLLERERERVGPSGTFSSLWQERQDPMSGQPVWFHIVTQRETRHEPQEAKGAILADDMGLGKTITCVSLIAATVESAHEFSASPLCTLPPRPPPQPESSLSAAHFAGSVWGMPDLLPESSSKRSKAKVAREQDRREAEYMRASRIKVKSRATLVICPLSTVVNWEDQFREHWRGEVTIVGGNCTAVATPQSGMISTPTGSTPQLSRHDSFQLDIKSFMGRVREGTPVRIYVYHGNARRPDATFLADFDVVITTYSTLASEFSKQMRSIASADDDDDDDGSSDGNLDLDDVKPPKSKKAGAKKRKKPCTALNGVEATSPLQSVHWFRVVLDEAHSIKETSTVACRACCDLIADRRLCLTGTPVQNKLDDVFALIKFLRLSPLDDKNVWTEFIGTPVKYGQPLGVARIQTIMKCITLRRTKESKADDGGRILSLPPRRDELRYLKFDEQEQAIYDQFFQESKEEFHELSHKNEVMKNYVGILQKILRLRQICDHFELVKDKGLGLIGDTQTQDSGTSYEDIVAVVAREGINVQRAATIFALLRESSLTQCVECGYELAAQLDVMAGEGSVAESDTPSATPKRGRKAKAPASRSSTRQNSPSTPTPHAVLTRCQHLFCLECFRNSVYPGWPNVSADLRRCCATCQTALSPLDAVEVGCDQADMICKKKSARREKRTKGISLENFHPSTKVKALMSDLVQFSKYNPYSANYDPSSIEVQMVDDRGNNLDDGVVKTVVFSQWTTMLDKVEDALEVAGIRYDRLDGTMKRDERTRAMEALKHDPGCEVLLVSLKAGGVGLNLTAAQRVYLMDPYWNPAVENQAVDRIHRLGQTRPVTTVKLIIENSIEARLLEVQRKKTELANMTLGQNFTKAEMLQRRMEELNQLFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6H3</accession>
    <name>A0A401G6H3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0106470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608678.1">
        <property type="nucleotide sequence ID" value="XM_027752877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6H3"/>
    <dbReference type="FunCoup" id="A0A401G6H3">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6H3"/>
    <dbReference type="GeneID" id="38774682"/>
    <dbReference type="InParanoid" id="A0A401G6H3"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
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        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="5">
        <location>
            <begin position="258"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46035" checksum="7C395C6331DA6B88" modified="2019-05-08" version="1">MRFHIVGGFGAIGTLVTYYLRHALPRTNAITVLHKEPGIARASRRGDGRAIIETNGVVRWEKDISHDQIQSYSDSGREEYVARRLEAAAALGEEQPLFQEEEPVHTIESLILAIKANVAISIIKQLVPRLTADSTIVLLHNGMGVYEDLLKNVFRNPEHRPHIVVSSNTHGAWSKRRGYSVHSGVGSIHLGITPDGHGRDFEASVRSTLPKALQRTNLDDITSGPDDPAHARYASLRNTIEAFTMAEGLHASWRPVHDVQMAMRRKLVVNSVVNPLTALLNCKNADIFTVPGGERLCEALCKEASHVFHAQWKEEMKDEVSVTGNSMFPRELTTSALVQECKRVVEITGSNMSSMLVDVRRSRNTELDYLNGYIMRLAQQYKVPVHGMAAIINLMQLRCAIPLDNIHPFHEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7D6</accession>
    <name>A0A401G7D6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0109490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608980.1">
        <property type="nucleotide sequence ID" value="XM_027753179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7D6"/>
    <dbReference type="GeneID" id="38774984"/>
    <dbReference type="InParanoid" id="A0A401G7D6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="82" mass="8288" checksum="8DE62DCAEFEDCD25" modified="2019-05-08" version="1">MGACTKALTEGTLAMGPFLAVTCSGDGQPSDLWQWAHPSSYTLGGGPTAQKYPYGGGPTAQNITYGSGPTAQKYLYGGGPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7S2</accession>
    <name>A0A401G7S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0110810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609111.1">
        <property type="nucleotide sequence ID" value="XM_027753310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7S2"/>
    <dbReference type="GeneID" id="38775115"/>
    <dbReference type="InParanoid" id="A0A401G7S2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7452" checksum="B113CCBAD4F74D1A" modified="2019-05-08" version="1">MEARLPDRLTHPAEQSAVRDWSGVPHRASLSCQFRSCWCSSPSAPPRCSVYAVSNDLDNGFVAAYVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7W4</accession>
    <name>A0A401G7W4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Arginine-requiring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0111300</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609160.1">
        <property type="nucleotide sequence ID" value="XM_027753359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7W4"/>
    <dbReference type="FunCoup" id="A0A401G7W4">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7W4"/>
    <dbReference type="GeneID" id="38775164"/>
    <dbReference type="InParanoid" id="A0A401G7W4"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000070">
        <property type="entry name" value="Acetylglutamate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="421"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE78247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="623" mass="68334" checksum="121C172209321C31" modified="2019-05-08" version="1">MTLFSASVCRGARQVIPTNSRSAQTFKAFYATIRSLRQTTVPPDLDDVEPSEKDFIMSILRANPSLRDTRSYLASFGPRPVPPPRPAAKPDTQPVPITEGLHLKPDPPPLDVQHTLQSPVVSSILNPIQRRTALVKIQSPFTDRQLESIARGMVYLEKLGLVSVIIVENDELAKGEDGERAALVEEVMRVVSALESQGAKARPVLGAVVRLGPKPGDEESTEERDYAIPEAHTFSSDLVHIRSALRAGEIPVLAPLALDSFCRSVRVDANDVIAALARGMVEAAEEDRGQSSDREADGVDLTPLRLMIINREGGVPSYARSGMPHLLINLTSEYSHINDTFEGRWSGSHPTALSNLSLARTCLAFMPSSSSAVMVSHRSPSSLIANLITNKPAVSSSLPHALLQGNRKLMPYTPTLLRRGLPVRVVRSVADIDKQKLKALLEQSFKRTLDEAPFWDRLEKHLDYAIVAGDYAGAAVVTKEVRPTGASGSGPFITYLDKFAVLPSHQGDGTVDFLWVALHDESYGLGLPFSANPNGGKGGEGEGCDLVWRSRADNPVNKWYFERSTGHLRMGNWVLFWCDAEMRLKTEEGRRASAGLSYLEEWERGRLSVWADVIAKIPSSWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8B9</accession>
    <name>A0A401G8B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0113140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609339.1">
        <property type="nucleotide sequence ID" value="XM_027753538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8B9"/>
    <dbReference type="STRING" id="139825.A0A401G8B9"/>
    <dbReference type="GeneID" id="38775343"/>
    <dbReference type="InParanoid" id="A0A401G8B9"/>
    <dbReference type="OrthoDB" id="3203770at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="542"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="690" mass="73466" checksum="4DDDECE9B0DF77FF" modified="2019-05-08" version="1">MSAELTGPASGIRSRPITRSSIRQSLGKALADVMHKDSKESAVEKEKGSKKARDASARRTTTVHLAPRSSIDKPLLRKTERDVSPAAKDRTITRSSKRLSAIKRPATTSSDEQSSLATSPKTSVVRSATLRPRSSLASSALPKYRPKSALIETAPAKRSPSPHAGSRHLISESSDETEGIPKGKYITELQPPPSKASRSISPLPRRGALQVNLTSAINVRPVTPDKKSKNSSPAHAPSPRHTSSRPTKAAKTAVSQTASRTVIPRPPSSSSSSASPRTPKTPTGLSNIKRTGGSSSRDGSPSPRRGPALSAPESPLGKLSARKAANGSPTSIHRASASATPTRTTFTEGNSVDSVDANDVEFMLSAVASPTAPTPALPRFRTIYASESESPQTPSRSPFLPTRSNLSYISPAAPTSDNSPFLRPKAQYGANERGSILSWEQLARHNKTLDDEDVENMISQMPAPFDPGLISPAPSSVLLDIPESPNLSALPSPTGYGSISQVLLPDVTPSPAMYNTSLKFHHMDSDASMGDAANATLLRLQLASAESKAREQLAAIELLQSQLQSAKEARLRDAEELSRQMSQLEEQVHGNLRVDDQRSEYIASLEGQLLHAEALRDQAVQQALAQMHASAQASTATALRAQQARWEVACSAWDAGAAWGAVRDTAEGELELVRANREMLAVLLAGLNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8S4</accession>
    <name>A0A401G8S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0114600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609484.1">
        <property type="nucleotide sequence ID" value="XM_027753683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8S4"/>
    <dbReference type="GeneID" id="38775488"/>
    <dbReference type="InParanoid" id="A0A401G8S4"/>
    <dbReference type="OrthoDB" id="3352450at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="10583" checksum="4EA251410902EE70" modified="2019-05-08" version="1">MASDGTNDQLPIDAVADCTRQAQRDGIFAGVSAGLVGTILGSRLFRFNRNTTILCGIVTGVLSGYQFTQAFLSSNLARLKAEHAKRQTRGDSDSFIGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9G1</accession>
    <name>A0A401G9G1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0200070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609723.1">
        <property type="nucleotide sequence ID" value="XM_027753922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9G1"/>
    <dbReference type="STRING" id="139825.A0A401G9G1"/>
    <dbReference type="GeneID" id="38775727"/>
    <dbReference type="InParanoid" id="A0A401G9G1"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57234" checksum="1D7BA6F8ECE2CA5D" modified="2019-05-08" version="1">MRLSFERTRAIQIRSASQSVVCLLLDFNHLILAGDGRFTRPLPHFPHRIIHSFIAPKYEFLNSNFRRTGEKLFKFRVLQHTVVALSGEEARKVFFNDKRLNFNEGYRLFLGGAPQLSDINMLDADDAAIKFFYKYFQLVLTKERIMNVLPFLLDGMHKRMQIWGSKGRINPFKEIYDLVFWMTIRMASCSELADDTEASARFEENFWTLEQSSTPVALLLPWFPSRAKRNRERATRELYSMLQGYIDKRRNADVPSADTIDLLLQDGAEDAEIIQFILSVIFAGVTNTGMIVCWILLYFDQNPEWKAKVSAEVHNLLCTRTDSTGVALLHERLAALPMAAIEEETPALELVIRETIRLILANGTVLRRNVAKELRIGDQIVPRDAFMAYNLADVHLDPELYPDPTNFDPARFEAGREEDKKTTFGYLGWGAGRHPCVGMKIAKLEIKMVVALFLVGYDYKLVDANGHFPDPFPVRDPNDLLKARPMGKPCFIDFERIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9I7</accession>
    <name>A0A401G9I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609734.1">
        <property type="nucleotide sequence ID" value="XM_027753933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9I7"/>
    <dbReference type="GeneID" id="38775738"/>
    <dbReference type="InParanoid" id="A0A401G9I7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="97" mass="10623" checksum="E8F12FBCF06FB504" modified="2019-05-08" version="1">MDISTPRLGLIARRPRERGAVNAKRTVLSTAYQAVGWGTASRQLRVVRSRDRAGRTVRQRARIRAWREGCAGSWGGERAEAQICWGRGGGGDGSGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9J2</accession>
    <name>A0A401G9J2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0116960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609716.1">
        <property type="nucleotide sequence ID" value="XM_027753915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9J2"/>
    <dbReference type="GeneID" id="38775720"/>
    <dbReference type="InParanoid" id="A0A401G9J2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="58" mass="6316" checksum="A00CCDE8D386240E" modified="2019-05-08" version="1">MASSRYVEGSWRVVPDGETDGLIGRCTTSSSAPRSVCFETGHVDHVSRKALRRPALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9K8</accession>
    <name>A0A401G9K8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase ausD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0200380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609754.1">
        <property type="nucleotide sequence ID" value="XM_027753953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9K8"/>
    <dbReference type="STRING" id="139825.A0A401G9K8"/>
    <dbReference type="GeneID" id="38775758"/>
    <dbReference type="InParanoid" id="A0A401G9K8"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33990" checksum="E61AA5F839D6F434" modified="2019-05-08" version="1">MTTTNPVLLSGDLDAIREFQRAEESYYSLSDEELAFFKSQTDIQDEGMLKAHIILVQALAFAVFPYACIRRFTFLKLKISRMPKYEHLLKLGRERKDAIFLDIGCCFGNDVRKAVADGFPIENVIASDLEQEFWNLGHSLFNSTQEKFPVPFLRGDALDEAFLPVSPPLRTPAETPAPALSSLTSLAPLHGRVSAIHASSFFHLFGESQQAQLAHSLGALLSPVPGSVIFGAHAGMPTPCALDEESSRKKQYFCHSPQSWVELWEGVFGEGMVQVDARLDPASGTNILPTADNRPGKYTLVWSVMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Q2</accession>
    <name>A0A401G9Q2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0201010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609817.1">
        <property type="nucleotide sequence ID" value="XM_027754016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Q2"/>
    <dbReference type="GeneID" id="38775821"/>
    <dbReference type="InParanoid" id="A0A401G9Q2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="108" mass="11506" checksum="A55CC4E006249377" modified="2019-05-08" version="1">MLRHYRSHKSGSTSGILPPFGSIIGDADQLSSPAYISSPPVAFSSMSGTAPRGSPAYYWNDSDCEDVSESYIANDDDDSAPEEVNGSSTRARVGSCTLYGVGKELCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA08</accession>
    <name>A0A401GA08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0201990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609915.1">
        <property type="nucleotide sequence ID" value="XM_027754114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA08"/>
    <dbReference type="STRING" id="139825.A0A401GA08"/>
    <dbReference type="GeneID" id="38775919"/>
    <dbReference type="InParanoid" id="A0A401GA08"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34541" checksum="FB93CA3FD284ED22" modified="2019-05-08" version="1">MEQHPLMKSLSILSQATSGRLFNPWWRFIEKASVHRSEFTSARTEFFNIIEEIVQERKSSGKNLEDNGDFLSALLRDGQVQDPALLRDTLVTLLFAAKDNTQNSLAWSLYELSRSPVWLKKLRQEALSNGAPTQGVQYSNLGGYPIHLAVFYETLRLWPGVPKNSRVALKDDVLPAIPEEGYGPVRVSRGEYLLWSDYSTMRSEHVWGPDAKEFNPARHLDADGLFVKPPHPKFHSFGSGPRLCPGAQLAAYEFVVFWCSVLLWFDLVPVDDLVRLPADSLTVSMRDPLMVKVQWRSLSAVPDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAR3</accession>
    <name>A0A401GAR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0204560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610171.1">
        <property type="nucleotide sequence ID" value="XM_027754370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAR3"/>
    <dbReference type="STRING" id="139825.A0A401GAR3"/>
    <dbReference type="GeneID" id="38776175"/>
    <dbReference type="InParanoid" id="A0A401GAR3"/>
    <dbReference type="OrthoDB" id="3264915at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="528" mass="59282" checksum="EE680B3FE53E487C" modified="2019-05-08" version="1">MQMTAHLSSASDAATLLGLAHIDTSMADEPANGEQGVTVKRAKTAALIAQVSNHQMRLELLEEEKVMLQAELEEMKKLLHTYSARYTAVSERLDKQADLISELQTLVADLQERCISSDESNGSAEGSDSDDEVLDEKEKRRIEDSVAALKDTSYRELVRQAFQTRMGIPNLKPMSLPWWPKDGEPLPIDPATKTELMRFRWDLGWDAVENFENISTLVRMIMQQGGELVPTAVKAVRALGRVDVEDSVKKKFLALEKALRDAHKIEGRGRSVTAQIEIDGIDVLPSEEANSKLPARGQKKPSHRTSHTKGKLQVRKRKCAHLPKESMWHDPKYDAVFTDSLMSDDEDELNEKGEFTGHYISKAPTYRSQVLIDLFREIDAARDPTPSSKYIPCIKAVETIDEPPKVSKLLKNKARRWMIDPHWLAVETNQQYDVESHIVNSGRAWGDDEDPEETLEKQKRMREEKAVIVKNKKARLAENAQDKGEGSSKQKVVKKKGKGKIVKVSTGGDAGKGQNAAEDDDNDLYFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB98</accession>
    <name>A0A401GB98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0206480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610361.1">
        <property type="nucleotide sequence ID" value="XM_027754560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB98"/>
    <dbReference type="STRING" id="139825.A0A401GB98"/>
    <dbReference type="GeneID" id="38776365"/>
    <dbReference type="InParanoid" id="A0A401GB98"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="553"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112884" checksum="12D2464F70EDC179" modified="2019-05-08" version="1">MADSRKKTAARKAGKTKGSGQRSLLDHFHIKSNLSKADSFPGSESEHKQEVQDYVETMTVAELVDTTEGTLSTKPIDVEALPEHVVLGDEQEPASQQPRRLRPKEITMTSSISTTKSRAISRATTPEVQEIVDGSCRDVPIVVDATPWNGSDALSKRPAASKPLYSIFAPRAHSDSHLSDLDTGEKIPQPVQRNTKHSRDSPNTTVPYPDRDLQHVRGPQTTFPTPDISLPTRAVGSSSSTHPGPSPVPTEVEDEQIPTVPTSSSGSVVESALSLPLSAVSKDNPSPDALSSLLTSESITITDGGHISNDSAEVDYPANNTANDHISSTADSAEVDCTIHHLTEDHTSSTFDSAERAQFLDGLPTDHRRHPAIARLLEVQTREQDIGEPPTIAHELWTDKWRPRQATEVLGNEDRAAYLRAWLLALKLRIDSMAPLNIGTGSADSGRKAKKGTKSKLKAAGKRLKVLRQVEKPKKRRKLDAKDSWIVGTDESTEETTESEDEIAYCERTLQRLQRSYTDTSVNQSSELDVPSDSEDDAASVPSTSQPVFKKQVFNTILLTGPSGCGKTAAVYACAEELGWDVFEVYPGIGERSGAALNRLIGEVGKNHLVRQQHQLKATPSFNAQPGPSQGSQMKGPAGKRRLLRIDSAEDLAAAQCPPTPPTPNGDATTIGQSIILIEEVDVLYESDVNFWPTLVNIIKECRRPVVLTCNDVSVIPLRTLPLQTTLVFAPCPEPLAMSYLRCLSFVEHHGLDRSSISLLYHGVDASETRSGTRNHARYPDLRRSIHRLQFGNTAGGTGDIEEHNLEKRAHLLPRPLIPSRCGAHANQEDVEQNLSLLRLLDRYKDTMSFVGCHLGRGGLDTLRNPMTISTPPADDELGYFVAHDNLPFESALHVDLSVYRRDEVVMKEVVSYSNDLFASLYPALPLGEQEEISSQNHASSVKALMRKLRVPLDTLADNRSVFLDYEPWIRYMVAVDDAALQEVGQTQKERGRTTRNSQKLTTYQPYITPRDEDILRTFRFTSFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBC5</accession>
    <name>A0A401GBC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0206620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610375.1">
        <property type="nucleotide sequence ID" value="XM_027754574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBC5"/>
    <dbReference type="GeneID" id="38776379"/>
    <dbReference type="InParanoid" id="A0A401GBC5"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="146" mass="17368" checksum="46140BD52E93CB6D" modified="2019-05-08" version="1">MVAYWDSYPNFDHNARAPLRTEFERLATQRGWRAGSRRYRNEWAQCCVTEFGRHYGHHDRLDGWQALCVEVGIRDVPTSITACKKILNRTWVNLVDLIDCRRTGQRVQRHRSRDALRQYSVDNDKIFPKKEAKRNGFLKVLLIQMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC59</accession>
    <name>A0A401GC59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoporin nup82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0209770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610689.1">
        <property type="nucleotide sequence ID" value="XM_027754888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC59"/>
    <dbReference type="FunCoup" id="A0A401GC59">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC59"/>
    <dbReference type="GeneID" id="38776693"/>
    <dbReference type="InParanoid" id="A0A401GC59"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="848" mass="94094" checksum="DB176CBB0B3F808D" modified="2019-05-08" version="1">MDGEENWDLLLRGHPIFSPPLSVSHASGRGDISLELSLSSLPDFSDLDPDNDAPTPSGRRQVMVIKDSDLIVAAGSEIRMTSLVDFKLARNTRKSYKILHTPNVAFDVHQMALNPNSKLLAIAGAFQVAVIVLPRSGFTKLVPATIDCKSVQVGQFYHATKTSSPVAKIEWHPWGEGGSTLMVMTVDGQLREYDISVDAEEPQQILSFVPQRKKNTFFGTDPSEREVASFSLGKGRADWGPLTVYAAMRSGDVFAICPYMPKNASIPSSYVHALECFVAAKLEYLSKSRQEGSSSDSMAMIYDYQHRYVTALLKQLPPGTSFPATPRFISMHPPTTIKNTPMRRGPFLLQPSPRNLVGSEGGNATDIVYVSFGVDPEDSNEGDMERLGIVLVSFQDGKVDVYLDVEKIEAQWDHKQSSSADLPMFAVYETIDLGLVSAISKAKSEPSLLDLLQANHPVIYPDPIHEDSIYVYHAFGVHALQLKPLLKSLTVALRGADDKDTGSLSDVLQSSKCTEVRPILTTFSVEQKSTSPIVGVSIPCDVYLTYSIFVLTAAMRISVFPLLLSEDDFSETPEVSTKPEPKLLLALEGPTAYVSLLGKEPFATPAILSRPASLPSHPRLSLPASAIKSEFMVTADTLRYFATTAEFLTGQMQEVEAAHRASEARAELQFNEFARQRETCLQMLNIIERIKGRRRAEMKQRMERLHEAQKKLSARLDRTLQSLMEKASPELSVHETKWFEELRGMKQEVVGASKFDSRSLTVRAKVLQREVDRLLPNLKEIKEREMERRRNTSENRDVLGLSQAFELGEHSSAERARIGDLEDDILKLAAQLDITMGRPPPQQKTLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCB2</accession>
    <name>A0A401GCB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SAGA complex subunit spt3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0210290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610741.1">
        <property type="nucleotide sequence ID" value="XM_027754940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCB2"/>
    <dbReference type="FunCoup" id="A0A401GCB2">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCB2"/>
    <dbReference type="GeneID" id="38776745"/>
    <dbReference type="InParanoid" id="A0A401GCB2"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="354" mass="40337" checksum="F3C0B4FD8F796BDA" modified="2019-05-08" version="1">MAQVTAVKKTASDPTPQQRYKYAQEISQMMFVFGEVQDPNPDTVNLVEDIIRSQIIELIVQARALATRRGARYLSAEDLIFLIRHDRAKVNRLRTYLSWKDVRKHANAKDSNEGGAGVEVETLEDGADDKLTAKTQKITIKLPWEILTIYSDVLQTDDEEDEDDIEAHEASIQRLKEADDATRQMTREEYQHYSDCRQASFTYRKAKRFRDFLNLPPSLDLKANDDTIDIVGFLAFEMVRSLTLAGLEVKKSLEESYLREDHATSSPVLGKRKAGLGLGGDAKRMRRDEEDERDVDPPLPVCSLFLPPPEARTALRPEHIQDAFSRMQGDWAQRRSAGMRNWRGGLIRTTVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCB4</accession>
    <name>A0A401GCB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0209860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610698.1">
        <property type="nucleotide sequence ID" value="XM_027754897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCB4"/>
    <dbReference type="STRING" id="139825.A0A401GCB4"/>
    <dbReference type="GeneID" id="38776702"/>
    <dbReference type="InParanoid" id="A0A401GCB4"/>
    <dbReference type="OrthoDB" id="2801991at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="987" mass="109416" checksum="BEE8D3F1FC402911" modified="2019-05-08" version="1">MVTGVAGLPVLGTKGSPKKFKGSYAEVARFLQHYEWLCAQLNIVTAEDQVENITQYCAQSVRQFMESLPAYVTPDWNAFKRDILTFYDADRDKRRYKVKDLEALVKESRRKPTIKNLGAWQEYSRNFLTVAGWLVNRGHILEVEQSLYFWKGIPRAFRQDLEPCLLAADPNHNMSIPFSMSSVCMKAETILQHNRFDQDQLPSEDEDSSDDLDDSDSDDNSSDSEDSSSAEETHRRKRKDKKKMRSTKKQSSKRVDDSSDDEPEVKKPKTKLSWKRLAVHEKEEVEDLVKQLNRMSLSDPDYGLLYFCACKLDQLVTTVVRKPVVDAPTPAHSVMFVNWTPIYPDIVMNWTASGHRPIGATTGASQNEAKPELQDLDPKIEIKIGDRALDQDDIIELLGLGGLADSTLPPCLSQSHFEALITGLTVLPDTTPQTPGSNTPNSDDSRYMEPAPDLPITYAKDAGLLRSPPLPFSNLSPTAMTCRDDSPARVPLQEREYAMRMSSYTESHLDILPLPEHPILGNLTRDARGKSIYDLLSDAVSQYTQYRQYNMFSSVCLSSPATIVYAPMQTRYGPTHPCVQMMAMQAESHPDGMDRASICYGLAVSFFFGSDTHPPGSFFPTPIVGELFPSPSAGPRFSDDLAEAVGMTQRPQNAESEGNTLNNVSVGTELEPLTDTRFMLITSPPTPVSVTPESSNASSSKDLHSPTTVPAIPAHSPTLTAAPIVPAIIPAASPTVAALNSTQLAAVTDRHTALPLPRNVKKNVSMSPPSTVSLPPYSPTGRAALDLAIKELLAMPDHVLNQPARQLSRSPDTTAPVPLLPILSVKDLLYPPSPSSDIVSPATMIEHQETTEDVEMTDSDTSETISKAEWTAAVALENKSYVLAPYLGVRHDMIQLKNELYVRAKLYTLPFSFDQTNDFRRMFMVTFHAVMSRANIDGLEDSKETKDPIAMCIAAMVRQCRNYSALWYSHIGNPFLWPEEHLALAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCH1</accession>
    <name>A0A401GCH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Virilizer N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0210620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610773.1">
        <property type="nucleotide sequence ID" value="XM_027754972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCH1"/>
    <dbReference type="STRING" id="139825.A0A401GCH1"/>
    <dbReference type="GeneID" id="38776777"/>
    <dbReference type="InParanoid" id="A0A401GCH1"/>
    <dbReference type="OrthoDB" id="2011702at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026736">
        <property type="entry name" value="Virilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185:SF0">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1179" mass="131389" checksum="35AEDA3B81962C65" modified="2019-05-08" version="1">MLLQWCTLEPTGPDSLAAIRFSKAVRIQSIRIFPTDAQPFAQNPEIRSRTAPETFFLNIYFNAMHTHEKERLKATNALVPTMIAYTGGQVDFSVNMGSEFATRLMIVRGSFQSVSMAIYGDFASETTTFPELYKPLPLPSFEPPALSSALDPANTLDPTQLAMQLLSLIPDAPPLPLVIRLMFCLKPREEDWDLPDFPYLHPALDGDSIGFDLDKACRLSSQAMADNISEESLIHFAQHVTQAVDPKKDDHAYLVAEILSNAASQHQDMAKRLLQKLDLTTIFEGPKLRKPTLRRLLYATTNADIARHLNNDWFLETVDSIAKNSQIDLETRLAANKLVARIQGWETLEDALVNTQGDFSNASKMIAEVGRDEESLGVWLESMVTHHDIMANMSEIPVLSNSLPLPRLLLQSNSSTSHDEFTKFLRAFIGVSCVLAVYAWTDSLPHERCREKTLGILRLWQSVDGYREIVDHLLLLRQMTFRLGCMMDNEVPTRSGDDAEHILVNLSKTPRTFLSLNLADCILSLKSPHSFITDEELMFMQQAATIAKNGLLGAVDELVRPIGSPVTSSSLRNLRVALAIVEQDLQDRREWVVLGDFWEEGACSMVIRLVEVFLLTTEEIESHFSLKPLTFKSQDLMSQLFLLSNELLRLLHPLIPAYPLPSRVIRSLTIKIADLFTCTDAAESLYRESSPACVAAQMARQSCIDIICVLADTSLEGGKLGLEMVLRSLLQHGLRSEERDPAHHLLQVFWLIDILLPLPDSEKGPVSSMQRVVPNLLHDLWAFCRALDTDSKAHFVRRLVDLDRGVIGIGDWLLLEELKEIIQVTYSLEDTSLTASQQLVKRYRISLSLRFLLELVRTSGVSRWCIDCLTTEDEAVHIFTAFLTSLLDQHFLSSPLTELVAILTSESSPTQHDLCNVLVLVLLRSARSTDISTDMRNRLLHLSSTILSSTTFEMEDEDRLRSEFGELFATLSEASSALEGSTAETLVSLMEWLSAAAASGLPELTKLRGISSSTLSMFCDLLREAIPSDLQDRLANAKDKISVAEEMTSVTPLIPLPESLQLSMHDLEDLLRLDVPTPSTPPRNALNQDVLGLVTVSPIALIRSQASTGLTKTYVNNDFRQLRQMPSARQNTSRLPSMHVDEFESASPTLVSVPMPAVPATTPFAAEGFQQLAPPFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCM4</accession>
    <name>A0A401GCM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial import receptor subunit tom7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0210930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610804.1">
        <property type="nucleotide sequence ID" value="XM_027755003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCM4"/>
    <dbReference type="FunCoup" id="A0A401GCM4">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCM4"/>
    <dbReference type="GeneID" id="38776808"/>
    <dbReference type="InParanoid" id="A0A401GCM4"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE79891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="5841" checksum="06D8841C18183D9D" modified="2019-05-08" version="1">MPSEETKERIIKAIDFGRTVIHYGWIPLIIYIGYTRSNPQPSLIKLISPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD76</accession>
    <name>A0A401GD76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0213390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611049.1">
        <property type="nucleotide sequence ID" value="XM_027755248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD76"/>
    <dbReference type="GeneID" id="38777053"/>
    <dbReference type="InParanoid" id="A0A401GD76"/>
    <dbReference type="OrthoDB" id="3295430at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="12486" checksum="33BCF3B181A1A4B2" modified="2019-05-08" version="1">MRMLPQCHTPEDERQLRKFQKMVGLGRNPVIMVSCDGPEPARYKTMETPDFLIEWSILSFTEHSMSGELTVEKLLASYDGPEMPDVQSLSLEDTPKLLVTAKTEVDDKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFI2</accession>
    <name>A0A401GFI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0306690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611859.1">
        <property type="nucleotide sequence ID" value="XM_027756058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFI2"/>
    <dbReference type="GeneID" id="38777863"/>
    <dbReference type="InParanoid" id="A0A401GFI2"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="781"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="823"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="96096" checksum="BFE2042983F91855" modified="2019-05-08" version="1">MADVQNGRCFAKTALAAEPPLIQNGSVILQAHHIGWIISGSFTFVAIVVSFWLIDRHLVWYTNKREQRYIVRILFMVPIYAVVSFASYLYWNHSTALLLIRDCYESTVLTAFFYLLLTYLSPHVPEQKEIFRRVGLSCQNDREACRRGTKPRKWVFPLSFVRWKPEDGLYFFQLMKWGVLQYCVIRPVTTLVAVVLNYVGLYCGDSWSPGWGHIYITVVVSISVSVAMYCLIQLYLPISEYLAPHKPLLKLFAIKAVVFLTFWQETFISSLEVFGVIKDTQYMTADNIATGVGAVTETFEMMLFAFLHIRAFTYKPYRTAPERTPRWRSLVQVLNFKETLRELWAGAVYMAHRFRGHETDVQARREAVLEGVFGKSRYDIRRADQAGKNPIVVAMEETVHVDAEWQWLHAADGQTPPWEARDRWHREKSDPLAEQIKKGLSKTGYSKADRMNAPRYDRLGEVEESGAPAAGHWRREYSWWRDIYARISGSEMHWELEQEQTYNRASEPRGREDPTGQDQTRLLQHNVGEHDYEDQPPPSVIRTYRDSQKKKGLRDKDVPLAPQEPEALLSAFVSPERDPPPHPPADRQATLTSLQNRSSVVSSNVPSSPALTDSNQSDSFLGRAFPDVAYSSTSAEVVSVGRTSSESHRTRVRLPGEPEVVPESVQQLKTPVFVQSPHRVRPEVGTYPAALPIPSPASTDPSVRPGVPLARPAQSKSSGRGSATMRAPVLSDRRYSYGGRRSTPFIANRYTPSRDRIVLPARLAPITDREEATALSQVEPASSAVQLAPTPSSYSPLVRPLQVRGSMTASEDPPVGSRGLRRSTYNVRRQSYAPNSASPCRIHRDGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFK4</accession>
    <name>A0A401GFK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0306030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611796.1">
        <property type="nucleotide sequence ID" value="XM_027755995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFK4"/>
    <dbReference type="STRING" id="139825.A0A401GFK4"/>
    <dbReference type="GeneID" id="38777800"/>
    <dbReference type="InParanoid" id="A0A401GFK4"/>
    <dbReference type="OrthoDB" id="3070852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12778" checksum="15F936F3286E4476" modified="2019-05-08" version="1">MSNDSASEPPSSVVSFGSYADLHTSASSSTSCSSVDFGYNPFTSYGLLLGSGNQVWHPPMLPPDQSPRFIHPPMLPPDQSPCFIHPPMLLPDESSGMFLQPPMLHQDDTDTIRAQLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFQ4</accession>
    <name>A0A401GFQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0306550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611846.1">
        <property type="nucleotide sequence ID" value="XM_027756045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFQ4"/>
    <dbReference type="STRING" id="139825.A0A401GFQ4"/>
    <dbReference type="GeneID" id="38777850"/>
    <dbReference type="InParanoid" id="A0A401GFQ4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018807941" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="178"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="692" mass="74136" checksum="02BD289B93E4C308" modified="2019-05-08" version="1">MVKMLWSLLAYLTVLQVANAWQTYPDTDVVIVSNNDLNPLNANRASALYLKSAFTCSDAAAACAQLQESLLPAPNSTGLTAANLTAALISDKHGVAINLGQNIWIAGEDGGCATFLSSDSATESQSSDSNAAKLPALCTNSAPLTRSNVTSYDISRQIRLPTNSAGVLYGYRDKFSFRFLGIQYAESTAGAARFEPATSYQVSSNTERSAVAYGPMCAQPPDPDNGHLLHTEEDCLTLNVFTPLVNSATCPDETAPRLPVMFFIHGGGLNTGDSGPFPYNMTTDGFVGNSISNIYDGTNLVSYAGVVLVTINYRLTAFGWFNASNAALKDALLALQWVQDNIEAFGGDPTKVLIYGESAGGTMTRYLLGTNPAYTDGLFSAAILESDFGTSDPFLATPLALNQSLRLAKGLNCAPNTTTTFTEEIAACVKNSSAGDIALASFELGIAWSIAIDGDYVLTDIASSIKDGAYARVPTIWASNECEYCYFLPSTIPPDSSASVFPDSLPLYFNSTDVVLILNQTTLYPYETAPAEDGISGSVLTLAQLITDYYIHCPMVYLASLETNTTNPGNAYKVEFGVGLGSPLTPNPATCVGQVCHADELYWVFATAETDDLYQPLSESEVETTREIINRWTSLAWDGNPNYEGALVEWSPYTGDNEVVILNSTQSIEPYRVAQCLFLQSQLGLVFGEDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFX2</accession>
    <name>A0A401GFX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0308030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611991.1">
        <property type="nucleotide sequence ID" value="XM_027756190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFX2"/>
    <dbReference type="GeneID" id="38777995"/>
    <dbReference type="InParanoid" id="A0A401GFX2"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="339" mass="39211" checksum="C1CA42294BEBC3FF" modified="2019-05-08" version="1">MSAQFRLPDTLATWPWPREINPYYDEVMAESSEWFRSFHAFSEKAQRAFDLCDFSRLASLAYPALTREQLRTGCDLMNVFFVFDEYTDNEPVDVVKQIAEISMDALRNPHKARPAGENVVGEITRQYWERGILTATPTAQRRFIGTWERFTASVIRQAEDRSQNHIRTIPEYLALRRYTIGGEPSYAMLELGLNIPDEAFYHPTMVELTWVVTDMIIVGNDIFSYNKEQAAGDDMHNIVTIAMNDLQTDIYGAMEWIDGFHRELVERFFDLWAKLQELSWGPEVDQEVPEYARGLAGWVRANDCWSFESGRYFGTKGLDIQKHRMVTLLPKSKGAEDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFY0</accession>
    <name>A0A401GFY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0308210</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612009.1">
        <property type="nucleotide sequence ID" value="XM_027756208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFY0"/>
    <dbReference type="FunCoup" id="A0A401GFY0">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFY0"/>
    <dbReference type="GeneID" id="38778013"/>
    <dbReference type="InParanoid" id="A0A401GFY0"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="14">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="453"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="694"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="823"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1005"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1010"/>
            <end position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE81096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1086" mass="118979" checksum="AE4AF0ACA58BDA89" modified="2019-05-08" version="1">MSPVAMPVASDPQFTPLIDALRTAPTSPDAKAAADRLAREVSKTGLYALSDAHIISSLHNFATNKKSGYERESAAVAFHSLCTVLGAPVAPLLLPSLPILFDLYMDKGDVVRAAAATATKSLLKLFPPESTRIVFRHLEDILNNGKWRTKVGVLDAMKGFVNSARDAVANELGATLPKVEAAMHDTKSEVSSAANKCATALCSTLANPDLTPHIPSLVKCMANPDSVPACIKSLSSTTFVAEVTAPALAVLVPLMIRALNDRSMEVQRRTVVVIDNLVKLVRDPNIAATYLSSLVDGVEKIAKGAAFPEVRAFAETALITLLKAGASKDGTPPTHRDIEAETASTLTVVLTLLPEELRLESPQNPSGPHIPRHTLLKQVLDFVASLTTDLVYARRFSDSGTWNRCIGVYVGPWLSDRVTAGPQFAEIVRLHFLAIDQAKYAPAQNGTSDEGEVLCDTLFSLAYGALLLLSHTRLRLIRGRRYGILGTNGSGKSTLMRQLRDGKVENFPPQDQLRCVMVEHSLQGEDTSLSVIDFVTSDKALSGIPKSKIRDQLMEVGFDDSRQAEVVGGLSGGWKMKLELARAMLYHADLLLLDEPTNHLDRASVKWLEQYLMAQKQVTCLIISHDSGFLDTVTTDIIHYESKKLVYYPGNLSSFVEKHPEAKSYYTLAATSVKFSFPPPGSLMGVRSNTRAILKMTNCTFTYPGRNKPSLFNVSCALSLSSRVGIIGPNGAGKSTLVKLLTGETEPQEGSVYKHPALRIGYVSQHATHHIERHLEKTPIQYIQWRFQDGHDREILEKATRVLTEEEKAQMETDFIGKNGQRRKLEMIMGRQKLKKSFQYEIKWRGLDHKFNTWVPRDELIEKGFAKLVHQFDDLESSREGAGSRDTAAHVVRKHLEDIGLDGDIAQYNEISGLSGGQKIKLVIAACLWNNPQICVLDEPSNFLDREALGGLAVAIRDWAGAVVIISHNEEFVTALCPEIWNVEAGRMTHKGKVTVVEDAFAFKSPKGSGANTPSRSAVQSPDASVHGTPVVSGAEDKLGAATPPVKKKKKLTRNQMKAQEERRRVRKFNWLAFGGPKPEDTDSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG09</accession>
    <name>A0A401GG09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rhizopuspepsin-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0308500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612037.1">
        <property type="nucleotide sequence ID" value="XM_027756236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG09"/>
    <dbReference type="STRING" id="139825.A0A401GG09"/>
    <dbReference type="GeneID" id="38778041"/>
    <dbReference type="InParanoid" id="A0A401GG09"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018991150" evidence="3">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="68"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="312" mass="33195" checksum="900685239CB1124B" modified="2019-05-08" version="1">MLSVCTLGLLALAATVSAAPAPIAAVPSKISLMSCKASKRDIDAMQRRSLSSAGVPLEDYYSGTDLQWYGNISVRTPPQTLTVVFDTGSETLEFASTQCSTCSNQVRFDPSQSSIYVDEGQTSTIDFATGIGVNPVESQDEYELTLLSGRDTVTVEGLTATDVELYTITKQSAAFDIDPFSGIQGMSSQAGGFFSGLVQQGLPSLFGMYLTPEAVGNAKLTIGGYDNTKFQGDLTYASLSGGSGGTWLITSNQITVNGQTSSQLLNEQLVIFDSGTSSVVLDKETTEAIYAMISPDIKANSEELWNHLQQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGH0</accession>
    <name>A0A401GGH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">PH and SEC7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0309300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612116.1">
        <property type="nucleotide sequence ID" value="XM_027756315.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGH0"/>
    <dbReference type="GeneID" id="38778120"/>
    <dbReference type="InParanoid" id="A0A401GGH0"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
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                <person name="Furutani Y."/>
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                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
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                <person name="Furutani Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112097" checksum="72909A36118FDA6C" modified="2019-05-08" version="1">MSSDSSRESSPARRRPPSPGSDSNQSASSGGSSQPRHEPSASSGFQQYAGTSASAFQSSAGTSAYQPPAGTSLSAFKSSPYTYSAKSTTTTPILRQPVGFGGTVPKASSTYSASATAAPATEHTPDQGTAATSSSKSKSEKTSKSKDKEKVKSASSGKGKEKAKPSSSHRGREKEKETARHPSDGLPSGAPPVRKGVVPSANKTTFRVHNYTNDPSAARPSPVPTDGPYKSDYRAVPAPHGREAAHPTTANPDLEQEPRRSYYRHDYERQRDNAPARRRAKVAAAENDAPVPVPTPALIEVTSPTPIVPPSPTSVPAAAHGYAYPPTPASAYSPATPVTHSHAQVSTSSHRHRHASPTGYARVSTPAPAHVQTPSRTYARTPGLTSEPMQAYATPSSMSSPTPAYSQPPTPMADRRSFDHSKPLEDSYRPSSPPSNRAYSTPERYHGTDSHAHSSHSHYPSTSPSKSYVPHTPVPPSLPPLASITSQQPIRYLRVLTLLIEDNRNGQTENQLAELRVELRESPDGCYLADAKDICDALQSSPSRIDGSAKVFTMRGKYRHYFLRLTSEGEMECSPVNLTVTMDRTIEIFIEDNPMPGASSHLRLPSLVERDMLTPITDPMKTPSPAANSQLMAPLRVDMVAEREYSDQRHRKHRKRHRSSSSRSIDYPALHYPSHEPPPRSLESTPFSHASSPPISSSYSYMSSPQPSPTSQTSSLPQAAYLAPTSPHSAQAGMRHKSPTAFGTTPTQQDHLGHQYDESYQRRPSSPKRPRIDHAHLGVSNDARYAWDDSRTRSTLSSSLAPPTSMIPVNPRSDSTSMLTPQSEGNRTPSSHGRIPTSHERTPSTHEWTRTYYDRSYSSHERSNAPIPSELVAESTTAMVDSVGAYLRSIVSQEPQWQTFVDMRNRICRMSELLEQYRYMKRMFDRFVSQYTPSDLKDAPSVQITRAQVLKAYNLPTSWGDNCMEVLSLVALYGPNGKRYEDRRVVDMFDEVPPVTTKLQLEKFLALLRECHSRWTIDHPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH74</accession>
    <name>A0A401GH74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612467.1">
        <property type="nucleotide sequence ID" value="XM_027756666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH74"/>
    <dbReference type="GeneID" id="38778471"/>
    <dbReference type="InParanoid" id="A0A401GH74"/>
    <dbReference type="OrthoDB" id="3036073at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="259" mass="29427" checksum="5EE54ED84406D4DF" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGKDAKWPLKPTVEDAPDEEVSIFKEDGLPELITTKTSSTSFGHSESIREIMADNTERGELPAVRNNTEPDDPLSEPPMDQLDDNDLVISYIAGEPIIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVKELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHH5</accession>
    <name>A0A401GHH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized FAD-linked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0313270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612511.1">
        <property type="nucleotide sequence ID" value="XM_027756710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHH5"/>
    <dbReference type="STRING" id="139825.A0A401GHH5"/>
    <dbReference type="GeneID" id="38778515"/>
    <dbReference type="InParanoid" id="A0A401GHH5"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019247097" evidence="6">
        <location>
            <begin position="23"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="610" mass="64490" checksum="C139C551400B4935" modified="2019-05-08" version="1">MLRSRSLVSTLLIAFAAFGVRAQTDDDSSYTPNYVTLSSPSWPSAASWNALNSSVGGKLSALRPWTAVCYASDPLFDESACQTVLSNYSSDTTREAHAAALLWDNWETCGYGDGCGLDVSDPKIVYNKTCEQGAIPPYSVEVSDAQEVSAVVNWAVQNNVKTIVKNTGHDYLGRSAAPSTLQVWTHSMNSITYDAAFVPQGSSSSPVPAVTIGAGAQVENIYAFLEDNNISAVLGGCLTVGAAGGFVQGGGHGPMSPTYGLAADNVLQVEIVTADGTIRTINVVQDLDLFWALRGGGAGTYGIVTSVTLAAHPPTTVSTSLLTVTPDPSLNASELAIGWINLTAQYANEWNENGLAMASVVSSTRYYLNLYWPSDSAPLSILDPFFEAVLSNAVYTIDSNTTADAAFSSFTAAEMQSIGPFFEALNMYGANSRMASRLIPYTYFSSPSSAGQVAQAIWEGHQVLNGPLTGGAAGTPGEVPVLILGDMPAATRGQSDATGANPGLYEATWHTVYASVWFSAATEATMEAVVDAAHAATGPLTKLGVTTSYQNEGDAYETDWQNTFFGSKYQKLLSIKQNYDPSNFFNTWRGVGSIDTLDAWACFRAAAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHW0</accession>
    <name>A0A401GHW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612662.1">
        <property type="nucleotide sequence ID" value="XM_027756861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHW0"/>
    <dbReference type="STRING" id="139825.A0A401GHW0"/>
    <dbReference type="GeneID" id="38778666"/>
    <dbReference type="InParanoid" id="A0A401GHW0"/>
    <dbReference type="OrthoDB" id="2422225at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28194" checksum="5F1186A22F8F47DB" modified="2019-05-08" version="1">MILAENTDGPFYRIKNIVDYDTTKAAYQEELAYFVSLGHHQSEMDKKKSVGGLKLLNYLSSYLVTQEYWLQWSHAGAIKAAEILGVRPEDVPRMTNHLESHNNHLKGDYFQDHKHGGRLSCIDVWIFILIMQVIPDFFAHRNNMDQLCNHYDYLRTAPKACLAYPAPTVLSESVAGESLTEYEADLLHTMLTDDSRTNDTAQTEPETEMALCSGNSDWSLTVTMASTTRHSPSPMSEDAQGLETCGSHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI61</accession>
    <name>A0A401GI61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0401860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612726.1">
        <property type="nucleotide sequence ID" value="XM_027756925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI61"/>
    <dbReference type="STRING" id="139825.A0A401GI61"/>
    <dbReference type="GeneID" id="38778730"/>
    <dbReference type="InParanoid" id="A0A401GI61"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="757"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="671"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="713"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114305" checksum="CF5DDA92503216D3" modified="2019-05-08" version="1">MAQRRAHHHRISSVPDSTAILTRRKLQSRRGASARRRAFTLADPYGRTSSSRDSRASGSSPPTSARPVLVPLQFNLRRLPSRLFSERKESMRDAGDGYTVRAGAKRKRVVSGSENTAGARSTRNAGRVKRRRAVRESSDEDEMSGMDIDDQAHWESSDNSEDEGAMDSSDDFLIHEADPRQLFRMRKEELVRLYIAAGLTEDAELLTKHEIVDCIVAARDDVAELPPSSPGIGDSNSSDYSSDGGNVAGGEETDFGGKFRNGLRRRATVQDLGRSARSTAASRSLSLGQLEAAPSHGKRAREPSGPSCPIRRRGTSNASSSRSSPTSSAAYSLPSPPATRLRTRKLSNEDSVASTSARLSKGKGKAKQVEFNDEVQVKSKPVTRPFDDESDLTDLTEVEQSIAKISPSPRRLRSKGERPRSEKEIPVETAFDADRRVTPMRKAKGKVGCLREEDEEEEEEEVDQLESGTDQDEEVDQLTETPSPMATPKAAVPRGRWTPVVRRLRPRRIQTHTPPSDGDDEGSENDEGADVETSVDGEDEENEGDDERSVVDGESEEEEEQPPPEPKKLRNGKIVPDGEVEDEVAEEDDDEGDEDYADSTVEDVDAEGETEESEGTDEPMDDDVDLTIATARTLVRLRRDDLVRLCETRDLDASGTKSQLADTLLQWRDRHCSEASSPSSTGTARPPSTAKGRPGRRKTRSKSNSQTPPVLLRSDRVHMDEPRTPPLSGQQKEAEPELELDLESLGLEDREIPPDKLTKLEKIGSGGFKDVFIGKFKGRRVAISEFRSQLSAMDIKELKLLGDFDHPNIVRFLGVSIPENTRETPVMIVSELCSNGDLFDYVRNVKPPSLYRVLCIMLDIARGLEYLHMRKPSVIHRDCKSSNILITSKGIAKITDFGLAKVKQSTRSMVRSLVGTVNWQAPELWHPHPKYNHKVDVFSCGMVYWEMLQWHVLNKKFPWEGMNEHAIYDLVGAKRQRPSINGLRKHWCPEIVDLIERMWAQEPDERPTMSEIVEELEHLVQIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GID9</accession>
    <name>A0A401GID9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0403460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612883.1">
        <property type="nucleotide sequence ID" value="XM_027757082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GID9"/>
    <dbReference type="FunCoup" id="A0A401GID9">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GID9"/>
    <dbReference type="GeneID" id="38778887"/>
    <dbReference type="InParanoid" id="A0A401GID9"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8622" checksum="D0BACE5ABE577AF8" modified="2019-05-08" version="1">MMAVTDKTLGGAMLLLATSVFSYYTIWAILLPLFESSNPIHDMFPSREWAVRIPAFLLIIGMSAIGLFVGSAIVADPTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIG8</accession>
    <name>A0A401GIG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MCM7</name>
        <name evidence="15" type="ORF">SCP_0402690</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIG8"/>
    <dbReference type="FunCoup" id="A0A401GIG8">
        <property type="interactions" value="662"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIG8"/>
    <dbReference type="InParanoid" id="A0A401GIG8"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="354"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="700"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE81895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="785" mass="88919" checksum="19A3C5785D277DED" modified="2019-05-08" version="1">MSLPVVNINIDYETEKELIKNFLSTFKGQEKDLARGIADIDLDNDEEMPTVTVGLKYMVYLQHIANREQEMLIIDLEDIAEHEKTVAELVARIRLNTRRYVTLFSEVVDKLMPVPTKDISEQDEVIDVILHQRRERNERLEGGQEGFPDHLLRRYNLYFKPLLSDIAMAVREVRGTHLGKLITVRGIVTRVSEVKPLLRVNAYTCDVCGSETFQQVSNKQFTPIFDCQNENECKKNGIHGSLHMQTRACRFSPFQEVKIQEMADQVPVGHIPRSMTIHVHGNLTRQMSPGDVVHIGGIFLPIPYTGFQAIRAGLLTDTYVEAHHIHQLKKQYNDMEITPETRQAILELKDDPQLYNKLAQSIAPEIYGHVDVKKALLLLLVGGVTKTLGDGMKIRGDLNMCLMGDPGVAKSQLLKYISKVAPRGVYTTGKGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMEEADRTAIHEVMEQQTISISKAGISTTLNARTSILAAANPLYGRYNPKVSPVENINLPAALLSRFDLLFLMLDKPSRDDDERLAQHVAYVHMYNRHPEQEFDLVDPNLVRHYIALARQRRPTVPPEVSNYVVESYVRLRKLSKDEEEQKKSHTYTSARTLLGVLRLAQALCRLRFSDLVDHADVDEALRLMEVSKESLQDDDDKDRDQDRSDVSQIYRLIKEMSTDVRAGAKGKQRKGRSRRMGRGPAGEHDMDVDDEDEDDVEELSMVEIRARVLRSGFTEAQLMETIQQYEGIDVWTRVANNSKLRFIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIL7</accession>
    <name>A0A401GIL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0403490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612886.1">
        <property type="nucleotide sequence ID" value="XM_027757085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIL7"/>
    <dbReference type="GeneID" id="38778890"/>
    <dbReference type="InParanoid" id="A0A401GIL7"/>
    <dbReference type="OrthoDB" id="3260031at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="69546" checksum="EC53420779EFAE7D" modified="2019-05-08" version="1">MRAQLDDDAKIRAACKYVSLDKADLWMGVMERETYEQFKNAVIALYPGAEDDRCYMQSDLTQIVRTARTRGVSSRAEEGQYYRDFTYLYLEGFKASPLHAIKNRLAIKVPDQNPDDSYAISEVHSTAQHVLSGSGSASSAVAVSKLSTGTVKLEGNETDAMRFLANVLQQAMRTSGGGQAPVSQANIQAAVAQNPLPQALRACNFCLAIDHFMRNCPRIEDYIRARKINRDALSRIILPNGRFISRDLPGCSMAEHVDAWHDMYPGNLFGDGPGPSAAPLPNVSRDGHDQPPHMVSLWEIAKEALNPKEPSLAYIEECLDDSTMSVLEANVAPKKKTVWFNDSAAGKSAKRPPGVPASQVPTSILKPASDPSAAPRGGAKASLPSPGNRATQYSYKMPVEDKVNVRDIFEHIQNEVRISLMHRELMALCPEIRKLEQEEITAKRVATTGSFEAVDGEEVAEALLVDVSDGGGLLVVADDSLPLRAIDALVKGKESVECILDQGSQIIAMRRDIWECIGSTLQSEKTLNMESANMGINQMLGRLANIRFGFGEIDLYLQAHVLNDAPFEVLLGRLFFTLMACKTPDFTNGEQHITLRDPNTRQVVMLPTHERRPRPRPMPPPGMGFQDSRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIU4</accession>
    <name>A0A401GIU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 7">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0404710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 7"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613005.1">
        <property type="nucleotide sequence ID" value="XM_027757204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIU4"/>
    <dbReference type="FunCoup" id="A0A401GIU4">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIU4"/>
    <dbReference type="GeneID" id="38779009"/>
    <dbReference type="InParanoid" id="A0A401GIU4"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="10">
        <location>
            <begin position="153"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="11">
        <location>
            <begin position="325"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE82092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="557" mass="62465" checksum="604CE8B1724453A4" modified="2019-05-08" version="1">MSSQKAKQKEVAEPEADQPENDAQDDSGSDLSEEDHDQASSTLPEASVSSASIKKKKKKRSKALKALRGSKDGIPQKVVDAVLEKVRAEGGEAASADEATVRMALEHLKIKDVIQGKAGIGGRNRKDTGDHKFWATQPVPQLGEGPPLADGYIEPSIPPEEVRQEAYPLPKDFEWSTLDINDPSQLRELYELLSGHYVEDDDASFRFQYSAEFLQWALMPPGYNKEWHLGVRVASNKKLVAFVSGIPLTLRVRENVFNASEVNFLCVHKKLRSKRLAPVLIKEITRLCHRKGVFQALYTAGVLLPTPISTCRYHHRCLNIHKLVDVRFTHVPSNMTLARMIRLNKVPDRPHLLDPQFGLREMEEKDVPKVAELFAKFMRRFGMVQVMTLDEVRHYLLSGTGEGPRTKDSWSTRREGQVVWTYVVENPETHKITDFFSFYSLPSTIINSEKHNVLQAAYLFYYATDVALHDAAELDGRLKKRLEELIGDCLVTANAAGFDVLNALSLMDNCQFMQDLKFGLGDGMLNYYLYNWRTAPLAGVNAIGDVPAGKGIGVVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ22</accession>
    <name>A0A401GJ22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposon Ty3-G Gag-Pol polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0405930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613123.1">
        <property type="nucleotide sequence ID" value="XM_027757322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ22"/>
    <dbReference type="STRING" id="139825.A0A401GJ22"/>
    <dbReference type="GeneID" id="38779127"/>
    <dbReference type="InParanoid" id="A0A401GJ22"/>
    <dbReference type="OrthoDB" id="2797467at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="195" mass="21988" checksum="8093A5367C62D234" modified="2019-05-08" version="1">MNTVNSSTGFSPFQLKTGHSPRFVPPFSDVSLVDDTSDETAHAAKLFTRLETDVMEAQDNLFLAKVNQAALTNHLRSEEISYAVGDKVLLSTFHRQQDYMQQGDNRVAKFMVCYDEPYNILHTYPEFSAYILDLPASTNIFPTFHASLLKPWCKNNASLFPSCQHSQPGPIITDDGAEEWEVESVIDHRPRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJD1</accession>
    <name>A0A401GJD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0406610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613190.1">
        <property type="nucleotide sequence ID" value="XM_027757389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJD1"/>
    <dbReference type="STRING" id="139825.A0A401GJD1"/>
    <dbReference type="GeneID" id="38779194"/>
    <dbReference type="InParanoid" id="A0A401GJD1"/>
    <dbReference type="OrthoDB" id="2663544at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="293" mass="31859" checksum="9C2E466D0DD120D1" modified="2019-05-08" version="1">MEQKRQHEENNQQMADMSQQILKMEGMIGMLVNSKSTRKSKPAAFVAPSPSPTTSAPAAPPAALPAVAPPTITINFHGSDGPGGSVATPTIPSITASVTETLSGSVPLITTATSSGSTGSAAPAPLALAPLAVLGLVPPVAALAYTGPWSARREELQCMYGEDAFNKHKPWVWKVGELLPSYQYQPMSTIMDVWTEWTAGLGGHIPVRELTEKWGNHWRHNNAALKMEGGHRKKIIELIAELSQKSRWSVQLALHFLEEKYHLRYRAHKFCEYLTESGGVGRLEVLKAAMKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJJ8</accession>
    <name>A0A401GJJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0407310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613260.1">
        <property type="nucleotide sequence ID" value="XM_027757459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJJ8"/>
    <dbReference type="STRING" id="139825.A0A401GJJ8"/>
    <dbReference type="GeneID" id="38779264"/>
    <dbReference type="InParanoid" id="A0A401GJJ8"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="285" mass="31977" checksum="2F9E1AABABB31D02" modified="2019-05-08" version="1">MTSPHLKAVIFDIGGVVCRSPLIAIAKYERERGIPYNYINCSITGRGSQGAWQKFERGELSLFPFYAAFGRELSDTTRGNVWYAEYCKRKGIECPELPQTLNIDGRELFGRMMRESGSWDERIVDAIRRIRASGRWRVIALTNNFGKSERDMVGDAPPSLDQYPDFSIESELEFLGWQEGPTPPRLRELFDDFCDSSTFGMRKPERAFYVLACERNDILPSEAVFLDDLGLNLKVAQNLGMETIQVPIGDSLGALKKLEGKLGVDLTSHGGIAPRHGMQGTLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKS2</accession>
    <name>A0A401GKS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0411350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613663.1">
        <property type="nucleotide sequence ID" value="XM_027757862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKS2"/>
    <dbReference type="GeneID" id="38779667"/>
    <dbReference type="InParanoid" id="A0A401GKS2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="111" mass="13096" checksum="7484CE05EEF32BF7" modified="2019-05-08" version="1">MRDMKDKLTVGGWKRLPEKIQNAFIELQLQLSTLREHSGGDDVAPMNKVTTRENYDKGVSQLPLLLFDREGHHPSRQWPEFWTVLQKSQNPRYQQNRQMDRASRAWMPDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLC3</accession>
    <name>A0A401GLC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0500080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613878.1">
        <property type="nucleotide sequence ID" value="XM_027758077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLC3"/>
    <dbReference type="GeneID" id="38779882"/>
    <dbReference type="InParanoid" id="A0A401GLC3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="17480" checksum="442644E18E1430BA" modified="2019-05-08" version="1">MEYATSAEAPAAPLQLRLPLDSAHGPTVTKASTSLASPNGALVTSSSRPTDFTMSFFSNQVPAGPAGTYQPTEHHPERFCARRECLLLDMSDTYLVYVPDSQDASCWRWPHLCTIFCLYHPRPSLSEPSTSLALSEPGEAERKIVPIVSLIGDSVGCDITPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNW9</accession>
    <name>A0A401GNW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box/WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0504930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614357.1">
        <property type="nucleotide sequence ID" value="XM_027758556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNW9"/>
    <dbReference type="STRING" id="139825.A0A401GNW9"/>
    <dbReference type="GeneID" id="38780361"/>
    <dbReference type="InParanoid" id="A0A401GNW9"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="351"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="469"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="509"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="549"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="673" mass="74175" checksum="CC88979308BAC82E" modified="2019-05-08" version="1">MASSTVFTSQNITASEAERTPRFGKLFTSGLGSPFLTTADLPGDDDVANADTNAGNAELDLEDVDGAFAAVPRAFTITRPVSPTPSFRTENYSIINWDATTFATIYGSGDRTPRCSAAFLPSSRRTLAGYPYCPPSSPTQLKSSRSLTLGIIPRIWDALREGSPGKKGKRRPGLPSASAWRESGWVVDTYDSDECVDYSSMLPLDGEEGELIDDEACFIDIRAVTGVDIVALLPPELALHLLSFLDLPAIIACLRVSRTWNRLADDNSIWCTLFSQREADGWRADLRRAHSASPALLYPSLSSSRALLPAPLEIDWYETYRTRTELDRRWSVAPNSKSSTSQSWEPVVRRISGHRDSVYCLEFDSSRIITGSRDLTIKVWSLKTGRCLGSFAGHRGSVLCLKFDKDWDTVDNVGEDDDEDVQTARVRKGFLVSGSSDCSVCVWDLSVLRPADGEVQGEQPVTAEVRAVLKGHSGGVLDLRIDSNWIVSCSKDALIRVWDRKTLGLHCTLRGHEGPVNAVGLQGHRVVSASGDGKMMLWDIATGERLRTFEGHDRGLACIEFKDDLIVSGSNDCKIKVWSASTGTCLRTLVGHEMLVRALSFDPRSGRLVSGSYDKTVKVWDLHTGRMVREFRGCHESHIFDVKFDHCRIVSTSHDQHIIILDFSEGLDVSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPD5</accession>
    <name>A0A401GPD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614991.1">
        <property type="nucleotide sequence ID" value="XM_027759190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPD5"/>
    <dbReference type="GeneID" id="38780995"/>
    <dbReference type="InParanoid" id="A0A401GPD5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39811" checksum="00C59B58174FAB2D" modified="2019-05-08" version="1">MQTITSLWNGTAESLEELSVLCQTEPRKTFDLNLAAPKLRRIVLVEAAYLPYRMNLAYHFPALERIVLEGFALESLMGPDQQCKDVIDLLVPLPHLRSLDLRFLQHGTAIPPQYQFDRVLLADLESISFKFLHPDDVSEFMSVFYAPRLASMHYTMPNTEDPYRIPLVFDHTRYFPQLHTLIVECDHRNELKVDSSFALFLHGFNHVEFVDFTSGEFASLVGLAGGSVSMGDWSASTSPPVSLEIQYTPVTGVIVKSLRQVIETRRVASLPDPTDPEMELAPALEELHVCTQERISDEDRSWFEENIRTFTWLETGSNKEKAGENWTPGSGWMRMTFAPCEDLHFRLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPH8</accession>
    <name>A0A401GPH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mug135-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0601130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0612 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615048.1">
        <property type="nucleotide sequence ID" value="XM_027759247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPH8"/>
    <dbReference type="STRING" id="139825.A0A401GPH8"/>
    <dbReference type="GeneID" id="38781052"/>
    <dbReference type="InParanoid" id="A0A401GPH8"/>
    <dbReference type="OrthoDB" id="5104026at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013902">
        <property type="entry name" value="Mug135-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08593">
        <property type="entry name" value="Mug135_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mug135-like C-terminal" evidence="2">
        <location>
            <begin position="269"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="38010" checksum="33B29DF241190263" modified="2019-05-08" version="1">MPERVAIPSSPIATDSETRILQALPLNGITIPATPEQHMLAVTYQNIVLNKFKDDSSKAAVKGQAEQAVMFVDKIAGLRAMHQEIDGVVTRQFEQHAVEAVDGVADRVFQKISQQLQVIIETMGTNNTSLNERITTLDEDIGKRFDNFDNRIKTLQEDVDGRFKTLQEDVDGRFQTLQQNVDGRFQTLQQNVDDRFQTLQQNVDGRFQTLQQNVDGRFQTLQQNVDGRFQTIQQNMDAHVQTLGQRIDHLQVSIMRLDARVANTIAGRSSVQMQLVPIGDDLGQTAPQGHQPLTNRNQIENMTASDLTLWLNHYHITVPHGVVDRRRALQQFYGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQE5</accession>
    <name>A0A401GQE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0604250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615359.1">
        <property type="nucleotide sequence ID" value="XM_027759558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQE5"/>
    <dbReference type="GeneID" id="38781363"/>
    <dbReference type="InParanoid" id="A0A401GQE5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="234" mass="24003" checksum="CCBFBB34D66CD892" modified="2019-05-08" version="1">MQVRALALVSSSASDGAHGASYQIGSEIFGTSAGLKLSASSSSYAFSSHSPPPPITSRSKETTRVSSTDGGMDAAAIIRSILSSSVYTPFLVLPAPPSTPGMSPAKTTQQMHHPAASIPSPLPFFPPSRFLPSYAPSSSTSMPPQPRLSVTSSSKVIASLLSPRHMSTGQPQSVPHSTSNATARATSSSGTIHTGANNWCLNCKSYSFIFPAASSLPGARASLLMVTPILVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQG6</accession>
    <name>A0A401GQG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615312.1">
        <property type="nucleotide sequence ID" value="XM_027759511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQG6"/>
    <dbReference type="STRING" id="139825.A0A401GQG6"/>
    <dbReference type="GeneID" id="38781316"/>
    <dbReference type="InParanoid" id="A0A401GQG6"/>
    <dbReference type="OrthoDB" id="2500073at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="128" mass="13771" checksum="75EBE5B7B7B29370" modified="2019-05-08" version="1">MSATEVQDMNGTQASPAPASNAPPAPDNGYPEQRHAGAVGYGPEYGKGAGPGDKFQGLFEEAKGKVLRKPDVAQHGRDLRTGMLKQREKEQDNAEDPFKKVDQGDDAAHQVPKDDTDERMAQPPSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQQ8</accession>
    <name>A0A401GQQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0605140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615448.1">
        <property type="nucleotide sequence ID" value="XM_027759647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQQ8"/>
    <dbReference type="STRING" id="139825.A0A401GQQ8"/>
    <dbReference type="GeneID" id="38781452"/>
    <dbReference type="InParanoid" id="A0A401GQQ8"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="480" mass="53188" checksum="DCD3A667C1A79046" modified="2019-05-08" version="1">MSLDDHSSGRFLWDKFIDLLPLVRYIPAEAAVSEASVAGVDGWVKSDLKGVLLEDHNSRCYLCLDDFQQPRRRSSLKLELLDDGEPEPLKQCLCGHVFHRYCIDHWMHENDSCFLCRKILYPPEGYEEDGDWAILFNVVRDEAGTIKRAVNVDLLHIFQFKCSQMWCEQGIVFFACWQHGAVVIDTATGSQICVLGDRGLSSMCLNGDRLALITGDGRGRINIWNLADRRIMNTLLGHSDTLQGLEVSQDGNTLFSVADDESLRIWELPDGNMVKIRSAANQPHSLLCQTNTLSQYPLRQVGHVAFTPDGKGFLTGSDDHLLKLWDLATILDQQEPPVRSIDDAEWPVGAESVVDSTKTFTGHTDNISAVAVSYDGRWVLTGSTDHEVHLWDIETTAVQCLLVGEASVTSVSFCVKGDVFSTCCSDGSVQISRDPPSLARLNNCLMFSRLVPGGPTTSVDQSASHPSSRRFLFPGVPRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRX3</accession>
    <name>A0A401GRX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0701350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615866.1">
        <property type="nucleotide sequence ID" value="XM_027760065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRX3"/>
    <dbReference type="GeneID" id="38781870"/>
    <dbReference type="InParanoid" id="A0A401GRX3"/>
    <dbReference type="OrthoDB" id="3262301at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="21695" checksum="EF6BCDB6A07B2308" modified="2019-05-08" version="1">MLSNVKFRATPEGVPYVVEFSNIKFAPPKSRWSRSSWTSSTTTSSATTSASRISDLPPPPPPKPFPRAKQSGGHNLLIRFGHQNSSERRRPRRLSPRELWDMKRAIADAVTAAGMTSSPVEKHDALGEAISQRQAAIKVAPRNAASGALYAGTYGQMLGAMNSAGLVATEVSDVCGATWLGAIFVPKSRGGNLQFSTLNLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS61</accession>
    <name>A0A401GS61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0702430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615970.1">
        <property type="nucleotide sequence ID" value="XM_027760169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS61"/>
    <dbReference type="GeneID" id="38781974"/>
    <dbReference type="InParanoid" id="A0A401GS61"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="862"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="866"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="983" mass="109520" checksum="FA3C61CE40E38603" modified="2019-05-08" version="1">MAYAAVDPARSRTFSWVSNQLASPPPYEYHDVFPAIPAPVTYSVDPPPNLSSFPKAQDMGGMHADISRASRSRRPAQPLSIPHLREALHSLESEMASLLTQRDLLESKLEQAVRLQSPIQRLPNELLASIFVIGVLDGEEEDSLMMSTLMLVCRYWREVALGTPVLWSRIVAGTRHSLDRVRLKLDRSKSAPLYICVDFSPRMEHGSVTTENIMLAMDLLRPSIWRWRSFQLTILNRPQAHAALTRCKDRAPLLEVLSVRVSHSMQEDHYSHPPLPLFAAYTPNLRSCSFTSFNFNWDLRLVNRLRVLKLGGYWNGFTPSMDVILGMLRACPQLEELALRNMSDVDPDSCATFDTDPPEHDGVPEQLVRVSDSRTIQLPRLVKASFYYSGVRIELCFLDNVSPVVEHLRRQSLTSLPLHHIRIEASFFNELKLVRLLRRLPALITLELVDVEDASSNLMKNLSTPPASQTWICPKLTSLSLEGCTSLDWESLRSFVESRLPAQTRAFPRQLPTSAEPQPTHPSTSSASEFAAHAHILSRVPVTSSANQALTARVWPHRLQSVDLTRCHQISKEMVQWLRMYVAEVKCETVKGREALERATGQVPEAPPEPEIDPWQTESAFGAQRRALAPRFVPAIVSYDEINDKMSETSLGPATRAEQVNTNDVSGWYRSLTQQARSTSAPAVAVAVSSTVTSTISPLASPAPATAASISIAHLAVPPTSQRQEVDRRKSKKDWFISRALQSEPATTRSTPAPTLADILSREPPPLPSERRFAPPVFLALGPTNKGFAMLQRSGWSEGEPLGPGVLRRAVAKESETSRKAKAKKDRQERPIVVKKEEREVKCGDDEEISELREVDVIDLTVSDSEREEAEEEEEVEGESLEDLSGTSYSTFSSHNPTALLTPLPTVLKSDRLGVGLKAKTVGPYKESKKRITHGAAALAAHIRANEEMRRTKKLMGRGTRGFARITKAEAESRQRLLASLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSG9</accession>
    <name>A0A401GSG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0703670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616094.1">
        <property type="nucleotide sequence ID" value="XM_027760293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSG9"/>
    <dbReference type="STRING" id="139825.A0A401GSG9"/>
    <dbReference type="GeneID" id="38782098"/>
    <dbReference type="InParanoid" id="A0A401GSG9"/>
    <dbReference type="OrthoDB" id="3366546at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41564" checksum="606BA2975F6BF22B" modified="2019-05-08" version="1">MPLDGHAYLVAQGWDGMGSGLRQGSISRPVTVAQKKTLSGIGKDRDEAFPFWDHVFEAASINIQVKLHSDSDDDSESTSTSTPAVSLQRTSTGILSNRRPKIGTPAFSGSATPESSDSITPRFGVMAAAKQEAARRSLYSKFFRGPVVGIDDIATAVEAEVDQMVIVTSAVEVLKGVESDEVAVERQRKIKGKTKATDEAADELATEGKRTKRKRKTEAVDELMQDAPQRKEKAKEDAGYKRDKKRRKQHAEEKSSQEEPVGETVGGKIDHAKEEERRRKEEKRARKEGEKARKEEKRVRREEKRMKKTIREPKLDHDTEEATTTVCDHPETSTRNVDSSQRRIRIRKGVEISRSGVADKAKKRRRTSSEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSV2</accession>
    <name>A0A401GSV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616234.1">
        <property type="nucleotide sequence ID" value="XM_027760433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSV2"/>
    <dbReference type="GeneID" id="38782238"/>
    <dbReference type="InParanoid" id="A0A401GSV2"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="166" mass="18785" checksum="DE10E21C86D28364" modified="2019-05-08" version="1">MASAELEAVQIWVISADQTIPLRHSVLWPDHPSSYVRIPEDDLAYHYAAFIPSRDEPVAVISVFKESLPALPVSSSKAAESRETYSNAARFRKFACDPSYQGRGIGTKLLEYVFCTARAELSCGTVWCDARVSTVPWYERRGMTPFGEIFIKSGMEYIRMQRRLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSX2</accession>
    <name>A0A401GSX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616196.1">
        <property type="nucleotide sequence ID" value="XM_027760395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSX2"/>
    <dbReference type="GeneID" id="38782200"/>
    <dbReference type="InParanoid" id="A0A401GSX2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="215" mass="23642" checksum="ED8C0B6EA6187DB3" modified="2019-05-08" version="1">MNQRPTEKTPTLSTNASIHRLATRSKSDLFTNKNSTITDWLSTFNHSIDTSDKALIFLCNNELATAGKAAELKTLTRALVRLAKARTSDTKLMQTLVSLAWYTELIVQEDSTVKAMTSICARLEQYEGKIEKITKTATEACEQAKQGTDNLSNLAQQLGEDVVNIRDTHQSLCTISDNLHGMATDAGQSMRKVTKSFAEAHKPEAAPQQPAKASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSZ5</accession>
    <name>A0A401GSZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616271.1">
        <property type="nucleotide sequence ID" value="XM_027760470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSZ5"/>
    <dbReference type="GeneID" id="38782275"/>
    <dbReference type="InParanoid" id="A0A401GSZ5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="175" mass="19415" checksum="E2CEFFD44F69F96B" modified="2019-05-08" version="1">MACISTYTSHPELVRIDIPAIELEEGPRTVRGRADTNCGKTDESDRWHDKQRHAPHHGALAHTPRELLYSTNTGQAFHRSDTWDPSVSEVHSIRVKLFDPKVPLRFLCQNLTGDGSPTEYHAPSSLLHALALFVCAFYIHHALCPNCRASSPWHHSSQPGISRTRPASGGDAPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTW8</accession>
    <name>A0A401GTW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616536.1">
        <property type="nucleotide sequence ID" value="XM_027760735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTW8"/>
    <dbReference type="STRING" id="139825.A0A401GTW8"/>
    <dbReference type="GeneID" id="38782540"/>
    <dbReference type="InParanoid" id="A0A401GTW8"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="437"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="654" mass="72057" checksum="F08451FB927FD9E7" modified="2019-05-08" version="1">MTKKIAPYGTWTSPITADAILKTPPKVEEVIVDPVTSTIYHIEARPSEKGRNVLVETEKSRDVVGREWDVRTRVHEYGGAPAIAHNGIIYFSSVNDNRVYQVQDGKEPEAVTPDNSNHRFARLAVHPIHTHLLVSILEDHTKPAPLDVVTTLCVINTKTKTISPLVSGADFYSSPCFTPDGTHIAWHQWFHPDMPWEGAEIYTAKVAADENGMSLSEVKYVAGKKKETSVAYPFWVSNDLLLFINDVSGYQNPWKYSVSSGKASPALYTPVQEDFSQQSWQLRHEAGAALDKEGSRVLFLATRDGRTVVYVLTLQSGALEEIACPYISGLVVRHVARDTVVFIGEKTTEPQSIVLCSLKDYSMPHFTILRPPSVGPSFPASYISVAQPMTLRVSPDDRPIHVLYYPPTHPEYIAPEGEKPPCVVNAHGGPTGMATQSLDWLVQFFTSRGWAWLDVNYGGSSGYGREYVERLKGNWGVVDVEDCVAATQQLAKPPLSLIDSQRTAIRGGSAGGLTVLNSLCYHPTAFAAGTSLYGVADLKSLAEDTHKYESHYLFRLIGGTVEQVPQVYQERSPVNNAEKIKTPLLVLQGSNDAVVPPNQAENIVNTIKRGGGRVEYVVYEGEGHGWRRADTIKAALEKELSFYEGMFGLTGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUA7</accession>
    <name>A0A401GUA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0803330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616724.1">
        <property type="nucleotide sequence ID" value="XM_027760923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUA7"/>
    <dbReference type="GeneID" id="38782728"/>
    <dbReference type="InParanoid" id="A0A401GUA7"/>
    <dbReference type="OrthoDB" id="2858653at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24503" checksum="F195D3BF05155193" modified="2019-05-08" version="1">MKPEFTQFLSSMEELSLSFLGIHVLGNLSDVVYGVFWTALFIPRFLMPGQSQLASLSLTSDMPIGQDPPVQFDTLRFPALRSLSLNGVVFDNEERLDRFVMNHHATLATLELNSCPIYFPDTVTLDVPRRWSNLLQRFEAGLQQLVQFRVLLRSGWGLDNLEVFEPAETRLTYVSSLSGFGYPRGGWGDPADDAVRAEDAASLERPLDVLHRRRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUH6</accession>
    <name>A0A401GUH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0803550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616746.1">
        <property type="nucleotide sequence ID" value="XM_027760945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUH6"/>
    <dbReference type="GeneID" id="38782750"/>
    <dbReference type="InParanoid" id="A0A401GUH6"/>
    <dbReference type="OrthoDB" id="2960452at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="538" mass="58847" checksum="7A42EC65D7207386" modified="2019-05-08" version="1">MCVPTVRAIRHTFVAPLHSTSTADTLHHLHSRQCDHHADLLLECQYRAWPTAKHTAPLRVPPPQPSPSHFMTARGLTNTRTSQRANPNAAPSLSHNTCTRSVRIFLCYFAYILLTSSNANTVPRPTKTRACTARAIPHAFAPLSTAPRPLTPSTTYSRQPDHHADLLFECQYRAWAARTSHSNAKATPRPSQSTRLRCVRNFLHTLTPVSGPRPDSECRWTCPNSRTANNSHLTRFPLATATMASVTDAPATTPGSKRKMRHLLPSAPVPSPAKRQKPEDSDDIRLDHVSIATAHDIINLATADPTALHFVTIGASDYLQLKTSTHLMLFSVVGSVTHSDLISPSGRSRQLCVAPSALTWPRAAAVLGAILNRRTLVFPSFHAGLSFSTRLTTGTSNTPTKIRGMAPATPVNAQRGPPPVLPANRDVPTFDGCKPFKFSMRSILILPKIHDDLSTESAVLLLFTLGKYIKSHPELDDENADTTISLNIQSIVLLANPGLMPRGFLEDEPMPLLGVFRPNSEPDQHHSDDSDDDDASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUJ5</accession>
    <name>A0A401GUJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616820.1">
        <property type="nucleotide sequence ID" value="XM_027761019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUJ5"/>
    <dbReference type="STRING" id="139825.A0A401GUJ5"/>
    <dbReference type="GeneID" id="38782824"/>
    <dbReference type="InParanoid" id="A0A401GUJ5"/>
    <dbReference type="OrthoDB" id="2784932at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="1">
        <location>
            <begin position="147"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="256" mass="28380" checksum="6421F5A166D6F9E7" modified="2019-05-08" version="1">MCWITWSGNVKGTRKRKDAPQVRSVVTEAALGCIRDAVHLPPVVRVAAHAALLLSNKYYALTDECEAYRISIVMCPDKKLDYFMKRGWSPEDVEDAKKLVIKRWEETYKPSLGVTISVAPALVAMRGSEWLTPAVVEPVRPIDSIYTYLEDPVLSASAIQLIGGVMEYWYNAEQCTPHLAAMGSDFCSAPTSSTDAERAFSDGRREVNFMQHNTLSQTFKASMAVGSWDGTPLLPDFPELTQLMRAKLRGDAGLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUQ6</accession>
    <name>A0A401GUQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0804890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616878.1">
        <property type="nucleotide sequence ID" value="XM_027761077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUQ6"/>
    <dbReference type="GeneID" id="38782882"/>
    <dbReference type="InParanoid" id="A0A401GUQ6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8222" checksum="B51BE9D85B4603E1" modified="2019-05-08" version="1">MRFRPSDVVEGIFGRVLTRATAKDLISSLALFDPTIRVIVSPFLAIGPPSVCWFLRIDSSKDGMKPKLCISPACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUR1</accession>
    <name>A0A401GUR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Docosahexaenoic acid omega-hydroxylase CYP4F3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0804950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616884.1">
        <property type="nucleotide sequence ID" value="XM_027761083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUR1"/>
    <dbReference type="STRING" id="139825.A0A401GUR1"/>
    <dbReference type="GeneID" id="38782888"/>
    <dbReference type="InParanoid" id="A0A401GUR1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="549" mass="61241" checksum="AB5C9360F1AF8AB8" modified="2019-05-08" version="1">MFTSVLQSVLICAVIWISWRKVLRHFVMKSPFNNLPGPPSQSFWTGNIGPFVNRHGWDFHLDVARNYGRVVNLKGFLGEPTLYVYDPKALHNIVVKDQYFYEEPRSTLQFNHLLFGPGLLATLGDVHRKQRKILNPAFSVAHMRYMLPIFYNIANIPVLQIAIASRVANGPGELDILGWMGRTALELVGQGGLGYSFDPLIEDASDEFGDALKTIFPVTFSLGLVRYALPYLMQLGPASLRRRLVGLIPNRRVQRIKSAVDTLEKRSREIFDAKKAALLQGDEAVMHQIGEGRDIMSVLIKANMAAKSEEDKLPEDQLLGQMAILTFAAMDTTSNTLAQILQYMALRPDVQDKLRTEIIEARNGGELSYDALMQLPYLDAICRETLRVHPAAPIIERKANKDMILPLSAPIRGVNGEMINEVPVPKGTRIFVGVMGSNLSKALWGEDALEWKPERWLSPLSTALTDAHIPGVYSNLMTFMGGGRACIGFKFSEMEMKVVLSVLLPSFTFDITEKPIVWNLAGVRYPTIGAESLKAEMPLKVGLFKESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV33</accession>
    <name>A0A401GV33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-type alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0806210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617010.1">
        <property type="nucleotide sequence ID" value="XM_027761209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV33"/>
    <dbReference type="STRING" id="139825.A0A401GV33"/>
    <dbReference type="GeneID" id="38783014"/>
    <dbReference type="InParanoid" id="A0A401GV33"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="349" mass="37565" checksum="0A736C675AFFDAE6" modified="2019-05-08" version="1">MVMPLPQTTRQYYLPKFDGVHNLTMREAVVTPPKHSEVLVKIHAASLQFRDLLLAKGKYPVPAIKENVVPLCDMAGEIIAVGDEVEEWKVGDRVCANFWVDHIFGEFKSGYLLSALGAPIDGVLTEYKVFPVHCLVRAPDHLSYEEASTLPCAALTAYTALQGSIPAKGGDTVLIQGTGGVAIFGLQFAIALGATVIATSSSDAKLKVAARLGAKHLINYKTMPDWDEEVLRITNGRGVDHVIEVGGSGTLTKSLNSVCYGGSVHVVGVVAADGDISTLPQQVMLKNASLHGVIVGSRVQFEAMNRLISANLIKPVVDKVFPFEDAQKAYEHLDSQKHVGKVVIKISKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVB1</accession>
    <name>A0A401GVB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617080.1">
        <property type="nucleotide sequence ID" value="XM_027761279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVB1"/>
    <dbReference type="STRING" id="139825.A0A401GVB1"/>
    <dbReference type="GeneID" id="38783084"/>
    <dbReference type="InParanoid" id="A0A401GVB1"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="115" mass="13481" checksum="F8BE14499094B688" modified="2019-05-08" version="1">MSRGRGYSTRAWWPRQQQRHEFQRRISRRWQRRRCSRRRELSAVYATVVVTALAFPNNSVSLIFLPGLYFSILWGVGEMVVIDVMGGLRGWALFERYAHLGEAAFGTYYVCMASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVI4</accession>
    <name>A0A401GVI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0802860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616677.1">
        <property type="nucleotide sequence ID" value="XM_027760876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVI4"/>
    <dbReference type="STRING" id="139825.A0A401GVI4"/>
    <dbReference type="GeneID" id="38782681"/>
    <dbReference type="InParanoid" id="A0A401GVI4"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="434"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1230" mass="139029" checksum="ACA61190C07D6F92" modified="2019-05-08" version="1">MEIFMRDIAFATSQQDLKVEFSKVLHNPPFPSQPPLNFEVDIFKRNPNWRGKCGILALPTEEAGKIFLRTYGSAGIIVNHRRIYFKVSTKEINRARIQMLNSNPWRDPLQLQQEKDRRIQESKPFPLVRYAFGRFLPDGSFSAEIFLPGTASISCQGVDRRQVRFEFRPSQEPIHGDLGGLMAMLNLDNLFDTCVAALYTPSKIEALFESRAEHPPVVFFRTNSPPVFLAESSSPLFGGRPQRLRGLMRDQPMPSGCHSLMLVFNPGSDAEDFVHACRSRLHLDYSLKPRISVRDNLFSPTILQDLDKFLSDLQFELAFEVEKTITRSILSALEVLAMEREIADLQREYGRQASQIFQAFASLIEEGGTSGRKRRRHGKSVGLPEDYQAVLTSLLHQAIQHFVEEQQRPRPVLSLVLVEATAAAAVYLCYHLILTPTRYILEGPLPDQSNSVLRRFGHHESFLRVSFQDENQTKLRRDTEFSIAELLRIRYRPILLQTGCRVAGRPYELLGHSMSGLREHSVWFVSPFVDRNGQLQNAESIRNSLGDFSRKQGQPSLLLHQPARLSARWAQAFSATDPSVTLRPDEIDLEFPDKISETGQLMTDGCSPISVDLAGLIWRSMQKGKRRPAKLQDVPSAFQFRLGGAKGVVVQDPSIPGRHLRLRPSQIKFDAPNNLTFDVQSTSLRPKAMFLNRPLIVLMEYCQVDSERIIQLQDDAIHRAQSVRSSFNDASKVLQQHGLGASFHLPSLFRNVSSILRLGMDGIEERDRRWDNELVESALHCAETHILRELKYRAHIEVPGSYTLLGVSDEWGCLREGEIYATVRDPKTGKLSPITGSVAITRSPQIHPGDLQVVEAVIRPELKHLTNVVVFSCEGQRSLASCLGGGDLDGDDFNIILDPKLIPRTVKRPGAYEGLPIKTTAHECGIADVVDFIFDYIESDLVGYIAISHLRFSDLKDPSCDECLQLAKFASHAVDFPKTGTPVNFTSLPRFAKDQPKPDFLAREGNDLQSDRYYTSNKLLGILFRRVPVKKWYPKLWNENYSPSGGTVVETALSSIHLHSLGLPAPNEPSEELLEEMRHLLDAYCDQLFAIAKVHTITKNKDAYVSEAELMSGTIMANWSDHRRRRDAVSAMNLQTSGLVRAVRAEFRPSELAAANEEDYEEEDYEDWTFREVFDEEETLMMSETFKRAWAAWYVAEDALAEYPDAFGPQSFGLIALGRMLEIVKESLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW39</accession>
    <name>A0A401GW39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0903260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617360.1">
        <property type="nucleotide sequence ID" value="XM_027761559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW39"/>
    <dbReference type="FunCoup" id="A0A401GW39">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW39"/>
    <dbReference type="GeneID" id="38783364"/>
    <dbReference type="InParanoid" id="A0A401GW39"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="336"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="405"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="467"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE86447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="775" mass="88242" checksum="51821D13E35DD97E" modified="2019-05-08" version="1">MSASTSSTSPPGPLRNRRHVTALDSPRAVEVDDDRDEHLADYHVKNRSYIEILLESEEASMVVVAVLTALSFALRFYKINWPDQVVFDEVHFGKFASYYILREYYFDVHPPLAKMLFGLAGWFVGYDGHFMFENIGDSYLENHVPYVGLRALPAILGSLTVPIVYAIMKECGYSTVVAIFSASIILLDNAHIAQSRLILLDATLIFFMSLTLYSYIRFRKLRFLEFSPEWWGWLLATGTFMACTWASKVNGVLTVVAIGIAVLVDLWDLLDQRNSMDYFWKHFMARAVGLIVLPIFLYLLFFYIHLSILVKTGPGDTFMSPAFQETLIGNELLLNSQEIRYYDTVTIKHKDTRVFLHSHPEVYPLKYEDGRISSQGQQVTGYGHDDSNNNWQIIPTKALPETGRGRIVRHDDVIQLLHVNTQSYLLTHDVASPLMPTNEEFTTWPKDDLSRYNDTQFELRIVDGHEGDSWKSKSGHFRLIHVPTKVAMWTHSKQLPEWAFSQQEINGNKNVNDKTAVWFIDNIVADETGEDLRQRTGDIPPKPPKKMNFFKKFAELQLLMLQHNAGLTASHPYASTPINWPFLLSGISFWTESNDQKQIYLIGNLIGWWMCVVSLSIYVGIVGGDLVMRRRGENPLSDPVRNRMWNSTGFFFVVWAVHYFPFFLMSRQLFIHHYLPSHLASALVAGSVLSFVLSEEVNYPVSTRGPLLLHPKQARKADLGVKGPVVVGLSILLLLILFVYISPLTYGTPGLDGDAVNRRRLLSGWTLHFAGKPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWD4</accession>
    <name>A0A401GWD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0805980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616987.1">
        <property type="nucleotide sequence ID" value="XM_027761186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWD4"/>
    <dbReference type="GeneID" id="38782991"/>
    <dbReference type="InParanoid" id="A0A401GWD4"/>
    <dbReference type="OrthoDB" id="2745718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="30674" checksum="7CDD799B47494CF3" modified="2019-05-08" version="1">MSVDLQPTATPEILVEIPSAVAYHVLGDSTALLGEGELALVLTRLSGVSAPPAPAPGGVSRTPVLALTVGRAAFPLFEDTVFGTLAGDQRAYVFTPEIGGERGGYVKIALPEGVLVEGSSLSELHTQFEQVLIFYGLLKEGVEAATDESRKNVRDDYANGGQGTRDSTTSHLSENSPTTSPAHVPASVATALPSSTSGTQSVVITTRRVTNAVTSAVGNAGARVAGHLSQSSPSKSQDLANAYYPDAAEATEIQGTVTDAVVGMQFHEQETHDLQDVQDIVDAEDAEFWKEVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWP1</accession>
    <name>A0A401GWP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0904680</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617502.1">
        <property type="nucleotide sequence ID" value="XM_027761701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWP1"/>
    <dbReference type="FunCoup" id="A0A401GWP1">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWP1"/>
    <dbReference type="GeneID" id="38783506"/>
    <dbReference type="InParanoid" id="A0A401GWP1"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE86589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17589" checksum="04A46829740A9AE6" modified="2019-05-08" version="1">MSTELPYAADAEVSLSYDELEVLRIQFQKEVAQSHVTVQTKFNYAWGLVKSPVHDHQVEGVRLLQDIYRTEPSRRRECLYYLALGHYKMGNYEEARKFNSLLMEKEPTNLQAQSLAMLIDKRVARDGYIGMAIAGGVAALGTLLVASLVRRSSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWV3</accession>
    <name>A0A401GWV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA helicase Pif1-like 2B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0905420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617575.1">
        <property type="nucleotide sequence ID" value="XM_027761774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWV3"/>
    <dbReference type="STRING" id="139825.A0A401GWV3"/>
    <dbReference type="GeneID" id="38783579"/>
    <dbReference type="InParanoid" id="A0A401GWV3"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like 2B" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE86662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="187" mass="20165" checksum="3BCE229A035E36C8" modified="2019-05-08" version="1">MAPQRLILKIGAQVMLIKNIDETLVNGSMGQVVKFLDPSDPNGSLDDELPGGKPLSKNGAAKPAKKAAEVTPWPVVDFLGPGGSRRRVVVQSESFKVELPSGEVQASRTQLPLILAWAMSIHKSQGQTLERVKVDLAKVFEKGQAYVALSRATSLDGLQVLHFDPAKVNAHPKVVEWSKTLETVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX65</accession>
    <name>A0A401GX65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1000680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617739.1">
        <property type="nucleotide sequence ID" value="XM_027761938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX65"/>
    <dbReference type="STRING" id="139825.A0A401GX65"/>
    <dbReference type="GeneID" id="38783743"/>
    <dbReference type="InParanoid" id="A0A401GX65"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE86826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="369" mass="40581" checksum="6B4BA3CD88BC9225" modified="2019-05-08" version="1">MNGWPISSGRANSDVIYVNAAGTPVIVLNSAEAAYDLLKKRSSIYSDRMRMAMVNDLIGANWFFTFMGYGQDWRVRRQAFHQEFHPAAAVKYRPRQVKVARELLRHLLADPDAFLEHLRHMSGALIISVVYGLDVPPKDDPYIAIAEKANHALIMAGNAALTLLPSETHTDMVSRGPLQAPSVGVEKANDGHDTGSVPAVKEAIADGVASPSVAMSLLSKLNEDDNYTEYEYVYRGVAAAAFSGGADTTLSALGSFFLAMVLYPAVQRKAQEELDRIVGRDRLPEFSDEPSLPYVTAVIRELLRWRPLAIPHRLMVEDVYRGYRLPAGSMVVGNVCSVLASFDIMKAVDVDGKEMEPTGEYSTGIIRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXN1</accession>
    <name>A0A401GXN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1002320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617899.1">
        <property type="nucleotide sequence ID" value="XM_027762098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXN1"/>
    <dbReference type="GeneID" id="38783903"/>
    <dbReference type="InParanoid" id="A0A401GXN1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="204" mass="22937" checksum="31E12C56054976F4" modified="2019-05-08" version="1">MRGIVDTTPNPSLRHSSSQRRILTQLQRPFTPASLRLSRRVHPHRSPSPAAHLHRSPHPHPPHRSHSSYMRGQLSELRTRRFLCAQATAHNPFQPPLHTPDTPPSRWPWRAVPPSMLGPAATPLDAFWPDGAFHLRALRARALFRRGAQSVQTPNPVSGWAGVEPARWLHDVTPAKCLRSEHDAEGLCILRDLPPGHADEDKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXX0</accession>
    <name>A0A401GXX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1002890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617955.1">
        <property type="nucleotide sequence ID" value="XM_027762154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXX0"/>
    <dbReference type="GeneID" id="38783959"/>
    <dbReference type="InParanoid" id="A0A401GXX0"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23724" checksum="3C932397E960BAA8" modified="2019-05-08" version="1">MLQWIAGTAHMIMRIKRRLVSNLSVSSRTALTLVTGAFTGSDDEYYAQGNRRCGVRLFQDPYNPDSEAMKFPCPFPGCTYRTLQAGNLKPHSLKQCVLAPTVHQSLLSLTDPDATAQLRCGPSMSDSVNVYGAFIGDSIDFFVPSASLELLEGHPTDVFYGSHTAQDLSNHSAVPSQVNGKLKESYCTLAYISRAGFSTENFQNQGDFVGVGDPNRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYD7</accession>
    <name>A0A401GYD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1004590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618125.1">
        <property type="nucleotide sequence ID" value="XM_027762324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYD7"/>
    <dbReference type="STRING" id="139825.A0A401GYD7"/>
    <dbReference type="GeneID" id="38784129"/>
    <dbReference type="InParanoid" id="A0A401GYD7"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="133"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="439" mass="48193" checksum="F0648039BAC72F14" modified="2019-05-08" version="1">MGILVEDFASGKNTTALPHGIQTFTWDTKIRELFPDGEWELADAWASQKANLRDVLTHVSGLPRHDFSYSFQDTSLDVVKRLRYLKPAFELREQWYYNNQMYVLGAHIISKYAGVPFSSCGRGTTQLKLVVAGPGGVVSSTVDMTKWLAMLLHKGVDPRTNLTVIPKAAYEESTTAHSVSLGKPSSPITSLIGYGMGWMRLSYQGRDMVMHTGSLPGFQTLVAFMPSDKLGIVGVENTDDPSGTLSAVPLRILEDLLGLPHSIPGILAQSSKFTTYPPPLRSTSLAFEDPIPATVALEEFTGTYVNAGYGNFTLCTPASVSAYCRQVLNDYAAVRNVSASDLPSALYAAWPRLWSSKLRLHHSSNMTFKLALESLFVDGYGRDRTPFVYSITEGADIEVECALHDGRVAGCGIMHGLDEFKTPPEGTMEERADVWFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYK9</accession>
    <name>A0A401GYK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1004920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618158.1">
        <property type="nucleotide sequence ID" value="XM_027762357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYK9"/>
    <dbReference type="STRING" id="139825.A0A401GYK9"/>
    <dbReference type="GeneID" id="38784162"/>
    <dbReference type="InParanoid" id="A0A401GYK9"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018986443" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="872"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE87245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="952" mass="100004" checksum="1245B4B82C1D08FC" modified="2019-05-08" version="1">MRLRLSPRFAALAAVVSAATGVTAQSSAASSSSAVSSAVSSSAASASASVLSSTSAVSSISSSVSASVSGSVSASSSDASPPASSSAASASASSSAASGSASSSAASVSASVSASASISSSLASAPSTSAGSASASSSSSSSITTAPPSSSSTVAHTVGGSYNSGSGTESGWLTWPISSYTFASFPVVTQTPIPGVYQVSSPSEPPPVDNAGACVVPDFDYAWGAAYEQAEAFVAGLTVEEKVNVSTGVGWENGRCVGNIGPVAGFGGLCLEDSPLGVRDTDFNTAFPAGITVASTWNRTAMRLRGLQMGQEFKGKGVHVALGPMINMGRVQQAGRNWEGFGADPFLTGEAAYETVLGLQQAGVQACAKHYIDYEQEYKRTQESSEVDDQTEHEIYLRPFLRSVMAGVASVMCSYNLINDTYACENDRTLNQLLKGELGFRGYVMSDWGAQMSTLAAVAGLDMSMAGDIYLGSGTSYWGQNLTDYVNNGTIPLSRLDDMATRIIASYYFLDQAYWYPNVSFNAFYPYDETQNLHVDVEADHYKLVREIGAQGAVLLKNTNGALPLNKPRSIVLIGQDAGDAPMGPNGYSDRGGDDGVLAMGWGSGTDNYPYLISPLDAIQERAREDGTTVSWWLLDWNTAGAAQAAVQFDAAIVFANADSGEGYITVDGNTGDRNNMSLWNNADNLISAVAAVNNNTIVVAHSVGACIIEDWVDNPNVTALIWANLPGQEAGNSLVDVLYGAVNPSGRLPYTMAKSPSDYGTSLTGGGDASTIISIPYTEGIFLDYRHFDTYNITPRYEFGYGLSYTRFGFWNAAATRVPGYDWEYSGLEQEWDDGVPTPDVEGASVAIYLHRPVIQIQFEVQNLGDIPGTEIPQVYVHFPPAAGQPPSQLKGFDAVYLWPGEVQTVTISLSRYDLSVWNVAAQGWQRPAGTFAYSVGASSRDFRLNGTLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYR5</accession>
    <name>A0A401GYR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1005560</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618221.1">
        <property type="nucleotide sequence ID" value="XM_027762420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYR5"/>
    <dbReference type="FunCoup" id="A0A401GYR5">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYR5"/>
    <dbReference type="GeneID" id="38784225"/>
    <dbReference type="InParanoid" id="A0A401GYR5"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="202"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="562"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="787"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="705"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="955"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="736"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE87308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="980" mass="108593" checksum="D3563E8F961ED0F8" modified="2019-05-08" version="1">MSPSKAPGAKRQSRVLAALDNPAFFSPDPAAAVPPVPSQSTLVAPIKRPIEPPPELLGTQKRRRTERENVPGSAMDGVTPAGAQLLSQILGTQPRGSQPSHSGGSGAPPVVVGGVIGGIAGNGFHLRYDAEAPVHRIDMGGQDQNMRMAEFVTRTIDNASHGITVKAAMEKLGLHDARDLLPGLEVRLLPHQAIGVNWMLDQERNTPHKGGILADDMGLGKTVQMIATMAMNQPGEGDTHRSTLIVVPAALLLQWKEEIESKTNGMFSVHIQHGREKIKSLPKLAEKDVVITTYHTLNSDFAVPSDVESSDEMDWIVTNGGLMARMKWFRVVLDEAQFIRNRSTRSSKAVAMLRAKYRWCLTGTPVTNTLADIYGLIRFGRFRPWNDWEDFNAYIAKVQLEDAPLAGLRAQEVLKPLLLRRTKDAELEGRPLLQLPEKHIELVTLEFSEEERELYDSFEKRAQIQINRFIRENTIVKNHTAVLVLILRMRQLCCHPHLILSLTEGFEDPTLLVGSDADKEIARANKLLGAQWVMEVKKRFMARARAAQFDFGDEDDETEPTCPVCGDLFMNDSGRLLACGHEICNDCLDALGTAPIMHDGEFGLGDEQTNLRIEKEFEAAAAKGLRPCPTCKKMNDLRPTHVFRASAFEPAADEVRMAMQRAREARRRAAPGPPKRVVRRSEVEELIELSDSSDEDLPDISQLLAREGNKKGKGKGKGKRVVSDDSDAEGAPAAKVKKETRTDKGKGKGRSRDWDSDDDAPRKVSGDLLATWNRGDNNMEPSTKMLALIELLQEWEATGDKTIVFSQWTSMLDLVETLFARYGIRSLRYDGRMGREAREMVLAQFRKSGGPRVILISIKCGGVGLNLVSANRIINLDLSWNYASESQAYDRVHRLGQEKEVFVKRLVVSNTIEERMLQLQETKVGLAEAALGEGTGVKLHKLSVKELKDLFGMSKNPNNNAAGNRLRQTRLDANLDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ10</accession>
    <name>A0A401GZ10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxysterol-binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1100700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618307.1">
        <property type="nucleotide sequence ID" value="XM_027762506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ10"/>
    <dbReference type="FunCoup" id="A0A401GZ10">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZ10"/>
    <dbReference type="GeneID" id="38784311"/>
    <dbReference type="InParanoid" id="A0A401GZ10"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="532" mass="58548" checksum="92124C8D4A65614E" modified="2019-05-08" version="1">MADHDDNVIPQDEDVSTQPIAVPDSADGESGKLKMILQLLKKCLGVKDIAAMRLSLPASLLEPIPNLEYWHYLDRPDLFAAINDSDDPFERMLAVLRFAFSKDIKFIRGRVVKPYNSVLGEHFRSHWDVIPVAYSSDPLQPPIQHLYLTPAAAESSYSTIAPTPKSETASIRSGKSGKSGMSTLSGLSALTSTSRGYSTPGKSTPGTSPSIGETDIDAAMSNLDLVDSSASSRTDLIEAGEAPAEAEHERVRVVFLTEQVSHHPPVSAFVARCPSRHIELRGVDQISAKVSGTALRIIPGSLNKGLFVKLTGGADAGETYHITHPVGAVNGMLRGSFYVTMGEATIITCSGGAEGKKLRAIIEYKEESWLGRAHFLVEGVVHEYSPGETQHLEWTRVKHVPQSCVVATFDGSWKHLIRWRRVDSTENATLIDLSTLHAIPMSVRPLEKQHPRESRKLWENVTSGLLKKEYSEATKHKLFIEQRQRDEAAERKRRGAKFIPQYFESDIDSGYPTLTAEGQKAVEEELEEEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZF4</accession>
    <name>A0A401GZF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1102090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618445.1">
        <property type="nucleotide sequence ID" value="XM_027762644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZF4"/>
    <dbReference type="GeneID" id="38784449"/>
    <dbReference type="InParanoid" id="A0A401GZF4"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="97" mass="10698" checksum="E99C4BA5D146AC55" modified="2019-05-08" version="1">MSTPIPHPSPQGSCRLAELVQYKCELEVSNVGVSQYHCWPIMRIFRICPGRPAVELTRFAEVNADTGEISAPPESSAKLPKGKPWRDIVHNELKGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0A3</accession>
    <name>A0A401H0A3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1200660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618754.1">
        <property type="nucleotide sequence ID" value="XM_027762953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0A3"/>
    <dbReference type="STRING" id="139825.A0A401H0A3"/>
    <dbReference type="GeneID" id="38784758"/>
    <dbReference type="InParanoid" id="A0A401H0A3"/>
    <dbReference type="OrthoDB" id="3218226at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18689" checksum="81D92EF42D7D5042" modified="2019-05-08" version="1">MHELARQQMADRVRQGSPKFTLGQKVWLDSRNLKVNYASRKIAPKHEGPFEIIGVIGSANYRLRLPKTWQVHSVFHAALLSPYRENDIHGPNYVNPPPDVVDNEEEYEVEAILNHKAYRGHLRYLVKWKGYSSAENSWEPAHNLQNAKQTLDAYKRMRGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0B1</accession>
    <name>A0A401H0B1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1200760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618764.1">
        <property type="nucleotide sequence ID" value="XM_027762963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0B1"/>
    <dbReference type="STRING" id="139825.A0A401H0B1"/>
    <dbReference type="GeneID" id="38784768"/>
    <dbReference type="InParanoid" id="A0A401H0B1"/>
    <dbReference type="OrthoDB" id="432528at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019535412" description="Galactose oxidase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="680"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="733"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="884"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="975"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="884"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="927"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1016" mass="107006" checksum="21BBAAE4E495A0FD" modified="2019-05-08" version="1">MGAILRAFTVLSLVYEFCSAQYAPISRWGQATALVEDIIFVIGGRTDLYNSYSYTSAPVNNDVLSLFLSSSFNISSPPWDYVAGCSNCSSSQAPAVVWHTLSAVNTSTLLLFGGDLGTTAPVPESADSAALVGISSAQTPVWYLEADSWADEPMRRMYHSSSSSGGKIYIVGGLKTDGSNNAYSDHYVFDPKTPSFTQLPSTNGPPDIYGHASIVLSNGWLIVFGGYCQSENTLLPFTTVWAMDTTQSTLGWATLSVSNASVPSPRRGFAATLLEGGQVVIHGGADAEMQTTLSDGWVLDTTRSPMVWSSIDTLSQLGPRRDHFAVGLGSQVLFGFGYANNGAAPAALELFDLPSASFVSTYTPSSSVTNPTSHTIPGPSPSRTGQASSPTGSSDPQHSGSGSGSGGASGTAGDDPPSSTGGANSGGSGSGGGSSGNGSSSGKPSAHSSHASTIALSTVFGVLGLIAGTTAVTWYVRRQLAQDRFHALRGSDNESSPDVLVAGREKALPHVVQNVKSKLGALVPGRPLPQQERRDMLADEDAVPWYNVRRDTSSGQSSSSSGAPHRHHGIGDSLSESLASLRSVGGTMLAYATGSRGLKSREASAGSRSTAWWEENSYTPVADDVGLINGAPVGRAARPRGGRQASEATIGTSYSHYENPFADYDVEETKAGGDIDLDIADHGFPSLSDPPPPPLANIKVPPTPVNVTRLSPLSEHPSVATISNPVTTSDSSLLTAFNAGPSSTDHSSGSAETSRSLRPRPSSILDANPSPTQPMRRSDSWWTRFAKTPLLDRRLSVGSRRDSPRPLDFRDPNPPPRLIPIEESTHTYPDSPPSRQESGHVRARLYSNTQHGRSASSLQTSKTADSEMIEKMGRTMDIAMNSTLTSHASGSGTDSQSYSDADAPQRQLSLSQSAMFPASGDDEVLNPVQSPMETTEAEASQSRLPALPGHPQVSPPKRLAAGGNVAARVEAFERRMSQQEDTAPLRIRKDRPSTYGVVPKPSLFVANPDQRRSDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0C6</accession>
    <name>A0A401H0C6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1200640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618752.1">
        <property type="nucleotide sequence ID" value="XM_027762951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0C6"/>
    <dbReference type="STRING" id="139825.A0A401H0C6"/>
    <dbReference type="GeneID" id="38784756"/>
    <dbReference type="InParanoid" id="A0A401H0C6"/>
    <dbReference type="OrthoDB" id="3250101at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF440">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18814" checksum="C342394446C55424" modified="2019-05-08" version="1">MDDFLEENLRKGYIRPSKFPMASPFFFVGKKDGALRPCQNYRYLNEGTVKNAYPLPLISELMDQLKGASIFTKMDLRSGYNNVRVKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPVTFQMMMNALFKDMIDEGWIVIYMDDILIFSNNLEEHHVRTRRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0G4</accession>
    <name>A0A401H0G4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SCP_1201050</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618793.1">
        <property type="nucleotide sequence ID" value="XM_027762992.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401H0G4">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0G4"/>
    <dbReference type="GeneID" id="38784797"/>
    <dbReference type="InParanoid" id="A0A401H0G4"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="743"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1304"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1333"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1370"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1406"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="464"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="566"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1252"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="149"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="328"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="405"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="832"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1548"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="447"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1548"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GBE87880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1569" mass="169137" checksum="473A9722D930DFD9" modified="2019-05-08" version="1">MSLNDNGPDNIPSIVTTDLSLDPAPPRTPSPHPYPPPSPSLSPSSSSPHNNPSPLFLSPSPILRSPIRPRSSLDVPPHPGYSPTLSPRSPSPSYASSTDDRASSSSHPPPSPTLSARSSVHFANTSLALRDNKPDSGFSSLQLLSADYHHTHSRRKGSVSSAISMSSHAETEPDPHGTPYGLVTLSNPWGTAHSSPSASPTQTHFEASESEDVDGTTVLSHSRSRSYSRRKLSDAQRSSPAHSPTASVHVAPDADAPDAENRPELDLTQDDAIDPAPFAFKPYALASLVDPKNMPALQDMGGVHALLRGLGTHAKFGLDARALQHASHEHEHAHWHERHASERTEDTATSRAGLIAPQTQKAQDDRPGAGIGAGLGASQRHDRNTRAGIGVGETDAVPGIVVTAPASEGGSPLASPAAVDDGASTRCGDEEPEGSVWKEATGTSTEGEERSMEEGDEKAYTAPIDERRRVYGVNVLPTRKTKSLLQLMWLAMKDKVLVLLSIAAVVSLALGFFQDFGTPRPPGEPPVDWVEGVAIIVAIVIVVLVGSLNDWQKERQFQVLNEKKEERGVKVMRAGVEHVIDIKEVVVGDVALLEPGEVVPCDGIFLSGHNVRCDESAATGETDAIRKAPYDDCLAIESAHHDHDTHTDCFIISGSKVLEGYGRYVVISVGTKSFNGRIMMALRGDSESTPLQLKLNDLAELIAKVGSAAGLVLFIALMIRFFVQLGTNNPPRTANQKGIAFVQILIISVTLVVVAVPEGLPLAVTLALAFATKRMTRENLLVRVLGSCETMANASVVCTDKTGTLTQNAMSVVAGTVGVHCKFVHHLEDNRARTNASEAPVREDLGGALRAGPSSGSDTSMRKHTQDFSIDQRQLNDVLPPSLRELFNAAIAVNSTAFEDTDQETGRLAFVGSKTETALLGFAKQNAWEDYKRVREGVSVVQMLPFSSAQKAMGVVVRLPGPRPRWRVYLKGASEILTKRCTRYVVVRHDGGSAEVDEVETQEIDELASDNISRTIIFYANQTLRTIGLCYRDFDVWPPPGAEYVDEDEVSFDDLACELTLIAVVGIEDPLREGVREAVADCHKAGVTVKMCTGDNVLTARSIALQCGIFTSGGIIMEGPFFRKLNRDDLLEVVPRLQVLARSSPDDKKLLVETLKDLGEIVGVTGDGTNDGPALKTADVGFSMGIAGTEVAKEASDIILMDDNFASIVKAIMWGRCVNDAVRKFLQFQLSTNVTAVAVTTISAVASASESSVLSAVQLLWVNIIMDTFAALALATDPASPALLDRKPDKKTSPLFSVDMYKQIIGQSVYQIIIVLVFHFLGKRVLTSDSNNAVQTVVFNLFVFAQIFNSMNCRRLDNRLNIFEGMLNNYYFMGITLLEIGVQILIVFVGGAAFSVTRISGRDWGISLALGVVSIPLGALLRFIPNAPVERFLKAIRLMSNPEVLPTTRPDTEWNSAIELVRDNLNTFSHVRGGRMRASSYVGKSRKAHAPPQSRVPLSSIMTMVPTLVASSIGAGWAPQSPSGLSDPARFDPSKSSAALWEGRIQFHPDTKHDDPAFKRWGSIARHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H181</accession>
    <name>A0A401H181_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1203830</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619066.1">
        <property type="nucleotide sequence ID" value="XM_027763265.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H181"/>
    <dbReference type="GeneID" id="38785070"/>
    <dbReference type="InParanoid" id="A0A401H181"/>
    <dbReference type="OrthoDB" id="3268967at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="676"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1455"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1471"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1529"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE88153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1810" mass="202232" checksum="E4B3F047279EC684" modified="2019-05-08" version="1">MDLQGPFDLSITGYCYALTVVDDYSRKGWKAFLKVKSDATSEIKDLITRLETFSDKKVKIVRSDGGGEFIGNDLETYFKSKRIKHETSTSHAPPQNGVAECYNQTTHEHALCMLQEANMSSAYSHLAKLSALRRSPSIPDLLGTRSRSRLSHLVVPPPTDVEYNDNQHTASALSSLTLTPLSELLDLLANALKEDPSPSIPSPHESLQDPSGSQSHTQQLPNTGSQLDADLITPSAISTPISSAPRLTIDHQHTESNSLDSSADLPAYTHPIQSKMDSTKMGRPIASVTQHSIKQALTISTGKLTPSVLLQWESTCIQYFKKKSVPDDEKVSHVTGGFMDELVRNWYLSDSDTIDALKWPDFVSLMQKCWLNKNWEDAALHQLICLCQCDDEPFEDWIISLEKQNALLRGSPLRMDTATHVHISANACEEICLECNKPVYRSLSDFKDWKDAITAFDNDHLADYCPTWHNSKLRAVLPKLTDSDHALLDKYEGCYKCRRFFIKCKKNNCLNDFPDAATYQPLTAAAGFAAKKAHDSGRSHVAVVTDGDNIDEHLITAVNVTPDSPLAAASCVLGTGDDWVSDEYVLADLTIPHLVCSPSVLIRDDLVKCYHLCRFKLKTPFPLDLFLDDLPHIDELPTDVYHHFRLKDPNLVIARRQYECPKKYRESWKILLQQHLDAGRMHLSSSPYSSPCFLIPKADPTALPRWVNDYRILNANTIPDIHPLPSIQEILSDCGHRKIWGKLDMTNSFFQTHVHPDDVPYTAVATPFGLYEWTVMPQGCQSAPATHQRRMFTALCPYIGSICHVYLDNIIIWSDSLDEHRRNVETILFALRSHHLYCSPKKTDLFCLELHFLGHCISRAGMEADDSKVDKILSWPVPSSASDIRSFLGLVKYISNFLPALSQFTHILNTLTTKEAEHNFHWSSAHQDAFTVIKSLIVSCECLTVIDHQNMGDNKIFVCSDASDWCTGAVLSFGPTLESARPVAFDSIQLKGPELNYPVHKKELLAIMRALKKWHVDLIGVPFTVYTDHRTLENFTFQKNLSRRQARWQKFLAQYDFNIVYLRGEDNTVADSLSRLPPPLAPLAPELTPIDPTTIASLPLFWCAARGLSSICTPPLIPPSDIFTHVATTHLCVATDPDWLTRIHAGYHEDKWCSCLLLDLAHTDSIDSAAELFTAGKLDGDRLIIPRVTDICEGLFCLAHDSLGHFGFDKSVAIDFIGLLPEDDGFNCIVTMMDRLGSDIRLAPSHTDISTEDFTALFFEKWYCENGLPLNIVSDRDHLFIGCFWKALHKLSSVKLCMSTSYHPETDSFSEHSNKTVIQMLRYHLINSKNASTGFTPFQLNHGRSARVIPPITDAAVGTISTKFGLDATHAADLLNHMELDALEARNNLILAKSNQMLTANSSRSPEIVYSVGDQVLLSTFHCRFAPNQKAYKIWIPSRHKFMVSRDVIVYENVPTMPEDDDQNPALSEGVTASKSTQSNSPDKAVGREPSATSPPHPLTPQASASPAPAPIPTLPENQPSTASAPTPASTPAPAPMPTPAPTPLRCSECVTCPSWIKQAAEKQQAQEQVMKTHNKVIKEARTLWRQMKVQARTAPEPIPEDATVSTTPEGDIAQVAYMAAFGMNMPMNFCEVTKCSEADNWWTAMHEEIDMLQRHETGANSILAIHVDNTLSFSDSAEELASVQKQLHSIFEMKEEDPNWLMGFELIDNPQECTVSISHCQYISTILRHFKMEDCIPVPTPMESSLHLSVHDAPLTLEEIVEMKKQPYRKLVGTLTWISVISRPDVAFVSTHLAQFNTNPGKRHWEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H207</accession>
    <name>A0A401H207_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1302440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619342.1">
        <property type="nucleotide sequence ID" value="XM_027763541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H207"/>
    <dbReference type="FunCoup" id="A0A401H207">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H207"/>
    <dbReference type="GeneID" id="38785346"/>
    <dbReference type="InParanoid" id="A0A401H207"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="144"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="463"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="569"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1017" mass="110553" checksum="81157F13C0870969" modified="2019-05-08" version="1">MNLRRTNKSAKVPNVKLRPAAPAARRSKDVTPPPTWVHEPGSDADIDASFVDLCPRPFREVVLCATGISDKTSLFKQAIELGATCIPDLTDKVTHLLAEEPGSAKYRCALENKISIMRPSWITSCHEVWLRGDDFDLAESIEEHRLPLFEGVILSLSGIEEVDRRTEINRLLRGQGGVYVKNLERPVKVTHLLCSSKQEEVTEKMRYAEKFNQRGEANIHLVWEEWFWDSLEFCGRFDEQAYHVSKPPPKRRSLPEPATSPPASSSPAPEERQNPTDSGNLLADDGDEEIASVKRVPAVMLQIWESLLRPRGFEIMGDKLVRSPSKSQTAREKVDLGLDDWRPPSRQTSPTRSKAEHVSRIASQRPGAPGAPAVPTSALSSFRRANSFAPASRSMSAPRQPFQRVATLPGCSSFLGRRTASVHVGGDDAAAPVASTSSVNASSPRKGQMTSDGEPSASSSSSGSSNLFAGLKFRTLGEARCQNVRTALEEGGGSLVSDDAPDEEVDYIIVRLISGSSLYRAEGDERVRHKYRTECWLERCIFQERVCEPTEHVSFSPLKIRTPIDGAENINLSFSGLDQSEACWVRRLARALGVNIALNFSRRSTHLLCPSRTGAKVEKAREWGVPIVDMSWVTDVATTGAIPLVDRTPAVPEPEPEAAMEVDPSPADRKGKGREMAPERPMANITNGAPPIPCRSEDRIYHRDADASADNQAWAEQDPLDADIDTVLPEAPCIQEAGDGKSFGQPNALLGGKVEPGLSNVTPPRPRRPTTQPVSEHAPSPGRILVEATRDTLVTMVEQPEAAATPVKAVDSDPDRMELIPSSTSPSPLKMPSPLKRPDHELTESAPTSPRKLSRTSSKGLQDSISSLLGKRSSEEDASSGKAQPQRAGKRPRPPSRAKPPSRADPVPVQPEVSQAPGGMQARAAFGPYALGEEDVSLFVDGEPGAGVSLQVTYEDAGQRSERSRLLQLLTSEKQEVWEVDERERASGVAAAPSAGRGGKKGKTRGATRRSARVAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H256</accession>
    <name>A0A401H256_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1302880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619385.1">
        <property type="nucleotide sequence ID" value="XM_027763584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H256"/>
    <dbReference type="STRING" id="139825.A0A401H256"/>
    <dbReference type="GeneID" id="38785389"/>
    <dbReference type="InParanoid" id="A0A401H256"/>
    <dbReference type="OrthoDB" id="2683861at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="642"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="728" mass="79446" checksum="89CD0DEC41A8747B" modified="2019-05-08" version="1">MTQLKDWFQNHTRASTMRKGHSAVLSLKQKVKRKPENWQAYMLTYWDRLKDDWDATFSCDALDFPPNTIITNSMKFSHHCVYAKSRYEAMQDDPEVKKTIQEYHEEFDESNTHARLLQQNIDALRHTVEMTLDEIQRQMGMVGIFLVGGPEPRRGGDLRCDQMGTHTKTYKKNFMQHLSSFDEDVSKPFGQYLELSFPLQAHREVVLPTPITANASTPVVFISQDESATAMSNVNSDAGGLVSKSASSSTSMVVATATSTSSRMGNSASASVSVNPSVVSSISASASVSMLTSVSASDGQVTASATISSPAPSPHRSSPLPSLPATPILCNLSAEHGFELPMQQRRKGGLQKQQVKGLPASRRSSRLTSDIEPTSSEAKGLIGQPVDFIPAHDPAPIVDPVPVHFPAPVLDPVPAHVPVMHIDPVPAHDPAPVVDPVPAHVPAVHIDPVPTHVPAPVLDPVPAHVPAMRVDPVPAHLSAPVGLVLAHAPSVHVDSVSASVLAQVPALVVDPIPVFVVNPVPARAPAVLNDDMLPPWLQKALGHLRTLKGVSGWEDILVLLVMLEHRSGYPKKKARYSKDIYKYRPDALSAWMGYGRKFNSLPHGMGKASEMRVGFHEWWAALQPATRAASEWPFSQDRDALWGTWGTIAQAGDLGFFLIVMYLWWWASVLDNDNKQRQFSEALSDVRWMLEGIVQDLEAGASDITAGSISSKRKSETPPACAAKRAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3E3</accession>
    <name>A0A401H3E3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1403170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619822.1">
        <property type="nucleotide sequence ID" value="XM_027764021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3E3"/>
    <dbReference type="GeneID" id="38785826"/>
    <dbReference type="InParanoid" id="A0A401H3E3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="206" mass="23617" checksum="6D6980B920CEDA34" modified="2019-05-08" version="1">MSAQSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVRWEEGLRREMFAVRGICGDLALAGHADHIDHGGVIASVLTVCTFNREVLRPISIDVKAIPCPTTLVPRPKNLLEDSPDYWWKWDRQVGPAGSPMEAWWYKLGDPWEKVYTISESTLVQLEQLHVRVANLTSWLHERTDQNLDVVLEELQEATRQLRELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H412</accession>
    <name>A0A401H412_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1501610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620067.1">
        <property type="nucleotide sequence ID" value="XM_027764266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H412"/>
    <dbReference type="GeneID" id="38786071"/>
    <dbReference type="InParanoid" id="A0A401H412"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="187" mass="20112" checksum="9D125DBC18F4A9FA" modified="2019-05-08" version="1">MSAYDVPSSPAQSPSPTLSHDMSGFSFPLNGQPNSLPDTSAGSVAPHNTIVNKPSIEMLGRVSFFRHCYIQYKGTKQPSDDTAPTRPSGLHARRGTPPGSALPASPSRTSQSSTRSSEARAMHLLRTHIRPRSTPRRPPRAGLCCASSPSARRCRSCASERTPRAWAQVCGRLRRVSSACAALFDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4V9</accession>
    <name>A0A401H4V9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1601290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620380.1">
        <property type="nucleotide sequence ID" value="XM_027764579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4V9"/>
    <dbReference type="GeneID" id="38786384"/>
    <dbReference type="InParanoid" id="A0A401H4V9"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="5584" checksum="E8C4EF587DFBF55B" modified="2019-05-08" version="1">MQEQETRLENLAAGDILFTADEKTSINAIISGHEIKGNRCFGDPQAAHVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4W8</accession>
    <name>A0A401H4W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1601390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620390.1">
        <property type="nucleotide sequence ID" value="XM_027764589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4W8"/>
    <dbReference type="GeneID" id="38786394"/>
    <dbReference type="InParanoid" id="A0A401H4W8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12935" checksum="2571993B17128B2D" modified="2019-05-08" version="1">MVRPSVTHAVRPLYQDRRPVDFRESLASLLEIGSRYSQWLIGAELRRLFFLRRRCLPDEAKAMAEDKDEDVDEDGDVARDQHRGSPIRTIPLIEQYAMEEMPGCHPPKATTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5C0</accession>
    <name>A0A401H5C0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1602540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620504.1">
        <property type="nucleotide sequence ID" value="XM_027764703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5C0"/>
    <dbReference type="STRING" id="139825.A0A401H5C0"/>
    <dbReference type="GeneID" id="38786508"/>
    <dbReference type="InParanoid" id="A0A401H5C0"/>
    <dbReference type="OrthoDB" id="3268830at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="719" mass="79003" checksum="F94AD5C0353B31EC" modified="2019-05-08" version="1">MDEPLSSPERKSVKVTYSARRKRRNSVANYAEESSEEFKDDEDLKTEESGKVSVQKKGTTKTDGPKSTPKKADVMPPPASTKRPKDDATPAKKPVSKAKRKPDSSVSPVSNETKSTPNGKPVSAIGSRLTKFPQTPRAQSPDSMADDRSSIGESSKPSSRARKTEAERKEFLESDPYSGEVEPHRVFCTACKEWVQLNPKLRYIMRLWLVHRKECGKQLGNDEKNETELKSEVAPDEEDDNISVTPSEKSGTRRRGATATPSARVATAERKLKLVNDTQVKAFTPHTVECASCMATVTLDGEIEYDVTEWEKHKLICSGISPLVQTAEDALVPPASVTEGQDATRPPPSTASTDATMIEAEASPSRTGQKRSREDDSEDQRRDDGAELHTIWNDILPRTSAGPKPHRRGEAQVSERASGDSDPIIPSLTRAAPVWLWRSLFSLFPPSSTYTSPTRHMELGKLLLPDGGQYTAQRHGPPSEDTFRISELSGPATTVVGSPKMPTSQFSYGLTLLASLAEHHEGGTHNIVAADLDEPPAPESPRKKTCSLSDSSNASSSGRRPTSGEKRREKKLREDRMAIVLSPQMVQCQRCGAKIKLSLKSTYDPFHWQKHRERCLKRPDGVARSMKAATEQHKPAWPAESKIRTASNGRAPSSLTPPLTSDGLEDDERSSEDSAVKREFASPPTLPEPELALHKPDAAFEDYLLPQLDMGAAQRAHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5G9</accession>
    <name>A0A401H5G9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1602970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620546.1">
        <property type="nucleotide sequence ID" value="XM_027764745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5G9"/>
    <dbReference type="STRING" id="139825.A0A401H5G9"/>
    <dbReference type="GeneID" id="38786550"/>
    <dbReference type="InParanoid" id="A0A401H5G9"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018820866" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE89633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="640" mass="69486" checksum="0779BE046C52194B" modified="2019-05-08" version="1">MLETSWLALAVAAVLPLARCQNLTSSWPHDYPGIPDGDYSPEWQCYFEVAESLPNVTWQLPRSFAGNIGVQRAGHPNDTLFFWAFESEPGSLTATDSVQPWGIWLNGGPGASSLLGLLYENGPIHLNVDLGAYENPYAWNTLADYIWIDQPVGTGWATADAEGYAADEDQVASDFVGFLENLVKVFPSLATRPLYLTGESYAGTYIPYITKALFSTPNPPVKLAKIAIGDGTIGSGATSELLPTTYVIETYPQLIGYDPEVFQWFQEQQHLCGYDLNLTYPQDGYFPDLGYVYPVNGAINAETLNKRKPILTKRALLQEARVRYGNFGRIPAGRVGHLRRDQYKRDLTGRANGTIDPWYGCFTYDAMIDYALNFSYPWSLAGSENYNGFDVYSVRDALNPEVPMDGSTFFNDPGSVAALHAPTSKAWVGEAGYCFLGGEDCEDPSVEPMAFLNGLAANASDRGVAIVIYSGNDDTLVSHRGSQVVIQNTTFGGIQGFTREPSTPWYNEEGEFAGIVHQERNWTYILIKGAGHLVAGNQPEVALTVLREFILGNNSTGLVTEINGVATVISGEVSSLAEAVLPGQLGIYTGSGSTQGTYTYPSATIAAWSSYILTATASPSAAITSQPAERRALPGQNRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5T3</accession>
    <name>A0A401H5T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620633.1">
        <property type="nucleotide sequence ID" value="XM_027764832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5T3"/>
    <dbReference type="GeneID" id="38786637"/>
    <dbReference type="InParanoid" id="A0A401H5T3"/>
    <dbReference type="OrthoDB" id="2739946at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="172" mass="19121" checksum="1A9AE5E3CF23ADED" modified="2019-05-08" version="1">MGKISLKQITTRHQNSDGSTKSAPWKLGKGVRAGRRNPGRNDGYTWNGSNFVCGSDIDGGGYGIEEDYPHELECSSGDTHAVRYKDAEIQVPSLYDISLGDIAKPERKKKKVATGPAREFEMVDSVQRVIVLDDFELGYEERVEAIEDEWESIEREDKIRPLYSAILAGTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6Q8</accession>
    <name>A0A401H6Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1800850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620976.1">
        <property type="nucleotide sequence ID" value="XM_027765175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6Q8"/>
    <dbReference type="STRING" id="139825.A0A401H6Q8"/>
    <dbReference type="GeneID" id="38786980"/>
    <dbReference type="InParanoid" id="A0A401H6Q8"/>
    <dbReference type="OrthoDB" id="2691920at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="33346" checksum="0507B945F5DE7990" modified="2019-05-08" version="1">MLLGPPSGTGVAGPSGMHEVPAAVLGLSDMHMEANTPVAEEFTSPIDANVAEVQAIEALPIPPLLTSSGRPIRTNCNQLPARYRDVIPEGPTCMSQPEEMRELGEEPTSAPLGTPVSELYMPNLVRSLPNSFSLVHQYLHVPLRDPDDGVSVENLVIGQAPRDESDDYTIASLSPAPHLFGPYPNKSSYLLGWWYWNGSMTKSKSDFKDLLAVLSNPRFTVLDLVGTKWDIIDHQLGDSGPSTIFNARDGWRETLVVISIPSGQRGVPPADFKISGIFYCPLEEVTRAVFESTAAATFHFELYTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6V2</accession>
    <name>A0A401H6V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1801660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621055.1">
        <property type="nucleotide sequence ID" value="XM_027765254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6V2"/>
    <dbReference type="STRING" id="139825.A0A401H6V2"/>
    <dbReference type="GeneID" id="38787059"/>
    <dbReference type="InParanoid" id="A0A401H6V2"/>
    <dbReference type="OrthoDB" id="3251353at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="207" mass="23475" checksum="B5AF393B06AC6451" modified="2019-05-08" version="1">MSTTAYSDFFRRRTLGRASSPPTWACYEQIPYDDDYSDSGSEDNSCSEDEEDYSQPVHGGDSDREPPAVHESEKHAQHGDGDMEIDVDDEAVSAQKIADFKKDVKGKQRAIEPEHESPKKQHRKKHRQQVFTLRPILTIQRSQGFVWNQDLFVPPYIKDRYVASTSPPNASGFVSSSVSSTNSSMMDYEVEVVEIRVREGELKDIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4L1</accession>
    <name>A0A401G4L1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0100090</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3 12"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608050.1">
        <property type="nucleotide sequence ID" value="XM_027752249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4L1"/>
    <dbReference type="FunCoup" id="A0A401G4L1">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G4L1"/>
    <dbReference type="GeneID" id="38774054"/>
    <dbReference type="InParanoid" id="A0A401G4L1"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE77137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="389" mass="43558" checksum="64F54A478B07364D" modified="2019-05-08" version="1">MSFVKLSIFGTSFEVTTRYVDLQPVGMGAFGLVCSAKDQLTGSSVAIKKIMKPFSTPVLSKRTYRELKLLKHIQHENIISLSDVFISPLEDIYFVTDLLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLRICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVAVDIWSAGCIFAEMLEGKPLFPGKDHVHQFSIITELLGTPPEDVIRTIASENTLRFVQSLPKRERVPFSEKLHCSDPVAIDLLEKMLVFDPHKRINATDSLAHEYVAPYHDPTDEPEAAEKFDWSFNDAELPVDTWKVMMYSEILDFHQVGDAHLGDGVPEGALAAPEDPPRGTDARAAPAVVPAPAVVVAAAAGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Q8</accession>
    <name>A0A401G4Q8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0100380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608079.1">
        <property type="nucleotide sequence ID" value="XM_027752278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Q8"/>
    <dbReference type="STRING" id="139825.A0A401G4Q8"/>
    <dbReference type="GeneID" id="38774083"/>
    <dbReference type="InParanoid" id="A0A401G4Q8"/>
    <dbReference type="OrthoDB" id="3248529at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9939" checksum="E9B30CA30347A577" modified="2019-05-08" version="1">MILALPPGATAATFNISSAYRITPVHPSQQHALCIWWHGKVYIDRAVCFSLSSSAGVFGAVADMLVAIYCARGYGPLKKWVDDFFVVHLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G663</accession>
    <name>A0A401G663_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0105170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608550.1">
        <property type="nucleotide sequence ID" value="XM_027752749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G663"/>
    <dbReference type="GeneID" id="38774554"/>
    <dbReference type="InParanoid" id="A0A401G663"/>
    <dbReference type="OrthoDB" id="3256360at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="25"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="299" mass="33932" checksum="4CDBD635416AAFDB" modified="2019-05-08" version="1">MIHDTSQLEQDVVNLTTTGRIWYISMVLLLYDYCLTLCDEVHHVWRSRSLRGRLIFFTNRYWPIAFMVFDSVVLRVFQTSDTGVMVNCHFFFQWAVYSPIPSSISLGIILISKLHAMYGCNRTLLAVMCTLLVVEIVATAAAGGIAAYKMRAVTVAAHTGCFPGNDYAYDWSFWVPPLGFEAFLFALALWKVVQEVRDDMQTSRLMVVLLRDSIFYFGAACTILLINFFVWLFRPALLGAFVPLVTTCRSIIGCRMLLNIQEAAEMTADTPSDILPSIQFRTFTVNEEGNNKECSRDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6C8</accession>
    <name>A0A401G6C8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0105860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608617.1">
        <property type="nucleotide sequence ID" value="XM_027752816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6C8"/>
    <dbReference type="GeneID" id="38774621"/>
    <dbReference type="InParanoid" id="A0A401G6C8"/>
    <dbReference type="OrthoDB" id="2780168at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19982" checksum="ED8FFF8AC7DB0630" modified="2019-05-08" version="1">MLTFPHLRVLSLHHEVSSPEDVYGFIHRHSSLLEVNVSFSSFRHFLSLESLMLLVEGTGIWTHQFTLGDEHERDMSQGSSNIGFKSFAFTRMPLASDPTHSSQGPLYELTRLALPVKIQAAFWSSDEWVSDVPQFLATADVFRAVEELRLSYENIQLYKKFTDFMREIGERLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G724</accession>
    <name>A0A401G724_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF803-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0108350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608866.1">
        <property type="nucleotide sequence ID" value="XM_027753065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G724"/>
    <dbReference type="GeneID" id="38774870"/>
    <dbReference type="InParanoid" id="A0A401G724"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="442"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="69776" checksum="F380DA836BC3AD17" modified="2019-05-08" version="1">MNFMASVDSGDSQISIPVGITIGLLASFVQSLGLTIQRKSHVLNQSLPEDDRKVEHRRPLWLLGFGIFISSNLFGSVFQIASLPIVILAPLGAVSLLWNAFFARLLLGDVFSPWMFIGTFLIAGGAVLIAIFGIVPEPTHSLEDLLVLFSRPVFVAYFSLLGFAVFVCLVITHIVEYSYSRRVSLQDVSPPLSPLLVATTAPSILTTATTASVAGDHPTERTALLDGKRDSPRSKSSSPSTASSVHYFYFHEKLSRTPALLAASYASFSGIISGMCLIFAKSGIELLLLTISGDNQFWRWQAWVLILSLVSCALLQLWYMHKGLVLADPTLVCPLAFCFYNLSSILNSLVYFDQFSLLSTTHILLVSLGIFVLLAGVFVVSFPSTGSYGVDVGTWTEGEPVDEEDSIVEEPEDYEGEPLPLHRRSQTLPATIGEEITDEESALDLHTAQSPTPSLPTRPPLTSGSPLRTRTLHMRPQSDTVLAPTSPLRSRSYRATSPTPSGSRRRRRTTITGTVQSPPHPSTLSPSASGLPAFSIGLSPMSPGFSLVPKERRRRVLGRDSMVPSGADEGANTLGRRDSLFGAPWLRRTVSEGAVDRPVAAGADEERGEGGEGEALLGPASPRARVRWKWLRDAFTGRGLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7D8</accession>
    <name>A0A401G7D8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0109720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609003.1">
        <property type="nucleotide sequence ID" value="XM_027753202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7D8"/>
    <dbReference type="STRING" id="139825.A0A401G7D8"/>
    <dbReference type="GeneID" id="38775007"/>
    <dbReference type="InParanoid" id="A0A401G7D8"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="331" mass="36797" checksum="AC203A505CFC0160" modified="2019-05-08" version="1">MVQIALDRKHKASRRDDYVGPFQMGLIPPTPRDGGNVKKWSELSAGGKVARTTARTTNFAVILLGAGLSAVLIYALTSELFSKNSSTVLYGEACEMLKASPKLVAYLHKPYVFHNNPPTSVRPRHRNHRVSSQIVVDSSGKEHMLLHFYVQGQSPGSSQAAVEFQSDSDSYMDSAIGWAKGVASAMSEMTYDDLVETVSDRASRTLERAKRMFRFLSGDPVPKPLAPEPTKVAVKEEKKESQWTWTSGFTGLFAGLRTASKAADGRGNSPDGKLYTEGEVHADLVMNDDGYFEFRYLLVDIPNSYQRTPRRIFIERSKNVSENEPVMQWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7M8</accession>
    <name>A0A401G7M8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0110540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609084.1">
        <property type="nucleotide sequence ID" value="XM_027753283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7M8"/>
    <dbReference type="STRING" id="139825.A0A401G7M8"/>
    <dbReference type="GeneID" id="38775088"/>
    <dbReference type="InParanoid" id="A0A401G7M8"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="339" mass="37613" checksum="E9D4EDCF3C88493F" modified="2019-05-08" version="1">MPRPNFPGNFVLDLHDLAAIILSCHAQTEDRFANAQLVEINCGDTPLLTLPSHVLPLEWHYHVNASQKRVAYIVRTNSEAPERTTLDTFVALEGVRASGNCTLSRRELEDVFWRCKDFDSGYVLAYVAQSVIEALPASASIRARTSSGFELICSPSDVVIGEIRVRPHEACLMVDYEPRPDLGPSKVNMTQHLSGFDSGLSWIYLLLGKAVAADLEVDTRVVLDLVLPQIGGRGGGGELFALERGIDYHQKVLPKYASEFEGLKMSEKLMLSPPDIQRRGDALTNMVLAQLGKVIGGQDGFCRYCGEDGVETRCSKCKKAYFCKECQVLGWKYHKVWCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7X5</accession>
    <name>A0A401G7X5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0111260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609156.1">
        <property type="nucleotide sequence ID" value="XM_027753355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7X5"/>
    <dbReference type="GeneID" id="38775160"/>
    <dbReference type="InParanoid" id="A0A401G7X5"/>
    <dbReference type="OrthoDB" id="2960452at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="800" mass="87963" checksum="77FD60C4C402F69D" modified="2019-05-08" version="1">MTALATSPPLTRTVADVLRHHRQLGRDMQQYQHGTSPDPNARPHWERVRDRFPQHLDRGRPPPPAFSPMRRPRRPAVGTPIPRLADHKTCAPPAHAVSSPLWLRFRDRARLDHHADLPACQHQSRAELLAKHAHPLGPNTAPRPTQMRVPTARAIRRAFAAPLHSTSTADTLHHLHSRQCDHHADLPLERQYRAWPTAKHAAPLRAPPPRLSPSHFATARGLTNTRTSRCANPNAAPSPSHNTRTRSVRIFLCYFAYILLTSSNANMVPRPTKTRAWTARAIPHAFAPLSTAPRPPTPSTTYSRQPDHHADLPFECQYRAWATAKHAPPPRALQPRPSPSHFATTPRSTTARTSRSNAKAAPCLSQSTHLRCVHNFLHTLAPVSAPCPDSECRRTCPNSRTANNSHLARFPLATATMASVTDAPATTTGSKRKMRHLSPSAPVPSPAKRQKPEDSDDIFSPTAHTDSTASDTPTDDAHASHRPDETPGKPYRNKGKHVEKTRTPTEVLQSLSKLRETLAVTRAMNNVFVLMQPMYLKRAFPSNIAERLDHVSIATAHDIINLATADPTALHFVTIGASDYLQLKTSTHLTLFSVVGSVTHSDLISPSGRSRQLCVAPSALTWPRAAAVLGAILNRRTLVFPSFHAGLSFSTRLTTGTSNTPTKIRGMAPATPVNAQRGPPPVLPADRDVPTFDGCKPFKFSMRSISMLPKIHDDLSTESAVLLLFTLGKYIKSHPELDDENADTTISLNIQSIVLLANPGSMPRGFLEDEPMPLLGVFRPNSEPDQRHSDDSDDDDASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9F2</accession>
    <name>A0A401G9F2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0116880</name>
        <name evidence="2" type="ORF">SCP_0806440</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609708.1">
        <property type="nucleotide sequence ID" value="XM_027753907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9F2"/>
    <dbReference type="GeneID" id="38775712"/>
    <dbReference type="InParanoid" id="A0A401G9F2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="106" mass="11463" checksum="9658219E2AC308C5" modified="2019-05-08" version="1">MFERAFLLEGSRGPSHHRAGHRSATAARSHLLAVARASRGFAKPHPAWLHCCPTLVDARQPTAVKDGAAVVAPATEVQRWHEAPATCLSRLREPPAYLLELTANAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9W3</accession>
    <name>A0A401G9W3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0201730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609889.1">
        <property type="nucleotide sequence ID" value="XM_027754088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9W3"/>
    <dbReference type="GeneID" id="38775893"/>
    <dbReference type="InParanoid" id="A0A401G9W3"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="226" mass="24812" checksum="E95767D7AB3DD6EB" modified="2019-05-08" version="1">MASTAIPPLNKISLVGIWIESVLWGMKMLGVTSIVLFAFATAHIAGSLHQLLEAFIYVPSPAPPLYSTLYWANKTNGVAVMKTVLYDTTVWLQDIALVHSNMITCNKHVSRSLRIWRLYVVWDRNWLICILPVVVDLAHMGSACAATGLLAQPNADIYGVELKRLGPVSWSLDLAVNISVTAAIAGRLWYMGRKVSLAASSRGLNSDQNPYLAPIFHFRVPPIPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAG5</accession>
    <name>A0A401GAG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor tau subunit sfc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0203510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610067.1">
        <property type="nucleotide sequence ID" value="XM_027754266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAG5"/>
    <dbReference type="FunCoup" id="A0A401GAG5">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAG5"/>
    <dbReference type="GeneID" id="38776071"/>
    <dbReference type="InParanoid" id="A0A401GAG5"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="36"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="224"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="62834" checksum="BC2B30472DDEF086" modified="2019-05-08" version="1">MDTNGAGPSTLPNVPELSSSVPPPAPSHPLSSTHFYSIEYPGYVQPTSIPLAVERLGGQTSIETAFKRVSAKNESLLELHLRPGIPFAHPVPGDIVPTSNVLLKVIKRKRKRPNVEEVTGVREEEQVGEYTVEAVGVIPKTVRFRGMVDYQFQPDMNDPLAKLRVAMDNMDVESILKYKIPPEKEDYMISVGGDPSAMQIDPQLMDEPQEKQPDTKMKSNLRLFTPPLFSRQGIPQNYNYRANTASVVTTVVDEETGEEKKRLINRTRWKGYGPISILFSDKTVPDKPPATVEEKRKEADPKLLKKLEELFQERPIWTRAALFNQLAPWEMREVINSKFLLPLVSYVFQDGPWRDTQLCLGYDPRQDQDARFYQRLYFRNTSHPVVRPSITIKRQEGRVEAQARSTDTAIREVDRRSHIFDGLTVTKETAAFQLCDIYDPMLKEMIEDEDDVREVCNERDGWYSTRAIERIKTVLRHKFFSLLGGHVATREECEALLVPQEGTNKLPLRPTRRLKPGKHNMAKGALRPEDAAAQRLTAMIEQKAKDFQSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB29</accession>
    <name>A0A401GB29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ACBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0205570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610272.1">
        <property type="nucleotide sequence ID" value="XM_027754471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB29"/>
    <dbReference type="STRING" id="139825.A0A401GB29"/>
    <dbReference type="GeneID" id="38776276"/>
    <dbReference type="InParanoid" id="A0A401GB29"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022408">
        <property type="entry name" value="Acyl-CoA-binding_prot_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00880">
        <property type="entry name" value="ACB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="496" mass="55602" checksum="9CC09AC7885205E7" modified="2019-05-08" version="1">MDSRQLIDAQFDRAVEIVQSLPKNGPIQTGYEEKLTMYSLYKQATVGNVQTPRPSVWDMLGRAKWDEWAKHKDLDPYEAKWKYVEALLKVLRRYSDKTIAMDLVRELESYSGDPSNMVMSASFSKSTRSSSSGSTTSDDHPLYELGNIPAHIRNTQTNIQASLPPPGPQVDQSSSEDEEAGDQVPPVSSAYAQSQADRPQSSLSTHRYRTPARYRTPATRSLIHSPPIPISSVPATQPHSEYQAQSAFGEPVNAASTPPHPRIISTSSASDVVGPGHTFSARPSFRPPSQPYYPRPYSLQSGIPRPPSRQALERAIEGVQVHLAALTERIEVLENSIHRSTVSVVSARDSRSPRWRSADHRDLGGQSERIEWDLDDMGMWSIVIRPLTRVVALFKHLLAFIVQTQNNSPVLVIVRRLFLDISFMLCVLAVFKVAWRRSGMRRKEVVAALAGLWRAVVGHKQPRVMLMFCWKLLSSDLALLHRHCKRPVYTSNSAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB63</accession>
    <name>A0A401GB63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0206030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610318.1">
        <property type="nucleotide sequence ID" value="XM_027754517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB63"/>
    <dbReference type="STRING" id="139825.A0A401GB63"/>
    <dbReference type="GeneID" id="38776322"/>
    <dbReference type="InParanoid" id="A0A401GB63"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="187" mass="20700" checksum="EC307F7586029E10" modified="2019-05-08" version="1">MGLSMSSLWSSISSLVHWGKEQDVRILMLGLDSAGKTTILYRLQIGEVVSTIPTIGFNVETVQYKNVKFQVWDLGGQSSIRPYWRCYFPNTSAIVYVIDSSDVTRLPTARSELLTMLSEDELNGVPLLVFCNKQDVEGALKPEEISEQLGLAGGEKERPWSVRGSCALKGDGLEDGLDWLVSAIQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBM5</accession>
    <name>A0A401GBM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0207740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610487.1">
        <property type="nucleotide sequence ID" value="XM_027754686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBM5"/>
    <dbReference type="GeneID" id="38776491"/>
    <dbReference type="InParanoid" id="A0A401GBM5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="125" mass="14398" checksum="9EC08439AFC86853" modified="2019-05-08" version="1">MEYPHPLLARRQNQFPFDLALLVRTYPVGDLRYPNHLSRPHPLLRVTVIPTGMDVSPNKDHEPAGGHATDVEEIIMSATAPDDDEDHNISCGTRNVRRELMLQRSSLVAHLFFFFFLFPLRYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBM7</accession>
    <name>A0A401GBM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0207510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610464.1">
        <property type="nucleotide sequence ID" value="XM_027754663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBM7"/>
    <dbReference type="STRING" id="139825.A0A401GBM7"/>
    <dbReference type="GeneID" id="38776468"/>
    <dbReference type="InParanoid" id="A0A401GBM7"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="68"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="285"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE79551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="456" mass="51106" checksum="26909610C6F25A4F" modified="2019-05-08" version="1">MHLKLALNNGASSSLFSPSSSARMMLAGSSVRILPRRAGYAGAYSISTAVQFYQNRQLELYAAKEAQRLTLRQLVFFGRCMNDERLIKSANYVRTELSVRIAHRLRDMQSLPYVVVNQEGVTKVYELYWTAFDKFRRYPPINTLAENDAFCVFLRNLLDEHKTAIPNLSLGLSLSSPYLAPDRLDSFMRRMLSSRISRRVLAEHHIALSKSASLKRNGGPSSQDHVGIIYTGLGVKDSIDKCARILRKRPHNIDQDFVESVESDALWSDVIVDGHVDTTFPYIREHLEYIVFELLKNSFRATRIKHSNVHQLPPIRATVVAGKNDVCIRISDQGGGLLTPEIKSPSDLFSFSHIRNATRLEDARLGALRTVSSSRRGMTATVDEQISNWQQAKQNDESEEDIGDGPHPRLGIGLPMSNTFATYFGGSLELVSLDGYGTDVYLRLPKLGTNLEGIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBR5</accession>
    <name>A0A401GBR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="11">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0208180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="11"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610531.1">
        <property type="nucleotide sequence ID" value="XM_027754730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBR5"/>
    <dbReference type="FunCoup" id="A0A401GBR5">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBR5"/>
    <dbReference type="GeneID" id="38776535"/>
    <dbReference type="InParanoid" id="A0A401GBR5"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="187"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="597"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="985"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE79618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1015" mass="115268" checksum="D23920F3256B0D5A" modified="2019-05-08" version="1">MNDDSVAPKDRKSRRGLFYSPERSSDILTGTRSTTPSPDGSRSDLSAATDHGRHPIILGICAMDIKARSKAMREILTRLVERTRGAIEVKVFGDKVILDEEVENWPRCDVLISFFSTDFPLDKAISYGKLRNPYCINELHPQALLWDRRLVGTVLDHLKVPTPRRLEVSRDGGPKVEEELREIMKRRIGVDLGGFRVTPEVIMSKDGDAIIIDGEIMEKPYVEKPVSGEDHNVYIYFKGGGGRMLFRKVGNKSSELDPNLNFPRTDGSYIYEKFVDVDNSEDIKVYTVGKDYTHAETRKSPFVDGVVRRNTEGKEIRFITHLSEEEKMWAAQISEGFGQMVCGFDMLRCDNGSTSQVIDVNGWSFVKGNEAYYDKAAEILASICIQATASVERPLPAAEATIEESPTWLLKANVTVFRHADRTPKQKLKFNFPIGEVWTQPFVRLLNGEKEEIILRERAQLTRIATAVEEAKSLGADGENLAKLSQLNSALFSKIELPGTKAQLKPVYSKKQAGQVRKLTKLTLVFKWGGEFTHSARYQSRDLGETMRKDISIMNKDVLKNVKIYTSSERRVVASAEIFAGALFDVHRDSYPAALSIPPVSNGDASSLSSQDGYETNASNFSNGNNLHSSTPRREHSQPSGQRPIKLIVRKDLLDDSNAAKDLMDDVKKRLKILLRPGEPEKRPELTWPKSMKKEPVEVVKVRSDPYRTVRLADDCTLKEVIELLNTFRDIMRRNWVTLDVDKVQERWCCGDEPWLFRERWEKLFEDFCDVKQEKFDPSRVSELYDTIKYCALHHRTFLFSIFSENGMAGARPPQDRRLHELYGRAKALFDLVAPQEYGIEPEEKEEIGVLTSLPLLRNVVEDLENARNNEECSLTLYFTKESHIHTLVNLVLLSGLPIANRRIPELDYCSHITFELYERNHGRGKSDKEYSIRLSLSEGAHSSNVLDSALDARHSLNVQARKKLTQHLPYSLVIEKLSKHFDRIREDEDTDPDEPVELDALSAPVANDSSHDYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC82</accession>
    <name>A0A401GC82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0209340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610646.1">
        <property type="nucleotide sequence ID" value="XM_027754845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC82"/>
    <dbReference type="FunCoup" id="A0A401GC82">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC82"/>
    <dbReference type="GeneID" id="38776650"/>
    <dbReference type="InParanoid" id="A0A401GC82"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="474" mass="52215" checksum="DC86ABA313E32B43" modified="2019-05-08" version="1">MKMYQPSPEAALKLLNFVNSSPTPFHAVHSASLRLEKAGFRKIREKDDWEKELKAGGKYYFTRNQSALLAFTIPQRWTSGSGVSIVATHVDSPNLRVRPVSKKSEASYLQVGVELYGGGIWHSWLDRDLSLAGRIVLKDKSGGFTSKLIKIERPLLRIPTLAIHLDRTANDKFVFNHETEFVPIIGQIESQLNSAQESSESPKMQNKTRKSATDIQDDHDPTLLAVLAEELSVAPEEIHDFELHLYDTQPATFGGLRNEFIFSPRLDNQLCSFAAVEAIASYAGAESFSSLEDNVNCIALFNHEEIGSVSTSGAESSLVPSLLQRLSPTSAAYAQSVARSFLISADMSHAIHPNYTSKHEENHCPKMNGGVVIKTNAQQRYASDAIGSFIVKKLIERKSGNVQNYEVRNDMACGSTVGPMLSKIGVRTVDVGCAMLSMHSIREIAGSHDVQAAIDLFTSFFEGFAAVDRQLHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCU8</accession>
    <name>A0A401GCU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0211820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610893.1">
        <property type="nucleotide sequence ID" value="XM_027755092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCU8"/>
    <dbReference type="GeneID" id="38776897"/>
    <dbReference type="InParanoid" id="A0A401GCU8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="171" mass="19137" checksum="C202D444BDF99A25" modified="2019-05-08" version="1">MPLTDQIAGVLELMFCRKLHLATHAAHSAPSIKVPPSMPSAVLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNKVLEAELERKWPPPFGESEIRIDQPATLVDMHRRILAWILPRVLIPDRQTKMLQATRALHPAIAASKPSSTTASWRHNPLYFLPPEECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD04</accession>
    <name>A0A401GD04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0212440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610955.1">
        <property type="nucleotide sequence ID" value="XM_027755154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD04"/>
    <dbReference type="STRING" id="139825.A0A401GD04"/>
    <dbReference type="GeneID" id="38776959"/>
    <dbReference type="InParanoid" id="A0A401GD04"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="268" mass="30917" checksum="FB192FE0ADA82EBA" modified="2019-05-08" version="1">MNLLAGWLPSSQTVLDFLHAVFLGIIAHLYLDLLFKGYMFSGIGGDDSPKQKFEDTVNSVRWLSHVTRLPKNLGENQSLKKADEWHRLLTIMPILLWVCWKDEHDRISNVTPPIPPNAKTRPTHSRNCKSIYFAILLLCAGVRILASCKISMSQAQIGQDFLTQYNRKMQELGVDLTINNHLSTHFAKFIKLFGPVYGWWLFAFEQFNGMFERVNTNGHDGGCMELTLMWHWVQCHLIYEYLLALPPEAHSKEREYVERVIKSEGHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDK2</accession>
    <name>A0A401GDK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RSE1/DDB1/CPSF1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0214760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611172.1">
        <property type="nucleotide sequence ID" value="XM_027755371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDK2"/>
    <dbReference type="STRING" id="139825.A0A401GDK2"/>
    <dbReference type="GeneID" id="38777176"/>
    <dbReference type="InParanoid" id="A0A401GDK2"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="1">
        <location>
            <begin position="23"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="178" mass="20067" checksum="E7AB4BAB089102D9" modified="2019-05-08" version="1">MLYAGAHLTRRLDHHGWIRVCSQHIAVGTTVNRGEDLAIKGVVYIFEIVEVVPDLSSSHKRWYKLKLRCRDDAKGPVTALCGMDGYLVSSMGQKIFVRAFDLDERLVGVAFLDVGVYVTSLRTIKNLGLLLCALRLIFPAGFIVGREPTARHSLIFVRMMLTPRPSFLVQSQSQSHWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE81</accession>
    <name>A0A401GE81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0302010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611399.1">
        <property type="nucleotide sequence ID" value="XM_027755598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE81"/>
    <dbReference type="GeneID" id="38777403"/>
    <dbReference type="InParanoid" id="A0A401GE81"/>
    <dbReference type="OrthoDB" id="2910914at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="131" mass="14843" checksum="A337F340DD42C230" modified="2019-05-08" version="1">MGQTKKVEKYVMKLWSWSEICAAAPLQTFTLRTTEDLWDAYWRFGPSARIVYDADPLQHESAIRNALVQCQKLDILFPQGDLDDNDSVNNVLVAVGPAIVDGVIHRNFLSGKIATPYIMSMVHKEAQHLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEU1</accession>
    <name>A0A401GEU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0304330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611627.1">
        <property type="nucleotide sequence ID" value="XM_027755826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEU1"/>
    <dbReference type="STRING" id="139825.A0A401GEU1"/>
    <dbReference type="GeneID" id="38777631"/>
    <dbReference type="InParanoid" id="A0A401GEU1"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="6">
        <location>
            <begin position="142"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="382" mass="41491" checksum="4803D09A73E06BA1" modified="2019-05-08" version="1">MSQPHDKKAKKRKHALAEIGADEVPPTPAKKAKKDKDKHRAGAEHMHTHAHKGKGKARADVDGEFRVVQASLAVSVPPVFASNLARGVEELLDSMLMRYIPALHGVVLAHDSLRFLDRTATIKADCPFANCRVGFDATVWSPRVGMKLVGKVNLCSPDHVSLLIHRTFNASIPRHHISTDEWEFEYGPAENDPEFGPEVAAENDADGTPKMGADDEKAAGVDRGGRWVHKITGAKLGGEDGSLEFTVVGLTVANQMLSLVGSIQPDPFSPEHVPVHTAAASESREKAAPSNIADEPEPLAVDGDSPDIAMDGEDEEEEDTFEMLGRLADEAAAQEKEQRVKEEEAARKEKRRKRKEAKSVQGQDGAASDVPEVKKAKKKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF22</accession>
    <name>A0A401GF22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0304890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611683.1">
        <property type="nucleotide sequence ID" value="XM_027755882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF22"/>
    <dbReference type="GeneID" id="38777687"/>
    <dbReference type="InParanoid" id="A0A401GF22"/>
    <dbReference type="OrthoDB" id="3359595at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019218143" description="TM7S3/TM198-like domain-containing protein" evidence="6">
        <location>
            <begin position="25"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="89"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="338" mass="36478" checksum="141D2C9CA3FF162A" modified="2019-05-08" version="1">MATPARLLHILAWLFLTVVGDASASPVDLYSVETSGQSLSKRGPYISHANGTTSVIDPNSGSIIAQGSPSDGSGHDFSAPAIIWIVYSFAVGVPLALVGLRLLRFTSGTGLGVLLTVCIWVAFINTETASALPDLVITLAPVGGFLVAFSFGMHEFGRVAGIGFLSILGGFAFGVRICLFRDGLLAPEHYADWLIITGFGIIGLLIFVWKRRASVALSSSSVGTFLTALGIDLVVEKQSGMSWGLRFLFDRNHAHFEYLTYVGWRPTTVTIILLAVSLGLTPVLAFAQLWIFRRRPEHTSIPTVDNRLSTEYHSEDKTLEIPRVAIQYAPSQEPTEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF52</accession>
    <name>A0A401GF52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0304520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611646.1">
        <property type="nucleotide sequence ID" value="XM_027755845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF52"/>
    <dbReference type="FunCoup" id="A0A401GF52">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GF52"/>
    <dbReference type="GeneID" id="38777650"/>
    <dbReference type="InParanoid" id="A0A401GF52"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="755"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="841"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="997" mass="109413" checksum="A17BF0E5ED1DFF43" modified="2019-05-08" version="1">MSARGLSPPPLYDSPSHATTTLKPYLELPHLLSLTWLAYPILSLLFVVFRLQLSVASAQGSVAGAKQDLLSSCNAAQHAATAAASMPRYLAVAVNHQITNAVNDMLDAARDTMILALTIMEAIINFIVDTYRSTFLCFLELVVRGGLSILIGFVQEANSFLSSTLGSIRTSIQNDVSSANSAIASAVNEINKINPFGNISVPQFSIPSLTSLENVTLPSDFESALISLNNSLPTLSTLKSDLDSILDTPFELVVKEINETFANMTFTVNALPIPQQNTLTFCDNLDTSVVDDLARDIVKVAKIGTVILLVLAVLLLASNCLLEWYKWRLLKKHLQRTRDAWTSDPSVYNITVAKTSVPTVDMSDHNLMVLQADALHPHLMKIANMLARLFRMSPSQYIHLRWFFHYVFHPPALACFLIGFFGLLSVQIQIIAIRPLADKYSQQAAASVSGYTDLIATSINSSMYNQSSVYADQVNAQVDIVQSTVNDGLFGWVNSTTTTLNDTINAFYNDLQDAVSTVFNGTILESPVSEFIKCFIGGKVSDIEIALTFLHNNLNINIPRVNESALVLSSAQVNEMTAPIATAAVGGGSNNSTGILGTLIADYIEGLKKERIMFSIFMGLWGIVVLMALAIIFWHAYGRDWLEAHRRRKWQRRQRAGINGLVIPFRNTSTSTPVPPLKDEDGGEMVEVNLPSFTPMPSPHPRSGIFDGIRTSMRRHSGTPSQGHLLQPPSHPLSMRKPQFEKSWDSFLDHSAAAASAQRHSSSPSISHPTKLMSLGSRGRERFTGDEKQADVEGGASDKHTTSWFPRLWNVMRKNDRAEEQMDETSSPRARARPQLTIRVDAPSTESDDLTVVDGADVDDTPRSAWSVSPVLSPPKLPWMHKQTPARKSDLPSSHTSKPLRTDVPVSVDSVYGPPEPQFPVAVPLHHGFEPDPSMPHIRVLVPPSLHPTIIAHSSQAVDPFVTPFDDEHQVPDVQVSSDPFSVRRSIPTNPFIAMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFH4</accession>
    <name>A0A401GFH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0306420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611833.1">
        <property type="nucleotide sequence ID" value="XM_027756032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFH4"/>
    <dbReference type="GeneID" id="38777837"/>
    <dbReference type="InParanoid" id="A0A401GFH4"/>
    <dbReference type="OrthoDB" id="4505683at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019017610" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="205" mass="19139" checksum="FEB13C4456E01820" modified="2019-05-08" version="1">MFKVVSILLAAAFLGGVSAQSSSAVPTGLPSSITPCILSCVQQAAASGGCSSFSDLSCVCTSTAFQSAALSCLQANCTSAEVSAAQALQSAECVAVSASSSVASATSVPSSLSSAASSAASSVSSAISSLSSALSSSHSSISSALSASHSSISSALSSATHSSSSSSSSSTSSSAAMALDLISAGGLASVGVALAGVVFGAGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFJ1</accession>
    <name>A0A401GFJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ribosomal RNA small subunit methyltransferase NEP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0306510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611842.1">
        <property type="nucleotide sequence ID" value="XM_027756041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFJ1"/>
    <dbReference type="STRING" id="139825.A0A401GFJ1"/>
    <dbReference type="GeneID" id="38777846"/>
    <dbReference type="InParanoid" id="A0A401GFJ1"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="353" mass="39151" checksum="9D9B8E4592F8A566" modified="2019-05-08" version="1">MVFSPMIISPRPRRLSESGSTHTLRTMHPQSPRVPASNTRIRPNSVSGVTRTRTSPVDPSRPIFQMHSRDNSDWYLFHDEDMSEESSAPPSPPLPELTYQPAPAVTIVHAHDSQPCDLPVPLQDAGKMPDISNRRLIVVLERASLEPCWVDTTGHHTARTQTASKCTLLNCDEHQKLLMRMGREISEARPDITHQCLLTLLDSPLNKAGLLQIYIHTSQRILIEVHPDVRIPRTFKRFSGLIVQLLQRGAILGASDSKVLLRIINGPLDAHLPHDAIKIALTGNAAPRRLQPYLRSLAPSRPIAIFVGAMARGPDNFAEHIVDGRLSISEHALSASVVCGKFCCALEDLWDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFN5</accession>
    <name>A0A401GFN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mating-type switching protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0307050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611895.1">
        <property type="nucleotide sequence ID" value="XM_027756094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFN5"/>
    <dbReference type="FunCoup" id="A0A401GFN5">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFN5"/>
    <dbReference type="GeneID" id="38777899"/>
    <dbReference type="InParanoid" id="A0A401GFN5"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="8">
        <location>
            <begin position="27"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="293" mass="32883" checksum="50473269F760A66F" modified="2019-05-08" version="1">MSRLDTGTQPSAAAPNPPVVQPGFGQNIIISPRQRSNPILECIRHIGKEFGEIPADYQVGRTTGVLFLSLRYHRLHPEYIYTRIEGLGHFYNLRILLILCDVSEHQEPIRELTKTCLINNITVLVAWNAEEAGYYLSTFKQFEHKPPDLIKERVDKDYHSMLRTTLTSISKVNKTDVETLRTSLGSVADIARATSEQLQNLPGFGQVKAKRVKDAFEKPFRNSAMTTLPSQFQQYSRAGGLDESNPQQSTTRGSASQSELSTSTRKPREPSPVWDIELDLNDSTPTPETADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFP0</accession>
    <name>A0A401GFP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0307210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611911.1">
        <property type="nucleotide sequence ID" value="XM_027756110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFP0"/>
    <dbReference type="STRING" id="139825.A0A401GFP0"/>
    <dbReference type="GeneID" id="38777915"/>
    <dbReference type="InParanoid" id="A0A401GFP0"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36816" checksum="F392FF506BCE8378" modified="2019-05-08" version="1">MAVLEALFLLGVLALSIAISLIVTVPLTGALVRLRANYNPRGLQLDPEGNVEPHTGPVVTSFFGMLKRVKRIEGWSGLYKGMMPTLLASAVLTAFAVIALNSTSASYHGRVNPPSAGPFGVLAYGLFSMLISLPATIITYRSITTPYKLPYFRPIYSLRILLTPTERRKPWILYLTPGLLLSQILHVVYTAFILRALRSFLVPLPSPGDASDVHFSSIKFGIYVGIEIWSTAVLCPLEVLATKLAIQRNHAAPEYNSVEQEVEEDAVMTEEYTEYSGVEEDVIGLRHEKDPYLGLVDCAKRVVDEEGWKALYRAWWLTMLGGVLSAFASAAPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFS5</accession>
    <name>A0A401GFS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0306760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611866.1">
        <property type="nucleotide sequence ID" value="XM_027756065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFS5"/>
    <dbReference type="GeneID" id="38777870"/>
    <dbReference type="InParanoid" id="A0A401GFS5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30402" checksum="1CDF8A342CDDC708" modified="2019-05-08" version="1">MSSKHAWKVNSYLYIEAIIDNEEEEEEEEKKEEEKEELAELLADIQHAQQAQACLDDACVGDDAADAKAMAQSITERDLAARRAQQASQSGGAVISLALDGIHLQATENGFLSPWGKKFKGGLLQLELTLDQVTFDVHMTQNDVFVFNAAKFMPKTVIAKLILFCVDFELAAGMHMIVIQGEQCDLISVIHSVISEQATIINFYHKKLDDELSSLVLPVTQLHPLWAAGDVVKVKMGLHAGLEGQVIAVDNFDVTIVHVNKVEHVHSTYDDASKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFV9</accession>
    <name>A0A401GFV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0307840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611973.1">
        <property type="nucleotide sequence ID" value="XM_027756172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFV9"/>
    <dbReference type="GeneID" id="38777977"/>
    <dbReference type="InParanoid" id="A0A401GFV9"/>
    <dbReference type="OrthoDB" id="2502792at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="280" mass="30185" checksum="A085A3378EBA770C" modified="2019-05-08" version="1">MVVVPPLDAPLPHLFDPILDYLSSSLPPPVYNTLVTVASQSVALVTSLFTLTMALFPSSSSTWDAQTILPPLITLLAAYLALVSFYRTTWWMIRTGFWFIKWGTILAVLTAGAGWVMSNANANGGSGVGVPFAGGFIPVIGGFLLDMLNGQGQNAAGGARSNPRPKTQSQSTRSRSRPQNQPKSPRPKAWESWDRHREWQYNENEGTDAGSEGEVKKVIGDIIGAAGRVLSDGRWWEAAKGAVDEFAQVLGESGGTDDGRGEEYKKQSTRTNTKAKAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGK0</accession>
    <name>A0A401GGK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612223.1">
        <property type="nucleotide sequence ID" value="XM_027756422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGK0"/>
    <dbReference type="GeneID" id="38778227"/>
    <dbReference type="InParanoid" id="A0A401GGK0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="221" mass="24233" checksum="804B71CD59C42A0A" modified="2019-05-08" version="1">MDASIILRKYILTEALLHIEIFTEPFDPILWKAWAVRMHVLLVFMVQAQSEAASVGIILPLLHDIPVLAQVEIHLATAHTMEGSRRMIPRIADHLPAVIPHGLTARILYDDPTVREDFGLGHPPDGLPDIGTLHLQVETLHDAACGLYYVMLRIIGRCELADGTLRGLQIGMDTGHTSDTTLATRNTDPCAGKGLDPRAYTGGLSKSPRVSLPRAAPRVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGN4</accession>
    <name>A0A401GGN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0310560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612242.1">
        <property type="nucleotide sequence ID" value="XM_027756441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGN4"/>
    <dbReference type="FunCoup" id="A0A401GGN4">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGN4"/>
    <dbReference type="GeneID" id="38778246"/>
    <dbReference type="InParanoid" id="A0A401GGN4"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="551" mass="60211" checksum="BFD9701662122A02" modified="2019-05-08" version="1">MSSSIELINPKAESIRRAAALQVNTTGAMGLANVVKGNLGPRGTLKMLVDGSGQIKMTKDGKVLLSEMQIQNPTAAMIARTAVAQDDQVGDGTTSVVLLVGELLKQADRYISEGVHPTVIAEGFDLAKKESLAFLEKFKQPMKLDRATLINVAYTSLATKVHLSLAKQLAAEVVDAVLTIRPPPPSEGSGEFREPIDLHMVEIMKMQHRTASETQLVRGLVLDHGARHPDMPKRVENAFILTLNVSLEYEKTEVNSGFYYSSAEQREKLVESERRFTDMKCRKIVELKNLVCDKAVDAKEKPKNFVIINQKGIDPMSLDILARNGILALRRAKRRNMERLQLVCGGVAQNSVEDLTPDVLGWAGLVYEHTLGEEKYTFVEDVKDPKSVTLLIKGPNPHTIQQTQDALRDGLRAVKNAIEDEALVPGAGAFEVACAAHLMGPVKKSAKGRIKMGVQAFAEALLIIPKTLAANGGYDVQDVVVALQEEQAEGNTVGIDLQSGEPFDPTVEGIWDNYRVKRQMLHSCSVIAVNLLSTDEILRAGRSSLKPEGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH72</accession>
    <name>A0A401GH72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612388.1">
        <property type="nucleotide sequence ID" value="XM_027756587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH72"/>
    <dbReference type="STRING" id="139825.A0A401GH72"/>
    <dbReference type="GeneID" id="38778392"/>
    <dbReference type="InParanoid" id="A0A401GH72"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019185368" evidence="1">
        <location>
            <begin position="22"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="247" mass="26395" checksum="334AD047179CADA0" modified="2019-05-08" version="1">MRSTIAVSALLVAASAAPSLALPIAPASGSEALNWYKLGNAASTVGKTLLHLREEDALVARADAGSEAINWSSFHPTPFGPAVVREDALIARAAPAGSEAINWKKLGGFASTVGKTLLSLREDPIVARAFEDELLARADAGSEAINWGAAYLFHPLREVDPILARALEDELLARAGGSEAINWHDVGQGPIHDVREEELLARTETEGSEAINWHSVGHNLKEFGQGLIHDAREDELIARGFVWSELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHG4</accession>
    <name>A0A401GHG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0400070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612549.1">
        <property type="nucleotide sequence ID" value="XM_027756748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHG4"/>
    <dbReference type="GeneID" id="38778553"/>
    <dbReference type="InParanoid" id="A0A401GHG4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="15104" checksum="C3E4498DE5228B30" modified="2019-05-08" version="1">MPDVPTPLPHLVSQPCDRPTDRPSPALRRRPSEPRSAAVARSVCAPIKNIFVCLRCTFTAISFPLSATRSLDVRSPELVDFHPADGGGGDSVAVHPNFLLSVSFTAPALPRRSTSAPVFSPQFTAVHVLLLGAGTLRLTAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIK6</accession>
    <name>A0A401GIK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0403640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612901.1">
        <property type="nucleotide sequence ID" value="XM_027757100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIK6"/>
    <dbReference type="STRING" id="139825.A0A401GIK6"/>
    <dbReference type="GeneID" id="38778905"/>
    <dbReference type="InParanoid" id="A0A401GIK6"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="754"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="973"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1077"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="973"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1106" mass="120085" checksum="153FAE7BF7E5615A" modified="2019-05-08" version="1">MRSQLLARRTRSLVKTQPPYHRALISSTHALRYPRKEHPTWSPQATPRLSKRASSSVTPSAVGTDPPAPPLPNPSEPPSEPPSDDVEEKSKRRTSVLTSSKDADASPQLPDGLDILWTPESDPAHPSPSTGSTKALPPPEIFDELLHHLHITFHPQTQHRAVYSSPVGPLVEPTFALYCPIEGGDYYIDQTVRELAGQTGAEVLVLDAVQLAAGESGHFGKAASVLQIPNNPLHFPSSSTSSPASNARAMPIPEDDEFDDPTQFIPTQHMTLHVLAPITSRSRALLASPARSNPMSKLKAFFDDLVNLSSESRTLDVSPDFSPPSPPPRRPRIVYVRDFPTLAPSSSTWYPALLSAVRQRRQGPISRPNSPVVNPMTIIFGITPPFIAPSSPSTSSGPNQGLVNLLNSRSAASSGRLTNQNGKSDYGEDSSGDKGREKRMLKRLKRWARGDVTSQDLPQLSVSSEEADELSGSKPRSTNIVVVGGPEGLSGFPSMLGSALPGSTSSSFGRSSHAYSETDGKTQFFRTSIVMPALRSLSHEKTARMARRREINESTMRMGVAAIGGELTKWERDTDVALSSEQTSMSENEQAMWEEWGKTIQVWSVVRQIADRAVGSVIAQGARELLKSSLEATSIPWSAVCDGWASQRSMQDIWKSMLQDTSVKILHESEANADKKEVDDEPSVDEVVERVKQDPDLDQHEHRLLSCIVDTTSLSTTFSQVHLPPHTIDSVRTVVSLPLLYPVAFQHGILKEHSMAGCLLFGPPGTGKTLVVRALAKEAGCRMLAISPSDVMDMYVGEGEKLVRSVFSLARRLSPCVVFIDELDALFGARVSRETGGGIAHRGVITEFMQEMDGLKSSKEDNVIVIGATNRPFDLDDAVLRRLPRRLLIDLPGEKEREEILKILLRDETLSPGVNLKDLAKKTQSFSGSDLKHLCVSAALDAVKEHVDVPWRAPTSGSTNPVTLTGSAASVVSDATPSQASQAASLEPADALEASADQTNATSGSGPAAETALPSHSRTLSSRNFDKALQEITPSASESLGSLAELRKWNDEFGEGRRERAKQFWGKGRFGFVIETNENNKVGSSENEHEKMEAQPSVSHDSHPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIR1</accession>
    <name>A0A401GIR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0404450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612980.1">
        <property type="nucleotide sequence ID" value="XM_027757179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIR1"/>
    <dbReference type="STRING" id="139825.A0A401GIR1"/>
    <dbReference type="GeneID" id="38778984"/>
    <dbReference type="InParanoid" id="A0A401GIR1"/>
    <dbReference type="OrthoDB" id="2749714at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="438" mass="49607" checksum="2CFEDB32A1E2003A" modified="2019-05-08" version="1">MGKQFDGFEPNLNFRRFHSGSRLQVTHHLLSLQRHSEITCRTKSLDNVIHNPFPGVFGDIVPCTYHRHLMADLAPPKGGLPPPPASLHSSNQPGTPDSQLGKMTESIDKGAIWVAHIKTLSEAIIAHSEYLDSWRHHRKYTHLTMLWRFSDISDEDKTCVTMQVNHFAKQSEEKKTQLSAALSHLTELDYWPLFPSKMKTTATELKSNITELYTALQKLQASSLTVQQVTQSQLKSPEVLIKQLQSLETSLAGLKNRMDDQFLTLKVRELEQKLEVTGKKVEEIRREVAEVIAGWSVMAAENAELRHGNVQLKNEIAVLVRQQQKHQEAITASRQEIISLHEAVKAALMQPHGLSSTILVPPFELDTASLVEAVKPVILQSLHEDIWLLLEDAKNNMQNLLQEQNSQMYVTVLSKMATTVKIVEFLATWMDHLPRQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIY7</accession>
    <name>A0A401GIY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0405500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613083.1">
        <property type="nucleotide sequence ID" value="XM_027757282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIY7"/>
    <dbReference type="FunCoup" id="A0A401GIY7">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIY7"/>
    <dbReference type="GeneID" id="38779087"/>
    <dbReference type="InParanoid" id="A0A401GIY7"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="347"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="404" mass="45474" checksum="AFE607EEC95A2D5F" modified="2019-05-08" version="1">MSFRPARKRAGSSGEGSSAPKISKKTRFVEPSEDPVNFAEEVDAQLENPSAQRKGRVKTEGYESDSSDDGEGVVRSRRAGVDTAAEGEDEDMFAVGEKEEKKVEESGKKKEEYLRLGDIEGQEFGGEMSGSEKSESVDEPEDEDDAERRKKAEMGFELSSFNMREEMEEGKFAADGTYVKSFDPHAVHDRWMEGLDEKEIKQARRNRRHREKEQREKMKAEEEELRQLGGKDVIEKDLVGMLKKGETVLEALQRLGAQAKKSGRSKQSMKPNNRRKAELNGDAMQVDKDVPKETSQIDFITHLASTLMSLGETDIYSKTYEELVRSVRSSGKVDQSWTPPSADVKYEYKWDVPGVSGQRGQVFGPFSEEEMQAWYKALYFGAAGEKVQVRSVGGDWGSWREVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIZ7</accession>
    <name>A0A401GIZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0405220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613055.1">
        <property type="nucleotide sequence ID" value="XM_027757254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIZ7"/>
    <dbReference type="FunCoup" id="A0A401GIZ7">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIZ7"/>
    <dbReference type="GeneID" id="38779059"/>
    <dbReference type="InParanoid" id="A0A401GIZ7"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="215" mass="23767" checksum="12489497E4CB730F" modified="2019-05-08" version="1">MLAARVYIVRHGETDENRLGIMQGQLDTNLNAIGIEQAQLTADALEMVPFTKAFSSDLKRAVKTAEMILKRHPHVELEQDPELRERNLGDWQGRKSTERGFRAPANAEPVGEFTGRAVRWWKERIIPCTTAWDGHGEPAHILVVSHGGLIGRLIVGLLESGRVEWATGSVLTTKCFNASISVLELQAHGGGEMVSYSDTTHLNVDFVESNADVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJA4</accession>
    <name>A0A401GJA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AC transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0406300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613159.1">
        <property type="nucleotide sequence ID" value="XM_027757358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJA4"/>
    <dbReference type="STRING" id="139825.A0A401GJA4"/>
    <dbReference type="GeneID" id="38779163"/>
    <dbReference type="InParanoid" id="A0A401GJA4"/>
    <dbReference type="OrthoDB" id="2677917at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="74602" checksum="1D84A0353901E65B" modified="2019-05-08" version="1">MGKKALPDAASSHSSLKLHVSRKAAKVMQTLKAGMKALTRPLKCLRKAASSSKLSCTSSRVSTYTSKPDTISIHSDSGSAEALALTDAISIHSSTSSSNEGGLEENDAQELTHLQATWRSPVYTFFKSNVSVEYYNGCKCHFFPCAARKCKNPLGGVRRYQDSKDKAFTLNLKTHAINCFGAAAVEAAIKGDKAPRDGSIFAVFAHTWKLVKWVTESNHPVRIVSDREFQELMMAGHPTLVLPSSMTLARDIKSLFEHCRERIGQLLREHPGHLNFATDAWTSPNHCAFVAWTVHLEFQGYPLSFLLDVIEVLESHTGQTLAREFQAMLVRYGIEQKILTFNGNNATSNDKQTTELAKLPNSFEEVHRVRCFNHTLQLSAKSLLKPFNAALAKLSDLQDDTPDDLPDLLGPDDDGDDDDDDDVENAGMEFTDEEEIYKEVDGLAELDDDAREALLNETADVQATLTKIHQLAFAIIHSSTIALPAWCEMCQHYKLRVRIIPRDVVTRWSSTYDMLSFAIRYRQPINAITADKVLKLRKYELDMDDWQIAQALMQVLKKYKKATLFFSQDSISTIANVIPTTSFAGEQSVPPAIQSVMGLARTTMNRYYSKTDLSSIYRIAMVLHPSLKLEYFKQRSWDQTWIDTAENITREEYIAVYEEAATLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJC1</accession>
    <name>A0A401GJC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0406500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613179.1">
        <property type="nucleotide sequence ID" value="XM_027757378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJC1"/>
    <dbReference type="GeneID" id="38779183"/>
    <dbReference type="InParanoid" id="A0A401GJC1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25467" checksum="1B7BFA0D4D84AC33" modified="2019-05-08" version="1">MSIPASPMLVNGVPSRAQTPFIRTSSPSPSIELSHASDEQEFATRLVSAIRVPVDFTDILVALRNRPQDRQAVVSMQRALEMVEWMQTARQELIAAEERTSRARTRVDQVWSLMRSTVTRTAQEIWREHGDEDIGHILGYTTNGIPASTPRSSPEPIPVRPRPPRSHVPSGRSPLSQPSFSTASTSSRRSHPYRDGRIPEQGSRTSRRTCYRCGGDHYVRDCPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJG6</accession>
    <name>A0A401GJG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0406880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613217.1">
        <property type="nucleotide sequence ID" value="XM_027757416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJG6"/>
    <dbReference type="FunCoup" id="A0A401GJG6">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJG6"/>
    <dbReference type="GeneID" id="38779221"/>
    <dbReference type="InParanoid" id="A0A401GJG6"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="35"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="480" mass="54250" checksum="0F7E336788F4A72C" modified="2019-05-08" version="1">MDNASSSLGMNDERRWRCLLSWLKNQHGMDVVDALLVECRDTKDAGKGLFATRACPPSTVLFTVPAKAMININTLSAIFSPRVREMTAVQQISLYLLLHRPAQDEDSLDLVYGPYISTLPRDFSSHPVTWFMKRHTSNEHDTESQLLKSLPPSVLAALENLSARFLKDWEVVNKCMNEEPDIMTMSSRSDFNKSGCAGDFNSVVDDFLWAWLNVNTRCIYYRVTPSQSDPDNLTLCPILDFANHSETPHIVPVNDLDLPGTKASNKLTRNLTFVCSSDIVEGQQLFLRYGGHPNRTLFVNYGFLDNFPPNAGAIGEFSADIDLQDVMEKLFSESRFQSWIRQELEDEGYWGDWSLHSSPQPAHPSYRMITALRLYHVVESLGPQVPPDSASDVILRSWKDTINGRTSSVSEDNERLWRNTLLDICELVAARARDGMRITLSGSGTSGWYSWMEENVRCLWREELEVATAVACSLRAGEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLA8</accession>
    <name>A0A401GLA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0413270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613853.1">
        <property type="nucleotide sequence ID" value="XM_027758052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLA8"/>
    <dbReference type="GeneID" id="38779857"/>
    <dbReference type="InParanoid" id="A0A401GLA8"/>
    <dbReference type="OrthoDB" id="2749836at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="301"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="767" mass="87396" checksum="EC16A3A7CB144571" modified="2019-05-08" version="1">MGCTFVTVPVKTFLSEFVPQPDVQAAASASQAYLHAFDGMPNSFVSQEHFFGRLARCADDCGLWRGYSRELVLSEDLTAGTPVGDPYKVNTHMALFRNEDAHTKESELHWSYEVLSIIYKPDATVDDLFAEEKDPNLPDAEMCATTRAHIQSIASTILSRQHRTSVFTVLFFPTCARLMRWDRHGAIVTEQFPIKVTQDLATFFWRFARLSPEQQGYDPTAKLVLPGSDDHRLMVDISQSMYRQNACARAMFAESLEDPDRPCWKLRVVPEGRVPMARRRRTKRPTCGKRWKAVPQEEKDEENEEAYARYFLVGKPHFEHTDLPGRGTRGYVALDCKTKKLVFLKDSWRFDPPVHQTEGAALKTLKKAKVTNIPTLVCYGDIGDQRTRTLEFVGPENSWPADRERDVSPTLVHSRLVVEEVCLGVHDFHDGKELLQIFTDVIDAHRQAVENAGLMHCDISSGNILIYERLERRGKELETRRSGLLCDWELAAPVRDAENGGKEAPRKPGSMGTWQFMSVLSLDHPRTAIATQDELEAFFHVLLQTALVYIANNFEVPAFIQDFFFTMDPPANSACPFNSCNSLKRKAMHTGVIEHEKRTLEFYDRNGGFHPFGKVFDLLILLFRAHYTTLIYEEDCEQQDMPPQTPLAVPRQGAVHRVGVKLEELNEEDLDARKHLAELLKTHQGMRQLLLTFLDREWPSEDKIEPELPNAESEVDSSEPPSSKEVERKLQLLGALSMKRGREEEDESSDMEEEPPRKVQRANSEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLG8</accession>
    <name>A0A401GLG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-specific glutamate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0500590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613929.1">
        <property type="nucleotide sequence ID" value="XM_027758128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLG8"/>
    <dbReference type="FunCoup" id="A0A401GLG8">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLG8"/>
    <dbReference type="GeneID" id="38779933"/>
    <dbReference type="InParanoid" id="A0A401GLG8"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028971">
        <property type="entry name" value="NAD-GDH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05088">
        <property type="entry name" value="Bac_GDH_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="637"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="917" mass="103305" checksum="EB9D9FF722431C0E" modified="2019-05-08" version="1">MTVLEPKSEPELTAAPTPLVIEDSYIAKHRELYHTGSLDPNLIDENDNGVTSIYTSSPSKTVTESPGTSCENRIDALYLDNSTPSKAYRLETYRLQGLVSATASQQLCCYFITKCNFPTSPPSLMYTDGKMDICTISDPVFLEKASENTLEIYQNVMWNVEMRYGPVIEVIEVEGSCERRLVIGYKMGSTSKFFSALSNLYHFYALYSTRKYVEQFSNGITIISLYLNPLPSVLNAPPIEHSIFQVMKEASLLYCLPDNPFFSAEPARTAGMPCRRRLMLVHHFCVSLLGDIIISESHRVWDTDCGWVFAQHFCNHLGPAYLALKNILDESNPSHAEVLNNIKHRFREETFMRESIAQVIHAHADLINLLPMLSYQHLQTQVPLSDEDLYDKIRKTVHNKHELQVLESFLIFNKHVLKTNFYQPTKVALSFHLTPDFLPEVEYPKKPFGMFFIIGGEFHGFHIRFRDVAWGGIRIVMSRNSENYSINQRMLFNENYDLASTQSLKNKDIPEGGAKGTILPLYISSSFLPFHTCRSGTDSRLSCFADWVQAQDCASRNTWTPGIKERLINLYGKPELLFFGPDGACPSPPSDHFILTMAMIEGTADMMDWAALHTRARGAETWWKSFTMGKSTETLGGIPHDQFGMMSLSIQQYVLEIYKQLGLREKDITKVQTGGPDGDLGSNEILLSSDKTIALHVPVTHFDKSKLSKDRYLVHVEDQDLKLPSGEVILDGTDFRNGAHLRFKAGLFVPCSGRPEAVNILNVAALVDSEGKPHFKYIIKGANLFLTQQARLYLEKQKVVLFKDSSTNKVGSSTLYAHHQSPHVAPSGGVTSSSLEVLAGLMLSTQEYVDLMIFKNRKPFQARVTENAVAEFQCLWREHVHAQGVKACTFISDELSIMLNDLQTELEGSDLYEDPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLY3</accession>
    <name>A0A401GLY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0502540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614120.1">
        <property type="nucleotide sequence ID" value="XM_027758319.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLY3"/>
    <dbReference type="GeneID" id="38780124"/>
    <dbReference type="InParanoid" id="A0A401GLY3"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="680"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1498"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1098"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1631"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1098"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1772" mass="197563" checksum="866F775804E5B17C" modified="2019-05-08" version="1">MPQTLEAEAFLSRIAVLPSGPGAAGKLSDVLQPSLDDEAALRKLFAMDKANARLDNLYVGLVDVFDAPDVIRTTRARVVKDEIDLSAKYVMPLSEGRRRKEGAPAMVATLEDFKKNWAIFSEGSLSQLLDWNNVIAAGGAVQACLNPVPEYAKVSKRALRKHFHTNEYPTSDVDLFLYGMTLEQAEVKINAIYEAVRDSVPWDVTCVRTKHTVSIHSQYPYRAIQIVLRLYRSPAEILAGFDIDAPCCAYDGKRVWANPRAIVAMMRQCNTVDTTRRSPSYEVRLAKYSERAFEVYVPTLRREEIDPTIFERSILRIQGLARLLVLEKLKDTETRTRYLTERRNLRGRQSVEQDRRRKYRKRYKGDLKTNVEFSGLEMNDYDVVSLHIPYGPGWDARRIEKLIYQTDLGMNSPFNPKNKDRRLHRHPAFFGTMEECLNDCCEHCIEPKNEEEKTQQEDENKAYIRGRVEFIQQDPGRQSISGSFNPIDVGEWAEQAYVGPVEKFFNAIAKLDRPAVAHLLQQEETDVNRRDHVGRTALQLAIVCKASDIACDLVDAGARITARVADGRTSLHLAAQLDLPAVVRKLLERSVVNAEKAKEDAEEKQKKKGRSKDEMDVDDGSGGDDESGSDDENSKNDWSSEDGAKGQKIEEQPQVDNGQIPEDETEEPDVFDLNAADWDMAFTPLQYAIASGSVSIVDELIAAGADVKVVTTANRYDAPRLHQLTATILTEDQDVACQIAKKLFAAGAVSSEADDELVTVFHRVVAAGRPQLVATFLSSDPNAKVVINTPHVAPFGTITSPIISTITRGNWSTLAILLAFNAKLTLTEEDFYRAREMSNKNSRGHVSNTYEGRVLMPIETALAKCDDVVDLVVALGADVNAPTMEAVKRNYTNKYHHNILDWVRCAISALDARLQWADAPDNDDDDLHAFATNSGWKGSRAQFFRNRREGELQYHLSLLTQQEKQILLEAKGYFSAVETLLSSHGAKTWDDLHPDDKADSEAKDYLIRHRPTERKSMKLLGYLRVVGECYNTSPVLPHLVARYDELFEARGRSEETPLQIVVWFGDSFDTPLSIALERGHWDTARLVLAIAHAQHQPDESKAQKFQTRDIVLDNDDEDSEDDDEDMDSDDEAIDFIDVAKRPSTVQTPTTARCLLQDMSVHWFSADGEQEQVGSVLKRAIVNDDFEAFAQIVDMHNGFPVPVPLTSSVLGDIIVSDRPDMLDELLRRTGLGVNIEVSVSEDGQAETVQKKVSKVYLGLNVHGKKRKDLATKGDPNAPPATETPTIPILWMAARAGALNIIKYLAGDRPVSAYRYYASTHSDERAQHLRQVRDLAGVLPRWLGWTMNAMNESVLTAAVIGDRLKVIETLVSLQPEQMRSALPARIRYVDFNLILVAANWGCSPEVFDYLLEQGVPVDVVDHRGWNVLHLLCSQDTVAHFKLLDHVLHKLPHDVAECLLVQQSKGVKNTPLHLAVKLRRLDHVGLLLSVKASPLVLRDDGGSTVLHVAVKQSSPKITRILLEAGPPEALFTEDSVGCTPLETACQIVLQHKVANGFIGNVYSPATLSEDFGSTIDRKPNSKLLPYTQDDKVSHLRATVQQLLQEGRLRNGTKLATELISFADNMEARLVERKPEAQVGESAKADQEPAEASQLKTDSVSPTKTLECLIEAAARADSRQRRLVHLLDVHQSVKSSLGRSVRPSECQKQIEVAVDDGLAQAVEESTEDLFERNSALSIWSSSAGRLRSSTDLFRDLPAGFPALFNVAMTCPHPMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM87</accession>
    <name>A0A401GM87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0503660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614231.1">
        <property type="nucleotide sequence ID" value="XM_027758430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM87"/>
    <dbReference type="STRING" id="139825.A0A401GM87"/>
    <dbReference type="GeneID" id="38780235"/>
    <dbReference type="InParanoid" id="A0A401GM87"/>
    <dbReference type="OrthoDB" id="3051522at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="136" mass="15196" checksum="5C5DD0E348690EF7" modified="2019-05-08" version="1">MGLCNRGAQHHAGRPVPAASIARGYGYPESRRLKQSIYNYLWETTLTDCFRRFSLFPVQIARFWVLRTHAFSAAVALASVITHGGLTKTVQVALGELKASVRPIRKSCAARRTLAVPEMYVKQPPAECHQPQHSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMA3</accession>
    <name>A0A401GMA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0503950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614260.1">
        <property type="nucleotide sequence ID" value="XM_027758459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMA3"/>
    <dbReference type="STRING" id="139825.A0A401GMA3"/>
    <dbReference type="GeneID" id="38780264"/>
    <dbReference type="InParanoid" id="A0A401GMA3"/>
    <dbReference type="OrthoDB" id="2742110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28111" checksum="CDBF4E7DB313E369" modified="2019-05-08" version="1">MDFEKWQLSCSGGTTNSNNWCSDLRRCLELPSLEWFSFHLRREWGPVTLGAIPKLRRLSIGAYQYYSTIGHLLTILGPQLDHIDLDISGSGLAQDEIEQLVMVIQRHASRVRTLAIQSYHIPSTPFIDDLVAHLPCLLHLHCGYGSYSNAIFDRLPRGLRTLQLEGTYRHPFPVQDAIKVLDRVRQGQSELDALSVVVQSDHAELADLASACTRSEVRFRVLKLEKVDILSMGVTHDTCAPFEPSRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMB0</accession>
    <name>A0A401GMB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0503700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614235.1">
        <property type="nucleotide sequence ID" value="XM_027758434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMB0"/>
    <dbReference type="STRING" id="139825.A0A401GMB0"/>
    <dbReference type="GeneID" id="38780239"/>
    <dbReference type="InParanoid" id="A0A401GMB0"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="40"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="309" mass="33001" checksum="BE964AFBC6ADC9B4" modified="2019-05-08" version="1">MTSSQQFTRQTVKVPSAEADVNLEVWLYLPAQHGDGPFPVVVAGHGLSLVKEAGFAAFGESWASAGWASLVLDCRGFGGSGGQRNFCCIARQVEDYRSVIAWAKTGEMQSLFQKDRIVVMGSAMSGLCVAELALNALEEGIAGAMAHCPILDGYGTAMALPPNFKLLFMVFLDYIGGKLGFSPLYVNVVAKPGEPAICNTPSCLPGFVSMYEQSDTPFSERANIVPGRLMVEIMSSRLDLSGIKCPMLVVMPENDDLIAPSVSREAIAKARGKIQSVVVPGGHFDVMKGGVGFEGNIKAQLEFLRSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMF7</accession>
    <name>A0A401GMF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0504510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614316.1">
        <property type="nucleotide sequence ID" value="XM_027758515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMF7"/>
    <dbReference type="FunCoup" id="A0A401GMF7">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMF7"/>
    <dbReference type="GeneID" id="38780320"/>
    <dbReference type="InParanoid" id="A0A401GMF7"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="98"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="33983" checksum="01937957543AB05E" modified="2019-05-08" version="1">MDLTTSLQKLASYRPQQTKKSRETFEKGVVLLRTDAFAKQGEAGWDALERLTLAAFDQTELKVADQCLQRISNKFPQSPRVDLLQGIRMEVTEPPEVALKYYDELLQEDSTRAAIWRRKAYVLRRMGKIDRAVEELSAMLDTFYTDVEGWLELADTYASCQQYTYALQSLSHALLLSPQNPFCFLQFAETAYLAGDITLSLKMFLVAVDMTDDEEGVPQDSIPVSLTLRAWYGVKLCTHRLITEPRHSSSSASQTPAPTTAKLANLDELSTERLRTAYLNVKGASPPNDHTSFMSTLATVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMK9</accession>
    <name>A0A401GMK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0504970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614361.1">
        <property type="nucleotide sequence ID" value="XM_027758560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMK9"/>
    <dbReference type="STRING" id="139825.A0A401GMK9"/>
    <dbReference type="GeneID" id="38780365"/>
    <dbReference type="InParanoid" id="A0A401GMK9"/>
    <dbReference type="OrthoDB" id="2799175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57952" checksum="A5262E3C062F6D60" modified="2019-05-08" version="1">MTHNATTGIHDLPDDVLLLIFKAVYSMSRKYPGRDNRSVSIFEADKNDVIWQDEDVSSPSNLFPDSLVPMCRLWKDTLSSVSAFWTRLVIFVDERPTPLSAITSRLALAAERALEIKLTRRHGSWPDADLSEQARVNAVISFLSAHMSRWKTLRLDVLHSSSVPRPHVAMHGDAANLVDLRLHSRLKDAPLLAYCSSLVIQATDDSNRMPTTHILETDIEIGPPLTVTTNQRHINQQLRAPRMSELQLDGVIFFASYSCAPVTWMSVRKLTVTHCVSPPSGMFTANMLLTCLNTMPSLRELTLVEVALEFYEEAMPALVHCGLQRCTFVDIPEQMLAALVGLLQNSELTSLTVKRCSMRRWAPGQWPLSSLTLEGINKSDDVLEALRAWPPRVLTVENCAGFDKVILAALADPYIFTCPGMQVLELSDCQGISSRELRMMIEGRQGGIGDDDAVDLDVGFISTLRVTGCGELDPNDKVFFQEHAFLRQVEWDGQMISEDFESDVDSVGWARADDFSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GML3</accession>
    <name>A0A401GML3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0505020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614366.1">
        <property type="nucleotide sequence ID" value="XM_027758565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GML3"/>
    <dbReference type="GeneID" id="38780370"/>
    <dbReference type="InParanoid" id="A0A401GML3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="108" mass="11860" checksum="465DE433073B4B0C" modified="2019-05-08" version="1">MQAPIRNAGTPQDPDRSASQPPTSDSTFDAKFKVPLTSTAMFKRSYSSQLPPHTAAILANILPMKVVFFWPSDATPLIQPMLQWCPLHSSTSSLDTMESHVVEVASSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMT2</accession>
    <name>A0A401GMT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0506060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614464.1">
        <property type="nucleotide sequence ID" value="XM_027758663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMT2"/>
    <dbReference type="FunCoup" id="A0A401GMT2">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMT2"/>
    <dbReference type="GeneID" id="38780468"/>
    <dbReference type="InParanoid" id="A0A401GMT2"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03053">
        <property type="entry name" value="GST_N_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="92"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="215" mass="23703" checksum="85FEDEDADBADE20D" modified="2019-05-08" version="1">MVLKLHGFTLSTCTRRVAMVLKEKNVPYELVPVDLSKGEHKAAAYTAVQPFGQVPYIVEDDGFTLYESRAIARYVAVKYAAQGEKVLPPLTDVHAFAKFEQAASIELTNFDPFASGIAAERVFKPRRGGVTDEKLVAGYVASLKLKLDAYDVILSKSKYLAGDELTLADLFHIPYGATLKLAGVDVLEDPSRPNVVRWWKEISSRPSWLAVKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN57</accession>
    <name>A0A401GN57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614545.1">
        <property type="nucleotide sequence ID" value="XM_027758744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN57"/>
    <dbReference type="GeneID" id="38780549"/>
    <dbReference type="InParanoid" id="A0A401GN57"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="208" mass="23379" checksum="1709A52C698DAD0E" modified="2019-05-08" version="1">MSAISAYDIERCLAASRGSSEFNATGMTKERNLQSGDMGVLHDLLRLPEDGEGSASREANHDRRVAPAMALFNYQVRDWQDMWDQYIDESKCDTSTPAPEDTTYLVVHREPVRPEFRPHEGFFIGASSDLAFEVLCSYMDSDDFIRADVLTDEAEPPWETESDQITSSQGQTSARGERVSRIAKMKARQVISDYCAETKRTRSGKGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNG7</accession>
    <name>A0A401GNG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0507980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614655.1">
        <property type="nucleotide sequence ID" value="XM_027758854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNG7"/>
    <dbReference type="GeneID" id="38780659"/>
    <dbReference type="InParanoid" id="A0A401GNG7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="131" mass="14197" checksum="B82158CCE07EB50B" modified="2019-05-08" version="1">MRINDACHVAAWHASRARPLCAIVPTFSDADRLFSSSSSSFLSSHPILTNDSTMALDASDICKAVQGTKMATVMAICIAIYELTGLGYPQGTETRDNPYPQVRVAYPRGYEYGYTSGYPGVYPCSALDEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNT1</accession>
    <name>A0A401GNT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0509440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614800.1">
        <property type="nucleotide sequence ID" value="XM_027758999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNT1"/>
    <dbReference type="FunCoup" id="A0A401GNT1">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNT1"/>
    <dbReference type="GeneID" id="38780804"/>
    <dbReference type="InParanoid" id="A0A401GNT1"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="27591" checksum="BA5D948B17546CD6" modified="2019-05-08" version="1">MKLNIANSATGQQKTIDFDDERKFRIFYDKKMSQEVPGDPLGDEFKGYIFRITGGNDKQGFPMKQGVLLPHRVRLLLSDGHSCYRPRRTGERKRKSVRGCIVGPDIAVLSLVIVKQGDNELPGLTDNVLPKRLGPKRATKIRKFFNLSKEDDVRKYVVRREVTSAKKENAKPYTKAPKIQRLVTPLRLQRRRHLRSLKRRRIERQKEQKGEYDTLIQKRVAEKKEKMAAAKASHKKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP29</accession>
    <name>A0A401GP29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar-sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614833.1">
        <property type="nucleotide sequence ID" value="XM_027759032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP29"/>
    <dbReference type="FunCoup" id="A0A401GP29">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GP29"/>
    <dbReference type="GeneID" id="38780837"/>
    <dbReference type="InParanoid" id="A0A401GP29"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="251" mass="27689" checksum="F6C42E2C33464B2E" modified="2019-05-08" version="1">MHRLGGAGIAAFERQQQSQRSFAELSNAISQAQVDLLHAQLAQFRSALAHYAASHRDSIRRDPSFRHAFQRMCTTIGVDPLAGPRRGGWWAEMLGLGDWQYELGVQIVDICVSTRERNGGLIEMGELVRLVSKLRGVAGGVITEDDVIRSIKTLKPLGAGYEVLDVGDGKKMVRSVVKELDADQAVVLAIAQEEGGRVSEGMLITRRGWTYDRASAALQNMLLRDGLCWLDEQDEAGGVAYWIPSAMHWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ38</accession>
    <name>A0A401GQ38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0603150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615250.1">
        <property type="nucleotide sequence ID" value="XM_027759449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ38"/>
    <dbReference type="STRING" id="139825.A0A401GQ38"/>
    <dbReference type="GeneID" id="38781254"/>
    <dbReference type="InParanoid" id="A0A401GQ38"/>
    <dbReference type="OrthoDB" id="2717295at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="149" mass="16786" checksum="61F1872B0470EF47" modified="2019-05-08" version="1">MEYHSARNHYVDRIRTAKRDHWEAWLESADSDSVWTINKFTQAGPTDGGRTWIPPLMPTNGVGELISDNQGKSEILYDTFFPPPGITATPPTNVTYPPPAFLFTPPTDAQIEAVVKRLKDFRAPGPDKTPNEVYKRCIDILLPYLGPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQE2</accession>
    <name>A0A401GQE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615282.1">
        <property type="nucleotide sequence ID" value="XM_027759481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQE2"/>
    <dbReference type="STRING" id="139825.A0A401GQE2"/>
    <dbReference type="GeneID" id="38781286"/>
    <dbReference type="InParanoid" id="A0A401GQE2"/>
    <dbReference type="OrthoDB" id="2803872at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="561" mass="60959" checksum="8E7889B5F17DD172" modified="2019-05-08" version="1">MMAPPTWANTTELEWLQEQLPRFLDHQKCKKLQTFYRTLFTEWDTQFQECAHLFPAINPMVQLTPEQDAELTQAIAKQQKQLYNWYNNRKSKGCSADKTAASILKNFIPKGAVLVKHLPQVVEAYSHKYYKEKIKKDIDSEIKEKNLKKGEALPIVRCLTQAAYDAETPEVKAEIIADVERKKAEREAEEVQTEEAHLQGEYSPAEYQKMLDCMPAAFDQFLGAMSKSTGWRFSVFGGGPSPEDGGNLRSMVFHSGDSSSALKFSDTIPDFEMQFMEPFGQFMAMSYPLADHQRHALSSSLTPGSSEPPPEVITLNLEDLRYTMEDSPDAEDPITRGQASSGPSPSQDQGTPVSDTASADVSNAHMPVTTVGPPPSSEDGRPPTTVNDALQSSLAPSPSIPGPASPVPASSHSQNHLSASADAALPWAPNLAAWQFDIPAPAFDLDTDLQPISLDNAMLGIELDWMVPISPVTGALNFQPLMHVDAPSGPGSSQLNVADPGVSSSNTDPTCSPMSALRSPSYPQLLPEAPSSPLVQSTPSSTLPSGCLISRSWICSILVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQK4</accession>
    <name>A0A401GQK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0604710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615405.1">
        <property type="nucleotide sequence ID" value="XM_027759604.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQK4"/>
    <dbReference type="GeneID" id="38781409"/>
    <dbReference type="InParanoid" id="A0A401GQK4"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171:SF3">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="976"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1417" mass="155456" checksum="895C88B08FE2FD2A" modified="2019-05-08" version="1">MASPCTRDPRRPSRLPSFKRSFDEVGSDSDNSDNLLSSGSVAVRQAVHAVEDHADRNKRARSDTPLSDPGDIDEALFSSDTSSSTFNGSPNSIGSNAASEALPSGSATEQLPSPTQFEARTGFTPDSPPAPNPSEQYRISMERFDAFESNISVLRHSHSPEHRSLPVSHLTQVPSWSASSGTSVPPPHPFTHATIGLHAIPVTEELMLLGEDSISPTSSARSVHQVSRDRRSPLVATSSRAAYSPSASISASSSEDMRNWLDENEDHLPPQIDVMLATPTMPTFGEPVNSASDSLLAEGSRSLRFTDLGERMDLSPVLPRASRGRTPSVASQPAVRRTFMRETSSSGSSSRESDIRTSRPDTREARDSDDGMWDVRLHWTSDGNAAPYSSDGSRSVATHTRPYRTSGTSNHQLHSRREVPFRDRRTTLPRDFTGEASPTEAVFSRGFSGWDRLVSEDPYREFYEDIDETRAVAPTPRSSLLARAYSNSGSESDDVELLRRHIRGSEDSDGSLTGGLVYPPLRTEVSNVTSNSPEAFPPRRTSRGDDSVRTSNETTRHWFHPTHENQSHTADTSSNPFAAHLQGRRPSSRLYSTRPTPSNTLMSENAFEHRRALAREAVFSHRPGYASPTTTGAADRQRVPSVITSAGDVVQFDEWSDSPHPHRAHGTSDRSGAHSRSRSTSSPSRPWGSELYPPSSPHSPMVIDDNTFLETGGPPVESPDLPPEPANDTQPRTLNSRTYAFPSLVDWAVDDTDTTPVTGRPRPLWYDASTGFFYPTFTDQLPVSSTSFSSSNAEASHSSSRPTSRTPVPSEVSSLEIGGQRRANAIADLPSARVELDRVILTRTTPVSPPTLANIRPTFASDSHSHSAREPGVGLRPHTPPFRTNSRFPSHVVLPINLSPSSLASSHTERGLTSIAFGRPYNDIDINAYHDGPFRDTVARSMEIGRRRSTAMRRAEGTASRRPNHPSLPPLRIGQSPLNPSSAPSRLRLPPISHVSESTSFEERAETSRDTHVQAVDTPINPAYSDPSVYPGSLGFTANFDSRANSTEDFLQMPQYRAPDEEDAQAPYNDLRRIIARSTRTAASRVADGSSNTPGGEQVPALRADGSNIARQHQLIDQYRQDRSTQRQRTSGLWGDIDGVDGPRGPTFGSSEALEAWRHHSGNRSGYLQPRAHNPSGDPDASRTRSLQHSRASSTGGTELAERAVRTSRMRVARQRNAEMFEHHQHGFATHFGLLPRLPAMGFRGRNFGDFVRDDELDASYEGLLSLAEFLGEAKPRGTPADVVASLPSGVYRDWASPGNTEERCPICLDDYQPTDPVLKLSACSHWFHKGCIEQWLKGAGTCPVCRGRVENSRPRPEWYSASAQPNPPSTSRPSPSGSGQVGRADGNGALEDWDIELHDPDMIIRDHLRRRWRRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQM2</accession>
    <name>A0A401GQM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0604380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615372.1">
        <property type="nucleotide sequence ID" value="XM_027759571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQM2"/>
    <dbReference type="GeneID" id="38781376"/>
    <dbReference type="InParanoid" id="A0A401GQM2"/>
    <dbReference type="OrthoDB" id="3226546at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13560">
        <property type="entry name" value="HTH_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="72" mass="7527" checksum="5FABB4AE2A21382F" modified="2019-05-08" version="1">MAPNPQCTALAAAKDRKGLSYEQIASQLGTSEQHVVDICTGSKHPTTTEFDALARVLGITAPPPSDGAHVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQZ4</accession>
    <name>A0A401GQZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615584.1">
        <property type="nucleotide sequence ID" value="XM_027759783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQZ4"/>
    <dbReference type="GeneID" id="38781588"/>
    <dbReference type="InParanoid" id="A0A401GQZ4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="95" mass="10509" checksum="10B9125FD0356BB1" modified="2019-05-08" version="1">MNAIISPTWQSALYDPLVEGLQTVVSSYSDRTHLIFEAHTNMPLYSPSHLLRSTPRNTTPNPASQCSQSPSLKQKAHEEADPLSSSDGEHMETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR41</accession>
    <name>A0A401GR41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0606760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615610.1">
        <property type="nucleotide sequence ID" value="XM_027759809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR41"/>
    <dbReference type="GeneID" id="38781614"/>
    <dbReference type="InParanoid" id="A0A401GR41"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="55" mass="6040" checksum="C418AA3D1FDC48B6" modified="2019-05-08" version="1">MRVTHPTTIHRRCLCSPELSSHKRIATSGIAVAHNVQLKHTLTAPKTPGVQVEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRV0</accession>
    <name>A0A401GRV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0701270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615858.1">
        <property type="nucleotide sequence ID" value="XM_027760057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRV0"/>
    <dbReference type="GeneID" id="38781862"/>
    <dbReference type="InParanoid" id="A0A401GRV0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="113" mass="12754" checksum="453C29B882C3505A" modified="2019-05-08" version="1">MFPLSNIVYLCCTLTEGLALVTSSFLIAYTPQEAWPHFRNHECTLCSWFKVVAVVQRCAKSIYVLYWLPLHSVRLGALSAHSDLLVSSVHDSLYLHMIEAAAVVLHFYLVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS31</accession>
    <name>A0A401GS31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0702370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615964.1">
        <property type="nucleotide sequence ID" value="XM_027760163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS31"/>
    <dbReference type="GeneID" id="38781968"/>
    <dbReference type="InParanoid" id="A0A401GS31"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="176" mass="19061" checksum="32B7CB2046F39B6F" modified="2019-05-08" version="1">MDPFNNDGIDRRPASEVRSPFTLIPPAVAPDDDGMDRHPAADIAQLGPPPGGSTSMRVASRKYGCLRSPSTRRPGGPSSSGERGVRLILCGPSLRGNSAHPRDILEWDEQLHSLIPCSSYEQHSRPGLCPPPIAKATFVVVERTSRSRLYATGQQPIVAGLHPRFEQRGSFSSAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS62</accession>
    <name>A0A401GS62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0701840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615912.1">
        <property type="nucleotide sequence ID" value="XM_027760111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS62"/>
    <dbReference type="FunCoup" id="A0A401GS62">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS62"/>
    <dbReference type="GeneID" id="38781916"/>
    <dbReference type="InParanoid" id="A0A401GS62"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE84999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="388" mass="41891" checksum="E23ECB42BE8E36BC" modified="2019-05-08" version="1">MSLKMPQANGLQLFKEGYKHLQGLEDAVLRNIQAVAELSDLVRTSFGPNGRNKLLVNHLGRLFVTSDAATIIREIEVVHPAAKLLVMASQAQEAEMGDGTNMVLILAGEFLKKAEHLLVMGLHPSEIIKGYELASVKALAELENLSTSSLPSPLTQASLAAALKPAIGSKQYGSEDILAALVAEAALAVMPPNPKNFNVDNVRVVKIMGGSLQGSRVVRGMVFGREPEGMIKKVQKAKVAVFTCGLDVAQTETKGTVLIHNADEMLNFTRGEEQHLEKIFQEIADSGVRVIIAGSTVGELTMHYLNRLNIAVLKVLSKFDLRRLCRVVNATPLARMGAPTAEEAGYVDVFETTEIGGDRVTVLRQLGSGGDGRHHARDRARHQRLTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSY7</accession>
    <name>A0A401GSY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4203 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616192.1">
        <property type="nucleotide sequence ID" value="XM_027760391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSY7"/>
    <dbReference type="GeneID" id="38782196"/>
    <dbReference type="InParanoid" id="A0A401GSY7"/>
    <dbReference type="OrthoDB" id="3364886at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38466" checksum="78A5C9AF63496FED" modified="2019-05-08" version="1">MPVNDTDYTLSSLFSSYRYTLAYALPLLLLSIVLTFAGAFFTVDRSHTFAPQNDVVRSPSSTNSMLKKLGIRLRNIFLLEGGIGGLASGYVFGGMHLSVTVTVDESSIGAVHLSTFLALIVPSKTNQAPLSAASFLPVWIISALVCTLLAGRWKYAALAAAGIAGYILEFNASTLTSILTLVGAVMCLMPLQKYQHAFLRVATSPVGAFGMTLSIVLFACISLERLWISYGDGWNMSQEKGLSAAYCIFLLMGAACDWFLHNKLGENPDQKWDTYLTECAATLPNEAGHAGTFTPLTSFWSHHFGYKDLDPIAKDIVFTTDAELRFSIPLPHLLQKRSSSFTPSSPTEGFESPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTJ0</accession>
    <name>A0A401GTJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiol-specific monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0800430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616439.1">
        <property type="nucleotide sequence ID" value="XM_027760638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTJ0"/>
    <dbReference type="FunCoup" id="A0A401GTJ0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTJ0"/>
    <dbReference type="GeneID" id="38782443"/>
    <dbReference type="InParanoid" id="A0A401GTJ0"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019438541" description="Thiol-specific monooxygenase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="65195" checksum="85B3089DA8BD7FCC" modified="2019-05-08" version="1">MLFTLSSLVLASFVAAPCLASSQAAFSIPGADDSDNYEFKWPVQNVAIIGAGVSGLMAYRELTRAGLQAHIFERDRVPGGNWYYSEETPLDAPIPSADIAVGDFVPSLPPAGVELPYTEEYKDNYADVKRGHRGPKPLWDSLHSNAPAPIQQITDFPWPVDINWELSHYQLGKYLRSFASFLGLNSNDENPDTSYNTRVERVDKYLDENGNEHGWKLLLKKLVQTDYGTLKATWYTQVFDAVVVATGRYNAPHIPPIAGLPEVAQVFPDRLTHSRQYRHPEPYASETILIVGASVSGAEISRNLNPFAKKIYQSIRPDKSDAEHIPVSALLGRLPSNTTIVPEIKRFLPPTGSDFSAVQIELVNGTILTGIDRVIFATGFRYSFPFLPQYHNSSIGLNDTVPTGELQPIVTDGTHIRSLHLDIFYIDDPTLCFIDMNVGMQSFTYSEYLSVAFSKVWTKKAFLPSRREMWRMHEERVKDRGGYGRYFQFLGAARTDENIRYFMAWLNTAAAKYGGRKVDSLPRGTSDIGQYWIKARYGDLNFRFNFSALQPLGVVDTALDMLSEEERSEAVYDAVFGDWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTM0</accession>
    <name>A0A401GTM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0800730</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616469.1">
        <property type="nucleotide sequence ID" value="XM_027760668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTM0"/>
    <dbReference type="FunCoup" id="A0A401GTM0">
        <property type="interactions" value="726"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTM0"/>
    <dbReference type="GeneID" id="38782473"/>
    <dbReference type="InParanoid" id="A0A401GTM0"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="523"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1179"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="267"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="426"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="749"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1186"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE85556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1207" mass="135233" checksum="A795D0006716F981" modified="2019-05-08" version="1">MRIEELVLEGFKSYPVRTQITGWDSSFNAITGLNGSGKSNILDAICFVLGITNMSSMRAQNQQDLIYKRGQAGITKASVTIVFDNSDRATSPVGLENCKQITVTRQIALPNVSKYLLNGHKSQQHTIQTLFQSVQLNINNPNFLIMQGRITKVLNMRPQEILGMVEEAAGTRMFEERKDKAKKTMGKKEKRVQEITSLLEEEITPKLDTLREEKRSFLQYQKACSELERIGRVLRAWEWTEGRERVAKKEAEIAATEKAMTDLRKGKKKCGKEIEAAERRAEEVQAQREKELRKGGKFKKLEDEVGELEKVLVKIRTQVEIKTGTISDEDGKADGKENELKELQETLEQKRAQVDELTTSHGAVKDKHTALQTALTNAEELLQTLLTGLSSSGASHTGGGYMGRLADAKVRLQQASTEEEQSRVKLAMNQKELKALQVRWKEVEREAGDSQKKLQNMKAEIETFQRKVAETGWNVEKERDGENALRTGKAEVRHLTEERDAIKQRLSFLNFDYSLPHANFNRSNVKGLVASLVSLPAADYNKSTALEITAGGKLYNVVVQNEQVGKDLLSNGKLKKRVTIIPLNKIDAFKISAQKIQAASRLAPGKARLALSLVVYPEEVANAMAYVFGNTLICDDPESAKLVTFSPQVGVKSVTLDGDVYDPSGTLSGGSAPSGNGVLIRVQELLDSERKLCEAQGRLQELEQTEQRDRNGRERWKKMARELEIKEHEMHLLEEQVGGSNAARIGTEVDKVKQTITELQTALETAQQKQKDATAEIGKLEKDMDEFKNNKEGKIDELKAGVSKQKASLQKHAVVVKTKQKELQTATLELEQLEKDIETATETLAEARASVEKLRKELGKLKEQLVTNEAAFAKAERKLQDERATLTGFDNELKELGLVIKEKKQAISDADLEIKKLEHDVQTLAKEKSQANNLVANLEKQYDWILDEQESFGKRGSQYDFTAVDVALLKEKARDLEAQQKGMKKKVNPKVINMIDTVEKKEASLKKMLGTVLKDKEKIEQTIEELDRYKRDALEKTWTKVNGDFGGIFAELLPGNFAKLQPPEGQDLTQGLEVKVQLGSVWKQSLTELSGGQRSLIALSLIMSLLQFKPAPMYILDEIDAALDLSHTQHIGQLLRTRFKGSQFIVVSLKEGLFTNANVLFRTRFRDGTSIVERTAQRSTSTLYATDKENDGGEPRSRRPRATMSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU46</accession>
    <name>A0A401GU46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616650.1">
        <property type="nucleotide sequence ID" value="XM_027760849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU46"/>
    <dbReference type="GeneID" id="38782654"/>
    <dbReference type="InParanoid" id="A0A401GU46"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="106" mass="11377" checksum="F83E10570342583C" modified="2019-05-08" version="1">MKPPCQTRGLRSSSLLLDGMRHPPPPLGLPPALLRPLLSDAQDAQHEDVPEHLNEAPASNAGAPFVLVVARRVTPTTSSWPSPGSPPPSALEQTMRPARRHARTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU52</accession>
    <name>A0A401GU52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616649.1">
        <property type="nucleotide sequence ID" value="XM_027760848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU52"/>
    <dbReference type="GeneID" id="38782653"/>
    <dbReference type="InParanoid" id="A0A401GU52"/>
    <dbReference type="OrthoDB" id="2728951at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="397" mass="43934" checksum="ABB6ADB9129232AA" modified="2019-05-08" version="1">MQKLWDHCRDTPLPEGKEEEADDAGFFCLQEGDMVFARDMFGSGRMEDDVIQYWWSPKDQLPLEERSAFTDARALGLGSRELRTASKPELVDGSWTGGVAWERDTQAKPISGSARCYTLRQSYESQKNLSAPVPGAKIFEECVNEHQKMCKTIIQASSHLAMSAFKHAPPYLKQALKCQADVTNLPPLGHSGNYAFPMQQINISATKPSNTLAIAHFKGDLGKFAGKHIDHQDAPEGVTCMHSHSDLDEDDHPGLFYLPEIGAYMVMRGMISVCFSGLRFHGGTPPTSPSDREPSPYSYRIVVVNYPPSALINADGLVGFTSMPNGSLLSLRPEMRDLIYNNPSAFTFSNHGNWGTDGLALTEHCAMFNWYARAMAQFSAYLLRGLPSSLAADFYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUH1</accession>
    <name>A0A401GUH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0803900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616781.1">
        <property type="nucleotide sequence ID" value="XM_027760980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUH1"/>
    <dbReference type="FunCoup" id="A0A401GUH1">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUH1"/>
    <dbReference type="GeneID" id="38782785"/>
    <dbReference type="InParanoid" id="A0A401GUH1"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE85868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="584" mass="63385" checksum="22871EFFC2951B00" modified="2019-05-08" version="1">MAPFHDDDSEAPEYNDRAYKRQLGGWLSYAFASEVFVIVSLTLFLPICLEQFARDNGFLLPDRTQPCTSALPTPAKAPKGEEERCVVKLGWMWIDSASFSLYVYSISVALQALTVISMGGIADHSAHRKRLLLAFAGLGSACATLFLALPSSSPVWVLAAPLAILANVGFGASIVALNAYLPALARGTKEVIATRTALWRLNNAHPLDLSDDSPSLECESEHPEEEAQPHHPLLSHQVPATDADVVAAKAAHDSALSSATARISAQGIALGYAAGIAMLLLALVPVRMLGGSTFALRLAVGLSGLWWALFSVPAAIWLPGSSDIEPKSSLSLADGEAGGIEEGERERWNTWREVRNAWRRLGGMLQWREIRRLRNTFVYLFAWFLLSDGFTTITSTAILFAKTTLHMTPFSLIIIGVLTPTAGILGSLIWPVLQRRAGWTNLRILVTLVGMGSAIPAYGCLGFLPIFQKGAHVGGLTTPGEMYVLAVYFGSVYGAFQGYARAFYAELIPPGEEARWYGLFSITDKSSSFVGPLIVGLIADTTGNIRYAFFFLVLMIWLAIPALMSVDVERGREDARAYTYHLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUM6</accession>
    <name>A0A401GUM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0804130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616802.1">
        <property type="nucleotide sequence ID" value="XM_027761001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUM6"/>
    <dbReference type="STRING" id="139825.A0A401GUM6"/>
    <dbReference type="GeneID" id="38782806"/>
    <dbReference type="InParanoid" id="A0A401GUM6"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="163"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="310" mass="35384" checksum="9B6BF4BBE04AC971" modified="2019-05-08" version="1">MEFDTEDYFNEDQRDVHVWCSRVDIDCMLKLVAVNVFYQWLAMIINLNRSSQFDTLVLVPCKDPRLLSRTNHRSFFSSPSVDQHLPQDSTALLNPGHYAPYKLSDDNLIPVSIELHKLLCSSKHEQRRGPLKPASSASPSPKNDSERRSNKTRKTVRCRDKRCVVTGEEALRRNRGYNFTGLEVAHIFPLAFTGDATAMAAMPHDVAEQLKDYKSADKPENAMLLRADVHKLFDNYQFGIWPTDGTLYRFERSGAPVIGRLPSDDVSQELAVLKAHGISSQFFIEHFRVCLSWHVRGHGRRRGADDLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV09</accession>
    <name>A0A401GV09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0805440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616933.1">
        <property type="nucleotide sequence ID" value="XM_027761132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV09"/>
    <dbReference type="STRING" id="139825.A0A401GV09"/>
    <dbReference type="GeneID" id="38782937"/>
    <dbReference type="InParanoid" id="A0A401GV09"/>
    <dbReference type="OrthoDB" id="2756551at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="131"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="240" mass="27015" checksum="37164F8536815AE3" modified="2019-05-08" version="1">MSQQAAPAASKPIRIFTLPDSGMGKAPIAIGRHHASWFLCFARFDGVDGRRTWKCLNVVHGSETFLSDSADGHPRIVLNDGGRFGNEDLLQDLLKMRDYNGRAPIKLTAERVGGQPVVEVLVPRTELIYACAHCGKWETRGAPRFKRCSGCCARLYCSQKCQKADWTPALHKADCFLLKIGEDHAVEQRRRLHDNDWGLHDLIRTMELGPSADTSYDEDLDSDEIYFFGKRACTRELHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVA2</accession>
    <name>A0A401GVA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0900030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617039.1">
        <property type="nucleotide sequence ID" value="XM_027761238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVA2"/>
    <dbReference type="GeneID" id="38783043"/>
    <dbReference type="InParanoid" id="A0A401GVA2"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="131"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="381"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="533" mass="56388" checksum="741A21FB6F8A9517" modified="2019-05-08" version="1">MESMGGAASSDPASENGTETIELTTRDKTTEADDRKGPDLVYSPADDSDGDSGDEEEGNRALLGSHRGEQEPDGRTTPSRLSTWAQIKSLVIETSPTLLITTAPELFTGELLANVSHWKAMSRVDELIIIVPVILNLKGNLEMNLSARLGTAANMGELDDPSKRKSIIIGNLTLLQVQATVVSFVAACVAFLLGRVIPRPAEEEAAEAVLAGNITSSLMASALEARTPRPAFPGGSPTSGFSEFAMVASAAMTSTCLSACVFGSFMCTLVVLCRRFGLDPDNIAPLVASCLGDLVTLTILGLVSALHLYIIDTVIPLILIILLVAAGVGWTILTHRNEHVKHLLTEGWLPLFGAMIISSGTGLVLDRFVGQYIGYALVAVVATGLSGGVGSVFVSRLSTALHAATSALPTVLSDLPAADEAYEKSPHPSPRLVMVTLLLISLPVDVAFLATVFAFGWLRLSVLFMVLQLVFFGLTVAVSLLLARVTTDFLWTRGLDPDVWALPLNSALVDLVGQLLLVCCYEIAALLGAHVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW36</accession>
    <name>A0A401GW36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycosyl transferase 48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0903100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617344.1">
        <property type="nucleotide sequence ID" value="XM_027761543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW36"/>
    <dbReference type="STRING" id="139825.A0A401GW36"/>
    <dbReference type="GeneID" id="38783348"/>
    <dbReference type="InParanoid" id="A0A401GW36"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl transferase 48" evidence="1">
        <location>
            <begin position="3"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="32108" checksum="68BAFDD6B73C588F" modified="2019-05-08" version="1">MAHRRSKFRIELPGNPVLDDGKSDNQNHAIIFYCGEYLQLIDANPDNYLEECLKIRNVLGEFEEYAVSCQSLYAQWGHKEFKKNPVTFVGAHEYIFSKNIGILDDLAAGKEQTFGTLTARSLAWIGAKLHYGHPDFLNAIDMNTRGGVSKAQKGLHLNEDIYAGMTAFGRGGRIKHMEYYQCGKGRDLGFSTILNFQTKIGTGMGEQMLSREYYYLGTQLSIDRFLTFYYGHPGFHIHNMLIILSVQTSGKTSRGNNLRFCIMPATSANFCLTVNNRAYSASFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWC9</accession>
    <name>A0A401GWC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose transporter</fullName>
            <shortName evidence="5">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0904000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617434.1">
        <property type="nucleotide sequence ID" value="XM_027761633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWC9"/>
    <dbReference type="FunCoup" id="A0A401GWC9">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWC9"/>
    <dbReference type="GeneID" id="38783438"/>
    <dbReference type="InParanoid" id="A0A401GWC9"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="372" mass="40276" checksum="49D0C1F31BA5A0D9" modified="2019-05-08" version="1">MKEEEEDVVEIKKYLATGPGAGREPSSSVSAVPPIVCYCLASIIMTVVNKFVVSGRQFNMNFLLLCIQSTVCVACVMFVKKLGIISFRSFDTKDAKMWFPISFLLVLVIYTGSKSLQYLSIPVYTIFKNLTIILIAYGELIWFGGRVTALTFVSFIMMVISSVIAAWADISDALIAGDPAVAESISMGRLAAVKGIVTNLNVGYFWMLVNCLTSATYVLAMRSKIKAAGFSDWDSMFYNNLLSIPVLVVFSLIAENWGYENLNRNFPAETRSFLLFAIGFSGAAAVGISYTTAWCIRVTSSTTYSMVGALNKLPVAASGMIFFGDAVTFGSVSAVGVGFFAGLVYAVAKNNQKKAESVAQQGVGIIPMSRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWD6</accession>
    <name>A0A401GWD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">NAD-dependent protein deacetylase hst1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0904170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617451.1">
        <property type="nucleotide sequence ID" value="XM_027761650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWD6"/>
    <dbReference type="FunCoup" id="A0A401GWD6">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWD6"/>
    <dbReference type="GeneID" id="38783455"/>
    <dbReference type="InParanoid" id="A0A401GWD6"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="11">
        <location>
            <begin position="184"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="569" mass="64013" checksum="02A1183CC75E794F" modified="2019-05-08" version="1">MDRVSSATSSSPPGAMPSSSPGLHSNRRRLSSIYALQVQAFLDAAEVVDADMETIEDILDGYREDAPAEQAGAADATDVGLGYLDGDEPDLDVELEDMTDFDVQLREAQTAWTKEQTKEMMTWLKEFGMGSFINEYVVTNAIPIPKLLYAFGICLCKELREKRTKTLLFFLRVALSRELQSREKLTAYNTIEDAVTLIRRSKRILVLTGAGISVSCGIPDFRSRNGLYAALQEKGEYDLDDPQQMFDINYFRENPSVFYSFASKIYPSNFIPSPCHRFIKLIEDKGKLLRNYTQNIDTLERQAGVQHVLQCHGSFAIASCLNCHVRVPGSEIEDDILNHRVPLCKICNAAPSRPASNNERKKKSKRRRASRWNSDESDGSEEPDVPEFPPGIMKPDITFFGEKLSDVFDRSLLEDRQMLDLLIVIGTSLKVSPVSEILAHLPHSVPQILINKTPIKHINPDIVLLGNADDVVQHLCRKLGWDLPDPRPHTNGGSLGTATRGNPRKRLSESPEPQRVADTHVWLFEGAEGGKWVEELERKAEKSLPNTDSRESTPFERSLRRQLKKTRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWG3</accession>
    <name>A0A401GWG3_9APHY</name>
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        <submittedName>
            <fullName evidence="3">Leo1-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">SCP_0903880</name>
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    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GBE86509.1"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
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        <property type="entry name" value="Vma12"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
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        <location>
            <begin position="220"/>
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            <begin position="754"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="775" mass="85946" checksum="ABD296CE96B1D036" modified="2019-05-08" version="1">MQTTRRPASTQPDLVLSLEPHLINVLRPLPPLLPPELASQLSTVLPPDGPVSSPTISYALLSSISRWARSPTGEVALRSHYPPLQPHDYAMVPMLAGARTSPHRKFPSSPASDSQAVVSRQELNDRRAITALVNALLSVGGSGAATWWAAEKLAWKDEWKVSLALLVSLVVATSEAILYIIWEARRSKVSTRNGVAVHTDPRASAPSHEKECDNVATSTAVNRVDATKEGMERPSATNERFQWTPPSPSHHRDHSSEMSLADALVSPVPQTQAHHLEDVDDPSSPEDVVAEDEEMHDLFGEDAEPVLTKTEDSATPASSEPIDNADRLSSPERKHREAMEYAEGDEPEHVVEQVLEADAAIPNIPVPRSSDGNFWVIRMPNFVKVDSKPFHSDTYLGPEQEDEEAQLPETLREKSMSIKLKVENTIRWRWVKDENDGDRRQSNSRVVRWSDGSLSLQLGKELFDITQTIDTSGAVPRQAIGGSQPQLPSQSVPPLSQQSQSASGPAKSQGLTYLVAQHKRAEILQCEALVTGYMSLRPTGMQSETHRMLVRAVGQKHNKVARLRMAPDPTVDPEREKMELLKIASRKPKKARGEDDGLGGTRRRRANYSRKRTGDDMWSDDEEEAVFGGASDEDYDGGATASKAKRSKMSSQESKKGPGEYQTDDFLVADSEEEGGDSDGGRRKRTRSRTQHHEEGRKDDLERLEAKIDRQEMEKKRRREASDNTIMPGVSELDTGEAMMDVESEEEDAEFTVRRTRSVPGARKRRAIEIGDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWM5</accession>
    <name>A0A401GWM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0905070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617541.1">
        <property type="nucleotide sequence ID" value="XM_027761740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWM5"/>
    <dbReference type="STRING" id="139825.A0A401GWM5"/>
    <dbReference type="GeneID" id="38783545"/>
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    <dbReference type="OrthoDB" id="2591449at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="560" mass="59599" checksum="32ADAE6B9D13C9CB" modified="2019-05-08" version="1">MPRTLHNKDIAPWGPAPTQTASSSAMSSSSSPSNSPTRARRVSARRGSVSASDPWGAYASLNNPARAMSSRLTIVRVPPPHEDDSTPSRRHRRHGSNASLSSTSSKGEPSRLSFAFASFTQPPSPGAGPSPGSQPPRPASPGSPRMAPTLTRRYSGSGVSAFSNQQKLSPDQLVELARQSCHPRPSTSAGTAPPTPAASAPAPVSFTPLPDDVFLPFVDRPAEVAQLIASPPSAKLFALLAQTFPSMNEPTSVYPDDPKHWSYRDLERWLTIVDRDEASDAEWVAKARACVLSHSELIWERIKGALGVPPELDVEPEHATHAEVFIEEARQRQFDSESALVLGSPEQSFITPFPSRRPVASDVEPDDLLPSIEMQPPSPPEDEVTIEPVLASSAPPPTSSHDLGFSLHEVREEDESEDARTPTSPEVHGLRISTSPTRAPGASVALSSSPSASPLALGPRDDAPYDAMRERGPGHPLFPSSFAQLALAPTLRPSQSARTMSVAYPALLATGGIRRADSVDGVPRAGLRALRNDWAQAWDPARHEFAVASSAGSVSASGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX92</accession>
    <name>A0A401GX92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable NAD(P)H-dependent D-xylose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1000870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617758.1">
        <property type="nucleotide sequence ID" value="XM_027761957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX92"/>
    <dbReference type="STRING" id="139825.A0A401GX92"/>
    <dbReference type="GeneID" id="38783762"/>
    <dbReference type="InParanoid" id="A0A401GX92"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="323" mass="36761" checksum="CFB7B69FE681FAAE" modified="2019-05-08" version="1">MLVSPTIKLQPTGAEMPQVGFGTWKHYGQKASDAVYEGLKVGYRLFDCACDYDNEKGCGAGLKRAIDEGIVKREEVWVVSKLWNTYHRKEHVREAVMRSLKDWGVSYFDIYYMHFPISLAFVPFETRYPPGWYYDGKAEVRLDPVPIRETWEALEELMDEGYIKHLGVSNMNSGLLMDLLSYARIKPSVLQVEIHPYNAQFRLVEYAHSLGIAVTGYSSFGPLGFRELNMKKALDTQPLFTHPLITALAASHACTPAQIVLRWATQRGIAVIPKSGTVRMMQDNMRNVEVHLSEEEMQEVGELDRGLRFNEPADDFAGCYIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX99</accession>
    <name>A0A401GX99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1000970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617768.1">
        <property type="nucleotide sequence ID" value="XM_027761967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX99"/>
    <dbReference type="STRING" id="139825.A0A401GX99"/>
    <dbReference type="GeneID" id="38783772"/>
    <dbReference type="InParanoid" id="A0A401GX99"/>
    <dbReference type="OrthoDB" id="3061923at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="593" mass="62616" checksum="B7B89580E64F77AC" modified="2019-05-08" version="1">MWSYRHSRSRTSPSHRSFADPSEDILFGPGGELSIGTDQDVNSGSDPSPQPQSQNQPQFPAGATSSAMNADNHQPTASESAIQTSVSGASKASADSVSSIIAVLSSTFTSLPETSAILTSSSLTAASSLATHATGLSSPSSSSHTPTSSVASSSSPSADGAASHSISPHTATFDVGITLAALVAAGFFLMLLNWCVRTRKRSKRRALESATAWPWDRDTPGGLIGARDNLETGLGSSIPDDDLGIWVGDESRGPDTLTSAFRQYQVSESHEFSQATLPDSHAYPLPPAHISLNTRLASPYPTVQVRSANSSVPDLAPDLGMLQVANLMPGDVSSDGEASRSNSVLGTDAMFLDYGTLYQPMTGDRPRFLGIDGGGLEVPWAPLHPRRHRSNASYQSADASVTSENELGVLPFPGENEAQTGNETGSWAASIRSNVVNAFNAVVHGNGDDTKAADNLTVSPHRKNRSRTGRGPKSGVGIMSRGSSVHSIVSDTKEWTLEEKSDGTGVVHILLQDAPEQKPVRSPNDDIQKPPAAFVKSRDREVPSSPPYLTRTGKDAEGTATDDVGPQVLILLLRCLRRLGHVEGIEYVFRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXA9</accession>
    <name>A0A401GXA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617778.1">
        <property type="nucleotide sequence ID" value="XM_027761977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXA9"/>
    <dbReference type="GeneID" id="38783782"/>
    <dbReference type="InParanoid" id="A0A401GXA9"/>
    <dbReference type="OrthoDB" id="2747778at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="109" mass="12809" checksum="3BA69DC65CAF6AA3" modified="2019-05-08" version="1">MPMKQRVDDGRTVWERTWTVYPSKMIPVLPKRLRHFEDGFELVLLVYHALCAHQEYYKAGVLHGNVSEENVIIFETPFSERKGVLVDLDQANTFRRPERPDPDLKARNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXE0</accession>
    <name>A0A401GXE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspyridones efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1001420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617811.1">
        <property type="nucleotide sequence ID" value="XM_027762010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXE0"/>
    <dbReference type="GeneID" id="38783815"/>
    <dbReference type="InParanoid" id="A0A401GXE0"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="63"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="458" mass="49337" checksum="BC43B3DA12E6BF61" modified="2019-05-08" version="1">MDASSSEKPQSVYSQAERAVVPSSTSSAKEKADLDTPVIDSSSPVADDDVPADPFDSYPEGGRGWIVVLGCVIFSASTVGWALAWGIVQTYYVEHLFPHTSESVLSTLGSMSGMIMTLTSVITGKLGDRYGYKPFLAAGALCWTVSMLCSAFCTKVWQFFLTQGVLQGIACSLVFPLIVALPAQWFYKYRALTTGIVVAGSSLGGAVASMLMYGMLESLGLRRTFAIYSAIDAVSMTAAFFMIQERRRPQSKRPDIIWFDRTFFMDPVFWSLGLCFLFTTFGYLSPIFYLPTYTSEKIPSASLLLSSLPVTALNLSAAAGRTLIGFVADRTGPVNALFVAIFMSGITQILIWNFVTTYAGIMIFAILYGFFCGCFISLTPAVGAQLYGSGRLAGLSGLLLFFNLPGNSAGAPLGGAILSATNGSWRAVASWSGAMQIAGAMILLYARFKRQPKLFSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXF8</accession>
    <name>A0A401GXF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi pH regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1001140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617785.1">
        <property type="nucleotide sequence ID" value="XM_027761984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXF8"/>
    <dbReference type="GeneID" id="38783789"/>
    <dbReference type="InParanoid" id="A0A401GXF8"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="320"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="56505" checksum="846F3AD6D1DF5584" modified="2019-05-08" version="1">MSTASPGLETCILVFIKILLFFACRGYLLRNLYHDLQDLSAQQTVEPGSPPCSDDANLELTTLPGPSTAVVAVASGRPLHSTLSRSLFSLCFSEICTLFLLLMCQGIDLLDPGVRLINWKVSLWLLLATILVFIPLSYSLVLSGGPSGKGTQPRQRPSVLRALLNILSVGLFLFLLSFIPLPSSLPTSDFMGTTLSRLTVLGTIILGALSGFGAVNTAWNFFPPFYGTLRSHPTEGDIAAAEQGLQRVRRELAQRQSDIQKLQAAQQPNQEASWFSHVVPFRGDSQMSSAMQEMSGLESLEYQMSRNLEALRQRQADANFSRTISGKLFNWGGRIFAIYCVYRILNAIVNLIIPRTAAIPSSPKEPVSTSVDMMSTAIAHLLSLLPSVEISTKDIALISRQISLGLVGVIILSSIRLVLRGVARALRVTSRNLGASLMLLMLAQLMGIYLLSTLIQLRTSFPPPPARPDTEVDQGTVNLFSTLPEYQLFGSLFDGSFLLAAGVSGVGRWFGDRINGVGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXH7</accession>
    <name>A0A401GXH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1001790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617848.1">
        <property type="nucleotide sequence ID" value="XM_027762047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXH7"/>
    <dbReference type="FunCoup" id="A0A401GXH7">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXH7"/>
    <dbReference type="GeneID" id="38783852"/>
    <dbReference type="InParanoid" id="A0A401GXH7"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="11">
        <location>
            <begin position="169"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="418" mass="45985" checksum="687D78903FC233BB" modified="2019-05-08" version="1">MMGAVSCMSRIVPRASHQTICHSQIRLLSSVGLQRARLSVRTEACRLPRSSRNFWWTASKTPTVQEQAPTQEILSVPEQPPADAESFIEGSPASETIPLSPAEPGVDFSAGTDIPIAPLDGVIPDASAITSIAPLQYGDLAALGLVGWSPAGLCRWGMELLQVSTGLPWFWTIVGVTIVSRAVLFPFTVLSIQNTAKLAPYQGEMLKLREKMTEAQNSRDMLLLQNVAMKQQMIYKKCGVSMGQMALLPFVQLPVTLGMFFGVKKLCDLPLEQLKISGLDILPNLTVADPTYMLPVAAAVLMNLQLRVSMADMAAAPHTAHLINLFRVLSMVGVFFMVNLPSGVMVYLITSLSFILAQTLFMRIPVVRRALGIPIVPRHMQSQSATFKESLDFVKQWWKDKKAEQEAAIRANRRNGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXT0</accession>
    <name>A0A401GXT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1002740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617941.1">
        <property type="nucleotide sequence ID" value="XM_027762140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXT0"/>
    <dbReference type="STRING" id="139825.A0A401GXT0"/>
    <dbReference type="GeneID" id="38783945"/>
    <dbReference type="InParanoid" id="A0A401GXT0"/>
    <dbReference type="OrthoDB" id="2799468at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="33812" checksum="6F4CFB2148D867C8" modified="2019-05-08" version="1">MPIRAKSHSTSSHYSPLKNCGQSMSTSSTGSQQGRTSPEVPLIEADVLSKTSPPAPVSSTPRSSGASVALAEGVDLTAIGKAEARKIMSEEHRILRFRPPQGSLAAEAQAAAAKHPDGRPDAAPPDTLRLKALARKDAERILAERKMNTEGATADADGKRVEEKHTPATEGVNLSTISAVEARTLMSHEHRALGFRPPPGSIAAEAQAAAARHPEGDGVVVDKEVLKEIAIKDAERIKADRELDIVGEANVSTFGRAGARTVVSGMTGVLRHSPEASAGLLVAEAACVHPEGANFPQALDGEAQQVAEAEQGEAELSWETEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXZ8</accession>
    <name>A0A401GXZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1003180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617984.1">
        <property type="nucleotide sequence ID" value="XM_027762183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXZ8"/>
    <dbReference type="FunCoup" id="A0A401GXZ8">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXZ8"/>
    <dbReference type="GeneID" id="38783988"/>
    <dbReference type="InParanoid" id="A0A401GXZ8"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="216" mass="24853" checksum="A4041001C60CECB3" modified="2019-05-08" version="1">MASTVAQNQEKNPRGIPKAPFIADVDEYLGPHPDPETSLKEFQAALAKYRYMDHNLAQRRRGLEEKIPDIKKTLTMVEFLHERREGKGRPGEECDEDDDLEDDEDTSSKKLTRTTFELNDTLFAEAELEDTDTVYLWLGANVMLSYKLPAAIALLYDKLKAAEGSLEGVVEDLEFLREQITVMEVNTARVYNWDVKRRREVREREVREGKTDDKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYV3</accession>
    <name>A0A401GYV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1100220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618260.1">
        <property type="nucleotide sequence ID" value="XM_027762459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYV3"/>
    <dbReference type="FunCoup" id="A0A401GYV3">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYV3"/>
    <dbReference type="GeneID" id="38784264"/>
    <dbReference type="InParanoid" id="A0A401GYV3"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="40"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartokinase ACT" evidence="9">
        <location>
            <begin position="518"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="595" mass="64268" checksum="A7ECC548ADD1013A" modified="2019-05-08" version="1">MSDSSPSSSSPSSSPNSLSSESSPSTPPNMHQNTIDPAAKWLVQKFGGTSVGKFAVKIAEDIVSEYVDQHKVAIVCSARSGSTKALGTTNLLLRASSEALQRPNHSTETPGSVTPGMLFTQLARVQSPPDSPRQRSASSPRSGSTSAFGSLSIPSFRPVFSHTVDIIRTEHLVAARSSIRDQEILHELEAEIERDCDGLASFLFATQVIDEVSPRSKDNIVGFGERLACKMMTAILRDRGIDAEYVSLEHIVPLPEEGEASSQTETLGQDFYDRVAEAVGERIRQCGNRIPVVTGFFGPVPGSLLRQVGRGYTDLLSALLAVGLGASELQIWKEVDGIFTADPRKVPTARLIPIISPEEAAELTYYGSEVVHPFTMEQVIRRKIPIRIKNVENPHGGGTVIHPDADLDGPSFPDTAPEALVRALGSSYERKLPTAVTIKERIVVLNVSSNRKSVSHGFLAGIFGTLDRHGVVVDLISTSEVHVSMAIEDAWDKKVLDRVVRELRKSGSVTVSRDMAILSLVGKKMRHMVGIAGRMFTTLGQGSVNIEMISQGANEINISCVIDGRDAVKALNLIHQSCLQIGPEVVKGRVGPWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0T2</accession>
    <name>A0A401H0T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1857-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1202650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618950.1">
        <property type="nucleotide sequence ID" value="XM_027763149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0T2"/>
    <dbReference type="STRING" id="139825.A0A401H0T2"/>
    <dbReference type="GeneID" id="38784954"/>
    <dbReference type="InParanoid" id="A0A401H0T2"/>
    <dbReference type="OrthoDB" id="2320332at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="156" mass="17194" checksum="308CECEBFFCC3732" modified="2019-05-08" version="1">MRALSVTLPVNSPSDSSTLTQAQVYAGLQVKARDATPFVAPIASCEVLREFPTGLVRRVQFKGDPEYKTEQVDFYPPSLMEFTLHESPAYVTNLISSSPEGDLYLTFTFATGPNGPLDESETALETEKTKRRQVAGVIQHTLDVIREMVRSGEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2A4</accession>
    <name>A0A401H2A4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1303060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619403.1">
        <property type="nucleotide sequence ID" value="XM_027763602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2A4"/>
    <dbReference type="GeneID" id="38785407"/>
    <dbReference type="InParanoid" id="A0A401H2A4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="12760" checksum="3ED36CB4F834656B" modified="2019-05-08" version="1">MTNKVLTRWETGLVAADNQKYGSVVQLTAATLRTQVGAVLSMHAPAAGNTQEPTYPLAQDFEAISNTGDLEAVIESQGGNVVGLEFNVLQNSIAHPVEFPLHTMDGDIQLAQLGDIAATIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2W2</accession>
    <name>A0A401H2W2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1401560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619664.1">
        <property type="nucleotide sequence ID" value="XM_027763863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2W2"/>
    <dbReference type="STRING" id="139825.A0A401H2W2"/>
    <dbReference type="GeneID" id="38785668"/>
    <dbReference type="InParanoid" id="A0A401H2W2"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="11232" checksum="EF8ED53899E311E7" modified="2019-05-08" version="1">MAGAFSGHLVDSFLSSQQYCQPLAASSLQIATHGSMSFAPQMHGIPSQSSFSFQPSFMDLSEDTAKRIATLQAKLDKKLGPEYISQRPGPGGGPKLTYAEGTFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3F0</accession>
    <name>A0A401H3F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619879.1">
        <property type="nucleotide sequence ID" value="XM_027764078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3F0"/>
    <dbReference type="STRING" id="139825.A0A401H3F0"/>
    <dbReference type="GeneID" id="38785883"/>
    <dbReference type="InParanoid" id="A0A401H3F0"/>
    <dbReference type="OrthoDB" id="10559167at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="130" mass="15972" checksum="BF5EE56B3B6EA575" modified="2019-05-08" version="1">MARHSQEDGLQCLANKKWKVSKKRFSWCCRYKLRIIQRTEIEKALLKAKRDEHQKTYFQALQEARDEISKQAERLRDVFGSHTTEYYYKEIMQATRLMWKKRKANRWNVYLRKEVQRKNEGKLNQRYSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Q1</accession>
    <name>A0A401H3Q1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619957.1">
        <property type="nucleotide sequence ID" value="XM_027764156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Q1"/>
    <dbReference type="STRING" id="139825.A0A401H3Q1"/>
    <dbReference type="GeneID" id="38785961"/>
    <dbReference type="InParanoid" id="A0A401H3Q1"/>
    <dbReference type="OrthoDB" id="2659442at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="84" mass="9714" checksum="5828185CE79955E3" modified="2019-05-08" version="1">MEHSKEDGTLPPIAPQLLVDMHISRAKEAFMEIDEQVTEEWRLENEIPNTDVIEEMREGLAQKRNRAPSTVVKQPRRKAARYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H450</accession>
    <name>A0A401H450_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1501890</name>
        <name evidence="2" type="ORF">SCP_1502020</name>
        <name evidence="3" type="ORF">SCP_1502060</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620094.1">
        <property type="nucleotide sequence ID" value="XM_027764293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H450"/>
    <dbReference type="GeneID" id="38786098"/>
    <dbReference type="InParanoid" id="A0A401H450"/>
    <dbReference type="OrthoDB" id="3357224at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="368" mass="40545" checksum="65C2D072604868F0" modified="2019-05-08" version="1">MAQRCSQRVVMPTRLAGVPRSVYESTSTPVGLWRAMLLVRSSACKLYALPVGFMPVIESISKKVVDTEFPPRYLSKASRNSIFKKQRIDVELSCADTALPPLAEDAEAEACSGYIPPTQRAVQEANEDLDQDGGSKVVDIPDMCLIFPDDGYLEVFSAGREGVRRSCGHEVLGTAACSVTPEPIDYEGLTAQLTQAVKPHISQLIDFAPDKRGTAGLIVDSFIPILRSLHAEFPTFDATRRLIVGRLATEVRKMRSRSRPLLLNTKMTCCTNMSIVQFEPEPLSLRSQWLRSAWGPDVFSSSLCICKKGLYRAVRGPIVSRGHVDRHHQSTVRQTCSGEGAEVEVECFREATTERPGPLRTVGTRTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H456</accession>
    <name>A0A401H456_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620138.1">
        <property type="nucleotide sequence ID" value="XM_027764337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H456"/>
    <dbReference type="STRING" id="139825.A0A401H456"/>
    <dbReference type="GeneID" id="38786142"/>
    <dbReference type="InParanoid" id="A0A401H456"/>
    <dbReference type="OrthoDB" id="3245901at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="258" mass="28534" checksum="C4D8BCC12B5257A9" modified="2019-05-08" version="1">MDHVYADEACSSPDDFHFLYDLQGPQRNPSDSLPPAPPSLQPSVPGSEFPVTYIQSTYSSLTDSCCPSPVNSSFTPFAPYPLASFTEQLPATSLAPDPTYCFQAEEKPYAKPSPSSPPARTITSRKHEGSKRRKVWSHALEKALFTPEEICTMGAPHRRTIYTASLEAHIDRLHHQLLDYSLFPIPFEKLESFRGLDSRTAKSMIAGLQHDASELWLKHLELQCTNEALRDVLRAHPGILVPPVDNPSALGRSAPPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4F9</accession>
    <name>A0A401H4F9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620231.1">
        <property type="nucleotide sequence ID" value="XM_027764430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4F9"/>
    <dbReference type="STRING" id="139825.A0A401H4F9"/>
    <dbReference type="GeneID" id="38786235"/>
    <dbReference type="InParanoid" id="A0A401H4F9"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="946" mass="108272" checksum="7EF060440DC712AF" modified="2019-05-08" version="1">MSQPDIDYLMELWGLSLMKHGSLGPFDSYDHMYAVIDEIGEGSAPWKCFVSQGEENLPPNAPNWRREEYQIWYRDPQTVIANMLDNPDFTGEFDAAPYIHLDPSDKRRWGDFMSGNYPWRHSKTQIFEEDPSTEGAMYVPIILGSDKTTVSVATGNVEYHPLYMSIGNIHSSVRRAHRNGVVPIGFLAIPKSDRKYDKDPAFRAFKRKLYHQSIASILSTLTSGMCTPEVRRCPDGHFRRVVYDLVAFIADYPEQVLLTGIVQGWCARCTAFASDLDGSEASGRRSKDLTSDLIQEFQGQGTLLWDNYGIDDEIIINIHEMISSDLLHQIIKGSFKDHLVTWVGEYLVTEHAEKRANEIMDDIDRRIAAAPPFPGLRRFPHGRCFKQWTGDDSKALMKVYLPAIAEYVPAEMVRALSAFLDFCYLMRRTDFDEETLAAVQNSIQRFHCHREMVCEKTSLCLDNTLSYTTQTIYENLEHQMPWRRSSRYNALSQMLLTNQHLDKLAALRTHFVERGILAPARLPPPTPFDNDEEEAGPINDDRVLAEVILARTRERSYPRYLDELAADISQPQLPVLTRRFLYDQIHRHDPDAISSNVVELDDCPIVINKISVFHSAVAIFYAPSDIFGIHGMRLSYTGIRPDDNVPPWMEEEYEVWFHCPHEVVRNQLANPDFAMEMDYAPKCFFDKDNQHEYKDFMSGNWVWNQADLIAENPSTHGAMFCPIILGSDKTTVLVATGQNEYYPLYLSNGLVFNSMRRAQCNAVSVVAFLTISKTDRQYQDDPKFRKFRHQLFHSSLNQILQSLLPEMTSPEVTRCANGHYRRIVYGLGPYIANYSEQVLLACVVQEWCPRCTSHSENLDADAPRRSHTHTSALLDVFDLKTLWDDYGVVGDLVQVFCTFKDHLVTWVEEYLIIVHGKASAASIMADIDHRIAAVPSFPALRWFPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5C2</accession>
    <name>A0A401H5C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1603020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620551.1">
        <property type="nucleotide sequence ID" value="XM_027764750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5C2"/>
    <dbReference type="GeneID" id="38786555"/>
    <dbReference type="InParanoid" id="A0A401H5C2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="163" mass="19183" checksum="212C4259EE5D2102" modified="2019-05-08" version="1">MFLTRSSRSVFSARPRVLPRWTPRRSIWGSREARTQPTSTTSVVDSDVVVFTKEEYNSMMDDIRMIDRHIDRLERRALNNFTNLAEEKRDELALKCGFRGWDHLSVAMETYPQVDWEAVAQRKLAERGVDVPLEELRMLLKDDVTDVMYQQNRLPALYQFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5U5</accession>
    <name>A0A401H5U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620674.1">
        <property type="nucleotide sequence ID" value="XM_027764873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5U5"/>
    <dbReference type="GeneID" id="38786678"/>
    <dbReference type="InParanoid" id="A0A401H5U5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="10578" checksum="0EDF54758162E862" modified="2019-05-08" version="1">MALGPSSAHQLLATEPRAERAGLSRTRAAQLECAITAARARAPSSKLAQLPRIDLGPCAALFVRATCGYTVREAPPRSNIECGGAQPVFYLARAVFGADVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6V8</accession>
    <name>A0A401H6V8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1900010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621065.1">
        <property type="nucleotide sequence ID" value="XM_027765264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6V8"/>
    <dbReference type="GeneID" id="38787069"/>
    <dbReference type="InParanoid" id="A0A401H6V8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="455" mass="48954" checksum="E697CBE85A761809" modified="2019-05-08" version="1" fragment="single">MSPWLHLLPPPRAPPGRRMQTFGGAFVFGELEAVQRRHCRTGHLGATAAHNVVFAVTLAPRCRTPAPCAFLRPSSTLAGPPQRTMAPRSSHWPPPRAPPGRRTQTFGGAVVLGGRSEVQSRRCRASHRGATTSCSPFLAVAEAPRNTSPPPCVLSRPSSNRAGPRWRTTATRWSRQPPRCDEGSQPQLQHCQGPARPRAASLHLPAPSIGRLRPAQAHGGERQPRGATTAAPQVCQGPGQPPSTNPHPPSALFHPRRPTETNDSGAVVVSATAVQRRREAPATWSPKPALGSPRPSPRTSPLHPPRPFARATDTRTAMQHRAAARGRLDAARHQPWRHLLPPPRAPPGRRTPPFGGTFAFGGRRVFQPLRCRASHRGVTGARCPLLAVAEAPRSLNPPNSTSLHPPSTVSFARRPTTMNDGAPVVTPASTLRLALPQAVERKRSARLFSKVEGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H759</accession>
    <name>A0A401H759_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_2100020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000021">
        <property type="protein sequence ID" value="GBE90276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621189.1">
        <property type="nucleotide sequence ID" value="XM_027765388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H759"/>
    <dbReference type="STRING" id="139825.A0A401H759"/>
    <dbReference type="GeneID" id="38787193"/>
    <dbReference type="InParanoid" id="A0A401H759"/>
    <dbReference type="OrthoDB" id="2742885at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="313"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="628" mass="71695" checksum="BE44B8487064B28C" modified="2019-05-08" version="1">MINRGKEALVLSNKWETLYDRLTYRGRQELCTFRGELSLGTDKFNDVFDEECRDLQMKKDVVDGKPKTKLPRKIQQLLSRYKGYSKRLAQAERQGSADADHLRVLYSRARNKFRKEQGQWKAKQRELEYSRIADDMASYDFKSAWTRLKARTNLSSSTGEGQPMKPSQPLKDDKGHLQTSPEGIQKVMSDHYKKLLQDDKDGQMRDYEYWRDKFPYQDEVSRDYEHLGLSAPMEWPECLSSIREMNGGTSPSEDELHIDVFKGMVGEECMAELKIRNPQFVRKDNIQVNLPKKLLPMQPRTPMGKVVFHLLNSAWELGDIPEAWEENTIVSLFKKGDPELPNNYRGVTLISVLEKILTGVMMARLYGTLESAEILDPEQAGFRPGEEAIGQFIALAEIVRRRGVVDEKLRITPTFGIFIDFKKAYDKVPHGMLWVACENMGIKGHMLRMIKALYKRTRVAVRAGGGNAEAFDLWRGLRQGCLLSPILFIIFVTNLLQYIRYQDVEHGVDVPHKMIWDKNQARCLGLLYADDVVGFEGSIEYSRKFISNLYRWSKDFGMEIGYDKCGIMLQRGGQVSPIGASGGTVLPAGFGFPASPQTRGQHCQIVPEHPKARCAAHRIVIEMGTSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H768</accession>
    <name>A0A401H768_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_2000070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000020">
        <property type="protein sequence ID" value="GBE90264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621177.1">
        <property type="nucleotide sequence ID" value="XM_027765376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H768"/>
    <dbReference type="STRING" id="139825.A0A401H768"/>
    <dbReference type="GeneID" id="38787181"/>
    <dbReference type="InParanoid" id="A0A401H768"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="137"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE90264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="454" mass="50778" checksum="1B49073649F2C930" modified="2019-05-08" version="1">MEEVLKQYPKPAGLEKIQFDHVPIFSVVGLQLSMFQEPWSHGVPVVVTHIDSVFQGNWGPAYFIESYGSRPVVVQDCETETTRNTTVKDFFMNFGISDRRSSILKLKDWPPQKAFSTEFPELFKAFIDAVPCPDLARLDGVLNLAAHFPLNGLAPDLGPKMYNAFASPQDNEHHGSTKLHMDVTDAVNIMLWAASNHDEKAGSALWHIFPASSVAVLRNFLREHGFTALGDPIHSQSMYLTPGLLDLLATYGVRPYVIHQHPGQAVFIPAGCPHQVSNEVDAIKIACDFLSINNVRETQEVVSQLRYQRLQSGFGDDVLQFFTTLWYTWKSLSHMSELVAVPDVFIVGGDTHSEPPATSEDILAEEQENALSFDTLAITSPGTRQIHEICSPTASHLTQGRDTLSHLEEKKKRRKEKKHAKARSQRPQKPGFDFTCPIPHCAGYYHRAGLLDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G568</accession>
    <name>A0A401G568_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Target of rapamycin complex 1 subunit mip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0101730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608213.1">
        <property type="nucleotide sequence ID" value="XM_027752412.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G568">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G568"/>
    <dbReference type="GeneID" id="38774217"/>
    <dbReference type="InParanoid" id="A0A401G568"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="106"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1402"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="917"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1016"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1089"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="917"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1026"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1545" mass="172717" checksum="E60F122868C2C30C" modified="2019-05-08" version="1">MFGIHGTEGANGRRSDGAARHGSDMDSSTERDFRSTSRSDPSSAQTRAVNSAYDQDARLAGSVATLPDNTPILPHWSAKRHLTCGNPTPPPSWAPKMTPWRPTPGKLKTTNAILVLCLNIDVDPPDVVKTSPCAVLECWVDPHTMPSQKALQIIGANLHHQFEGLSQKMYYKPLLDPAFDDLRKLCQAMRKQAKDDAILFYYNGHGVPKPTPSGEMWCFNKNYTQYIPVSLQELQGWLLSPCVYIWDCSAAGHLLQNFINFARKRDTDVAMNRGGYPEGTPPFSESIQLAACTADEQLPSCPELPADLFTSCLTSPIDIALRYFIMTHQLPNDITADMVMQLPGDLKDRRTPLGELNWIFTAITDTIAWTTFSRDIFTRLYRSDLLVASLFRNFLLAERIMKNYHCTPHTYPPLPPTNTHPLWASWDLAVDSCLRQLPELLKHAKPRADTDASLTVHARRQTTQSGEKTSVGEQPYTYTPSRFFADQLTAFEVWISRGGSALTKRGPLSLPETNGDASFEMADIADSTNLPQDLAQHHLVPRRPPDQLPIVLQVLLSQPHRLRALILLSQFVDLGPWAVYLALTIGIFPYIARLLQAASHDLRPVLIFIWTRIFAVDPTCQIDLYTNQGYKYFANVLSMDDPRHLAFPNRSEHKAMCAFILSAISRDYPQGQDACWREQVFDSCYEKLSDDDFLLRQWSALCIAQIWDANADIKVYGVDRGAQDKLIAMLSDDSAEVRCAALYALGTFLGASGSADMQKLGGGGSGTMYQFDERIHFRMEVAVVTGAALAIRDDASPMCRKELLVLISCLVKEWRGYFIVCAWIYWEEDRRWREREGHPHHDDVASQAVAEWLDGFGDDEAFREENRVFFSSFLTIFCILLELSVDSYQEVATNAQTVIDYILALLLESPFSRLDSTTLNRPPSSSSHLSGTRTRAPSLSSQGLHRPPSPTISRPGMTRSDTMASTISNGVTSTLRRTSSFANALKSLAGNIAFPTMEDGHSSPKLTSTGVTISDVNAVSRPPSPNLNYAQYTSPYSRPSTPQQTHYPQKSSPNPSPRSSLDSQHNDYLPSDVMEALMEEDWERLRARRRTETRHRQGHQGHGNHQQGSYALGAMSSPSGSTFSMDSNIILGLGTGVGIRDVLPLKSRFYDWCCEYFKEPQMRQPEVDEPGSLQYNYQVWRQQRNEHVIAQTRTQAETAGSCKWDRPVSTIQVAGLPLTMAFHAFDPHLVIASETDVITVWDWLQRKRLNYFFNGNPRGTSITSLHLINQDVGGIILTGAADGVIRLYRNYDPAVCNGHVQMVSSFRGLNEIIQMPRSSGVVTEWKQNGGNLLVSGSSRIVRVWDAHTESQVVDLDTNSDSPVTALVCDVGSSHTFLASFADGTVKVYDRRLEEEDAVVRSYNEHTSWVQNIKWHPSFSGQFLSGSMDGEVKLWDMRGGERSMQTWDMFPQGLSAFDVHEQTDVFAATSSPTTTNWRAQRTEVHSFTRATPLTALATQLTLPPPREPSLPFVTRSSSLVFHPREMVYAAGFWDGAVRIMGCKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G594</accession>
    <name>A0A401G594_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein alpha-4 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0102030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608243.1">
        <property type="nucleotide sequence ID" value="XM_027752442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G594"/>
    <dbReference type="STRING" id="139825.A0A401G594"/>
    <dbReference type="GeneID" id="38774247"/>
    <dbReference type="InParanoid" id="A0A401G594"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="356"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="456"/>
            <end position="459"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE77330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="546" mass="61780" checksum="3593F39F88521253" modified="2019-05-08" version="1">MLRDKPTQPVQRQRPPPRPDSDPLAAVLLPPPDETPDARERRLRAEEEAKQRSENIDRMIRDSERHQRRKKVVKVLLLGQSESGKSTTLKQFQLLHTPAAFHAERIAWRFVIYLNLVRSIRRIIEAIMPEDAQGADDLDDFDSNETASIIITSNGCGPSNASHVPTSAYDGYRRRLSPLLPLEQRLIQQLSDPEDNEEQEPTHLPSPPLHSPSSFSMASTSTATLALSSSAPGRPAPRIMIPNGTVSSPTSPVSPSEELTVRVTSNWKKAFSALGKNQSPKSAHSGELQGWWEDPDDPVHIINRCAPVMSELWRDVRVRHRLAEKRLRLQESSGFFLDEIDRITAKMYFPTDEDVLKARLKTTGVVEHTFSLSKSSEFRGVDWKIYDVGGSRSQRHAWAPYFDDVNAIIFLAPISAFDQVLTEDPDTNRLEDTIFLWNSVVSNKLLANVNIVLFLNKCDLLKAKLQSGVKLKQHMTSYGDRPNDYDSVSKYFRHKFLALHQSFTPNKARELFIHMTSVTDTRKTHTIITNVRDIILTGNLRSSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6C2</accession>
    <name>A0A401G6C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0105900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608621.1">
        <property type="nucleotide sequence ID" value="XM_027752820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6C2"/>
    <dbReference type="GeneID" id="38774625"/>
    <dbReference type="InParanoid" id="A0A401G6C2"/>
    <dbReference type="OrthoDB" id="2756650at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="698" mass="76828" checksum="9F1F8E3000A34DC0" modified="2019-05-08" version="1">MLHEVTSTLCDTCLPTLEEAISSNATEPSAKRHKSSEEVETVPREPGTGGLGIVPVRDATKKQEKTHHGKRGKQTKPDASASSTHSLHPSLSHHSTDAMVSPAWSEVLAAVSPLPAPVKVATYFFPLPFLFSGDGDKIRQYLHSYVHIRGFCHQRLLDLTIGRLPLKIAEWRDGLWGDYGLDERLEGPAVDSTNSVDGGAMSASIVRTTSTSLEHVGAKVNEKHERQQNIRQLFAHSGLMSSYDETVMPHWGFDLVSLAQAETFHAHILWEVHETNWRCELVALDVKLSSSASWGSLQRSHWERQAQVAKVWDSSLFSSAFSVAPAWKQDAAMFCWVPADKEGWEKCWPNLSSFIALAARWPNLPEVLSIYFVLGYPCLNPNCAQLIPISILTMHRTNPQVKAIVNGLLPSRQLLRTSVTMCTVSPAISHLVATSYGVTNACTLGLMFEICTHLTKCLRHLKLLAVQLSPAQAQQCRHEVNALDPPAVLGGADLLPSSSPPATPSMRVPLTPSTLHGSQRSSDSYAPSSPSISSSLSGSHDPTLIAAWGIRRAEYLEFAFKQRAIIDALGIDDGDELSYQQFCPHLRQFIDYPKHTHKQYFLPGDIPIYRVKGSDWMPSVERIDAIGRNVNLNSSSGAGPSGCGGARKHALSDAPDNRRRKVVVKAKKPVDCDIELTDNELDSEIVEIDEGREIIYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6E3</accession>
    <name>A0A401G6E3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0106170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608648.1">
        <property type="nucleotide sequence ID" value="XM_027752847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6E3"/>
    <dbReference type="STRING" id="139825.A0A401G6E3"/>
    <dbReference type="GeneID" id="38774652"/>
    <dbReference type="InParanoid" id="A0A401G6E3"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="585"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="79448" checksum="14FC5E20FA9E9825" modified="2019-05-08" version="1">METFRSFVDQNDVNGVHTSYRALKEYLPDTPTHRTAEMVSIDRQVVVGALTVLVTSGSPADRALAEEILADSTRLGIEAYLLYDAIFQSFLGRGALQDAFTWLNHMHLNPGRCKPQGIHYFSLLRACGTHKNFRFALSIVESKQPPTYATYRTLCKALSRSGYTLSVVELRDLVTSMKSYGVSFDPYLLRFIVDGYSNAGRFDLAEEAETLYFSAFDVHSDLRSADFNKDRRLSVSAKKNGKWSALSLYNKFREEGFCATQSTLQGVLHRTTAIPVLRFWERAFSMQAGPYVWAKIIRNAIEVNRLSTGLDLYQSAISSGIHPTNSMLHPILRALCASGLRPPSDAAVDRACDLYHEYVRLNDTPQTRSESNEAENGSSVNSTQPDAPIYNTLLRALCSSSNTEKYFPIALSLLEDMRSRKLSMDDMTLTSVTVLLMRSSSSFTEALKAYRLVCQSQDRLSPLQMEGYSAILNAYCKLSDRFKKVPPARLYFEIVQDMRLAGHDITPHVYTILLQQLAKLARLDPSLRDQVASSVRRVHDFLNVEASLKPDTALWNQLMDSYQRAGCFLEAYRIWESLYRSHEFDATSISVILDACGYAGQYDTALQIYSDLVDSGFQFDLRNWKNWLECLCRLDKVDEALKVLCLEMGEGAGNVEPDEESVRIVLKFATHTNFEGEARDRVKRYLPHLWKQMSQERRVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6R5</accession>
    <name>A0A401G6R5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0107420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608773.1">
        <property type="nucleotide sequence ID" value="XM_027752972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6R5"/>
    <dbReference type="STRING" id="139825.A0A401G6R5"/>
    <dbReference type="GeneID" id="38774777"/>
    <dbReference type="InParanoid" id="A0A401G6R5"/>
    <dbReference type="OrthoDB" id="2565072at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="647"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="908" mass="96995" checksum="6CE7C3C4090D6A1E" modified="2019-05-08" version="1">MSVMNTDLRSQEDHLRLLLDQRAARADLHGRFPSISEMSDSPSVYSHPRFSPRPPDRSQLDPNSPSFHVTVSSHHAVPPSEPRSPISSLSDRERLNFPNASSLDLDDDPRSSYDSTKFPSEDEEPSPEEDEEDMPRLSVYGPKMRVHSRAPWELGEDEIEEQDEVPLHPKPPKPDSGRRGWGLTKGANEKRPSIDSNRSQARGKQSFETVSSFTSNGGALLALAQASMSSTSLALAPSPQSTLRDKLSLPRLRPRTPSNSHPPSVASSDANDHRQPFSTHSGNTSPMSRYMHTASPTGMSPVEHNFSGPSGRAPHVVQYQEYTHPYANPDLVHRMEDNSQRASPRQRTTSATVSRSDSNATVTDTATTSSMFQSGSFSTASLTPVTSASSVNQSVGEASPPTRGTVMGKGISAPVAVGKLPLQSLPLGVLGSQEGGVKPSIRNRDTRILSGVTGNGFLGWSESSVASSIKLITLEEAQAQARERSRSATANPAISSPSSVGPVKSQVQGGEWDQHSLSSRTRTRTTSAGSSKAKNPTADFNQRAPPLPTDSPYQAQLSGGGVPPRTIARKRSGFMRLFNANRERPSQHSPPPPVPSLSTDTLAYPTPVPQSPVPRKSTTHRVPVPSLSPSLLGEASADGGETVSFETRSEPGSRENGAQRERQLSARRKARDLSIVTSPALPSASAKPAFNPMSVASDKLLVVGHLPTSAAQPSSLLSPSAVPSSAPPGATDFVALSLRPVSTLFSNSFADQLISPGNSSCTRPSLDLDLGTPTTATTVISPLSSDFPSKVYPRAADDKTLPVAISSDDQSSVIQALQEQVMTARSAWQRQIWELEGQVHDLKAEVDEMRSHESESRYCSACGRGGTGRSAAEDSGYVEDLKKAGVKVGVVNRPRARTGVGSRFGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G771</accession>
    <name>A0A401G771_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S16-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0108960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608927.1">
        <property type="nucleotide sequence ID" value="XM_027753126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G771"/>
    <dbReference type="FunCoup" id="A0A401G771">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G771"/>
    <dbReference type="GeneID" id="38774931"/>
    <dbReference type="InParanoid" id="A0A401G771"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="143" mass="15745" checksum="9EA86C95825F9EB1" modified="2019-05-08" version="1">MASVKAVQTFGKKKTATAVAHAKEGRGLIHINGSPISLLQPELLRLKVYEPILVAGEESFGVIDIRVRVKGGGHTSQVYAIRQAIAKALVAYYAKYVDAYSAMELKKKLVAYDRTLLIADPRRMEPKKFGGGGARARRQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Y2</accession>
    <name>A0A401G7Y2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0111550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609185.1">
        <property type="nucleotide sequence ID" value="XM_027753384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Y2"/>
    <dbReference type="GeneID" id="38775189"/>
    <dbReference type="InParanoid" id="A0A401G7Y2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="188" mass="19786" checksum="5B166EC30485089E" modified="2019-05-08" version="1">MYLPTFTPLGADDAFCAPEDRPACVPTAAMRGPELAPSQIHNSTQGTLSQPPQTALGAAAETGSDGGDAALIGARNTLGVALAAAVIIATVALWLAFGKWPRRQWKALRHHRVRKRAAARGGGETESAEVAEHCALGAGCGDKDARVARPDDILEKGTIMAGRKDEEERSGDISEERLVGTYVRVDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G808</accession>
    <name>A0A401G808_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0111610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609191.1">
        <property type="nucleotide sequence ID" value="XM_027753390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G808"/>
    <dbReference type="GeneID" id="38775195"/>
    <dbReference type="InParanoid" id="A0A401G808"/>
    <dbReference type="OrthoDB" id="2564232at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="117"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="269" mass="30371" checksum="F8F9C5E50DBBDD61" modified="2019-05-08" version="1">MVEPVARIRPYELRDRKLVRFMLGKGGMEPLTVANRQVYFNPLVMAVWIGLSCISVEALGWWPNVEDYGLLGYFQPFPVFACVAVVFMVICDWINRPSFEDPTNAMLRRPDLVDIEVYYARSPSSGFWLLEYGEKFVGLIAIDASLDAESEEVIGPTSPPQPKNVKTGKLELPKGTSPSATIRHFYVEEPYRVAGIQNDLLEHAITHAFNSDSTVQNIIAVDSPQNSYIGKALRNNGFQLDKKLGTYGVLRWQNSARILKRKSWQSSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8W3</accession>
    <name>A0A401G8W3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0115050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609529.1">
        <property type="nucleotide sequence ID" value="XM_027753728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8W3"/>
    <dbReference type="FunCoup" id="A0A401G8W3">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8W3"/>
    <dbReference type="GeneID" id="38775533"/>
    <dbReference type="InParanoid" id="A0A401G8W3"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="2">
        <location>
            <begin position="389"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="473" mass="53334" checksum="F96869CBA7302FFE" modified="2019-05-08" version="1">MAEDSLVMRRSKRSNAGNRMEAVLADFRAESNGMDVDEDVDFVVEKDEEDAFESDFESTDEEAQSLADDLAENVVREEERAVRKASRSKLDRVTAAAHAKQKDTFHPLLAQASTSRTAVSAAEKLKRRVSLGVAIDAETGEVVKSAKRKSGRIHTMLNTSATVSRMRDAEEKKSFIQKKVKAKIRAPTQDELIARALDMEEGNIIEHRDYLSIEEEKRKRARLVRTAVQGPLLRVISKVEEVKVKVEPVPYSAAPYHYTYSPTPYSSTAQSPSAQSLPSPSYFHPSATVYHPPQPASTQSSSIPAAGVLPLRPFQHGYVPPNPTVQGVEPVERTEKVSRNYVVHELVQTEDEPRPSWLSTMKAMFGDHVNWDELRVYTAKGRPFARPTQICPMSGRIARYLDPRSNVPFADVAAYSTLSKILAHEYVWCDHLGCYILHEDEQSKLNVLLIIRMHVRCHRYRSDHRIAKTVKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G911</accession>
    <name>A0A401G911_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0115510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609573.1">
        <property type="nucleotide sequence ID" value="XM_027753772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G911"/>
    <dbReference type="GeneID" id="38775577"/>
    <dbReference type="InParanoid" id="A0A401G911"/>
    <dbReference type="OrthoDB" id="3320394at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="466" mass="51849" checksum="C378405643ACE57E" modified="2019-05-08" version="1">MARHGRKSGHLTATWKKPGRPPEQPAELGPDPKLTHLLLKLPPHLPPSRPPVQSLIENYISPSSSSSNEDVLYGAQVTQDDNDDGVVHNSDTDGDDITVTEPASQSTQGDHGKVITPLHAQPVEVEYMVPKHDGKAMKRVPLSSAVTWDIVREWLRIVMGYDNVDDMALSYRLSKDAKSVRKSLEDDNDYQGIVQSMQSHRRNTRPQQVIILDNSVNDSEQELSQPKGSHKKAPGMKAATVAHAYATVEHQSQIDEVVEELKRQNPKCSEHAMSCWLGHPSGEHVQLTEMCFAAWATDIVKQLSLPEMERTVTYTHPSNNRMFDVPPLFHHQHAPSVLKAPSTSMPVPPIIINMPEMSGSHKHLMVSPSSSDPVNSADAPWPSLTDFLLHAVTVDCHSRNYPAYEPGLCQADLLGPDDIEKCTEEELKKHCDIPIGAGRFLIHEAKLVCKQIQQQAQIPQKCFRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G950</accession>
    <name>A0A401G950_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase GET3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0115820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609604.1">
        <property type="nucleotide sequence ID" value="XM_027753803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G950"/>
    <dbReference type="FunCoup" id="A0A401G950">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G950"/>
    <dbReference type="GeneID" id="38775608"/>
    <dbReference type="InParanoid" id="A0A401G950"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="36452" checksum="3A7229E025692FFC" modified="2019-05-08" version="1">MVMATETLEPTLQNVLDQRSLKWIFCGGKGGVGKTTTSCSLAIQLATCRESVLLISTDPAHNLSDAFGQKFSKEATKVNGFDNLYAMEIDPTSSIQEMVEQSDSNGMMGSMMQDLAFAIPGVDEAMSFAEIMKHVKSMEYSVIVFDTAPTGHTLRFLSFPTVLEKALGKLSALSGRIGPMINQMTSLMGGQADAPEEMFAKLESMRAIITEVNTQFKDPEKTTFVCVCISEFLSLYETERLVQELTAYEIDTHNIVVNQLLFPKQSSNCEHCRVRHAMQQKYLGEAHELYDEFFHIVLLPLLTEEVRGPLKLQEFSKMLVTPYSPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G953</accession>
    <name>A0A401G953_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0115790</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609601.1">
        <property type="nucleotide sequence ID" value="XM_027753800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G953"/>
    <dbReference type="FunCoup" id="A0A401G953">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G953"/>
    <dbReference type="GeneID" id="38775605"/>
    <dbReference type="InParanoid" id="A0A401G953"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 20" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="VWFA" evidence="19">
        <location>
            <begin position="10"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="609"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="651"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE78688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="820" mass="93176" checksum="B1C79CE533A42FC0" modified="2019-05-08" version="1">MPAERAGYTVTMFLVDISSSMGKMRQVEIPNERNDEPDIIEMTNLEWSLQFVMLKIQEMIFNSRKTDQCGVILFGSEETDNMINEKNGGYENVSEYIPIAQPNAGTLAKLAALRPSEVIGDPIDALIVGIETQNQYLSSKKTWTRKIVLLTDGENPIEIEDWETTAKKMNSLDIRFTVVGVDFDDENFPFHEEDKSEIKHQNESFFHTFVSSLNNGIVGNCDFALRELARPDIKQVKSALLGTVLRLGDVDARPEDAIEIHVKTSKCTALSRPKSWKKFTRRDRLEDEEEEADNKAPKAVFAQLQMRTEYFVQREGEDTDEENVESEQREEDQKQDNKLKVEKEQLVRGFKYGASYAPCPDGQFPRLVTRKGIDICGFFKERFFRRDYCMGEVSYVWADPTSPMQQVALSSFVQAMYEKGALAIARWVGRDGADPKMGVLAPSMFQNADCLLWVQMPFADDVRNFPFASLDTLISKKGETLAKHPYLPTEEQVDAMEQFVDAMDLSDAGEKDEDGVRQPWYDNRLSYNPAVHRTKQALFHSAIVSDLGMYPLPPPHPELLKYFEPPRRVLKRAHDAIEECNQKFKVKEVPKKIAKTRKDGHVRARDEDEDMLLLDRMPRRTKSQALVSSQLAATSQPRERAEEKKPKRVDDDSETESESEDDQDLLLNDAGGVLPTPARSETGFEAGLRPGRVVGSRHPLKDFHDNLARGDIVTKSVEDLAAVIKEITVRPSESHRMDELLECMQELRKVSCEEDEIDAWNGFLPDLRKLCVDEQPGNKAFWARVKKLGRDISLISKPQARKLGGKSNISEAESIEFIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G968</accession>
    <name>A0A401G968_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0115740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609596.1">
        <property type="nucleotide sequence ID" value="XM_027753795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G968"/>
    <dbReference type="STRING" id="139825.A0A401G968"/>
    <dbReference type="GeneID" id="38775600"/>
    <dbReference type="InParanoid" id="A0A401G968"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="606"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="445"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="720"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="771"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="883"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="899" mass="98574" checksum="E7030ED77BED2659" modified="2019-05-08" version="1">MSSAHISSTPIASPSHAPKIRTGAAAGEVVESGRVESSPRAETTPRARSPSRGGLLPPFGVRDPAHLPTPQSPGSRGAYSTAKGHPPESPLSYGLRTAVPSMTRMASRDKRPVAAAASFITPEPSPEARRRLPLGHQDLASVFANVSVIPTPHTPPLRSQNEPKSGAGTILLTQSPTLSPFPSSRDITPSSGLSSPFMERLSLADRADTRSRTPHDVSVGPAIKRTSSVPMHVDDMFPHEGGISSTPPPLSAPVPKRPAGGEIHRIRLQMVAEQAARQSESEARRPNYLVRERRISSNDASADHDVTEVEQEGLPSGLGVTESPVKGRRLKLFQETSEESFEQSLLAGGYPGYGYTPAYGEPQTPDKKGKNPLSQRAVQWLQQATPGQPGPSNVPSDPESDWVPSEKEILKRKRLAAFQDHPEISEPPKKLHPVEIEGKGRLLLNVLPEDMPSQYETPAKKRGSRRRRRGGVASAKKRGHVTESVPDQGEVLKPDWPDSSFPWCMRVQERAETARLEQEERFKWIDRYLDSDQDSGDEDLNSEPDKEAPPMRTVWGKMVRPSFIPRGRPDVNDDWEGNFDPADARVALKSRRSAREFAMHLRQRASQNCCICEGRRDGGPAVQCDDCDRWFHLECVDIRDPAELEDTWYCADCLGLGQLASDPASEPTFVPTDEGLSTVRGYDPLFYQGSLQESPSTPWTMSRAPRTPIRGRDLTLFSSRSTWGDSSRVSPSTPLSSSQSVRVYSSPGPFDQLHPRESPFDPFTTPSRGIKFGAPVTTPRNLLWPSRSGGQIRTPIRAGRPSGSGLQFGAFDDSGGPAISPYRNIYSYDDTPVRRSKPREDTKGLVSRRLWDSSSPAQFGAALPQESLARMNEDRLLPRSLEQLGNRTVPQSVGSDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9A4</accession>
    <name>A0A401G9A4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0116410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609663.1">
        <property type="nucleotide sequence ID" value="XM_027753862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9A4"/>
    <dbReference type="FunCoup" id="A0A401G9A4">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9A4"/>
    <dbReference type="GeneID" id="38775667"/>
    <dbReference type="InParanoid" id="A0A401G9A4"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="356"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="420" mass="47641" checksum="7BE0F5B156E4066C" modified="2019-05-08" version="1">MSDHFPISQVDPTAPTPQNTPLTHAPIAAGLSRPTVPDISEDQEAEEEEASPTASAMQHAMLGMVQGKLAGLVGKSSGYIESLPNDVKRNIEALKGVQVKQIELQNKYKRECLELEKKYLELQVPLYDRRLAIITGASQPTAEEIDTGEQESLKDDPDHTLLPKDVAPSTSGIPEFWLTALRNHVGLSDIITDRDAAALKHLVDIRLSYLPASDPKPGFKLLFIFRPNEFFENEILEKTYLYQEEVGYSGDFMYDRAIGTEIKWKEDKDLTKEFEIKKQRNKNTNRTRLIRKARPADSFFNFFSPPVPPDDDTELEDEELNELEEKLEVDYQIGEDIKEKVIPRAVDFFTGKALEYEDIDDDDDFEDIEDDEEDDDDDDRFEEDEDSDEDDLPGRRRAPPKGRGAGATTTNVNPEECKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9K7</accession>
    <name>A0A401G9K7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609758.1">
        <property type="nucleotide sequence ID" value="XM_027753957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9K7"/>
    <dbReference type="GeneID" id="38775762"/>
    <dbReference type="InParanoid" id="A0A401G9K7"/>
    <dbReference type="OrthoDB" id="2788229at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="51132" checksum="E79D83FB4C351446" modified="2019-05-08" version="1">MATPPSMDDSTNGHPLFPPEMQDHILDHLWSDRSALKACSLTCRAWVPTVRHHLFHSISLRNIDIPSLLHVLNESIGLVHHVHKLSMRGTGQRMSLLDTGMLRLLERLGALGCVTVQWWRTDVGHSWQGEGNEPPLQAIPPRLRDAGPYFSVTRLNFMADCEFDRIEFDTFLLAFPRLSTLNMSNLSLFPNNTPQPRIPASIRPLVSEVSWAHNGGRFSPFGSELPPLGWHMNRGPLDLSRLSTLKVQLWGGVVWSMLRDLMHTCGGALRHLVLSLDDDIARFECKPGSIDLSRNVNLEILHIKDILLNCCMPLRCVCAVLCQLTYPLPDDGNGEQRHSHAHLRNVVIDLCNPYAFTTSTIPEDLDWDTLDGHLARILQYSAAAVVTLRVPAPLFEPHTSILAILRSLPEATKVGRRDRAGKHKGRVRIIPVYMHRYSSGPWEVGTDEAPEVWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA11</accession>
    <name>A0A401GA11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec14 cytosolic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0202110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609927.1">
        <property type="nucleotide sequence ID" value="XM_027754126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA11"/>
    <dbReference type="FunCoup" id="A0A401GA11">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA11"/>
    <dbReference type="GeneID" id="38775931"/>
    <dbReference type="InParanoid" id="A0A401GA11"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="103"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="289" mass="33151" checksum="28CBA26F078BACEC" modified="2019-05-08" version="1">MEFVQQASASPMPDGVTDPDYRPLPGRLGNLTVGQQHILDKFRKELQDEGVFVPERMNDAMLLRFLRARKFDLAKAKAMIIACEEWRKDFGVDEIYSNFDFPEIAEVDKYYPQYYHKMDKEGRPVYVERLGLLDMKALYAITTPERQLQRLVYEYEKMLKERLPACSKAIGHPVETSCTILDLQNVSLSNYYRVKDYLMSAASIGQDRYPETMGKFYIINAPWAFSTVWTFIKPWLDEVTVNKISIIGAAYQDKLLAQIPAENLPREFGGMCECAGGCSLSDAGPWHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA25</accession>
    <name>A0A401GA25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0202150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609931.1">
        <property type="nucleotide sequence ID" value="XM_027754130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA25"/>
    <dbReference type="STRING" id="139825.A0A401GA25"/>
    <dbReference type="GeneID" id="38775935"/>
    <dbReference type="InParanoid" id="A0A401GA25"/>
    <dbReference type="OrthoDB" id="2793366at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="618" mass="70927" checksum="230FFAFB32258C2A" modified="2019-05-08" version="1">MPTQASPLPQCFEESEEKKRQNDKKRYQCHFCAPHAGEDRQWIERRSISQHMKSQSHAQNADLYQLREQEAAAFQRRLADEEMALRGEATPMEPRLHEVLLPSIQPTLSRVPGPVEVQMWDEFELNQTNFDCGTDTTFGERQWLEKAIENLALWAADEVEEQAVDEELEVTMQWKQALREDEELAEIMEQAACTGLENHAEDNAEYSFAEREDDILADWFPYPNKMMMLLDTLDNLPRIAVSDSLMRVFLWILRETGAHNVPSLDRLRKLQKKLHQECGIPTKLYQSPKKNVFYYNDPRSIIVKDWSTPSVRKEIRHYPVIPIGPISEIWHAQKWHKELDVSILSPMYDAGDGRHYYVQELAQLKNGGLVIPVRWLEMEKTREVYADAHHVEIEATGNMIVNSAQTILIKGTDLQVNFLDLQETGMIPHLQDKARNECKFEMPNSLRAMADGDPLYSSFVDYWSDDVSGNRSKAYNKHWNCCITHRNLPRRLLQQECHIHLISTSQYATAPKQFKAFKEVAESTHRDPVPVRDAETGDNITFQIFVNTGPGDNPSQIGGTDKEKESNTGYDALFQTGEACSSTETLREVQRQLDAACTGVAAHVEKMQTNTGIHTVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB15</accession>
    <name>A0A401GB15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0205680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610283.1">
        <property type="nucleotide sequence ID" value="XM_027754482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB15"/>
    <dbReference type="STRING" id="139825.A0A401GB15"/>
    <dbReference type="GeneID" id="38776287"/>
    <dbReference type="InParanoid" id="A0A401GB15"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="522" mass="57906" checksum="5AF3A61C189ADFDA" modified="2019-05-08" version="1">MAKSDKMGETEHLEDPIQAVECKVEVVVPLHSELAAVLAKEKPQPWSRSMIRLYMVLAVAYLCSTTNGFDANTFGGASAMTSFQNYFSLHGGSRQGLFAASYVIGNMVGSLGAGQVSDMWGRRWGMAVGSFICLVGSVVQTAAQNGNYLIGGRVVLGLGAVIAQTAGPAYVVELAHPAYRGILTGLYQACFFSGTILSTWIEFGLSYVAGAPQYQWRVPMALQALPSVLVLMFWWFIPETPRWYVSQGKDEKAREILAKYHGGGNLDSEIVNLQMREMKEVIEVENGTDKRWWDIRGLLRTRSDRHRFFLVICIAFFGQWDLPPTSYYFPLMVEAAGVTNEHMVLLLNAIQTPIMMISALCGLQFLERWGRRPTLMLSSTGMSISVVIITVCTALTPKHSQAGPVGIAFLYIFLVVFSFVWTPMQSLYPVEVLAYNNRAKGLAVMNLFVNACGLFNTYLPPVAIGAVGWRFYIFYAAWDALGIVVIYLTFVETKGRNLEEIDHIFDSPHPVRTSLAKEVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBP9</accession>
    <name>A0A401GBP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0208000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610513.1">
        <property type="nucleotide sequence ID" value="XM_027754712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBP9"/>
    <dbReference type="GeneID" id="38776517"/>
    <dbReference type="InParanoid" id="A0A401GBP9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="250" mass="27034" checksum="D38144A6D2E1BC68" modified="2019-05-08" version="1">MTCDHVKCDVATPTAVPALPASPSLVSEKLAKPEHPRHIKSDAPHLDRKNRPQKSVGESVGVKEAEERRREERRPEKKVWEWTRSDREQERMPCKHDDARGTPAPSPPTAPPPRTCLTEHPTTPTALTRSHATPPHRGARTPTAPVTQDMDNVPATSPAPGARDHNSTALMHDTNDAHTTSPVRGAQARDSLTPMRLAVRATDHPTAQVVPSAPMHRGCATEPTATAVQDADVATDTPPVLRTRHAGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBX1</accession>
    <name>A0A401GBX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0208470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610560.1">
        <property type="nucleotide sequence ID" value="XM_027754759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBX1"/>
    <dbReference type="GeneID" id="38776564"/>
    <dbReference type="InParanoid" id="A0A401GBX1"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="206" mass="22703" checksum="81D06E4D0FEB0FAD" modified="2019-05-08" version="1">MSYPTKRLATNDAVSAQCASDEQPRNGIDADLAMRLRNMASRVRKTVTEGYTASSAPVSPNISSSKARLPFTQSIPFLSARDTYRDVYLSRADAPSPCPNKRKHTILEEAEEELSDEDIDMVNDMDDDVWTGDASHSVPHSSMLNVRPMKPLRPARLRLTGTRSLPVGIFRFTDDANGESSTMPTSQYVEEDWSNHLAPSSGPALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBY0</accession>
    <name>A0A401GBY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase epsilon subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0208840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in DNA repair and in chromosomal DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610597.1">
        <property type="nucleotide sequence ID" value="XM_027754796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBY0"/>
    <dbReference type="FunCoup" id="A0A401GBY0">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBY0"/>
    <dbReference type="GeneID" id="38776601"/>
    <dbReference type="InParanoid" id="A0A401GBY0"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000799">
        <property type="entry name" value="DNA_pol_eps_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="292"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="541" mass="61811" checksum="F2EF876367A26552" modified="2019-05-08" version="1">MSDTRQRTIIKVFRKYGLSLGPEALEFVEELLYRHEIPDEDVEFSIEWIAKEYNKQDDAQMKVSLEVLQRVYEAFQSSGDSQDQTDHELVDPESHLAFVDAFDMPLWHWSPERNAFERTTGPLTMSGSADSRTMAMRNRLNVIRQAVLRNEHFSPSTLPSRDREHLLTLRSTKQLLGRAGDRFLLFGMLSHSKEGKLCLEDQDGAVELDFSQLDQPSEGLFTEGCFALVEGDYTEDATFVVIAIGHPPCERRDTARSIYGHIDFLGKGSTTLLEDEQLAARVCMELPDLRFFVLSDVWLDHPETLFGLRKLLDNCIENSFIPKVVILCGNFSSRGIPQGNSREVRRFQDNFDSLAELISSYPSITRTTHFVFVPGPLDVTVNSVLPRMPLLSAFVSRLKSRIPKVHFATNPCRIKFFEQEIVIFREDLMSKMLRNLVGVKPDVRNDDLKRYLVQTILDQSHLIPLTNTIQPVLSDFDHALRLYPLPTAVILADKYDRYQMSYEHCHVFNPGSFVGSSFTFSAYTPSLQQSEECILSMDGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBZ2</accession>
    <name>A0A401GBZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Probable D-xylulose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0208800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610593.1">
        <property type="nucleotide sequence ID" value="XM_027754792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBZ2"/>
    <dbReference type="FunCoup" id="A0A401GBZ2">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBZ2"/>
    <dbReference type="GeneID" id="38776597"/>
    <dbReference type="InParanoid" id="A0A401GBZ2"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="86"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="451" mass="48316" checksum="E6F79E9120F852AB" modified="2019-05-08" version="1">MAGTSGRRRTLEPRPSAQCESIDGVLLLHLIPATKLPRESRPRHLSVGGPVSHPSSKVPLLAILPNLLPLSTLLSTMSTNPSFVLRAVEDVVYEERPIPDILDDEVLVEVKKTGICGSDVHYLVAGRIGDFIVKDPMVLGHESSGLISKVGKNVHTLQPGDRVAMEPGATCRVCEDCKRGRYELCPDIIFAATPPYDGTLARYYRIPADLCYKLPAQLSLEDGAMMEPLSVAVHAVANIAGLKTNQSVVVFGAGPVGLLCLAVARALGASRIISVDIVPSRLEFAKQYAATETYLPPKPEPNESKLAYSERNARTMKEKLGIEERGPKSIDLVVDASGAEVSIQTGIIVARRGGTYVQVGMGSAEITIPITTLLVKELNFKGSFRYGPGDYPLALALVSQGKIDLKPLVTHRYPFTAAIEAFETTKAGKSADGKGVIKAIISGPDVSPNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC54</accession>
    <name>A0A401GC54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuole protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0209430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610655.1">
        <property type="nucleotide sequence ID" value="XM_027754854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC54"/>
    <dbReference type="STRING" id="139825.A0A401GC54"/>
    <dbReference type="GeneID" id="38776659"/>
    <dbReference type="InParanoid" id="A0A401GC54"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56380" checksum="5A974E6A18A6C689" modified="2019-05-08" version="1">MCGGSTWKREVVPDHKFDFVDTREFTDHGIGMRFKYLFLYISVFISFLVYVSDIFTAVTMLTTKSWSNEIYNSCPPDQSDGCVYIPFSIGKWLFFGCIIFSFLLLAYEARKAKKIIASRDISYAFTNVMAHNYYSLRSYDHFCFFDHISNSTKKQDDFAFFVFFTFKGWKRIILAEGPRQSINALTLYAFYLTRVHDGSWYDISKYFAGNDILATALTISTGFTVLVFALSLLMLIIAGICYIPLLCYIQGNLKEYCCHKVDKRIAEIIKRRNKQRLAKAAALAKKEAAGDYSHLKNKKGELVVKPLPQPTLPNVSLDDDDDASSMRTRGPPPSTVSPSDYYYAGQKGPSEYVEYAADNDPMDYPPMPGYNQPYAHHPDMYHQYNPSTGTFQDDQAIYDDEYASTAHLTSSAAPFGKTDDGAHMMHNPYSTYTTNQHDPHQGNGTPVPEYTQYQAYPQHPQGHVPAGGAAYETHGGALYNDAYHHETYEYDAGQAHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCP3</accession>
    <name>A0A401GCP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0211320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610843.1">
        <property type="nucleotide sequence ID" value="XM_027755042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCP3"/>
    <dbReference type="GeneID" id="38776847"/>
    <dbReference type="InParanoid" id="A0A401GCP3"/>
    <dbReference type="OrthoDB" id="3251949at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="83" mass="9793" checksum="8E13A93FC5899C8F" modified="2019-05-08" version="1">MPRSHASCHLSVVREFTLRPCVRQGVKFWLRSSEDSILLRFYVGTLVFSSILQTALETYKVWLDVIIRKHWVYGLLRIDRPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDD9</accession>
    <name>A0A401GDD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0213540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611064.1">
        <property type="nucleotide sequence ID" value="XM_027755263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDD9"/>
    <dbReference type="GeneID" id="38777068"/>
    <dbReference type="InParanoid" id="A0A401GDD9"/>
    <dbReference type="OrthoDB" id="2867883at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19864" checksum="63AA0D97C205D665" modified="2019-05-08" version="1">MGWRSNTSSAREPYTWPSSPENWFSGVCDHSKVLLQGHQRTVSVDLRLHDAWQYGESRSPVIPRLHCELQTIHHLDQERIALMKNAIGISKDICVARELYLEQLRARLGRSADIRRSQEGRTQLGGVVPVALPDSRTLTREVVEISVKHVFHVTKREVQKWAADVFTNLLPGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEE3</accession>
    <name>A0A401GEE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611462.1">
        <property type="nucleotide sequence ID" value="XM_027755661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEE3"/>
    <dbReference type="GeneID" id="38777466"/>
    <dbReference type="InParanoid" id="A0A401GEE3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="401" mass="44620" checksum="6D0B54A8B275BF8B" modified="2019-05-08" version="1">MARWQISLDMMDEERRQLVDFSECKHSLRSQLAFLAKSDRYRSRAKELYNTVHERYGPLIAATFRERLVSSSSEYLSATPVITGIVITMSAETEFFTDPLSYIDVPRSQGHSRHISNGSTSTLLSDSEYSRDLDTSSEELDEAYNNGSRLTNSHNKNVRDDTDTALSARRQGTINSGGPNCDEPIRDRTTTTNSRPSGDGTIPQINAQCGQYSSSQHSRAQPAIDDMIRRDASISPLEVLYSTQPSMDIRLPSSLRSHLTSGTAFEEHSCHLATNSASGSRYRSAIDHQQKMTYFRSIGSVGRAPTSLPIDDSDSSLGHILPDEQRAIALASCDWDLVVNETETKKNRPSESGNSLKCTISANRLEAQKRKDSYRVWSEDYMGKTTTLGQLPNPSKKANVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEN7</accession>
    <name>A0A401GEN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0303720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611567.1">
        <property type="nucleotide sequence ID" value="XM_027755766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEN7"/>
    <dbReference type="STRING" id="139825.A0A401GEN7"/>
    <dbReference type="GeneID" id="38777571"/>
    <dbReference type="InParanoid" id="A0A401GEN7"/>
    <dbReference type="OrthoDB" id="2688364at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="544" mass="61107" checksum="39374CE6728C1228" modified="2019-05-08" version="1">MSMTLATVSCPALLTLRYQSSLADFDTYLSCTFTRTSIYSLPDDLLLLIISYVELKDILALRKTSKRFYSMTKLRWVWYDAMKRHVIAKGLPVPAADVDLRVFSAEHLEARAVHAAKFHDNWCSPQPKPRHSIEFHAERCLPDELPQDLKTTVKHVFFLPGRNGEFLVTVVGRVITCWEVPLDGSGAYRVAEWVSSSRVEQAVVNEDPKNEAVLTFVSEVSTGPGEVELTTLSLDKFHGHFTVRNRIRGHRNSVLPLHVMDGDYVIFGDPLVVWFRTSPLDVQIIPEREVYPLVGDESNKVLVVKPINRYMLIVREREYQLVYSPIWNGKRTVYGPAKDISACVLTQFPAKDAVIIARSSAAASGDDEVEWPNELVTILIRCSEDGLDTIQQFDLLPAPQSKTVQTEPSEPKEVFRVPCVFPTGSTRVLVVPPSCCKLNAGSSGKGYWIQTWNVTSRHSEYPARCLMGFHLSSEGEGKDDAIKLQYGQPGSDLNLCQGTLYSRRCDMSEIIWKKYMIVSTALEDTVGRLAIGDRTGKVEVVDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF65</accession>
    <name>A0A401GF65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611731.1">
        <property type="nucleotide sequence ID" value="XM_027755930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF65"/>
    <dbReference type="GeneID" id="38777735"/>
    <dbReference type="InParanoid" id="A0A401GF65"/>
    <dbReference type="OrthoDB" id="2959034at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="450" mass="49029" checksum="4E95A513C8C3D43C" modified="2019-05-08" version="1">MIVIKDPLPYIGEAELAAEAPPAYEDGDFDQWAAATSEAYAHLQETKAGPPTARPFGRILRTFASTPRTSPVSTPSSPSPSTPISPTLSSTLSSLQSKKPGARSSTWFARTFGSSSRTAKEVKESVTGLLREIVKQPETTASVLIIDSCAEACRTHNLSLPSILQEPSLEGRSTIYWAVIKHPLQPPSPHERDLISTLLDLAAPLTEATISEIRLACLQNSNQPLFQWLRQMPVFSPLNGKDEILLGSSTPRDEIAVENVPGDEGAFIVRFRVMLFQKRMRVSKQVKLEFIARGRMWSLKFLIVTDGDKRLSHRRERPGTWAVTLALVEHSPPTWIDSRLIIEEAPSTSPESASTSQSLVDVVRPFSPSKGGEARANSKPTISLRLKSGSSQLAPAGPNYPNDMIVASLGESLMANSLQYDGSSYIGSDESLQARLEARLGKPDAQCIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFX7</accession>
    <name>A0A401GFX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0308220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612010.1">
        <property type="nucleotide sequence ID" value="XM_027756209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFX7"/>
    <dbReference type="STRING" id="139825.A0A401GFX7"/>
    <dbReference type="GeneID" id="38778014"/>
    <dbReference type="InParanoid" id="A0A401GFX7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF20">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE81097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="273" mass="29814" checksum="1AE2774D87649E3A" modified="2019-05-08" version="1">MPPRQSPPPEISRRGEQRPTLPPIRQLFGTELSQSVPPPQARQPTSSPHIPFHRLTLQDEERRYASSSPSAGQRSSSLISSHSHPSHHGHPGSSSSGGHLSNPSDPLYRSQAYDAPQQYPPHGLVHPSAYPPQALDRSAMASGTYPYSTSLPAMQQQSIPLPGPSAASLGDFSAERLSKYECGYCGKGFTRPSSLKIHLNTHTGEKPFMCPYPGCGRSFSVQSNMRRHARVHSRTDAPQQEQGEESMEESDEQTSSDREETPPADSSKGKDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFY4</accession>
    <name>A0A401GFY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0307360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611926.1">
        <property type="nucleotide sequence ID" value="XM_027756125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFY4"/>
    <dbReference type="STRING" id="139825.A0A401GFY4"/>
    <dbReference type="GeneID" id="38777930"/>
    <dbReference type="InParanoid" id="A0A401GFY4"/>
    <dbReference type="OrthoDB" id="2804767at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="934"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1055" mass="115508" checksum="3CA2544E7F7E8A85" modified="2019-05-08" version="1">MLVGSSQHGAQSEHSSPLSGFKFTIIGQPPALLQRLGPAQEDSQYSSPSPPSLTSELPSAQEAPRTRPSLLEALSNSGDIILNAEDSSNSLLVPVFPENASTEPPHQPSLVPSPHNTVSQISMTSIRADHTLAGSPRTPTVPATNDDTRTNDYVPIGKGDTTAVLQEHTHLSRPSPSPDLFTFLSLLTQEQADWDEIRNLKEKYQDEYKELLLRKDETQRAVQRELDQANKLFALAESALEKMELLRLKQDQRLSSEKHKAEALAAEAAKLLEQRDQAELQKAMDERRRNEAERQMEEKRQQETAAAEAEAAAEQDRLRKLEEQRASEEANKRRCEEEGRLKAEEDGRRKTKEREAVFVRAQEEKRLQEQEAEEREKLRQQELRKAKVMEQKKAAAADNAARSRAAQLKAKLEKEKSEANSQLSAPPPLPPSTTSISTPPGKERHVATAPTNASSAKAPPYQSSGIVPAAPPPPSLPTMQASLPARPAIDAFGAEPTKSQRSRGAKQPVRVTNPPTALADPSGVPGRSLLTQKGVRLHSTSSRVALPHPAIQGEVLPSSAAETSQRVHTVKIEQLTSDIPRSTGVSNSDALSHKPPSDHEELLDSEDLHSQLKSRPISSLPSRNGASTSSASQLQSNVSSRLLTAKGTHSDPFQASGTGSAPPSDRNPSIAGSKVPEADGVACQSAAPQIPSSELRALAVNGGSSIMPGKLPSPGHSHMMDGGWSSYYHDDPWVNTPRAERMSPIEDRVPEKGDRSLQTDGVLGRPAGDHWSPSPDRGRDLQPRHRGDFVSPQDRHPRGPTIRNHNPAPGPTRKRRRENDDPWLSNEQPPLHRRRPAEMAQETRRIPGAQTRPVEPRSPSPLPPRMYDPRLRSPTTYSARDAVYVGDPAYPDYPSDLLPRNDNWFFPSAYDANGSQPYDYYASQDERRLVSGPAASDSVAQSSSVQDRPGNHSSVAESEYLHDQGRSSLLRRMKAPERRQAGGSTRNDNDDWADHLSYSPPLRASQRGRGATNRSRGNSTASKGSGRQQRPTLQDRLSTNSKQNGKTSDLGARLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG40</accession>
    <name>A0A401GG40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0308740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612061.1">
        <property type="nucleotide sequence ID" value="XM_027756260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG40"/>
    <dbReference type="STRING" id="139825.A0A401GG40"/>
    <dbReference type="GeneID" id="38778065"/>
    <dbReference type="InParanoid" id="A0A401GG40"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="480"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="398"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE81148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="596" mass="64113" checksum="5389F7EBC58D4BF8" modified="2019-05-08" version="1">MFTLFPGSRNALKPGCHTTVSPSPTPVTMATSAAILTLWLRLCVLQFLCGLCARVRAYIPAIPTNSTALVGSGGNTSSHLDLQWYPMASYSEQVSYQLVGAGSSGVSKGALVHFSETNLTTNDFTTTPWIALVSCDGNATNASQEADIFTLANQRGAVSALLYSLQSQSCTINPDYADPANFNQIMDIFTMESLATANAIEDQFNAINNTKYYYFNSTLLNESFSAINDTIATGDVGSEGYVFATLIAYNATDPAPSDGQGQKSFSSSSSGGGANTSLAMIILYAITGCVSALFCVVIASGAVRAIRHPERYGPRAGDAPGFGAAQSRARGLTRAILDTFPVVKFGSSGHEENVRPKDVESSPVDQPTAEEAEDLAHDAMPGEFALQAWEVVDGEWRLSSQGRKSTDEEGESSVHGHSGGTMEDAEGEEDVTTPGASASASDHLTPLPRPRPRLLTREGASTSGRAEKEVVPDAIGRETCPICIVDFEDGDDLRVLPCEGHHRFHRECVDQWLLELSSSCPICRQDFHALETMMARDDEHLELPHMFGSARPLSTAAARFSRYLRIARRRQVRERDDGHGYDVTDPPMPLASEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG86</accession>
    <name>A0A401GG86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0309060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612092.1">
        <property type="nucleotide sequence ID" value="XM_027756291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG86"/>
    <dbReference type="STRING" id="139825.A0A401GG86"/>
    <dbReference type="GeneID" id="38778096"/>
    <dbReference type="InParanoid" id="A0A401GG86"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="523" mass="57728" checksum="1A2AE28B49474740" modified="2019-05-08" version="1">MSWNTNKTSNSPDHRYQPVYQPGPTPNYAETSYAPPPQPPYDQTYGGGGYGDQKSPFEGDRFKPRPRINDPIFLIFFILQFAGFTVLSAIVIKQWIKNRGLGGGIGSGDTGNAVTLNYHTVILLLLVTAAGLVLATFYLALTRYFTRMIMHITLILSILLNIGICIYYWITKYYSGAIIFTIIAVLSILSYFGFRSRIPMSALLLQVVMDVSKHHWSTYVVAYVSLILQAALSVWYTFTVIGTYAKWTPGSPSCSSSCSSSKVAGLIFYETFSYLWTSQVFANVALATLAGGPYGAWYYFGPREQGLMPKHPALSAFGRASTLSLGSIAFGSLIVTLLDLLRLILNAVRNNANSQGHPVEVILALCAECFIGCIEWAVRYFNRYAYIEIALYGKPYIQAAKDTWRLFKDRGIDALVNDSLVGMTLTWGAYAIGLLCSLFGYLYLRYTHPSYNADGQYTAPVMLFAFLIGLQLMLTLGAAIEAGVSTIFVGLAEDPQVLAMRAPELFGFIAAKYPQVTQGVPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGI5</accession>
    <name>A0A401GGI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0310240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612210.1">
        <property type="nucleotide sequence ID" value="XM_027756409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGI5"/>
    <dbReference type="STRING" id="139825.A0A401GGI5"/>
    <dbReference type="GeneID" id="38778214"/>
    <dbReference type="InParanoid" id="A0A401GGI5"/>
    <dbReference type="OrthoDB" id="2796692at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48087" checksum="EFCEE58A0E18C9F3" modified="2019-05-08" version="1">MLPTPISSPHHIPSRNLSGQPWRPWSVPLDPLHTERKLCGLLNKVTKSNFDRISDAVVDWALTMERTEDMPSITRFASVMLTRGVSDRMRAKVYGELCQRIMDEVQSERVRCGKADPYLLDDPFRSAMQAAVQSESERILEEGDIQDLAALTHFITELLMHDVLDVEKAGDLFDMFFTETENGNEDYAVILYRSLSRLVHAPEIIDSLEIVERIERLLRQGSISLKVRYLMMAVLKRANDHEPQDSFESSHPRAEIYGIVSVGNVDNELRTRDPDDLQQMCDDAAKGFVLSKVLTSAEDVFGSLAAKDRHLFVASLVSVAVSSQAGDEADATLVASLFGLNSVQELCPVQDAFIPGFEGEISRLGTTVLDIPKAYRRVAIMMNSCGMSQSVVEDLVLRVARTRRGLIETLLSEFETVVTGHKRESYQGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGW2</accession>
    <name>A0A401GGW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0311310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612315.1">
        <property type="nucleotide sequence ID" value="XM_027756514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGW2"/>
    <dbReference type="GeneID" id="38778319"/>
    <dbReference type="InParanoid" id="A0A401GGW2"/>
    <dbReference type="OrthoDB" id="2756548at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="505" mass="55794" checksum="9EA3D6B9AD531A3C" modified="2019-05-08" version="1">MAPWYPKSPTSQSVYHDYPDVQSRSWHFDLSAVRSTLGGVTPPPSPIPERPRLNHPPMQQNKIRKYSVRRYREVIPGVLEDGTITARHPFVAEYLRALTSRALCSRLQAKRSQGSSVPPARLADVGPLLGLDLDDRQSRVIFALAALAILYHPRQRIHECFWGRRTRAYTDRIICSVRYIPRPLIYDPEMYLGLHSHLYMLNCMALTCHQSSQHATVAEMEPRTLRKRHASARISANGVLKANPAEGHEHELMHVEPYDKRITSGKEERMQTRSRARARTTVSPTPARAPSPNIPSTPAPDTPAAPARASILKWKQDAEDMVVDHPGSVTHESNRLVHPRLAPSASQAPRRSTRQAARRVVSNPATATAVADATAKKPPRARSASADSDSGSSSSSTTVCLSGSEATVVDVVIPSGKSNKMTEEDDAEDVPVTVQPRRQTAKRARGKEQEREPTRTKRKRRSPADECDAEKTAPTPRKRACKAGSKPPILGAAAPKTKLGVQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGZ4</accession>
    <name>A0A401GGZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0311200</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612304.1">
        <property type="nucleotide sequence ID" value="XM_027756503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGZ4"/>
    <dbReference type="FunCoup" id="A0A401GGZ4">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGZ4"/>
    <dbReference type="GeneID" id="38778308"/>
    <dbReference type="InParanoid" id="A0A401GGZ4"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE81391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="362" mass="39579" checksum="1D455D05CD50FC93" modified="2019-05-08" version="1">MTRVARLIFPKRLDRKTPSHFSPSPLPAVTEISSMDISSVLQGGYQHPLSRSWQARRHLTKGMFMYPIFITDEPDASVDIPSLPGQRRWGVNKLEEFLGPLVQKGLKSVILFGVPLKCTKDDRGTPADDPEGPVIQAIRKLRTLFPALYIACDVCLCEYTSHGHCGVFRVDGSIDPEPSAGRIAEVALAYARAGAHCVAPSDMMDGRVKAIKRALIDGGYGNQCTLMSYAAKFASSLYGPFRDAAGSAPAFGDRKCYQLPPQAKGLARRAILRDVGEGADIIMVKPAMPYLDIIQDAAQLAPNHPLACYQVSGEYAMIVAGARAGVYDLRTMAYESVESFIRAGCGLILTYFTPQFLDWLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHF9</accession>
    <name>A0A401GHF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0312840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612468.1">
        <property type="nucleotide sequence ID" value="XM_027756667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHF9"/>
    <dbReference type="STRING" id="139825.A0A401GHF9"/>
    <dbReference type="GeneID" id="38778472"/>
    <dbReference type="InParanoid" id="A0A401GHF9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="326" mass="37857" checksum="B8811CA1435AD9CD" modified="2019-05-08" version="1">MDEGRHHVSQKELGFRKTEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKITFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETAHTLLRNIKQGTRTADDYIAEFRSIESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASQFDNQWRSAQIFKRGATMTMRGKGRSVHRPYYSASAKDPNAMDVDHVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKETSKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHK8</accession>
    <name>A0A401GHK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0313320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612516.1">
        <property type="nucleotide sequence ID" value="XM_027756715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHK8"/>
    <dbReference type="GeneID" id="38778520"/>
    <dbReference type="InParanoid" id="A0A401GHK8"/>
    <dbReference type="OrthoDB" id="2790277at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="241" mass="27340" checksum="AE24DD91A6EF3C9E" modified="2019-05-08" version="1">MMDVMEYPIEELSAHPALDYIPEQIHTYDFRRSKVELVGSWYLSYDVPCIVSNHVDRDGTKLCSVLRTHPVVARSFATFPPVQCMSFEEFIGVELPDLFNPSGITVQDVADTLHAKLEEGLTVAAVAALLASELYSETCEMPNWCITEAFLRFTTLGGIFSVFAVQKVIVREDMEGHRLFYIWIEVRKDNFADTDIDGDPITSMFHWRRRESPPGLCSVCLDLDMNIMTPAVVLACYYIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHR9</accession>
    <name>A0A401GHR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0400980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612640.1">
        <property type="nucleotide sequence ID" value="XM_027756839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHR9"/>
    <dbReference type="GeneID" id="38778644"/>
    <dbReference type="InParanoid" id="A0A401GHR9"/>
    <dbReference type="OrthoDB" id="2523549at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="150" mass="16776" checksum="46079BADCA3A27C0" modified="2019-05-08" version="1">MLVDKMNGREDAVNAFILAWTVVMASKGIPRKVLPPFFNVRACCATRSTISPPPPNITDYDISLAAGQDDVESLIPFAVQFSVHVPHRSTAESARIAMGRYQTGKSGFVVLTERLLRIRFYLDDQHRAPLLFTMSTYFRSTAAEASPRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHV5</accession>
    <name>A0A401GHV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0401090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612651.1">
        <property type="nucleotide sequence ID" value="XM_027756850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHV5"/>
    <dbReference type="FunCoup" id="A0A401GHV5">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHV5"/>
    <dbReference type="GeneID" id="38778655"/>
    <dbReference type="InParanoid" id="A0A401GHV5"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="348" mass="38817" checksum="B77E745EF41AE8B4" modified="2019-05-08" version="1">MKKKVLLMGASGSGKTSMRSLIFSNNPASLTARLGATIDVEQNHVRFLGDLILNLWDCGGQDAFMDSYLSTQQSTIFQHVGVMIYVFEVQSRNMRKDLEYYRDCLAALRRYSPDAAVFLLVHKMDLVNEPRGQTLDRKTAELQQASDGMGVTVFGTSIYDESLYKAWSRIVHTLIPNVAVLSKHLTTLAHACNATEVILFERTTFLVIATSSPPPSPASIPLPVTPLFSTPSSMHSNGLLTPTSTSHTRSNARYTPDDSDPHKLAPTRYERTSELIKAFKHACSRVREDFRSLEMELAEFTAVLDELTKNTYVLIVVHDPTIETAALKMNIRLARKKFEELQGDSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI34</accession>
    <name>A0A401GI34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Golgi apyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0402380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612777.1">
        <property type="nucleotide sequence ID" value="XM_027756976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI34"/>
    <dbReference type="FunCoup" id="A0A401GI34">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI34"/>
    <dbReference type="GeneID" id="38778781"/>
    <dbReference type="InParanoid" id="A0A401GI34"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="194"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="765" mass="83172" checksum="7E8267631ADED847" modified="2019-05-08" version="1">MPPPTSVDSWLTARRFGIVIDAGSSGSRLQIYSWKDARAMQGAGIALDTLPKVEKGTLDSEEWSMKVEPGISSFADNLEGVSGYLAPLLEHARTVIPPSLEPETPLFLLATAGMRLLNPTQQAEVLQATCHFLRFHSNFRIDDMSPAGPCGSSVRVITGEAEGLFGWIAVNYLMDGFSASGSELPTYGFLDMGGASTQIAFEPSKEAQENAQNLADVRLRLLNGEEIIHKVFVTTWLGYGTNLARERYVGQTLSEYDSNRTSSSTQDRIILDPCLPRDLQLTESPAHLDSSNAPSKIQPTLVGTGSFEQCLERTLPLLNKEAPCPDENCLFDGVYVPPIDFSASNFIGVSEYWYSSEHIFGLGGAYDVVQFERAASEFCARNWDDIVRHHESSQQQGKLGGAGEIQVHGEFAGAGVWGNKVNISRLQMQCFKAAWIVNVLHEGIGLPRIIDAGGNSSTNGDKVAEQAATKGLGRPAFQSMDTVGDIAISWTLGKMVLEASKEVTPFSASVPPLIDPLSNSPSVVNSPSKSHLPSFLDFEAIEDRISHRLPISLTRQSLGFSPVATLFYLTVIAVCLAVMYRLRHRVRSAVRRIIYRKDRGYTLEGYAMEEGRALNGGSQLRMSRSSSLLRISSQILQPLKTLSSSLGSRNHHPPSIGITVTSRHPTRSGQYSPSRVSPLRSLSYPPQKPPLLSPIDAPNGTATAFVPGSPRLQDGSIVSNGSLASLTSRSRNSSQVNLAVLTPRQTISRASSGAYRLSDRFWNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI43</accession>
    <name>A0A401GI43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0401660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612706.1">
        <property type="nucleotide sequence ID" value="XM_027756905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI43"/>
    <dbReference type="FunCoup" id="A0A401GI43">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI43"/>
    <dbReference type="GeneID" id="38778710"/>
    <dbReference type="InParanoid" id="A0A401GI43"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33358" checksum="45043A0CD57EF500" modified="2019-05-08" version="1">MSTSDSRIWFITGSSQGLGRALLEEVLASGERAVATLRKPTVLAPLVEKYASSQLLVVPLDVTDEAQIVAAFEATKKHFGRLDVVVNNAGYGLEGEIEDTPEAEARKQIEVLFWGPVRITKEAIKFLRDVNPPGYGGRVLNISSVGGYSSNPTLAFYSAGKFALEAFTEAFTKEMLPEWNIKGLIIEPGGFETEWGGSSMIHVPIHPRYQGPTSPGLAFRKMREASHQYGGGGIGDPNKGGKVLMQIASMPNPPLRIQLGTDSLMLVRNKALKTVRDGETFEEISHSTNKDGIDKDQILGMIKEANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIA8</accession>
    <name>A0A401GIA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPP4R2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0403000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612839.1">
        <property type="nucleotide sequence ID" value="XM_027757038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIA8"/>
    <dbReference type="STRING" id="139825.A0A401GIA8"/>
    <dbReference type="GeneID" id="38778843"/>
    <dbReference type="InParanoid" id="A0A401GIA8"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33525" checksum="FA2FA28C4EB21958" modified="2019-05-08" version="1">MDTTSSQFEWMPEYDELLEQIANTDLVDVDWARLRDIIKYKIEKNIALFLSGTLKSDDTTTSPHWPGSAKLPPFPPRARNEANPNEAPKKILTEKEAAAFRENIDSQLDENPPFTIQRLCELCLRPQKHYKYVGPYLRAVERSLLVTSTWDAFPITKEGRSGAGGVGYVSIHHGDLSIPSTPIFSPIPFLHEDARRSHSRSPPPSPLVLPASGMVGDASSGEGPEQRALGLVDEMDDPGPLHLSDHPHPLSSTTTISPQPLHSSLGERFVRAKTEEHESGGKTQKSGGGETSAGGSRPTGSAIPWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIB8</accession>
    <name>A0A401GIB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argonaute linker 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0402860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612825.1">
        <property type="nucleotide sequence ID" value="XM_027757024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIB8"/>
    <dbReference type="STRING" id="139825.A0A401GIB8"/>
    <dbReference type="GeneID" id="38778829"/>
    <dbReference type="InParanoid" id="A0A401GIB8"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Argonaute linker 1" evidence="1">
        <location>
            <begin position="96"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="17182" checksum="C48B577EA49C34A2" modified="2019-05-08" version="1">MQTDHAALFSSRIVYDGRANLFVAKDIPSADYPVHMGLNPSRGHFIVRLQKSAVINPRDIENLTRPGGSTPHTSSMAINLLQLIVRQDANLRHGFPPEGRSFFLSKSAIPLPGGLQAWRGYFQSVQPVVNRLLINVDTSTAAMYSSGPLLDLAMGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ02</accession>
    <name>A0A401GJ02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0405290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613062.1">
        <property type="nucleotide sequence ID" value="XM_027757261.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GJ02">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ02"/>
    <dbReference type="GeneID" id="38779066"/>
    <dbReference type="InParanoid" id="A0A401GJ02"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1371"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1630"/>
            <end position="1825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1825" mass="204777" checksum="1F0B87C90652DC70" modified="2019-05-08" version="1">MDWQVLELNIQQLILSDLAANIGESKDDSQNSDIQSTVALVAAKVETRLISEEVPVPENLREERVFMPNSRIQCNVGFAELAVNLPNSHVNETIPVLVDILRDVPYVDFDQCLAWEEWALPDQLVFAVVSALLRIASSHPARREVVMQALQNFVMNIVSKLNTGDSVDVLTQYAPSFHGLYRAIISMSFDWTTDEWSILSGHLNSLFTTDVVDRLNRLLVDVIPAKGYDPEEIHYIQTLVSRYVSRGRPLSGYFIQCCVIEAQWTILAQALVCHDAAYAAVYPATVEAAAANKAWQTLSRRAITESKMAEGTYRIMLQTTFGHATQCFTYLILQIEEMESDPSEDSYAWETMSESLKLAAVCSSALGELDKGLYSRLKLLLSPESQVCDNMVQEAALKSTAILVRNFPEVALDMASHLRRFVTSPLSIFEFEFVTGTRTPPPLVAAAKCLALCIDLAVGDDLVMSHMYSLLNYVAATSKDSYESSLTITSSLGEVADLATLHSVETGLRGLTEDEKRTVGISTISVATRLALEFRSEEVTRLTTSMLLQRLRTAEPTVEAAIAYNLVDLALIAPESSFVDIIRAFSSINRSANLDDPRFSNNMVLAAQTRLAQELHHRPELYEVYLVELLTLFADKAVAIQNVAISNHQAKMEDMIEQLGSLLLPIDALLSHSDMKLDPDTRSNIVTLFRNMWFLCVLFQFTAPGNKEQIAMDWQQPALARIAVKTPAIVLEEAHDTIVSDLEYNTVIRQEYVETVVAKHRALLTKHIPQRIGEVRYLLPGQIIFLLCMHDMESMRSAAGFPSSLIAYFVNNGLNKNVGLHTCMEAIAEKVIRGCIIDLNGQAAKQALPPTLSQELRGLLVCSTHRVEEARDISSKYLNRLITSFPSLMCDPALVIAVLEVLTLLRRASENQFVDEDNPVYLYRSDKADLTLQLPDNYAARDHMLSHLQRDANTWFELALSRAPMELYSTLQKYLAVNQVLSVTDSSELGASMAVHFGKAIGPIDRKLTSLSTLSAWKPDRAKVMASQVASKSYFKGEVTGFRFGTFVASQKDDFSSEYVPAQEIEALKSRMTEAMQDIREKKKTLTVQDLKRLLFRCAAALIFADKREYDLLHYLVALPFEAFTPSSITVGIEAWSWVIAEKPDDEIALMSEICSAWAGSIKHEKGMFSRSMNHGDPFLHAIEYSPTDKDVIDHGASNASCKVSPTGPDAAHSAHGLSIRSRSPLFQVDTHPLAREAIFSFLLFGFETLKSSHLDIYCEHALRLNLYRAAYSWFSVRPQWSYGANRVQIDADIKLLSEFLSYLQADSIRGYQTISSLSPAQSPSQNAAYMASLKNLNLPLRLLIENEISRLTVWANPINDPNRGSDYLTAIEKTMLDSSWISTVRRTWEIDPAIAVFLTERFNNSTIHSEVAKLVRSSTLDVLDVPEALSFLVGERLDRSVRRDLKYILLWAAVPSVLAISYFERRYSNEPLLLQYAHRVLEQHPVEVTFFFVPQIVQALRYDTLGYVARFIFETAKISQLFCHQIIWNMKANCYKDDAGEIEDPVKPILDQMTDSVVASLSGEAREFYDREFGFFREVTSISGKLKPFIKRTKPEKKAKIDEEMAKIRVEVGVYLPSNPDGVVVDIDKKSGRPLQSHAKAPFMATFKVRKTKAVIDADPDNLLEEQETENLREYEVWQQAIFKVGDDCRQDVLALQVIAMFKNVFHSVGLTLYLYPYRVTATAPGCGVIDVVPNATSRDEMGRAKVNDLLDFFIAKYGGEDTVEFQKARLNFIQSMAAYSVVCYILQVKDRHNGNIMIDGEGHIIHIDFGFLFDIDKHSVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ09</accession>
    <name>A0A401GJ09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0404930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613026.1">
        <property type="nucleotide sequence ID" value="XM_027757225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ09"/>
    <dbReference type="STRING" id="139825.A0A401GJ09"/>
    <dbReference type="GeneID" id="38779030"/>
    <dbReference type="InParanoid" id="A0A401GJ09"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="133"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="493" mass="54986" checksum="C79039F10BF98EF1" modified="2019-05-08" version="1">MSKHDQTDHATSTDYAPKSIGELKELLKHDIKVKVAGIDVDGVLRGKFMSKEKFISAASSDGFGFCSVIFGWDMHDAVYSRELLISNRANGYRDILASIDLSTYRRIPWENDVPFFLVSFLDPETKEPICADPRGALKKVVDRAEQKGWQCFAGCEYEYFQFKETPESLAKKNYVNLQPLTSGMHGYSLLRTQINNDYFHDLFDESWKFQVPLEGHHTETGPGVYETALAYTTALRMADNAILFKFLAKSIGIKRGVVPSFMAKPWGNLPGCSGHIHVSLRDQNGKSLFAVSESELQAGRADAANDDTKFLSQEGEWFLAGVLDGLPDIMPMLVPTINGYKRLVGGEAFWAPNAVTYGYDSRAASVRIISPPSVPPAATRLEVRVPGADMNPYFAISAIFALGLRGIEKKIKLTGPPVSQLTVEDKRSGKVKMLPQSLEAATEYMMRPESIAREEAVFGQDFVDHFGGTRQHEVKLWNEAVTNWEVERYLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ69</accession>
    <name>A0A401GJ69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0405920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613122.1">
        <property type="nucleotide sequence ID" value="XM_027757321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ69"/>
    <dbReference type="STRING" id="139825.A0A401GJ69"/>
    <dbReference type="GeneID" id="38779126"/>
    <dbReference type="InParanoid" id="A0A401GJ69"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="29947" checksum="239EA9E41BA7D049" modified="2019-05-08" version="1">MKYTAVTTPFGLYEWLVMPQGCRNAPSTHQHHMFSALRLLIGKICHIYLDDIIIWSQSLEEHIHKKTSLFLTELSFLGHVISQVGIQADPQKIEKILNWTVPCSVPQVRAFLGLVHYIAPFLSKLADFTHILNPLTTKDAELSFPPWSEEHQIAFDNIKALICSREVLTSIDHDNMGNNKIFVSCDASDFRTGALLSYGAEPNYPVHEKELLAIMRALKKWHIDLLGVPFTIYMDHRTLENFFHQKELSRRQAHWQKFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ83</accession>
    <name>A0A401GJ83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0406110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613141.1">
        <property type="nucleotide sequence ID" value="XM_027757340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ83"/>
    <dbReference type="GeneID" id="38779145"/>
    <dbReference type="InParanoid" id="A0A401GJ83"/>
    <dbReference type="OrthoDB" id="2526154at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="116" mass="12512" checksum="C9601A22DE575E8F" modified="2019-05-08" version="1">MPIPSPVLPAEKNSSVCKSSILKSWKSASGSLSAQLLHNGRAQHFSEAPLQDMLMKHRRSSLLDGIAFTRRGSIVSFSTLADIPASPALPEQFGYMQPLRLKAVAAGREGEERVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJM7</accession>
    <name>A0A401GJM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0407480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613277.1">
        <property type="nucleotide sequence ID" value="XM_027757476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJM7"/>
    <dbReference type="STRING" id="139825.A0A401GJM7"/>
    <dbReference type="GeneID" id="38779281"/>
    <dbReference type="InParanoid" id="A0A401GJM7"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="17769" checksum="89A043271F8D0902" modified="2019-05-08" version="1">MASNSKGWFNIESLGGTMPETQFFEGDSAFSFLGLTRTQRLYGFGGCVIAGFVLSLLGSILLFVGQLSTFAVLYAIGTVISLAGTGFLLGFMKQFQLMFKPVRVVATIVFIASIVLVFIGAYVIRSDVLCIIFVIIEYLAYLWYTLSYIPYARAAVLKVFGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJQ5</accession>
    <name>A0A401GJQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0407800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613309.1">
        <property type="nucleotide sequence ID" value="XM_027757508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJQ5"/>
    <dbReference type="STRING" id="139825.A0A401GJQ5"/>
    <dbReference type="GeneID" id="38779313"/>
    <dbReference type="InParanoid" id="A0A401GJQ5"/>
    <dbReference type="OrthoDB" id="5597783at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="81"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1028" mass="112185" checksum="E8D1BB95D0D568E4" modified="2019-05-08" version="1">MVSTAASPVQQQPSTQHQYGTRIRSNSIIRPSIRLRQSPDPPHPPRRIKPVPAPKSKLGLVTSPPPQPDFPPFPPPHVMLHSDDANSKIFMAIGRSFMSVDNRAMTIKDLAEMTMKYGLMCQNVSAAGQAITTYLRNHLQRCDVQQDHPLLLRHVLSGTAHDDDLVPALHSRVGGAHCTLSASDNRVTNFRRGTMVWYLSKAAGAPCPFARAGIQLSDYSENGRVGSIPNHGREKKRERDRVRRAEQCGQKRKRLLRACADKGSDSDSLGEEEKRPPKVKLTLRLRPSLVSTPGASTSAASALPSDPTHPSELMDLTVDSDSDDDSMSIDSETSEESSPGASVVLEPYPRRSLSIPSYTPSLDGSYIAPEEQTDHRRSPSVPYSVESASPPPDSEDEDADFHISMTSVRRSSSGYDLDEDEEDDLFYNGFYDVDAETTYESPGPRSPSVQFEDEAVVKQEPIDLDGHLAALDDLEITATGIEVVRIVEMAAAGLDEVGLPKEDLESCDCVRCRESHSRAFLPSDDELDVTKIKEEEVDQVLPLFHGELPPSPQSDYPISPVSASPIQYDFVEGRRQSELMWSDVELLGPDTVKPHDLEDESWLESGTSWDHAESSAEDTVRRSHVPLAVTDPKFPVRTQVRVPPLPPRLDLTATGNQNTVKKEDGIRPPEVATPSLISSLTTLSICTPTSPDAERHDSVSYPSPSVQTNAPEGESRVELTYFNEASVHICACTPAISATQFEGIFVYQMSLGSSVALRRIDSDFVNFSPIARCMGIQSPSVLHAVVVTRGSPAVRGTWVPRAVAQPLVEDHPELALFLSDSLHGRFSSLLPDPYHATSCQPDNEFGPHFQSTVDAERSREALWEPGIDSNWESEDHLFPVHPPFSLASIPTPTSFPEDVTIPETPLSPTEEEMFHVLCAAPDWEASPAVACPVVASAAAVTPSMVPLAVTSPESPVMLTSVPPAPTPLAAVTNCSEDCVVNNEPSTGVVKDSACRDRPLRRSKRVANAIANSRSRTRSNKRGSRSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJX4</accession>
    <name>A0A401GJX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0408440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613373.1">
        <property type="nucleotide sequence ID" value="XM_027757572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJX4"/>
    <dbReference type="STRING" id="139825.A0A401GJX4"/>
    <dbReference type="GeneID" id="38779377"/>
    <dbReference type="InParanoid" id="A0A401GJX4"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="376" mass="40005" checksum="D3BD25A6B277E336" modified="2019-05-08" version="1">MSTLDGKLWSETPLIFSSHISARLGCNAYLKLENLQPSQSFKYRGISLFVQHALRTHGPDTHLIIASGGNAGLAAACAAKALCLRCTIFLPEGVSRSTIDFMRREGANIVTAGRCYAQALAKAEEVMVADPKAVLVPAYDNSILWEGHASMITEIVQQLPPGMTPAAIFCSVGGGGLLGGVLQGCRSVGWDHVPVVALETLGSNSFYQSLALNPGAFTATESHLPPEGVRAEHDSVHNVNVAHLSTLKSRATSLGASSASAAVVKMALDRKGGLKSVCLPDEFLMKTARSFAEEHKMLVELACAATLTSAYNPALFEKILPSSPSSSPRTVVFIVCGGFKVDLEELEEYRTGVQADANNGSKWQVLCNGEQWALDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL84</accession>
    <name>A0A401GL84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0413010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613827.1">
        <property type="nucleotide sequence ID" value="XM_027758026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL84"/>
    <dbReference type="STRING" id="139825.A0A401GL84"/>
    <dbReference type="GeneID" id="38779831"/>
    <dbReference type="InParanoid" id="A0A401GL84"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="695"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="863" mass="98844" checksum="598CDBDC695F5ED9" modified="2019-05-08" version="1">MLSTVAFTDFLAVLESGNGCINIEAEVDTRSLGEDVKDGKTIANTVAKLVWEVTGYRWPYHSKWNVAAGCIKFRYYCAQSETRQKQSKKSAPTPDKQRDKESMMSFNCRSWLSITTTEGSSVVSVQLVHDDDHIPYCSIDIPNDVEAFVAKNASMTPTQLWKEIIDKYPDAQFTKKAIYQMWSEADSKNWKRDGNELKSAKILLEEGCKNSSGLYTVQPVPIASPPGLTTIAFSLPNILRQWGGRIRELAMDSTWNTNGSRFELFAILGEAYRSGLPLGYLLVQSSADAEQGAKQDVLEQFLHQLRSQWNLRIIITLSDKDWSEINALRRIFPDAKHQLCFWHALRAIKTRLSILRRMPAHYDIEEAHQEFTFIDVDFLPVSQRQPSSTQYQPRKTALPQLQFRINGVLQPLVPQEHRLMLRLPRRPTIRSEDVVHVEIASGSGTSSEEEDNSESDAAAEQSLQQHHHSNVMEDIGEDIGDGADSGDIRDDVNGKSDEDETDAEDAPDWVFDMGEKKSADPTYVFCPAPHRKALLHLFTKHFCQHPLFIERDGKSHTSEQIRRDAVYEMYLFCQIRGLTEVWAYMWTSWYSHRRWHLWARSTTPWISRARTTMNTENHFKQVKHDFLPHLLRPRLDQLIWILSTKVVPAYMKRAQELEDTYRIGRSKKLTSYQIRFKKAWRTLEKKPISNSGIDYHVNVATWTCGCGNQKYNAYHLCKHLVQAVVKPPPRFFRQVVRRRTIPIYCHPDLRPKMLEGQDVTPEPAEASDGSITDGDDHLWLGNKEKLKGGSWREMTQRSVAESILGKRSREEAMSEGDARDAAEQKHESIETSDLQSGAEDAEDEHSEIDSDEVRAKTEVELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLE7</accession>
    <name>A0A401GLE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613916.1">
        <property type="nucleotide sequence ID" value="XM_027758115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLE7"/>
    <dbReference type="GeneID" id="38779920"/>
    <dbReference type="InParanoid" id="A0A401GLE7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="274" mass="29076" checksum="1EBC50885BA3BF67" modified="2019-05-08" version="1">MDSLISSPANPNLNSNHGPRASSIPQEVHLNPGLATEASRAYHGPHQHSYPGATQQLESWAQGSGVNTHARIDVHPLVRHLPIQTASEHARRPNANTLGAQARSNSGYTAVHASAGFYPGFTAVQASTPSHIFLPPSVPASRSARHRNETIAQAMAAPPAAFSAPISSAPRVVSASEYARRQPSPIQPSPMPYFLTPAPPYEALPSYDDVAPPMPPVSFTPVIEEDGHTAESGENEARPENGDGEANQEDEENQEEVEIGLLSPIAINVSALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLX1</accession>
    <name>A0A401GLX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0502330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614099.1">
        <property type="nucleotide sequence ID" value="XM_027758298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLX1"/>
    <dbReference type="GeneID" id="38780103"/>
    <dbReference type="InParanoid" id="A0A401GLX1"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 11" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="168" mass="18852" checksum="F0D05992FDD97A92" modified="2019-05-08" version="1">MLPQLSSRLASCIDHDPIVTLQLQHDARYYLGKLYFDAVAYGTEELGVKRTGTRITCTRQQTDAVRDGPPVLPTLEQHGEVEEHFIDTLFPPALLENGTVPEGDFYRPTEFTAMDDRKPLVPKHGNSLIMQLILNGMKIQACRPSFLDARDAILNVDKIKCSNKCPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN14</accession>
    <name>A0A401GN14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614519.1">
        <property type="nucleotide sequence ID" value="XM_027758718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN14"/>
    <dbReference type="STRING" id="139825.A0A401GN14"/>
    <dbReference type="GeneID" id="38780523"/>
    <dbReference type="InParanoid" id="A0A401GN14"/>
    <dbReference type="OrthoDB" id="3159957at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="263" mass="29083" checksum="D358F72960714799" modified="2019-05-08" version="1">MKSCDERVLLLRDASLLVTVPTDNGLCVALKNFDDIRQNMTISLYDQEQTDQDLLSYFDKSASAVRQSFKHFEQEYARPALNYFLEFSRSRPILATFLGVFSTFSVLPVLSFLGFSLFVFASCIFFSLAGALFVATTIVLLSGLLLVGTLTILFFLSLFLTACAMGIYLSLRFAVLINKDGPRTGVPEWYQETKKSLLASQPGEDADASGHQPNEYMVRSDSETLIFDSFPTAPMAQAEADKPGAEVPEGDLGKDMVVVVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNL7</accession>
    <name>A0A401GNL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0508720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614728.1">
        <property type="nucleotide sequence ID" value="XM_027758927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNL7"/>
    <dbReference type="GeneID" id="38780732"/>
    <dbReference type="InParanoid" id="A0A401GNL7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="206" mass="23680" checksum="FB03AB012010D476" modified="2019-05-08" version="1">MSAQSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVRWEEGLRWEMFAVRGICGDLALAGHADHIDHGGVIASVLTICTFNREVLRPISIDVKAIPRPTTLVPHPKNLLKDSPDYWWKWDRQVGPAGSPMEAWWYKLGDPWEKVYTVSESTLVQLEQLHVRVANLTSWLHERTDQNLDVVLEELQEATRQLRELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP00</accession>
    <name>A0A401GP00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase omega-like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0510300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614884.1">
        <property type="nucleotide sequence ID" value="XM_027759083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP00"/>
    <dbReference type="FunCoup" id="A0A401GP00">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GP00"/>
    <dbReference type="GeneID" id="38780888"/>
    <dbReference type="InParanoid" id="A0A401GP00"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="163"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="313" mass="35618" checksum="BDF515AAC2D1DC5B" modified="2019-05-08" version="1">MSSTKPVSDASAVKFVELEKDGSFERKASSFRNFIEKGGQFKPEKVGTNSWATRTLIVRKLKGLEDFIDVLVVAPPTGWESMPAASPDTFPGPGCEPVCKYEEFKGRYLQAEPNYEGRFTVPMLWDTKTETVVNNESSEIIRMFNREFNEFLPADKAAVDLYPEHLREEIDSINEWVYDTVNNGVYRAGFAGSQSAYEAAVTPLFESLDRLEKILAGRDYLVGNQLTEADVRLFVTAIRFDVVYYGHFKCNVRSIRGGYPAIHLWLRKLYWTNPAFSSTCRFDHIKTLYYWSQVNVNPHRIVPVGPVPDIVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP65</accession>
    <name>A0A401GP65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614852.1">
        <property type="nucleotide sequence ID" value="XM_027759051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP65"/>
    <dbReference type="GeneID" id="38780856"/>
    <dbReference type="InParanoid" id="A0A401GP65"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="13057" checksum="91CA740B4B3B656C" modified="2019-05-08" version="1">MMNSFPNLSLGRPSPVPSAYIPPTCHGVRPYTVLVDPLPSSLSDIEVDSESTREGVFRITTVPHKRKGLVACQRTRKGAVSDKWPCSSLSLPPVATLWFSPYSRTVRTTLKNAYKRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPA0</accession>
    <name>A0A401GPA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Docosahexaenoic acid omega-hydroxylase CYP4F3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0600320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614968.1">
        <property type="nucleotide sequence ID" value="XM_027759167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPA0"/>
    <dbReference type="STRING" id="139825.A0A401GPA0"/>
    <dbReference type="GeneID" id="38780972"/>
    <dbReference type="InParanoid" id="A0A401GPA0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="487" mass="54622" checksum="3A48159FBBA9F300" modified="2019-05-08" version="1">MLYVSDPKALHSIIVKDQYVYEETPTFLRLNRIVFGTSLISTLGEAHRTQRKMLNPVFSIAHMRYMLPIFYNVANKLGSAVGARVADGPQELDMLGWMGRTALELIGQGGLGYSFDPLVRDKADAFGDALKMLLPTLTELGVLRFAIPFVVQIGTPAFRRRLVEILPSRRVRKLRDVVDTMDQRSRDIFDARKAALKEGDEAVLRQVGQGKDIMSILIKANMETTLEEDRLPEEELVAQMSTFIFAASDTTSNTLARILHLLAQHQDIQDKLRQELLTACQSDAPLSYDRLMQLSYLDAVCRETLRVHPPATMLDRQARKDMMLPLSEPIRGINGQMMSEIPVPEGTKVFVGVVGSNLNKALWGEDALEWKPERWLSPLPNAVTEARIPGVFSNLMTFLGGSRACLGFKFSEMEMSEYCMPLSRVGKIDEFPPGEVVLAVLVPKFTFELTAKPIVWNMAPVRYPTVGKESVKAEMPLKVGLFKKFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPW1</accession>
    <name>A0A401GPW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0602340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615169.1">
        <property type="nucleotide sequence ID" value="XM_027759368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPW1"/>
    <dbReference type="GeneID" id="38781173"/>
    <dbReference type="InParanoid" id="A0A401GPW1"/>
    <dbReference type="OrthoDB" id="3270804at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="1">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="126" mass="12604" checksum="F0720997C5D070AC" modified="2019-05-08" version="1">MGPTAPAVVAPGPTIPVGPAAPAVIAPVGVIGPVVPGVPPAAPGFDIPPGFTATLGVDLPYPAQLNDIAPFYCITRGCIVGVYTDWSLVAAYVHGVLGAFCKKHPTYTAAISAFNTALARGTVQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQR8</accession>
    <name>A0A401GQR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0605450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615479.1">
        <property type="nucleotide sequence ID" value="XM_027759678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQR8"/>
    <dbReference type="GeneID" id="38781483"/>
    <dbReference type="InParanoid" id="A0A401GQR8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="70" mass="7791" checksum="6B08BEEAB3A16860" modified="2019-05-08" version="1">MAQKRIQEPGTQQLPRIFPEAPDALPRILVVMSISSTIRAKPATLSSVPDESLLWSVVSVDGGFLRRRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR77</accession>
    <name>A0A401GR77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0607410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615674.1">
        <property type="nucleotide sequence ID" value="XM_027759873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR77"/>
    <dbReference type="STRING" id="139825.A0A401GR77"/>
    <dbReference type="GeneID" id="38781678"/>
    <dbReference type="InParanoid" id="A0A401GR77"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="61"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE84761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="657" mass="71976" checksum="BC6180C680B8F5DC" modified="2019-05-08" version="1">MSSAAVLEKAEGDPSRFEDAASFEKKGKQYGNLTALAQAAATERALTPLQAIRTYWRAFFWSIFMCMGALLSGYDSQVGGGLLSVPSFRRDFGYEADGGWVLAARWQSSFNSVSSIGSMFGGFSLGYISDKFGRRGAVALCCLVSITGIFIQFFTPPHKNGMLLAGKLINGYALGMYVSGASAYSAEVSPLALRGITTASVNLWIDLGQFMSNGVIEGTGNFSSAYAYRLPFALQWIFPAILLAGLPFAPESPWWLVRKGRVEDARKVIIRLAGDSTDIDLQLHQICETIELEETYAVNSTYMDCFRGVNLRRTIIASMVFVLQQAAGIVFVLSFSTYFFELAGFADSKAFQLGVGVTALGVVGNLLTFYTVNRYGRRFIFNWTMLACTVVLFLIGFLSIPTSQGAKWAMSIFTLVYNFIYQTGIGPLGYVIFAEVSSAKLRSKTIGLGILTNSLCGMVANIVIPYLVNPDEANLGGKVGFIFGGLAAIGTIWAWFYIPETKGLTVDQIDTLFERGISARHFQSINLEEEEAHVGDTYPLSHYEVSGNKEGSPVVFVHGGPGSGSDAKDRSFFNPAKYKIVLLDQRGAGMSTPSAVTEENTTWDLVKDIERIRELLNIDKWHVFGSSWGSSLSLVYAQAHPNRVKPYTSWYLHPPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRN2</accession>
    <name>A0A401GRN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">SCP_0700680</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615801.1">
        <property type="nucleotide sequence ID" value="XM_027760000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRN2"/>
    <dbReference type="FunCoup" id="A0A401GRN2">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRN2"/>
    <dbReference type="GeneID" id="38781805"/>
    <dbReference type="InParanoid" id="A0A401GRN2"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000004">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="143"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="233"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="537"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="789"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="1049"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="67"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="747"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="818"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="GBE84888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1116" mass="125339" checksum="F1910DEE433D2FF4" modified="2019-05-08" version="1">MAHELDQKIQDVYKRIQTERKVLEASHLLRQATTNPDVLRRNDAKIREAERSLSYFEDTLRELQSRKMMQAQRDDHSRSGSPVLSTASGRGGRSSDSPRMHQPTLSDVSSGRGARNPQGSAGSADDIPGVPKAKTYTKLDLIKADTPHTTAKISRMLHQLEFKLLVEKQYKSGIDKMAKLYQADGDKKSRADAESKKVESERKIQLLQSALKRYKNLHILDDAEDDDDDAGGVPGAPGIDGERKDNLRSKNLSGKLQVTLKGARELDHAPIVTGRSRSASKQVETYVSLKVEGTERARSHPTRTDRWLEDFEITIEKANEVEIAVYDKQSNETHPTPIGLLWIKISDLVDAQRRQKVMMENGQGGWVTAGAMNGDGSAISMQAQTGNVGDMNAPIGFGDNRVVPPGSGMPPVGQSEGIDAWFAVEPAGALALHLNFIKENVRKRPLDTPGGLGRQGAVRKRKDEVHEMNGHKFVQRQFYQIILCAFCNEFLLNAVGYQCEDCRYTCHRKCYEKVVTKCISKSNTGEDDAEKINHRIPHRFEPITNIGANWCCHCGYMLPLGRKNARRCTECDITCHANCAHLVPDFCGMSMETANQLLRDWRDINRARGAKSTAQARPIAHYQQPPRPPMPPPEPQVDHIITDVERVKLGEPAVPPKGADYPYGRQQVQSPQETTPPDQRMVQPPLPVTGAYAPPQPRPLPGGRIPLVPAFPSETLQQQVPSGRPGSMLYEDSYAYQKTVQQAVPPKDYAPPPSPGRAIQPERQASLAPSIQQQYRPPAHKRKVGLDDFNFLAVLGKGNFGKVMLAEEKKTSSLYAIKVLKKEFIIDNDEVESTRSEKRVFLAAARERHPFLLGLHSCFQTETRVYFVMEYVSGGDLMLHIQRRQFSLRQAKFYACEVLLALEYFHANGIVYRDLKLDNILLTLDGHVKVADYGLCKEDMYYDKTTSTFCGTPEFMAPEILLEQRYGRAVDWWAFGVLMYEMLLGQSPFRGDDEDEIFDAILEDEPLYPITMPRDAVSILQKLLTRDPKRRLGSTEADAEEIKRHAFFKDVSFDDVVNKRIPPPYFPTVNGTADTSNFDEEFTKEQPTLTPVHAQLSSRDQAEFNGFSWVATWAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRW5</accession>
    <name>A0A401GRW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Meiotically up-regulated gene 56 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0701380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615869.1">
        <property type="nucleotide sequence ID" value="XM_027760068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRW5"/>
    <dbReference type="STRING" id="139825.A0A401GRW5"/>
    <dbReference type="GeneID" id="38781873"/>
    <dbReference type="InParanoid" id="A0A401GRW5"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prospore membrane adapter protein SPO71 PH" evidence="3">
        <location>
            <begin position="321"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Mug56/Spo71 PH" evidence="2">
        <location>
            <begin position="852"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1019" mass="115414" checksum="576DA7EE65C79305" modified="2019-05-08" version="1">MASPTSIPPPITITPTLEAVTRSDLHEHRRRFIGPLPERALSAELKSKGKRKRACRKSITTSANGSETSDDDSDSSLHDAIHHHAFQFFVGHGGRREDWDEDKERHIRAEMVQRWRESEWGKVRSEHKDSARPATQWIGTSFDIGVFLGMNILADSPPQQVASPVAEAASSRRAAPSAGPETFVTAPSCFSAARTPQSGRLPSLVAGESSQGYNNASSSGKQLLNYSKLAGPNSANSSTPLLRSSLDVRQERPGQIPFEETNVSSLNKGKARMVHYSEVSADERPISPLKVLARSGEAVQDSSAGAAEQATAENQVEWGEVIMRDRMFVRMCYSEQPLPSPNFDESHHRTTRNLENERWIEYIVAWRKDRLELYKDHFTPGKDWLLGRKELNYVIPLGSPQTRLSLYSFVDSTFCLLCPPTSPHSDTKRLRHLLGTKGGTNIFIFKHKSRTRAIDWIWKLWRHLGGRLPPYVDIRCPAIDTHISIDIPHYDGADIAAAYTVFNKQNIISLCEHRLKTVHEYKTLIEDKLAEGARMEMAWRFETSLDWVWQLDDVQGKPREWAVLCGLALKQSRRASHLEIRLKEHLPSHLHLNDGTRLDEPPAVEGYLERVKPNSQLRQAVYLTTHGGYLFAVNRSHANHPLPRDLTLNRYGIDDVDAIRRAEVQRGMRQVLHTTGMTDLRGIVAVRRAFQLVPQHAAAPESEAASWEDTGDFWQDVGRSESDEEDAGGDEGMANAHDKSTLRMRRSFELLMMTGHVVRFEAYSCQTALEWIVRLRPLVSYWKKRHKVDARQEMDISHFSTGRERITPKRRIDENEDSPPEPIPDPDTSLPELGSFFNWCVLEGCRPLLKCGKIYARQGLRGQYLHMQLVLISGNLVQYRITGRPSLHHRKHKVISLLDAYVCSGYLAAQYLPDGQYDPNTPPAARRYQDGLEADDSEEDTLFLVWYRKSGRTDTLSPGGPAAEVPPLSGKRKLEIFRTRSKLERDAWVWAINSAIEKVVRASQTWEDRLREAGQLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS42</accession>
    <name>A0A401GS42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0702470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615974.1">
        <property type="nucleotide sequence ID" value="XM_027760173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS42"/>
    <dbReference type="STRING" id="139825.A0A401GS42"/>
    <dbReference type="GeneID" id="38781978"/>
    <dbReference type="InParanoid" id="A0A401GS42"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="394"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="495"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE85061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="591" mass="64789" checksum="5A9314B6558F94D0" modified="2019-05-08" version="1">MTTTIQIPSGPHTSSSPRSFFDWHESPSDRPYPSTLPALSPSSRSSSLESDSDSPRSPVSPTSPWVIAAAEAQVGVHYVRERFPASGTVCGAPPFVHEPLLVRADDRVALLEEEGDHALRVRVIATGEVGLIPIWNVEGALERLARLNMEFNEAATCPVESRYLRGKRGAEASIAHMHSRCIPFAMRYPLSLHTHEYEVDESFDEFDADDEDVPVSARRQKSVEFAKCEHPVVFRYPSESLVFGEDEGTDIEDECEHEWWSGWEEDKEKFEVRVEVQEYSSEKSAPFQVPQFTAKDYSSFFLAGALCCTITHGGMTPIDVIKTRIQIDPDLAHQSLLSGGRRIVAKEGPSALLTGFGPTAVGYLVQGGAKFAGYEYWKKQFVQIAGSQDAAVRNRTAIYLGASSVAEFFADILLTPLEATRIRLVSERHYATGLTTGFMRLTREEGLRGLYAGFLPILCKQIPYAIGQFTVNEFCHELVFRNISEQTRANLSSSAKFTIALGSGVVAGFAAAILSQPADTLLSQINKGHGPSGSMVYRLRTLAVQAGFRGLFAGLGPRMVMTAGLVSGQFLLYGAIKDMLGAPPGLEIHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS73</accession>
    <name>A0A401GS73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0702780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616005.1">
        <property type="nucleotide sequence ID" value="XM_027760204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS73"/>
    <dbReference type="GeneID" id="38782009"/>
    <dbReference type="InParanoid" id="A0A401GS73"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="181" mass="20470" checksum="6021A7FF98307F77" modified="2019-05-08" version="1">MDLHDFEELTLSFPVPLPVLTRDLAQLRDSLAEVDVAQVLPRWRSDPRELASSCRVRAPLPALLRMLALPIIDFQPLSTTSLSSFRVIAHCLRMLEIGHSSAQKIGDPAAFVAYVFPGLQLEGMMEAEERTVKNLSMLRRRGAALGRVWRDVLKLLVESKSTNAPPVEKQSRRRETEMRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSJ5</accession>
    <name>A0A401GSJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein MSP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0703250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616052.1">
        <property type="nucleotide sequence ID" value="XM_027760251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSJ5"/>
    <dbReference type="FunCoup" id="A0A401GSJ5">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSJ5"/>
    <dbReference type="GeneID" id="38782056"/>
    <dbReference type="InParanoid" id="A0A401GSJ5"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="117"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="39239" checksum="D38CFF9F7134AD91" modified="2019-05-08" version="1">MSVSTTTRRVILDVVLFAASQVALYYTVRWVMDGFMPGEKKEVNAKSLKALEKMGHVDLKLDEYEKQIASEVIHPDDIDVQFSDIGGLEPIISSLRESVIYPLVYPHLFSSSSLLGAPKGVLLYGPPGCGKTMLAKALARESGATFINIAASVLTNKWYGESNKLVAGLFSLARKTQPSIVFIDEIDSFLRERTKGDHEVTGMMKAEFMTLWDGLTSSTDRILVLGATNRPNDIDSAILRRMPKRFSVGLPDLDQRQKILSLMLTDTELDPSLSLRTLAVELEGLSGSDLKEFCRNAAMRPMREFIREADDKQELLDRCNEEGFKLRPLTFEDFFHSDNTSSLASTIVEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSU9</accession>
    <name>A0A401GSU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616176.1">
        <property type="nucleotide sequence ID" value="XM_027760375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSU9"/>
    <dbReference type="STRING" id="139825.A0A401GSU9"/>
    <dbReference type="GeneID" id="38782180"/>
    <dbReference type="InParanoid" id="A0A401GSU9"/>
    <dbReference type="OrthoDB" id="2652955at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="265" mass="29330" checksum="1E4CECEEFD70647F" modified="2019-05-08" version="1">MFRHPRRTEGKTFVFNAVIDLPGGDEVVVLLRYFNQHNFSFPDGSYYQINANVAKIIPGVNTHYTSAIAEADRLDGEEFDLMGDVIWLTPLEKNPAPMHGPIMYAAGAVADVDKGCSQFNLNTEQFITFARDLASISKTMPSDGVGSVQPRTGHATLTLHATIPDSPRWKKNAKPMPSNGKYVYVQGLLRKVDRETRKDSSNREIEVATMFAFDVENITFMGSVSAKTLPTPAEPVVTVDSPTVNGAPQSARKRLKAVHSHLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT38</accession>
    <name>A0A401GT38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0700840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615817.1">
        <property type="nucleotide sequence ID" value="XM_027760016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT38"/>
    <dbReference type="STRING" id="139825.A0A401GT38"/>
    <dbReference type="GeneID" id="38781821"/>
    <dbReference type="InParanoid" id="A0A401GT38"/>
    <dbReference type="OrthoDB" id="3515175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58620" checksum="1BC41B952F62168D" modified="2019-05-08" version="1">MVLHIRRPSTAASRPITTSGATAAFPCALHTDLTVGEDAYSSDVTFQNSLLSASMGSWDGDNNDGISVIDVTDPENPAYCFVTTDTPLSAEQYVRHYYPVPTEESRDPERSRLTGKTVLETIGLLDGEKLVTLDMLAEVWPDEYQSEAVERPAGDIAASTSAATEPAEEAPIPSLATLAFAQAFDHALGKGDTSEIENLLWLPGKLADTKSILRTKSPFPDNAVQLLVKVLTEMKETTSVDLTDFALSSEQAVRIASQLPGHESLNLSFNAQITADTVREILTAAPGLKRLVLMGCTSVTSKELYDLLRKEPQLFYRLEALMHPSLLCTAEPPPYPIAFTLMTSYESIMPSIRGCSLALFTLMGVVGALADVLRSFRSARRIVFDMNSGTPFQAAATARPREPGMPWGTRSLVTVPALSVDVLRAVEPGWAFLFQMSMFHEKNNWCFLRLTPTERNQEEAVQEQPWPPREWEIHDVRGFLRIATAEGRPAPSEEAVQELEELLRHTPKFGSQLCLMDHQDLNVFMQSIHMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTE5</accession>
    <name>A0A401GTE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0800180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616414.1">
        <property type="nucleotide sequence ID" value="XM_027760613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTE5"/>
    <dbReference type="STRING" id="139825.A0A401GTE5"/>
    <dbReference type="GeneID" id="38782418"/>
    <dbReference type="InParanoid" id="A0A401GTE5"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051515">
        <property type="entry name" value="IRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32341:SF10">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="6">
        <location>
            <begin position="90"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE85501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="317" mass="35133" checksum="040D3779CE948CDF" modified="2019-05-08" version="1">MVNPLTLKVSLRTTGTCLAAVLDCTPLVIGCMAGVVVIAGAVQLYRMMISGPPGSRREHTTRSLPVQAEQHLTISTRDQVIRERLQYDDSMFNFAVTGNSGSGKSSLINAFRGLRNGQRGAARTSANCEGTSSAMRYPHPHYPQVWYDIPGAGTPNVPGGQYFRAQGLDVFDCIIVLIDMRLTETDIAILRDSAQSGIPTFIVRSKADQHIRNIQADMEESDHEDAMGRYLRAREACISETRICVQGGLHRADLPQQRVYLVSKDVLRELMCCISEVLAARGAKMDEQQRNFARLQRFDVIDEYALLSELLELANEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTF8</accession>
    <name>A0A401GTF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0800140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616410.1">
        <property type="nucleotide sequence ID" value="XM_027760609.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTF8"/>
    <dbReference type="GeneID" id="38782414"/>
    <dbReference type="InParanoid" id="A0A401GTF8"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IRG-type G" evidence="3">
        <location>
            <begin position="1088"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1314" mass="149310" checksum="9535598107249944" modified="2019-05-08" version="1">MVSARSHTPSPEPAPRPMLSSRSDLPEAPSSSSALPFNETTQTINERHAEAADSYVVGPMPVEKFLNFLPPKNVALMPPSAGAFDKLADGNVALELCKAITDHDRCPRFDFRYSGPENEEEMPALVCVPHGSDSVPAAKSEMYIDVQGAAQGDFMRDPPCGVDRSRHKFLLLLEHAEQTGRERARQAFGRNVRWATDACGQQFRTHFFSISLHGTSARLMRCDMGGMIASEAFDVCEYPEILCEFLWRFAHASTAERGYDPTVSPATALEEGMFKNIIAAYVNYQLDLRRNLMYILQALAHHYQPGRVAAIGIVQPDGTVARCIVSRPISKFFSLRRGGMRGYWGVMRGKIVFVKETWREWTLVKESEGAILERLHKEGVHNIPSLVCHGDVPERTDECAAEFQYTQTDRYVSENWVCTGDRKIMVRSRVHYRLVLGTVGYPLHALRGTKELLSATFDVYSGMIYAFLHGNTLHRDVSLENIILVREGEDRLRHGYLINWELSSQMTEEKEALDEWTVGKDAFMSHRLQTRMAPLRQTMRDDMESLLYVVAYCGLHWLPHRTRGAHTAAQALFYNVQVGRDGEGMTVRSMAPGEGKMENKRSRKHVNPAFFRKPFALWLQGAMDLNCPRAKCAGAIKVGDAVFPDETQWASPLPLYDFWVEFLNKHERKLHTQDRRKNFERDEADLALFSATRAVEHHTAPRPGKRKASSSPHPVERMLKRRRITTPGLISYKVCNAAYSWDWFPGSHTALSTSYIFAQAAVLTDHTPLFYITLKHHTEASNTNHPSISYYLQQSSMGGIVSAVVSVTTAVLGLIGLIRKFESPEESGQQIAPNPVIQELEERAREAQAQREQVERERSEAEEGRRLADEARQRAENETVRLQEEKKRAEHEKREAEESKRLADEARQRVEGERRRAEVEKQHAEHAKREAEEQRRQADENRQRAEAERWRAEEEKRRSNEEKQKAQEEKRRAEEAGRKAEDERQQADEKRRHAEKERQQAENNRQRAEAESRNAEAERKRAEDAKEKATAAKEDAERASAAAEKAAEEARRAQQEAEKNLRAGIRPVVLPTEEEIRIHKERLQYREGKLHFAVAGIAGSGKSSLINALRGISNRHKDAARVGVTETTKIIARYPDPNSKRPFVWYDVPGAGTLAIPDWQYFNDHGLYVFDAIIVLFDNRFTETDVALLRTAALFQIPTYIVRSKSNQHIANLLTDLEFGEEEDDASRRATARQIYITETRDSVAHNLFEAGLPGQRAYLITAKEVLCEVVKGRTPKDVIDEVDLLSDILQEAHSRRVRAKPSQTSRHASYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTX3</accession>
    <name>A0A401GTX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616594.1">
        <property type="nucleotide sequence ID" value="XM_027760793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTX3"/>
    <dbReference type="GeneID" id="38782598"/>
    <dbReference type="InParanoid" id="A0A401GTX3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="476" mass="50183" checksum="1ADDB0F248EEDF9C" modified="2019-05-08" version="1">MFSTSHPHITSMHGMWSFAHSHAACNDPLPTIDNTNDFASDSFGTIGYTAESVNLQTGGSEVEIDQWWQSQSFNGVEATLSDDMMVSLFGPDPEVAGGFAPSPTITPPFGSDSTSEFVANVGCKRMHSPRLIAHPTTEPAPLLVHPPTSVATLASGSQLVTVPVPSLTTTAAQASPVTPTPDSICVPKTGKRTKRTLSDSDSTESSQMEARPAKKTRKSKRADAAAGATPGAAKEDTDYESSTFGTLLQIMQGLATKRWSPPQEVIDLTIDEDHPTTVFKETKRELGEFTKRVLAESVPKGARGGRICGPVKSVAAPTLASVSEPRSVSAVTTETARKGRAVVTGVGDGSPDAVPAAKKKAAAPRKNKRANKGKATEGKDGLQQTANRTVPASLSSIRTKNKWSQRNPDPPALPPPVIAAAVDFVHRPSSSTSESSVVRSSESSNRSTASPHVKSAPAIPMPVVANPVIFDFFSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUK8</accession>
    <name>A0A401GUK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0804390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616828.1">
        <property type="nucleotide sequence ID" value="XM_027761027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUK8"/>
    <dbReference type="GeneID" id="38782832"/>
    <dbReference type="InParanoid" id="A0A401GUK8"/>
    <dbReference type="OrthoDB" id="2788070at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28691" checksum="1C2643AD1EA85C15" modified="2019-05-08" version="1">MLFNYAVCPAGNSIDQTSTEALAPGDIGICRPGLNGSVLAKLPLLTEGKSFAFLKKSLSDVGGLEWGEMSGSFQQEVKVRDSERCIVTGTPSNEASLVISWIYPPFLASFDMEEDITQYLSVTNALTMREDLAKGFEENEFGIDVDDNYRIVSFVPSAPSYLLPHTHLDLSHFSPNVRPNEQYLRRHFIMCLVVNFLGGDISKQYEDIDPDEFWEERGVFDEDYDFNEPEWHTELGREAKALLLRRWPGRYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVZ2</accession>
    <name>A0A401GVZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein pet117, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0902310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617265.1">
        <property type="nucleotide sequence ID" value="XM_027761464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVZ2"/>
    <dbReference type="FunCoup" id="A0A401GVZ2">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVZ2"/>
    <dbReference type="GeneID" id="38783269"/>
    <dbReference type="InParanoid" id="A0A401GVZ2"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="83" mass="9788" checksum="3CC73C259B08595B" modified="2019-05-08" version="1">MSRAAKATLIGSVFASAFIIWGVHHLQTRERETMYKGVIRDDERRREKMRQREEDLHESLRKREIYERVQPVSSSATRDSGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW94</accession>
    <name>A0A401GW94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0903770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617411.1">
        <property type="nucleotide sequence ID" value="XM_027761610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW94"/>
    <dbReference type="SMR" id="A0A401GW94"/>
    <dbReference type="FunCoup" id="A0A401GW94">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW94"/>
    <dbReference type="GeneID" id="38783415"/>
    <dbReference type="InParanoid" id="A0A401GW94"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE86498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="257" mass="29065" checksum="90D89E9025F2F603" modified="2019-05-08" version="1">MPSTFADRPLNKLILFDVDGTLTPARQTVSPEMVQLLRALRKKAVIGVVGGSDFVKVAEQLSVPGSSVVNEFDYTFAENGLTAYKLGKLLPSESFIQFLGEERYKPLANFILHYIADLDIPIKRGTFIEFRNGMINVSPIGRNATVAERNEFEAYDKQHGIRAEFVKVLREKFPDYGLTFSIGGQISFDVFPTGWDKTFCLRHVQDETFDEIHFFGDKTYKGGNDYELYSDPRTIGHSVSSPEDTMRLLNELFLNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWA4</accession>
    <name>A0A401GWA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0903870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617421.1">
        <property type="nucleotide sequence ID" value="XM_027761620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWA4"/>
    <dbReference type="GeneID" id="38783425"/>
    <dbReference type="InParanoid" id="A0A401GWA4"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="468"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="494"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="552" mass="61208" checksum="4F85D8D41A195F67" modified="2019-05-08" version="1">MNVLAQSRIRALSDFVTVLDHQSVLGIVNILDECSTLLAADQSNRQIFGQADDSSIWPTLRYLWVQTVDAYEGVGPVDEQQSALLCLSVARFTRNLSAGVPSNQERAFDNEPAIRKLVHRYTSFSVMQDPKSFEITRMLVQTLSNIVTTNEALSQRLWSIYTQLPQKDSILIRLCASPDAKTVSTTFVLILNLIHNSQERAEMLITSATGPRICISLLDCILSLFDAEESTHHSQAFDVGYQILVRLFKAGLVKKLYMRIAVVGEVISPHQTTLLKLLDSYLQSLPYREVVGENDELLQMLTSTFFSLSRHMKIAIKSTLGTAAASERVNLGLSEASISLPLSETPMEPPGYRNPQEIDLLLPKVCEALVLVVQCLTSILLAAELDAPAADAPSTRANRASDLRSPRRYISEVHTADGQDFAEDLVETLRLLDIFIPRIMLGKVAHRPAPPGSEALQQESPPLGLVYIKRDLVRLLGILCAHNHPVQDRVRLCGGIPVIMNMCVIDDQNPYLREHAILALNNLLQDNAENQAVVNEMKPVGRWDAMGNRVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWK7</accession>
    <name>A0A401GWK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0904870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617521.1">
        <property type="nucleotide sequence ID" value="XM_027761720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWK7"/>
    <dbReference type="STRING" id="139825.A0A401GWK7"/>
    <dbReference type="GeneID" id="38783525"/>
    <dbReference type="InParanoid" id="A0A401GWK7"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="445"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="540"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="639" mass="69029" checksum="E5A63EFA34D8BA06" modified="2019-05-08" version="1">MGASSESAPLSPTNFFLHPLSIATSRYSPPPHSPCFSSASSTVSFSRYQQFSALRTTNEAVLEAMADPRFRSSTSSDPVCHCAEHGGVAPLACEECVQECADAPCTVGLTPECTDQCVVVPCNDAHHQDPPCNENHRANEPCHDGADCTSLEDFFECCTDFHEYFSQPRSFPTDVAPNTPGFTWDTATLEALLCGSPGADPRMSRSQAGSSSNPPLFPHIIPNASIHPSPATAPQKSQGLTEPMTQHLHHQPPLYLPSAEVQVPQTQENQSSAMKCMWGNCSETFTSLSELVGHVNLTHLRLPSPLPAESLSSVPIPAPKSAQALQQAVAANMDPNSLSCMWADCQVYPTPQSIPGPSTRNAVNSVMEVLASHLLEHHLGLPTRSSKQDETLGTFSLTSNISPLSTPDAHSMTTAPSAPILAPASPMHGPPTPLPEHDCSAPSSHICGWEGCGQSFSSCEDLTVHITATHVGGGKAHYDCHWEACSRHGEHGFASKQKILRHLQSHTGHRPFQCKICSQNFSEAATLAQHMRRHTQEKPYACDFPGCGKAFAITGALTIHKRTHNGHRPFKCTYCERAFAESSNLSKHLRTHTGARPYQCTEPDCAKSFARPDQLSRHMNVHRKKSVDETASPIAVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY04</accession>
    <name>A0A401GY04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1003300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617996.1">
        <property type="nucleotide sequence ID" value="XM_027762195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY04"/>
    <dbReference type="FunCoup" id="A0A401GY04">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GY04"/>
    <dbReference type="GeneID" id="38784000"/>
    <dbReference type="InParanoid" id="A0A401GY04"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="563" mass="60784" checksum="7EB58E97CD124ADF" modified="2019-05-08" version="1">MPSSVTYPRYSAVSSNLRSDRVALLSDALETDDEADDSSAESEADSFPGSSRSSVVIPQSIRKHVKTDETECPTEDTPLLLPVPVRGTRKPREPSRSTGKRSVYWEELRTLTKYTLPVFGTQLFEYSLVIASVISIGHLSTTALAASTLGSMTESVTALSIFIGFTSALDTVLPSAWTSSHPELVGLWAQRMVVVLAVVLVPIIGVYFNSEAILLMLKQDPEVAHLAATYLKWSTIGLPAYAFNGVARRYFQSQGLFSVPTYIILVIAPINALLNYVLVWGPKPFGLGFIGAPIASSISFNLISLASIAYGVFFVPRKAWHPLSFRCFTNLGVLVRLGFAGVGQVASEWWSWELVSLASSMLGPVALAAQSIVSVSSSTTYQAPYSLGVATTVRVGNLLGKGNAKRAGVAANLSIYMSLGISMVWSTMFLVFRHSWAYLFNDDPEVVALVASLLPLLALFQVVDGLGGVTSGILRARGMQSTGAVLNFSAYYILGIPFGMWLTFRKGMGLAGLWIGLTVAMVYCAIVGVWLCVRTNWEKEVEKVQLRVAADQKANAGDVEAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYX6</accession>
    <name>A0A401GYX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposon Tf2-11 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1100350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618273.1">
        <property type="nucleotide sequence ID" value="XM_027762472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYX6"/>
    <dbReference type="STRING" id="139825.A0A401GYX6"/>
    <dbReference type="GeneID" id="38784277"/>
    <dbReference type="InParanoid" id="A0A401GYX6"/>
    <dbReference type="OrthoDB" id="3268967at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="211"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="338" mass="38413" checksum="E69F159F6A1E2451" modified="2019-05-08" version="1">MDHRTLENFFRQKELSRRQAHWQEFLVQYDFDIKYIKGEDNVAADILSRLPPDVEIVDPSACAAMLLLRTATHSLCDIPEMIAMSCAAATCLSIAADPAWLLAIRSGYEQDKWCQKLRSTAGSLGIRDQNGLLYVGDRLVIPHVLELREAIFRLAHDSLGHFGFDKSYAAIHDGYYWPNMRTELEHMYIPACEDCQHNKSLTHKPHGPLHPLPVPDRHCNSIAIDFISPLPEDEGFNCLATITDRLNSDIQLIPTCTDISAEAFAAQFFNRWYCKNGLPLDIISDCDKLFISKFWKALHRLTGVRLKMSSAYHPQTDGASERSNKTVIQALRYHVARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYZ6</accession>
    <name>A0A401GYZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618300.1">
        <property type="nucleotide sequence ID" value="XM_027762499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYZ6"/>
    <dbReference type="GeneID" id="38784304"/>
    <dbReference type="InParanoid" id="A0A401GYZ6"/>
    <dbReference type="OrthoDB" id="2682651at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019403078" evidence="1">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="11082" checksum="8B7D6CE170925F58" modified="2019-05-08" version="1">MCPVLLQLQWLLVVETWEKDPSKPNPFVVTRPAMTQASVHLQLVNEEAVELENGEQCGVLRDLISPSVIIMVGIELQEQQYRLRQDTEGLGAHSMDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYZ9</accession>
    <name>A0A401GYZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618301.1">
        <property type="nucleotide sequence ID" value="XM_027762500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYZ9"/>
    <dbReference type="GeneID" id="38784305"/>
    <dbReference type="InParanoid" id="A0A401GYZ9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="172" mass="18927" checksum="75E13F897B8CECD8" modified="2019-05-08" version="1">MHVDRADGPPSFIDTRPTAFIFLSHFDPADIPATPPLSCSPSPEYMPSSPVYVPSSPILSSSSSPPLSACACMHEADCHAMPMHPPGSHARRSSPDSYNGDDNLSGLISVSHGNDSSDSESDMDLEDDTDDNDNHLQSEYEREDLMHERVEEILVEVMRDITEEVVEYNTTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ03</accession>
    <name>A0A401GZ03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Purine-cytosine permease fcyB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1100660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618304.1">
        <property type="nucleotide sequence ID" value="XM_027762503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ03"/>
    <dbReference type="STRING" id="139825.A0A401GZ03"/>
    <dbReference type="GeneID" id="38784308"/>
    <dbReference type="InParanoid" id="A0A401GZ03"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26603" checksum="AA51FF7778FB1416" modified="2019-05-08" version="1">MTPDYGVYHSAKASSVRIFFYTYTGFFLASIIGHILGAAFAASATLYSPWTSGFDNGNNVGGLVAAILAPSGGFGKFLTVVVALSIPSACAPTMYTFASSFMAISHYFAKVPRYVFIVISEAILIPVAIVGAVHFYETFADILDVIGYWSTVYAAIILVEHFVFRKNNFSLYDTEKWDRPGELPLGIAALLAFLCAFGMIVPCMSQAWYVGPIAAAGTGDIGVIVGFTLACVVYAIFRAVERSVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H015</accession>
    <name>A0A401H015_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1104310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618667.1">
        <property type="nucleotide sequence ID" value="XM_027762866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H015"/>
    <dbReference type="STRING" id="139825.A0A401H015"/>
    <dbReference type="GeneID" id="38784671"/>
    <dbReference type="InParanoid" id="A0A401H015"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="28507" checksum="BA18229DA5A7FB27" modified="2019-05-08" version="1">MAPPLIPPSQTTQNIMLLLQQYPILMNEMLVFFCESIHPSAQLLSQILGTQPRGNQSSPSGSGGASPVVVGGVVGGIVSNGDGLRYDLEAPVHRIDLGCEDQYENGRVRDADDRQNASHGITVNAAMEKLGLHDPRDLLPGLEVRLLPHQAIGVNWMLDQERNTPRKGGILARHGSRYVSLDDPGEGDTHRPTLIVVPAALLLQWKEEIETKTNGMFSVHIRHGREKTKSLPKLADKDLLPGCCRCGQSPAYDMRRSDFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Q3</accession>
    <name>A0A401H0Q3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase ssp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1201850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618872.1">
        <property type="nucleotide sequence ID" value="XM_027763071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Q3"/>
    <dbReference type="STRING" id="139825.A0A401H0Q3"/>
    <dbReference type="GeneID" id="38784876"/>
    <dbReference type="InParanoid" id="A0A401H0Q3"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="62"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="659"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="788"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="800"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="865"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="900"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="911" mass="101231" checksum="E49906EDD3BF742E" modified="2019-05-08" version="1">MSDVVAASPDIRDTGPVPGPSTNTRNDVLPHTPNPLNQGVVMTHEIKSSYSRSVNRRMINQYEFDHRVGRGQHGEVYLARDTSKNGMEVAIKAVKRKNQKVDRMSMLRKRNLPNSPHLPLTDQLGSTEHKIRKEIAIMKKCCHPHIVRLLEVIDDKLNDRIYMVMEYLGGGEIKWRTQGDEPVLRVDQTRRICRDVILGLEYLHHQGIIHRDIKPANLLWSADRRTVKITDFGVSHFSYAQRLAAAGRGLSPDDQDPILMDDSDLSKTAGTPMFLAPEILSDSTSESASSSTMYLSPTRKKPPITKAIDVWAFGVTLYGLLFGHLPFQALVEYDIYQVIRKQDWDVPATMGVDLIPVGGRHQKSQPKGEETEGYLVVKLLQRLLEKDAKRRITLSEVKKDPWILRDISNPQEWLRETTLDRQSSLEPTADETSSAMSSVRFRWSALLTNRISILLRNVRPQRSFRRGARRVEEPEEFKDVGTRSAPNVHVHHLPRRSTVAGPSQSRLERQQAIQQDRGKQRQLTRDAPHNQSGTEVSVTAVKGFEPWSMWAGGSTPAIQGSGSKPRRGSIPSKVPEMTLQVPVRGFRVGSPQPSPQSISQATSPIGEQRLASEERPRSRMSISSWVRGWRSGKHTPYGASPQDASANTSPGVNAIASATPSVRRSRSGGAAVRERMARRSEDAFNSHITSRQSSASGPLMPPMRAASWGEVNNYSRPSEDMTSLYSGERADDALDEDTLLLGAGGVAQSPVPSIPSGLLSTVSSTNSTTNPAWSAAQAILQRAEIGEHAPVHDQSVPDMSRQSSTRLRTTSPLSQMPYNHRHLTAESDSVDSYDDDSSIFDPDAQSEVDYDDVALQPSTSQMYQAEDDESEDEEEFQLEVRTRRPSASASPSDTSPRNSESTHTERAIVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0W8</accession>
    <name>A0A401H0W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1202830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618967.1">
        <property type="nucleotide sequence ID" value="XM_027763166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0W8"/>
    <dbReference type="GeneID" id="38784971"/>
    <dbReference type="InParanoid" id="A0A401H0W8"/>
    <dbReference type="OrthoDB" id="3266090at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="21908" checksum="857E34BF7D5A2041" modified="2019-05-08" version="1">MSLTADRYSWYERDENGNLIPDGGTGYKLTPAAVEAEREIYLKRAKERMPTPTTELPDKYNPFLRKDVKPKPPVLQYGIAVNFDQLRSYANEKNLLEPAARKRGVPLSSLSDMPIVYEAIHGLEVACNARLHWAIPWVPDYDGMVSLYSNYSIFWEQLEEEHEQEVIKILQEELGVTVKPMWYWDISNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1X3</accession>
    <name>A0A401H1X3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD-P-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1302080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619306.1">
        <property type="nucleotide sequence ID" value="XM_027763505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1X3"/>
    <dbReference type="STRING" id="139825.A0A401H1X3"/>
    <dbReference type="GeneID" id="38785310"/>
    <dbReference type="InParanoid" id="A0A401H1X3"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="517" mass="56960" checksum="2B40D7C64CE9A8E5" modified="2019-05-08" version="1">MWRLVWPSKPPNCFDRVVIVSYGSANLIIPSGGPALYKGSGGYPASPNFRYTTMADEQSSIPLHALLSISFLVIGGGISGLTSAIALRRAGHRVLVLEKGNGIKNTGESGIHVPANLTKVLFNWGLKDKLLQCGLVSHTMFLTKYTTGEFLGTQVWEEEVLRETRGEVLLMTHRNLVKVLYDAAISLGAKIRHNAEVVEIDAAKRQVTLASGEVLTADAIVGADGPSSLCRKAVMESRDPGKPLGISMYVATVQEEYVSKDLFRSDGLKNNDHVLLVAFGSRQFVMSYPMGNGKYSVHFYTADDVAVGQYGDPPSADLKKLMVNCEPRLLRMAQHAGPAVRVVIKNYTLKADWIHETGHLVVIGQAAHPWPGCTIQGSAMAVEDAAVLGKLFSHLSSEDQIPDFLSAFQDLRQPRVKQIFPNELASVFFSMLEDGDPQQVQRDEAMRAKHKSGVSVLDNLDDSPEWDELRTTFNYDCEDEADDWWLKWGRLREQARSRNPKTLGTKFVMDVQGGVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H233</accession>
    <name>A0A401H233_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1302830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619381.1">
        <property type="nucleotide sequence ID" value="XM_027763580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H233"/>
    <dbReference type="GeneID" id="38785385"/>
    <dbReference type="InParanoid" id="A0A401H233"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14656" checksum="58EE33AF2FBB56C9" modified="2019-05-08" version="1">MASAKLKDVFMDNDSDVEQSLKSDAALPINEPEITEILKKKVNKVFVLLPTPISPSPKFVVQFMLFSDLLIHRLLQQRKEPEQSSPMKKGHNRQSKPDSEAEALMEQSKLNHYNVMTYVVFLSHFTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2B2</accession>
    <name>A0A401H2B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1303880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619484.1">
        <property type="nucleotide sequence ID" value="XM_027763683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2B2"/>
    <dbReference type="GeneID" id="38785488"/>
    <dbReference type="InParanoid" id="A0A401H2B2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="427" mass="47700" checksum="12AEEC93539EC06B" modified="2019-05-08" version="1">MSFMILNPLQYDDDGSLLPRLGLPDWLAGVLNVDMPKSAVYVEETEDIDAAAMFIILVVLVVLVAVLFSVVVTVFVPVLVSIVILVVVSVVVSVLVPVVLVLIKFIFAIAVETTSGPSRSRRKREASSFESPSVDDESSTSEESEAGPSRPRKYRRKQEDDDDDFIPNWESLGPVAGPSRLAGSTAPRCTTSTRGRRRARRAQTMKRAAVPTSTPEEDEDLREETIGGSVQVWYCLYHDCDWVWRSDGKQHEADRMRHMVTHWLAHERCLRLSRERDTVASRVFINSSSNHDVCISATVSVFIIVLERASSILGRRTPFIQPPVGGRPLSWDGRLVYTTSWEVGDRLGDEDLVQFHRVAIGCGRLLRGTRKMILEVTGLHGHVFRHFVGRARGKFVGRSSCYPPPRRWKLSVCVCPLAKTPQSLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2I3</accession>
    <name>A0A401H2I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619558.1">
        <property type="nucleotide sequence ID" value="XM_027763757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2I3"/>
    <dbReference type="GeneID" id="38785562"/>
    <dbReference type="InParanoid" id="A0A401H2I3"/>
    <dbReference type="OrthoDB" id="3007182at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="73" mass="8274" checksum="712626851ACF642F" modified="2019-05-08" version="1">MHVSVIGGIYMKALGLRLTKLKQDADVLIPKSGPWNRFNIINEIAKQDPCFTVNMEVKCGLTFKEGDEVYTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3M2</accession>
    <name>A0A401H3M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1500030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619914.1">
        <property type="nucleotide sequence ID" value="XM_027764113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3M2"/>
    <dbReference type="GeneID" id="38785918"/>
    <dbReference type="InParanoid" id="A0A401H3M2"/>
    <dbReference type="OrthoDB" id="3192989at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1262" mass="143372" checksum="06E3919E59741E25" modified="2019-05-08" version="1">MSRRNKSRLVVDLDDEVEFVTKVAKQTTRGVRYVDVPLPMPTGSNVPSPSKSPSKAPASGSLFNLDDGDVLGNIGVPIQLDPAARKTKTQNDLMRDWIPHRDDYLHAIVEMEAPPEPRNCAECKVGEGRWRCLDCMGRPLTCTDCCRNGHQRAPFHRIEHWQGQYFEPASLYQVGVCIHLGHGGDPCPLGAFTAHNNPAPVVAPGSNFWNASNEDLNAHDGEVSDDGEVPFNFAPLAGTLDGEARQTDDAPDPTWEEDVPPVLSRPPRRDSYGNWIIVIVDISGVHHIGVDWCQCEMAVERDMQLLQMGLYPGTVKDPHTAFTFAVLDDFLLENKECKTAALNYYSKLKRVTSNAFPGTVPDRYRELMWVSRQWHQFKYRKWHGFSHDTLRPVEKGGLTIFCPACPQPGLNLPFDWQADPVQWKFKCDFVMDGNFSAEHMKMKHPEEDVALSDGQAFMVGQEDYKAHLAVAMESHQRSTCHEHRAVNQANVDRTNLDATGIGATACARHGFFVPHTVVDFQKGERQMNMDYSLSNALLTLTGITLVLVMYDIMCQYGVHVRKRFRHSAYLRMPFELKVDQGIGLFHVHGHQDCCFQWFSPNFIVGAGMVDGEVIETLWAPTNEVSGSTRGMTRAHRQEVLDDHMNDSNWKKTTRMVPTLMTKWKRVLLGFPRSKESFEALSASTDEEVLEAWQKEYNDAMEARQNDPKIMDTFDVQLRKAPGKDLTQLRLAGEESAKGLEKGIAGWLSTGLKIQEAQLKLANDIHKAGQNPSVAEDLKTLECRQRLEVSILTFQRRSEKFMGRLEDVPAMEDRDDGALWDSLDENPFQIHPEDAEYGEDAIPPEQASLNLPSQIRFVAAIANGLQTLAAQELELRKGLMNDILHELRMALGLKSYLYRKRVCPANSVGTMTRAQAEVHAADQTVLACARLYSANRRAIMCLDATDEDLALYRPLDKKDLHVKTAVIEASTSGLRNVNLAWFWTMDVAGDRGSLEWMDEFYRVNWLRARARYERWREERVLVHSEMAWTIATFKRNVERWAHWLEMMDPSWRGHVCYAARQSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVRWEEGLRREMFAVRGICGDLALAGHADHIDHGGVIASVLTVCTFNREVLRPISIDVKAIPRPTTLVPRPKNLLEDSPDYWWKWDRQVGPAGSPMEAWWYKLGDPWEKVYTVSESTLVQLEQLHVRVANLTSWLHERTDQNLDVVLEELQEATRQLRELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3P7</accession>
    <name>A0A401H3P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF917-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1500110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619922.1">
        <property type="nucleotide sequence ID" value="XM_027764121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3P7"/>
    <dbReference type="STRING" id="139825.A0A401H3P7"/>
    <dbReference type="GeneID" id="38785926"/>
    <dbReference type="InParanoid" id="A0A401H3P7"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="555"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="718"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE89009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="951" mass="101709" checksum="8FAE1BC19882F725" modified="2019-05-08" version="1">MAVREVLRRAAISPSSVACLSIGTTAFINAVLEADSRRLAKVAVIRLCGPYTRQCPPFIDFPKRLRALTEGYVGYADGGLQIDGGEIAPLNEEQIIEQCSAIKQRELKNVVLSGVFSPLDNDGRQELAAMKIVQHELGSSINVVCSRDVGQIGFLERENAAILNASILTFAQRTIHSFQIAMRALDLSCPLFLTQNDGTLTTASSAAHLPIRTFASGPTNSMRGAAYLAGLDEHHIIQQRKSAIVVDIGGTTTDVGVLLPSGFPRQAAAFIEVGGVRTNFAMADVQSIGLGGGSRVRVCETAKGEQVTVGPDSVGYNLTRYAKVFGGDVLTATDMIVAGGCEEEVGKRERVADLDRNVIEKAKKVIKKLLEGIIDRMKTSPEHITVLLVGGGSIIAPNELTGVSEIMRPAYFSVANAVGAAMAKVAGDVDTIELLQNRNVHAVIESIKTRAIQKAIIAGADPATTKVVEVANLPVQYVTNQATRIIVKAAGELAMNAIASTTELNVITNGDDEPEASEGEKAVLQEVNEEEDLIDIEEYAPTIREDRSWILSELDLEWIAEGCGVLGTGGGGSTYPPFLMARQLLRDGKEIIIVDPDDVAEDGVFLRCMFMGSPSVSLERVQGGVEIPASIRALMTYMGLQDITGAISDEIGGGNGIQPMIVATEMGKVVLDADLMGRAYPNMYQSLPGAFDIPGGLWPCAISDGVGNTVLLPTASNPKSVETILRTVTTEMGSRSGVSMAPLTRKTCQEYGVVRSVSQAWRIGRIIALCRKKNKLRSIPSAILELQNGSCLFVGKIIDVQREVRKGFTWGSVTIVPLLEDEEEDGCPPTNIPVAHGQDDRLVIPFQNENLYAYISSPSGEQKILVTVPDLIVVLDSQNGAPLGTPDYRYGLRVTVIALAGNPKWTATPEGLACGGPSAFGLQDLPFTPIAQYREPSSVITEYALIRPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4A0</accession>
    <name>A0A401H4A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620146.1">
        <property type="nucleotide sequence ID" value="XM_027764345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4A0"/>
    <dbReference type="GeneID" id="38786150"/>
    <dbReference type="InParanoid" id="A0A401H4A0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="11011" checksum="87766F78702218A7" modified="2019-05-08" version="1">MDVFMDVDDKDINGDMSLKPKPEDLSDKKVKEDDTPSWPSVYDSLSVMTDDALGPLSTSTSTSRVHLSSRKMVLCDSSDLIISNMKGIPTSWERPETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4A5</accession>
    <name>A0A401H4A5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1502660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620171.1">
        <property type="nucleotide sequence ID" value="XM_027764370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4A5"/>
    <dbReference type="STRING" id="139825.A0A401H4A5"/>
    <dbReference type="GeneID" id="38786175"/>
    <dbReference type="InParanoid" id="A0A401H4A5"/>
    <dbReference type="OrthoDB" id="3270296at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24235" checksum="9C498981949D172C" modified="2019-05-08" version="1">MLALPPNSLSRLRELKASKEVVCVILQCPCDKPGWRPLETIKGVQLTGSTWDHVFLASLKKYGANALKRLELAGWNEMDDLRRLVECVPKLTWLDVGKRGGPGAANTPQTTSASKPVTVINTNAVEWATLLSNMPELTTFYGVRFFYEVSALAADPSILSLSDRSRVRKNDEVASVFAWKCPKLRRLDHWEEGSGKVIVLLRDGEKIRYEVRRVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4A8</accession>
    <name>A0A401H4A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620132.1">
        <property type="nucleotide sequence ID" value="XM_027764331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4A8"/>
    <dbReference type="STRING" id="139825.A0A401H4A8"/>
    <dbReference type="GeneID" id="38786136"/>
    <dbReference type="InParanoid" id="A0A401H4A8"/>
    <dbReference type="OrthoDB" id="3270670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="401" mass="43761" checksum="E30B0303FC9420B0" modified="2019-05-08" version="1">MTNYSESSQRVHSPPSSFVGTSENFDSSSPSRQQWPRSHKLYILDPEPATACQPTPAIGCPIDHRIPRDPSTAQDIKSEPNNPDFRFIFELAPLSPPQETSCSPLVDVPVRAKWASPTMRTMMGAFRLDPFAMHDGHSMAVVAVPPIEVGPLTEEPVVVEFQVYLEHPLVPQSPEPDDQYTRDRMSMRDHSLSGHLLSPASSVHWDTYNALGDDRELLFGDTYFEYPPSPVASPCPLFASIMTPVQSLQWGVQYGADASVPFLTHWRIGGGRVSRASICSSNSNNSSGRDMTVGLTPSSPRNMSPHLPLPHPITRHLCIHTSPSLHPTSSLPTSSASSFASALGAPDGSLPASVENTWSRHRMMAECSRSSAGRRDGSLSGYLGCRPCPRSKQFGSTQQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H561</accession>
    <name>A0A401H561_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1602490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620499.1">
        <property type="nucleotide sequence ID" value="XM_027764698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H561"/>
    <dbReference type="GeneID" id="38786503"/>
    <dbReference type="InParanoid" id="A0A401H561"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="16392" checksum="81ECD9ABFD206E83" modified="2019-05-08" version="1">MDLANFERMTEEFAIYMNYVRKLGFEETPDYDFRLPPQDLYLGDIISRQLDFSTPCTLVSTAERGTKVHMYPAGRVTHTITQMSYRKNRKRRRSQAFPEDEENVIEQLPVVEVTPEQEQEPRGPEDAVDAADATSDKEREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5M8</accession>
    <name>A0A401H5M8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620661.1">
        <property type="nucleotide sequence ID" value="XM_027764860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5M8"/>
    <dbReference type="GeneID" id="38786665"/>
    <dbReference type="InParanoid" id="A0A401H5M8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="11577" checksum="BCEBAF87CF59FEBC" modified="2019-05-08" version="1">MLSADATLNDVNEYLTDDYMRHYQEKVESGPVRTAKAAWLISQQLIKTTSAPADSQAATADSTAVQPQASSQLQRHRAQPTPPPVEFLANSDDEPAPQERPKTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5R2</accession>
    <name>A0A401H5R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase citE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1700430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620632.1">
        <property type="nucleotide sequence ID" value="XM_027764831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5R2"/>
    <dbReference type="STRING" id="139825.A0A401H5R2"/>
    <dbReference type="GeneID" id="38786636"/>
    <dbReference type="InParanoid" id="A0A401H5R2"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="261" mass="28444" checksum="5E580699521731A8" modified="2019-05-08" version="1">MPHHSDAGSYFVPTTHHDTYPAIDPTKADLSGKVVLVTGASRGIGKTIAVAFTQAGASGLVLLARGDTEAVEAACLAAQRPGQSVMILPLAVDITNQTQVVMRPGSDPVDWWKVWEVNIRGTYNVSQAFIPLLIDCGGGKLIVSILAHQSMPALSTYQSSKFVVVRVTESIVADYGPQGIIAFAVHPCGTPTDMNAHVPPEIKKPFIDTPELAAHTMVWLVRERREWLSARYVSCEWDVEELLAKKEDIIEGDKLKFRMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H631</accession>
    <name>A0A401H631_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620810.1">
        <property type="nucleotide sequence ID" value="XM_027765009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H631"/>
    <dbReference type="FunCoup" id="A0A401H631">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H631"/>
    <dbReference type="GeneID" id="38786814"/>
    <dbReference type="InParanoid" id="A0A401H631"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF150">
        <property type="entry name" value="OXIDOREDUCTASE TDA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="479" mass="50628" checksum="AC17914FE5894754" modified="2019-05-08" version="1">MQNHMFSALPDGYPLTGKSGPLSPARLDVVIALRLSLQAHQSDLSTDRPARLTRDFPGAAVTMASPSDPATRNIVIIGGGIIGCTTAFYLVSHPLFAAESTRITLLEASEHGVAQGASGKAGGLVAKWAYPKELVNVSFPEHVRLAQEYNGAERWGWRFVGCGSWEGRGEAVSDDAGTGVGAGGKRKSLEKTVGLDADWSQKKREATGLPDDLLWVKAELTEAYSPMAPAKATAQVHPYLFTTSMLELAKQRGVEYISGKATAINVDKSTGRVSGVTYTDSALANQTIPATHVVLAAGAWSPKILPALPIVGTRAHSIAIRPQSSVTISPYVLFTEIQFRSSARGRLQQVSPEIYARPDNEVYCCGPGDDSAIPDTVDDVQVDQNACESIREHVASISNELREGTVDKRQACFLPIVGSGGGPIVGEATGIAKGLIIATGHTCWGISNAPGTAKALTELIMEGKISCANLAKLQPGVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6M2</accession>
    <name>A0A401H6M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1801200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621009.1">
        <property type="nucleotide sequence ID" value="XM_027765208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6M2"/>
    <dbReference type="STRING" id="139825.A0A401H6M2"/>
    <dbReference type="GeneID" id="38787013"/>
    <dbReference type="InParanoid" id="A0A401H6M2"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="231" mass="26539" checksum="02C8FC7AAEE254D3" modified="2019-05-08" version="1">MKEYQPLHMVNSPEEFIKVFTDVVHVHHWVSEISNILHRGISANNIMFYREGANIYGVISSIHESRGKQFNRYASKAPPTAGESSKQVKDGEMENVAAGPSQSRDKSKEDDQKKPRCLRIDIVTTSSRSSMFLRGFVRCFVPKPTFAAFANLDPEYRHLAYGPVKKLRRYFSVVNNLHWNNLVYICSQYTSAEEESDKEQMQNLFDDIMRRVEERNAAITYAGFMECLSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6S5</accession>
    <name>A0A401H6S5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1801590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621048.1">
        <property type="nucleotide sequence ID" value="XM_027765247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6S5"/>
    <dbReference type="GeneID" id="38787052"/>
    <dbReference type="InParanoid" id="A0A401H6S5"/>
    <dbReference type="OrthoDB" id="2756183at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019228220" evidence="2">
        <location>
            <begin position="30"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="604" mass="64588" checksum="1E015541FAB7F8BD" modified="2019-05-08" version="1">MSLIGVALTKVYQFLLHLWSLLTCRHTSSVEPDLELGIASPHARNDIPAVVPEGCANNLTHITDDLPAELNSSPAIENMPTNAVAIPSHSPAINFAIPKCVSLADLTTPQYWHLSALSSVAAIDRASRFPAPAPATPRSPSLHLDIADLSTISAASSSPPKTPTFADTLAAFPEPPPFATSDDFVLSSPRFIIRHLEVPSTPPYKDLSHVLPTGLTHSFSKLLSSSPGTPDKASAFASKLVTLIRPSTNVSTDTLPEQRPFDMDVDPFCMSGDSFFGDCGPVDLADMVLPHPNLYDLSVYATPSPRGLSKARSPSFRPARTTFIADISQTYAGRLTGDDAVLPLPPALEPMWGAPDVGGSSYLALGTRTLPIGAPRYRYSVVFPQLARASLSDTAPHHTPSTLLPAFESVTHAITSPVPEVLTVSSMATPETSSQAIEEEPPSSSPLQEAHSKEKEEETVATVADDAVHDASEAAENRRSRQLDDIVSLLDQLGVIGGDAQPADREHDAANVTLSDSTVLPVLERSASSSESTFSLPAGSLEDGFEEWEGEDFDEFVEPREHRMSRSIENLISLLEECRDSVPVTESHASAEDSENDHADAHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6Z6</accession>
    <name>A0A401H6Z6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box/WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1900080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621072.1">
        <property type="nucleotide sequence ID" value="XM_027765271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6Z6"/>
    <dbReference type="STRING" id="139825.A0A401H6Z6"/>
    <dbReference type="GeneID" id="38787076"/>
    <dbReference type="InParanoid" id="A0A401H6Z6"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="238"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="365"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE90159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="556" mass="62234" checksum="6FEEFD63E890245F" modified="2019-05-08" version="1">MIVVTDEGFTDAQDEAVHWRGGLDSAVVRETGTSIREREELAYSLLASLPRSSLAVVQRRIAPLLQLDVVGLLPDEVAIQVFSHLPYTSLLSCALVSRRWHTLTDDQTLWKRLCAQQNWEWRFPYKLDNHDDVCDYDDMDDEGMGDEEESEEAVAMLLDDSGFSSMLVDEIFTSPSFDRPMEKPRTSSCNRYPGSLSLNPVDRKKPDYKLLHQTHVHIRNRFLSGNYFLSYLQTRSTRDAHSNTIYCLQLYTYPDCGLQVLFTGSKDHTVREWNLSNGTVRRVIKGVHEGSVLSVCAHNGLLVSGGSDRRVVIWDLGRDVLRKVILDHEDSVLCVRFDDKRLVTCSKDRTVRTYTLPDFVPQHILGDHRAAVNAVSISSTHIVSASGDRSMRLWDAEKGTLLRTFENHHGRGIASIDYKPPFVLSGSSDKHLRLLDIASAQGWSTAPDAPGPTAAAPCQMCGSTVVRAADDVRRGHEDLVRSVALGEEFVVSGSYDFTVKVWDRKTGALVADLAGGHTGRIFCVGFDRAKIVSCGEDRKICIWDFAYGFDTSFIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4R7</accession>
    <name>A0A401G4R7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0100500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608091.1">
        <property type="nucleotide sequence ID" value="XM_027752290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4R7"/>
    <dbReference type="STRING" id="139825.A0A401G4R7"/>
    <dbReference type="GeneID" id="38774095"/>
    <dbReference type="InParanoid" id="A0A401G4R7"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="71732" checksum="EEE00BA8E19BD91D" modified="2019-05-08" version="1">MRFPLSLKSLDFLISRLTAPPNGRPCYISNLSHDTLVDQIFIYLDVFDILRLRLVNKLYYYLTHHTAIWKRFLQNAEVPLPLLPPTSRYSLQNINGLEAERVVLRGVSLEERWKSGNLDYMFSWEFYAHHHILSMAMLPGGHYIVASVTNNARSQYSLIIFVVDSTLAGAWVVARTDTITKAYHVQAKYMTIGDERGIVVAYIRRNYRRFKDMWSGVDISQYSADHEIDPPVPIKYECVCLHVPLSSLEILGDSRIVPGSEDYLRHAKAQPAPFRPLATVQTRSPLGIPSLDEIFGSPYLAVAKDRNKIVFKKLDGGPATTLHCDATLEGPIEEHSIAAIRLISAGNKVLVARKVSQGVPMVTLEYYDVIPPGDEKAEVHATFTSAIRIRNTDAMYVKISDHGIPPREDNSVVPSLYGRPEAYAPRPISVFMCTKGGSVLKRLTIFPVRNQDVPLPSPSSGPLSHEQTYGAYTYPLTEVNRIVTRSCQGEDLEFRVLAGSYRSIVYTTPQGYRRDAPPIVDFYRYFDPLSRWKDPPEGTNDHRDDIVSQTFVPNSVKDMKSVTALAWDETIGRLCIAGEGSLMVNVLDFAAWPLSEETSEGTVRWPVPVYLDPDPDVILAPLPELPPEEDGGMDQLDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G540</accession>
    <name>A0A401G540_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0101470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608187.1">
        <property type="nucleotide sequence ID" value="XM_027752386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G540"/>
    <dbReference type="STRING" id="139825.A0A401G540"/>
    <dbReference type="GeneID" id="38774191"/>
    <dbReference type="InParanoid" id="A0A401G540"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="608" mass="62740" checksum="DC3F908806DEDBA9" modified="2019-05-08" version="1">MYPLRSNCNMIVDDDDEFLYGNSADIPEVKTPVATSVPQPISLEETRSTAQGLVATLEEKAASSSNGTPEVAANANGEDAEGEAEGGGEVEGEAEEEEESDDDIEIIMDQPSRSLDLRQQHRPGNRPTNAPQGTPTRGPQQPQLSLTTEYTPRERGGVTKISSTPQPTGTTPVLGDIGETPSAVQKTPEGTQQAESGPDTSTLPVAKAPPSHPSINPELPGTLDGRSILEVDLSALADKPWRRPGSDISDWFNYGFDEISWEAYCYRRREIGDVASVLKNNMLSFSGMAEDQLTALPPEIRTMVMAGAMMAGGGAPGGGGMMAPGGGMNMNGGAMMNQMMNMGGMMNPMMHEMGGVVGPGMGMNGDMGMGMGGPGMQMGGGQGMPAQGMGGGPGGGMMQDGTSQGGMGGGQSGGQGTPEQQMAMGDGFGPGVSGAGQGMIGIGMGGEYTMQDQNAMGQQMGQQMGQQMGQQMGQQMYPGMEGSATPVPAAPTPTRGVNAPAPGQFRGRAMQAGLGGMRGRGGFAARGRAVPVRPASPLPPNVPTGPRNKNKYKDIDGSAPAVDGLDYGGGAGGMKEATRGTPDQDERSSSRKRRSSPGLDEGRGSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5B0</accession>
    <name>A0A401G5B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0102290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608269.1">
        <property type="nucleotide sequence ID" value="XM_027752468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5B0"/>
    <dbReference type="GeneID" id="38774273"/>
    <dbReference type="InParanoid" id="A0A401G5B0"/>
    <dbReference type="OrthoDB" id="3358750at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39475:SF1">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="114" mass="12759" checksum="6712CE0B36D70DDB" modified="2019-05-08" version="1">MQPKVGNPQVYDDGDQRRNAPRGADAPAPFEAGKRNAHDIHDPKDNRTLGNRQKQEEKAEHDRDLELESHTVTDPLEPAQSQGHKPSRGAQVDAELQQEDEEMLKKKGCPKDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5C9</accession>
    <name>A0A401G5C9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0102490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608289.1">
        <property type="nucleotide sequence ID" value="XM_027752488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5C9"/>
    <dbReference type="STRING" id="139825.A0A401G5C9"/>
    <dbReference type="GeneID" id="38774293"/>
    <dbReference type="InParanoid" id="A0A401G5C9"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019525038" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="181"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="450" mass="50278" checksum="73F4181A4314DFCB" modified="2019-05-08" version="1">MSVIFWRIVSFWLLSLPVIFALPPAGLQPQIPSVAFFTPGQGTFELLPDVRIIVDAEHGLEGSPSAYSFGETFRTDLMGVAGYNYISPVALSDYSVGTVSTPVIYILIDPTFNFTLYNGKPTPEGYNFEVTEYTYTITASAPIGAWWGTRTLLQQTALNFANDFQTITLPAGTGSDSPGWEIRGFMLDAGRHWFDSTFLADLCVYASFFKINEFHVHASDNLWNPDYLYGSGDSWKELYAAFRFQARPGSSVEGLDQRVNESWTQSEYSAMQEICTNHGVTIIPEIDTPGHSLVITQWKPELMLSGSPDMLNLSYPETIPTIQTIWKEFLPWFTSPEVSIGADEYVASLGDEYTAFVNEMSDYIYAESGKSIRIWGTLEPSSTPISHNVTIQHWDFPDEDIPVQLMEKGYYIINSEQCFLYLDGKTSSYGQFPQTLDLTLMFSGAPDGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5E6</accession>
    <name>A0A401G5E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0102530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608293.1">
        <property type="nucleotide sequence ID" value="XM_027752492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5E6"/>
    <dbReference type="GeneID" id="38774297"/>
    <dbReference type="InParanoid" id="A0A401G5E6"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11505" checksum="ED7DD1FD47F6A9C3" modified="2019-05-08" version="1">MGHSTKLLTPTQTVGDIFSDEFRQKLPAKLTNVLAQSGVGPIILWGECAMLYYGVPVSQNHMHLLVPDDQLETAYKVLLAAGYKDSPLPLIPIVSSRDPNTRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5J5</accession>
    <name>A0A401G5J5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0102980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608337.1">
        <property type="nucleotide sequence ID" value="XM_027752536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5J5"/>
    <dbReference type="GeneID" id="38774341"/>
    <dbReference type="InParanoid" id="A0A401G5J5"/>
    <dbReference type="OrthoDB" id="3253465at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="93" mass="10812" checksum="8CD36D91CEDC6DE5" modified="2019-05-08" version="1">MCQCLITVMASTHALSMGAINLKVHERGLYPHIGDIEMYKEAGMLSTLRMKFHLKVFKNNMETTGHEQDLWFDPVLFAHNIPFENSLWMFCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5W6</accession>
    <name>A0A401G5W6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calmodulin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0104360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608471.1">
        <property type="nucleotide sequence ID" value="XM_027752670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5W6"/>
    <dbReference type="FunCoup" id="A0A401G5W6">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5W6"/>
    <dbReference type="GeneID" id="38774475"/>
    <dbReference type="InParanoid" id="A0A401G5W6"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23788" checksum="E45BB7A7E906EF60" modified="2019-05-08" version="1">MSRYPSHLSPDITPTSTPVKSKSQRSRQRREPSGVFSLFSPPQVQQFREAFSLIDHDGNGVVSEQDLKHIFSSLGITPSKSMVDDLLAERPGARRGSALHSRLPSLEADAASDRGITFPMFLTMMGEHLYDFDTETELLEAFECFDEGDTGMVKCNEVRRWLGDVGERMDEKEIDKLLKGPFTDRQGNFNYREWVKVLRIDADDQAEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Q8</accession>
    <name>A0A401G6Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase SPB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0107340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608765.1">
        <property type="nucleotide sequence ID" value="XM_027752964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6Q8"/>
    <dbReference type="FunCoup" id="A0A401G6Q8">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6Q8"/>
    <dbReference type="GeneID" id="38774769"/>
    <dbReference type="InParanoid" id="A0A401G6Q8"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="245"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="649"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="501"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="619"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="859"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE77852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="875" mass="99250" checksum="7B532989A6CFE162" modified="2019-05-08" version="1">MGKAQKKTGKGRLDKYYKLAKEQGYRARSAFKLIQLNKKYSFLESARCCIDLCAAPGGWLQVASKYMPVNSVIVGVDLVPIKPIPRVVTFASDITTPQCRNLIRNELKDWKADVVLHDGAPNVGTAWVQDAYSQSELVLMSMKLAAEFLVKGGTFVTKVFRSADYNNLIWVFKQLFGRVEATKPPSSRIVSAEIFVVCRDFLAPKQIDPKFFDPKHVFKDLSTSLPADDDKGTSSKNYQANVFQPEKKRRNRDGYNDGDYILFKKSGAAEFVRSQEPIAFLGSVNKITFETNEEKEWLMLDVTTPDVVANCDDLKVLGKGDFKTLVKWRTALREELGLEVKTKPTEEVTEIVEIVEEVDQEEEIQNELERLHAEAAARTKRERRRANEIRTRTIQRMQLQMTAPLDIGLEQSDAALRDGQEDIFDLNDATKLLRSKGGIKGFVNGEDADSESNSEVLGEDEDNELWDSEDERDKKVTELEAELDGMYDAYRDRLRELDAKYKVKEARKNNKEREEWQGIRQDDGDEGDSDEGSGDEGGYERIETARARAGEDSSSDESDEETEEGYNVGRLKRRRGEESDFTAPESKRARTIVKLDESKSHLSQVAKVWFSQTCFTGAEDDMAESEDEDVMDEDKELVPDDERRDEVDSSDDNDFEVVPQDDDDDADMWDVENGNEDGIRQAQIQKQGLLSAEAVTIAQQLVNREKTRTQLINDGFNRYSLNAKDGLPSWFLDDEEKHYKANIPVTKEAVAALRAKMRALDARPIKKIAEAKARKKFKAAQRLEKAMKKAEGVNATADMTEREKAKQIEKLMQKGMSTKKQKKEVKVVVAKGAHKGLKGRPKGIKGRYVMVDSRMKKEVRAKKRQEKASKKRKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6S5</accession>
    <name>A0A401G6S5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0107520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608783.1">
        <property type="nucleotide sequence ID" value="XM_027752982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6S5"/>
    <dbReference type="FunCoup" id="A0A401G6S5">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6S5"/>
    <dbReference type="GeneID" id="38774787"/>
    <dbReference type="InParanoid" id="A0A401G6S5"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="278"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE77870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="531" mass="57227" checksum="D450197C436A1EAC" modified="2019-05-08" version="1">MGHGNSNKLYVTHAEHSGLFGQHTASSAGFKAKNQGPPPSASTPFDCCALSLQPFTHPVCARNSDGTGFVFDLVNIIPWLKQHKNTNPITKEPLVPEDLITLHYAHKPTGEIHDPISFKPFSEHSHIVAIASTGNVFLAESIKGGRDLVADVKFKKEEVIILQNPHGLPSASVAAPAAKTTSSEQTKTVATKPSASASTAPTVKKAPVPWNISPYSTGLPGASLTSTSVDPQTASSQLAWDEEELMFDDFANPPKGKGKEKDLGRRRAYVRVVTSLGGSLNMELFCEKAPKTCYNFLQLAKAGKYNDCLFHRLVPGFMIQTGDPTGTGSGGTSCWGTPFRDEYDMRNAAKHDARGTVAMANKGSGTNGSQFYITFRETPNLDKKHTVFGKLVGGEEVLDTLESIPVKPGTDRPVKSVRITEVVIHQDPFEEYKTRQQKKIARRAEAEQNARTGKVVEKKDGDDVNWFGIKVGLESTAVGGNSGGGVGKYLGSGGGTKRAASHQPLISTLDPEVPEEGKKRRKIGFGDFEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6V1</accession>
    <name>A0A401G6V1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0107780</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608809.1">
        <property type="nucleotide sequence ID" value="XM_027753008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6V1"/>
    <dbReference type="FunCoup" id="A0A401G6V1">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6V1"/>
    <dbReference type="GeneID" id="38774813"/>
    <dbReference type="InParanoid" id="A0A401G6V1"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="256"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="130"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE77896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="32665" checksum="FC5B85181BBD4A85" modified="2019-05-08" version="1">MATPERQELIRNAVAFLADPKMLSSSLSQRVQFLEAKGLSSAEIDEAMRQAALNQSGPRVPAQSYPSAYPPVYGPAPYAIQPPLERWDWRDYFITAVVSGSVAYGAISLFNKYVLPHLQPPSVTAYEADRDALTAQFDAAEALLKEIQEEAAAVRVAVEEQNAKVEKATQDVEHVVKDMREGEMKTRDEMREIREEVNNVREMLPKMMEKNKESQAQSMAELQQELKSLKALLLSRGPSAPSGLSTPILPGKPSIPAWQLAGASPNGGLGGSSSLPSSPGSAAPSLVVPNGKGKEVDVPLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Y7</accession>
    <name>A0A401G6Y7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0108070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608838.1">
        <property type="nucleotide sequence ID" value="XM_027753037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6Y7"/>
    <dbReference type="FunCoup" id="A0A401G6Y7">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6Y7"/>
    <dbReference type="GeneID" id="38774842"/>
    <dbReference type="InParanoid" id="A0A401G6Y7"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="45"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="366" mass="40095" checksum="C8C2E3DE538600D7" modified="2019-05-08" version="1">MPGRVRKRSPLKVPDRPYIALGLEGSANKLGAGIIRHGPDGSTTVLSNVRHTYITPPGEGFLPRDTAIHHREWALAVINDALNKAEISFHDIDCICYTKGPGMGAPLVSVALVARTLSLLYDKPLVGVNHCVGHIEMGRQITGARNPIVLYVSGGNTQVIAYSQQCYRIFGETLDIAVGNCLDRFARVIDLSNDPSPGYNIEQEAKKGKRLLSLPYTTKGMDISLSGILTSVESYTRDKRYRQNGPLSEGEVDIITPQDLCFSLQEVVYAMLVEITERAMAHIGSKEVLIVGGVGCNEHLQGMMGTMAKERGGQVFATDERFCIDNGIMIAQAGLLSYRMGFQTPLTKSTCTQRFRTDEVHVAWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Z6</accession>
    <name>A0A401G6Z6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0108160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608847.1">
        <property type="nucleotide sequence ID" value="XM_027753046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6Z6"/>
    <dbReference type="GeneID" id="38774851"/>
    <dbReference type="InParanoid" id="A0A401G6Z6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="33442" checksum="5294013D25AB6F10" modified="2019-05-08" version="1">MDSIDTHVLTVAPDTHAQENDALHSARGTQQDQEDAIVAGAEHAMIAQRALPALHLDTALNDVLTSIPLSFIDDSVYSIENTRVDRTDGPPSLIDMRPTGFVFLSHLDLADISATPPLSRSPSPEYTPSSPVYIPLSPVLSSPPSPPSSACACTHEADCHAMRACNRPLLLPRSTLPVTHDPDTRICRPTHPPSSHARCTSPDSYDGDDDLPGLVSVSRGNDSSDSESDMDLKDDTDDDDNHLQSECEREDLMHKCVEEILVEAMRDVTEEVVEYGAGPPIKHYAPFSFIFSYSRSFIAKYTQSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G812</accession>
    <name>A0A401G812_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0111960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609224.1">
        <property type="nucleotide sequence ID" value="XM_027753423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G812"/>
    <dbReference type="GeneID" id="38775228"/>
    <dbReference type="InParanoid" id="A0A401G812"/>
    <dbReference type="OrthoDB" id="2684181at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="26656" checksum="E37B992A1B42FE42" modified="2019-05-08" version="1">MPPRISSKPSQQDDQRDGAFVKDMTERYTNYLVIAETCGRTVRGMGYGEDDADRVRPVYDQVVRDWYNDPTTIILRTNSAEPNEQAAFFRQCDEICATPLDSPYKCFWVGFAATAGAQGLRSLFSKHPAKSKILREASDESIQRLIGEQGFQQLANLASSLNPQQIENASSLAPRTMDPMEHIGETIRYKDENNSIVECTIEDAGTSIVKGDFFKLSDPGGGQKEVSSEEMARILRNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8G0</accession>
    <name>A0A401G8G0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0113440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609368.1">
        <property type="nucleotide sequence ID" value="XM_027753567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8G0"/>
    <dbReference type="STRING" id="139825.A0A401G8G0"/>
    <dbReference type="GeneID" id="38775372"/>
    <dbReference type="InParanoid" id="A0A401G8G0"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="67"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="513" mass="54980" checksum="E3663D18229D6D20" modified="2019-05-08" version="1">MGGDGLARRSARVPPSPSPSPTFSTPSSSSCDMASSQEPSIVPLLSRALHHIRLTPPRVIASPATQPRRAAVALIVRVVPPPSYAPRPVSAAQPDPVAAADPSAPSSSPTNVPTPSLSEFFELDWVKAPGARPEILFLRRDTPDSGDAGRLSGSGPRTREAHVAFPGGKTEESDEGGLYTAMRQTWEEIGLDLAESAYTPIGQLDDREVTTSLGKRLLMVLSPFVFLQLAPQTTAVDPVAGTTLHWVPIAELLPLGGDGEPRPRWSSVSVDASSRLAPRHSTLLRLLMRILVGSMQFPAILISPSSSSASLSPSPSKDTAKAIDAKRAHVEAGAANGTLRKRNSLPGLSRVRELERTQLKLWGLSLGMTLDLLVHMASDVGSIPASKGKKKRRRSVKDRALVALNASELLPPDALMAMGVPVVAPSLASVFPRFSYPDVNFWIWVFAKRYRAVIRGWEASARAGGTNDRRMNWTGSALTTFYAAVRKALVVVLVLRALGVLVALVLGTWILFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8L4</accession>
    <name>A0A401G8L4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CCA tRNA nucleotidyltransferase, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0113930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609417.1">
        <property type="nucleotide sequence ID" value="XM_027753616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8L4"/>
    <dbReference type="FunCoup" id="A0A401G8L4">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8L4"/>
    <dbReference type="GeneID" id="38775421"/>
    <dbReference type="InParanoid" id="A0A401G8L4"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="555" mass="61687" checksum="260A2E5D07C22B29" modified="2019-05-08" version="1">MEIKLTEAEDELCTLLDECTRRIKEKKGLETTCRIAGGWVRDKLLGHQSHDIDIALQDMMGMTFAEHFVTYCRSVKHISVKNIAKIESNPDQSKHLETAKTTVLDLELDFVNLRSEEYAEHSRIPTQVAFGTPLQDALRRDITINALFYNVHSRVVEDHTGKGLDDMRSGTIRTPLPPKETFSDDPLRVIRCIRFASRYGFDMVPELQEAAQDPEIQEALASKISRERVGEELDKMMRGRDPLHAIKLIKDLSLFSSIFHIPQNIAVTLSARPAPQDTALAAASYLYAFLNPTLPNLSSIVPLSFPPLHHLLLSGTASEPSPISRLYLACALTPYRGVTCLDSKDKIQLAVEPAIREGLKLGVQHHYLDGIPTLFAAVDKLGNAVVGKGHEQPAAQWDRAAIGLLLREKVVHNPNIGSTWSISLLFSLVQELVPLWDIERDEFDAEEATKRVIAYNELVARIEELKLPAAVDAKPILDGRTVMRTLGTATPGPWTGDVLSRVVEWQLRHPEGSTDECQNWLISEKAAGRINIVTNTSGSKRKDGSGGKSAKKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8N2</accession>
    <name>A0A401G8N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0114140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609438.1">
        <property type="nucleotide sequence ID" value="XM_027753637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8N2"/>
    <dbReference type="FunCoup" id="A0A401G8N2">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8N2"/>
    <dbReference type="GeneID" id="38775442"/>
    <dbReference type="InParanoid" id="A0A401G8N2"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="538" mass="59783" checksum="E1A14320DAA1BFA1" modified="2019-05-08" version="1">MPPKALSTSLESIQILPRTPKTPRSGHHRWTPSDGQLDEVELSLLDEDERREAGNGVAVGESLLSVKHPVQDTSAMVLLVILYLIQGFPLGLALGSIPFILREHLSYSQLAVFSLSSYPYSLKLLWSPIVDSMFFRSFGRRKSWIIPMQLIIGTIMLALSFRAEEMMEHPAEHLYELTAAFTGLVLFSATQDIAVDGWALTLLSEENLPYAATCQTIGLNSGYLLSYTVFLALNSEAFAEKWHIPRLTLSGYLLFCSAASFLVTIWLLFKREGKETSDEDISIKSVYLDMWTICKLRHVQTLLIVHLFAKIGFQANDAVSQLKMVEKGLGREDLAVTVLIDFPFQIFGGWLAGRWSRGEKPLRAWTYAYWPRLTLTLTATLIVYYFPKPPISTGFFIVLIVQTVAGSFSSTIQFGGISAFHTRISDPVVGGTYMTLLNTFSNLGGTWPKFFVLKGVDFFSIATCKIGHDLSVKAAECVSEHGKTSCAELGGECVTEQDGYYIVSGICLGLGLLSVISYMIPTARRLQAIPVSKWRVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8P7</accession>
    <name>A0A401G8P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0114390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609463.1">
        <property type="nucleotide sequence ID" value="XM_027753662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8P7"/>
    <dbReference type="FunCoup" id="A0A401G8P7">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8P7"/>
    <dbReference type="GeneID" id="38775467"/>
    <dbReference type="InParanoid" id="A0A401G8P7"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="241" mass="27252" checksum="292D16A28524BA9E" modified="2019-05-08" version="1">MDRIAVELAEYLAQFLQSTDPSARLLVGIAGVPASGKSTLVQHIVDYLNDTLPLGNEPSRTDDTTRKDVAVSVGLDGWHLTRAQLDALPDPKLAHDRRGAHWTFDAVAYVDFVRVLRQPRSEEVIYAPTFSHVIKDPTPYAVPVFAHNRIVLIEGLYTFLGITPWRTAAEMLDERWWIDVSEEEAQKRLVARHVESGVAKDLEEAMWRSRENDAPNGRFIKENMLKPTKIIHSVEDPRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9P0</accession>
    <name>A0A401G9P0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0200680</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609784.1">
        <property type="nucleotide sequence ID" value="XM_027753983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9P0"/>
    <dbReference type="FunCoup" id="A0A401G9P0">
        <property type="interactions" value="699"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9P0"/>
    <dbReference type="GeneID" id="38775788"/>
    <dbReference type="InParanoid" id="A0A401G9P0"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="80"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE78871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="472" mass="50378" checksum="525F26ADED6A13B4" modified="2019-05-08" version="1">MSFAKVASSSSTPVAHNALPPPPTASAARSSRIAPHSHIKGLGLTAEGYIAGDAGGFIGQALAREACGVVVELVKTKKFSGRALLLAGAPGTGKTALALAISQELGAKVPFCPMVGSEVYSTEVKKTEVLAEAFRRAIGLRIKETKDVYEGEVTELTPTESENPLSGYGKTVSHVVVGLKTVKGTKQLRLDPTIYEAILKEKIVVGDVIYVEHNTGAVKRVGRSDAYASSYDLESETYVPLPKGEVHKRKELVQDVTLGDLDAANARPQGGQDIMSVMGSLVRSGRTEVTEKLRREVNKVVKGYVDQGVAEVVPGVVFIDEVHMLDIECFTYLNALLESPMAPTVIFATNRGNAVIRGTTDIVSPHGIPLDLLDRCLIVKTPGYEREEIAKVIQLRANFEGFTLGSGVLEKLAERGSNSSLRYALQLLAPASILAGLAGRKQIELEDINEMAELFLDAKASAEIISMGNNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAJ0</accession>
    <name>A0A401GAJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial peroxiredoxin PRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0203640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610080.1">
        <property type="nucleotide sequence ID" value="XM_027754279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAJ0"/>
    <dbReference type="STRING" id="139825.A0A401GAJ0"/>
    <dbReference type="GeneID" id="38776084"/>
    <dbReference type="InParanoid" id="A0A401GAJ0"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="4"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="222" mass="25250" checksum="3ADFB8CC57C6A21B" modified="2019-05-08" version="1">MPSLRLGNTAPDFEAETTQGHIKFHEWIGDSWAILFSHPGDFTPVCTTELGEVARRIPDFRQRNVKVIGISANGLEEHEKWVQDINEYGSKFAPTNVDFPIIADPERKISTLYDMLDEQDATNRDAKGLPFTIRTVFVIDPKKVIRLTLAYPASTGRNFDEILRVVDSLQIGDKYRVTTPVNWNKGDDVIVHPSVTNEEAKTLFPDFVIHKPYLRTTPLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAP6</accession>
    <name>A0A401GAP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0204370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610153.1">
        <property type="nucleotide sequence ID" value="XM_027754352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAP6"/>
    <dbReference type="FunCoup" id="A0A401GAP6">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAP6"/>
    <dbReference type="GeneID" id="38776157"/>
    <dbReference type="InParanoid" id="A0A401GAP6"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE79240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="817" mass="89323" checksum="1DDA80E60106C562" modified="2019-05-08" version="1">MASASVAYISASTNRHSHAADASTSSLIAFGCAKLVALWDVQDEYDRGVYETLPGHEGLVTCVRFIQDDRFVSADDKGVMRLWTKKGTQWKSSCVTQAHQKAVSALAALDEIVVTGASDSSVKVWSLASRNESDAFDEVQTIPLRGEYPLSLAVSTLPQTQATILAIGGTDRHIQIWTRSEDLFVSSVVLSGHEDWIKGLAFRQPVLDDQPLILASGSQDATIRLWNVEPFTKKPTEATPSAPENDLSGELLDAFEVSLGDLTDAEEGGRQISLKRHILTVKSQNGALQYSITFDALLVGHEAGVTSLSWRPRSPSTSVPTLLSTSTDSSLILWSPSTIITPTTDGSSSIWINRQRFGDVGGQRLGGFVGGLWTCGGFEASAWGWSGGWRRWRCSATDENAESGVPSNHNEDWGEVGAISGHNAAVRGLSWSPNGEYLISAGLDQTTRIHGEVRTSDKDGSSVPVWHELARPQVHGYDLVGVAFIDALRFVSIADEKVARVFEAPREFVDVINNLGTAHFGVEENERPRAATVPPLGLSNKAVSEVNSQSERLNDWHDADRTRRRPFEGELAAITLWPEIEKVFGHGYESIALAVSSSKKLTATACKATSPEHAVIRVYDTDKWQPMGLPLAGHALTVTQIAFSPDDRFILSVSRDRSWRLFERNGEDGYAPITADKSHSRIIWDCAWAHEGDIFATASRDKTVKIWHPKDTSSWDKWTAVATIKTKEAATAIGFSTVNADNRRRLAVGLESGGILIYSSAEADATEWRLDLTMNSCIAHVDQIHRLIWRPYSDNLELASCSEDSTLKILTVRITTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAV4</accession>
    <name>A0A401GAV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0204710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610186.1">
        <property type="nucleotide sequence ID" value="XM_027754385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAV4"/>
    <dbReference type="STRING" id="139825.A0A401GAV4"/>
    <dbReference type="GeneID" id="38776190"/>
    <dbReference type="InParanoid" id="A0A401GAV4"/>
    <dbReference type="OrthoDB" id="3147752at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="429" mass="48517" checksum="82026B2185307251" modified="2019-05-08" version="1">MPILDDAYDMIQSVIAQITTIDARSFTTTDLEIYNLKKQLERLRAETEFYKKETQKLRGHAHRSAVEIQATGERLYGAKCEIRRLQTCQEETEAAHQQVVQDSDSKTHELIALQKKHHAIEALLRIHSVELQDAQQYLSKVDNVPDADVLHAIQKVNAEVFHMAAQLAESLKFDNHCPVDFCNQLEEGTQLEGRLGLTLVQSRKCLGHQDDPICVQIALQGCMTMFSNWVIETWDFLNYTDKGPFGNVYASLNEKETQNVAGRWRVLTRSHIKSLLPKEPEVARRLQNLLIYNISEVLHTAGLRQRPQEMEEALERIHGEQMGSVIRLCLGLRTATGEHILSRDIETLVVEPGVSFDVEQMQDAFNGVDIEKGRTAVLCVTELGLRCVEKDGNGKMHRTTLLKPKVALETMVRELGELGFSDLKISGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB23</accession>
    <name>A0A401GB23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0205630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610278.1">
        <property type="nucleotide sequence ID" value="XM_027754477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB23"/>
    <dbReference type="STRING" id="139825.A0A401GB23"/>
    <dbReference type="GeneID" id="38776282"/>
    <dbReference type="InParanoid" id="A0A401GB23"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="229" mass="24137" checksum="E7D7F52B58811A99" modified="2019-05-08" version="1">MFNGFHTPIPPSDAEIATQTLNEESSCRFHSFTANDAVTLGLSLRKRFRSSSRHAKGKGLVISIQTIAGHTLFACTVGDLGGVSGVGDVSLDSWACLEGMIAVVRRTGHSSYYVEKGMGAVGKTPTQLGVKGEYRISGGAFPIWLENAPCCPIAVVACYSGSSPDDHHLVAIAVRDYVKKMLKGSGAPPPPSVPMPVLPSAGRQSFEWIAEPASSGLHGTAEDQDEHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBN3</accession>
    <name>A0A401GBN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0207570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610470.1">
        <property type="nucleotide sequence ID" value="XM_027754669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBN3"/>
    <dbReference type="GeneID" id="38776474"/>
    <dbReference type="InParanoid" id="A0A401GBN3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="368" mass="40943" checksum="3D0EE784A88EB7F3" modified="2019-05-08" version="1">MPNINDIAIEVSSWKMNIVLGLSGYSPPPVPPTQPPTLPQFSATLALKPTVFTVITRTNHGTLRHRPAFGLVRGQYRNDADVITQEFISEQYLTTLPRSYITQYDVFTSRPHAHYSRSRPGTFARSAKQALVIFSPSSGYHGWYHCRSILEQERVDELTDMLSVCTLHDYPCDDPHLVEGICHGLASLTISDPLVIIKNAASSCEEVDQLARRVALLRIIDDFADAVDCMGASFDSDLTLVECPGATMESEIFKTVHIATADTAELGVLDFEPDKERLWTENTMWKPPFSSIDADQHNKTERLSLDDPIFPSSCLSCTRMLAHALPHILPSALSPLTSTEVLETLHRVARPDLFFPLPPMVSLLIDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC60</accession>
    <name>A0A401GC60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sphingosine N-acyltransferase lac1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0209140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610626.1">
        <property type="nucleotide sequence ID" value="XM_027754825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC60"/>
    <dbReference type="FunCoup" id="A0A401GC60">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC60"/>
    <dbReference type="GeneID" id="38776630"/>
    <dbReference type="InParanoid" id="A0A401GC60"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="201"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="451" mass="52341" checksum="FA88D03FBD2253D6" modified="2019-05-08" version="1">MPAEPGTQFAISHFPAWVSFFRSSTSMAPSLSLRQRALEQSLQIETKDTHHLTGPFRPQTPLDAQFPESPTMAQKGANGHIPAAFDRWSTASQGFGADIMSMRWIVVPSSSLKIIIASIVLWANWEILAPYVGDLPNPFAPLLFISYRIPDSSPDDPRYSKGILDFVFVSYYIVVFSFVRQFITLQVSRPVAQWFGIKRESKLARFGEQGYALVYFAVMGAWGARIMSQSPIWWYDTKNFWLGYPHWDMKPELKRYYLMQAAYWCQQLIVLLLNLEKPRKDYTELVAHHLVTLWLVGWSYVCNMTQIGNAVYLSMDVPDTFLAFSKLLNYIQWEYTKVVTFVVFVGVWSYFRIFLNMVMLWSVWTEYDLIPLASQRFWPPDGVWMVWWMKYQVFIPIFLLLCLNLFWYFLILRIAYRVAGPTQGITDVRSDDEDDGGDDGKDDGEDDDKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCU4</accession>
    <name>A0A401GCU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0212010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610912.1">
        <property type="nucleotide sequence ID" value="XM_027755111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCU4"/>
    <dbReference type="STRING" id="139825.A0A401GCU4"/>
    <dbReference type="GeneID" id="38776916"/>
    <dbReference type="InParanoid" id="A0A401GCU4"/>
    <dbReference type="OrthoDB" id="3263038at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="258" mass="27844" checksum="D1AD458CE7E2B45B" modified="2019-05-08" version="1">MLMQQRAAAMFSTTPSTTAVWSQINLDKEKPLLDAETLMALVLEKWDRRKMLKGAMPKAKDLSVAASMVLSEKPKGGKGKGLRKPVGVCWNCGGKRHKEADCPTPKQGSKDKDKGSKSAEPSKSTSKPIAVSAVTLDDIAGAWSAFIPADFSDDSVSSVLDLWSVSDDNSDYSALTEASTDNVEMPDLVSVSNSSASEFDDESASDAQSCDVGDAISHEDGLKVARAHKAARHIRKTQLSLKRTLNCLKQTYSSYLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD66</accession>
    <name>A0A401GD66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0213320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611042.1">
        <property type="nucleotide sequence ID" value="XM_027755241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD66"/>
    <dbReference type="GeneID" id="38777046"/>
    <dbReference type="InParanoid" id="A0A401GD66"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="9456" checksum="405596A54857D8C6" modified="2019-05-08" version="1">MVPTGDRSDSEAPHTRFELSFAHNLPERFFSTFELVGNVYSKSWNRAEGVHAHICHSATVTWTNRILRKDARTYRFWMFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD92</accession>
    <name>A0A401GD92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0213350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611045.1">
        <property type="nucleotide sequence ID" value="XM_027755244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD92"/>
    <dbReference type="STRING" id="139825.A0A401GD92"/>
    <dbReference type="GeneID" id="38777049"/>
    <dbReference type="InParanoid" id="A0A401GD92"/>
    <dbReference type="OrthoDB" id="3232309at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="491" mass="53762" checksum="A96523DCF31EC47A" modified="2019-05-08" version="1">MSNRNSNRRTTYAAVLQRYAANFNVKLLADITLAHVLAGDTCAPISLSDFEAYLAHKEHTLEHLQFVVWFQDYRARFLALPEEIQAASPGPKQFTFALPTPARTAQRVAATSTDGRVPSTPFPGLPTVTEQPFRDECERIVATFLHPGAPKELPLEPALRDTLLRALSWNTHPDAFLPAYEELYALVEGVSLPRFLVAASANINLPKQLYWYGVGFVDLVVSILITLLLVMLVPAPPEASRAWRLFAVPFAALGSMQTYSAWRGFCSQVWGRGATQLRVWEMHEMDDEAAAHWARALDPLPSPTLSPSSPTSPTMGGVQMRERAGAPVWDSQQSTLASGCPSMKASSSPGTSTTMSMCLGREDDMDLDAIAPFGSPEDKDKDGTLVRVGSASSQPSLARTRCPPRLRIQPSSLSIKSAVDSGAPPAFSLADERDDEDGGFSRPPVFGPEKVVLDPRIQAVHRRVMRDILWVGFAWTAMFTAIVLAVPARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFU0</accession>
    <name>A0A401GFU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0307710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611961.1">
        <property type="nucleotide sequence ID" value="XM_027756160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFU0"/>
    <dbReference type="STRING" id="139825.A0A401GFU0"/>
    <dbReference type="GeneID" id="38777965"/>
    <dbReference type="InParanoid" id="A0A401GFU0"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="735" mass="77950" checksum="2B91428249F73976" modified="2019-05-08" version="1">MPTKINGAVHQPLASPLVSRKGSQAHTATLVDAHVEPEHSSAPTLLAKFIEAQKELHAFKSGQAVVVDGCALSIPAVTAAARYGAQVVLDNSRPIKERVAKSRAVIVHKVASESSVYGVSTGFGGSADTRTDDPLALGHALLQHQQCGVLPSQTHSAPLVLPLLDPLTSTSMPESWVRGAILIRMNSLIRGHSGVRWELIEKMGALLQENITPLVPLRGSISASGDLSPLSYIAGVLIGNPSIRVFDGTARFGSRHIVSSAQALAAHGIEPIPLSSKEHLGILNGTAFSASVAALALHDAVHLALLSEVCTAMGTEAMLGAQGSFAPFIHAVARPHPGQVEAAAIINDLLTGTQLAVTHEEEKLITDDVGELRQDRYPLRTAAQFLGPQIEDIMSALSAITLECNSTTDNPLIDGEAGTVHHGGNFQAMAVTNAMEKTRLALHHIGKLLFAQCTELMNPSMNRGLPPNLAATDPSLNYHTKGIDIHLAAYVGELGYLANPVSTHIQSAEMHNQAVNSLALISGRATINSLEVLSLLTASYLYALCQALDLRALQNELEAGMQKIVQAQLSKHFAAHLAAVDLEKLFAAIWLAMDYVLAGTSTTDAAPRMRKVAAASTTPIVDYCLTHGAAEALVQIPEFRKSVADQSEKLLEQLRVAYLTGERGAAPASPLLGKTRPVYEFVRVTLGIKMHGGENLDKFDGGPGVDEVSIGQNISLIHEAIRDGKMQDVVVGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGD6</accession>
    <name>A0A401GGD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0309730</name>
        <name evidence="3" type="ORF">SCP_0309820</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612159.1">
        <property type="nucleotide sequence ID" value="XM_027756358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGD6"/>
    <dbReference type="GeneID" id="38778163"/>
    <dbReference type="InParanoid" id="A0A401GGD6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="416" mass="45594" checksum="AB0BDF49B46E18E3" modified="2019-05-08" version="1">MFKPSGERRPLLNRVNRPPRGRLYDSGTVAVLGAARSDASPSSLAWNIGESTLQSVLDVIRRQCGYVIPWVDFLRFKPSGERHPLFKRKCHSPRGPLYDKETAAVRGAARSAASPHLAAEESASGRMSRGARRDFARRILEAQAQRRASRGAEDIAPTSPPFDAFERSGCIAKAAARSAASLHRALLGLHGLGLTFFDRGPRAASQGLRLSAVQGRTRLHRSPRVSKVEVQRRGARSAPRFPVRVACDIEDDALVVLASSGLNFRASGAGRTSSADRRYFPPKACGRRWSLLLREWMLASPRRLVDGTQRSTAPPLRCASLHQVRRSAVCRGLRDTGVDRRRDPRGESVQRRRARLKSVRRAPRGARHASVCLSHEHSRGRRQSARAVSLDGDAAVSSPGSVLQRTKRGACVAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHC2</accession>
    <name>A0A401GHC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0312500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612434.1">
        <property type="nucleotide sequence ID" value="XM_027756633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHC2"/>
    <dbReference type="GeneID" id="38778438"/>
    <dbReference type="InParanoid" id="A0A401GHC2"/>
    <dbReference type="OrthoDB" id="3269001at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="517" mass="59198" checksum="DFAE4D3A80145087" modified="2019-05-08" version="1">MLEWLTSNISDVQEWIEKVKDPAALPDAITTSHYFDHPLQRGDPLLLLAVFIVLILKLLGQVPRTTCNFALQMLKVLLDTALRQGTRSLSYREEQILDHFPRDIRGVQKAFDLEAVVIVYATCPSCCCTYVPSYQDDIPVYPSRCQHRSGPRSKPCNSQLMTTRVLDGESVRSPIRPFIVQDFHAFVGGLISRPGMEEILRQGKAIRDRYNLRDITNGSAVANMQGPDRKPFADAAEGELRLLWALSVDWFNPYLNKIAGLSISTGSMAMLCLYLPPSMRYKTDNLYLAGIIPGPKEPKLECTNHFLCPLVDQLLVSWERGIWYNRTYDYPRGRRVRSVLALIITDLPGSRKKQSINNIDMTTWKMKTAEEILEAAVRWRDADTQEERKHIFKEFGVRWSELNRLPYWDPVQRIVIDGMHNIFLGVTQFHSRKVIGMDVPIGDREDAGNSRKIKENNLISLRCLLLKDPEPRLLLHFRCYITITHKYRSFVKVSTSPLSTIPGAYSWNGWKLRGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHN5</accession>
    <name>A0A401GHN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0400040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612546.1">
        <property type="nucleotide sequence ID" value="XM_027756745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHN5"/>
    <dbReference type="GeneID" id="38778550"/>
    <dbReference type="InParanoid" id="A0A401GHN5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12620" checksum="51E5759E56DA1813" modified="2019-05-08" version="1">MAALYDHGPGHQLGQGPAPFGPQQLGDDKVWSQAQMFAMQQGIPLFTPPATSHGQAQVHPQQQAAFLMSLQRQQALLQQQQQQQQQQHERRLLLPDLRRVPASAADKQWEHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHR7</accession>
    <name>A0A401GHR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612657.1">
        <property type="nucleotide sequence ID" value="XM_027756856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHR7"/>
    <dbReference type="STRING" id="139825.A0A401GHR7"/>
    <dbReference type="GeneID" id="38778661"/>
    <dbReference type="InParanoid" id="A0A401GHR7"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10890" checksum="E144684BA1C50EFC" modified="2019-05-08" version="1">MKVSYSEPSEIKGWSDLKEAKQEKVHCAWKEDTISDENESIKEAVDTSKKVPAERKNKKDRNNVKKTDKLKQSHAKKAKADKEDEEEAKEEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIG5</accession>
    <name>A0A401GIG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0403520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612889.1">
        <property type="nucleotide sequence ID" value="XM_027757088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIG5"/>
    <dbReference type="STRING" id="139825.A0A401GIG5"/>
    <dbReference type="GeneID" id="38778893"/>
    <dbReference type="InParanoid" id="A0A401GIG5"/>
    <dbReference type="OrthoDB" id="444848at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="144" mass="16998" checksum="A8E7BB577A67A6F0" modified="2019-05-08" version="1">MKTCLGDEWKWLTVMPAVFWAERITIQRSTGYSPYYMAHGTEPLFPFDIAEAMYLVPYEGVQMTRIELLAHRACQLQKREEDLEEVHERVIRARYKSMEQFAQEFHATIKSYDFKPGDIVLVRNSRINMELNRKTKPPVQVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIX4</accession>
    <name>A0A401GIX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0405020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613035.1">
        <property type="nucleotide sequence ID" value="XM_027757234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIX4"/>
    <dbReference type="STRING" id="139825.A0A401GIX4"/>
    <dbReference type="GeneID" id="38779039"/>
    <dbReference type="InParanoid" id="A0A401GIX4"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="1">
        <location>
            <begin position="185"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="346" mass="38473" checksum="455F43D239FFFD58" modified="2019-05-08" version="1">MDHIDPTSLEPVASSVLFAYIQDLYQPPNFLASSVLHAAKTTTKRLRIYLISPFFDVPRRNAGADAASEAAGISHTKHWYGVQRLLTFVYVQATKVAQDSDRVLMDIDVLLKGSKDVLSEKVIQDAQRIFCVLLQSGGTPDLPLFLRQRTDIISLPPDDHPLHSLHPIPPAPDPSVPPMLHVVALGGTFDHLHAGHKILLSMGAWIASEKLIVGITDDALLKKKIYKEVLESLSVRTERTRTFLELFKPGLVYDIVPISDVYGPTGWDPNIQGLVVSKETLPGASSIHKWREEKRLPPLHTFVIDVISSTEASVDDDDAEVLKKTKMSSTYIREWIVNNEARTVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJS9</accession>
    <name>A0A401GJS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0408120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613341.1">
        <property type="nucleotide sequence ID" value="XM_027757540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJS9"/>
    <dbReference type="STRING" id="139825.A0A401GJS9"/>
    <dbReference type="GeneID" id="38779345"/>
    <dbReference type="InParanoid" id="A0A401GJS9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="207" mass="23171" checksum="91384E5ECE34C705" modified="2019-05-08" version="1">MEVQFQERMADLNTIKAEITAALQRINPPSAFQENARSIREEVKLAMEEFRRPVTIELQKSMKLAVADLIAQRHCLPELKEKVNRLEQGTNQMVSRADVDKLQGELADLRHSMELQAAQSDSMEKELRSLAAEVIAQASKLEMELALAKEDSMAVVTSALDEAKKVGKEVTTAREETSLVAKSLDAFREKVDSAMVFTAFRPDSHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKA3</accession>
    <name>A0A401GKA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0409740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613503.1">
        <property type="nucleotide sequence ID" value="XM_027757702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKA3"/>
    <dbReference type="GeneID" id="38779507"/>
    <dbReference type="InParanoid" id="A0A401GKA3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="194" mass="21039" checksum="AAF16BC4941A5544" modified="2019-05-08" version="1">MSSPNARPAGEAPASICSFAVRSSHIPQVFMVQAQSKAASVGIILPLPHDIPVLAQVEIATARTMKAGHRMVPQIADHLPAVIPRGLTACVLYDDPAVHEDFGLGHPPDGLPDIGAQSSYPHFPGIVFLSSALLSSGTLRLRVETLRNAARELYDVMRRITGRRELADGTLRQLRITVEELEIAFGLIFVSYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKB0</accession>
    <name>A0A401GKB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0409920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613520.1">
        <property type="nucleotide sequence ID" value="XM_027757719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKB0"/>
    <dbReference type="STRING" id="139825.A0A401GKB0"/>
    <dbReference type="GeneID" id="38779524"/>
    <dbReference type="InParanoid" id="A0A401GKB0"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="13">
        <location>
            <begin position="395"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="202"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE82607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="680" mass="73949" checksum="13166A85AEE8C02B" modified="2019-05-08" version="1">MPMHTFDPVRDAVMNSPTVSNVHLDIPKRVNNIPFPPSPPSEATPPASSPITRRATDLCVLLNADEPPYETPLFTPTTPRSHPTLSHLLNDPDPPDQLSQMAPLRRRASADLSRDAMHDVPREGSYFAWPAHSSSSPQASALALPGSLPTPSHAATTPHRHTRSPAVSASSSAASSRPSTASRPSASLSSISASMPLQLSHFPRRSSSANISPSPDMPPPPLPSSQTTAPGPSPSPSTSSSANSSPVASTRGLASPAPSFMSKLKPSPKPSSPSKPPEVLPTSPAPSKLPYAPTRRRTPAGSVLIPLSPAELARYRNYSGGVGTLILRKRKRDDDDRDGTGNGERARKRPNDGDAGEDRPDGDSVPKRRRTGDVGLVVEHYNSRPDVGVTQRKDSPIIGLKSFNNWVKSVLITRFAHPVLAASPVASGGPGRGRVLDIGCGKGGDLTKWAKAKVREYVGVDIAAISVEQAAARHAGLRAPRFTASFFPLDCYTHALSAALPPAVLRPFDVVSLQFCMHYAFESERKVRQMLENVAGALRPGGVFIGTIPDSEQLLAQLDALPPNVEELTWGNSVYKIRFEDRAQHPLFGHRYWFFLRDAVDDVPEYVVHWDNFVQLAEEYGLQQMYRKEFHDVFEEHHEHAEFGPLLERMHVVDANGESQMDEDQWEAANIYVAFAFTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKE3</accession>
    <name>A0A401GKE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0410200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613548.1">
        <property type="nucleotide sequence ID" value="XM_027757747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKE3"/>
    <dbReference type="FunCoup" id="A0A401GKE3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="GeneID" id="38779552"/>
    <dbReference type="InParanoid" id="A0A401GKE3"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="212" mass="23257" checksum="8902F827654567F1" modified="2019-05-08" version="1">MAGLRMSIVVSTTAFLLGLLFTHWIADSLSLWKTPETQTDASLWTAATYYSILSRMPPTLAYVYAAITVLGGATLLWSLRDGSAGNLMFDGGSIFLYATTVYVYISSVLPNFFANFTSLSLPPLATSSSILPFPSALRTPTLELASSHLVCSVTLTGVIILQAGRWWAEQSDDDAQEDLMGEGDEEAEEKRLRSRSRSRRREKGKAESKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKE9</accession>
    <name>A0A401GKE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0410320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613560.1">
        <property type="nucleotide sequence ID" value="XM_027757759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKE9"/>
    <dbReference type="STRING" id="139825.A0A401GKE9"/>
    <dbReference type="GeneID" id="38779564"/>
    <dbReference type="InParanoid" id="A0A401GKE9"/>
    <dbReference type="OrthoDB" id="3043484at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="11826" checksum="6026D697AD4131BD" modified="2019-05-08" version="1">MWATNDDPGAWFVVLGGKNPGVKDAEPFMVGSKYTFPLPISVKCDTCNQADDVNRFNELLKPLKKLNPDSCTMLNLMANSPLMAEILPDIDEYYCVVHGSSSGIYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKF7</accession>
    <name>A0A401GKF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0410330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613561.1">
        <property type="nucleotide sequence ID" value="XM_027757760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKF7"/>
    <dbReference type="GeneID" id="38779565"/>
    <dbReference type="InParanoid" id="A0A401GKF7"/>
    <dbReference type="OrthoDB" id="2689725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17136" checksum="372A119330B2A688" modified="2019-05-08" version="1">MKQARRIARAREELDCLNIEVCRFHTAIHDENCAFEVVLLQLEYTGNPLYGAVDNFCLRHHHINVHLLARIRQIYSLEGFTGEAAIGVRTGTTPSTATEASNKPSLEDVSLAHELEEVTLDDREGLDDLGEDDELAGDIGGIVDYVANLPLHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKG7</accession>
    <name>A0A401GKG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0410410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613569.1">
        <property type="nucleotide sequence ID" value="XM_027757768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKG7"/>
    <dbReference type="STRING" id="139825.A0A401GKG7"/>
    <dbReference type="GeneID" id="38779573"/>
    <dbReference type="InParanoid" id="A0A401GKG7"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019444038" description="Cupredoxin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="38721" checksum="5A9052A0A569D799" modified="2019-05-08" version="1">MFFKRLTLSTLLSLASIRVARGNNFSVTVGGPGVLKFDPEFVTANPGDQVFFSFRQENHTVSESSFDSPCSLAEGGFDSGFVPVADNNTAGPFPEAEYTVQDTNPVWIFCRQANHCQQGMVFAINPGNQSQFDAFQAGANGSAVNASVSSSASPSASSSASASGVSSAQGSSSSVASSGSASPSVVTVTATVTVPPSATSSSASSSASPASATSADHTVVVGGTNRLFFNPSNITADAGDTVTFRFMQTNHSVTQSSLASPCVSLTESSTNGEVGFDSGFMPVSDNTTAYPTFTIQINNTAPIWAFCKQTNPMSHCGAGMVFSVNADASGSDDFDAFQTKAIQLNGTQAAAKNSAEGVLTVGRGAGAVAVLLGILAGIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKK6</accession>
    <name>A0A401GKK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0410750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613603.1">
        <property type="nucleotide sequence ID" value="XM_027757802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKK6"/>
    <dbReference type="STRING" id="139825.A0A401GKK6"/>
    <dbReference type="GeneID" id="38779607"/>
    <dbReference type="InParanoid" id="A0A401GKK6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000226">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018821990" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="492" mass="54475" checksum="AE08C65CE61E2894" modified="2019-05-08" version="1">MFMFSLSLLCLSVVATSAAQHPFVLKNRLPLASERYDAGLFSPVGDLGVLSTSRWTTLNHPAFPNYDVRIKKSDFCDGSVGAYTGYIDIEARHLFFYFFESRNDPTNDDVIFWTNGGPGCSSSLGLFMELGPCRVTNPNATSYNPYSWNEKANVFFIDQPIGVGFSYADYGEAVSTTEEAAKDIAAFVAIFFEHFSKFKGNAFHMAGESYGGRYIPVFASEVYDQNAKLIEAGINPINLKSVMIGNGCTDFVTMSPSYYDMQCRPMSAEPIVEISSCVRQKQALPRCEKWLKEGCRDSYDAINCQAAYSFCASEIEMPFFQTGYNPYDISKPCDGELADTLCYPVTKAIGSYLDRPDVRALLGVDPSIVGNFSSCSEVVGHAFNDALDAMFPTQLYIAALLERGIRTLIYVGANDWICNWVGNERMTLALEWTGQKDFTSKPLTEWSVNGKVAGLTRSSGPLTFVTIYGAGHMVPYDKPVESLAMVNRWLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKV7</accession>
    <name>A0A401GKV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SCP_0411670</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613695.1">
        <property type="nucleotide sequence ID" value="XM_027757894.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKV7"/>
    <dbReference type="GeneID" id="38779699"/>
    <dbReference type="InParanoid" id="A0A401GKV7"/>
    <dbReference type="OrthoDB" id="3227225at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="501"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="744"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="790"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GBE82782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1398" mass="156401" checksum="634ECFF4BA5704CB" modified="2019-05-08" version="1">MSSTSTHTPNFAKLNDSNYPTWSGEMAAWLRSANLWRLVNGKLPQPKLSGSPTAAEQTKLDTWEANAEKAAGQIYLMVEPDQRTHFAGVVDDPIKMWEQLAAVHLQKKPGARFNAYDDVFSIRKQPEESLQGLVNKVNAAMQRVKDLHPNDFNLTKLDEELTSMAMIRALPVEEYGAFTSALLQRDILSKDVVTQAFVTEEINRRHRTTSPPKADQALTTASSSQLTCDFCEGKGHTQSNCYAFQNASKKAKENRKERRSKRGNKANATAAAAATQNTTQVDPTTVTESAGKASLSDPLQLDADFDWNADTGATSHMTPHHHWLRNYKPLVIPIKLADNTIVMSAGVGTVVFNSVIAGKAVRPVEFTRVLHVPRLRNNLLSCLYLVRQKGFRIHIESKFMTFLHSRQTLFVASITENYTAFLDGTVQPAPESAQAITTVPLDLNLWHRRFAHHNYADVQKMIREELVTGLMLNSKQQPDPICEPCLAGKMHANPFPTSDSHASKPLELIHTDVHGPLPVCTHSGYRYWITFIDDYSRFRVVLLLKAKSEAFDAFKQYKAYAENLLEAKIKAVQDDKGGEYMSNAFIQFTQEAGIERRHTTHNRPQQNGVAERANRTMDNDITAMLAESKLPPSFWGECIGSMVHVWNRLPTAVVKGATPYELWYKRKPDVSHLCVWGCTAYVHVQKDQRTGLGPHMQKCVFIGYPAGYKGWKFYNPDTKKTIISERADFDERYFPGLKCTSDIPPPPPMSFPPADIIPLPVAPVPGQDLGGDGAHVPNPIPGPVASEADPPAPPAPEHPVTPPPPDPSEHHRVPTPPPFEPIDHRPIAQRRVPRNIRPTWKMRTSPPPMQDAESEDELDVINADADFVEVQFAGLSAGADPRTYKQAMGSPDADKWQQAANEEIVSLMANNTWDIVPLPPGKRAIGSGWVFKVKHNADGSVERYKGRLVAKGYSQRPGFDYTEVFAPTFRQPALRLILALAAAEDLELHSVDISSAFLNGDLEEEIYMQQPEGFHQGGPEMVCRLNKSLYGLKQGARQWNKKLHEVLTKMGFTRLQSDRSIYVYIREDVRIIVPVFIDDMTLASKSKKALDDTVKELKSYFKLRDLGSTQFLLGIDIKRDRAKHTISLSQRQYIVDMLERYGLSDCKSVSTPMDPGAELSKALAPQTQEEAEYMHKVPYLSAVGTLMYLAITTRPDIMFAIGCLARFNANPGPAHWIAVKHVFRYLKGTMDLRLHYGPSDVKEFFLTYTDSDFGGERNNCRSTGGYLVKVGTGAISWSSKLQSLIAQSTTEAEYIAAVEAGKEILWMRNLLTELGYTVSKASTLYMDNQSAISVSKNPEHHGRMKHLDLRFFWLRDTVEAGRIAPVYIPTAEMIADILTKPLPATKIIYCREMMGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL92</accession>
    <name>A0A401GL92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0413250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613851.1">
        <property type="nucleotide sequence ID" value="XM_027758050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL92"/>
    <dbReference type="STRING" id="139825.A0A401GL92"/>
    <dbReference type="GeneID" id="38779855"/>
    <dbReference type="InParanoid" id="A0A401GL92"/>
    <dbReference type="OrthoDB" id="3260945at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="34"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="324" mass="36396" checksum="9E838A1D5C37B2C2" modified="2019-05-08" version="1">MSIIPAEGSSEWLELLIVQKCGVPSVRDFQLRHGMDLIRGKDLFLVIAPGQGKTTVMHAPLLAAQAQMKIGIALMIVPTKLLALQQETVANSHGIRALAINEDTMREAYHNNRDLLAELVGGEDIRLAIMSPQMLRSKRVRSLLSQQAVKSLVCWFFVDEAHLVDKQSGEWIEIFKSIKTMRAILSARTVWAAFTGTATPSRTLVLAENLGFQPGHYVNTRYSVDCSNIKYIPRFFEHAVSGTDFLDISFLIPLEMASPTDITTTLIFCQTIELGYKIMSFLDRLIPEAVPHRNKIIKLYNSLMPATYRQHFVQDRLSGAELHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM84</accession>
    <name>A0A401GM84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0503810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614246.1">
        <property type="nucleotide sequence ID" value="XM_027758445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM84"/>
    <dbReference type="FunCoup" id="A0A401GM84">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GM84"/>
    <dbReference type="GeneID" id="38780250"/>
    <dbReference type="InParanoid" id="A0A401GM84"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE83333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="297" mass="32277" checksum="30AF07D3468691BE" modified="2019-05-08" version="1">MLARRTLGRIASQPAVLGAAPSNARNMATLREIELRLKSVKNIEKITKSMKMIASTKMARAQRAMVAGKEYGIANSEVFQNAPAETSGKRKLFLVISSDKGLCGGIHSSVTKFTRKTFADKEVPMDPESPVMVIGDKSKAQLSRAMPKSLVMTFNQIGRDIPTFADAAGVADLISKADVKYDSIAIVYNKFVSAISYEPAVVEIETENVLKESPGFRAYEMEDDVTKDLAEFALANAIYAALVEGHACEQSARRNAMDNASKNASDMISRLQMQYNRGRQAAITNELVDIITGASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMK1</accession>
    <name>A0A401GMK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0505200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614384.1">
        <property type="nucleotide sequence ID" value="XM_027758583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMK1"/>
    <dbReference type="STRING" id="139825.A0A401GMK1"/>
    <dbReference type="GeneID" id="38780388"/>
    <dbReference type="InParanoid" id="A0A401GMK1"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="394"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="699" mass="75405" checksum="D3F4C89F8B3D65E4" modified="2019-05-08" version="1">MSAAGVQTNVVQIHRRKSSKEDDENILVFPSSQPAESPAVPPLSEAIGQRGLLPSEAQPRPVSYPAMSPSQSYPGQPGQYRPRPPSLNGAPRGRVAPAMRQSLSLPSGSHSRTRSVSGPFYPASPSPLSTSFPIHQPPTPGALKFPTSSTAPELYARTQENGTPPMHTRRHSRLHSRNLSVFFPRPGSLPHDVITEDGAQDMAYSDSAQAIEGVLMPSASPGPGQRTFRENFTFGARPPTTSSPHPMPAMSPSVSAGASRRGHHHKHSLSHNFFSFLEPGGGLPTSPDELHTLATPMPVSPWAPISPLQTPADEKVGSLHTAVKSPIGRVRASPDIPASAVGAAVAQFLLGVWLWISGQQVGSLSCTGLGYWVIFDALGVVLSSVLPGYLAGPSMRADIRRPFGNTRVETVVAFAQSVYLLFASVYVCKETVEHILLSSGEGHHHHHGDEVTEIFGIDFPLFLLCTTFVSLLLTSFTFNNHSKLVSTAGNHIPPLTALLPSRYRYGSLSPLSFPPRLANLLANPYTLAPLVFCTSILCTSLFSPPYQQRPYDLILAGFETVVTFSLAYSATVALGAVLLQTSPSRGLPGGRMEAFLRAMREIERHPQVLHLPAPHFWQLTPNLTRPQPYSAAPNTKILGPTQSLVVTVELHVRKELEDDEVLRLTRWAWERCSAALHFGTRTGEGGDAEAEVTVGIVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMV3</accession>
    <name>A0A401GMV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized GTP-binding protein, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0505990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614458.1">
        <property type="nucleotide sequence ID" value="XM_027758657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMV3"/>
    <dbReference type="FunCoup" id="A0A401GMV3">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMV3"/>
    <dbReference type="GeneID" id="38780462"/>
    <dbReference type="InParanoid" id="A0A401GMV3"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="4">
        <location>
            <begin position="66"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="315"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="596" mass="66471" checksum="23EFC979A73334D7" modified="2019-05-08" version="1">MRLVDLLRPHVKPWHAPLTLRASTWQISRVHSASLERKEDEPTKEQLEEALKRKRRTEWKRRQGGQSFLDHTIIHVRGGKGGDGCVAFHREKFVPYGPPSGGNGGRGADVYIVPTPHLTTLSSVPTRIYGQNGGTGQGTWQSGRNSPPLIIKVPLGTVVKELPGDDPRRSKDEYEAEAEALEGLEFEERKKKLRERRWVHYPDYEEVNVERDSFKDAERVLYKEERERRFMRRRRALQPIHLDLDKPEETVEAADPNAPLGTRRHEPMGHLIASGGSGGLGNPHFLTAVNRSPKFATRGYEGERVSLFLELKLLADVGLVGMPNAGKSTLLRALSGGRARPEIAGYAFTTLNPFVAVVRVLDDGSFEGSVEGAVYDETFIEEQREKEMMENGALADAPTRNQRPPVSDSVWDDPEDLLEAFRFTVADNPGLIAEASANVGLGHSFLRSIERSHALVYVVDLSSPAPWDDLRVLRDEIEKYKPGMSPKARMVLANKADLLGGSKGPEDTEAVHEARAKLKRLEDFVALEMAIQNQDASGNIYGERTLDVVPISAKYNQNLQKVVNLMRGYVEEARRGAESPVPSQIDRDVQAIRASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNI7</accession>
    <name>A0A401GNI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0507960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614653.1">
        <property type="nucleotide sequence ID" value="XM_027758852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNI7"/>
    <dbReference type="FunCoup" id="A0A401GNI7">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNI7"/>
    <dbReference type="GeneID" id="38780657"/>
    <dbReference type="InParanoid" id="A0A401GNI7"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="396"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="598" mass="68050" checksum="1C0845DEAE9E4D1D" modified="2019-05-08" version="1">MSSTHTSLPAAKKRKVSGSDDVTSPIRQLETQLTSALSTNSSLNQLADLLDIVWSTQDAALLGKAIYAMYRVFVTIITNGLLFGREDVGQDTKLVRSWLSEKLHAYVDFVAALMSDEDLTLRTSALEILLSLQKHLSTSLTRQSIARNPQPQFHVLHFRKIVHSLLLCPPSPRTPALSKNQGVEAQSPVTMLDPDVKKLYADKWMSVYDDIRWFFLREATTLLGNVSREQQTTAASNMLSMLETINTFPTTSFELNTWWVDELGVNPPTGNRSKLEFNQIVEESEKGADEEDDWRKYFDDPPADTDEIKCRSRTARLHTLTLHQSLHSLASHRAVFTRAWLTLLPLLSLNASEPSRTLVLRVLNMLHRRVLPHLTKAILVMDWVGSCVDYGGAVGLLALNALFVLMKEYNLDYPLFYNRLYGFLDRDVLHLKHRARFFRLTELFLSSTHLPAVLVASFVKRLARLSLDASPSAIVMIIPFIYNLLRKHPALMCMIHRVEDDMNADSFDARESNPTLTNALNSSLWELHAQKDHYHAVVSTLACIFEEAFTRPTYAMEDFLDHTYNTLYDAEAKRRIRKDPVVEDEIGRFTGQIEDLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNY0</accession>
    <name>A0A401GNY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614825.1">
        <property type="nucleotide sequence ID" value="XM_027759024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNY0"/>
    <dbReference type="GeneID" id="38780829"/>
    <dbReference type="InParanoid" id="A0A401GNY0"/>
    <dbReference type="OrthoDB" id="3264915at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11069" checksum="0EAD934576F662EC" modified="2019-05-08" version="1">MSLRAHGSEADYHIQQLIDLFREIDAARDPTPSSKYIPRIKAVETIDEPPKVSKLLKNKARWWMIVLGYCTSSCVPFVAFLFSSGKVIEILNKMDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPB0</accession>
    <name>A0A401GPB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0600430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614978.1">
        <property type="nucleotide sequence ID" value="XM_027759177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPB0"/>
    <dbReference type="STRING" id="139825.A0A401GPB0"/>
    <dbReference type="GeneID" id="38780982"/>
    <dbReference type="InParanoid" id="A0A401GPB0"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018993867" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="240" mass="26539" checksum="79A6F2EC70DE8AF3" modified="2019-05-08" version="1">MTSLQLLKLPLLCTAATCSQIAFTAPNPPAKAEEVKKFGRKDPGSYIGRLLLSTMKLLVWFATLCEIAVVIASHFPHPLSVQVLSVLVSAPPSFISNVRVTASSLLGWTLVCAGALLRVQCFRTLGRFFTFELSVKAEHKLVMNGPYAVVRHPSYAGTLMVASGNLLYFFGAGSWFAECGVWSTMMGKILALILIIGFGFPFVSVPLRIKKEDAVFRKEFGVQWEEWAKRTPYRVLPFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPQ7</accession>
    <name>A0A401GPQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0601990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615134.1">
        <property type="nucleotide sequence ID" value="XM_027759333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPQ7"/>
    <dbReference type="GeneID" id="38781138"/>
    <dbReference type="InParanoid" id="A0A401GPQ7"/>
    <dbReference type="OrthoDB" id="3263183at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="334" mass="38202" checksum="5438924A230563C1" modified="2019-05-08" version="1">MSSVLLNPDFREGISLPLSTFYEEIRLHQAQYSKHRLVKATHYKEQTAVAHEFLILDVFDGKHLLSLRVERRPTTKKPEGPSTTTFPHPYVRITDDRISRAPPDFKPSSFYKIVVMRCPTKPLFSLPDVCTIFHMIYESSPNYSLLSNQCYWFCAVFLWGLEKKVKVAKTKGKDYDLRGTFAKAIRVLGDEQVEKDIDEYNERLQRDREESALLERLTAKQIYFVALEQKRRSSADSTKKTLVVVNPLLETSENKRRREELAVKSMFAKVVQTAGDNRDDEKGDAVLQGLMSPLPSPKGEREIHFVASPPPSPPSSPGSLRPTLLCRWFQPGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR07</accession>
    <name>A0A401GR07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615580.1">
        <property type="nucleotide sequence ID" value="XM_027759779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR07"/>
    <dbReference type="STRING" id="139825.A0A401GR07"/>
    <dbReference type="GeneID" id="38781584"/>
    <dbReference type="InParanoid" id="A0A401GR07"/>
    <dbReference type="OrthoDB" id="2804729at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="437" mass="48848" checksum="228941A36E368A69" modified="2019-05-08" version="1">MSLLSLNDDVLAAIILFMPPSEVLPFSRTCRYAYSAAIPQYLSEVTIKSTLQLAGFCAFVLAEPFHRPICIHGLDLALQIFHEQDICASVCALTDILRRAICLDSLSVRNLENLLLFGPSLRNVLAALPALRQISFRGIGEISLAVLSQMASRPRHVILDTFWNEAGYTCEGALDKFAQCLETLEIRRASGFVKLNAEVVWPHVRTLHVAYIDHSTSLSRLAYAFPNVRHFKSMASRPFLPDHGPHWAFLDYVEADIPVELFSSIRRLVLRCPYSRESSEINRLTLDMLRRASPVVLACQVHRDIVPHIADVLPALKYLKILVREDLAKSSIESRSLSIAHAVQKLPLVALSLCHGDRWPTALHCDISRLQCIAREVAAVLPTLKDVGFDGPLLLPRHDVCRWFRVTDRNGDTPQLRLLSRQEGDGLEAQLATMGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR70</accession>
    <name>A0A401GR70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615618.1">
        <property type="nucleotide sequence ID" value="XM_027759817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR70"/>
    <dbReference type="STRING" id="139825.A0A401GR70"/>
    <dbReference type="GeneID" id="38781622"/>
    <dbReference type="InParanoid" id="A0A401GR70"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="1">
        <location>
            <begin position="15"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="696" mass="78391" checksum="858815281FC640FF" modified="2019-05-08" version="1">MALPLVWLGNYTFFPIGTTSAVCLTRDLSPEERADVLLLGCGDLRSVLYTIFCEAEKRRRLDFTCCDLDPGVLARNVLLLTMIADNTYPVTTIVWNMFYHISLDEESHTALITQCKKLINFSDNLQCWNSSPYGAFTRMCTEYTLAQLRRYWVLYVGMQNMPTERKQSLRETLLKEYQVAPAALFWMASRSAGPFRLSAFESNVKFGQYWDAGVTFSDPAQIAAATYLNPTFVYSFGGEGCIVYPFTHPTVDFHLASVVGNSYGSADVFDLVKAAQMQFYDWCSAFRASICSTRHPTPVIRILLAEATAACYAFQSFRTAKTASASVLVGPWTTQTIQLSKEDYPSRSAPIRFNVIDASDLEDNVGLLNILTAVVPLLSHPSRCSVLYTESQHYQTTGDQSLVYEDGTGKPLPHDDGARDFTQRVYADMTTIALVVGVCPVDYLSCFSSHCNTDELIVRTLFRQTGDSALFHQNLTWRVPASGDTTARPDKCSYRAIPGALVFTPRQLGTLLFNMYCRMFNHEEERLFFGQDGPLSTVEAVSLQCNIVHNTSESFILFLKFVKQTHQLTDDGWAEVMDQLIGLRETRDQAFTQQRSDYQELLAQLYRHGLYMHAPMLAAAPKCSLLSTWESVPLLLRIVFTVPRQSLTVLDRAEVEYVARRSSVMLQGEVSAAMDTCRFMLLLGMQSKRVRMLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR72</accession>
    <name>A0A401GR72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0607070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615640.1">
        <property type="nucleotide sequence ID" value="XM_027759839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR72"/>
    <dbReference type="STRING" id="139825.A0A401GR72"/>
    <dbReference type="GeneID" id="38781644"/>
    <dbReference type="InParanoid" id="A0A401GR72"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="70093" checksum="41446F159D640197" modified="2019-05-08" version="1">MSAQSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVHWEEGLRREMFAVRGICGDLALAGHADHIDHGGVIASVLTICTFNREVLRPISIDVKAIPRPTTLVPHPKNLLEDSPDYWWKWDRQVGLAGSPMEAWWYKLGDPWEKVYTVSESTLVQLEQLHVHVANLTSWLHERTDQNLDVVLEELQEATRQLPCGKECRNSSGLTQHYNSAHALPQQHVVLNSVLQQDEYEYEEPQNSGPQFLDHEDFPMDGPDEDDGDGQVMEPQIFEHELLNGRPCDAYMDDWTPYSSRVEFEMAEFLFKRDQMSQSKINTLMALWAASLLPYGADPPFADHTDMYCTIDVTPEGGIPWQSFTAAYTGTLPKGKVPSWMTANYDVWFHDPHAVIKSMLANPDFNDEFNAAPYREFTGPAEHLKLELRHAQKSTAEHVERADKLKKQNDALELRVHELKKAGTSDQADLRELRMKLRVTEHERAQLAVKQGEAWQALQVAESRTKQEVHERGRKLAEVEKGLNLKRKKRELSACMRRSSLKMGYGVRALQALNSFYSGEYFNLDEVSNLEHAYLDPAAIDKSTSLLTDQPMIRTATAMPPLLEMLNHLGVLSSGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSN1</accession>
    <name>A0A401GSN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616151.1">
        <property type="nucleotide sequence ID" value="XM_027760350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSN1"/>
    <dbReference type="GeneID" id="38782155"/>
    <dbReference type="InParanoid" id="A0A401GSN1"/>
    <dbReference type="OrthoDB" id="2754671at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="435" mass="47728" checksum="FCD24878B472D1FA" modified="2019-05-08" version="1">MSAASAPFFERTNTCRTDTLRPNIQTSPTFKPSLPITIPRRKSVRPPPRSPIRHQASPDFVFNFDFSVSPCSLHGRQQMVMNYATQPLLQQRGHASVLIPHGRQNYARCSVDIDADLGLEKRPYSNEPFLYSVPKIFLCHHGAHMRTQSPPQPCSTSTARQSDDRQKVGGRQVAHPVGETHVPANPLVSPISSSLSSSMKQSLSLSRGQDNLVACGFADGKSYGEVSDDGRLISAFQRRVASDSTSASDAPSVSTPFASPASSPPSPVSPAVLAPPSPVSPPPRHSRWRPTVPTTFRRSQMRAPIARTAAAPVVSFKVAQAERCLRLKSAFSPPYGEAERRSRSPFPGLGLRSRRGSSVASERGIRTVVGIGRNLNVTDDERERRVSVVLSNEDLERSLEKILEQEVSADEKDWEIERGRTRGRTLTRGKVALRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT01</accession>
    <name>A0A401GT01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616250.1">
        <property type="nucleotide sequence ID" value="XM_027760449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT01"/>
    <dbReference type="STRING" id="139825.A0A401GT01"/>
    <dbReference type="GeneID" id="38782254"/>
    <dbReference type="InParanoid" id="A0A401GT01"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="15797" checksum="C10BA82FC68EAD6D" modified="2019-05-08" version="1">MHTLKDLLGYLKGSDAVLLRICRELHLNASVQLLFRDADDGERGVEVLCDRVVDMSDDCLDTQLWCHLQENYGGKLLRAVDWPEQQRDIEVHWVTETPKVNSIESPYIAYSNDASAAHTYMYLCLIIEVGKAGNRETAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTH9</accession>
    <name>A0A401GTH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fatty acid synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0706700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616396.1">
        <property type="nucleotide sequence ID" value="XM_027760595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTH9"/>
    <dbReference type="FunCoup" id="A0A401GTH9">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTH9"/>
    <dbReference type="GeneID" id="38782400"/>
    <dbReference type="InParanoid" id="A0A401GTH9"/>
    <dbReference type="OrthoDB" id="2789709at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3330:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="4">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase subunit alpha acyl carrier" evidence="6">
        <location>
            <begin position="333"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase type I helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE85483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1091" mass="121060" checksum="F971C4AB7131E441" modified="2019-05-08" version="1">MCAVNPSRISKTFTDAALQEVIDDIAHRTRCFLEIVNYNVEGQQYVCAGELVALQTMTNVLNYLKMEKVDIAKLTGKFTVERVKEMLGEIINSCFTRAKDQQKAEGYIKLERGFATIPLPGIDVPFHSCYLWAGVMPFRAYLSKKINAAHLNPDTLVCKYVPNLIAKPFQVTKDYVQLIYDQTLSPRLDKVLRKWDTENWGSAEQRQKLAYITLVELLAYQFASPVRWIETQDILFKHYNFERFIEIGPSPTLTGMATRTLKTKYEVQDDSVSRIRAILCHAKNTKEVYYQFEDEAEAAADESVPEVAATPAPVAAPVVVAAAPVSAAATDPQKLKKKVEEIPLSKSIKDLVGGKSTLQNEILGDLQLEFTSAPEKGEELPLEELGSALGIGFSGSLGKYSSGLVSRVVGSKMPGGFNISAIKAYLSKTWGLGPTRADGVLLLSTTMEPPKRLGSDAEAKAWLDTFVTLYAQRSGISLTTGAANSGGGGGAGGPTINSEEFLQFQADQEQFAAQQIELYMRYLKRDSRAGEIKYDAEKANVVSLQSKLDAISREHGDTYIDGIQPVFDALKARHFDSSWNWVRQDALLMFYDIIFGRLTTCDPNRGDTCKLAKQFGQQLIDNCREVLALPPLYKDVTFPTAPHTEVTAKGDIVYSEVVRENVRKLEAYIEEVASGDTISALMNIQKIQDDVLKLWNVVKSQPEISEEQKNRIKALYEGVIRSLRKRPESRPRPGAPRPPDKVPLLHLKCKVGTNWEYSSNLTGVYLDILHEIATSGTTFKDKNALLTGVGKASVCVEVIDGLDNKSELAHRIMLINLLRLLGAVKIEKASRQILTRPTQVILPLSPNHGLFGNDSLYSESKVSLETLFNRWNSESWGEYLCLAGAVIGWTRGTGLMDATNVVAHDVESHGVCTFSAKEMTFNIMGLMHPLLFSITQVEPIWADLNGGMDRLPDLADITTRIRTDLNKKSELRRTIARDNAADFKMINGVEAECVLQTVNVVLRTNFKVEYPALESHESLADVSKLRGMLDLEKVFVVTGFAEVGPWGSSRTRWEMEVRGEFTMGTRADGVLQLSTTMEPSKRLGSDIEANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTL3</accession>
    <name>A0A401GTL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0800790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616475.1">
        <property type="nucleotide sequence ID" value="XM_027760674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTL3"/>
    <dbReference type="STRING" id="139825.A0A401GTL3"/>
    <dbReference type="GeneID" id="38782479"/>
    <dbReference type="InParanoid" id="A0A401GTL3"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="117190" checksum="6826BE2B3A5D74E4" modified="2019-05-08" version="1">MKFKAKNGHSKHARTYHPKDPLARIPISLPLQQYTSRDHQGEGSNERSGADLEDRRDGSVGPDAQAPHVQERAGSGADADAIGDAPDHYDFEHADNFGFRDVHMDFEGVDELGRDLYEDYEGSPNPHHAHGGDSDGDHSMGDKRDTPSRTSMSPDAEDPTRPIIQNHPHIYGRPCDEFGNYLPRDVPPPPPQAPAHDDWYPYRNRTEFETAELLFARDEMSAGNIDALCRLWASSLVKDGDEAPFADAKDLYQRIDNTLLGEVKWQSFNMTHNGLKLDNNAPAWMNADYDVWYRDPRLVAQNMLSNPDFDGEIDYSVMCQFEREAPHQHHLQDFMSGDWVWKQADLITQDPDTHGSMFVPIILGSNKTTVSVATGQNEYYPLYMSIGNVRNNVRQAHRNAVALIGFLAIPKTDRKYADDIQFRKFRRQMFHSSLSKILQPLKPGMTTPEVTHCADGHFRHVIYGLGPYIADYPEQALLACIVQGWCPKCTAHSSNLDGSEGGRCSRAHTEVLVEELGLDVLWRDYGLVGDIVPFTNDFPRADIHELLSPDLLHQLIKGTFKDHLVDWVEQYINSKYSPATAKSILADIDRCISVVPPFSHLRRFPEGRGFKQWTGDDSKALMKVYLPAISHYVPRKMVHALRLFLDFCYLARRDVHTEKTLADLDHALKRFHRDREIFATCGVRISGFSLPRQHSLVHYRAHIWAFGAPNGLCSSITESRHITAVKKPWRRSSHYKALGQMLLMNQRLDKLAAARVDFTSRGMLAESALVAAMNIHIRGLENDMPNPDADAGPTAQREDDIVPGPRSKEYVKLAVTLQRQHSRSIYALADEIDQPHLPTALRHFLYGQLHPNRDISGTIPIDACPEVLHQDKVYVVYSAAATYYAPSDPSGIGGMRREYIRATPSWRGVGPCFDCVFIKSPSADPGVNSFDIAHVQLFFNFRFRYIQYPCALIRRYELVDEQPDRDTGMWIVRPRTDDGSISVIHTDSILRAAHLIPVFNGPIPEGLTEYHSLDVFEQFYMNKYVDHHAFHTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTW4</accession>
    <name>A0A401GTW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0703600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616087.1">
        <property type="nucleotide sequence ID" value="XM_027760286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTW4"/>
    <dbReference type="STRING" id="139825.A0A401GTW4"/>
    <dbReference type="GeneID" id="38782091"/>
    <dbReference type="InParanoid" id="A0A401GTW4"/>
    <dbReference type="OrthoDB" id="2751668at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="737" mass="83979" checksum="4088569587E75908" modified="2019-05-08" version="1">MPVTRRQSGRLPPPIRRTLQVVSVIDADTTDGTESSVTDLEHEDEDESASDWDGGRVQRKQPEKKRAKVTSPNLKKSPKQKYVAALTILPTMSLDILFEIFCLLNPATLLNLARTSKAFRDTLMTRKAITVWKHAWVYNSDGAPACPPDMSEPRWANLLFGGTKCQECGASSIQKIDFALRRRVCSSCLKKNLVYSVSFPKRFPDFDTAILELIPHTNVGGWSHGHASASKFYWEADIYPMAQEFGQYQRNVHIHKPGAKDALKKFRESRMKFVEDVLEHAEVCNEWINNIYESCRQDAEARKCVRYDAIVRRFKDLGYEATDISDIKYLPQVNVDRELTSRTWARIQPQLEPHVQRTKQRRVARERAALLHERRKMVKQVYGSYKKTLVPMQWIYLPTLEEIYLMPDFADLINSATAEPLRVETCTGALRALPGYLTTRADRLRQEMLAMLPAENGKEEGEVLEFSSSETDPVFLAKSVFICTSASCKSNRVLISWSGVMSHDCLIASRTSYSYMSTYHVDPAFKGLEFGFSERGAAAVSALVSLLEPKRQLDEISSKDLDDLDPRFVCMNCPIAKARGVHGRLAMSWRQCVLHHVERKDETHVLSQWMILPKDDEQRLKRQEGGDPSYNSLHWSCNHCPTHLDNLQRRNAAIEHVKKMHAEAQPRENKDFFHVKPSQRTGPLPQGLAMGPGASKDFRCLICSKNSRTFIESGVKAHLKDKHQIITPVQNEHYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU78</accession>
    <name>A0A401GU78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0802990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616690.1">
        <property type="nucleotide sequence ID" value="XM_027760889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU78"/>
    <dbReference type="STRING" id="139825.A0A401GU78"/>
    <dbReference type="GeneID" id="38782694"/>
    <dbReference type="InParanoid" id="A0A401GU78"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF24">
        <property type="entry name" value="SLR1182 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="251" mass="28350" checksum="1F7ABFCDC3F50EF8" modified="2019-05-08" version="1">MSPSFQTKKLEKACVYKPTPLLKIPLLASNAVFMFIGLTSPNPPPKPSELSKYDRPDSISRGNFNALIHIIKSVAVITAAAEIAVILAQEYPSLSEHISLLLPSPSSGLRVTKTFVASWALIGMGGLVRWWCYRTLGRFFTYELSVKEEHRLVTVGPYSIVRHPSYTGMIMQIIGAVLWSLDPGSWWSNLDRFSATARNSCVVLWLSYWIIIPGLAVSRLSKEDRILKKEFGDQWEKWSRVTPYKLIPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUW6</accession>
    <name>A0A401GUW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616896.1">
        <property type="nucleotide sequence ID" value="XM_027761095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUW6"/>
    <dbReference type="GeneID" id="38782900"/>
    <dbReference type="InParanoid" id="A0A401GUW6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="11170" checksum="95EEBB6EF5ED9C4B" modified="2019-05-08" version="1">MKRGDERELYIPLDSLSISFVLLAIRYRVHQLYPRDPELLEHMWKFNAGEGDQTKCRNISEPRKWKQSLEDAALGMTLFPPQMKLRVGKCERHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV48</accession>
    <name>A0A401GV48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0805830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616972.1">
        <property type="nucleotide sequence ID" value="XM_027761171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV48"/>
    <dbReference type="STRING" id="139825.A0A401GV48"/>
    <dbReference type="GeneID" id="38782976"/>
    <dbReference type="InParanoid" id="A0A401GV48"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="159" mass="17564" checksum="85B482C23EE2CAED" modified="2019-05-08" version="1">MSSTRPIVFMDRHRPKNRRELQTTLHRRVQSEFAAAGVQKCDVPSLLNRVVPNFMCQGGDFIKGDGTGSFSIYGDKFPDENFQEKHTGPGLLSMANSGANTNGCQFFVTTAKCDFLDGKHVVFGKVIDGMLTLRKIENVPTGPNNRPKLAVKIVECGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV66</accession>
    <name>A0A401GV66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0806390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617028.1">
        <property type="nucleotide sequence ID" value="XM_027761227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV66"/>
    <dbReference type="STRING" id="139825.A0A401GV66"/>
    <dbReference type="GeneID" id="38783032"/>
    <dbReference type="InParanoid" id="A0A401GV66"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="215"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="495" mass="56009" checksum="448D347A00F4C071" modified="2019-05-08" version="1">MGRNLRQVTNAPMHHHRVHNFSVSIHGLRARLLRWDMSVLIAQASFGLREKHKVLCGFLWRFAHGSTVGRASSGEERLSASSGAEVKDEVRAEYEAQCALLEKTVALHYEAGRICAEDGRLERCLVSRPVATNFSMRQGAMRGYWAVVGGRVVFLQDTWRQYVLEPEGRILRELEAHRAVLGHGELRADDSEQGGPTTTVLPVHRVALIPRGRLIGFPLQTLQGTKELLNAAHDAFQALIAAHDKARRIHRDISAGNIMLYRKPSQDHRTGYLIDWELSSKVQEDGQATDKYIVRLEARSQRRHMLQDDMEALLYVVAYCGLHWLQHPAHSRDTRLVVQALFHNGREVRAGDVPGVTHMTFQMMEPGKGKLAIKENQTYVDGANFNADLKDWLSRSMDLNHPRDVNAATQWDMPEPWNDYWTEFLGRQLPEDDRIRKQDSSSMRPKSAVKAISHRAGIHPNKRKGPQCRGRTEDGRTNGVLGNGRPVKRLKRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVG2</accession>
    <name>A0A401GVG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0900580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617093.1">
        <property type="nucleotide sequence ID" value="XM_027761292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVG2"/>
    <dbReference type="STRING" id="139825.A0A401GVG2"/>
    <dbReference type="GeneID" id="38783097"/>
    <dbReference type="InParanoid" id="A0A401GVG2"/>
    <dbReference type="OrthoDB" id="2800708at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="611" mass="67957" checksum="F58584898DEC4FD2" modified="2019-05-08" version="1">MGNKQHRDAAEKDEHIAMLEAQIEVHAAHTSQMHARLLSTLDAMDALRTAHSRELKAERRAIERLSTKLDHYLEDLKRAEAKRDEMEEITSVLLEKVELSKDYALWPRSQIHLTSPLEPLHEQQGPFPSGDAKVLQMYASAVVASLQLELDAERRAHVQTRDQAESDLISLNAQLARREAELETCIVHPCHDQPTAGPSSLRLTTQMSTEDKLPPAVAMFTREEAIKVLEITAAKNHALEIEVKELVETLEKARQAQNTPEPQPVPVDRFHTFAGPRDHVGMFPSQAHDSPRLNSPSTPALPPSSPGLPPFVQSTQASPSPYSLAQNIANPSPHASPGQTLVLVRLEEQIKAFATEIDRFKTERDTLGAVLVEGRKKDHDSGTGGNPQIHLRQPSHTEEEYTRLVRSEDALRHELDAVRDSWKKREDELQREIETLQQALSTVTLEHSVTISAAPYANRQSVPEKTNTALTDILDDDKAEVSMELATPLQPTIISLQVDDNHRTDECRSSLYIPLPPSPSLASSTPPSLPNPQIVFPTAASPRPPRQAEGDAAGRLDEIERELALARMELEERDEALRELREFVGQLREMVEASEEPEPDGEQQRGDGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW05</accession>
    <name>A0A401GW05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0902410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617275.1">
        <property type="nucleotide sequence ID" value="XM_027761474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW05"/>
    <dbReference type="GeneID" id="38783279"/>
    <dbReference type="InParanoid" id="A0A401GW05"/>
    <dbReference type="OrthoDB" id="2799665at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="905"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112886" checksum="95853D3FA658DE94" modified="2019-05-08" version="1">MSGSSHPGANDGRSYNLRTALFTGFPPYPVTNPQAPACSSAPASHAADALLTLSGGQPYAPDHGSWTTIPRHARSPLNRATATGGASSSVAHSVPSADSNRYSELLRHHDTDSDLEGSEFTGSDEEESDDEDVSGIISNDEVAFNLPRMTTSKKHERRAAQQAQDVINQHLPARKRKRKMKDSTSRKSSSKSKRARTDTAPVVDGPLASVSHTLAQTSSSIHVSSAHDNPNVASSSTVNEDQVRNCNGKQRKTKKPPSPIYMFYREIKENHKLHFPNWKPADKLYMCLHGHNKVLRISEGMNGSTTGLKNHLKAADESMYKLYQILEKKRALGQKPTAQEILVARAEMPLQSLGYNVDQPDEVSQAATATGDSNRLAEPFDQATWERLVSEWVAACDQPFDAVEAPEYVRMVQYASRVGDHLKVPCGDTIKKRIMEMGDNVISDIKAMLSAVEGKFTLALDCWTSSNQWAFMCIILTFVTESWDIEEVMIDFREIIGEHSGENLAEAVWQTIELYGLKGRIQAVVADNASNNDTMVEALERCFKAENIPFHASHAQMRCVPHTIHLAALELLQAIGGFSSTNNHEQSRGKYQATPDNYQEALQEPLTTEADNLLSQANDSVNCNNAHADDDVPGRILSALDKLRKVVRVVRSSPQRKRQWLDEVNLSLRRLEDAFDKAEEALMLILDVRTRWSSTHQMLRRALEYKEEIWLFIAKRVDLRHLELDELEWGAIKLVCQWLLMFRQATEQMSSSKEVTLSSVHTIFHGLQEHLKNALRKLPPDSPPQLRDGLLRAYKKLSDYHSHFDESPYYIWACPVLDPRINYEGLKAEAAMDANPQSRDEYLKHIKDAKAELKTYYLNHYHSSSCENGAAATLSSSIGGKDQTPANFNFFAPYAPPVDRAPSEELDEYLKLKNLGFGNRVSHPLRWWKEHQDLYPSLSRLARDILTIPGSAVAVERAFSSGRDTVSLRRASLKPVTIRKLMLVKHKLMLARRQLKRALEEQLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW42</accession>
    <name>A0A401GW42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0903270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617361.1">
        <property type="nucleotide sequence ID" value="XM_027761560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW42"/>
    <dbReference type="STRING" id="139825.A0A401GW42"/>
    <dbReference type="GeneID" id="38783365"/>
    <dbReference type="InParanoid" id="A0A401GW42"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001211">
        <property type="entry name" value="CBN-PRP-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="4">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="211"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="505" mass="56280" checksum="774FB592E5BB5371" modified="2019-05-08" version="1">MSELTLDTLIDDGNYLGSERVRQENKMLLDELERKKKARSLAVPTDDNRVKARLREIGEPITLFGERAADRRDRLIYVLSQINAARGEEAMQVEEESSEESEEEMEEFYSPGPLELLEARRRLAEYSLPRAQKRVAQQRIDSKISLGRIIDIRKKIFAEVKQFANLGSQIGDDRPISQVRFSPNSKILATGSWSGNVKLWNVPSCTPIRTLRGHSDRVGGVAWHPQATLSQSESSVNLVSGAGDTNLHLWSLNSETPLSVLKGHADRVCRVAFHPSGDYVASASFDTTWRLWDVNTSKELLLQEGHSKEVYSVEFQNDGALAASGGLDAIGRVWDLRTGRTAMVLDGHVQAIFAIAFSPNGYQIATGSGDDTIRIWDMRSLKALYTIPAHLSNVSDVRFFRGDELPDTLASASPDVLMNGIDEQPHQAEEHAAEEWRYRSGLYLASAGYDGFVKLWSADDWQLLRTLPTDGGKVMSVDLSSDAKFLASGTYNRNFQMFAPDESII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX43</accession>
    <name>A0A401GX43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0906340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617666.1">
        <property type="nucleotide sequence ID" value="XM_027761865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX43"/>
    <dbReference type="STRING" id="139825.A0A401GX43"/>
    <dbReference type="GeneID" id="38783670"/>
    <dbReference type="InParanoid" id="A0A401GX43"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="1">
        <location>
            <begin position="298"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="2">
        <location>
            <begin position="592"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="836" mass="93988" checksum="14B93147C78F50B6" modified="2019-05-08" version="1">MGEPREGILVVERERIAALVDEDFPLRSRRLLAASSPLDPQFTLLEILWTLRAKIGTRPMLVFEDRLVDLVHQEIAFPYADIIQDQAERINIREELDKGMENWIAGRLQSIDNMSDAIQSVLNVIGGLEKNVKKEDEDEDGALRLPSAYPEWWRALVSSYVAVSVQARYGLCLSLVTLLFFVSEDLPQWDPALLAEIFVVFRGIAMFRYATRQPAAGSVSTPAAEPLTDEEVVAKMRDMHVSSTASGFTPSYSLIHRLLTQYGSDAAIVPASAHLFLASSGLLESLSPANATKLEVLFCERLRLLGYRKVSRESLAWLPRTAGVTYVLGRLWLDEGRYDDAASVMEGVAVSFGRDSALTTEDHEALAGVLPGAAFFQSVFDFYLHVAGLFKAVSVTSSEVVFSQLALSVAPPGVDSASLWHAVIRGLTDLELYEDAIWECVSQLMYRMCEEHAVDRLMALSFVGFVDEVEESLSFKARNADPRVRPFYSRILYMWYISRGDYRNAALTMYQRARKLASLFGDPANFIEIAELRLEAYVVGMNALVLTDQKNAWIVLPVTAESEHEPRKRRKLSRYIPEDKYGPGKRDMEVVELADMQYECTLLAIRLELIHRDPTLLSVGEALLSPPSVVLRLTQANRFNMAMATGAHAQLNVDMTDLFGHLTGLSSVDSGEDTSDWLLTDKVTSWPGTAADRGWRYLRESLERHDGPDTDYRYTKVTLETILELDRTSPPPQWLTQSLEVHHPEYLIRTCLRYEMFEGALEHTLSLMRRSDAHLAQERPKAASVTWLPYTLIDQVLAAVDTQQGLPIGAQSLRKELRTEISNRIKRVQKCGQSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX52</accession>
    <name>A0A401GX52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-induced GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1000050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617676.1">
        <property type="nucleotide sequence ID" value="XM_027761875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX52"/>
    <dbReference type="STRING" id="139825.A0A401GX52"/>
    <dbReference type="GeneID" id="38783680"/>
    <dbReference type="InParanoid" id="A0A401GX52"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="41"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="824"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="692"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="917" mass="100812" checksum="B6EDBA0DE147A84E" modified="2019-05-08" version="1">MLPHGTAQEDLLLSSDSSYAQRCKQVLNLVKNLRAIGAQADLDLPRIAVIGNQSAGKSSLVEAISGITVPRDAGTCTRCPMECRLSSSSGSWFCQISIRWEFNDDGRRKDEVHEVPFGQLITDKNKVELMLRRAQAAVLNPTIPCSRFLTMSADELKEDFAANGLKASLPFSKNVVCIDLTGPELTDLSFVDLPGIISNAEPDIVKFVEGLVRSHIKGNCLILVCLPMSDDIDNQRAARLASEEDPSGSRTIGVLTKPDTLPQGATKSRELWLDVIEGRHHALTHGYYCTRQPDDEERNAGITTAKARAAEADFFAKTSPWCISTHQHRFGTPSLIKNLSKLLTQVIDDVLPKLQGEVSAQLSKCTTQLDRLPQQVNTEPSAFVLNLVTAFCTDVHAHVQGGPSTASLVQKNRAVYAQFKRSIRLTAPPFIPYPRAEEAEADSMKFLELDEEESSNEMAVDDSMAVQPKYMYLNDVRQFIRQSITRELPNNVPYPAKVALIQAFQNQWDRHSQNCFDAVDTEFQRTLFHIIQTKFERYEHLKTRIQLVMRELVKHRRDATLTYIQSLLKLETTPFTQNDHYLAEKTTKTLARYKDARAGKVAPEKATPASNFFSNGPFAESSNRFAAFVPTPTSNLPHPLVPSREPSATPTPTPTVSTENSTFSFGVPSAFARPAAQTQSPAIPIIFNGQTVQQSAAPTNDGISQPQPSPSTPAFATGKANGKAKENGSTNPLLPPSYKTQLASEAPLNGVRTLGTSPENSSSSVTTRKPTPASAAGHIMRALEQPGNNPEDVKAALAALAKIGYNVLEVDLGKLNPPDEYEEELQVMAEVRAYFQVAYKRVIDYVPLSIDHLFLYAFAEDLQAFLLNKLGLGGPNATARCEAYLVEDAGVVAAREELTSKKKRLESVQVELFNFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXG9</accession>
    <name>A0A401GXG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1001690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617838.1">
        <property type="nucleotide sequence ID" value="XM_027762037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXG9"/>
    <dbReference type="STRING" id="139825.A0A401GXG9"/>
    <dbReference type="GeneID" id="38783842"/>
    <dbReference type="InParanoid" id="A0A401GXG9"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="6">
        <location>
            <begin position="144"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="496" mass="54489" checksum="E9088A78793B4D15" modified="2019-05-08" version="1">MDGAPAQSCVTPPRRKRTWTPGSITNAYSTKRRRISMTTVELAKEISSQVESRTPGHTTVADRFITARPKFAMPFNITPRSQRIGRQFGMAEDRMLKFTEAKSSGTEDIGLRANFSQLLTTPPKISPTSAAMHLGSRKQFILALDGPGIPSDPFAFPLSWSARNAIAVACGRDVYYQNLDTRSISHLCTLTQRRRGRLASIEWANTKPHLLGLGTTTGCVQLWDVDSKTVLREWEDEGWGQVGGMGWNGDVLAVGTHHGDIVLYDVREEHEVSRVSTHRGGVLGVRWSHDGNYMASGDDRGVVHFWDARAGKALTNENKLGSKMKHQGPVKALAWCPWKPDLLATGSTYSDGRIRIYSVHSTAPAAEPLHTLSLNTSVTSLIWSPHCKELLSTHGTSWQPRASSMSTLSSISAHFRPVPVKGPLTNSLTVHSYPSMRRVVSVPAHSGAVGHSCLGPDGTLVFTICPAEEAMKMWKVWGVSENVQPRESVFDKCSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXK9</accession>
    <name>A0A401GXK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized amino-acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1002110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617879.1">
        <property type="nucleotide sequence ID" value="XM_027762078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXK9"/>
    <dbReference type="FunCoup" id="A0A401GXK9">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXK9"/>
    <dbReference type="GeneID" id="38783883"/>
    <dbReference type="InParanoid" id="A0A401GXK9"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF9">
        <property type="entry name" value="AMINO-ACID PERMEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="552" mass="59381" checksum="2030B56C5252D822" modified="2019-05-08" version="1">MSLPALLQADMKTGHAPLPADVDTRSVTSTGATDDDERLLEIGYVPSFRREFSNLATISFAFSIMGLCSSVATTFNTPMLLGGPASATWCWILGASMCFALGSSIAEIVSAFPTCGGLYTASAQLCPPRQRAVVGWIVGWLNLLGQIAGLASTEFGLAGMIWAAVVIGKDSNYVVTQGMTVGLFTGLLVLNGILNCLATRALARFTTGFVFVNLGATILIIIVLLAKTPRSEMHAASYVFGSAGLINQTGGWDTAISFFLGLLSVQWTMTDYDATAHISEEVKRAAYAAPAAIFIAVIGTGILGWLLNIVLVLCSGPIENLPGPSGSAMLAIMAMRIGKPGALLLWTFVCLTAFFVCQTALQACSRMVYAFSRDHGFPDRGYFGQVTSWTKTPLRAVWFTTFWSILPGLLDLASPIAANAIFALTAMALDLSYIIPIFLRRLYRNHPEVIFKPGPFYMGDGLLGWMANILCISWTLFVCVIFSLPTVFPVTPQNMNYASVITVGVIVLSGVWFLCGGRRHYKGPSSNVPSYDHDAVDRRNSRDGDEKAEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY49</accession>
    <name>A0A401GY49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1003260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617992.1">
        <property type="nucleotide sequence ID" value="XM_027762191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY49"/>
    <dbReference type="STRING" id="139825.A0A401GY49"/>
    <dbReference type="GeneID" id="38783996"/>
    <dbReference type="InParanoid" id="A0A401GY49"/>
    <dbReference type="OrthoDB" id="2799068at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="39867" checksum="7925D4AB48FEE906" modified="2019-05-08" version="1">MAFSEQSYPSSSSVISWPLLSEESDASLLSDDDPSLPVKRRKMARRSVSHSYHITNTKPFWYSDGDIVLEIEQQCFKIHQSRLKCSVIFSDMLEVPQPADAESVDGCPLVQLADAVDDWIMTMKWLYDRRIFQSLPHPIPFQLLQGALRISTKYDIADLRKTTIKQLRARWPSELERMDTNSLPHAAEAISLARECDVLEILPAAFYALSIQRWGCNADGGQSHQVLTPGDLRRLVIGRERLSSICAGILFDPLLTEDLPIDAPSPFDACAKCRDVLQRYWREKVCSSPSSPFECWLLRELHKLMVEGDARFERTLCARCLAWHKSAVIMRLFHLKTSIPRIFHLSFDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY81</accession>
    <name>A0A401GY81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tigger transposable element-derived protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1003980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618064.1">
        <property type="nucleotide sequence ID" value="XM_027762263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY81"/>
    <dbReference type="GeneID" id="38784068"/>
    <dbReference type="InParanoid" id="A0A401GY81"/>
    <dbReference type="OrthoDB" id="3064354at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="464" mass="50740" checksum="A4E037D50A3AFB44" modified="2019-05-08" version="1">MRAKDVVGLYLAARQEAFKVEMVKQAWRKSGIDSNPEGSKVQCNPSIFTATDFAPSVSTSTQVHLLDGFPIASTSLSTPGASSSTASASLSTTCDSPYDVSDAPKSCFGSDEEEDDPDLPAGMPSATTTSSAIARLPSPSLIADASAAPSTQLPDLGPPPQYNDDSSDSDFSDTGYDSEIREKLAKLRRQRNKAREQRDTAVSHAILAGNHIKLLQARLNTKTSKKRNGRIVHIGGRVTMSDEAREEALQQKLARDEKAKKTQETRQKQEDARVERARHQQNSRTGMKFAGALSSQKLPVLRDIAWSLELPEDGKKDQLIARIKAYFDRDENSVLCNNNQFAEIFATHGSKWCAAVLTQENTRNDNNNAEPGPSQRQFAEPLTNALSTPAPWQYNPLPYAGSAQWPAPYGTPYGMPYIPQSSFTVCEQPVSTTAHEESHTPVPALTYPQYSFSHVPYGPPYTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY86</accession>
    <name>A0A401GY86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="3">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_1004090</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618075.1">
        <property type="nucleotide sequence ID" value="XM_027762274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY86"/>
    <dbReference type="FunCoup" id="A0A401GY86">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GY86"/>
    <dbReference type="GeneID" id="38784079"/>
    <dbReference type="InParanoid" id="A0A401GY86"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 19" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="18">
        <location>
            <begin position="127"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="184"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="598"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="714"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="762"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="723"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE87162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="837" mass="92923" checksum="50A7341978CFEC96" modified="2019-05-08" version="1">MSRSPSSAGRGTSPSPKWDQDGESEVDDTDTPLARADSVKADAMDDDDDMDALKQGEPVQDASFAKSDARPSRTPPLSSRGKTKPEPAGPQLIGHLPHAEREALQTFVELPGNHYQYGTLGRSREALESMTCDCQYDHGVDRPSDACGYGSDCINRLTQVECLPDDCRCRSYCQNQRLQRQEYAPIDIVLTEKKGFGLRAGEDLIKDTFIYEYIGDVVSQPSFLKRMRQYAEEGIRHFYFMMLQKDEFIDATKRGGIGRFANHSCSPNCYVAKWTVGAHVRMGIFASRNIKKDEELTFNYNVDRYGHDAQPCYCGEPNCVGFIGGKTQTDIAAMDDLYLDALGISEEVAVLGLKGSKKRKSKKLDEDFIPTLKPLQEKDVPKVVQAMRQTQSRKVLFKLLTRVKLTEDQSPLRQLMRLRGFSVMTNILEDYSTDLEMLTLAVECMMTWPLIQRNKVEDSKVNVPVQACAQSENAVLAELAKKLLAQWDTLEYAYRIPKRLKGEDDEASPPPVIVLAADDGEDTRAAKRFKAEPFDALLEDASLHIRPLGRTAVYTKPVHHIEEVFDGNAGAVARPTGPSRADIAAIIAAASAAAAAASASASQTPAETSDAGARKRHRHAHRKESSEEKEANKEKRLLKLVGAVVVKCMSKYQKQMDHDVFKKHAKELTHLIAEKEKKSSSYKEGRLDALSEEKTTKIKKFAKEYIAKILRKLEKAGQRRKPPSTSDGTNGASVSTSTPDTHDDLEDGDEGVHMTVEEAMDLDEDDGDGDGDGESHETPPSSTSPEEQMRGRKGEDRPAAIGVSDPRLRHRNEECGWDPHQEKVEVLQGFGTVLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYT6</accession>
    <name>A0A401GYT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transposon Tf2-12 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1100030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618241.1">
        <property type="nucleotide sequence ID" value="XM_027762440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYT6"/>
    <dbReference type="STRING" id="139825.A0A401GYT6"/>
    <dbReference type="GeneID" id="38784245"/>
    <dbReference type="InParanoid" id="A0A401GYT6"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="515" mass="58487" checksum="AABB695549074721" modified="2019-05-08" version="1">MCPSSSPYSSPCFLIPKADPTALSHWVNDYRILNANTIPDVHPLPSIQEILSDCGRGKIWGKLDMTNSFFQTRVHPDDVLYTAVVTPFGLYKWTVMPQGCRNAPATHQCRMFTALRPYIGLICHVYLDDIIIWSNSLDEHHCNVKTILSVLCSHHLYFSRKKTDLFCLELCFLGHHISHAGVEADDSKVDKILSWPVPSSASDVRSFLGLIKYISNFLPALSQFTCILNTLTTKEAEHNFHWSSTHQDAFTAIKSLVVSRERLMVIDHQNMGDNKIFVCSDASDWCTGAIPSFGPTLESACPVAFDSMQLKGPELNYPVHEKELLTIVHALKKWHVNLIGVPFSVYTDHHTLKNFTFQKNLSWHQARWQEFLTQYNFNIVYLHSEDNTVADSHSRLPPPLAPLAPELTPIHPATIASLPLFWCAARGLSSIQVPPLIPPCDIFTHVATTHLCVATDPDWLTRIRTGYREDKWCSHLLRDLAHTVTKLLSEERADDFHLYLYRSYDNDITVPRLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZP1</accession>
    <name>A0A401GZP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1102990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618535.1">
        <property type="nucleotide sequence ID" value="XM_027762734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZP1"/>
    <dbReference type="GeneID" id="38784539"/>
    <dbReference type="InParanoid" id="A0A401GZP1"/>
    <dbReference type="OrthoDB" id="2673594at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="137" mass="15723" checksum="4727022489AAA825" modified="2019-05-08" version="1">MTADVQREGELGTSTPQSPAKNPRKRRQDDDPDQREESGTDAPSQPRRTRRKTVRHDYRLMHDPEADKDLDNDPDKSNAELVYIAMSAHGNADADEPKTLSDAKRSLEWPKWEQAVQMELNQLQGMETWELVEPPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H003</accession>
    <name>A0A401H003_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1104320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618668.1">
        <property type="nucleotide sequence ID" value="XM_027762867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H003"/>
    <dbReference type="GeneID" id="38784672"/>
    <dbReference type="InParanoid" id="A0A401H003"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019146540" evidence="2">
        <location>
            <begin position="27"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="183" mass="20261" checksum="3E739D7373CC91AB" modified="2019-05-08" version="1">MTSSPRSSHMMSQLPLNLLLWKITDGTHLTAHDNDFHALFSTKILEIQILDINSTLIDKTRPHGQGERRSDVSMVQGMVVRDPETWHQVSSFFVTVYRDYVLPFHGRNEYDDGVEGSKKPTVVILGTIKLTSKSAARGGIDLMDDITMKESRNMPTPADHAVAVGNQAKGDRNKVGKASSNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H008</accession>
    <name>A0A401H008_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1104430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618679.1">
        <property type="nucleotide sequence ID" value="XM_027762878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H008"/>
    <dbReference type="GeneID" id="38784683"/>
    <dbReference type="InParanoid" id="A0A401H008"/>
    <dbReference type="OrthoDB" id="2803662at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="86" mass="9668" checksum="D196CD0B1D3662CF" modified="2019-05-08" version="1">MALLDGENIEHLEISSNEVADEEGWTMEDVKENPEDIEEEVLPENITLLLPSSLGIEQCKMVGWESIAQQELQLRVGQANDCLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0S8</accession>
    <name>A0A401H0S8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618902.1">
        <property type="nucleotide sequence ID" value="XM_027763101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0S8"/>
    <dbReference type="STRING" id="139825.A0A401H0S8"/>
    <dbReference type="GeneID" id="38784906"/>
    <dbReference type="InParanoid" id="A0A401H0S8"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="160"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="378" mass="42867" checksum="D1C273CB1323F3F6" modified="2019-05-08" version="1">MADLAEDPFVEANDDVLRRITEALRVDSRADLGITLHKLSQNYSRVRKVAESRAERRKLEGQVVVHSRALASPTERPSSARLAFARASDPTTVLWPFSAQICSLLGVSSYSTTSPPSFPSFPQILNCGRTIWENTARAVIQLCDGILVKVGQLERDEPVLLDFISSHAPGIPIPKPLGFMKIGKISYMFMTVIPGAPLEERWSFLSQDQKISISNQLNEMLVELRRIEFPPGTPLGSVSPRHLCVDTRISMRPSPHTLFTESEFSDFLVSRPLPNVSAMVLKWFRSLLRDDHRIVLTHGDFHPRNIMIVEEGDEVRVSGIIDWEMGGWYPEHWETIKTFNTRGCDEDCDFWDYLPDAIAGYTHELTVDFIMDHFISIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H144</accession>
    <name>A0A401H144_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619022.1">
        <property type="nucleotide sequence ID" value="XM_027763221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H144"/>
    <dbReference type="GeneID" id="38785026"/>
    <dbReference type="InParanoid" id="A0A401H144"/>
    <dbReference type="OrthoDB" id="3001771at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="235" mass="26357" checksum="1AC56EA8D4841C2D" modified="2019-05-08" version="1">MGSDTNVAVHVNSTGKRAIDFPLDVLINIFELVYPESREPFVSVKTKHRPLFSWEEETRTCWKDEDPLSPTFFPEALAAVCPSWRAALSQISVFWTRIVIVVDDEPTPLSTVRTSLALSEPHFIDIIICRRHDHDLNSTAAERAYIDAVMALLDPHKQRWGSLHIDLRTSLESPSPITLNGDAHSLVALNIDSTEDANIQNSPGFCFHGPQLLKLHMGGLAVSRHYLVMPKRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H175</accession>
    <name>A0A401H175_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">SCP_1203980</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619081.1">
        <property type="nucleotide sequence ID" value="XM_027763280.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H175"/>
    <dbReference type="GeneID" id="38785085"/>
    <dbReference type="InParanoid" id="A0A401H175"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="527"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="768"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="799"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GBE88168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1435" mass="160492" checksum="715DE354ED4B3FA8" modified="2019-05-08" version="1">MSLYPPISQASSKAESKRLYDVPFLESNGGNFQTWKYRTTTILRLLGLYSLIDGTEADPGTVDTMKKAEWDVRNNEALAQITLTLKDEPLNGVMYSMTAQDAWEKLNRRYEGRGKQTLAYLISDLFRSTLSDESPLEPQLNTMQQKAHILETLGLTLDDTLIAIAMAISLPPSYSTLRTILMASDSKLTVEKVVNEVLSEEKRRGETTAASALIAKHADTKSKSKGKDKDKKKKGKCAFCGYTGHTKDECRKFKASQVEGTTAKGDKKAEKAADAKESAKIVSVSEADSEMLRLFVAEELARGDDLHRWIVDSGASSHMTSHREWFVNYRALATPKRVYLGDERFILAVGIGQVTLHAAVDHGSTNTGIVQEVLHVPDLNGNLLSVSQFDRNSYDVRFADDTCHISNAQGRLSAIGYMRRNLYVLDVTTQLPERTYILQAEDLPPSYDDSMDDPPLHAFVAKETTSSASAQVWHRRLGHISVDSVLKMVRKGMVKGMSIVGEKVSNVTCKPCLHGKQTRQPIPKESDVENPHILHRTYSDVCGPMQTQTRSGHRYFITFIDGHTHHLVANLMKKKDEVLSHFKAFVERAEVETGQRANILRTDGGGEYESKEFEAYLKEKGIHHEKTNAYTPQENGVSERMNRTIEEMARSMLNDAGLPNTYWGDAVLHAVHILNSVPTRTLPDNLTPHEAYTGNKPSVAHLRVFGCKAYVHVPKEKRQKLDSKTFECTHLGFATNRKAYRLVHRATSRIVESRDVYFDEGTKVAPSRITIDVTPTQEAPDARPELPLSPRPPRPTVEDVPDEDEDTPALLDVDDSDDEDDDDNADEDSDDDVPLPEIRRRRHAARAAQPPPPPPPAPELRRSGRTRTAPVAADDDRYFVSSYTRKPKGQDDVGGVGADAAAADSENAEEVGNAENAHKATSWDEPQTYEEAMSRPDAARWKAACAEELHAFVKAELYDEVERPRNRKVIDCKWVFKIKRGPDGEIEKYKARLVAKGFTQVEGLDFNETFAPVAKFASVRTLLALAAKLDLEIHQMDIKSAFLNGDLDEEIYMKVPPGFRRSNSLVWKLNKALYGLKQAGREWYKKIRAEFEALGFTRCHSDHSVFYKNDDGILLIIAIYVDDMLILSDNLTAVTTLKEDLKSRFEMTDLGEARWLLSMEITRDRPRRVLELSQHQYVEKCLAQHGMADCCPVSTPMAQNQKLVKLSEAEIDPKPYQSALGSLMYAMIGTRPDLAFTVGALSQHAATPGKEHWIALMRVYRYLHGTADKKLVYCGTTKEKEPLLGYVDADWAANVNDHRSVTGFVFLISEGAVSWSSKRQHSTAQSSTEAEYMAGAHGTKEAVWLRAFLSEIGQVQKGPTPLLIDNQSAIALSKNAAFHERTKHIAVRYHFIREKYDSGEIEPEYVPTGNQVADVLTKGLPREKHEKFSAGMGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H190</accession>
    <name>A0A401H190_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1300090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619108.1">
        <property type="nucleotide sequence ID" value="XM_027763307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H190"/>
    <dbReference type="GeneID" id="38785112"/>
    <dbReference type="InParanoid" id="A0A401H190"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="132" mass="14702" checksum="B291EE7F8AB380A2" modified="2019-05-08" version="1">MINWETGDFWFGKDAKWRPKPTVEDVPDEEVSIVKEDEPPELITTETFPTSSGPLESIREITADNTERDELPAVRNDTEPDDPPLEPSTDQLDDDDLVISYIAGKPVIGIFEPIGKESPLTNEGTETAVFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H193</accession>
    <name>A0A401H193_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1300200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619119.1">
        <property type="nucleotide sequence ID" value="XM_027763318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H193"/>
    <dbReference type="GeneID" id="38785123"/>
    <dbReference type="InParanoid" id="A0A401H193"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="27377" checksum="DEFCC3F569B3A7F1" modified="2019-05-08" version="1">MSQLTLSVDEIMDMDNWKQFQLRGSRDDRGSIVYRGLYKDANEDGQLKGEFLDDDSDRGETFLVNRDHTGSPPLSNNESKKSDKLDNTKEEHKETIHQPLSYAPVSDVKEDIKEDIKEDVEEEGKAEAKDEDENEASVPALPSHVFRATHLLESYAGQKDVQLLLKWMSLDAKAVDSYVILRCLSLLLFMMRTAYSPPIQLYLLLLMLLSINITRSSRWHRSLWGCQQVNMAHSTMVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1D9</accession>
    <name>A0A401H1D9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1300600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619158.1">
        <property type="nucleotide sequence ID" value="XM_027763357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1D9"/>
    <dbReference type="STRING" id="139825.A0A401H1D9"/>
    <dbReference type="GeneID" id="38785162"/>
    <dbReference type="InParanoid" id="A0A401H1D9"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF75">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="276" mass="30226" checksum="D2D6BE3D78AF0E3A" modified="2019-05-08" version="1">MSYPVRLPATRSVVTVTHPTPAIWIIELHNGADSRLTEEFITTALMPSLDVVEKHWREAFRAVRQTEDKKGAEGALIIVGNRSQHKFFSNGLDFAAVNSNPVSTATFFPHVFNPMVRRVLTFPIPVVAALNGHTFAAGMALALCCDYRVMTDGSSRNAWLCMNEVHFGSGWPLTLAAIMRAKVSDPRVLRKVALEGHRFTPQEALQAGLVDHIVKGDTDAVLAKAQEVAESVRSCPTFGAWGVIKRDLYRDVVEASLRDVAGHSVAVEDALAKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1V9</accession>
    <name>A0A401H1V9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1302420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619340.1">
        <property type="nucleotide sequence ID" value="XM_027763539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1V9"/>
    <dbReference type="STRING" id="139825.A0A401H1V9"/>
    <dbReference type="GeneID" id="38785344"/>
    <dbReference type="InParanoid" id="A0A401H1V9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE88427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="546" mass="62024" checksum="A1F91EE4CF5E7320" modified="2019-05-08" version="1">MAVFTLSRLILSLGLAVVFFTFWKLVKVLIWRYNSSLRYLPGPPSSHWLWGNMKAIFDAEHSVLHEEWVERYGPTIKYHGFFNLDRLFTMDMRALNHVLSHSMNYEKPEHTRFNLSQVLGSGLLVVEGEQHRQQRRIMNPAFGPAQVRELTEIFLEKARELRDVWSDKIAASSGSARINVIEGLSQMTLDSIGLAGFNYEFHALNPHGKPNELYEAFNFVFSNLASNRYPVFQLLRSWVPIFRRIPTEMSKRTDAAQAKMKEIGMQLLAQKKEALLKAAQAGKEDERLGGRDLLTLLLKANMAIDIPESQRLTDADVLAQVPTFLVAGHETTSTATMWCLFALSQVPEVQEKLRDELLSVPTENPSMDELQELPYLEAVVRETMRIHAPVPSTIRIATEEDIIPLNTPFVDTRGEIHDSIRIAKGSNIFIPILAVNRSKALWGDDAHEFRPDRWIEGVPEAVASIPGVWGNLMSFLGGPHACIGYRFSLIEMKCLVFTLVRAFEYELAVPVEEIMRKSGIVTRPLLRNEKEKGSQMPLLVKPYRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Y6</accession>
    <name>A0A401H2Y6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Inositol oxygenase</fullName>
            <ecNumber evidence="4 13">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1401930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12 13">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 13"/>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619701.1">
        <property type="nucleotide sequence ID" value="XM_027763900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Y6"/>
    <dbReference type="STRING" id="139825.A0A401H2Y6"/>
    <dbReference type="GeneID" id="38785705"/>
    <dbReference type="InParanoid" id="A0A401H2Y6"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="10823" checksum="94F920241866C332" modified="2019-05-08" version="1">MKYLYHVLRKQSSLPEEALYMIRYHSFYPWHRKNAYSHLMDSADQRALAAVLAFNPYDLYSKSDEPVNTEKLQPYYEGLIKKFFPAVIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H318</accession>
    <name>A0A401H318_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1402340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619740.1">
        <property type="nucleotide sequence ID" value="XM_027763939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H318"/>
    <dbReference type="GeneID" id="38785744"/>
    <dbReference type="InParanoid" id="A0A401H318"/>
    <dbReference type="OrthoDB" id="2803382at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="124" mass="13444" checksum="396F6147F536043A" modified="2019-05-08" version="1">MDPIPRRLSRLMALERTARWVEMQAAESDHAPRPPSPSSTRQSPSTRTTTTSDRKSLPQHPSPPNPAPSMPRRHSDAPAKSAALLPFPQSPPGSGYPMSLEMGPPRADVDSDKASSADRGCHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3E7</accession>
    <name>A0A401H3E7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1403730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619878.1">
        <property type="nucleotide sequence ID" value="XM_027764077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3E7"/>
    <dbReference type="GeneID" id="38785882"/>
    <dbReference type="InParanoid" id="A0A401H3E7"/>
    <dbReference type="OrthoDB" id="2612908at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="126" mass="14127" checksum="AE1CECBCB94663F6" modified="2019-05-08" version="1">MKSFPQLKYYCIIAGRDTGIYLTWDECEEQISSFKHQKHKSFNKLPDALRYYIRKGDEGPVESFDALQEDSPTQASTHTQPPTQASSHSQPPDADSDDDAVRTLITDLSLGKEIILDIPATPVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3G4</accession>
    <name>A0A401H3G4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1403590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619864.1">
        <property type="nucleotide sequence ID" value="XM_027764063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3G4"/>
    <dbReference type="STRING" id="139825.A0A401H3G4"/>
    <dbReference type="GeneID" id="38785868"/>
    <dbReference type="InParanoid" id="A0A401H3G4"/>
    <dbReference type="OrthoDB" id="2715572at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="567"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="845"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="943"/>
            <end position="956"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE88951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="997" mass="109448" checksum="C3FAC74EED97BF39" modified="2019-05-08" version="1">MSLTSESHLSHLNIVPKLAADGSNWITYKERMFTVMGSRGLLRHLQGTARRPPNPPPFPMPSPAQAAMTASMTPATAVSTTATTGTGTTTTSATTTPAARQAQSSMTPEEYLKTVEAAEQKLDEYVQKEYAARQQIYGTISDQLLLRVKKLGTAVDVWLAVQNEYESKSDMYSGALRTRLQNTKCEEGADVRAHLDTLAKMREELASMGAPISDADFSAHVFASLPETFSPLLQALSTAARVAKTTLSADDLLASILEEHDRRKAHLKPESALSVKADMRSRSRSKSRGRGAKSKDMECYNCGRKGHFSRDCWREGGGKEGQGPKDQSPKKDSSGSKNAKGKPAANAAVGDSATDHAFTATFDSTALAAKPSEVKVEVYDSGATRHMSPYRDAFVTFKAIGLKPITAADGRKFHATGEGTMRIEIPNGDQSTTVMLEDVLYAPEIAFALIPIARADTAGYSTTFENGECRLYSRRHSRTIGRIPSTNGLYKVEHPKSREVASVAEESKDECALVSLSVMDFHRRMGHIAPAIAEHLVCEGRVKGIQLTDKASPDKNCESCIQAKITRQPVPKEREGGRAKELGDRIHSDVWGPARTETLGGKRYFTSFTDDATRWTDLYLLRVKSGTFSAYKLFEARLKTQDGKAIKALQSDRGGEYLSQAFKDHLEVQGTISRLTVHDTPQHNGLAERINRTLPEHARAMLITAELPKSLWGEALMHAMWLKNRTSTRALDGKTPYEARYGKLPDLHDLHEFGAKVWVRIEDADKLESKARAGRFVGYSDESKGYCVYWPEKRSVSVERNVRFINQLIVADEAQPEGAKETVVLTSPATPSAPAQEPEYEPRTSETQAAPPATSPTASLTPSSDAAAKEPASAKSDSESGTGHSQRARKASAYVKRLNDGSGIMDGRKRQLRTARVRKMNPSLQCQPHLQCTKVKSRDPSRKPCKARTGRSGSRRLKKRCKTFMTITRMISLNRLRILTLSVQNSSSGSSTMQMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3T1</accession>
    <name>A0A401H3T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Benzoate 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1500660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619976.1">
        <property type="nucleotide sequence ID" value="XM_027764175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3T1"/>
    <dbReference type="STRING" id="139825.A0A401H3T1"/>
    <dbReference type="GeneID" id="38785980"/>
    <dbReference type="InParanoid" id="A0A401H3T1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE89063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="538" mass="59405" checksum="22ADD3C6C9D53D00" modified="2019-05-08" version="1">MSIIGALSSLSLTSWLALIASLVVLIHVVPWLLDPHGIRSYPGPFVAKFSDVWLGWVAPAGHRSEVVHDLHRKHGTFVRIAPNHLSISDPAAIQEVYAHGNGSLKSNFYDAFVSIQRGLFNTRSRVDHARKRKIVANIFSHKSVLEFEPHVRLHVATLCNQWDRLYDLGAKGLSGTEGEGGWRGRDGRVWLDCLPWYNYLAFDIIGDLAFGAPFDMLHTCADSAPVAVHHKAAIDGYGDMSKCQSVHFPAVQVLNDRGEYSASMGVLPPHWRPIAKRLIPWYSRGNQAVQRLAGIAVAAVARRMTAPSDRTDLLGKLQEGKDDEGNPMGGGELTAEALTQLIAGSDTTSNSSCAITYHLAHNPEVQRKLQRELDEALGTDDDPVATYEQVKRLTYLEDVINEALRVHSTSGIGLPRVVPAGGLTACGRFFPEGTILSVPTYTVHRDVQAWGADSDVFRPERWQEGDKAMMQGAFNPFSFGPRSCVGRNLASMELLVIVASILRRFEFVLEEPEKPLQTREGFLRKPLGCKVGIKRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H409</accession>
    <name>A0A401H409_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1501220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620032.1">
        <property type="nucleotide sequence ID" value="XM_027764231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H409"/>
    <dbReference type="STRING" id="139825.A0A401H409"/>
    <dbReference type="GeneID" id="38786036"/>
    <dbReference type="InParanoid" id="A0A401H409"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019467923" evidence="10">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="65"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE89119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="459" mass="47886" checksum="26F9AA86C0AE5F3B" modified="2019-05-08" version="1">MLSTLPLTLLAVLPLVSVWAAPSCSLRSSSASASGISQSPSGSSGSSPSSSNSSGSGTNGAGGDIVSMAWYTGWHSTYLSPQDVSWSNTTTPDVNTLALTSEDTTLLPEIVQNAHANGVKAMLTVGGWSGSQYFSTAVATAANRTAFVGAVLGLVKQYNLDGIDFDWEYPGRLGVSCNMISDSDSANFLTFLQTLRAEPAAKNLTISAAVGIPVFTGSNGSPMTDVSAFASVLDFVEIMDYDVWGTWSGSAGVGPNAPLNDSCSTHQAGSAVSAVDNWTKAGFPANQIVLGVASYGHSFLVTPDNAFSPTGSTTLASYPLFNTTYQPEGDSWDVDAPAGTDQCGNATTGGWDGLWYFRGLFEAGGFLTGNGTVASGIDYRFDSCSQTPYVYNPNTEVMVSFDNADSFAAKGNYIKQAGLRGFAMWEAAGDYEDILLDAINNAIGVQKVSTFDVVSYTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4H2</accession>
    <name>A0A401H4H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620259.1">
        <property type="nucleotide sequence ID" value="XM_027764458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4H2"/>
    <dbReference type="GeneID" id="38786263"/>
    <dbReference type="InParanoid" id="A0A401H4H2"/>
    <dbReference type="OrthoDB" id="3269308at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18187" checksum="A0762C4358811833" modified="2019-05-08" version="1">MLHRSLDLYPLLIVDNKPATVWLIGEVDSSWFKLRGEPLAVVSIKISSNTSDVLKASRFQSTGSGEYASVEAFQDVFDADTKFGPRNTMRQMHATDIHKNDLVLVECNITHWRVDAKGKASYEKGWTKWRTGFELVTIARLYDGPQEIRAVVPRAKVSSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4W3</accession>
    <name>A0A401H4W3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1600510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620303.1">
        <property type="nucleotide sequence ID" value="XM_027764502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38786307"/>
    <dbReference type="InParanoid" id="A0A401H4W3"/>
    <dbReference type="OrthoDB" id="3192989at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="7">
        <location>
            <begin position="176"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="8">
        <location>
            <begin position="611"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1600" mass="180634" checksum="7D1EA570A7AC25EC" modified="2019-05-08" version="1">MPSTLLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELERKWPPPFGESEIRIDQPATLVDMHGRILAWILPRVLIPDCQTKMLQATRALHPAIAASKPSSTTASWRHNPLYFLPPEECAQFPAGSLCLSPGWFQQPLQHMESGRLETSASLKLEGRSSWLHDIHDSSTLLGAILAVVHPTLYAAGRQCLGLIQQDSELREMALNWSSPFNVLQVIANRETPFHRDSKTRYTFYDLLATLGNYTCAWLKFPAMRVAIDYSPGTVIAFCGKAIHHGVTRADGERLVYAYFMREGVQNRLGIPAPHWMDIMPKTDGDENTMQGMETVDGSFIGGTKLAEVMAKLRVAWLADLEVGGGGGKMYSVEKLCNKSRLVVDLDDEVEFVTKVAKQTTRGVRYVDVPLPMPTGSNVPSPSKSPSKAPASGSLFNLDDGDVLGNIGVLIQLDPVARKTKTQNDFMRDWIPHRDDYLHAIIEMEAPPEPRNCAECKVGEGRWRCLDSCSFPSDRALAGDPCPLGAFTAHNNPAPVVAPGSNFWNASNEDLNAHDGKVSDDGEVPFNFAPLAGTLDGEARQIDDAPDPTWEEDVPPVLSRPPRRDSYGNRIIVIVDISGVHHISIDWCQCEMAVERDMQLLQMGLYPGTVKDPHTAFTFAVLDDFLLENKECKTAALNYYSKLKRVTSNAFAGTVPDRYRELMRVSRQWRQLKYCKWHGFSHDALHPVEKGGLAIFCPACPQPELNLPFDWQADPVQWKFKCGFVMDGNFSAEHMKMKHPEEDVALSDGQAFMVGQEDYKAHLAVAMESHQRSTCHEHRAVNQANVDRANLDATGIGATACARHGFFVPHTVVDFQKGERQMNMDYSLSNALLTLTGITLVLVMYDIMCQYGVHVRKRFRHSAYLRMPFELKIDQGIGLFHVHGHQDCCFQRFSPNFIVGAGMVDGEVIETLWAPTNEVSGSTRGMTRAHRQEVLDDHMNDSNWKKTTRMVPTLMTKWKRVLLGFPRSKESFEALSASTDEEVLEAWQKEYDDAMEARQNDPKIMDTFDVQLRKAPGKDLTQLRLAGEESAKGLEKGTAGWLSTGLKIQEAQLKLANDIRKAGQNPSMAEDLKTLERRQRLEVSILTFQRRSEKFMGRLEDVPAMEDHDDGALWDSLDENPFQIHPEDAEYGEDAIPPEQASLNLPSQIGFVAAVTNRLQTLAAQELELRKGLMNDILHELRMALGLKSYLYRKRVRPANSVRTMTRAQAEVHAADQTVLACTRLYSANRHAIMRLGATDEDLALYRPLDKKDLHVKTAVIEASTSGLRNVNLAWFWTMDVAGDRGSSEWMDEFYRVNWLRARARYERWREERVLVHSEMAWTIATFKRNAERWAHWLEMTDPSWRGHVCYAARQSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVRWEEGLRREMFAVRGICGDLALAGHADHIDHGGVIASVLTVCTFNREVLRPISIDVKAIPRPTTLVPHPKNLLEDSPDYWWKWDHQVGPAGSPMEAWWYKLGDPWEKVYTVSESTLVQLEQLHVRVANLTSWLHERTDQNLDVVLEELQEATRQLRELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5F9</accession>
    <name>A0A401H5F9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1602820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620532.1">
        <property type="nucleotide sequence ID" value="XM_027764731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5F9"/>
    <dbReference type="STRING" id="139825.A0A401H5F9"/>
    <dbReference type="GeneID" id="38786536"/>
    <dbReference type="InParanoid" id="A0A401H5F9"/>
    <dbReference type="OrthoDB" id="2672960at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="222" mass="25079" checksum="0CC7E7506A330019" modified="2019-05-08" version="1">MPGIQINPASLECPDYASDTYAATRAPLVNDHTTNEQAIQLLVNIWKAGNDAEKVSWQHQMEEHEAEVAEQVRLAAEADNDAQEAQLAEQANVRKEEIKKNRAKFAPIPDRDVPTIAPVIAANYAIKRMERGDFVELWYYMNEGLEEALRITSSVDDEATVMTRTSDGSTSWVPAGSVREARGVTDDKDIRWEDFCQAVPRMVLAMEQARWPEERITMLARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5M6</accession>
    <name>A0A401H5M6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1603240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620573.1">
        <property type="nucleotide sequence ID" value="XM_027764772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5M6"/>
    <dbReference type="GeneID" id="38786577"/>
    <dbReference type="InParanoid" id="A0A401H5M6"/>
    <dbReference type="OrthoDB" id="3353107at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="115" mass="12965" checksum="57E7CFDB5F24548D" modified="2019-05-08" version="1">MQDSRPGSPRDMFAFGMVQEGSRGLEQFLEPIDDLTGESLDDFGVGWGTHRDDRIMSHFFEHNPIESATFTPSLVELSQPTAHEEKTEAKKQVTALCWQPILQRLDLFASTPSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H654</accession>
    <name>A0A401H654_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1701990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620786.1">
        <property type="nucleotide sequence ID" value="XM_027764985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H654"/>
    <dbReference type="GeneID" id="38786790"/>
    <dbReference type="InParanoid" id="A0A401H654"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="15834" checksum="1B7AFDDE5EA73616" modified="2019-05-08" version="1">MGTKTSDTSSDTPLMEYPRPLLARRQNQFPFDLALLVRTYPVDDLRYPNHLSRLHPLLRVAVIPTGMDVSPNKDHEPAGGHATDVEEIIMSATAPDDDEDHNISCGTRNVRRELMLQRSPLVAHLFFFFSLFPLRYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6R6</accession>
    <name>A0A401H6R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1801490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621038.1">
        <property type="nucleotide sequence ID" value="XM_027765237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6R6"/>
    <dbReference type="STRING" id="139825.A0A401H6R6"/>
    <dbReference type="GeneID" id="38787042"/>
    <dbReference type="InParanoid" id="A0A401H6R6"/>
    <dbReference type="OrthoDB" id="4230923at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="32025" checksum="2CB8B3DC9D9F9553" modified="2019-05-08" version="1">MKSFLEHFGDQVSRVKAHMYSVLTEFVPVACNPDNSGYLRVIEGSNNLNPNVIEEARWIKPPERRAKGQKVAHLIVRFNNPSAANRAICNGLVIASKQVSARKLIREPRRCLKCQQIGVPHLASDCKQIHDTCGNCTSISHKTSACEADPTDFRCSNCIRAGRANADQAAWDHDCPVFLEHCHRMEDHQPEAKYHFFPTEDPSTWELTGQPLLQAAPPRHRTLAPVPMEPPLQNWADEADNLHPQPNLFPRPSQARWASEARSSQDASQPWPQLHQMFIHRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6V1</accession>
    <name>A0A401H6V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1801680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621057.1">
        <property type="nucleotide sequence ID" value="XM_027765256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6V1"/>
    <dbReference type="STRING" id="139825.A0A401H6V1"/>
    <dbReference type="GeneID" id="38787061"/>
    <dbReference type="InParanoid" id="A0A401H6V1"/>
    <dbReference type="OrthoDB" id="3263285at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="315" mass="36129" checksum="5BDC1DF4BB1CA931" modified="2019-05-08" version="1">MFARSVRWFGASATPRLKTSILRHIRIRPSGAVGHPSKPADASANDHKEGESFLKMLPDDAQRNFVYEPVYEHPTARWSQVPDVPPLPPRPPYPCPFLTQEDITTYLVPLYHHGWIIGNAEVLADDCFDITNSTNVYVPQLGKLFEGFVKEDSAVAFAKALKDLQNREKHHADVCRTSNTVQVLMHTHTALPPPRAADDAVPDMERVCPGLTLRDVHLAIGIEKLFAEFRERGEAKGWSQVSLHPVRFQPHTPEEIKEYGRMPHRKPRETYSTRQSREWMRKMYIRREETGKMHGGSDRPVRKPAKKKRRRSRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6W4</accession>
    <name>A0A401H6W4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1801340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621023.1">
        <property type="nucleotide sequence ID" value="XM_027765222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6W4"/>
    <dbReference type="FunCoup" id="A0A401H6W4">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6W4"/>
    <dbReference type="GeneID" id="38787027"/>
    <dbReference type="InParanoid" id="A0A401H6W4"/>
    <dbReference type="OrthoDB" id="10261212at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="387" mass="42925" checksum="02F68BEA2FF66245" modified="2019-05-08" version="1">MSNQEENGVQISVEELWYLKDITFRLSSDSPPKQVKIVTQNFNGPCSFIAICNILILRGQIQILPAERTSVSYDFLSHLVGEWLLAACQDVDISAALSTMPITRKGMDLNPLFTNVTSFRPAGAGGELKLFEQAGIKLVHGWLVDPASPEHQVLAKTEDYDTSINLLVEADHLTKGKLVTTEHFTPASPTEPSPEENLSPEDFQKIEDAIVIRNFIESTQSQLTYYGLFALASSLEPGSLVALFRNSHLSVLYKAPGEEAALYTLVTDQVFLHEASVVWERLEDVDGGWSTFVDSDFVRSSPAGGDYAGHTGESALAALEAQAAGMTIEDDADQQLARQLQAEEDQRAQEIYEQRTAERSQREREALRRLPAPEHRQKKKKTDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6X9</accession>
    <name>A0A401H6X9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1900570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621121.1">
        <property type="nucleotide sequence ID" value="XM_027765320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6X9"/>
    <dbReference type="GeneID" id="38787125"/>
    <dbReference type="InParanoid" id="A0A401H6X9"/>
    <dbReference type="OrthoDB" id="2955493at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019069104" evidence="1">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14664" checksum="F3374B20E9609883" modified="2019-05-08" version="1">MRFKTLAALLYSSLAFRTVTVLGLGAARSLPHTDITYPDYDAIIVCSSLNCTELCDAVSMGSLNTCYNVSSINYLREYESIMTYICPGCNYAFPIYMATAGCTGTPVQLELNVCYNTSYGGEFEYYQTYCISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H7E7</accession>
    <name>A0A401H7E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_2000030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000020">
        <property type="protein sequence ID" value="GBE90260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621173.1">
        <property type="nucleotide sequence ID" value="XM_027765372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H7E7"/>
    <dbReference type="STRING" id="139825.A0A401H7E7"/>
    <dbReference type="GeneID" id="38787177"/>
    <dbReference type="InParanoid" id="A0A401H7E7"/>
    <dbReference type="OrthoDB" id="3238562at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE90260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="35447" checksum="B62C1A549723E5D8" modified="2019-05-08" version="1">MPLQYRSTSTLVEEHTDAINCVALSPDGLFVASGSTDKRIVVWSLSSGQAIHRLVTHSAVLSLLWRSSPSRIICGTADGTLITAAFNEENIYVSGFSAHSKPIECLSLSKGTTASCHLATAAHDVVNIWSSVENDTYWDYGDTLDAPPSTPYSASHSVIITSVQWMNDPSADCLVTAYLHHGIICSRRGTGSIEVLWSIHLPLCGACNISPANDTLAVCNITSGFDVYAIPSGLRRLVLEVPSEPPGMALPIVYIHKGTMLLGGASNGKVRLWDARSGDIVQTLRYHGKFDPLLIQCVAENPDTFLLATGSSDPGVPNSIQVWELRDVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4N2</accession>
    <name>A0A401G4N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608059.1">
        <property type="nucleotide sequence ID" value="XM_027752258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4N2"/>
    <dbReference type="GeneID" id="38774063"/>
    <dbReference type="InParanoid" id="A0A401G4N2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="126" mass="13260" checksum="0C1B42E5BC939F1C" modified="2019-05-08" version="1">MQHLFGSSSFTSRVAWRMATEYRLRAVAVRLSASVVDRGDDGTKNVQAVRSTKLIVGDIAIRDIPSTTHRVVVPHLAQLAAQLPASPNLDPPRSAPDDSGGVVSQSGGGLRRCALGMGGRAVGPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4T5</accession>
    <name>A0A401G4T5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0100470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608088.1">
        <property type="nucleotide sequence ID" value="XM_027752287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4T5"/>
    <dbReference type="STRING" id="139825.A0A401G4T5"/>
    <dbReference type="GeneID" id="38774092"/>
    <dbReference type="InParanoid" id="A0A401G4T5"/>
    <dbReference type="OrthoDB" id="2642524at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="510" mass="56713" checksum="82FF04BB4272480A" modified="2019-05-08" version="1">MQASHPSDTWHLTIVCTKGLQFVRPEKSWRPIVSVFVMGNEQTHETILGSDGQNPNLKMPLLLRDVGIESKLDIRVWHKSHSKSKNRKKRHLVGSVYISLGELLKKQDSPGANLDLRLSCPGPQKKSPTVRGRQLHYAVLTVRLHPPSYLITPPSSAALHASSSSSSSSNVSDDDSEAASDFDVDQAPPSGEACNEELKTDSVDVGNQLRRRRRRRIQGYRIGSDDDPCTSVSCESSGPSTPHEEYFPSFREDDSFEDNSFEFNDSKESGGWFSSMMLPRYVDQISMQTPLSLAESILDIFTPYRELQEATLECDFEKVLGRLLTEWYVVGASLLALAGIDAAVFGFNPGTLFDTDGAMQRVVAFGAISAGLGIVFDAWFLFLYSGANATKFQKLATDVYNSYFFFCLTCRLPTLFMFLSAVALMVFLLGVAWTRWPTAVLVMSCVAGTLISLQYLVFGFHRLWNFGIWCGRSIWWVVRGRRAFAESCVSSQEQPAPETSPSRARGKSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G519</accession>
    <name>A0A401G519_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CDF manganese transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0101220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608162.1">
        <property type="nucleotide sequence ID" value="XM_027752361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G519"/>
    <dbReference type="STRING" id="139825.A0A401G519"/>
    <dbReference type="GeneID" id="38774166"/>
    <dbReference type="InParanoid" id="A0A401G519"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF12">
        <property type="entry name" value="CATION DIFFUSION FACILITATOR 1 (AFU_ORTHOLOGUE AFUA_1G14440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="118"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="8">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="406" mass="45369" checksum="B688F283E57927EA" modified="2019-05-08" version="1">MVPVKNTEHYTLSTRAGVLQPDTANTDGVVPDLLYRSRNSNDVERVPAHQHPDPFSLRNGIKTEEELAVLRRNAGKKVERYQRKQNNLITYLLKTMDEHTEEAKSEEQAARLPVKIAIWASLVANLILCILQLYGAFSSGSLSLIATGVDSVFDFGSNVMLFWLHKKAAELDVNKWPVGGSRLETIGNVVYGFLMGAANLVVIVESVQTIVTHSSKNDTNEFHIPSLVAVGAALGVKFVLFLYCMSVRKASSQVQVLWEDHRNDLFVNGFGLLMSAGGSRLRWYLDPVGAIIIGVGVILAWGREVYREFELLAGKSAPHDFMQLLVYKTMTFSDEIDKVDTVRAYHSGPDYYVEIDVVMDGNTPLWKAHDISQQLQDKLEVLPNVGRAFVHVDHETTHTPEHRKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5G8</accession>
    <name>A0A401G5G8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0102810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608321.1">
        <property type="nucleotide sequence ID" value="XM_027752520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5G8"/>
    <dbReference type="STRING" id="139825.A0A401G5G8"/>
    <dbReference type="GeneID" id="38774325"/>
    <dbReference type="InParanoid" id="A0A401G5G8"/>
    <dbReference type="OrthoDB" id="3330034at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="236" mass="26693" checksum="03F3CE5A7F3DDD7C" modified="2019-05-08" version="1">MSFPCFLPYANGEEYLSAAIVPPSLCEPEDEFEIDPCQAVFLEDFRKEISKYTTRELAGSVPNATKVALIESFQQDWKNCARLCVEKTAETLRCELDALILVYFSTFPLLRLDVTNIAAEIVDAASQKALDLVLKLFQLETTPRVGSNMELRAIKYRFAQRYDSMRRGMADLQPYNTELSVMAEIRAYFSISHQRFISNVLAAISSELVDVISGNLEESLFRELGINSHYLDEGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5J9</accession>
    <name>A0A401G5J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0103150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608353.1">
        <property type="nucleotide sequence ID" value="XM_027752552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5J9"/>
    <dbReference type="GeneID" id="38774357"/>
    <dbReference type="InParanoid" id="A0A401G5J9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="91" mass="9567" checksum="CA3D354E4DB7D7D3" modified="2019-05-08" version="1">MIAPTSYKLPALFYQVLALITMGSIFSAIGSGINAIISAIANVIMTIVSVIVTIIVTIIDVILDILCCNCFGGRTRRTGTHSYRFGGGTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G657</accession>
    <name>A0A401G657_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0105300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608563.1">
        <property type="nucleotide sequence ID" value="XM_027752762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G657"/>
    <dbReference type="GeneID" id="38774567"/>
    <dbReference type="InParanoid" id="A0A401G657"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="8403" checksum="04DA4FBC66741F6C" modified="2019-05-08" version="1">MFANPPPANPAPTRSEGDVDPFVLYTQSLHDYTLQLWTESRRLAEEKARIRAAEIAGSKKQEGRQRQRADAARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G660</accession>
    <name>A0A401G660_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0105310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608564.1">
        <property type="nucleotide sequence ID" value="XM_027752763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G660"/>
    <dbReference type="STRING" id="139825.A0A401G660"/>
    <dbReference type="GeneID" id="38774568"/>
    <dbReference type="InParanoid" id="A0A401G660"/>
    <dbReference type="OrthoDB" id="2591106at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="856"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="978"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="3">
        <location>
            <begin position="761"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1243" mass="137742" checksum="51BD8882EEA74A63" modified="2019-05-08" version="1">MSCACASFSSATEATSTLVATPFSRKERRLRRDQNVYQTPMLYIARLPITLACSATTIIIKSVVLSFLAGALPAAQAAPDQPVCIGDGVDVSSIGLFSILVLCGTTGLLLWLFFAIIRPRYRQVYGLREWFVPQGLRPKPLSRSLLGFLFPETPLVPRIPTNTNSFGKSVARDAEPFLSDEELSQRTLWTAILIVSVWTFLSLAGLLPLYMVSTPCLAESAPPARYNGVYSALQDLSLLRLLQLLDMGNVTATGWSAYEIIHGHDAAPNARIRVIILTVFAIVLALAPALFLVVREFNKLVGNRERWINEKCEDQDMGWLSARQGPGFVGWGEKRVKDFLTKSGLSSSLETNETNNGRPNRRRRNQDEEEKGKLEIDIQGLFSISDTTTLAPLIEQRDEILENLEIAESKYIQSFRLSTPDPSMVDFQPTLPAISEDPNVPFKPIISRPRPLAPSASQHRRRRGHNPAIGSSSLPPTSYMMPSQFYKIHGVQGISNGQFTNVDEDIVSPAREPTLSDSINQRVVGSRFQEVNGSSLNFDHIPLGSQVTVNKGGHLEPIRIFESPIPDSDLYGEHDSWDTAAFGEGLPYGQWHAHQSQDPILNESEEDWVDVGSEDPEAFDHGEEYPEDTRRRPRPPRNEDHRETFPLRKRIVAVDEVPPHLRLQPRQPFVRPLSGLDHEALGVIYTDINIWRSKLKSINLDISEVQRESYNDVADGARIKGWLLVGRGLRFLPGVQLIEGRAKEDIRWDELQSERDIYSKVAYWITVVMITILLGIGLTAVAGLYLSTAPNYAHYLPFLQRLGEGNKVGGGIATCLASALAAILFTTLALTFVHYANDLNRSISVSASRLFGFKTIFYILALVPGIWLFTVGSILFAIHSFSIHLSESESVGNGVIYMSAFALMLVLAVAVGSPALLMLQPLRFWRVIRTEKYAVTPRQRFRAVYPGAYNPSYALSCSVIAIMYASAFSLIFPLVAPAALLLLLLTLVAHRFLVGYVYGRTLSQTGGLLQIWLVRRTGTLLAFQPLILGLILLSRRLWVEGGILCGVALFVLAFVEGYCTWRTRQPGRDSLTAITLDSLEKFTRAARPGAERAMDQESTSLVSSARNTRTRGSYASILDMMSMTLAVAPSPSETRGPVPLDTETLDDLTATERAARTHPDAPPHLPPLPFADHAEEMAGMLYAPELLAPPPVIWLPNDVGGVGRSEAYDLQRHHDLRVTLDVRAKEDAASRRSSVRRVHVNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6H1</accession>
    <name>A0A401G6H1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemimethylated DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0106480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608679.1">
        <property type="nucleotide sequence ID" value="XM_027752878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6H1"/>
    <dbReference type="STRING" id="139825.A0A401G6H1"/>
    <dbReference type="GeneID" id="38774683"/>
    <dbReference type="InParanoid" id="A0A401G6H1"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF21">
        <property type="entry name" value="F-BOX ONLY PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="1">
        <location>
            <begin position="470"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="609" mass="68345" checksum="1C480ED8891EAA1B" modified="2019-05-08" version="1">MTASWPWLPTELYVHVLSFLPPARDAADVSAKTLASCLAANSHLRAAAHSPLLWEPHYRARYTSCVPENEERRKAAAKGDWHRMYVERRSLDHRALVILDEIRLQLGGRHQRARVFTRELSFDVWDALGIETQLSLPKCFRPEGEGGDTDDAPAPHALPRRYWARTVRGIIARRYALNLWGRITSGDESITFEEAISGLSAFFDISPMQISANLDNLADFCRSTLVDAGVELNPESSQYDLRDLVMRIRHVLHSLGYSAVTGAEFYFPLNQFPHSFMSEGHRRTIPLSLVFVFVAIARRLGIQASATNFPGRVLAYITSPDKAGGDMLFDLCGNTDPLTFTSRNVPQMLEEVGMMADAPPESVTPCKVSTTLYRAAANVLLSASRTADSSTETCVWANYAARCVFFLHAQAIFDFKSFLGSKPLDAVAVLADVLCPALTVELGDILMEHCADVEQIDERYARVRYTRTPRIKFFVGLVVRHELRDYVGCIVGWHPYAEDVDIWAGVSMIPQPDQPFYTVLTQNGGKKYVAEEDICPATFTVEVARELFNSRTAFARYFEDIELGDRQRGRMLLSHELKTIYPDDDRAGEAWVSRGVMPRVESILSKPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Q1</accession>
    <name>A0A401G6Q1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0107200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608751.1">
        <property type="nucleotide sequence ID" value="XM_027752950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6Q1"/>
    <dbReference type="STRING" id="139825.A0A401G6Q1"/>
    <dbReference type="GeneID" id="38774755"/>
    <dbReference type="InParanoid" id="A0A401G6Q1"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="19"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="230" mass="25509" checksum="2397D4C5C74338AC" modified="2019-05-08" version="1">MDDIDAIPSISSGNVGSRFVSQNDIETAKAKREEQWKAAYARLGQEPPPPPTEDVFDGRSLAEKLAANRAAKQEEWEERNKLGNQFRALEEDEVLFLDSIMEKQREEERMRKEMDGEELKHFREAVAARENEANKPPAISSIVGTTTSVPSKPKAPAAAPSARKDTKKLLKGVLVKKKPRPAAGSPPVTNNPKTEGTAKVQSQSTNGSERRKVEDLERPTKRPRLSEPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7W5</accession>
    <name>A0A401G7W5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0111350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609165.1">
        <property type="nucleotide sequence ID" value="XM_027753364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7W5"/>
    <dbReference type="FunCoup" id="A0A401G7W5">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7W5"/>
    <dbReference type="GeneID" id="38775169"/>
    <dbReference type="InParanoid" id="A0A401G7W5"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000158">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="50218" checksum="6E4826AEA99B5F4D" modified="2019-05-08" version="1">MDEEYDVIVLGTGLTECILSGLLSVEGKKVLHMDRNDYYGGDSASLNLAQLYRKFRPDQSPPAELGRDRDYAVDLIPKFIIASGELTRILVHTDVTRYLEFKQIAGSFVYRDGKISKVPSTEMEAVRSPLMGLFEKRRAKRFFEFLQSWRNDDPTTHQGIDLDKDSMNAIYEKFGLEPGTQDFIGHAMALYLDDDYKAKPARETYERIILYTSSMARYGKSPYIYPLYGLGELPQSFARLSAIYGGTYMLDKHIDEIVTDAEGKFVGVRSGSETVKAKQVIGDPSYFGAGKSTDGGKVSVVEECKVVRAICILKHPIPQTEDADSAQIIIPQNQVGRRNDIYIAMVSSTHNVCAKDVYVAIVSTIVETNRPEQEIAPGLSLLGPIYEKFVSVTSLYTPTATGEADNIFITRSYDATSHFETVVEDVNDVWKRVVGKDLVLKKREVEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G831</accession>
    <name>A0A401G831_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0111870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609216.1">
        <property type="nucleotide sequence ID" value="XM_027753415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G831"/>
    <dbReference type="GeneID" id="38775220"/>
    <dbReference type="InParanoid" id="A0A401G831"/>
    <dbReference type="OrthoDB" id="2688840at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="427" mass="47558" checksum="ADEABFCB23AE7CB8" modified="2019-05-08" version="1">MPHGDYVNQRSAAHLYKRSLPRTRCKPSSQSFPTLCMSSPVRRQLPRLRSQSASSPIRGIQYTDDSEWRTATKRARPSHRRSPSLHDLPSDELPENRGMDQRLRGKRARRDTADEQCALPSGSRMERSGTAHTPASDLASTSAAFQLYPHRQKKGRRTAHHGLHRTESVIRRGGERRPSNDLHRLRSDAFGELHRSVADSGEGLVRRMRDWEHSRRIPTAIPDHYNGLPRRRDARWSYYAPVTPDVEDEEVEIVSAAPDMYLHTRSPSHKKRAYSLGMMEVDMPDILPPFSPTVGSEGYSSPIDVFSGISVCSSDDEELFPTDQPFGFSSTPELSHTYTNSANSSLISLPLSLSSPHDPSHHPYANRTVDFLDPQSVHVPSSASEKAVDALILAMANGAGGVNDYEALRQAEGSSSGEPSDVGELWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G853</accession>
    <name>A0A401G853_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0112410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609269.1">
        <property type="nucleotide sequence ID" value="XM_027753468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G853"/>
    <dbReference type="STRING" id="139825.A0A401G853"/>
    <dbReference type="GeneID" id="38775273"/>
    <dbReference type="InParanoid" id="A0A401G853"/>
    <dbReference type="OrthoDB" id="3192989at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19844" checksum="14E4B3F7C73AB255" modified="2019-05-08" version="1">MLMIRQWRHVKMAKHAGRGHDSGGISESRAGVLAVLCHACPHPGINLPRGWDDTDGSDRWLYTLFISHNANFRLLNRVHAHDQRDLWLAPGLAYFVHNEPYADYIKKFVDQEEIRTCIGFAALMNSLNWKAKGLQSMGVGGKGERYCNMDYIFLSSVKSMDTKRLVIFYDIACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8T5</accession>
    <name>A0A401G8T5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0114570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609481.1">
        <property type="nucleotide sequence ID" value="XM_027753680.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G8T5">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8T5"/>
    <dbReference type="GeneID" id="38775485"/>
    <dbReference type="InParanoid" id="A0A401G8T5"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1826" mass="205870" checksum="2E65015D3AD874CD" modified="2019-05-08" version="1">MSGLSSFFPTKLLSSMHRPSEPLSRSDPLSRLRFALETMPGSRKYVFTPATRAEILSELYDAFWGPYAHLFLPNSNSSLPLHATLSEVQVSSGSQKELPPVPGRPCGHIFKKGESCFRCKDCALDDSCVLCSKCFEATDHANHNVSFFIAQQSGGCCDCGDIEAWLVPIDCPFHPVSPEVAEYLSTFIAGTLQTPPRTASKVISAQDVSPVKDYPLRVSVPPELRDTMSRTVAYALDFVLDTLDYSPDETYVPATEIDLRAQLSGDPMMRDQFCAIIWSDDKHSFEELTQLLRDLANRSREEASEIVERIDEQGREIVDMNSNASRLLEIAHTISQIDLGVTVRRAYDTFREQVAAVIIEWLLDLTRSRLGSDALVMREVIASELLSTRRNYALLSQQDVGKLLAGVHDPSRIDWFFLYHHKLWKKPRLNLKEIYASILSLGHEHKIAVASHFANVYTRIIDTYLLVDREAETSIKYFALQLFTVPSVALYIVRQHNLIPRLLAIIGAFFTNQIQDKRIVFPADPNAEIDVDTFPFKSKRFMPVFSDLRYLCHNEPVQQLIAHNREFITQLCKTCQIFMCVNPNKRAVSSHVEYETDAWISMFNVTLSLSRVIKVYGEAFSRATVAELVAAITTVMHHILVVSAVVDDQRDITRFPPVVFHNSVFGDASYQIIDFNVMEGWVSFHHSLQWFLAELFKHIDILSEDSLQTIGMSSLRDVCLCNASEQAILTIIDYPLRVLTKVAQIRTGLWVRNGFAIRGQLMHYRDFMLRELCYDQDLFLLQSALVILDPNTVIVSMLDRFQLLGYFSGATLHPVFDSSQLSSMVEEFLYILITILTETATATKLSLPSAIRREIIHALAVGPCTFTDLTKRVTERMVDDVSFERVLKEVANCRAPESGVDSGIFELKDELYDEVDPFFYHYTRNKREDVETTLRNRLKKATGLDDPVVVPRPVAITNGPYVALQSVFQSEALLQILFYGIYNILTLTDAIGSSPGSAEAILDQLMYLIMVAVIEQPQVFSGLVAHKPFEEGQTLLDMLCKFECHDSYKPYKSRSGWILQHIAEHQQDEVLKRRRMVSASVGEVADPVDAKKRAAKARQEAIMKQMKAQQAKVAFNLEDVEDEENEDISTTPDVPMSYGTCIVCQEELNSSKAFGSLGFIQPSRLLRRHPDGHHVHINEALLAPQSLDRSLGVVPMPSFPPSETEIRDSKARSSHNFDAFPSQYTRFGLHASICSHMMHLDCFNVYCSSIRQRHRTQATRNHPENVQRKEYICPLCKSLGNVILPVGMGLAATELNAVSFPDWIRAAGINILKSKPDPVLESLQFRSGTGEFVFWSAQDLGFQSFMRILDRPGPVNTDTYKMVDTVVGIAKTISQQTRHLRDRPEPDLGERGAGMYLPEELVGYTIASFEVAQRGSGFAGYTIADNLSDSHYGVIRGLVACLTKLVAWNFKGRPDEGCDAVRQAIIKRLLPEWSRTSLTSFAFPLLLRDPFAILVETAAVAPDMLRHVLILTYYACLARTVIGLIYVLNKTRSYHASTIVQRSHEDIFGDVQMFFMSVVRHSPVFEQAADMAFQAFGEARIEKLLYAYTLPFLRRAAILCRAMVPTGFQIRASGGDACEYRRLLEMLEIPPLSDLPNQDTLQNALSGWCGHYGHSHAASQLNCGVVLDYPVVYHLARLPLVLDNLYPEQDKLMTCPRCHTVPLDAAICLICGTTCCMQSHCCIDYDNQSRGECNMHTKECAGPVGLYFLVKRCSLLYLYANNGTFGQSPYLDNHGEVDISMRRGRRQYLHHVRWEDVRKTWLNQGIPTLIARRLESTVDSGGWESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9P7</accession>
    <name>A0A401G9P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Retrovirus-related Pol polyprotein from transposon 412</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0201030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609819.1">
        <property type="nucleotide sequence ID" value="XM_027754018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9P7"/>
    <dbReference type="STRING" id="139825.A0A401G9P7"/>
    <dbReference type="GeneID" id="38775823"/>
    <dbReference type="InParanoid" id="A0A401G9P7"/>
    <dbReference type="OrthoDB" id="5599163at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13975">
        <property type="entry name" value="gag-asp_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="7">
        <location>
            <begin position="670"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="815"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="921" mass="102648" checksum="75FCAEEA0F641969" modified="2019-05-08" version="1">MPSPDLKKSTPAFIYESKAAVPNAAHAIFSRMLDVVVPNVTVGELLAVSPDLCKEAIDHSRMHRIATAPQSALSAITSLTLPSVDHATPLREIAVSINGKLVLSLLDEGSEIVVIQQDLCEELGLHINETMRMNMETANRGKEPLPGCVEMLEINVEGIRTWAHAYVVPNAPYRLLLGRPWQKHARLHKHEFEDENVFITVHDPCDPTNTRDLSTKPRLIGVPRGSFALTVSSAAVRSDVILPTISGLTDTFLADEVLRSNYEWDPVAHVFAYKKVANKVRPIVTAMPEYARIERCIPKDPLATLSPLSPHPPDFTPGTQLSQERMDNLGVLISDFLWPEEQKLIAQVLKQNETDIAWDESEKGHFRDEYFKPVIIPTIPHTPWVHRQPPIPPGIREEVVKLIQAKIKSGVYEPSNSAYQSKFFCVAKKDGSVRIVHDLQPLNRVSIQDSAAPPYVEHFAKQCAGCSIYTMMDLFVGFDHCTLDPSSRNFTTFQSLVGTLRLTVLPQGWTGLPPIFQGDVVWILQDEVEVAPNFQDDINVLGKKTRYELNGGEYEVILENPKIQHFVWEHAQDLNRVLHRLKHAGATVSGKKLFPDREEVIAVGQCCNYEGRAPDNLKVAKIVKWPACTTKSEVRGFLGTAGTVCMWIKDFATIARPLVNLTKNDTPFEWGPAEQESMDLLKDAVVHSPAICPIDYKSDNEVILAVDSSHIATGYILLQLDDAARRRPSRFSSITWNDQESRYSQAKIELYGLFRSLKAVKIFIVGVRNLTVEVDAKYIKGMINNPDAHLNATMNRWIAGILLFNFKLVHVPGPKHRGPDGLSRCPRAEDDAEDDGEDSEEIEEWLDEVLSCGISIAGGLADGMIGIPTEEEGQKEQTGLVLTAGSHAHDAHDDIIIPPSTTSQCDDDNLHRIQHYLRTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAD2</accession>
    <name>A0A401GAD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0203430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610059.1">
        <property type="nucleotide sequence ID" value="XM_027754258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAD2"/>
    <dbReference type="STRING" id="139825.A0A401GAD2"/>
    <dbReference type="GeneID" id="38776063"/>
    <dbReference type="InParanoid" id="A0A401GAD2"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="184" mass="20265" checksum="FA660C6CB151ADAE" modified="2019-05-08" version="1">MAIINPTQLVDEFKKSGEFDRLRRELLSQFRNGEGIASFMARVEDITRQKLASDQKLQYMPDAAASRELMQELDRYPIVERAVADVAMLSDPVFATGIRDSVKKILSEDRKVTSEIAPQTDANAPDVFRKVGCQTSNQSPPIPAVEGESRREGMDAVRAVGGTAEHAPPAHEQEEMDANAALPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAS1</accession>
    <name>A0A401GAS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0204680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610183.1">
        <property type="nucleotide sequence ID" value="XM_027754382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAS1"/>
    <dbReference type="STRING" id="139825.A0A401GAS1"/>
    <dbReference type="GeneID" id="38776187"/>
    <dbReference type="InParanoid" id="A0A401GAS1"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="191" mass="21151" checksum="FBF6CEE9E10A0418" modified="2019-05-08" version="1">MVFVAWHLAVAKYRTTGDPSTFAFMIQNFTVSMTNIRAGRIWTLLTCCFSHKDTAHLLFNGLTYSFMAPDVMALLGNTRFLSLYLGGGLVSSALSVWWNHSVKKRDEPYGSHGASGAIYGIISFFACLAPTAKFYVFAVVPIPAWAFVTGIFLWDGFSAVYEKRSGVDTAGHIGGILAGIAYYLRLRYRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAY7</accession>
    <name>A0A401GAY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610230.1">
        <property type="nucleotide sequence ID" value="XM_027754429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAY7"/>
    <dbReference type="STRING" id="139825.A0A401GAY7"/>
    <dbReference type="GeneID" id="38776234"/>
    <dbReference type="InParanoid" id="A0A401GAY7"/>
    <dbReference type="OrthoDB" id="2537141at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="873" mass="95162" checksum="5557A0F68BEBF979" modified="2019-05-08" version="1">MQRADKVLHGVASLNADNLRACSSKVDKDRLLADYVRSQKTFVAVHAAQGRAVTAEWEHRLEEEASPAISALSEAPAEPDARSQTPVLKPRVPERKQKGEINKPAVSCTSRARKNAKRLEHCNAASDKDSDKENRATKIRQPIALASLSSPPQKIPSLKKKKESKLHEVSKALTKKSTKKRPRSPESENDEHAARLAERRERRRVKKAIVDPDITMICTSSGEERKQSALRGKKRSKAKNPKGVSMSAGLALMHGFSATNIGKNRLTHKLDFVTGVFNKGKASAKVAVKKPSERKISARIFSESQFLSKTRPIDQDAALASNESSSLSDSASERSLDVRTSSELPILEADNPKGKKKISRKKNHVARVTEKVSTGSLPVKRRKREDASVIWDIELDSKALASASASASDTSANPGDASITLNTRASKWGEGKVAIPTHSPSRGSMGGVNAVDEDSSLVEDRKGGFGIGKDSSLDLANPVLGRSSPSLGPSQSASQHCLRVPPAVSPFIPDTVSKFFAPAHDRKGLDEVHRASHENTAARVEEFLSDGEELPVLTAPPIESLKTLDHPMNDMQAMSPTSNVDRPSLPHHILSSPVSVDTLDRALQTLDADRFPVCADWPEAMTPQRYGAPSFRNDMTRVDCDSEDPGDHAHSDREYEGLQRIFAQMTPGSFHGDQNTQLYYSPNYGHSAEMHVIHDSRYHQASASWLSDAADYDDDLVSEIEEDVSAYTQHGSYSLASTCVPIPVDCELAPDRANYSVSAPFSQMGDFDPGFDSRFPHSFQDAAEENVALETQSSWSSCYSAVEPSDEVDGSLRSTESATVALRHFSQGRALLLGMADEGNGRAVVAEQRTVGFDTAEQAVARSLRGHWLPQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB53</accession>
    <name>A0A401GB53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610308.1">
        <property type="nucleotide sequence ID" value="XM_027754507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB53"/>
    <dbReference type="GeneID" id="38776312"/>
    <dbReference type="InParanoid" id="A0A401GB53"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="417" mass="45642" checksum="D8466F0A6F99ACAE" modified="2019-05-08" version="1">MLSQHKDIYPLSRECPPFLLPSSNPISVQILSIENIICLELIARLADEEMSDLCQISITISESGSDSRLRQESVFALSKPVEFNTTTNTTQTNHGVDILSSLNIHIHVHVHQAAVSAFKYDPPSLHLSSMKASHRNIVLSSNLRHLHPSHSISSSTPYTIINASHYPIHTIPTSTEASAVAHANIVQPSSSHSTNVHEDRIQAAPMPICGQPEVDSQEGQDNNEEGHDVQAGRQELWHELFGEKPEQTAVENVGARDGMAKEILGAANRSMNVAEPVPLDKTSTKWPRKGGTPSKAKPIQGGPGARHAAGWAEKIIVFVRQVKIAAKTNGVHPPLDPSKISQILNDVDEAKHNLSRDTVKNSGIGKAIQHLAKCKPYATWNEKELKLVERAEGIEWYWRKCCKGKWAGVGRGSGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBF8</accession>
    <name>A0A401GBF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0207100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610423.1">
        <property type="nucleotide sequence ID" value="XM_027754622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBF8"/>
    <dbReference type="GeneID" id="38776427"/>
    <dbReference type="InParanoid" id="A0A401GBF8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="283" mass="31277" checksum="8E07C93A6A1FF192" modified="2019-05-08" version="1">MHSQSGKRAQSAQPAHQTSTPQSGVRQSPSNLHSILEDLATVGICQDRHQAFNLDPANQPIGGGISYRRSVPPAYSPGRTSQKDRPDSTVRSPMPHMTPQEDAMSQSTPSVDEMMDVDDWKQFQSRGSGEDRGSLAHRGSYEDADEAGQLKGEILDDDSDRGDMFVVNRDRTGSPPLSNDESEETDELDNTDEELEETIHQPRSYTPVSDVEEDIEEEGKEEDKNEDEDNDEDEDNGEDEDDDEDEDERSVPVQPSPVFQSRPSHGVIRRPKGCASAAKVDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBK2</accession>
    <name>A0A401GBK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0207390</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610452.1">
        <property type="nucleotide sequence ID" value="XM_027754651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBK2"/>
    <dbReference type="FunCoup" id="A0A401GBK2">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBK2"/>
    <dbReference type="GeneID" id="38776456"/>
    <dbReference type="InParanoid" id="A0A401GBK2"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000059">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="300"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE79539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="627" mass="71270" checksum="06897A8F5213DBB4" modified="2019-05-08" version="1">MPTVAVDKEDLWRRLGRAYTTEEFDRLMFEFGLELDEDTTEEVEAARKKGLPVERPQLKIEVPANRYDLLCIEGISRALRVFLGLDKPPIYKLVYPKGGKKDLITVTVAPETKQIRPYFACAVLRNVKFTQLSYDSFIDLQDKLHQNICRRRQFVAIGTHDLDTIIPPFRYEARPPKDIKFVPLNKNKAYTAEELMTLYESEKHIARYLHIIRDSPVYPIIYDTKDRVLSMPPIINSEHSKITLNTRNIFIDITATDETKLAIVANILTTMFSEYCEEPFAIEPCKVVFPDGTTRITPDLSYRPATAHASYVNSCTGLKLNATEVASLLERMTLHAAVSSDPDVVDVQIPPTRPDILHECDLMEDAAIAYGFNKLPDTFPPTSTVAQPLALSKLSDIVRKEWALAGWVEVLPLILCSHEENFEWLNRVDDGTQAVKIGNPKTLEFQVVRTSLVQGLLKTIRENRSHPLPIRVFETSDVVFKDTARERQARNVRHAAAVWCNKTAGFEVVHGMLDRIMQMLEVPRIAGTDVKAETGYYIKEREDPTFFPGRAATIYYRAPPPEKGTLSALKRTVNAVVHTPGDEEIGLLGILHPSVLEKFEIPYPCSALEFSLEPFKWEMHELWTDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC57</accession>
    <name>A0A401GC57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0209550</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610667.1">
        <property type="nucleotide sequence ID" value="XM_027754866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC57"/>
    <dbReference type="STRING" id="139825.A0A401GC57"/>
    <dbReference type="GeneID" id="38776671"/>
    <dbReference type="InParanoid" id="A0A401GC57"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="227"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE79754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="347" mass="36883" checksum="77299834E4E1A0E4" modified="2019-05-08" version="1">MAPYILDPSALISALPKVLPPTKQRLESPQDAIAALIHTAMITLGFRLVAVDDISPARSILNSVLPEEWNQHGPGNYTFRYRHEQSSLEFVLKVVRLGSRTLINSVAIESDKAAALDISTNDFTSPSFFPHDLSAPNAQPLVHGFISSNRLEDLMSQFKLTTVQKLVPGLRKEGYTEISSSSGASASTSQPRTDIPAPARPVPQSPPQAPERFVPPYSSPAQGIPDIGRRDLDPIPRNPFSPPSLFPDNAGDGMYVGPEHPIFGPGIRGRGPGGRGPWGGDGYLPPMGAPPGARFDPVGPNLGPLPGGPPFPSPGTFPRPGRGAFPGSGQEPDPDEFMPPGAGDMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCA7</accession>
    <name>A0A401GCA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0209930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610705.1">
        <property type="nucleotide sequence ID" value="XM_027754904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCA7"/>
    <dbReference type="FunCoup" id="A0A401GCA7">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCA7"/>
    <dbReference type="GeneID" id="38776709"/>
    <dbReference type="InParanoid" id="A0A401GCA7"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="8"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="310" mass="35601" checksum="3AA308374074A1C1" modified="2019-05-08" version="1">MTIPKTLPECWGHRGASAAYPENTLASFEAAIRDGAEGIESDVHVSVDDVVIMFHDPSLDRTTNGKGLIREQNWYGPEGMEHLRTIKEPKQSIPTFAETVALLMKPENRHVQFNIDVKVQNTPVRLFALMHAIISAQPEWETALAPRILLGLWHPCFLPHAKEHLPYLRRSYIGVSTKVARTFFWDDCEVFSILFVELTTYDGEKFRQECKAAGKKIMVWTVNDPEQMVEAVRWGVDVILTDVTKVWLDLRKALRADFENTAAKHGRSFLWTTWWYYFPVRLLIYYVVMYRLQSSKGPFRVIEADTAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCF1</accession>
    <name>A0A401GCF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA-splicing factor cwf17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0210410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610753.1">
        <property type="nucleotide sequence ID" value="XM_027754952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCF1"/>
    <dbReference type="FunCoup" id="A0A401GCF1">
        <property type="interactions" value="931"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCF1"/>
    <dbReference type="GeneID" id="38776757"/>
    <dbReference type="InParanoid" id="A0A401GCF1"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="371" mass="39591" checksum="35E8ED77288BBBC5" modified="2019-05-08" version="1">MSKRGATPPPEGILVKRARSSSPQQAANQIAISSSNDERQQALIRTVKRTSGLEAPIISLAGSHGAEILSCRFDPSGQNIAACSADRSVSLWRTYSPNANYGLLSNMHKAPILDLQWSLFSPLLYTVSADHTLHVTDLTSGQRVRKLQAHRGIINSLDRTMAGGAGVELVVTGADDGTVRVWEGGDEGAKQPISVFEIGCPVTSVCWSADGANIYAGALDNEIHVLDLRKNEQVYSLAGHTDTPTSLSLSPNGNFLLSPSFSSQTIIHDVRPFSPSPARIHRVLMGAPAGFESTLLKGAWSRDDGGRRVAVGGADRTVCIWDVESGRVLYKLPGHKGTVTAVDFHPKEPIILTGSKDGTMLLGEIEPSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD83</accession>
    <name>A0A401GD83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0213470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611057.1">
        <property type="nucleotide sequence ID" value="XM_027755256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD83"/>
    <dbReference type="GeneID" id="38777061"/>
    <dbReference type="InParanoid" id="A0A401GD83"/>
    <dbReference type="OrthoDB" id="2788720at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18785">
        <property type="entry name" value="SF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="171" mass="18488" checksum="065C29A5239298B5" modified="2019-05-08" version="1">MHSINCPECKREGFAALYEREDEQRSAIFVATAVLEVGVNIPGLRRVISYGGSKSASSWIQEGGRPAREPNTHGEAIFYVKKSDIDAAITYVQSEPVDERLLTARDSNAHIGEDDRTASDVEAGAAERRSEGDAFCTDDLAMPGPSENGNDDGEGLCLDYLGWTFVLEASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEC3</accession>
    <name>A0A401GEC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0302410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611439.1">
        <property type="nucleotide sequence ID" value="XM_027755638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEC3"/>
    <dbReference type="GeneID" id="38777443"/>
    <dbReference type="InParanoid" id="A0A401GEC3"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="172" mass="19173" checksum="F06E18F0C08EE9D9" modified="2019-05-08" version="1">MVPVNRLNITQYPMPGPTVPPGGIYAGLFRRGDGTFHWTIIISQDAGHVVNKFHATEDSRGWRFEYSLHTIVRSVSACAVVKIGTLSSNRLVGDIHTLLKDIPMQTPVADLPQSFSCRIWFKEAVRVLSNNGIIRCPAVSRLEAELKGIAREQEVLIGLGYDYKIFVSDYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEC8</accession>
    <name>A0A401GEC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0302530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611451.1">
        <property type="nucleotide sequence ID" value="XM_027755650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEC8"/>
    <dbReference type="FunCoup" id="A0A401GEC8">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEC8"/>
    <dbReference type="GeneID" id="38777455"/>
    <dbReference type="InParanoid" id="A0A401GEC8"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE80538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="18011" checksum="5D764F9BA062C3D8" modified="2019-05-08" version="1">MPRSAETASFRFNHTMLRVKDAQVSLKFYTEVLGMELADKAEFETFTLYFLVYNEGDQVTNHETRFAREGVLELTHNHGTESDPNFKGYANGNSDPGRGFGHIAITVDDIQTACDRFEKLGVKFQKRLQDGRMRHIAFILDPDGYWIEIVPNHLPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEN3</accession>
    <name>A0A401GEN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0303530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611549.1">
        <property type="nucleotide sequence ID" value="XM_027755748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEN3"/>
    <dbReference type="GeneID" id="38777553"/>
    <dbReference type="InParanoid" id="A0A401GEN3"/>
    <dbReference type="OrthoDB" id="2745353at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="197" mass="21854" checksum="7ED0F875540A4C18" modified="2019-05-08" version="1">MQQYDMYAWKTTRKANTCSRCKVIMYPGPEGSDINHKRSFCSDGVRQKPKKLEMLVDGKIVKSVEDVPAWPQPSGIFSTGTHFNPHVFLATIRTMYEDLVVKRSTGGEHSMEYVAFAALLEKRTVVDVDPESEPGGRMVLFELFKSLVVAPSSADLIVERGGIKYMRLDCLHESVSKADADGGDRCNSSDSEPTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEU5</accession>
    <name>A0A401GEU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0304170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611611.1">
        <property type="nucleotide sequence ID" value="XM_027755810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEU5"/>
    <dbReference type="STRING" id="139825.A0A401GEU5"/>
    <dbReference type="GeneID" id="38777615"/>
    <dbReference type="InParanoid" id="A0A401GEU5"/>
    <dbReference type="OrthoDB" id="419631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="441"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="720" mass="80885" checksum="65EE87299611141C" modified="2019-05-08" version="1">MFPKGPRFPAVKVPQVPGPNAYNPQEPDFDAYKHGAFLEKTTRFMKENVPDVPGPGAYDADAAAKTTRSSSRAGKPVTDRSAALQHKLEELERIHAENKKSHHLDLEHLKLELSRAQKSAAEHAERADKLKKQNDALESRVQELKKTGTSDQADLRELRMKLRVAEHERAQLAAKQGSAGEARQVLQAAESRRKEEVRERERKLAEVEKGLNSERKKRELAEARLADMKSKGDEELQAARVVANSLEAQLRDTRAAAQQMKGALLDLQKRTGDEEEGLLQRLEQHRMLVAQVATEYGRLASTTVPLSVHSRIKEESAILQMRVLRLERKLANAEGQVIELVNLIRHTKEDKQFLSARLREVDAETAFYSQALKDITQEERLDEPSIYRDLDNSLFSMGHEVLQSQASVQQGLVADSSVWSEFYRLRSDTLLLHSSALVKGLGNAEIQLEQSAAELAQAEGKYTELRATLEAAQVAHAEAQRQLSETTASLQISQVAEASTKKQLEDTRAKAQADVSRVEQALRTQKDANHRLAETAQKCRAAEEALQTEVDQMASELAQAERYQEAYNSLLEEVDALVYRNALAEEEAQRISRFNAEILGHNNPNQRIMYVDRIRRELYETKQKLLMSTRDRDAVAVNNEDLRHELELYKSVAVPPEMKPRTTVTRVGRVPLAIQNVNVISGTRLSESAKSLSSTGSLKKLEPMPEVEYGQGDMTIDELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEW5</accession>
    <name>A0A401GEW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial distribution and morphology protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0304370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611631.1">
        <property type="nucleotide sequence ID" value="XM_027755830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEW5"/>
    <dbReference type="FunCoup" id="A0A401GEW5">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEW5"/>
    <dbReference type="GeneID" id="38777635"/>
    <dbReference type="InParanoid" id="A0A401GEW5"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="608" mass="68892" checksum="8C18A075C0624F49" modified="2019-05-08" version="1">MACRREEQKHSGLQNSGEKQSRTSSTTTERPEDQKPEEPPPVGLDNYPRLFRRLAASLPHLHRPTRDDFLRASTGFWQRARVRFKWLTIRSFRKYNADDISAFVTWFFMSQTLWLFVGTTTFFSVVFTTLNSLRLQEYVARALSDYITSETGITIIFESAIVPKWKDSRISFKNVYMTRRPNGGKHTERKKPDLNVGYSAALGYDVSNHPSNHHIFDEDEVNIEDISDEDTNYSMFDLSVESIDVTLSFARWFKGKGLVADAVVKGVRGVLDRRSVTWDPDHPLDPASFRLVGQPGDFELESLQLEDLLVTVYQPGGFRPYTASIFRADIRTFRKQWLFYDFLSAENAVGQFDNCLFSLHKPQSIGRTTEQDLMGGKWGRMSRFRIDGVNIDHLQSMTTQEGPFSWITSGKVDAVLDVKFPRDPQDELALNAILGELADAITTAAASVSDYIPGQRELAKPPLSAPSDNEDVAEDTPKVVIDIDLRFRDLKAAVPIFTSDLSYVNNALVRPIVAFMNANRTLVPIRSRVVTDLSNFDGSLTMWETGLMDMISLKVYEAMAYHVMQANFNRRVKAVSAWSLQMTASAILSALRTLMDPMAAHLRELINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF45</accession>
    <name>A0A401GF45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD linked oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0305270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611720.1">
        <property type="nucleotide sequence ID" value="XM_027755919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF45"/>
    <dbReference type="STRING" id="139825.A0A401GF45"/>
    <dbReference type="GeneID" id="38777724"/>
    <dbReference type="InParanoid" id="A0A401GF45"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD linked oxidase N-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="467" mass="49369" checksum="2143F507838F6063" modified="2019-05-08" version="1">MAPPSLSIPPSHFPQHIFNELSVAVRGPVCSRYSSEYVCSSMTKLLFMNMFHRFAERSRTFNGKLNSTSRIVVSPLDAEDVSTVVRFCTQHGLSLSVRAGGYGIAGWSVAGDVIVDLSMLKEVDIEAPKADAEGGKDWTRLADMPPPGSKGKGHVDAVPIKFSGVDIASTAAPLPSASQDTKAMQISTATAVKRRRGAHDDTPPDMDEERKRNRLGSYDAASQAVASFLRGPPLPYEAGEKPRDPPVDRGMLHGPASVEPGIPAEPEKEDEPHLPVLDANSRQVSTTLSSSTGSESGADHTSPSRSSIGTAATTPPSGSPDLPSTNTPTFRGAEPFGYITSGFTFTERPPVYSSAHPLGFVSGLSSGVSNVTAWRSSGQWGGVGVIPSVSTRGLGSIPSAFAFPSGATRHLGNLTPARPVHPHAYLTFGAGMLQKELDMYTADHPLEGISGVTGAQEDRLMPYHIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG35</accession>
    <name>A0A401GG35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0308100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611998.1">
        <property type="nucleotide sequence ID" value="XM_027756197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG35"/>
    <dbReference type="GeneID" id="38778002"/>
    <dbReference type="InParanoid" id="A0A401GG35"/>
    <dbReference type="OrthoDB" id="3197787at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="231" mass="26386" checksum="D1283F00884D9383" modified="2019-05-08" version="1">MLAVSAGLGHYFIDLFRPSQVRGAFSAQQWQSPNSSGPQDIWRRYFSSPVNTPKPREIGVNPSELVGKVLKHVQRSRNHPSVTLHFTDNTVYQILVDGYNPVHRGLPKDLEMDSGLEPILNPADGRCDVNLTLTNATVITMVDKAFQLGERESQWDQQHSALALRFAEDNQWHCVWATLMDWERDESGESRCVFRSYHDVYVNTFQPSVRKGAGVYKSFWRGIRKLNRKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGB3</accession>
    <name>A0A401GGB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0308870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612074.1">
        <property type="nucleotide sequence ID" value="XM_027756273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGB3"/>
    <dbReference type="GeneID" id="38778078"/>
    <dbReference type="InParanoid" id="A0A401GGB3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="165" mass="18977" checksum="99D9D9DDF06D5CAE" modified="2019-05-08" version="1">MSYYYPTTYSTYPTSFASPYRYSSAYNPYSLSTIPYSGLATTYPSSYAYAQPYAYAYPSYPQPYSYPQGYPQGYSQGYPQGYPQGYSYPQTYPLQQPYPYIPPSPNPPTTIYLQPSHTHRHHHEGHPHSDTESIHSHHSHLSHLSPFHHPSPYPYASYGQSGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGK7</accession>
    <name>A0A401GGK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0310470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612233.1">
        <property type="nucleotide sequence ID" value="XM_027756432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGK7"/>
    <dbReference type="STRING" id="139825.A0A401GGK7"/>
    <dbReference type="GeneID" id="38778237"/>
    <dbReference type="InParanoid" id="A0A401GGK7"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="512" mass="55368" checksum="58471154865039EE" modified="2019-05-08" version="1">MNFFDAYDISGPSTPTSGQQAEPSLNEEVSQVVGQLSRFWGGFRKQSQTVFEAARKDIGDAVSQAQKEINKLTTETLASTSTQEDHTGTEQTDQLPSAGESSAAPESNSAYSASASTIAEGDSRSTTPTETQPQPQTIFSRLQASLPPNLVSSVQSQLPDSLQHARAGSLSALDFAQLRSTLTTELHRVQDATGEYVQRSEELFREAGEFLKDAVKVLPPEESGGVSPGLIWDGSDVWMLPTEGSAGGRGELGSRKGKEREGRASSSSGRPSVEKLRAVATRAESLLKQLKHDPEVVKVDPQSDERVRHMFASWVESEVDAQEGGINSVQWKDTIENALTEPVDGAALKSTFDTLVPSVITSDMFWVRYFFRVHQVEREEERRKAIIQGTAQNEEDFSWDDDDDTTSTAVKAPLVQLHQDQTSDASDASALQAVDNKATLVAEAATPTQAPKSRVSTPGNQSPRESEDSYDVVSSQVSNYSGGIDSKAQSPSLPETPAPTAPVEDDPDSDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGL2</accession>
    <name>A0A401GGL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0309780</name>
        <name evidence="9" type="ORF">SCP_0309840</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612164.1">
        <property type="nucleotide sequence ID" value="XM_027756363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGL2"/>
    <dbReference type="STRING" id="139825.A0A401GGL2"/>
    <dbReference type="GeneID" id="38778168"/>
    <dbReference type="InParanoid" id="A0A401GGL2"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="510" mass="58030" checksum="2D5688E2BB04A3C6" modified="2019-05-08" version="1">MDPVDHLFHPGPAYPSYRQSFPQKTNISPHADPRPAHQPVYNFYPHRPSPPHSPAPVPLFHQQPPQDSHQRDPDQPVDQIHDDPPIDEEPLYVNAKQYYRILKRRVARARIEELHRLSKQRKPYLHESRHKHAMRRPRGPGGRFLTAEEIAAQKNLQADAGPSNSTSPDADDEDAIDVDRDIDRDVDMSVDSPIEPPKPPTFQIQQLEEQRVQPKLQALEEQDHSEKPRPPPASQPSIQPSIQPRPQRPRQPSPSYIQPQAQMQAQQQLQAQSQMQAQHQLQAHAQMRVQHPIQPQAPQMIRQHSQTRIQMQPQTQMQPPASAHSQTQQTIRRPSLTLQQQQQQLPQHSPLVHSQAQLQPQQQQQSQPMRSPTYEHPHQHQHMGMLHGTSPTNLMNVNANVGYHHPLSPAPVSPVPQDGHRAHEHSRHLGSHLQQVSSVQQMQDSPSQTTSPQMTSPQISLRAPYAAMQMHHVPHPHAHARHHHSLVGRGEQVYHDVPGSEYSGGASGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGN6</accession>
    <name>A0A401GGN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-hydroxyacid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0310080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612194.1">
        <property type="nucleotide sequence ID" value="XM_027756393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGN6"/>
    <dbReference type="FunCoup" id="A0A401GGN6">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGN6"/>
    <dbReference type="GeneID" id="38778198"/>
    <dbReference type="InParanoid" id="A0A401GGN6"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="8"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="122"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="38912" checksum="C92FACDDC68D8CC0" modified="2019-05-08" version="1">MARPRVLICGTLGWTQQECADLFEDVAEVIQYDSRNRTDFISSFQPGGRYEDVVALYKDGGSYFLGPFDRELIGAISRSVKYIANIGAGYDQIDTDACRDNGILLTNTPGVVDEGTATAALYLMISVVRQFAKAEQDIRAGRWNFEHSAGSAHDLTGRTLAILGMGGIGMRLAELARAFPMRIVYHNRRKVEDAPEWCEYFGIDRLDEMLAITDVLSVHVPLKDDTVGFVNEAMIRRLKKGAVIVNTARGKVIDEEAMIRALEDGHVSPTGFTDTTTKAYHSDHQLAGVGLDVFTNEPDVDTRLLELPNAALLPHMGCLTRETLEKMEIRALTNLRDMVVTGSAKDVVPELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGW6</accession>
    <name>A0A401GGW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carotenoid oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0311490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612333.1">
        <property type="nucleotide sequence ID" value="XM_027756532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGW6"/>
    <dbReference type="STRING" id="139825.A0A401GGW6"/>
    <dbReference type="GeneID" id="38778337"/>
    <dbReference type="InParanoid" id="A0A401GGW6"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61380" checksum="A51826963CF4E86A" modified="2019-05-08" version="1">MATLTSHPEPTLVAASTNIGHALVFENATEQREPITLHVRGRIPPWLTGSLYRTGPGTFRVASGSARGHSVNIRHWFDGLGLTHRFEIMPDGSVQYRNHSTAEGLQSRISRAGTIPTVTFGVQDPCETLFSKFFTLFKPNTEAPRRAGKCAPDEANISVTLTPNMPGIAAHHSASTTPSLRNLVAKSDQNALQILHPETLDPLRVMTYTQLDPRLDGQISAAHSCHDPTTGEFFNFTLKLGPSPTYKVFRIRPEDGKPPQTKGHTVDILAEIRDAPAAYLHSFAMTQKYVVLCVWQADFSCYGVSVGLNRNLAGSFKKWDPKRDTLFYVIDRNDGGVVAKFNAPPFFNFHKLNSYDSGADDIVIDLAVYDNHSVIDLLYLDNLRNLDENIYARLTRARRYVLKDVGQNKGHIRPAEIEFTLAHELNIELPTIHPALYYKPYRYAYGINKADPTVQSFADRIIKLDMFDLTAKPKLWGAPGYVPGEPIFIPRPGSNPRGGEDEGVVLSVVLDADAQKSMLVILNAKDLKEEARAEMQTHVPMGFHGAWVKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHJ4</accession>
    <name>A0A401GHJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable 26S proteasome regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0400310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Component of the lid subcomplex of the 19S RC.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612573.1">
        <property type="nucleotide sequence ID" value="XM_027756772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHJ4"/>
    <dbReference type="FunCoup" id="A0A401GHJ4">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHJ4"/>
    <dbReference type="GeneID" id="38778577"/>
    <dbReference type="InParanoid" id="A0A401GHJ4"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="189"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="385" mass="43486" checksum="4093989E5574A9D5" modified="2019-05-08" version="1">MPEDVVLPIPNSALPQYFFVLSRPSLSHLHENARKELLAGIQADQMAPYYRLVTAASILPLDQALLESMEKANKEELEKLDLRLSEAEKTEGESDIADALHARANHLTRIGEKDKAIEAQKVALEKTAGLGSRIDMVLTLARIAFFFGDFQMITEKLTDAEELIEKGGDWDRRNRLKVYRGLHLLSIRQFKRGGELLLDALSTFTATELVSYNDFVALTIIANVLALKRVDLKKKLMAAPEVTQVIGELPTLADLMKNLYDSHYDKFFFALSTVEQSHLLPSRLLSPHTRFYVREMRILAYSQILESYRSLTLDSLARSFGVSVEFVDNELSRFIASGHLHCTIDKVHGIVETNRPSLKNAQYETVIKQGDLLLNAVQRLSKVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIC9</accession>
    <name>A0A401GIC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0403220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612859.1">
        <property type="nucleotide sequence ID" value="XM_027757058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIC9"/>
    <dbReference type="FunCoup" id="A0A401GIC9">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIC9"/>
    <dbReference type="GeneID" id="38778863"/>
    <dbReference type="InParanoid" id="A0A401GIC9"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="332" mass="35427" checksum="3B81B8D79E6C031D" modified="2019-05-08" version="1">MEPVIQKILVVGGNGFLGSAVCRAALARGMRVTSISSSGRPYTTPKGHSPAWTSKIEWRTGDALQPESYAHLLPGVTAVVHTTGTLFADTRYKNALKDGNVPALLGTLVSNLTASGSSANPLEKRDAPGEYERLNRDAALRVCETFLASPPSVPVNGPRPFIFVSAEDATRPFISARYIETKREAELGIENMTKGRPDYRAVYIRPSMMYHPHFRPVTSPIAALLDLSATIHSKAPSGFPTPSSVLRSLASAFPAASSDPSPLVGPSPLDSIANALTIPPIHVDHVAEAICIAVDQARPDVKGVVGVKEMRDLIGWSSKGQQQSSVRAQPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ84</accession>
    <name>A0A401GJ84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0405610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613094.1">
        <property type="nucleotide sequence ID" value="XM_027757293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ84"/>
    <dbReference type="GeneID" id="38779098"/>
    <dbReference type="InParanoid" id="A0A401GJ84"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="54" mass="5761" checksum="10279D90F070E9CE" modified="2019-05-08" version="1">MRLGPYLQIEDFNVRAASPVSSITSSSGDVRGSDIPCLRGRPAFENQDPGVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ85</accession>
    <name>A0A401GJ85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0405850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613116.1">
        <property type="nucleotide sequence ID" value="XM_027757315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ85"/>
    <dbReference type="GeneID" id="38779120"/>
    <dbReference type="InParanoid" id="A0A401GJ85"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="121" mass="12802" checksum="85458D448C127B1C" modified="2019-05-08" version="1">MVEELVNRVVVETEVGLVDEVVVDCMTAVAMGADDDGLDAVAAGIAEVAVDVVGTGADTEAEADKLTDKGLLELVEPGLEMEEVGLFEELPDRDDILVLDNPEVGVGDCDDGTLGKWKWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJH3</accession>
    <name>A0A401GJH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0407000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613229.1">
        <property type="nucleotide sequence ID" value="XM_027757428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJH3"/>
    <dbReference type="GeneID" id="38779233"/>
    <dbReference type="InParanoid" id="A0A401GJH3"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="93" mass="10148" checksum="C6AD4C18132C9B11" modified="2019-05-08" version="1">MLVRTYLRASRAGTDIHRYVLLGPRSTFAAGAVVRTGYIRSAGFLSFLPLLYPVYWGVSEGGNVISPTGEMMWYGILDSISSKYTDTGYCPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJP0</accession>
    <name>A0A401GJP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0407530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613282.1">
        <property type="nucleotide sequence ID" value="XM_027757481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJP0"/>
    <dbReference type="FunCoup" id="A0A401GJP0">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJP0"/>
    <dbReference type="GeneID" id="38779286"/>
    <dbReference type="InParanoid" id="A0A401GJP0"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044715">
        <property type="entry name" value="WDR86-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489:SF11">
        <property type="entry name" value="WD REPEAT DOMAIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="80"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="416" mass="45655" checksum="7A417621F4832B64" modified="2019-05-08" version="1">MIPVATLSTNPPQFIRAEVELIREDLRRRKAVSTKNLGSPLEIPGKALALQVRGDNAWIAENDHLVRKLDLETGKSLQVFRGHTAPVTCLAFFDKVQGSGAGDILITGSWDKTIKLWDVRTKALISSTNAHTDFVKVLLVIPALRLLVSGGSDFVVRLWDLSAIQEGKPLPSVGSISSHTRPVEALDARAVTDSTAVLYTADTMGIINVWDLTREDDDDSGGGVPPRWRSTLQDSLDHHRTRINAMVYGSGQLWTASSDDTVQVRLYPPSPGSQPRIPPIAHPTAVKALLPLALTPLAEPYLITGAGDALRAYDVSELDEPELLGTVDGHWHDVTALQLWMRRIPAAVEGGRVRVEPWIVSASLDGTIRRWKLSELLHPPPPKPAEEKKMSATVRMSEEEERELADLMDLMDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJW5</accession>
    <name>A0A401GJW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0408390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613368.1">
        <property type="nucleotide sequence ID" value="XM_027757567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJW5"/>
    <dbReference type="FunCoup" id="A0A401GJW5">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJW5"/>
    <dbReference type="GeneID" id="38779372"/>
    <dbReference type="InParanoid" id="A0A401GJW5"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="11">
        <location>
            <begin position="45"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="218"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="392"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE82455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="544" mass="59017" checksum="718CC0FFDFD4DC1F" modified="2019-05-08" version="1">MTSTMLEPLAVPATPLTRPPTCILPFSSRTPSFVLSSANKSYRHQYANIYFVRLQTLRPFVEERARRRWKDVKGSPEFVPRMLDVVKGQLCFIIGTVYMDMPLKPNVLEDLARDHSIPAPPPREKFFSSDDVVTLEDESGRICLTGEKIRSSCLVTGVILGALGLEKNSGDFEVIDICYPGMASQPSAGLSWGNLQQAVNSESMVVDESPNEPGDEWIALVSGLEIGAPSPSDGQIEMLVEYLTGEAGGPQDQSEAAHISRLVIAGNSLAPVLSTNGSVNEETDRRARRYGYDAANFSPHPTLNLSAYLLDIARTMPVHILPGTSDPSGIILPQQPMPRAMLGGAASFSSFSCETNPTYIRLGSGDALNQAQNGDLTNVGSQGKLIASTSKLAAKPAPESQQARTLLVSSGQPLHDMFKYVSSPPWTRLGIVEATLQWRHIAPTAPDTLWCHPYFSADPFVIGETPDVYVVGCQPDFGTRLVEEGGKSRDGGGEDVDMDGAHEGRKRCRIILVPGFRETGILVLVNMRTFAVRTVQFAVTTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJX5</accession>
    <name>A0A401GJX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0408330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613362.1">
        <property type="nucleotide sequence ID" value="XM_027757561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJX5"/>
    <dbReference type="STRING" id="139825.A0A401GJX5"/>
    <dbReference type="GeneID" id="38779366"/>
    <dbReference type="InParanoid" id="A0A401GJX5"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="69"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="536" mass="58946" checksum="14BB8B58214A3276" modified="2019-05-08" version="1">MSRETKCHGGPEPDIVPACSDDEVRTALDGRKDVKYAGSGTHEDPYLVEWEAGDPENPYNWRNNRKWLITFQLAMSTWTVSFCSSSYTGGLALTMKDLHMSQEVAILGVSLYVLGFGMGPLIFAPLGETYGRRIVFLGTFGVFALLHLGGSLGHNTPTLLVTRTLAGTFGSSPLTNAGGAIGDIWTARERGFASSLYATAPFMGPVVGPIVSGWVSQTYLGWRFNFWIMFMLSVMSLIFGFLVTPETYGPVLLRWRARKLRRESEGLVVYSSVYDVGRSKSLGDILKVNMGRPFYFLATEPIVVLLAIYIAVAYSTLYAFFAAYPIVFQDQRHFSPGQGGLAFLGVGLGVSFGLCLAPVQNRLYWREMDRSPNGRAPPEARLYMAIIGAVCLPVGLFWFACRDPVPWIVPVLAGVPFGTGVALIMQGITQYLMDAYQMYCASAIASTVVLRSIGAALFPLVAPLMYRRLGDGWACSIFGFLAVACMPLPYLFIKYGRWVRSKSRWVYKDDVLRSGDVEIDAKLTSTVNVSTVKGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKY4</accession>
    <name>A0A401GKY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0412220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613748.1">
        <property type="nucleotide sequence ID" value="XM_027757947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKY4"/>
    <dbReference type="FunCoup" id="A0A401GKY4">
        <property type="interactions" value="721"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKY4"/>
    <dbReference type="GeneID" id="38779752"/>
    <dbReference type="InParanoid" id="A0A401GKY4"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="11">
        <location>
            <begin position="213"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE82835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="629" mass="68476" checksum="6AE5DC218CB336CC" modified="2019-05-08" version="1">MASQPSQQYAFRAQKSLGLVGGSPNYDSLNNFQSPDVPARTYQYSSDGRLFAYAIPSGVRIFQAESAQLLQELLLPNIVEINFSPRGTYLSIWERPVKLEDGSQHKNLRVFSASTGEELVSFTQKSQGGWDLQYTISESHAIRLVGQEIQVYRPAEWAKGIVDKLKVEGATTVTLSPGLNPSVAVFVAEKKGQPASVKIYSLASITGLPTSQKTFFKADRAQIKWNTLGTQVLVLTHQEVDQANKSYYGETGGLYLLSAAGNFDCRVTLDKEGPVHDFAWSPNSKEFGVIYGYMPAKAMLFDQRARSLHDFGTAFCNFISFNPQGRLFAMAGFGNLAGKVDIYDRRSLIKITSIDASNTSHCEWSPDGRFLLTATLSPRLRVDNGIRIWHCTGPLLHVQQVDELYQTSWRPTPVDVVPAFPQVMPLCPPPTASAQQHATVAKPTPLKAGAYRPPGARGLEASAAYTRDEGTPSGSSTPNGRFSRSPAPGRVQTNGRRHVPGAPTSPSPVRNGDVERRGRKKKSGKKEGLSSPASPGVEEPRPSIEVQIDGAVEEPSSPVNGSVPPTPSGDGSTLDPIAKKIRNLNKKLKAIEELKEKAEKGDRLEATQLKKIDSEAEIRRELTALGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLG9</accession>
    <name>A0A401GLG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0500450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613915.1">
        <property type="nucleotide sequence ID" value="XM_027758114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLG9"/>
    <dbReference type="STRING" id="139825.A0A401GLG9"/>
    <dbReference type="GeneID" id="38779919"/>
    <dbReference type="InParanoid" id="A0A401GLG9"/>
    <dbReference type="OrthoDB" id="3222238at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63649" checksum="C567CC9BD16B0A7D" modified="2019-05-08" version="1">MKRMTEVAAESESLVLACPPRPEGRWYILLQPSCLRISVSDHATLRTLTLRMQSEAHTALFNEDILREVAQHFRTSRREDVNALGRMALVCRAFSDPALDVLWRNLESLLPLLNILAISVDLADHAGDVKPPMRQASLTCISDAQWNRFRSYARRVRSVQIHRYMETLHSPVIAQLATRSCGEPLLPSLVSLQFDLISAKSVSEILAFLSPLLHDVTLQVGSWGLDTSFVTDIGRDFVFALRCAASSLRHLTLERFDDPDFMTHTDFTPFSELQTLDIGRCVASFSVLSACAKMSSLITLDIGLKGLTVEDIKRCHGFPVLENLSVHSHPSQATALLPMLSTTVLRSFTYIDQAYHDRFLRARQDLGNYRVMLAALHSKSAATIRGVYFTIAVFDDVSTPSLMSVIDPLLDFRVLEELRIDSSLAVSVTSDDVCRMAFSWPNIQTLDFSVYQGSVSPSVYSLTEFAQWCPYLIFLKLPGLDPRPALPPESEWVSTSSCSLKGLCVTGRNNVSLDAHYEHGHSIAVAHFLNHLFPNMTMEHCVGKEWTDINAVLEILQDAARRGYSGKQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLJ7</accession>
    <name>A0A401GLJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613976.1">
        <property type="nucleotide sequence ID" value="XM_027758175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLJ7"/>
    <dbReference type="STRING" id="139825.A0A401GLJ7"/>
    <dbReference type="GeneID" id="38779980"/>
    <dbReference type="InParanoid" id="A0A401GLJ7"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="357" mass="40520" checksum="19A6709E2CB126AE" modified="2019-05-08" version="1">MSLSKRCGRPPQHRAFQPGKRHMDLLPSISRSSGLDKDGDALTDFTVQEEYREYIQGKLEEYWRRRGAPDAEKGRQDVEQNLLILFRKLREGVLSSNRSDEFALKVYETSVHLSILFHSPGQTTSTLSHLLPELYLRVFPSPPPFADSGHPAFPTTILALLHNLISGYPSQSRYHELLHSLPRTFLPRDSDAYRWMDDLTRTLRRRNYARLERLTQRDAFASFAAPDKVTSSGHAGKDGSTADADNRAKSLHLEALCTLVDAVRAKARETAWRILRGAYRELTCPLPGRTAEVPLTTSEWLARSLTLRSVLPQRIDHSISIAQLVDDWLNGKCKEGEVRRKEGIEGRWIVCKVPVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLM5</accession>
    <name>A0A401GLM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0501080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613975.1">
        <property type="nucleotide sequence ID" value="XM_027758174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLM5"/>
    <dbReference type="SMR" id="A0A401GLM5"/>
    <dbReference type="STRING" id="139825.A0A401GLM5"/>
    <dbReference type="GeneID" id="38779979"/>
    <dbReference type="InParanoid" id="A0A401GLM5"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="208" mass="22753" checksum="09D46CCF7C445C17" modified="2019-05-08" version="1">MVKRTFLAEDERRPGCTHVLLMTTGSVASIKAPLIVSELLSYRAVKVEVVSTKPSLAFFDVGAVERAGARVWRDEDEWTEDGAFRIGDPILHIELRRWADIVIIAPCSANTLAKIASGICDNLATSLLRALAPTTSTYVFPAMNTLMYEHPLTSEHIRVVREVIGYNVVGPIGKTLACGDIGLGAMTEWKDVVQVVVDKFGLVRKNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMC5</accession>
    <name>A0A401GMC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0504250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614290.1">
        <property type="nucleotide sequence ID" value="XM_027758489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMC5"/>
    <dbReference type="GeneID" id="38780294"/>
    <dbReference type="InParanoid" id="A0A401GMC5"/>
    <dbReference type="OrthoDB" id="3060725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="372" mass="42076" checksum="06FC5EE13FBC5B71" modified="2019-05-08" version="1">MASVAGNQLPTCYKTRRQDGTYDRIMAQLSKSLDQMFASKDYPADFARTTNRKGHYEYYSTGDNPSEFSALIIGQVMVSEWGTDLYAKGNFRPYDDNKITDDTMVRNTLVLCVPSQVTTDLTEFYYDQIGTLNDIRMMDEKEEESAVQNFRVTEWIRSSSMEPGKPSDLIVVTIADPKYTMRANLPINAAATAAPKVKHIKKKRTANAEAEKMQDVQQELTKPTGDDIRIGANYDPHLLLNYGGNLFDHQKARLHQHDFRGIDGMLIPPWDWFTALRRGTLVLLNVSLHCWIYPPTNPKFPTRKTYQVQAHNLRVLSESDEFCVIPRPTLSPIVRVSAHSSNPLTAFTEFNASPPKKAKADVTKGKVKAKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMI1</accession>
    <name>A0A401GMI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0504860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614350.1">
        <property type="nucleotide sequence ID" value="XM_027758549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMI1"/>
    <dbReference type="GeneID" id="38780354"/>
    <dbReference type="InParanoid" id="A0A401GMI1"/>
    <dbReference type="OrthoDB" id="2804750at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="869" mass="91879" checksum="C7B3C9D47357F65F" modified="2019-05-08" version="1">MMPTGRSSTASARLRSKTSDLTDLLRGGRSELKQPAIHLTPSVPPPAEPTPPSKGKRRIDILFLGRKRKSSSVSPSSFRRSQDNRTDQEDDIPPVPSVDTSRPSNSNATGRRSSSTPSSPQTTSLTTVDEAPSSGTFAHLFTSRIPPRTGSSSHAANTHKSDSAKSSSSLPLPSLRHLRPQKSTSFEHGRRSTDNRRSNDSSRQSAASTHPTITISAPPSTAGDVTPRPAPAPPPAIVPRTARRNFGIPRDYRTSQSSPQSSPTSPRPKMQFTTPAAEYARLQMSPKEVSFPRISKEHAEVDRQSESESVKTSLASSKDRVHKHISALPLSAPRYREKSYTLAIRRGYMSDSTSGANMSDSDAAPSSPTTPTRSRIPATVSALRSATGKIPPPLLTTFRRPPSSGPPTDPLPSPPPSIRSGDEAGSSISALPTIPSFPSVGARRSATSLQQSYLRERANTNCSHTSLSAAKEKSDTTATAPSSSTDWSEAERDVNKPLPTPIVALQESGDESASALGDVATPEQLRDALNAQSAKFARLSAYLLTVTEKHAAEKSELTRRIEVLEREARKREREITGLRWLVMNAGQNAAGEPGGTTAKTAPRIDSAARFRSGSKSSQKSQASHRSSHGETRGPMSVDSHTGSMEEGLIELQNSVSDFIAPATSPPGTAMGASPSPNPSISAVTGRLRRSNTLPDGPAQLPDGLLKQKQTRRTSSPVMPASASVPATSVGTSASSIPGAGLGLDLPSIPSLPGSDSGQSSFSLPSLTATNTASSGLSAIPETPLTPGATAVDPAREREKRAKEERRASRALKRISASTTSSSMSTSTAYSSNLKLGASPSIGQVLDRATESDSDMEVILRRLQGFNGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN33</accession>
    <name>A0A401GN33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable alanine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0507060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614564.1">
        <property type="nucleotide sequence ID" value="XM_027758763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN33"/>
    <dbReference type="FunCoup" id="A0A401GN33">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GN33"/>
    <dbReference type="GeneID" id="38780568"/>
    <dbReference type="InParanoid" id="A0A401GN33"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000151">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="90"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="481" mass="52599" checksum="0C77963A3A73D29A" modified="2019-05-08" version="1">MRPLTPADLNPAILNVQYAVRGELAIKADEIREKLESSDDHGLPFSKVISSNIGNPQQKGLDQPPLTFPRQVAALMEYPPLMELVKDKWTPDVIARAQELHDASGSIGAYSHSKGVPLIRKHVTQFISERDGFPSDPEDIFLTTGASSGVSLILNTLITPPNTGILIPIPQYPLYTAVLAQFSGVPIPYHLSEPDGWSTTLHEIEGALVKAVKDGIKPKALVIINPGNPTGALLDRHTMEALVHICEDNNLVLLADEVYQANLHRPDEHPFHSFKQVVRRMGSPVPLFSFHSISKGVSGECGRRGGYFECCNISHEVRALLYKMVSVSLCPPLAGQVGVDCMVRPPKPGEPSYALWKKETDTIHAALRHRTQLMAGRLNKLPGVSCVNSPGALYLFPRLELPPTAIAAAEKVGKTADTLYALELLEETGICVVPGSGFGQKEGEHHYRVTCLCPGVEEYVGALENFHMKFLKKYNALPVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNA2</accession>
    <name>A0A401GNA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0507490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614606.1">
        <property type="nucleotide sequence ID" value="XM_027758805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNA2"/>
    <dbReference type="GeneID" id="38780610"/>
    <dbReference type="InParanoid" id="A0A401GNA2"/>
    <dbReference type="OrthoDB" id="10616283at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="338" mass="38563" checksum="79290E7DAF5D6B74" modified="2019-05-08" version="1">MQDIRLFNHTEPLQVTFSAYPDIMSPCIHDDPHVDSERAHNDTSPACLPIELQLDIIEQRILDGPDAAHQISQVCQLFRHIALPFFVRTLSPVEQARQLVSLPEHLLPYVQNVWMEDGRKSAYPLLSTSWIWESVPNLAIRTSSLYARMRLDPMRPILCTKLTLLPSDENHYRGLQIAISHCFLTQPFYLTNLTHLQWCATRHTPALPRLLLAAPCLTHVALPFRPSLPYATHIVLRSALVLVPKKQLMVVIVLELSLLMARGLGGLIAEVENCRKLDERLYLAPGAVECDHMRKEWEQLIDGGEDVWQRAARLRKAVLAGDVEQLRREYPFSQENTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNZ9</accession>
    <name>A0A401GNZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0510060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614860.1">
        <property type="nucleotide sequence ID" value="XM_027759059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNZ9"/>
    <dbReference type="FunCoup" id="A0A401GNZ9">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNZ9"/>
    <dbReference type="GeneID" id="38780864"/>
    <dbReference type="InParanoid" id="A0A401GNZ9"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.920.10:FF:000003">
        <property type="entry name" value="DNA primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE83947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="412" mass="47460" checksum="714857BDB01155C8" modified="2019-05-08" version="1">MAIANDIELPSPEIMLAFYRRLYPFKSIFGWLNHEHAPTRLFTHREFSFTLQGDVYLRYNSFTTAEDLKKQVCTLNPTRFEIGPVYSARPRDKKTVRPGAFTPVLRELVFDIDMTDYDGVRTCCSGADICKRCWMFIAAAMRVLDSAIRDQFGYKHLLWVYSGRRGIHLWISDREAMELTDEERRSLVNWLTVIQGGKDMSKKVNVRMGSRSLPPSLQSALGLLAPVFSDLILGDQDCFASEEGWQELLKLIPDGTIVEELRSAWEKKPRSSDDKWDDLSKKVKKSPKFNILMAAREDIILQYTYPRLDAEVSKHRNHLLKAPFCVHPKTGRVCVPVDPDSIYSFQPERVPTVGQLLRELDELAPNAAGDGAERHADWEKTSLKPYVDMLDRHVMALMEDVRWRKRGTDISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP01</accession>
    <name>A0A401GP01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614845.1">
        <property type="nucleotide sequence ID" value="XM_027759044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP01"/>
    <dbReference type="STRING" id="139825.A0A401GP01"/>
    <dbReference type="GeneID" id="38780849"/>
    <dbReference type="InParanoid" id="A0A401GP01"/>
    <dbReference type="OrthoDB" id="2722301at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="67"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="403" mass="46507" checksum="CFBEADDD2DB8DC79" modified="2019-05-08" version="1">MDNIKATLCVSVQDSLPTSVRSWRDIDTTADPQWAQPWEFLRPFFREAGYDLYRAGINGKLSTPNTTTPPALDSFGLYGDRSKLRTHFIPVSQVFPARDTMDRDVVIKLISKGKEGENERQILQMLNSEPLQCDPANSTVPVIEFLEYQEYCFAVMPYCDGCDERPFLHASECLDFAEQVLEGISFLHTHRIAHLDISTENILVNHHGLLTQTFILQGQHEPPLKIWPPQEWRSTFPVRYLFMDFGYSIRFNEDVRLGKCTALPFPQGREHRAPEVRGTQAFNPFAADVYQTARIFYGWFPDLVDDVPDLLKLLQDMSSYNPSRRITATEALARLRTLRSTIPDEKLKDLRERELLIFPLVPRSHLVMFRDILETGKWSLACQFAWALLQIWLFKTTGNEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPJ8</accession>
    <name>A0A401GPJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0601000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615035.1">
        <property type="nucleotide sequence ID" value="XM_027759234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPJ8"/>
    <dbReference type="FunCoup" id="A0A401GPJ8">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GPJ8"/>
    <dbReference type="GeneID" id="38781039"/>
    <dbReference type="InParanoid" id="A0A401GPJ8"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="13"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE84122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="472" mass="53187" checksum="9CC189A0272B5464" modified="2019-05-08" version="1">MSQKLKYPKISGYQLVQRIGGGGFSTVFRAVHFEDHRVAACKMIALTADTTANERRLLDKEMNVHRELKHKNVLEFISSVTIEPKKKSPYLPGLYMLLELAAGGDLFDKIAPDIGVGDDVAHYYFNQLISGLHYIHTEGVCHRDLKPENLLLDAAGTLKISDFGLSSVYKLKATGETRLLNERCGSLPYVAPELKINKPYAAEPIDIWGCGVILFTFLAGNTPWDEPTKKSEEYCRYLSGQCFNDDPWNRMGENALSLLTGMLAILPSQRMTLGEVFQHPWVTRPSQIAGKGMAVLAQRLTEALRETGDLEIATPDMNQFEVDEDGDTIMKSASLHKSQFTQSLLLFSQTQSGRRYTPHLTRFYSSLRRHDLQPLVTAALTVLGVKWKPPMEETDDDGDGAGVPMLSVRIGGFDKRKLMFKGWVLLEDFNYGEREGTFCVMQRDQGNPISWRLLWKSLIMSPQVEPHVLRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPL5</accession>
    <name>A0A401GPL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0601410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615076.1">
        <property type="nucleotide sequence ID" value="XM_027759275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPL5"/>
    <dbReference type="GeneID" id="38781080"/>
    <dbReference type="InParanoid" id="A0A401GPL5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="87" mass="9727" checksum="46152A74DDFA93B9" modified="2019-05-08" version="1">MNASSICTEIIGQRDPLARCRHYISKTNISTMSFLVFTEMHISQKMRTAEDLGLAGVCIRRILPPRSVGESFPALTLFPTVDHNCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPN0</accession>
    <name>A0A401GPN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myosin regulatory light chain cdc4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0601550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615090.1">
        <property type="nucleotide sequence ID" value="XM_027759289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPN0"/>
    <dbReference type="FunCoup" id="A0A401GPN0">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GPN0"/>
    <dbReference type="GeneID" id="38781094"/>
    <dbReference type="InParanoid" id="A0A401GPN0"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15458" checksum="47546A955440FA6D" modified="2019-05-08" version="1">MSDNAEYKEAFALFDKKGTGAVQREVLGDLLRALGQNPTQAEVAEIIASAPRDVDYKAFLTILNRPDGFKPAGTPDEFVRGFHVFDKEGNGYIGAGELRYVLTQLGEKMTDEEVDELLKGVPIGADGNVNYESFVRTILSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQV8</accession>
    <name>A0A401GQV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0605970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615531.1">
        <property type="nucleotide sequence ID" value="XM_027759730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQV8"/>
    <dbReference type="GeneID" id="38781535"/>
    <dbReference type="InParanoid" id="A0A401GQV8"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="310"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="817" mass="92632" checksum="1F93B5FEE895D25F" modified="2019-05-08" version="1">MVATPLAKNDPDYEVWQKPEDFDHSDVKGRYRRFASSARRFILGPMPLDEFLEFLPETDMSNMPRPINAFNEVPAEARTEQQIYKPLIAAINGTRSRKSQRRCPGFTFKDTATSGAELGEIGSMNAHVCCYSQDLNDSHSDPLGGADLYIDVQRYPSLDPFTDPTPENDRRSHEFVINVGDDRTRKHAEEALGRNVACATEVCARQHRAFYFSISLAGSRARLIRWDRCGAIVSESFDIRAQPGPLCEFLWRYAHASKSQRGYDVSVEPATREEEELFRESIKRHVKLQLDLDEEDLVAAMEEHYQPGVVVAVNMVDEGSPGQVARRLLISRPVVSPVSLTGRGTRGYWAVTADGPRSEVVFLKDTWRYNGQQQKEGAILADLQGAGVSNIPRLISHGDVLERLPIANRMDEDAEDGDVEELSLQRTLTDRFQQAHWVCKLEQIPQPPLVHYRLVLGTVGYGLQRFEGTQELLQGTFDAYQAILGAFNLEDVTKRRLHRDVSIGNIILFRDPKGTNTKRYGYLIDWGLSCLVTEEGEACDHTKAGTLQFMSQRILSHKKVAHTIQDDMESILWVVLYCSLRWLDHNLPLGDLAKTMVNIFDRCTVHDDGYVMASDAKLRIQFDRGYTSDIYFRNPTIQLWLDEVMKFNSSNMFPHVWGAAFAEVWKDPAMFNAFWRDFLRVHEISDHDRVWRELIRPDDHPYKPPSSSSSTSQVTHPAPAALPSRKRKAVEEPVGADAEKMTSSRVPAVPREGYRGPITRSMAKRRQIEGQGQGAVAGGSDLPIQDLWSPRRLRPRPKKIDKTSLARQGPKVRRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRA0</accession>
    <name>A0A401GRA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615671.1">
        <property type="nucleotide sequence ID" value="XM_027759870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRA0"/>
    <dbReference type="STRING" id="139825.A0A401GRA0"/>
    <dbReference type="GeneID" id="38781675"/>
    <dbReference type="InParanoid" id="A0A401GRA0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="348" mass="39624" checksum="7D580F1D062DF139" modified="2019-05-08" version="1">MSRLKTEHNASEDSSKKTESMLERTTLHLDGLKSTRAELEKKHGEAEQTVVELRRQLENKLESRESAEIDALRCECMELVVQVETLQTQVKELEERAEELESAAETATEKRKQKDEEYRGALDEWKIALEKAQGKEEKLEAEAKGLRSQLEDTQKNIKALKAHLSTTKTEARQATMKQSKRILPVRELSSTSEKEVDEVEEVVVAPSPSPQPKRNGRSKPRKAQKADSTSLKLARNLDVDSDEEVEPPKKTKRQPKPQSKNGNGDSRTGKSKAERKPRKDRDEEEVEVEVEVEVEIIEDKRIAGRKGKRKAEVLEEGDVEEPKPTWKRINKRSGDEDEDEDSGTRNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRP2</accession>
    <name>A0A401GRP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0700820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615815.1">
        <property type="nucleotide sequence ID" value="XM_027760014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRP2"/>
    <dbReference type="STRING" id="139825.A0A401GRP2"/>
    <dbReference type="GeneID" id="38781819"/>
    <dbReference type="InParanoid" id="A0A401GRP2"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000224">
        <property type="entry name" value="serine/threonine-protein kinase mph1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="473"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="834" mass="91790" checksum="EF35E44F2C603A43" modified="2019-05-08" version="1">MLASLSPSSSSLSPASSLPLSSLASPPLTPSQPSNDSRRTSPSGSDDSALFELSFVYEENSQGEYVRFSKRESSPPTPLDRSPVVLKPPSPVAPPRPSPLSRSESMPSVEPTPAPRSFQRVASGPVLTPASSSARASFAPLSTGAARKLGGARRVKVDEFQQSDPLLRSQTQPGDEKENLRTRASAAATAAPFAVRPLRTLPKKSGIEKIVEERSVEEADDPLDGPSRVSNRPRRSASLSDASGAGYHDEQPPYSYQRPGTSMGARRVTIEEKMRKEREIALIEGYAMREAEEAAEVERRVRQSPSPTHVSSQSRHQRRDSDTLRSLANPLPSPTAVEHLVPRTSPPIRGAYPPVRHRRSPTAPEPPTTSEAITPGPIAVVGRTWAAGDGREREREREHEEAYGDAVARARSLPAMSVPAPAPAPAPAASPLSTTSVTAKPQAKSHAHPPTAQVVTPAPDVRSRNMVVNKKAYARLDLIGKGGSSRVYRVMNGTNEIYAIKRVALDKTDAETMSGYMNEIALLKRLEGNSRIIRLMDSELRPGPGGSKGHLLLVMECGEIDLARLLQEQQKERLDLVWISYYWKQMLQAVHVIHEEKIVHSDLKPANFVLVRGQLKLIDFGIANAIANDTTNIQRDHQIGTVNYMSPEAIELPDGMRRLKVGRPSDVWSLGCILYQMVYGHPPFQHLSVYQKMKAIPDESRPIQFPEYATPSVPGRDASPRRLDHLSVRVPDNVIETMRSCLVRNPKQRATIPELLDQDWLVMRTQHPPTPPPLPTPPALKEDETIINPHFMKQLLQYGMLLGKQDRKMDDEALLRDADRLIRELQSVNQQGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRP3</accession>
    <name>A0A401GRP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84394.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE84394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65906" checksum="D5BE35292AE74BE8" modified="2019-05-08" version="1">MDGNQSLKLVDDLFRSGVTRSDGRMDRTDIWLTPEAVDQFKDEVARLNQQPQPSTSSGSAPGLPDDAHAELDDIDDDVAAEHGNTEGVLKPITVCVERWRNAGPKVHKKCLHCSHGELMKQPLAIIDKLIEVYGTNVKVGYDIACAFLKTLARSSLGPHATKARMSGVVPAFHGHGHNWGCQVHWHPLYMDDVGKEDFEGCERCFSESNALAPGTRLATSFHRHQAIEQFFGFWDEQKHIESGNFIYNNYKQALDIIMQDSEVLDVLSEELNIGPAEYERYLEEEREYLSGLKVEPPEVARKVDYMEALKHLEEAGQKCEQACVEFNNLDYNIIYKGYQKKEIAKVQMLYRTTYSWYEGVAEEVRLIEEELSIIERWLPGTQEYIEMTAELGRHKYRRALDNLERLVVQRLFELMKLGMSGVGYKLCEKIGKALKTRAEAIKKALAEYNRCALELSPARPTLTWSEVMDMVSLADFDLLRDARQDIHTLPWAQIHEKIAHHLYQTSQLAGFSEKVVCSRHIGRETGPTLGIPLPSWACYSNGDVYLAEDEEEDDGSHGIPGLSSELEAIHLVDFFDDLGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSH0</accession>
    <name>A0A401GSH0_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">SCP_0606630</name>
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    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027759796.1"/>
    </dbReference>
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    <dbReference type="InParanoid" id="A0A401GSH0"/>
    <dbReference type="OrthoDB" id="2811214at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="12544" checksum="E6E8EE67891F7F4B" modified="2019-05-08" version="1">MYLVGGYKLTPDQVLEWCGRHGLVPPEGCYAITVNRYLKSQMSGHRLLPCDYEGEPIFLVVTNRVIDPTATRTNYQPFEESDDARRIRKVLASDDLHVEFVTVPDPYADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSH4</accession>
    <name>A0A401GSH4_9APHY</name>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GBE85120.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="38782037"/>
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    <dbReference type="OrthoDB" id="3358078at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
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            <begin position="822"/>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
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        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
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            <end position="224"/>
        </location>
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            <end position="307"/>
        </location>
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        </location>
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            <begin position="1103"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1132" mass="121435" checksum="51D9BFFD3ACFE912" modified="2019-05-08" version="1">MTSRPLPSKSRHSRPLSAIFIGSVSSNSTPPSIPDLPEPPSPSSSTGSGLPSPPATNSTGSGSIGYQHSYSAGSLRQRSASRSSVAADMVKGDYDRSRSSGNRNRTASADDDDAFENENEEDNTARFANGRRLQHASVDNMSTLQRVKNLTQRNRLVLDKLTSISRLSSPAPTNSSHPPISPPNASSSSTSSSRLSSSHVRPVSMNGYAALRRFDSGSETERESQSISNYYSSSDDLSATPPSVPQEIHTPVPGRERRPSAPAIPGSLVRPSRDGDRAPSPGPSRAPRKRVSMAMSVDETRSNRWRDDEQDVTTAALAAVASSRRSPQGTNGSSRRNRQPLPREFREGERPSSEVKANGEPSTPHRPTERYSSPAFSPHASTSMIPTNPQTSPRRSGTARYSTVRELTRKHQTRWLSEDLSNGNGDENSPTPGSGGVPGRRQGHRGGSSDGLLVSTSGRSLLGEGLRAAGLTKRRDAGDDVFTDESPTTPVVPRLTKSTGNASVNNGDWGDASLGQSKGVGLSTRVSEGVGPPGSNNFESRTPVTTSQRRGDRNSYSGVPIRPGTSMAALHHESPDNPPRTAPPALRTYKSVRPLPDRDSPASRQARQEPVQTSSDLAYSSPLASYASHRSSTAPPPSSKGQDANAEHRRLMLEALGMFESHLSRLPPMGQTTTNTIPGLFQSAQHLVHTLDKMNGMLRAGTHKALEAQIDAEVADSAEEVDPVNLWRQVGADHRENLRVSDEVVRNMTGFLLGVGKVLRDASALHGQHLRSVSLDDDAAKRGSPDVNGDRVASGSRPLDGRQSREIRRSWDAKDLRTLTMSSVERSVGSTRPASSLNILRRPGTSSSDGRSADATHEQTPPAMRNNSTAIPASSSTRRFFTTRERRGTPEQDSALAPIITSLDSQDTTNSYEPSPTPTSRHSRSALSERPRTAIPPSLSTLPSESLLSCASTVDTDKLSRRKISSNSNITVRAESSTINSVIKPPNPTTALTNATVSNSPDTRYPVLRSESSGSGRTNGVTFSRPSTISVSTLNGLQQQLDRDTRARTSSTISAAEEPIYLAPAAVISRSETERDKKRRTLGARSRISLDSAFGEEGGSVDSSASSILSSSLSSSARRERRRTINEIFSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT63</accession>
    <name>A0A401GT63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85360.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="XP_027616273.1">
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    <dbReference type="AlphaFoldDB" id="A0A401GT63"/>
    <dbReference type="GeneID" id="38782277"/>
    <dbReference type="InParanoid" id="A0A401GT63"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    </feature>
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        <location>
            <begin position="484"/>
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        <location>
            <begin position="707"/>
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        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
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            <begin position="429"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="457"/>
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        </location>
    </feature>
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            <begin position="491"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
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        </location>
    </feature>
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        <location>
            <begin position="917"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="981" mass="107940" checksum="816AD4A01918C39F" modified="2019-05-08" version="1">MADAKGRKTLVQSLRQKLKTQFVDTSNYDDIIVETKIREWLNNHACHAQEKVTKKRMHVSGKPNAFKVWDTLERDKVTEAARALAADKGCNVSKVWRVAWSAKWAKLSEEEQKVYEEKAKSWRNGTLDDKMKMKLREQRMMQYLKKFAKTMWDTMGIRMAFMLAYPKEAGSLKVEMVEVNHAITNGTPFGAYPGWLRAYQPLAKVFSEWAKGEYDVTETTVTVKKTPADCMRAMDKIRLMANGFPLLPSVPEGMAEAPLKVMKVQVRDFMNHHYALAKGVRNCKSPWTKLNSIDDINEVIPAEMLPENFQWIDPSKMTSVPVCALLDHWWARQEEHGPEQTMRFTQYFDKDGEAAPAKYDPLPPLDGSAQALEEGSEHEVQEALTPKKAGKAKKKGKPVRKVTGKVASKATKGKAAPGGAKGGGRKCKTKDAYDSEDDARSSQDSDRSSPDIPSMASEEDMASDEDSGDGESVIANKVKGKAVATTNGRKANNGGAPQASGSSGAKTKAKRGLQDLPLGELHRFDTEETDEASSELEPSTKELRLELQGRAPRLTGGSTVGSTVPHLVKRRDVFLATLSVEPRYQDMLKEVKIATVPQVYRFARYDPIPWSEWSYGQRYLPPSFHVVDNFDIVENWLGDKPWLTKYRFLHPQGFIEEGKPTNLSDYVVNSAISFDAVEQLLCCCEIITLDMVEGNVTHAMVKPVSKPAIRGAPQGGDGLGGQEEQEGDASARTHDGAATAAKVHKAHQPAPMADKPIIPSGGDEGPSQETSGGASDDGEEDDAHLSIPSSGAERPPPPSFIPKMRKAAATKDSLSGQAKVLQGRLITDALQSNIPGRITRSQRQAMDESPAKNTRSQHPLGAVKDLKKLPDPKRKRQPARPEPDGEDSSGEDNPPPRKRGRGTRDELVVASPRKKNARAEDSDDGDKPPTKRRRALPQTPEVKDKGETKLKPVRLGKAAAKVKESGQVGAGRKTRSGGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTE0</accession>
    <name>A0A401GTE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0706300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616356.1">
        <property type="nucleotide sequence ID" value="XM_027760555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTE0"/>
    <dbReference type="FunCoup" id="A0A401GTE0">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTE0"/>
    <dbReference type="GeneID" id="38782360"/>
    <dbReference type="InParanoid" id="A0A401GTE0"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="10"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="140" mass="15616" checksum="DE8C569AAA4E5C05" modified="2019-05-08" version="1">MAVKSVANCIFCKIIKGDIPSFKLIETETTFSFLDVGPLSKGHALVVPKYHAAKMHELPDEYLADTLFTAKKIAAAIGAENYNILQNNGRIAHQEVDHVHFHIIPKPSVSDDDGLVIGWPSKKADMEELKKLHEELRNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTG2</accession>
    <name>A0A401GTG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0800290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616425.1">
        <property type="nucleotide sequence ID" value="XM_027760624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTG2"/>
    <dbReference type="GeneID" id="38782429"/>
    <dbReference type="InParanoid" id="A0A401GTG2"/>
    <dbReference type="OrthoDB" id="19861at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="156" mass="17586" checksum="24D7C43E7D1B5D3C" modified="2019-05-08" version="1">MAWLKLLTLSQFPKDNTLAHHLWSTAWGQETFAPFDVDVVRDGTLLVDLDEPIPATCQVTNNHPFISKHLKHVVVRNEYVTTLDTLMALSVEVPNSSIIVVGHPGIGKTIFLFYVLIYRLQRGLSTFYQKTAESVLYFHKSGVYSIPANQEPDSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTZ7</accession>
    <name>A0A401GTZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0703900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616117.1">
        <property type="nucleotide sequence ID" value="XM_027760316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTZ7"/>
    <dbReference type="FunCoup" id="A0A401GTZ7">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTZ7"/>
    <dbReference type="GeneID" id="38782121"/>
    <dbReference type="InParanoid" id="A0A401GTZ7"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="40"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="238"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="438"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE85204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="601" mass="66184" checksum="4FE6BBCA5F5FBB29" modified="2019-05-08" version="1">MSTTQAVASLQAEVTRLRHELQTLKVEDQVPAIGDQIYIGQYLVERLVQLGVTQMFGVPGDFNLGFLDFVEDHPKMQWVGNCNELNAAYAADGYARVKEGSLGVVTTTFGVGELSATNGIAGAFSEHVPVLHLVGSPSTVQQKEKPMLHHTLGDGRYDAYFQASKQFTWTQASLTSKDTAAAEIDRVLTECVVMARPVYLMLPTDLAYEKISSKRLQTPINSEPPANDPDVENFVLDEIVKLANHAQHETIILVDACAIRHTVKKEVEELYRRTGFPVYAAPMGKTAVNEQYERYGGIYVGSLSSPEIKEKVESAKLILSIGGLKSDFNTGNFTYSIPTGRTVEFHSDHIKVQFAGFPGIGMKRLLPKLTARLQPFADEAKLLSVPKYTLPIPQEDGDVITQSYLWPRVGKFFKNHDIIVAETGTSSFGVLDIPMPTGAMFLSQILWGSIGWTVGSTLGAALAGRDIGMGRTILFVGDGSLQLTVQELSTMVRSGVTPIIFVLNNEGYTIERYLHGMNRKYNDIVNWKWTSLLTVLGGTEGKTCQSYTVRTKKEISALLDDPKFAAADKIQLVEIIMQRLDAPRALKHQAELSGLTNRYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU58</accession>
    <name>A0A401GU58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0802790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616670.1">
        <property type="nucleotide sequence ID" value="XM_027760869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU58"/>
    <dbReference type="GeneID" id="38782674"/>
    <dbReference type="InParanoid" id="A0A401GU58"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="17335" checksum="7DD86F5B2D8908E3" modified="2019-05-08" version="1">MQGPSISQAHGFSLLSIMNAGSAIGRVFPGLAADIAGRYNLLLLLSSSSLFTLELWLTQMHFQDLIAYAMIYGFFSGSINSLNVPCIAQISRIEKIGTRIGMAYSIMSFPALVGSPIAGALLTCAHGDYNTMIIWTGVTLLVGSALLLVEELVLNRNPLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU61</accession>
    <name>A0A401GU61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616636.1">
        <property type="nucleotide sequence ID" value="XM_027760835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU61"/>
    <dbReference type="GeneID" id="38782640"/>
    <dbReference type="InParanoid" id="A0A401GU61"/>
    <dbReference type="OrthoDB" id="2803839at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="282" mass="32132" checksum="224C00E73F51C6E9" modified="2019-05-08" version="1">MPLDREALRLAMQQRTPPTPRTPSTGPSTEAPADEAHSGHKRPHDDIDDSITDEENVLPSSAIALGSSSVLRPSVSANVATNLEVFTANECKKARLDETETAEVQAFNKLTFDKRLTRLYIKLTATDKRLGNFDEAKKQIQEKISPRRSCQSNIKTYAHAILLDPCLHGYHEKVPIKHLLTIIKRMRFDLPVDIKKNCAHWQLIKSEVGEVFTQRRRAFKEEIKKSTDWDIYTIMKRLIGDSGCKMSLELIARVAIMRCVFFEEEKTDNAFWIEVDKVLAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUM1</accession>
    <name>A0A401GUM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616809.1">
        <property type="nucleotide sequence ID" value="XM_027761008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUM1"/>
    <dbReference type="STRING" id="139825.A0A401GUM1"/>
    <dbReference type="GeneID" id="38782813"/>
    <dbReference type="InParanoid" id="A0A401GUM1"/>
    <dbReference type="OrthoDB" id="2804415at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="1">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="178" mass="17293" checksum="3CA960574CA8F3DC" modified="2019-05-08" version="1">MKGPDDPPPAIAAGLGTTHAANGPAAVATAVAAATAAPVAATVAAAGPLVITAAPTAAIVPAVAAPATAMAGPTAGPAGAPAPRLGQPNVPGPLNDPEALQAAIEGALVIANQPLPVLPGRWYVVTRGQEVGVFQGWASVSPLVSTVPNTCHECISSRENGFQIFRAAIAARTVALCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVG0</accession>
    <name>A0A401GVG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617130.1">
        <property type="nucleotide sequence ID" value="XM_027761329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVG0"/>
    <dbReference type="GeneID" id="38783134"/>
    <dbReference type="InParanoid" id="A0A401GVG0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10563" checksum="460F2A170B5D3BA5" modified="2019-05-08" version="1">MADPQNSQDFESEDAEPAVISLSDVISPSHTQAVFGADQATHKGDSSTTLNPTFERVLSARNAHVWVPIIASTRRGGKASRGCLTDLERDQAQLSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW98</accession>
    <name>A0A401GW98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0903740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617408.1">
        <property type="nucleotide sequence ID" value="XM_027761607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW98"/>
    <dbReference type="FunCoup" id="A0A401GW98">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW98"/>
    <dbReference type="GeneID" id="38783412"/>
    <dbReference type="InParanoid" id="A0A401GW98"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="115" mass="12096" checksum="D8F42BAA5F0FDD6E" modified="2019-05-08" version="1">MAPTKKSKAAKSTESIASRLALVVKSGKYSLGYKSALKQMRNGKAKLVLIAGNCPPLRKSELEYYAMLSKTNVHHFAGTNVALGTAAGKLFRVGVMTVSDPGDSDLLTVAEGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWC2</accession>
    <name>A0A401GWC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616977.1">
        <property type="nucleotide sequence ID" value="XM_027761176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWC2"/>
    <dbReference type="GeneID" id="38782981"/>
    <dbReference type="InParanoid" id="A0A401GWC2"/>
    <dbReference type="OrthoDB" id="2754773at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="833" mass="94174" checksum="6AFB64FBC725FD37" modified="2019-05-08" version="1">MILGSPRSYPFLKAKDEDEAEDGDFAGEYDSAGYSNTHWTDATKAAVPTLRELFQSSPIRAFEATPTSALYKSLVRVSPDLRPMLLDVVRRQAQNDEDKVKVSFSWDVIAEIFCLTQQNDDVLRLAENTLHYHSYHPEEMIASISLFSQIKSGWCEINEAFPEWQNTWVWLWDAKNEGLITVKLVPNATPYEQYQHQKSLDRFARKIRGGYLARDYTEDLEGVNEGDSDYEVEKARRRPNIRGEGGAFSPFWYKTGTHQHSSPHHFPELSIQPKHPSVQRDIFAMDRGHSSDIVPSPATATDHVLVSTSSEKPWPPVKRLPDELLMIIFAMVWDVMLKKGDITSWVGLTVVCRHWRAVTLATPVLWSAILCRAWSPTHWHKFVERSRNKPLRISIGMPLDEAFILDMIPELSRRLAFLGMGTESRAEELLPDLIFCMPRLRLLRVHCSKNVEYFWDLPQQPDQILFPSLYSLDLGGVALPWTSRILRSLVTLGLANLYQNAPTTEELLAILAACPVLSMLSLCDCGPSPPTTPFSQSLAKVTLEKLVRLRMEAEPLEIFHLISRLCISESCDLKIKTNVVNHGGFGEALRAAFPSDRSSLPVFKMCHKVSVGIVVDSTNHCHIHLVGYGLHAEPRFSFVISMQTDLTSGKGALDSLFEALPEFFPSCRSLSLVADFALFLGIAVDPPWDTLLASLYDLEQLRIGYVADTSELLHALSRVANSSDYTVPMCPHLNILMISCKEGCIDFSRLVNVLEKRASCGKRLQSLTIPRLVANGYVEGIRRLVEKVIEVQPDNGSGDKWRRVFCDEPEDGPWGDKWQREFCPSYQREYGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWS0</accession>
    <name>A0A401GWS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein YTP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0905560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617589.1">
        <property type="nucleotide sequence ID" value="XM_027761788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWS0"/>
    <dbReference type="STRING" id="139825.A0A401GWS0"/>
    <dbReference type="GeneID" id="38783593"/>
    <dbReference type="InParanoid" id="A0A401GWS0"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019575304" evidence="3">
        <location>
            <begin position="24"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="34"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="152"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="469" mass="51573" checksum="5C0AEE9CD35CC2BF" modified="2019-05-08" version="1">MRRPVALVRLAFFLLVLVGPAVAHEHHGELSEEQAHAPVDAILWIHIFLQAAIWGVLFPVGMVLGMTRSRWHVPLQSAGFALTAAGYVLGHSHGGRAFLAGAHGIMANILFVPIVLQLFLGIYLKLHIHEETIRPWAVRLHGIVGKSYPVLGWTQMLFGAIAFRGYCRGDNLGQCLAHYLMGTGFIAYGTIMSILLLVGEAWVRRSGRSPEWWDSWVITLWGIVNTFTEHHGPVFAAWSVKDMQHTILGVLWWAGGALGIFLSRNNQRSVVPSGIIFLTGWAMSEHAQALMLSTQVHAVFGYTLMLAAVTRLIEVCFIVPKFYPIPSVEVSDGDSHSEHTLADNGREDGNVGSGKVATVKAFRHLPPFLLVSAGLIFMSATDEELDFVHDEGMDHVTYILIMFSVSFILYTLIISLINLFASSGRNGFSAIVVDNGIELAPTPTTKWYSRVPAAELDGPPHIIGDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXB4</accession>
    <name>A0A401GXB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617789.1">
        <property type="nucleotide sequence ID" value="XM_027761988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXB4"/>
    <dbReference type="GeneID" id="38783793"/>
    <dbReference type="InParanoid" id="A0A401GXB4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="53" mass="5811" checksum="2EAB2E8D73260A18" modified="2019-05-08" version="1">MMGIQRTELAFPTLGKRSQTHPHHHPPVQSHIHPRSTPTSSSSLPLPLGLSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXD2</accession>
    <name>A0A401GXD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Benzoate 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1000820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617753.1">
        <property type="nucleotide sequence ID" value="XM_027761952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXD2"/>
    <dbReference type="STRING" id="139825.A0A401GXD2"/>
    <dbReference type="GeneID" id="38783757"/>
    <dbReference type="InParanoid" id="A0A401GXD2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="559" mass="62151" checksum="A08FB79A2CECF714" modified="2019-05-08" version="1">MTILEVLQNPRANPIPFVLCLLPVVVLAVHVVPYLVDEHGLRQYPGPFLAKFTDFWLFWVASKSRRTDAINELHQKYGPFVRIAPNHVSVVSPGAISAVYGHSTGTMKSAFYDAFLSLRAVCGIFHTRSRTEHSRKRRVMAHMFSPQSVRAFEPRVKGHLQTLLNQWDVMCSKVGAKDEVKAGTLGSSTWEVHDGYVWFDVRFWCNLFTFDVIGELAFGSPFDMLLRGEDTAKIAKSAKAGMASYGLTDAAKQPVAQYEVEEIAAIELVTARTEFVPALAVLPAYMREFMKRMPQYHRGGKALGQMIGMAADVVSRRLAAARDAENDAKIFDDMFGRLLNGRDENGNPMSPQELTAEAITLLIAGSDTTSNSMSAIIFYISRDQKVQKKLQVELDAAASADTTSILPFDDAKSLPYLEAVVNEGLRLFSPVGLGLGRVVPEGGITVLGQNFPAGTEISVPLYSVHHLEEVWGADVEKYLPERWLNAEKRGEMMKAFNPFSFGPRACIGRNVAMLEITLVIAAVFRRYDIVVQPGQVLEVHDNFVRKPHKFVVGIKRRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXG6</accession>
    <name>A0A401GXG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1001270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617796.1">
        <property type="nucleotide sequence ID" value="XM_027761995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXG6"/>
    <dbReference type="GeneID" id="38783800"/>
    <dbReference type="InParanoid" id="A0A401GXG6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="5632" checksum="9A5FECA7E84C3283" modified="2019-05-08" version="1">MPNVYVSEANGTVGRGHVDAPDFVRTAMLHVRCPGFPETRVAFDEVRKKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXI8</accession>
    <name>A0A401GXI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617816.1">
        <property type="nucleotide sequence ID" value="XM_027762015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXI8"/>
    <dbReference type="STRING" id="139825.A0A401GXI8"/>
    <dbReference type="GeneID" id="38783820"/>
    <dbReference type="InParanoid" id="A0A401GXI8"/>
    <dbReference type="OrthoDB" id="3070852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12842" checksum="10037BE127CE4210" modified="2019-05-08" version="1">MSNDSASEPPSSVVSFGSYADLHRSASSSTSCSSVDFGYNPFTSYGLLLGSGNQVWHPPMLPPDQSPRFIHPPMLPPDQSPCFIHPPMLLPDESSGMFLHPPMLHQDDTDTIRAQLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYB1</accession>
    <name>A0A401GYB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1004400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618106.1">
        <property type="nucleotide sequence ID" value="XM_027762305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYB1"/>
    <dbReference type="FunCoup" id="A0A401GYB1">
        <property type="interactions" value="672"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYB1"/>
    <dbReference type="GeneID" id="38784110"/>
    <dbReference type="InParanoid" id="A0A401GYB1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="528" mass="59649" checksum="6519F04E73EED72C" modified="2019-05-08" version="1">MSPFEPDRWIRQLMKCEHLSEVDMKALCECVRCILMEESNIQPVSSPVTICGDIHGQFWDLLELLRKGGEVPHTSYIFMGDFVDRGHYSLETVSLLLVLKAKYPDRVTLLRGNHESRQITQVYGFYDECQQKYGSALVWKACCSVFDYLNLAAIIDGETLCVHGGLSPDIRTLDQIRVLSRAQEIPHEGAFCDLMWSDPDEIENWAISPRGAGWLFGGSVTQEFNHVNSLRLIARAHQLVQEGYKYMFDEQLVTVWSAPNYCYRCGNMASILTIRENGGRDFTVYDAAEENERDKGLQKSRKMGNMTYFYYAAVNTSVILVSCNLSRVIVSLLAESPRGILQNGVEFVMGKGRMDSNRPSALDSTATSATDIEEPRDTTRGFSVRRTASRARTGMCMEDEGTSCMQRYSDALATMSHTLQVGHEYRQRPSERFHIRNSLSHYSPISLRVQCLASFASLSTPSPISIVCSMRHSLPGPRVHHTIARSNYSNRMLGEVLEAKHGHPRRPLNQHGHSDLRAAGHLEGERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYJ4</accession>
    <name>A0A401GYJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1004210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618087.1">
        <property type="nucleotide sequence ID" value="XM_027762286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYJ4"/>
    <dbReference type="STRING" id="139825.A0A401GYJ4"/>
    <dbReference type="GeneID" id="38784091"/>
    <dbReference type="InParanoid" id="A0A401GYJ4"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="735" mass="82088" checksum="F0FF6B2E853D4F26" modified="2019-05-08" version="1">MLANSPTSAMVEGAPTLPGLTPVQFQRWKPAISACNLDSALGYLGREGVRLSWAATPTNDMPHLSPVPLQPPTWVILYLICHQVTSPADAKKALVLAYYHLPTALPHLRPCLLIFSACWLAEHNLVVPLQDLIRRLLQSSCEWREYDYSAFLKLVAAASASPTGIRLIIPVLEASSARRLRLDQDTFDSLLSGQFATAELGIALARSMQSQATIPSVKNLERLVKLFAKAGWRKRAGRCLDLVRHHYAEQQTETVPFGTNPYARNVMQAPTLSQHWYMSAFGSVRSLHAYMQACGVHSRLWRAEPRIGTWRSVLRAAVRDRSLSAKSLLAILERAKASDSSLRLDVVSDLVTINGLLHRRDNTNAARIWDTIAAKKDRLEVWGLALGVKALTLAGRPSEAFALLRGIDTSRYSATSTQLLSRSEARQQITTHTINIFMASLQRIGRPDIVFELWDYMESLFGISPDQFTMAIVLKTARFASKSDQSVRGALADIGLGNFFRRKSVGDAPVSYPESSRSMAVARIQELLAQNRNDTNSGVWRGERAGVQALQVAHHILLGNWPELHTIQSPVHAVRRSLGFSPVGGLFRALSGRPSTPSQDDSRAAQQAPNYDIDSLWPYPQVLPNDVAFRAYIDLLGAENQMSEIPLALAWMRHLDVKPSRNTLATALVYWAEVSMDSPLVEHWKSERSEYLRLIRWMKEWVGSENLPTDADIGLHLGRIKWFRDLRYGRRPVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYX0</accession>
    <name>A0A401GYX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1100270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618265.1">
        <property type="nucleotide sequence ID" value="XM_027762464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYX0"/>
    <dbReference type="FunCoup" id="A0A401GYX0">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYX0"/>
    <dbReference type="GeneID" id="38784269"/>
    <dbReference type="InParanoid" id="A0A401GYX0"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="10">
        <location>
            <begin position="228"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1225" mass="131409" checksum="9EA33EA3965F960A" modified="2019-05-08" version="1">MRALLRPLATHNVNFPMESIVFIFVLAILAYFNTLDGVKHSRFLAPAYPATLRPAHARLSDNEWLGVSQRDWYGAWKHPQDGVKTVELQPLVFSLSDKKGSPEATLDRSVLSDIGKHLATEFPSASGQTYPSLCYRPSSNMSAVPCFTSTSDSSSMLTLAFLPESREDWVAALQHENAIIVDGAKYVVESVKREETIREMKSGKWVAYALRALVLRFWELAKKADSLDIFVVLMGYILMHATFLRLFFSSRALGSNFWLSNATFSSSFMAGLMTLPVCRYLNIPLDPVSLTEALPFLVGTVGFDKQLRFARAVMAHPHTFHTQDDGHMKPAGDVVLEALDMTGNVNLRDYALEIVMLLVGVNSGVGGLKEFCSVAIVALVMDCLMLSTFYAGALTVMVEVRRIKMVRAMCRSRSTSISAPTDGSAMRPALTHTVSKAEVPTQKSLKERVSAAVLGVKGSVLKDVQASKVSVKVENPVARLKLLLIASFLTLHILNFCTTLAPAGAHARQNRQSLRTSTDVVPLAPLVDITSPAIASVLASLAASEQEVVQNNESVDSELLVKVAPPVYVRVIPASPSSSPMSSSEAIEDFMSSWSRLAGDPVMSKLSVVFLFISVGLNAFLLKGIAAGSGLAAVRAMRSRGVRFRSRARCDPQLEKAPVCPPAAPVVVASAVPSTASITNALLPARESSAILSSPINLETLDQKLQERILRAPLTPPEEPLSPLSVLEGGLSRKESRMDNLRSLEQCIDIFESGPRPVSVSLSMLHDEEIILLAQNGKIAPYALEKMLGDLERAVLIRRALISRASRTKTLEYSDLPMTNYDYSRVLGACCENVIGYMPLPIGIAGPLKVDGEFFPIPMATAEGTLVASTSRGCKALNSGGGVTTVLTYDGMTRGPAIDFPSITVAAEARAWIESPEGYALLKESFESTSRFAKLQNIKCAMAGRTLFVRFATRTGDAMGMNMISKATEQALETMAKEFPSMVVLALSGNYCTDKKPAAINWIEGRGKSIVAEAVIPGKIVKSVLKTTVEALCNLNTKKNLVGSAMAGSVGGFNAHAANILTAIFLATGQDPAQNVESSNCMTLMEPTNSGEDLLMTVTMPCIEVGTIGGGTVLAPQQAILEMLGVKGAHPTNPGQNAQQLARIIAAAVMAGELSLISALAAGHLVRAHLAHNRSQLNTPAVSRPLTPAPSTPNLSGSFIWPLGPKGAMTPVSPTPGPYDVETKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZI3</accession>
    <name>A0A401GZI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1102370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618473.1">
        <property type="nucleotide sequence ID" value="XM_027762672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZI3"/>
    <dbReference type="GeneID" id="38784477"/>
    <dbReference type="InParanoid" id="A0A401GZI3"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="280" mass="30697" checksum="C68B0E38C1F25C45" modified="2019-05-08" version="1">MAHQSSGSSVIRRTISTTLSTVHQGVAFEKRSLRLLEENLSMSLRHVGGKSDGGIDLQGWWWLPEVALCLRSQSSIARHEQARRMRIRVLAQCKDEKKKLSPKYVRELEGVLFRYTARSSYGELSLSLRSTAPVDARTAESGLSPLDDGQDWSADDAENTSSPLVGLLISSSPFTKATLLRAHSSPVPLALLHIPSLSVPLSLTTVDQELHQERGEDANVVDSAHEIGSLVFNPALGSTSGLLRGRVQPRWERSLSGTGLSGRPGLWCDGQRLRSWTPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H071</accession>
    <name>A0A401H071_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1200030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618692.1">
        <property type="nucleotide sequence ID" value="XM_027762891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H071"/>
    <dbReference type="GeneID" id="38784696"/>
    <dbReference type="InParanoid" id="A0A401H071"/>
    <dbReference type="OrthoDB" id="2804106at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="533" mass="59479" checksum="47A68C92A5776320" modified="2019-05-08" version="1">MSQPSSVLTANKDGWYRPAVNTDAGVQSTFMALRNDLAEEFTVERMLCPHPTIPRSFIDSHEGLAASTHMDEVQPAPLQVDKAQGAPPGLDGSVPQLGSVGPKSLPLLAPTHHIEPRQPTPPPANIGGMAKESLAPALTVEVTAMQQLVEFIGLAVDQLVQKALSNFTPVLERQNEIIRQLAPLATLLPSARASTSAKNEGRSTVSHPTPNGEYDGGEEDNDDCDDAPISRVKRFRGERDNVFHDRFREYLKVKGLLPKARDSPLSPVPKPEIMQAWHDGEGDGPDVTAPLIEWSLPLSSAWNKEVIHIITEEFLKQVAGGEHPPLVSDPAWTITTASQCCLRTLQNGPHKRFTEVELMEDEEVESARNTAKKQRRKNSRRETVYKRRGDIIEVNLQDNPAIWGKVKIIHMALGQGGMSSDETDGEYTRRNDKKVRRVCLPWRHPSLAAFYRNVDSYEDVHPLHLTEQGNYSLSRIFEANVSSSSKRKLITQLPKNFYNPDWMKTITRAQRSTLQFKLAFEIPDLPEFAARRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0H4</accession>
    <name>A0A401H0H4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1201170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618805.1">
        <property type="nucleotide sequence ID" value="XM_027763004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0H4"/>
    <dbReference type="GeneID" id="38784809"/>
    <dbReference type="InParanoid" id="A0A401H0H4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="152" mass="17399" checksum="D6D966612448118A" modified="2019-05-08" version="1">MQSLLFANIRAIPRVTVSAAILVASALAFLRVADNWLSLEEDFKVTKGALNHAVHALDSLKQEDREIIQTRRPDRLARLEHLQTKLEELQRDVRTLETNMTLAAVWEQYLVRHDVIQQLKTITCLARAFDMELLGLLSRCRKLEQAGVKQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0L3</accession>
    <name>A0A401H0L3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation machinery-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1201560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618843.1">
        <property type="nucleotide sequence ID" value="XM_027763042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0L3"/>
    <dbReference type="FunCoup" id="A0A401H0L3">
        <property type="interactions" value="988"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0L3"/>
    <dbReference type="GeneID" id="38784847"/>
    <dbReference type="InParanoid" id="A0A401H0L3"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="39732" checksum="66FC854DD8DC418E" modified="2019-05-08" version="1">MPPKKQASGSSGSKPKEDKTFGMKNKNKSAKVQKQIAVIEKQQAQAGKSRAVLEKEKEKALREKAKVDEEKRKKEEGALFKPVQVQKIPPGVDPKTLLCQFYKAGMCEKGDKCRFSHDVNVGRKVDRKNLYEDSREEKMKDTMDNWDDEKLQQVILSKSGNPRTTTDIVCKHFIQAIETEKFGWFWECPNSDGCQYRHALPPGFMLKSQRKAAAEAEKANTISLEEFLEVERHKLGSNLTPVTPETFAKWKQTRMDKKQAEEEALRKAKDAQAAAGKSSGMSGRDLFTYNPEWFADEDEGEEDDWDLEQYRRQKEVEDLAAEEENLQGAEQNDGLSGDAENRGSDGEEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Z7</accession>
    <name>A0A401H0Z7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1202890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618973.1">
        <property type="nucleotide sequence ID" value="XM_027763172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Z7"/>
    <dbReference type="GeneID" id="38784977"/>
    <dbReference type="InParanoid" id="A0A401H0Z7"/>
    <dbReference type="OrthoDB" id="3266090at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="190" mass="21864" checksum="209DCA8B420D7D93" modified="2019-05-08" version="1">MSSLASDGYSWYERDENGNLIPDSGTGYKLTPAAVEAEREIYLKRAKERMPAPTTELPDKYNPFLRKDVKPKPPVLQYGIAVKFNQLRSYANEKNLLEPAARKRGVPLSSLSVMPVVYEAIHGLEVACNARLHWAIPWIAGYNGMVVLYSNYSIFWEQLEEEHEQEVIRILQEELGVTEKPMWYWDISNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H146</accession>
    <name>A0A401H146_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1203860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619069.1">
        <property type="nucleotide sequence ID" value="XM_027763268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H146"/>
    <dbReference type="GeneID" id="38785073"/>
    <dbReference type="InParanoid" id="A0A401H146"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="11273" checksum="928BB25950FCD9EE" modified="2019-05-08" version="1">MLLSLTGHRICSYWPWLWMCALRRRRDSDPDLEHGEMSLVALGRSSFALSIERATLIYEASTKRSLAYIYVVASSLFMASHYLLPQVHIFHSADSPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H153</accession>
    <name>A0A401H153_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1203740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619057.1">
        <property type="nucleotide sequence ID" value="XM_027763256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H153"/>
    <dbReference type="STRING" id="139825.A0A401H153"/>
    <dbReference type="GeneID" id="38785061"/>
    <dbReference type="InParanoid" id="A0A401H153"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="36536" checksum="235162CFEDAC915C" modified="2019-05-08" version="1">MSAQQKVLFLQSKQGKFAVGTTAVPTPGPGELLVKVEATALNPVDWKIQAGGFMITEYPAILGGDVAGTVEAIGEGATGFTVGDRVLSQGLIGHPTHATFQQYTLVYADVTAKIPSKLTFDQAASIPLCLATAGLGLFYPENLQASAGFLPPWREGGRGKYAGHPIAIFGGSSSVGQFAIQLSKLAGFSPIIATASLHNTELLTSQGATHVLDRHLSAAALQAAIAKITTAPIETVFDVIALQDTQNTAYQVLAPHGKLLLVLGDQVDPALKAKGGDKKIINVFGNTNVPANRQAGHYLYAQLTALLEEGAIKPNHVEVLPGGLAGIPGGLARLQADKVSGAKLIARPQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1J7</accession>
    <name>A0A401H1J7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1300550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619153.1">
        <property type="nucleotide sequence ID" value="XM_027763352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1J7"/>
    <dbReference type="GeneID" id="38785157"/>
    <dbReference type="InParanoid" id="A0A401H1J7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7844" checksum="7A8CB3E6621787D1" modified="2019-05-08" version="1">MMKKQLRTAGQRVRQADEYLQVILDKSRDFCKVSGFEFATEYEGVAGVNIKDEENDMLIAEGKQKETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1L1</accession>
    <name>A0A401H1L1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1301420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619240.1">
        <property type="nucleotide sequence ID" value="XM_027763439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1L1"/>
    <dbReference type="GeneID" id="38785244"/>
    <dbReference type="InParanoid" id="A0A401H1L1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="277" mass="31036" checksum="0627BE9B54090F1D" modified="2019-05-08" version="1">MSGPLSATPNSAGRISALRSSDHSLHASHCRAASDCSRQRLACSEGEISGLRLTSSPSESSRTNCTALQRKPYQLQPDILRYNSGIHLFAPLACKKGRVCPTSQTVASLACVAQGPHVHYFSVRNWRIPFGRSVTSTSLQCSMLEWKLKYQNDRQGRVESRTLFRRDVVQAQCVKSRKQARHLYVFNRVRPPAVVQVMPRSGAFRFILVICVFRWSSMSHPDRISPHPRQRLGNTLPHHVSGADPESLLPLTLRPPSQTRITREARLGVHPATWKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H208</accession>
    <name>A0A401H208_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1302800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619378.1">
        <property type="nucleotide sequence ID" value="XM_027763577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H208"/>
    <dbReference type="STRING" id="139825.A0A401H208"/>
    <dbReference type="GeneID" id="38785382"/>
    <dbReference type="InParanoid" id="A0A401H208"/>
    <dbReference type="OrthoDB" id="2803957at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="308" mass="34877" checksum="CD8F5F6B1DBC9622" modified="2019-05-08" version="1">MQALQLGLLSQQDDDDELDSQAQEAFNSMGKDEREELAYTFKVILGLMPGLKDQLVYMGDNINAIDVLGSYLNHYATGARGDHLGSLHERIVNYLPDFSDSYPVLKPQDSKWKRGFQNITTGRLLCLQSMLTEFLNDSDGFCRQVRDGEIDIPSDEFPSFLYDEALYNPDELDAGLLRHPLLLKCVSDHGNCESRPGRPPLTKKYDMTQVTPRNIAYLAVLVRFLLNSQHSWSNVDMTFDLEKFFFEILKFFQDEEWGKATLEWWNKAVFGTTAKGQGGMKKQTRPQSASAKLKVQRAARAAVQSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H275</accession>
    <name>A0A401H275_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1303090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619406.1">
        <property type="nucleotide sequence ID" value="XM_027763605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H275"/>
    <dbReference type="GeneID" id="38785410"/>
    <dbReference type="InParanoid" id="A0A401H275"/>
    <dbReference type="OrthoDB" id="3068541at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="132" mass="14537" checksum="F6A50E85D03E5AF6" modified="2019-05-08" version="1">MSSPLGLSQSYPLVDEDALDERLNEPSTEDDAQPSTSQLHHSPPTSQEDRWLGSDPLWLPPMLFHSSEFDNISTCNNAPPVTVHGPALPSDHLHQLYDDWGGIVHHGRPGIEETEDAQPPTLAQRAREMAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2N4</accession>
    <name>A0A401H2N4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619575.1">
        <property type="nucleotide sequence ID" value="XM_027763774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2N4"/>
    <dbReference type="GeneID" id="38785579"/>
    <dbReference type="InParanoid" id="A0A401H2N4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="26308" checksum="306019F45BB3E453" modified="2019-05-08" version="1">MASTSADIEGATEVTMPVTSDGAMILTSSVLGKAHSCPEDAVDAVESMGATFDIIYQAFPHAEVAAATSKLRMAYGSLFEGNLELQNTARNCFAALSQLFFHVEVSPGMIKGPNQACSIGTRPEYFQSRMEMMAAQFQDLHSMFFELSHLLCERCSPVEAGPSSQEQSKPYHLASITASWKRSLAGKMKQKHKIEVSLPSQSTKLGYNVCLEFWLILTYQDLSHGDDLGVKGSRSGPVPAAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Y6</accession>
    <name>A0A401H3Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1501530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620060.1">
        <property type="nucleotide sequence ID" value="XM_027764259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Y6"/>
    <dbReference type="GeneID" id="38786064"/>
    <dbReference type="InParanoid" id="A0A401H3Y6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="227" mass="24368" checksum="9B3B5152178AC2FA" modified="2019-05-08" version="1">MAQYSFAGGFVLQTNVTFSNYTVDRVFINALDVSATGVSGLLGLGPVSISLHLERMTAALSLPSSPPPVLLSSRLRPLSSQLGSSAFCGLTVLENVSALSTRGGGEVPRESRIVFQRSLPSTSTSGLGLGLTGIHDVRAMRELLCRHRRVCVLRSAGASRFSCVFGSIRLGSSFFVRLLPPLPRRPSVQLSLLRYHRRITSSRSSLPEERVVPSASIAPCSILYPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4L7</accession>
    <name>A0A401H4L7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620298.1">
        <property type="nucleotide sequence ID" value="XM_027764497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4L7"/>
    <dbReference type="GeneID" id="38786302"/>
    <dbReference type="InParanoid" id="A0A401H4L7"/>
    <dbReference type="OrthoDB" id="3062963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="273" mass="29224" checksum="B59EC880B8F0EA72" modified="2019-05-08" version="1">MATFYSSFFSSGLLAPQPHTPQPSSPSTPRQTYLNFDHEITPTALPGTNAPGPEPTLLPSISLTESAPTHDHGRRLRRRRSSLTASTSPLATIKSTTAHRTAAASVQRQSLIAGRSRSGSDASTFSMHSRGESVVEEMSVIRRLRSGSVGTALRPRRTLRRNAPPAPPPPTAPLPALPLPQSHLQAPTTPRRPLQRRVHTMDNASPVPYSSTLAVVPSSPCDSDYALPSSPGYPALGNASAASDLGMRKMQLDYPSPIEGEGCLWDQNAIKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4N4</accession>
    <name>A0A401H4N4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620274.1">
        <property type="nucleotide sequence ID" value="XM_027764473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4N4"/>
    <dbReference type="GeneID" id="38786278"/>
    <dbReference type="InParanoid" id="A0A401H4N4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="95" mass="9350" checksum="BCAEA9F324AAB6CA" modified="2019-05-08" version="1">MGARCLVRYSGSPQSGGTPGARGRASAHSLPELAPELASGATCLPGVRYPVERVPTTGASSQRLVGTVLMELADASASLAAVDSVRLAGGATAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4V1</accession>
    <name>A0A401H4V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1601040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620355.1">
        <property type="nucleotide sequence ID" value="XM_027764554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4V1"/>
    <dbReference type="GeneID" id="38786359"/>
    <dbReference type="InParanoid" id="A0A401H4V1"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="168" mass="18287" checksum="88B62D443C3BD479" modified="2019-05-08" version="1">MQVQDCLSLDFYVDWNIRAYNPGSLYIAGFAQSGDPHAGLILSIDSSKGYFAHIMIKNDAWTFQSREQNVARSMSLMSLLKIHDVSAGVITAAQLEAAACKVAVPPGSESGECLKWVLSIIQVLHAEGIITLTSVDNLTQEFSSFALENCSYAERSKFPNIGISAYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5F0</accession>
    <name>A0A401H5F0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1603300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620579.1">
        <property type="nucleotide sequence ID" value="XM_027764778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5F0"/>
    <dbReference type="GeneID" id="38786583"/>
    <dbReference type="InParanoid" id="A0A401H5F0"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="168"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="427"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="779" mass="87974" checksum="17479100319B156C" modified="2019-05-08" version="1">MPVDEFLKFLPETDMSAMPPARQAFKDVPAEAKYRQQIIEPLIIAINGAGADIAKKSPPRCPGFVFVDTTSFGVNCRDVGSMVPHVSGLSEEVIDLVKPKSTIHNCLGYTDLYVEVQPSSGLDAFTDPTLGRNRSSHNFIPNVDGERIRTRADRGLGRNIACATEACAHQHRSFYFSVSLSGSRARLIRWDRAGMIVSESFDLRYNAEFLCTFLWRYAHASYSQRGYDPTVQPATKEEEKLFKESIRDHVKFQLDLSKRTSLVAAMEEHYQPGNVVAVTMVDDNSIKRRLLISRPVISPVSMTGRGTRAYWAVSADNSKGEMMFLKDTWRCNGRCQKEGEVLEDLHRAGVPNIPQLICHGDVLEQRPRVNRINEVERRKNGDIAGDRVLQCTQTDQFQHAHWVCKHKHDQAPYESMMGAINIEDNAKRRVHRNVSLGNIILSRNPNGVNAARHGYLFDWELSCLVTNEGEARDPAKVGTFRFMSQRSLSWRPEAQTIQDDMESLLWVVLYCSLLWLDHDLPPQILSKTMVDLFDQRRVYRNGDVMAGEGKFCNQLQREHTSRVHFLNPVIQQWLDAVMDFNSSFVVGQPRGATVAEIWKDPSKFNVFWQDFLGAHEMFNHDRISRTLKLPRAHRRSSSSSTTSSSFETDLDTISRASSPSRDCWLSLSSSTTSSAPQTAYPVPVIPPSRKRKATGEPVGEDPENMIKFLVPSVPRADYTGPITRSMAKRRQTEAQGSATGFLHLPGQPRYNPRCLRPSPAKINMTDFARQGPKSSRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5N4</accession>
    <name>A0A401H5N4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Superoxide dismutase</fullName>
            <ecNumber evidence="9">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1700460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620635.1">
        <property type="nucleotide sequence ID" value="XM_027764834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5N4"/>
    <dbReference type="FunCoup" id="A0A401H5N4">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H5N4"/>
    <dbReference type="GeneID" id="38786639"/>
    <dbReference type="InParanoid" id="A0A401H5N4"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="11">
        <location>
            <begin position="102"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE89722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="209" mass="23143" checksum="55BC952F24EAF41E" modified="2019-05-08" version="1">MAAAATGQHQLPDLPYRYDTLEPFISRQIMELHHKKHHQTYVTALNAAELAYAKASTPRERIGLQAALRFNGGGHINHSLFWKNLAGASSEGKGVGGSLRDGPLKKAIVETFGSLDAFKKEFNTTTAGIQGSGWGWLGLNPSNKRLEIVTTANQDPLLTHVPIIGVDIWEHAFYLQYLNVKADYLNAIWSVINFDEAEKRFLEGTNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5N5</accession>
    <name>A0A401H5N5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1700830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620671.1">
        <property type="nucleotide sequence ID" value="XM_027764870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5N5"/>
    <dbReference type="STRING" id="139825.A0A401H5N5"/>
    <dbReference type="GeneID" id="38786675"/>
    <dbReference type="InParanoid" id="A0A401H5N5"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="185"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="355" mass="39578" checksum="DAD74E64DC1C12C3" modified="2019-05-08" version="1">MPSTILPPVRHHVPPTRTKENLDYADLAVIDLSKAHTPEGRALLAIELCDAIAAQGFFYAINHGYTQAQNDRMFDIANVPFSLADEEKRLYTGNVKESGTYQGFKPRQLWHIDGGVHDQVEHYNINRDVTKRQHPKAMRPFLPEIEAFAQFNHYSVVHTILRLLALGLGLPEDSLVDQHNFSTAGESSVRFMNYYPRTGDEETKTNNVWLKGHTDIGSITVLWSQPIAGLQILSPDGKWRWIKHIDNALVINAGDALELLSGGAYKATIHRVVQPPPDQCACPRLGVFYFAMPDDGVRLVPHARSSVGGGECVGAPTMEAWRKGRTAAYGLVPLRRRADGVEEETVEGVVVRHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4P1</accession>
    <name>A0A401G4P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608046.1">
        <property type="nucleotide sequence ID" value="XM_027752245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4P1"/>
    <dbReference type="GeneID" id="38774050"/>
    <dbReference type="InParanoid" id="A0A401G4P1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="264" mass="27579" checksum="8610DB9907C8DB99" modified="2019-05-08" version="1">MLHSISPCLPSTLLDPRRPAAANNGAPVITSASTFRLALPQTVERKHSAVRLLSEVEGQLSHAVVAPATAVQQRPAAPPRGRGGPSKPLSTSPHPPSALFDPRRPTAANDGDAVGASATAVRRRLSAPTTALPRPRGAPGSLSTSPHPPSAVFDPRRPTAANDSHAVQRWPRHKSAKASGGLSPPPCTLPRPSSTRAGPRRRTTAAWCNDAARQVCQGPGDLSPSPRTSLGPFQPAQAHSDERWPRDATTAPPQVCQGPGQPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4V2</accession>
    <name>A0A401G4V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0100440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608085.1">
        <property type="nucleotide sequence ID" value="XM_027752284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4V2"/>
    <dbReference type="GeneID" id="38774089"/>
    <dbReference type="InParanoid" id="A0A401G4V2"/>
    <dbReference type="OrthoDB" id="2758165at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019196379" evidence="2">
        <location>
            <begin position="16"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="282" mass="31083" checksum="394CFAB875BCA099" modified="2019-05-08" version="1">MKLWCLVWTFKLAALHDRTHVSSNNRRGFSASLNIKDGPLLEGRDESWPSDVQSLCNLLLQSRVLPSWVETGPHPPINPLVQPLLDELRNPDHGSGKSMDMIIGADATLETQFRRMFGTTLSDCFRLRNIVATENVSGNVDSKESFLLVAVRNAMSPDTPDLVISEGAKVALPRLSNTRLSPLFGYIANDIRAPLLMSVVTELSEPQHDSETIDELDESSTVAEPSIAQSLRSASHPESLEEQSHHATSVQPNEPNDESSGPNTVRSLRSSNLCFFLAWTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G585</accession>
    <name>A0A401G585_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA-dihydrouridine(20) synthase [NAD(P)+]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0101930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608233.1">
        <property type="nucleotide sequence ID" value="XM_027752432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G585"/>
    <dbReference type="FunCoup" id="A0A401G585">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G585"/>
    <dbReference type="GeneID" id="38774237"/>
    <dbReference type="InParanoid" id="A0A401G585"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="2">
        <location>
            <begin position="37"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="459" mass="50319" checksum="E06656BE35FE7F8B" modified="2019-05-08" version="1">MSRRPSSSSPTSSPRLAKRPRLEYEPLTPDDYKNGVMLAPMVRSGSLPTRLYALKHGASLVWSPEVVDKAILHSERVVDPVTGVVSYNGKSKAIFTTHPIEKPYLIYQIGSSDPETAIQAAKIVMQDVAGFDLNCGCPKPFSTHAGMGAALLTNPDLLCAILTALRQAMPPEISISAKIRLLPTQEDTLKLVERIVNTGVSALTVHCRTRNMRQKEKAVIGRLREIVEFVEGMGRGIAVIENGDCEGYEHSHKIREMTGAHSTMIATAAEANPTCFSPAPLVDLENTFIPSYMRLARYLGNHWSNTKFCTTQFKGIHVAGSRAGLKTFRETIVHAKSYEDMDPHIAPWTGEEVFAQIVRALEKRSGRRHLQALPEVVLDAQQEEAKENASARNVLEQTIEKTPLVGEVDPTILRAPLWPANELRIPLPAFVTGEDVPTPSPTPAPTAPRNSILFLASAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5B4</accession>
    <name>A0A401G5B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0102280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608268.1">
        <property type="nucleotide sequence ID" value="XM_027752467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5B4"/>
    <dbReference type="STRING" id="139825.A0A401G5B4"/>
    <dbReference type="GeneID" id="38774272"/>
    <dbReference type="InParanoid" id="A0A401G5B4"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019497343" evidence="2">
        <location>
            <begin position="20"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="122"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="467"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="747" mass="83253" checksum="B67C5E17FAE97CC3" modified="2019-05-08" version="1">MRVFLLLLLASFGMLLVDASSSDVQGIYSLVQRLIPQHQNSFTFNLVEGEGDVFTISDTSGSDGAITVDCTTTSACARGLYTYVTEFGGVDIYWTGSRLNQLPSELPPVGSPVSGSAIVPYRYFFNTVTFDYTCVWWNFDQWSLELDWLALRGVNLPLAWVGYEYTLEQVFLEAGLTQADIEDYLSGPAFQAWNRFGNIQGNWGGQLPQQWVDDQYALQQQILQRMSELGMTPVMPAFTGFVPMAMADVYPNASIIRGSQWSGYPSTLTNVSFLEPMDPLFVTLQKSFITKQQQNFNVTSHIYTLDQYNENNPLTNDTSYLAGVSAGTFASLRAADPEAIWMMQGWLFFINESFWTNSAIEAFLGSVPNDSMIILDLYSEAAPQWNRTDSYFGKDWIWCELHDYGGNIGMEGNLPAVTTGPITAFNYPGSTMKGMGLTMEGQEGNEIVYDILLDQAWSAAPLDINTYTASWVSRRYPVNPLPAAAQEAWGILSSTVYSNEDPNTQATIKSIYELAPNLTGLIDRTGLPTEIPYDTSTTIVPALRLLVQAVEENPALECVPEFVYDVVDVTRQVLSNRFIDEYNTLVATYNSTYATPDTVAAAGEPLLAILSTLDSLLATNKYFLLSTWIADARSWAGNNVTYANYLEYNARNQITLWGPTGEINDYASKAWAGLVGGYYTQRWESFITYLEDSVKNRTPYNGTEVADAMLDIGEHWDLEIWGQCAGETWGVTGNTWDIVNEVLDQWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5J7</accession>
    <name>A0A401G5J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0103200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608358.1">
        <property type="nucleotide sequence ID" value="XM_027752557.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5J7"/>
    <dbReference type="GeneID" id="38774362"/>
    <dbReference type="InParanoid" id="A0A401G5J7"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="616"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="687"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="773"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="868"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="930"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1284"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1555"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1287"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1560"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1582"/>
            <end position="1606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1647" mass="180998" checksum="898E0458FB965C5E" modified="2019-05-08" version="1">MFTVKATYRSETRKFSFADPAVFPSFEQLFHQLYRVFPISHSYYLSKLLFSPNSNNQRILIGMEAHSADEYNAHIAPYQGREWPGALLRFSVYDETPHKSPSASNSSLLVPSVTSDVGASPSGSAQSSTTFVETMDRLINTRKERDDRKFLLDRIRERTTSRNGVTFSSSPSTSSAIPRQPESSSRPLPQRPLSRCSSASTPHAPLRPSLFDLLSNDDVPKVTSLPTGANAGHDGSERCESSYPRLVDKMSAPSQPAYWVYQDPPLAPWPRPSPPPPVLYPSVGVLQLQEGSKGHRVDTDVIMSSPAVRSANLTPQTECAQPAVAHQQSMEQPEAPPQYISQTHSIPATSSRSAVNYCCSVTQGKTEVKDLMATFISDLDRTMKTAFGDDWASGAPSRSSVRSVPMDTGNEEERLKTRRQYRSLLNGSCGLSSGMPSEDERVRRHVYRNVLAPVLSEPIWNGLSDEERMKRRREYRSVLGSDPATPMAQDADERLERRRQFRTLFPHSPISVREASDLQNEDERLRMRGKYPDIVGGYYPHASTPSPGTTSNLPRMFSPAEPTTTATSRECNVDEVPMPGSFVAHPSRFGPPGRRVFSPALPPINPQETTGQEMRHVGITCDACHKSAFLGVRFKCLDCKDYDLCSACMSSPDARGRHSVQHAFFPIDTPCNFGPYARARAERHPIHPGMVCDACDEDISGVRFKCLDCADYDLCSSCFSAPSQREKHSLSHAFFPIEVPWNKDDYNRAREQRRAEVAPVAASPASTTAPLVHKNVICDMCAREVVGVRHKCLDCPDFDLCSECYNIAETRAQHSLQHEFFAIDRPGEVIVHTVFSGHGERTPSSWTPPRPQRSPSRRGSTTPVEPVVHNAVCNLCDSRIRGDRYKCLTCPDFDTCSMCFQITEEQHPGHGFVKISKPDCLMVRDVGGALHSATCNVCKSRIVGVRYKCMHDSCVDFDLCQACEALPIPVHPFTHPLLKMKDPHTSVPTVRRLLAEGAFRTEPEVTTCREKYREPIVAKVDSNSTQSTSERHFGSVFLSDAQQRRDTKEALTKVAADSTSLSVEQRLDTQFLSLAEKMRGKQGWQPHIIDLTATEPSSAERRLDAQFISSAEEMRGIQHEAPIIDAAEAEPSSAEQRLNMHFTSLAQDMHKHREQGTAKEHVAQVPTAAEHALDSHFLSTVQAMNGNKRGSDDSLGLLDKPDSILVDTDIPPLIPLSPVTFVPYEPEASSASVPYVALVDYSVPLDVPPLENVAAQVATNRDVHAAVEHPVSSLVDRLIDVDDSNDKGSQIGTETSLGGLTTPSDGPASNTSTNSVPRLGPVDNNEWRDLWPELTSMLKHLLQPPTPTGTVEHSVASEVAMPGAMHVEEPKDSAKTGPTDDADVHAAVEESPDRLSDYLGMPRPSNEVTGFTYAVPAEIQAPLFASFISDNNIPDGQVFPPGAEFVKSWRMINPGMSDWPETTELVFVAGDRLGSHGDAPRKVKVGTVKSSAEVEVVAGEMKAPEIPGKYVSYWRLDDGKGNLFGHSVWVDITVAEVNRATSELSSAEESLAASSVIMPHSTSEPAVEQRSTTARSLSVTIPSGPTSDSGSFDSSASLIDAPSSPFSDDDDDAVYEDSRSHDIVSPAQPRQETEYVMLYESSSSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5K9</accession>
    <name>A0A401G5K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0103250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608363.1">
        <property type="nucleotide sequence ID" value="XM_027752562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5K9"/>
    <dbReference type="GeneID" id="38774367"/>
    <dbReference type="InParanoid" id="A0A401G5K9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="15829" checksum="BF6A08E885AA8CB9" modified="2019-05-08" version="1">MGMKTSDTSSDTPLMEYPHPPLAHRQNQFPFDLALLVRTYPVDDLRYPNHLSRLHPLLRVAVIPTGMDVSPNKDHEPAGGHATDVEEIIMSATAPDDDEDHNISCGTRNVRRELMLQRSPLVARLFFFFSLFPLRYQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G803</accession>
    <name>A0A401G803_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0111760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609205.1">
        <property type="nucleotide sequence ID" value="XM_027753404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G803"/>
    <dbReference type="GeneID" id="38775209"/>
    <dbReference type="InParanoid" id="A0A401G803"/>
    <dbReference type="OrthoDB" id="2575000at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="237" mass="25070" checksum="D1B2086BCB4A1642" modified="2019-05-08" version="1">MIAGVSKAITQHLAPVLALTSLLLILFSYLAPVVMLSSRVALLSVTPSTSLVQSNSSQGLDGPTVFMGALGSCYRPNKETGLVCTSPTVSPTYNLSVLPANAPDLLTSPPSTSSAFIAVSLAFSFLFFFMFTLTTHRAHLGRAGAPFEKPMVQRATAWIGFMGFIIGLTSFLVIYMWFGKAVQDFNDDISKTGSGAPELIAATSNGFVMVWVGYSFYAVPLVCALAKLHIAATAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8S8</accession>
    <name>A0A401G8S8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0114320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609456.1">
        <property type="nucleotide sequence ID" value="XM_027753655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8S8"/>
    <dbReference type="STRING" id="139825.A0A401G8S8"/>
    <dbReference type="GeneID" id="38775460"/>
    <dbReference type="InParanoid" id="A0A401G8S8"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="935" mass="99599" checksum="D58FB5607BFEE0AC" modified="2019-05-08" version="1">MSDTTLIDDAIRVVVAPSQASYFAGEPFSVTITFTNTRTQELPPARSASHSVSSRHKRTAHSISSVPLARPPTSPGNPRTAVPTLLARTAGVSDISTRKGLIGQKQLPAGTDESLDSMDPMRKRVLTKSLSISVLSSELEEQSQDDLKSKASINSLRVTESAYASPTSPRTSSPLARSASLPIAPSHPHARKQSILDGQLQPQELRPPVLQSPFTTSPSTSSSSFSLSLDPIAESSSSPVPPMTPFAPSPVPDSTLPTIRTQLSSTSTETTAATNGSAKYVVRPSRGPPRRPPQLGHGPPPVALNNQPSRTTFSSSFVPPNSELILYSYAQLVGTLAISPVPGSTTTAQQAQTLSYLRSNLLKRKGVGGGSMDITSSMSYHAYSASSSMGTRGSHGRSSSLSAGLLSLLSPTSLMPSSPAPQPWMPSQRPQTASVFSLFSNGDNGGPIGLGLGVAEEETDPELPLPTFEVQPSLLAVDLSLAPGESRTYTYTIVLPAELPPTHKGRVLRFSYQFILGICRSPSSLPSGGLGPTGANSSSRVMKVPIRVYNNVVVGRAPMPYDLLWPCKARGSQFSAKVIEESRIAAKKSDLAPLQGVPASRSGTFEDLQVYARGLLAVFHHPSTGGVRLDLPVDLERDREREEAGGLTGCRQAVEILTRNPKKASYDVNKDGVKVAVLTFTKSAYRLGETVLGVVELNERSSRARVLKLSAMLEAHESLPSAISSPASSRQTRRVHAEHHSSFVVSTLRTTFSLDIPPDASPAFQVTIGGEPGDSARQIGAQPGGLEWKVRLCLLVAVASPTSRQSADGLRLKHLVKDGPRGEWGTSWKAAASIAPLERPDLRVHANPFGASEQAATTPSTARSWMSYLASSLLGPANEGYHDGDELADSDDDDNEEGSEDEWRSVRTEMVECEVPIRVWPGNTAFKATEVVFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8W6</accession>
    <name>A0A401G8W6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0114720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609496.1">
        <property type="nucleotide sequence ID" value="XM_027753695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8W6"/>
    <dbReference type="FunCoup" id="A0A401G8W6">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="GeneID" id="38775500"/>
    <dbReference type="InParanoid" id="A0A401G8W6"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="190" mass="21412" checksum="FDB0C0E0A9E93564" modified="2019-05-08" version="1">MSSAHNLQQHPVVIQVRDKASYYVNQLDKELSKHSAFTAFEKRTQIPKSYAFLVGLLLVTLFHSVNVLAAPVSNLIGWALPAYFSVKALETPGHQDDIQWLTYWIVFGFFNFLESLALGPILYYFPWYFVFKSSFILWLQLPTFRGAQSLYGSVVKPVFANVHSKANSAPTTESTVTADGLRERVATATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8Y8</accession>
    <name>A0A401G8Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0115290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609553.1">
        <property type="nucleotide sequence ID" value="XM_027753752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8Y8"/>
    <dbReference type="STRING" id="139825.A0A401G8Y8"/>
    <dbReference type="GeneID" id="38775557"/>
    <dbReference type="InParanoid" id="A0A401G8Y8"/>
    <dbReference type="OrthoDB" id="10256233at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="262"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="556"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="739" mass="81204" checksum="A005A86D04DD5783" modified="2019-05-08" version="1">MSLVNAAIRHRACLPAEVGASYFHTTSVPLLEKGRAPRSRPVKYNTPPKTSPSRTRLVKDLTPRTNKNEKGKGKAGKLEVAPRAAFVRDPAPHPDARDMREERERQRELTRRFGQRRLRRASQEKPRRSSSWDRDRDRDRDTAQSARWQEKKTHPLATRGLPDFDKPWRTSRGVTPPAAARGAEDGYAPAQRKTPVYNPLSDEFDVASKSVSTRELPGEFASPPLMEGLLTSVVDVLGPHAKPTPIQALALKHLFTPLKGEPGGKRRWHQCLLASETGSGKSIAYMLPMLQGLKQSEVNAGTSTAAAPDAPAPSTPLNPRALVLAPTHELARQLSAFAKALLHGIKLRVLCASQANLPSTPRHQVSAAQMARDADEGGEFGVHRGAAGHPVDVLVGTPARVLEMAKGRGWDFEQPKAEDHWGLDEKGRAARRPKAWTVGKPEMGLSRVEWVVVDEADVLFDPDFQESTRRILAEISVARGHPVPFEEGLPQDAPQKPLDYPFNLLLTTATIPSALASYLDTHHPGLMRLASPHLHHLPQTLKTEYAAWTGGNRYADIEHRLRRVWAEDLMAGGGRRSKVLIFCNKSTKVQDLGRHLNEKGIPNVALTSTSDTRKHGSNHHLDGFLRVRGEEGKETEGAREVGEDEPHVMITTSLLSRGLDFAPDIRNVFIVDEPRNMVDFLHRAGRAGRAGALGKVVVFGKAKGRGGRESVTLHRFLLSDMGAHDVGAIGRTHTPNAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G954</accession>
    <name>A0A401G954_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0115860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SERF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609608.1">
        <property type="nucleotide sequence ID" value="XM_027753807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G954"/>
    <dbReference type="FunCoup" id="A0A401G954">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G954"/>
    <dbReference type="GeneID" id="38775612"/>
    <dbReference type="InParanoid" id="A0A401G954"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040211">
        <property type="entry name" value="SERF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13596:SF0">
        <property type="entry name" value="SI:CH211-39K3.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13596">
        <property type="entry name" value="SMALL EDRK-RICH FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="67" mass="7442" checksum="C66ED6FCD4399727" modified="2019-05-08" version="1">MTRGNQRETDRVKAQKKATANKGKPKESASSLQQRREKDAEILRLKQKKKEEEKAATTSSGGDGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9N3</accession>
    <name>A0A401G9N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609781.1">
        <property type="nucleotide sequence ID" value="XM_027753980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9N3"/>
    <dbReference type="GeneID" id="38775785"/>
    <dbReference type="InParanoid" id="A0A401G9N3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22048" checksum="9DD6A8DE9D0967E1" modified="2019-05-08" version="1">MAIDHPGYVVYPSSTPGPFASTSTLGCLTRQLARYLDVPGAWFAKECVVDRAVHSLALMLPRFSSRSGSTFQSSPNVCPRYQVKPPAFGAPMVLRDVGRHSQRDGTSARLLYGTSVSKASFSKRSSVSSSQGGKGASRALTIPVKLVPIYVITEQLVDNRTGQLHDHSGNKRQGAPQYNTYRTVMLDKVYFQSSMLDTCKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9X0</accession>
    <name>A0A401G9X0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0201480</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609864.1">
        <property type="nucleotide sequence ID" value="XM_027754063.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G9X0">
        <property type="interactions" value="649"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9X0"/>
    <dbReference type="GeneID" id="38775868"/>
    <dbReference type="InParanoid" id="A0A401G9X0"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="244"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE78951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1403" mass="155853" checksum="E2786942A4144F41" modified="2019-05-08" version="1">MKESVSHQAPKVIKKLQFSLLNNQETVKISEFEVTHRDLYTPTDRLPVKDGVLDRRLGTTEKNAFCETCGLSSVDCVGHYAYIKLVVPVFHIGYFKHTISILQCICKTCARVLLEEPDRRGYLKRFRRPNLENIQRLALCKAVNTQARKTVYCPYCSATNGAVKKAGALKIIHDKFRAKKTADEMERWKKTFTPAVEAQKELGIYINKAVHEDLNPLKVLDLFQRISDEDCELLGLRPEFGRPEEYIWQYISVPPVCIRPSVAQDGASNEDDLTVKLTEIVFTNALIKQGLAKGSPTAQFMEQWEFLQLSVAMYINSELPGVPSQMGSKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPERIAKILTYPERVTSHNIEILKKAVRNGCDVHPGANYVTAGSSGFKKYLKFGNRTAIADGLRIGDVVERHIVDGDIVLFNRQPSLHKLSIMCHRVKVRPWRSFRLNECVCGPYNADFDGDEMNLHVPQTEEARTEALELMSVKNNLVTPRNGEPVIAAIQDFITASFLISRRDRFFDRREFTQICSYFGDADMQIDIPPPTIWKPVRLWTGKQVFNVLMRPNKKSKVLVNVESKCNTQEKPDPKYYPRMSPALDLAPNDGWLVIVNSEIMCGVMDKATVGSGKKKSVFGVIMRDYGPQEAAAAMNRVAKLCARWLANYGFSLGINDVIPGPILSGKKDSMVEKAYADCQNLIARAKKGQLENKPGCDQEQTLEAEISAVLSNVRENVGKICMNELSRHNAPLIMATCGSKGSVINVSQMVACVGQQIIAGHRVPDGFQDRSLPHFPKKSREPPSKGFVRNSFYSGLTPTEFLFHAISGREGLVDTAVKTAETGYMQRRLMKALEDLVTHYDSSVRNAVGGVVQFRYGDDGLDPACLEGDAQPVEFLRAWSHASSIGSRSSRGLLPFEIMELVDRELSNRRFTSECTAAYIATIRGFVMEHVANKLAEVRKNHGMFEALEREAEWDADTDLSLGASDADKATVDNKAKVTGEQVLTFLNICWTKYVKAKIEPGSTVGAVGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINAAKAISTPIISCKLVTSDSEASARIVKGRLETTRLGDISSVLEEAWAPEYTYIGVIVDLKTIQDLQLELTLDDIKWAIVAAKKLKIKQESITVVPRKHRLRIYVDGQDKYYRLRELKRALPDVVVKGVPTIHRAIINIKEKDDARGKKGDKELLVEGYGLQKVMVTQGIVGEQTSSNHVIEVAQVLGIEAARRTIINEIQFTMQSHGMSIDPRHVMLLGDVMSYKGEVLGITRFGVAKMKDSVLMLASFEKTTDHLFDASAFGKTDSIAGVSESIIMGNPAANTGTSMPALVVPAPAISKPRKLLFEGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA31</accession>
    <name>A0A401GA31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0202220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609938.1">
        <property type="nucleotide sequence ID" value="XM_027754137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA31"/>
    <dbReference type="GeneID" id="38775942"/>
    <dbReference type="InParanoid" id="A0A401GA31"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="819" mass="92529" checksum="81191CD3F90B008F" modified="2019-05-08" version="1">MGPTAPYSPSQNGVSERLNRTLLGLARAMIYARDLPRYLWAEAIAHAVYIKNRSPTQVLNGATPEEKWNGTKPNISYLQEFDSPVWVLTEDATLSKLAPRANKYIFVGYMDGPKAIKYYDAHMCQIKISRNFQFSSNSPDHLPGNAPHVPQEQIGSDVPILTAQREGEQNIFPGTLPSNASDVPHAERRPEVPNLTTTADVRREGELGTSAPQSPAKNPRKRRQDHDPDQRKESGTAAPSQPRRTRRKTVQHDYRLMHDPEADEDLDNDSDKSNAELVYIAMSVHRNADADEPKTLSDAKRSLEWPKWEQAVQMELNQLQGMETWELVEPPEDRKPVGNKWVLVKKTNKEGEIIKYKARLVAKGYSQIPGMDYTETFAPVVRLETIRAILGLAAILDWEIGQMDVKGAYLNGTLKEEVYMRQPEGYSDGTYRVCKLKKTLYGLKQSGREWNIVLNRKLLDAGFKRLFSDPCAYIRIKGDKIEIVTVWVDDLLIFTNDCALMDQLKRELRNMFEVTDLGEPRKIVGIEIERDRSKQTIKISQTKYIESILHKNGLTNANTVGMPLDPNTVLEKEEPKTDDECDRDNGYASLVGSLMYAAIATRPDIAHAVQRLSSFTANPGMAHWTAAKCVLRYLSGTRELGIIYGPIADVKPEDQSIFVGYSDADYANDIRDRKSISGYLFKLGNGTIMWSSKKQTTVASSTTEAEYMASAEAAKEAVWLRTLFKEIGFEQQDPTILFEDNTAAISIARDPQFHAKSKHFDVKHHYVREKLRDKYIDIHYCPTEDMIADILTKSLPKPRHEKLTKKLGMPIGLRGSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAR6</accession>
    <name>A0A401GAR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610189.1">
        <property type="nucleotide sequence ID" value="XM_027754388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAR6"/>
    <dbReference type="STRING" id="139825.A0A401GAR6"/>
    <dbReference type="GeneID" id="38776193"/>
    <dbReference type="InParanoid" id="A0A401GAR6"/>
    <dbReference type="OrthoDB" id="4743193at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="6"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="176" mass="20178" checksum="E86C8CB9588891BD" modified="2019-05-08" version="1">MKFVNLHPDPPHHSGLNRRQCFNRWKFIYDLVQHGPEYFHAFEKELTEPEMLEQIPLVKSRQVPVRGMDINQSTVQGNADALEDLFQQGEVGDSTAKPGCRDVGDHVVLVHGDLATCERVQSLQQSRGEEKTPWCRFQFIVFVIGLFHLKMACTDAIWKILIKLKVAREDVASHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBT0</accession>
    <name>A0A401GBT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0208190</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610532.1">
        <property type="nucleotide sequence ID" value="XM_027754731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBT0"/>
    <dbReference type="STRING" id="139825.A0A401GBT0"/>
    <dbReference type="GeneID" id="38776536"/>
    <dbReference type="InParanoid" id="A0A401GBT0"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="810"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="854"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1200"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1228"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="210"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="300"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE79619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1271" mass="136206" checksum="F79AFDE806BE388C" modified="2019-05-08" version="1">MRHNTYPHRPPTSSPLARGMGSEHPTKTFTASGGEVHTTIYVSNLHCSSCVQTIQDALWSLSPAPTSIDVSVVTQLVTVRHHPGLSQSAIEAAINEAGFDMATTSAVTVDQLPRFHSLSRLPALITGKSQKHLEQCSLCQEEYPLQCRVGGGSPITLTRPTSGERTLVAASDTRKELEAPSVLKISQDVSVAPSLDRASVSYGAKSSGIHHLTLSVGGMTSASCSNTITELLSRLPGVSDVVVSLLGNSATVTVEQSDFAPTVVETIEDAGYEAEVVNMEPVFVAPGPRDVSPSDTCGAQRVILSVGGMTCASCFNTVTDVMSAIPGVSDVVVNLLGGSAIAVVDSKDLAAGIVEAIEDAGYEAEVISTEAIEFTQGENDEETSGPRTVSLRVDGMFCYHCPGKVMSALSSFENRIVVLKAVTSYTDPILQFSYIPDPPSFTLRTLARAVSNSSLGTPFTVSVHHPPTVEARARQMQQYEQLHLLQRLIFAVVVAIPTFIIGIVYMSLVPSTNKTRMWFERPMWTGNVSRAQWAMFFQATPVMFYSAGTFHRRSLKEIWALWRRGSRTPIWRRFVRFGSMNLLVSTGVSVAYFASIALLALAATRPRSSSGPGDTTTYFDSVVFLTMFLLAGRFLEAYSKGRTADAITALGKLRPTSALVFEDASTVTSTETSSYAENRDLDIEKGDPSRQEKAFSTSRSGTKLERVDVDFLEIGDIVRVQHGASPPADGTVVAGEGAFDESSLTGESRLVKKMSGDPVFLGTISTRGMVDVRVDAIGGETMLDRVVKVVREGQTHRAPIERVADLLTGYFVPVVTLLAIITWVVWLGLGLGGALPQDYLDIDVGGWTVWSLEFAIAVFVVACPCGIGLAAPTALLVGSGLAAKFGILARGGGEAFQEAAQLDTIVFDKTGTLTEGGEPRVTDAEIADTRWSREVLLGVAAEVESASSHPLALAIRQYCADNEALPQTGSAFEETPGRGLKALFEALHSTAIIGNEEWMTAHGLSIDGKIANSLDRWKSEGKSVVLLALRHSKAGETPFMLSAIFAVADPLRPEAKGVIAHLHSQDIGTWMISGDNIVTAKAVARSVGISETNVIAGVLPHEKAEKILWLQQAGMKKRQAGWRRFLGRRRLNDRCIVAMVGDGINDAPALAAADVGIAIGSGSDVAISTASFILVSSNLRSLLTLTDLSRKVFNRVKFNFLWATIYNFVAVPIAAGVIYPAGHARLSPVWASLAMALSSVSVVCSSLMLKLYREPSPQAKQREDSLRSDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCL6</accession>
    <name>A0A401GCL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SDO1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0210990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610810.1">
        <property type="nucleotide sequence ID" value="XM_027755009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCL6"/>
    <dbReference type="FunCoup" id="A0A401GCL6">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCL6"/>
    <dbReference type="GeneID" id="38776814"/>
    <dbReference type="InParanoid" id="A0A401GCL6"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="124" mass="13370" checksum="CE5F415E9D8CD824" modified="2019-05-08" version="1">MPKSLTKVVYKPDTQSTDQFIIIVNPAEYHRWKAGETTIPLTDVVDSFQVFFSNQGSQGILGQASRQQLEHVFDTSKDLDVVQLILQKGKPEAADAISSGGSAMNVGIGSFTVDTRGKSLSGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCM8</accession>
    <name>A0A401GCM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0211090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610820.1">
        <property type="nucleotide sequence ID" value="XM_027755019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCM8"/>
    <dbReference type="STRING" id="139825.A0A401GCM8"/>
    <dbReference type="GeneID" id="38776824"/>
    <dbReference type="InParanoid" id="A0A401GCM8"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="5">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="542" mass="59352" checksum="C32489E5274150C8" modified="2019-05-08" version="1">MSRQPSPGPSHLSLQPTYHSPVVLANPAFQQPKPQRQKAYVSGITAGVEDVKYQAKYKDLKKKVKEIETDNDRLYFKLLLAKKNIRRMNLERAILYERLAAVPPTPGRHPQELPLVEDPLFHPQAPLPPESMIDPSDHALVEYMRTHPNARLIQAPDGRVIAVEDTPAPIVHGEVNTMIPQPPPHELPLVHSFHHDSGPGYDPNRQLPPLPPMISPLRAPESPSQGLPPMGEHHHHHYPPGHPHAHAHTSSHSSSSSHHASSARPDLDALAGGSRMEPLPMHSRSPSTGDDRRRPAPLPVPTHPQMPASPPPSAPSPTSTRSTGGSIGGNSRIHNHQRIGPGANIHREMAQREARELEALRQREMEAELYERDVAYQSRMDVEEQDEAAATGAAQWRNDAPLVGPGVSHGTSRADTPNGNSANRTPTRPASGEAYEYDREHERSRSYGSRVYEEHEDRAAHMPPVDVGAVAMESRKRSRSDIEAGDDYDGEIRSPIEGGAAGRPSPLSGSSASDGRAAKRMHPGDDEGGSGERRDEPMDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD13</accession>
    <name>A0A401GD13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0212370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610948.1">
        <property type="nucleotide sequence ID" value="XM_027755147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD13"/>
    <dbReference type="STRING" id="139825.A0A401GD13"/>
    <dbReference type="GeneID" id="38776952"/>
    <dbReference type="InParanoid" id="A0A401GD13"/>
    <dbReference type="OrthoDB" id="2986975at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF6">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 3" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="504" mass="56561" checksum="8313D2545F3AF65C" modified="2019-05-08" version="1">MILYGEGGTGKSRVIQTVTEAFVTKGVDYMLVKSAYTGVAASLIDGKTTHTIAHLSIGSDGTISDDSKVVLQEFWRNRQYLIIDEFSMLAKTFLANLSNTVSVGKEGTPHRKDRFWGGINVVLCGDLHQFPPVAKGASEALFRPIGVRDSDDCALGRMTYEEFTTVVILKEQMRVTDEVWRKFLAHLRHGNVQPRHIDMLRSLIINQRESPHTDFDSAPWSDASLVTPRHAVRKMWNAAAVRKWCRKSGERLFVVGAEDSCKGRPLTVREKYAVLMRNKDKRNRSHKKDLPEQIELAKGMKVMVTSNVETDLDVANGARGEIVDIVLHPDEPPLGPEPVVNLMKYLPAFVLVKLSRTRATTLEGLGECVIPVEPMAMSMRIKVDLPGGMVGHRYVRRKQFPVTGAYAFTDYQSQGQTIPIVIVDMKTPPPPGTLSLFNLYVALSRSSGRSTIRLLRDFDPELLLKQSHDPDLLAEDDRLERLNEQTKAWWVEMGHCISRDPSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDM7</accession>
    <name>A0A401GDM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0214840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611180.1">
        <property type="nucleotide sequence ID" value="XM_027755379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDM7"/>
    <dbReference type="GeneID" id="38777184"/>
    <dbReference type="InParanoid" id="A0A401GDM7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="62" mass="6642" checksum="FF03C15F2D722FC8" modified="2019-05-08" version="1">MDLHESEGRPTRTHEELGGRKHTPNLACSLADVNAANPVPATPSESAPKWPLNTVDDLVGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDW1</accession>
    <name>A0A401GDW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611279.1">
        <property type="nucleotide sequence ID" value="XM_027755478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDW1"/>
    <dbReference type="GeneID" id="38777283"/>
    <dbReference type="InParanoid" id="A0A401GDW1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="292" mass="33029" checksum="094B7C2340513072" modified="2019-05-08" version="1">MTQLSYFKPRSCYANAGVCWHLVRRVLSKDEEEYSRASVTPQFYVQSWNGELVAPLWAAVNSAVHSKLVPLGDTPDQIEHRWITIGRSCLFNVASDRLWRDAEWAERNWAGDKPKHWEKLHELAELLRVRLQGVSSIPTWPRMSILLWTTHYEHKPHILSNLKCADVPTAAAGNFAMLKLTLLQAGHGFTFRLCIKMCSHSAVQPTGLQRQLALFREQARNISAPPSHMGSCDALVVRSPSLHPDVLLGIANTAMGIPLVLRPAVQREPSGAWREEMELVDQEMYRLTMFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEF2</accession>
    <name>A0A401GEF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611472.1">
        <property type="nucleotide sequence ID" value="XM_027755671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEF2"/>
    <dbReference type="GeneID" id="38777476"/>
    <dbReference type="InParanoid" id="A0A401GEF2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="339" mass="37500" checksum="4627CBC9A359AF17" modified="2019-05-08" version="1">MFPPVSDDALNAVNTACEYAAKVQGKKPRSPLKFTPGELLKRGDKYRDSSMRMLTTNRKIVDPVTHGVSHKEYDQLLSKRDELISYTTLEALQNRSKFKDYKNDEKELNRVLVRSSQRSCSKYIWREKNRQLWTNSAVSEEQESSNPSSSNTEDPEPRSPVDGTSSDQGLAGAEGTHATPHVKRNLLQTIKDLAHILNPFGDHHTVDEFHHRNGANSAIHETSPDNDGEGETSRDDRGQDEISRGGGDKGETIRDNNGVGETSRQADIEGETSSDNNAEYDATVSLCSFTSDNSAGPSGTTQAILSLDDYSRTSCDGQGFQGFQGFQGRQKDFFLDSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEL2</accession>
    <name>A0A401GEL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0302960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611494.1">
        <property type="nucleotide sequence ID" value="XM_027755693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEL2"/>
    <dbReference type="GeneID" id="38777498"/>
    <dbReference type="InParanoid" id="A0A401GEL2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7652" checksum="8C6D7D53AB714B12" modified="2019-05-08" version="1">MLILVVIIRQDVLHHNIISYFAPVLVQPAGSVHTSTPTMQSKCPRVRQYVGCPKDHNLAILGTPKVHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEN0</accession>
    <name>A0A401GEN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">X-box-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0303160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611514.1">
        <property type="nucleotide sequence ID" value="XM_027755713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEN0"/>
    <dbReference type="STRING" id="139825.A0A401GEN0"/>
    <dbReference type="GeneID" id="38777518"/>
    <dbReference type="InParanoid" id="A0A401GEN0"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052470">
        <property type="entry name" value="ER_Stress-Reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542:SF1">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="410" mass="45186" checksum="5D4B0E2D685F4D64" modified="2019-05-08" version="1">MGGQRIHSLPVDELKRPSALPKTGNYAKQPTTATGDVAGRVRSLPHDFHVRPASLPQSPTHTRPALPFSSSRHVSRLPSHASHLPSRAMKRTADSDIELALPSPAASTSSPTPSVSELPGNTNLSTTTELGAPPRKRARGETSVEERKEARAHRNRIAAQNSRDRRKAQFAYLERRVAELEEENRQLRAGMGLVGLRRPQENSDRTRDQERERDAARDRENAELKERIKTLETGWDAVVKALAASGLPLNVPSIAPSASDPAEPPSPSSQPPTTTFSVFVPPSPIFPISPPPSHDSSLSSSPFLDLPFDDAEPTRHLARVANTDAPPLSSVPQQRVGPPRRPTPTSSSSSLTPFPPFQAPKHHLRQIWTRAPWRTSSAKSSRPRPCSRKRPCLILRLSPPPHHRRRPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEP8</accession>
    <name>A0A401GEP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Copia protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0303570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611553.1">
        <property type="nucleotide sequence ID" value="XM_027755752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEP8"/>
    <dbReference type="STRING" id="139825.A0A401GEP8"/>
    <dbReference type="GeneID" id="38777557"/>
    <dbReference type="InParanoid" id="A0A401GEP8"/>
    <dbReference type="OrthoDB" id="3344688at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17768" checksum="7C0B2E392FFA5A36" modified="2019-05-08" version="1">MNELVGYKDTDWARDVDTRRSVSAYVFQLGNSSIAWSSKRQMTIASLSTESEYMALSYGAKQALWYRRFLTEIGLTLGGTPTALLTDNMAAKDIAKDTHHHGRTKHIDVQHHFICERIQDGNFNVVHCPTAANIADGLTKPLDKEPFSKMVSDLGLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF29</accession>
    <name>A0A401GF29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0304600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611654.1">
        <property type="nucleotide sequence ID" value="XM_027755853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF29"/>
    <dbReference type="GeneID" id="38777658"/>
    <dbReference type="InParanoid" id="A0A401GF29"/>
    <dbReference type="OrthoDB" id="5386199at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019402840" evidence="2">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="184" mass="20681" checksum="5E802B5B35DEA65C" modified="2019-05-08" version="1">MFSLSSLGLTLAVTPLMFIMETTSALPLTGRFVLAGIAVATSGVSTALISWCGKPYVTKLRWLEPEGTPKESTRALEMTTFTLRLRERITRVYDTAFLVPASRPFATWELAEMFQLPRAEAAREKSAGLLPREETIAETTNKDGKVIGRWIVNWSEDGMGRCREIGRVARYFNVHEELLDRPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF53</accession>
    <name>A0A401GF53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0304740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611668.1">
        <property type="nucleotide sequence ID" value="XM_027755867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF53"/>
    <dbReference type="FunCoup" id="A0A401GF53">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GF53"/>
    <dbReference type="GeneID" id="38777672"/>
    <dbReference type="InParanoid" id="A0A401GF53"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="281"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="799"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="827"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="863" mass="97067" checksum="0C278D2DE56EF287" modified="2019-05-08" version="1">MAPSPSTHHSQSRTRAIRSFLVHHLNFYRVHILFFLFNSVSAMTVCGISTVDLSGLTAFQQVLLFIQMCLGSPVAVSWVMVYTRRSFFARKFRHMIGVDLARGIAAEVHAPVQVTLVPWWRRALNMLHPGGRRSYGPDFKGSDSLDRCSSPHVRPDMIRRMDDAPRLINPTGSISEGRTRPFAGADKPRSSHETADHFRADSPHGPPSSDVHSSRPVADDSRATRRGDGTLAWRMITNPAALSESVVSDVHSLHTISPISTTFATPPPSGMPHTHAVEFSSVPRPSRDAHAAGGNLPDHTPFSVGPDHIEILSHDGRSMRRPSSSLLRSTDAPPPYPSSRRALHRDFGGFPMPNVIFSRLLKRFFPKFERKLTRTMTIPRTRTIASQHGTVLAGVNAVPYITFEAVVGRNSAFKNLTREQMDELGGVEYRGLTALLWLVAGYHILLQLLAFVVIAPYMSIPRWSSDFRPPMLHREVSPVWFSLFQVVSSYTNTGMSLEDTSMVPFQTAYPMIVLMIILILAGNTAFPVFLRLMIWTITKVIPKHSRLNVTLHFLLDHPRRCFIYLFPSHQTWFLLTVLLVLNCTDWFFFLVLDIGNSAIKSIPVGVRVIIGLLQATAVRASGFGTVPLSVLAPAVKVLYVIMMYISVYPIAMSVRSTNVYEERSLGVFKEDDSIDETFNPSGNRVTVWGRYLASHMRKQLSFDMWWLALALFLVCIVERDNLINTNNLEWFTIFSILFELVSAYGTVGLSLGVPYANYSFSGAFRPLSKLILCAVMLRGRHRGLPVAIDRAVMLPSEFQESLDQDSPIRSHDTPNDSRDTFDRPEPQTDNLYLHETNSTRQRPHPFSRRHSDSSIHEMRLWNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFB1</accession>
    <name>A0A401GFB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0305960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611789.1">
        <property type="nucleotide sequence ID" value="XM_027755988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFB1"/>
    <dbReference type="STRING" id="139825.A0A401GFB1"/>
    <dbReference type="GeneID" id="38777793"/>
    <dbReference type="InParanoid" id="A0A401GFB1"/>
    <dbReference type="OrthoDB" id="3040543at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="41457" checksum="9903EBA72A9BEBDE" modified="2019-05-08" version="1">MQLIPAAAFSAIPVHRHIISNPFPTMTAPKPTELKLSQPEPFSGDMSKTKIFLQRVQTYVDINDEIYNSNKKKIAFAMSFMRGGTAEAWAETWYDDHTDNLGKLKDYGTFDAWVIDFNKAFQETDPMGSAMKDLESLHQTGEVQDYVNLFLVLMKKAKITEYPARLHYFKIGLSCRLLERIMNVNPLPTDMEGWYKKAVEIDNQTKSMQMYTKFQNSCPSRQQQKQGQQQRKGPVYTRDPNAMDIDRMSQEERDRHIKGGLCFECHQQGHHSHDCPKKKPKNPRNTSRMHKEIQVEEYEREPSTSKTEDVEEDTASVKRMTISDSNVSKLLQELRKMQKERNDWIKKLEGSDFGSDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFY6</accession>
    <name>A0A401GFY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0308320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612020.1">
        <property type="nucleotide sequence ID" value="XM_027756219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFY6"/>
    <dbReference type="GeneID" id="38778024"/>
    <dbReference type="InParanoid" id="A0A401GFY6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="147" mass="16231" checksum="3B636AD4CD1A3188" modified="2019-05-08" version="1">MRAGFVCCSCWDSYAWEIDGEDIADSAYKGFAGVRGVNSAKAARPATEQIDHNNEESLHPRAMVLRTAAAVGLWLLKGMELPCRSQPPHSQSAFHIFVTLCICFIITVPAVGRRFYTQRPHLPPIIIFHHCVTRENLVVTAPQIVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGA4</accession>
    <name>A0A401GGA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0308810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612068.1">
        <property type="nucleotide sequence ID" value="XM_027756267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGA4"/>
    <dbReference type="STRING" id="139825.A0A401GGA4"/>
    <dbReference type="GeneID" id="38778072"/>
    <dbReference type="InParanoid" id="A0A401GGA4"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019410873" evidence="1">
        <location>
            <begin position="22"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="64"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="434"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="891" mass="96396" checksum="224DE139019DA439" modified="2019-05-08" version="1">MLVHTPFPVLVIFMGWLIVSGHGSLCISPLVAGNSTPSQPFWLEDMVQRGTSAFNADPATYQVYRNVKDYGATGDGVTDDTAAVNYAISFGDRCGEGCGSATTSPAVVYFPQGTYLVSEPIIAYYYTVIVGDAKVPPTILAAPNFTGIAVIDADPYDAYGNWYTNQDNFYRSVRNFVIDLTQMPASASATGIHWQVSQATSLMNLVFDMSTEPENNHQGIYMEDGSGGFMGDMVFNGGKYGLWVGNQQFTVRNITVNGANTAVSVTLRPSTWSTPTDLSPQVYGLWSWGWTYQRININNCEIGFDLTIGTANGSAQGIGSEAIIDATVTNTPIFVQRSATSNHTLDGSLVLSNVQLDNVTTAVGVVGGEVLLAGGTLRIDAWAQGNVYAGSNPNGTYTQGYIDPLLKSPVVLDSTGKIFSKGHPQYADYSASQFMSVKSQGAAGDGHTDDTAVIQRVFDEYAGCYIIYFDAGTYIVTSTITIPAGTQVVGEAWSTIMGSGAYFQNMDDPQVVVRVGEPYSYGLAEITDMIFTARGPAAGAIVVEWNVHDPAGQQGAAGAWDTHIILGGKNGSDLQAYNCAAVYYDVNTECYAAFLALHLTPGSSAYLEGLWVWLADHDLDWPGNAQVSLYSGRGILSESLGPAWLIGTASEHNVMYQYSLVGAQNHYIGTMQTETPYFQPDPAPPAPFTPNPAYLDPEAWFGAALALQISSAENILVYGAGFYSFFQNYTQTCEATFSCQMQIVNVDTLTSVGIYGLQTVDSTLSRRLAILALSNTIRGVRWARDKSRLNNLLTPDGMPGQEEATDCQSSEIRRDGQRGKSNCIYPGNQNSFRLPRLLYSRELFEHNASCTLLIYESLLASWVRRVLSPTTRINILFGPLAFPLVDTDRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGU5</accession>
    <name>A0A401GGU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyporopepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0311450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612329.1">
        <property type="nucleotide sequence ID" value="XM_027756528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGU5"/>
    <dbReference type="STRING" id="139825.A0A401GGU5"/>
    <dbReference type="GeneID" id="38778333"/>
    <dbReference type="InParanoid" id="A0A401GGU5"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019487303" evidence="5">
        <location>
            <begin position="19"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="80"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="405" mass="42114" checksum="1E6789BB1093C085" modified="2019-05-08" version="1">MAFGSLLSTLVLALAVAASPVAIPPNSFVSLPLARRFNATGTVNLLQRDQARAAALKANGRARLQDRSGSVAATNDAITYTVQVDIGTPGTSYSLLIDTGSSNTWVGAGKSFVSSPSTVNTGESVTVTYGSGSFSGTEYEDTVSLGNGLTIRNQSFGVASQTGGFYGVDGVIGIGPVDLTKGTVGYSDAEIPTVTDNLYSQGVISEHLVAVSFEPTTSEGVTNGELTFGGTDSSKYTGSIAYTSLTTTSPASYYWGIDESIAYGSETILNNTAGIVDTGTTLILIASDAYSKYQSATGAVEDEGTGLLRITSSQYSNLKTLNFNIGSETYGLTANAQIWPRSLNTNIGGSPSDIYLIVNDIGSPSGEGLDFINGYTFLERFYSVFDTGNSRVGFATTSYTNATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGW8</accession>
    <name>A0A401GGW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0311030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612288.1">
        <property type="nucleotide sequence ID" value="XM_027756487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGW8"/>
    <dbReference type="GeneID" id="38778292"/>
    <dbReference type="InParanoid" id="A0A401GGW8"/>
    <dbReference type="OrthoDB" id="112668at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="82" mass="9237" checksum="AA5F43674832A737" modified="2019-05-08" version="1">MAESFHWRMQLNNYLQSNGGVHLLTWEVYQVGPLHAPSWTAMAYIRGVEYGRCTGYSQGAVKEEAARQTLVALFADRGIVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHF2</accession>
    <name>A0A401GHF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0313390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612523.1">
        <property type="nucleotide sequence ID" value="XM_027756722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHF2"/>
    <dbReference type="GeneID" id="38778527"/>
    <dbReference type="InParanoid" id="A0A401GHF2"/>
    <dbReference type="OrthoDB" id="2741479at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19816" checksum="36B682484F92C805" modified="2019-05-08" version="1">MVKELIPDDDLQTHVSFYHSHVLVANLYCSDKDENELWHRACWLSGLGLTRHQKPDEVSWKAIAFNLIQKDGSCTNRECGTELLRANARRMVAAIEEKQLIEEEQDQFFDGEQSVDGEQSIEEEPACYHTLYCTPGPIHNRTCSSLMPTTSFWNTGAIQSLDSYALKSKNTPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ20</accession>
    <name>A0A401GJ20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0405570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613090.1">
        <property type="nucleotide sequence ID" value="XM_027757289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ20"/>
    <dbReference type="GeneID" id="38779094"/>
    <dbReference type="InParanoid" id="A0A401GJ20"/>
    <dbReference type="OrthoDB" id="3237202at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="94"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="381" mass="43012" checksum="92070930A33356C0" modified="2019-05-08" version="1">MVQLVEQPQWQRKKDKKTISSSALSQSRDRRVAFTIWSIPLLRTRGGSNITPQCEGHTLHEQHSQPHEPSLHTGTHNFAEYLVKARRARFHREVIEYEATIDAKSNRVTCWIPSQEGKNFVVNWRDHGSQVETATYINLDGFVVPGQFLFGEGDAMRSAVRVGEDMERPFVFQRIEEPETLQLHDPGVPRGKDIGTILVRIKRIKRKELRPSNAPQTPPAMTQGRRGIGEPCIGYGEERAARQRFETTWKIEPFDKRNPGAYVVFAFRYRSRGFLVSQDIMSPDDSEFRTPPTPLLASSPPTPVSMSPTAATPSSTPSPSRPRMSMEGRSISLGNSHSFGTVSSNNSSPSNMSPRMYQLSIEDTETVPWMNSLQHNPNGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKF3</accession>
    <name>A0A401GKF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613542.1">
        <property type="nucleotide sequence ID" value="XM_027757741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKF3"/>
    <dbReference type="STRING" id="139825.A0A401GKF3"/>
    <dbReference type="GeneID" id="38779546"/>
    <dbReference type="InParanoid" id="A0A401GKF3"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="132" mass="14218" checksum="3C258D0FB2B42BA1" modified="2019-05-08" version="1">MSQPVLASFDPLATHPFTNNSGLLPKPAAPSQFPLPISSSLRTAATSPSRRDSTAPPLLAPQPTRASPRSKAAKSAAGSTHRPIFVPFRPERSSPELDDILLRKKFSDIFANKQSWSIDQAVVPLPSHSAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKJ7</accession>
    <name>A0A401GKJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0410650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613593.1">
        <property type="nucleotide sequence ID" value="XM_027757792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKJ7"/>
    <dbReference type="STRING" id="139825.A0A401GKJ7"/>
    <dbReference type="GeneID" id="38779597"/>
    <dbReference type="InParanoid" id="A0A401GKJ7"/>
    <dbReference type="OrthoDB" id="2737573at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="209" mass="24705" checksum="22F0454B57460ED6" modified="2019-05-08" version="1">MKHKWTTDAIQQWTNRRDEYRQRKNLPPLTDLRDSLDPKDQQAYRTALTTERTILLKRLDAHATETMSWPYGAPFSGVLYLPLNFRQTHGTTKLGFRQGDDLNRIVFEFYNEEVQKNYPGPNFIAQDGLRPKRYEYLGPMPFVVGYQLSEAAGEASIEWWDRYLQLKWINDGTWRNEVDFDDNVQGWVSKSRGDYSRNLDMFEYTGLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL96</accession>
    <name>A0A401GL96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0413230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613849.1">
        <property type="nucleotide sequence ID" value="XM_027758048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL96"/>
    <dbReference type="GeneID" id="38779853"/>
    <dbReference type="InParanoid" id="A0A401GL96"/>
    <dbReference type="OrthoDB" id="2757515at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="162"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="401"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="740" mass="83839" checksum="52A923F0C1C06920" modified="2019-05-08" version="1">MGHYTNKFEVRPTAHVPVVFKKTTFFQATMNTTFVRMSLDDFTRFFLPMDLAASHRPRTLEDVFLPIPYTGGASVGFYAALERCIDKTNLCPGYALEPIENDSACDNASQSNICAALVYEDDFAAADESLGWALHRLSFLRRPHCTRDDPFENLDNDGKVRIPRNTGRRTDEARRTATLQHLTTQARIMFSHQHRCFAFSVLILGEHARLVRWDRAGAVVTDKFEYKHTPHLASFLHTFARMSPEQQGADVTAELVDFDSDDFRLMLEVANHDVNGSSYARDLFHESIQEPDWACWKLRVPSGDGSEESREFLVGKPLFLANELRGRATRGYVAFDCLGERFVFLKDVWRVSFPELQQEGDVLQTLQKAGVKHIPTFICHGDIDGQRSLTQEHATSDRLASAYVHYRLAVEEVCRPLGHHRDGQELVGIVADCVEAHGQAVERAGLMHCDISAENILIFEKPVLQGVSEWRGILCDWELSRPVHDGPNSMKEAVRFQGATGTQAYMSVHSLDHPDSPITVADELESFFHVLFNVALNSTENNIPNLEEFLTQYFHSCPADGRCGSVKRTAMIDGRFMHQDVPIMFADSAEASQWPLNVLLPILAAWFSARYALEHFKDIMESNRDSNKMAKKGGIKLRRVPPLLRYLDFTVAITWCRDRVAQLKTHDTMRQLLQIFLPGVTQPADDKSSTVDYIGRNAQQDSSVSTTNRKRSLEEEPVDLPLAKRAKYLPARTHHLKNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLL3</accession>
    <name>A0A401GLL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0501230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613990.1">
        <property type="nucleotide sequence ID" value="XM_027758189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLL3"/>
    <dbReference type="GeneID" id="38779994"/>
    <dbReference type="InParanoid" id="A0A401GLL3"/>
    <dbReference type="OrthoDB" id="14603at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE83077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="144" mass="15584" checksum="417D5B74629C4BA8" modified="2019-05-08" version="1">METPSTPRAPSSSSSSPPPQHVVFQPETTGSYWSDVKEAVKRISFWDDLQKIGEIPCARSSLLSGIASGTGIGVIRGMSAGPFVACNWAVGTFALISLGTWTICRRSLEEERRRIQQVVEQLPKRFAKAQEDSTSSPEGPKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLZ6</accession>
    <name>A0A401GLZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0502550</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614121.1">
        <property type="nucleotide sequence ID" value="XM_027758320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLZ6"/>
    <dbReference type="FunCoup" id="A0A401GLZ6">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLZ6"/>
    <dbReference type="GeneID" id="38780125"/>
    <dbReference type="InParanoid" id="A0A401GLZ6"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000161">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1030.10:FF:000002">
        <property type="entry name" value="cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="15">
        <location>
            <begin position="449"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="798" mass="91559" checksum="B280EC1E211BC295" modified="2019-05-08" version="1">MAACAPTARSPVSYLALLPPPSTTPSNTRSAMASTSAAGGSYPMPPPTADLATTWAYLEEGVDHIMTKLQTGVSYSKYMSLYTVSYNYCTSSKMHGNGDQPGLGHRTGANLMGSDLYNNLIRYFVNHLKTLRTQSDAVQEEALLRYYAGEWDRYTTGANYINRLFTYLNRHWVKRERDEGRKGVYPVYTLALVQWKSNFFLHVQSKHQKLAGAILRLIERQRNGETIDQGLVKKVVDSFVSLGLDEGDINKVSFEVYKEHFEAPFIEATEKYYRQESEAFLAENSVADYLKKAEERLREEEDRVERYLNTNTRKSLISKCEHVLIREHSELMWENFQSLLDFDKDEDLQRMYALLARIPEGLEPLRKRFEDHVKRAGLSAVSKLVGEDGSGADTLDPKAYVDALLEVHQKNSETVTRSFRGEAGFVASLDKACREFVNRNGATGTSTTKSPELLAKHADALLRKSNKMSEEENLEGALNKVMILFKYIDDKDVFQQYYTTKLSKRLIHGVSASDEAEASMISKLKEACGFEYTNKLQRMFTDMSLSKDLTDQFKERMQQNHDDMDITFSIMVLGTNFWPLTAPHNQFVIPADILPTYERFQKYYQQKHSGRKLTWLWNYSKNELRTNYLNQKYILMTSSWQMAVLLQYNSNDTLSLDELVSATSINKDILKQVLAVLVKAKILINEETDQYDLNPNFKSKKIRINLNTPIKAEQKAESADVQKMVDEDRKYVIQATIVRIMKARKTMKNQPLIQEVISQISQRFSPKIPDIKKAIEHLLEKEYIERVEGTRDTFAYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMI2</accession>
    <name>A0A401GMI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0504500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614315.1">
        <property type="nucleotide sequence ID" value="XM_027758514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMI2"/>
    <dbReference type="FunCoup" id="A0A401GMI2">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMI2"/>
    <dbReference type="GeneID" id="38780319"/>
    <dbReference type="InParanoid" id="A0A401GMI2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="55" mass="6232" checksum="B87F6BA9DAD00E61" modified="2019-05-08" version="1">MGKVHGSLARAGKVKSQTPKVDKQEKKKTPKGRAKKRILYNRRHVDYVAEQSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GML7</accession>
    <name>A0A401GML7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0505050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614369.1">
        <property type="nucleotide sequence ID" value="XM_027758568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GML7"/>
    <dbReference type="STRING" id="139825.A0A401GML7"/>
    <dbReference type="GeneID" id="38780373"/>
    <dbReference type="InParanoid" id="A0A401GML7"/>
    <dbReference type="OrthoDB" id="3022201at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019341629" evidence="1">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="268" mass="28670" checksum="CBB63D6F7AD42F0E" modified="2019-05-08" version="1">MLSTVAISALLVAASAAPSLALPVVPTSGREAVNWKDVGGGIVKTPFHFEHPYVARADGEALRIGRPFEVNKLPVHFPTFVSSHAARDSQFMARAEPTDREASYVNRVARDTGSAILNFLREEDPIMARAFEDELMARAELAGSEGVTDTAFARRSGKATTPPTSPTTAIPQAVSISWTGPANAEVAAMHAADFGGEDPKKWHEDKVHAFVSANTASLPGVTKARIRKAAHTGGTDPNEKEHITVNFLARNKIINSPQGGAWHVYTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMY1</accession>
    <name>A0A401GMY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0506070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614465.1">
        <property type="nucleotide sequence ID" value="XM_027758664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMY1"/>
    <dbReference type="STRING" id="139825.A0A401GMY1"/>
    <dbReference type="GeneID" id="38780469"/>
    <dbReference type="InParanoid" id="A0A401GMY1"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="308" mass="33842" checksum="61CEABC6F5E048AE" modified="2019-05-08" version="1">MPKLIAVTGATGNQGGSVARLLLKYPEQYKVRALTRDPSSSAATALAALGAEVVQADLVLPETIRPALEGCWGVFGVTNFYDPKIKDDPGSEEQQGRNLVDAALAAGVACFVWSTLPSSRKISGGRLVSRIYEGKCQVDEYIRETGLPATFLYTGNFYENMVYRAHMQYDPEADVVEFHQPVVKEDTKLAMLYVEKDLAGVTKAVLDQYEARPELHHEYLYVSNARVSPREIVAAVTKVTGKRAAYVTLATTGVPDRDIMFRLYNEMGMYGGKEIPDENVLALGVELHSVEDFIRERLAPHLGLPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN05</accession>
    <name>A0A401GN05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0506510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614509.1">
        <property type="nucleotide sequence ID" value="XM_027758708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN05"/>
    <dbReference type="STRING" id="139825.A0A401GN05"/>
    <dbReference type="GeneID" id="38780513"/>
    <dbReference type="InParanoid" id="A0A401GN05"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="56"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="204" mass="22836" checksum="439D8A52F0FC24C3" modified="2019-05-08" version="1">MTVLMTSSNKKDMARYHRSPRTQEQFQRLDRLLAHTFVRNLIRQRVLSFQQSSRSSSEKVYTPRMDMFDDADDPFVSVVLELPGLKQEDISVRTENNHLVVQGERRFPVLLQHNVGGDNSALARTSSEAVAPTHYKVQELKYGKYKREIPLPSGIQAGDIQASLSDGMLMLSWPRCASATLEYPEPNAAEAIASEPATAAATVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN22</accession>
    <name>A0A401GN22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0506240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614482.1">
        <property type="nucleotide sequence ID" value="XM_027758681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN22"/>
    <dbReference type="FunCoup" id="A0A401GN22">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GN22"/>
    <dbReference type="GeneID" id="38780486"/>
    <dbReference type="InParanoid" id="A0A401GN22"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="871"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="906"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="974"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="974"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="985"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE83569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115055" checksum="6BE87044CF1587D5" modified="2019-05-08" version="1">MGLFSRRRRSPPTDEEAAAANGSAVGANEKPNPYEGGDEYDVLLHYAHDEAAKLSHGEDEEEDKDEGKMVRLWYAPWKKVKKGGKQERKVPQEWLQTDMTRGLASSEVDQHRQGFGYNELQSREENQILKFISYFRGPILYVMEIAVILSAGLRDWIDFGVIIAILFLNAGVGWYQEKQAGDIVAQLKAGIAMRATVVRDGREQEIEARDLVVGDIVVLEEGGTIPADAKILADYNDKTGQRSKPALARRKSTSSNMSSGSTASRDKGPSLCSVDQSAITGESLAVDKYIGDTAYYTCGVKRGKLYGLVLCPASQSFVGRTAKLVMDSNERGHFQIVLGGIGSVLLFLVVGFIFITWIGGFFRGIGIAEPSENNLLVYALIFFIIGVPVGLPCVTTTTMAVGAAYLARRKAIVQKLTAIESLAGVDMLCSDKTGTLTANKLSLNDPYIAPGVDPDWFMTVAVLASSHNVKSLDPIDKVTIIGLKDFPKAQENLRAGWTTHKFTPFDPVSKRITAEVERDGRRFTCAKGAPNAILRLQQFPQETVDQYRAQAQEFAQRGFRSLGVAIKESDQPWQLLGMLCMFDPPRPDTAATIREAIDLGVHIKMLTGDAVAIAIETCKQLSLGTNVYDSERLIGGSMTGSEVRDFVEAADGFAEVYPEHKYQVVQMLQQRGHLTAMTGDGVNDAPSLKKADCGIAVEGASDAARSAADVVFLDEGLSTIITSIKVARQIFHRMKSYIVYRIALCIHLEVYLMLSMLILNETIRVDLIVFLAIFADVATIAIAYDNAPFDRKPVDWQLPKVWIVSTVMGLVLAGGTWIIRGTLFLTDKGIVQNFGSVQEILFLEVALTESWVIMITRMSQGPDSGPFVWPSWQLVGAVLGVDVLATLFTLFGWISGPAPHGGWTDIVTVIKIWLFAFGVTVVVGFVYIILNKFRWLDNIGRRVRSKKDAKFENFITEMQRLTLVHERDSRGESIYRISGSSSSTNEKKDEKKDEKKNGRPKNEQRRPSADSQSQQTQVGDAKSEKSAQEGRRPALQDQPSRTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNK3</accession>
    <name>A0A401GNK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein rds1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0503720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614237.1">
        <property type="nucleotide sequence ID" value="XM_027758436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNK3"/>
    <dbReference type="STRING" id="139825.A0A401GNK3"/>
    <dbReference type="GeneID" id="38780241"/>
    <dbReference type="InParanoid" id="A0A401GNK3"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019557301" description="Protein rds1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="31398" checksum="FF212C4B29D6EF04" modified="2019-05-08" version="1">MFARSALLAVLSSAALVAAAPAAAITDTSILNYALTLEFIESAFYEQGLDQFSDIDFVLAGFAPWVRGRFTQIHAHELSHAEFLTSQLQALGVTPVQACTYSFPYTDVQSWVTLSMTLEGVGSAAYMGAANFISDKNVLIASQSIAQVEARHNGWVSSAVNQLQPWDGPYETPLYFSQVFSLAMGFVVECPATNPALPVSVFPALSISNAAPASGDTITLTYTSNAPNNAGQTYLAWYSGLTTIFTPIVNGSTTVPDGLLGTVYAGVVANQSAQTGDATIITGLAVFSFPFGAFAAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNN4</accession>
    <name>A0A401GNN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0508850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614741.1">
        <property type="nucleotide sequence ID" value="XM_027758940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNN4"/>
    <dbReference type="GeneID" id="38780745"/>
    <dbReference type="InParanoid" id="A0A401GNN4"/>
    <dbReference type="OrthoDB" id="3320394at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="466" mass="51915" checksum="292103BEFE4DE725" modified="2019-05-08" version="1">MARHGRKSGHLTATRKKPGRPPEQPAELGPDPKLTHLLLKLPPHLPPSHPPVQSLIENYISPSSSSSNEDVLYGAQVTQDDNDDGVVHNSETDGDDITVTEPASQSTQGDHGKVITPLHAQPVEVEYMVPKHDGKAMKRVPLSSAMTWDIVRERLRIVMGYDNVDDMALSYRLSKDAKSVRKSLEDDNDYQGIVQSMQSHRRNTRPQQVIILDDSVNDSEQELSQPKGSHKKAPGMKAAAVAHAYATVEHQSQIDEVVEELKRQNPKCSEHAMSCWLGHPSGEHVQLTEMRFAAWATDIVKQLSLPEMERTVTYTHPPNNRMFDVPPSFRHQHAPSVSKAPSTSMPVPPIIINMPEMSGSHKHLIVSPSSSDPVNPADAPWPSLTDFLLHAVTVDRHSRNYPAYEPGLRQADLLGPDDIEKCTEEELKKHCDIPIGAGQFLIHEAKLVCKQIRQQAQIPQKCFRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNV5</accession>
    <name>A0A401GNV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0509640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614818.1">
        <property type="nucleotide sequence ID" value="XM_027759017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNV5"/>
    <dbReference type="STRING" id="139825.A0A401GNV5"/>
    <dbReference type="GeneID" id="38780822"/>
    <dbReference type="InParanoid" id="A0A401GNV5"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="660" mass="75462" checksum="1FC085E816B3622B" modified="2019-05-08" version="1">MPLKKAKKSEATPSNAAREVAAAPQSARRALRGRRGGLKDMPNMPLDIVLEIISHLNPRDLLNLARTSKAFRALLMTRTSAHLWKAARKNVDGLPDCPPYLSEPEYANLAFSPHCHSCLKSNIQNVIWEFNVRYCNDCKKENTVESPYGLPTGLMSKITSSVNVLNHISGRRYLYLFHVPQIDAFVKSWRAVASDEGEKKLIKEQAERVNQIKEYSRLCNEWTKLRVKSRASELDDVRRARLESIVSRLRDLGWGEELDFLEPKQYSPLSNHAHARQAKPLTDRGWQKICDEMVSYMEKLKTQRLAEEHRERLHSRLALLSDLIDNYYAGIPRTPASEYLPHLVDFAMMSEFRALVDALDSVNITPDDFLALRPQIPNLVEKWQNNAKAELTLLLAEELGLTDIPDDTNIFDLAVAWFQCTKCRKVLRYPNIIAHGCMRQYYHGFYHPDAAHEYQALVYGEARTAAWSTASISCSRPVQRAYMLVKACGKDPSSTTARAMDELDARFWWKNPSALPSRSVVSWRLAMKPKWTRKHVGGVSERQWEVVNGNVAEKVKVVEAKSQITRRFKHELRRHWCCSLCTEIGGRKCSLPQVKEHVRNLHSIDDPTVENGRIYLHPDSKPLLPKSIMALKSTGNSEYELSREAMNLLREGRACLCDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPF0</accession>
    <name>A0A401GPF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615010.1">
        <property type="nucleotide sequence ID" value="XM_027759209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPF0"/>
    <dbReference type="GeneID" id="38781014"/>
    <dbReference type="InParanoid" id="A0A401GPF0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="6810" checksum="7AB746EC0371C9F0" modified="2019-05-08" version="1">MNVVGAAAQPFADATRHPDNVNGRSAAGGSRKLPLLWAPDLGKVRAESSGVHLSNFVPDGSAPGGAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPL3</accession>
    <name>A0A401GPL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyporopepsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0600670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615002.1">
        <property type="nucleotide sequence ID" value="XM_027759201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPL3"/>
    <dbReference type="STRING" id="139825.A0A401GPL3"/>
    <dbReference type="GeneID" id="38781006"/>
    <dbReference type="InParanoid" id="A0A401GPL3"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019117582" evidence="2">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="51"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="372" mass="39390" checksum="3E39AA53DDC11D04" modified="2019-05-08" version="1">MPYQKRPMFKMLGMLLLISVVQAATLFKVPLTTSLIAGDPAVPDRNAAFMTTVSLQAGNFQTWSNVLVDTGSCLVWVGGTDQQQYIPGSHSVPMNESFGAGYGSAGASGTAYLDRVTLGEATVNRQVIGAANYSYMSSFEPFDGILGLGVPGCNGGEVSGYSTTPTFVEGLVAEGSIESPVFGIYIPPLSEEGISEGTGDITFGGIDESRISGEIVWIPQIPPYTNRYVLNISSVSYGSTVVQSEPVATYTDTGNVALGLPFDAFFAIYQTVPGAGLDITSDLQGSITFSLNTSADALLPVTISFQGVNSSLDISIPSSKYLVPKSLYPTLNMTDDVLHSWILPGVLGQNFLQNVYSAYDQENHLIGFANLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ20</accession>
    <name>A0A401GQ20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0602940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615229.1">
        <property type="nucleotide sequence ID" value="XM_027759428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ20"/>
    <dbReference type="GeneID" id="38781233"/>
    <dbReference type="InParanoid" id="A0A401GQ20"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="163" mass="17599" checksum="6AB655144393988F" modified="2019-05-08" version="1">MATASGACHAAESSSVEDAGPVRGRVPYVDVPPMPRTHCDALIRELQKDLLQDLEACITSLEEEQEHLKQDNNKVTALLNKLRGAPTSAADADDLATHVNGFDTALYYIRQKQDRMAADFVTMANALRGAGVTVPTLYAEQPDSDADNEVPAGSEENDDDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQD5</accession>
    <name>A0A401GQD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein transport protein Sec61 subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0604150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615349.1">
        <property type="nucleotide sequence ID" value="XM_027759548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQD5"/>
    <dbReference type="FunCoup" id="A0A401GQD5">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQD5"/>
    <dbReference type="GeneID" id="38781353"/>
    <dbReference type="InParanoid" id="A0A401GQD5"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="10305" checksum="6DFAACEC53DE10D9" modified="2019-05-08" version="1">MSDSDVSRPAATGRSAGSGVAKPPGAQIRRRATSTPVAKPNSTRAAGAGGSSNTMLKLYTDDSPGLRVDPFIVLVLSLSFIASIFFLHISAKIIRAFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQS2</accession>
    <name>A0A401GQS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 52E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0605560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615490.1">
        <property type="nucleotide sequence ID" value="XM_027759689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQS2"/>
    <dbReference type="STRING" id="139825.A0A401GQS2"/>
    <dbReference type="GeneID" id="38781494"/>
    <dbReference type="InParanoid" id="A0A401GQS2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE84577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="593" mass="68240" checksum="29EBE50D80F95EE7" modified="2019-05-08" version="1">MIRLPPGVSFLVRGAVLIAAPPAFVIYLNNFLSRHFQHTLPTWIAVLAAVLSTPIIIVLNNWLRSWRIRRAAVRLGAVLPPRWDGKWIGNIDLLRKSMDAFLNGYPGDNFVDKIDELGPTFQINILGATEYSTCDPDVIKLVLATDFNNYVKGEFFYNMMHSVLGTGVFNSDGERWKFHRSMTRPFFSKDRISHFELFDRHTEEAIMKMKERLHEGRGIDFQDLIARFTLDSATEFLFGHCVHSMESPLPYPHNVITSHTVAKSQSSEFAVAFGEALQVLSIRARSGWTWGLFEVFQNKTDKFMKVVDLFLDPILKDALSKKEMRMKEASKQEEKLDEDNETMLDHMTRFTSDPVILHDEVLNILLAGRDTTAASLTFVVYFLGMYPRVLERLRSEILEKVGPISRPTYQDIREMKYLRAVINETLRLYPVVPFNVRSSLKESTLPNRDPTGKPFYIPPNTGISYSVLQMHRRTEYWGPDALQFDPDRFLDDRVAKYLTPNPFIFLPFNAGPRICLGQQFAYNEMSFFLIRLLQNFSSITLDPDSHEPGTLPPKEWAGARGRKGIERFWPKVHLTMYSYGGLWVKMTEANNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQT1</accession>
    <name>A0A401GQT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0605660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615500.1">
        <property type="nucleotide sequence ID" value="XM_027759699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQT1"/>
    <dbReference type="GeneID" id="38781504"/>
    <dbReference type="InParanoid" id="A0A401GQT1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="67" mass="7517" checksum="59E7D1C6BDDEF284" modified="2019-05-08" version="1">MHTLLRQQDLDNWRDNYAGFETVKARPPLAGAASAAGLMSECDVEECGREALRQCYEVRVEIPAVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR03</accession>
    <name>A0A401GR03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615555.1">
        <property type="nucleotide sequence ID" value="XM_027759754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR03"/>
    <dbReference type="GeneID" id="38781559"/>
    <dbReference type="InParanoid" id="A0A401GR03"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="175"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="38941" checksum="512D7A253AF671A7" modified="2019-05-08" version="1">MPGKPLPPNPYSGPEEAAYNTCRHLERLLDWSEVVSDEVRTSKRTPQLCGRLLGYMMLEAPTPEGRLNVAREIQTCTSASDTQDRLAALAQFYEHHFIRVFKSAKGATPTVSTHPSRPSFNMTAEQINQLLEEAPQDHRAAKLLIFHLTGRYDAATAISRYPEDETFIAPAPIAPTELAHIIAESTNANIQEGSTKRSYAASAWAVLDRFGKVNVVDNELNGQGIHRLPNVMTMSVDVHIFFDTLQIWFEEIGTDRYRLCARWDSILTSLGVDLNNPVIQLTTTNASLPLPNSHLLRLHATCAKVAHLSGAGEYIDAIFRDMEELKVLASDGGSAHVLQDALLHSGRQVAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRB8</accession>
    <name>A0A401GRB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615679.1">
        <property type="nucleotide sequence ID" value="XM_027759878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRB8"/>
    <dbReference type="STRING" id="139825.A0A401GRB8"/>
    <dbReference type="GeneID" id="38781683"/>
    <dbReference type="InParanoid" id="A0A401GRB8"/>
    <dbReference type="OrthoDB" id="3174539at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="58493" checksum="96204D2AC1E65E44" modified="2019-05-08" version="1">MLTLQNFVSRVRHGGSKELQLSPMARCLQIDELVRPIIYMIYETSGKREVARIARTCRAICAPSLDIIWEDMDKLLPLFKLLPPYSWELVDAGRGKTYSRDLSKLAWRAISSRWARWHHKAASEKPPTSTQTFRWLGFPSNVEWSSREIDLKPFQDYASRIKTFTWKSGTQNNLTVSTIQSVFRELGSTAVLLPKLRVLHWKMPRDDLLPLATRLPGENLEKLVLYHNATPVVVKTLKELRLSSRLCNLESLQIGVPMSKELGDEMAQVLQGTKSLHRLYYVFSSIPLLVVQALAERQTLTHAEFGVVAKDLLELQALAIGNAFSNLITLTLRLDTLAEGTLALLGNISSPRLKALSVEVEDCPTADTVRHHLECLVKTRFIRELVELKWVMGQFACSRDQMHTPQKRRELLITPCTLEPLLHMGRLKHLVVKGRHLALDMPFLECLSVAVPDIIELHFKHFSLYARHGETACTFFKLSDVQFLRDRCHHLRVVGLNLVDYEGWREVRVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRT6</accession>
    <name>A0A401GRT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0701080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615839.1">
        <property type="nucleotide sequence ID" value="XM_027760038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRT6"/>
    <dbReference type="FunCoup" id="A0A401GRT6">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRT6"/>
    <dbReference type="GeneID" id="38781843"/>
    <dbReference type="InParanoid" id="A0A401GRT6"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="447"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="729"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE84926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1261" mass="138244" checksum="980CF41AEDF4919D" modified="2019-05-08" version="1">MDRTRQRYNAKARQSTAGSHKKKGRRKDIEALPSQHSDPNAPIIDLKTLEQKEDDRKERLRKELLAQSDSKASSKKKKRLEKYIEKKLKQEERVVLFEKLSKSQAQLSIALQLQSSSTLGTGKPSTHKQLLDTQEDRDVRRAMERQTGKTGHQQSSVLGVEESVSDEDGISVEVDREDDGSLPAAQSGDGLSKSDPIVVVDSGSITSIVPTAQPAPTPSVVGSALHRNPDGSVVAPRIVKRKPKSSKIHFSSWTVQRSAMTSHDSDAESDSSFNSSDSAYDDDSADEGASKPTQDEEREEDPDVSSESGSALGKGERGSPPPEDALPTNKRKRGGFKEWAMKQLSAAKGYVAPVEPDTPSDPPEQEIAPPPKKRKVETSEPREVRGPLGEDLQLPSTTLARHLQETAGKPASVSITDRRKVIGVHRPPEVQEARLLLPMVAEEQPIMEAILFHNVVIICGETGSGKTTQVPQFLFEAGYGSPGGENPGMIGITQPRRVAAISMASRVAHELGFNSSRVSYQIRYDATVSPSTSIKFMTDGVLLRELATDFLLKKYSVIIVDEAHERSMNTDILIGVLSRVIKLREEMWRDGKNNIKPLRLIIMSATLRVSDFAENKTLFSSPPPIINVPARQHLVTIHFSRRTSSDYVTEAIRKASKIHARLPPGGILIFLTGQNEISGVCRQLEAKYGKKTLDGRRQMRKATQQRLGNQTQDEPENVHSFQVTPSQADVEAEDLDLGNVQQDGDDLAFDIDGDVDGVNADDEALDSDDASAVDQELGIHVDESDTPMHVVPLYALLSSEKQMQVFQPPPAGTRLVVVSTNVAETSLTIPGIRYVVDCGRAKERRHDVANGIQAFRVSWISKASAAQRAGRAGRTGPGHCYRLYSSALYEHYFDQFSQPEILRVPIEGVVLQMKSMHIDAVVNFPFPTPPDRLHLRKAETVLTHLGALKAASGSDSFGGDITDIGKAMSLFPLSPRYSRMLVSGRQHGCLPYVIEVVSALSVGDPFLREETLGDDGEKSEEEHEEVSHLTSAAVRAAETRKIRRRAFFQSQQTHASLGNFTSDIFRTLSVVGAYEYAGGGHAFCSEQFVRPKAMEEIHNLRTQISNIVQANFPDLETGFVADLRPPSTLQLKVLRQLITAGFIDQIAVRKDVVEAVAASGAKYTTSKGVAYRALGISEDVFIHPSSVLASAPPPDYIVFLEVVRTSRIWLKGLTVVNAAWLSSLGRSLCTYSKPVKAKDGQSMVIPHFGPGGWELPAIEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRY0</accession>
    <name>A0A401GRY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0701770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615905.1">
        <property type="nucleotide sequence ID" value="XM_027760104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRY0"/>
    <dbReference type="STRING" id="139825.A0A401GRY0"/>
    <dbReference type="GeneID" id="38781909"/>
    <dbReference type="InParanoid" id="A0A401GRY0"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="536" mass="59373" checksum="D08DBDD514FA4E72" modified="2019-05-08" version="1">MQPSKELEQLCKLGISEKTAKFALENKGGNVEQAADFALSGEADRAENALERTTSSTSLQMGYLKPPDNSRNTGSFTRMSLSSMMGGLSSLSLSRGSSDERGRSEKTEKDKANFRSSSFSGVAEDERSSSRGRTRSQSPFRLRRLSTRERETSPTVEALSQSDVESDAEVSQIRPRNAFSLSAHEDEESGEESSEESSEESWSDDDQLDPVTERNTERNSLIPADVGEHDVVDVPDPLGEGVNVVVPPEPYFPSTLNTGSRNPRRRKSTRTHDALPLVSSRPVFQRDRCTITLTHGDPARTLEETGRRPKRYVLASDLSDESRYALEWGIGTVLRDGDEMLIVTIIENDSKVDPPIPNPADRATKLRSQQERQALAYILVRQATSLLQRTHLQVTISCQAWHAKNARHMLLDVVDFVEPTMLIVGSRGLGNLKGILLGSTSHYLVQRCSVPVMVARRRLRRPPRRSAHLAPHRARVSLAQAAGVDRVAAKVDQDVAVMRDQMEREEKDDTINVPDIEEDPDTEVEGEHPLGTKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS21</accession>
    <name>A0A401GS21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0701410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615872.1">
        <property type="nucleotide sequence ID" value="XM_027760071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS21"/>
    <dbReference type="STRING" id="139825.A0A401GS21"/>
    <dbReference type="GeneID" id="38781876"/>
    <dbReference type="InParanoid" id="A0A401GS21"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="792" mass="88648" checksum="43C05FB843F5A630" modified="2019-05-08" version="1">MAAPPDFDDSQGVPRPYKRPRHDSAADDALHPYSFPTASSPLHPETDPASEAAAKKNRKKPLSCGECRRLKLKCDRVFPCQSCCKRGCAEICPEGSLTGGKGSRFILANTEQLHEKIKAMSERIRNLEDALQSMHAQYSPEVHPLLRPELLLIKRSPELFGIDRSGMPTTSASDNHTGDEDEQPAAGSSSAPTEIVTDCPYTYPMPAMPLRNDIPEDIARLSHAFPVSPSTDSEFDPSLRQRLREMLPPPMEAQRICSQAQQNAFWHYSPDASESFIPNLLHSVYNAPLQALLPHRLSLFLMILAIGTMVDLKEDQDRARHDAERYHQLARAAMCETMVIDDPSFDAINSLFFMVWYLLMFSYHKKSIEHAWGIMGLLAKLAQGLGLHRDGVRLKMIPEELDRRKTLLWNMMSVDVRLALMLRRPPSICIQHVDAKRPMYSLENDSPSTSITASYNAWRDIFTVQCMAPVLESVIATQPPPYIDILQLDWKIRDFVIPPILRMVDDDGFIPNHPAGLQQALTFSARETALLNLHRCYFLQALNAEEGFTMKHKYAPSVLATYTSVCNVVWTVCTCYKWEPDLSLRITMLWHNCLSAAVALCVLVSRSPSNSLTPHALVELDNIMKLFSEVKSRCPTVVKATPLLDTIIPRSRIAYMNWRNGLQGAGCFEDEICVIARRTGILANTGAGNELMFLDGDASPFEHAHPLLRRCFEQSTKEGLSALDPLLPPHNSLGPLQTTSTSQTFSTSAERTVHEHVAPVGMHRNDSPSSQAACNAGWIGAEFQDSSWMTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU09</accession>
    <name>A0A401GU09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspyridones efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0802340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616625.1">
        <property type="nucleotide sequence ID" value="XM_027760824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU09"/>
    <dbReference type="GeneID" id="38782629"/>
    <dbReference type="InParanoid" id="A0A401GU09"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="248"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="442" mass="47236" checksum="1DF097C5738F5A6A" modified="2019-05-08" version="1">MSDVVDSSETKSSTSTVVVTPPAREGPPPPPDGGLSAWSTIAGAWMIQFCTFGYVSAFGVYQDFYALDFLPLYSSSDISWIGGLQLFLMYAPGILVGRAFDAGYFHHLEIVGSLLYVFCMFMLSLTSRNQYYQIILAQGVGMGIGLGLTFLPSLSIVSHHFRRRRALAVGIVVSGASAGGIVFPIMLNRLFQDPHVGFAGGVRASGGLVGGLLLLANALVRTRAPPRRLGSRMGLSWRSFKVVLRDGAYMWSIAGAFFTSMGSYIPLFYLQLFASDHGVNARVTTYLLAILNAGSIVGRIIPPFLADKWGVYALLLPSVFASATLLFSIFGATTSAGAVIVGLLFGFASGAYISLIPSLLGVLCRDVSELGVRMGFAYTVVAIAMLVGNPIAGALLNADAVNVQRVWWHALVFAGLCTIVGFGFMCISGILFHRRKERASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV15</accession>
    <name>A0A401GV15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0805890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616978.1">
        <property type="nucleotide sequence ID" value="XM_027761177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV15"/>
    <dbReference type="STRING" id="139825.A0A401GV15"/>
    <dbReference type="GeneID" id="38782982"/>
    <dbReference type="InParanoid" id="A0A401GV15"/>
    <dbReference type="OrthoDB" id="2575061at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1081"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="120681" checksum="AB652C02DA1B0718" modified="2019-05-08" version="1">MSRQYDSSTPPEDYSQNSSPSRPSSRVESDQAEQQHCRPTPVSEQPSSSAQSPQRVSSSSEGYPSWLPKRPPPPAPRSTIQSSVVGMFSEPGPSNESYVVGRKPTPRSVRIVSLQGSTTQGVEDVKRQREPTDQSRAFSNPAHARVWSRATSAGMSPTLFSSGAFSHFPRPRFNSMALHLELLRSPSWKTRLWFFLFPVLVLAHIPLQTFFDFNAVYILILVAKHPNPVAPGVPGSGRNWALGAAAYIACWFVWIAVVFIVYELLYSFYRRWRVKRPLMFPIYLSSPAFNYVCMTSYTNFCFMYHIRSSAFSGEHANVRDGLAETAYYYAQNWPTVALLLPRAALSLALLLAFSSTQADYLALADAGISQRDGAFFRANGTLSGYARGVLIANAAWTAWRILVLFLSLIGLWIFSGHGCAGLCGPRYRWEEEDAEKTVTAFSGEDAADMDALPWSWKECTLLRIKDSYDFCMTLKPPRSSSGVAPKEGHAESPEASMPFEGMQQVFAAAGLPSGPQPARRPVLSDKLFESPVPMGAELVEEKRSQEAGEPEGGVAPPAAVVQSKEQLSADPSGPLMKLPYPFTGYGAQVSSQDVVPFPPSPEPEEGVEVPIEGDDEEDGEEEEEEEGEEDEEEEGEEEEEEEEEEEEEASEERRTSGSMSSLGRPVASRYPFQFRRPQRTSMSSASRMSPPSHSTPHSAHSRSTQTHSTQSRSTQSRSTQSRSTHHSRSTQSTGNRESTDSPLSLGSSNAPSPLASSFSGSVMPMPPRHPQVERRARARTVPAPGTPGSATPSSPGSPSPVVFPARPRARTRTGSAATETSTTFGPVPVPAVDTDNEGYHEESLMDVPEAEGSIEEAEQHDSVGLLSAGPSPRQSLINLRRGSSLSQRRANGSRSRSGTGSRSDSRSRTNSAHSHSESVRSRAQSLIHSIGAASRSSLDLVRSRTNSMQRLSDSPFDSAQSDAVLSSPENHTFGHPLREQWRREEAAQGIEDIAEVPAPLEETQPEPAAASGSDIGEGSQGLQTALSTFSSGAPSAPPSERSVHTERLGVPIIGHGQVDETSQPDISTANQSFVTAAPTVEGTTTDSSGQTPPSWGGTDIERQYAPGGMGRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVF6</accession>
    <name>A0A401GVF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0900870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617121.1">
        <property type="nucleotide sequence ID" value="XM_027761320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVF6"/>
    <dbReference type="GeneID" id="38783125"/>
    <dbReference type="InParanoid" id="A0A401GVF6"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019354629" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="36152" checksum="611B69C688BA680B" modified="2019-05-08" version="1">MARLTALFVAFSAVALHVNGLPLTKRVAQVISDSTTKWEAACDTAGGGSQCNVIAVNSFSTLLAAPGPCAQQNAADTMVSLAKQLNSNEMITLAQVFAQQPRNSPSSQAVPYCQQAPNNTELNGLYQCQFQSVNEQTFVGGLAVGSAGTIPFGLSAPVSPAGSCPANPSGTIPDGQQLVDITQNPGVGSSGSGSSNATANASAAASSAASASATVAAVSSSAPVSASAPASATAGSGSCVAPSVASSVVTPVASSSAAGMMASASATASASSGNSSSSSFQQANGQAAQALNAQFASLTANSTCNAGDNACISSGFAQCVNGQYVNLGCASGLQCFALPLVNKQGTSIACTTQADALARIQATGAQGGVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVL2</accession>
    <name>A0A401GVL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0900980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617132.1">
        <property type="nucleotide sequence ID" value="XM_027761331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVL2"/>
    <dbReference type="GeneID" id="38783136"/>
    <dbReference type="InParanoid" id="A0A401GVL2"/>
    <dbReference type="OrthoDB" id="2752228at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="272" mass="30907" checksum="67E579419B440A40" modified="2019-05-08" version="1">MRIFAHDRFIAGYHMGLSQADSEQDSYFDRVRGPYFSEGAGTGTRILETISYWTHHAWSTRSAQAWTRRVNQLILEIQHVSPHDIDIVVTPMSRGLNMNMWEKVSNSFSLVASCMVIARLATVRSKPLSVWFNCLMALSICGAAVTGSFRRYQYVTYPCTILDKSGTVLASANPSRAKLFMERDLKAEYIKTVKMLIKTSESMIEKLAVLRSHHESHELEGHGVLDAVDTFIQTLKRNIEEMKGRVIAMERKIEILDAEIEAASRTTKEREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVP2</accession>
    <name>A0A401GVP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein arginine N-methyltransferase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0901310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617165.1">
        <property type="nucleotide sequence ID" value="XM_027761364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVP2"/>
    <dbReference type="STRING" id="139825.A0A401GVP2"/>
    <dbReference type="GeneID" id="38783169"/>
    <dbReference type="InParanoid" id="A0A401GVP2"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="400" mass="45785" checksum="AC51DB1CF5E42810" modified="2019-05-08" version="1">MLILEEGPEDETGMPTIHMRPGSNLFWAATGPIELIEHLVLELGVPVTVTDPMMGYSPLHFAAEMGKEENVRWFLDHGAPWNMANHYSVTPGELALEDGFPRCYEIIFEGGVRSEYEFWRLRDKSSARGEFGQHLKGNMRGQAYYVNNYEYLSTPVSFLNPRPEIPDDFAMVVDGMTGVMMEWERPLMKETARLLCEDMGKGKNILNVGFGLGIIDSYFQSYEPGNHTIIEAHPRCLKYMRENGWYDKPNVRILAGSWDKFIGPDASFEGLGTFDVIYFDTFQEGYPGHLRFLRCVPELLSGPSALFSFFHGHCRRWKMGYEVYAEVARWHANDYGISTTWTDFQIDPATIWESFSKKPRGDISHPFKIPICRLAPTTPRHTANAWFGKNLENEESTTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVX1</accession>
    <name>A0A401GVX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAUS augmin-like complex subunit 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0901980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617232.1">
        <property type="nucleotide sequence ID" value="XM_027761431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVX1"/>
    <dbReference type="GeneID" id="38783236"/>
    <dbReference type="InParanoid" id="A0A401GVX1"/>
    <dbReference type="OrthoDB" id="5575722at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028163">
        <property type="entry name" value="HAUS_6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14661">
        <property type="entry name" value="HAUS6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAUS augmin-like complex subunit 6 N-terminal" evidence="2">
        <location>
            <begin position="139"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="703" mass="77130" checksum="564F8278755A6853" modified="2019-05-08" version="1">MPPSNSKSTITALPVALPHSLLVLVHLHLLDYPLKQAAQYDERLFNSKTNGIRERTKAMEDICYFLLGRIEGRDRAKAILPMYPCLQPSDTTAFRVSLTKYLESLRHGIVHTNHKVSNSDNKGKMRDSTDTAGAWWWKDVVVRKSLLEECAGERFERLLLALSTHALFKKLSASPALSAEPGREELTALTSTYGALLAQSHSSRRVWERTASALTRRKADLQLLRERLSDPNANARRSTKYNALTTDRLLALRDSALSDLLRKSWRHAEGLIALDFLIDLAGLQGSHGASKHDGENSSRLSIVAVDVLDTKAPVALPIPPLPIAAAHHPAHLHTLMEPVFSSSTPTAPMNATVSAPARPKETIPFGVSERIDAAARMEEALQRALASAEAVRQQLQKRIQGGKAIPASNKSVLNLDLRSWAAPNPRTLDFHTAPTPGLLGTFSLPSVSPESALEEQIAQIRTALLPAYPPVPTQPVLCSDPLPVPVPPSRLRQPAQIGEVKALRRGAAGMSVNSGLARATSAHLRFAQEDAAASTQRNVHPRIASRRVSRRVRRSLAVRDEEVDKVVEAVRGESASFEVAEATPAHVGRTAGVPLSAVKSVPRPSYDMERHERAINVPLPRLRLSGADEDAHSEDDIPRHRSSEGGKAWTNNNWPDVKPEEEEYYEGQSITLKEILLKAGSDAAQFDLLGDSEDDLDEDFEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW25</accession>
    <name>A0A401GW25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0902940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617328.1">
        <property type="nucleotide sequence ID" value="XM_027761527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW25"/>
    <dbReference type="STRING" id="139825.A0A401GW25"/>
    <dbReference type="GeneID" id="38783332"/>
    <dbReference type="InParanoid" id="A0A401GW25"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581">
        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1034" mass="110113" checksum="582CC04B0603A4E4" modified="2019-05-08" version="1">MPSSSSSSSFVSPPPSPPKPMQLKGVRNRVVSKLRHPFRRTSKSGLHDIPDTATLDARLRDPLLVNVVRDVEPVPITIPVSPKSKASTDSMAASIKRGSSDDGSVASHPLSDSRHSETTSATSGHLEDSINSESPQEGLTTALSSIGEVTSSSYVSAQDGFATPSAEVYPFPVATPLVAVGSQYDDFLDIEPASEHAEEPVATLDFQFPPTAAAAIGEGILEVPPAAAELEVPAPFLILVDEPEQPRPEPEAEEDVEEEVHGLSVTEPDVAEEVTLAPLGAVEEGSAQSAADDEPAHAEPPDEAGVSIAQPLADEEVALVEPVTVDDEVAPVEPVAVDEEVALVEPIVVDDEAAVVESVAVGDGTALVEPVAVNDEAALIEPVAVDDEAALVEAVAAHDEAIVAHSPVEGEVALAKSSFEDEVALVELISVEDGVTVAHPPAEAEVELGQSSSDDEIALAKTVYVEDEVAVVHPLDDEIALAQLSADNEAVLAHLSADETILAQPPPAAEEVTVVSSAVDEVALPSVDDEDVFASPPAEDIEVAQPPAEDEDEVAQSSAEDEVVSAEDEVATVQPPADDDIALTQSPADDEVALQPPADDEVALQPPADDEVALVQIPADDKSALEQDPSSPDSATSMPLPSPNMNKEVPPPPPAESDEEDEEEAPELYLSSLTIPTMFLPIPNTDPLTTLLTKYISPEKRPVRDITGEWQRNDFNTLVMTNSWRALARMARDRIVEADPEDLSLILSLWSLRLSCLARLRLFNQTSAECTNLFTVLNAVEPAVSRVWLFDRVLPFELEVLHAKIKYWMGDHMGYLDALAALLRRCKAKARHAKVDDAMWKERGARVCLIIASQLIEMKDFSAAAKLLEPLCKQGPDTCSPQLESAVGRIYVQSGYLSMAAKHFTAVARNPASELSLKATNAALLASAEGNWTKAAEELRLLLASDPENYAAANNLSVALLCQGKIQEGIRMLEEVLRASPSTIVVAEPLIFNLSTMYELRSTVGVDKKRDLLVEVAKWAGDGVRTACLKMPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW56</accession>
    <name>A0A401GW56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor BYE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0903300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of transcription elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BYE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617364.1">
        <property type="nucleotide sequence ID" value="XM_027761563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW56"/>
    <dbReference type="FunCoup" id="A0A401GW56">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW56"/>
    <dbReference type="GeneID" id="38783368"/>
    <dbReference type="InParanoid" id="A0A401GW56"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21538">
        <property type="entry name" value="SPOC_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS central" evidence="9">
        <location>
            <begin position="185"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="866"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE86451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1010" mass="111019" checksum="31967F4BCE09932A" modified="2019-05-08" version="1">MIHCSECKEWYHFRCVQLSERDAEDIELYTCPPCHDKTGLRTIMEWEGPEAFELVPEQEQTPKQPAKVASWESAEEVVHEKEEEHISESDDSGDEYVVEARAKPVGKRRVRRVSSSSESDAESVASVARAPKRLRRASEVSKSVGARTHSPSPAPSSLTKRKKSISSQPDAKRRRSESTLGEDPARKYCLTKLQELFCQIFLRYPFLQEETHSDDPSENAQPDKKQEDLTDEDKQALEGKAKQFATDLEQCMYDLYSEPDKNGKHGVAGKYKERFRMLSFNLSKPDRVSLHMRIASSHITPKELSTMSSTDLANEETQQSIRQAEQEALAHSILKKQTLPRAKITHKGIQDIEDMNGGSREVEHEREEEEEEERIERERLARLKVQAQRAASSSVPPESPIVPQTPSWGGPPQAPSHAGEPAASSALSLGRPSLNPLFVPPASEFTGPVEGELNLADLINIDEEPSHDDNAMSVDSIPTPFGETPSLSTRQDSTPTVQTPPLVSPREPAGISPFAEKSSKPDLSSRPSFDLKALWSPKSADPGPEQQAGGAAEGATHDEAHHHHMDMDILGEEADDQDFDMFLGRDEEDKAAPEVVDNSPEAFRAAFEALPRIWSGTLSMPLDSTMAQEVSVDARQMGGRTLDNPLLWQTLFPTRELRIDGRVPVEKSAQYLTQMRLNPTKELIAAAFSPVVVPGFESQGFKNLVEHLTTKGRHGLVFPWGNRPKEHSPGRELYIIPLLSTDPIPDYMELLDDLRLPKLRNANYLIGIWVLNKGKLAPPPTPQGLLPPQVAHLAIDLSQLQQSSTTVPIPNIFSQAVPPSVTTPMAQPQPQPTAATSALAAEVASLTPEEIQLMLRTLSSAIPAQPAAPPVPAVAPPPAPPAQTGMSAIPIQPWGAPAPSFPPAYSPPNTAFSAQPSPPHPSRPYPDMPYDNYPHDQQEQGYGCPSGSQYGGRGGERGYRGRGGPPPRGRGRDRQRDAGWPKSRGRGRGGPGPSSPTRERGGRWGESRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW61</accession>
    <name>A0A401GW61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0903340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617368.1">
        <property type="nucleotide sequence ID" value="XM_027761567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW61"/>
    <dbReference type="GeneID" id="38783372"/>
    <dbReference type="InParanoid" id="A0A401GW61"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019204704" description="Chitinase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23159" checksum="71B09A25FBB00A8D" modified="2019-05-08" version="1">MVLFSIYGLLSAAVLVLTQVNGVNSTPAHDEPDRQTRDISTRSTPDAPHWVAYWDKSTSGVSGAPNASDLTGYNTFILAFLLLEGAWDNAEEWTELAVDERSTILSEYSAAGISMIVSCFGSSDVPTTSGADPTDTANTFAAWVIEYDLDGIDVDYEDFDAFDAGTAEAWLVTFTQQLRTQLPEGQYILTHAPVAPWFGPNIWTNGGYLQIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWS6</accession>
    <name>A0A401GWS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0905570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617590.1">
        <property type="nucleotide sequence ID" value="XM_027761789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWS6"/>
    <dbReference type="STRING" id="139825.A0A401GWS6"/>
    <dbReference type="GeneID" id="38783594"/>
    <dbReference type="InParanoid" id="A0A401GWS6"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019416363" evidence="5">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="129"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="35437" checksum="25F01F82BBE52D86" modified="2019-05-08" version="1">MVSFPFLGIAALTALPVTKAVPTGLDNLARRQAITALSESQINYFTPYTLYASAAYCPSAELAVWACGVNCQAIPQFEPVAAGGDGNLVQYWYVGFDPTLDSVIVAHQGTDPAALLADLTDVNLIQEALDPTLFPGLSTDILVHSGFANEQSLTAADVLSAVQETMAKYGVNQVTIVGHSLGKFSSFLTAFNLSDQSDTQERQSPFSTPYTFLFIFRTRRSLISDTAFHEWVGNQAFANYVDAGLTNVTHVNDKKDVIAIVPPTSLGFIHPSGEVHIEDWGDWDACPGQENPSPLCIVGDVPTVLQGNIVDHLGPYNGIWIGCGVQTIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWZ3</accession>
    <name>A0A401GWZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0905830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617616.1">
        <property type="nucleotide sequence ID" value="XM_027761815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWZ3"/>
    <dbReference type="STRING" id="139825.A0A401GWZ3"/>
    <dbReference type="GeneID" id="38783620"/>
    <dbReference type="InParanoid" id="A0A401GWZ3"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="197" mass="22090" checksum="8C765B7E7B612E2A" modified="2019-05-08" version="1">MAPYFETAKSFADVPITDEGVDTASFLVSSTDFVNMFGLLGSGVFAFVQADLKSNIGGVRSRYEATSDRSTTLEKLVLYEAERHECHGTACLVRLIRGLLFACQALQNMQNDDSSELHICFKRSYDTNLRHHHSFIVRSAVSVAIRAVPHRRDFYIRLTQGGSHEKFDAELTKWLAGLETIVMRMKAFLENGGYGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX37</accession>
    <name>A0A401GX37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1000190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617690.1">
        <property type="nucleotide sequence ID" value="XM_027761889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX37"/>
    <dbReference type="GeneID" id="38783694"/>
    <dbReference type="InParanoid" id="A0A401GX37"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="96" mass="10772" checksum="EF4F86907042BDBD" modified="2019-05-08" version="1">MRRGSLQRRWVTGHQQTKYGHRRRARRGVRSSVSVRSGDDDIIATSATLHEQPDWPARAALAPANRPLAAPARWRPLRRAPAVRRRAHLLARAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXA5</accession>
    <name>A0A401GXA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 79 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1001080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617779.1">
        <property type="nucleotide sequence ID" value="XM_027761978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXA5"/>
    <dbReference type="STRING" id="139825.A0A401GXA5"/>
    <dbReference type="GeneID" id="38783783"/>
    <dbReference type="InParanoid" id="A0A401GXA5"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019525041" evidence="3">
        <location>
            <begin position="18"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="4">
        <location>
            <begin position="473"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE86866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="674" mass="71114" checksum="BE3EF1D77489A46D" modified="2019-05-08" version="1">MTPRALILLLFCRVVSAVTLYGVQGVLTPGVPTTTPDTASGTSVYDPPTETGLQAFNPVILAPPAVPSPPITNQFWLPLSNSAQNAANNYNVSIQQDGAFLGLSIEMSVINQVIGLNGSFLHVPFLNLMALVAERAGSVRVRVGGNTQDYAVEVDSLPDYKMVMKDKADSRDTTETPTMYWTPEMLYLLSNVSSHVNVKWWLGIPFNDTSNLRLQIAEMGEAILGDKIIGFQLGNEPDLYAMHNHRPANYNASDYFNDFAMVSGAISDDPQIPVHNNLVAPGVSGTWTPEQVWDTGFVPAFSDVLNALAVEHYPENNCAAQFPNEGFGPPVDPQSIFPTYLTHASGQGIVAAYLNSANIAQQAGKPLLMFETNTASCGGFPGVSDSFGAALWGIDYSLQMAYSNFSGANMHVGGVDDSYNPFTPPPSNLSSWAQWTIGPIFYSIIVSAEALGSTGTAQVVDLNANSYNPYTPAYAIYEQGTLARVALVNYLSDTSGASTLTVNVTVGGAGTVESASTPAQVRVKYLLAESVAVKEGFTWAGQTMGNRFASDGRLLGNETVQTVQCDQSTNTCQVTVPAPGFALVFMTDTAFDDASPSSTATFATTTHTYGALTVRVSPSVLATSNGDNAGDRDDLGSTSKGSSGAERSAGVASGVVALVALLAGASVLRGALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXE7</accession>
    <name>A0A401GXE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617819.1">
        <property type="nucleotide sequence ID" value="XM_027762018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXE7"/>
    <dbReference type="GeneID" id="38783823"/>
    <dbReference type="InParanoid" id="A0A401GXE7"/>
    <dbReference type="OrthoDB" id="2758182at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="941" mass="103491" checksum="B4D4845D161ADE92" modified="2019-05-08" version="1">MEHQLILSEKLRSYDMADAKGRKTLVQSLRQKLKTQFVDTSNYDDIIVETKIREWLNNHACHVQEKAMKKRMHVSGKPNAFKVWDALERDKEVTEAVRALTADKDCNVSKVWRVAWSAEWAKLSEEEQKVYEEKAESWCNGTLDDKTKMKLREQRMMQYLKKFAKTMWDTMGIRMAFMLAYPKEAGSLKVEMVEVNHAITNGTPFGAYPGWLRAYQPLAKVFSEWAKGEYGVTETTVTVKKTPADCMRAMDKIQLTANGFPLLPSVPEGMAEAPLKVMKVQVRDFMNHHYALAKGVRNCKSPWTKLNSIDDINEVIPAEMLPENFQWIDPSKMTSVPYFDKDGEAAPAKYDPLPPLDGSAQALEEGSEHEVQEALTPKKAGKAKKKGKPVRKVTGKAASKATKGKAAPGRAKGGGRKRKMKDAYDSEDDARSSQDSDRSSPDIPSMASEEDTASDEDSGDGESVIANKVKGKAVATTNGRKANNGGAPQASGSGGAKTKAKRGLQDLPLGELHRFDTEETDEASSELEPSTKELRLELQGRAPHLTGGSTVGSTVPHLVKRRDVFLATLSVEPRYQDMLKEVKIATVPQVYHFARYDPIPWSEWSYGQRYLPPSFHAVDNFDIVENWLGDKPWLTKYRFLHPQGVQQSALVIGMALRDLTQSQFIEEGEPTNLPDYVVNSAISFDAVEQLLRCCEIITLDMVEGNVTHAMVKPVSKPAIRGAPQGGDGLGGQEEQEGDASARTHDGAATAAKVHKAHQPAPMADKPIIPSGGDEGPSQETSGGASDDGEEDDAHLSVPSSGAERPPPPPFIPKMRKAAATEDRPSGQAKALQGRSITDALQSNIPGRITRSQRQAMDESPAKNTRSQHPLGAVKDLKKLPDPKRKRQPARPEPDGEDSSGEDNPPPRKRGCGTRDELVVASPRKKNARAEDSDDGDKPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY77</accession>
    <name>A0A401GY77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1003990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618065.1">
        <property type="nucleotide sequence ID" value="XM_027762264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY77"/>
    <dbReference type="GeneID" id="38784069"/>
    <dbReference type="InParanoid" id="A0A401GY77"/>
    <dbReference type="OrthoDB" id="2740399at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="32262" checksum="7C679D6D3CE3D576" modified="2019-05-08" version="1">MPRAAVLRKKGLTIQNREAKIQQAVDGVKNGTYATPKIAACALSIGSQYTTIWRWLNNKTRPQYEAHQAKQLLNHAQERTLVAWTKWLGFTGQPVMRETISPKVKALCGKDPNPKWIERFLMRNPDCTMGRPADLDPKRASAFNYTTVNHHFEELQKTIDLYDIPPCNMFNFDEIGIQLGGGRKGSREQFFFASEDQSHYKLKSDDLELVTVLETVCADGSSTVKPGFVFAGVKMCEEWISEEDGIFLSTTDNGWTDDHVSQEWFQRALSLPPKLIVILRSQCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYB9</accession>
    <name>A0A401GYB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1004270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618093.1">
        <property type="nucleotide sequence ID" value="XM_027762292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYB9"/>
    <dbReference type="GeneID" id="38784097"/>
    <dbReference type="InParanoid" id="A0A401GYB9"/>
    <dbReference type="OrthoDB" id="3060725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="348" mass="39021" checksum="E8DDD4A1F980EB93" modified="2019-05-08" version="1">MASVAGNQLPTCYKTRCQDGTYDRIMAQLSKSLDQMLALKDYPADFAHTTNRKGHYEYYSTGDNPSEFSALIIGQVMVSEWGTDLYAKGNFRPYDDNKITDDTAVQNTLVLCVPSQATTDLTEFYYDQIGTLNDIRMMDEKEEEIANFRVTEWIRPSSMEPGKPSDLIIVTIADPKYTTHTNLPIKAAATATPKVEHIKKKRTANAEAEKMQDVQQELTKPTGDDIRIGANYDPHLLPDYGGDLFDHQKARLHQHDFRGVDGMLIPPWDWFTTLWRGTLVLLNVQAHNLCVLSESNEFCIIPRPTLGPIICASTHSSNPPAAFTEFDASPPKKAKADVTKEKVKAKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYR6</accession>
    <name>A0A401GYR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1005520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618217.1">
        <property type="nucleotide sequence ID" value="XM_027762416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYR6"/>
    <dbReference type="GeneID" id="38784221"/>
    <dbReference type="InParanoid" id="A0A401GYR6"/>
    <dbReference type="OrthoDB" id="3232438at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="228" mass="26460" checksum="8C5E3C32141B0BF9" modified="2019-05-08" version="1">MTKWLERREKVIHLAKYIIWRSHQAVSAENIIAVAYERRWEPPDMACALHQKMTRHPTRKGVDLELLASPSHYGATFFVPALARFIAQYNNPTLSIQQIEECAATIRFPFHSVPVFHKIKFWNEEVHGKETLDSIHAHPRIFDKDGDVVVPAPFDTALIQVRAARLEDLVGSTLQAKRVGQIRLKFCLCRRQPWDFFLITVLHLATLLTWNGFRNSRHLLTQTSRCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H032</accession>
    <name>A0A401H032_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1104160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618652.1">
        <property type="nucleotide sequence ID" value="XM_027762851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H032"/>
    <dbReference type="GeneID" id="38784656"/>
    <dbReference type="InParanoid" id="A0A401H032"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="287" mass="32380" checksum="C28A63D7F7B80E18" modified="2019-05-08" version="1">MLRKMASRPRHMYLNIVWSSDGLSLGVLENFTECLQTFELLDGFLDLPGESEPSRTWPHVQSLHLADSITSIAMSHISLAFPNTRSFKCSATCSFAPQSPSHWAYLDEAEAPTCAPLIFPIRRLVLLDSGEEAMLAIVRHTSPVVLICSAFPEFFADVPPVAPDLKYLTIDSPGMNGEVSDIKSMSVLIARSLCTLPLVALSFRYKQRRFSTPIPMPTLKDIAQEVAAELPTLNYIHFDVRISRSKKKRIQQWYYVTLRQDGLAHMRSLNEQESGILKQRLDKLDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0F6</accession>
    <name>A0A401H0F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1201410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618829.1">
        <property type="nucleotide sequence ID" value="XM_027763028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0F6"/>
    <dbReference type="STRING" id="139825.A0A401H0F6"/>
    <dbReference type="GeneID" id="38784833"/>
    <dbReference type="InParanoid" id="A0A401H0F6"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="591" mass="61662" checksum="9A8F8676E62A5656" modified="2019-05-08" version="1">MATPSSSTTTPSPQLRFLQTSAAAPPVAANINTTVTANDKEERDRAVEKFLARAEIAKLTRGLRTRLSYASYKATHNVAHNTLPDLEAQSQSQGANTRNAQGRTAGNYYNNPATQGNSAMSPGTSARAAPRKGSMAPPPPVTASATQSLFASILAPPPAKRPRTIHNPQDPPVPAPTRMTGAPSPLHKSSKTRVAEGSQAKSKARKPARGKGKGKEHANAPARAAAANSAEVDVDMQVAATLTSLMLSRQSIPTNASSPRSSLSAGSDAGSTQSFSQYAQSSARTVTAAASTSAQGRQSTPAPGGRQRRELSRDRGRGEGQLTPKPLHRVVSRVGASDTPHQPSDTEAADLMLFLATSPSPVRPAVTRDARDVAFRGLGGSSLKGRALFSSLSGNPSLDAQRPLRREDTGSFASSITAVNDYPDAIPGEGANRKLSRSPPPKLGVSQGTDSSFLDVPMEPTITPPTPTDHTAVQLLPAPQSPFQEDRSRTTRSPTFTDRPSSAALRPGFPPPDGKKVASPPPFYISDFVNVSPSPAAGAGPQSRHGTSLSVDIGGRRLFDDSRGLNGSGRRTDSATGRRSGLGTGIDLVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1C0</accession>
    <name>A0A401H1C0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1300280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619127.1">
        <property type="nucleotide sequence ID" value="XM_027763326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1C0"/>
    <dbReference type="GeneID" id="38785131"/>
    <dbReference type="InParanoid" id="A0A401H1C0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="225" mass="24507" checksum="1D426A4958096A23" modified="2019-05-08" version="1">MHQSLSTPKARRNHVHSAVHRLEHSPTLAHSMARVARIPVPAVTLPVSTIPPIAAYAGLRTMHPGTANDRRVESYQRHQRPSSRAARASGELNAATVRCGTSTTVTQRFRAAATTQSTSAGAPRSTGQDEMHTSFMVGFLPFVPRGSVYSAPDEASPEYKWDGDQVAAVQRTLGQANLLFQIDFRVVDGPVWDAFDQQIIEHCELFEITLAQRSSGTPRAPSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1C4</accession>
    <name>A0A401H1C4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1300510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619149.1">
        <property type="nucleotide sequence ID" value="XM_027763348.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="38785153"/>
    <dbReference type="InParanoid" id="A0A401H1C4"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47734" checksum="55FBD05D8A333FB6" modified="2019-05-08" version="1">MAILRIQWVAMEFERKVSAPALPVRRVQNFSGGLLTKSFSPAPPSWLGIVGWPRHPVSGIDFLAVGFLCGWSCGGGCSIVDCGAWRTGASGRSCGCDPGDVIASSQCDHVGVHLRYVRGAFGLFTFLFSLDKCERRQNTFTATMPLFSSLFPAAASAYALQAALALIFVPQANEKFYDLGGALGFLSTTVVSLYYPSVKARFWDGKIFVNIPQLNSLAPRQMLLNVALVVWSVRLGSFLITRAIKAGGDSRFDEVKYQPAKFTAYWMAQATWVFAVGLPVYLVNTLPASAHPPLGPLDYISVAFFAGSWLFEIIADRQKAAWRRAKDKKEHDEKFITSGLWGISRHPNYIGEVGLWTGIWLLSTRSLRTPYFPRSAWLLAGVSPLLTWFLLRNVSGVPLLEKAGDEKYGNDPKWQEYKRSVPIFWPWGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1I6</accession>
    <name>A0A401H1I6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YIL156W-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619210.1">
        <property type="nucleotide sequence ID" value="XM_027763409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1I6"/>
    <dbReference type="STRING" id="139825.A0A401H1I6"/>
    <dbReference type="GeneID" id="38785214"/>
    <dbReference type="InParanoid" id="A0A401H1I6"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF3">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019073188" evidence="1">
        <location>
            <begin position="23"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="7961" checksum="3C29A2F179BB01E7" modified="2019-05-08" version="1">MGGLGKLFHLAVDAVLVSTVVAGVRRSSGFTPETAVITEPTLRSVAERYLGIGETVFDMIQGSAVTSKYFKRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Q6</accession>
    <name>A0A401H1Q6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619251.1">
        <property type="nucleotide sequence ID" value="XM_027763450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1Q6"/>
    <dbReference type="STRING" id="139825.A0A401H1Q6"/>
    <dbReference type="GeneID" id="38785255"/>
    <dbReference type="InParanoid" id="A0A401H1Q6"/>
    <dbReference type="OrthoDB" id="2803524at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="633" mass="66775" checksum="6B3001DD8CDF615A" modified="2019-05-08" version="1">MFYAERIKTHVEAAKQSEKPSHSEALNLVNRVTVKCFEAEEEWVKQKVLDAVEARKKAAGSDGNYNDGGAEISPCQYQDAIDDMPIVFKQVLNKMAEDSGLHIMLVAGGPCPEEGGDIITFACVPVSFIPVFMMHFGTNETSHTFGDVQPGVMAQFMNVFIEHLKTVFSPEIRLQRALEVLSQPDVSMTITASDAAGPSSAVDITMASTEDLMAKPLTPQLSSPMLPSVSLPPSSPLPPSSPLPLSSSLPPSSPCPSSSLQHSSPLLHSLLLSPSSSMSQGAFIHVANPVGPSLFDMTNNSGYVPADLNSTLELPPHGWGVPWPSMSDLEGEQIPWLNFNPASWTPDMTDWAINDLNLGVGTSAASSTVCDIHDVARLRLPEPSNNWGQTPFSRWPVQLEPGIPFQQNLPATSIVDADPVSVAIVAPAMSRNNAAAVCPDGVPVHIIPPVIPAGSASGITSASVPYQADVSTIMVHSSISTSLSVTEQSGSGSAQIIPPAMVAGPDNMVPSSACMIPEVTTPNSSGNVQSHSNTAALQPGEPLPPPQPTEDSAMSDPPGTGETPPTSALVCPSHAHKVPPTADSIWQLTAAQVRRFGLSAAKNGSKMTKRKSTVKENEGQSGDTANGPKRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Q9</accession>
    <name>A0A401H1Q9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho1 guanine nucleotide exchange factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1301920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619290.1">
        <property type="nucleotide sequence ID" value="XM_027763489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1Q9"/>
    <dbReference type="STRING" id="139825.A0A401H1Q9"/>
    <dbReference type="GeneID" id="38785294"/>
    <dbReference type="InParanoid" id="A0A401H1Q9"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="199"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="423"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="580"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="943" mass="106367" checksum="E53E2578444B2394" modified="2019-05-08" version="1">MASRPHPHVRIPTPGAVPPAVDVSPSSSWSHLLQSPPQNARNTYADLNSFTSSLLRSGTSAPRISLDAPSRPHSRASSTFQPDTTTMAFPEPQLFRSSSQSSSVHPNSFLSHSIARSEDLLSPDFSPLYSGSRPPSFISIDSSPDLSPSVLSEELSNQTLESEEGLRRFQSGDLPENDEEWYRLVPAEAREVLGKIEVQRQSNLFEIIKSERDYVKDLNLLKEVFIEPLGYTPTISKSRSKDFVKGVFSNLDQILAHHTRMLDALFVRQREQHPLIQSLADIILDACVHFQEEYKEYIEHYPLAEARHRDEMRRNQRYNDYIQQCSLDPRTRKRDLITFITRPVTRLPRLRLQLDTLSKHTMADHPDAEQLPLIMDTLSLVLDSIQPGIADAEDKVKYWNLCESLMYDKGEIIDLDLYGDNRTLVHSGPLARKYRSEVSYNWADLHVALLDNYLLQLKPETRSDGRVKRRVVSRPIPLEYLRLDKFDGPTDNRKEKQDEGRLFEGFRSHSREMYPFTISHASSKSYTLYTTNNEERKEWRDSLINAVAIRRAKQDGNKWFASQVVSDGFFRLTPTNGVFTGKILSAVPFVSGGKNYTAVGCSSGVYIARRGVADFKKILDKPNTVGMAALPDFNKFIVHCDVGLLSYSLELLVRVATGASPLENLDASLERVSPDSTVLFFRAGQMEYRRGDQLVSRTMVLYTSRWFLQFSVNAVEVVRPLEHSSGVPRTSSVGLPSLSFRPFGDAVYISKEPHNIVALNQKVGVCTDRNITLLDPTNLNTSSLAPTVMPNFAGADAALTLDILKSRSSGKKVLGLVPCGDETLVVFDELGCYVDKHGIPCRKYGYLRWESKATSYAHRGRHLLLFCSKFIEVRTVDKGKLVQVIEGEDVRLVHTGLLPEDKTTLFAMKGRDHRGAVVDKLVELVETSPLISERPLENWDDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1X1</accession>
    <name>A0A401H1X1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1302290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619327.1">
        <property type="nucleotide sequence ID" value="XM_027763526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1X1"/>
    <dbReference type="FunCoup" id="A0A401H1X1">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1X1"/>
    <dbReference type="GeneID" id="38785331"/>
    <dbReference type="InParanoid" id="A0A401H1X1"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="293" mass="33612" checksum="BD5326FC5951DD34" modified="2019-05-08" version="1">MFRRIVEDISTGSDSDYSNSVQWFSPCPPRCIDRVLQWISWFLSSKGNEYFCEVEEDYILDRFNLTGLNTEVQHYSQALDLITDNLDDEIQDEFRGTLDVQARLLYGMIHARWIVTARGLAKMLDKYKKADFGRCPRVLCQSQPLLPVGLTDIPYEKSVKLYCGRCEDIYSPKSSRHGSIDGAYFGTSFPHLLFLVYPSLIPPKSGPVDFAPAMRAGGDVEGNRRSRRMREEQEPLVECVGADFSTASAALKADRYRPRIFGFQVNEIAKLQRWQEAVRDRQIARLEDLEENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2J6</accession>
    <name>A0A401H2J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619557.1">
        <property type="nucleotide sequence ID" value="XM_027763756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2J6"/>
    <dbReference type="GeneID" id="38785561"/>
    <dbReference type="InParanoid" id="A0A401H2J6"/>
    <dbReference type="OrthoDB" id="2796904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="165" mass="18739" checksum="642BEDB685909EC1" modified="2019-05-08" version="1">MPAKKGKNCALSSTTTSSKVSFFSGRTAALKKLSAKVFESHAHKTDGPNLRKPKIAKLTEKQRCRALAIWNEWMNEVHPTVDPNQVWVDLCRQDATAMQYCKTFLQIHVETSVYQHVLLDDADGREEIEERSIKSSRSLNTFWKSLIAAADDEILLPMRENPDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3J7</accession>
    <name>A0A401H3J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1500180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619929.1">
        <property type="nucleotide sequence ID" value="XM_027764128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3J7"/>
    <dbReference type="STRING" id="139825.A0A401H3J7"/>
    <dbReference type="GeneID" id="38785933"/>
    <dbReference type="InParanoid" id="A0A401H3J7"/>
    <dbReference type="OrthoDB" id="3241983at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32258" checksum="80178A94BA3FE360" modified="2019-05-08" version="1">MVYAKLSSTKTRAAPSAKVRSSPPTQPYVPPPYHIGYFAFPPVANVAGKGRPGNPSFMFSFYDDRKAREEQARAAREEQERVAREAREAEIHAKERAWEERCRRAAQAREEQLARERAEALKGEMWWVRFGFYLLDERGHKLVERTEALRAEVRILDEETRRLTMWNAYESRWRELFASSTPVAFKDVPWPLPATLSSVDELADSEAAIEEFIFATLIVRTNTVTRRERLRASLLRWHPDKVSAVFVRVVPEDMEAVRDGINTVFRHLKALQDKERQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3V6</accession>
    <name>A0A401H3V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1501200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620030.1">
        <property type="nucleotide sequence ID" value="XM_027764229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3V6"/>
    <dbReference type="STRING" id="139825.A0A401H3V6"/>
    <dbReference type="GeneID" id="38786034"/>
    <dbReference type="InParanoid" id="A0A401H3V6"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="25"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE89117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="639" mass="70963" checksum="53CA1944877E4985" modified="2019-05-08" version="1">MIAKVLNSVEEPVVLHEELQTTFSGVVHSISTPDAAVHQYRGIKYASIPARFRQSRLFTTYPPQTDATRFGPICPQPRYKTVEEELFGIADDSIPQQHLKQSEADCLNLNITCPADATPDSHLPVMLWTHGGGCRGSGSSWIFDGGSLVQKSIQIGKPVIVVTFNYRLGLLGCAASLALREDNRVAGDDGVGNYGLRDQRRAHQWVYCFISEFGGNPLNITLFGESSGAADILCHLHSAANDTHPLFRRAIIQSAQTDFEVPNLHAAGSQLSKIMSALRVHTLEELRAVDPEKLVSLSTTMRAVDDGTFFRQGFAGFLVPLESDEYHHLSEEQLARHSPELIPHSNPLKTAHRLLHQFSQPYKDSRSRSHSHHRHPLQPIMIGDCGDESLLWSLTASLWTASGVVRRVRAVCQSLTKANALLRAYDINAYTPVDELPQRVLELINDSRFAWPTECIAASHKRERGGRGVWRYVFDQEGPARGVPHHAVDLIYLFDNVPLPSVVPTVSGDGCPTDSGPECFFSSDSEAEDSGSDYAYGDSSESGSIEEWAMPVVDDWTYSRVRDAVQERWIAFAYGEAPWQEEKVYVFGPEGEIGERSRSIFDGRRRTQLWRDALEPLGMHLVQKLGTELSNGPPCPARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3W9</accession>
    <name>A0A401H3W9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1500420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619953.1">
        <property type="nucleotide sequence ID" value="XM_027764152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3W9"/>
    <dbReference type="GeneID" id="38785957"/>
    <dbReference type="InParanoid" id="A0A401H3W9"/>
    <dbReference type="OrthoDB" id="2801792at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="366" mass="40496" checksum="FCD02CC4A3A49050" modified="2019-05-08" version="1">MSSPFQYRNQLGLLTERYEQPRDDRMSCGAGPSQSVARSFLGAGWPTGSRNEDSLAGTAESTSTVDLLGNLFSDIPIANYESSRSFPSSSFYPDRHRTDLASHIPVGQQRVGQCAPFTPSNDIFNAYSGPNDTGVPGVEYDIFHQGENYVCPPDYPCRSPALGIYQDPGIDVATVPAATLPPQMTIAHAQAQRVLSPVVSSAASMTSRGRPPFGRQFRPVHSRLHDHRLTGPYPVPSTSRTLIEQPELAVPASDPAALSPFRTRCFWEGQCNVLLDDMTPGGVERHLRAVHIHEQWNRIVRGECRWHTGDERCGRMMAQGGFDKHVASKHLRSTSVMCNVCRKMFCRKDVLWKHRKAHCRGVPGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H401</accession>
    <name>A0A401H401_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1501650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620071.1">
        <property type="nucleotide sequence ID" value="XM_027764270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H401"/>
    <dbReference type="GeneID" id="38786075"/>
    <dbReference type="InParanoid" id="A0A401H401"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="43"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="503" mass="54484" checksum="894F8B86DB81983A" modified="2019-05-08" version="1">MQFTITERDESGRINVAFSTTSASGKPPGEYLGVVEADKGRTNWRLFLANVFLPAGYPTSVSPDYLQYQIYNAVQAFCSSLSGLIASRAVLEGHGVGNASASATHAIFLTVIQDVFGRLTTVIAGYYLGTSLFPEAKTYRLLADIFNDAAILLDALSPHLTSVSISLRYPFVSYGSSSYLRVVSLCLSGTFRALCGVVAGGSKAALTVHFATSGNRIGDVGDLNAKDGSKETVLALLGMLGGTVVMHYVHSSGPTYLVFFMLLFCHLAANYVAVRAVVMRSFNRQRANIVWMAYRAKFAEGNKAILTPEAVARRERIFGNPATLYDASSPRLRLGFCKIGAPFASILSSHHSIRSNSGDARFRGSDGDLSVSQVHAILEVFTDERYVLWFDPNPQHTSLHLRICMKEGHTAIDHLKGWAHALELALHVVGSVPNTFDERIGAVRTSLCKVMDMFPSFLQSAQTSGWRTDEGGLLAGSARALSVKYGQDLEGEAVVGKEDRKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H452</accession>
    <name>A0A401H452_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1502240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620129.1">
        <property type="nucleotide sequence ID" value="XM_027764328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H452"/>
    <dbReference type="STRING" id="139825.A0A401H452"/>
    <dbReference type="GeneID" id="38786133"/>
    <dbReference type="InParanoid" id="A0A401H452"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="1">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="2">
        <location>
            <begin position="251"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="496" mass="55265" checksum="D33CDA458418AE23" modified="2019-05-08" version="1">MEGVAALTTEDHEALAGVLPGAAFFQSVFDFDLHVAGLFKAVSVTSSEVVFSQLALSVAPPGVWYAVIRGLTDLGFYEDAYATLVSTPYEKLKRECVSQLMYRMCEDHAVDRLMALNFTGFVDEVEESLSFKARNADSRSSSFSQGNVILNHVSRTSAALTMYQRARKLASLFGDPANFIEIAELQFETYVVGMNALALTDQENAWIVLPVTAESEHEEVVIVQPCKRRKLSRYIPEDKYGPGKRDMEVVELADMQYEYTLLAIRLELIRRDPTLLSAGEALVSPPSVVLRLTQANRFNMAMATARTLNVDITDLFGHLTGLCLRPSRNPEAVIGEDTSDWLLTDKVTSWPGTAADRGWRYLRKSLERHDGPDTDYRYTKVTLDHLRTRSHITTPTMVDSVARGKFSTRSHCGRIANSPAAGALERTLSLMRRSDAHLAQEKPAAASVTCLPYTLIDQVLAAVDTQEGFLIRAQSLRKELRTEISNRIKRVQKFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H464</accession>
    <name>A0A401H464_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1501460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620053.1">
        <property type="nucleotide sequence ID" value="XM_027764252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H464"/>
    <dbReference type="GeneID" id="38786057"/>
    <dbReference type="InParanoid" id="A0A401H464"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="119" mass="13776" checksum="9BD5088F41E051F3" modified="2019-05-08" version="1">MSEASVQTVARPRKRQFPRGYAYPINYSVYAPLAEELGITGVTLTNLNAYWQFRFKLMNACDVPNKCFQGIGLEGSTSMAVVFADNYTRERMKVDEELVQRVKKFLKTEEDPKWYFLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4A9</accession>
    <name>A0A401H4A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1502750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620180.1">
        <property type="nucleotide sequence ID" value="XM_027764379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4A9"/>
    <dbReference type="STRING" id="139825.A0A401H4A9"/>
    <dbReference type="GeneID" id="38786184"/>
    <dbReference type="InParanoid" id="A0A401H4A9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="16038" checksum="99DE10F5A6D29398" modified="2019-05-08" version="1">MSHEDSVHYDFETPIGDAEWNATLPSGGVLLHLGPKLRPFSLSMFHQMRCLNIIRGGLAALYADGTPGARLRQPNLTRHCMNYLRQMVLCRADLRLESVRAPRGYKLATSEVTHACQDWNAVYSAAEENYAQYLITLEEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4V7</accession>
    <name>A0A401H4V7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1601370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620388.1">
        <property type="nucleotide sequence ID" value="XM_027764587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4V7"/>
    <dbReference type="GeneID" id="38786392"/>
    <dbReference type="InParanoid" id="A0A401H4V7"/>
    <dbReference type="OrthoDB" id="2804332at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="146" mass="16331" checksum="33A028967E33F50C" modified="2019-05-08" version="1">MNDTNIAHSLFRIGIPFWFIQTKTEKTKIEKWASPVLVSYELSLEMSWPRLLRHEMDLAGILHRAGEWPARMLHEAMAAVCTAGLPPLEGTSEVSTAEQPPQKKQKDDKLPSMQLPTTQQSDGRADLQPSGSAESAKKSKRMHHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H570</accession>
    <name>A0A401H570_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1602510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620501.1">
        <property type="nucleotide sequence ID" value="XM_027764700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H570"/>
    <dbReference type="GeneID" id="38786505"/>
    <dbReference type="InParanoid" id="A0A401H570"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="15454" checksum="2C902B9C3F6112C4" modified="2019-05-08" version="1">MLSDKFTSLLGLPFASRAVLKARDHVQIYHQSPPKYCRDSQENGVVFSRPQAVVTSTDDGLLDLQSPRLIWAGIYVTPQHRRTPLMEAVTVCRRASESVRLDSLRSDASRISTIHQGCSHCQEQKEVHCVGHALGICLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5I1</accession>
    <name>A0A401H5I1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1602730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620523.1">
        <property type="nucleotide sequence ID" value="XM_027764722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5I1"/>
    <dbReference type="FunCoup" id="A0A401H5I1">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H5I1"/>
    <dbReference type="GeneID" id="38786527"/>
    <dbReference type="InParanoid" id="A0A401H5I1"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="38"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="545"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114927" checksum="277E4707DD0207F7" modified="2019-05-08" version="1">MEKVERLVRTWIASEREEEVQTIISEIAAGNVTLLQIVKALGEYLTADEDDLRTKGVEFLSLVLGRCPPEKLNRHSVRVLVTFYCGKLEDTETIIPALKGLLSLTSMPLFASNDAVEVMKALVKHVKMKALIQSQRFMVFTILDTLVARHRDAMKGMGNEFLSGYISLAEGEKDPRNLLLAFSIARVILIEFDTASHVEDFFNITFCYFPITFRPPPDDPYGIITDDLKTALRGCLNATPAFGPLAIPLLLEKLMAGTPVTKRDTLQAFDLGLPVYGPAVARNFARKMWNSLKLEIFQPTDTETEQAALKTTQILVQTIYAADDTEDKSGEDIEGLAKEACEECIQILREPEKSQAQPAIKVICAFMSTTPSVARFTLSRAAPHLVRLFLNPDEVANRAPVLRLLSDLIKAARDSMSRDPEVLPTEGDTPLSPFKDEIIGVLTVGLKTASSSQPALGGLKEMVLTPGLLTDEELGFVVHNVNELLQKEGEEGDEISEPALDLLSTISLSAPWHVSQTTLPLLFGSLPDKAPPRDAEAERIKYWRTLASLEQLCKQPDLFETLVVRLSTKLDLVCVPPAEPEQDTEPSAAYAHSLLRTLVDVLAAKVDLAHTDVVKYIDRLVPRLYNLFIYSALVSNSESMVATDPRLVSVAARVITLVVQTLPSQRQEAFTAVLFAGYLHGDIKRLAEGQQKIPSDRLFDPFNAGASPAQKNLLALFSSAIVALHKEVQLPIPDECAFLDTLLQWIGEHANNALQKDAITHSVASIINKRAEGLSTFLSEKLDAFWAAQIAESSNSAERRRQAILVWSWMTKALLMRGHPSAMRNTDRLFELFGDTEIHWDAAKAIGKIVGADKVLTRRNHAVVKILFAQRFCTSVLPRIVAGAKSAEQPSQQTAYLVALTSLIKAVPKSTYSHEMPTLMPLLLRGLDLPDAEIRSNVIDTLLAAAQSGAKETESSIVSEHAASLVSTMLRNSMVHETASVRVRIAALRYLAILPNIVRYDVLHPQKALVLRELAKVLDDPKRAVRKEAVEARTNWFKFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5P1</accession>
    <name>A0A401H5P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Versicolorin reductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1700350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620624.1">
        <property type="nucleotide sequence ID" value="XM_027764823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5P1"/>
    <dbReference type="STRING" id="139825.A0A401H5P1"/>
    <dbReference type="GeneID" id="38786628"/>
    <dbReference type="InParanoid" id="A0A401H5P1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05362">
        <property type="entry name" value="THN_reductase-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="254" mass="26642" checksum="21C2BDA6299F11E4" modified="2019-05-08" version="1">MTLPLAGKVALVTGASRGIGAAISRRLAADGANVVVNYVSNPSAAAAVVDSINAQTARGGGRAISVKADVGSTERGAHLIQETIREFGKLDILVLNAGIMGNASLTEVTEEFFDRHFQVNVKAPFFMVKAAAPLMKSGGRIILFSTSLTQNSMIAPNYLVYAATKGAVEQMTRVLSKDLGAKGLTVNAISPGPIDTDLFRTGKTEQVFNAIANMHPLKRVGQPDEVSPAVAFLARDDASWVNGQILMVNGGFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H621</accession>
    <name>A0A401H621_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1701580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620746.1">
        <property type="nucleotide sequence ID" value="XM_027764945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H621"/>
    <dbReference type="STRING" id="139825.A0A401H621"/>
    <dbReference type="GeneID" id="38786750"/>
    <dbReference type="InParanoid" id="A0A401H621"/>
    <dbReference type="OrthoDB" id="2757513at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="937" mass="102619" checksum="FC644078763A914F" modified="2019-05-08" version="1">MQTALPSSTIESRGWYVILGGQRPGIVDTPPIMSGGKFSPALPVLVKCHTQAQAEDVERFNDVVKPLKHLDETTTEAIVDLINQSSVTPTILRAHQNFWCVVYGNRSGIFMSNTEAIAQVNGMTKAIFRRISEQNGSAFKRALIYMVTKGASEKDLSEQRADSLSIDPQLNSLSTSFQTQFTMRVERSEDVSHAQPSTPSARSQARQGAIVSNASIRAHSPSRQPTPVQHGTPSRSSRQGSARHSDDSQDHEYAAAASGPPPVYIYQHVRNLAGIVKTLLGPCTDSTPALSLGHQADAYLQAHGLSGTLEEFIEKLAPKGMPIKEIKYLWCLCGPSDRIQSLEIYHVMLLPMCFALRSSENGPARLLSKARKVSTTKVRFPWRSSAGRKSVKRTPAEKAVRAEKRQERRVTVHQALSAAHAHIREEAEKLHAELGGHNVDWYIQQLMQDARSSRAKRAPNRWNAYLSAELKRFNAALPSGQTAYKSNNLPPEIKAKWDAMSPEERITITDPLLKNLQDQRETKQLAVQNVPINAFHDVRSNLASVQEQLEALHARTGTEILMIAVRSSNDHYNRPHVFFMSDRLSDFFTVVLRTQLADVAMQMESYCLSGIQGLVSRSRDQVAELKARINKMIYDKLRAAAEVEVPRMYYTNFEKKITEKHAVVIEGWPLGKFCSPSDLRSRTELEVLYKAWETGETRFRKMSRAEYETWDDSRFRAALENGHDNDELPVPVTAVSLRAPNGTSIEDLSTVHSSPSPITVSADSNTFANEAGGARVVPDGVPTHSQALLGSPAVTSTVVTSTAVTSTASTTRKRPANAAANSSNKRRKQGPFQDFVNVVSGVGGELVAVTKKPRATRKDKGVPRKKKAKGPANDENGMPSSGNAPANIVPAHALPSATAVTMNSALSSGDTHVISTAAVYASPSAMATTNTTPVSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H641</accession>
    <name>A0A401H641_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1701450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620733.1">
        <property type="nucleotide sequence ID" value="XM_027764932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H641"/>
    <dbReference type="FunCoup" id="A0A401H641">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H641"/>
    <dbReference type="GeneID" id="38786737"/>
    <dbReference type="InParanoid" id="A0A401H641"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000805">
        <property type="entry name" value="Hexokinase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000009">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="14">
        <location>
            <begin position="42"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="15">
        <location>
            <begin position="244"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE89820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="495" mass="54619" checksum="90C84AAEAAEA4541" modified="2019-05-08" version="1">MASRRGSGSVTLPTGQTLAFHTRSSEDEDLPHATKKKMADHLRKYESLFTLTPQRMRMIVEAFKESLELGLSKNGQIVPMIPTYVFGWPTGKETGDFLAVDLGGTNLRVCLVTLEGEGKFEITQSKYRLTEEQKQEDGQKLFDFCAECLKAFIDSNIDGGAIKKDCVLPLGFTFSYPCLQDRIDHGKLIRWTKGFGALNTEGHDVAEMFTRSLGTYNVPAEIVALTCDTTGTLIASHYVNPKTRIACIFGTGCNAAYMERVGDIPKIKHLGIAPDAEMAINCEWGAFDSFEHENLPRTKYDSIIDETSNKPGEQSFEKLISGRYLGEILRLIICELIDEGVLFLGQNTYKLEIPYSFDTAFLSLMESDPTDELLMIIGIFTHFFAVETTLAERQFFRALAKLVGRRAARLSACGIAAIVSKMGYLEEGCAVGADGSLYNKYPGFAERIHEGLADIFGEKGRNIITYHAEDGSGIGSAIVAAMTKARKDAGIYPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H735</accession>
    <name>A0A401H735_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1901050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621169.1">
        <property type="nucleotide sequence ID" value="XM_027765368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H735"/>
    <dbReference type="GeneID" id="38787173"/>
    <dbReference type="InParanoid" id="A0A401H735"/>
    <dbReference type="OrthoDB" id="2804661at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="811" mass="89974" checksum="00CD1F502CCEF0F3" modified="2019-05-08" version="1">MTTGIAEYQLLENALDSSSTFTEVNSAVVDDVAMRASPKFEGRSFSFQHPHFMPSFILYSETPPLPGYWFSRMDIPNSATFRHRALHEEERCAGTASKMEVDEEKSLISSGELAIGAVNREASFIPSEEPASSTNTEPHVQDEKDKATPLIGFDVIDTFSSGRVSTWSSLRRGLFSPPHESTRVFFRKTHRRKGAGPDLRGSARTPGKEFDQPSSEPRTQQATVSFDSVTLSQNFQQGPEFYSRFSYSQQFRLVKMETRPLRSDSDLNSKNAETNNGKDALSPAGNASDRDGFIFPSRGVFPSWEGLGELLHQVVPTDRSSQAQHEGASYLSRLSSARSSKKPSGSQLGACALTKFPSWHGLDNGVQVLKELGDGHTAMGYNFLYRDDAEGQSPPAAISPTPTIPDWRGSIHSSHNSLSHGDFPVHHAEVTGEFPGQIVTPTLQQPGVHLIADEDCCCLRGPHAIDYEADNNSNDADAPNAVPVHTPVPMEYQASLAAINNDTPDNRHRYVPEAELVDDLWDDRERRRKIRLGKWRHASQIPTEEDVLAEPDSYPFTEEIDRILTPHIHVLSALLNSPEEVDSTSVPVLQYLRSDAGSDGAKSVQSPGNKSLGKPTKTSEVDSRFRQHPAVRSGMVPHTGDLDIVEQARINNWFYLKVPASRKRDHFTQVPEFRSIGSAADQTAFILSQAWAYQVAMAHGPHEAKDVDQEALELLEGRMFEISQAAGRAGYYQWGLDAGHHQDDWEPYKDLRSMWNHYDAEFSESELQTGPEYTAFEAPPPPAEAMSLIPAKRRPVPVPAYRGAKAAKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H755</accession>
    <name>A0A401H755_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1603380</name>
        <name evidence="3" type="ORF">SCP_1901040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620587.1">
        <property type="nucleotide sequence ID" value="XM_027764786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H755"/>
    <dbReference type="GeneID" id="38786591"/>
    <dbReference type="InParanoid" id="A0A401H755"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="25998" checksum="88B240F2169FB88A" modified="2019-05-08" version="1">MPTESSRTAGSTSSKETSIARAACRLLSRSCSCMGAATFTVSLLAPRLFLPTDTVVKPGLGYRGKASMGERLEAVWRVEEGRAEDPGRAKPVGALQGPHSPSDSSKVKSLPRDISNTTPALRDHADAEAALDASAGGVGPRHTARRRNYVERGRWLAGSAVPTRRKKVPHTCRAQPPWLIGKCPEVTSAAVSNQSPRSGEKSSGVLRGKWPSQRILARDAVLGTMPSESLHPLCCDQRQTRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H780</accession>
    <name>A0A401H780_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1400080</name>
        <name evidence="8" type="ORF">SCP_2000170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000020">
        <property type="protein sequence ID" value="GBE90274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619517.1">
        <property type="nucleotide sequence ID" value="XM_027763716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H780"/>
    <dbReference type="FunCoup" id="A0A401H780">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H780"/>
    <dbReference type="GeneID" id="38785521"/>
    <dbReference type="InParanoid" id="A0A401H780"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE90274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="147" mass="16443" checksum="654FDA2A64B66E5E" modified="2019-05-08" version="1">MPTRFSNTRKHRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNFDKYHPGYFGKVGMRHFHLTRNLQWRPIINVDKLWTLVPEEEKQGLSEDSEVVPVIDTLQHGYGKVLGNGKLPKLPFIVKARFVSAKAEAKIKEAGGVVKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4S9</accession>
    <name>A0A401G4S9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative AC transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0100600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608101.1">
        <property type="nucleotide sequence ID" value="XM_027752300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4S9"/>
    <dbReference type="STRING" id="139825.A0A401G4S9"/>
    <dbReference type="GeneID" id="38774105"/>
    <dbReference type="InParanoid" id="A0A401G4S9"/>
    <dbReference type="OrthoDB" id="3252425at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="519" mass="58951" checksum="3EDD4EA77D640129" modified="2019-05-08" version="1">MPKHRGTPSAPDRRLRPKDVEPPKRDHRACVEDADDDDDVEPPKCNRRAHIEDADDDNDVVEIFESDNEATEKVRAKKKELVTPEEELSEMQKDWTATAYAFYKPEVTIETDKVGMKVKRWLDKGDRTSMGNMHRHIRKCWGEEALAAADEMNTAADAHPSVEKFRWSEDITAAFERKGKGKITYSACQHTCTETRAEIVHWVSESLRPFTIVEDRAYQSLMKTGRPEYWIPLRWTVARDVHKVFACCRARIAKMLQEYDGELSFATDAWTSLNHKAIVMFTVHLQHKGVPLRMVLDVVKVADSHSGINLATAFAKMVDDFKIAIKMLGITADNASPNDIIIDELTELIESFQGQANRARCFDHIINLMAKGLLHQFDVPQNEADAALDDAENALHELAKDLELGVGEGGEEREPLDDIEGLQDEREGMSMEDRAVLDASVQPVKLVLVMLRKIASAIIHSSTKLLPAWLKVLADLELAERKMPWDVVTQWNSTFRMLEFALKYWLAVDEMTGDRAMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4V6</accession>
    <name>A0A401G4V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608114.1">
        <property type="nucleotide sequence ID" value="XM_027752313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4V6"/>
    <dbReference type="STRING" id="139825.A0A401G4V6"/>
    <dbReference type="GeneID" id="38774118"/>
    <dbReference type="InParanoid" id="A0A401G4V6"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="108"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="33291" checksum="718A166A09A76114" modified="2019-05-08" version="1">MRSARKWCIVDAGSNAVITAREFGKMVLIIPRVVPDFSSPLGGELVISFPDGYGCETFSVPLNPTSDVLKNWKIIENSLWGTIIDGYICQSLPPSTLSPSTILSTYFGRPVHLVMKGPQPRECAPTLGVPGLQATTLFQDGFPLLIASEESLQRLQERIHTAAVKSPEEVHIGGLDHARWRDGELPMERFRPNIVLKGAGVPFAEDMWREIVVSPDRALDPASAPPQQTITLVSKCTRCLLPNVDIATGVRDAAVPFKVLMKFRTGKDPARMNQSCFGCNAVYGGEGVLHVGDWVRVKTWAGGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4X2</accession>
    <name>A0A401G4X2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0100460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608087.1">
        <property type="nucleotide sequence ID" value="XM_027752286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4X2"/>
    <dbReference type="STRING" id="139825.A0A401G4X2"/>
    <dbReference type="GeneID" id="38774091"/>
    <dbReference type="InParanoid" id="A0A401G4X2"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="651" mass="72497" checksum="B2E01E90F340E599" modified="2019-05-08" version="1">MALPLKSMDFLVTRHDVANDKPCYIDKLSNDILVDEVFKYLDAFDILRLRQVSRLYYYLTHHSAIWKRLLRTIDVPIPPFPPSANYSLEKLTGFEVERAVVRAVSLERDWKKEKPAYRMWWSFCAHHEVLSMVMLPGGRYLIASVSDKKRTRYSIVLFAMDSVLAGAFALAKTNTITEAYNLQARYMTIQGERGIVISYVRKRCKKRTKKSASSSEHGVDKEEPSIKYHECISLHVQLSSLDILVDSRLEPGSEEFIEFAKAQPPPFQMLAMVRASAPLGVPSLDNIFGSPYLAIPQGNNKIVFKNLNGGAGSTLNCGPTAVAPIEKHTILAIRLVPAGNKILVARRICPDNAEPLLSVEYFNVIISGKVSTEVHQFNTDQMFSFDANAEIAQISDHGIPPREDDSVMGDLYDCPEVCTPRPISVYFTLKSGPILLRLTLFPKRKTDAPPASSPKGSPTSPTSPTQTLSHARTYGAYKYPLPELRILSYLSWDCHGMEVRVLPGSYRAIAYLVKKGKDGDVPSVSHCFRYYDPASRSADAAANVDELDAAAVEAVVNGLQPPKREIVKQFRIPRRALKSVRALAWDENIGRLCIASGDGTCIQVFDFAHASTVEHTDEGIERWPVPVHLDPNPDAILTPRPMLPTKTGLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G575</accession>
    <name>A0A401G575_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0101910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608231.1">
        <property type="nucleotide sequence ID" value="XM_027752430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G575"/>
    <dbReference type="STRING" id="139825.A0A401G575"/>
    <dbReference type="GeneID" id="38774235"/>
    <dbReference type="InParanoid" id="A0A401G575"/>
    <dbReference type="OrthoDB" id="2522283at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="220"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="417" mass="46646" checksum="D257B291FAC3DFAD" modified="2019-05-08" version="1">MGLFSLLDVLFPSPTITHDLTSDLTTTYPPRKPVLRRAKHVVHVPIEIVMNILEVAYDEDDLQANLGLFANCSQVCRDWSFLSQKLLFRQVTLHSQTAYISFQQAVERSTARGRMLGDTVVRMHVVLDHNQPYRISERSFAWAVTLCPNLRELDLALYGQGSGVQDVVCSADVPRMQRPAPAFDDHTVAILRSGPRISSLQFSNWSDNSSSLPQLLDIWPSLKSLSISGTPPKLPSGSAASFSCTLEELRMNFQTSPSADFMKWLLHNSESTLRSLRFDRMPSPDLFEYLVSEHGPTLQSLSLPACAAQESVSLQQCQALRELRIESAWSPSAVHRSLPCTLEHIAIGVDMDTSLQPVLQNIKRSGVMKSVTVHIWHGGERHPLLPSLRIACALRGVELKITRDIRTFRAMTACEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5R8</accession>
    <name>A0A401G5R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0103740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608412.1">
        <property type="nucleotide sequence ID" value="XM_027752611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5R8"/>
    <dbReference type="GeneID" id="38774416"/>
    <dbReference type="InParanoid" id="A0A401G5R8"/>
    <dbReference type="OrthoDB" id="3270558at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="797" mass="88598" checksum="45EFBC9DB861CFA6" modified="2019-05-08" version="1">MDCRGRSRDISPIAFARSSHDRPIRAQISVNFVPQSNLLKYPPRHDASAATYQPRSPSPFTRHCRNINMACIVQPVASTSRLSSSPSPPRSASTMDSDSPKSTPPEPRTPPEFVNPLSRPLDYYDSPPSPPRTLQDQMQSAYALDNMHLAKVLLLKLQGIEVSGDDDPRIAAVADEDFSSSFVPPGGLQLDEEIQRKCRDGERRERERRLRMERAARLKACERLWEVSTRRVREERARITRKKEEEARLRRRHEIEAREREKVREARERELEQQRQKRHLRLVSSLNQRPLLCYDALPYERAPQPGSPSRQVDDDLFHYAVMPFTPSRSSSSLCSISSADDHILSLPRACRELALQHSQSIGRAIPFTDVIASMHGPLFPADEHAQSFSRRSPAQIELLESLLKVVDWEEDEQDKDKTRENLSTRDTAAERKDADRAAAKCLSPGTKAGLSTRSSSVNTITRSNSWFSFCSRSSRTSVSTALTTPSSSPLSPHKVPALLPIPAISSPLAANEVKRPSSRPPPSLSPLPAPDHPLAPIPAFPTKRSGPLSPARGRPLTRGATARRAPSTASDTTVRSDTTVRGEEVGLVRRMSQSVSNLVDLATQFQRAYVKATFFSVGVDVLSRSRSDSRGSSSSRSPSRSRARYVQDLRIPNTGGPKEGLKPEGYRALSSDVHVFMCATAERSDALRPTRSLIPLSWTGSSHIFPPYARIFSPPLSPPRSPFKPLSVLSREPRLRPVANPLLLRLQALQNICADHEVVWEGRAREGRMSAGKEKMLGVAWEGIGKSGLGWEVSAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G603</accession>
    <name>A0A401G603_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608480.1">
        <property type="nucleotide sequence ID" value="XM_027752679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G603"/>
    <dbReference type="GeneID" id="38774484"/>
    <dbReference type="InParanoid" id="A0A401G603"/>
    <dbReference type="OrthoDB" id="2685280at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="354" mass="38047" checksum="CB7F68CD2234309E" modified="2019-05-08" version="1">MLARPSLTASCQCSLARSSPGLKPVAARSNSSLASESSADGQTNSIPHRKRSIPIAGSFGNILIPEALKLGSLKNNASSRLGTRLNSARPDISWLGVDEFGGSLARRLAQAKAESRAKQPEGQASPASSAIAVNARGGSHKLNSYGTRVTADTRRQWEGATKDKVEEVHTKPSRSEARPPGARQRQADQRVHAEAVEEAKEVRGKVRKAGRDKPSHTKAPAGSMEIQTTDLDKLFGAPSAAQRSTAPRVAALELQTESPPAQRSLPTPRAKVRPTMSPSMALRVQRTLENSGGDYSRYLPQIQGLNEPEQRTPLGIAQLVMARKTEAGPRMRRNALGIVQKLIVNEPEYLLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G604</accession>
    <name>A0A401G604_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608508.1">
        <property type="nucleotide sequence ID" value="XM_027752707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G604"/>
    <dbReference type="STRING" id="139825.A0A401G604"/>
    <dbReference type="GeneID" id="38774512"/>
    <dbReference type="InParanoid" id="A0A401G604"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="82610" checksum="BE04DC8F7452C063" modified="2019-05-08" version="1">MIQHSRLCAIPVTVLENIALEATLIDPLGPPSVLVPLLLTCRYVYHSLSMHGCPHLYGRIFRSRFDSRAAFRRLGVRATYSKNLAWQLRKHCLALKRIRRGDIFDSNLKADLWVAFIMAVENDGKNIVQLEWANIGSLLHNFLVTRLWENRQDSNGWPAESALNALVIWLVWFDLDDAKLAAITPEKRKQIMDLIRPYVLTAARYPSFHAPDNHFDFPLPDELQNAFPYTLMTPHGFYPLYRQPDALIERGRRHFNLPLAISPPLIAQGAKLLYMTLSGTMLFDIPSSLPLNREHAIQLGRTHVCLTQADLVEVNAHKSVKLVDRGTWEWRAALTEEEGRLEDDGVWRRGLKGPSARWDNDWHRLTCCTNPWEIPELKGVVYTYGTLDGQWQGVIQIPDVGQYFALIRSVNFPEDFSDQNPRLSTVPVYMRLREHHCISPEVAVAYGGSPSDYDDGIRNGWFPKVSFRESHGMVRVDDETHNEVSHYETYVEGRPNSHSEDRCMSCLHRRRLEDEELQMRVHAQRRASQEAEIGDGGGRSFALRKETSAAGPPSTSASRLPSSSPMSEAAEDEEMRMAVDNALGPDVNVDELLDEVMGESDHEDGSDAEDTDVDADAYDDDDDRSDTDSVMEYMMHTCNGIQDIIVTGETLPRHGQAWHHFRFYGRVRKWDGLIAIVRVPVHYPELGVFIFRGYIVANTNFVGSWRAYTHNTHAIPLEGPFVMSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G635</accession>
    <name>A0A401G635_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0104980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608531.1">
        <property type="nucleotide sequence ID" value="XM_027752730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G635"/>
    <dbReference type="FunCoup" id="A0A401G635">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G635"/>
    <dbReference type="GeneID" id="38774535"/>
    <dbReference type="InParanoid" id="A0A401G635"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="325" mass="36541" checksum="D5591FCA263AB316" modified="2019-05-08" version="1">MSTASTSADTLPLGKYFASTDKKTRDKAIKNLTIFLSNPTRDALDKPGMTKLWKGIFYCFWMSDKPLVQQALASELAEILLKISTTTSSLAFLRGFWEATVRDWNSIDRLRIDKYYMLIRRFVNASFRLLMRTEWDQAACDEYNSILTGRSGPLCPDDARVPASLSYHLADIYVEELDKALGNSTDEPKLPVPLSFLLAPFFTLAARTPTKSTYQRIHSALLDPLFGALTSARDDDELPRPKRPRLSMPTYPNLIANACTIDPKMEGAIGRLELKKALLKHMFDIASEQDTRDSNRRKLYAIWKNNIDDDAGKGSTVDASAVDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G797</accession>
    <name>A0A401G797_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0109160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608947.1">
        <property type="nucleotide sequence ID" value="XM_027753146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G797"/>
    <dbReference type="STRING" id="139825.A0A401G797"/>
    <dbReference type="GeneID" id="38774951"/>
    <dbReference type="InParanoid" id="A0A401G797"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="554" mass="62662" checksum="9C8E303285F35AB1" modified="2019-05-08" version="1">MSKIFRQHSSVACFYCQTAITPFPHNPRSFRCPNCDCWNRYGNDGEIISEEPAMHDEKMNTRSFARRGSPRKDRLPSIYGSVLFCHTCQTNQMLLAQLLSNYLPPQDDPEYAERSETYDEYRRSVEVRYPPVCAECAPAVEEEIRRRDQMARTQALGGFLHATKRTTLQAPESQKDKDRLQREIAAWKIRGCLWLGSLACALGGYVAVVSRQGVLRLPGSFRLVIPVITPCSILWTVWDPTYASLRREQFQGRAVRQRGKRVYVVLQMMAWLSRLCTSVFIALSLYRPEWDRVQLWDDPQSTEARMYCSISIVLELFVLVTSHFTLQLQHPPKIRLMDGSEDRYQFMSPTSSQPSTRSTTPAVAIEPDLLNGLSLSSNGVMRTTTPKPKPIFGVASFPAGPSQSPSRSHPAGPSSTTPSSPLRHAPPNDSDMEIADDEFPSASDDPDAMDWSPIRPTQHPPRSDKKPVRLTIPDDGVWLRPQRFFAPEEPTGLENLFAKTIKLADDEQQCRGGASGVRRQAGRRCWPAWWALIGMLPLLPLAGFVWYSRWKGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7I9</accession>
    <name>A0A401G7I9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0109950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609026.1">
        <property type="nucleotide sequence ID" value="XM_027753225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7I9"/>
    <dbReference type="GeneID" id="38775030"/>
    <dbReference type="InParanoid" id="A0A401G7I9"/>
    <dbReference type="OrthoDB" id="3262732at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="12013" checksum="AE00A1398584F42D" modified="2019-05-08" version="1">MSNTRSTNTEKKELYSRELAEYTFRQWDSARRAMEASRDKPQGKSPPRSTPSSSVQRESGYLSRTSHGVKSIDYARRSYKPVDSNGREGCSMNRSAPFSKVHVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8J4</accession>
    <name>A0A401G8J4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0113730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609397.1">
        <property type="nucleotide sequence ID" value="XM_027753596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8J4"/>
    <dbReference type="STRING" id="139825.A0A401G8J4"/>
    <dbReference type="GeneID" id="38775401"/>
    <dbReference type="InParanoid" id="A0A401G8J4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="46"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE78484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="179" mass="20604" checksum="28A8AA750E94ADE7" modified="2019-05-08" version="1">MVRRLDAVYEGLKVGYRLFNYYGNEKGCSAGLKRDIDEGIVKREKFHPYNVQLRLVEYAHSLGIAVTVYSSFGPLGFHELNMKKALNMQPLFMHPPITTLVASHACMPSQIVLHWATQRSIAVIPKSDTVRMMRDNMCNVEVHLSEEEMQEIGEHDRGLRFNEPADQTWYKITHLVRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G997</accession>
    <name>A0A401G997_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0116190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609641.1">
        <property type="nucleotide sequence ID" value="XM_027753840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G997"/>
    <dbReference type="STRING" id="139825.A0A401G997"/>
    <dbReference type="GeneID" id="38775645"/>
    <dbReference type="InParanoid" id="A0A401G997"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="133"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="525" mass="60311" checksum="255A951C41D19109" modified="2019-05-08" version="1">MSTATRKPAPRLPRPAARYWKGKAPKGVDEAASESESEEEGAEAPQEEGDILIADVGGDDEEEQRLELGGAKVVERRAINVALRDVNISEEGRVTVAGKAEVGRTEVEVEEEEEEEEEGAKEEESSEYESESESEEEQPKVQFRPVFIPKRGRETIAEKEAMADDSEEALRKKELEAEERKKQSHDLVAESIRRELAEKEKEEQVPDVDDTDGLDSAAEFEEWRLRELARIKRDKEAELARELEREEVERRRALPEEQRLREDLEHAEQLRKEKPKGQQKFLQKYWHKGAFHQDEEILKRHDYTEATESTIDVSMLPQVMQVKNFGKRGRTKYTHLLDQDTTVASGGFGGTAPVKAGGTSTAGGGCFVCGGPHLKKDCPQNKDIPPGLRGAGTGANTALGGTRQWGVRDTKEDGRSWRDRDREEAPRADGRDRQRTDDSYIAKDKVRSRWDELERKGGDRDAGRERERDRDRDRDSYARDRRRSYSRSRSRSPRRDRQREEYTRRRRSRERSVEYDHGGKRRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9B2</accession>
    <name>A0A401G9B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0116140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609636.1">
        <property type="nucleotide sequence ID" value="XM_027753835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9B2"/>
    <dbReference type="GeneID" id="38775640"/>
    <dbReference type="InParanoid" id="A0A401G9B2"/>
    <dbReference type="OrthoDB" id="2804412at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="300" mass="33358" checksum="7CFE76EE96B2F090" modified="2019-05-08" version="1">MPPSTHASVVYAEQLSRLGYCYPLWDPEPTQFGEVLLGDVGHIFEGQFFRIFNATRGTDDRVNERGVQDGYIPLHFDQSDVHRHENYIPGPLYSTNVRRTDTGGPGETVGKEFTDACRFRCDNSQGAVLLLKESATYEELSIPRRIAYYTKRNIKNWLAFARDSLQLDLALENIISVYGCVKTADWALAAFFDGSGSAELTFRGFGAPAAAAFSVGDTCFSTSPAYNCGPLYATDDNATRRVQVNPVIDDLPDSSSTGEINRKQCIFLRYITLRRHGLFLRHIVADGSSLTGHQDDDYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Q4</accession>
    <name>A0A401G9Q4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0200600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609776.1">
        <property type="nucleotide sequence ID" value="XM_027753975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Q4"/>
    <dbReference type="FunCoup" id="A0A401G9Q4">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9Q4"/>
    <dbReference type="GeneID" id="38775780"/>
    <dbReference type="InParanoid" id="A0A401G9Q4"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="561" mass="59533" checksum="A6E34A7454801B27" modified="2019-05-08" version="1">MADISSTSSTTEDELPPPQNADTEKASATEPAHSPQRSMAQAIGLIATCTTAMVLNSSNSTAVAIALPTIGRDLNIPEYRLQWVVSAYSLSSGCLLLFLGRLADLHGRKLSFLFGAFVLGVFGLGCGFAQDEITLDVLRGFQGIGGAAVIPASLGMLAHAFPPSRIRSIAFATFAAGAPVGAAIGSIIGGVLTQLTEKTWRSVFYFMTGISALVFLGGLLTFDKDMPSTEQDKRVDWLGAFLVTAGLVMIVFVLSDGNIAPNGWKTSYIIALLIVGVLLLGVYVGWQYYLERVQDDPNAPRSWLTPPPLLRITLFSRGNGKLAAILAIAFLEYCGFMAFPFWLQLYYQDYIGLNPILTMVRLLPMFITGVLCNVAVALVVGFVPVVYLIVLGTTLTGVANVLFAVIDPAATYWAFGFPATVLIVFGADFVFPSGTLFVARVCLPHEQSVGGALFQTLTQLGGAFGLAITTIVYDATLKRVSLQDGVVINVNGTNAPAPAQLRAYKDAFFTASAFNFLGALLAIVFLRTAGVVGDSGKSGDGDPPEPEEKAPVRSESPSLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA62</accession>
    <name>A0A401GA62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0202730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609989.1">
        <property type="nucleotide sequence ID" value="XM_027754188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA62"/>
    <dbReference type="FunCoup" id="A0A401GA62">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA62"/>
    <dbReference type="GeneID" id="38775993"/>
    <dbReference type="InParanoid" id="A0A401GA62"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018812370" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="12">
        <location>
            <begin position="383"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="554" mass="57278" checksum="7123F698C2F53337" modified="2019-05-08" version="1">MFFTPLLAVAAVLASAVSALNPITSKGSFFFDAVTGDRFYVKGLAYSANYGSTQSSPIAATGSISALDPLANGQGCQRDIPYFQQLGINLIRVYQVNASLDHSACMSALNSAGVYVLLDLATPAPNDAISSTDPSWNVGLLTNFISTIEAFGSYSNILGFNVGNEVISNAGDDDAAPYIKAGVRDIKAYLKAHNYSQLVGYTATDSPNSRVALPYYLACENTTTSIDYWGVNIYEWCGNSSFTQSGYQARTEELASLGVPAFFSEYGCNQVEPRPFTEVAVLYGSEMTPVWSGGIVYEYNNQTNNYGLVDISADGQSITTTQDFTNLKNSLAGIAPANQSLSSYTPTIAEPVSCPASNSSWLVSTNLPYTPDNSVCECVVNQLSCLSTYTDATDLGTVGTMIGTVCGESSTACSAISGNGSAGVYGDLSYCAPLQQLNIALDTYYEDQSRNAQACDFGGLATVQSSGKPTAASAVASATSSCLAAGFASGIGIPSPTSVAASATTHPIVSSTSGSSGSGSKSAAGSVHDLPLTALFGVLLSVLAGAGGAAMIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAI4</accession>
    <name>A0A401GAI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0203930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610109.1">
        <property type="nucleotide sequence ID" value="XM_027754308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAI4"/>
    <dbReference type="GeneID" id="38776113"/>
    <dbReference type="InParanoid" id="A0A401GAI4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="102" mass="11379" checksum="0B12FEB540FB7916" modified="2019-05-08" version="1">MSTTRWTDFVNGATVITLVLSAISFLQVAVTTTNTVSASSSLKAAKEKLDEIDEIIKALNPEDHDKIEKLQPRLLVETRAEVNMLRKKVEKLQADLYSAKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB82</accession>
    <name>A0A401GB82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0205910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610306.1">
        <property type="nucleotide sequence ID" value="XM_027754505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB82"/>
    <dbReference type="GeneID" id="38776310"/>
    <dbReference type="InParanoid" id="A0A401GB82"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="193" mass="21345" checksum="FD461241B6F27CB1" modified="2019-05-08" version="1">MSSTSKIDALADRDVDTTDTELRYMAYAARLRTAVRAGHRYIAYTSDVGEAFRPVVPPVVVSAAYGISWLYLAGDVSYESYKAHRKGPSPLEAAHFSEPTRIGMVAVKRAVFQSIASMALPAFTIHTAVKQAKKMFVNTRSPRVKAWGPTATGLAIVPILPYLFDKPVEHATDYAFEWIEKQMVEGDSKTQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBC1</accession>
    <name>A0A401GBC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0206640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610377.1">
        <property type="nucleotide sequence ID" value="XM_027754576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBC1"/>
    <dbReference type="GeneID" id="38776381"/>
    <dbReference type="InParanoid" id="A0A401GBC1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="89" mass="10103" checksum="ECC70945456077CD" modified="2019-05-08" version="1">MLHTDIPIVPVRPPRSDPRPCSLPLPVRTLGLHHLRSLHRFVAIANVDTPFVAYQIVYALPRAIQAPQMILRRYQDVDALQLALQFALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBF0</accession>
    <name>A0A401GBF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0207160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610429.1">
        <property type="nucleotide sequence ID" value="XM_027754628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBF0"/>
    <dbReference type="GeneID" id="38776433"/>
    <dbReference type="InParanoid" id="A0A401GBF0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1066" mass="117951" checksum="659109C07B5840F9" modified="2019-05-08" version="1">MGHQHVHVELWAADEEMDRALPVELSTPFTVPTQKSHPQHRESMPARFVILTEHQPILSEKLRSYDMADAKGRKTLVQSLRQKLKTQFVDTSNYDDIIVETKIREWLNNHTRHAQEKATKKRMHVSGKPNAFKVWDALERDKVTEAARALTADKGCNVSKVWRVARSAEWAKLSEEEQKVYEKKAESWRNGTLDDKTKMKLREQRMMQYLKKFAKTMWDTMGIRMAFMLAYPKEAGSLKVEMVEVNHAITNETPFGAYPGWLRAYQHLAKVFSEWAKGEYGVTETTVTVKKTPADCMRAMDKIRLMANGFPLLPSVPEGMAEAPLKVMKVQVRDFMNHHYALAKGARNCKSPWMKLNSIDDINEVIPAEMLPENFQWIDPSKMTSVPVRALLDHWQAHQEEHGPEQTMRFTQYFDKDGEAAPAKYDPLPPLDGSAQALEEGSEHEVQEALTPKKAEKAKKKGKPVRKVMGKAALKATKGKAAPGGAKGGGHKRKTKDAYDSEDDARSSQDSDRSLPDIPSMASEEDTASDEDSGDGESVIANKAKGKAVATTNGRKANNGGAPQASGSSGAKTKAKRGLQDLPLGELHRFDTEETDEAWSELEPSTKELRLELQGRAPRLTGGSTVGSTVPHLVKRRDVFLATLSVEPRYQDMLKEVKIATVPQVYRFARYDPIPWSEWSYGQRYLPPSFHAVDNFDIVKNWLGDKPWLTKYRFLHPQGVQQSALVIGMALRDLTRSQFIEEGEPTNLPDYVVNSAISFDAVEQLLRCCEIITLDMVEGNVTHAMVKPVSKPAIRGAPQGGDGLGGQEEQEGDASARTHDGAATAAKVHKAHQPAPMADKLIIPSGGDEGPSQETSGGASDDGEEDDAHLSVPSSGAERPPLPPFIPKTRKAAAKEDRPSGQAKALQGRSITDALQSNIPGRITRSQRQAMDESPAKNTRSQHPLGAVKDLKKLPDPKRKRQPARPEPDGEDSSGEDNPPPRKRGRGTRDELVVASLRKKNARAEDSDDGDKPPAKRRRALPQTPEVKDKGETKLKPVRLGKAAAKVKESGQVGAGRKTRSGGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC17</accession>
    <name>A0A401GC17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0209150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610627.1">
        <property type="nucleotide sequence ID" value="XM_027754826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC17"/>
    <dbReference type="STRING" id="139825.A0A401GC17"/>
    <dbReference type="GeneID" id="38776631"/>
    <dbReference type="InParanoid" id="A0A401GC17"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="164"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="423" mass="47914" checksum="FEBB917FC4CC80E6" modified="2019-05-08" version="1">MPVAVSTGYYRFTDIFFEWHQVLPEPKDISPLKALLAYDALVHPDHPLRKAGIDGIELFLGTFPNGEMRLLFSSTQIEYIRYWLHAMRLTDAPLPIPASDYLLQSSDLTNCSPCVYRDAASLKKAIKTIEKNNRRMKGTTTLLAARRLAFEKVRTLWAARAGTWLALDFEAWDRDHTVLTEFGWSLVRWDDQHEHEQLAQRGHLVVKEHRGYTNTYVPERRDYYNFGQSEEVSKQAFKERICALVDEHSARGPLFLVFHDNSQDIKYLRSDALRAVSELEFILPDAPPARGVFVVDTADLFAALEGESSANRRALERVCIHLQIKTESLHNAGNDAHYTLLAMQSMAAGDPVDVQREKRWPNRTTSTDPKVAFEPWEEDSDYDDFEGLMPPGVPVAPAEAEVDADADADASGDANGEGTNFWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC30</accession>
    <name>A0A401GC30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0209470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610659.1">
        <property type="nucleotide sequence ID" value="XM_027754858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC30"/>
    <dbReference type="STRING" id="139825.A0A401GC30"/>
    <dbReference type="GeneID" id="38776663"/>
    <dbReference type="InParanoid" id="A0A401GC30"/>
    <dbReference type="OrthoDB" id="3217643at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="459" mass="48427" checksum="F23309ED12FE5845" modified="2019-05-08" version="1">MCYAYGSPDHATGVCPMCKWRKPIGTRCPHVREVCHNRALHPRHDVVYLKNAEVQTFNGCGFCKWANTNPPPKLSGYQNPGWPGCCRPPSASEQKCIGAADWPAVSVVHHVPIPPPIKAALDSAKAALDSAKADSAQAPTATKGNSSPSSPTGNSRNSSTQSLAPLIVRRQSYNPTRTDSMAPRSPPITIPVRARSGGSPQQPSMSLTGNASRNPDGDSFTSSLPNKSVTDQHQAQRRSAADIFGDKRSDASGGSQNSPVRRNAELGGSVSRRSIERRPSITAALPSMSVSKVTVDVPPPRRRGSVANPSPQPSVPRAERTSNLASLPRRNSVVAEPLATMSVSGSSSSSGSNSETTVISDGGFTDYLSDESEAELQRQAEAKAAILAQNQLEEQEFKAARQQLASVDLHPPKSWIGNVNSTPRSQASAPPSAAFPASYGSSPYGTAHSSVASSTHSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCB3</accession>
    <name>A0A401GCB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0209980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610710.1">
        <property type="nucleotide sequence ID" value="XM_027754909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCB3"/>
    <dbReference type="FunCoup" id="A0A401GCB3">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCB3"/>
    <dbReference type="GeneID" id="38776714"/>
    <dbReference type="InParanoid" id="A0A401GCB3"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="301" mass="33050" checksum="1CE7E92F4EF28C14" modified="2019-05-08" version="1">MASRVLLGRFSTARASSWRTLTPSRTYVAVARTFTPRAASATKGASTKTALQAAKASTTVGKGNSDNLESLSNTSDEIDVPPEELSVPAESLPSSAVLSQPPSPTPFPSEASELSDALSNGVVGETTSTDWSKSYYGLSRQPFSKDVSEVLLSPIDPQDVEMKPDGLIYLPEIKYRRVLNKAFGPGGWGLAPRSETNVGPKVVSREYALVCLGRLVAIARGEQEYFDPSGIPTATEACKSNALMRCCKDLGVASELWDPRFIREFKQKYCVEVFAENLVTKKKRKLWRRKDQPKFDYPWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCG5</accession>
    <name>A0A401GCG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0210800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610791.1">
        <property type="nucleotide sequence ID" value="XM_027754990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCG5"/>
    <dbReference type="GeneID" id="38776795"/>
    <dbReference type="InParanoid" id="A0A401GCG5"/>
    <dbReference type="OrthoDB" id="2753408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="171" mass="19527" checksum="AAFB87A9FBA00D09" modified="2019-05-08" version="1">MHELPTIHGLDRSEWPSTRYPYPSKYCPISAVNNTIDLKFSYTGVVKNKLVLMDLLDAAYSDFDRIRTILREEQVQDVHHKIEELVRSLHSAGYVHGDVRDSNILVAPRENGDMDVRLVDYDWAGMAGEAQYPPLINRKTVRRPAGAISGSAIVKEHDLEMITFMFQDLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD47</accession>
    <name>A0A401GD47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SCP_0213090</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611019.1">
        <property type="nucleotide sequence ID" value="XM_027755218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD47"/>
    <dbReference type="FunCoup" id="A0A401GD47">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GD47"/>
    <dbReference type="GeneID" id="38777023"/>
    <dbReference type="InParanoid" id="A0A401GD47"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 21" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="39"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="214"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="485"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="591"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="698"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1071"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GBE80106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1226" mass="136248" checksum="300DCAD22CBE5336" modified="2019-05-08" version="1">MPDASTRSTGSTFHTLTREKQFKNPPKKGSVVPILNEFVIPHLESFNALFDDSGLPVGDGDGQGLLSLAIKDIGERVVFDGKGEIGSESGLKGWGNRLSMCYEQVLVARPMISDKVQNDYARLFPSEARERVTSYRARMTVKLRWRVNDGPTEVEQRDCGLLPIMVRSIRCNLKGMSSADLVKHHEEPEEFGGYFIINGNERLIRYLILPRRHHVIALTRPSFANRGPSYTPYAVQIRCARQDQTSVTNTLHYLSNGSAMLRFSWRKQEYVIPIMLILKALVSASDKEIFEGVMMQDYEDTFLTDRVELLLRSFKMYSLYAGDQCLEFLGSKFRVVLSTPDDMTNKAVGAWLVQKLVLVHLDSPREKFRILLFMLRKLYALVSKSCCVDNPDSPQNQEVLLPGTLYGMIIKERLEEALHNVSQAIAADVRLSNPSVDFFDNRYFRKILARTNFDIGAKMSNFLATGNLISPTGLDLQQASGFTIVAEKLNWQRYISHFRSIHRGAFFAELKTTTVRKLLPEAWGFLCPVHTPDGSPCGLLNHLSRTCRIVTAPLAVAHIPALLAVHGMTPAFAASIDGRRNLCVQLDGRLIGWAPSAVLKQLATNLRIWKTEGKYNVPLDLEIAFVPVSKGGQYPGLYLFASRARMMRPVKYLANGHNDQIGSFEQVYMDIACTPEEIEQGVSTHVEHAPTNFLSILANLTPFSDFNQSPRNIYQCQMGKQTMGTPATALQHRTDNKLYRLQSGQTPVVRPALHNTYGMDSFPNGTNAIVAVISYTGYDMEDAMILNKSAHERGFGYGTVYKSHTVDLRETQGSAKSQTNPTLHFGLGYDVRTSGPRRHPWCDFVDPDGLPAVGTRLTAGDPLCAYIDDTKNRTIWVKYKGDEVAYVDTVRLLASDGVETELQKINITLRITRAPVIGDKFSSRHGQKGVCSQKWPAIDMPFSESGMQPDVIINPHAFPSRMTIGMLVESMAGKAGAMHGLAQDATPFQFTEEDTAVDYFGEQLLAAGYNFYGNEPMYSGITGQEFAADIYIGVVYYQRLRHMVLDKFQVRTTGPVDPLTRQPVKGRKRAGGIRFGEMERDALIAHGTSFLLQDRLMNCSDYSTAWVCRTCGSLISLGYDDISLGEMSLGPSGQLRPTGPGGEYCRVCRATAEAEDEWARKSLANAQNGISAGHSQSDLRVAIPSHNILGPASKGGNLDIVAVPYVFRYLCAELASMGIAISLEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD48</accession>
    <name>A0A401GD48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0212640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610974.1">
        <property type="nucleotide sequence ID" value="XM_027755173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD48"/>
    <dbReference type="GeneID" id="38776978"/>
    <dbReference type="InParanoid" id="A0A401GD48"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="232" mass="25289" checksum="7CE3FF035D00D4E7" modified="2019-05-08" version="1">MAQPSDACIISKYNVHDTIADVNRHLAKADGSGEDEVQKAWISELSRLVRILEDRFQVLTTFGESDFHPREVNEIHATFVDVVLYARLQSFASLHLPDPSQEEVDAAMTRLALGQDFFTALERRAAQPALIHNPGCEACQEAEATALLNKLRGTPAPAGGADDLIVHVNGFKTALYFIRERQGWVAVDVITVVNALRQAGVMILTLGVEEHDSDVDSVPGGEAEDDDGDAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDT3</accession>
    <name>A0A401GDT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611249.1">
        <property type="nucleotide sequence ID" value="XM_027755448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDT3"/>
    <dbReference type="GeneID" id="38777253"/>
    <dbReference type="InParanoid" id="A0A401GDT3"/>
    <dbReference type="OrthoDB" id="3062870at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="164" mass="18232" checksum="D0C2A8D3669424B5" modified="2019-05-08" version="1">MPSLPTFRDADSVHAEAENIELTMPSTLSVMLRARICVPGLGEMEDELRYADAMEALNNIRCQLRTRTVYSHSKMKNVKGQRLNIRAHAAQSSVNVHIRAATLRYCHELNDADVRGLGERALMNEERAEQERICELSGSSSNSFGVRHTGVVAVGEGCCMLSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE68</accession>
    <name>A0A401GE68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0301930</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611391.1">
        <property type="nucleotide sequence ID" value="XM_027755590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE68"/>
    <dbReference type="FunCoup" id="A0A401GE68">
        <property type="interactions" value="662"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GE68"/>
    <dbReference type="GeneID" id="38777395"/>
    <dbReference type="InParanoid" id="A0A401GE68"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1910:FF:000005">
        <property type="entry name" value="Cysteine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="15">
        <location>
            <begin position="33"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="16">
        <location>
            <begin position="523"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="714"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE80478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="776" mass="88059" checksum="60B95C53A0808670" modified="2019-05-08" version="1">MSARQPPWSPPTPKTEEPVLKVYNSLTRTKTEFVPSEGRHVKWYNCGPTVYDASHMGHARNYVTQDILRRIMTDYFGYDVHFVMNITDIDDKIILRARQTHLVNVFRAETTALSPTLIDQVQEAWAAYLDSKVGKGISEAERPSKGKERETWPQIVEQFNNKTWRQDGLKRDEKFEMHFFAANRAYSALLAAEESLKSGATGQDVAHTLIDESRDILAISLDKQYGSSITDHSIFRSLSSYWEGKFFEDMRRLRVRDPDTLTRVTEYVPEIVSFVAGIVQNGYGYVVDGSVYFDTRAFDKADNHHYAKLEPWSKGNKELLEEGEGALSVATGRRSGADFALWKASKPGEPSWPSPWGDGRPGWHIECSVMASAVFGDNMDIHSGGVDLAFPHHDNEMAQSEAYHECGAWVNYFLHTGHLHIEGLKMSKSLKNFITIDEILQKYTARQLRLAFLTQTWNAKVDFSESLMTGEVRNLESTLNNFFTTVRARISRAQVDGPHLDGKNQYQQAERETTNAFHHSQRAFREALCDSFNTSEALNVLRDLVSRTNVYINSRGTNLDVSVVERIARWVGQMLRMFGLGEGKPFEIGWGQEREGVEVIVNREEILMPYLRTLSSFRDGVRKLAIAKGDEALQDILALSDKLRDVDLVPLGVALDDQEDGKALVKLVSPEDLMKARDEKRVQAEAKAAKKAAAVEAERQKRLQKFERGRVPPELMFKSPNVPEGSYGSWDEAGRPLTDGKGKELSKNQGKKVQKEWALQKTLHEEFLEWQKSKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE72</accession>
    <name>A0A401GE72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611397.1">
        <property type="nucleotide sequence ID" value="XM_027755596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE72"/>
    <dbReference type="STRING" id="139825.A0A401GE72"/>
    <dbReference type="GeneID" id="38777401"/>
    <dbReference type="InParanoid" id="A0A401GE72"/>
    <dbReference type="OrthoDB" id="3171058at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="527" mass="58383" checksum="081163701BF03252" modified="2019-05-08" version="1">MSAERTLIRLSNTMSDTQCSPRADHTSLPTELWLEIFRYATYVPRARCISPRESFEIQRPFNPLNTPVSSMRTKCSLVLVCQGWRRVSTELLYEHVVINSSRRAYLLGRTLESSDLRAAIAGASTSATSENTTSERGHARWIRHLEIHTCSRTSKTAPFWYAIAGILSMLPNLHAVSGFWERPLSKGMLDVFTRYLGESVRALYWEEGEVPAGEASLLAPTFLTKYRSLRVLDIRKLAFENSKTVPELGDTPVVLPGVIDLLIPMCPAIMAFATKLSLPALARLVLDASTARTRRLSAIPPALDTLLAVHGPKLTTVELLPVNSLSYASGPVDITTFLQPDVCPQLDTLVFDCRERVLSAPVISALQQPPQRPPAKSLFSPLPPPTGPPPSDSAPPLNAPHAALRRVGIRGMGISRLYPNRPTHAQLHLRAFAEQRELFPALEVVRTLGFLVDASTDPFARDIFIWWTEKYESAGLDLQDGEGVVWLYTDPECDESAATEEQLMAADCVDYVHKSDVEQYNLAKAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEE1</accession>
    <name>A0A401GEE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0302160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611414.1">
        <property type="nucleotide sequence ID" value="XM_027755613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEE1"/>
    <dbReference type="GeneID" id="38777418"/>
    <dbReference type="InParanoid" id="A0A401GEE1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14398" checksum="CD87C7FDEF81B4E7" modified="2019-05-08" version="1">MKAEYPSRTRARGSRYKVQLDDGQKPSTRILFIIHISSHNTHYQLNLNKMMFPSTLSLAAVLAACSVAFASPAGASTTTVTFIKSINTVAYDTTTTVTATSYATSTVPRTTTFTSTTTTTTVRPTTTTTYVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEE9</accession>
    <name>A0A401GEE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611471.1">
        <property type="nucleotide sequence ID" value="XM_027755670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEE9"/>
    <dbReference type="STRING" id="139825.A0A401GEE9"/>
    <dbReference type="GeneID" id="38777475"/>
    <dbReference type="InParanoid" id="A0A401GEE9"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="42115" checksum="DF69700140BAE53E" modified="2019-05-08" version="1">MAHPNSALSDSETYWRDSQAWLKERGYLLRPRYRADWKPSWETTSKDPYHCEDSLTLRRSTIIDATRTSDGTVVALKKVSKSTHPHEAEIGQFFSNEPLRSDPQNRCIAIHAVLQDPMDQDLIVLVMPFLRIYNDPRFDTVGEAVEFFRQIFLALQFMHHNHVAHRDCMTLNIMMDPLPMYPHLYHPVRVERNRQFTGNAKRYTRTQRPTKYYLVDFGLSRKYNPDDGPPEELPILGGDKSVPEFQGEGYNVASDPFPTDIYYLGNMIRKDFLRKYHGFEFMSELVSDMVHKEPVKRPTLDQVISRFDDIRLPLSTRKLRSELVRKQDDLLLRFFKRIRHIYRTVGYVARRLPPLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEH2</accession>
    <name>A0A401GEH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0302850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611483.1">
        <property type="nucleotide sequence ID" value="XM_027755682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEH2"/>
    <dbReference type="GeneID" id="38777487"/>
    <dbReference type="InParanoid" id="A0A401GEH2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11733" checksum="53A0BEC6757DE934" modified="2019-05-08" version="1">MSPLNILDAGADIVTVGRILPSAYDKLRNKLPHERLMKGEIYQDGTLDYLEASQDKILPTEYATLHDRYITAEKARETLGAPMFLGSFQHRKEIAQWKSDVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFK1</accession>
    <name>A0A401GFK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0306890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611879.1">
        <property type="nucleotide sequence ID" value="XM_027756078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFK1"/>
    <dbReference type="GeneID" id="38777883"/>
    <dbReference type="InParanoid" id="A0A401GFK1"/>
    <dbReference type="OrthoDB" id="2815373at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="102" mass="10973" checksum="41D85A6C4A4A675F" modified="2019-05-08" version="1">MEEFRKSKISKAEASIQLLEAISYHDTAPEEEAAKRSAYAVYLAELDEIESAQREAGDRGAIQAPGPSENSAQILASSEALEPSSAVGDKRKRDASDDSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFT0</accession>
    <name>A0A401GFT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0307700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611960.1">
        <property type="nucleotide sequence ID" value="XM_027756159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFT0"/>
    <dbReference type="GeneID" id="38777964"/>
    <dbReference type="InParanoid" id="A0A401GFT0"/>
    <dbReference type="OrthoDB" id="2670565at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="553" mass="59993" checksum="F2300C384FB8EB4A" modified="2019-05-08" version="1">MGSVRHARAVHVPDLAVHAVASSPQLAAHFSTIAPPAGPGFQVKQELLDHERVPSPVDVRTGVSSSSIPPAVDKTRLVERYRVNQRSRASRAPAVWPSPPVSSGPGETDLARNSSYRKPSEGNKENRVQTIARDMATSDHASLPSTLYAPASVSQLPLHPTRTEPLNSNKEFSPLSIGKILAGMNASHSNPSTRSATGKPSGPASTSPVPSSYIILSFRGERVQCDLESLDENPTGIIAVLRATANQRVERDKWMIVGGHYRSKGMVRAAVAVIAAMVEALTSPPAGVPPDELKPAYLMLSSCHTDLAKQTRTADGGETPESASHMRKAAELLQKVYGTHMPVAKHEEEEGELECAARLASMDVSPAALARSRLANASNLPRSPDHSRERSRTQSNHVATLEREIQSLRDRQASSSASASQLRASKRKLEEDINEERRIRRRAERALDTAADDLASARRGEKGALDQCKVELEARRRAEVRVEELEAELAAFRREGREIREERRRERDSCGTIAVLLLKLAKGEEVDRRTLDAVVGGSATERGGHHSISGGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG06</accession>
    <name>A0A401GG06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0308240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612012.1">
        <property type="nucleotide sequence ID" value="XM_027756211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG06"/>
    <dbReference type="STRING" id="139825.A0A401GG06"/>
    <dbReference type="GeneID" id="38778016"/>
    <dbReference type="InParanoid" id="A0A401GG06"/>
    <dbReference type="OrthoDB" id="2421327at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="216" mass="24438" checksum="97418C4F0FA12E96" modified="2019-05-08" version="1">MPCYTAIYHPAANALAISIHEGATDAVSDNRPENTSPQPNAQGKVDYFAESESDKLSHWKKKLGETVVSLVREDFDRRGIGIWPRYEQALVVDFPKDYKLYVHKSGDRHVPRGDAYLFGSHYVHVFRSPEEFTPHLKWLMRGSPMKDGRRDCHCKYCDPSRTQTEISRELHHKKDGGGGRKGGGKRKDGTRGTKKSQFPSDIPFKDYTKLNTGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGE5</accession>
    <name>A0A401GGE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0309740</name>
        <name evidence="3" type="ORF">SCP_0309770</name>
        <name evidence="4" type="ORF">SCP_0309830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612160.1">
        <property type="nucleotide sequence ID" value="XM_027756359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGE5"/>
    <dbReference type="GeneID" id="38778164"/>
    <dbReference type="InParanoid" id="A0A401GGE5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="83" mass="9258" checksum="6FDE35F18E11B7CB" modified="2019-05-08" version="1">MDDVEDILPDVLSLAFEREGTAGAARRPPDRSRPTAVQKTAGRTILSLQERRTLAAGLEPRNIGTKHYLFLRQKGELEAAWDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGJ9</accession>
    <name>A0A401GGJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">rRNA-processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0310260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612212.1">
        <property type="nucleotide sequence ID" value="XM_027756411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGJ9"/>
    <dbReference type="FunCoup" id="A0A401GGJ9">
        <property type="interactions" value="722"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGJ9"/>
    <dbReference type="GeneID" id="38778216"/>
    <dbReference type="InParanoid" id="A0A401GGJ9"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="65"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="194" mass="22622" checksum="50BEAED7177C06DD" modified="2019-05-08" version="1">MGRAKKTRKFAAVKRMLNPNDIRLKENQLKQKKKEESEKEKAVRRVPQMASSLFLQHNEALVPPYRVLIDTNFVNFSLQNKLELISGMMDCLYAKCIPCVTDCVMAELEKLGHRYRVALRVARDPRFERLTCSHTGTYADDCLIQRVTSHKCYIVATCDRELRRRIRKIPGVPLMYIVRRRYAIERLPDQGAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGM1</accession>
    <name>A0A401GGM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0309850</name>
        <name evidence="9" type="ORF">SCP_0309880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612171.1">
        <property type="nucleotide sequence ID" value="XM_027756370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGM1"/>
    <dbReference type="STRING" id="139825.A0A401GGM1"/>
    <dbReference type="GeneID" id="38778175"/>
    <dbReference type="InParanoid" id="A0A401GGM1"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="287"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="509" mass="57918" checksum="8BA9F6A16C06B4B1" modified="2019-05-08" version="1">MDPVDHLFHPGPAYPSYRQSFPQKTNISPHADPRPAHQPVYNFYPHRPSPPHSPAPVPLFHQQPPQDSHQRDPDQPVDQIHDDPPIDEEPLYVNAKQYYRILKRRVARARIEELHRLSKQRKPYLHESRHKHAMRRPRGPGGRFLTAEEIAAQKNLQADAGPSNSTSPDADDEDAIDVDRDIDRDVDMSVDSPIEPPKPPVFDQDRREPLKPPSFQHIQPQQPVDEKDRPRAGPISQPSIQPSIQPRPQPSQVLRQLPQTQPPTQAQAQVQAQAQVQAQVQMRMHQQLQAQQQPQAQRQLQPPQMARQHSQAHLQMQPQTQTQAQQVPAHPPPPQMMRRPSQTHIQTQQQQQVSQAQLRSPQGQVRSPLQSQQQQTYEHQRQHQHQHPHQLAMSHGASPIGLLNVNVGYQHSAPVSPLPQDHQMRDHSRQLGSQHTQVSPVQQQMQDSSSQTSSPQISLRAPYAAMQMHHVPHPHAHARHHHSLIGRGEQLYHDVVPGSEYGGGTSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGP8</accession>
    <name>A0A401GGP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0310870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612273.1">
        <property type="nucleotide sequence ID" value="XM_027756472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGP8"/>
    <dbReference type="FunCoup" id="A0A401GGP8">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGP8"/>
    <dbReference type="GeneID" id="38778277"/>
    <dbReference type="InParanoid" id="A0A401GGP8"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000012">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="49"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="398" mass="42488" checksum="BA17249B246CBDF6" modified="2019-05-08" version="1">MFGRARRCLRLLAPSHRVYTRQEGRDFTVLAVESSADDTCAAIVTSDRQILSNVVVRQDSFHAPYGGIHPYVAIEAHQLNMPGAVQQALAEANMAVTGVDGIAFTRGPGIGGCLSVGSNAAKTLAAALNKPLVGVHHMQAHALTPFLTTPLESLPEYPFLTLLVSGGHTLLLLATTPTTFHTLATALDESIGRAFDKVSRMLKLQWSALGPGAALEQFCLETPDPDADAGEAIPDIPRPMPGRLAFSYTGLHSTVERYLHSRGGTVGAPTRLALARAFQEAAVGQLEDKLALGLEQCRRQGVDIRHVVVSGGVASNAFLRERLRMCLDAASSDVPISLMFPPPSLCTDNAVMIAWASMDRFLAGDTDAYSVALRVKWPIEELAMSASPPGTANDQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH32</accession>
    <name>A0A401GH32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612392.1">
        <property type="nucleotide sequence ID" value="XM_027756591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH32"/>
    <dbReference type="GeneID" id="38778396"/>
    <dbReference type="InParanoid" id="A0A401GH32"/>
    <dbReference type="OrthoDB" id="3164380at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="287" mass="31270" checksum="60462B4BE645E420" modified="2019-05-08" version="1">MASDFDVLSHFLPLDELIQVIYQGPSRFVVLSSVNEVGWTVYVGLSGPEGRWWSGRWTEKDVHKTVGTRSSSKLLETFTEHLTDKFIQGELYIGNWSFEKGAEINLTIGPNAKTPIHIPLAELSPGDAASFATKVFTDIARQAQSRKCRLHPSSYDPPAPPASKSTQASSSKSTVELSKAEAEIKQLKAELADARRSRTPPASTSTGTKKAVKRPHSPAAEKEINKLKAQLARTESEQSMPDTSKLVSIAKGARGRAAAVPPKGASLANPSRKRRKYQALEFGSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHE5</accession>
    <name>A0A401GHE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0313460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612530.1">
        <property type="nucleotide sequence ID" value="XM_027756729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHE5"/>
    <dbReference type="STRING" id="139825.A0A401GHE5"/>
    <dbReference type="GeneID" id="38778534"/>
    <dbReference type="InParanoid" id="A0A401GHE5"/>
    <dbReference type="OrthoDB" id="2757744at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="110"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="247" mass="27452" checksum="D1C4925029649575" modified="2019-05-08" version="1">MLEAMAYHAVGYGGDTGRRYTVSAICACRHGGTPDNVENHILSQLRDLATTWLSHLLFMVKVNGSHTKRHDDTPSVIATPTLDDTTTELTQGASNSRSEKFKLQRDGYRCVVSGAPDITFPDYPEDRIHEVVFTQACHIIRRAVAEFDPPESANKESQYLSALTTFDILRNYASVPIANIADFHEALDDPSNGITMNFAAHRGFDTFAWCLKATEVPNKYNVVYYRGPHGLHGKPSEIAFSDHSAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI17</accession>
    <name>A0A401GI17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0402140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612753.1">
        <property type="nucleotide sequence ID" value="XM_027756952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI17"/>
    <dbReference type="STRING" id="139825.A0A401GI17"/>
    <dbReference type="GeneID" id="38778757"/>
    <dbReference type="InParanoid" id="A0A401GI17"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="8">
        <location>
            <begin position="379"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="486" mass="54011" checksum="4CE30B5FE4C008EE" modified="2019-05-08" version="1">MTGTRLQPYELEPLMPGGAQNGLKEDGGRPRNAYSRALKVSAVAVVSVIGLAAALSCWSPRAQCPVARRLPTVDSETGVGRLPVLGYNTWNAYHCDINESLILETAQLLKSLGLADVGYKYVNIDDCYSEKNRTATGDIVENKARFPSGMRTLTNQIHDLGLKAGIYSDSGWFTCQLYPGSFQNELRDTRLFQEEWGFDLLKYDNCAIPFDTVIKQGMVGKFQRIADALSKLAATTRKPPMVLSLCQWGEEQPWLWAKRFGQSWRTTGDIDPNWGSVTKILDANSFITWASDFYGHNDMDILEVGNGLTYEEAKSHFTAWAFMKSPLLIGTHLASATDETLEILKNTEILAINQDPVVGTSISPFRWGINPDWVSNSTHPAQYWSGESQNGTVFMLLNTLDEPADMSFSLTESPWIRAGRQYSVRDLWTHTDNGTAVRNFTAHAVPAHGVVALLLRDAGDEPEGIYPPCARQAWCMSKNGTKYFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIG7</accession>
    <name>A0A401GIG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0402970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612836.1">
        <property type="nucleotide sequence ID" value="XM_027757035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIG7"/>
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        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIG7"/>
    <dbReference type="GeneID" id="38778840"/>
    <dbReference type="InParanoid" id="A0A401GIG7"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="187"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="28735" checksum="E4992CDD60A04E87" modified="2019-05-08" version="1">MSSRHDYRRRDRSWERDDRDRYRERARDRDRGRYRDAPVPRRSRSRSPPRRGDRPKDRDVRDRDRRGPDRRDHGRNDRSERDRRDAKGRDDRDQRDVKDVREARREYIPKARETEREAARNRDKDARLPHEQDGPSEEKLAVGEPDARDSRSAPPGSEESPNSHSREDSTVPPEEGEEDEVMDATNDDDVAMMAMLGMSGFGSTKGKHVEGNQEGSVQIKKMRTWRQYMNRRGGFNRPLDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIV1</accession>
    <name>A0A401GIV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="8">1.4.1.13</ecNumber>
            <ecNumber evidence="20">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">SCP_0404310</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="26">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="26">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="8"/>
    <dbReference type="EC" id="1.4.1.14" evidence="20"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612966.1">
        <property type="nucleotide sequence ID" value="XM_027757165.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GIV1">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIV1"/>
    <dbReference type="GeneID" id="38778970"/>
    <dbReference type="InParanoid" id="A0A401GIV1"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19 26" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0288">FMN</keyword>
    <keyword evidence="18" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="14" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="17 26" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="28">
        <location>
            <begin position="53"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="29">
        <location>
            <begin position="1666"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="1589"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="25">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1181"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1187"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="1192"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="GBE82053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2145" mass="235692" checksum="1B24003256FD9B63" modified="2019-05-08" version="1">MAIADSATISPATSAENNTQNGFHAVQRDPNSWDSTLPASQGLYDNSYEKDSCGVGFICHIKGEQSHKIVSDARQLLCAMTHRGATGADSRDGDGAGVMTGIPHLFFKREAERDLGCELPDVGRYAVGNVFFKANDPVGLQKQQSVFSKIAGELGLRVLGWREVPTDGTILGPAAASKEPAILQPFVVLRSHYGDGATCRGGPFDATHFESQLYVLRKHATHSITLSKGFYVCSLSSKNIVYKGQLSPPQVYNYYHDLNHVLYCSHFTLVHSRFSTNTFPSWDRAQPMRWAAHNGEINTIRGNKNWMRAREGVLSSTLFGEQLDLLYPIIESGGSDSAAFDNVLELLVVNGVLTLPEAIMMLIPEAWQGNENMEPGKRAFYNWAACLQEPWDGPALFAFSDGRYCGANLDRNGLRPCRYVVSNEDIIVCASEVGAVYIPPEKVISKGRLKPGRMLLVDTEEGRIVDDKELKRNTANKQNFASWIETHVLHVPNIVKRVKRVHPIEIDVDDYTLSTDPKLLAFGYTVEQLNLLILPMVTEGKEALGSMGNDAPLACISTQPRVIYDYFRQLFAQVTNPPIDPIREDIVMSLNAYVGPEGNLLEMKPEQCHRILLHSPILTVEEMNAMKNLKYAYSSWPSQTIDITFPKEQGLPGYRLALERVCSEATQAIDDGMKVIILSDRQTGPNRVPLSALVACGGVHHHLVSQKKRAKVAMMIETGEAREVHHLCVLLGYGADAICPWLAIEVIHKVEREGLVKNNKTFEDLLHNYRHSVDNGILKVMSKMGISTLQSYKGAQIFEALGLHTEIIESCFTGTASRVQGATFDLLAMDAFEMHERGWPSRETIIPPGMPESGEYHWRSGGEAHINDPTAIAHLQDAVREKNQRAYDAYAKNSNDQTRAVQLRGLLDFRYESATPIPIEQVEPWNEIVRRFVTGAMSYGSISMEAHSTLAIAMNRLGGKSNTGEGGEDAERSQLLPNGDSMRSAIKQVASGRFGVTSNYLADADELQIKMAQGAKPGEGGELPGHKVSGSIARTRHSTAGVGLISPPPHHDIYSIEDLKQLIYDLKCSNPRARVSVKLVSEVGVGIVASGVAKAKADHILISGHDGGTGASRWTGIKNAGLPWELGLAETHQTLVLNDLRGRVTVQTDGQVRTGRDVAIACLLGAEEWGFATTPLIAMGCIMMRKCHLNTCPVGIATQDPQLRAKFAGQPEQVINFFYYIAEDLRSYMAKLGFRTINEMVGRADMLKVDEKLRTRKTAHLDLSAILKPAWQMRPGAATYRVRAQDHKLYIRLDNKFIDESEPALTKGLPVHIDCDVTNTDRALGTSLSYKVSKLYGEEGLPKDTIHISMRGSAGQSLGAFLAPGITIELEGDANDYVGKGLSGGRLIVYPPKASTFKAEENIIVGNVCLYGATSGEAFVRGVAAERFAVRNSGAFAVVEGTGDHGCEYMTGGRVVVLGSTGRNFAAGMSGGIAYVLDTAHTFASKVNLEMVELGKVTDPREIAELRGLIEDHRHYTGSEVADRVLHDFHHLLPLFVRVMPGDYKRVLEEQAAKLKEEKLRQNVIDLVPSRTASQVDLASEGLEDILLPKEPPSWHGSRSTSRGRLEPSVTDMEDSLVDDATTKQRLNKLDKTRGFMKYKRLTEAYRPPRKRVKDWKEISTRLTEGELKYQSARCMDCGVPFCQSDTGCPVSNIIPKWNDLVFKDQWQDALNRLLLTNNFPEFTGRVCPAPCEGACVLGINEQPVGIKSIECAIIDKGFEMGWMAPNPPKIRTGRKIAIVGSGPSGLACADQLNKAGHSVTVYDRNDRMGGLLMYGIPNMKLDKAVVQRRLDLMTAEGVTFVPNVHVGKDLDVNDLRAENDAVVICTGATWPRDLKIPNREVDGIHFAMEYLQLNTKSLLDSELQNGNYINAKGKDVIVIGGGDTGNDCIGTSMRHGAKSVTNFELLPKPPAGRGRDNPWPQWPRIFRTDYGHTEVAAHFGNDPREYCISTKDFVIDEEGKLMGLNTVRVEWTKDSGGRWKMEEVPGSEKFFPAQLVFLALGFLGPESEAIKALGVKQDARSNIQTPNKQYSTNVEGVFAAGDCRRGQSLIVWGINEGRGAAAEVDAWLSGGKTRLPADGGIKQRVFIPPASTLTSDTQVVEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ03</accession>
    <name>A0A401GJ03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0404640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612998.1">
        <property type="nucleotide sequence ID" value="XM_027757197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ03"/>
    <dbReference type="GeneID" id="38779002"/>
    <dbReference type="InParanoid" id="A0A401GJ03"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF85">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="312" mass="35218" checksum="CA0311036CAAE7CC" modified="2019-05-08" version="1">MAECLGPETLCDSAVDHSFRALMATERTRSFTKVDLTPRRYHGYAVILFILGTLLPPLAVAARFGIGRDFFINIVLTICGYIPGHIHNFYIQNIRNNKNHQRTPKWVQKYGLVNTSEIKRKERRSQWANRYNELLPNSTLAEQPLEDGQEGGSSIDLAAEENDTRAHHNGGGDFWSRNEERYYGQNGNSDRASVRTGGSGGRWRYPANFDDTIVERPKKSASKKKKKVKKDRWARTEDAYSLQESEPPKRRRTKKKNHSTVGDAESETYSRGSSTEFPEDAEGGLYGSREPAGETSNGRADGDADDIFSHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ53</accession>
    <name>A0A401GJ53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0405150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613048.1">
        <property type="nucleotide sequence ID" value="XM_027757247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ53"/>
    <dbReference type="STRING" id="139825.A0A401GJ53"/>
    <dbReference type="GeneID" id="38779052"/>
    <dbReference type="InParanoid" id="A0A401GJ53"/>
    <dbReference type="OrthoDB" id="3268560at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="264" mass="29269" checksum="38AF6E5D48925349" modified="2019-05-08" version="1">MPHRTSFPNDVTVSGSTVSMSTLAHFLRPTFSARRAYSVFSKPGGGRYFNSAKPPKVTPSTTKGKVDSSSPSGEASVSSASKDQSSPQSNTSLTSEGTPLVEDAVSSPTPSSLNHPSINPHDLKLHQFFSLHRPLLLISQPPSSIFESSPMPFAIPCKRPQEVSSLDIFTEPPEASPEEDADAARQLSRALVMNRVTPSVSWEDALQRLGLNVREGRAEEVKMAQAEFDVWMDSTKRKRRKKMKKHKLKKRRRLNRSQIRKMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJK0</accession>
    <name>A0A401GJK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0407160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613245.1">
        <property type="nucleotide sequence ID" value="XM_027757444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJK0"/>
    <dbReference type="GeneID" id="38779249"/>
    <dbReference type="InParanoid" id="A0A401GJK0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15893" checksum="2774173CDA98BDE7" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGRDAKWPSKPAVEDAPDEEVLIFKKDGLPELITTETSPTSFGHSESIREIMADNTEHGKLPAVQNDTEPDDPPSEPPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETEIAVFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKQ2</accession>
    <name>A0A401GKQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0411360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613664.1">
        <property type="nucleotide sequence ID" value="XM_027757863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKQ2"/>
    <dbReference type="GeneID" id="38779668"/>
    <dbReference type="InParanoid" id="A0A401GKQ2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="254" mass="28028" checksum="095869145AF83639" modified="2019-05-08" version="1">MQDTDSNTAHDTNPIGEDEDDEISDVSQSDSGMVLLDDEHKEIVEEHYCNADYLNPATKITVVTMGDLVATLGEKGYSKQGDTKGNDLIVYESEREPHCGVLITSVKNALNAYGAGAGENFFIYTASRKLRTVSKNFQVFVQVPKEDAPGDENLYLGEYRVTDPGVPTHGWNKLAEKHKADVIELEVALTEQTGSAEVVDAMSIRSKYDQGLLQLSLHIFTCDGWDPDSWKCVPVPPENLRRESQAVDEYGIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL33</accession>
    <name>A0A401GL33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase subdomain-containing protein PKL/CAK/Fmp29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0412410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613767.1">
        <property type="nucleotide sequence ID" value="XM_027757966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL33"/>
    <dbReference type="STRING" id="139825.A0A401GL33"/>
    <dbReference type="GeneID" id="38779771"/>
    <dbReference type="InParanoid" id="A0A401GL33"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="535" mass="60789" checksum="D9CFF41A7F390356" modified="2019-05-08" version="1">MSDSPDGLFNYSSGRWLVNNDLRLAERRREFDVDELCRLAAQSVGRSSQDIDTFVKLAEGGFNRTFLITMHGGFEMVARIPYPVTVPKFYAIASEVATMRFLRSSGLPVPEVYDYSPSSDNAAKTEYIFMEFVRGTKLSDVWLELEEPDIVSVLRQLAQLESRMMSIPFPAGGSLYYTNDLEKAAGRTGIPLNDERFCVGPDARLHMWYGRRSQLDVDRGPYENAEAALVAAARKELAYLEQFGRPLLPFQRERREAYGYKEQSPSDHIKNLERYLLIASSLVSKNSALHHFRIRHPDLQPSNVIVSTSSDSNQLKIVGLLDWQHASILPAFLLAGIPGHLQKYDDPVSQALIPPSPPADMDELDQSEQSHAMGLYHRRLVHFHYVKNTEEYNKLHHDALSDPVSMFIYRLFDQAGAPWEGETHALKTTLIEATEIWGRLTGEGVPCPVAFEPEDLRKTKELSAKLQVADENFEGCRDMVGFETETWVSNEHYAMAMALAELLKLRVLAEIPEEEVRAKIEANWFLNDMDEKDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL83</accession>
    <name>A0A401GL83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0413120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613838.1">
        <property type="nucleotide sequence ID" value="XM_027758037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL83"/>
    <dbReference type="STRING" id="139825.A0A401GL83"/>
    <dbReference type="GeneID" id="38779842"/>
    <dbReference type="InParanoid" id="A0A401GL83"/>
    <dbReference type="OrthoDB" id="3260303at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49870" checksum="EE38ABBCBD04F8FD" modified="2019-05-08" version="1">MQSSSTSAGSSSNNSYTRSAHEPPETDILFSHRLHDDFLQEIHDITHSPTRVTQFLHDPNLLSPAHRHARKQSASNLGEQRTDNHAHPSQVHRDTANALTVVLGEEEREAHRLRRLLGEAGERLESEICRADDSEARARAAQELAKEGEARVTSEQSARRQAETDAAHAHEEVRRIEALQDAAAEDLRRAEVQVLEVRQQLEEERKRAAEAVDGVRKAQQVLREYQALEQGHEEVKRLELGRGAVDPVDERAMAFEEGRAEGYAAGRAQGYAAGRSNGFQAGQATGYDQGMKAGKAKGFSTGIRQGHAEERDYALEQFDRFLESDSGRRSLQDYLTHNSIRRRTKRPHQTEVRPGQFRLYLEPVSNSSSEAVRGRNATAEVLVERVPAQELLAASQEQSTPLGKQRSRESLKERIRNTVHGRRHSHQHAHDHDREPVPSLYNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLL1</accession>
    <name>A0A401GLL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0501110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613978.1">
        <property type="nucleotide sequence ID" value="XM_027758177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLL1"/>
    <dbReference type="STRING" id="139825.A0A401GLL1"/>
    <dbReference type="GeneID" id="38779982"/>
    <dbReference type="InParanoid" id="A0A401GLL1"/>
    <dbReference type="OrthoDB" id="498286at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="288" mass="32985" checksum="650EAD96DF534847" modified="2019-05-08" version="1">MVLTPGDIPLGTGPPTREELLIYYPAKFTWKQLKTFVNSGDLRLLQRDKKLHLRFSEYMKGIQAQYGSTVNYLLTKRLRWGEPDRQSRLCSLLDEDHSVLDGLDSDCNETSTELPPISADAPHHFTADTPPELISIIMNDWPYSVPPEVEHILIWTRLPLLRPSIPPSIASHLLEYGLWGFTGNTEPPPSPSTLPECLPALADWNFTPDNIVHPPPRTEKEEALLRETIDEISEFVRRKWKEAEWETAWFVNPSRWQSVPGLAHIHVLAKHKPSEEINSSDKISRKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLM2</accession>
    <name>A0A401GLM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dual specificity phosphatase ibp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0501220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613989.1">
        <property type="nucleotide sequence ID" value="XM_027758188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLM2"/>
    <dbReference type="FunCoup" id="A0A401GLM2">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLM2"/>
    <dbReference type="GeneID" id="38779993"/>
    <dbReference type="InParanoid" id="A0A401GLM2"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="137" mass="15545" checksum="D5DEF898D855F590" modified="2019-05-08" version="1">MAKYISPDELATIMKSDKVPMKDFCVVDVRDDDWQGGNIKGSHNSPSHGFLTRLDDLVAQTKDIPMVIFHCTLSQVRGPKAASIYAETRDLLEAEGEDKAHDVRILQGGFQDFQAKYKDDPELVENWKHDVWGELHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM13</accession>
    <name>A0A401GM13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0503090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614174.1">
        <property type="nucleotide sequence ID" value="XM_027758373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM13"/>
    <dbReference type="FunCoup" id="A0A401GM13">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="38780178"/>
    <dbReference type="InParanoid" id="A0A401GM13"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="27"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="288" mass="32007" checksum="F03B93A992DDF78D" modified="2019-05-08" version="1">MGLSEKAKGKQRAVEPANEPEAKALSKDLTIRFTEGIPDLMLAVAEKDTVRDVKTNIRASRPQLEKRRLKLILSGQLLTDSALLYTRIVVLEERQRRAASGGQPNVVSLEPSPAASTWLHCSVGPPIADEEEAEEESKIQTAQLKPLRGFDRLAAAGFSAQDIANFRLQFHAHSAVDYLDQEFEDDEEFDEHARALEERWIESMDGGTASQSANASSAMLNGIGIGFFFPLIPFFYFRPPKPAVFWDNGVEHEVMGSSIFSRRMQIGVILGFIVNLIFGTWIYLLTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM88</accession>
    <name>A0A401GM88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2OGFeDO JBP1/TET oxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0503380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614203.1">
        <property type="nucleotide sequence ID" value="XM_027758402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM88"/>
    <dbReference type="GeneID" id="38780207"/>
    <dbReference type="InParanoid" id="A0A401GM88"/>
    <dbReference type="OrthoDB" id="3200752at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="221" mass="24566" checksum="06986D7722CD4F34" modified="2019-05-08" version="1">MESGRLETSASLKLEGGRSWLHDIHDSSALLGAILAVVHPTLYAAGCQCLGLIQQDPELREMALNWSSPFNALQVIANWETPFHRDSKTRYMFYDLLATLGNYTCAWLNFPAMRVAIDYSPGTVIAFCGKAIRHGVTRADGERLIYAYFMREGVQNRLGILAPHWMQASYYASHIGMDIMPKTDGDENTMQGMETVDGSFVGGTKLVEVMAKCMESRISES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMQ1</accession>
    <name>A0A401GMQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614362.1">
        <property type="nucleotide sequence ID" value="XM_027758561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMQ1"/>
    <dbReference type="GeneID" id="38780366"/>
    <dbReference type="InParanoid" id="A0A401GMQ1"/>
    <dbReference type="OrthoDB" id="2392789at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="607" mass="67500" checksum="03E71E8C077A7992" modified="2019-05-08" version="1">MPPRSRPFGDLFASGRSPQLQRTASGNPPLTPRTPHTRSGRAEEGLTEVELSDLRHDSDDDDDSSGHQSQPLLSRTPFSSLAASTGYRSRGDDRDIRESGYKYVLSLVVERSPLVVGTLLLCFGLAITMLSFKKASTEIDVVQAAQPSPSRLYSQDALRPTPSAAAARFISYENYTKFPLSGPEFHHECEKLMGGFMHHSGYWVPPRMGPLDVPHHDDDVSNGGRGRVCRASITYMLDGQVGLAADLALMAQVAGIARQRNRTFLVDDTYWNRGKWTNHFEEVRKLQPGPEPGCRAPPPEELVACPRTARHWVVNSRTAKYHLGHPYSEEYEDPYSLGINRVKPIFERGLHSFLETIRPNAQNMALIQAARSEIASILDLHPVSNTSMESDNHPEKLRAHPDPYIAVHIRRGDRKAESWAFHKSYVPLEHYVTAARDAWSRLYPDIPLESPPLHFPAPPITYIASDSTDMLRDYVAAFSPSTAMFALALSTNSGLRALAPHHAYVQTEFVKEEEAERILLTRGMIVDLALLSGLWASEGDAVPGAVVCTISSNVCKISALGLGWERAFGFDDGGDYSMGAINEQRKRWVEIDNKDAVSPEWRAFDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN11</accession>
    <name>A0A401GN11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614530.1">
        <property type="nucleotide sequence ID" value="XM_027758729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN11"/>
    <dbReference type="GeneID" id="38780534"/>
    <dbReference type="InParanoid" id="A0A401GN11"/>
    <dbReference type="OrthoDB" id="2587912at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019001913" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34953" checksum="5CD7304D70FFB1A2" modified="2019-05-08" version="1">MSLFRIPVELLLEILTLALDEHLCPTDVLRVNHTISELGQHILHSNLHFRSIGQLTVFARETTPLVCPPKSLVITLAGGSASFDVFLHLADALLRCKQSIDDEERKQDKPVPLDLLSLCLHSHTRNPHQKYIYDALTLANPKTFIWTGPDPDHHFSTAVSPFYYFVAIVPAATFHLFCAIRTWTHIEHITLANLSFPSDQLGIHMPHDTPLLPVIPSLRTVCLGQATLLPPGAIAAMVCLPGQDSLERIRLVDAYRQSIWGPRLRRGDVERAAIALGVGDPHTVVEKVRRLVVCEAKNERIMGGDRVEGLTILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GND6</accession>
    <name>A0A401GND6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0507820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614639.1">
        <property type="nucleotide sequence ID" value="XM_027758838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GND6"/>
    <dbReference type="GeneID" id="38780643"/>
    <dbReference type="InParanoid" id="A0A401GND6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="91" mass="10435" checksum="E7687B55312BD98B" modified="2019-05-08" version="1">MAAHRSGQVNSDDKPTLPVAHAVLNQKVFGDERSALVHRQPPNKYYVMQTHQSDNRRKEKPVLNVVNDEELCEEKKPSDRRFKLVHGSETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNR2</accession>
    <name>A0A401GNR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614780.1">
        <property type="nucleotide sequence ID" value="XM_027758979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNR2"/>
    <dbReference type="GeneID" id="38780784"/>
    <dbReference type="InParanoid" id="A0A401GNR2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="91" mass="9989" checksum="89B5C92FF0004089" modified="2019-05-08" version="1">MYASDVHSEPIFNGLSFQCILAAAAALEAPALPQVDRVADRGDEDGWVVDSLRSRQPRCSQKVVESDPFYNNGVWDKEKPLIFSSVHVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNW6</accession>
    <name>A0A401GNW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614826.1">
        <property type="nucleotide sequence ID" value="XM_027759025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNW6"/>
    <dbReference type="STRING" id="139825.A0A401GNW6"/>
    <dbReference type="GeneID" id="38780830"/>
    <dbReference type="InParanoid" id="A0A401GNW6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="85" mass="9205" checksum="8E62397E281BAF72" modified="2019-05-08" version="1">MPQSPSSPLVLTPMPAHRKSSSQKLGQDSRGGSCKHISMQSLVPTSRRASQQQVREREREGECDAGLSLHPYAMVPSPGGYRAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP56</accession>
    <name>A0A401GP56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614842.1">
        <property type="nucleotide sequence ID" value="XM_027759041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP56"/>
    <dbReference type="GeneID" id="38780846"/>
    <dbReference type="InParanoid" id="A0A401GP56"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8481" checksum="67847038632B9AD0" modified="2019-05-08" version="1">MQTLLLYNIPNILTGNVKIVDRYHVMYGQVGKIDDRAGLTTDPATGELLYTVVFNEGQANEERLKFLRPQVEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPA9</accession>
    <name>A0A401GPA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0510590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE84000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614913.1">
        <property type="nucleotide sequence ID" value="XM_027759112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPA9"/>
    <dbReference type="GeneID" id="38780917"/>
    <dbReference type="InParanoid" id="A0A401GPA9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="9601" checksum="F36D7C674B332855" modified="2019-05-08" version="1">MGACSKALTEGTLVMGPLLAVTCSGDGQPSDLWQWAHPSYYTLGDGPTAQQYSYGGGPTAQHITYGGGPTAQNNTYGGGPTAQKYPYGGGPITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPG6</accession>
    <name>A0A401GPG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615026.1">
        <property type="nucleotide sequence ID" value="XM_027759225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPG6"/>
    <dbReference type="GeneID" id="38781030"/>
    <dbReference type="InParanoid" id="A0A401GPG6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19433" checksum="36C6E8B078FFC6E1" modified="2019-05-08" version="1">MATEDGIPQGTLWRIAYTVLIWAVDGIDFTSELLWPRTEQELETKPSRSDHWSDDEIMRRRVNNEYKERSHYNMGGHSIRRISEDVITKNIWTDPVVRVHEEKTDPPAEALALQLVASSTTIPVPSREPHWLHCGRISPCGPSSKSHGQSDATSSSSGVFAAPARSFLANLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPU3</accession>
    <name>A0A401GPU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0602160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615151.1">
        <property type="nucleotide sequence ID" value="XM_027759350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPU3"/>
    <dbReference type="STRING" id="139825.A0A401GPU3"/>
    <dbReference type="GeneID" id="38781155"/>
    <dbReference type="InParanoid" id="A0A401GPU3"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="506" mass="58233" checksum="65C2032F6E411A4A" modified="2019-05-08" version="1">MASPFFFIGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGALIFTKMDLRSGYNNVRIKDGDQWKGAFKTNHGLFEPMVMFFGLCNSPATFQMMMNALFKDMINEGWIVIYMDDILIFSNDLEEHHVQTRRVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTCTAAGSPPFEWTTELLLLPDKAKPFIVESDASKFATSAVLRQADINGDLHPCAYISQTLNPAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNCRQARWSLKLSQFDLHLIHVPGTQMIQSDALSRRNGLDDSESDNEDRILLPNALFVRSISPTLFDEIRNHAAKDLIVHEALEAIAHKGPFPMKSSLSDWEVHDGVILYKGKIYVPPSKTLRRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVEGCAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQV6</accession>
    <name>A0A401GQV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0605820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615516.1">
        <property type="nucleotide sequence ID" value="XM_027759715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQV6"/>
    <dbReference type="GeneID" id="38781520"/>
    <dbReference type="InParanoid" id="A0A401GQV6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="195" mass="22720" checksum="04E50FAD8B89EE4F" modified="2019-05-08" version="1">MPARFVILTEHQPILSEKLRSHDMADVKGRKTLVQSLRQKLKTQFVDASNYDDIIVETWLNNHVHHAQEKATKKRMHVSGKPNAFKVWDALERDKVTEAARALAAEKGCNVSKVWRVARSAKWAKLSEEEQKVYEEKAESWRNGTLDDKTKMKLREQRMMQYLKKFAKTMWDTMGIHMAFMLAYPKEAGSLKVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS27</accession>
    <name>A0A401GS27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0702020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615929.1">
        <property type="nucleotide sequence ID" value="XM_027760128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS27"/>
    <dbReference type="GeneID" id="38781933"/>
    <dbReference type="InParanoid" id="A0A401GS27"/>
    <dbReference type="OrthoDB" id="2847449at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="147" mass="17251" checksum="811DE0CC1D1698F9" modified="2019-05-08" version="1">MSNDDKEIPNSMYWIHPLKEDNWMPWKRCMTAFVDEKKLLGYVTGEIQKPEPSANPNIRETRDAEIQKWGKKDQRVRNLIIKCLDDAQVIHTEGVMTAHHMWDLLHTVKEPKGQHGIIALSRVFYDYHADEGVNILKHVAKLREIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSS7</accession>
    <name>A0A401GSS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0704690</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616195.1">
        <property type="nucleotide sequence ID" value="XM_027760394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSS7"/>
    <dbReference type="FunCoup" id="A0A401GSS7">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSS7"/>
    <dbReference type="GeneID" id="38782199"/>
    <dbReference type="InParanoid" id="A0A401GSS7"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E1_dh"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="638"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE85282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1004" mass="112857" checksum="C67C9A557F2C1506" modified="2019-05-08" version="1">MLSKHALRRVPYAVRGSRFRSVGPQLLHRTLATLAVPPSPNDPFANGTNAYYVEEMFRHWREDPKSVHVSWDVYFSGMENGLPSSQAFQPPPNLVPAPADGAPALHAAGGAELDDHLKVQLLVRAYQVRGHHVADLDPLGILDADLNDVHPPELELSRYGFTERDLEKQIALGPGILPHFATEDRKTMSLGEIIKLCKRIYCGAIGIQYIHIPDKEQCDWIRERIEIPKPWNYTVEEKRMVLDRLIWSESFEKFMASKYPNEKRFGLEGCEALIPGMKALIDRSVEHGVKHVTIGMPHRGRLNVLANVVRKPIEAILNEFSGTADDDDSPAGDVKYHLGANYVRPTPSGKKVSLSLVANPSHLEAEDPVVLGKTRALQHFEQDEATHVTAMGVLLHGDAAFAGQGVVYETTGFHNLPNYGTGGTIHLIVNNQIGFTTDPRFARSTPYPSDIAKAIDAPIFHVNGDNVEALNFVCQLAADWRAKWKKDVVVDIVCYRRHGHNETDQPSFTQPRMYKAIEKQPTPLTQYTKFLVGRGTFTEKDIEEHKKWVWGMLEKAASGAKDYVPTSKEWLSASWQGFPSPKQLAEENLPTRPTGTTEEVLKRIGHVISSFPDGFTPHKNLARILSNRGKSVEEGRNIDWATAEALAFGSLALEKIHIRVSGQDVERGTFSQRHAVVHDQENEQQYVPLNDLGSNQARFVVCNSSLSEFGALGFELGYSLVSPDALTIWEAQFGDFANNAQCIIDQFIASGERKWLQRTGLVMSLPHGFDGQGPEHSSGRLERFLQLCDDHPHVYPTPEKIERQHQDCNMQIVYPTTPANYFHVLRRQIHRDFRKPLVVFFSKSLLRHPKARSDLSEMVGETQFQRYLPDPHPECLVSPEQIRRHILCTGQVYHTLLQERDDKNISDVAISRLEQISPFPYDLLTPHLDKYPNADILWCQEEPLNNGAWTYAGPRILTAANETQHHKGKYPLYAGRDPSSSVATGSKAMHKKQIELFLATAFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSU6</accession>
    <name>A0A401GSU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septation initiation network scaffold protein cdc11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0704260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616152.1">
        <property type="nucleotide sequence ID" value="XM_027760351.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSU6"/>
    <dbReference type="GeneID" id="38782156"/>
    <dbReference type="InParanoid" id="A0A401GSU6"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="526"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="659"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1376"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1533"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="271"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="931"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1417"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1538"/>
            <end position="1555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1577" mass="170989" checksum="01E758E44F653237" modified="2019-05-08" version="1">MDDALMSARPAWQTDELEDEWIDQDEADDSVARNSSYNCTTSDLSLTQPIGSVLARNDDLETSSPVSSSGGTFLVREDVPAAPLLPQTPGRNKKGMVKDFFSPLALEKMFEPPSPPSSTPAPLPSSQSSVPPVPSRLSQVYIPGEDEAEHLEDESEGISRDQWQDSGAISQGLAVSVSPSSGAPLNCQFTFEMPRRSPFDPMTSVPEAQSTPGAPNLGSSAWNAPLTDPRLRLFQFQYDTFTREHLSAMVDSIAVNTPSGGSGQSADAASPTSLSPVREVSTSRLRSIKRIKLSPASDYSDRGDGAAVIMRPLTLRRDYVGESKSLMEKIRQARDFSTVSTVATARSPDSQGKNSPALDTPNATSKTMARPSGVSDADVSRAPSTTGTASTSNRGTYSSLAYREQAANLMAQIKRDMKGSKRIFSGDTELSHMTLSNDNEEKSAPSAPCMEITQLPMPGRNGKENVPEEKPNSRVVSSRSPRSNKSASPRKHLRRPSCIRNVEQQLADQVSNVSLDSQDLLEQFPAPPVGVTVTTVPTAPSSPADTRNVRSDPGFLAPPSEDGPAYPSSSVRSGRNEDLTRFVSSSTASGTTLTTGSAASFVKHPGPKQITRITPDDVPTLPNRVGKMVFDKVMMRWVKDTALAVTGPAEDHEIEIPAEVEANDSEDPFRDIESLGEEEPRPVVERDELDDQGSVDFQQSRIDEVETESEVEDEEEVELTSFSFDEPSSELVQAMAGEEPDPDDTDSEDEDTTAMRGPSDDESDDSDDVYGDPVLNSNGHASEHAIQDSNVLPCHIPSSVRTPTPPARASAGLTPTPVIRSAMKSNSITPMSAMKNNSGNRTPANRLAHRRSVSFSDGKRDGPILGIGRNAPSPDITVEDDSPLASGSNKSAAILVPSARTRRIADMLDNLEDLSMGDESPSKTSSAGKTPADELHPIEPRRPSSIPSNVGGAGRGISRRVVSRSQPLKSPRSSSRSANGTFLTECSFGVAHDRLVQVITDVQPFEPYWEELTSIDLSKKNVDSIARLKEFLPRLDSLSVNGNQLSWLSGVPGTVRSLSVASNSLTGITSFSHLLNLESLDISRNHIDSLRQLECLRHLRELRADGNKIDSIDGLQKMDGLVKLSLQGNVLRAIDFKRCHWARLEMLNLSQNRLVEVAGLVSLPAMVALNLDNNSLAELEFDGTLPRLRILRVSGNRLQRLNAPPFPNLRTLYADNNMLGTITKAYRLTKLENLSLRNQSGRTGLSLSIYDVRDVKRLYLSGNPLDTNFLTEPCYNLVYLEAAACRLTALPAELARLIPNVRVLNLNYNFLADARPLAGLTRLRKLSLIGSRIAQARQLVRILHGMHDLEMIDFRMNPCTLGWYLPLLVRDVPGALQPSDERNHGRSAGIGNNEAQNPREDCQPARGVRGESPPPQGSSSPARRAHSPGADAEAEADASVVAPPTWKDLDAKFRRDLPDAAYVGRLAYRGLVMRACARIRMLDGVEVGEKEREKAEQLLRGVLSARQGRKLVAGEGEERRECGGAEGVGVLGKLQKQGARETGREGRGEPARDAIADVLGTRERLRLSAPGLGVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTB7</accession>
    <name>A0A401GTB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0706590</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616385.1">
        <property type="nucleotide sequence ID" value="XM_027760584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTB7"/>
    <dbReference type="FunCoup" id="A0A401GTB7">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTB7"/>
    <dbReference type="GeneID" id="38782389"/>
    <dbReference type="InParanoid" id="A0A401GTB7"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="18" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="16">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="15">
        <location>
            <begin position="260"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="17">
        <location>
            <begin position="367"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="17">
        <location>
            <begin position="516"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE85472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="931" mass="103373" checksum="19ACA9713469DD92" modified="2019-05-08" version="1">MALRLSANHLHPSESGSESDGHSSSSQEEDEDLTWEDWVSDSVDNRPCRSLFDQDKTFTTVAEALNHDRLVYGVDVEDITARLFLDSYQRIRLINWIRKEKPAPAEVVALRGDEPFLCSDEYLIPALEDDPLLQVQSGHWSEEEWEEDVEAVGPPTDLAGALRRIAALEKKLQQARQDLSDYREFVGQRLNLAGMSEALKEPAASSSTRLAVPLRDDDSHYFQSYAENDIHAVMIQDKVRTATYAKFIQSSPELFKDAVVLDVGCGSGILSLFAARAGAKRVISVEASHIAEKAERIVKDNGLEDTITVVQAKVEDITLPDGIEQVDVIISEWMGYALLYESMLDSVLRARDRFLRPGGVMAPSQCKMMFALCEAGEIFKERVGFWSDVYGFDLSAMGRDVYEDAIVDIVGPETIYSEAYTIKDLYLGDVISRQLDFSTPFTLVSTAERRTKIHAFVLYFDVFFTATGEPIPPDTDVYLAREGDPLLAEVWPLGGRAHTARRLSMGEPLKGKGRPKVTSFSTGPASVSTHWKQTLFLLREPMTVSEGTTVQGTFKCRKSATNSRELDVEIHYVVQEPSEAAAVGDAVVQMFKIALSAFHHVVLPALQSVRRLWQGRAAGHRWQPGDRQNDRDGLRVQWCQGSRRCTYRRALRKTATELDALGPGRCVALPADLQELEEVERLVRARRGAARPREQRGSTMDAYPVGCFALSPGAGRSLMAGRWTLDVWRTTRRSRSCSRSTRSGCSRSRRRVFPSSALRAAAVFKHPARIYQRGCAKHARRRFFLIQLVCVGSVNGLWVTRLETYAYSALHHPSWHFAGRGSGWGGHHAQHHRVRSALPCVPSSHPAAARPPSFRRVREQDDGAHAGELIKRSTPLQRIGAPEDVAGAALFLASRAGRRVAGRDAGHAGDLRAPKLQAPARGATSPIYGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTE7</accession>
    <name>A0A401GTE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Microtubule integrity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0706470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616373.1">
        <property type="nucleotide sequence ID" value="XM_027760572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTE7"/>
    <dbReference type="FunCoup" id="A0A401GTE7">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTE7"/>
    <dbReference type="GeneID" id="38782377"/>
    <dbReference type="InParanoid" id="A0A401GTE7"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EB1 C-terminal" evidence="11">
        <location>
            <begin position="124"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE85460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="212" mass="23878" checksum="49A33445567A481B" modified="2019-05-08" version="1">MDSVYGDVPMSRVKMNAKHEYEFIANFKILQNVFRAHKVDKPIPVEKLVKCKMQDNLEFMQWCKRYWDTNYGGQGYDPVARRKGAPADPPATIAPLAPSSSRSGSSLNVGGARPRGRTPVGGRAGSTQPNEVQNLQTQLREMSGHLEGLEKERDFYFSKLRDIEIIVGQQLETLEAEGKDDPLLRDVQKILYSTEEGFEVPEPGTVDEEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTJ4</accession>
    <name>A0A401GTJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0800270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616423.1">
        <property type="nucleotide sequence ID" value="XM_027760622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTJ4"/>
    <dbReference type="GeneID" id="38782427"/>
    <dbReference type="InParanoid" id="A0A401GTJ4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="62" mass="6533" checksum="90704C656C55A650" modified="2019-05-08" version="1">MGDFFICQARSTRLEGGAGFVTLAEVGVTGLPSKPGEARGQSDEPSLEDQDIADLRLSSMCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTR9</accession>
    <name>A0A401GTR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0800900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616486.1">
        <property type="nucleotide sequence ID" value="XM_027760685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTR9"/>
    <dbReference type="GeneID" id="38782490"/>
    <dbReference type="InParanoid" id="A0A401GTR9"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="34"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="680" mass="75692" checksum="962789ED90EA646F" modified="2019-05-08" version="1">MSSPTEEQKPDTKTDNVDNLGTPTYTDAQIAKAWETCAKGLNEYDTKRVATWKEEIDTLLVFAGLFASVLTAFNIESYQLLQSNPSADATVLLLAQISTQLSSFSVSAGFVNSTQPPLPPTAVAGLEAPLISASSIRINSLWFSSLICSLSAASMGILVKQWLHQYLSDMSVSRRGVMQFRREGLAEWRVAIIVMVLPMLLQAALWLFLANLLELLWTLHRTVAIVATGFVTILAALQLTSTILPAFVSKCPYRSPHALAFYALVGLFYPFVEQFYPFVEQFYPFVEQFYAFVFHFTSLDLPNIIRHIFALVTPVSFLINRMGMVIRQLIPRTIDYNWRFRDNATIAESVARNMLDVSMLAAADRAFEEDEFIKNVIRPCIQSMPDVHYAERIFFDVVKQCSHGSSDGSFTDVVDRSADALADIALDIATDEGLSRLSVEQSSQFLSVLNYALGNTTRSQHLHHVAVAFLNNADVKIRDLAFNIIHPIRNHVVVSDRDLQAIVSYGDALKVDDNFGRFRFLQVIDLLLQCTSSDHVSETHLSTAQTGLMQTLHKFFEKPEMFIAELCMMLKIGWKFQRLIMRNSGFGDGGLREAVTGLFSQYETDDRFSRPSDKDSLKELLAKLREPGERNDTLDMHAPPGPGLLEPDVEGCPSSEGAASNGEGPSRSTKDSVEGMGSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU06</accession>
    <name>A0A401GU06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616583.1">
        <property type="nucleotide sequence ID" value="XM_027760782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU06"/>
    <dbReference type="GeneID" id="38782587"/>
    <dbReference type="InParanoid" id="A0A401GU06"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="273" mass="29535" checksum="C422E2B5A8DAF66C" modified="2019-05-08" version="1">MPIIHPSPNPVPPTPPLAIDMGGSYALPTRDLLPAAVIIAENPENRGTAVRRKDKDVKTKDGVGGRPRRFPGKRLFRGDDDSPPLVKKRGSGAFASRSTHLPRRTPTLHWPLRRRSSAPALKEQKVTHAVIPGAPFDAEPDAVPFHNEQDACPSDAPEEDWVTGRMKTNAENPEEQPPKTPQMNTTGVFPQSMRSSRGSVTATPRTAVTPESVKSKLSEMSSTVSGKMVSALGLKLKSRQTEKSSGAAEQDCGSLGDKRDGERCQEKEKKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU49</accession>
    <name>A0A401GU49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0802830</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with PEX6; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616674.1">
        <property type="nucleotide sequence ID" value="XM_027760873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU49"/>
    <dbReference type="FunCoup" id="A0A401GU49">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GU49"/>
    <dbReference type="GeneID" id="38782678"/>
    <dbReference type="InParanoid" id="A0A401GU49"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000105">
        <property type="entry name" value="PeRoXisome assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="447"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="732"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="200"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE85761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1055" mass="114076" checksum="EF7BF5BE4D85A66C" modified="2019-05-08" version="1">MPRRARIHFVSLHSSLVNLPISLYGPLVERGIRPQGLAVHLTLTSASPKAASDDAKKRTEAYVGWTGMAASSSLAHFNSGDTSDRGLETIEIDPQYADGLGFALGDIVEIGLLHNLSYATSVATEPVSSDDWEIIELHASHVESTLLSQVRVANIGQEIDVWVLGRTRVRLNVVYLEPSTSGKALLLTTSTEVSIAPKLRRKAGASGSRGGPTAINGSSGSTKVNGINGGINGVSKLKQGNDVPHKDAGKKRRQTRTLRVLPQRIFPPSSPVDSEVAIAYVSRAVLASLDEEPQAVKRVKSWRAVVRRVRPPADPTQEQAGHGPSALAAPAPRVLVPNADGVNGRPPSPAQNDEVVVVWSPEVTIPGGHIVFHGIVDGVDDWDLVRVTFLREEGDIPDTPSHPPGEEEYKMRPSQHGLAGVDDILSRCSTFCLTNFALHAFSKRVRGVPGLLVTGRSGSGKTSILHAIAKSLQEDSKTFAYIHYVDFAKYSEIPITKVRALLKYWMDKASWHRPSVLVFDNVDKLMGAELEHADSFRSRHITEIFLAIYGPSARSAAPNANGVVLLAAAESQAALHPLLNSAHAFQEVVGLKPPGKDARRDIIGRLVRDRMETSDITEEPSVPLNFTALATQTEGYSVTDLKDLVARAVHRAAIRASRNDADENAATTLVPGDFAAAQVDFVPLSLRDVKLQKSEVAWSDIGGLAETKRILRETLEWPSKYGPIFAQSPLRLRSGLLLYGYPGCGKTLLASAVAKECGVNFISIKGPELLNKYIGASEKSVRDLFERASAAKPCVLFFDEFDSIAPKRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDSALLRPGRLDKSLLCNMPDASERKDILTALRRKTTIAPSVDFDALAAQTDGFSGADLQALVYNAHLEVIHETIAASESLAQSGGAGPAEEERAIEYVRLGVLGEDGGKGVVTRAEEAAFQRRLRRILSNQATGKRVANHPAEVDAPKKHEISEEHLRRVLKTMRPSVLPEERLRLDHIYRAFVSDRSGELPVPPDAGGVGHRVSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU68</accession>
    <name>A0A401GU68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0704610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616187.1">
        <property type="nucleotide sequence ID" value="XM_027760386.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GU68"/>
    <dbReference type="GeneID" id="38782191"/>
    <dbReference type="InParanoid" id="A0A401GU68"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="9">
        <location>
            <begin position="764"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="509"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="822"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="871"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1237"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1309"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1475"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1520"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="876"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1246"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1271"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1317"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1351"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1369"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1383"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1402"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1532"/>
            <end position="1542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2973" mass="331699" checksum="CDCC8E0C88378E2C" modified="2019-05-08" version="1">MASLSPDLGGSHSRTCVACKRLRPLHAFSLAKKGVNKGNLSATCTECSERKSRTQKTKYKEQNEEKKGSMLSTVAFTDFLAVLESGNGCINIEAEVDTRSLGEDVKDGKTIANTVAKLVWEVTGYRWPYHSKWNVAAGCIKFRYYCAQSETRQKQSKKSAPTPDKQRDKESMMSFNCRGWLSITTTEGSSVVSVQLVHDDDHIPYCSIDIPNDVEAFVAKNASMTPTQLWKEIIDKYPDAQFTKKAIYQMWSEADSKNWKRDGNELKSAKILLEEGCKNSSGLYTVQPVPIASPPGLTTIAFSLPNILRQWGGRIRELAMDSTWNTNGSRFELFTILGEAYGSGLPLGYLLVQSSADAEQGAKQDVLEQFLHQLRSQWNLRIIITLSDKDWSEINALRRIFPDAKHQLCFWHALRAIKTRLSILRRMPAHYDIEEAHREFTFIDVDFLPVSQRQPSSTQYQPRKTALPQLQFRINGVLQPLVPQEHRLMLRLPRRPTIRSKDVVHVEIASGSGTSSEEEDNSGSDAAAEQSLQQHHHSNVMEDIGEDIGDGADSGDIRDDVNGKSDEDETDAEDAPDWVFDMGEKKSADPTYVFCPAPHRKALLHLFTKHFCQHPLFIERDGKSHTSEQIRRDAVYEMYLFCQIRGLTEVWAYMWTSWYSHRRWHLWARSTTPWISRARTTMNTENHFKQVKHDFLPHLLRPRLDQLIWILSTKVVPAYMKRAQELEDTYRIGRSKKLTSYQIRFKKAWRTLEKKPISNSGIDYHVNVATWTCGCGNQKYNAYHLCKHLVQAVVKPPPRFFRQVVRRRTIPIYCHPDLRPKMLEGQDVTPEPAEASDGSITDGDDHLWLGNKEKLKGGSWREMTQRSVAESILGKCSREEAMSEGDARDAAEQKHESIETSDLQSGAEDAEDEHSEIDSDEVQGILERGHHTQEVLAELSKIVASQVDYKNIFWLRRFVGDNFAQHAERLLGDIRHVESTGRRRDVTWPRNRNRWVNCISYPPRARATSFRCFFSKTMSKEDWYSSHGGRYHQNCNSPEASVGRVAADSVQQAHRLLAVYPFASATPSVHVARHLSNLTISAAPPSYMQTHAHAYNTQASQYAQAPFSSLTEYTNELRHISGPYIPVNDGGYWENTHNEAIRYMGEQGSEYFHYQLPPAQQYPYSSTYQSTPFAQSIFQHSAPSAAYPTPPPPSISTSSSSLAYALVEPPRKPPKPVHRAEESGRFFNNFLAQTTAELEGPTLVQRDGKSTPYRSREPPREGESPDPLAIGSSSPQVSIPFQTPRKRKDVTFMESPTVKRIHRVEVLVPSPSTLRKSSTPSATTTPTSKRKLQAYVDVPPLSKVYFTPTSGRRERQDSQSKGKGKAMIDDDLGGFGSDEEYPPTSQSSVRRSDSVKQSGRRTTGERDDRAPLEKLTTLLEDIFEAEDALPPDASPHDLPSDFFSPHTVDGAHSLLHPVIIRKLTSHIAKVARPSKRLRLSSRDGSAIGGTPRAKGRMTDVDTNALSRILKILDRTVKSGEDVEPFGSAGEPTAKTSSQASAKKSSKSSKKHAEDNARRSKSKTPKISSDEQVSDDENASMSADERPVSQDVTEVDLDKLTKVLDTARDSVLAADCCIALLASDRLTKQLYSEELITTCLSSVKNQLNKVVYAFVEASAEVHGRTPLLRYVLRSPRESVHRRQLAEIFQAISSVIPRINNLITADSMAMSESIIIQAVYIAIGPFFVLDENDGRGKKENVVLNTLGSSAMRGLRLDALSLIRSVFANHEDQRAWIIEEILSSLIKLSDTKQKAGQFRLRDGRSIRTVSALLLQLVQTSAHDVRTEARRLNRLREEVLAVRHQDLSQNKHIDALLDERDMEEIRMYVSGLDSAMKAAKTIILFLTQRSGKSKVTKNSNEAEYRVIFDNLISDLLSVLFWPEWPAASLILSIICKFMVSSLDDVKTSQTDNNAMKQMALDHLGVIAARLRSSMLKFKQHVGASSHGSLPSLDELLSTTDMEQLQKLMSAHQELSSNLCKRSSEDQAFDSARELTAVIWGQELALALQQCGSMLGDSGEDEIDPKADRSKLLPFALKVKNALRDVWEGSVSDVFDSGSSHEEVARIDCLSEEIGTNQSLRNSFHPILNVVLQALDAPPVFMRTKALKALGQIVTSDPSILSAPNVRRAIEGHLLDSSPAVRDAAVELIGKYMIDSPKFAADYYQKIADRMADTGLGVRKRVIKLLKSFYSVTDDRSRCIDICTRLVLRMLDEDDTVKDLAIKTVEELWFQVPASIPTTQRARIGLPSVPAALDRSQLLCKVAVIMGVAGHFKDRQSPLEDMLHQIITDKEGQEASALHGKYAEICEALIDGLVDASDLPDFTVVNCIRTIHLFTSAYPAVLSGSNASTLLPYLKNSATPEEQVTSDYLLRIFRASIPHMPKTMAKFGQELQLALQPMILKPSTAAGLQGLQETVACMCATVQNITHDFGRLVALLRSCNARLQQAIAKPASQSMTAVEQRSLSILLFIASLLCEHCDFDRLRVERDNLGPEIDSITKGSIIEYVYGSLLKLYDKYGDAGLRGRILQCLGFLFRAQPALMTSDGSASIMDAIFASPTEEARGRLLKILQEFLVSEAAKHAAKEKTNTKGKTVPGKVNMEELVGNTDGFADSGVSSAVVQRYLDPILQAALSPNAQIQAAAVDILSFTIKQGLAHPLQSFPVIVALETSPNHALSTRANALHAILHSKHTSLLNARFVVSARASFDYRKKLCGGQVQGYRMLPSPTALLQRWYGLVREKRTMRQDFLKALVKVFDVEMSKSTQDDVEFVRYMAENFGTFEYKTQEEVLTVMKYLTAVLSTTGMQLVETLSPSDLLAQLHGPAQDGTEVQPAGGRAPAAVANLALMRSSVIVAMIMLLKAHLKGLYGISEEKCSKWVVGKKSAVGDRPATRKHERGVSWERLPFACAPLLTGEDGATQRRRFLEIWNEDGLTAEPEDDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUA2</accession>
    <name>A0A401GUA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0803370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616728.1">
        <property type="nucleotide sequence ID" value="XM_027760927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUA2"/>
    <dbReference type="GeneID" id="38782732"/>
    <dbReference type="InParanoid" id="A0A401GUA2"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19794" checksum="5AA7FCEC6E34CBB5" modified="2019-05-08" version="1">MSTSADNTSNSNAYRIPLLKEDNWLPWKRRVEAILNDKGLQEYVTRKTLKPQPSNEPANRAVREAEISAWGEKDLKAQNVIVLSLGDSQMVHIAGAETARAMWEQLRTVKEQRGQHGILALCRRFYRMQAKEEDNISSHITQLRQIQEQLHLMGKVVSDKDFRLILATSLPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUD2</accession>
    <name>A0A401GUD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ketimine reductase mu-crystallin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0803530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616744.1">
        <property type="nucleotide sequence ID" value="XM_027760943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUD2"/>
    <dbReference type="FunCoup" id="A0A401GUD2">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUD2"/>
    <dbReference type="GeneID" id="38782748"/>
    <dbReference type="InParanoid" id="A0A401GUD2"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="383" mass="40574" checksum="4B7A7C78EF409E4E" modified="2019-05-08" version="1">MSLLVLSASDVARVTSRFHPDDLVDLMAQVFHSLSQSHKWTSSGISQPHRVALPMENHTSLFMPSRMASVGTTIKVVSVPTSAAPQAVKERGLPASTLVLDENSGRVKAIVNAGRLTALRNASGSLLSARLLNSPASPPQVLLTVGAGAQISAHVSLFLSSYPTIHKCILINRSLSSRFSALSLALREKFPNVEFEVGILPSVPNATAESQQREVVDMEKAVKNANIIITATGSTTPFFPSAYVSPGTHLCLIGSYTPAMHEIDSDLVKRAGRVVVDSRDACLSEAGELISAGLGPSDLVELGELVNYTQSSERGAATITRSWVPLDEKIDAVRKSGDITIFKSVGVGIQDVAIACAVVALAEKEDIGVLVPDYDETDGTIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUQ4</accession>
    <name>A0A401GUQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616832.1">
        <property type="nucleotide sequence ID" value="XM_027761031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUQ4"/>
    <dbReference type="STRING" id="139825.A0A401GUQ4"/>
    <dbReference type="GeneID" id="38782836"/>
    <dbReference type="InParanoid" id="A0A401GUQ4"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="49679" checksum="BA6EEF90EE0CA0AC" modified="2019-05-08" version="1">MELRLLVETSEQSRKPSIIVDGRQWALTEPLDIHSEVLPQYTCISYVWGEGRTANPVHPTSIMSDRTLPSLAAAMCNHGSTAFWIDAFCVPVQGPQRSATLESMGFIYSRAACVIAVLSSRTFAAIGMISNWNPSQAFFERAILDDLEADAWIRSAWTFQEVINSRELLIVGEDGSQKLLKGIHFLNHLGHYISKYQDANGDLIIDWQLSNIMDTSALQVLSAMDRRVWVDNKNYFYSMIGVISSEPSTRSSNPTIETLSETFMGLCEAKGDYSFVYSAAERDDRPGFRWRPRCTVLPSVLSWHSSGESQPVRKDAQGIWLQKMMVLEQSPVGLAPRGGVMNWLHGPDLQERSEAEIADRTAVALTQMGFTGSLECISTAKGLFYPQHPLSSSSALRIQIGVATSLRWTYGAPGLLAFVAADAGPTLYIPGVFVGDIPDQGCEEELLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV63</accession>
    <name>A0A401GV63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0806160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617005.1">
        <property type="nucleotide sequence ID" value="XM_027761204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV63"/>
    <dbReference type="STRING" id="139825.A0A401GV63"/>
    <dbReference type="GeneID" id="38783009"/>
    <dbReference type="InParanoid" id="A0A401GV63"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="751" mass="83276" checksum="372A620F3F6F98A1" modified="2019-05-08" version="1">MPKTLPVSNTNPSTSSSPSPHVLRRNQACHQCRRRKLKCDANRPCSTCVRSHAYAVAHAPPGANLPAHPECTFDAVSTETVQQEPQEHPKNRFERLERKINELEALLREKDKMTSEAFIPPANNPNDPLYLNSALDPILALESQMALQNAGQPLDFAQFHAGTALDNLADVASLMDTPTPPLPSSSATIASSSPSGSDSHLDMLTASWPKNLPNPDFLRHLVEAYFAFNADAGRLFHGPTFLTSLSLPPTHHDFPSTAVLHAICAVGSMYTGAVPPPPIPSYTVPADDPWPGHLKNAEHWSDTFAELQVKYARAEIEEMIYNGVKLLQVVQSQILIASWYWSNAKWSSIYTATGLSVRFLMPLGLNVCPPFHGLYNGHRPPSLIPPAKTVIEDEMRRNVFWLAYASERIHGCSHAWAILLDDLDVSQLLPVRGDQFEQGMLVLPEDRQWSHDRNVLTIHPVGQVDAFTLYIKACMMLSRVKNFNMRFRARYYVGDPAVASYSPAAYSAMAGGSHAHIDERERSQRPRDVRDTPAFVELDQLVAAFLPSFPPHLRNPLQHNTVNVHLFSACNAPHLAQILLHESHAIIGAASCISSVKILNAARRILNLLYDVCSTSYDLALLGHFANICWFMAGRILVRFLDVATQMKSEEQCTILKVELEFIRSTLSRVGERVPLAHRYGKMLQDFNVHICGEPQTQDYAEPLHLHQSTSASPDAHYGEAQPAINPALAGPRPHHRHPRASAGSVRSMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV95</accession>
    <name>A0A401GV95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0900220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617058.1">
        <property type="nucleotide sequence ID" value="XM_027761257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV95"/>
    <dbReference type="STRING" id="139825.A0A401GV95"/>
    <dbReference type="GeneID" id="38783062"/>
    <dbReference type="InParanoid" id="A0A401GV95"/>
    <dbReference type="OrthoDB" id="2801343at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="181"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="370" mass="40913" checksum="2E4FD27DC35FDED5" modified="2019-05-08" version="1">MSSTQQWPALESCLGAFLIGIIFQSVFYGVVSGLALNYFRRYRRDSGVSIWMKLLVLLAWILCFFSLIVSAHAMYFFVVKNIDDNPMAFSKAPWSVCLLMAVNAVVVVLVRFIFLYRLWRFVKAKGEWNSGWKALLLLTVLLTLVDLSGSLAVSIKLFLTPDTEELEQIKVMVEVVFAAGVSADIFLVGLLCFSLNSSRTGFESTDSLINTLILYAINSGLLPTIVAGAGLATFLVSPSPLVYMAVYNQIANLYLISLIASLNHRKVVRRQVERPFTVDFSPLEACVSAPDVPFTPTGRTDLECGMLQSADAESERALIDLDCRTRPGKFDEKVESELVLSDAKELPSTPESESSSADIGEMMIQACRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW90</accession>
    <name>A0A401GW90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0903320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617366.1">
        <property type="nucleotide sequence ID" value="XM_027761565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW90"/>
    <dbReference type="GeneID" id="38783370"/>
    <dbReference type="InParanoid" id="A0A401GW90"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46476:SF13">
        <property type="entry name" value="2, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46476">
        <property type="entry name" value="CHITINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019346444" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="130"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="409" mass="41996" checksum="2305EBB19ED1AE40" modified="2019-05-08" version="1">MFSPSFSRLAFAFSVLACAANVLAAPAGYYGSDCWESSAAPTATPTDSEEPCPSVYPSAINIPSSTVVPSSSAVSSSYGVSSSTGVSSSFGVSSSFGVSSSFGDSSSSGSASVTSSPASSPTITASSGGPHFVVYSDAWVSGQTGPPDASAIDGFNVVALSFLLTSGAADQAQAWAELTADQRSSIKSQYANAGIKLIVSAFGSTDSPTSANADPTATANTIASWVKQYDLDGVDVDYEDFQAMDDGTAVKWLVTFTQALRAQLPAGQYVITHAPVAPWFSDNSQFPGGAYLQVDQQAGDAIDWYNVQFYNQGNSVYTTCEGLLTTSASDWPNTALFQIAAAGVPLDKLVIGKPGVASDASTGFMDSATLAGCVAQAMAQGWNGGVMAWEFPNAEASWIQAVRGNAFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX54</accession>
    <name>A0A401GX54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1000430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617714.1">
        <property type="nucleotide sequence ID" value="XM_027761913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX54"/>
    <dbReference type="STRING" id="139825.A0A401GX54"/>
    <dbReference type="GeneID" id="38783718"/>
    <dbReference type="InParanoid" id="A0A401GX54"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="42297" checksum="8E0277D6708FE98E" modified="2019-05-08" version="1">MALSNIPPSHHLSSNEEVRRYAKSTKEGIYPLSESEVEWRDRYAFLERNGLQLQPRYHLEWRPSWLETGESAGYCEDSAESWNPDTMDATQLGEPFEMLSIKSVKRKWPEFAIASQLSNFATDPSNHCVPIQMLLDDPLYPHKVLMVTPYLHPFNEPELSLVHDVMDFVKQTLEGLRFLHDHNIAYRDCNSRSIMMDARSLYPQGHHPININSVRSGFDKALHYDRLHHPVKYYFANLSKARQFQPGRKPYVVYKGGEDIWLPEWSSKLPYDAFKADVYHLGSLFESAFLRADEDLQCPDLREFLEYFKFLVTAMTYRQPKERITASYALFMAEKITSLIPEEHMSMTLWKTPILRSLHRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXJ0</accession>
    <name>A0A401GXJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1001440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617813.1">
        <property type="nucleotide sequence ID" value="XM_027762012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXJ0"/>
    <dbReference type="FunCoup" id="A0A401GXJ0">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXJ0"/>
    <dbReference type="GeneID" id="38783817"/>
    <dbReference type="InParanoid" id="A0A401GXJ0"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="355" mass="38089" checksum="5D5E18E276565157" modified="2019-05-08" version="1">MSNASRTRIFLIGATGYVGGAILTRLLVHPSAKTLDITVFLRSAEKARLLEADFGVKAVVGTLAELDKLEANAAAAHAVFSCADSDDVPAIEAILRGQRKRHATTGDLPILIHTSGTGELMDNAKGLHTTDIIYNDLDAAQIETLPLTALHRPVDVIIDHADVEGYVRTHIVMPSMIYGIASGPLVAAGISNPQSVQIPNLIRASLHRRQAGMVGSGISFWPDIHIDDVADLYIVLFDAIVTNPEKVGHGREGYYFGEAGEHTWADISRAIGVALVELGISTSAEPTTFTTEELIKYFGCEAVGNYSGSNSRCRGYRGRALGWKSIHTTDDMLASIQPEMDALIANPSYKAVVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYR8</accession>
    <name>A0A401GYR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1005470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618212.1">
        <property type="nucleotide sequence ID" value="XM_027762411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYR8"/>
    <dbReference type="GeneID" id="38784216"/>
    <dbReference type="InParanoid" id="A0A401GYR8"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="42715" checksum="3472102CCBE41445" modified="2019-05-08" version="1">MPAVAVIARRLSPAAAAVGMALAVRRLTQSGVALTTIASRALKFVALLVVFLNARSWPILWHIRVFRPLIYLDARVFCLRASSAFKSARARSAIEERWWETLSPLGRKPFDEITTYNTWAGPDDCDFNIHLSNSCYAKTLDAVRFKFALVSFPAFFRSGGRMLLGGTHWDFIREIPALSRYEVRCGIAGWDGKWMYLIARYVTKPKKSSKKDKPTTLALEDADQQAQTTGPVLAAYLPSPPTTTAPTPARTRSPGPSAPSAAPAASSATTTRARVAARPEADGATVHCVAVSAMCFKLGRLTVPPAVVLACDGFGTAPQIPRGVKVLREVFKGGWRDAGAAYPGEDVEAVRAAEGERWWETALGGDIERRRVQGYAAVAGLVEGTEGARGVAVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0D8</accession>
    <name>A0A401H0D8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1200740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618762.1">
        <property type="nucleotide sequence ID" value="XM_027762961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0D8"/>
    <dbReference type="STRING" id="139825.A0A401H0D8"/>
    <dbReference type="GeneID" id="38784766"/>
    <dbReference type="InParanoid" id="A0A401H0D8"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="114"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="301"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="503" mass="53561" checksum="E89BABFE8D84FEB6" modified="2019-05-08" version="1">MSTSRTVPPPSSQEIARKLSIVRSPPKTAIVPIPVSGTESDSDSAFGSDPANAPMSTSLLSSSSQHPPLSSIAERHSASGEESEEDDDDDEGYGEGEGHRDAAGAHTRASLDETVIKTGYLWKKGERRKTWKKRWFVLRSAHLAFYKTEAEYKLLRLLDLSDIHSCTPVVLKKHANTIGLVSPTRTFYLQAESPRNVQEWVRAINDARTSLLSTSTQSSATAPVPIPSSTSGPRTQVAASQLSRSLSQSAYTTHQLTSSESDDNSPSNIGTASAPPQPLSVQSELLSSPSKYPGGVKDPSKVVLAGYLMKCASRRHNWHKRWFILSGEQLVYSRSHMDTKPHRQIPLGQILDALEYDLPHDRHTPSVGVGSPGVASPPQAAMHGDEGERAHAHTFKVVTTKRTLLLCAPSEEEEIKWLSAVRALIARRSGAGVVPGDSVVASASSGKVLASSMHPPIGEHGHGGVGVGAGGGAGGGRRKDSIARRLSVSGGTANVPAEAASER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0K6</accession>
    <name>A0A401H0K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotransferase tdiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1201830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618870.1">
        <property type="nucleotide sequence ID" value="XM_027763069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0K6"/>
    <dbReference type="STRING" id="139825.A0A401H0K6"/>
    <dbReference type="GeneID" id="38784874"/>
    <dbReference type="InParanoid" id="A0A401H0K6"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="122"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="483" mass="53260" checksum="1D5A60719A72A50C" modified="2019-05-08" version="1">MIVSASPSTNGFAAVNGTVTHSDGTSVPDSKSAANGSKALNVLPEEFYELYLSHVAKNRKPDPIRSLFPLEDLPGVISLLAGKPNSTTFPITSLQFTTRDPQSPSEDVKLELSVDDLAIALQYTATAGLPDLCEWVYGLQSYYHGRQKGEGWKVSIGAGSQDLINKAVAALVNQGDPVLVEAPVYAGVIPIFQSLDCEMIEVETDAEGICSQSIRKVLESWPASRPKPRVLYTVPYGCNPTGMTASRKRRLEVLELSREHGFLILEDDPYYFLYYGEGERPPSYFALERDQLDVGRVLRFDSLSKVISSGMRVGFLSGPEPLVRAIDKHTATANLQPSSLTQMIALKVLQCWGYDGFKKHIEEVSQFYRKQRDVFEDAMRRHLAGLAEWITPEAGMFVWFKLLLGDSNTASKTVEHDSNHIIRTKALERGVLALPGTAFLPNGATTAYVRASFSTLPPDQVDEALRRLREVILDARTSGSQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0N4</accession>
    <name>A0A401H0N4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618909.1">
        <property type="nucleotide sequence ID" value="XM_027763108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0N4"/>
    <dbReference type="STRING" id="139825.A0A401H0N4"/>
    <dbReference type="GeneID" id="38784913"/>
    <dbReference type="InParanoid" id="A0A401H0N4"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="201" mass="21382" checksum="4CCD1DFA6469441B" modified="2019-05-08" version="1">MEPSFPQPYQSQIPEFPEPASRGVPGVPGGGSAPYSPPPYTPHQAPPSSGFRLALSTESALPPPAQLGPPVAHDADGRSPIYLGSALLPNAVHPCKVGPHLSPPCRVPYGGAEREHHGRYDLLPFDPATMEWVPTSRGLIPPGRRPIEGGYEESGKLYHALADIRGMKVPGKTGEHLHACNVAFGGGEVVVHENYAILCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Q0</accession>
    <name>A0A401H0Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618896.1">
        <property type="nucleotide sequence ID" value="XM_027763095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Q0"/>
    <dbReference type="GeneID" id="38784900"/>
    <dbReference type="InParanoid" id="A0A401H0Q0"/>
    <dbReference type="OrthoDB" id="3259746at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019176814" evidence="1">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="211" mass="21107" checksum="C53B49EBBE39970D" modified="2019-05-08" version="1">MFATLITVALFSTLTIQGAQAQGLSIDTPTIAQCQAVTVTWTSTNNPPYNLVVVNSDDPCGDAIDDLGDYNGLATNWTVNVPAGMSVTFSLMDSQGDEAWSGDMVVGQSDDASCLSANSSVSSASSGSSSASVDSSAIPAAAEAKTTLYVSPSFAEPTASSHSASASSSAAVPVGAANAGTNPTNSAGYSMREYSAPIMVLSAIAAIALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0V4</accession>
    <name>A0A401H0V4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1202460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618932.1">
        <property type="nucleotide sequence ID" value="XM_027763131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0V4"/>
    <dbReference type="FunCoup" id="A0A401H0V4">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0V4"/>
    <dbReference type="GeneID" id="38784936"/>
    <dbReference type="InParanoid" id="A0A401H0V4"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="551" mass="61181" checksum="007F21A73DFADDA8" modified="2019-05-08" version="1">MTTPHVIASSSGHHSSQSSGVVGAHFRVGKKIGEGSFGVVFEGSNIQSTQPVAIKFEPRKSEAPQLRDEYRSYRTLNGTLGVPQVYYFGQEGLHNCLVIDLLGPNLEDLFDMCGRKFTIKTVCMAAKQMVTRVQSIHEKSLIYRDIKPDNFLVGVPGSKTANVIHIIDFGMAKHYRDPKTKQHIPYRERKSLSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGGLPWQGLRAATNKQKYEKIGEKKQSTLIEELCEGFPEEFAIYMNYVRKLGFEETPDYDFLRELFTKVLKTLGEPDDGVFDWNLLNGGKGWEAGHTASTLLAQAHGGATPHTPRREHRSRDHGGHRRTSRQPLQETPQSPSSPLVLAPTPAHMKSSSRRPGQDSRGGSREQISVQPLAPTSRRASQQQVRERERERERERDTGLSPHPYATAPSPGGYRATAYGRSSPVPPNSGAPPVNGNGTGAPNTNTSESFVYAQTPQGKGTDSREDTMAGVNRAEPNGFGVGAHGMSVYDREQMTRVGEQDEDHMGGRRRGFWAAFCCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H139</accession>
    <name>A0A401H139_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619058.1">
        <property type="nucleotide sequence ID" value="XM_027763257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H139"/>
    <dbReference type="STRING" id="139825.A0A401H139"/>
    <dbReference type="GeneID" id="38785062"/>
    <dbReference type="InParanoid" id="A0A401H139"/>
    <dbReference type="OrthoDB" id="2780918at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="48571" checksum="03FADEBC23792130" modified="2019-05-08" version="1">MSLSLNDDVLFLVTSFLHPLDALRLSETCRHLHLIALPQALSSIVRGTCLQLTAFCRYMLSSPQTRMHLLRAIVIVAPVGDVPNAALLADVFEQALRLRSIHMHHSDTFIEAEPRIGTALAALEDLEDVTLFDAREHVREMLPRLRSKPRKVQLLCPMEYPRLVLHLSQLSTLRHAVTLSLFNITIEDDTLVGQPAAPFVALEYLSLQYAQIPAVLFSFRNLDRVEVWLGEILGPAPDVILSPTLGTVRNVSLDASWIRTAMTEEGIVQALRVLQFVPPLMLTLKIFAYPLRPFWTCLVALSPQLRYLHLELDTMRALENGDRLFVPVSEWLYVVPPLLASLNLHCLRISVADTGFGHTVPQMRDLLWKHIGPSLRYISLKSTPHPHVDWQTRCEYSWWMVEGSGDARRLVAMSVEAGEAIHETLCSAPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H195</accession>
    <name>A0A401H195_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1300020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619101.1">
        <property type="nucleotide sequence ID" value="XM_027763300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H195"/>
    <dbReference type="GeneID" id="38785105"/>
    <dbReference type="InParanoid" id="A0A401H195"/>
    <dbReference type="OrthoDB" id="3263571at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="60"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="23477" checksum="8AC6FF4B4E8A25B5" modified="2019-05-08" version="1">MDESHHHVSQKELGFRKPEIFNGSDRSKLREFINQCKDYMAGNSHVYQENNQKIAFALSHMQGGTAGSWAQSFIKTKLIDDNFLSYGSWTEFIRDVNKAFGNENIEETARTLLHNIKQGTRTVDDYIAEFRSLVPKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYTLQFDNQWRSAQIFKRGATTTTRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Y3</accession>
    <name>A0A401H1Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase D</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rotamase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1302560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619354.1">
        <property type="nucleotide sequence ID" value="XM_027763553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1Y3"/>
    <dbReference type="STRING" id="139825.A0A401H1Y3"/>
    <dbReference type="GeneID" id="38785358"/>
    <dbReference type="InParanoid" id="A0A401H1Y3"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000022">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="182"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="328" mass="37320" checksum="56EAC46A9CE2A5BA" modified="2019-05-08" version="1">MVRPRVFFDISIGDSPIGRVIFELFNDTAPKTCENFRALCTGEKGLSPLSDRPLYYKNSIIHRSIKDFMIQGGDITKRNGMGGESIYGGSFPDEDLTRPLDAPGLLCMANKGPNTNGSQFFITLRECPHLNGKHVVFGRAIRGYDDVVAKIADVPVEEKDRPTVPVTISNCGELMLRVKVQSQEPEPAKASAASGSESEGESASQERRKHKKRRHHRSESQDSDDRARRHHRKGKSQHKKPRSKSPLSDRRSAEGEKGPPPPEEETEEQYDARLEREEKERLEEERIRELERLKKKLEETQTKNGVRFKGRGRMKFIDPELHRGHRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Z7</accession>
    <name>A0A401H1Z7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1302340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619332.1">
        <property type="nucleotide sequence ID" value="XM_027763531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1Z7"/>
    <dbReference type="GeneID" id="38785336"/>
    <dbReference type="InParanoid" id="A0A401H1Z7"/>
    <dbReference type="OrthoDB" id="2749557at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39943" checksum="49D6CB40EF1EFD32" modified="2019-05-08" version="1">MPGVIPDTKPPSKLPPELVEYIIEEAWLTCSTAERWELYSNVCRVSPDWHAILLDICLQFVIIDVPADIEGYRKLMPSRMALRDNVQTLGGGAYYSSKPSHLCLTLRNRFKRHVMRDSYGNWSDFYAMIHPFVPNCTSVHIVLADESMFEGSMSKRLFSMLSRIRNTSLYLTWAYYAEGKGTPDILLPAVTYLRIQHYPQCSCRTASEGQHEDNCLSDNLLSRFPNLRHLHLDSPFFLKYLRASPTLETVTLDAPPSRVIATREPMSSLVGWNIGAGLNRGFLKGGATSSRRRILVNTGTKEPMGWSQAQIACDAHGVVLERRCIFEDDPTNDIPDQHGLWKLGYASGFHTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2W1</accession>
    <name>A0A401H2W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619646.1">
        <property type="nucleotide sequence ID" value="XM_027763845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2W1"/>
    <dbReference type="GeneID" id="38785650"/>
    <dbReference type="InParanoid" id="A0A401H2W1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="689" mass="73397" checksum="6906EA21E1F758D7" modified="2019-05-08" version="1">MSRSSSARCGTTQRTLLAATSARFDESDVASQQAISISYGNRAIREANAARARAANARRESDEAIEPRDSRLRNPPPREFSSRAADEPPLVVIPYRPAEPPPSSFIAYADTPLHDVAPRSLPQSSTRALPTRAAASSAPAQRTVQLIHPSLPYYENRPGPSPEDVLARRGLSAPAKPTCSALGLPGGRSVDLPTPALLVHRLRRHITLFTLHDVAPCSHPPPSTRSRRARRRRQLRRSGRCSVFIREANAARARAANARWESDEAIGETPPLREFSSRAADEPPPVVIPYRPADPPPSSFIAYADTPLHDVAPCSLPQSSTRAAASSAPAQRAVQLIHPSLPYYEARPGPSPGDMLARRGLSAPAKPTCSALGLPGGRSVDLPTSPPSSVFVPYVDTRPSSHSMTSRHVVTHRHQRAPDARGGVVSSGAADGAACLFVRPMQPVLEPQMLDGNLTRRLVRRSLALTGRALSSLAYLNALPTPAAVSSPLARRTWPLPPSGGHPLDLQTPAAKKVLTVHALLIASTYHFESFRCAPEGASATYTSAVVLHAVVRTRATAMLVRIQCPSRKRLHVSPALPYYEDRPSLSPEDIRAHWPWLVCSGEADVCSTLGLPGGHSLDLPTPALIGSPTVINARGGVVNSGEADGAARLSFSSLDRFPSGGHSSDLPTAALIGVRSHPSLPSTRAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H369</accession>
    <name>A0A401H369_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1402620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619767.1">
        <property type="nucleotide sequence ID" value="XM_027763966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H369"/>
    <dbReference type="STRING" id="139825.A0A401H369"/>
    <dbReference type="GeneID" id="38785771"/>
    <dbReference type="InParanoid" id="A0A401H369"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="37778" checksum="B48DD7E4793CCFC3" modified="2019-05-08" version="1">MTHEQSKSSTANGQEHLHPIAPYPPPPSQYNGHYPPPPGAYAAQYYSFAPVADGSHDSSPPNGHPGAPFLMAYPPPPPGLVYAYAAPPPGQAPAYPPFAPGLAIPQPPRPKRKQVKMACTNCASACKRCNETRPCDRCVKYGITDTCVDGVRKERKKGVKRGPYKRKNRLGEGGDAGEASGESSVPTPAYPMPPEGYYPWYYPPPGYMQPPHDGQHPEGAQNGNGQPMVPQFYPLHPIYAPPPYGPYPGGAIPYPPPSLSPVGTMPPAPAANGRAAEQSPNDNAGENGTRVKKRSRAKNGDDSSKVKKAKAAAAAAAEPQPQNDIGRGKDLHLTGDNVAALNGHSNGNGAEVRTLIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H410</accession>
    <name>A0A401H410_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Versicolorin reductase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1501590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620065.1">
        <property type="nucleotide sequence ID" value="XM_027764264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H410"/>
    <dbReference type="FunCoup" id="A0A401H410">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H410"/>
    <dbReference type="GeneID" id="38786069"/>
    <dbReference type="InParanoid" id="A0A401H410"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="265" mass="28165" checksum="DEA4B3747A847402" modified="2019-05-08" version="1">MSTAKSSVRIAIVTGAAQGMGESIALRLAEDGLDVAVNDVPTKLEQLAAVVKQIEAKGRRAIAVPGDVRSEKDVKALVEKTVETFGSLDVMVANAGVMLLKAVLDTTTEDTDFVYSVNVNGVFWCFKYAALQMIKQGRGGRIIGASSTAGKRGQANMAAYSGSKFAVRGIIQSCASEWAQHKITVNGYSPGAILTPMVLHPDDAINGGPASTAMKYIGMPLDTRMLNRRSSPALYPISRSQSRSSSLVNASMLMEVSVMIERGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4B6</accession>
    <name>A0A401H4B6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620154.1">
        <property type="nucleotide sequence ID" value="XM_027764353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4B6"/>
    <dbReference type="GeneID" id="38786158"/>
    <dbReference type="InParanoid" id="A0A401H4B6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7824" checksum="56C15C428B2BFE18" modified="2019-05-08" version="1">MLAAEHSRDSDQHKRRASALFLLPSGKHSPRTSSGVAVIWPTESDRWDVGCRSRDRILLRRPVVVVRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5A1</accession>
    <name>A0A401H5A1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1602210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620472.1">
        <property type="nucleotide sequence ID" value="XM_027764671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5A1"/>
    <dbReference type="STRING" id="139825.A0A401H5A1"/>
    <dbReference type="GeneID" id="38786476"/>
    <dbReference type="InParanoid" id="A0A401H5A1"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019433142" description="Peptide hydrolase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="11">
        <location>
            <begin position="177"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE89559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="390" mass="43600" checksum="23CD812FF040E61B" modified="2019-05-08" version="1">MKTLALLSFVTLSVASVLFNGDAQVPLGGLPLSYPGFDLDLNELRWVQLEGHEPVLITELDKINLKAQGVRFFDVTETPDLGFSAHLRLANQLTFSEPQYAEKVNPILKTLSTNHLEETLRKFSSFRTRYYRSETGRESQQWLLSKISEITADYAPGYLQDLISIKEFTHSWIQKSIIVRINGSSPTDDGVVIVGAHLDSTNMWPFLPAPGADDDGSGSMSILEAYRGLLTANFTPTRSVEFQWYSAEEGGLLGSQAIAQDYERRSVNVTAMSHYDMTAWVKRGTREEVGILTDFTTPALTEFQKKLVDTYLDIPYVETQCGYACSDHASFLKAGYPVVCSFESAFENSNQNIHSTNDRIDISDEFSFTHMLEFSKLAVAFAVEQGGWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5K0</accession>
    <name>A0A401H5K0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase citE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1700390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620628.1">
        <property type="nucleotide sequence ID" value="XM_027764827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5K0"/>
    <dbReference type="STRING" id="139825.A0A401H5K0"/>
    <dbReference type="GeneID" id="38786632"/>
    <dbReference type="InParanoid" id="A0A401H5K0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="304" mass="33365" checksum="7F9EE43E962E17C5" modified="2019-05-08" version="1">MHNGTSFTEIPDFTQDPHNGFSFVPTLHHDTYPFIDPSTADLSGKVVLITGASKGIGKGIALAFAKAGASGLILIARSNMKALEAECLAAQRPGQALKVLALSGVDTTDPSHVTEAAKKAKETFGRLDVLINNAGLMESMHLIAESDPLEWWKVWEVNIRGTYNVTRAFLPLLIECGGDKTIINMSSAAAHHILPMGSAYLTTKLAMLRFTELLVTEYGSQGVIAYAVHPGSIRTDMGLFLGKDWEHTLIDTMALATDTLLWLLRERRAWLSGRYVKCLWDMEEVLAKKQEIIDGDKLKVRMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5Q9</accession>
    <name>A0A401H5Q9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1700470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620636.1">
        <property type="nucleotide sequence ID" value="XM_027764835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5Q9"/>
    <dbReference type="GeneID" id="38786640"/>
    <dbReference type="InParanoid" id="A0A401H5Q9"/>
    <dbReference type="OrthoDB" id="2740102at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13913" checksum="F3DFA0C4B8A60E03" modified="2019-05-08" version="1">MYDHLKDLQGDVIPRCHGLFKGHVEEEEAVCLVLEYCGADIAELMKDVVTAMRKIHSLRVRHDYFSATKIVAVKDHACPSANTDIVFDQLMPLVGDQEWLMCNEMRNVAESMDAWKPRTFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H608</accession>
    <name>A0A401H608_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="10" type="ORF">SCP_1701460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H608"/>
    <dbReference type="FunCoup" id="A0A401H608">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H608"/>
    <dbReference type="InParanoid" id="A0A401H608"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE89821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="462" mass="49814" checksum="43305C9D368EA76E" modified="2019-05-08" version="1">MASMSSAAEPSHPVVFTTQTPYPLPSQKFMIPTSWKRYQLSQLVNKALSLLKPVPFDFLVRGEILRATLGEWCAEKGIGEEETLEIEYFESVMPPQKMSTLPHEDWVSSVSCQISSYFLTASYDGSIRTFDYSQQLLHTSTPHSAPITCICIVPSSSPDGHIIASASHDLTARLTKLTLSTSDSPDFTPRTEPLASLHLHTAPVSSIAASPSGAHLLTSSWDSFIGLWDAAIPDSDEVPLEDVQPHTDRKKRRKFTHDDEPRPKRKAPVGVLKSHTARVSRVVFTRGGDAAAYSCGFDSTVRSWDVENSVCTNTITAASKPFLDLAVTQSGNTVLAASTDRTISQYDLRAATSSTATPSLATLAHPATPSCIAVPPPAAQSSPPSEPVSSSEHQLLSGAYDGVVRLWDLRSVRGAVTSFKVWEGNQGGKVLTLDWARGIVGVGGEGGVEVWRVGQGEHAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6M5</accession>
    <name>A0A401H6M5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620946.1">
        <property type="nucleotide sequence ID" value="XM_027765145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6M5"/>
    <dbReference type="GeneID" id="38786950"/>
    <dbReference type="InParanoid" id="A0A401H6M5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="117" mass="12864" checksum="B33895944E63D846" modified="2019-05-08" version="1">MRQLTENVQPPQSVSHTDAHLSTPPNLEPSNNHTTRSHGPTRTHTPVPQDPGWIDLRLPAPPHLHLPILPSHLPGRSCTFASKNPRPQMVMIIQVKFGGSTICNHVGTATYTRVYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G500</accession>
    <name>A0A401G500_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0101070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608147.1">
        <property type="nucleotide sequence ID" value="XM_027752346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G500"/>
    <dbReference type="GeneID" id="38774151"/>
    <dbReference type="InParanoid" id="A0A401G500"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019192208" description="DDE Tnp4 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31356" checksum="DA1847918446C4BB" modified="2019-05-08" version="1">MMNERWTIMMMQLVLLNTVIVIPNMTIAKRAMTKNEIDVLRMTVVARKWTIVLEMETVKMEMSDHCDQPRSAEEKSAYDYITLVRNEFIGWSLVQATMSVIHNIVKRNQKIDLIISSMEEDIIVARVLAKGIKDLRNMQCLQSKAQLQCSLLFTADWPTHKWNYGKQVASKDHNGTAVGGIPTGPDGKINVTSIGIDKPQYEHSPVLRRQVGMLEKYKDVDYFLWDSAGFMLPFAIRTTPVMKALLLRKKAMSVTSKRGLRTNGRVPAREGIRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G577</accession>
    <name>A0A401G577_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">U1 small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0101830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM U1 A/B'' family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608223.1">
        <property type="nucleotide sequence ID" value="XM_027752422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G577"/>
    <dbReference type="FunCoup" id="A0A401G577">
        <property type="interactions" value="645"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G577"/>
    <dbReference type="GeneID" id="38774227"/>
    <dbReference type="InParanoid" id="A0A401G577"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="45"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="270" mass="30131" checksum="A1CAC2CC82D94DB8" modified="2019-05-08" version="1">MAELSAPAMPADAMHGVAPDIAAPAPIPAGESASTPPQEPEYISETLYIQNLNEKIKIPVLKASLKGLFKSYGEVLDVVAHGNLRMRGQAFVSFESPEIAKRALKEVRGFPLYSKPMQISFARTRSDAVVRKLDSGNYEAHKARRLEHKKDTRYTNPLKQKYRTRRLAAAMDGAGAAPVSKRPNVQMPDEYLPPNKILFLQNLPESVSKDQLMALFSQYPNLYEVRLIPTKKDIAFVEYMDEGSATVAKDALHNYKLDGENKIKITFARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5F3</accession>
    <name>A0A401G5F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcriptional regulator MNL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0102570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608297.1">
        <property type="nucleotide sequence ID" value="XM_027752496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5F3"/>
    <dbReference type="STRING" id="139825.A0A401G5F3"/>
    <dbReference type="GeneID" id="38774301"/>
    <dbReference type="InParanoid" id="A0A401G5F3"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="445"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="476"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE77384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="514" mass="55627" checksum="6416297520796408" modified="2019-05-08" version="1">MDTAILLQLARTHSLVNHYVYSHDNTSYQPLVSSPSSYIRSSASRPLHPIHSHYSSYPARPNADSPASSRSTSNLTDASPTDPPLDYVTDSDSAAGGGSHIYSADYVEQPQPSSWISTDSKMHPHEFYGSGSYDLHAVLSSHVPDDAFAHQLAKVDEQQQQQQQQPQFTSVDDFALPPYYGLGADNSFPAYATFTGQHFPSTLPLTPDGIQTVPPPSVAFGFGGQVQEQPQQAFEDTEASYVLTSTPNLQYPPSPDHVPRFVHPAQVSPNISPISGYAQLHGAGTPPEVCDPRFTINSPLADDGVSPVDCDADSGCGSSSGSPPISRGRRGGSTGQKRRRANSSSSSDDEYRADQSGESEKDDEDFDDDDDYVQGSRSRPRTRRRATVSSTSPAPSTSSQGQSSMRRIAPPVPVPNLTKKSRGRRVPTAPVIVSQGGVQKNVRMYMCKVPGCGKCFARGEHLKRHVRSIHTNEKPHKCPFPGCGKDFSRHDNLGQHMRVHKGFNGLKAARAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5X4</accession>
    <name>A0A401G5X4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0104320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608467.1">
        <property type="nucleotide sequence ID" value="XM_027752666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5X4"/>
    <dbReference type="STRING" id="139825.A0A401G5X4"/>
    <dbReference type="GeneID" id="38774471"/>
    <dbReference type="InParanoid" id="A0A401G5X4"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="145"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE77554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="238" mass="26111" checksum="7535C039BF4C6C9F" modified="2019-05-08" version="1">MSPSPPPAFDDFQFFNPALHNLLPSPPPLPPSADLFSASETTDFLGFLENFNWEFEVDPQDTLHSSIQYPDHNPRFDDLPPPPLAAHNERVKSYPPPAEREPAPADMRPDTTATTSTSSSLSPPLDPSADTSMLTRVKPPLSTPQKRLNHIMSEQKRRNAIRDGYLQLTTLLAPAGAPPGSGMPTRGRPKGSGSRGRGSKGKSGILFRAREYIQFLEDGREALLQEVLKVEAAADIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G648</accession>
    <name>A0A401G648_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0105220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608555.1">
        <property type="nucleotide sequence ID" value="XM_027752754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G648"/>
    <dbReference type="GeneID" id="38774559"/>
    <dbReference type="InParanoid" id="A0A401G648"/>
    <dbReference type="OrthoDB" id="3188871at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20547" checksum="D57C0C00F0E00BA1" modified="2019-05-08" version="1">MSGSSVPSLSQWTQEHLKAVLDAASEEAFHTAFDAFISKHVHINVNGKHITREQYKQLLLGEKTFGTTAAPCTLLFEAVVEVPADSSHPAMAGTVGLFYEAVVTGRYVVLGVPNTSTIRSSLNIVITPDTSLAHEGTGYTLDTRRVSHLNEVVVDEENPMVHPKPRRASRRTSLTSPPPDANATTIVSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6I4</accession>
    <name>A0A401G6I4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0106550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608686.1">
        <property type="nucleotide sequence ID" value="XM_027752885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6I4"/>
    <dbReference type="FunCoup" id="A0A401G6I4">
        <property type="interactions" value="592"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6I4"/>
    <dbReference type="GeneID" id="38774690"/>
    <dbReference type="InParanoid" id="A0A401G6I4"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="61"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="227" mass="25608" checksum="93A2E613A3AB5F19" modified="2019-05-08" version="1">MSPQKITILQEEWERRLHDVQVSKHDLNRLVMDYLVIEGYRTAAEEFSKEAGLESPVDFESIESRMNIREALQRGDVGDAITRVNDLNPEILDTNPALYFRLQQQKLIEYIRQGRIAEALQFAQEELAPRGEESPEFLSELERTMALLAFESSPLAPAAISELLSPAQRMKTAGEVNSAILESLSQGKEAKLVGLLRLLCWGETMLSERADFPKLDLSEGTFTRAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6K7</accession>
    <name>A0A401G6K7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0106660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608697.1">
        <property type="nucleotide sequence ID" value="XM_027752896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6K7"/>
    <dbReference type="GeneID" id="38774701"/>
    <dbReference type="InParanoid" id="A0A401G6K7"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="67" mass="7735" checksum="AA97CA0CB844F04D" modified="2019-05-08" version="1">MSLGHPELIEYTATKGATIGFCARAQQPDPRRPWRPLQHRCVRPDLDAAHPSDDFQGVYRKAWHQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G904</accession>
    <name>A0A401G904_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NifU-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0115390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609563.1">
        <property type="nucleotide sequence ID" value="XM_027753762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G904"/>
    <dbReference type="FunCoup" id="A0A401G904">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G904"/>
    <dbReference type="GeneID" id="38775567"/>
    <dbReference type="InParanoid" id="A0A401G904"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="78"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="300" mass="33266" checksum="A7D6378E9E6754D3" modified="2019-05-08" version="1">MSAVSFASSSLRALKRVPKLRVHARATSALHSSSRSLSASVLRTASFYHGSTLATASTTRSGRTPSKERPLHHRSMFIQTETTPNEDSLKFIPGVPVMEDGSAEFLDTRTALKSPLAIRIMGVEGVTAVFYGPDFVTVSKDSETSWSVMKPEIYSILMEFFSSGQPLFRSEEDREAAGPQDTLILDTDSETVAMIKELLDTRVRPAIMEDGGDIEYRGFTDDCLVQVKLKGSCRGCDSSTVTLKSGIERMLMHYIPEVKGVEQVLDQEETIALDEFQKLEQRLSHEHKPRDSSMAQYMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G977</accession>
    <name>A0A401G977_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0115900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609612.1">
        <property type="nucleotide sequence ID" value="XM_027753811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G977"/>
    <dbReference type="GeneID" id="38775616"/>
    <dbReference type="InParanoid" id="A0A401G977"/>
    <dbReference type="OrthoDB" id="3205170at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="164" mass="18807" checksum="2BA9B20A9B24DF92" modified="2019-05-08" version="1">MPVKVYVPLHTAQQSAVENVLRDSGAFTLVNTGWSTCAVPVEWVMLPPMDEPADADDSDEEDTDTPTGSRFLENTDSLEEMWEHPFEPGDYVWVRAPHGSWLPGQVTRQPPHIRRTHSGDKECVYYSVEYRHRATFRRYFAPMNGEMKPDTARVRELLKEGGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G998</accession>
    <name>A0A401G998_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0116350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609657.1">
        <property type="nucleotide sequence ID" value="XM_027753856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G998"/>
    <dbReference type="GeneID" id="38775661"/>
    <dbReference type="InParanoid" id="A0A401G998"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="238" mass="26547" checksum="59D404F3550511E1" modified="2019-05-08" version="1">MPPRISSKLSRQDAQRDQAFVKDMTERYTNYLVIAETCGRTIRGMGYGQNDVARVQPVYDQAARDWRNDSTIILRTNSTDPNEQAAFFRQCDEICATPLDSLYRCFWVGFAATAGAQGLYCLFDNHPARGNIVSEATDESVRRTIGEQGFQQLAKLASSLNPQQLENASSLNPCTMDPVERIGETVRYKDENNNIIECTIEDAGTSVVKGDFFKLSYLGGGQKEVSSEEMARISRNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9C1</accession>
    <name>A0A401G9C1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0116530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609674.1">
        <property type="nucleotide sequence ID" value="XM_027753873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9C1"/>
    <dbReference type="GeneID" id="38775678"/>
    <dbReference type="InParanoid" id="A0A401G9C1"/>
    <dbReference type="OrthoDB" id="3527137at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="31"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="197" mass="22894" checksum="FFD11BC421916F7E" modified="2019-05-08" version="1">MLDKGSYLLENPTIDKDAEPWMDTPFVARYIVAERALERPMQQDMVNHWRLWFALGPNNCLVMDMVKTSVQDKSAFIGVVLKLSKRRMTEIKALPRRNDVTVRKVLDFLIRNGRLRYRFTEMGTGCAWWVAKAVADLEEHGFIRKPDGAVYTHDTMADTVLEAVKNLYEEKEDGGIQVTPFALEPRCSIFYWYVNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9G2</accession>
    <name>A0A401G9G2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609718.1">
        <property type="nucleotide sequence ID" value="XM_027753917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9G2"/>
    <dbReference type="GeneID" id="38775722"/>
    <dbReference type="InParanoid" id="A0A401G9G2"/>
    <dbReference type="OrthoDB" id="2746456at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46340" checksum="C557E14D0477C18E" modified="2019-05-08" version="1">MRSRAGLSIFRIGPPRGVPRTDRSFEPSKRSKLSKFDVERHSRSSESSKPAGRSIVPFANTDSAHGDLVKDEDVGRRTEKRAATAAPAPVSGQATSTKRPRVGFESPLYSPSTSGSAVRHPDFWLRDGSVVIRVGSFLFKLHGSRLEQESKFFAYLFSNARSVQKTIDGCPLYEIHVLSSSDFAVLLKTMDGGITYALNPPPFHTLAMLLRAAHTLQCTKFTTYASNVLRTTWPSDPASLTPERTPYAAETIALVRKCAVPEVLKRAYYELLRTPNFGQAHDEEDDVSPLGVQDYSRLTTVCEKLQAEWMQIVSAPPDHSHSQLASWAEREALKSRRHCEQAHANGAEMWVQAVVQKPVFTEGLLDPLCALQTLVDIDWSALGYCAHCVDRWRTAWRKRRERIWTDLDVWLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9V4</accession>
    <name>A0A401G9V4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-directed DNA polymerase from mobile element jockey</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0201340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609850.1">
        <property type="nucleotide sequence ID" value="XM_027754049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9V4"/>
    <dbReference type="STRING" id="139825.A0A401G9V4"/>
    <dbReference type="GeneID" id="38775854"/>
    <dbReference type="InParanoid" id="A0A401G9V4"/>
    <dbReference type="OrthoDB" id="2717295at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="151"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="509" mass="57227" checksum="04967A4F1228EC37" modified="2019-05-08" version="1">MEYHSAQNHYVDRIRTAKRDHWEAWLESADSDSVWTINKFTQAGPTDGGRTRIPPLMPTNGVGELISDNQGKSEILYDAFFPPPGTTATPPADVTYPPPAFLFTPPMDAQIKAVVKRLKDFRAPGPDKTPNEVYKRCIDILLPYLGPLFRATFSLKIYPSSWKISDTVMLRKPGQPDYMAAKAYRPITLLNCVGKILSACVTETLVHEAELNDLLANGHIGGRPGRTTTNSLHLLVKTVKDVWRRHKVASILFLDIKAAFPSALPECLLHNMRMRGVPVEIVDWIQRRLEGRRTHLIFDDFASAIFEILSGIDQGCPLSIILYQFYNSDLLDSAKLALALGHIDDMALIATGSNFEEMHDNLRHCMDRSDGAMTWSADHQSKFLLDKFGLLNLSARLPSLGPALQLCSCTVQPTSTYKFLGVLLDHHFRFREHTAYALAKGTTWVQQFCRLTKAKSGIPYPYMRRLYISVTVPRMLYPADVFLTPMRTLPGQSKTHRSVSAIKSLTRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA27</accession>
    <name>A0A401GA27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0202080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609924.1">
        <property type="nucleotide sequence ID" value="XM_027754123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA27"/>
    <dbReference type="FunCoup" id="A0A401GA27">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA27"/>
    <dbReference type="GeneID" id="38775928"/>
    <dbReference type="InParanoid" id="A0A401GA27"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE79011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="524" mass="56650" checksum="FEDCEB469941BD12" modified="2019-05-08" version="1">MSMNIFGAEATEEKAENARLSSFVGALALGDLVKSTLGPKGMNKILQSASTGDINVTNDGATILKAIQLDNAAAKILVNISKVQDDEVGDGTTSVCVLAAELLREAEKLIAQKIHPQTIVEGFRIASAVALKALEKSAVDHSTDPSQFRQDLFNIARTTLSSKVLAQDKDYFANLAVDAVLRLKGSTDLDHIQVIKKVGEKLTDSYLDEGFILDKTIGINCPKRLENAKILIANTSMDTDKIKVFGARVKVDSTGKLAELERAEREKMKAKVEAIATHGINCFVNRQLIYNYPESLLAEKGILTIEHADFEGVERLSLVTGGEIASTFDHPDKVKLGRCELIEEIMIGEDKLIKFSGVAAGEACTVVLRGSTSQMVDEAERSLHDALSVLSQTVKETRVVLGGGCSEMLMSCAVEEEARKVTGKKAIAAEAFSRALRQIPIILADNAGFDSSDLVTRLRAAHYEGQSDAGLDMNEGTIGSMQKLGVTESYKLKRQVILSASEAAEMILRVDDILRATPRKREAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAH3</accession>
    <name>A0A401GAH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0203670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610083.1">
        <property type="nucleotide sequence ID" value="XM_027754282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAH3"/>
    <dbReference type="FunCoup" id="A0A401GAH3">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAH3"/>
    <dbReference type="GeneID" id="38776087"/>
    <dbReference type="InParanoid" id="A0A401GAH3"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="504" mass="54903" checksum="93315D6E94BD3953" modified="2019-05-08" version="1">MPAIAEIKVPATGKTIKVPTGLFINNEFVDSVDSKERIDCVNPATEEILCSVIAGSEKDIDVAVSAARKAFQTTWGKNVTGVERSRLLHKLADLIERDAQELGELETLNNGKPVRIARDFDIGDSVGCLRYYAGWADKIVGETIEVDNKTKFAFTRHDPIGVCGQIIPWNYPINMWSWKVAPALACGCTIVMKPSELTPLTALKLSELIVEAGFPPGVVNTVPSLGSVGGAALSSHKDVDKVAFTGSTVTGRRIMEAAAKSNLKKVSLELGGKSPHIIFESADLDQAANWVALGILYNTGQDCTAGSRLFVQDTVYDKFVQILVQKAKELKVGDGFDDNNSGGPVVSKTQYDKIFRYIDYGKQEGAKLVLGGEKRPTKGYYVDPTIFTEVKPDMKIVRDEIFGPVLSVAKFSTEEEAIKLANDTTYGLGAGLHSNDANQCMRVSSELEAGTVWVNQYNMLQNNVPFGGKKQSGIGRELGSYALEEYTSVKAVHWNFGEQLSWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAK6</accession>
    <name>A0A401GAK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0203950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610111.1">
        <property type="nucleotide sequence ID" value="XM_027754310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAK6"/>
    <dbReference type="STRING" id="139825.A0A401GAK6"/>
    <dbReference type="GeneID" id="38776115"/>
    <dbReference type="InParanoid" id="A0A401GAK6"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="37845" checksum="137473B3794C9759" modified="2019-05-08" version="1">MLRRRYHPDWTPSWRGTGKHPLYFEDAIALPPRDDVIDATRIADGKLVYIKRVGTGDKETQIATMLSAEPLVQDPKNHCVPILEMFPDAEDEDISYMVMPFFVLIDSVPFECIENIVDFTDQILEGLVFLHERGVAHRDCTYKNIMMDVSAMYPEGFHPVNDLFLPDGLTPLPSRSRTDVPIKYYFIDFGISVVIPPEVYPKLVLGDEGRDQEVPELSLTVPYDPFKTDVFIIGNALQHCFHDRFSNVDFLVPLIESMTQADPTARPDAADALTQWQEIRCRLGFLQRRWRVIFRGEPWYWTAALDTVSFINTTTYIFKTACRWVVGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB33</accession>
    <name>A0A401GB33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA-processing factor 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0205730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610288.1">
        <property type="nucleotide sequence ID" value="XM_027754487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB33"/>
    <dbReference type="FunCoup" id="A0A401GB33">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB33"/>
    <dbReference type="GeneID" id="38776292"/>
    <dbReference type="InParanoid" id="A0A401GB33"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="265"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="537" mass="58034" checksum="BD7EF8061E7BE27B" modified="2019-05-08" version="1">MSALADELLADLEGLSEGEGEEEEEEVEAKPGSSTGVKRKAREDEEMSDGDGDGEAESEGEGDQGDKTVGSLVLEGGIKPSEELDAEEVQRMDLGGVEDVRKVAKLDGSKRMNDTLKEIEKYQANPSTAEQMSMPAHSNPEYTLIVQANNLSVDVDNEILVVHKFIRDHYAPKFPELDQLVVDPAMYIRSVRALANHEDPTKVDLAGILPPAIIMSVLVTATTTSGQPLSDAEWKTVQHACDLADRLEEARKKIFMYVSSRMNVLAPNLSAIVGTTTAAKLLGVAGGLNGIAKMPACNVYLLGAQRKIAAGFSSVTQRRHSGFVFQSELIQQTPPEYRLKVQRTVGAKCTLAARMDLERNRRDGSYGEELREKIEKHIDRLAAPPPSKIVKALPIPNDGPKKRRGGKRARKAKEAYAQTELRKLQNRMAFGEAEEEIGAFDQTKGLGMIGSGKVRAGAGEAKSRAKMSKANKLRTAALTRAAQAGGTQTSGTATSLTVTPVQGFELTNRAAAAQRVKEANERWFAGGTFSFVGQKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC10</accession>
    <name>A0A401GC10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DIS3-like exonuclease 2</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0209270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNR ribonuclease family. DIS3L2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610639.1">
        <property type="nucleotide sequence ID" value="XM_027754838.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GC10">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC10"/>
    <dbReference type="GeneID" id="38776643"/>
    <dbReference type="InParanoid" id="A0A401GC10"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990074">
        <property type="term" value="P:polyuridylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03045">
        <property type="entry name" value="DIS3L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028591">
        <property type="entry name" value="DIS3L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNB" evidence="7">
        <location>
            <begin position="889"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1392"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="901"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="910"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1464" mass="160331" checksum="72C2479F96CA5300" modified="2019-05-08" version="1">MTDDITQLQQQNVSKKDDKKAIPAGGGGRSQKRTGPVARTASIGGGNASASRPSSRSSNKKGNAPVATESGSDSAKKGAEAKRTEQRSRTQGNSNARSNAHRKGQQSTSQGVRQGANAPKDGAAAKQKQASASPAPAPVVDNSDALSSLQRVIADLKTTSPPSQSPSIAPTLIAASMAVPSQGNGSTLPANAPIFHPGAIAFPSAGIPEPPRHRKAASLGTSSGVAYNSYSPNLGSMMEDVEDGQVQALVEEGEIQETLAPAGHQRRSLSQSFTAPRFAALAAQQDQGEVLGPSGRPQLAPGFMFGARRRPSASMSMGPSINEEDIGFQFPQQSQQSFNADVKADSGPEISGIMAEQIAIQNQIEALQQQQQALYQQQLASNQVLSFQTPGLAPGRGPAHRRVHSTVPMGMGINAFGGPQAAMGQFGSLGSLGMGLDGQPQGVPRGHGRRHSVNVLNKTSGQTALGSLGFSNSQDGFDDGFTPPAGLAGGSSHTRSDSSWRINGGVGGIQTGNNFAADLAQAQAQLQSLQQFRAAAGGHHQKMPSFSFPNMLPNMMAANMMGLGLGGINLLQQQQQQFQSQLQQQSNQPQRKSLFAPYLPQASLPPLLAAGKLVVGILRVNKRNRSDAYVATEVLDADIYICGSKDRNRALEGDIVAVELLDVDDVWGTKKEKEEKKRKKEENSAYDLKGVAGRKNDKKKDDVEVEGQGLMLFEDEEVTDDVKPQFAGHVVAVVERMPGQLFSGTLGLLRPSSAATKEKQEAERREREGDRGDEPRRPIERPKIVWFKPTDKRVPLIAIPTEQAPPDFVQNSEAYGNKLFVACIKRHPISSLHPFGTLVEELGPIGDVEVETSALLKDCNFPTEDFSESVMKCLPPIPWSIPEREFEVRKDMRNERIFTIDPERAKDMDDALSVKSNDDGTYDVAVHIADVSYFVKPNTALDRDARKRATSVYLIQRAVPMLPPALSEQLCSLVPGEERLAFTVIFTMTKDAKIVKKWFGKTIIKCAAKLTYHDAQTIIEGKSVRLDTTTEHTLADVIRDVRLLHDIAKQLRTRRIQNGCLKTETMRLTFKLDDDTGLPTDCWQYERTEAHHLVEEFMLLTNIATAQQVAVNFSEQALLRRHDPPIERRLNAFVEHAERLGYNMDITSAGSLMRSLQSIDDPIARRILEVLLHKASPRAKYFCSGMLDIAKYGHYALNLPLYTHFTSPIRRYADVLVHRQLDSIMQGGAEPKFTMDRDAVAKVAQQCNIKRDSARLAQEQSAHLFLCILVSDLTQRYGPVVRQARVIGVLDAAFDVLVPEFGIEKRVHVDQMPIDNHVYDEHIHTLQIYWSTRDVISWLAENSDDEHLKKVKQTAEQHAVKMEVVSRSVHDEKALFDEDDAEEDEIVLGRTRDREEEETETSKQRLSSKTKVQPQFEGLKVTPSGHKIQEIRELMTVPVIVTADLTKSPPVIKVYSVNPYAGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCA2</accession>
    <name>A0A401GCA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0209910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610703.1">
        <property type="nucleotide sequence ID" value="XM_027754902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCA2"/>
    <dbReference type="GeneID" id="38776707"/>
    <dbReference type="InParanoid" id="A0A401GCA2"/>
    <dbReference type="OrthoDB" id="2679843at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19151" checksum="05A22BCB794D152F" modified="2019-05-08" version="1">MQDALEKYGTLSDAVATASVLGAGITYTTIFNALRGNIGLMCWSFALFDVGLIITILFRSIMTALWHFQLPRKPFATVFWWELMIKVVLLMALISATIAIFLLSMSALQLVYPRPEGYQDAVQLTMSPVPSAALSMFIVAGGIAVLVGVFALLFWAGGFRKDDNPREAVQDYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDA2</accession>
    <name>A0A401GDA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0213140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611024.1">
        <property type="nucleotide sequence ID" value="XM_027755223.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDA2"/>
    <dbReference type="GeneID" id="38777028"/>
    <dbReference type="InParanoid" id="A0A401GDA2"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="484"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="505"/>
            <end position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2146" mass="243427" checksum="250489A23973683A" modified="2019-05-08" version="1">MKNFKTQKRAHASLDLNILDGRLLCDEVALEIAIGVLETHLDNRAADIEVLVEDLFPSQHLLEFSLSVICDATFIAVSQRLLDNFPKDPRIFSSSLACKLIERFSLYHYFLSYPPSEEPLDLRERRQSAQLSTRALEALLTSSLFADDLGASGSKPSKRKKASGTSARPGGVSLESKPFHDLRMDVPHSRREAEGLADHIMRNLKEVLQYYLNVFRYPQLRNIFKGTYIPEHAPSDDVVVVSPKCHASHGPASVSQEVSKPTVDNGSEIFPTMQHAQMTLDADNADGFGGWRVLISKPAASDLRQKFKKDPELFRIIMKKIRELSNGPSFWTQDNHKRMNVRNEFDVPIYAAKLARDSRLIYQIDCVPDFQRNVDTQVLKIFGIFTHAQMGEHLWDSVGHSLSGKGREYKRRCVFRNQSVNSVVLPACFPPLSVSESQQRSSSLPTLHKEDLGKLHELLVLDKYYPFSKALLNSILGDLELSLVFQVSTEEQRIVEHQDSCYVIGRSGTGKTTTMLFKMLRIERLWHLDGDRLPKPRQLFVTKSRVLAEKVQQHFGQLIEAHGAADLSLQALSAMKTKMNILPSGLYDADEMADLGSYLPKRWTALRDEHFPMFITYDELARLLENDMTTSGITQSTALARQRRSFVTYDRFRMAYWPHFPQPLTKGLDATLVFAEFMGVIKGSEEALASSAKYLDKDNYQKLKNRRSHAIVANQADVIYQLFLIYSRMKRERGEYDVADRTHRIWDGLRDDGVPGRQVSFLYVDEVQDNLLIDLLVLRMLCGNSSGLFWAGDTAQTISVGSAFKFNDLRAFMHRVETTVISSSRPRAEPEFFQLCVNYRSHAGIVNCAQSVIELLMLFWPNSIDSLTQEKALIDGPKPMFFNGRDENSVQYEQFLFGDSGSGNSVEFGAKQCILVRDDAARERLRARVGEVGTIFTLYESKGQEFDDVLLYNFFEDSTVDSAKFRVVLNALPQQYSQQYSTPAPLFDDIGHSSICHELKCLYVAITRARKTLWIADNPDKFDPMRIFWTSRDQIDVWIPGSKVPRLATSSTSEEWAHAARTHFENKHYTQAMHAYDKASMAGEKAVAEAFYLREKARNTLDVGGTARSIAFGDAAEAFRVRAEIATARERKAYFRIAAQCYGESGKPRPAAQCYIHADDYAEAALSLRDAELFDEAVQIIQSHRIHVEEADADLVISSAISYYFKKSEARKAIPLFSSPDKALAYMEECDLDVERVKYLERLNRFSDAADLHLAKGLPLKAIQLYLKCPQDMRSVRRAEQCLLGQLWLHLSFGVKPTTEKKIFRDLADFTTQFSGLSNATPNSQRLISMFRAALTDDLKQLHLLYPTLLSGDIAARLLCLDHIFMGTACFKKSDQAEAATILENFRLYLNLMAKVAEGQYSGIDPALRQLFGIQYSIPNGYVLSAGTFLHRMAAVFGSHSVKAERTRHPKKSISLSIAELVLLIRHSLQDRLRSRITQEDGVFRQTYIFAPCLSFAIFGCCNDGPATCLRDHSIADSLDSSSYHTRIGILLSRIVIYERFHWVFSDDKFGYQMMQRSILEDLYHAVIPSMLVCTSVPALTADCIPAFDEGIQVVKRWIQSLICDRQSLLRSNLWLTTAELMTLEFFLSRIQVKRDIEIATIFRNCSLIHLLRGWEDDRRDTVRDLLWALKALGSSGTSFGVLYAVHILDHKLPADLNVLCDLLEYLCGSFVLLDRTQSVHQLHDITLPRRWLLNFERWNLERVDYDDCEFLAIFLRPMSALLGGLYTGQDIDYLSLDGSKIDSDQGSRFILRICRMLALLGYNSQNEEFKWDVLSVLKSLRSTNFQSKLPYSSYINVSGWDDVVDALQPTFPETCMDQLLHLSKRDMTKGVIHGKRLKGIHRVTFWHSEQILPSVAADLEFSARATRTARTNPIVEPPASPVIAIHKSITVGPAPRQDLIEMAEDQIEDRDDVHSTASDLEEPADDEAMSIAVSEEKIAAASYFARTYRRILNRRRNETETQVSRLFSACLLENQAESSNVRGGRYRLFFLGPLPHILLSLQGILTHAESSKKVAKAHFTSAVGMEQDRWKVQLTKDTSLIRDAKRLQKILEPSSNLHIKGDLCELKSQFMEVAELGSKYDIPREVAKRWEEDLRLAVMVFAAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDD2</accession>
    <name>A0A401GDD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0213990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611102.1">
        <property type="nucleotide sequence ID" value="XM_027755301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDD2"/>
    <dbReference type="GeneID" id="38777106"/>
    <dbReference type="InParanoid" id="A0A401GDD2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="126" mass="14486" checksum="4EC4FDF98ED3B081" modified="2019-05-08" version="1">MLPAADTTEEAQDIEPAVDSIPKSQATPFPLPCALISISPECSEQQRSDAIYRNIRLLERALEEQKIRIATSQTRCFYLQCKLRVLQRKLDAQSLKHKEKVCRSELCFMVRRARKAGGKRRRRDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDH5</accession>
    <name>A0A401GDH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0214270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611130.1">
        <property type="nucleotide sequence ID" value="XM_027755329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDH5"/>
    <dbReference type="STRING" id="139825.A0A401GDH5"/>
    <dbReference type="GeneID" id="38777134"/>
    <dbReference type="InParanoid" id="A0A401GDH5"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="147"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE80217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="567" mass="60597" checksum="3DBF174A01BBEFCA" modified="2019-05-08" version="1">MTVISASIVKHTTASSPRPHVLYCVKVTTDDGQKFEVAKRYSEFVDVHSALADSEVLPPKRIMVTSFIPSAWVDDKLIAERKEGLNSYLTTILGLPEYREHAALVRLLTPVSSAPAKFDPEDALPSTLSRKTALELQGKLSAAATTPIAAAYYPDWASATNPPQGVDFSKFDVLLFAFATPNSSSTISYDSGSTSTLETLVSSAHNSGYGTKVVLSIGGWGGSYYFSQAVGTSANMTTFVNACVSAVNTYDLDGIDIDWEYPGESGAGNPYSSDDSANFLAFLTSLRSALGWSKIISAAVTDLPWQGSNGSPLTNVAAYAAQLTYANIMNYDVWGASSTPGPNAPLGNLCGTAQLPQYSAEAALSQWTTAGFPASQLVLGLPLYGYVSESTATTLAEIALPPPGFRLAEYRQRVLGLPMRNPLSNGGLVCELPQRAANKPSGKPNPLNGAHPHARSKVVTENANLSSYWGQQIAFNQIVALGALTETSWKTFQEAGGYTEGWDNCSDTPYLFDVSQATVVTYDDTYSLGDKATFAKQNGMAGCFTWSLDQDYNYVLQDVIRSSLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF41</accession>
    <name>A0A401GF41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0305340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611727.1">
        <property type="nucleotide sequence ID" value="XM_027755926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF41"/>
    <dbReference type="STRING" id="139825.A0A401GF41"/>
    <dbReference type="GeneID" id="38777731"/>
    <dbReference type="InParanoid" id="A0A401GF41"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF506">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE PMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="256" mass="27354" checksum="42F50D18454B8E25" modified="2019-05-08" version="1">MRQSELSFNSERKYMAVSGVHVSSTTAPNGTTIKETNREMYYIKGSIDAILERCKFYYVSDESTPALDANTRNVVLSQAQKTASRGLRVIAVAYGFGTVEAASRSSSRSSMLPATQATPPSTPLPTIDREKSKNNLVFVGFQAMLDPPRKGVADSIALLQSGGVQIVMITGDAEETALSIARALGLRVGSGSSGCLTGQVIDRMTKQQLKERVGGVSVFARTTPRHKMAIVEAFQARGAIVAMTGDGGMYVSFLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG77</accession>
    <name>A0A401GG77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Splicing factor U2AF-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0309240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612110.1">
        <property type="nucleotide sequence ID" value="XM_027756309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG77"/>
    <dbReference type="FunCoup" id="A0A401GG77">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GG77"/>
    <dbReference type="GeneID" id="38778114"/>
    <dbReference type="InParanoid" id="A0A401GG77"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="144"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="416" mass="45709" checksum="D6F503502E7A6990" modified="2019-05-08" version="1">MSTSEPNSAAPPAAVAGSTAAEQAAAFADDPRVHFDRAAGAWRLENDDGTELEYDAAKGAWLPLVDEDLVKAQQAAYSVAGVDEETPAAPVLARTAKKRKEPEDYTSSTVGQPSGSSIKRSKKGAALSSKDNGAAPPERKSKNTAVYVTSLPLDTEADELVECFSRFGLIEEDDDGHPKVKMYAREDGTFSGEALVVYFKEDSVNLAVSLLDDTELRIGNASTRMKVQRAEFGHKHEKGAAEGGEAKPRKTVTDKKRASRRIGKMQKKLGEWDDEDGFGPHITEEDKANATNKNNRVVVLKYMFTLDELEQDASLLLDLKEDVREECSTLGEVTNVVLYDKEPDGIMSVKFRDPLSAQACVMKMNGRFFAGRRVEASLYAGKQRFKRTTDESFVGEDESEKKRLDDFAQWLMTEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGR8</accession>
    <name>A0A401GGR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0310960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612282.1">
        <property type="nucleotide sequence ID" value="XM_027756481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGR8"/>
    <dbReference type="GeneID" id="38778286"/>
    <dbReference type="InParanoid" id="A0A401GGR8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="136" mass="15644" checksum="C17B508B815752B6" modified="2019-05-08" version="1">MSYRGCVLRLDSLETDPNFQVLRVAQILSSFSPPPMHLHIIVKFMIKPVHPEFAKIGDAIQSIRNMTVFIARYGRWARSDLNIFDNHVSFAFDAEQEPSFPPTADRFPNFIVDFANALRRRRSVSKQAKAGRFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGX9</accession>
    <name>A0A401GGX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0311140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612298.1">
        <property type="nucleotide sequence ID" value="XM_027756497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGX9"/>
    <dbReference type="STRING" id="139825.A0A401GGX9"/>
    <dbReference type="GeneID" id="38778302"/>
    <dbReference type="InParanoid" id="A0A401GGX9"/>
    <dbReference type="OrthoDB" id="3262547at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="562" mass="60412" checksum="275C40521C297438" modified="2019-05-08" version="1">MSSLSDHVDRITQLARSIRSAATSTSSVESDSPSGSVGPFTNAVLHTPLGDLIRDIDPAELGLFTLVPPAKPPTHDTDPPVPPHGEIARVEFLGATPLRKPPAPKPGRSDIQRTGEHEPEVYARAALKYLDRYQSIRPMPRASEQAIRIVEQLAAVRESIHGLNNQAKQTAPVAPSQPPLSPKSIFAEEERRIQDAHQRIAELRKHKESLMKRKSNGRTISRAAPKAKPKPQTPQSMSPPDEQEETFWNTPAAAARTLHFTGNSLLDEDVNEELANVSALSFASPVPARTKSGSLRGGRPSPCSDLKLEEREQEDQAYDIGSSVQVDLQHAYEGGEDLDAEVSGVLDDEGAAEDKEQTVVLQRLPSHLKQFQDTSQPDPEPDPRMSSPSSSGPLPAAETPSGSLRRSKVKVTTELEHIVSKIWATIGEVVMPGCRFDVSGAGSNRPPRAKETIAHLQTLSTLTPSPSSPTTSSLSSFSTAAIPPASAPSQPTAQQILTAHMLLALLSTPPQYAMPLSRLKETLATKSAAGGGAVTRPIYGCVAKRLLKIERGGGEQIVKFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI65</accession>
    <name>A0A401GI65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extragenic suppressor of kinetochore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0402220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612761.1">
        <property type="nucleotide sequence ID" value="XM_027756960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI65"/>
    <dbReference type="FunCoup" id="A0A401GI65">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI65"/>
    <dbReference type="GeneID" id="38778765"/>
    <dbReference type="InParanoid" id="A0A401GI65"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="776"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="841"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="572"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111976" checksum="4984841E1A3319FD" modified="2019-05-08" version="1">MFWRFGFHNASSIDALLDREDISLEAILDEDELLQECKSQNTRLIDYFQRVDVLQRLLGYVTGQIEGEDRGRFKYPYVATEVLCSEIWSIVETCVTHADQLLTPFWEVVLDRPPDDMKTQMVMASHFAKINATFLSKKPAEMLAFIQAQPAVVERLLRHIETPAFADLLVRIIQLDEIPAGAGVLEWLSQENLMSRLIDLLSPAYSSDMHTVVSELIKGIISMAAPSPGAGVSDGNNAPPSNRFARELAHRDSVTKLTSYILCKFPPAPSENGPNQEPHMEDDDCAATLPSLESATSSVVQSICIIIELIRQNNSDYFEPYLFHTLRNRLIQIQQHLQMNTDGGREKLEQAMKEMVNRMGVVHLGPVLEIMCDHLDELQQFLLHPRSLDGPILTTVGSLNPLTFERYRICELYAELLHCSNMSLLNRTRDYDHLYDSEGRLQGGLSALEELAQVIAIGSGGENDQDSMDDEADEVEHTHDFPISNASHDTSSLIDSDEDMSGDDEPGSSDDDAMEEIAMYDEPRPMNTSPTITESPLERPPATVLSSSPIASSSPSTSDIAAFPQYRQNSWNSNSDSDSPSRPRSSSSRRSVRRVNTNDTPPGPPVLGERLKQRFLQANVMSTLLDLFFDFPWNNFLHSVVYDLIHQILTGRIDGGYNRELTVALFRDARLMHRIIEGSKRNDVESAKPKGVRLGYMGHLTLISEDVIGALEHFPPDLRLLAAQYAPQPEWDEYVTGRYKETKKKDTSLLGGGKPVLAPGMRSGPAMQWRVDEADADSQVVVPSDDGGDNNQQMKSEFRRTPKIREGSADFGPASMDDEDDEFSTAGPPHFAHYLAQEMQSAEHFESSDEASDDEEEDSGWLAHSTFDLPSPPVSARQHINNGRRPLSSNGFDDSFVPASSPHSAFEDPFEDDAFGPFSDSAAASGSDPFTFPSPFGEDSTETSSFDDNFGDFGDFQSASSGSVEGEGTQTPTGADSWSFASISSTGSFDDSAAERRAGDAASEQSERTAQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIA0</accession>
    <name>A0A401GIA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0403080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612847.1">
        <property type="nucleotide sequence ID" value="XM_027757046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIA0"/>
    <dbReference type="STRING" id="139825.A0A401GIA0"/>
    <dbReference type="GeneID" id="38778851"/>
    <dbReference type="InParanoid" id="A0A401GIA0"/>
    <dbReference type="OrthoDB" id="2860408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="611" mass="67250" checksum="BF565B1A5ECA3FB4" modified="2019-05-08" version="1">MPDFGSQLDVHESQLPFSIQYPLPPPLGAVFDEYHFPPAARQQHFTPALPVYPYLSHYDHVPTVAHYPRATANPGTAYYTHEHRVWSQAVEPEHDPPQRDVIVYDVSHSISHNSPMMSRPISQQEIPESAFLPQQQYEDATDIPDSVSNIQRSNMLPPSAPSTAETEHSSGSDIAASKSRADRPKHSPNQSKKDPKGDPYAPAFIQATIGEKKWEMFTARLAEKRIGRHRGKYKATPTNSSSLQGQDQHVDSAADVDTSSGKDRSASVIDFLVKVEVVKAVLRAYVPHPYNPLKSLTHPYERAPSGHVTLTRSTVLALCGWSNTQFSYWARRAEAVSVLAPLDVRLRAVARALQHQLYVVGVSSAPAAQQDHPLTEGGRAHDGVAAMTEEWVDTCVTGKGLDNIIDEVKKRSGASPFLRGRHSSLDPFGTINGETDGGTNSNDQPAVGMMCMPIFQAEKYVHEVPAETGRDHDHDGNSVEMSQTQSKRRSWDDCSTSAGASSSPVSASDMSNLQYPQTPAMVSHPEDVPQLSFQLSDSRGDSLLPRVLDGGSQHAYAQLRMPLMSNAPRPRSSGYLLPFPKALSDLSYAEMHAHMQLPDQLERPRKKSKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIB6</accession>
    <name>A0A401GIB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0402910</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612830.1">
        <property type="nucleotide sequence ID" value="XM_027757029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIB6"/>
    <dbReference type="FunCoup" id="A0A401GIB6">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIB6"/>
    <dbReference type="GeneID" id="38778834"/>
    <dbReference type="InParanoid" id="A0A401GIB6"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="193"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE81917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="413" mass="46659" checksum="0F24A6EDAFE1B3C2" modified="2019-05-08" version="1">MDEIGIEIQKEEPTFGSVVTEKAALFQGLQEEEDLYIKYKKLARHLEMLEIQESYIKDEQANLKRELIRAQEEVKRIQSVPLVIGQFLEPIDQYTAIVGSTTGSNYVVRILSTLDRELLKPSSSVALHRHSNALVDILPPEADSSISMLGKEEKPDVTYQDVGGMDTQKQEIREAVELPLTHFDLYKKIGIDPPRGVLLYGPPGTGKTMLVKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPSIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQGSNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPSRREKRLIFQTITSKMNLGPDVDLEDYVSRPERISAAEIAAIVQAAGLQAVRKNRYIVLPADFEEAWKQNVKRADDMLDFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIX8</accession>
    <name>A0A401GIX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0405440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613077.1">
        <property type="nucleotide sequence ID" value="XM_027757276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIX8"/>
    <dbReference type="STRING" id="139825.A0A401GIX8"/>
    <dbReference type="GeneID" id="38779081"/>
    <dbReference type="InParanoid" id="A0A401GIX8"/>
    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28011:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="123" mass="13860" checksum="6EE9C2C0504A1077" modified="2019-05-08" version="1">MPSPTFLSSPVASFSVSHSRNTLFATVGVKAWSISPLTRVAIHKLCMAPALLSRTLDPFLGVFTGVFAYYLHETNPRSAVPRDDRLVELMKWKWSKRKREREMHLANDDDTVLTAVSANLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJB0</accession>
    <name>A0A401GJB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">SCP_0406240</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613153.1">
        <property type="nucleotide sequence ID" value="XM_027757352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJB0"/>
    <dbReference type="FunCoup" id="A0A401GJB0">
        <property type="interactions" value="726"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJB0"/>
    <dbReference type="GeneID" id="38779157"/>
    <dbReference type="InParanoid" id="A0A401GJB0"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="7"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="758"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="758"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="779"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="GBE82240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="803" mass="91642" checksum="5DB39BDF43260699" modified="2019-05-08" version="1">MKFQIDDLPIIFPYDRIYPEQYAYMCDLKRTLDATGHCVLEMPSGTGKTVSLLSLIVSYQQFYPTKRKLIYCSRTVPEIEKALAELKRLMEYRLSCAETEEEKQKERNFYGIGLTSRKNLCIHPEVSKEKKGKVVDARCRDLTNSAVCEKGRQDPGSVDLCDWHENLGKLEPGNLIPPGVWTLADVLQHGRDNRICPYFLVRRMMPFVDVVVYSFHYLLDPKVAEQVSKEMSKDAIVVFDEAHNIDNVCMESLSIDLTRPMLDSATRSVGRLGEKIDEIKKTDASKLQDEYAKLVEGLQEASADEDAFMTNPVLPEDLLKEAIPGNIRKAEHFVAFLKRFVEYLKTRMRVLHVVAETPLSFLQHLKDITYIERRPLRFCAERLQSLVRTLELSRLDEHSSLQKVASFATLVATYEKGFLLILEPFETDNATVPNPIFHLTCLDPAIAIKPVFERFSSVVITSGTISPLDMYPKMLQFTPVVQESYSMTLTRSSFLPLVITRGSDQVAISSRFEVRNDPAVVRNFGSILIEYTKIVPDGIVAFFPSYLYMESIVAAWNDMGILNEVWKHKLIFVETPDANETSIALENYRRACDNGRGAVLLSVARGKVSEGIDFDHNYGRAVIMFGVPYQYTESRILKARLEYLRDAYRIRESEFLGFDAMRTAAQCVGRVLRGKTDWGLMVFADKRFARADKRAKLPRWINQYITETASNLSTDMALSLSKLFMRTISQNPNENQTGISLWTLEDVEKAQAKQKALALETEQQQQQQQQQQQQQRDEAMDEDDYYGDGGLDDEVLGQIDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJD3</accession>
    <name>A0A401GJD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0406600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613189.1">
        <property type="nucleotide sequence ID" value="XM_027757388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJD3"/>
    <dbReference type="GeneID" id="38779193"/>
    <dbReference type="InParanoid" id="A0A401GJD3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="78" mass="9313" checksum="3B26A67CE89069BA" modified="2019-05-08" version="1">MKSRSIERRKTENGGRGMHRAEEHRILKQNMAQPYQKSEEVAQDVVLSQWILLNSSFESDLLLLDPGENLREEFRWWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJF8</accession>
    <name>A0A401GJF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0406740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613203.1">
        <property type="nucleotide sequence ID" value="XM_027757402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJF8"/>
    <dbReference type="GeneID" id="38779207"/>
    <dbReference type="InParanoid" id="A0A401GJF8"/>
    <dbReference type="OrthoDB" id="2800500at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="273"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="989" mass="111233" checksum="F7B26B1FC287EEAB" modified="2019-05-08" version="1">MSRRNKSRLVVDLDDEVEFVTKVAKQTTRGVRYVDVPLPMPTGSNVPSPSKSPLKAPASGSLFNLDDGNVLGNIGVPIQLDPAARKTKTQNDFMRDWIPHCDDYLHAIVEMEAPPEPRNCAECKVGEGRWQCLDCMGRLLTCTDCCRNGHQRAPFHRIEHWQGHYFEPASLYRVGVCIHLGHGGDSCPLGAFTAHNNPAPVVAPRSDFWNASNEDLNAHDGEVSDDGEVPFNFAPLASTLDGEARQTDDAPDPTWEEDVPPVLSRPPRRDSYGNRTIVIVGISGVHHIGVDWCQCEMAVERDMQLLQMGLYPGTVKDPHTAFTFAVLDDFLLENKECKTAALNYYSKLKRVTSNAFPGTVPDRYRELMRVSHQWRQFKYRKWHGFSHDALRPVEKGGLAIFCPACPQPGLNLPFDWQADPVQWKFKRGFVMDGNFSAEHMKMKHPEEDVALSDGQAFMVGQEDYKAHLAVAMESHQRSTCHEHRAVNQANVDRANLDATGIGATACARHGFFVPHTVVNFQKGERQMNMDYSLSNALLTLTGITLILVMYDIMCQYGVHVRKHFRHSAYLRMPFELKVDQGIGLFHVHGHQDCCFQRFSPNFIVGAGMVDGEVIETLWAPTNEGSGSTRGMTRAHCQEVLDDHMNDSNWKKTTRMVPTLMTKWKRVLLGFPRSKESFEALSASTDEDVLEAWQKEYDDAMEARQNDPKIMDTFDVQLMKAPGKDLTQLRLAGEESAKGLEKGTARWLSTGLKIQETQLKLANDIRKAGQNPSVAEDLKTLERRQRLEVSILTFQRRSEKFMGRLEDVPAMEDRDDGALWDFLDENPFQIHPEDAEYGEDAIPPERASLNLPLQIGFVAAVANGLQTLAAQELELRKGLMNDILHELRMALGLKSYLYRKRVHPANSVGTMTRAQAEVHAADQTVLACARLYSANRRTIMRLDATDEDLALYRPLDKKDLHVKTAVIEASTSGLRNVNLAWFWTMDVAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJJ3</accession>
    <name>A0A401GJJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposon Tf2-6 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0407150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613244.1">
        <property type="nucleotide sequence ID" value="XM_027757443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJJ3"/>
    <dbReference type="STRING" id="139825.A0A401GJJ3"/>
    <dbReference type="GeneID" id="38779248"/>
    <dbReference type="InParanoid" id="A0A401GJJ3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="739" mass="84612" checksum="57EA08F67EFB1CF2" modified="2019-05-08" version="1">MTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLKKGYIRLSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNTYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNHGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHIRTQHVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKEIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPWTNLTRTAAGSPPFEWTTECQTAFDTLKQQFSTAPVLLLPDKAKPFIVESDASKFATGAVLRQADINGDLHPCAYISQTLNLAERNYEIYDRELLGIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDALSHRNGLDDSESDNEDRILLPNALFMRSISPTLFDKIRNHAAKDLIVHEALEAIAHKGPFPMKSSLSDWEVRDGVILYKGKIYVPLSETLHRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVKGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVVVDHDLTKGVILTPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJS6</accession>
    <name>A0A401GJS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0407990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613328.1">
        <property type="nucleotide sequence ID" value="XM_027757527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJS6"/>
    <dbReference type="STRING" id="139825.A0A401GJS6"/>
    <dbReference type="GeneID" id="38779332"/>
    <dbReference type="InParanoid" id="A0A401GJS6"/>
    <dbReference type="OrthoDB" id="2266637at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="2">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="146"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="319" mass="36235" checksum="E36ABFBAF5C24CF6" modified="2019-05-08" version="1">MSPHLSQQLQECIVTWRQEGKPIREIAELAGCSERTVSTILSLYRDYGIVSNPNARLRGRPHALDTGDVNYLSALLQANPVLYLDELQEQLIHSHGTDASIATLSRALRHLSLTLKKITKEAAERDDLLRATWIGEYGDIPMEYFIWLDESSVDDVTNQRRRGWSGIGRACVWREMFIRGQRYSVLSALSIDGIIALDIFEGSVNKERFIKFVEEELAPKLTPYPGPRSVVVMDNCAIHHDEEVRQIVVDDCGAKLIYLPPYSPNMNPIEQAFFSIKAWLRRHEAAAIDADVRPWLIHQASLSVTPEHAEHWIMNCGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK76</accession>
    <name>A0A401GK76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin-2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0409330</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613462.1">
        <property type="nucleotide sequence ID" value="XM_027757661.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GK76">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK76"/>
    <dbReference type="GeneID" id="38779466"/>
    <dbReference type="InParanoid" id="A0A401GK76"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="75"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1299"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="628"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="980"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE82549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1630" mass="184419" checksum="2CD1584BE9396654" modified="2019-05-08" version="1">MAENIYSKGTRVWFTDKEHGWITAEVTSVIRNPDDTVKLVFVDERGKDISIDTTVQDIKNGKDSLPPLRNPPLLETADDLATLSHLNEPSVLHTIRNRYAQHSIYTYSGIVLIAVNPFQRVTLYGPEIIQAYNGRRRGELEPHLFAIAEDAYTAMSRDGMGQTIIVSGESGAGKTESAKFIMRYLASVNPPNVKSKGRTKISLDESSEVERQILATNPVLEAFGNAKTTRNDNSSRFGKYIQILFDGDQEIVGARIRTYLLERSRVVFQPLTERNYHIFYQLCAGVPLKERKDLGLDTDVSKFQYLSQGGPQSTPIPGIDDAEDFRQTQTALSTIGISVEKQWAVFKLLSALLHLGNVKIAQMRSDSNIDDTDPALQLSTRFLGVSLADFKKWTIKKQITTRSEKIVTSLNAAQATVVRDSVAKFVYACLFEWLVAIVNESLAGEGGEAASRAEMFIGVLDIYGFEHFKKNSFEQFSINYANEKLQQEFNAHVFKLEQEEYVREKINWTFIEFSDNQPCIDVIEGKLGVMALLDEESRLPSGTDASFLQKLHNQLGKPENSKVFKKPRFGNSAFTIAHYALDVTYEVEGFLEKNRDTVPDEHMALLMATKNHFLKEVLDAAFAATKAPEMAPPGSPTVSDSASGGSRRSSIIPDPGRQSLISSIVSSGAKRPGGVARKPTQASIFKASLVNLMDTLDVTNVHYIRCIKPNEQKKAWEFTPQQVLGQLRACGVLETIRISCAGYPSRWTYEEFAERYYMLVHSSEWGPIIQKLELKELCSLILDRTINDPDKYQPGLTKIFFRAGMLAALESLRSGRLNALVTIVQKNMRRRMAVKKYQTLRHATIKIQTWWRGIMARRFVEAVRREVAAIRLQTCVRCFVQRKRFLDIRQGVVRFQARVRGAQARRLFTQSRRIHAVTLLQSLLRGVLARRSHRHDTQRVILIQSCIRRRLARKELKALKTEARSVSKFKEISYRLENKVVELTQNLQKRTEEKKELQSKLAEVEQQFQQMVSRHEETDARARQFQSELQGAQKELTHREELLLAKEDVEKRLEDALAKAAEKEDAIQRLTDTLAYQAAQLETQQKAIDNVPVRNADDSSIILTLKNEVSNLREQVNRANALSALTRGSRGEPTSPTFATGLRVGDVPSPNGAALGVANGRHQRRHSSAGVYAISPVDNRSSADEMMMMAKRSQVSNPRAVSVAYNGEDGLPRFRAPNGLNGFTDTYDPAEEKIRLMQDIKRLDEDVLDGLIRGLKIPAPSTTNPSAVKEILFPANLISLITNEMWKYGLIPESERFLANVMQTIQSHVMSFAGEDSIVPGVFWLSNVHEMLSFIYVAESDMLQGIGPGEENAVRPFEWADYERLVSVVKHDLDSLEYNIYHTWMLETKKRLSKMVIPALIESQSLPGFTTTDGGGRLFNRLLNSNTQPAYSMDDILNLFNKVWKSLKSYYMEESVVQQVVTDLLKLIGVTSFNDLLMRRNFSSWKRAMQIQYNITRIEEWCKSHDMPEGTLQLEHLMQATKLLQLKKATQADIEIIYDVCWMLTPTQIQRMCTNYYVADYENPISPEILRVVASRVMPNDRNDHLLLAPETEEVGPYELPFPREVSGLETYVPAYLNVPHLRRVAALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKK3</accession>
    <name>A0A401GKK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0410640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613592.1">
        <property type="nucleotide sequence ID" value="XM_027757791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKK3"/>
    <dbReference type="FunCoup" id="A0A401GKK3">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKK3"/>
    <dbReference type="GeneID" id="38779596"/>
    <dbReference type="InParanoid" id="A0A401GKK3"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF12">
        <property type="entry name" value="DEFECTIVE IN CULLIN NEDDYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="113"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="357" mass="39549" checksum="6C5DFF543801353F" modified="2019-05-08" version="1">MPPKRKRADESVATTTRTTRSSARAMSVDTAPSVASASTPVNTMSTLSEVEGEADEPPPPKKGRAKKGGTSRAKGKNKIQPTTANEAQSQDVNDNEPSTSNNTKSKKRAPEPYTPAGAASLFSSYTDPDDLNVIGPEGFERLCSDMDISLEGALPLVLAWQMNASEMAKISKDEWQTGMEELQIACLEYLALALHDVEDMLLLNKPPLKHPAVTPARTKKKTVPSEPYNRVRYWKYAADTNKAFSELYSYCFNLAKPAGARNIDMETASAFWSVLVVPQYPVMKEMLEFINDKGTYKGVNKDLWSMILEFCRTIQPDLSNYDADGAWPTMIDNFVEWKTSRSKVDREEPAAPMDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKZ0</accession>
    <name>A0A401GKZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0412280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613754.1">
        <property type="nucleotide sequence ID" value="XM_027757953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKZ0"/>
    <dbReference type="STRING" id="139825.A0A401GKZ0"/>
    <dbReference type="GeneID" id="38779758"/>
    <dbReference type="InParanoid" id="A0A401GKZ0"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="683"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="890" mass="98495" checksum="CDB5DFFC67264E16" modified="2019-05-08" version="1">MPQVPSVSPVTGEPVPPYFIHTTDRHFVDNAGRTLILRGVNLSGSDKAPVDRPSYILEDFWESGETGGESFVGRPLNLDDGSADIHLSRLRGWGFNMLRYVVTWEALEHAGPGKYDSAYMDYTVRVLRKCKEYGFKIYMDPHQDIWSRFSGGSGAPYWTLLACGLDPRHFTATQGAIVHCEYPTPIEVEPATLPPMIWSTNYGRLVSQTLFTLFFAGRDYAPKCIIDGENIQDYLQKHFISAFGALADRIRAAGDLLDECVLGWDSINEPYEGFCGYPDLNAVPTQQTSTLKKGTFPTPAQSMRLGMGQPQTVQNWTFGSMGPKRDGTVTIDPNGWKVWVDPDSEPGGVHPRWGWRRDPGWKLGMCIWAQHGIWDVESGFVMLPDYFRSSPCDPDHDVMFIEDYWRPHWQAFAARMRQSHPEAILFVAPPVFAPPPPITDDELRGRCCYSTHYYDGLTLVTRHWNWFNADALGLLRGKYSSKLPAVKIGESAIRKSLQQQLGILRDDALILGPYPTIIGEIGIPYDMDDKKSYGWTDDGKYKGDYSCQQKALDASLNAADGPNALSYSIWTYCPDHTHPWGDNWNMEDLSIWSPDDLRPRESIRMGMSAASSSKSLVTKSIKGVPIILTASAAPSSLSLATLPLETGAVDGETNNAEITSFGHWENAYDFLTDGARAVKAFCRPFPTAIVGVPKDIQFNVSKAEFKFTVCVRPEDAPRAEGLSAPKSSSSSMTSTAVDDDESEDVLATEIYVPLVHYGSDALVTRFTEQQCDDTSSTPVLDGPLAKDFGPYRSQNVSVSNLSDGTPSYLTPFAPSAAPLALSVHVSDGRWAVEGQTLKWWYGVPAPGAPEREYTITITRAGGVIKTAEETEPTQGLWAEWCSCLNGCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL59</accession>
    <name>A0A401GL59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0412920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613818.1">
        <property type="nucleotide sequence ID" value="XM_027758017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL59"/>
    <dbReference type="FunCoup" id="A0A401GL59">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GL59"/>
    <dbReference type="GeneID" id="38779822"/>
    <dbReference type="InParanoid" id="A0A401GL59"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="3">
        <location>
            <begin position="432"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="670" mass="75950" checksum="6C6CEB43CDB9B29D" modified="2019-05-08" version="1">MSLQKKTMPYVRLGNSGLKVSKIILGTMQYGSSGWQEWVIDDQEKAIEHIKFAYDNGIQTFDTANVYSNGLSEIILGNAIKKLGLPRAEIVVMTKVYGVVAPSYDINLLKSAVPPEEMGLVNQRGLSRKHIFESVKASLKRLQLDYVDLLQCHRFDYETPIEETMQALHDVVQAGYVRYIGMSSCYAYQFQAMQNYAINNRLTPFISMQNHHSLVYREEEREMFPTLKMFGVGAIPWSPLARGILTRPLGEQTKRGETDKPIGRYMRGAGTPEILKRVEELAHKKTISMAQIALAWSMAKEGVTAPIIGTTSLQNLTDIIGAVNVELSQEDIKYLEEPYQPMAIDGHNIFKNVTDRFRISPAFVSSQRSAALRLDIRDLIFMTCNDLRPSSQFHIFHCVSLAGVLRALLNEAKFRIYLLGTVPHAVFYNIRVFRFGLPLILKITRRTTSTEAHALKFLHSTGLNLPIPRLVDSFVRAGCTYTIMSRLPGVPLLNIYDNMEPEQQGVICSEVEAVMKTLWEIKQPADIAGQVMMSASGDGLPDPIFFFEEHSGPFPSALACYAHVSRRTPEEFDGDVDISVQKTLAADPIVWVHTDLRMQNIFINDGHISGVIDWEDSGWYPLTWQIHAMRWWHRGCNGWWRGYWSDDYRFPPVSEHAYDCSCKVLTYSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLR5</accession>
    <name>A0A401GLR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0501900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614056.1">
        <property type="nucleotide sequence ID" value="XM_027758255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLR5"/>
    <dbReference type="STRING" id="139825.A0A401GLR5"/>
    <dbReference type="GeneID" id="38780060"/>
    <dbReference type="InParanoid" id="A0A401GLR5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="910"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="973" mass="103955" checksum="D5CEA824B0DF4ECF" modified="2019-05-08" version="1">MVGERIIHVEAGEDKGKGKSKEKAQGKAAHAMSEEEDGGEGEGEGEEQEGEDDDDADSDEDDDVDKDDDDEMAEDVPGAGQPESIEVDAASPPPPTARPISISPAAPSLQKRKAVITELSEESENEEAALKAKPMKPIEVAKEKGEAPTTSGRAQRAQKRMAQTEVEGSKVSTKKSGKRKAKESSDEEEVPTVKPPKKKHATKEYKSKEFIESEDETPAPPSNLPAKTAGDSNDGVAKMNAPAKPVKQTTRMTATPHVAPKVKAKGKAKAMAKGKATAKAKAKVMVSQKDMWKKTSTRVSDFMWAHATDSLVPCIGCQEKEWPCKLHTTNFGRCLECAARGISCSIAPRNTDGVPLRGNSHTAQREFQEMCAALVVEGKPLPMSPPPYGVKVDSDEPDGAEPLVIEASKCKLPKKTKTCNAATSSSKVKGGEEVEATKQKVTITPYEANAEGEASVEKSSKSKRATKSATATGAVALSNSGEVADSGEVANSGEVSKSGAPAKSGAVAKPGEGKKSGPKPKPVRSQNSGAQDGGEVTRTSVCEPDEVPPAKSVVKEGRQTTTVAMGGHSGPMVPVITRKAKASAPKAAAKMPLAEGDGMEEAARLTMETVQAMAFQTGPAAPLQASSSKRMLTPVTDEPEDAPEYQAEVAEDERASLERPHDDWRHSLLMPHETSAGAAEVAQEVTPSLEISKASKGAKSSTLAKAGHLDEGRRPAKRGTPLDRKAAKKEAEAKRDVKANRLRAVPPTSKAPHLRDIHGEETSQSSNNDCVNCAELQQEFLAHKDGMEVQFQERMADLNTVKAEITAALQRINLPFALQENAWSICEEVKLVMEEFHRPVTIELQESVKLAVADLVAKRHCLPELKEKVNRLEQGVNQTVSQVNVEKLQGELADLRHSMELQAAWSDSMEKKLRSSVAEAIAQASKLEMELALAKEDSMAVATSTLDKVKKVGKEVATVREETSLVVKSLDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLR6</accession>
    <name>A0A401GLR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0501590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614025.1">
        <property type="nucleotide sequence ID" value="XM_027758224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLR6"/>
    <dbReference type="STRING" id="139825.A0A401GLR6"/>
    <dbReference type="GeneID" id="38780029"/>
    <dbReference type="InParanoid" id="A0A401GLR6"/>
    <dbReference type="OrthoDB" id="2789372at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="107"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="392" mass="42804" checksum="24BD2D188AC72412" modified="2019-05-08" version="1">MVNPALIKEAARRASRYTKTSSKPSSSVKPSSPPSPVTNIHPASRVDPKLHNPDVVTLLSVPLRFDFIGYIIDFVAMAVFISKVGLLRARSVNPSTADMLKTPAFIDFVTRLVVATHTDVATVLVALVYVKRWCNSLVVQHLSCEQVFLAAMFVASKYVDEHLCPLELWSDWSGKSEKEIKRVECQFLQAISFDVGIRDEDLLAHYDQVIYRCVTHSLCSSRPLPEAKAVSPPPAYRPQPVLPAPENPTWAALPVPTKEINWSFNGKLAPTAWPSFSPTSSPSSWSSASSSLSFPVSSSSSSSPWSSASSSSYSASSSPSTASSSSVATPHMDESLELPPILGKLNPEPHSQTLPGIWEAIPREYAYNPKPHSQTLPGIWEAIPREYAHLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMK4</accession>
    <name>A0A401GMK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0505060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614370.1">
        <property type="nucleotide sequence ID" value="XM_027758569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMK4"/>
    <dbReference type="STRING" id="139825.A0A401GMK4"/>
    <dbReference type="GeneID" id="38780374"/>
    <dbReference type="InParanoid" id="A0A401GMK4"/>
    <dbReference type="OrthoDB" id="2799175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="271" mass="30182" checksum="18427ACE7B502B2E" modified="2019-05-08" version="1">MTHNATIHDLPDDVLLLIFKAVYSMSRKYPGRDNRSVSIFEADKDDVIWQDEAVTSPSNLFPDSLVPVSRLWKDTLSSVSDFWTRLTIFVDRRPTPLSAIISRLALSGERVLEITLTRRQGSWSGTDLSEQARVNAAIALLSVHMSRWKTLRLDVLHSSSVLRPHVAMHGDAANLVDLRLHSRLKDAPLLAYWSPLVIQATDDSIACLRRTSSRPIAGSISKPDHRLPSLRIDVTSINSFALPGCQSCSWTASSFLLRILTRQSRGCPSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMP6</accession>
    <name>A0A401GMP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0505350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614399.1">
        <property type="nucleotide sequence ID" value="XM_027758598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMP6"/>
    <dbReference type="GeneID" id="38780403"/>
    <dbReference type="InParanoid" id="A0A401GMP6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="167" mass="18598" checksum="37A597CC7352731F" modified="2019-05-08" version="1">MLYRYLGSSACGIQPLLWVSLLLPENHDVIDAGVHRVDDIEGDAQLREGIPRRSFLSGSWVNIGHACRRACAMEADRPEDPGWVDKPGVRASALPRRARTVLREDELERSLEVRGEIGLASRLRSESTERARSAGRPESRKALGRRCLHQGVHCAEELDMTGHLKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN00</accession>
    <name>A0A401GN00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0506270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614485.1">
        <property type="nucleotide sequence ID" value="XM_027758684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN00"/>
    <dbReference type="STRING" id="139825.A0A401GN00"/>
    <dbReference type="GeneID" id="38780489"/>
    <dbReference type="InParanoid" id="A0A401GN00"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019103650" evidence="4">
        <location>
            <begin position="23"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="57"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="623" mass="66796" checksum="BB5929FBA3D997A7" modified="2019-05-08" version="1">MFGFFSKLIFSAFLLLSSGALRLPLEHRGASAISPTVTVNQTNANSYYGLTYVGSIYTVTVHIQGAPYHVALGTGSSDLWVDATLPGIVNTGYNYSSTYADGSPVAGPIVLGNVSLGGYTVEGQALVSSVASNYTVHGIIDGSLGLGPSNYSLIHRILGNTSYDGTPFMNNVFDYGSDQDPYFTVLLARPDFVDSPGGNFTISELVDEYAAISEAPKVPVVADSWLTFLDGIYVNGEFLTGHSGGLNGTPWIAPNANQTFAVVDTGTTTTGAPPYYVDAMYGGVPGAKFVAEFGGYELPCTTKLNISMKFGEAIYPIDPLDAIMPRIASDGSVYCVGSIVYNPKSSGTDFLLGDTFLRNIYALFHYGNWTNKAEYGPYMQFLSITDSNKAWGQFEGLNTLRIMDFKSQVSQISAPISSASSRVVPSIAVSSSLAISSTNIPSTASAASREAALTSPSGVITSNVPLATSSLDPTTHSRSTTLYLPIASSETAENFPESVTHEDPAPTGIRANRMTSLRRPHFTARPEEEPEEHEELLSALVSTTSSPVVDTSQLARNAYIIIGLVIMTLLVLVAIVAKLVLDGRIPRYHAVRNMEYPPAPFNDQPYQPNEDSRVPYNDRARRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GND3</accession>
    <name>A0A401GND3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0507790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614636.1">
        <property type="nucleotide sequence ID" value="XM_027758835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GND3"/>
    <dbReference type="STRING" id="139825.A0A401GND3"/>
    <dbReference type="GeneID" id="38780640"/>
    <dbReference type="InParanoid" id="A0A401GND3"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="923"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="931"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="952" mass="103559" checksum="21E0617906092A0B" modified="2019-05-08" version="1">MAWSSKNLMSGESSVPLDLHVLAAVLSSLPHLRKLRLIQLTFTNGCQSSPPQTAFALEELIVQQTHKERECTFKTLGVLSLFTEVRRLCLQDSSRLLGPQNDHTRELRVDGELSRSRKPQVYSLTFRSIYDMVYYWRTLIRSSSSQTLGSVGATCLAWDEIEAFRDLLDEVGHCVLSVELDVLVSARKNETYPGFDLSDCTSVRSLVLGLNLTSSDNYAWTVVAEALRHTTNTPLRDITFRVTVLYLFSELNFLAVLKRLDTVVMDQALNIFENLETVTFEFSWYSMQMAHAFHSSSRPADDGKMVEYLLTRIACDHVTSLVIVGYNADVTPVFTTFLIVTDDPHTVFVCMVSLTSAATPSHVEGEIEEGAYDEEDYDEEYGEGDEEYDDGDDFDAEAEEEMARRLQEQLRADIAKAQLEAAAANAAHSTTPAVLRPTLPALHSAKSSPHSMTKKKEAAIVTMKTILAFGAKDPLVHASLSASAVSAAGDTSVLDMFDYCVASGTLSKKLAKPLSAVVVSLAKSDVLFASLRNSDASALQLSKGKRQREELDTAETGDSRAHKRIAIDQPDLKYRIAEAVQAISRSLSSTTSSSGLQFPDPGLVASIQVPLHQVFLFAVTSSPRGHGGRSPALQELGSLIQMLGVLTGVPIGTGPAPTHPAMYSPGFGAPPDLGTAVYPCTASACTKTFHRLYSLRAHQRLHTLIERPFRCKHCPASFVRNHDLKRHARLHEKKAWLCNGCGKVFSRRDAIKRHKDSRGRGVGKSEGDGVCAYAEIEEVEVEKPEGEEEASRRAKLWNGIADAQDFRTAISEEGSFEEGEVDPRVMEEAQDLVLQLLGLLRSYVGRGQGPAVVPPGPSGFTANVPPATLASVMAGARPSATAQAPVSTSASSSTTLPSLSLSWLSHEQTKMLEQAIAQAASAAQAQAEAEAALEEGGDGLNDEDDEGCEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNN9</accession>
    <name>A0A401GNN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">SCP_0509040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNN9"/>
    <dbReference type="FunCoup" id="A0A401GNN9">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNN9"/>
    <dbReference type="InParanoid" id="A0A401GNN9"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE83847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="95" mass="10499" checksum="258CFA6B210F9CD1" modified="2019-05-08" version="1">MASLQGYVDHRVLLILQDGRAIVGVMAGYDQKSNVVLSDSKERVYSIEEGVEEIPLGLYLVKGDQIVLIGELDDAIEQTVDLSTIRAEPLPPIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNP4</accession>
    <name>A0A401GNP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0508790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614735.1">
        <property type="nucleotide sequence ID" value="XM_027758934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNP4"/>
    <dbReference type="GeneID" id="38780739"/>
    <dbReference type="InParanoid" id="A0A401GNP4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="59" mass="6727" checksum="F120B5D9AB049FC4" modified="2019-05-08" version="1">MKAFVFWRVRVLESSRSGESEFSPGRLDQADMLAPQAEVFTLARVRIGKLLGDRVCGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP43</accession>
    <name>A0A401GP43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0510540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614908.1">
        <property type="nucleotide sequence ID" value="XM_027759107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP43"/>
    <dbReference type="GeneID" id="38780912"/>
    <dbReference type="InParanoid" id="A0A401GP43"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112742" checksum="D1BF75B4FF01A355" modified="2019-05-08" version="1">MPARFVILTEHQPILSEKLRSYDTADAKGRKTLVQSLRQKLKTQFVDTSNYDDIIVETKIREWLNNHTRHAQEKVTKKRMHISGKPNAFKVWDALERDKVTEAARALAADKGCNVSKVWRVARSAEWAKLSEEEQKVYEEKVESWRNGTLDDKTKMKLREQRMMQYLKKFAKTMWDTMGIRMAFMLAYPKEAGSLKVEMVEVNHAITNGTPFRAYPGWLHAYQPLAKVFSEWAKGEYGVTETTVTVKKTPADCMRAMDKIQLTANGFPLLPSVPEGMAEAPLKVMKVQVRDFMNHHYALAKGVRNCKSPWTKLNSIDDINEVIPAEMLPENFQWIDPSKMTSVPVRALLDHWRARQEEHGPEQTMRFTQYFNKDGEAAPAKYDPLPPLDGSAQALEEGSEHEVQEALTPKKAGKAKKKGKPVRKVTGKAASKATKGKAAPGGAKGGGRKGKMKDAYDSEDDARSSQDSDQSSPDIPSMASEEDTASDEDSGDGESVIANKAKGKAVTTTNGRKANNGGAPQASGSGGAKTKAKRGLQDLPLGELHRFDTEETDEAWSELKPSTKELRLELQGRAPHLTGGSTVGSTVPHLVKRRDVFLATLSIEPRYQDMLKQVKIATVPQVYRFARYDPIPWSEWSYGQRYLPPSFHAVDNFDIIENWLGDKPWLTKYRFLHPQGVQQSALVIGMALRDLTRSQFIEEGEPTNLPDYVVNSAISFDAVEQLLRCCEIITLDMVEGNVTHAMVKPVSKPAIRGAPQGGDGLGGQEEQEGDASARTHDGAATAAKVHKAHQPAPMADKPIIPSGGDEGPRQETGGGASDDGEEDDAHLSVPSSGAERPPPPPFIPKTRKAAATEDRPSGQAKALQGRSITDALQSNIPGRITRSQRQAMDESPAKNTRSQHPLGAVKDLKKLPDPKRKRQPARPEPDGEDSSGEDNPPPRKRGRGTRDELVVASPRKKNVRAEDSDDGDKPPAKRRRALPQTPEVKDKGETKLKPVRLGKAAAKVKESGQVGAGRKTRSGGTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPE4</accession>
    <name>A0A401GPE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0600890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615024.1">
        <property type="nucleotide sequence ID" value="XM_027759223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPE4"/>
    <dbReference type="GeneID" id="38781028"/>
    <dbReference type="InParanoid" id="A0A401GPE4"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11544" checksum="5EAD31B5248A89F0" modified="2019-05-08" version="1">MLSTTIRVAERYGPPFTGSRAPFDSSDPLVFTHHNLNMRNFPLDRLGKVRLLNFGWPGFHPPVFEYYGMRQAAINDRSPKSCMYSIPFMAGIYFKERLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPL6</accession>
    <name>A0A401GPL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615094.1">
        <property type="nucleotide sequence ID" value="XM_027759293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPL6"/>
    <dbReference type="STRING" id="139825.A0A401GPL6"/>
    <dbReference type="GeneID" id="38781098"/>
    <dbReference type="InParanoid" id="A0A401GPL6"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062064">
        <property type="term" value="F:box C/D methylation guide snoRNP complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674:SF1">
        <property type="entry name" value="NOP PROTEIN CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28674">
        <property type="entry name" value="SIMILAR TO DNA SEGMENT, CHR 10, WAYNE STATE UNIVERSITY 102,-EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="170" mass="18579" checksum="0357EBAED4E35318" modified="2019-05-08" version="1">MYDIFQRLDTSSGPRPAESFTKFDFGDRRTFPMGPPSELLSRVQAFLPEIAASNADIARQAEEDPNGVDIEHLEDSEQYIEMNLGLGVFETRKPPDGSVPMDTDADEDKSSDSSSTDSDSDSDSDSDSSGTSSGSSSEVDAEDDIEAVLPRPMKPLPKRRRLQIVVLNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPR2</accession>
    <name>A0A401GPR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615121.1">
        <property type="nucleotide sequence ID" value="XM_027759320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPR2"/>
    <dbReference type="STRING" id="139825.A0A401GPR2"/>
    <dbReference type="GeneID" id="38781125"/>
    <dbReference type="InParanoid" id="A0A401GPR2"/>
    <dbReference type="OrthoDB" id="3061698at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="367" mass="39492" checksum="0C11C390BF737657" modified="2019-05-08" version="1">MAKLPRAKNPFTPTMRRFLSDVFKPAPALGKRARSSSRSHSSSELPNPAPGPAPACVALQNEDPDTDTVVITALHAVPFCCHADLLAMPRAHLLAVARALNAALPHALRIDAGPARSDARIRNAIEILVGLRLSVPPAPRANRSHGWADDERGVLRSPTSPLANRSRSESSLGVLHEEDESGAGYADGRAHKRRRIVPGPPEDPNMILRDLELDTVDRRVTRSQSTRAAADINSPTPVGRRVIRTRSERLPATRPMIQIQGHPNITLTRGRSAGRGYLRSRSAALARTSTPKRMREECETGEVEGPRSNAMTSTPGAGEADSGRVKVGKGVVMEIGPCEDTAEMTFGIHGMTIGPAESSEDMDLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPS2</accession>
    <name>A0A401GPS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0601270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615062.1">
        <property type="nucleotide sequence ID" value="XM_027759261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPS2"/>
    <dbReference type="GeneID" id="38781066"/>
    <dbReference type="InParanoid" id="A0A401GPS2"/>
    <dbReference type="OrthoDB" id="3058546at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="228" mass="25005" checksum="AAF6AD7A93039E46" modified="2019-05-08" version="1">MIGQSGFQASPDATLPQQKMEDVLGKMQLPFGVLLAHKYCIGTVELNGLDNVLHAAAEAMVQRSNAQVHFLPVLTKLDGSALLSGDGDDYISVTAPVYPLTQAHVEALLASVADETEFSDAFVEFNNDRTYVDLKSYPIYHRAVPPPKVIIDVPSAEGWLTGLTSVPFYSVDFAKSSIVWKKRGEGGAHYTGNEAKPWTEDSIYLSYAMVMLSNDPAPKDLKRKRDQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ27</accession>
    <name>A0A401GQ27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0602380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615173.1">
        <property type="nucleotide sequence ID" value="XM_027759372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ27"/>
    <dbReference type="STRING" id="139825.A0A401GQ27"/>
    <dbReference type="GeneID" id="38781177"/>
    <dbReference type="InParanoid" id="A0A401GQ27"/>
    <dbReference type="OrthoDB" id="2794913at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="674" mass="73992" checksum="7F04225FC729B826" modified="2019-05-08" version="1">MRSQEIGPVSKWVDDHVFLRILRKFLSEYNQKRAAWRESIEALGGRHHTGGQHWFGGGLLSDGRTDEFDDDMAWPLLDLSQQSSCPPKDAKFTYYIADIDTISTRLSIPWKLEKDIPFSSCFPFTGFIWDLEARTVAIPLAKAAKYLAAIEEWSLLRTHTLQEVQKLHGKLLHASLVVPAGCAYLTNLEAMLGIFSDSPFKPHTPPPQELPEISYGGQVRYPNPSSHGPSQGLAYWLTLVPSPMQAQILASASSLGATGMHGVSSQVETKTGEISDGLKLSVLNSSYASSFASPLPTITSRSMETTRKSSKAGGMAVAAMHKSMPSSVVSIPFSSPPAVRSTLSTSQVQPILLINHHVEATLQPDISFPPSRYLPSSTPSSLTSMHPQLVLNFTFTDKNSTLALLPRLTSTAQQWSRLQSTLSEIGRPMNSSGGTRTGMTKHHMDVPLPPRDENLSDPQPYRTGLIPRPSPLCPHCLARHRLLLWRPPSSRRPIDHNGMPVSLSNADVQRIQDVAAFAWSDNTTENYGAGLLVFHVACDVKLIPEEQRAPASSILMSSFITTLAGAYSGKTIAGYFYGVRAWHILHGLPWLMNKAETDILLKSADVLTPSTSKCTSRQPLMTEQLLHLHGQFKLSDPFDTAVWACLTTAFYAVARIGEVTVPKLTAFDGARHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ30</accession>
    <name>A0A401GQ30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0603040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615239.1">
        <property type="nucleotide sequence ID" value="XM_027759438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ30"/>
    <dbReference type="GeneID" id="38781243"/>
    <dbReference type="InParanoid" id="A0A401GQ30"/>
    <dbReference type="OrthoDB" id="2750871at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="138"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="850" mass="95714" checksum="F90A8C9D89505342" modified="2019-05-08" version="1">MGRPLTCTDRCRNGHQRAPFHRIEHWQGQYFEPASLYWVGVCIHLGHGGDPCPLGTFTAHNNPAPVVAPGSDFWNVSNEDVNAHDGEVSDDGEVPFNFAPLAGTLDSEARQTDDAPDPTWEEDVPPVLSRPPRRDSYGNRIIVIVDISGVHHIGVDWCQCEMAVERDMQLLQMGLYPGTVKDPHTAFTFAVLNDFLLENKECKTAALNYYSKLKWVTSNAFPGTVPDRYRKLMRVSHQWCQFKYRKWHGFSHDALRPVEKGGLAIFCPACPQPGLNLPFDWQADPVAEHMKMKHPEENVALSDGQAFMVGQEDYKAHLAVTMESHQRSTCHEHRAVNQANVDRANLDATGIGATACARHGFFIPHTVVDFQKGERQMNMDYSLSNALLTLTGITLVLVMYDIMCQYGVHVRKRFRHSAYLRMPFELKVDQGIGLFHVHGHQDCCFQRFSPNFIVGTGMVDGEVIETLWVPTNEVSGSTRGMTRAHRQEVLDDHMNDSNWKKTTHMVPTLMTKWKRVLLGFPRSKESFEALSAPTNEDVLEAWQKEYDDAMEARQNDPKIMDTFDVQLMKAPGKDLTQLRLAGEESAKGLEKGTAGWLSTGLKIQEAQLMLVNDIRKAGENMSVAEDLKTLERRQRLEVSILTFQRRSEKFMGRLEDTPAMEDCDDGALWDSLDENPFQIHPEDAEYGEDAIPPERASLNLPSQIGFVAAVANGLQTLAAQELELRKGLMNDILHELRMAFGLKSYLYCKRVRPANSVGTMTRAQAEVHTADQTILACARLYSANRRAIMRLGTTDEDLALYRPLDKKDLHVKTAVIEASTSGLRNVNLAWFWTVDVAGDRGSSEWMDECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ32</accession>
    <name>A0A401GQ32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615254.1">
        <property type="nucleotide sequence ID" value="XM_027759453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ32"/>
    <dbReference type="GeneID" id="38781258"/>
    <dbReference type="InParanoid" id="A0A401GQ32"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="166" mass="18983" checksum="E69FB6C4E0D05FD1" modified="2019-05-08" version="1">MSPDPDKHSEDMNYYFQSAEQDRLMAEFDQDLTDAWRESERIVETDFHIYSAMQDDIRFSELATQDDKKPLQPIQLDAEAQPATPPTPTVHCWNDGPPPEVESSSSARDVAALSPPSTNGPAYDEVNWIPYHKHMMLKDDDNNPLVIQSLVYVTTFAYVTHHIMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ74</accession>
    <name>A0A401GQ74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615265.1">
        <property type="nucleotide sequence ID" value="XM_027759464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ74"/>
    <dbReference type="GeneID" id="38781269"/>
    <dbReference type="InParanoid" id="A0A401GQ74"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="244" mass="27384" checksum="9D623CB8F177EA6D" modified="2019-05-08" version="1">MLRCLQLLAPPVYRPFHLLRDLAPVGGQFKNQGLGAPMQKSVAPSTAANRFPLIPSHKSNKDTTRAPGKCSSLRSRLTPISTLQPLVQPHFSRENIDTATAEFSFSVRGVGRTLTHAAQRNRRRKSSCRLIGPATDGSPHRPAANSQRRRSSSLIFVTANLTCHVSWTTLRESRRFIRVPAKSRIVSKPLRLYSEHFLALDPYRVWRCSHDVILERGEAPKFIHIFTLPVAVRRLVMARLAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQD4</accession>
    <name>A0A401GQD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0604120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615346.1">
        <property type="nucleotide sequence ID" value="XM_027759545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQD4"/>
    <dbReference type="GeneID" id="38781350"/>
    <dbReference type="InParanoid" id="A0A401GQD4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="140" mass="15855" checksum="12159648DBE293D4" modified="2019-05-08" version="1">MHFVHSQPKRKTFYGKWRPPYYQAKTCDEQMFFARGKSVGTMTKRSMADKSRYVQFSGQTTVRILSPPSSSLVTPHVKLSASDENPETKLDALAAYGQNKPRREKVKLPSVLSEEFAGVPFRGFAPTFHSLPMTFRALPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQQ3</accession>
    <name>A0A401GQQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme E2 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0604690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615403.1">
        <property type="nucleotide sequence ID" value="XM_027759602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQQ3"/>
    <dbReference type="FunCoup" id="A0A401GQQ3">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQQ3"/>
    <dbReference type="GeneID" id="38781407"/>
    <dbReference type="InParanoid" id="A0A401GQQ3"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="2"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="176" mass="19611" checksum="A099C028F890C293" modified="2019-05-08" version="1">MALPKRIIKETERLVADPAPGISAAPHEDNLRYFDVTIQGPDGSPFQNGVFRLELFLPEEYPMSPPKVRFLTKIYHPNIGKSFTRGETLGAKTHSSHSQTNLALTEAVDVVRVDSSTTDKWSPALQIRTVLLSIQALLSAPNPDDPLATDVAKHYKENEKDAQRVSREWTEKYASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQR7</accession>
    <name>A0A401GQR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0605240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615458.1">
        <property type="nucleotide sequence ID" value="XM_027759657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQR7"/>
    <dbReference type="STRING" id="139825.A0A401GQR7"/>
    <dbReference type="GeneID" id="38781462"/>
    <dbReference type="InParanoid" id="A0A401GQR7"/>
    <dbReference type="OrthoDB" id="2623028at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="447" mass="49552" checksum="4A4A53CFFF4C8906" modified="2019-05-08" version="1">MESALGPGQRRLLGELGQLTRLFAFPLVRYIPAEASGDKFQSVIWESSDLPDVPLEDHNSRCYYCLDDYEPPRKNSVQIAQVPETAAPEPLTQFPCGHVLHQDCAAAWMREHSECFLCKADILGPTDLPYPTDCLKENSDWSAVSNLIRSQHGIARRVVEVDLLYTMPAEPCDFAYFSADGQYLAVGGRYAGGHGRVIRTMTASKICTFTDDYLSACCFSPDETTLVTGNSRGGIKIWNIQVADGHAEKTTTLVGHSATVRSMQFLDGSSSLASLAADETLHIWDVRSGHMIQTIQLQGMRSLRLACHSGRIVVGSSDGMIDLWDVDTGSLLNRWRGHNDPITNLVFTPDGTGLVSSAWSTDPLKCWDMTAILERYMASPAIFDNHRGTEEDISSVFTTRTFTGTEYPRSVTISREGHWLASCDWEEVFLWDAQTGEMQFVLRVGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQT3</accession>
    <name>A0A401GQT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0605670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615501.1">
        <property type="nucleotide sequence ID" value="XM_027759700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQT3"/>
    <dbReference type="GeneID" id="38781505"/>
    <dbReference type="InParanoid" id="A0A401GQT3"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="201"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="829" mass="93401" checksum="C836516902E029C2" modified="2019-05-08" version="1">MVATPLSKNDPKYNVWQQKDFDHHDIRRHYRQYANSAQGFILGPMPVDEFLEFLPETDMSNMPRPVNAFNKVPAEARTEQQIYKPLIAAINGTRTRSRKSQRRCPGFTFKDTATSGAELGDIGSMNAHVSCYSQDINDSHLTSAGPLGCADLYIDVQRHPGLDPFTDPGPEDDRSEHAFFQTPGDHRARKEAEEAFGRNVACATEACSRQHRAFYFSISLAGSRARFLRWDRCGVIASESFDIRVQPEHLCEFLWRYAHASSSQRGYDVSVEAATREEEELFRDCIERHVKFQLDPDDEELVVAMEEHYQPGAVVAINVVDEGSPDCVAHRLLVSRPVVSPVSWTGKGTRGFWAVTAGSPRGEVVFLKDTWRHNVEHMKEGNILADLHSAGVPNIPRLVHHGDVWDQLPVSSGRGDGESDLTYTRDETTVLQNTQTDRFRHATWVCTGGENHKLPPPLVHYRLVLGTVGYPLQRFRGTKELLHATYDAYEAMVAAFHAEPGKRRLHRDISVGNIILSKDPHSGENIRRGYLIDWESSCLITEGEACDGLKTGTVQFMSQRLLSSSSESVSHTFQDDMESMLWVVLYSSLLWLGHDKSRDALVAILFQLFDRTWIDSDGILNGGDAKFSNQFSQEFTRRIHFSNPVFREWLDAVIKFNSSHVLQRPQDMESAMVWENPEMFGKFWKDFLSTHELSNDDRFPRKLYPRGTTWRRSSSSTLSSTSSTSGTAHPVPVVLPSRKRKAADAIVADLDRTTNSRVPAVPRGNYTGPITRSMAKRRQVEGQGQGVVAGGSDLPIQPQWSPRRLRPRPAKVDNTSLARQGRKVGQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQU4</accession>
    <name>A0A401GQU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0605610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615495.1">
        <property type="nucleotide sequence ID" value="XM_027759694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQU4"/>
    <dbReference type="GeneID" id="38781499"/>
    <dbReference type="InParanoid" id="A0A401GQU4"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="832" mass="93814" checksum="333B977592E1B90E" modified="2019-05-08" version="1">MVATPLAKKDPKYNVWQQPEDDVDRKDIRRRYRQYADSAQGFILGPMPVDEFLEFLPETDMSNMPRPVNAFNKVPAEARTEQQIYKPLIAAINGTRTRSRKSQRRCPGFTFKDTATSGAELGDIGSMNAHVSCYSQDINDSHLTSAGPLGCADLYIDVQRHPGLDPFTDPGPEDDRSEHAFFQTPGDHRARKEAEEAFGRNVACATEACSRQHRAFYFSISLAGSRARFLRWDRCGVIASESFDIRVQPEHLCEFLWRYAHASSSQRGYDVSVEAATREEEELFRDCIERHVKFQLDPDDEELVVAMEEHYQPGAVVAINVVDEGSPDCVAHRLLVSRPVVSPVSWTGKGTRGFWAVTAGSPRGEVVFLKDTWRHNVEHMKEGNILADLHSAGVPNIPRLVHHGDVWDQLPVSSGRVDSESDLTYTRDETTVLQYTQTDRFRRAAWVCTGGENHKLPPPLVHYRLVLGTVGYPLQRFRGTKELLHATYDAYEAMVAAFHAEPGKRRLHRDISVGNLILSKDPHSGENIRRGYLIDWESSCLVTEEGSACDHSRTGTIQFMSMRLLTSGESVSHTFQDDMESMLWVVLYSSLLWLGHDHPPNMVVTYLFELFDHTWINPEGVLKGGSGKLSNQVGQDFTDRIQFSNPAFREWLDAVIKFNSSHIVPHLHDMESAMVWKSPELLGKFWKDFLSTHDLSNDDRFPRKLYPRGTTWRRSSSSTLSSTSSNSGTTHPAPVALPSRKRKAADDTVAADSERTTNSRVPAVPRGSCTGPTTRSMAKRRQVECQGRGVAAGDFDSPIQPQWSPRRLKPRPAKIDNTSLARRDRKVRRSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQY0</accession>
    <name>A0A401GQY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S53 activation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0605490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615483.1">
        <property type="nucleotide sequence ID" value="XM_027759682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQY0"/>
    <dbReference type="STRING" id="139825.A0A401GQY0"/>
    <dbReference type="GeneID" id="38781487"/>
    <dbReference type="InParanoid" id="A0A401GQY0"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S53 activation" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11124" checksum="6E66A8E9471143E1" modified="2019-05-08" version="1">MQSIPTGLEQALYDVSTLPCANYRKYLTKEAAEFVSPAAESLAAVNNWLQANNIDAAVLTPAGDWISFSVPVSQETICSIPSSLHSYVRPKAYGAFGRSRVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR73</accession>
    <name>A0A401GR73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615629.1">
        <property type="nucleotide sequence ID" value="XM_027759828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR73"/>
    <dbReference type="GeneID" id="38781633"/>
    <dbReference type="InParanoid" id="A0A401GR73"/>
    <dbReference type="OrthoDB" id="2686566at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="152" mass="16933" checksum="B73FD323EE400100" modified="2019-05-08" version="1">MGYRLQLCIVNWPDGITSPGPDFTYKSLQAADLAAIVDPYIRRVKDPDSTDMVVDIIPWSDNSIALPDGHRDKASVALVQSMKGRKLRVLRDSPDYLKALAPAIKHRRPSKRAFEPVDLSNLDEHLEDGLSADEDVSHRPAPRHVAEQRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRF6</accession>
    <name>A0A401GRF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposable element Tcb2 transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0602820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615217.1">
        <property type="nucleotide sequence ID" value="XM_027759416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRF6"/>
    <dbReference type="STRING" id="139825.A0A401GRF6"/>
    <dbReference type="GeneID" id="38781221"/>
    <dbReference type="InParanoid" id="A0A401GRF6"/>
    <dbReference type="OrthoDB" id="2753252at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:DNA transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055247">
        <property type="entry name" value="InsJ-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052338">
        <property type="entry name" value="Transposase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002492">
        <property type="entry name" value="Transposase_Tc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022:SF135">
        <property type="entry name" value="SI:DKEY-77F5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23022">
        <property type="entry name" value="TRANSPOSABLE ELEMENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13518">
        <property type="entry name" value="HTH_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01498">
        <property type="entry name" value="HTH_Tnp_Tc3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insertion element IS150 protein InsJ-like helix-turn-helix" evidence="3">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Transposase Tc1-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="2">
        <location>
            <begin position="142"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38877" checksum="7F4E4FE14AD5AA97" modified="2019-05-08" version="1">MVYTTPTKSGRIVEQYRSGRSSRAVAKEFHVSPQTVCSLAKKFKENGNIYPLPKPGRPCKLTAQDADFAVLQLDRGRAENVADLQRSYFPNVGPKTLRRAMRTNGLISAVRRRVPFLTKKHRRARLIWARALQGWTEREWERIIFSDESKFNLIHSDGRAWCWRRVGDGYQDRYTQKTKKFGGGSVMVWGCITPEGVGRLHRITGIMRAVDYVQILEQDLLGTLHNYHMNPHHYFFQQDNDPKHSSHLRSWVDESGLHSLPWPAQSPDMNLIEHVWDILDRRVRARNPQPSSVDQLWDALEEEWSRISSAQVQKLYGSMPNRVAELKKAKGGNTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSL8</accession>
    <name>A0A401GSL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616144.1">
        <property type="nucleotide sequence ID" value="XM_027760343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSL8"/>
    <dbReference type="STRING" id="139825.A0A401GSL8"/>
    <dbReference type="GeneID" id="38782148"/>
    <dbReference type="InParanoid" id="A0A401GSL8"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="337" mass="38081" checksum="45788448FCE39D18" modified="2019-05-08" version="1">MCRWFAYLSKSEPCLLEDVLIVPAHSLAKQVHDHYLPMLAYYEPDSNARDTDKEIKLRNSLYNLDGLGMAWYTTSRAEFGECDGPHPAVYKVLRQPMNDPAFLSVCANTSTLAVFAHIRAASGGTAITEYNNHPFQFGRWLFMHNGVIAHFSTIKRQLIAEISDEALQLVRGTTDSEHLAALFFTYLEEKKGATAWGTSHTLEDVKHTLEKAISKVLEIQKQVVAQPDASSLNIAITDGTQLLCIRFRNHPTEHPPSLYFSTQAGVALNRKYPGHPDMEWTHNSQTLKDDHEHGEHIIVASEPTTFKKQDWELLKKNECIMVDPNMVLTRSSVEIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSR7</accession>
    <name>A0A401GSR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0704650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616191.1">
        <property type="nucleotide sequence ID" value="XM_027760390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSR7"/>
    <dbReference type="FunCoup" id="A0A401GSR7">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSR7"/>
    <dbReference type="GeneID" id="38782195"/>
    <dbReference type="InParanoid" id="A0A401GSR7"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17978">
        <property type="entry name" value="DEXHc_DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="103"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="302"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE85278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="735" mass="81694" checksum="C87FB7FF55B78A11" modified="2019-05-08" version="1">MPKIGILRGISKKPPTSHVQKHSKLNDCAWMDVSDDESMHVRHSAKSPRTPLRNLQGSPYPRREPKNPRRSTGDGRNADHGKVTSIQEQRRQLPIATGKDALVDEIRNNDVTILVGETGSGKTTQVPQYLLEAGLAGEGMIGVTQPRKVAATSLAVRVAAEQNVSVGSLIGYSVRFSEASSKDTRIKYVTDGMLVRELLGDSLLSQYSVVIVDEAHERTLRTDLLLTNLKAIQKVRNSVDRKGKKPVSKLNPLKIVIMSATLDAEKFSVFFNKARIVYVKGRQHPVTIYHTAVGQPDYVDAALRTFFQIHVDQPSGDVLIFLPGQEDIESLEKSIKLYVQRLPKNSPRVTLCPMYAALPPSQQARIFSTTPPDSRKCILATNIAETSVTIPGVKYVIDTGKCKEKRYIARDTGTGFDTLLTRDITKSSAMQRAGRAGREGAGFCFRLYTEEAFDAMPMSVEPEIRRCTLTSSLLQLKCINQDLEELDFMDKPDQETIAAALKTLWLLGALDNKKALTPLGREMAHFPLEPILARIIVASKGHSCMLEVIDIVSVLSASSKLFFDSTDERDAALEARRKFRHPSGDHMTILNVVKSYQEIVALETKAGCKDWCRRHFLNYRCLVEAIDIRDQLREVCSRLKMDWHTSCGDNEQKIMKSLVSGLVQHTAFLQPDGSYKQLMGPSIVKIHPSSSLCDKKVPAIVYDALVYTSHIFARGVSAVPRSYIAEVPVLNQRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSZ8</accession>
    <name>A0A401GSZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0704870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616213.1">
        <property type="nucleotide sequence ID" value="XM_027760412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSZ8"/>
    <dbReference type="GeneID" id="38782217"/>
    <dbReference type="InParanoid" id="A0A401GSZ8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019565907" evidence="2">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="15965" checksum="9248FE7D84B1A2D9" modified="2019-05-08" version="1">MHTHQTLAVILCLLLLSTDGHTPRKRHLDIDPWQSLSIHPIVPRDSDSFVRVVPAVQKRSTTCVRSEKIRRSLLPPPSTRRRAAVCRNGPTAPAAVGAAPSSTGAAAGAAPSNGNAGGVGPSGKSGDDGAGSSNAGSSANFLVNRTLSSLVWIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTU7</accession>
    <name>A0A401GTU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616516.1">
        <property type="nucleotide sequence ID" value="XM_027760715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTU7"/>
    <dbReference type="STRING" id="139825.A0A401GTU7"/>
    <dbReference type="GeneID" id="38782520"/>
    <dbReference type="InParanoid" id="A0A401GTU7"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="67793" checksum="B2DE77C5A4ACF8BF" modified="2019-05-08" version="1">MSILVLPPEVIEAIAVNTVVAGFPTTIAAFAQTCRTIRAIIYNTSDHQLWREVFLAVFDDPRACHYIDTADFDWGSEFKRRTWAAGYLCTHTCLLPVQKPHALRSRTTAIEHPELPDTSPAENARLLYTLLSVIKTSAPASSPHGFEDLHSLTHAHNLPYTHQHTPLIVLPAFHGPSLNVEWLRTTLERGLPPSIIAKVSGEFFDETWLVTPEAQALCQLICCTGFMPVPQLQEEPESGSTSSSTKRKAKRKSRKKANQAPLDMSVDAQQKRARYRARERVYDLNYLKRRRHWGPFRPVMPSALPPPSSSSPSADANPDRNVLYTMLDPSDLDSSSSDSDFVPMDDPRRQSSATPPSEPEPDFSAPLRKRREPTAAQLLPDWTWLAAARIICEANMRTQGPAQDNVEELCQWDGVREYAWIHTTEGKDPAEEDVTAQGKATQVRDEEVQGWDWAGVEGVWRRCVSWLDYTDLINHNNVGEFDDPDLEEAMLIVPLRLRIVGYGPPAIPTHVDRPTIKVEGEMGGAGWVGVPEVNDDVRKIHGTVSTIADGSIRWSLYSSHEDSNTDQWVSEAIQVGGVGSAMGVLGMWTGAFHEDDDPLGAFWAWRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUF7</accession>
    <name>A0A401GUF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616277.1">
        <property type="nucleotide sequence ID" value="XM_027760476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUF7"/>
    <dbReference type="GeneID" id="38782281"/>
    <dbReference type="InParanoid" id="A0A401GUF7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12733" checksum="219B06E022BD7C7B" modified="2019-05-08" version="1">MTHTHQQSARLAAARQEKQALAGHEDIDTALQGPTNFSRVGRYARESTLMAQEGPALNEGNQTAPSVMLTKLAPMYVNIAAHPPLAALIPSQAPMTTQLLQQSMALQPVDAKHARLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWN1</accession>
    <name>A0A401GWN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rho-type GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0904580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617492.1">
        <property type="nucleotide sequence ID" value="XM_027761691.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GWN1">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWN1"/>
    <dbReference type="GeneID" id="38783496"/>
    <dbReference type="InParanoid" id="A0A401GWN1"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="193"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="256"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="662"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1251"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1309"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE86579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1405" mass="154596" checksum="6B40609ECA046FB6" modified="2019-05-08" version="1">MSAASDHYRLYQAATSPADHAPESALAYMASGDDANLHPDRNASSPRLPPSPNPGAAASGSHPPERPPPPTRASTVSSSHNYDQRRQRPDDHPHARSEDLNHTTSRASNDPGVPDLSSQTSSRSQTFLSASRPTTPAGSANNQASSSDLSEFPKARPGSVHSESSQGSESSTPGGSVPGGTSTTHTSTSIASTPCSACGKAMQGAFVRALGTVYHLQCFKCMDCGTVVASKFFPIDGPDGRQHPLCERDYFRRLNLICAKCGMALRGSYITACNKKFHVEHFTCSVCPTLFGPQDSYYEHEGDVYCHYHYSTRFATKCAGCNSAILKQVLHDQQGDLSTSTIVPLRMLTMAPSLQFWNVKVVSRRPIPAYTEEGDGNSTEPLYAEEERRETATTLKDKQVRMEQQVYRIWTVLSAFEESSAACISDMLRQVSNGQYSEAIRMAEKFILHVEVLFATIDDLEWHFARLKLKGMSHVREARMLCRKTVDLFTLLSHTQETGTRRMGMTQELLALVTGLAHYLKILIRIALTGALKLEREQDVREAITSFLDKLHMLAIQAGNPSAKRMMKRANGEFMGPSESGGNAGTQGVTYGFKSLAPENAGESPFANGPRDPALAKVSVVNPPSDLCVKCNLTVEEDCVRLGTYQRWHSHCVQCGTCGKAAAAPVPKEPPPPKSPDDKDKEKDTPKLSTARRPPANVSMFVYEVDTMKDTTSFGTVPTVIFCTDHGHGGCRSGFQTVSRLEQYAFLLNVALRRLYALLKKRGVVQLTPAPQGQTPRDHEEDLYRNSGEINRLKSVHLDRKLSATARVPKRSTIVESPTGKVAQPTDVMHSQRSQDVRTAQQMQPKHLKSFQPPTRPPHPGSLGLIDTNQQGQVIRPAFARNNTEVMIVDDSAPTSPAGGVDEGTVAGVEDGITLADIPQIVEAAQAREQHRSLPRESLIPFIAELNPVELAIVKHCAVLVLMRSPLREQMDLDEILELVEIKKSSFWNKLFKQGSDKKNVKKKGVFGVPLELLVEREGADSLLGASRVAMKIPSFVDDVVSAMRQMDMSVEGIFRRNGNIRRLKELTEAIDRDPSSVDLTQDNPVQLAALLKKFFRELPDPLMTYKLHRLFIASQGFPNEADRTRLLHMVSLILPKAHRDTMEVLFVFLKWVASFAHMDAETGSKMDLSNLATVICPSILYSRGRDAVRDESFGAIRVVTALLENQDEFYCVPQEFLPILHDQDYFANSMDLPSKEFLKKCDTYMRLKANGRTPGLTSPVSGSAPFPPNTPRSEDMRSFPPRAQSNHQYVDRPILGSPSPSENLIRNGQGQPTRQQTLPPLQHSSFSHSAPGGTSSSSSLQAAIHAPQPRAPEVQPSTSEWVPPERQPFIGQVPSRPSSRPNSFVLPRSSVEGAPPFSNGHQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX32</accession>
    <name>A0A401GX32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0902030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617237.1">
        <property type="nucleotide sequence ID" value="XM_027761436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX32"/>
    <dbReference type="GeneID" id="38783241"/>
    <dbReference type="InParanoid" id="A0A401GX32"/>
    <dbReference type="OrthoDB" id="3265156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="83030" checksum="89CCB4C583F15A94" modified="2019-05-08" version="1">MSFSARLSDTHHDRRRISTVRTGTIIRGTPTPNAEDAQPNGRTDRRTDNPPAVRSAPRKSSVRDALSSRRQCPPLGAQDQSGSRPQRVSLPLPRTVSYPPLPRLNDASALRRQGSGGEQNANSYTTYVPILAPYRATEMASISEEAAGTQRRSTPIALPRFVANEAAMRRHGLDSLSPSTVPALAATTHDVSPVSRLRLDPLFHERRLELSAADLNSQTSENLSSPSTTLPFAKEVPVNIAADDAKSPTLNNPPSQDKDPNVSESIPSPGHAQALPDPNPSCDAGTMLLGDFCGPRKRPTLNLSTGSVTEALSNLTSTQTAVPVADSISHPDPALNLPHPPKGVMRSMGSTSTSNPDAEPTIDLIKHARSASEQPTTRGIKRERSASPPLRTSAAVVRPVMEGSLRFAPVPEECRRPHPEWQRNRRAWIERECAALQGKGLKILKTFTRDDGMVIDWQSCMPVMSDTLLPAHPDSRPLPSRVQEVFEVDAPPAKRPRTSRQERSARPASENGTDIIDVDLSESTTVPVTAAPAPAAKPGALPPQEKPAPRDYAFATGRARLASPVVVDLPVQVEFRDADAGPVRAGLDAPRQPATTDTELPAPSASPEKLVRMPSMEERAELESAALAFLERYIETFDQDRSALASAYSRTATFSVLSPVPDAPGGQHIKQGRMEIVEGLLSLDGRWRFCSGGEAAKVDYDAVCLGEVGVLLVCYTGPRACGKAAGGRWACDQRFVLRRREWDEEDRSTDNLWPLVAVSHQMTVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX64</accession>
    <name>A0A401GX64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_1000530</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617724.1">
        <property type="nucleotide sequence ID" value="XM_027761923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX64"/>
    <dbReference type="STRING" id="139825.A0A401GX64"/>
    <dbReference type="GeneID" id="38783728"/>
    <dbReference type="InParanoid" id="A0A401GX64"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="191"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE86811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="38898" checksum="9A680155A6F032E7" modified="2019-05-08" version="1">MKHKSEAFEKVKEYLTFIERHFGHLPKILCVDNGSEYINKDLKGWCCEKGIELQTTAPYSPSQNGVAERFNRMLLELARAMLIARKLPNFLWAEAVAYAAYLQNRALMKALHGKTPEEVWTGKKPNVAHLRGFGSDVWILTEGQNLSKLEPKSKKHTFVGFADGLKAVRYYDVGARLIRVSRNFVFADAPNPASNVPVHQLDDSDRLPLKGESGGAVKQQPPTSASKPASVPVKADQSNKKHDGNYIIEEDLPPEIQESMREQPTFLPAPPKIPLCRMTRATQDHDYRRMDNPHAQPAKSHELPGVPKENAPGESAKVAVTPEEFEEIVQALYATALALGDRTASAGDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXM1</accession>
    <name>A0A401GXM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0904130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617447.1">
        <property type="nucleotide sequence ID" value="XM_027761646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXM1"/>
    <dbReference type="FunCoup" id="A0A401GXM1">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXM1"/>
    <dbReference type="GeneID" id="38783451"/>
    <dbReference type="InParanoid" id="A0A401GXM1"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01738">
        <property type="entry name" value="RNABINDINGM8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="59"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="166" mass="18256" checksum="8D256D6BF1009716" modified="2019-05-08" version="1">MSDDEMNIDEGGTGVVRRKGRGFQSAGGNESAVTSEQTFDRVESSQVTETRAARSVEGWIVLVTNVHEEATEEDLMDKFGEYGEIKNLHLNLDRRTGYVKGYALVEYETMAEAQAAIDGASGTALLEQTLHCDYAFVRPPPSGPKKGRGREGRGRSASPSRRRDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXN3</accession>
    <name>A0A401GXN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1001970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617866.1">
        <property type="nucleotide sequence ID" value="XM_027762065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXN3"/>
    <dbReference type="STRING" id="139825.A0A401GXN3"/>
    <dbReference type="GeneID" id="38783870"/>
    <dbReference type="InParanoid" id="A0A401GXN3"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="64"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="287" mass="32044" checksum="213E4FE31B708914" modified="2019-05-08" version="1">MSRSSKSKADKQMDEKIVQFCAVTGASTRDAKRFLEKHKRLDIAIDSYYTDPSGGSTAQAVPPASTSKLNQLFDKYKDPDSDNIAVNGTINFCEDLGVDPEDVVLLAVAHDLKSPAMGEWSRKGWVDGWKALGCDSISAMKAALTRMRDSLGSDPEYFQQVYNYTFEFSRPPGQRSLAGDMAQGFWELLIPHGLAGGALAHVGSRDGDEDDDMNGDEGWNDEHTQWWFDFLTERGSKGVSKDTWQMFLEFVRTIDSKFEVYDVEAAWPSTLDDFVEYARGRIAKDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY51</accession>
    <name>A0A401GY51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1004020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618068.1">
        <property type="nucleotide sequence ID" value="XM_027762267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY51"/>
    <dbReference type="GeneID" id="38784072"/>
    <dbReference type="InParanoid" id="A0A401GY51"/>
    <dbReference type="OrthoDB" id="3268823at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="519" mass="53609" checksum="D83B1DA3B1B631D6" modified="2019-05-08" version="1">MSADLPPLLPTETGTPPDEWARSTTTAAFSRPEPAPAVSRGRSSESTPGVEFPGAFPKSQQTHSENKPTTAGPAASDPASKAQAEHGAGIDFGDAASRAVQTVTSTAASTAQYIASYMPSGATQGSPVRASEHDVIHSTSLPSSETMGAGEHEHVGGAGSLPGSVSEESVSRLPDERQMEQDPKAGVADTQPKPEDVNIAGTYPFAPYGPAVGESTGAPAPMMTHETHQHVDVGGTYPSAPYPHATSETTGSAAQKAKGPQPYEQQSGVGIFPGAMSERVHATPPGGAQSMPSQEKGGIKPGEHVSEAGELPGRQGESGVAALPEKRAEEQRGQSESTTGKVTENTKETARKAVPSAGHKEGKVSDARADEEQADMLHPTLTPRTHALGSPYAHWHGVCVGESYKRGVGVDIEWMEAEGYDTDYHPAELHPDTRGPAAGGAGAAAGGVKGESAVPESTEAPKQDTSALPQVQACHAEKAKKVGFMEKMRGEAKILLGKVEGKKGEAKVEEGKRVKAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY96</accession>
    <name>A0A401GY96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1000160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617687.1">
        <property type="nucleotide sequence ID" value="XM_027761886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY96"/>
    <dbReference type="GeneID" id="38783691"/>
    <dbReference type="InParanoid" id="A0A401GY96"/>
    <dbReference type="OrthoDB" id="2588098at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39028" checksum="191F3A6262116B06" modified="2019-05-08" version="1">MTQCCRIINIDKQQFLGDNFYGPLGRWLFSNSVDRPLTELFAIPFDTPITRVLEDFPIVERMRVNALGKLDKFPNEVLAMIFDCFDSVPDAICLGLVNGYFLALGRKRIHALIIARSAPWSGDRIICLGKRSREDHFPAGMLSEHEKHMLGMLKLQDDSPAACAADSDDDSNSDWPGLYDYAMEHFEEIFPNTNTQKTKDMSLLMRNLPAPYSAQSMSEPDYVDGAQPSTVWALCNLSKREYVRGDKTAQLTHSATKGPCTDGSVGLGHVLVTRICWSSDSRVGLQYNGDLHQGPWAGDRIVITTLDRMPIGHWTDISKEALKLVEAVWDAEFANFKHPDWRKLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYR7</accession>
    <name>A0A401GYR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1005530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618218.1">
        <property type="nucleotide sequence ID" value="XM_027762417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYR7"/>
    <dbReference type="STRING" id="139825.A0A401GYR7"/>
    <dbReference type="GeneID" id="38784222"/>
    <dbReference type="InParanoid" id="A0A401GYR7"/>
    <dbReference type="OrthoDB" id="3270336at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="321" mass="36819" checksum="B5CD48080C83139A" modified="2019-05-08" version="1">MVKNDIQVKEELVEQILGTLDEGNVKHDWLEGLLYARYGFINNPRYEEVTKKVLEPKHVMGALAEKQYRFEVEEMGHGIIHFVSSLANAQVPEEQWDLCEKNPAYVLEIHKPMFRVQRYKFADNSWGYALTPVKTRLIRSWQIVVRDAMAVIQCVRCEWGPSLEELAAEYVRIGIPFQTLMSVAMDRVQWRDTGLCPSVPRRSKDFKATQEEYDIYVHRRDQLLSQPRARAAALAGGILWRLSREALEHRRDVPLGPSKEVTSYYGPTAGEQSGTLDDTLTEDEIKILHGMYYVETGESAVTLCQTSYYLISIQVMVAGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYS2</accession>
    <name>A0A401GYS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1005610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618226.1">
        <property type="nucleotide sequence ID" value="XM_027762425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYS2"/>
    <dbReference type="STRING" id="139825.A0A401GYS2"/>
    <dbReference type="GeneID" id="38784230"/>
    <dbReference type="InParanoid" id="A0A401GYS2"/>
    <dbReference type="OrthoDB" id="2560085at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="177" mass="18939" checksum="20331F424B9466D6" modified="2019-05-08" version="1">MCRTGFPADFSRLALPAHARSSSAVVPPHLVPPSLPPLSPSLRAARPAFSCTSYLLLSVWLFAALVPFTDFVANRQANVSATLDGIALPQSVIQAVQAQSGVTGTYHEISYLRLATVFPRWIAFLFGALSAVLSYTTATERSPDSARYPLVAGGRAGSIRDVDDKPKEAEQVGIRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZD6</accession>
    <name>A0A401GZD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1101870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618423.1">
        <property type="nucleotide sequence ID" value="XM_027762622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZD6"/>
    <dbReference type="GeneID" id="38784427"/>
    <dbReference type="InParanoid" id="A0A401GZD6"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="312"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="883"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="683"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="733"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="914" mass="97807" checksum="BB0B25A894457A42" modified="2019-05-08" version="1">MQPSNSNNTQQPQLPHQHSPKRSSPLSTAQPLTCDTTTARTPPPAPATPPLAHTAPPNPLTPPDSSSRSSASADPPAESPLPSLALPAAVTSTLSVSAPQFHSRLDAPIDIHQLAPRLALAAEGAAVDTVAPPAAAAAAAAVSVAASPAAPDLGHCSPAAAGPDAQAPQKTHPSAAAPEFVPSAAAPRPPQELRTPNVYINGLPPSFPEDQLYAMTREFGTVLSVRTFTRHVSDKPSGYGFVLFDGVDAAERCIETLKKYRNLHPSFSKQIHKIPGTPYASLGDAAGEGAPATRPTDSFKARMEQLQDMTSTNLYMEGLPLSIDEPTLSALVRPYRIMSSRFFQTRLSSPPRIIAFVRLETRVAAEEIIERLHGRMVRGWQDTGCRISVRFADTSEQRELRRMERCTHEDEQSPARLTMAQAALLNLKGTQLHPDSPASPSFGSFPDVNTGVGLASDGYTLGQTAGSVPPLSRVSEALQFQQRQQLLRQSIDDLQDPAMALDAYGDFSANGAFIGQGLRNGQNISDEDLLRLDTEAELQAVMGAGMLDMSGMVNRADDGYTPMERLILQAHAQRQQTQLLNAQRERLAAQVQPRGLSDLRSSSNAANKGGSGAPGFATALEVHRRLLDVLPSMSEDDFHASAAGARQAFAHLTRGRDVSASQSGLDRVAIEQSAGLARDFDQLSLSQQQQQHQRYQTHASQARAEAEAQAQALHTRSTTLPSRYLSNRDGFPSTLSRSVYSNNSSMISNSNESNMNMNRHANSSNNIIGHLSKQSQYTSTNALRNNNNDSISISNIAPRDGGRIIGQNVNNLFSSKNNVNIRNTRVGGTHTNKLGAIPLRHSSHEADDEDGGSPLLLSPALTYSARTPASMSPATPFSGFFPNNGETFEGPAMGEIGGGNSKGEVLLDEKIARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZJ9</accession>
    <name>A0A401GZJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1102830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618519.1">
        <property type="nucleotide sequence ID" value="XM_027762718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZJ9"/>
    <dbReference type="GeneID" id="38784523"/>
    <dbReference type="InParanoid" id="A0A401GZJ9"/>
    <dbReference type="OrthoDB" id="2803682at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44408" checksum="12214234FB031774" modified="2019-05-08" version="1">MDDSTAEVEIITVIAQLARPRAKEEEGSEGDARVRELEWEWVQCLKIQKACILEFSPKPYKWIRPLIDGNFSVYFHVTPAELSRMFPLDPYIAEPYCATGSTTEACCDGFRDEVEGRDVRCVASDSLARSCDATHLIGQSKGDIGIKVLTNARSRDEDKNDCIDDIDDIRNGLFVTNFLHRALASRGVAFLVTPNFAMSTNDVDPTLQPDEQRWTIHSFEAVFNPDLRHNRVHNLLVPHGQALHLPVDRTSWPPGILFDAVYAAAVMKYFSHEDFSAYLSQHWQGRFYLDGDMAQIEHEREQNAMKKAQQKRERAERREKGDIEGGGKMDIYDMLLLLPQIVRRPPTAEQRERHLAEQRESELAKPMMCSSCFVGAVLLVFPNILPSSTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZP9</accession>
    <name>A0A401GZP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1103180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618554.1">
        <property type="nucleotide sequence ID" value="XM_027762753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZP9"/>
    <dbReference type="STRING" id="139825.A0A401GZP9"/>
    <dbReference type="GeneID" id="38784558"/>
    <dbReference type="InParanoid" id="A0A401GZP9"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10562" checksum="CF3739BCB0C488EC" modified="2019-05-08" version="1">MHSVAGISPPAIFVPFSLGGLSEADLNVSAAALTTLQWRPRRIYMSTLLVDLDTPDFSMPYVIIVSYTLIALIFGSVFNLLTRKCMVVSLNNEGGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZT8</accession>
    <name>A0A401GZT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1103580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618594.1">
        <property type="nucleotide sequence ID" value="XM_027762793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZT8"/>
    <dbReference type="STRING" id="139825.A0A401GZT8"/>
    <dbReference type="GeneID" id="38784598"/>
    <dbReference type="InParanoid" id="A0A401GZT8"/>
    <dbReference type="OrthoDB" id="3364608at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="426" mass="46621" checksum="7A49C8CA32F9CDDE" modified="2019-05-08" version="1">MPTTRSRALLDSSAVDIPPVRRPPPKRSASHASLPTPPRTATKRKRARSRATDSDVDEDEHVPAIGEDEHSDDPERERASRRDGDGALIIGHKKRKTLDAIAEELSEAVVEEAFWLDDRNANAGKSQLEPKSLPRTRARSRTRSPSSSPPPAAHLLRRGHTGLISPPPSRRQRTRVGRRPVTPRPRASTSGKPSLFPKRDSPDNPFLADTPDDSPTTPVRETDAGAMPHTPVKQVEKPTLTWVFRGKKVELANPHFHGTAEDDEDDEETAKHCLLPEGHPDYSPPPTYAPKLLFPEAHKHTRRRAPKAPVPTTEKASIPMEAKATSKMKAKAEPAEVSPSDADPSDDEHDDEAVEELVASTVTEAAVQAAMEERLAKRIDAATAAATRTRTRSQAAPRLPEVKDSDIPRRAMGPARAPKPVKSVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H007</accession>
    <name>A0A401H007_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1104250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618661.1">
        <property type="nucleotide sequence ID" value="XM_027762860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H007"/>
    <dbReference type="GeneID" id="38784665"/>
    <dbReference type="InParanoid" id="A0A401H007"/>
    <dbReference type="OrthoDB" id="2785713at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8947" checksum="B0CE07B3DB42D835" modified="2019-05-08" version="1">MTEPQCDLARLLGLAQQVAATLPTLGYVGFDSSLGWRDERRVPRWFCVVSRDGDIPQLELLSREQGEELELRLSSLDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H040</accession>
    <name>A0A401H040_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">mRNA export factor mex67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1200110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618700.1">
        <property type="nucleotide sequence ID" value="XM_027762899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H040"/>
    <dbReference type="FunCoup" id="A0A401H040">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H040"/>
    <dbReference type="GeneID" id="38784704"/>
    <dbReference type="InParanoid" id="A0A401H040"/>
    <dbReference type="OrthoDB" id="25872at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="9">
        <location>
            <begin position="319"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="10">
        <location>
            <begin position="536"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="587" mass="64724" checksum="9ABD198AC21AE6C7" modified="2019-05-08" version="1">MFSSPTQTQGSSAIAANALRSAGLMDRDARMRDVSDKPGGRKGVTKSSHANRTPHRPRAIDAVIGKDQASTSMNARAAMLAARIAAGDSIAIRGAAKGTLGRLRRNAMSTPDGKGSKTIELWEEFVKLRWNAEAKFLNLERIGEDELIRYHRLWSANSTTTSYKVTAVVFKLAARLFPDVETISLAYNELKTGYAISSLSHYLPKLANLSLQGNELTSWKDLDYISGRKGKLENLRELILLGNPVRELEYQNNRGDRYRSEVARRFPSLEVLDQEAVTKIAFDVPHASTSAAASVPHITATTFPCEMVPSFITGVDSALVSNFLMRYFPLFDRQRAGLLDVYHPEATFSFSANTGIPPRARIEGLHHSMPNQRKLEWPGWLIGGRGGSRNLSRIWGSVDKMTKTLHVGNEEIIKTIADLPTTKHDLVGAPDKFCIDAWPVPHGDSIHLFVSLHGQFVEEPAAGVRSFDRSFILAPAPEGSRAKQNGWDVVILSDQLNVRAYSSPEAWRPGPMRVQAGDPLPGLIPEAQAQLQQIPEPQRSLVTQICQQTGLNVRFAVDCLEGNGWDIPRAVANFEQVKGTLTRDAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Q1</accession>
    <name>A0A401H0Q1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1201960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618883.1">
        <property type="nucleotide sequence ID" value="XM_027763082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Q1"/>
    <dbReference type="GeneID" id="38784887"/>
    <dbReference type="InParanoid" id="A0A401H0Q1"/>
    <dbReference type="OrthoDB" id="3269821at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="81125" checksum="286EA9EFAFD85544" modified="2019-05-08" version="1">MVLEIISAMASEVYLTPNDTVAVSDAVPHLSMPLPPKRVEQPPPSSPEKRLPVPPQINTQRGIQLSSDMLQFPSQADTRSRPSTVPLGARKALGRILRDPRTLFHLLYVLSWRDFHALSSACRDFRQQLSHNSAHRDVILCHFVPGYREALQIGDLQHYREVEVDFHDLTMLVMSQYVPLHKYPMHSLSILNALQQPAGSSQLFALTQKYVALTKAHSRFVLLLQSLVHSPSSAPTPSSDDESDDALGFLASSQPRTDFTQFPGVRELVFPAPLSYFGPDQNSDVPAMDGFRHDGERGHRRHTAGSSVSTMRAVSSSPTRPTAERHLTYGHLSHEKHKSHSLVPILTGHRRLPPPPPLADPPALKYYSDSWRRSRMTSQTAQQRLSVVSDDQWRAELKHPVRRFETVNISRESSLSNSSPSSSSKCNTESNTESTDSRPSVQDSREPQPSSFPMSAFAVPRGTSPHDLFLATSRTRAPVLRTFVPCTELDEHAIAACEEQLLDAGLWEHLSVGDIVCNFGYVPPPEIDDATHPGENRQKWLLFDGYNLVQYTSPSPPPLENPLTLPSPFYYAHILPPFSNPVHNLSLPALPRSIGKLGYNDPHMQLTLAHLPTRVRSPKSPSGFAIVSKYVWLARLPCVGPNIGIQSGLILGTAWQGEWMLEGEGTREGKQSLLDALTNDPSGSGMTRRAQWEIVRDKSGGGRLWMRLLMSNVDDIPSGLEVSPSELVTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0S3</accession>
    <name>A0A401H0S3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 1 regulatory subunit SDS22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1202550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618940.1">
        <property type="nucleotide sequence ID" value="XM_027763139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0S3"/>
    <dbReference type="FunCoup" id="A0A401H0S3">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0S3"/>
    <dbReference type="GeneID" id="38784944"/>
    <dbReference type="InParanoid" id="A0A401H0S3"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="U2A'/phosphoprotein 32 family A C-terminal" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="368" mass="40972" checksum="3477A46EEC513CCC" modified="2019-05-08" version="1">MPGSQSTSNPPSSAAPSAAANAPEPAIVPKEKSARIAVAPSHPADGDTSGEEDGAEEEAAVEDAEILEDLPDDTQEIELVHSRLSSISKLGLQRFGPYLKKLCLRQNYISVLDPEILKTLVVLEELDLYDNKVKHVGEGLDELSNLLVLDLSFNLLRHVPDTLSKLSSLKTVYFVQNKIAHITNLEGVGRTLRSLELGGNRIRTIENLDALEILEELWLGKNKISKLENLGRLKRLKILSIQSNRITKLEDLENLENLEELYLSHNGIERLEGLEHNLKLRTLDIGNNFVPALENISHLINLEELWINDNKITSLTDLEPQLKHVATLETIYLEGNPCQKSEGSSYRRKVVLALPQVKQLDATFVKQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1D5</accession>
    <name>A0A401H1D5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1300560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619154.1">
        <property type="nucleotide sequence ID" value="XM_027763353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1D5"/>
    <dbReference type="STRING" id="139825.A0A401H1D5"/>
    <dbReference type="GeneID" id="38785158"/>
    <dbReference type="InParanoid" id="A0A401H1D5"/>
    <dbReference type="OrthoDB" id="2753421at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="559" mass="64329" checksum="A4159DD3E2DCA805" modified="2019-05-08" version="1">MPTPRPSPRRPSGPAGPSIRPSDCRVTVKIDENAKTDYPTVFKTIDVKVRYPRGKEVASLRAVQIDRRIACEGRFHQVMDSDMEDRDELEMMGRVLFTKYGEVRPWIVEDEQLKGTGCWGNELSDGMLIYILSVRVPDEASRGRGLGSLALRSLLRSEHVQKDDIILAWPTLHDQSQHDEETKNLSSFYHKNDFRRVGVEEKEEYARKYPLHNKIFCATKEDIEQIIRATFLQNPLSIRRQDDEGFTPIHRAAEAHNLIATNILLELGVQEDLVKRDNARLRTPLMLCTDQLRLTRELQETRHRRWLGYSYSGLRVEAMLKRAMGQYAGTDDEYVQKNSWGCTCGQCVGGWLSPKIRYALEACAECLYDSLLEMQKCIFVDGQPITEQSILTNEGLPYIPPRLRSRIDVVFYFGFRVIFGAIGQVIQEIEDASNPTAEQIQERILRKVHGDLPWTNSFELQPVEMDAVMYYLSKGGRISYALDCVIAGVPSEFEMDDMYEGVHEFFGIKETEREGRDPELDELERKRKALPACANDREFLLVRHRMGLERMGPYGDHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1L5</accession>
    <name>A0A401H1L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1301130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619211.1">
        <property type="nucleotide sequence ID" value="XM_027763410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1L5"/>
    <dbReference type="FunCoup" id="A0A401H1L5">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1L5"/>
    <dbReference type="GeneID" id="38785215"/>
    <dbReference type="InParanoid" id="A0A401H1L5"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="495" mass="54326" checksum="38C790965EF4D38E" modified="2019-05-08" version="1">MGVFFSVPLAGVFGTVASSCLAGLAFCFTSTAASMFCKSCNCNSSIATRVGFAIIFCLNSMLAWLMKTRWAIDLIQKWSHGYLEMECAEGRCYGVLAVHRICFALALFHAILGAGLIGVKDTKDKRASIQNGWWGPKVLLWLVLLVASFFIPNGFFMFWGNYVALIGATIFILLGLVLLVDFAHSWSETCLENWEASNSNLWQWILIGSTASMYAAAITLTGILYAFFAQSGCTLNRFFISFNLALCVVITVMCIHPTVQEYNPRSGLAQSSMVAVYCTYLIMSAVGNHEHEACNPLRRNGPGTVEGARTTTVVLGAVFTFLAVAYSTTRAATQSRALVGKNKKGALQLPSDDDGHAELGVVSSQPSRTESPRYQALLAAVEAGAIPASALDEDEDEDDDEVNPETRDDERTGTRYNYSWFHVIFAIGAMYVAMLLTDWNVVKASTGQDDPDQDVYIGRSEVAMWMRVVSSWVCMLLYMWSLLAPVLMPDRFGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1P3</accession>
    <name>A0A401H1P3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1301270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619225.1">
        <property type="nucleotide sequence ID" value="XM_027763424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1P3"/>
    <dbReference type="GeneID" id="38785229"/>
    <dbReference type="InParanoid" id="A0A401H1P3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="289" mass="32944" checksum="22D66908BE88AABD" modified="2019-05-08" version="1">MTEYINPPTYPQSVADNRGPTSRTYCGCTCHTNQPETWLFPYKYVTVRMYDYGPLPGSGFSQAIMQLDGEGSLDLVKCAEIWSVAKVTPRRKLELLHDGILPADLIESCAEVSHGVPAIALAEYAPLSRYDIRSNIFHTPQMVRVRWYADAEWTTTYEEFFAPLDSTCGLSIAQIARNRGVPLGKACVFDATEYKKRYCTFRTRYLYAGELPAVMDHRGFLALTSVEVGVDLDVKLPRSGRHYWFNIFNAWMSMPPEQRMDWSHPIASIFMVPYLAQENRICRHTVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2L9</accession>
    <name>A0A401H2L9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1400760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619584.1">
        <property type="nucleotide sequence ID" value="XM_027763783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2L9"/>
    <dbReference type="STRING" id="139825.A0A401H2L9"/>
    <dbReference type="GeneID" id="38785588"/>
    <dbReference type="InParanoid" id="A0A401H2L9"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="207" mass="22675" checksum="2B4C40ACB60968BC" modified="2019-05-08" version="1">MASPTPFILHTENLTPKSFKVELLNITYVGRDGKEHPWTTASRKPCGASGIDAILIPNIIRRPNHPPAMALVIQYRPPTEADCVEWPAGLIEVGETPQDAAIREFKEEVGYDGGRVVHTTPTAVADPGMSTANLQFATVEADVKEGDQPPVQNLQDNEDIVVKHVALDDLYDELVKYAEKGLAIDARVLTFAMGWNKHKEYSSAGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2N2</accession>
    <name>A0A401H2N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1400730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619581.1">
        <property type="nucleotide sequence ID" value="XM_027763780.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38785585"/>
    <dbReference type="InParanoid" id="A0A401H2N2"/>
    <dbReference type="OrthoDB" id="3192989at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="7">
        <location>
            <begin position="255"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="8">
        <location>
            <begin position="752"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1666" mass="186950" checksum="14D5B41FCEBDBD01" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSSASASQPPEPAIHLIKMSNLSPMPLTDQIAGVLELMFRRKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNPVRLQWDIDRYCDSLSIQPTGQNEVLEAELEWKWPPPFGESEIRIDQPATLVDMHGRILAWILPRVLIPDRQTKMLQATRALHPAIAASKPSSTTASWRHNPLYFLPPEECAQFPAGSLCLSPGWFQQVREHMESGRLETSASLKLEGGRSWLRDIHDSSALLGAILAVVHPTLYAAGRQCLGLIQQDPELREMALNWSSPFNALQVIANRETPFHRDSKTRYTFYDLLATLGNYTCAWLKFPAMRVAIDYSPGTVIAFCGKAIRHGITRADGKRLVYAYFMREGVQNRLGIPAPHWMQASYYASHIGMCTVHHRRDIMPKTDEDENTMQGMETVDGSFIGGIKLAEVMAKSQGVVITDGSIWLADLEVGGDGGEMCSVEKLRNKSRLVVDLDDEVEFVTKVAKQTTRGVRYVDVPLPMPTGSNVPSPSKSPWKAPASGPLFNLDDGDVLGNIGVPIQLDPAAQKTKTQNDFMRDWIPHRDDYLHAIVEMEAPPEPRNCAECKVGEGRWRCLDCMGRPLTCTDCCRNGHQRAPFHRIEHWQGQYFEPASLYRVGVCIHLGHGGDPCPLGAFTAHNNPAPVVAPGSDFWNASNEDLNAHDGEISDDGEVPFNFAPLAGTLDGEARQTDDAPDPTWEEDVPPVLSRPPRRDSYGNRIIVIVDISGVHHIGVDWCQCEMAVECDMQLLQMGLYPGTVKDPHTAFTFAVLDDFLLENKECKTAALNYYSKLKRVTSNAFPGTVPDRYRELMRVSRQWRQLKYRKWHGFSHDALRPVEKGGLAIFCPACPQPGLNLPFDWQADPVQWKFKCGFVMDGNFSAEHMKMKHPEEDVALSDGQAFMVGQEDYKAHLAVAMESHQRSTCHEHRAVNQANVDRANLDATGIGATACARHGFFVPHTVVDFQKGERQMNMDYSLSNALLTLTGITLVLVMYDIMCQYGVHVRKRFRHSAYLRMPFELKIDQGIGLFHVHGHQDCCFQRFSPNFIVGAGMVDGEVIETLWAPTNEVSGSTRGMTRAHHQEVLDDHMNDSNWKKTTRMVPTLMTKWKCVLLGFPRSKESFEALSASTDEEVLEAWQKEYDDAMEARQNDPKIMDTFDVQLRKAPGKDLTQLRLVGEESAKGLEKGTAGWLSTGLKIQEAQLKLANDIRKAGQNPSVAEDLKTLERRQRLEVSILTFQRRSEKFMGRLEDVPAMEDRDDGALWDSLDENPFQIHPEDAEYGEDAIPPEQASLNLPSQIGFVAAIANGLQTLAAQELELRKGLMNDILHELRMALGLKSYLYRKRVRPANSVGTMTRAQAEVHAADQTVLACARLYSANRRAIMRLGATDEDLALYRPLDKKDLHVKTAVIEASTSGLRNVNLAWFWTMDSSTSDARPCLFSRGRLQLEVYTWRIQEAVLALEPDPDHFTKVRWEEGLRREMFAIRGICGDLALAGHADHIDHGGVIASVLTVCTFNREVLRPISIDVKAIPRPTTLVPRPKNLLEDSPDYWWKWDRQVGPAGSPMEAWWYKLGDPWEKVYTVSESTLVQLEQLHFRVANLTSWLHKRTDQNLDVVLEELQEATRQLRELGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3F6</accession>
    <name>A0A401H3F6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1403520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619857.1">
        <property type="nucleotide sequence ID" value="XM_027764056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3F6"/>
    <dbReference type="STRING" id="139825.A0A401H3F6"/>
    <dbReference type="GeneID" id="38785861"/>
    <dbReference type="InParanoid" id="A0A401H3F6"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="562"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1278" mass="143353" checksum="21146DC77765B39D" modified="2019-05-08" version="1">MALSNLFRIRGLKSFMGRERRKSALPAPLPLAASADTFPSSALPSSEIAAAHSTSPVSAALSDSTVPTILPWTPLDSPPQSMPEAVVFLSPGTSSPILQERGSGAHANRLHLNTTSDSSMSDVSVSTTDDDRVIGTLTVVSAQINKHGSSSKAEQALNALDDKVTTIQGQETLATTLYAPIKSAVALEAVSGIKKSIEDGINSFLDGMPVLMKALDEVAEIHPFVQVAVLAFKAVYTLETKRRANDKKIIALYVEMKDMIAVLIQLKTVKDEEDVGPDGVTLKGRLQGLVKNTADDMKDCANTCDAYSKMKLLAKVLKGPLWEGTLTNFGIIFTKRRTEFEFALSIHIGRGVDKANRKLDNLAQELKERADVLLQFMQSYVPLEQRELVALVQKKGGTKAVLDNENVLKELNSYESRRPTKTGDTQNQASLGHARTSKDDFEELKSDLRHDPAAAAINNFQTFEPKFAIQQRQLIEEVDRVVTRESDRVIQSVTSGTHDKVVDRDLYNVWKEMAWRGTVKARHFVLALRHYYHEKTDGGIRKESATKSVLTPDPDAWALEYLSVKRLHSIIDAFDEDASGFITVAEVNKLTAIRPLDWSLLHWIAYWAVGWRINATLYIRRINELLGKMFAIKEEVYATNGPYVDEYLHTVWAGVTSLTCSMRPMTSSDNLQARFKSRMDAEEERIRTNLEAVRYNINDMETLSLITGPGTIEKVRASSSTGAPDADVHDFEVVRLCRTKVVDRNELRDCADSLKWVFDTVQARYDELKDSKSSTSINNLRLSRKRSSNPQTSEFPTYLYKDEEEAQDIRHEDILNYPLDENYLYDCSAYEISDSEVETEGDRKAEAHLKALVGTWYVVVAQGDEYPSQSMFIFHVHVSADGRSIEGSGKTPEGTAYARYTTRVSTKCFRGHLDEEGTMLQGVWGYDSTDGSNDDFVMSRLAPEVLIYRPSPRQFAENRIEALWKFALSEVEARVRRQICSWSHFRQRRDIRKRYIQLLTRKWDFGRPLGGDEEDELTRCRKNLTPADARFYLTLYHCQLRTTPAHFGAACDNCGGVIGGTRTICIDCRTDRADRTVDICQDERCLSAEVKRSDLASPHLPSHAVYKVRRTVHDREFGPLDKEARVALQNARATFKHAVEVEKEQTEGAAKDDDRTAKLVNDTLKCIVCEKRVVRPCWLCMTCRDVYICLNCDPTDGITIGGHDKRHPLVRCPEEVAAEEPSTIERRIEALESKLDAVDGKIAEVDERLLRIQQLLQMMTMGAPTPSTAMSVSAEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3G8</accession>
    <name>A0A401H3G8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1403610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619866.1">
        <property type="nucleotide sequence ID" value="XM_027764065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3G8"/>
    <dbReference type="GeneID" id="38785870"/>
    <dbReference type="InParanoid" id="A0A401H3G8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019082311" evidence="2">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="138" mass="14633" checksum="474F06D4A5479287" modified="2019-05-08" version="1">MRSSAVLAIAAYVAIPGFVVATPMPADGSPPIIPDGAPFSRKDALNVSHSSIESNSNNQPHSRDDDGFPARVVDDIIIRAEPIVDAALDDIHGIVYLRQFFDSKSPRPSANSGGNSGSSQPQATTTEVRMPHYYGDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3J5</accession>
    <name>A0A401H3J5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1403670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619872.1">
        <property type="nucleotide sequence ID" value="XM_027764071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3J5"/>
    <dbReference type="STRING" id="139825.A0A401H3J5"/>
    <dbReference type="GeneID" id="38785876"/>
    <dbReference type="InParanoid" id="A0A401H3J5"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF440">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="259"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="411" mass="46924" checksum="58CBB28A6755AE12" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGKDAKWPPKPTVEDAPDEEVSIFKEGGLPELITTETSPTSFGHSESIREIVADNTERGELPAVRNDTEPDDPLSEPPMDQLDDDDLVISYIAGEPVIGVFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALHPCQDYQYLNEGTVKNAYPLPLISDLMDQFRGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVRTRRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H411</accession>
    <name>A0A401H411_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1501760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620081.1">
        <property type="nucleotide sequence ID" value="XM_027764280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H411"/>
    <dbReference type="FunCoup" id="A0A401H411">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H411"/>
    <dbReference type="GeneID" id="38786085"/>
    <dbReference type="InParanoid" id="A0A401H411"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="554"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="654" mass="72876" checksum="564899248D905810" modified="2019-05-08" version="1">MSGTRGQIEKAIGQIQYKGPVPEIDFTQHQLDNGFMISTQERVVKEVQAPAMSIPTDAQFFSREDPTKPDIAFLKNHFYREGRVSEEHALYVLEKGTELLRAEPNLLYVDAPVTVCGDIHGQYYDLMKLFEIGGSPANTRYLFLGDYVDRGYFSIECVLYLWSLKMWYPDTLFLLRGNHECRHLTDYFTFKLECKRKYSDRIYDATMQSFCALPLAAIMNKQFFCIHGGLSPELQTLDDIRSIDRFREPPTQGLMCDILWSDPVEDFGQEKIPDSFVHNHVRGCSYFFTYQAACQFLERNKLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTLFSAPNYLDVYNNKAAILKYESNVLNIRQFNATPHPYWLPNFMDAFTWSLPFVGEKITDMLLAMLNCCTKEELEESSDEETISPAAHTDESLERRKVIKNKILAVGRIARVFALLREESERVSELKSVSGSARLPYGTLALGAEGIKDAISGFEDARKSDIENERLPPELFDADSQEGKAILSSGPSTPAEGAESPPSANGVAAALEQAIVRGAVTPSINTAAAASSPSSPTSPTSSIPVTPFRRGHGRQASLGTTMTSPSTRRRSLESTMSLIKEAVDVKSVQDQELVKLAEQVAGPSTRNGNGATDSGRSSPMVPPSRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4D6</accession>
    <name>A0A401H4D6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1502820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620187.1">
        <property type="nucleotide sequence ID" value="XM_027764386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4D6"/>
    <dbReference type="GeneID" id="38786191"/>
    <dbReference type="InParanoid" id="A0A401H4D6"/>
    <dbReference type="OrthoDB" id="5346979at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="280" mass="30369" checksum="F0B8E6155740033F" modified="2019-05-08" version="1">MLKCYVMSSNQSGDVSQSQRHPNEDASPGYRSIFAVDGSNSSVPRWLPLSLLALTTAALAVPAVMLWCQRGVALSRTLTDPPPPPPRRTVSAGTILSRRTASGGAPPPRRTVALPPIVPQRAFPSSSQSSTMQAGGPTLIPDAEDNFNGALYTMKAFGIATLLVTVGAGTAVWGIKTALGVRDTQEFADRVRMFIVKRMPVLSYRIYRPLGLEDEELDAKSVSTLSQPHPDDVLQWSWPDAEKRLKAAFERDGFMGWAEAAVTELEAEGQVERVRRGHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4J6</accession>
    <name>A0A401H4J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620234.1">
        <property type="nucleotide sequence ID" value="XM_027764433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4J6"/>
    <dbReference type="GeneID" id="38786238"/>
    <dbReference type="InParanoid" id="A0A401H4J6"/>
    <dbReference type="OrthoDB" id="3270165at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12372" checksum="139325BDFD8A528F" modified="2019-05-08" version="1">MHLLKSLTALVGKSICWPNLKTNIIPLTHAAFLQALNDALAMDGWPEDDHAIPFIPPDTSKLGHLNKQPDWISTASKRPREVYENSVLQSVNLLENSHVLKKLKSSHGSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5U1</accession>
    <name>A0A401H5U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1700540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620643.1">
        <property type="nucleotide sequence ID" value="XM_027764842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5U1"/>
    <dbReference type="GeneID" id="38786647"/>
    <dbReference type="InParanoid" id="A0A401H5U1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="130" mass="14523" checksum="DF0D95B3E4E7D51D" modified="2019-05-08" version="1">MTHSREPSPDEFGCMELHSAAVHAEIWSPGAVICFGMTLALDRAETSEEMASWAPAEIPQEVALEEARQVLAEYYEARRLRMQEDPLVGDLRYTVLIVVAILTCEVSCFKFVDVLRLSHAGIMKAHTCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5X1</accession>
    <name>A0A401H5X1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1701600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620748.1">
        <property type="nucleotide sequence ID" value="XM_027764947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5X1"/>
    <dbReference type="STRING" id="139825.A0A401H5X1"/>
    <dbReference type="GeneID" id="38786752"/>
    <dbReference type="InParanoid" id="A0A401H5X1"/>
    <dbReference type="OrthoDB" id="2931494at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE89835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="540" mass="62339" checksum="055B3119D3413947" modified="2019-05-08" version="1">MDPNQSHRDVQIVPRACLDYLHGAHLQVLPSSLLPDIQCVRREIKRLHDMGPDSIRHPLEWNTALPNLLKWSYYVHVPDVPPDMVEDVISTLKILVPVFQKCSTREIKAMGFLPSDQPVEVAHYLLLYNSRQKLCQYLLLPEIDRPSEALPYLEWLVENDTYFHRGSGNVPWLENPSLYSMYANALVLSGVFTAKTKVALEHVLEAADQSRFTRIMDFTPNILSARLGLSLVLTELGDPEAQKHTEWGVKFLRRNASLLPERDLRYTLIRANQPPHPVLVALGGEKWFVEDMRNPRKAENWMQKTCKHCGVHDLQKTLFHCAGCTTSYYCSKECQRADWKSHKMTCRDLQKTKARIEQMRKTDPRTAERLTDWLKWRNLVPTYVLHALIHAFNLKRDITRGRRHIFVQLVEHMPRVKDLRYRFRVVQCGLFTIKDMTSSLDGLFAQLAKKAGAEPLTMQGLVKDVDAMLERIPGGDAVPMITLKYGIGCGTSLNRLTTSQDLIRDLPYDPNWRRLINQDENDPPQPLIFSSRKRDAEFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6Q7</accession>
    <name>A0A401H6Q7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1801280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621017.1">
        <property type="nucleotide sequence ID" value="XM_027765216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6Q7"/>
    <dbReference type="STRING" id="139825.A0A401H6Q7"/>
    <dbReference type="GeneID" id="38787021"/>
    <dbReference type="InParanoid" id="A0A401H6Q7"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="932"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE90104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1197" mass="131198" checksum="337A89AB36DD164A" modified="2019-05-08" version="1">MASTSSAAVTTPTHLHPLSFDEPSRGRRPRAKNSVEETRPATSYFDLKAQLENSAEKQTKNTNASWDGSVRGYGKGGKRKSIKPAPLIVVESTSGTILSPTTMQYDGLHGLFAETNGDAGPIPELQVLHTKWHEYSDEAIKSTVSGYSAVASPSYVANHPYHSVIRILSSAVHRLSRARQELEESRQMLLEKDAARRERAQALIRELQPSEKDVGKRLLQSLFPDDDEEDHRVQRKHSEVSLSESLTEAIEDEAPLARSVSEDHITPAVPSVASEEEVSISNLGPSAENPSSDQQSGSPDDETKLGRPSIGDWMGTWWVKGKQNGRGPLLPQLGVAQDAGKEGHASSSQTPSSETSPLPSAPQTPNRAARRKASRSVFGTLGFSLLNPSVSSLGSRKRRNMSVTDIAAFEPRTETDVFKTRSAATSPSRSAFTTPPREVSPPPVASSSSTLAPSMSMSDQKPPQGSSLRAILQATRVMTSDPASVLADQGRDTSTFIANLALELVRNAREEGVEFRETAKERKERRTDKVDHYDPYATQQPPSHDADLTPIVNRTFSNDQARRPAQARKPSVNIPGFASPLFGSFMAQQQKISNVAGVVHNRASTDPSSAANTQTGTPALQATPSTKPGSVPLESIIPINAKPPTQFLSRTYTPLTSRDFHFTIPLPDTASGLSVLDEHNYEGMTDRYGFIYDVSQYDVLLLIRAKECQNTAPACLTGIKIADRKEDNSWPDENETPEETIEIVKAQCDCEGGDAADTVSVNTSSTRQTLYSIPTADSVSNSSQASRGASPSSSKGRRRRTLMGSSAPNGAASKRNSAILSVNAETPRHVCVHTIRRLLAQLIEIHDQRQTARRKEWDVFLKLRSNSTKGFSSTSRAIASGAGGGAAVLLGLDIALEEDELLHTDGLIGFAQLGLSSNRDEKKEFDKLVRNGIPLMYRSKAWLECSGGLEMREPGVFTDLLSEVDSENSVAREIEKDVGRTMPLNIFFGRTGAGVDKLRKVLIAYSRRNTAVGYCQGMNLVASTLLLVHADEEEAFWVLAAMVERILPEDFFSPSLLSSRACPLVLLDYVKELMPKLHSHLAELGVDLPAICFSWFLSLFTDCLPVETLFRVWDIFLVDGLDVLFRVAFAILHSNEQELLHCQSIPAVYVALESLPNRMWEADQLMQFEYDLRPTILHVEIVRRRNLHITELKQCMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G512</accession>
    <name>A0A401G512_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0101310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608171.1">
        <property type="nucleotide sequence ID" value="XM_027752370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G512"/>
    <dbReference type="STRING" id="139825.A0A401G512"/>
    <dbReference type="GeneID" id="38774175"/>
    <dbReference type="InParanoid" id="A0A401G512"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019569656" evidence="2">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12235" checksum="6D02560456E2A53C" modified="2019-05-08" version="1">MRSFFSVIILAVLVLLSSPTTASPAPSGVARRSAPSAVPRHQARSPQPSGAARRSIPEQESLVNHLCPSSMTACPISSSSSLASIPTSLAEWLEDGFECVDFSADLVSCGGCSSLDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5G0</accession>
    <name>A0A401G5G0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0102790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608319.1">
        <property type="nucleotide sequence ID" value="XM_027752518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5G0"/>
    <dbReference type="GeneID" id="38774323"/>
    <dbReference type="InParanoid" id="A0A401G5G0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8526" checksum="84CD7DAB56BE67B9" modified="2019-05-08" version="1">MRVNVVSQRLPAARQEGTDEKSFDDMFDRLLSRQDENRNPIGPEELTQTAEAITLLVHNVQVLTSLSSVVQCRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5I0</accession>
    <name>A0A401G5I0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0102950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608334.1">
        <property type="nucleotide sequence ID" value="XM_027752533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5I0"/>
    <dbReference type="GeneID" id="38774338"/>
    <dbReference type="InParanoid" id="A0A401G5I0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="152" mass="17002" checksum="F0128ACEA79D9280" modified="2019-05-08" version="1">MVEPKLKCNTRKCTATTEETGEPSKAKKPHGLNKLFEEVVKATFEETTKLAEYIARLELLNMHMKCDADRATMDKLQAQRALLKAETANMQADAARFQAETARLQAEKAFQGPVNYIMSLLTATGPLPYQWPGILGTKQQRGALPPRSCRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6M9</accession>
    <name>A0A401G6M9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0106890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608720.1">
        <property type="nucleotide sequence ID" value="XM_027752919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6M9"/>
    <dbReference type="GeneID" id="38774724"/>
    <dbReference type="InParanoid" id="A0A401G6M9"/>
    <dbReference type="OrthoDB" id="3222551at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="9166" checksum="3DF6D3757DAA8C31" modified="2019-05-08" version="1">MNHLPSVLPSTPALQDLTTTPDELQSQSAHAKVTNPKETAIFICALGQCNRLFPDRERLMKHRKRDHDSENQDDIITWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6N0</accession>
    <name>A0A401G6N0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0107080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608739.1">
        <property type="nucleotide sequence ID" value="XM_027752938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6N0"/>
    <dbReference type="STRING" id="139825.A0A401G6N0"/>
    <dbReference type="GeneID" id="38774743"/>
    <dbReference type="InParanoid" id="A0A401G6N0"/>
    <dbReference type="OrthoDB" id="4095724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019339590" evidence="2">
        <location>
            <begin position="24"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="15461" checksum="294E9D56E43DFBF0" modified="2019-05-08" version="1">MFTKTTLFVFSLLLAFFAVNATAEGVQKRQVDSVINSITSDIGSVASQATAGAASVFSDVTSFGGSIATIVTSAGGEAFTIVTSEGGKGITLATSGFGVVTTFAGSVYTEATGAGGSALTGSPTSTSGAQTFTFSMPLLTGLAVVLSGVFAGAWVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7K8</accession>
    <name>A0A401G7K8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein sym1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0110160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609046.1">
        <property type="nucleotide sequence ID" value="XM_027753245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7K8"/>
    <dbReference type="FunCoup" id="A0A401G7K8">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7K8"/>
    <dbReference type="GeneID" id="38775050"/>
    <dbReference type="InParanoid" id="A0A401G7K8"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23528" checksum="BF6ADA6056D6A1D3" modified="2019-05-08" version="1">MSHLYIALARVYQRSFASHPYGTLAFTNGVFNALGDAVAQVTEIVTGPQNHQGGGQQQYDPLRTLRFFAFGFGMGPLIGRWNFVLERHFPLRFHGGNSAKVSVPALAKRVAADQIMMAPLGLAIFIGSMGIMEGRDAKHISQKYSDLLMPLLITNWQVWPIAQLINFRFMPLPYRVPFQSGCGVFWTLYLSLLNSKESQMQNQADAMRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G958</accession>
    <name>A0A401G958_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0115640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609586.1">
        <property type="nucleotide sequence ID" value="XM_027753785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G958"/>
    <dbReference type="FunCoup" id="A0A401G958">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G958"/>
    <dbReference type="GeneID" id="38775590"/>
    <dbReference type="InParanoid" id="A0A401G958"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE78673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="210" mass="23153" checksum="A7A638FF999D2AFD" modified="2019-05-08" version="1">MPPPHYDFLIKLLLIGDSGVGKSCLLLRFCDDAWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWHANIEQHASEGVNKILIGNKSDWTDKRAVTEEQGRELANELGIKFMETSAKINEGVEEAFFTLARDIKTRLIDSQADAAAAAGGASSAEGSVKVNQPTSQTSGGCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9T0</accession>
    <name>A0A401G9T0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609812.1">
        <property type="nucleotide sequence ID" value="XM_027754011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9T0"/>
    <dbReference type="GeneID" id="38775816"/>
    <dbReference type="InParanoid" id="A0A401G9T0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="85" mass="9766" checksum="156F5095411A9098" modified="2019-05-08" version="1">MSSMQTLLLLLNYRKLRLIALRPRRTVLSSEAAVDGPEISGSRHFLLQTIQIWLHCPTASPVEVEMWDQRGSWMYASPVISDQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA17</accession>
    <name>A0A401GA17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0202090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609925.1">
        <property type="nucleotide sequence ID" value="XM_027754124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA17"/>
    <dbReference type="FunCoup" id="A0A401GA17">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA17"/>
    <dbReference type="GeneID" id="38775929"/>
    <dbReference type="InParanoid" id="A0A401GA17"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="227" mass="25214" checksum="D8901930B938831D" modified="2019-05-08" version="1">MVVQHAHTSQTTPASLPPSVFTLPQTAQLEALYTIIRDKTTSRGDFLFYSDRIIRLLVEEGLNHLPVIPKTVETPTGATYEGVGFEGKICGVSILRAGEAMEAGLREVCRSVRIGKILIQRDEETAQPKLFYSKLPQDIKQRYVLLLDPMLATGGSAMKAVEVIMEQGVPEERIIFINLIASPEGLRAFCTRYPTLRVITGWIDEGLNEKAYIVPGLGDFGERRYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA66</accession>
    <name>A0A401GA66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0202200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609936.1">
        <property type="nucleotide sequence ID" value="XM_027754135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA66"/>
    <dbReference type="GeneID" id="38775940"/>
    <dbReference type="InParanoid" id="A0A401GA66"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="382" mass="42464" checksum="71B80396561BA552" modified="2019-05-08" version="1">MKVSLPLDRTRKSTCSVALKKKSYVDVDVDDDDLRGIKVEKDSDANLDDSSVVEIESDAALPVTDSGILGTPKKGRRDIFTPQLTPKMSSPVKSKSSIAHTSERRAQCSDASDIAPSYCISYKEVTSDEVDIELHTPTKSKPVPIAKVSKGKLILRPSDIHGDIHTCEAYSGCATLADKDDYEETDDDAMLVSLKSIANMSSNELHALMAMIDASMQTPKTKVDQYMEKNVKKVQSSDKESEGDISPMKIDGAKNGKDYDSSNTNDNNNIADDSDTLEDDDADEDDEDQNHDKKMRKGEVKGKKMFKYIDEDEDEDGNLKVRKSGAKGKRVLREEDKDNEEEADEKVWKNEEKGKRMSTMTMSAEVNTVSDDIKKLMQAYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA71</accession>
    <name>A0A401GA71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0202620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609978.1">
        <property type="nucleotide sequence ID" value="XM_027754177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA71"/>
    <dbReference type="GeneID" id="38775982"/>
    <dbReference type="InParanoid" id="A0A401GA71"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="3">
        <location>
            <begin position="2"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="655"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="696" mass="79996" checksum="EF8282FB0BAAED42" modified="2019-05-08" version="1">MSRYYITELYGGSFVQTFPTISKERVDMHGVNDFMMLPIVYHPHAPQNPGDPGLFYMQSARVFEWKEVRRVFVALRPGVWSHVGFYKMFPSEPLTADEFQRQDGKVKRTWAEQILLKGWGEDIRLRVWWRQRNDEELSDEEIDVMISDKDIMKTVKEQVKDISAAYERGEEQIGVWCMKCVGYDAKFQRILVNNYDNFIPPSQKNKDRKKKVSAKPKGGKGKAKIPSSEASYSRAASKRKRAQTEAESSDEEATDEDMARQAPGPAHNGRAEFKMGPFYCSISPLRSELCYFTLYDWAASQYKLRSQVLYNVPSLVLAICSRPMSRGFTLGPHSGAEKYNPADQELSHSYNLRVLLHEYKQLTPEQVDFFLENGYVVIKQGFTKEKATEFTKTMWVRLALDPNDKSTWDRERIHMPWHSRQPVASFAPKVWEAMQDLLGGAERIDEPSGSWGDSFIVNFGTPELEGPDKYVDPHDLDNWHVDGDFFVHYLDSPEQALLVIPLFSDIKPRGGGTFISPDAIDMIAKYLSQHPEGVLPTGLSFTPSTSTYEEPKDDPGYWSHPEEVKKCKRFVEMTGEIGDVVLMHPLMLHSASKNHLREVRIITNPPVSLRKPFNFARDDPEEYSIVERKTLKALGVDKFEFKPTTERRRLVPKRFVQHNKMLEEERQRLEALKLDKEELEKANVNVSSVSQPIAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAE5</accession>
    <name>A0A401GAE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0203350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610051.1">
        <property type="nucleotide sequence ID" value="XM_027754250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAE5"/>
    <dbReference type="STRING" id="139825.A0A401GAE5"/>
    <dbReference type="GeneID" id="38776055"/>
    <dbReference type="InParanoid" id="A0A401GAE5"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="138"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="208" mass="24115" checksum="F2698E7DA7F10290" modified="2019-05-08" version="1">MTKSRASKSESKLTSGNLPSSEPAAEISEEDQQRIITESGILNRLRVREDEDESVIRRRQQDEDEDEDRLPLAEEVFNATLLIIPMASLLFLMEILVHWQYGRKPTYRALAERMLSGIPILSIFVFYTNRYKQHRRLQLLLFILSMVVGTRLIWLINRASWRVVMRQCPPLATLWVYCVLQLELAPATLGLIVVGAWVWAKDMKIFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAW4</accession>
    <name>A0A401GAW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610212.1">
        <property type="nucleotide sequence ID" value="XM_027754411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAW4"/>
    <dbReference type="STRING" id="139825.A0A401GAW4"/>
    <dbReference type="GeneID" id="38776216"/>
    <dbReference type="InParanoid" id="A0A401GAW4"/>
    <dbReference type="OrthoDB" id="3233824at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="280" mass="30330" checksum="0227657708CB67C4" modified="2019-05-08" version="1">MNTLPSFVELMASLGLDNCPTTPAGGSACHHSRSSSRSSTSSLHSEASSSVATPPPSTIYFNASPAILVSSHDGPSAYRERERERRRSPSYAVRYAPYGPSISHTRKGSASNITDDELSQERHIRPFSPAYLSSPSHVVGRRASSWTLRSTSKRPDKLALSDTDLTANTPISTLVRRKTPQASPTSPTFAHRTKRRSCSPAFPMSIPSLPHVFPPSPTANGFDSDPEDDDMEVTPKTSSYNARRPSHNSRPMYDDCGVRISALSRPGGLESQQNCMAPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBH5</accession>
    <name>A0A401GBH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0207010</name>
        <name evidence="2" type="ORF">SCP_0207140</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610414.1">
        <property type="nucleotide sequence ID" value="XM_027754613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBH5"/>
    <dbReference type="GeneID" id="38776418"/>
    <dbReference type="InParanoid" id="A0A401GBH5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="253" mass="27038" checksum="E94E9F4BB1135076" modified="2019-05-08" version="1">MAPNRLIEDLSARHNLPAMASDAEPPDTLDITMGKLDEEDSIAEPRRPLISDLLDSPGSAQISLPLHSASQTPLVPRHTTPSLAALFAPSNSPHEHLHRHASPKVQASSGSVAPVERSRALIPDPLAPAWDESRGSSPIHRRALISDSTPTAPGGMFDFDTPGISPIPRRALLEATPLPPPAHTFDFCTPDTSQLPRRSLIAEPLDATPCTSIHFDSQASTPMARGMLVDETLDAEPVLKLLDFDNSPPAMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCE8</accession>
    <name>A0A401GCE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein IMPACT homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0210260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610738.1">
        <property type="nucleotide sequence ID" value="XM_027754937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCE8"/>
    <dbReference type="FunCoup" id="A0A401GCE8">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCE8"/>
    <dbReference type="GeneID" id="38776742"/>
    <dbReference type="InParanoid" id="A0A401GCE8"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF24">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="36"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="364" mass="39902" checksum="4BC91B2345724EBA" modified="2019-05-08" version="1">MIPLTLSPSLSSPQYQSIDELVAQLSVDPQCEAIASELGVLQSIYGEDAIQLWHPCTPRERARDEYEQGPRNGEPGSIRYEVALNVSPPSDPSITYPLTILVSLPPAYPASAMPQLQLLSRYVGPYGVDAALFGTVLRTYISKGGVEIVPGEVCVFDGVEWVKEKCAEWVGERMSAVKVEEIMRESEKECLSDIDGEAEQVSKGKAEILMVPTRIPDGVEIVEAEPIVDRKSVFIGRACRITDPSQVEMILAHLMSDRRIARATHPIINAWRCRVGNVLHQDNDDDGESAAGGRLSHLLQILEVDNVLVVVTRYFGGIHLGPDRFKHINQAARNALELGGFLDNGEGSSSTNGRRRGKAGHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCP7</accession>
    <name>A0A401GCP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610824.1">
        <property type="nucleotide sequence ID" value="XM_027755023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCP7"/>
    <dbReference type="STRING" id="139825.A0A401GCP7"/>
    <dbReference type="GeneID" id="38776828"/>
    <dbReference type="InParanoid" id="A0A401GCP7"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19597" checksum="F693B2522BD3CC05" modified="2019-05-08" version="1">MCSLSSTSSSAAPGHEIIIVPDVGEPGRQELRQQCYDVRIDVFHHEQKFPLDTEIDDLDETATHILLRLVPSLTPIGTIRCSRNDTQGYYKLSRLAVLQDYRQYRFGRKLVLALHDYVRQDLAQCGRASTTVKAHSQIPVKGFYAKFGYSPEGDEFDEDGAPHQLMVARVSLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCQ5</accession>
    <name>A0A401GCQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610881.1">
        <property type="nucleotide sequence ID" value="XM_027755080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCQ5"/>
    <dbReference type="STRING" id="139825.A0A401GCQ5"/>
    <dbReference type="GeneID" id="38776885"/>
    <dbReference type="InParanoid" id="A0A401GCQ5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="929" mass="99242" checksum="2BD715E6863F02A4" modified="2019-05-08" version="1">MPLDIDPNYVLQAAQLTAIVAAAPRQDDPCYPDWETRIYLEVSRLEKSFPQPLKSLRMPGIVISALLEFTQTYQQKALARLDHISNDDERIYKRYPPAVREYGECEDLGRQWWTEDPYCKLPPVKSTPAEGWGNVPADDDTQGRGEEDLATGDLITKGKGKERADNDVGTGMVGERIVHVEAGEDKGKGKSKEKAQGKAVHAMSEEEDGGEGEGEGEEQEGEDDDDADSDEDDDADKDDDDEMAEDVPGAGQPESIEVDAASPPPPTARPISISPAAPSLRKRKAVITESSEESENEEAAPKAKRMKPIEVAKEKGEAPTTSGRAQRAQKRMAQTEVEGSKVSTKKSGKRKAKESSDEEEVPTVKPPKKKCATKEYKSKEFIESEDETPAPPSNLPAKIAGDSNDGVAKTNAPAKPVKQTTRMTVTPHVAPKAKAKGKAKATAKGKATVKAKAKVTVLQKDMWKKMSTRVSDFMWAHATDSLVPCVGCQEKEWPCKLNTANFGRCLECAARGREFQEMCAALVVEGKPLPTSPPPYNVKVDSDEPDSAEPMVMGASKRKPPKKTKMRNAAASSSKVKGGEEVEATKQKATVMPYEANAEGEASVEKSSKSKCATKSTTATGAVALSNSGEVSKSGAPAKSGAVAKPGEGKKSGPKAKPVRSQNSGAQDGGEVTRTSVREPDEVPPAKSVAKEGGQTTRVVMGGRSGPMVPVITRKAKVSAPKAAAKMPLVEGDGMEEAARLAMEAVRAMAFQTGPAAPPQASSSKRMLTPVADEPEDAPEYQAEVAEDERASLERPHDDRWRSLLMPHEMSAGAAEVAQEVTPSLEISKASKGAKSSTLAKAGHLNEGRRPAKRGAPLDRKAAKKEAEAKRDAKANRLRAVPPTSKAPHLRDIQRVSTGSPAPVNEGDTPSGEETSQSSNDDCANCAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCX3</accession>
    <name>A0A401GCX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0212380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610949.1">
        <property type="nucleotide sequence ID" value="XM_027755148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCX3"/>
    <dbReference type="STRING" id="139825.A0A401GCX3"/>
    <dbReference type="GeneID" id="38776953"/>
    <dbReference type="InParanoid" id="A0A401GCX3"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="236"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="527" mass="57837" checksum="50F69FCD867648E9" modified="2019-05-08" version="1">MKHNTTDRAAKELEDAFIKVTFEEDGHGAGAQSTEAFYDTWVDHVSAKFSDAATYGAIALQKLYPEHSIVLSTDRGIDILSFPSAAFLPMSPTETVSSVYFVPFARRLGQIPGILVNMIRFAAFHVSWDAYDFILYIVRYPQGISEIVQHYVLHEGPEEHSRALLVAAGAWQNQLHDEILVFNQGLWRKNHELWMEVQKANWGDVILKESFKTALQKDVRGFFDSEELYKSLSVPWKRGLILHGPPGNGKTISVKAIMKDCDARGYATLYVKSFKSYMGEEGSMAAVFSKAREMAPCVIVLEDLDSLINDANRSFFLNQLDGLEGNDGLLVIGSTNHFDKLDPALSGRPSRFDRKYPFEDPDQDERALYARYWQGKLKSNHSVSFPDSLVDEVASATDGFSFAYLKEAFVSALVLLAGDKGDEKPVFATVLLGQIKSLRDQLKKQPHSAGAQSATGDVRHVRISGGSAAGGSDGLPASCLTLAGRIWSAGESKQARTSVMPGGMPGMGAALEGRPHATLAALGRSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD32</accession>
    <name>A0A401GD32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0212970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611007.1">
        <property type="nucleotide sequence ID" value="XM_027755206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD32"/>
    <dbReference type="GeneID" id="38777011"/>
    <dbReference type="InParanoid" id="A0A401GD32"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="66" mass="7121" checksum="482C663E5A14B6FF" modified="2019-05-08" version="1">MKSTAAVLTCQKEATDWPLSSKPVICVSAMDSAFTVCPGDDLDKSSHDKELGSSVHTHRQLFSIPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDF5</accession>
    <name>A0A401GDF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0213560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611066.1">
        <property type="nucleotide sequence ID" value="XM_027755265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDF5"/>
    <dbReference type="STRING" id="139825.A0A401GDF5"/>
    <dbReference type="GeneID" id="38777070"/>
    <dbReference type="InParanoid" id="A0A401GDF5"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="221" mass="24717" checksum="0DB64EF0BD221932" modified="2019-05-08" version="1">MVNPEDPALLDLGTIEVRIFRVNKEKPTGKPIAPNTPTERGPVHERCKKAGTHHVSYGEATKIEKRQYYKPTWIDPQSQPYATFRLRYRPRELLRARGIIVDRADIHDEPSSSGSHPSADTAETYESDSDVVVLDGPPSKKRRINSSTSVDVKPTIDVDALDADGTDDTGDDLDVATIAEQIRSLTKQLERKLRKKKRTVTGARGKKAKKEKLEEIDVHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDP6</accession>
    <name>A0A401GDP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611209.1">
        <property type="nucleotide sequence ID" value="XM_027755408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDP6"/>
    <dbReference type="GeneID" id="38777213"/>
    <dbReference type="InParanoid" id="A0A401GDP6"/>
    <dbReference type="OrthoDB" id="5410365at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="85" mass="9224" checksum="30022AF2B6510341" modified="2019-05-08" version="1">MQSTASLGANILPSTALLRTVVPRNAENVLPELLKDEAIRAWIRIQGSMKLYLITGIKLFVDAHVSTGEGSDMDARVAATFPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GED1</accession>
    <name>A0A401GED1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase A</fullName>
            <ecNumber evidence="6">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0302510</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611449.1">
        <property type="nucleotide sequence ID" value="XM_027755648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GED1"/>
    <dbReference type="STRING" id="139825.A0A401GED1"/>
    <dbReference type="GeneID" id="38777453"/>
    <dbReference type="InParanoid" id="A0A401GED1"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019208002" description="Beta-mannosidase A" evidence="14">
        <location>
            <begin position="20"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="17">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="16">
        <location>
            <begin position="770"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="15">
        <location>
            <begin position="866"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE80536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="957" mass="106672" checksum="82AF97B498C61B29" modified="2019-05-08" version="1">MLSLLRALVAVCLPTLALAEVFSLSDLQWTLRNGNGSIVIPAKVPSQAHLDLLDAGIITEPLLGINALAVDYTQRWIANDSWTYTADLTPFTRALSPNVNKSTLLVFYGLDTIANITVAGHPVAWVDNQFRQYVYDVSELIASPSAGDTNVTVAFESAYFYGMNVTSLPDTEYSPTGDFEYVGIRQWIRKIQSDFGWDWGPAFVPAGIFKPAYLVTLSDTPSYQFMPAEYPLLASMSGSIFFDQYSLEISKVGQTALIAPNETADWLVNVTLAVRSVVAGESPAISLAIPELGVFAEPVSVSPIPASTADYTLVSATFTILDEVPERWYPHDLGTPKLYDFTISLALGEASDAPHASFNARSGFRTIQLMQLAYSEEDIETRGITPGDMWHFEVNGHEFFTKGTNIIPFDPFYARITTEKVRWVLEGAVRSGQNMLRVWGGGIYQPSDEITGVYDFYSLCDELGILAWSEMIFSDATYPLNSFLLDSVDPEVRQNVRRVNKHPSNVQWAGGNEIENIVIGINETLANGSHYLDEYIYLFQDLLYNITYEEESSVPYTDCSTTNGVLSLDPYVLRFENKTPGYIYGNTERYNYDASQAFNYSTYPVARFVNEFGFHSMPSFYSWEEALLNAEDYAFNSTVVVSRDHHPPANGLTWPNPNAPQGQGQMTMGVELWLPTPYTTDTNQTFAQWCWSTQIFQSMNMISEIAWYRRGAGLGENNLGALVWQLNDIWQGVSWASIEYSGRWKVLNYGMTSIYSPVVVYPFWTPDNQTLDIMVINDRWYTVNGSAQLTWYDWSGTELLTMTHEFSTPTLNNTVLMSQEGFDTILPTGANAEDAWMLLNLTAEVDGRTVTNEQYYTPVSLAYANLVDPEIAVTTGPGLTFTLSAKGGVAAYAWIDHPSSTVGYFVDPATDVPLNGFYLVPGIDRTVQFLLNPALSLTTNPDPADFVVRSVWNNTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEP4</accession>
    <name>A0A401GEP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0303540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611550.1">
        <property type="nucleotide sequence ID" value="XM_027755749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEP4"/>
    <dbReference type="STRING" id="139825.A0A401GEP4"/>
    <dbReference type="GeneID" id="38777554"/>
    <dbReference type="InParanoid" id="A0A401GEP4"/>
    <dbReference type="OrthoDB" id="2803524at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="776" mass="83282" checksum="4453A259D7E924E6" modified="2019-05-08" version="1">MPQKSWATEAETVLLTSLRPSFLEHQKCRTLTKFWASLNTEFFQRFPERVKLFGPDISDSMLSEEQRTALGEAIKKRQSISNTQLKTWFNWRRPNNARKVARVTPITMESLGMKPKHRVLKEQEEYSRRFYKDRIESHVKAALEREKPTCHESLNVINRVTDEWFEQEEDWVRKQVLDAIEASKKQSDEKSCGGDTERSPRQYQQAINDMPIILKQVFSELAADSGWDITVIAGGPCPDEGGDIVTIASHSGTTETGHTFGDIHPGIMTNVMDTFIEHLKAVYPSDVQRHRALDLSDESAADSLPSAAGPSSAGTGRVATPELHPLHGMSTEDSRRASGDNFSETPAVPPCPSEHASPFPPSLPALSRSPSPLLPSLSLPSSSEFVASLTGLPQSPIPMPQIPHPSLSNVMNTSGYASSNFDLAGHASTTSVENDVLLQVPLNGWGAAWLLPSGLGGEQIPWPDFDVGTWTPDTTNWVINELGAGPLDLVDSAAPAAISGAWGHVDGVPLQPNQGSRLGDASDTGNMVSGAHEPGPHIATSPTDIANLGMLSVVQDRPIVLPATSDTASSSMFRFPVPPPAYVIPMHALTAAAINTSSRTSSDAVSVPADIVQSGIDASAERDALRHSEVHSAPIIQPVPVSAVPTIVQPADHVAPVHSINTFSPPSVDLDGTATSAVPSSTSTSTSCSSSPIDLDGTATSTAPSASNSCSSLARPSRTRKLPPTADSIWEPTAAQARRLGISTMESDSAKPKRKSAKENKVEMGEGNDGVKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF06</accession>
    <name>A0A401GF06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0304680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611662.1">
        <property type="nucleotide sequence ID" value="XM_027755861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF06"/>
    <dbReference type="GeneID" id="38777666"/>
    <dbReference type="InParanoid" id="A0A401GF06"/>
    <dbReference type="OrthoDB" id="2653987at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="28307" checksum="FFE3FF804A7E3AAC" modified="2019-05-08" version="1">MPAKATQEPKSKDYTATVRELDATKSGAQDDAMRQAVLAVVQIWLNRLALVSGITTFFASIDSLLFSLASTATHIGDPDTSGWNAIDKLTTASFAGALIFHVCSAIVAFAGSFVLVRLQLVDADQQEHEAGIPAIYAEPMREVSDMRENSLSLDNTLRPSDTFNAAHAGQPQWRAAYNGIYSRVVIRRLVAKRPKGPVDSLLDPGPPVELLSRCNALAVVMAVLGFILAVLGILAYAWTATPLSVSIFSSACLGGCIIATCIAIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF17</accession>
    <name>A0A401GF17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0304910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611685.1">
        <property type="nucleotide sequence ID" value="XM_027755884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF17"/>
    <dbReference type="GeneID" id="38777689"/>
    <dbReference type="InParanoid" id="A0A401GF17"/>
    <dbReference type="OrthoDB" id="10688479at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="922" mass="98651" checksum="F0449E0869D2C451" modified="2019-05-08" version="1">MLIVPLLLAATLALYGSFSTPLFATLRANMREQLYRPVLSSIKLAAGLIFTPLSALVSPHSLSSSPMHDGRADHLSMTTDLIVRPLTDIVPLYSPISTSKAPLQVPLLTGGRHVTIFDIYRRFPWAEIGATFLVASLLVAAALFMIVQLAKLSIFKIDRAPHTESSSFPIVVSHDFTNASVSSMPSNFGSELFGFPGPRLELEAPVTACDLSVVISPLDVYHTGCIILKPHDLPLCTATELDEEPVNGGTDHILPQSQVISTSPYPDNVPIPDHQDGFMTPNLEGIHSVSEHVDESTQTACNDEESECFFYPGGMEDIYNKLLQAIGRSLPPGCNNEDLTQNILTLLSDSLSTVITGDTAAPIPIQAINTPGEVLRGILTLVRHILMPSTTAEETEETTAPIATEVVNTNPGHIHGTTPLTSDTSSSAMIDETPAPILTEAVDTDPSAIGGDTTAPNFGLDDIPESTTHVIPKSTHVIPESTQIIPESTQIIPESTQIIPKSTQIIPESTQIIPESTQIIPQELPSEGLEASDWAPGGRYRARISGSTHAIPLKASTGTRVPVNVPSGGLQDSRRAPRNYDRDGLSEESTPLEERAGARTPVFASTATCSGTPRNPIRRARENRGARGSYQRQRQAVESQAGPSAPASVSLAQSSSSADLTHPHEKSRGPGGNRTQTLDPHTDARVDPGASTSAFPPAEPPAFQKTGNSRGNCNWAEDVRLQREASASSSSKPRLPSSIDGSMRAIERKAQVGGSTHVGHTASRQIVQDHPPSENGQGEGGDGDGYVIYSTPYPNAKTSNGSRSAATPSNVTHGSTHYDMNNVLYETGPSRAPPSELHSEGPRDSMQAPDEGEKAPDDGGENRNGGHEGYVTTDTRRAGMRGQEHREGSSERSIRGRVRTRSLDEGNSDRPFRRSPDHRNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGI1</accession>
    <name>A0A401GGI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612209.1">
        <property type="nucleotide sequence ID" value="XM_027756408.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGI1"/>
    <dbReference type="GeneID" id="38778213"/>
    <dbReference type="InParanoid" id="A0A401GGI1"/>
    <dbReference type="OrthoDB" id="2804229at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1550"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1180"/>
        </location>
    </feature>
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        <location>
            <begin position="1199"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1225"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1264"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1304"/>
        </location>
    </feature>
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        <location>
            <begin position="1305"/>
            <end position="1316"/>
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    </feature>
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        <location>
            <begin position="1328"/>
            <end position="1359"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1687"/>
            <end position="1700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1732" mass="187074" checksum="A8EBFF0A7EAC8FC7" modified="2019-05-08" version="1">MSTPFATPGMSGIRESRHESSSRSILRKLGRAPIYNPYDKFTQPEFDAWIGDITSALRSALGKEEPQSGPTKQREHADRESSSQDEREYVVEDSFAELRARREAKGKERAQDVGSEEEPIVLSDSEEEQGNADQLDENWGPVFNAEGYQAEYDEGEEPDSDAENEHRSISAEIIELSSDEEEIAKDAGSEEEDSGSEKEMAEVEDDVGSEEEDAGSEEEAERGDFAEDDAVDERAYSSLLGVHHDEEVEDEVPLIDDESEDEQVGEEDELFPPEENSHQPADLSDPWVGPSTYAEDFYSGGDVPSIALEHGDPHNLPTEENIELLEEDVGSDGSEEEGSDTNSEDERSKSVEVIDVDEPDELDKEIEHNAPQHPVDLPDPWSGPRTFAEDFYSGGELRESNLRARRLSPSHLTPMLSRKGSPAAVGAPQASPSTIQESYEDAHKQRRTSPLFADTEAYPALEDVHDTVPDAVGPFNVDEMFDDLYADLEKAVQGPDTHWDESVVSAGTSLGQGTHEHDAVVDWNAPIAPESADTKSALDHAFRKHEVLEVDDDEADHTAPLQKSQYVTNATNVEQHNREHQVPTENLVEFTATPAQESESFPRIISTTPAVVRPEPVKDEEEPVEMSLHDSVAPSVDTWNIPAGTGSAVHPPPDLAAGADDHDKVSAAEIQPAEGSFPKQSSPELVPEAEEGSEFTSGSRFGKDSVPGYSDTSVEHAAAPLSEEFAGIYEDDEPIIAVVTEAESDDDQHSELEEFDAETVIVVDESGAAEVEYTVEEPITDGRRTEEPEDVELGSVDVIVEDARAYETEETPPLHTPLHEQDIAASVDPGPQEGSVTGLTGKDKVVPEVVAQSLDSGENFDFAQLQYPIQDTDEPDTLDALQAQHDRSSEQHLDFGVPMPIYADPSVPDPASPRADSDALSGNGSQSGGTPAERALSIGLPVGSGLTSRGDTPAGLFTPLIADDSLPASPRTRNVELRDPERAFGRATAGFEVSTKSATLQAVRTTLFGPPSLSGQPIPADVGTSTKVSAHERRNTTEDHDIVEGNVIAYDRISAVDATASVSAVPEGPDGFDKAASPPSADDQNVEDVPSLASMIDSKNLGAPAGVELAPTPEVLRHSSPQEGTHDTDAEGEVDPDYEGRHEDTLPGPSSPHVIHYIPAAAKDADPFVLASSSSPSAPAMNGDSSAGVDVKCQEASHDLTTQRQSYTDRANGARAKTTPAEGTESPTAQSNDLSQKDETANASSTANPRQLRLLKRKRKSPVEASTRTTRSMARNISDGEPPPAQPSEGKGKQKAVENDHEDGSSPTCESVSGESKTNDDSKALAASSHTNSRASSIASTVPSNDWTNPPTSPATVRNANPAGFHQQYSLPFIHAHGVMRHHHGRPALHVQLPLPPQAVQPSNSISLSISPVDQGPTTETNFVEQLSPSQRVAPRPETGSPVTRSNCRFHKISLPREENGPRIYFAVPGCSLGDRDLMEQEHIEDHGPATHDANTRLVADIESVDFSPYLLGILRQLVGVDLLREQEVFYLPQQGERYKFKHKRKSRVAKMRLSQGGPLEHAVSQSPRLSMTPRLSAMRPPPSRAGSISTSGGSARRGSRPTTSSISESGLSDADDGDLPATKRQRGSSNSVEVEVETADSTAKASIVVSRRLVPRRGKKLGADAAAYKPEEDHPESSEVEAENRRTKRRKGGKKGVKRTRAEDPPDEQATIQPKKRKVRASSSEKTEDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH78</accession>
    <name>A0A401GH78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312410</name>
        <name evidence="3" type="ORF">SCP_0312560</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612425.1">
        <property type="nucleotide sequence ID" value="XM_027756624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH78"/>
    <dbReference type="GeneID" id="38778429"/>
    <dbReference type="InParanoid" id="A0A401GH78"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KOW" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="187" mass="20582" checksum="429765F0803FA2CE" modified="2019-05-08" version="1">MLPALLKELFREAVTESEGDRLIHILKGKKFKGGLLQLELTLDRVTFDVHATRNDVFVFNAVKFVPKTAIVKLILFCVDFEPAAGTCVIVIQGKQCGLIGVVHSVINGQAMLTNLYHEKLDDELSSLMLPVTQLHPLWAVGDAVKVKTGLHAGLEGQVIAMDDFDVTIVHANKVEHVCSTYDNASKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHM6</accession>
    <name>A0A401GHM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0313500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612534.1">
        <property type="nucleotide sequence ID" value="XM_027756733.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHM6"/>
    <dbReference type="GeneID" id="38778538"/>
    <dbReference type="InParanoid" id="A0A401GHM6"/>
    <dbReference type="OrthoDB" id="3357439at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1181"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1508"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1399"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1573" mass="170868" checksum="338EF05ADA02074B" modified="2019-05-08" version="1">MEGQKRKRESDTAIVTYHVRDRSFQRVFKETTLAETKDTIRQKLGIPPDTPVQLVQIQGGRRVDLEDDDDFEAFRALSLTESRLEVSVSVDVPGHPVTDSTHLGSVSGTSAMQRKKKKGKSAAALQLSVGPTGSSVSTGNVPRSISVDLAGDERPPSKRRKADTAQISRLQTEPSRLLSANSVVREQHERTNAAADSALNAPNLSMYVSPLKRRKSAKSLKGTPDAKRTVRQDVQEVSGPAEPPMKKRKHQSMFSFEITNGDVPVSTGSTLSDITEPSIAAERTSSPKKKSKKMKPAPEPVAGPSTERSAPAAPVENSDDTVKKQRKSKKETPVDNALKKQQKSTKETPVVDELTLPPSDVSELLPEKKGRKRKDSEVIAEASVPDDTARALQSAPPTAEDESSTTGKVKKSKKAIGKAVAEAPALPDVTQELPNGVKKTKGKGKQKAAESAVPEAPEHLVHPAEEVPTPVSTASPPAGTSEGQAEAPADTAKTKPVRKTRQPRKSAVKRSEESPEEGFVRVHAAVAAILHRKANIAPAPAAVSEPTHAEERPKQPEVLQIPKKQKAGKSKLSMSWRPEESTQEPAAVGLQKDTSSVRKMSTPKASSPTIEPGATKRRVSTSSKKGSQTKDILCPVCDQTPFHLRYQCPVVLAGAESIRKRIAELRDTDTDEVVIDELQVLLGRAEKKSATHDRSSPTAEPVPESPDAAKQSKAREPSPPSRRSSALLSKSPSTRTPVIPTGSEIAEVAVERQDEGSSNESSDTESEEESDDDARTIPKPTLLPLPRKVDTLNTNLGNSDIAALLRGPARSTSSVLAQIPSESSSEDDDADEEDNRMEDEDDDEDEDEKQDKAYRRLSRRFEPAESSSDEDAQPDTALADDDDVVPPTFMDTDPQDAVIKQNTDKVEVVALAKVLDRDNTCESSDTPEVPKESDKAVGAEAEQEVEDKPMDNTQRVPSPAEEDDEEVATSLDLPAPSPGTDNAEEVDEKVDAQDTSEDAVHGTTTVHSPVIEEAPLPELFVKAASVVERRSASMPIPEPEQVEVNDARSTATESAEQPAQRGGDDKEDEEIELEDEWELTDGASQSKPKALEQQELAEKEHEEVSDPIETTDEILVPETQEEDPIEAGSSSPHTPRRQSTQPPPLSNPRSGTIKRMKDRYGRLPHLSENLPILASAFVTSTPMPAGKETTPDTPAVFQTQTTEESVPRGVRQSNQRSKSAVLMPPPPEPSPAPALKRRGRPPMPVEEKERRAAEKAEKKKIAAEKAEKTRLERAEKVRKREEEKAEKTRKREEEKAEKVRQREEKAQAKKGEKPARVTSHPVVPVITTPAKAFPKSVAPPSQRPEAQSAVKWTTLTESPSIIEPESSMIDELRSSSPGGDLLPASSSVADELLGVDNIVEARERTSGDSQPHETSENAIDPDPLFLPGTQYPESPLFPPATVLGNRLESSASSSSSESEDEDAQVVPQPKLRHAWMQSAPFHRLSDLQSQQLFSQLPVTHMALKPSRTVAKLSGALPRGSDDDDDDDDDDDDTEDSDSDQGSEVQTKSHIPQERRAGAGVQKKKRSGLELFEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHV0</accession>
    <name>A0A401GHV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0401100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612652.1">
        <property type="nucleotide sequence ID" value="XM_027756851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHV0"/>
    <dbReference type="FunCoup" id="A0A401GHV0">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHV0"/>
    <dbReference type="GeneID" id="38778656"/>
    <dbReference type="InParanoid" id="A0A401GHV0"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="211" mass="22196" checksum="E7FFBE48D093C94B" modified="2019-05-08" version="1">MSSIKGPAAPDAKFDGSPLRIAIVHSRWNKTVIDALVTGAVTKLREQGVKDSNIVIQSVPGSFELPLACSKVIAGSHVQAGATATDLLGGLYLGSFTSPRPPSRSSTPAPALVNMPSQPFDAVIAIGVLIKGSTMHFEYICDSVSHALMRVQLDTGVPVIFGVLTALTDDQALDRAGLGRGAEKGHNHGEDWAAAAVEMASHTRRWTEGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI45</accession>
    <name>A0A401GI45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0402130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612752.1">
        <property type="nucleotide sequence ID" value="XM_027756951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI45"/>
    <dbReference type="GeneID" id="38778756"/>
    <dbReference type="InParanoid" id="A0A401GI45"/>
    <dbReference type="OrthoDB" id="2769475at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="477" mass="53999" checksum="C1FC5A0ECD3DAF0A" modified="2019-05-08" version="1">MSLHLGGTVGLEVTPAKNLPEDIIREIFKCGWSNSAPSMRLQFSLLVASVCRRWRIAALDSSSLWSTLVLIISYDPSLEILALFLSRSHSAPLDIIIITHRRVKNNNRLHREPDITKGIFRLLLPHMGRWKSLSLSALTGASLGYVNSSLRGCANVLEKLRVTYTGPIDFSSPSHPQRAPFHSSFKASNLRELTLQYVVSLPDSPIDELFPALELLSLDKSAPLTLQWREFVQMLARLGHLRVFHLGGGRRHIMDLEEDPGTPPRVTLAALEELSVSDLWHENVNEMFSFFSAPRLAHFSYIDPRDWSDGSEPVIENHLEFFPALRSVTLANSRGEIDVDYDCLSQLVEHFHHVNIRGLEYAPNHVIRAAGDRQIDPTELPLARLISISLRSCLQMYIEELRELVLVRSDPTLAAEYGEDAPTALEEIRIYNDCEIGEEDRAFFTNNLRVFEWLPYAADKERRPSGSVDMVFKPRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIF6</accession>
    <name>A0A401GIF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">SCP_0403330</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612870.1">
        <property type="nucleotide sequence ID" value="XM_027757069.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIF6"/>
    <dbReference type="GeneID" id="38778874"/>
    <dbReference type="InParanoid" id="A0A401GIF6"/>
    <dbReference type="OrthoDB" id="7691805at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="527"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="768"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="799"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GBE81957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1435" mass="160356" checksum="33DC5EC326FA4A5F" modified="2019-05-08" version="1">MSLYPPISQASSKAESKRLYDVPFLESNGGNFQTWKYRTTTILRLRGLYSLIDGTEADPGTVDTMKKAEWDVRNNEALAQITLTLKDEPLNGVMYSMTAQDAWEKLNRRYEGRGKQTLAYLISDLFRSTLSDELPLEPQLNTMQQKAHILETLGLTLDDTLIAIAMAISLPPSYSTLRTILMASDSKLTVEKVVNEVLSEEKRRGETTAASALIAKHADTKSKSKGKDKDKKKKGKCAFCGYTGHTKDECRKFKVSQVEGATAKGDKKAEKAADAKESAKIASVGEADSETLRLFVAEELARGDDLHRWIVDSGASSHMTSHREWFVNYRALATPKRVYLGDERFILAVGIGQVTLRAAVDHGSTNTGIVQEVLHVPDLNGNLLSVSKFDRNSYDVRFADGTCRISNAQGRLSATGYMRRNLYVLDVTTQLPECTYILQAKDLPPSYDDSMDDPPLHAFVAKETTSSASAQVWHRRLGHISVDSVLKMVRKGMVKGMSIVGEKVSNVTCKPCLHGKQTRQPIPKESDVENPRILHRTYSDVCGPMQTQTRSGHRYFITFIDGHTHHLVANLMKTKDEALSHFKAFVERAEVETGQRANILRTDGGGEYESKEFEAYLKEKGIHHEKMNAYTPQENGVSERMNRTIEEMARSMLNDAGLPNTYWGDAVLHAVHILNSVPTRTLPDNLTPHEAYTGNKPSVAHLRVFGCKAYVHVPKEKRQKLDSKMFECTHLGFAANRKAYRLVHRATGRIVESRDVYFDEGTEVAPSRVTIDVTPTQEAPDARPQLPPSPRPPRPTVEDVSDEDEDTPALLDVDDSDDEDDDDNTDEDSDDDVPLPEIRCWRHAARTAQPPPPPPPAPELRRSGRTRTAPVAADDDRYFVSSYTRKPKGQDDVGGVGTDAAAADSENAEEVGDAENAHKATSWDEPQTYEEAMSRPDDACWKAACAEELHAFVKAELYDEVERSRNCKVIDCKWVFKIKRGPDGEIEKYKARLVAKGFTQVEGLDFNETFAPVAKFASVRTLLALAAKLNLEIHQMDVKSAFLNGDLDEEIYMKVPPGFRRSNSLVWKLNKALYGLKQAGREWYKKICAEFEALGFTRCHSDHSVFYKNDDGILLIIAIYVDDMLILSDNLTAVTTLKEDLKSRFEMTDLGEARWLLGMEITRDRPRRVLELSQHQYVEKCLAQHGMADCRPVSTPMAQNQKLVKLSEAEIDPKPYQSALGSLMYAMIGTRPDLAFTVGALSQHAATPGKEHWIALMRVYRYLRGTADKKLVYCGTTKEKEPLLGYVDADWAANVNDRRSVTGFVFLISEGAVSWSSKRQHSTAQSSTEAEYMAGAHGTKEAVWLRTFLSEIGQVQKGPTPLLIDNQSAIVLSKNAAFHERTKHIAVRYHFIREKYDSGEIEPEYVPTGNQVADVLTKGLPREKHEKFSAGMGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ63</accession>
    <name>A0A401GJ63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0405950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613125.1">
        <property type="nucleotide sequence ID" value="XM_027757324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ63"/>
    <dbReference type="STRING" id="139825.A0A401GJ63"/>
    <dbReference type="GeneID" id="38779129"/>
    <dbReference type="InParanoid" id="A0A401GJ63"/>
    <dbReference type="OrthoDB" id="3268967at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="173"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="506" mass="57725" checksum="B02259F5D96FF4F8" modified="2019-05-08" version="1">MVQYNLTIVYIRSEDNTVADALSRLPPSSFPDENDTPNETFNTWLTPSVNAVLTIATDSAVVKDITDRYLTDDFCKKVIANAPSTLGVHCSNGLWYIGDRLLIPCIKDLCENLFRMAHDCSGHFGADKSYALLRDLYYWPNMRHDLEQSYVPSCPDCQRNKSRTKKPSGPLHPLPVPDQHGDNIAMDFIGPLPADEGFNCILSITDRLHSDVHIIPTHMTLTASQLVLLFFDHWYCENGLPLDIVSNRNKLFMSEFWAALHKRIGILLKMSTAYHSQTDSVSEHMNKTINQAICYHVRHNQKGWVCALPRVRFDIMNSVNTSTGFSNFQLRLSRSPRLIPPLVPDHLELPSNHADFDTLQLISQLQSDVDEAKDNMLQAKIHQTHFANLSCGPEIKYHVGEKVMLLTLHRRREYKHKGEKCTAKFFPHFDGPYVITNAHPETSNYTLDMPNNPNKFATFHASELKPHIANDDWLFPHQLTMSQLWLAIPRTLGWLRTQARPVATRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ73</accession>
    <name>A0A401GJ73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD/NADP-dependent indole-3-acetaldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0405630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613096.1">
        <property type="nucleotide sequence ID" value="XM_027757295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ73"/>
    <dbReference type="STRING" id="139825.A0A401GJ73"/>
    <dbReference type="GeneID" id="38779100"/>
    <dbReference type="InParanoid" id="A0A401GJ73"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="110"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE82183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="300" mass="33249" checksum="55674CB352E4D7AF" modified="2019-05-08" version="1">MMRSWRAYTAVITCAVAGLTLLRQYSLTSPATSPVFPMSSLNLDIPLNDNNTIPWLAFGTGTALNGRDAEELVALAISNGILHLDGAQSYRNEESLGAGLAVSGKPRSSLFLDYVDLFLVHSPKNHEGELNSVWKQVEELQKEGLAKSIGVSNFRVQDFEEISKGASVVPAVNQIEYHPYVLKADQPVIEYMKKQNILPTSFGGLSPITRVKDGQLDPVLKPIRARVELTARETATDGQVLQLWLRAKGIPAITTSTKEERIKEYWAVQTLPRLTTEEVDAIDEAGSKAHHRFFSTWWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ99</accession>
    <name>A0A401GJ99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0406140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613144.1">
        <property type="nucleotide sequence ID" value="XM_027757343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ99"/>
    <dbReference type="STRING" id="139825.A0A401GJ99"/>
    <dbReference type="GeneID" id="38779148"/>
    <dbReference type="InParanoid" id="A0A401GJ99"/>
    <dbReference type="OrthoDB" id="3050970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="164" mass="18310" checksum="1CB989EA17D477F5" modified="2019-05-08" version="1">MTPLQPRTPTLSSHLGDTARLREVNGLALLPRPRTPLALCPFVLQFSHSPEEPPRGLRGDTAQLREVDGPTLAPPLHTPLALCPSISQIQRQDTIEIMSNIQYHYLDLVDAVVRQGSFIDKMYAFGWTEPGYFNAKEDELVLMHATARYHACVLPTLLRAKPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJR5</accession>
    <name>A0A401GJR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0407840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613313.1">
        <property type="nucleotide sequence ID" value="XM_027757512.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJR5"/>
    <dbReference type="GeneID" id="38779317"/>
    <dbReference type="InParanoid" id="A0A401GJR5"/>
    <dbReference type="OrthoDB" id="3230904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1296" mass="135574" checksum="8ACD23165AB4394E" modified="2019-05-08" version="1">MPSLASVRENRPERRRNRSGRVSRTSSVLGTLKNIVYSPLTWFGSAERLASQSVSSDDFEDTPGVNGTPAKRRRVVTAPLNGDREGSGRASKRKRYEEHPPPPQQVQEQAQTQQQQHQISHGYLDIPDRVVPPPPPAPRNLQPAQDRSSSIAIPPNFSQTQHTRHTDSPHASASYAAPSAIARTQSMDPPAMLNATRGSLRDVSMGSIPSGLPRDLTSSPTCAPFHVRMRTSLTPQPSGQRFGPMPSRRDRDASEPPPLAALMTNPVFVKTPQSVQQQQPQQPTLTLGSLGSHRGAGLGPYSPLFLGSEVASSAYYRPINAAEKALHDLDVYKTPLLPSRLRGSPKIPDMFRPKRFSVPTLLHKEQDNKPRLGMVDTGKGNEDLSSVSPYAGRGGLKKLLAKRRLEEEEEEEKERENAMEEDEDDSLQYEEPELAVPETLPPPVLLPAVPASPVPGRTQSSLRVGRTTTSRNHIQRPTRPVATNAATASTRTTGRYSAKFNEDELDIQMTTEATEEANVRKEVRKATEAEQTKEVQGRKEAQKIVLPPGFSFVNDKAPITHDATDAKEPPLTALPFSFADWAASKGIPVPTEAPKQPVSVFAKLASAPATALPTVAAESTPETLTVAPTTPALSTMPSFSLTPPTPAPPVPAPAPSAPSTSAQPARTEGSSIPNFFTNSALLKAGANVTQAVTVPPSPMFSSELAARPAVSALGEAKAAEPTAPTPTEQPKSTPTSLFGRPAPAAKEAPVQPSTSLFGSVPSAISATPDTLSGAPQKPAEEPKSLAPAFNFAAPSQAAEVSKPSGSVFSFATPPKPAEVPKHSTPSFGFPKPAETSAPSPFSFATTSKPAEAPATPAAPAQPSFFATPAKPAESSAPPSFPFTFGAPKAEQAKAPEAKAEPLKPSLFGNAPAAPSPFAGFGGAAASSPAAEQPKSAFSFTPSAPAVAAEQPKSFFDAAPSAGSAFGQPAASAPSDGTNAKSPFSFGASPSSTPAAKLAYTFGAPPSGGHGTDVSSKPFVFGSSTTSARPTTPPHTHDSEVMMDESPTRGSSMDMNGSAKPEIAKVQTGFTFGQSGTSGVSPFGQPNQNNSSSFNFASNPNPFGAKPEAKPEIKTTFAGFGQQAGSSGFTFGHKESTQSPLSPSPFPPSPFNQAPAQSAAAAFPFGGPSPGGAFGQRPSTAPSNPASPSTFNPPNAFNFAPSPTSAGAPANQFRFGSQPASPAAANPGLPQQQSAAPVQFHFAQTPVPSPSSPFPENPAQQPAIPGEVMFVMGSAPPPVPKENRPMRRLPNRRNAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJS0</accession>
    <name>A0A401GJS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0408020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613331.1">
        <property type="nucleotide sequence ID" value="XM_027757530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJS0"/>
    <dbReference type="STRING" id="139825.A0A401GJS0"/>
    <dbReference type="GeneID" id="38779335"/>
    <dbReference type="InParanoid" id="A0A401GJS0"/>
    <dbReference type="OrthoDB" id="2792843at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="163" mass="18695" checksum="1F50B21B65118D7D" modified="2019-05-08" version="1">METPEEELEWLSKDWKSVAYAFFKPEVTIESDASGKCVHVFHCMNRGCRMKISRWLDKGDAKSTGNLRKHIKACWGDEALTVTDEMKNADDARPCVAKFACSGSVTASFERKGKGKITYSTRQHTQQQFRAEIVHWVSESLHPFAIVEDRGFHSLMKMRCPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK57</accession>
    <name>A0A401GK57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0409270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613456.1">
        <property type="nucleotide sequence ID" value="XM_027757655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK57"/>
    <dbReference type="STRING" id="139825.A0A401GK57"/>
    <dbReference type="GeneID" id="38779460"/>
    <dbReference type="InParanoid" id="A0A401GK57"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15587">
        <property type="entry name" value="PHD_Yng1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000177">
        <property type="entry name" value="PHD finger protein ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="367"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="7">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE82543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="428" mass="47421" checksum="2C762576D04B2F22" modified="2019-05-08" version="1">MSYRKNRKRRRSQAFPEDEANVIEQLPVVEVAPEQEQEPRGPEDAVDAADATSDKEREVWDAFKEENYEVLEQLPLSLQRSFTLMLELDQQVHDYEAHILPSLRKYIELRTGLEGKFDAVQEQQQQNAGELAGASGEPDVEMSRPLPPPSTPGPSSGKSAVTTSPVTNATFSHLTRSSERPSTTRGLLTQVAQLSEEVVRASNEKVNVARFAYDLVDRYIRDLDRAIKEQETSISLGLRPGTHPASIILPDVVVPATRSIRITHSPSLEIDIESMHGVEPAETGGLNLGIPPPEHVAEAVAPPAPVRPRRRGKPKWSRKKSSKPTTENAADAEEPAASKKQTLTLTVPPLASVALDAVDMPVDPNEPRYCYCNQVSFGEMIACDNPGCKLEWFHLGCAGLTQAPEGNTKWYCRDCEKLIAPRRKTRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK86</accession>
    <name>A0A401GK86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0409430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613472.1">
        <property type="nucleotide sequence ID" value="XM_027757671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK86"/>
    <dbReference type="STRING" id="139825.A0A401GK86"/>
    <dbReference type="GeneID" id="38779476"/>
    <dbReference type="InParanoid" id="A0A401GK86"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="579"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="853"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE82559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1135" mass="123575" checksum="1E220F1E0446C565" modified="2019-05-08" version="1">MDFLFDCPAPVPCAPSLHSHSDTDTVYLSEYLWNALNLPQPADHRPAISVSRILPCRTNFSTSLSSLVCWASLDNNVTELAVPLRLLEQYGRVFWQSDFRPSATDRTHSVTVVRPVPLSEVILSALSSEAYAVAISNKSAVESWFFGKGMILRRGAICELVTEELGLSGRSACAYQLAMTAPVLQGYAKKGVTRFYISAHQLGGSMSNGQFSESPEVRSESDWNDLQKDGVEIDEDFLAGSVLHSMPGLSPRSNEGSPQPSSSRSSVEHDHPYGEKLHITMPEWTCTVEPLVQPVSPQWDDCTVYVRTSDLSKIAVLNGDWAVVRPRHGSSHRLVRVQVNEEQEETSTYVTAAPQLLYNILSKTASINDSEICLMSSPFGCRQPAIPMARAVTIARVASPFSTDRTYQYSFLRALQGYFKGTTRLVKQGDVITVKINTDDIQHQGEEDTSGEDGSDVGLESPCSSDNANEFIFFIVTNIEHNVMSNRGGATSPDLYVGSTVGELGCWVDPSVTRVIQTGVEHARVPDAALYLGISAENSPILMGSESLSSSLISPDGAFGKLLALTSAALNRNAVDYQLQLSILLQGPSGVGKYTVATWVTQRLGIHLYEVSCYDILGETPVKTEGTLRARFEKAASCSPCIFLLRHLDAFSQTTQSLEPGKEPTIVDALHECIAELQQSWNLTGFPVIVCATTSNPDRVSPRILSCFKHEVIFEAPGEAERYDILVSLLRTRTLAPDVALKDLAVQTAALVAADLVSFVSRAESASMKRAIQESNGCAEFDLVTAGIPLIAEDFDIALAESRASYSENIGAPKIPSVTWDDVGGLAHVKQDILDTIQLPLDHPELFADGLKKRSGILLYGPPGTGKTLLAKAVATSCTLNFFSVKGPELLNMYIGESEANVRRVFQRARDARPCVIFFDELDSVAPKRGSHGDSGGVMDRIVSQILAELDGLSTGKSGADVFVIGATNRPDLLDPALLRPGRFDRMLYLGVSTTHAAQVNILQALTRKFRLHPDLRLEGIAEQSPFHYTGADFYALCADALLKAMSRKAEELENTIAKLNASPPDTHHPYPLTPQYYLAELATPAETEVLVSEEDFTGALRELVPSVTQAEMEHYARIQQRFSKETINGAGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK97</accession>
    <name>A0A401GK97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0409750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613504.1">
        <property type="nucleotide sequence ID" value="XM_027757703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK97"/>
    <dbReference type="GeneID" id="38779508"/>
    <dbReference type="InParanoid" id="A0A401GK97"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019442016" evidence="2">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10007" checksum="3C521D3C53FB897A" modified="2019-05-08" version="1">MMCLLATALLNKLRGALAPAGGADDLTVHVNGFETALYFIRERQDRVTADVITVANALRQARVTIPTLGVKEHDSDVDSAPKGEAEDDDGDAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKU7</accession>
    <name>A0A401GKU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0411820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613710.1">
        <property type="nucleotide sequence ID" value="XM_027757909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKU7"/>
    <dbReference type="GeneID" id="38779714"/>
    <dbReference type="InParanoid" id="A0A401GKU7"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27099" checksum="CC9BB1C7497C43F6" modified="2019-05-08" version="1">MSEAAPKDSIFTLPGLRRFSQPILTRLSHGSAPFISTFVLIHLSAPVLANLGGSSLSSQVMILGREYYQTSFGEKFLLILPLLVHPLASAAKRLLAPRPARRLTSILSLTGYTALMVLPIHYFVHRSYPANPAPPIYALSPAELDYEYVKYALSEWPVRAWLGYVTLTACVAWHAAEGANVLWNTYVRGALGAFKARTPTARAVIAATLVLPVVSGLAVMAKEPVMAFTSQLARFHASFTQCFVYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKV3</accession>
    <name>A0A401GKV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0411590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613687.1">
        <property type="nucleotide sequence ID" value="XM_027757886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKV3"/>
    <dbReference type="FunCoup" id="A0A401GKV3">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKV3"/>
    <dbReference type="GeneID" id="38779691"/>
    <dbReference type="InParanoid" id="A0A401GKV3"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="835" mass="94485" checksum="5F3A9358508D26EA" modified="2019-05-08" version="1">MGDEYPSLFRSEPMSLVQLIVPTEVAHDTIAELGELGNLQFKDLNADVNPFQRSFVGEIRRVDEMARRVRFFASQIEKEKETIPIRPLYDSAPLLTVGPRAAQTMDELDNKLAEHEARLIQMNESYQILCDRTKELIEARETLRETAVFFEKALSYQSDVRASFDDSSAPLLQHDDREQQYSGTSVQFDLEFVAGVIERSRLPIFERVLWRVLRGNLYMNHTDIQEPFVDPATGEETRKNVFIIFAHGEVLLAKIRKVAESMGASLYPIDANTDKRSESMREVMARLEDLQVVLYNTGASRHAELVKIGESLASWQDVVRKEKMIYETLNLLNYDVRRKTLIAEGWCPTRDIPKIQLALRHATEESGTNVPPILHELRTNKTPPTYVHTNKFTEGFQTIMDAYGIATYQEVNPGLFAVITFPFLFAVMFGDIGHGFITFVAGLFMILFERRLAKGNLGEITSMFFFGRYIILMMGLFSMYTGLIYNDIFSKSLHLFSSGWSWPEQHGNESVVAVSNGHTYLFGLDPAWHGADNALLFLNSYKMKMSIVLGVIHMTFALCLQIPNHLRFKRVSDIWTNFVPQMLFLQSIFGYLVVCIIYKWTVDWSISPTGPPSLLNMLIGMVLSPGSVDPRTQLYRGQSTVQVILLMLAGICVPWLLIGKPYLQYKEMKKTQGQGYIGLGTDDMPRQATDTALEGEEEGNGRAIAESMEMEHEQHDFGEVIIHQVIHTIEFCLGCVSHTASYLRLWALSLAHAQLSEVLWTMTLGGVLGMSGILGYIAIAIMGSVWLTLTIFILCIMEGLSAFLHALRLHWVEANSKHYEAGGYTFAPLSFADEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLE6</accession>
    <name>A0A401GLE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613909.1">
        <property type="nucleotide sequence ID" value="XM_027758108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLE6"/>
    <dbReference type="GeneID" id="38779913"/>
    <dbReference type="InParanoid" id="A0A401GLE6"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23523" checksum="5C05D6AE28DEC382" modified="2019-05-08" version="1">MLLYSLSVTPEWQIMELIEPLLDMHQLEHLDISVRDPVSVTDKDVRDMVSSWPKMKSLQLRMYEGSRVPSLSSLVEVARCCPLLEVLQLPPVKTDDVVELLGELPSISNPNLKELSFSGPYDEESEVEEVELRPQDPVRVTEYLLRLFPNAKLEWDGSMPGAETSSVDGTDPAPDNDSRNADSSLGNEDGDDDAYSESENGLGSETSDGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLJ1</accession>
    <name>A0A401GLJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0500320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613902.1">
        <property type="nucleotide sequence ID" value="XM_027758101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLJ1"/>
    <dbReference type="GeneID" id="38779906"/>
    <dbReference type="InParanoid" id="A0A401GLJ1"/>
    <dbReference type="OrthoDB" id="3466517at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="365" mass="40479" checksum="24BCCE2164CFAA13" modified="2019-05-08" version="1">MPVGPVDDKGTALYYEDSGVPGASTTYATIFLVHGTMFHSGIFRPMVPYAAVHNLRLVLVNLRDYPGSSPYSPTERELLAGPGREAQAAAIQNRGLELAAFITWFIEQEQIPPTSRSAAEAADTTGGFALLGWSSANCQTIPVIAHADKMPEKTRKLFNAYFRAYFFHDSSLTGIGEAAPQDMYGIFRDARLTYEEKVAGFPAWVSSYFTRVDLEPETPAFLSTLTSRKAVHEDTDDARWTPSVLRMSDDVFAAVADPSVMLRSQVLIQNVDVTVYGENLRRALSRCYIDGDNGREEIWPSLKLRALWCDMSVGEELLAASKIMGILDGISPAGRNLEFVRVENANHFVHWDQPETFVRLLANEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMA0</accession>
    <name>A0A401GMA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0503730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614238.1">
        <property type="nucleotide sequence ID" value="XM_027758437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMA0"/>
    <dbReference type="GeneID" id="38780242"/>
    <dbReference type="InParanoid" id="A0A401GMA0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="151" mass="16382" checksum="E56178E5E8E13203" modified="2019-05-08" version="1">MHALCTARVSTDQARRERTSTEGGALSGRTGAPRPIRDQEQGRVSCGLGREGIPTERGRGRRADSAGTGAESSGGADGGERGARGRPDTLGLQSGDLDGCGDQNEARWPFRGTVPRPAEWRVERHGSELVIKARMREIGYREMWDARPVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMZ2</accession>
    <name>A0A401GMZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0506430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614501.1">
        <property type="nucleotide sequence ID" value="XM_027758700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMZ2"/>
    <dbReference type="STRING" id="139825.A0A401GMZ2"/>
    <dbReference type="GeneID" id="38780505"/>
    <dbReference type="InParanoid" id="A0A401GMZ2"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="345"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="630"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="985" mass="107601" checksum="55FB5E78FF7AAF5E" modified="2019-05-08" version="1">MDRGRGVERGRGRGAGGAGRGSPTGRGSPGDRGRGAPGDRGRGGGGGYRGGGDRGGYQDRGGFRGGDREFFRGGDRGRGARGGFGGPPAGVFNPTPNAPAVVDARLTDNSQEQLIASFRTLRLQDTDLPTRPGFGTLGIPIKLRTNFFPVKVPKGPLFEYDVSIAPGVTIRRVKRRIFQLAEQLPDWIQAGMQGRVAHDFSSKLISIAKLPQPLTMKILFTDEDEDEQQNRPSKEYTLTFKYIQDIETQSLVSYLNGDKQYRQYDIMPVISALNLVLAAHPNRSTGGGVMVGRNKFFHFSQQFPPFPLGGALEAYRGFYSSVRPAHKQLMVNVNVCTTAFYVPGNLAERMQEFEAASFGARASAFVRGVRVKTTHLGYTKTVKKLATVNANQHRFNAEGFGEVTVAQYFQKKYRISLRFPNLPLVDVGGQKSNLLPSECCVILEKQTFRGRLSDDHTAAMIRIACQPPNVNARDITGRGLTELGFAAGPDPLAAFGISVGREMAVVPGRILPSPTIRYGEGTPRIDDRASWNLRDVKFASGAVLDKWAVLLVRDGNGGDQFNGPNDPELHRTVAGFAAMCTKSGMRVEAVPPHMYTAVNLPQKDSSDPVRGRAVGAIRDTLRALKSKPKLILVVLSNGDRSVYAGLKHLCDVYLGVATVCVHAAKIRKDRGQPQYFANVALKVNMKMGGVNHALDQRNSNMVWLRQAPTMLVGMDVTHPGFGTVKGTPSIAAVVASTENNFGQFPASMRIQESKKEMITDLAGMMIERIEAFQNSNRNVLPERIVVYRDGVSEGQFSIVVDEEMPEIKKAFTKFSTPKKQYTPKLTIVICGKRHHTRFFPTDAQNAAADGNPKPGTVVDRGITAVYEFDFFLQAHGGLQGTTKPTHYYVVHDEIGFSADQLQGLTNDVSFMFARATKAVSLVSPAYYADLACERGRCYIHSLLQGISPSGTTASSGTAEEDAMRKARSDWQNGVHSVLKETMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN67</accession>
    <name>A0A401GN67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614555.1">
        <property type="nucleotide sequence ID" value="XM_027758754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN67"/>
    <dbReference type="STRING" id="139825.A0A401GN67"/>
    <dbReference type="GeneID" id="38780559"/>
    <dbReference type="InParanoid" id="A0A401GN67"/>
    <dbReference type="OrthoDB" id="2798624at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="767" mass="82103" checksum="3CCFF59C861B030E" modified="2019-05-08" version="1">MLPPVPMATLASRPVSTSCIDELTLHEPPTDVFAPFVTAIPLSFLTSHHNLRSSAESQPIVPHLPSPYPLPNTRADPKPDRAVLVALAERNRELDTALQRQYQVNKRVPALETALCAERAALRTARDTIAELAASVAALQADLAHSQSLLNRQLDNDHARVLAAENTALTTERLRHRKFIELMIAIGGHKPVLDRAYRDLSAGTDPEAALVTAIKEATARPDSVWATLLEPLIGTRTPEEYLAQVQCTLRARKELRDWRKRAKFWKRAAREADAHAATVTPSPSDVSSVVEVLPPARQEAVNTLLEGVRNGTQPLRVNKRSKTTEFAVSPAALPTTSSAASVPPLSVMTTRPSSTVLPASQTSSTVRPSTSSSSAYANLAPLASETFRASHSIPSVTSRRSSIALPFTISPSFPRSLSGSTGFGFGSMFGLNAGAGVELKARRESITPSASASTQASTASTRSRRRRAHLIALEQAQEGSEQPAEEAPLTTADPVVPEEPEPVNGTESIVNESASMDERPETPTVSASDSSSRPSCTTPTAAAPAPSTPSKEPTSCDHTGEVPSSSATPSSLGSSSANSLSPSPQRKDSVLKSSDLDEAQFDDSDELVMVMHSDLLETNTPEAFSRSPSPRERQTPSPEKRSRLPVPVLRNLKAIRRLSISRPVLVNTTNAATFTFSTKAAVAKMTTKRAKAGADRKGMRVRDENNEGSPRGKGVRGGDRTQAAVPAGSPSRPSKIPMGQRIQQLHGDFVGSARRVVQAKTRTNRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GND5</accession>
    <name>A0A401GND5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">PSS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0503020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614167.1">
        <property type="nucleotide sequence ID" value="XM_027758366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GND5"/>
    <dbReference type="STRING" id="139825.A0A401GND5"/>
    <dbReference type="GeneID" id="38780171"/>
    <dbReference type="InParanoid" id="A0A401GND5"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE83254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="443" mass="50961" checksum="F993BDF8FC0BA829" modified="2019-05-08" version="1">MSDEKDSARPTGSPTEEPDAPAVEKAEPKPGLNGVPVRWFDADRTEPYTRITPFQEMHDTSVEFFYKPITLTALSVGLTVLAYVATTQDVLQEGKDKRRVGAYAVIASFLLFSMIQFRDGPFVRPHPAFWRIVLGVNLLYEMALVFLLFQDLDSAREMLVYLDPSLGRPLPEKNYAENCAFTPLNVWNALDIFCVAHALGWFGKALILRDYWFCWILSIAFELAEYSLQHQLPNFAECWWDHWILDVLICNWLGTYLGMKTCQYFEVKHYTWRGLRQTHGLRSKTQRVISQFSPHDWTTFKWEGTASFGHYFAVVVLLAVFLAAELNPFYLKTLLWMEPDHPFVIARLAGVFLCALPAVRELYQYVNDPRKAVRMGQHVWLLLATIGTELLAITKWSQGQFPDPLPTSVKWAWSIGAFLLVLYPTVQFGIPSLRECKKRRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNE4</accession>
    <name>A0A401GNE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WC-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0507910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614648.1">
        <property type="nucleotide sequence ID" value="XM_027758847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNE4"/>
    <dbReference type="STRING" id="139825.A0A401GNE4"/>
    <dbReference type="GeneID" id="38780652"/>
    <dbReference type="InParanoid" id="A0A401GNE4"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="447"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="607"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="794"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="872" mass="94410" checksum="A36552B4EECD3044" modified="2019-05-08" version="1">MPFERYLQAPSSSSQHRRSYDNYPVAHPDPSFGIDASTFSSNVQFQVPRMMNPAPTLAPGGGAEVLPPGLLPSSGPISSWFPAAGYRSPDDSSPSCSASPVYRSHPSLTAPAYSLPPDPHSYRHPDFTDSPVNSPPGSIPSSSSAPYAFPLQNPPPADILISPDSHIHLDAQLLLRAHLSIPSSSLPLSIPSAMGLPVYSASGFDFLSILSRVANRPHPKVLLGPVDLTCSFVVVDVRRYDSPIVYASPTFFKLTGYDEHEVLGRNCRFLQSPDGRLQRGEQRLHTAPEAVGLLKRCLVADKECQTSITNYKKGGAAFINLVTVIPIPGGVNNAPAEADDVAYHVGFQIDLTEQPNAILEKLRDGSYIVDYSRKPHAPPLLGNPSGSRNWRSNSISMSGVSTELRTLLADPAFLQSISVTTSTTASCPPSGEKLDVYDGNKPLHMFLLECAPDFIHVVSLKGAFLYVAPAVRSVLGYAPDDLVGRAVSDFCHPADVVPLMRELKESSITPGPGSSHLIAAPSDAGPRNVDLLFRMRAQSGHFVWVECRGRLHVEPGKGRKAIILSGRLRSMPRLDWDPVDRAGGLAASARSPGDDSRKEREHEFWALLSTNGTCLFVGAAVHDVLGWGAGEVIGRALGDFIGGATTADARRALEDELARALSPALPRPEVHHRGVSCEMMRKDGVQVVVHITLFRSQDNSDVLAPDDAWQGAVAVPHAPPCPVVCQVKLFDAPSDGPPAAAAGGILHPLTDSVFDELHIARGSSWQYELQQLKFANQRIKEEVAALEASLCSKTRQRPFSQSTSRANPAHEQQQQQSQQQQQREQYAHHPELLPDNTNNWSTPYVQYPVNLAPLQPSQTLKRSWHAIDGAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNX5</accession>
    <name>A0A401GNX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614836.1">
        <property type="nucleotide sequence ID" value="XM_027759035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNX5"/>
    <dbReference type="GeneID" id="38780840"/>
    <dbReference type="InParanoid" id="A0A401GNX5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="84" mass="9530" checksum="EC7CB0A53A5A6363" modified="2019-05-08" version="1">MTHSSGWRGKLNSQIPGFQRQLQEPPRHIDRTQAQMKSLGEGNLAYHSVIFCCPCPTKYPAFLPPHCHRSLLNECQLQLLRACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNZ3</accession>
    <name>A0A401GNZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">eIF-2-alpha kinase activator GCN1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0510020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614856.1">
        <property type="nucleotide sequence ID" value="XM_027759055.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GNZ3">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNZ3"/>
    <dbReference type="GeneID" id="38780860"/>
    <dbReference type="InParanoid" id="A0A401GNZ3"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1397"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1572"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="1690"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="2037"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2556"/>
            <end position="2581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2581" mass="283317" checksum="8701048F758A978D" modified="2019-05-08" version="1">MGKHEIESWIASTSTASDDLDSSNASGLQEWRRDYVLTDWPKALDVARTRLFTSSTKVRLQFLREELLVLSKYGDFSLSQTMDVFKLLTQTYTRYIDAPSREAVEAVGSELVRRDELRGTPDGEPESTKLGVTEQIFGWLSHEVGLISKRASSHAAADMFVLLSWCCGLYVTCLKANPNFAGTYAWDKMINVFAMLVDMLLDKSTRVKKSIQKSALVRTRRALRSCPQYLRDVMNTLLALAKTSTSPLFVVPLLGLSVDVTLHLKNLKDEQLKKVDPTIKEDILAFYVSSVLMSRSPVTSHTSTALHDFVRTQVTEDDFTTLVLPTMEKALLRSPEISIGVISEFVAAYSHAIEGDTFRRLLTPTLNNARSTNTIVRNNATVLFKVLLERTPSPSDMELALNEVLSLPKAGKTAGPDHRLALYTMLAYVKPSTSISSTVVQSVLPLLAKETHDAAVLVLVASVTPHLVFCLRQNIAFPSEVTALVTKEMTNAKPVIRRAFSTLVGDTFWQLSKLDSEASLMFARAVLPAFETNLRSIASNPLNSIVGSLEGYAALAILLGPFAHSGKFEDFIAHSATIQSLIATGSKPSFLLWDKVYHRLNAVEDETWLLRASEASLSFFKDELIQNEHACAMMGMIFLHLAIESHTPQIRRLVLTSLETLTANNPEVVNCVITAALTVYLSRPSTHKFPNDAGDEPNSPVNREGRLPAVLLASCGFADRCDQTIRQNSLVNLVVLAHHPLLCVHSRQTWIELCQKAHVDPHALVCARLDDILKKVMNALDSHAKTYHDVFAEAGYRAVTTLAFVSPQEVLPRIIEQIRADINPEEINSLSEMDLGVWSVPEGKTYVDVLALKDIDVPVKKGKGYKEAQWEAEVRKSLASKKGNAPATLSKQDQALVHAQLEKESQIRTRVAVIKTKFDRGLNLVSSIINAHVDEFRPYLSSVATLLLKGAFGNGVALVGFNAFDRYLALSNTCSDRLDTLRTWIGVATLRSLGINEIPEDYTVEPLNSLVLRVLYRLRSLSEQSPFDAATFSYSSPLLSEVLLKGGIALTDEDDPLEQVALALGVVRFHCGEFSEPTFPRIQTMENLIHVIRTQPKLAKEASSALIDLGEAMNPTATREEISALLRGTLLQEVYVRNSCLQTLQPFDLTDFDWSPEIWIASHDTDEQNARLARRVWEDNGLDVPESFVVDLSKFLEHDNAYVRSSAAVALADAVIDIWPQSITNVLAILKDFYREKAKVLAPEYDQYGMVIAQSLDRSDPWQARVAIARSFELLSPAFTAEDVDPFFKFLILDEALGDRYADVRRGMLSAGTAVIDLHGLAHLAELIAMFESHLSATGSSTETADFIKEAVVILFGRVARHLEPTDKRVPQIIERLVDALKTPSEQVQIAVSDCLSPLVQVMQLPAAELIDRLLNELFNAPKYAVRRGAAYGLAGAVKGAGISAMKEYNIVERLKAASEDKKRYEPRQGAMFAFETFSSTLGRLFEPYVTHILPVLLTSFGDTVPDVRDATHDAARVIMANMSGYGVKTILPSLLSGLDEKQWRTKKGSIELLGMMAYCAPKQLSQSLPIVIPRLTGVLTDSHAQVRTAANKSLKQFGEVISNPEIQSLVPVFLKALVDPGKTPNALSALLKTSFMHYIDHSSLALVVPIIERGLRERGADTKKKAAQIVGNLASLTESKDFVPYLSRLLPLVHVVLVDPVPEARATAAKALGTLVERLGEIHFPDLVPGLLRTLKTDTSGVDRQGAAQGLSEVLSGLGMERMEGLLPDIIANAQSPRSTVREGFMSLLVYLPATFGTRFQPHLPKIISPILSGLSDSEDYVRDAAMRAGRMVVTNYSTKAIDLLLPELERGMFDSGWRIRQSSITLVGELLFKVSGISGKSEVEGDEEIGDTATAESSRRALVEVLGVERRDRILSALYLARQDAVNVVRQSSIHIWKALVHNTPRTVRELLPELMNQIILLLSSSEVDQQETAARTISELCRKSGEKILGEIVSILKSKSISTDPQTREGVCLALCEIMESTTDNQREGHEDDMIAMVRAALVDDEANVRSAAAKAFDTLQEQIGAKAIDQTIPTLLEALRQPGQSSGTALQALKEVMAVRAATVFPVLIPTLTTIPMSVFNARALASLVTVAGTALSKRLTVILTALVKMIESSEIERDEELKTAVDEATRALLASVCDLEGLNTLMLLLLGWAKHDSIQRRVSGCNLFALFCEESQLDSSLYRADWIRQLVSLLDDSQVAVHSAAWRAFDVFVKSVPKDELEPLVVPLRRTIESTGAPGRHVPGFSLPKGVSPTVPIIIAGLTTGSNEQREQAAYAIGDLVERTQESAIKPFVVPFTGPLIRVATQASTYPPAVKTAILSTLSTMLEHIPLFVKPFFPQLQRTFVKSVSDPASLVVRTKAAQALGMLMRSQTRVDPVITELITGVKSNDDGIAGSLMFALAQVVHSAGSNVGEKAREACADLVSESFRESHDEYYIQSVASLFAALSAYPDLVKPVVEAYLTAGTPASVLSSHCILAVLSPDEDFHQSQDTTVFQTLGVLRSVRQKVQESIASEKPSISRPAREASSLLKSIDDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP24</accession>
    <name>A0A401GP24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0510340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614888.1">
        <property type="nucleotide sequence ID" value="XM_027759087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP24"/>
    <dbReference type="STRING" id="139825.A0A401GP24"/>
    <dbReference type="GeneID" id="38780892"/>
    <dbReference type="InParanoid" id="A0A401GP24"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="61"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="283" mass="32246" checksum="8C9B2F75C7AC3B47" modified="2019-05-08" version="1">MTLSIVYRIMSLMVSFLPVRFRAKLWTYLMHVGVRQWPRESAAQRIPGGMYVKASSLIRLSEGQVLRYVGAHTSLPVPVVVDNFTFGRNTFLVMSRLTGQPLSEVYVDITPEVEGLLSAQLSRILAPLRALPPPSDAVCGWDNGPVHCERVAFGSPPVGPWESVAAFHHELMARTRRLVVPEEKTEVVHDVVQRAHSRTHRVCLTRNDLGPHNVLVDASWKITGIIDWEACAWMPEYWELTKGTFLPQCRKGRWNRIMTAVFPMYALELEAERYIVNYRECYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ02</accession>
    <name>A0A401GQ02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0602930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615228.1">
        <property type="nucleotide sequence ID" value="XM_027759427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ02"/>
    <dbReference type="GeneID" id="38781232"/>
    <dbReference type="InParanoid" id="A0A401GQ02"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="344" mass="38363" checksum="079B89783B8BA3BD" modified="2019-05-08" version="1">MNASIILHKYTLAEALLRIEIFTEPFDSILWKAWAVRMHVLLVLMVQAQSEAASVGIILPLPHDIPVLAQVEIHLATAHTVEGGRQMIPQIADHLPAVIPHGLTARVLYDDPAVREDFGLGHPPDGLPDIGILRLRVETLRNAARELYDVMCGITGRRELADEYDLRDAMAQVQGHLTKGDRSAQNQVQQVWTHALSELVGVLEARFKTLTDFGELDFDPRKIDAIRTAFVDVIVHARVQSFPSALLLEPSQDEINAAMERLVLGRDYFTEVEHHRRGGLRVWHLRARILHQMSGMEVQVHVCEAEGEIPRCIQADISWITLSLIPPPLAMSTHTAGSPGPQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQJ3</accession>
    <name>A0A401GQJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0604080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615342.1">
        <property type="nucleotide sequence ID" value="XM_027759541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQJ3"/>
    <dbReference type="GeneID" id="38781346"/>
    <dbReference type="InParanoid" id="A0A401GQJ3"/>
    <dbReference type="OrthoDB" id="2786563at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38668" checksum="D970D05082BB2277" modified="2019-05-08" version="1">MHGAISSIPEELLEHILEHVVTPSVHCSTTRPPWHMTRPAPTLSADVPSPDASRHTHIAALLVSHTWIRIATPLHYRHVVLRSARHTSLLASTLRANPDFGHWVRSICVEGVFDGLEDVVAMCPCLEEFDMTIDDGAVSTATIPGGAPGPDVKVMNEKLLHFCASFKKMTSLKHLTIRKTAYAYLTLPRTTLLFEKLSEAIAEWKHLKTVDIAFRFSPPASLTQFTAALIAAPALRTVCTVLPSVWNSALLEICLNPGLERIELSSDIKITDTHLYLNEARKHTRLFDLIRTGTPLVRPRAHTMTAPRAPAAGPAPSVDVQTAQAEKPDAGTASVTDNALLVRTAPGVRRMSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRA6</accession>
    <name>A0A401GRA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0607320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615665.1">
        <property type="nucleotide sequence ID" value="XM_027759864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRA6"/>
    <dbReference type="GeneID" id="38781669"/>
    <dbReference type="InParanoid" id="A0A401GRA6"/>
    <dbReference type="OrthoDB" id="2803471at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="70"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="343" mass="37704" checksum="78051EDBC2CE1439" modified="2019-05-08" version="1">MPALAHASLSRRPMHRLGEHLGQAFAEATVLTALSNPFLMVSVRHCSPTIHAVMALALYQQDFRAAAGYASAFVVIFYDYGLTFAREVHTMWGAKRKYTFATILFYIVRYAGLLFVILVMRSTWSTKSHLMALNILLMAAVAVFSAMRVYALYFGNYFVFGIVLLLGLTNPILTMYISIMTEPQVAVLSPTLNSCGMMPKIAPGPFEKLFMGTRACSIVADAVVVILTWMKTLHYRRAAMRANARMSVTTVLFKDGTAFFSSLLFLNVFALGIGQIADLIVVMTTWTTVVTSILTCRFMLDLREATSSSDPSGLSQTIPLSAMPVGIAFVEASKDVGEDTYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRM3</accession>
    <name>A0A401GRM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0603530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615287.1">
        <property type="nucleotide sequence ID" value="XM_027759486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRM3"/>
    <dbReference type="GeneID" id="38781291"/>
    <dbReference type="InParanoid" id="A0A401GRM3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="172" mass="19697" checksum="ECAE80367F1DEFAD" modified="2019-05-08" version="1">MPATSLDDSKCISWKPGELSILDEKHAEYQVFKLGSVQRKELLDVMAEALQKASPRLQNMQLLTVRKKVLHFFKNDRVRKIQGDGRVPPNTRMLFSMCIRHDGASALWVNSEERWKASLFKKLPAEEQKEWAEKADVLRKEEENMSLDEAIAVNQETLFVTVAMGLKALIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRV2</accession>
    <name>A0A401GRV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0701440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615875.1">
        <property type="nucleotide sequence ID" value="XM_027760074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRV2"/>
    <dbReference type="FunCoup" id="A0A401GRV2">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRV2"/>
    <dbReference type="GeneID" id="38781879"/>
    <dbReference type="InParanoid" id="A0A401GRV2"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="596"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="788"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="865"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="972"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="878"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1112" mass="122081" checksum="14FE3053CD7F616E" modified="2019-05-08" version="1">MYPISDLTAFCRRTTGDVPPKLVGASTTVVGSKMYLYGGRLVQERRMVSDIYMFDLESFNWERLVQDPEDDIPQARYFHSADTWNNHLIIFGGMAIKPQSDNPEDLCVLNDVRLFDLSSGHWLPSPSTVGDPTFVPNARYAHLSSVTGDRLFIIGGQDLANVWLDDVYIYDLVAKSWVQRRDYSRHCGTYRSVAVTADMRVRLPQEEMQAGESLSSKLGPPGARFKTNKTPSSTAPITQPDSLIHLPYSASPTDDYPCDIFLFSNYNFTDVQRELEVFTPLPDYDFAVSDRSAAMSGTYFPPGLRFPTGAILGTFFIVAGTYLSQQYQSFSIWALDLINMNWSRIDPGSALASGSWFRGCLWPAMNKFMVFGNRHGSIVEDYNRRLLSWDHVTCIDLEAFGIYQPPALRLEIPMQELGLAALEEGVLTDFEIVCDDDRRIACSRKMLEDRWPWFKEQRKLFAIAATQTTEMMPSIAQHVPVPDLRGISDKEELRPDPRLTPRAFHLSEPYPVTLALVQYFYTTALITPVQHAPAVLSQLLLLSSTYQLPHLQDLVKHAMHRALSYATSVGIYGVSTLCNCRSLQIRALRVVMAYSQKRPTGGRSRSDREGGSGDRHHDSNNGGDRHGPKGGGPPENSAARPRGLSDASYLRGPSDGRGGNSGQGYMNGFKTQKLPAKASDPVPLITGRPRAMSEVVAPRSCRSRSWGPSRPGHSTDTSLSDTSTVYPGQGVGPPSSAEASTSRGEKTSYSSRPFSMISLSTDEELRAVAEIMSPVIAPSDLVTGAQDVDSRSVASSSMASDARSNKRSSYRTSSDSLSLSTSSCTPSTSYVCSPTDAESDGHYSGFGDSALLSPTLGTHIAFHLPRTPRRMSQRDSDTPSLSSSVSFSSLSTPSLSRTSSFHRSPPISPTSSMSPLFVPPTAPARPSHLDAIQENRVPEDEGVPPDSDDPFVRTGIVSSPMVSQDELGHEIVATDSDGPSWNHNEDSISEYPNLPPTACVSETSLESHPTMHQSSLVHGAGALTRLFSRSDKDAKNKAKGKHSLYQEFSASALSLSLAKAEEKRTKKEAVRRRAETLALERYREKHSSKQPTVEDVLIMNSGMFGGGFAMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSK1</accession>
    <name>A0A401GSK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S19-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0703940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616121.1">
        <property type="nucleotide sequence ID" value="XM_027760320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSK1"/>
    <dbReference type="FunCoup" id="A0A401GSK1">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSK1"/>
    <dbReference type="GeneID" id="38782125"/>
    <dbReference type="InParanoid" id="A0A401GSK1"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="18011" checksum="EEB6362AF67215B5" modified="2019-05-08" version="1">MPGVRDISAEAFITAYASHLKRSGKLEVPTWVDIVKTGSFKELAPYDPDWYYVRAAAVARHIYLRKDVGIGALTKLHGGRNRRGNRPSHHADGSASVQRKVCQSLEKIGVLEQSDNGGRRISQDGQRDLDRIATAVVEAARDEGEEEEEEEEHAAAEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSL4</accession>
    <name>A0A401GSL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0703460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616073.1">
        <property type="nucleotide sequence ID" value="XM_027760272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSL4"/>
    <dbReference type="GeneID" id="38782077"/>
    <dbReference type="InParanoid" id="A0A401GSL4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12155" checksum="9DC6CA921088DA33" modified="2019-05-08" version="1">MTDHGRTISLAGYGGTRSPTLRPRHRRVPAALRPHSRHPADGQQEPRVPGNAFPSGVSAAASSASYSGSIMQTSADLVAAIENPVAPSGERGGTTQPVTIALVVVVSIMGVDKIFAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTF1</accession>
    <name>A0A401GTF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0706460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616372.1">
        <property type="nucleotide sequence ID" value="XM_027760571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTF1"/>
    <dbReference type="GeneID" id="38782376"/>
    <dbReference type="InParanoid" id="A0A401GTF1"/>
    <dbReference type="OrthoDB" id="3250756at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="355" mass="40911" checksum="BD22FF075889CA6C" modified="2019-05-08" version="1">MTALPAELCNQIVHYSSQRDLFSLCLTSKALQRATEARIYECIFLRDMGVAYRACRAIVGRGGVRGAYVKRFWFSQDTRRLPPRTMVQLPPQFWQAVQDALTKMVNLDFLLLNDPANANTWVLSSPTYKFQLREASFQLPWDAEMVAFLQTQNRLRVLHTEDSFEDGPLPAITPGKLQSLQVYNGPVLVVAELMACPLTHLQIMLEEDTAVLLGTVVTDLGRSMKTLRSLNVAFMPEHYMLETLQLISTSVFAPTLRHLGILPIPYDDRSEVHRCLMRLPALHVLEVDVFNWEPQPVEVFQRMLASELRIYCPSLRYVSFWVGQHHLIWHCVDEEWTSCHFSPRHPQNETLWRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTL7</accession>
    <name>A0A401GTL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0800850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616481.1">
        <property type="nucleotide sequence ID" value="XM_027760680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTL7"/>
    <dbReference type="GeneID" id="38782485"/>
    <dbReference type="InParanoid" id="A0A401GTL7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="10907" checksum="DE9F1F61049BD3ED" modified="2019-05-08" version="1">MGRDGASERDEIRWLALGRGAALEADADETASAKPTPSFASVTSPSHPSARSRSRPRSVRALPPIYPRLTIRLRPATNSDTFDASALAVLHPLSSSTRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTS9</accession>
    <name>A0A401GTS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616496.1">
        <property type="nucleotide sequence ID" value="XM_027760695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTS9"/>
    <dbReference type="GeneID" id="38782500"/>
    <dbReference type="InParanoid" id="A0A401GTS9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="158" mass="17638" checksum="0731C41D0AF55A95" modified="2019-05-08" version="1">MSVPASPTLVNGVPSRAQTPFIRTSSPSPSIELSHASDEQEFATRLVSAIRVPVDFTDILVALRNRPQDRQAVVSMQRALEMVEWMQTARQELVAAEERTSRARTRVDQVWSLMRSTVTRTAQEIWREHGDEDIDILGYTTNGIPASTPRSSPEPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTZ1</accession>
    <name>A0A401GTZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0801690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616562.1">
        <property type="nucleotide sequence ID" value="XM_027760761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTZ1"/>
    <dbReference type="FunCoup" id="A0A401GTZ1">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTZ1"/>
    <dbReference type="GeneID" id="38782566"/>
    <dbReference type="InParanoid" id="A0A401GTZ1"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="280"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="3">
        <location>
            <begin position="592"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="775" mass="84347" checksum="4EEADE0EAB0F09D8" modified="2019-05-08" version="1">MSSGGATTKASSIPDKSIRICADRGGTFCDLHASYPDPENPHERKELVVKLLSQDPGNYGDAPTEGIRRILEVVTGDHIPRGSVLNTDKIDYIRLSTTVATNALLERKGHKHALLITRGFKDLLLIGNQARPKIFDLNIRRPPPLYSTVVEVDERVTLVGYTSDPQAEQHAVQFDEQGKVKRGYRGAGWDGQGDAEGPGEIVQGLSGEAVRIMKKPDLGAVEKDLRRLYDEGYRSLAIVLCHSYTFPDHEVAIGKLARRIGFEHVSESAQLLPMIKLVPRGVSSTADAYLTPILRQYLDGFFSGFDEKLKDGRLRSPRVEFMGSDGGLVDLNNFSGLKSILSGPAGGVVGYALTSWDEKKKLPIIGLDVGGTSTDVSRFDGRYEVVYETTTAGVTIQSPQLDINTVAAGGGSCLTFRNGLFMAGPHSAGAEPGPACYRKGGPLAVTDANLVLGRLVPDYFPKIFGKSEKEPLDVEASRSAFEALAKVINESQEKKYELDEIVNGFIKVANETMCRPIRALTEARGYATSKHILASFGGAGGQHACEIAHLLGIKTILIHRYSSILSAYGLALADRAFELQEPSSTFYTADNRASLVARLDKLDAGVRKELARQGFEGKHVHTERMLNMRFEGTDTALMVLPSAKDGDGKEDFEAAFKRVYLAEFGFLLETKTIVVDDVKVRGIGKTFDSLGESVYSEVARLQRRTVGRSKADSTYSVYFDEVGRVPDTPVYLLPTLAVGDAIEGPAMIIDNTQTIVLIPGAKAVLTSKHLYITLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUS4</accession>
    <name>A0A401GUS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616865.1">
        <property type="nucleotide sequence ID" value="XM_027761064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUS4"/>
    <dbReference type="STRING" id="139825.A0A401GUS4"/>
    <dbReference type="GeneID" id="38782869"/>
    <dbReference type="InParanoid" id="A0A401GUS4"/>
    <dbReference type="OrthoDB" id="2659442at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="84" mass="9684" checksum="554BA08AF106DCE3" modified="2019-05-08" version="1">MEHSKEDGTLPPIAPQLLVDMHISRAEEAFMEIDEQVTEEWRLKNEIPNTDVIEETREGLAQKRNRAPSTVVKQPRRKAARYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVB2</accession>
    <name>A0A401GVB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617049.1">
        <property type="nucleotide sequence ID" value="XM_027761248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVB2"/>
    <dbReference type="GeneID" id="38783053"/>
    <dbReference type="InParanoid" id="A0A401GVB2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="7639" checksum="28E687A5B0D9ADA0" modified="2019-05-08" version="1">MKAIAPSPFALNLMGQTKLNPSYGVASVVSRFSPAPTLCLFPHQRRSLPPGAGGQPAPLCAPLPCPHFGLAACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVD6</accession>
    <name>A0A401GVD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0900260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617062.1">
        <property type="nucleotide sequence ID" value="XM_027761261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVD6"/>
    <dbReference type="STRING" id="139825.A0A401GVD6"/>
    <dbReference type="GeneID" id="38783066"/>
    <dbReference type="InParanoid" id="A0A401GVD6"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="34663" checksum="C47C520B6CEC525F" modified="2019-05-08" version="1">MQRCLRRLYSAIPDAAATARTASTPLAVRRRRLRKQPAVGTNESDATPDGLTPTEFARYQRALAKGELMGEDGLSPTEAEWLEKLNGRRSRMRGVRQLLNEDGEKEVRVVGQKIYLPNIIFRLVRNHTPAGQPYNPYEATFRISQSVTKTDVRSYLQAVYGVKTTYIRTDNYLSPYTRDPADFSFSVKKVYKTYKRAVVGLVEPFYYPQAKEDMNAADREKREKWLEENFGMKLLEDARTLELLRRTRGSGSKFRWRTGVTAQRGNILRIISQRRAARELAIADTKERMRESRQTAEAVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVH5</accession>
    <name>A0A401GVH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617119.1">
        <property type="nucleotide sequence ID" value="XM_027761318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVH5"/>
    <dbReference type="GeneID" id="38783123"/>
    <dbReference type="InParanoid" id="A0A401GVH5"/>
    <dbReference type="OrthoDB" id="2756970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="305" mass="35861" checksum="0F8DA84154ADF9CC" modified="2019-05-08" version="1">MAEPLESQTNVLIQKAGFFNKLRVMIGHARALREEESHLYMLYGHILTTFCETAGDPLDVDRALGCEPQSAFAAPTGTRFDRRIPDFTVMVTFFHDIDVVDRFSPSYRSPTLGFWLEVKPLNCKDNWMSDEGHRTARRDVWSHLAQLNEQAMFAFNHFTGDTFYGMLILGIYFSVFEYLRPTPPPTHPPSPSELHPPTDGNQPQKRQKRKRDHDVSTYRAYVDQEVEPEYFSLTRVHPRTLYYCEPILMNDGEDFNPLFRKALWDIMAWREMDFPFQPSFFTLPRMTIMSQKHLWKWLVKTEMNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVZ4</accession>
    <name>A0A401GVZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616847.1">
        <property type="nucleotide sequence ID" value="XM_027761046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVZ4"/>
    <dbReference type="GeneID" id="38782851"/>
    <dbReference type="InParanoid" id="A0A401GVZ4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="19632" checksum="4706DDF2D5BEE052" modified="2019-05-08" version="1">MDQRCVSVPMISLPGGADDENDVDGVPTIAISITDADSPPRIAVTGPSMSTENVCTPSPPQGMVSSGSSQSSMSSLQCVEPLRCKIFKHAEGSLACDRCGGTIVGRMVSTMGMQWHPACMVILLVCLRPPSSLKARARPPYAHAWPSSLRTCAHPSCVLTFALPAHPFSLGTRAHPPCALTPILPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW26</accession>
    <name>A0A401GW26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0903050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617339.1">
        <property type="nucleotide sequence ID" value="XM_027761538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW26"/>
    <dbReference type="STRING" id="139825.A0A401GW26"/>
    <dbReference type="GeneID" id="38783343"/>
    <dbReference type="InParanoid" id="A0A401GW26"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="154" mass="16756" checksum="A4288A547D41CDDA" modified="2019-05-08" version="1">MLSGSASQEQLRQPSLMPIPSHAPSPLTVGAMLSTVPSDPSHTTNGLLAPQPPASSPIALHAICSMRFLARMASWAQLINTNNDINEAARATAPSKMKVKEKVKEAKEKGEGKKKKKEEEEIEVKKKTIWSLGSSFIRTLRHTKQTLLHLGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW45</accession>
    <name>A0A401GW45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0903250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617359.1">
        <property type="nucleotide sequence ID" value="XM_027761558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW45"/>
    <dbReference type="GeneID" id="38783363"/>
    <dbReference type="InParanoid" id="A0A401GW45"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="1">
        <location>
            <begin position="44"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="442" mass="49707" checksum="546291C786CF6C68" modified="2019-05-08" version="1">MQEFARMQPAEAIVVPVEMAITDSDGSESDDASVVDHQLQVISKLIRKGDDVILHSPFDDTEDEWVGRVLTICEDSSKNQFAKVRWYWSRHDVAKWIGSFDAQACAPYERIYSDMIDIVSCQSILRPVNVYMYDEGLLEVSEIGPMDFFWRSSLDHKRRSIKPKITEDSCLLLCTKPYNPFPISISHAGQSQGTSALHDDPPDVMHFCPRPDCAQWYHTMCLVDSGSFDSPSVRYRGDRSIRLLAVAPDVDFPCPLLNYFCEESSDEGPYSLSEALPLMDMPSDIFTHLPPSLLSIAQGPIIRQPHMGSTDGVLPFGNVVEVVLARRFIYATFEAVCAQPGGSWLSQINSLTQQVEAMERGDQVGDLEWVDNPDDLAGERVVHNTDDDRHIKALEKVCNELAEVSLLASPYAPYWEKREQDLTIETWMNCPPLICPKCHGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW51</accession>
    <name>A0A401GW51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0903240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617358.1">
        <property type="nucleotide sequence ID" value="XM_027761557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW51"/>
    <dbReference type="STRING" id="139825.A0A401GW51"/>
    <dbReference type="GeneID" id="38783362"/>
    <dbReference type="InParanoid" id="A0A401GW51"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8693" checksum="A0805D02BE3E1C70" modified="2019-05-08" version="1">MSAQGLCGSDASVSMKILFVLRTMINPEVQKQGQAEIDSVIGHDRFPQLADRDQLPYVSVLYLEVLPILLHPLVFRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW58</accession>
    <name>A0A401GW58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0903090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617343.1">
        <property type="nucleotide sequence ID" value="XM_027761542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW58"/>
    <dbReference type="GeneID" id="38783347"/>
    <dbReference type="InParanoid" id="A0A401GW58"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="67" mass="7339" checksum="4645AB0CBC81DDAA" modified="2019-05-08" version="1">MRLNSPSLSPPPSPMHRTPSTSNPSTRSSTEDDTHNSSRGIAWAYFSQASTTFTEMDEDCCSSVKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWK3</accession>
    <name>A0A401GWK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxypeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0904590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617493.1">
        <property type="nucleotide sequence ID" value="XM_027761692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWK3"/>
    <dbReference type="FunCoup" id="A0A401GWK3">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWK3"/>
    <dbReference type="GeneID" id="38783497"/>
    <dbReference type="InParanoid" id="A0A401GWK3"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="296"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE86580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="593" mass="64302" checksum="63D2D051C7B23A4F" modified="2019-05-08" version="1">MSSSNSEKGALLPWSAPHPAHRQRRYRGRRAGWILLAALVSACLCTLARVNVLSVSNPFGYAAAEAELSALCPQVAPLIPVKNREVWESLGETIKTPDFLTRAVDWLGGAVRVATPSFDEMLDVGVDPRWEVFGPFHDYLLGAFPKVHASLEFTKVNTYGLVYVWTGSDASLKPLLLTAHQDVVPVNPDTYDKWVHPPFSGYFDGTRIWGRGSRDDKSGLIGSLSAVEALLERGFKPTRSVVLAFGFDEETSGLHGAYAIGQYLLSTYGENAFAMLVDEGGKFGEEHGGVFARPSIAEKGYIDIRLTVTSPGGHSSIPPAHTTIGILAALLVEYEEHPIEAHLKRDTPVYWHAQCLAAHAPELSPSLRRHLARSVKSDKALRKAQEELFEDHTFEALVGTTQAIDLIDGGVKTNALPENAVAVINHRIATDSSVGAVKERATALFKSVAAGFNLSYTAFGSRITDVDARAYGTLTLTDAFGTALEPAPLTPTGPDAAPFLLLSGSIKATYNDHRALLGDGITVMPSLVSGNTDTRYYWPLTQHIFRYSHTNGGNGTGLEGVHTINEAIPIVDFLEIIRWFTTLILNADESTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX60</accession>
    <name>A0A401GX60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1000570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617728.1">
        <property type="nucleotide sequence ID" value="XM_027761927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX60"/>
    <dbReference type="STRING" id="139825.A0A401GX60"/>
    <dbReference type="GeneID" id="38783732"/>
    <dbReference type="InParanoid" id="A0A401GX60"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="211"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="476" mass="53179" checksum="AF3E987DAF20F229" modified="2019-05-08" version="1">MYYTCLSSLSDVPFLSSGRPAFLRRVFAPPRQSRTTYSFNMDELDRTYGVVFIGVLISAVLFGVTNLQVFIYFQRYSRDSIWDKVSVCCLWMLDAAHLALCGHLVYYYLITNYLNPLELLKVVWSFKAQIMIDAIVVIFVHTLYTIRLWKMAAVESGRPLIRRILLIFVSMIVFLGYGVAALLCYEITQFELYTDLLQDRWVTYVPFGTATFIDTIIAGSLCFLLARCRTGFHEMDSTITVLMVYTLNTGVLTTVCSITAMATFSALPDTFTVLCIEFLVTKMYINSFMAMFNARNKLRSQAPASEEGLTPLKHLSSGGSSNYTTTTLQFSSHGHPSALVLGPDAHTLRYSEPPLSPLSPLSPLSSQSQCFASVEKDEKGMYRLPSMSFAPLSPPRRTWRKPAPEMDAGAGLGEDIYTQYKRAPRRVSRSTVSEMYEWTPGGSASQVDAPDAGSFARPGDSTDELYFGVGIALTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX95</accession>
    <name>A0A401GX95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">La protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1000980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617769.1">
        <property type="nucleotide sequence ID" value="XM_027761968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX95"/>
    <dbReference type="STRING" id="139825.A0A401GX95"/>
    <dbReference type="GeneID" id="38783773"/>
    <dbReference type="InParanoid" id="A0A401GX95"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014886">
        <property type="entry name" value="La_xRRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51939">
        <property type="entry name" value="XRRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="61"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="158"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="XRRM" evidence="8">
        <location>
            <begin position="318"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="56798" checksum="32E08812F17CAE25" modified="2019-05-08" version="1">MSEVLSEVPAKEEKGEEPDVKTCDVPATGDSERSQETTEVVVEKASGEVKTGEGSGDGAIAKEDDSEMLHAMRQIEFYFADSNLPFDKFMWTLHTANPEHWVPIKTVASFKRMREFQSLGLEWVTKALARSTELEVDAEKGMVRRRTEVQEPKGQLERSIYAKGFGPEESGLQRRLEDLFNKYGKTNAVRMRRMDPTKEFKGSVFVEFADYKSVEAFLNADPKPTWNGEKLLVMSKEAYCEMKIKEKGLTGKAATIRRQNITGQGRKGFNAFKEMEDKDKKKGKEKDKPKPEVWLDFLGNKIKVHEEDGGTIKNEDVPLVRGASLKFEGSIEDVSFDEVKTPLKERFARAPFVKYTKGEKLGLVGFDKSLTEDEITYVKETLKTLSGAEVTWSVPDEETEKAFQLERATSAAKRVMSFSQRGGRGGGRGGRGSRGGRGGRGGRGGRGGRGGRGGGRGGESRDKEGDATPATTSNGEQAGEKRKRAVEPDGGPDTGIRGQAVPIIQSAKKAKVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXF3</accession>
    <name>A0A401GXF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1001310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617800.1">
        <property type="nucleotide sequence ID" value="XM_027761999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXF3"/>
    <dbReference type="STRING" id="139825.A0A401GXF3"/>
    <dbReference type="GeneID" id="38783804"/>
    <dbReference type="InParanoid" id="A0A401GXF3"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019108127" evidence="2">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="16"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="385" mass="40446" checksum="6266D947AF63E563" modified="2019-05-08" version="1">MKSAILAATILSLSRVALGNYTLVQSFSGSNFFNGWQFYGNYDNTTEGDVTYVNQTNATAFNLAYVNPAGNAIIKVDNTSFVPYNEKRNSVRISTTDYFSVGSVFLMDAVHMPYGCSVWPSFWTKGQAWPSGGEIDIVEAVNMMTNNQMALHTNEGCTIASSSLSGSLTENNCNSTAGCTVTENQANSYGASFASSGGGVFATLFETSGVSIWFWSRANVPTSVSSATTSIDVSSWGTPSANYTSTDCNINEFFQPQQIVLDITLCGNWGGIASIYSETCPVQGTANASTCYLDNVINNGTSQYANAYFEIPYLKVFSANGTVITPSGSASGTGSNVGLPTSTSSGSSPSGSSGSKSSSAVRWDPTVLSIGMSFAVAALGAWSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYW2</accession>
    <name>A0A401GYW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1100280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618266.1">
        <property type="nucleotide sequence ID" value="XM_027762465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYW2"/>
    <dbReference type="GeneID" id="38784270"/>
    <dbReference type="InParanoid" id="A0A401GYW2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8509" checksum="33B4C57CCC030494" modified="2019-05-08" version="1">MGFNWPWKPKSMALCQGMALSPSYSLTGRIIPTPSPGRCVAIFHNEFLTNDATDWHLARMLVAWYGYNDSPTILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZA0</accession>
    <name>A0A401GZA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1101740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618410.1">
        <property type="nucleotide sequence ID" value="XM_027762609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZA0"/>
    <dbReference type="STRING" id="139825.A0A401GZA0"/>
    <dbReference type="GeneID" id="38784414"/>
    <dbReference type="InParanoid" id="A0A401GZA0"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF5">
        <property type="entry name" value="4-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="34374" checksum="CCF2AC2997335244" modified="2019-05-08" version="1">MSFAPNRGLGVPIAEFNAAPKSPRVVVTGGSGKLGRSTVLDLVAHGWNVVNFDKAAPPKDGHQEVVFVRVDLEDMGQVMENLVEVDSRYRGVDAIVHLAALPAAGLEASSHQFRLNTMATYNILEASRKLGIKNLVLASSETLIGLPLDPWLPEYIPMDENSERRPESAYSLSKLVGEVMADQYCRWDPTTKIISLRFSNVLLPEDYARFESWQNNPKVRRWNLWGYIDARDGAQGIRKSLEYKTTGHHQYIIANNNTVMREPNSELLAKEFPGVPYKSTPGHNDTLLSIEKAKRELGYAPQFDWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZH3</accession>
    <name>A0A401GZH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1102400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618476.1">
        <property type="nucleotide sequence ID" value="XM_027762675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZH3"/>
    <dbReference type="FunCoup" id="A0A401GZH3">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZH3"/>
    <dbReference type="GeneID" id="38784480"/>
    <dbReference type="InParanoid" id="A0A401GZH3"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="87"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="199" mass="22246" checksum="A5DA387B26C5564D" modified="2019-05-08" version="1">MSDKDSESNPTPQQPLPPGMVLGPDGKPCKICTAFRYWKPRKQNSSKAPSHDGRNSTTSMMAAMATGQSLASQSEPEPEPETRPEYCPPDVEQLGRATWTFLHTTAAYYPERPTPTQRANMLMLLRSLPILYPCTYCASHLDTNMQDNPPNVSGRVALSRWLCERHNDVNVRLGKDKFDCSIEKTDERWKDGPADGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZQ5</accession>
    <name>A0A401GZQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major royal jelly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1103240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major royal jelly protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618560.1">
        <property type="nucleotide sequence ID" value="XM_027762759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZQ5"/>
    <dbReference type="STRING" id="139825.A0A401GZQ5"/>
    <dbReference type="GeneID" id="38784564"/>
    <dbReference type="InParanoid" id="A0A401GZQ5"/>
    <dbReference type="OrthoDB" id="7776143at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="MRJP/yellow-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009:SF18">
        <property type="entry name" value="PROTEIN YELLOW-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PROTEIN YELLOW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="51659" checksum="72048AF416756433" modified="2019-05-08" version="1">MALRLKSRGQLHLPTPSHAHGVHKEAGHVHGMNNVLALLAAAASAQSNPFDFPEYPPAGTPDWNEILASAQGVRPYGIATDPALANVLVHYDTGYFGPQIELIHAYYNYVPTGVGASSDGSVFTCFPRGNETFTLAILSSPTTEVAWPNEDWNTPETFSNSSNPGYSIATSKFLFVQSVVVDGRDRVWALDTGRPRVNGTVLLAAVPGGPKLIGFYLNGTNFASYTFPSDVVYADSSLNDVRFDLRGGGYAYITDSSPQRPAIVVVDLTTGQSWRHLESHPSVSLDLNFVPLYNGVPFYYHNDIAPNAVINYEAFAVDGIALAADGEHLYISPLSDRHLWRIPTSFLKVQPSSKNPYAGLLARQAVQLATETGSNADGLETDASGYIYSGSIEHNGINRFNNNTGIMEPFIRNPVIQWPDTLSVVTLQSGGKYLYFTSNQLWLSPDYQNGTDLRTKPYAMFRVPLEAGKATQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H001</accession>
    <name>A0A401H001_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1104240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618660.1">
        <property type="nucleotide sequence ID" value="XM_027762859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H001"/>
    <dbReference type="GeneID" id="38784664"/>
    <dbReference type="InParanoid" id="A0A401H001"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="56" mass="6176" checksum="632A65B3BC7709D1" modified="2019-05-08" version="1">MQGRENKHSFRLAEAPPAKLSTWKTFHATPHIDISTKLLKSVTADGGHGRELSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Y9</accession>
    <name>A0A401H0Y9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1202920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618976.1">
        <property type="nucleotide sequence ID" value="XM_027763175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Y9"/>
    <dbReference type="FunCoup" id="A0A401H0Y9">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0Y9"/>
    <dbReference type="GeneID" id="38784980"/>
    <dbReference type="InParanoid" id="A0A401H0Y9"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE88063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="108" mass="11712" checksum="604361E1A41964F8" modified="2019-05-08" version="1">MPFASGDAGKGAGLFKTRCAQCHTVGAGEPNKVGPNLHGIFGRKTGQVEGFSYTAANVNKGITWSEETLFDYLENPKKYIPGTKMAFAGLKKEKDRNDLITWLKESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Z4</accession>
    <name>A0A401H0Z4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1203240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619008.1">
        <property type="nucleotide sequence ID" value="XM_027763207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Z4"/>
    <dbReference type="STRING" id="139825.A0A401H0Z4"/>
    <dbReference type="GeneID" id="38785012"/>
    <dbReference type="InParanoid" id="A0A401H0Z4"/>
    <dbReference type="OrthoDB" id="2751906at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="39436" checksum="3B8D2B5AC3B6FE29" modified="2019-05-08" version="1">MRLLVTFFPDIELMPFELSDDYTDSSVVLSVAVIGDPHFKPILPASDDEDDEGGYSGSSESDHYAVDSEDEDENVLHSDYATIYRGIMTRNDTGTCTDVVLKCSYRNRHADIVEEGSFYVNQLKPLQGDAVPECYCLFRGTGPKGYEIVCIVLEDCGKTVGSPFATLPLLDRTRILSQLVKIHYAGVMHRDVHEGHVVERGGIFKIIDFHDAVGHEPACDFRFADDLHAGEPEPDGDEAGCIPLWRQCKEFEIWDDGRIFIPLSGMAFRRCNGWPRQEVIDKLMPSCISHWNTIVKHALQEYFHLIQKELDNGVSMELLKKNANERFLKSLRPADVVPNFVFPQYRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1C9</accession>
    <name>A0A401H1C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1300380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619137.1">
        <property type="nucleotide sequence ID" value="XM_027763336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1C9"/>
    <dbReference type="GeneID" id="38785141"/>
    <dbReference type="InParanoid" id="A0A401H1C9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="193" mass="21585" checksum="45F9434863F5D9A1" modified="2019-05-08" version="1">MNGVKGSQPKARWLASLVTGAGKDLCKETKRLSISRSPPLPIGYERRKQDVPQVKPSYVTGTEFRKFSPYATLRQTCAKAENTQTPVVVSVVEVFEMDDVDVGDGSSEIGESQPCLFPRGYIPSPLNPWKHVFPHCTPDGSRSPRKNSIVKSKYSPKGSKFDHEPPLIQILFRSRFPKSGCRRSNSRLCYDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H220</accession>
    <name>A0A401H220_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="11">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1302730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="11"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619371.1">
        <property type="nucleotide sequence ID" value="XM_027763570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H220"/>
    <dbReference type="FunCoup" id="A0A401H220">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H220"/>
    <dbReference type="GeneID" id="38785375"/>
    <dbReference type="InParanoid" id="A0A401H220"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE88458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="422" mass="46360" checksum="FB843732B6D29707" modified="2019-05-08" version="1">MHAVKPSSFCRSCTANLRRTSHRPRAAVRAGSSLASPKANNFAQYFFHNDRWGPLHRSHYQDASPSTPISQALTPQSSTIRAFKVSETLTPRRLLRIYAELSKSRLTVLVVLTAMAGVALSPLPTSLPVLLSTAAGTALCSASANALNQLQEVPFDAQMARTRMRPLVRRAISPLHAAGFAVVTGVAGPAVLWTMVNPITAFLGAANIALYAGAYTWLKRRNVFSTWVGAVVGALPPLMGWTACGGQLLPSSSYPIQLFLPSFLSTTTLDLHLIDNPLAPLALFMLLYSWQFPHFNSLSHLVRESYAQAGYRMLSVVSPAKNALVSLRHTLLLIPVCSVLVPISGLTTWAFAIASVIPNAIWAEAAWRFWRSGSEKHARKVFQHSLWYLPVMLGLMMFCKRGMDWGSWIGVRAEEHEEDVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2J3</accession>
    <name>A0A401H2J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1400600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619568.1">
        <property type="nucleotide sequence ID" value="XM_027763767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2J3"/>
    <dbReference type="GeneID" id="38785572"/>
    <dbReference type="InParanoid" id="A0A401H2J3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="60" mass="7015" checksum="C221DA41EBAC286B" modified="2019-05-08" version="1">MREAELKNFDDNKENIDPDDLNRAKIGRMSSDGQFLSDPWSSFRADDEPFGYKVLDCEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H343</accession>
    <name>A0A401H343_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High-affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1402140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619722.1">
        <property type="nucleotide sequence ID" value="XM_027763921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H343"/>
    <dbReference type="STRING" id="139825.A0A401H343"/>
    <dbReference type="GeneID" id="38785726"/>
    <dbReference type="InParanoid" id="A0A401H343"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AA_transporter"/>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="594" mass="65429" checksum="33898BE4C9AB2031" modified="2019-05-08" version="1">MSLLRFFLLSRREDQVATPSNVVEEERDNDEKLPTKDSDDVVSIKGPVHDDNSDLNPGELTFEEDAAGGMGRHLGVFSCTMLIIGRVIGTGIFSTPSSILNSVGSVGASLMLWVLGFVLSFCGLFIWLELGTMFPRSGGEKVYLEAAYPRPKYLSTVVFAANAILLGFTASGCIAFASNILISAGKEATQWSSRGIALGVIVFVTILHGLTPRLGVIVMNLLSIFKTFILLFIVVTGWVVLSGHTSIKDPHANFRNAFAGSSHSGYDYATAMFKVLFSYAGWLNVNYVMNNVRDPIRTLKIAGPLGLGICTIFYLLANVAYFAASTKEEIANSGVTVASLFFGKVFGTQAQRALTVFVALRVRRINRSHKIELIDRMFFDLSHIQKRRHGGTSLPPSIAIVYSHPCAKAFAAARINQELAKEGIPLPFGNRFWASNWPTGKTPLPGLIIHIIPTIIIILGPPPAVAYPFILDVEGYPGQIINFFVVIGLFWLRWHKPHAVRPFKVWLPLAVLFLAAAIFLLVAPFLRPPNGIGDTPPLPYYLYCIVGIGVMLFGVFYWAMWRVVPRWFGYKFVPRKDTLADGTVLTLFSSQKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3K0</accession>
    <name>A0A401H3K0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1500090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619920.1">
        <property type="nucleotide sequence ID" value="XM_027764119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3K0"/>
    <dbReference type="GeneID" id="38785924"/>
    <dbReference type="InParanoid" id="A0A401H3K0"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8640" checksum="8F3FB5B9AF2A8DD4" modified="2019-05-08" version="1">MKMAGKSPSSREMQQHDTAVTLLEFFHTGEFDGRMRLSTEKAERCSATLEQFRQLDKEDMLKTLGYWARAGILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3S3</accession>
    <name>A0A401H3S3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1500550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619966.1">
        <property type="nucleotide sequence ID" value="XM_027764165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3S3"/>
    <dbReference type="GeneID" id="38785970"/>
    <dbReference type="InParanoid" id="A0A401H3S3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="96" mass="10390" checksum="E8B80AFEE33E1399" modified="2019-05-08" version="1">MSMPPSCHFTFQPSPSNPELTLPDFAHGSFYDAEGLPDIYADAPNTYLSWGSSDVQPSLEDTLSRGAAEAQFHAVSLLGQYGADQHTRTARPHIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3X5</accession>
    <name>A0A401H3X5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1501520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620059.1">
        <property type="nucleotide sequence ID" value="XM_027764258.1"/>
    </dbReference>
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    <dbReference type="STRING" id="139825.A0A401H3X5"/>
    <dbReference type="GeneID" id="38786063"/>
    <dbReference type="InParanoid" id="A0A401H3X5"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="389"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE89146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="660" mass="69407" checksum="1105493F4DE2C63B" modified="2019-05-08" version="1">MSSFFAQSFKPQVVSRQEGFHPLPSPDPPSPSSPFDSNANANNHHLFMSPFLPDPFRKFPAVDAHLDPFSDDLASFIGSAPSPHHHAQSSQHAQSNERSTQSPAYDDYRPPPHNIFDISAPTPHHSHQQAYQQQQQQQQQQQQQGAHAYSLPPASALHPHGLHDFTTHAHFNSTLPALGSSMRYEPPPASAGADPASVPSFSSSHLSSLSTFPDFHMPPSGRTPSPHTPAAPPHAASFSRSRSRSRPPTAHPHEPPSTNGGPARRTRAKRGSLSSVSPPPLHRGHTQPLVIPGPGSAVPLGARAPASPLGLHSATGSGWFLPGPGEFLPTPDSVHGGFSAFTGPASMSSVGGATALGVSPKDSPVAESAPPPGDVAMKQALLANEKRRRRRESHNAVERRRRDNINEKISELATLIPECLLDPNATLTMPASLSASGEDLLFGGAPAKEKDKDKGAASPAESANGKEDKDGSAEPEDGAGAVVKANKGMILRKSVEYIRYLQQLVSAQASRNRDLEQQLSAFRVGGGAPSSSAAAAAAEDELGALMLHEEVDAFGFFAGIGGAPHAKRQRARLERVDETQMEVDDASAATSTGEENDGEGDGDNEMADASASLPSPDPDPDEGASQGQEEVRGRRGRPGAGGVGGPVKVNGVKKEGDMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4S0</accession>
    <name>A0A401H4S0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1600740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620325.1">
        <property type="nucleotide sequence ID" value="XM_027764524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4S0"/>
    <dbReference type="STRING" id="139825.A0A401H4S0"/>
    <dbReference type="GeneID" id="38786329"/>
    <dbReference type="InParanoid" id="A0A401H4S0"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="224" mass="25286" checksum="86E9057BBF12A1B1" modified="2019-05-08" version="1">MHPGPAQRLWSQSRMASTSMHHLYPFPTHAHPTPHQIFHLPPGASQKDIKARYYDLVRVHHPDSPMCRNLSAEVRHVRFRSITAAYDALRGKGKHGANAHDAVRAELERRRRAQRRSRERAEFAGAAAFSDSPWHAEADDRWKDWLIITAAVMSLAAGLGPALLWPAAGMSDRRHQAASQNLAEARRVAKVHGTEQRQEIRRRVEESKRSQSGEDGSQPQLDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4S4</accession>
    <name>A0A401H4S4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1600640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620316.1">
        <property type="nucleotide sequence ID" value="XM_027764515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4S4"/>
    <dbReference type="FunCoup" id="A0A401H4S4">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4S4"/>
    <dbReference type="GeneID" id="38786320"/>
    <dbReference type="InParanoid" id="A0A401H4S4"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="517" mass="56030" checksum="1D2F75DD12F68718" modified="2019-05-08" version="1">MQPFSHVFGQQGKKEHGFDNVKTSNSAWDTNLIAASSRHISINWNASGGGAFAILPLPTPFGPLPHGFPYKLPELIPLARSHTGPVLDTDWSPFNDSVVASAGEDGKVMIWKVEDSVFEGWGQEHWEPQDFDPVARLDVSPRRVGQVLFHPTANNVLASTTGDHIVKLWDLENPENPRSVLSGHGDAIQSLAFNPAGNLLVTTCRDRKLRLFDPRAGGEAGARVTWMGERDSIATTGFSRMSDRQVGLWETGGLTNIKTMTIDQTSGVLMPFWTDNNILFLAGKGDGNIRYYEYEHDQLYALAEYKSSDPQRGMCFLPRRALNVSECEIARAYKVAGSSIEAIAFIVPRKSESFQADIYPPVPSSEPALSPSEFFAGKTASPKLVSLENGSISFGAPPSTLPSAPPPHAAPAPTRSTSAPAPAPAPVPVPAISIHVDPTPSPVVIKSDPSPISPAELRMLVRSQTIPEDEPSVSMLKDENARLNAELREARAQIRNLELQVESIKANARKAAALLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H548</accession>
    <name>A0A401H548_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1602200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620471.1">
        <property type="nucleotide sequence ID" value="XM_027764670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H548"/>
    <dbReference type="STRING" id="139825.A0A401H548"/>
    <dbReference type="GeneID" id="38786475"/>
    <dbReference type="InParanoid" id="A0A401H548"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="532" mass="59518" checksum="1396EF237E782197" modified="2019-05-08" version="1">MLAYGNHPFQKPSADLVVASADDIAFRVHKNILAEASSVFEHMFGSPQPQHDSSDAVRGDEVFDGLPVVHLTEHSTTLENLFRLCYPVRDPIITSLEAVRDTLVAATKYDMEEATELLVARLKEFAGAKPLQVYAIAYRHESEEVALAAAKGVYVHGLCSRYSPEMEDISAGAYNRLLLYCRAMKKGKTYTDYLCQPRRHSDNSANSSVPTTDGAEPDNASTNTLSHPFTMSNADFSNADFILRSSDHVPVDFHVHRIVVEMASPVLTQKIFQAVSAHHTATDRSDADLPVAVLEEKGGTISILLQLFYPNFLEPDLEDVQELVTLLAAAQKYRINKAVQLLSARLLAQNAEPMKVYLIACQFGLTALAKEGAKRILRLDDDDLEIYHAEMEDISAGQYYRLIQYHRVHREVVDRYTSDGQWISVEWRTRLRKQCTTRSINNGQGQSLPCWCTPYFRCLRDQKIGDVKAHDPFHLSIDVTTGAVESAFKRLTVSDACGGCRSSDAVLLMLQFSHYLTQQFSSAVSMTELEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H574</accession>
    <name>A0A401H574_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Mitochondrial chaperone BCS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1602260</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620477.1">
        <property type="nucleotide sequence ID" value="XM_027764676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H574"/>
    <dbReference type="STRING" id="139825.A0A401H574"/>
    <dbReference type="GeneID" id="38786481"/>
    <dbReference type="InParanoid" id="A0A401H574"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="249"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="419"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE89564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="564" mass="62724" checksum="834A9492698152FD" modified="2019-05-08" version="1">MNGTAPANISSVTASLADVLDMPPEFSALLTAFLSLAALRDWFKLAIIGGFIETCRRLYSTSWTGFLDKFWVVASFDDDDTSYNWILFWLSKHPTWSKARRIEVTTRDFDLNSDLMEDDDEDRQMTYIPSLSSKYSLWYKGHYMTVSRSEVQNGTWRTKERVEICILSRDTSILSDLVLEAKTYYKAAKDHLIAIHVSDPSNNWRRVASRPKRPLKSIILDPGIKDLLLNDAEDFLQSRDWYSDRGIPFRRGYLLYGAPGSGKTSIIQSLAGELGLDVFIISLSRSGLDDSSLSELISELPKRCIALMEDIDAAFHQGVRRDRELDATPDSGKSEKQEHDKERDSPLSRVTLSGLLNALDGIGAQEGRILFATTNDYHALDPALCRPGRMDLHIEFKLASKLQAEELYKCFYMPSGPAAEDAKAQSDTSGDSGYASPASSAAKDLADAGPPSPTGSTDSTTLSSSDAEKQSLLYTGSLSSFRAPLLPREKVHELAARFAETIPERELSMASLQGYLMTYKIRPYEAVDGALAWVVKQLEEKEKAKSARGRSGLRPDDVTPDNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5H7</accession>
    <name>A0A401H5H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620609.1">
        <property type="nucleotide sequence ID" value="XM_027764808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5H7"/>
    <dbReference type="GeneID" id="38786613"/>
    <dbReference type="InParanoid" id="A0A401H5H7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="150" mass="16617" checksum="8DE5740E3C734BAC" modified="2019-05-08" version="1">MTLPPLTHNLARRTRPADTLLSTSTSTSVPPPLDHPPARRPHPIPHVQARSENERTTQPGRSLVRVRYGQGPGQLTTATAFPGRRDQAGWRQRRGLLVVSGRPGIALQGGTLDVMCRCRSQRVVPTPPRVCRNLTRCAVGRKLTQRRSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5T7</accession>
    <name>A0A401H5T7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1701310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620719.1">
        <property type="nucleotide sequence ID" value="XM_027764918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5T7"/>
    <dbReference type="FunCoup" id="A0A401H5T7">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H5T7"/>
    <dbReference type="GeneID" id="38786723"/>
    <dbReference type="InParanoid" id="A0A401H5T7"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="366"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE89806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="457" mass="51073" checksum="613E950C83A5D0BD" modified="2019-05-08" version="1">MVKISVLQHAPSAHLPARPGDPTPTSRNLDPLMHPFARGRERMRALNAAKMERMFAKPFLAALEGHVDAVETMARKPESLNVVASGSWDGGLIVHDISRRTKVIYVEQAHKGKVAGICFADGERLLSCGVDRNIKLWDIRPSSLGVDEDGAGSSTSRNPLSIFPGKAAFNSIDHHRSDPLFATASNLVQIWDETKSAAISNLTFPTSTETISGVRFNLSEPSVLASIGSDRTFTLYDIRTGKAERRIIMQMRSNSLSWSPTFPTTILLASEDHNLYTFDIRSLKTPTQIYKAHVAAVMSCDWSPTGLEFVSGGWDRTVRIWKEGVGSSPEIYHTKRMQRVSSTLFTADARFVLSGSDDGIVRIWKAHASEKLGVVTARERAAIEYRESLKERWKMDSEVGKVSRRRHIPKPVYKAAQLKRTMLDARRVKDERRRKHTRAGESKPKAERQKMVIAEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5Y6</accession>
    <name>A0A401H5Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1701730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620761.1">
        <property type="nucleotide sequence ID" value="XM_027764960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5Y6"/>
    <dbReference type="GeneID" id="38786765"/>
    <dbReference type="InParanoid" id="A0A401H5Y6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="95" mass="10031" checksum="385F4222D6BA24A5" modified="2019-05-08" version="1">METPMRMSGGAADHLLARTSEHSPSIATCTSPLDGASLRLLVLQKADRSGTQIIYILPSSLIAVPVGGEVNQQFKKAAEALDAKLQNLVPQMACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H652</accession>
    <name>A0A401H652_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1702440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620831.1">
        <property type="nucleotide sequence ID" value="XM_027765030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H652"/>
    <dbReference type="STRING" id="139825.A0A401H652"/>
    <dbReference type="GeneID" id="38786835"/>
    <dbReference type="InParanoid" id="A0A401H652"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE89918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="36550" checksum="A125CF43AFD84E3C" modified="2019-05-08" version="1">MDTSGEVTSVHSRFLCAAAIAGLLTWICLKRQSVRGNHAAIGYCLAFSSFYLANKQLHTTPTPLVFTCLIFGVHTLSVLLFTVAYRLSPFHPLFTFPGPRLWWISSLRLGYVSFKGKRHLILDELHKVYGPFVRIGPNTLSINTLSAAALYNANYDLDKSEAYNTPGHLPVVAIFFKQRTKKLHADRKRIWSTAFTGPTVVHFFPLLERRTMELMKCIEWRQTRAESKTVDLSECLCHWSYDFMGDMAFGGCNDLELMKRGDPDDLVMGGKRATIALDRHVVAESFSHSQPLDVSVALVNRLGSRTSSGTYRWEGPGSASVTLPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6M4</accession>
    <name>A0A401H6M4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1801110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621000.1">
        <property type="nucleotide sequence ID" value="XM_027765199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6M4"/>
    <dbReference type="FunCoup" id="A0A401H6M4">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6M4"/>
    <dbReference type="GeneID" id="38787004"/>
    <dbReference type="InParanoid" id="A0A401H6M4"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE90087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="310" mass="34004" checksum="3C6E0F973D59BEBC" modified="2019-05-08" version="1">MRFRANVENVATFYRIVQAIEKLQKRCIIRFTETDMHIICNNDVNEGGIQVWSQIKVPSLFTDYRIQSNAQNEITLTLSSEALLSALRSASPSGSQGASSSSFASDAEVVMKLAKKNDQAVLNFEMAGTTRMGRRVRVAHDVRIEVLRPQDVGKLREPMCPEPEVHILLPPLAKLRTVVERLRPLAADVVAVRANASGCLQVSASTESARVDVSWSGLTNPIMIRDGNSQDPQASQNGNDPDARDPTQKYGVLVSLRSFTKFLNSHVVSTTTIACICQNHAMILYVYIGEVADAGGVLTFYIPAIIDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6W0</accession>
    <name>A0A401H6W0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-specific adenosine deaminase subunit tad3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1801430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621032.1">
        <property type="nucleotide sequence ID" value="XM_027765231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6W0"/>
    <dbReference type="FunCoup" id="A0A401H6W0">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6W0"/>
    <dbReference type="GeneID" id="38787036"/>
    <dbReference type="InParanoid" id="A0A401H6W0"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="189"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE90119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="377" mass="41528" checksum="FBC42B59ECF36332" modified="2019-05-08" version="1">MATSVVLGTLRRFSSGALDTSRVSGDSDHDDSGIDFESELTVDGNSDVIIPEDDLPFTRTKLVFEYEEDELSSIRTELAWVVDIPDPKQTTILLKWLKESGLESPSMAHLKRIRRTDSKITIILAFASSSPGPPALPEDAELPAPYLVNVPCSAALTLTSLKLKSSLWPTLYTPPRKGELEDWSRSKVKWAFEAMRRVVREAGQAHEQGEFPIAVYVPIPYDEETRVVSQISRPFMAHDTRKSSGHPLRHSVLNLIRAVADYRTSSTPVNQTPPDAGLDSDSGLTDSAPHNGAHYLLTSLTLFITHEPCIMCSMALLHSRAKEIFYLVPMAGTGGCGGAACVPMLQGVNHRFGIGRWKVTGEWVEKYNLVIDQAVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H711</accession>
    <name>A0A401H711_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1900510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621115.1">
        <property type="nucleotide sequence ID" value="XM_027765314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H711"/>
    <dbReference type="STRING" id="139825.A0A401H711"/>
    <dbReference type="GeneID" id="38787119"/>
    <dbReference type="InParanoid" id="A0A401H711"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="313" mass="33735" checksum="9C8F7B035BEF3239" modified="2019-05-08" version="1">MTTAPDTGSYSTSRGRGRGRGRGRGGRGRGRGRGDVSDEIFGETQQQRTPKPRLTHFLALPIGHHSGLRDSISTFTDALLAASPAIPGLDGSIVIPARRLHFTLGVMALNDADASIAEAASAPAGDSPPSPPRSLPKAVALLEEIRPLLMKMLEGEQLRVALNSVDIMTPEKRDLERAHVMWVGPTPGTEDFKKLKQVSDFVHKTFKDAGLVVDDRRPLKLHCTVLNTVYRKPRVKVRTPFSYASILASEPLQAVSATPVMGIATAQAGSQSPIRGPRSVDFGEWAVEEVQICEMGSWGPEGEYVCVGRCPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Z3</accession>
    <name>A0A401G4Z3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PAH-inducible cytochrome P450 monooxygenase PC-PAH 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0100660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608107.1">
        <property type="nucleotide sequence ID" value="XM_027752306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Z3"/>
    <dbReference type="STRING" id="139825.A0A401G4Z3"/>
    <dbReference type="GeneID" id="38774111"/>
    <dbReference type="InParanoid" id="A0A401G4Z3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE77194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="547" mass="62409" checksum="84FF93AB8C000083" modified="2019-05-08" version="1">MSNTLILYGAISAALIAFAVYRFTTHRSLKYIRGPPSSSFIFGNSVISSHQQEVGDLEFQYVKEYGTVWRQAGCWGRDSLVVADPKAIQHITYKAGYNYPKSLISRYISRQVAGDGILIADSQDHPRHRKIMNPAFTAGQLRTFMPLFRRLSTKFTQKWKDVLRSATTETEQVLNVHAWLARLTLDIIGEAAFDYQCGALDDEESEVMDAYKNMFADSLLYPTKPTILFRSIWKYIPEHLLRLINYIPTREYSRFRRSLTTINWFAKQVIDEKTEACLAGKAENKKDIMSILVKANASEDSRTRLKESEMPAQMATFLLAGHETTSSTLTWLLWELAKNMDYQRKMRDEITAVRARMTARGDSDFSIVDLDSMTYVLAAMKETLRYHPIVYSLVREAARDDVIPLSMPITSVDGEVISHIPVSKGQEVAFSIAVYNRLPEVWGADADKWNPDRFLEIDQSKQTTVGVWSNLMSFSAGVRGCIGWRFSILEMQTILVELLENFKFSIPSYKPDIQRIPSGLMAPMVRDKMHLGTQMPLRVVVLHPEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G676</accession>
    <name>A0A401G676_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized secreted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0105460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608578.1">
        <property type="nucleotide sequence ID" value="XM_027752777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G676"/>
    <dbReference type="STRING" id="139825.A0A401G676"/>
    <dbReference type="GeneID" id="38774582"/>
    <dbReference type="InParanoid" id="A0A401G676"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019283426" evidence="2">
        <location>
            <begin position="25"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="360" mass="38149" checksum="45DF1BDFD14B774D" modified="2019-05-08" version="1">MLVSVRCLAQLIFPLLSLSVGTHASSVRRQATTCNGHAELCGRSFGNVTFVGAHDSYAVSASSLAANQDYNATQQLDDGIRMLQMQAHNSSGTIELCHTSCLLFDGGTLKSYLTSVKTWMDSNPDNVVSLLIVNSDNIPPSDYDTVFQSVGLASMAYAPPSASLPASGWPTLETLINSGKPLVVFLTTEADYQTVPYLIDEFTNIWETAYDVTTTTFDCNVNRTNGDSSTQMYLINHFLDEESIAAIPVPNKAAANVTNGVSGVGSLGQQVQTCASEYGRNPNFMLVDFYEYGNGSVFQVAATANSVTYTPSSPVATPITSSSSSSSSSGAVGGVVVTWGHLGGSFTILLSVLFGVWSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6T8</accession>
    <name>A0A401G6T8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sphingolipid long chain base-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0107640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608795.1">
        <property type="nucleotide sequence ID" value="XM_027752994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6T8"/>
    <dbReference type="STRING" id="139825.A0A401G6T8"/>
    <dbReference type="GeneID" id="38774799"/>
    <dbReference type="InParanoid" id="A0A401G6T8"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="55781" checksum="90E5587B71661E80" modified="2019-05-08" version="1">MSNFFASLTDKAQSALNASPLAQHLPSSITGQGSTDNAGGPLKSHTFETIHHQLRTFQQQYSTSTTPVQRVITTAKGVAIDFDSYSRDSLAHSKELYTWSQQEDADIRDVTDRLAWINYVEGSLASHLATKLNTSRAPFKALRDAEATLSARRNIRNGLKNQIGRLEHEQARGVEPRLSELRRQLQVAETEDEPLEKQVELLKRKAVAESERQKWAAMNEYAEKLLLLSQAANAVLPVLSGVPPTEKQPYTGGEATASVRAVLQHALDNYTAGTTTLQLPPAVDLSRSDTRSFGLTHAQELSRIGSADQSIRPGIPVTPPPTDVGGAPQPAPSDKSNASVQAGQSSQGAGSTSPPLRFSPPPQRTSPPLNPAMLNQTPAPIPIPASTASPIVAPNPMDPTVKIPSAMPTVAETGMPQFAGSAGPGPASGSLRDLRSGKSPVPKQGSGADKLPGYTNPSMTPSDQQQGVPGAPLAKYEKAEEEKKRLEREERERVLAASSSGAAEKHPPVDKDGDQPPSYEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G704</accession>
    <name>A0A401G704_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0108340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608865.1">
        <property type="nucleotide sequence ID" value="XM_027753064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G704"/>
    <dbReference type="GeneID" id="38774869"/>
    <dbReference type="InParanoid" id="A0A401G704"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8230" checksum="D0502297CA79F3A6" modified="2019-05-08" version="1">MWDFIVADSSSNPLYPPHDGHPAYGVGVPDVGQTQPDTPSPSSTSPIAHPSPQHANQLIVTSSTTRSVAFMNHHRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G730</accession>
    <name>A0A401G730_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0108410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608872.1">
        <property type="nucleotide sequence ID" value="XM_027753071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G730"/>
    <dbReference type="STRING" id="139825.A0A401G730"/>
    <dbReference type="GeneID" id="38774876"/>
    <dbReference type="InParanoid" id="A0A401G730"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="116"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="621"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE77959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="770" mass="84160" checksum="03075F5372650A32" modified="2019-05-08" version="1">MASSSSSPEFSNAPPATSQSSVQYSDLSREEVLEDLSSRFILNLPEEELASLERVCFQVEQAHWYYEDFIREQDPSRFPSYTLKTFSEALFRACPLLHHWAHDHERTFQSFMQYKTRVPVCGAIMLNATWDKCVLVKGWKSSAGWGFPKGKINEQEPRPRCAIREVSEETGYDLDGQLDPENVIDLSIKEQSISLYIVPGVPEDYPFQTKTRKEISKIAWFNLSDLPTWKRSKAVPGKFYLITPFIGPLKSYINKRRPRNVARKARQVQNVHVHRNTHPSSEEENGRDGLYPTVHHAHECSSQSSSADNAEPQTPSPQYTAPEVSHAPSESKLSPGTTDVLPAADLDLNGVDPHFARLLNSLSLSASASVADVSDSSANTSLSSRTLSPSASQPNKTAKSTLHHRSSESSDWSIHVPGPARTSSPVMDSVQAGQFTTPSDRSSATVSTTSHPTTPSTTSVINVDRVSSNSTSTPSMIISTTSPRSAAAVPSSMTHSPIGSHARRGSVATADISPYLSRPRDIPKEMRYISMLESVARESDRMSSRMGHHAAFSQSVQMQSMDRSSFAPAPPASVPPSMHEGRMESPVIYSSRPAASTMFTPGVGQITPVYPPSFRDPFTVRPRTSNAFHPSPYPPAPLPAPGVNSRYQMQSNDPRGYPPPPPQPMAAYQRPFHQPPLTGSLQSVPQPYPPVAQPSLRVVPPHQLPASRYGEPPPLSAPAVSPSFSFANRANTSRPANNAHLLSILNSPSAPLRVAPNVVHPGVLHGTGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7B4</accession>
    <name>A0A401G7B4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0109290</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608960.1">
        <property type="nucleotide sequence ID" value="XM_027753159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7B4"/>
    <dbReference type="SMR" id="A0A401G7B4"/>
    <dbReference type="STRING" id="139825.A0A401G7B4"/>
    <dbReference type="GeneID" id="38774964"/>
    <dbReference type="InParanoid" id="A0A401G7B4"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="40"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE78047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="744" mass="82811" checksum="EAC4372650ECAC85" modified="2019-05-08" version="1">MSTVSDAVKQAFTAATQNPKVADLHRATIDPSANPTKGLTTDHGVFVSDTDNWLKVTDGEGTGPSLLEDQIAREKIHRFDHERIPERVVHARGAGAHGYFKVYDDRASKYTYAPVLTDASRTTPVFVRFSTVQGSRGSADTVRDVRGFATKFYTQEGNWDIVGNDIPIFFIQDAIKFPDFVHAVKPEPHNEVPQGQSAHNNFWDFVGLQPESAHMIMWVMSDRGIPRSFRMMQGFGVNTFTLMNSAGERHFVKFHWLPELGVHSLMWDEALKIAGQDPDFHRKDLEEAITSGALPKWKFAIQTIPESREHEFDFDILDATKIWPEELVPLQVIGEMVLNRTVDEFFPETEQAAFCTSHVVPGIGFSDDPLLQGRNFSYFDTQITRLGVNWQELPINRPVCPVLNNQRDGQMRHKITKGQINYWPNRLEIGRPVPTSDGGYADFAQRVAGIKQRVRGAKFQEHYKQAQLFYNSLAPHEKAHIVNAISFELSHCDDSVVYELYSKILNNIDFELAKQVAINVGGVIPEAPARENHGNATPTLSQLYYAPKVPTIVSRRIAILLADGFNLAEVEALRAALKVGGATTWIIGPRRGWVRPSGEKIGSGTGVWADHHYEGQRSTLFDAFIIPSGAEHAQSLAKNGRTIHWVREAFGHCKAIGAIGEGVAFLHEAVILPGVQLATNMKNDAVTSSYGVVTTGQYDVSSAAAHKFSIGRSEKGFVSNFAYEVSQHRCYERELDGLTAAVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7E4</accession>
    <name>A0A401G7E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bile salt-activated lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0109550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608986.1">
        <property type="nucleotide sequence ID" value="XM_027753185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7E4"/>
    <dbReference type="STRING" id="139825.A0A401G7E4"/>
    <dbReference type="GeneID" id="38774990"/>
    <dbReference type="InParanoid" id="A0A401G7E4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="173" mass="17719" checksum="AB02B78B1FBA9AF4" modified="2019-05-08" version="1">MGPSLRTPPMAVGPSLRTLPMVVGRWLYNSPSGGGPIAQNTTYGGGPIAQNTTYGVAVGPSPRNIPMVVGRWLYNSPSGGGPITQKYTYGGGPITQNTTYGGGPIAQNTTYAVGRWLYNSPSGGGPITQQYTYGGGPIAQNTTYGGGPIAQNTTYDGGPIAQNTTYGGQPMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7E7</accession>
    <name>A0A401G7E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0109820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609013.1">
        <property type="nucleotide sequence ID" value="XM_027753212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7E7"/>
    <dbReference type="GeneID" id="38775017"/>
    <dbReference type="InParanoid" id="A0A401G7E7"/>
    <dbReference type="OrthoDB" id="3178019at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="332" mass="36219" checksum="CA03CFA5F1D0F85A" modified="2019-05-08" version="1">MHLSFFPTLGSSTSLALPPRTDGRLIFQAKFLSREEYDQAQRDGIRIELWANLPSEGSGSEAWGSWLFQKIDPGAPSIIGSTVDSTVLLSDSDEATPLAQEHVLYLQVPVRLQSSTCSTFSFTYRLVYPSGSIHWLGEFGHNGHLSIEPRHSAVSLVDGWGEWENGTCTFKNVSSPLALVGRLNMEYGWSIWAVEQESWPIFCPTIREIPSASCVVLSPLSRLYEVIAPQPLILSASPGTSIHITSTGDILHTSGDASGYVVLRSFNALFDDAFLNDTNHSHTGGSHILSDHRAQSTYAIIASRVPRDAMPVCLTMIPLLASGLPLQAPELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7U0</accession>
    <name>A0A401G7U0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0111190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609149.1">
        <property type="nucleotide sequence ID" value="XM_027753348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7U0"/>
    <dbReference type="STRING" id="139825.A0A401G7U0"/>
    <dbReference type="GeneID" id="38775153"/>
    <dbReference type="InParanoid" id="A0A401G7U0"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="906"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="489"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="754"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1013" mass="108771" checksum="84E462E047919912" modified="2019-05-08" version="1">MAEVEVHSGDPHEDVVASSEELESLPEANEEHEATDVDKLHTEETPVNNTATEEHVEEAMDHVPAAPVADDAAGARHEDNATPEPEAPVHEGVAGVTDTEAGAAAVHAKEPISPLKAKPTVKSSVSVKPLKHVAGPPNLLVKKIINSGTFGSGAVKHAPAAASKATAPSSATSNKPTATSTLRKSVSGSAHTVKAPMPPPPSRQSSTSSASTAARRQSIVPKAPTPTSAKSPLSSSTTGRPTSAAPSATRPSATTPDPSAGPRPRASVTEGVKRVPISRASLGLTSSNRPPSTSSARPTRTPGTSSVSSIKEIKDDSSIVGELQYKLVNVTASLESKTQAIAALEGEVATLKSSLTEALAEVQDKRSRVQSLEEAEGRAEQELADVQETLSKLQTERVEDNATLEAVRLELEATKATAENQTQLVTSLQSQIESLEAEIHAAKENLDVLRASSDEASVAAAAAADVEHSALLKAHEDLAAVQGETESLKAAHIQALAEAEEKIQASSEQASRADALAAELAELKSENEEKSTKVSELEIEILELKEVQESSEDGHNKVLDRLKTLEEELTTAAAAMQEAVDGAKAMEEEYSQRLEDAAKLLDEELSKANAEHSKLSEELKALEDKHAEAVAGIDQAKADAQVAAEEHLRKLEEVEKLHQDKQAELSEEIKRITADLESQEEKYNARVDAVKAEHDQLLQEAFERAKNDAGSVHSHDLQGLRAESQATIEQLRAAHQSTIEGLEADHEAAIETQVKTLENKMSNQGLELKATQDDLAKAKAAYTVASQELESLRVQLDAARQIAAAVDQTDKDELIARLTKDIANAREERAALNDVLVATTESFSEISNNHGKELEEAAKGRAEEITKLRAAHQEEVAVLVVEKSELHTRLSDLQGELATIKAKLSAEPLASPRSNGAAHARASSVTREELQRAHEAHNLKLHDLQAEHDRSIRLMREELEIALAKADELQQEVARKAMEIQYLEQDQEENQDQITRLKEDMDHLTDQLKEHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7X3</accession>
    <name>A0A401G7X3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0111310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609161.1">
        <property type="nucleotide sequence ID" value="XM_027753360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7X3"/>
    <dbReference type="STRING" id="139825.A0A401G7X3"/>
    <dbReference type="GeneID" id="38775165"/>
    <dbReference type="InParanoid" id="A0A401G7X3"/>
    <dbReference type="OrthoDB" id="3261881at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="441" mass="49648" checksum="0ADA07EBB5EEAAE1" modified="2019-05-08" version="1">MPPRYSNSSAETTKKENARKTRAQSASEIARNVKSFETWATYQGCEEVEYNDLPAHLAVEVKNVFDVSGRLPDAWLDKSSRVHKALKKLVSAEFMEFIRSAHDASPELFTSAMSEPECRNLLCDIQSVFVAWTRLQKMRNSSRKWSEADYTANVYNVFRSPAARESDYRAQCSVSLSQPLSCFAVTSKAVRALNAKAACPDSSFFIPTRLIRELSHSARSPFKLLKAHPSVVNSGSVGGESSFRFQSTPCTKLPDTPGFEFASTFWEDKKPVHHMLDDAYRQNRMATTSAVRQLHSLHVQAPIFGLVWARGTVRAHVDWWTVKPNSDYPSIQSAAYPGANYGGRRTSDIFHEWQLDEPSDILQVYLLVRNMDHWTVNGFCERVISGIKQLATDVVENEHAFVPWKRKGDLGRSIPTNIPRNPVPAATPSPPRRKPGGRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G890</accession>
    <name>A0A401G890_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0112520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609280.1">
        <property type="nucleotide sequence ID" value="XM_027753479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G890"/>
    <dbReference type="STRING" id="139825.A0A401G890"/>
    <dbReference type="GeneID" id="38775284"/>
    <dbReference type="InParanoid" id="A0A401G890"/>
    <dbReference type="OrthoDB" id="3070852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12784" checksum="DED92444D86E4471" modified="2019-05-08" version="1">MSNDSASEPPSSVVSFGSYADLHTSASSSTSCSSVDFGYNPFTSYGLLLGSGNQVWHPPMLPPDQSPRFIHPPMLPPDQSPCFIHPPMLLPDESSGMFLHPPKLHQDDTDTIRAQLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8C0</accession>
    <name>A0A401G8C0_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0113020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609327.1">
        <property type="nucleotide sequence ID" value="XM_027753526.1"/>
    </dbReference>
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    <dbReference type="STRING" id="139825.A0A401G8C0"/>
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    <dbReference type="InParanoid" id="A0A401G8C0"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="294" mass="33939" checksum="0AA2113AA3270E58" modified="2019-05-08" version="1">MQISRTVIDCDHKRFSLTNYFCRSPVRRSPQSHSRAPSALPASGSALEGLALRPDKPVIAVDLDDVLSQTNRVVAEWHNDTYGSNMTLAHFYYYYYWKNPFWGAPEETFRKVEEFYRTTRLDEAPPVEGALESLKKLIGRGFQLVVVTARQQREMERSMRWLQRHYPGIFETMICTGQSQETLADEHEALTKLSKAQVCHKLCAKFIVDDSIENAHKCARANPPVPVLLFGDNSWNQREAKFGDMKDELSFDEKLELEGGREFWRDDLATIPEGITRVKNWHAVVQWVDENIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8E8</accession>
    <name>A0A401G8E8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0113450</name>
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    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027753568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8E8"/>
    <dbReference type="GeneID" id="38775373"/>
    <dbReference type="InParanoid" id="A0A401G8E8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="66" mass="7543" checksum="760D3BED28B232E8" modified="2019-05-08" version="1">MRHSSKSLCLSSSSRSTNPKSNVTVANCGNLFKLSSIASQSNRLQETWERIWMYAVHSMGFRELQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8I3</accession>
    <name>A0A401G8I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0113750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609399.1">
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8I3"/>
    <dbReference type="GeneID" id="38775403"/>
    <dbReference type="InParanoid" id="A0A401G8I3"/>
    <dbReference type="OrthoDB" id="2803610at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="92" mass="10493" checksum="9728AFAC62B4B198" modified="2019-05-08" version="1">MPSLSFFKVSRKTKRSSMDSRSSVDLRSSVDVPRPSMSSQGSSQSYLVSLPTQPMQIPQVRFASAEYLSCRPTAEMLDDDNMAWGSRRKWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8W7</accession>
    <name>A0A401G8W7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0115090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609533.1">
        <property type="nucleotide sequence ID" value="XM_027753732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38775537"/>
    <dbReference type="InParanoid" id="A0A401G8W7"/>
    <dbReference type="OrthoDB" id="2742726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="680"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2302" mass="256831" checksum="D5B3FED2FBE4A2A0" modified="2019-05-08" version="1">MSSSNLPPPPERPPVGYDREESPPIVEEGVEEPYVGVELFVSGLPHATIYSASHHLQEMLRELEPTHPITRYFVVRLADSRHACDYAYIALDPALARHPRPDLLEQLRGILDNIPGIHATWRVATGPDRTRRVVFPMDNKDQATRMLDRVREWLTDRGHEYQLSYASCPSGAWRLTFDLLDSEVVQSLLINPPVIDRHALTVSRPRFITPIYGLEVAVMGLQDLQGVRARIDRFIYQRYGQGALICSRMAMNGDVYTAVLRDWEVTSHFTSDPFDLFTDHPLSRIVSASRPLLLFLLNTYGVPANAAVIQGQALSSADSRNHQAQLDALRQQGTEAVRMYNEMFQRQQRMLDTLAVNSNQIMSTLTSIATTSSLNCRLIGAQSTLSGLRERHDLMQDVLVFTPEQTRPVLAQRIQGIEHRIDEEKETVAKIQLSLEKHEAHTFSLLPPGDTSAPGPLPLGPPRSQSPPPRALSPSAPPSVPIPATAPTPPVSSASFPLSLPTQQMPPSRLPTDLPHKRPFPDDDDYLNPPSRRQHDDDDRMDELVRSPQCMYTSCGSLTPPRSEETDRSQSSVSLSLQSPHLRQKPRSAQVECTSISSSCLSFNDSLSPSCLIDTASLPPHLINYLLFVFSTTCDWIVSLLYFLSLLPFLLLHLRGSSRFLIVLLFTFLFVIPAVTAASTFNIFAVNANGLANVSKQAAIASVISSQRPHAWVINETKSSSPLASRIRAGDYTTHESLGVPVGAHSHHGKWGVIVGVRKVLHTKRVTTHDSLQGRAVALDIVIPTTSGHGFTHRLIAIYAPWDPGGSETDNAFWSRIADLCSTAPFSWTVVGDCNATLTLSESSSANLRISAASSQYRTFLNTSHGVDLWSQRDDADASSMYTFHSNNGLSIIDRVAHSSVGILTGLVQTSNVFVPATDHRPITASLALSPPPRFGPTSSTKIPSLLPYTEFPARFLYPKRSEKHRFDTFAETVDRLVRECDLHNIPITDESSFQLRYQSFTEILHSAAQCAFDVPHRHSSGDARRVSNPDIRQVMLELRRIGRLIYATRQHSLQHLAQAHTWVHTYLDDFYSTSNPSSDVPFHTAFLTFLTATRKALHRVRYHLEHLELHRRAVQSGRARINAVLLGGSSKRLYPHAHEISGPPLAITDPQQGDAFITDPQMVKDATTSYFRHLFSRRPRQYPEPDKPWLNTPSVLQIRERTASDPFSWPSPMTLLTLRSTLRKGKPRPAPGPDQWEKWMVKALHDFSLAIVLDLLNYEISTSSIPSCVKPCTLSTIYKCGVPSDLVNYRGVCCNNFLLNTPFAWLNSLLVPYLAKHSVLPYGQVATQPGVQARDLTSFLAHLEAWSNRTSTPVYILRRDQTKGFDHLEPQGFYDAVHAYGLPPSLITFDQSAQTDVPYRVKTAYGLTAPIVISGVTKQGGPLSGLKSTLTTSMGNHWLTDSVHRRTDVVRVTTCHNRLAEHHTPLDSSLLKPVMVEATDDSAILSRSALGLQASCLMMERFQATYGWFTNWVKSLVTILNVLSPPPTLSFPSVLPDRPHSGDVVYHTLPVSTSHFEFLRTSINDPDHQYRRILDIVSSFQLPTLTIRLPITVIRRIFVQCLIARIRPLLSFQPISRTHALDIDHQIAHRVHDYFHFPFHFNSSLLTTPLDQFGFDFPSVSHLNDALAVSGLLRDLNHHVPAFRVMAQITLADWTCLINGCRDPLQDPSADSLFLHQRHHLPFSCILAHSVLADQHISIRDTDQSFLFHNHVSLQHLSRAITPRSSHPLSHYLIRSLSSIGLTSLAQLGQWSLRPDTDASFQANDLVDRVTASSPTVNKYWTLLKTWLTNLPFSRFVSLLTSSNCHSLYIPDFSSWTLALPRPVRQRNAHETLRALALASPHHLTTPSASLLASDASMIPANPSFRCPRMVNFAAVNHTSSLVASLASFRASSTTTHGEIYGMITALITAQPPVGTSPPRDPSLSSPTLTPMLVTDHLNSVRLINDSLEAPLLPHQWSSLPARSLYRWLRDILLHTTHRSPVVHAPAHTTSTSPTSLANRSADTLASASQRFLLPPPPAPLPTFFMDRYTLYSPIDGYIESNIPSYITQAIVYTDCSRAASRPYHTLSLALYDNHCPPDHPYTRASSAFSALVQLYARSAQLDTALARFHRFGNISPRCHFGCDALETAHHVFVICPVFAPHREHARTDTLTETSGILTTAAAPDDLSVQILSSARILFTDHDMWPLYHARYFLGVLPPLPEGETLPRRRLLLRIAHCWHRACIFLAGRIWAEYKRRLHPDRSTTAASTIALPPRLHHLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G936</accession>
    <name>A0A401G936_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="7">3.4.21.92</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0115870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609609.1">
        <property type="nucleotide sequence ID" value="XM_027753808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G936"/>
    <dbReference type="STRING" id="139825.A0A401G936"/>
    <dbReference type="GeneID" id="38775613"/>
    <dbReference type="InParanoid" id="A0A401G936"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001368">
        <property type="entry name" value="PRK00277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF11">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="248" mass="27039" checksum="720E7B9003556A64" modified="2019-05-08" version="1">MASPGRILRSLASTYRPGSQRIITSSRKFHPLAANWTAPPSSSLVPIVIEKTGRGERSYDIFSRLLRERVIMLYGPIRDTDSALIVAQLLFLEAEETSKPIHLYINSPGGSVTAGLAIYDTMQYVSSPIHTYCVGQACSMGSLLLAAGEKGKRHALPHATIMIHQPSGGASGQASDIAIHAKEILRVRELLTSIYQRHCGKDGEDVQDGMARFGKALERDYFMTANEALEFGIVDSVLAKRPKLDSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9M2</accession>
    <name>A0A401G9M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609778.1">
        <property type="nucleotide sequence ID" value="XM_027753977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9M2"/>
    <dbReference type="GeneID" id="38775782"/>
    <dbReference type="InParanoid" id="A0A401G9M2"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7520" checksum="FF0A047312EED52E" modified="2019-05-08" version="1">MSLLLFASGLPTAEKPQARKFYLLSHPLPGSEEDHSSATRRTVESNIEDDSSTTPVARLAENSAWEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9M6</accession>
    <name>A0A401G9M6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609783.1">
        <property type="nucleotide sequence ID" value="XM_027753982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9M6"/>
    <dbReference type="GeneID" id="38775787"/>
    <dbReference type="InParanoid" id="A0A401G9M6"/>
    <dbReference type="OrthoDB" id="2910790at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="65"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="192" mass="21979" checksum="D391D127F5172271" modified="2019-05-08" version="1">MINKTLPFFLEDRTGVFTGSDFDDIYDRLFLRASRSSEKTAQSADETIMIYNMGRRSSSQRDYRPTQREPAIVLEFGPQGALWRISFTGSSISMPMGQYLKKTSMFGGSLSRKFRGSDGEEYKWTYKSVQDQEWTCVDSRNYLVAHYDLKPPEKPAYRTSGNILTIYEAYADLSVEILASLTIMRHIAANNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9T1</accession>
    <name>A0A401G9T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0201220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609838.1">
        <property type="nucleotide sequence ID" value="XM_027754037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9T1"/>
    <dbReference type="GeneID" id="38775842"/>
    <dbReference type="InParanoid" id="A0A401G9T1"/>
    <dbReference type="OrthoDB" id="2758729at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="414" mass="45151" checksum="3D27014F57A289E5" modified="2019-05-08" version="1">MASAFDILGLVFGILGFLSSVPVFYAIILSQLPSQKLKELDEVLLETETMWRRSLREGLFAGKPFERKTSLSLYSLRNQTESLRLQAHCATSLLQECKAMLRGLSWSISYVCMESKGARAEISSTTAEERKRLQVKAKLEESLRETAQIQPEMPMASDTSDKYSKQHLYTDEHAADKLFLSPSPTFGKASATLKMDSDKTPWEARVVTWNSPHSTTTFPTHSHFPSGAAPCALITSTAAVSACTSTSDKVTHRQRSKTHTSSSHTASSESVDVIAPQKVTHHPSNANTSICRSTASPVSLPSPAAQGGKFVVPLPSSNTALLQHFHEVKQEMLTRGLAFYTCTSVNAIRMVPWKKHSASARSGECVAGRSITDADMQVLSCTEGDCGVEAFKIRECTDEGLLCIVEARDVSGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAA3</accession>
    <name>A0A401GAA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0203130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610029.1">
        <property type="nucleotide sequence ID" value="XM_027754228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAA3"/>
    <dbReference type="STRING" id="139825.A0A401GAA3"/>
    <dbReference type="GeneID" id="38776033"/>
    <dbReference type="InParanoid" id="A0A401GAA3"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="5">
        <location>
            <begin position="301"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="580" mass="63358" checksum="E653D593EFA3DA0C" modified="2019-05-08" version="1">MASAIPASYYIGVDVGTGSVRAGLVKQDGTLVASFTEPTATYRDPDDHRIFEQSTNNVWAGMCKAIKAVLEEANVSSSVVKGVGFDATCSLAVADMNGEPVVVTKGDQLGEIGDRNIILWADHRAETEADLINSTGSKVLDYVGGTMSLEMEIPKTLWLKHHMKPERFARCQFFDLPDFLTYRATSDSTRSCCSVTCKCSFVPMSGWQADFFQKIGLAEFPKDNYTQLGGADMNVLTAGLPVGRGLSKKSAEEMGLLEGTSVGSGVIDAYAGWLGTIAARFKENGELSPIVPSLDESSHRLAAVAGTSTCHIVQSREGVFVNGVWGPYKDAVFPGFWMNEGGQSSTGQLIDFMITTHPAYPRLKELAQQQNIDIHEVLHDELEKLRMEAGAENWTELTKDMHFYPDLHGNRSPIADPRMRGSLMGLALDDGLSDLARKFNLTLEAIALQTRHIVDEMNAKGHKITSIYMSGGQAKNLMLMQLFANTCSMPVVLPQSSGAAVVLGAAMLGRFAAMDHTKMNAEAQGKALWDTMVEMTPAGTMITPAADPKEKKLLEAKYKIFRETIEIQKRWRKQMEEASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAH8</accession>
    <name>A0A401GAH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0203300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610046.1">
        <property type="nucleotide sequence ID" value="XM_027754245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAH8"/>
    <dbReference type="FunCoup" id="A0A401GAH8">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAH8"/>
    <dbReference type="GeneID" id="38776050"/>
    <dbReference type="InParanoid" id="A0A401GAH8"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="237"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="528" mass="57119" checksum="FAA639AFDFF6B006" modified="2019-05-08" version="1">MAPTSAVYSASADTNRKILDNIESQFRLDPDALKQITRQFLQDIRLGLGEYNHPMAMIPTFVTGVPDGTETGTFLALDLGGTNLRVCEVRLLGNKNFSLRQQKYRVSETLKTGEATALFDYLADSVDSFLTEFTGGDSPTEMSFTEEQPSASLIPPQTAIPLGLTFSFPVEQTALNQGKILTWTKGFSAKNAVGHDVVRLLQDAFDRKHLHVKCVALVNDTVGALLSRAYTTGGCVLGSIFGTGTNGAYVEKVHNITKLGDSPARAKGGDMIVNTEWGAFNNTRTALPSTPYDNKLDRESINPRLQAFEKFISGMYLGEITRNVLLSLIDAAPRPLLFNGKSSDVLNAHYGLDTAVMSEVEEAWETGRPSKGAAPTANGAVFSEHFIDIDALSAEDVARLERIRGIVSQRLSLSPADVSLRDAAIVRWASFLVADRAAKLSGCAIAALLAQTGRAELSSDFVPEEERIPVGVDGSLIQFYPNFNAHLRESLRSLVGEEVERRVEIGMARDGSGVGAALCALQAIKQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAP7</accession>
    <name>A0A401GAP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial protein pet191 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0204320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610148.1">
        <property type="nucleotide sequence ID" value="XM_027754347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAP7"/>
    <dbReference type="FunCoup" id="A0A401GAP7">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAP7"/>
    <dbReference type="GeneID" id="38776152"/>
    <dbReference type="InParanoid" id="A0A401GAP7"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="85" mass="9696" checksum="E9BF5B2BDDE0072C" modified="2019-05-08" version="1">MSSSCENLRAALKECLLYSDCVVKQGHLPSECLREHTNELPEQCQALRLATFECKRGMLDMRKRFRGNNVNAPVFTPSHPTEDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB31</accession>
    <name>A0A401GB31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610256.1">
        <property type="nucleotide sequence ID" value="XM_027754455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB31"/>
    <dbReference type="GeneID" id="38776260"/>
    <dbReference type="InParanoid" id="A0A401GB31"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="53" mass="5752" checksum="2F3CD97517D2B37E" modified="2019-05-08" version="1">MRVPVLTPTSAPTLSPLGHPPRSQRRTTTRLHDRAPTRPAARACDAPAGPERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBN6</accession>
    <name>A0A401GBN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0207880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610501.1">
        <property type="nucleotide sequence ID" value="XM_027754700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBN6"/>
    <dbReference type="FunCoup" id="A0A401GBN6">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBN6"/>
    <dbReference type="GeneID" id="38776505"/>
    <dbReference type="InParanoid" id="A0A401GBN6"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="12">
        <location>
            <begin position="164"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="343" mass="37784" checksum="5862A190B52A345A" modified="2019-05-08" version="1">MEQIAIPFECPDQGVLRKQKILLKCSLRTHAGFERCTSFAAPIMSLPPSDVTHAALVSQSLRKLQANEHVSDGIDPHAGDEPSTPGGNGEHDHTSSPGRLNPHVREGYGFRPSSGVSTPNIPSSSFESGSPLPDPNGLGWPAKSTLYRLNATPAQRVEREQKLAAAVRTILDCIGEDPNREGLARTPERYAQALMWMTRGYEERLADIINDAIFAEDHDEMVIVRDIDISSLCEHHLVPFMGKVAIAYIPNNLVLGLSKLARIAETFSRRLQVQERLTKQIALAVQEAIKPRGVAVVMEATHLCMTMRGVQKPGSMTVTSCMLGCFRTQQKTREEFLTLIKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBZ6</accession>
    <name>A0A401GBZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0209090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610621.1">
        <property type="nucleotide sequence ID" value="XM_027754820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBZ6"/>
    <dbReference type="FunCoup" id="A0A401GBZ6">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBZ6"/>
    <dbReference type="GeneID" id="38776625"/>
    <dbReference type="InParanoid" id="A0A401GBZ6"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="42"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="373" mass="40682" checksum="28206E196B23F7F0" modified="2019-05-08" version="1">MFRNTLAEAARPVLHARTATTLSAGFPRVTHRLPTKYGGVYTVTLIPGDGIGNEITDSVKEIFEHVNAPIEWEQYNVSGMSSSGEELFKQAMESLRRNRVGLKGILFTPISQSGHISWNVAMRQQLDIYASVVLCKSLPGFPTRHSNVDFAIIRENTEGEYSGLEHQSYPGVVESLKVSTRAKAERITRFAFDFALKNNRKKVTCVHKANIMKLGDGLFLNTFRRVAEEYKTTGIEFNDMIVDNTSMQLVARPTQFDVMVMPNLYGAIVSNIGAALVGGPGIVPGCNVGRDYALFEPGCRHVAKDIMGTNRANPAAMILSATMMLRHLGLDGLANNIASATFDVINSGKVRTADMGGSATTSEFTAAIVKNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCI0</accession>
    <name>A0A401GCI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0210810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610792.1">
        <property type="nucleotide sequence ID" value="XM_027754991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCI0"/>
    <dbReference type="GeneID" id="38776796"/>
    <dbReference type="InParanoid" id="A0A401GCI0"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="382"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="815" mass="88906" checksum="955F7AD66B34CBBA" modified="2019-05-08" version="1">MASLIDLITSVALLIYMLFAYASEYLAPQFSTVSGFATIMIYGSDMIAASCSLLIPVSLVAIAVSCYPSLRLTAYLAAVPVSYLAHLLQDASAVYIASFASSIPGSSFSTSKSNSSATFVRTAILIRTAILIGTFHMISDWYETHGCDIAPIDNLDINRAVTAASAFVGKALDRIVANWTATRLRTGQDAALVAALQDALHDAQKTIKERDEIIQEFDAAVHGLEARLESLCPSVDEKSHELAERADAIHGLTSKAATAKTALVGLGARVENQAAAILDVTDQLTWARQDIADAESAIIESNARITSLTADLASAHRATADAQKKLSAQDTLVADLNETLDLACESLHEKNQLVKERDKEIGGLNDTLDLACETIHGKNHLVKQRDAEILKLRRQLDEQNAQLVTHARIVEELAAAKDDAKRLQAMVDRRDTELKQKTRALAVCTDQLTDVNRDLQQCETLARMEKSELESHTRSLQNRVDALQAQLSLKVLEIRALADDCTDLEACLEESASTVSRFLRVRNEPSAGPMRSLRARLRWLCRDSQRLLEQDVVIDDDGGDSLNNALQEWNDLLEKAGLVSTTSWEDAWLDDAVEPQPESTITSAAPPSPMVDDGLAVRLRVTCHHLVQERARTEELRTQLDNQGSRLAMCRTALLLASDDLRRLRVIAHSARMSPNADGLAASLAECNAQIATLIFTKDSLELQMADLRADVYATRARNQTLEAELEDQGSRLKLCQAALRLNSEKRKSSKRKMSAAPESAVKMRSEPVLCEAIPSALQSPSAMSTRAPLSALSVNVTSHTNLSADRRSNLAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCL7</accession>
    <name>A0A401GCL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0211300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610841.1">
        <property type="nucleotide sequence ID" value="XM_027755040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCL7"/>
    <dbReference type="FunCoup" id="A0A401GCL7">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCL7"/>
    <dbReference type="GeneID" id="38776845"/>
    <dbReference type="InParanoid" id="A0A401GCL7"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="268"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="499" mass="55060" checksum="5A958346C82A35B2" modified="2019-05-08" version="1">MTIHHGELEGGVSDEALLDLLTAPTFPVAKHGTKRRDSELDPLLLAAAAASGPHVTRNHYAHDFFPAVGDPRAEGAWDWTKWRGDDALSRQERKPRLKYVSRQKPRRQRLRELGIEANEEKENGPAREATDPLRCAGNLPPSVPKASSSSTSTAVSSPATVPSPDASRSVPATPAIEVKCMARTRVPTPHGPVFLHLYHNNRDNKEHLAIVVDPAQFLEDIPHRAPPIRSRSLDAVWSESETEVERITRGAYVGRLSQTSQVPSTPWEHTNQMTDNVPSPLVRIHSECFTGETIGSMRCDCGEQLDEAIRLISQPITIPSSSPALPPVVIPGRGVVVYLRQEGRGIGLLSKIRAYNLQDLGHDTVTANLMLGHKADERGYEIAGAIMRDLRMGTERGEGVRLLTNNPDKVHALEQEGIRVVERVPMVPRSWQRRQAKYAAQRNAIDIAVSLGMEDPHVHGLTMIGGGEVYGEDLDKYLRTKVLRMGHMLPLLPQDPDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCM6</accession>
    <name>A0A401GCM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0211400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610851.1">
        <property type="nucleotide sequence ID" value="XM_027755050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCM6"/>
    <dbReference type="GeneID" id="38776855"/>
    <dbReference type="InParanoid" id="A0A401GCM6"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="108"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="643" mass="70385" checksum="71C7D8D0A29A41EC" modified="2019-05-08" version="1">MTDSVTISLLPVSLSLVHLPRSRLETLSQHVLRQILQPSPIFLNVTCNEIELSLFAERHALKDFEKIARKDAQKLRSRRREEGGETHPTQDHKRSKRQKEDWEPVEVSSDKWNVLQIDSHSDRLDTSGARVHELSAPLAAAGISILYQSSYMCDFIFVKSYRLSEVMSLLASAGFDLYSSDPYNLTAQLSTFTSPMLSPTREDISSINILDLATAQVQRHGIDPEGGAVFSRSRSNTNSSSSSSGGRTVPQNLHVSSQRDFEDDSPANQVPERPDAKQERAAQSRSQSHSPSGCEVRVLEPDLTYVGLSDDSVEMWGLKIVKLVAFPELIVPVRRGSGGESSSSAASHGRHVSPSPEHPALDQVPEPVHLPTIGLSDDVDAVPFHINVASDGEKGNGSGSDTTTRVGPDSPKGDPAFDMSPVSPLFETRNGKVWEDVFDLEDSSDEEDHRSKSPSEEAHKRETSEVLAAAGQTRPFLPHLETLKPAHDHSRSASTSSTSSAVSTPPLLVPFFSFTRTSEGSSLTAPVSLLAALFPPSERHMVICSDELDILDSRVSSPITPEGPEVGESEDHDDERNGAQGPLRCLQIDLRKFGLDKHGLVNRYSRTLEENGINHMYSSTYKTANLLVDKAHASRAQALLRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD21</accession>
    <name>A0A401GD21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0212520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610963.1">
        <property type="nucleotide sequence ID" value="XM_027755162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD21"/>
    <dbReference type="GeneID" id="38776967"/>
    <dbReference type="InParanoid" id="A0A401GD21"/>
    <dbReference type="OrthoDB" id="19861at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="108" mass="12109" checksum="51CB0FD20199DE89" modified="2019-05-08" version="1">MFAPSERSVERDGTLSAHDLDEEIPATCQLIIAHPLVGLDVENVVVRNEYVEALQDCTVLCQTRPWGNEVIVGHSGIGKTIFLYYVLAYRLRSRLPAFYQNTADSVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD59</accession>
    <name>A0A401GD59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0213210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611031.1">
        <property type="nucleotide sequence ID" value="XM_027755230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD59"/>
    <dbReference type="GeneID" id="38777035"/>
    <dbReference type="InParanoid" id="A0A401GD59"/>
    <dbReference type="OrthoDB" id="2751422at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="48314" checksum="FBC19BAA7D59BCEC" modified="2019-05-08" version="1">MAQPLPAISNVPPEVHNLFIDELRDDKASLVSCALVCRAWNPYSRRHLFHSICVIEKEHRNVAAFLKLLNSSADVHPHIHALTLRAWPPVPMDPIYWRCGTREASKPSIPLDLHVLATILSNLPNLQTLRLLEFAYTYAPEYGLPQTAFKIEELSVRQTPRQRECSFKTLGVLALFAEVDRLCLEDGSRHDCDPRNDFTRRPEHELLSMPKPRVHNLTFGWIQEMDYYWRYLLPSSSSSTLTGLGAVFKHSKDFGAFGTVLCKARHSIRSVELRITSSFIAKNLKAKCFGIDLSKCPSLESLVLGLNLVGENNPLWPVYTHLLRHAPHTLREIIVRVSVMWLYSTSKFFAALQSLDGAAMDKVLGVREELRAVKFEFTWDDREKNIPVHTAPHPDVDSYLVTACRDILQEMLPTIHARGLLRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDL6</accession>
    <name>A0A401GDL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0214720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611170.1">
        <property type="nucleotide sequence ID" value="XM_027755369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDL6"/>
    <dbReference type="GeneID" id="38777174"/>
    <dbReference type="InParanoid" id="A0A401GDL6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8723" checksum="144DD0B6CFD7C549" modified="2019-05-08" version="1">MLIHTLSVYQTNLTSLDEHLPPAACISLARQPSLSLANGPLRRLPLQLPSVHLTVLKFTSPRRGYAFFTIRPLSAIMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDW4</accession>
    <name>A0A401GDW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0300890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611287.1">
        <property type="nucleotide sequence ID" value="XM_027755486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDW4"/>
    <dbReference type="STRING" id="139825.A0A401GDW4"/>
    <dbReference type="GeneID" id="38777291"/>
    <dbReference type="InParanoid" id="A0A401GDW4"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="502"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="748" mass="82910" checksum="6D63FE35FABEF506" modified="2019-05-08" version="1">MAIENVPEKVDAEALQNGGIGPPKSGAILEVKYLHEALDGFGFKYTAEPPYRSQPQDLCEQQTGSDYTVYAFVVINCLKSSAGGQTVPDGTTILQVNSTHLINIGKDVIGEGQGVSWTSSPVRVEPQLLLSFLSELQQYAKELNEKSIAEDGSSLCTKCAHLSHLLDFLKAAYSSTIETLSSLLAHGEVSFDFLWALYVPRKTLLYLPCPVTGEPRAARLVQAELCEKSDDQEFPPPIVHQPTSHSSAKKDLKYWRLALEYVEADVGMVGVPMGELGSGTGMQQGNLEPRFGLAMLNVRLEVHAFKGTQKISSLLAYPICYYTGPGGESGLMNRLLARGRKWVAVAGGMHHKAYRGLAFRYSYKAGGYVKMNVDSRIIADRKRFQDLVPHYKLPIVTKAMCGHRIDKFAVRAGAIANSLSPVVDLTEMDLLLTSPIIYGFSLSDKQWLEFIIDYASDIEWNDEAYDHLVIPIDHKIVLKTLVQSYSTGAMSKFDDFVAGKGLGLVINLYGSPGTGKSMTAEGISEYLHKPLYVVGVAELGTTAEVLDFNLSAVLKAAAAWGAVVLLDEADVFLEERSLQYLERNAMVAVFLRRLEYFTGILFLTTNRVRVFDEAFQSRIHLSLHYHDLLPDAREHIWTAFMKKINGNVPRGGLTQEELRELCQKNVNGRQIKNVVRTGGAIAASKQEPVSYQHLSRVLDLMEQFHPIYVSVEDFWTFAYTFHPCEPSGKAVQPHIFALEGSRSFNLMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDZ0</accession>
    <name>A0A401GDZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611309.1">
        <property type="nucleotide sequence ID" value="XM_027755508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDZ0"/>
    <dbReference type="GeneID" id="38777313"/>
    <dbReference type="InParanoid" id="A0A401GDZ0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="809" mass="89677" checksum="E800220DB912A4C3" modified="2019-05-08" version="1">MEHQPILSEKLQSYDMADAKGRKTLVQSLCQKLKTHFVDASNYDDIIVETEKVTKKCMHVSGKPNAFKVWDALERDKVTEAMRALMVEKGCNVSKEEQKAYEEKVESWQNGTLDDKMKMKLREQRMMQYLKKFAKTMWDTMGVRMAFMLAYPKEVGSLKVEMVEVNHAITNGTPFGAYPGWLCAYQPPAKVFSEWAKGEYGVTETMVMVKKTPANCMRAMDKIRLMANGFPLLPSVPEGMVEAPLKVMKVQVRDFMNHHYALAKGVRNCKSPWTKLNSIDDINEVIVAEMLPENFQWINPSKLTSVPIRALLDHCTSTRMAKLLSPKALTPKKAGKVKKKGKSVRKVTGKVASKATKGKAAPGGAKGGGCKCKMKDAYNSEDDSRSSQDSHRSSPDIPSMGSEEDLASDEDSEDGESIIAEPHIVKRRDVFLAMLSVKLRYQDMLKQVKIATVPQVYRFARYDPIPWSEWSYGQRYLPPSFHAVDNFDIVENWLGDKPWLTKYRFLHPQGVQQSALVIGMVLRDLTRSQFIEEGEPTNLSDYVVNSAISFDAVEQLLRCCEIITLDMVEGNVTHAMVKPVSKPAIRSAPQGGDGLGGQEEQEGDASARTHNGAATAAKVYKAHQPAAMANNPIIPSGGDEGLSQETSGGASDDDEEDNAHLSIPSSGAERPPPPPFIPKMRKVAATEGHPSGQAKVLQGRSITDALQSNIPSRITRSQCQAMDESPTKNTRSQHPLGAVKDLKKLSDPKRKCQPAHPEPDGEDSSGEDNLPPRKRGRDTRDELVVASPRKKNARAEDSDDGDKPPAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE25</accession>
    <name>A0A401GE25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable Xaa-Pro aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0301440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611342.1">
        <property type="nucleotide sequence ID" value="XM_027755541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE25"/>
    <dbReference type="STRING" id="139825.A0A401GE25"/>
    <dbReference type="GeneID" id="38777346"/>
    <dbReference type="InParanoid" id="A0A401GE25"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="8">
        <location>
            <begin position="268"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="7">
        <location>
            <begin position="587"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="9">
        <location>
            <begin position="811"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE80429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="887" mass="101083" checksum="B2028AAAD2E9E0D9" modified="2019-05-08" version="1">MAPPPPPPPPPPPLCLPFSLGGKKPRRRLTYSEKSETDAFSSQRSSIDRLERHDSESYNVPSFHNEAREVRPVLRRATTTKRTTKGAPAVPPKDATIKRRWPYGYGWGIGKKNKEKEEMAREEEDVVSDEDVNSLWRTDDVPAPQYQSPHNSNRSKHSKQSSHHSKPETASKHSYNSGSIHYMNPTIPPATRSPSDHIYSNPLPPAGTNSRSNTFKSNITKSSGNSRDKSRRPRLYPSESSSTLVGSLLERKVNDNDPIPPRLDSTGRLEALRELMRKENLDYYVVPTEDAHGSEYVAVNDKRREWISGFTGSAGQAVISQTNAYLIADSRYWIQAREQIDRNWELVKAGAPRQPADWVEWIASLRDEVRIGIDARMIPHETASKLNSILQPKKSKLVYPPQNLVDLIWREKPSRSRNPIFVQTIEFSGREASAKLSEVRRWIREQPPSVPSYSKSEPKPSQMQVGMLLSNLSDIAYLLNLRGDDIPFNPVFHSYLFVGFDTTVLFIEQAKITEAVESYLESIAVERRDYNDLWTFLRRKQWGEGKIIISPKTSYAISLMLTSFNYTVLEPYVEHMKSIKNQTELDGLRRAYLRDGAAFVRWFAWLEHKMGQGYDITEYEAAWRLTEFRRLNKHYMGLAYENISASGPNAALPHYSPRKATARMIDRNTPYLNDSGGQYRDGTCDTTRTVHFGRPSEEQCVAYTRVLQGHIAIDSAIFPAGTSGTQLDVLARKTLWQDGMNYGHGTGHGVGAFLNVHEGPQGFSSTTPFVPGHVLTNEPGIYKEGHWGMRIESALFVKKVRTKNERPGDTWLGFERLTCVPIQTRMVKDEMLTRDERQWLKIHNRRCYELLEPYLRDDKRALKWLQREAERGIGLAKAPAGISIDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEI1</accession>
    <name>A0A401GEI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0303070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611505.1">
        <property type="nucleotide sequence ID" value="XM_027755704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEI1"/>
    <dbReference type="FunCoup" id="A0A401GEI1">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEI1"/>
    <dbReference type="GeneID" id="38777509"/>
    <dbReference type="InParanoid" id="A0A401GEI1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="28345" checksum="5EAE3D2AE6CC123E" modified="2019-05-08" version="1">MARRYDSRTTIFSPEGRLYQIEYAMEAISHAGTVLAVLAKDGVVLAAEKKVTGKLLDLSLAKDGGYGGSGEKIFLLNANVVAGVAGITADANSLVNFARQAAQKHLFLYNEDIPVELLAQRLCDLKQGYTQYGGLRPFGVSLLYAGYDPHYQFQLYHSDPSGNYSGWKATCIGANNGTAQSLLKQEYKDDMSVEDAVGLVLRTMSKTMDSTTLGSEKLEFATLTLDASKQPKAKIYKPAEIDALLQKHDLAKKDEDTEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEL6</accession>
    <name>A0A401GEL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0303310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611529.1">
        <property type="nucleotide sequence ID" value="XM_027755728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEL6"/>
    <dbReference type="STRING" id="139825.A0A401GEL6"/>
    <dbReference type="GeneID" id="38777533"/>
    <dbReference type="InParanoid" id="A0A401GEL6"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="59"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="531"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="905" mass="101125" checksum="5A9C60DBC23E8396" modified="2019-05-08" version="1">MPSTTSTDPSNSRDPFELERLAQELEAREARKDRSRNPGSSVEELSAAERDLPIYIPLSHDNPYLTAGTFNVEDFLLSRAYTSLPDLRAELRDYLATLKEELVRLINDDYEAFISLSTDLRGEGARLERLKSPLGDIKAQVLEARQILQVIQDAILLRLNQRATLREEKAFLHLLLKISESITRLESLLLITSPADEKQNPELNGMGLSHAEDDSIEERTRGNRAKHLARVAAEYTQLLYHVSRASAERCAFVDESQWRVDRIRSTLSSDLDHLFASTVIALTSGKESRKEIKATELEKSKWISDVTECLRTYDVLGLWRDAEDVLRKEVVREFVKKTVHPGALASPHSPLLPHTPSAAGMRSAAPPHYSQPARTPYTPFSAFASKQNPFSFNLPQGTVAPHALDEHDDPLAVLYNAVLRFVDRDLKRIMEIAESVCVRSGARTSPLLGAAPVRAQESRGFEIMANVVWAEVGRAVVDELGSVVFAAGKPDEFRKHHETTQAFIRALEYLAPSVHAIEAMRGHPVYATFERRWQLPVYFQLRWKEIVTKLEESLATTRLERVNNKEPFMTLQATAIWDAISTCWSAEVYIPELSYRFWKFTLQLLSRYKTWLDASLPAFEPPPKIAAAVAAEKLGNIPGSPSSQLSRATTPIPPTEAASAEATAAEDVQLQQFATAITDIHAMQTQVMKLWREELTVMLPESLGEGEDDVSPEDMLKRALAKHLALVPPLCSQIIFILGRRGCDALLSMRSIPSQFRAMSASKRAPTEPSYFVVSIFRALRAFFGVGTADGPGAALKGEYLQSFAEEVFEVVAQRYVYFLSAMKKTEESLRRLKKGKKSTFSFLGGSGATKDDDGRADEEKIRAQMILDVEAFGKDAEWLGVAVHENQTFKTLETMAHTSLADDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEN6</accession>
    <name>A0A401GEN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">SCP_0303560</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611552.1">
        <property type="nucleotide sequence ID" value="XM_027755751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEN6"/>
    <dbReference type="STRING" id="139825.A0A401GEN6"/>
    <dbReference type="GeneID" id="38777556"/>
    <dbReference type="InParanoid" id="A0A401GEN6"/>
    <dbReference type="OrthoDB" id="2797107at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0229">DNA integration</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="17" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="22" id="KW-0862">Zinc</keyword>
    <keyword evidence="22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="24">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="25">
        <location>
            <begin position="499"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="836"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="GBE80639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1218" mass="136618" checksum="E9A8CFAD1A6F312C" modified="2019-05-08" version="1">MSGERRNPWSGRSSPCRRSPTPPPLCRAYWDEPGTPTGGHRPRARPQRSGENLYAQSSPRRSAAPSRRPTLSPNAGGRRYRPLGEGGAEHWTLHKDTDHSSHMNLTKLPHKLTPTNYVSWMTTMESTLDTIELFEYATGEVPEPDPDVDEARARRWKHANACVRLILASNMTEEVVSQISHLTVAAQVWQEYYTSSEIERRLKEEYAIRQNQQSTARAYNAKQQSGKRSKKEYKPGDPFCKNCERPGHYIKDCWSKGGGAEGKGPRSKKKEKKDSEKQDVKGKERVNEVKEDSDHLSCMAAPGSSSRFTWILDGGSTTHICRTKSAFVTFTPSSETIGGIWKTGPQLEVHGRGDILILCHVHSGDQHIVTLRNVCYCPDARDNIISESRMDQKGLSIHKQNGLVAVQNSNGKVIMEGARRRDLYELDCAIAPPSSHPSEISFAAQLSPSDSELWHRRLAHIGQGSLQYMVKHALVTGLDLKSVETLGPCDGCAKGKHHQAPFPKQATNRATSILHRLHMDLQGPFDLSITGYRYTLAVVDDYSRKGWKAFLKAKNDATSEIKDLVTRLETFSDKRVKIVRSDGGGEFIGNDLQTYFKSKGIKHETSAPHTPPQNGVAERYNQTTHEHALCMLQEANMSSGFWPEAHAYASLVRNRSPTRALVESTPNEKFYGQKPDVSTLRIFGARCHVRVPPESQKKLDAHSLDGIFCGFAPNQKAYKIWIPSRHKFMVSRDVIVYENVPAMPDDDDQNPALSEGRNFRDITTTSSNSSGFGITSFSANPYTARKSAIHCISTHSRQYFRTSTNARASSRTSPTFRTCHAPILDQASCRETAGIRTGDKDTQQGDQGSTHTAETNEVPTTPEGDVTQVAYMAAFGTDTPMNFREATKCSEADNWWTAMHEEIDMLQRRGTWVLEDLPPGRKAIGNRWTYVIKRGPQGEILRYKARLVAQGFSQIPGIDFNDTFSPTVRLESLRAILHLTAAHGWHRGQDDVTGAFLHSKVDVIIYMQQPVGFDDGTGRVCRLLLSLYGLRQSSHLWNEYMDGQLSTISFHRLICDSAIYVRRTETGANSILAIHVDNTLSFSDSAEEFASVRKQLHSIFEMKEEDPNWLMGFELIDNPQEHTVSISHRQYISTILRRFKMEDCVPVPTPMESSLHLSVHDAPSTPEEIAEMKKRPYRELVGALTWISVISRPDVSFVSAHLAQFNANPGKRHWEAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEZ0</accession>
    <name>A0A401GEZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0304660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611660.1">
        <property type="nucleotide sequence ID" value="XM_027755859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEZ0"/>
    <dbReference type="STRING" id="139825.A0A401GEZ0"/>
    <dbReference type="GeneID" id="38777664"/>
    <dbReference type="InParanoid" id="A0A401GEZ0"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE80747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="382" mass="43446" checksum="C3DDE9181982E3F3" modified="2019-05-08" version="1">MLNLGQILDKFFIQVSLLLSKPHSVRPSIATLSKEDLLLEFKGSRVLIPDLYALLPGWRFNVNKHCDSVRKQLNEWMLSWVDDEKNRRRMQAADFALLAGCFYPDAEEEEYLMMAYYHLWVFVWDDELDCGPLTHDYEGAQIFRKETDDCLHYTLGPEPFKEPRPPIGPIMAPFCEVAEKVVAGSTPDARAEVLRELEGYVEGACALPGERQGEKDQKAFLSMEKFMAQRARSGGAGPSITLLLYIYHIDLPTLILEHDTLQTIFHQACLIVHLVNDIVSFVKEIRDDQLDNIVPVLAIEHSITLQEAIERACDLVRAARHSLEMAETHLPVTGSTELDGQIARYVQGCKDVAAGNLHWSYQNARYFGQNPQREGNKIFLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFF1</accession>
    <name>A0A401GFF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional activator Myb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0306390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611830.1">
        <property type="nucleotide sequence ID" value="XM_027756029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFF1"/>
    <dbReference type="STRING" id="139825.A0A401GFF1"/>
    <dbReference type="GeneID" id="38777834"/>
    <dbReference type="InParanoid" id="A0A401GFF1"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF199">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="473" mass="51279" checksum="F84A87A3C74FED14" modified="2019-05-08" version="1">MQTQDEAQPRDRRPWTEEEDEKLLAAIEEEDPDTNPPSRWHAIAQHIPNRTNKDCRKRWWAQMATVVSKGSWTNDEDERLFNAVEELGPKWALVASRVRTRNSGQCAKRWNDALNPSIDRSGWSREEDELLLKGVEEQGHSWANIARNCLPGRTGLAAKNRYNHLLRGSDRPAGSRSRRNTTIITSSRRRTRGASVSSPSSYSPASPQSYSATSRSSPEGSMPPSTPEPLTENDVGASGCTVEAGPVDRTKMKSGRMCQDTPSGSFSPPAGPAMEHQILDLFMSDAFADLSANSPTSLLDHVPPAGTPPILGDIEQYNLFGPWSDGVLGSATFTPSSFLDPMTGVSQQASSSVAPHFSGDILDLHGFQPAAAPEKADFLTSSSALHPQLRSPYVTSPPSDFPAFSDAQVTIGSVPSLPDRARIQVSQPNVDRSDRRIAVAVAICDRQDIGSTVQSLSHSLSTILTRGQGAGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG43</accession>
    <name>A0A401GG43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0308820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612069.1">
        <property type="nucleotide sequence ID" value="XM_027756268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG43"/>
    <dbReference type="STRING" id="139825.A0A401GG43"/>
    <dbReference type="GeneID" id="38778073"/>
    <dbReference type="InParanoid" id="A0A401GG43"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="201"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="335" mass="37296" checksum="D64311B9AFDB4083" modified="2019-05-08" version="1">MSSHSAIIASLSDNFERALASGDLLFFPSTVYKHNDHGIEFEIRLCTALQQKPSLPTPHFDPAAEGKPVGKAHKPDPFAPPYIPNLYLGEIRDEEDDSEYVILLNKYSVVPHHILLVTKEYKSQASPLLPAELAQIYTFLVAARQAGRHFFAFYNCGDLSGASQPHKHVQFLPIEDDGPPIERLARSTSIEVITRPFSLTTLPYANHVRRLPSNLASVPRSDLEGSLSDAFLSLLDLAISTIRHDGDYPPGSPSYNFVLTLEHMHVIPRRREHHVLQKTGDQLSVNALGFTGLLLVKSEKELDAVKMEGVGKILRDVGLESVHELQLEEFSHETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH28</accession>
    <name>A0A401GH28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0312090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612393.1">
        <property type="nucleotide sequence ID" value="XM_027756592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH28"/>
    <dbReference type="STRING" id="139825.A0A401GH28"/>
    <dbReference type="GeneID" id="38778397"/>
    <dbReference type="InParanoid" id="A0A401GH28"/>
    <dbReference type="OrthoDB" id="5594057at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02509">
        <property type="entry name" value="GDP-M1P_Guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049577">
        <property type="entry name" value="GMPP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054566">
        <property type="entry name" value="ManC/GMP-like_b-helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22640">
        <property type="entry name" value="ManC_GMP_beta-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159283">
        <property type="entry name" value="Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP isomerase/GMP-like beta-helix" evidence="3">
        <location>
            <begin position="452"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="506" mass="54464" checksum="9A125C5B8692AEF1" modified="2019-05-08" version="1">MSFFSTITTKSPMQSTGNNPQVEFMFKQILDAVQKSNIEIAEIRCECHELRQANANLERLVREGMQHVQAVVVNASQRNGHIGTKVGFQPSAPASPLLRSSRSPFLSPPLPSLSCTSSLYISSPLGDNALTAFPFGVREIPGFYVVIPAGGAGTRLWPLSREEHPKFLLDLTLKGRSLIQATWDRLLPLSSAARTTIVAGPAHVKSIMEQLPDLLAHNILCEPSAKDSMAAIGLAAAVLAQRDPDAIIGSFAADHMISGDDAFLAAVAEAVEVAKKDYLVTIGIAPSHPSTGFGYIRLGDKLGMDGAPNARLVSSFKEKPDARTAAAYIKTGIYRWNAGMFVTKATFLMQLLKEYKPELHDGLEKIAASWDDEKLRQGVLDEVWPGLEKIAIDNAVAEPAAMDRRVAVVPATFGWDDVGDFSSLAGLIPAEANQPRVLGDSGLVLTEQAAGGIVVPGSGRLVSLLGVDDLVIVDMPDTLLVTTRARSQEVKRLVKKCRDAGWKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI39</accession>
    <name>A0A401GI39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0402340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612773.1">
        <property type="nucleotide sequence ID" value="XM_027756972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI39"/>
    <dbReference type="STRING" id="139825.A0A401GI39"/>
    <dbReference type="GeneID" id="38778777"/>
    <dbReference type="InParanoid" id="A0A401GI39"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="249" mass="27890" checksum="1B7465C5411D995D" modified="2019-05-08" version="1">MATQPSSQFAALLRQSKFASFDPAIAQAYTSYGGHAYRGNFGFKRPLPVRHRNATVFVHAVDSRQQQTEWKSAEQQRRWIQMWDEVGATPHVRGGSTWSNKLGPLGEIRWQVDSEFGSSDSGVDDRGVGAALTGKSTAVANINAMPEREFERYLEKLRKMRPAFREYLKKHLEKEGRGSVPTTLWEQSIKPRTDEYLKDFRATQAYEEYKSPTATSIEQQPQKSPDVDGSSRSCGTATGLPITSLNSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIN9</accession>
    <name>A0A401GIN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional coregulator SSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0404490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transcriptional coregulator that functions together with transcription factor HSF1. Positively regulates the expression of laccase LAC1 during glucose starvation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with transcription factor HSF1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612983.1">
        <property type="nucleotide sequence ID" value="XM_027757182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIN9"/>
    <dbReference type="FunCoup" id="A0A401GIN9">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIN9"/>
    <dbReference type="GeneID" id="38778987"/>
    <dbReference type="InParanoid" id="A0A401GIN9"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="608"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE82070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="644" mass="70245" checksum="213808F25953BC71" modified="2019-05-08" version="1">MSKAIGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVSFSDNERLIGDAAKNQVAMNPHNTVFDAKRLIGRKFHDAEVQSDIKHFPFTVFDKGGKPYIRVQYRGEDKEFSPEEISSMVLLKMKETAESYLGGTLNNAVITVPAYFNDSQRQATKDAGTISGMNVLRIINEPTAAAIAYGLDKKTTGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFKRKHKKDLSSNPRALRRLRTACERAKRTLSSATQTSIEIDSLFEGVDFYTSLTRARFEELCNDLFRSTLEPVEKVLRDSKIDKGNVHEIVLVGGSTRIPRIVKLVSDFFNGKEPNKSINPDEAVAYGAAVQAAILSGDTSEKTQDLLLLDVAPLSLGIETAGGVMTALIKRNTTVPTKKSEIFSTYSDNQPGVLIQVYEGERARTKDNNLLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVSASDKTTGKSNRITITNDKGRLSKEEIERMVDEAEKYKAEDEAAAARITAKNGLESYAYNLRNSLNDEKLASKFEPADKTKLESAVNDAISWLDASQEASKEEYEEHQKELEAIANPVMQKLYSGGAGGAPGSFPGGAPGGFPGAAGGEEGPSVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ25</accession>
    <name>A0A401GJ25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0404910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613024.1">
        <property type="nucleotide sequence ID" value="XM_027757223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ25"/>
    <dbReference type="STRING" id="139825.A0A401GJ25"/>
    <dbReference type="GeneID" id="38779028"/>
    <dbReference type="InParanoid" id="A0A401GJ25"/>
    <dbReference type="OrthoDB" id="3366659at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41390:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 213 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="26571" checksum="501684ABCC107BBD" modified="2019-05-08" version="1">MDPSTPLTVARGTLITSAMTGSLAGIYGVFTRHTHVGPLVVSAAINGGIAGATFFSFREYVVSNLLLSALPTTSYYRRIREAHTRLQTQGNSGEKLTFWDMRAYKVPETAISSAFTGGLLNAWKRGPSGIAPGITTAAIVCTALQLAYNELGIARIKYVSKTLQASQKPHLSETSPSQELSSSKPHKPVAERVLSMLGFHRMSDTEYLDSLKQKRDRYLRRIAELEEERDSEKGQDPPNPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ76</accession>
    <name>A0A401GJ76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome assembly chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0405450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613078.1">
        <property type="nucleotide sequence ID" value="XM_027757277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ76"/>
    <dbReference type="STRING" id="139825.A0A401GJ76"/>
    <dbReference type="GeneID" id="38779082"/>
    <dbReference type="InParanoid" id="A0A401GJ76"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17132" checksum="08E26A7DE6E96B56" modified="2019-05-08" version="1">MPPSGQAFRVLDGIPTEVLLQTYADRTLVLVTQLGKVGNLIQATIPPTAPLLPAPPPNPLQPNVTPLPVPPTSIQLTPLLGNAPSDRLHTLYSLYASQIATVLWAEEAGNLLQGDRRGVVVGIALHKTAETEDDGLTEHEREVFHGVMDMVRDLLRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJB6</accession>
    <name>A0A401GJB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0406390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613168.1">
        <property type="nucleotide sequence ID" value="XM_027757367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJB6"/>
    <dbReference type="FunCoup" id="A0A401GJB6">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJB6"/>
    <dbReference type="GeneID" id="38779172"/>
    <dbReference type="InParanoid" id="A0A401GJB6"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000373">
        <property type="entry name" value="Vacuolar basic amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="562"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="591" mass="63734" checksum="7BD969FB7FFDDD00" modified="2019-05-08" version="1">MDEKRPQTAESVTPTQVAEPEKSKHDWKKNEEQHLPENRLGIVFAGLMCCVFLSALDQTIVSTALPTIVAKIGGGKDYSWVGSAYLLAAASLSTIYGKVSDVFGRKPVLYGSIVTFLVGSALCGAAQNMTWLVVCRAVQGIGGGGIMQLVQITISDIVSLRDRGKYAGLIGATWGIASVIGPLLGGVFTDHVSWRWCFFINLPTGGVAFMLLFFFLNLNPHQGKPLRQHVREFDFVGLILIIGGVVLLLIGFNFGEQGWDQARTIAPLVLGVCLLIAAGVNEIFTNRSPIVPPRLFKTRTTTFLLVSTFIHAVAFFCGTFYLPVYFQVLGSSATMAGVRMLPYSLGSSFFSILSGQVVTRTGRWRPVLWVAWGIFTLGYGLMIMLKADANVAMQVLYPLIAASGFGNLFQTPLIGLQAAMPIKDMATSTATFGFFRMLGGTIGVTVGDTILSGILQKKVKNIAGLSIDTSAAALNQYVPFIKHLPDSQRVPLIAAYCQAISTIWVVNTPLVGFGFILVLFVRGYSLKRVIVKAGPQGQEDAIPADVEKGEIEQVAVDAITAPDGEALDEDGQARSSMSQDDTRMNGQLRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJI3</accession>
    <name>A0A401GJI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNase P/MRP, p29 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0407100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613239.1">
        <property type="nucleotide sequence ID" value="XM_027757438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJI3"/>
    <dbReference type="FunCoup" id="A0A401GJI3">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJI3"/>
    <dbReference type="GeneID" id="38779243"/>
    <dbReference type="InParanoid" id="A0A401GJI3"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="284" mass="31413" checksum="137C7C0EC101B146" modified="2019-05-08" version="1">MDIYTGPPPLINYSVKLASSAPFTPTYVKGNISRSADAAQLYASRVQGRQILLENPVRESKEKKAREERKAKRLAEKARRDSGIIGRRDAPRHGLWRLKREETKFSLFLPLHSLWLGYMSELLALPPAPSIPIARAVAEAVPNAAAMHAKLVKADFHGSLVTVRQSKNPCLVGLSGIVVHETENTFKVVTKNDQLKLIPKQNTIFAFAVPLYSISGSDLPSSSTSDHGSAITSASGDPAAPRSERAQTVLDMPHVEFELYGNQFCFRATERANRKFKHKETIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK49</accession>
    <name>A0A401GK49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="4 16">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0409310</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="15">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="4 16"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613460.1">
        <property type="nucleotide sequence ID" value="XM_027757659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK49"/>
    <dbReference type="FunCoup" id="A0A401GK49">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK49"/>
    <dbReference type="GeneID" id="38779464"/>
    <dbReference type="InParanoid" id="A0A401GK49"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 16" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="18">
        <location>
            <begin position="6"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="19">
        <location>
            <begin position="213"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="12">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="346"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="351"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE82547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="389" mass="43512" checksum="E159323CC6A4D3D8" modified="2019-05-08" version="1">MAELQFDPSTHPHRRLNPLTNEHVLVSPHRTKRPWLGQTEPPQSSRLPEFDPKCYLCPGNARAGGQRNEVYEHTMVFENDYAAVLPPPGPVAPPAPHPLLTTEPVQGGCDVLIFHPRHDLTLARLPLKDIERIIEEWCAIYQKRGTQDGIKYVQIFENKGAMMGCSNPHPHGQVWSLSAVPSLPATELANLKRYSLSDVQPSGAPKGLQNRPCLLCEYAHFEVGADYEAGRVVVKNEHWVALVPWWAIWPFEIMLLPYTRHITSIADLSRAERVSFADLLSKITKRYDNLFSCSFAYSMGIHQRPIPSATVNVGDTLLAGDQDLGDVAHLHLHFTPPLLRSASVRKFLVGFELMAEPQRDLTPEQAAQRLRACSEVHYLDAAEPVAGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK67</accession>
    <name>A0A401GK67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0538 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0409370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0538 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613466.1">
        <property type="nucleotide sequence ID" value="XM_027757665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK67"/>
    <dbReference type="FunCoup" id="A0A401GK67">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="GeneID" id="38779470"/>
    <dbReference type="InParanoid" id="A0A401GK67"/>
    <dbReference type="OrthoDB" id="937at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018794">
        <property type="entry name" value="UPF0538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444">
        <property type="entry name" value="UPF0538 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18444:SF9">
        <property type="entry name" value="UPF0538 PROTEIN C2ORF76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10209">
        <property type="entry name" value="DUF2340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="16102" checksum="BFB4DE4FC70D9386" modified="2019-05-08" version="1">MSDEISDVLTNLALPSTSATLTLRIIKSFEYRTERSLVLHNINLDTTTVGQLKEIARQAVQREPGWKAYRTLVLDTIKVYAKAHGAKTTNLIINLDHDEWILTDESKTLTECGFENETEASLFNREAYETFKAHPETKWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKJ8</accession>
    <name>A0A401GKJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613577.1">
        <property type="nucleotide sequence ID" value="XM_027757776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKJ8"/>
    <dbReference type="STRING" id="139825.A0A401GKJ8"/>
    <dbReference type="GeneID" id="38779581"/>
    <dbReference type="InParanoid" id="A0A401GKJ8"/>
    <dbReference type="OrthoDB" id="3271031at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="291" mass="32861" checksum="53CFDC471BB33BE0" modified="2019-05-08" version="1">MSTLRLEFDIGLNLHNPADDDSLLPIVLHRLTSSGESPDGPSLSETFYVRQGNRIHRGRAAHVWAGKMQKGDGRLIDIVLKITIGRDRHVDLIKEANFYQNELAAVQGNIVPRFYGIFQGHIRTLLMTCMVLEHCGEHMTKAQHEDMDFKVELISRLGYLHSICGVEHGDVCSSNILVKDGFPVIIDFECAQPHRCERKMTIEVGKPWPPVLDFGCFELYDVARDFELWGPAIVEFLDDCISVRQITSAKQLVDLTLHNDYTDRAKALEDAQELVQYLVGMGTLPESVLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKW9</accession>
    <name>A0A401GKW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein SnodProt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0411740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613702.1">
        <property type="nucleotide sequence ID" value="XM_027757901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKW9"/>
    <dbReference type="GeneID" id="38779706"/>
    <dbReference type="InParanoid" id="A0A401GKW9"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019355847" evidence="4">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="144" mass="14827" checksum="CA3A72B4639B1D54" modified="2019-05-08" version="1">MKFAAVIASLSLLFAPTILAQTSVSVSYDTTYDNSAEPLSNLACSDGANGLEHYGYTTLGSLPDFPYVGGSHVVTGWDSTGCGTCWELTYDGTTITVLAVDTAPEGFNLSEEAMNALTNGQAVAIGRLTATAVQVNSSQCGLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL13</accession>
    <name>A0A401GL13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0412210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613747.1">
        <property type="nucleotide sequence ID" value="XM_027757946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL13"/>
    <dbReference type="GeneID" id="38779751"/>
    <dbReference type="InParanoid" id="A0A401GL13"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="362" mass="37939" checksum="6D9A1966CAB33F06" modified="2019-05-08" version="1">MPPCRGACTPTAPVMQDTDDVPATSPAPGARDHDSAAPTRASTVPQCSCTTAPAAAAAQDANDAHATSPARGVQARDSPTPTRLAVRATDRPTAQVVPSAPTHHGCTTEPAVATVQDADVATDTPLAPRMHHAGADARARPASLTHHTVLTASGAHTQDNALTTLPTPRARQASATTRERTTSPTHPITTLPMHHAASPVRGARVHDNTIPVRPEAHHAVPAVNHPMVPMDPSAPLVHPPSPPTTHPASDVHDGPPPPSCTIKQPTSTAPADHDAAPRHRTQDTPEAAAPVYDGAQLLPHPPLSTLSTPLLSVPPLQTRGPNPRLCHINWRWQWARPQDPCLPNHCMRSPQTPPVIVYGTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL97</accession>
    <name>A0A401GL97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0413340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613860.1">
        <property type="nucleotide sequence ID" value="XM_027758059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL97"/>
    <dbReference type="GeneID" id="38779864"/>
    <dbReference type="InParanoid" id="A0A401GL97"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="522" mass="57166" checksum="E6C5D62BCFE26F44" modified="2019-05-08" version="1">MLTQRRPSSSDTRTTHSDEHPPSNARPHPVRPAHQPITLRLPAVKLAPRASLTHIAPRLSRTSVPRTAPTYRAELDQLGRSTHALLQESRATPLASHPGGILAKEVKARTREALPGRAPGQRTQRPSAHAHPCACTPLPDPAPSYCWPLFMVRTTLDIAAFRSASFVRAEGAERVPRFDSSGTARSFTPRPPRSLANGEFVRPTPYFDRCERRRVRSCSRRRSAPSSSSSSAASVVPSHVVYSPPPPLLPSQSATGPVRPASYGPPHPARHRHRDRCERTLSEPPVLRVLVAPSSFDPALYCVAGWPGRVITVPVLPAGSVFSHALSLRFGLWLCVAREVGFGRAVLRRVSRGQRVLFSGQRVLWSSRVMVPDESMSTISQARLPRARARPTAEEQETAKTEIRSDKTRHNLNLPAASASASALEISLALCPCTTSTPQKSVFGSRLAALQRRDTTARRGRRRATGDGRRGGASTRPTRAQESAVRHRQVRPPLVFAFSGNVLPDLCAAVRIRSRRVMYSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNF9</accession>
    <name>A0A401GNF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0507880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614645.1">
        <property type="nucleotide sequence ID" value="XM_027758844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNF9"/>
    <dbReference type="STRING" id="139825.A0A401GNF9"/>
    <dbReference type="GeneID" id="38780649"/>
    <dbReference type="InParanoid" id="A0A401GNF9"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="712"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="871" mass="98549" checksum="3EB86293350CF641" modified="2019-05-08" version="1">MSHPVAGTSSLQSDPPRRRRQRACDICRHKKIRCDGSQVLGRRCSPCKAQNLPCTYTDDVKKLWPDNQSVVELQQKLERMESLLAQLSPGTVVQQELDQTVENNQQTNPNTSFSTSRFSTPSDQRTNTNFPTSTFSTPPELDETEFPDEYEDADGAVGTIGEKITSILDPMQNLSFSTPRFYGQSSGVLSVHKVINSRNDSAQSSPSPEGDPFNLRLNYKREKFWSVDPWELPVGEENECNYTFPDHDLLISLVDLYFEHVNVFTPVLHRPTFERSFAEGLHLKDRQFGAVVLLVCAVASRFSPDPRVLYNGTNSRYSAGYKWFQEVQIVDRHSLSAALTLYELQMYCLAVFFSHWTTTPLACWTIVGIGIRRAQDVGVHRRKVHRGKVDTVENELWKRGFWVLVVMDRYMSSALGRPCAMQDDEFDLDYPVECDDEFWLQDDPAQCFKQPPGRLSVITFFVLYVKLQQIIAMALRTVYSINIQVKVLRRLVGPDWQEKIVAELDSSLNEWTDLIPEQLRWDPSREINLFFNQSAMLYASYYHAQILIHRPFISPAKRNSSLALPSIVICTNAARSGSQVVGLHRQRSSELLPYIHMPIFTNGIVLLLYIWGNKRFGFPVGDVSRDWAAVRLCMDALRAEETRWQVAGRLWDILHELTRIIEQTEPASPDLSRPSEVTASHVRNSVSSFTAPLSAANNDVVGEGVREGQVLQEQKRVPFQDYQQRRPSDRLSTMPASFSPSQPHRQSPLQPMSGGGEGTKLHNQMDRNFASGASDMALTENQPFYNHMPSGQSYAPQACSTAQDIQTTIDMDWSAMQGVEGLDPAFTDDTIEMWGSAPSSFELADWDMYLSNGMVVTDNPPLGPTWGAIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNR0</accession>
    <name>A0A401GNR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial intermembrane space cysteine motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614794.1">
        <property type="nucleotide sequence ID" value="XM_027758993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNR0"/>
    <dbReference type="FunCoup" id="A0A401GNR0">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNR0"/>
    <dbReference type="GeneID" id="38780798"/>
    <dbReference type="InParanoid" id="A0A401GNR0"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="153" mass="15711" checksum="9C92FA045DCC19B2" modified="2019-05-08" version="1">MPRQSRSRPAARPAAPRPAAPAQTRSASTAAAPYAGSAAPHAHHAPPVPPQAQTQSREPGMLAQMAATAGSVAVGSTVGHGISHMLFGGSSSAPAPVEAQAPPVQQQQSYQSQGISCDVQAKEFTKCLEKADLPSCTWYLEQLKACQAAAAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNZ4</accession>
    <name>A0A401GNZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0509260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614782.1">
        <property type="nucleotide sequence ID" value="XM_027758981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNZ4"/>
    <dbReference type="STRING" id="139825.A0A401GNZ4"/>
    <dbReference type="GeneID" id="38780786"/>
    <dbReference type="InParanoid" id="A0A401GNZ4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11705" checksum="1534E1FEFD6E498F" modified="2019-05-08" version="1">MQVNTDVWGPNAAEFVPERWIDSGGMLPPAELPHGWSGLVTFCDGPRNCIGYRLAVFEFKVILATLIRTLELHDTTANVELKIKPTLQAFVDGRGGFLPIHFTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP33</accession>
    <name>A0A401GP33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0510600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE84001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614914.1">
        <property type="nucleotide sequence ID" value="XM_027759113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP33"/>
    <dbReference type="STRING" id="139825.A0A401GP33"/>
    <dbReference type="GeneID" id="38780918"/>
    <dbReference type="InParanoid" id="A0A401GP33"/>
    <dbReference type="OrthoDB" id="3270142at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22565" checksum="86793F39BF13D0AB" modified="2019-05-08" version="1">MTDCLGSDVHLTSMHTDITAEDFAALFFEKWYCENGLPLDIVSDCDHLFISQFWKALHKLSGIKLRMSTSYHPETDGSKNDGQFNNGKFFNAIIELLSDKEDKNTQETLTWWNEQVFGKKEATSTVTEPAATSVTQIKAQCAAWHAANAANPVSGRSMSTTAVSMLNRPASHPPELLQHRNSLSQSPTPSTRTALSQPWVKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPF5</accession>
    <name>A0A401GPF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metacaspase-1A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0600990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615034.1">
        <property type="nucleotide sequence ID" value="XM_027759233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPF5"/>
    <dbReference type="GeneID" id="38781038"/>
    <dbReference type="InParanoid" id="A0A401GPF5"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="160"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="414" mass="45910" checksum="F0603A4791A6CA0A" modified="2019-05-08" version="1">MMWDFSGANGAQGSPPDSYLQVPGQSYQPTFPVPQTRYGSSPVVPFAPIGASSQSSHHQSPYPHSPHYSSYQSLAYTPDSQQYGSGQIAPRAVVNTHTRTHQHHSSHHGHVHHSKHSSQQRDPPSHSRPAVVGHHAPEMAVQPIQSRQHSRFEYSKCTGRRKALCIGINYHGQSNELHGCINDAKNVQQYLIDHWNYKAEDIVLLTDDSHNPRQKPTRANILNAMHWLVQSAHKHDSLFLHYSGHGGQVKDIDGDEIDGLDEVIFPADYRTTGHLTDDLLHTVLVKPLPAGCRLTAIFDSCHSGSVLDLPYEYHSDGKAKGSQVTPSHIKEKSTPADVISWAGCMDSQTSADIYEGGVAVGAMSQAFTKALSSKQDQSYQELLRNIRAILNKKYSQKPQLSSSHRIDTNMKFIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPN2</accession>
    <name>A0A401GPN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615033.1">
        <property type="nucleotide sequence ID" value="XM_027759232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPN2"/>
    <dbReference type="STRING" id="139825.A0A401GPN2"/>
    <dbReference type="GeneID" id="38781037"/>
    <dbReference type="InParanoid" id="A0A401GPN2"/>
    <dbReference type="OrthoDB" id="3253399at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="320" mass="35276" checksum="04129205573732AA" modified="2019-05-08" version="1">MAPHTTTSDSSDDDETPETFSFGLSKKAAKGAQDALQQFAATEKQKRKEKNRERDRVLKERAARAKVKSGGKGKGKVVVKEKAPRVDQEVSDEDGDEAGRDDLRARMDRAMREAEEEGSDALTENGEDMSGEEGSAISDDEEEDSEKDDEDEEMERTRVYADGDSKDEGENEAEDGDDEMGAEESDDDAPSPRKNSAHHDYLPDHLFKSAFAAAAHSRSQPKVPTSSATKSQKRKRVKRSSKEIVLGSRTIRTLPSTSGAILSTAHRRLVPPARVNEFVKRSLNLKGRAADMKIKGWARRAANVGVMKRDGPAARFVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQB8</accession>
    <name>A0A401GQB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo25-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0604100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615344.1">
        <property type="nucleotide sequence ID" value="XM_027759543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQB8"/>
    <dbReference type="FunCoup" id="A0A401GQB8">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQB8"/>
    <dbReference type="GeneID" id="38781348"/>
    <dbReference type="InParanoid" id="A0A401GQB8"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="329" mass="38356" checksum="3E29238F1F40DB97" modified="2019-05-08" version="1">MNFFKTKQRTPPDLVRGLRDSLSKLEAGPPSTETRRKANEDVVKNLQQIKAILYGDGDPLPELVAQLAQETYSTDLLHSLLLNIDKLEFEMRKDVVQIFNNLLRRQIGARFPTVEYLCGRPEVLFAAFNGYSKEEVALNTGMILREMLRHESLAKILLYSDQFYTFPHYIEATTFGVSCDAYTNLKETLTRHKTMVAEYLDKNYDRFFASFTTLINSENYVTKRQSLKLLGEILLDRANFSVMTRYIASETNLKLMMNLLRNKSRNIQFEAFHVFKVFVANPKKPPQIESILRRNKEKLLQFLKGFHNDKEDEQFTDEKQFLIVQIQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQG0</accession>
    <name>A0A401GQG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0603680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615302.1">
        <property type="nucleotide sequence ID" value="XM_027759501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQG0"/>
    <dbReference type="GeneID" id="38781306"/>
    <dbReference type="InParanoid" id="A0A401GQG0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="403" mass="44372" checksum="A525B209E5D9FB08" modified="2019-05-08" version="1">MLTEGYIEERLHGHTNLKIPRIVKWHEDDMELSVLDPCHALIPLVINAEGTRLRLVRDAKDSLKVPGCLATKPELDSNSESEEEEEDQEALPPPPPPPPLRSKRSKSKSAGTKAPSATKVGGTNQVRKHRRELDINEDVQSDEVQEVIPVIRDIRGATTRLPLQHAASPHGHVAPRSRRQYEDELEGYSSADSVHAGIDNRAATRYQGQLPKRHAAPLPKPPSVIPPSWLPSGNAPSTGYSHGYSPTIAYVPRASNSVGGHARGYSPAAGFPPHLASHAHRSQLQCAGHPQPLAVPSHQDLSIQEDENHRYHYQAHTRGAGRQDFVRRADNVIEEEDEFVDKGRMPQQLMHAGRAMPGRTFTNAVAGPSGKYSHRHAEAGPSYIDYAPDDVGALFDDPVYYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQR1</accession>
    <name>A0A401GQR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pogo transposable element with KRAB domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0604790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615413.1">
        <property type="nucleotide sequence ID" value="XM_027759612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQR1"/>
    <dbReference type="STRING" id="139825.A0A401GQR1"/>
    <dbReference type="GeneID" id="38781417"/>
    <dbReference type="InParanoid" id="A0A401GQR1"/>
    <dbReference type="OrthoDB" id="2800589at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="85"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="519" mass="58201" checksum="E6E114D339EC3155" modified="2019-05-08" version="1">MVGRPKSESKKRQIQVKIKASLQRQAVAAYQEELAKRALGLPARGARAICDYVTAEHKQKTGTEIKFNHATIINHARGLHRPRTEHDAENGWLTLTEVELVLQYIIELGNRGFPLSHRRLKEHVDEILQAHLGDTFLAKGVGKNWTHRFIQRHSDQIKASWASPLEEKRGRAVNPHTNEAWFKLLEDTIRDYDIVPKMTYGTDEIGCSGSTGPSEHVLGANKKGPQYQQIGGDRENITVIVTICADGSATPSAVIFKGKGYQVSWKQDNPANASIGYSKKGWTNGEIGVEWIKDFDERTKTKAAGCYWLLLVDGHNSHYTRSFLQYARMHQILILCYPSHGTHVYQGLDIVVFATLKRYIREERDKWERSTGQKLKKENFLTIYRRAHMRAITPETVKAAFRKTEVWPFNPLVVTEEMMALSKETSCEGQLPLVLAMSVRVIAKMLHDLCIKDDLPDSDEEIEGVLDMESGSDSDEGDVGEGQPCVAISYPPSSHTDPAEVSTLTSTVANSADVIKEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR79</accession>
    <name>A0A401GR79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0607180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615651.1">
        <property type="nucleotide sequence ID" value="XM_027759850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR79"/>
    <dbReference type="STRING" id="139825.A0A401GR79"/>
    <dbReference type="GeneID" id="38781655"/>
    <dbReference type="InParanoid" id="A0A401GR79"/>
    <dbReference type="OrthoDB" id="2750871at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="2"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="517" mass="58869" checksum="D7361C7CB0680372" modified="2019-05-08" version="1">MGLYPGTVKDPHTAFTFAVLDDFLLENKECKTAALNYYSKLKWVTSNAFPGTIPDRYRELMRVSRQWCQLKYRKWHGFSHDALRPVEKGGLAIFCPACPQPGLNLPFDWQADPVQWKFKHGFVMDGNFSAEHMKMKHPEEDVALSNGQAFMVGQEDYKAHLAVAMESHQVRVWLHVLLPPLTPKPTSRSTCHEHRAVNQANVDRANLDATGIGATACTRHGFFVPHTVVDFQKGERQMNMDYSLSNALLTLTGITLVLVMYDIMCQYGIHVRKRFRHSAYLRMPFELKIDQGIGLFHVHGHQDCCFQWFSPNFIVGAGMVDGEVIETLGMTRAHRQEVLDDHMNDSNWKKTTRMVLTLMTKWKRVLLGFPRSKESFEALSASTDEEVLEAWQKEYDDAMEARQNDPKIMDTFDVQLRKAPGKDLTQLRLAGEESAKGLEKGTAGWLSTGLKIQEAQLKLANDIRKAGQNPSVAEDLKTLERHQHLEVSILTFQRRSEKFMGRLEDVPAMEDCDDGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR84</accession>
    <name>A0A401GR84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0606580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615592.1">
        <property type="nucleotide sequence ID" value="XM_027759791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR84"/>
    <dbReference type="GeneID" id="38781596"/>
    <dbReference type="InParanoid" id="A0A401GR84"/>
    <dbReference type="OrthoDB" id="2811554at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="293" mass="32784" checksum="FDF93D6A135CCD9F" modified="2019-05-08" version="1">MSSLKTLHPGFRPGMTYAAACQVPPLTELPPALEPTDFGLLPPIMHYGYIIDRSQFSTIGTAKFGITRETSGGGWEEVALHMVANDIAGAVIDYPIKVVRVCTGLKRPLILSLSSNWYPCEQLEELDARLNTNHHCHPIMSSLKDIHPGFTPGAPFALVRQVPAYEDLPPVLKPTAFGPIPPIMHYGYVISFEQFFAIAATQLGFSKEVDGPAWSEDIAMHQVADHIASEVIHHPAKVAWVCVDRKRPFLLSLCTNWYPSQRLEEVDPKVREFLGIEEKGKWYLDVTQRKWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRQ6</accession>
    <name>A0A401GRQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0700290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615762.1">
        <property type="nucleotide sequence ID" value="XM_027759961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRQ6"/>
    <dbReference type="STRING" id="139825.A0A401GRQ6"/>
    <dbReference type="GeneID" id="38781766"/>
    <dbReference type="InParanoid" id="A0A401GRQ6"/>
    <dbReference type="OrthoDB" id="2800603at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="46508" checksum="C13C242960449283" modified="2019-05-08" version="1">MQERLMFNFDVATQADASKHVLGNRVFEPLFRVRNFDVSINCILDFDDDFLGAMSRAWPALGTFECNIYRRWGPGKPRATVAGLIPLAQNCPDLFSLELALGIGLKRKEIDLEKLPGGGMHHSPLENMQVGFSVVSDTEALAAFLSGLFPQLWLIGTGWPVEEDEDAEYPEEEWEKGRVLAELHVTVERASDDAPDQARKFFAALAEHRSRRMLQILEFNFNVGVQVDGTKHVLGNNIFKPLLTLPRVDKLEMSMNCVMDFDDNFIAAMSRAWPALRKFESNVDHRWGEGKPRMTLAGLVPLSQNCPDLFSIGLTLDANLTGKDIDLEKVPKCGEHQSFLEEMHVGYSIVNDPELLIRFLSGLFPHLRFISTAWPNAHEDEEAEHPDEEWEEGRKWAQVKVYFPHDDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRS2</accession>
    <name>A0A401GRS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0700830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615816.1">
        <property type="nucleotide sequence ID" value="XM_027760015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRS2"/>
    <dbReference type="GeneID" id="38781820"/>
    <dbReference type="InParanoid" id="A0A401GRS2"/>
    <dbReference type="OrthoDB" id="2940229at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="39454" checksum="4C35FE7BE9FACF25" modified="2019-05-08" version="1">MPFTDVVNTRDTTTNSAHAAPTCATKRAFTGHEDIDAACGVTKKPRIEDAASSDATGESAASTSPPNPYTILSAPCPTYIQLRFQLARFRGVYRVHAHRSEICTNVVMYSPSNGRKGEIKKYGVAPPPEPDRDEDLEEWFAWMQKWHHPNNNPVMEVVPCGMRNRRPLTYGFEEPISYEIKQNHEVTVGDVWSLERDHNASGGECANDEIAVKLLYDLGSSWEVHISVEPNHEGSFGFTYDPPKNVPIIVTAKGAPPIEDTHGDVPGELDAKKKKVSKLLFAPNSFAKYLAGEIGTSSRKMELAVYNVAEEAKRQRAAAKEREERRKQLEKEREERCTRGEESDEDDEEDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS89</accession>
    <name>A0A401GS89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IgA peptidase M64</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0702620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615989.1">
        <property type="nucleotide sequence ID" value="XM_027760188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS89"/>
    <dbReference type="GeneID" id="38781993"/>
    <dbReference type="InParanoid" id="A0A401GS89"/>
    <dbReference type="OrthoDB" id="2961863at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55242" checksum="E83A6B94CDBC39D4" modified="2019-05-08" version="1">MSSGRFGEKVSPPPLQVEPLFSSGHPSNRVDLVFFSDGYTVEEKDQFIADATRLAMDISNNHTFNTVKPLLNFWAAFSPSNESGIGTGGVPKDTTFGLYRDGTELRGVYYSKPDVARAACFSMGDRCDYPILMGNDPLYGGLGGEFTVITPSLANGALVLRHELGHSIIDVGEEYDGGYAYFGVNAAHDISKAIPWSHWLTNASSISVHHHDHDNDHTSARVERSIMPMQAYPWTMLNVSSPWCISFSSSGTYARHLVRFSLSGLPQMGDLLVELDGQDLLWAPQPDIGVDRWHYDVHPNGALSEGVHELKFTLRNKDVEGTAQLCSAEILEFGDETEFVATPGYYGAFPTFSERNETTYRPTNEDCLMRVVTTPNFCKVCIEGLWLSLLKRVDLIDSLNAGCKLEEGRWKRTLGLDLVPLAQFREEAVEVEESYTITWAKNGDILATFANQTRIEVDDADALGTYTVDVQFTTPEVRVDKDGLLTSRVVYAVTSSCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSI4</accession>
    <name>A0A401GSI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF862-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0703160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616043.1">
        <property type="nucleotide sequence ID" value="XM_027760242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSI4"/>
    <dbReference type="STRING" id="139825.A0A401GSI4"/>
    <dbReference type="GeneID" id="38782047"/>
    <dbReference type="InParanoid" id="A0A401GSI4"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="196"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="342"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE85130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="71688" checksum="D4D2C204ED4E483B" modified="2019-05-08" version="1">MPNKVELYVYDLSNGLARQMSLQLTGRQIDGIWHTSLVIFGKEHFYGQGICVTAPGQSHHGRPLQIIDIGETEIDEATWQEYLNEMRSLYTADKYHLLDFNCNSFTNDCVGFLTGNSVPEWIKDLPSDFLSTPFGAALRPTIDAMFRRPTPGVVATPPTLQSSPVATSAPISASPDPALTASLLQAVASQALSQTMSSAIPAPAQATSTLTAPVHMCSNPSSMHSLLRSHRAVVAFFTSKTCPPCRMIEPVWDEVAREKTHGNGNASGTAFAKVDMGVGLGGQVGAEWGVRVTPTFLFFLDGKKFHELKGANAPELRTQVNLLLFEAFPPHKHTSLSLPSVEALSTSPILFTQVPTLDSVFAKLSSFLDASSPSHTQAAKDTLSTSLLPYLKARFPTASGSAKKPAIPPATPQQVSRWAEATRVIASALSPAQLFPLVDMWRLAVLDETVGSWCATAAPTVNPVHIFLGHAIRALDEAQANARNYVLVFLRMLANAFVSTTLARTVLSTGNLGNRAPTTKVLVSSLLHGDAAVRTAAASVAFNVAAFLQKGRVNSLRGANIAATGNAEEDGEWEVELVSAVLEALSNEVQREEVVHRLTAAVAFLLRLSPVYDTQLVPFLEVLQARDTLKSKLVKGGCGPEGVQKKDVRKCRPDYAFVLFEREGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSZ2</accession>
    <name>A0A401GSZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0705390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616265.1">
        <property type="nucleotide sequence ID" value="XM_027760464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSZ2"/>
    <dbReference type="STRING" id="139825.A0A401GSZ2"/>
    <dbReference type="GeneID" id="38782269"/>
    <dbReference type="InParanoid" id="A0A401GSZ2"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="18"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="538"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE85352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="68696" checksum="88D41F67B314D5FB" modified="2019-05-08" version="1">MKIHLRLGLTDSWHSFYVLIVGGGPTGLVTAHILVQAGLKVLVVEQYNAPGQALYGRAAILYAGSLEFLDTIGIYNRIASIGYIVTDSLTFKDGKEIHGRGWKPFVKAMAGNTYFEHCLSIRQKYVEEAVRTAISAVDPTAVQAPAKLVDFTIDNSFDHSVIATVEAGENCIEVRSKYILGADGGRSTVRELSKIQFPGTPGKFKWVRLDAIVQSDLPRMTTAIESTSYGHVLWMPIDNGATRIGFVCSDALYGEKGENITAELVMEEAKKAVAPFKLEFVTLAWWTVFQFGQRVAERYQDGPVILAGDAAHTHSSGAAQGMNTGLCDAANLGWKLAGVLRGWFKDEILDTYTSERKASAEHLIQLDRDVSTLISGTIPDHFCAPPGADPNIYLQQVFSASADFTVGLGVSYSENLVNVARETDAVLAAGLRVGHRVRDVPLFRPGAAFPTRLLELTPYIGKLWVFILAGEVEKTPEGVRLNEKCATKYHALRQSFDSPGSFTRTLAPAFDFITILRGTGVLQPAETLGTQLIGTVAYDQTGDAYDKYGVSTTEGALVVLRPDAIIGFIAPLNGALELGQYLSELLRPVEAGVAMEEQLVTTLGEIALDDRNEGELIRIPMMRVQSVDNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT57</accession>
    <name>A0A401GT57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWI/SNF and RSC complexes subunit Ssr4 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0706080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616334.1">
        <property type="nucleotide sequence ID" value="XM_027760533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT57"/>
    <dbReference type="FunCoup" id="A0A401GT57">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="38782338"/>
    <dbReference type="InParanoid" id="A0A401GT57"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="39778" checksum="4E87B2ED6857999E" modified="2019-05-08" version="1">MSLHQDGPCLRYPENLGLHPTITHEVAVSMLLRATQLAQTTPFTWGYIDKPSEGQLFLVFITQQQPILQDGLRYQEQEQRYVLPAGPGRELEVMETKFGFIPGQDSVAFRMRRRYRLHKGGHPQLMLIHYLRGQNVPIVPSLNQPARVYPLRPLNEPSIFVMGEKMGQKVFTGSGGSAPPGERQQSLPPPMAAMNMNFGVGMSGNAQALLAAQNSNMEALERRSQRDRSGSMSTRQTQLPPSRTEDEDSADESDLISTRALALTRYKRNHELMNEVFMYAAFSKLKDNAPRAPPYSIFNKDELEEKAAKLAAEIDVLKAKAASRQEARLRAEASSGPDDAGDVSMTIDPPNAAEGIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTD1</accession>
    <name>A0A401GTD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0706530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616379.1">
        <property type="nucleotide sequence ID" value="XM_027760578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTD1"/>
    <dbReference type="GeneID" id="38782383"/>
    <dbReference type="InParanoid" id="A0A401GTD1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="128" mass="14859" checksum="930384577BC61CE2" modified="2019-05-08" version="1">MQAIREALEQTRQAQNERFERIMDKLKNSSGDKVDPMDQPVPSGMRNSIEEIAVERGLYPSEVEDPTAGAPDIIIESAYHWLARPQQEGELDEDYNRRVLIYTRYLDKMASESERALRAFTFSLRHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTL1</accession>
    <name>A0A401GTL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0702600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615987.1">
        <property type="nucleotide sequence ID" value="XM_027760186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTL1"/>
    <dbReference type="FunCoup" id="A0A401GTL1">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTL1"/>
    <dbReference type="GeneID" id="38781991"/>
    <dbReference type="InParanoid" id="A0A401GTL1"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005681">
        <property type="entry name" value="Tim23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00983">
        <property type="entry name" value="3a0801s02tim23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="209" mass="21637" checksum="C72A49D51698AACF" modified="2019-05-08" version="1">MDSSGSSSQDPTSVLRGATFTRSEGSPVPSDAVTASDVLLGSFDPARLHPLAGLEDKLDYLQLEDDQVSNMPGSGTAIPSRGWSDDLCYGTGTLYLSGLAMGGVWGLREGARRPLAVSNARLRVNSILNSVTRRGTFIGNSAGVLALAYNGINSIVDTLRGRHDTVGSMAAGALTGALYKSTAGVRPALAAATMVSACAGIWSYVKNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU43</accession>
    <name>A0A401GU43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0802210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616612.1">
        <property type="nucleotide sequence ID" value="XM_027760811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU43"/>
    <dbReference type="GeneID" id="38782616"/>
    <dbReference type="InParanoid" id="A0A401GU43"/>
    <dbReference type="OrthoDB" id="7862095at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="218" mass="24131" checksum="F8CA3BC8A4812C14" modified="2019-05-08" version="1">MSRHFCCCIPVRAGVFIFSLISFLASTALAVLAWIATYKVHHDPGQHMNISNTAKIIIIVVGSISTLIALISLFGWIGSITRNRRFVKAYSALSWVIFLLSLVSAGFFLYIVYAGKALYDCISVDSNLHVDTNVSCDFHFSLGIKILVTVITVLQILIHLYIVVIIRRYVDQLEDGDESWRSPYTLGLVDPRQGLLNPASEAYPYSDATHAFGKAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUN2</accession>
    <name>A0A401GUN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0804610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616850.1">
        <property type="nucleotide sequence ID" value="XM_027761049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUN2"/>
    <dbReference type="STRING" id="139825.A0A401GUN2"/>
    <dbReference type="GeneID" id="38782854"/>
    <dbReference type="InParanoid" id="A0A401GUN2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="123360" checksum="3CD4D7C5CCB0FBA6" modified="2019-05-08" version="1">MTLDIDPNYVLQAARLTAIVAAAPRQDDPRYSDWEARIYLEVSRLEKSFPQPLKSLRMPGIVISALLEFTRAYQQKALARLDHISNDDERIYKRYPLAVREYGECEDLGRQWWTEDPYCKLPLVKSMPAEGWGNVPADDDTQGRGEEDLATGDLVTKGKGKERADNDVGTGMVGERIVHVEAGEDKGKGKSKEKAQGKAVHAMSEEEDGGEGEGEGEGEEQEGEDNDDADSDKDDDADKDDDDEMAEDVLGAGQPESIEVDVASPPPPTARPISISPGAPSLRKCKAVITESSEESENEEAAPKAKQMKPIEVAKEKGEAPTTSGRAQRAQKRMAQTEVEGSKVSTKKSGKRKVKESSDEEEVPTVKPPKKKHATKEYKSKEFIESEDETPAPPSNLPAKTAGDCNDGVAKTNAPAKPVKQTTRMTATPHVAPKAKAKGKAKATAKGKATAKGKAKVTVSQKDMWKKTSTRVSDFMWAHATDSLVPCVGCQEKEWPCKLNTANFGRCLECAARGVSCSITPRNTDGVPLRGNSHTAQREFQEMCAALVVEGKPLPTSPPPYDVKVDSDEPDGAEPMVMGASKCKLPKKTKTRNAAASSSMVKGGEEVEAMKQKATVTRYEANAEGEASVEKSSKSKRATKSATATGAVALSNSGEVSKSGAPAKSGAVAKPGEGKKSGPKPKPVRSQNSGAQDGGEVTRTSVREADEVLPAKSVAKEGGQTTRVAMGGRSGPMVPVITRKAKASAPKAAAKMPLAEGDGMEEAARLAMEAVRAMAFQTGPAAPPQASSSKRMLTPVADESEDVPEFQAEVAEDERTSLERPHDDRRHSLLMHHETSAGAAKVAQEVMPSLEISKASKGAKSSTLAKAGHLDEGRRPAKRGAPLDRNAAKKEAEAKRDAKANRLRAVPPTSKAPHLRDVQRVSTGSPAPVNEGDTPSGEETSQSSNDDCANCAELRQEFLAHKDGMEVQFQERMADLNTVKAEITAALQRINPPSAFQENARSIREEVKLAMEEFRRPVTIELQESVKLEQGANQTVSQADVDKLQGKLADLRHSMELQAARSDSMEKELRSSAAEAIAQASKLEMELALAKEDSMAVATSALDEAKKVGKEVATVREETSLVAKSLDAFREKVDSAMVFTAFRPDSHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUN6</accession>
    <name>A0A401GUN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0706310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616357.1">
        <property type="nucleotide sequence ID" value="XM_027760556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUN6"/>
    <dbReference type="STRING" id="139825.A0A401GUN6"/>
    <dbReference type="GeneID" id="38782361"/>
    <dbReference type="InParanoid" id="A0A401GUN6"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1227" mass="139612" checksum="24F5EF545011148C" modified="2019-05-08" version="1">MPEVVVFPSPDTSSPVPQESGDGLHAYSFHNNATSDSLVTDVSVSTTDDDRVMGTLTVVSTEINKQRSAKVEQALNTLDDKVTTIQGQETLATTLYAPIKAAVALEAVSNIKQSIEDGITSFLDGMPVLMKALDEVTKLHPFIGVAVLAFKAVYTLETKRRANDKKIIALYVEMKDMIAVLIQLKVVKDEEDVGPDGVTLKGRLQGLVKKTADDMKNCANTCDAYSKMKLLAKVLKGPLWEGTLTDFGIIFTKRRTEFEFALSIHIGRGVDEANRKLDNLAQELKERTDMLLQFMQSYVPPEQRELVALVQKKGGTKAVMDNENVLKELNSYESRRPTKTGDTQNQASLGHARTSKDDFEELKSDLRHDPAAAAINNFQMFERKFAIQQRQLIEEVDRVVTRESDRVIQSVTSGPHDKVVDRDLYNVWKEMGWRGSVKARHFVLAIRDYYQEKADNKSRMESAFETVPTSDPDAWALEYLSVKWLQPIVDAFDDDASGFITVAEANKLIAIRPLDWSLLHWIAYWALGWHINALIYVDRINELLGKMFAIKGDIHAANGPYVDQYLDTVWIGVTRLTYSIRPMQSSDDIQARFKSHMDAEEERIRRNLEAIRYDIDDVETLPLITGPGRIEKNIFPLIYLLLKRDFEIMRLCRTKVVNRDELWDCADSLQRVFDALQARHDELEDIFRQQKLDLNQQFKTVCAELFDYWHDPTTFFTRSNLRSLQFPTCLYKDEEEAQDIRPEDILNYPLDEDYPYDCAAYEISDPAVETDGDHKAEGHLKALVGRWHVVLARGDEYPCQCMSVFDVHVSADGQSIEGSGKTLEGTAYAISGATETDSDGQISYRFTQKYTARFSTKCFCGHLNEECTTLQGVWGYGSADGSNDDFVMSRLAPEVLTYRPSPRQFAENRIKALWKFVLSAVEGQVRRQIWSWSHFKQRRDIRKRYIQLLIRKWDFGRLLEGDEEDELARCRKTLTPEDARFYETLYHFQLRVTPVHVGVSCDNCRGIIGGTRTVCIDCDTDATVDFCDDERCLNAEVQRFDLTSPHLPSHAVYKVRRVVHPREFGPVDSEARVALQNARAAFKDAVEVQEERTEGSAKEDDRTAKMVNDKLKCLVCKKRVRQPCWFCMTCWDVYICLDCDPKDGITIDGHDQSHPLVRCQEEVAVEESLTVEQRMEALESKFGTVDGKITQVDERLLRIEQLLQTMHLIMSASSPSTAVSSSAEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUU6</accession>
    <name>A0A401GUU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0804840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616873.1">
        <property type="nucleotide sequence ID" value="XM_027761072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUU6"/>
    <dbReference type="STRING" id="139825.A0A401GUU6"/>
    <dbReference type="GeneID" id="38782877"/>
    <dbReference type="InParanoid" id="A0A401GUU6"/>
    <dbReference type="OrthoDB" id="3363836at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="542" mass="56809" checksum="06D2F49D4C292D85" modified="2019-05-08" version="1">MKGFTKVFRTGHAVAPAHAHRQRSAPCSSGGFYKTPTAGQVIPYTTPLNISWDTSCMTSNTVDIYLYAPGSALPRIHEWANVDFAYGSYNVNLMPKWWNSTASANLQLAIVEAGTPPFLATMPAGPVFTATYTKPTSGSVPAAADTSTPGASIQNVNNGPSKSHGLSKGAVAAAVLLPLLFVIGLAVGVYIKLSRAKGRDKRKRWNEAIDKRMSTISTSWRPVSVAGATVVVRNSVLSSAANAGDRASSFSFGAMRPSSTIAVEGGQAGIGAKGLEIGGIDLSSPDMAHIRPGVRARASSFGSERVSRVSFAPDTRPSGEYRRTRAFHVGHVPPLPDEDETGALSPTQAAGPFSLSAEDIQARMSGQEDSRPSIDAVLPALSMMRTGGDGVSNNDDMLLAPSPPMPAPPSLAHQIPKSSIVGIMPMQPMPANVMSPDEMLRAYAERRTIGSPVPGGPTVPAPVANYNGTGMRILYSPTTPDSSAPLATSPMAPASPESQYTISSPKAIQELVRKSIAVTVASQYEDLDDEDAYGAVETGMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV98</accession>
    <name>A0A401GV98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617061.1">
        <property type="nucleotide sequence ID" value="XM_027761260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV98"/>
    <dbReference type="STRING" id="139825.A0A401GV98"/>
    <dbReference type="GeneID" id="38783065"/>
    <dbReference type="InParanoid" id="A0A401GV98"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="511" mass="56472" checksum="ABD0EDCBAFFFEF30" modified="2019-05-08" version="1">MSLDQNLFTLHISPNADDPTIVDLADPAGNLHYRKQLVPGNVYVINVYDPLSESLLATATAPSAISKHKTIQLHNPETIVELKSTGTLSFKWSFKWEEHEFEWRREECFIIRKPDPAVLVAVTKEPAGRLRTTSIQMLDYNLNRFDVQDRKGLEILILTALLTLHDTNEAYHTPSTDEPVSTTPLLPTAITGLLGFGTRRTPSESRGAPANLSDSASASSEAVPALPPKPAPRTGVELIAEKHMLRSMQGVGEANEVEVDSEGAVEEYAAYAAGLLKDEAMLFITVRSASAAQVPRVLRVVEETKRLRHKSGIADEEELHQYVVYDTAPAKGLRRINLDDPAPATKGKAYVPPTSLMVHLSKIDMPELRPPIETNRDLRLEVDASYNVTYTPVRDKRKMTVKEKEKLPDRKREKERRKASKDHDRGTVHHPEPNKSMRPTGSRLSPPLQNASLHAPPPFPPRGASPGYGWSPPAPTGYPSAASYPLGFAPPPPIAPRPQHPSTGILDWARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVD5</accession>
    <name>A0A401GVD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0900270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617063.1">
        <property type="nucleotide sequence ID" value="XM_027761262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVD5"/>
    <dbReference type="STRING" id="139825.A0A401GVD5"/>
    <dbReference type="GeneID" id="38783067"/>
    <dbReference type="InParanoid" id="A0A401GVD5"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="925"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="303"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="872"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1095" mass="122289" checksum="320E855F18D471F9" modified="2019-05-08" version="1">MALSLFRIFRFLRSIFTPAALIIGFSCLLTFIFVLYQPTPGPGSIQRLGWQSWDIISDAPVSGANSDVSESGGASQPTTGGQPEGVDWWNVTSPDVSSSSASLPLDVWDPLLPHDTGLTEIAITQCWIDPWYAPSVAGSMCYPGSTKEQDATKGKWVRVERNLNSQSGLMSLNVYYRRTRRHDLPVVTELRILPDRETPSPFGADWNKVAHSVNPSGHKLYLWYKMSKTLAEMSADERQNELVTEIDVLFGDDQPWYGFEKLDMPVLDHKAIVGRESVWLTYRRGVKPPPRAPPLHFSHDGRFKIMQIADLHFSVAQGTCRDTDLSPCSGSDNLTSSLLSRMLDIERPDFVVFTGDQLNGQGTSWDVRSVLAKFSRSVAERGIPWAAVFGNHDDEDGDSREAQIKYMQGLPYSLVEAGPKGIHGVGNYVLKVKSADPSMMHLLTLYFLDSGSYSKGFLNWFGFFVPTEYDWIHQDQIDWFLEQSASIDPIERPFTPDNAKDMGDIWARQAADQLTPDTRRLAKPNALMFFHIPLEESYAAADVNPDTGIPLDVGLHDLEGKGSAKKQDGFFHKGLLQAMESDHRAGGNAREVKVVGNGHCHVTENCRRVQGVWLCFGGGGSYSGYGRIGFDRRVRIYDISDYGETIRTYKRTEHNEVINEIVLAGRGLRNGPLPFARIWWRVRVQHRPFSFTANQYAEVQHTSHIPSFRQQITRTTNTRLFSDRLKFPSVRNQVLCFIYGSILVYWIAARETNVETYVWSTRLQDSGMAWKFRAPTNDEMRRARYYQFGKSLQAGLASLNTIVKEWPQTIKGIVTWAYVQVAQPILDTSEGRRVCWGIGAANTLVWLAWQMPRMQPLLTRSFVHNPMSGLSYTLFTSIFSHKSIIHLFINSMALSAFGAAVSHSLAKRQTENPTYLREATVRWHFLAFFISAGVFSGLVSHVVAMRFIFPRLVSRLSASASNTAPPGSLASASSFASAATARAVTSASTTVASSHGASGAIYATLALTALEYPDTEIAMAIPPTFPLPVTWGVGALVAVDILGVLRGWRRFNHWAHLGGVAFGALYHAYGPQTWEYCRLITLGRMPRSLSKQKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVM2</accession>
    <name>A0A401GVM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0901350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617169.1">
        <property type="nucleotide sequence ID" value="XM_027761368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVM2"/>
    <dbReference type="GeneID" id="38783173"/>
    <dbReference type="InParanoid" id="A0A401GVM2"/>
    <dbReference type="OrthoDB" id="2797568at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="181"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="509" mass="57105" checksum="D25CB1AF3CED6D83" modified="2019-05-08" version="1">MNSLSCSATPSSSCSSPGRRPKLPTSIMDFHTPNVQEQREAVSLPVAKHPTETWGLWNNETLLRINEFVGDVDTFLKVFVPCNEPCPVPSRKEAISGAFLPLVGIGNELEMYDPLIQGLELITSEFPNKKPLEFCNTSRTDFHFPFARWGTDHHITRPDVVALVANVSAGSAELDKWRDSNVSLVFEAKAKESEDPVLSSSEEHIKTRIQLSRNARNLMLAHSNLYCFVIGIYERIAPIFRFDRESAIVSPPISYQTDPTKLREFLWRFVHPAYSDGVNGMDELSVRATGDCVRWAQDLFTSHGQPLTAEDLEHNHLVTIPPTTVDGESQIYFTLRLRAVKPNLFGRCTVVQEVVRKSDEGADATRYILKESWRQDIRPSELEFYERIEEHIKFSEKRAAQEGEKFELVGLARMVRGVDLGALELSKLERRMGRTPSALFHSHCMEDTNPQSSSLSKAIATLPPRPPQMPPPKKRQADPRKVPLVGATSQDSISLPDAVVTLSRLPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW52</accession>
    <name>A0A401GW52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0805180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616907.1">
        <property type="nucleotide sequence ID" value="XM_027761106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW52"/>
    <dbReference type="STRING" id="139825.A0A401GW52"/>
    <dbReference type="GeneID" id="38782911"/>
    <dbReference type="InParanoid" id="A0A401GW52"/>
    <dbReference type="OrthoDB" id="3003917at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="96"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="486" mass="53909" checksum="EEBB5B3FF534E51E" modified="2019-05-08" version="1">MPLMHFIPALLRIVSHPKSPLDPAPSSSLPSLHTLLQPLLLTPRSSSEKYQSHICQILADDGGAGDAEETMMWYALRYEKMDDERSAKLSDDQAPDADEEKWRHTWLGGMERREVQIQILLHLLLLSQSGPSQPGEVEPVRAEIPVQLMLSPSKRKRKQRDPSLRPLPLEEGLEFFMDKLSMWQLMASLEEEDAKRHVYGKGKQRAVDDRDWIQVFCEDIVEPLFKDKQPDLCALLHTKVFQASAFSDDADSFTFSPSPPSSPRLKPAATASSQSSHGRNPPPQVKTSDRLRSRSLSVSLEQERSRSRSASVDAAGLRKRMFAREVSMSTVFKGKNKDSKTKASTARTRVGRAPQEKPAPVVKEKRKGRESAFGMTLVAATPTKPRVKSQSQREAALAQPAFLQQRDRARALRLKPLAEGPVEGDGSNDQWMLPSSPDVLLMGPDGDDDTSVLGKSAKGRRDGAGSRRMGSLLVTSTPTKKARIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXN8</accession>
    <name>A0A401GXN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1002080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617876.1">
        <property type="nucleotide sequence ID" value="XM_027762075.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXN8"/>
    <dbReference type="GeneID" id="38783880"/>
    <dbReference type="InParanoid" id="A0A401GXN8"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17936">
        <property type="entry name" value="EEXXEc_NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001660">
        <property type="entry name" value="NF-X1 finger and helicase protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000159">
        <property type="entry name" value="p-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000160">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="490"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1347"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1626"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="1906"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1256"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2159"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1172"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2217"/>
            <end position="2320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1256"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2165"/>
            <end position="2175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2354" mass="263070" checksum="0EC9EB5BCC04CCF9" modified="2019-05-08" version="1">MNPQKNSNNNSNPRAHKLNRLFDSILNGKQSLTPQNGPLFLESICAQADPATCVNRLIAASKTGLPSLQAAMRYDLSVSFANGLATTVITYMQAPGLETIAGGHFIQQIVAAIVEPPIFWNMFSTAFQAGELQENGRHAFGWLLLQLISLPGDRGSSYRELTQDEAILDRLSISSRPDTKALVQKIRNILATFNNPIPADSGESVPGGRHDNDFVDFRDICILPTADEITCTARPFLRPSSALDDPEMADNRTAVYLDNLFRLLREDMIFDMREELQLAQGKKKGKRRGFFIDGMTPLGVYCGTDKKRVKWGISFECESDLPQFKGKKKEKDRKAVLTDDKKVLRHQALSCLLVDDEVVAFPTVNRDEDLLVKVPPIIILQFEGEATTTKTLLKLKTGTRIKLIQIDTAVFAYEPILKAIQGAKEVPLSEEILFWNEESSMECPPAAPMHIVDALRRDPHQDLRALLQIQQSNPIKLDKSQAESLLASLTQRVSLIQGPPGTGKSFIGALLAKALYDSTGDIILVVCYTNHALDQFLEDLMNIGIPATSMVRLGKASNSQTEALSLYKQNRDFRLGRTDWQEIDGYRTTTTFLAAHLDASFDKYISSNVQDHELLEHLEFEAPEFYQAFYVPNSNDGMTQVGKKGRAVDSVYLLRQWQKGWDAGIFKQAPHVRAASQIWEMTPAQRKSQVDAWTEELIKERVGEIYSTAVNYNEASNNLDRKFNQHVSVTLRSKRIIGCTTTAAAKYSDDIQAASPGVLLVEEAGEILESHVLTALGAKTKQLILIGDHKQLRPKVNHYLLTVEKGEGYDLNRSLFERLILKGYPHETLSQQHRMRPEISSLIRALTYPDLVDADSTKNRPNIRGLQDDIVFINHSFPEDDLPQVADRKDATSTSSKQNTYEAEMVLKIVRYLGQQGYGTDKLVILTPYLGQLHKLQAMLRQDNDPILNDLDSHDLVRAGLVPAATANMSKKRIRLATIDNYQGEESDIVIVSLTRSNSNHDIGFMFSPERVNVLLSRARLGMIMLGNAETFMQARRGKELWTKLFDLLKRSNRVHDGLPVKCERHPTRMALLKRPHDFTDLVPDGGCQEPCGTLLNCNIHNCPSKCHQLYDHSKMRCESIMKDTCSKGHPLSWTCHEGRPPACKKCERETKLAEEKQRQAFALQRKREEDDRAHAAELKKLDEEIAQERQKLRDEQLAQERANVIQQKQKDVEEARSMSSRVVSSIQTVSATLSLGSGSSPHAVGPIAATTAAPVAVPRSPTTHSKVKASAESKPPASKSQPTQQTPSPSESEQEWERQKTMEGASNESIDAIMHMTGLEEVKAQVLRIKDKIEITQRQNTSLKSERFNIVLLGNPGTGKTTVARHYAKFLTSLQVLPGAAFVETTGSRLANDGVAGIKKHIEEVINAGGGAIFVDEAYQLKSEHSFQGSQVLDFLLAEMENNVGSIVFILAGYSKQMEKFFEHNPGLTSRVPYMLQFADYKDSELRLMFERMITKKYNRQMELEDGFEGLYSRIVIRRLGRGRGREGFGNARALENLLAKIGERQAARIAKERKKGPHPNDFLFTKEDLIGPDPSQVLIDSAAWKKLQKLIGLTEVKESIRNLFDLIDSNYQRELKEKDPIQMSLNRVFLGSPGTGKTSVAKLYGQILADLGLLSNGEVVLKNPADFIDSVLGGSESKTKAILASTVGKVLIIDEAYMLYGGGPSGTGSQNDPYKTAVIDTIVAEVQSVPGEDRCVLLLGYKDQIVEMFQNVNPGLARRFAIENAFHFEDFNDQQLLEILQLKLKDQDLEATDEAKAVAIDLLSRARNRPNFGNAGEVENVLGQAKARYQTRHASLPVKQRRFDVVFEPRDFDPDFDRGARASSNLQKIFEDVIGCEDIVAKLGGYQDTARRMKARRMDPRDQIPTTFVMKGPPGTGKTTTARKMGQVFYDMGFLSSPDVIECSASDLVGQYVGQTGPKTQKLMEKALGKVLFIDEAYRLGEGHFAKEAIDELVSVLTQPRFLHKVVVILAGYDQDMNRLMSVNAGLSSRFSEEITFVNMAPARCLEVLKKGLMKKNVYLNDLDNPSSDTYQELEALIQELSNLPSWGNARDVGTLAKQMISHVFTHLPDSDPPNADSRLLLSGTDAVACTKSMLTERRARYINVGPAEPRSPLFETKQQMLNPPPPPPPLPPSTRTASSVKTAPDERRENRSGPSQSEAQQRDPEVSDKVWLHLQEAKKAAEFEAKRAAEEQRRLEQQLQEAKEHEEAVQVFVRKLAEARAKDDAEQAELKRKLEEVRLREYRLKVERERREAALKAKMEEEARRRKQEAMAQAKLRKMGVCVAGYQWIKISGGYRCAGGSHYVSDAALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY23</accession>
    <name>A0A401GY23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1003540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618020.1">
        <property type="nucleotide sequence ID" value="XM_027762219.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GY23">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GY23"/>
    <dbReference type="GeneID" id="38784024"/>
    <dbReference type="InParanoid" id="A0A401GY23"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2117" mass="235541" checksum="77F10E529EC1F1E5" modified="2019-05-08" version="1">MASVSDLRNMLLSAFSPRGLQDGEQEFFEMLIARRPQLVNLYNIGPRSTQEQRELESGKITVDGRPLAVNTDFARQTVFLSQQLDCSERYIASLLQDVVAENPNMTRERCIEAAVLEFHVRRRQLAECLRYIFEAAEMVESQDAPPLCARIDLFVRQQLLPAPGGPAGGLSLASKIFQEVHNLGNVLSKAQTARQNARSNTVAPSAQTNEAYLGADILSARCDSIRYERRTLAVVLFLVSRMGLLTPTEIQKMVDWLHGNPRHAMTYYVLPTVLAAFDSVDPASAGGQARRTVAAEKSFVSYMKRKLDVATEWKEPGLKATILLKWTLFMTETRRRDASLENTAGFRTEELETQIWNAVQGDCFTYVLRMVALVQKQQGEQPSTSYSAALLSQIEQDAPPELPAEDFRPAVLEGCEALVRSLITQASSELRKIKQRQEDLLLAGSRTDRSRPFRSSMGQSQHLSSSTPPEMDKSNSPPRNDMAILFSLVGLLYSTLPPERALHFWGSGGMLEGKRSSYTEFAEANSGRLPAFLQWAVWSTQPRDIDMSTALYDMLSGLAKGQQCSELAYNFLARGGGEVMGGSVSAGPPHLATGPTVSWGSIFGLLDSWATAGSASRSAQQPPEGQSPQSAFQAPQWQAQQAHQHQQQLSFSSQDVLFAQSFLRLLATVVTHSVAVRVTISGHARFRAIPTLVSLITISIPLELKGAIFDTLSAFCLPGAGSPGVEICKSIWTLMERLEVINVRMAPGSSIPAVKGVEVELDEVETAYKMYPSTIPFLRLLSTLIHTPKSVVLSDRVADAEPINTIPDGLGQPYRTPGIGPFLSFVVDNVFSKISSREYMRPVDRWRTNDLCLCFMERCLASYDLESLVTSVEELQPKGDAILQLAAHPGYEIMRRMLTPSPLQNSILSYLVEGVDGFDRGLAEEEAFFRSTIVRVLRMIHRILEIQDIFLDVLVPMLSEIKDPTIIGEVHPASYFVRFDQVLSYSRQHVPAVATYIAYPAYPELMLLSVKILTALTSSSAFLQLALMIDKSEESVRILDGFQNIMDADVLDDVETAEIIAEQNTGAGAPDSDEPLASITQAIRVAVLDLFIQNTDIDRPYPNIAHFLLFGGATDRDQIQDPHALGARRSCIHSIIDILNTGVPRLKGKSSGRLSSIDPLFISLPALAERCYHVIYQLCKHPQTSEFIMRYLRTREDFFARHLAALPFKIAGADVESFIEVMYNDGSRVTTTVSALASFLRLRSWILDLVALELHVLTNKGHQKSVSELLELLFGNEENQPEDEGVWDSDVFTPFREVGQSHLRMIEFIQSLDFDWSDSLSAQPVELQFLAQLNLQSCLRVDGAGCEVIDRTALLSILTLAQRELHAQGRILNPTHYQQLIAEMNYIMESCAIENHRREIRYAAASGYEAWRRLLDMSLMKCFDRLPYDRRENMLFDLLHVLPQSLRSANVQPSSAVLLSEAVLSTITKLREDRRYQVILQSAGGDVEAGSLPAERLYALLRSLLDCIMDNNRIALVRGNLYASLINYFHLVIAPKVLQEIETGPINLVASLSASSLSREDSLFNDSMSSVALSIQTCGSQQTGSILMNGSLIILKSVMERLVAIVSRDAIDGSEVWKSVAFMLLDSLVRLSRLEKQSVIIHTLARHGFLSGFVRGLKESDLRLQDVLKPDPDELNTLYVYEAKMSLLVRVAQSRQGAERLLEARAIPVLAECDYLDARPEADQAFLDRDNFLPSAVQRYHQLFTPALQLVSGMLITLGTRHITAVNQALQFLSSRRDTAVLLLKNEVDELSLAVLEELRLLVSLCSNVVQHIPKTELLSNIGFGGIHAAISNLAARCLGNRHWTESVKPQTERELSDAAVVEPGYGSETKFRVAVHRKDQLLREAVVAYLGTACDFTEPEFTLVLSPAVNTPRQEDRSSRFLATVPTMGDAIEALYSFCDELAGTLKTIADLSAELAAKDYIRVDNIQEIVSVPDQGLLDNLNIRQKQSLVSRELTHWRAGATDRAQVTITSLEMLLLLLWRHLLFYSEGRHINNPDLKGSISHMMRLTSSPDVDVIKAEAARKLMPVLQRMQTLDLTEETIGEDWKSYQSYIAIMARRLMDVAGLDEEPEAQIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYI2</accession>
    <name>A0A401GYI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1003010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617967.1">
        <property type="nucleotide sequence ID" value="XM_027762166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYI2"/>
    <dbReference type="STRING" id="139825.A0A401GYI2"/>
    <dbReference type="GeneID" id="38783971"/>
    <dbReference type="InParanoid" id="A0A401GYI2"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="536" mass="58964" checksum="DCFAC1686155C4AB" modified="2019-05-08" version="1">MSHAAGPSHLDEDERMSGKDRDFGLTETYSDLGEEEEQEEGDGESDGDNRSEGEEDDIDEGDTDQDDIDDTQPYLTRSPKNMKGKGKGSVYSPRPSAVDRTQSSSSSWADLDLSVIVAFVSPIGNWLTGGDHIKNLFLIILLIFYLHQLIEIPWRLYQASLPHKPSHPANPASTNPQTARLVALARTELHRQELFYLVLTVVSPLLGAAFLQHIADALGGTQALSWFSTTLFVLATGLRPWSHLVARLRDRTNALHNAVHYPPPAESEAAATAAAQERAFGKALTRLSSVERQLADLRARAARGDKLQGVCDDLSEAIGDIERNAKRGERKSDSTRSELSARIAALEAGLLQVEERRRKDIERFKAGLSPLPPAYALTFARAHNYVSTIVGTLIRMPKTLWSLGMKELSPEKPATSPQATGRTNGHVTSPIIREGTRHAPRLATIPEAEHSDADSDGTYVSDPEKERDKEERMRSRSRSHSGGSGRAAKAKARARSYSYSEKGFEVVQGLMLWPYRASVRVLVAVMPPVKKILPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYM0</accession>
    <name>A0A401GYM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1004990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618165.1">
        <property type="nucleotide sequence ID" value="XM_027762364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYM0"/>
    <dbReference type="GeneID" id="38784169"/>
    <dbReference type="InParanoid" id="A0A401GYM0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="86" mass="9729" checksum="40F3850F3EFA7621" modified="2019-05-08" version="1">MMRVLDEDALGAEVPEDTEDMEDAPGVEEALDEAEVAGMLEPEDTDGYAGEVYQRSSCSERKTRERSTRRNQAGRGGCWSRWQRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYN8</accession>
    <name>A0A401GYN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1005180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618184.1">
        <property type="nucleotide sequence ID" value="XM_027762383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYN8"/>
    <dbReference type="STRING" id="139825.A0A401GYN8"/>
    <dbReference type="GeneID" id="38784188"/>
    <dbReference type="InParanoid" id="A0A401GYN8"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="289" mass="33237" checksum="57FEB7C43F338DF8" modified="2019-05-08" version="1">MTPLRDDPLSSKADIVTEPCQWSPNEHIHLPAPEEVFSAPVLSKKDGSVVAKVTELLVVKYGRRVFPREVAAIRYVSAHTSIPVPQIRGTYKYDSQFFFFMDFMPGRSLDEVWPEMTPAAKSILVEQLRDHYSRLKSLTGTYIGGLGRTPAFDIVFENLKSDDRGPFSSVTAFHDALYRAFKVCIDRNSPDYPAFLVRGIRRMLKDNYAVHFCHGDLKPRNVVVSEKGDLVSVLSWGRAGFWPAYWEWLKANDRAWEDARGWPSVLDSVLEPFDREYWIYFKCFQEPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYP7</accession>
    <name>A0A401GYP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1005270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618193.1">
        <property type="nucleotide sequence ID" value="XM_027762392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYP7"/>
    <dbReference type="GeneID" id="38784197"/>
    <dbReference type="InParanoid" id="A0A401GYP7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10965" checksum="EC38534D1AE6BD65" modified="2019-05-08" version="1">MDPNTDMRDATQTAFPVKKGASAPLLPAPCTTAVYCVNSPSGLRPLPKRSGFKRLLRAFLSISFAIILFSHLAKLVPHVARMFHDRRHSLGPDMPPTDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYS0</accession>
    <name>A0A401GYS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-dependent bile acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1005490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618214.1">
        <property type="nucleotide sequence ID" value="XM_027762413.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYS0"/>
    <dbReference type="GeneID" id="38784218"/>
    <dbReference type="InParanoid" id="A0A401GYS0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001354">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="996"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1129"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1261"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="316"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="673"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1011"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1326"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="920"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="951"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE87301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1588" mass="176128" checksum="7C7A97B158B08756" modified="2019-05-08" version="1">MWQYQLEVAIVLASTAVCSLVVFLLSRLREGKIQLPESIGTDVALRNDPFDVTELEDLIDGIPVDEARFWSQMLLRKLIMTVTLVVVLVVQSVFLGWAIVENDGLSLVVYSLHVCVALYAFLVAIRSISQRDDLHAQSVFHLFALTFVATLLLGTTAVLPSRPSLHASFSGDLVGPVALWYTAFLLYSVCFLIAVTTPVGPPLHYPSEKVYSDKTLMLVNTTAEDNVCGITGASVWDTFFFSYTTKVVMLGNTAESVEIADLPIVPANMRATNIYSDMRAAIRRWKLRIRNWQPKPGSGWELGYRLLRVNTYLLSLVIALSSVTAVLFYVPAFFLQRVVSYLESDPLRTDRGWGWVYSAGLFFSNAFVHLLTGQLWSLSTTNLQVRLKIQLNSTLFAKTLVRKDVASSAPPASTTENGAATNGSADGKSEAKPEEEDNFSSKAQIMTLMTTDVDRVSEFAWHLFTLIDSPIEVAIGTIFLYNLLGVSCFFGLAVTCLFLPLNHFAGKVIVGAQDKLMKARDERVGLMNEILGGIRMLKFMAWERSFEARVMKIRARELKYQQLNYHIEVLFSTIWSASPILVTLVSFWHFTVIRGQVLTPSIAFTSISVFNEMKFALNALPETFINMLQSLVSMRRIEKYLYGAEIDSVPPLDGLSHPIAFQSATITWPQDRTRSSSAATTAASTPKNKFVLMDVTLNFPLGELSLICGKLGSGKSLLLLALLGEADLLTGQLTCPRSPPDILASFADADVREEEWIVPGVCAYVPQSAWLRNASIRDNILFELPYVEERYQKTLEVCALLSDLRILEDGDMSEIGERGVNLSGGQKARVSLARAVYSRASVLLLDDVLSAVDAHTAHHLYYECLKGDLMRNRTVILVSHHVQLCAPGASYIVALDNGRVQFQGDRGNFKASGVLNTLVQSGAADPSDEKEETTTVNIEEVMDAERKDVSGEASEASSTTALTSNDVESKPEQRKAPRKVVEEEKRAVGRISNDIWMTYFGAAGGLGYWSLFISVMLLATLGPVFENGWLRIWTAAATETENVRTPLFYVCTYAAITTTVLIFWTVRWVVLYHGGIHASTELYKRLLECVLFANIRFHDTVSRGRLLNRFGKDFEGVDSNLPDNFGRSVAYGLSALTTFVTISIVGGLPFVIAAIVLGILYYNVGKVYGQTSRDMRRLDSVTRSPLYSMYGETIAGVTVLRAFGASSKFLRDMLRCVDTNANPYYWMWGVNRWLSARFDLLSSAVVGITGFVAILNPSISASLAGFTLAFAFTITSDLLFLVRRFVGLEQSMVAIERIKEFSELKREPPEFIEPRPPATWPAHGAIKCENLVIRYAPELPNVLHNLNFEIKPGEKVGVLGRTGSGKSTLALSFFRFVEPTEGRILVDDVDISQLGLTDLRSKLTIIPQDPTILSGTLRSMLDVFDEYDDAEIYEALHRVHLIPSSDTPAEDEDAVNANVFRNLDSPVSEGGENFSTGEKQLLCMARAILKRSKVLLMDEATASVDYATDELIGKTIRQEFAESTILTIAHRLRTVIDYDRVMLLEQGRIVEFDKPRTLLADPRSKFHALCRATGKNEFAVLKKMAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H016</accession>
    <name>A0A401H016_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1104190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618655.1">
        <property type="nucleotide sequence ID" value="XM_027762854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H016"/>
    <dbReference type="GeneID" id="38784659"/>
    <dbReference type="InParanoid" id="A0A401H016"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32538" checksum="6AF7F8CCD91A855B" modified="2019-05-08" version="1">MASRPRNISLHLIRTSDQELMLYNFTECLETFQLEINHTSLYGLNADMIWPRVTTLRIHASESFQISHLARAFPNVQHFKCSHPLPMLPDLHPHWSYLDEVDTSSPIELYSRVRRIRFRYDRGTEPEENNRVALAMLQRASPVILKCEVHPEVVERIPEVAPDLKHLTIFLRDGRGELIDLVVSAQSLTTSRALRKLPLVALSVGLCTQSPLYDVPRLRDTAQRIVVALPTLEYISFDTLDSLGFPRTCCWFRVTTRGVCLPQLNVLSQAEIGVVESELLSLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0V7</accession>
    <name>A0A401H0V7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618933.1">
        <property type="nucleotide sequence ID" value="XM_027763132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0V7"/>
    <dbReference type="GeneID" id="38784937"/>
    <dbReference type="InParanoid" id="A0A401H0V7"/>
    <dbReference type="OrthoDB" id="3355886at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="208" mass="21659" checksum="FD2AADFF226FB31B" modified="2019-05-08" version="1">MSAFRSIYKLSRTLPSTVRAFHSPFASLSSPLTSPPPPTANVSPLYEKQTEPSPEPQMSGAGTRTYVVSAPDPADTPYEVPSGAYPTSAPYQSYPGTEAPVLEGEHFSSTSSTLAHPLTTTAVPQNPTGVGESAAVRHSEAPGELHRRGGSFGGLGLMDAKTTTQGKGALAERNLPPLDFAGEEHPKLAVDNITTGKGAGVSGPRCWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1P6</accession>
    <name>A0A401H1P6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lanosterol 14-alpha demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_1301430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619241.1">
        <property type="nucleotide sequence ID" value="XM_027763440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1P6"/>
    <dbReference type="FunCoup" id="A0A401H1P6">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1P6"/>
    <dbReference type="GeneID" id="38785245"/>
    <dbReference type="InParanoid" id="A0A401H1P6"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE88328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="602" mass="68025" checksum="23273AB6E5C4332E" modified="2019-05-08" version="1">MLISVNDETWWRDKWTRQDLECGDCRPGSAAIYGSAVLYSTTLPLLVFHLRAATSTVAMSLNSTFAEPLAGYLAQAQNYLPPTPRLLVIGLLYTPIAFVVLNVLYQLLPSSGSKPQVVFHWIPWFGSAAAYGQDPVSFFKECREKYGNVFTFILLGKRVTVALGPQGNNFVLGGKHTVLAAEDVYGPLTTPVFGKDVVYDCPNELLMEQKKFVKYSLTMERFRSYVGMVEDEIVEYFRTDPQFRIYQMNDINEWGAFKPNKVLAEITILTASRTLQGKEVRDNMDKGFAELFHDLDNGFTPLHWMFQNLPLPSYRKRDAAHAKMSTFYEQILRNRRATGEDPDDVMSSLAKQHYRSGRALKDHEIAHIMIALLMAGQHTSSASGTWAILRLAANPDVAEQLYQEQVKLLATPDGRFRDMTYDDLRSLPILDAVIRETLRIHTPIHSIMRLAHSDIPVPQSLAAPSENSVYVVPKGDIVLASPGLSQMEPSVWKDADTWDPSRWYDQDGFAAHAQKTYDEDTKVDFGFGLVSKGTDSPYLPFGAGRHRCIGEQFAYLQIGVLISTFVRHLELRLEGEFPKPDYSSMMVSPFPCEVAYRRRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2K6</accession>
    <name>A0A401H2K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619545.1">
        <property type="nucleotide sequence ID" value="XM_027763744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2K6"/>
    <dbReference type="GeneID" id="38785549"/>
    <dbReference type="InParanoid" id="A0A401H2K6"/>
    <dbReference type="OrthoDB" id="10496941at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="311" mass="35394" checksum="87ED9C3693BDC68F" modified="2019-05-08" version="1">MDTFTFDIPAILAGDTEPQTNVLVQDIYGPNIADRKPVQLLPYHVQHYNHNMQRWMAVVAAAHDELMRGFQYQINAEAKLREVMLSVDDFCFYNDRSVDLAGECSTFWDPDPEFNQMEDARTAITDKTPPVEWSDSVGLDLSLFQKHAYQMSKHSEALSSLFASFIAVPISLSRDDINESRRTPLYARRDGTATNEIARAMEDVMPSDANNEREARQLKLEPAKWSHVLLGSDFGPRLFNPGTPDRRLYSETSYDFDIQDDDMKGPGCAPSRSLFEILNISEGELYDCSEDELADCYHGHPERPQPRYGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H375</accession>
    <name>A0A401H375_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1402860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619791.1">
        <property type="nucleotide sequence ID" value="XM_027763990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H375"/>
    <dbReference type="GeneID" id="38785795"/>
    <dbReference type="InParanoid" id="A0A401H375"/>
    <dbReference type="OrthoDB" id="2804045at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31254" checksum="9BA538B83D3BEF72" modified="2019-05-08" version="1">MRIDSLLSPTSKSCQATGTLIPVFQELLVLVWAGFLALRTYAVGSGAWKSAAIVFALSMVPAGTDLYVDIKTNSYTHVVLPSFGNACWNTSYLSGNLGKILVIVTRTSLIAADLVVLFVTWSSTYRIKREADRVNMEASLSTLLLRDGTIYFVLLVLLNIAHMTCYLLSVWLDVSFFVNSFSAVIISRFLLNLRQINQPDDNEVDNPRPSFVASHASNLGFASFVGNMGEQLDFNASVDIASADRLDFEEGELNCPSDISEHGTHDELKDMHVDVELVSAGPSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H483</accession>
    <name>A0A401H483_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1502210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620126.1">
        <property type="nucleotide sequence ID" value="XM_027764325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H483"/>
    <dbReference type="STRING" id="139825.A0A401H483"/>
    <dbReference type="GeneID" id="38786130"/>
    <dbReference type="InParanoid" id="A0A401H483"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="418"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="482" mass="53256" checksum="D20D8632D04C9C6F" modified="2019-05-08" version="1">MSQHSLPLSATDVESDPKFLPTPVDMSYDDRTYPYQFAGHQFCHSPDRAAPGGSPVNCSPSHNVAHPDFYQEGRLIFFDQAHCGRVDPCGADSFKWTKHGYENFLPGHNGIWPHWQEYQEGSLLLQRLSSHEELQLSCISTSETPQGQQTVDGRSSATVSGSVRAFRDHVLNSSYSEASRTPCYPSTSTVSDSQILSDSPAEASTFFCVPVNAQLPGEAYAQYYSGSGLSLSLQHTSFSPCPDVPAGFSGSSDYSNSQDRSHVPAYSQPGFLMGRTRCDDNLGHCANKDSTDRWAASSYDHRYPYPQSLANYPTLVSVQSQSEPIPQPSEQRRYTVALHNSPPCAYSYPRFTETESPLSSHVHAPQPHPWPMLPPPAVAEDPSLAIHGSMHSGVSSAPTVTHSLPLVEYNPKKPLTLACFFCRRRKIACVSPLPQKKDRTCNQCAHRSLKCVYPDVSRRGMRQKLLYNKDPIPVVPPLLHVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4H9</accession>
    <name>A0A401H4H9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620258.1">
        <property type="nucleotide sequence ID" value="XM_027764457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4H9"/>
    <dbReference type="GeneID" id="38786262"/>
    <dbReference type="InParanoid" id="A0A401H4H9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="100" mass="11057" checksum="4525CCA835B96353" modified="2019-05-08" version="1">MIYGPYIMRDISSVYYRPYQKAKHSRAAAFCSESRTVGIEHAFSSPAESGLNINAGCVLIGRQRLPLPSRFPLASMISSFSLHMVSTYGCLYHRASPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4I8</accession>
    <name>A0A401H4I8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1503420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620247.1">
        <property type="nucleotide sequence ID" value="XM_027764446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4I8"/>
    <dbReference type="GeneID" id="38786251"/>
    <dbReference type="InParanoid" id="A0A401H4I8"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="37"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="40081" checksum="641A9E64F8FFCB21" modified="2019-05-08" version="1">MPGAYVRSQPRRRTETRLPFPCEGEPRPDAEFWFADGNIVLIMDCTAFRVHQSVLSRHSDIFRDLFTIPQPADTETMFGCPVVQIYDPLSDIRLLLRVLYDGGRHCLEHKPELEFAIVDVLVRLGHKYQVEDLRADGLARIKRVFTDNFDMWDSHSRSGKMGTELLRLTRLDAMSAVNLARIANAPSLLPVALYYCCQLDIYELCRGVPRADGTTERLSSEDMDRCIDGMSTLAQKCASGAPLKLAWKYARCTSYGRCVEIKRELLVKLQGAEKRFDALAPMDDDIDWLCATYGLCEECKQVMKTKHLKYRRRVFKELPSYFGLVEWAQLRAAEAASRVTDDSRCNFRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4K5</accession>
    <name>A0A401H4K5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1502880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620193.1">
        <property type="nucleotide sequence ID" value="XM_027764392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4K5"/>
    <dbReference type="GeneID" id="38786197"/>
    <dbReference type="InParanoid" id="A0A401H4K5"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE89280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="580" mass="61739" checksum="35D12F1E4061FF17" modified="2019-05-08" version="1">MECQNCELKQRQFYCESCLRQHLLSFRLQTNHLATDRDAHIASAQRALVTVVDPARLIRADLKGTEERVRELWEGVDEVRKVNEKTRERLRNRRSTFSARRRTIAIASSTFNHPPTPSTSASPPQAFTPTPPGSYPSSHDLPHSPVSTSPQSSRPIVHRRGSSSSSVPGSSTIVRPAMSGSRTAQPLPSRPTLSILLTSPHAPLGVSSPIQTRPGYAASNKSADSLTRQIDEATYQLAALSDTLARARSGLVQELVEVFSIVEVGGRPPLGGKAGTKGEWTIGGLVLPVPGDIRRYPPDHINAVLTHTLHFLSLLAFYLGIKLPFEVIWSRSTTPPLPSSSNSSSSSANLKGNGLLGVGIPWLGACKGGESGGWARWSAKHPLHVSSSSPATPSTTAAPPTGSNDRASRPGGYPRPASKSSVPSSSSSAKSTPTRSNALSASLADSQLEDLSGTGVGAGTSTHNSSFTTALAMLLYNVCYLAHTQAVDVPLAQAGEVLGNLWAVCCSQELGRKSHETHPLLPAPTPPSFPLDFAQLLQATAANPTRPRARGTTGRETHHAERIVEEDEDGWDLVDADGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4L5</accession>
    <name>A0A401H4L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1600470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620299.1">
        <property type="nucleotide sequence ID" value="XM_027764498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4L5"/>
    <dbReference type="GeneID" id="38786303"/>
    <dbReference type="InParanoid" id="A0A401H4L5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="213" mass="24529" checksum="C0B3474456F6E529" modified="2019-05-08" version="1">MFYHASEDLVYWKTLDRLVLPSLRETHPLGPVRRVDVLSCFDYLEGPDTKDPVTLLTQLSPVVFCCRVWRSSLSFYPVLAKTLHSLRYLDLTIKTEGKQYWDNVDGPSEEKLLEHVRAHVDRVCSCRFALTGMRIRVDAWDCERVTADVLLRMALHAARILISLNYIGVGGISTNWATWYRVWSHDGEQPVLEALPARDAVKVERELLDTQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5E4</accession>
    <name>A0A401H5E4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type II protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1602740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620524.1">
        <property type="nucleotide sequence ID" value="XM_027764723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5E4"/>
    <dbReference type="FunCoup" id="A0A401H5E4">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H5E4"/>
    <dbReference type="GeneID" id="38786528"/>
    <dbReference type="InParanoid" id="A0A401H5E4"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="591" mass="67351" checksum="811A6037F43126C5" modified="2019-05-08" version="1">MCVARATAAQTTLTTPSSVASEAHRKAFPHANIRRKNSRLLHKADRAAKLLGDRSRELLHYMTPLVAPGSRRLAQRCTRPLSARFSTTARAHNGSSSRKKTPRDHLNYNPQISFSDTPDPEHVNYRRVTSNDLEEESDPPRRVKMLVRDYIENSLYHPHYGYFTKQANIFSTPQPLEFGALRSSIEFQAVVAKRYAGYGRGSVGPGVQLWHTPTEIFKPHYGNAIGQALVSEYLLKYFPYEDFVIYEIGAGNGTMALDILNYVQAEYPDVYDRTKYNIIEISDNLARIQREKLSAVHPCVNVMHKSIFHWNTREPAPSFFLAMEVIDNFAHDMIRYDLRTLEPYQGLVTIDGNSDYSTYYTRVTDPLISSFLALRRRLMHAPPIPRLLKASSTFRSFYTNLPFAPNLSAPEYIPTRLLSLLRTLRRHFPRHHLLLSDFSSLPETIPGVNAPRVQTRVGDEMVTCGTLLVNPGYFDIFFPTDFERLRDLYEHVLSEPLSMSASESPPRASPLSTTSSSLFVGTDFFSSYHPRNRRPPVDDVASASGLPVGDRKSRVLTHEEFMETYADLSKTRVRNGENPLVEFYKNVKFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5U8</accession>
    <name>A0A401H5U8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1701410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620729.1">
        <property type="nucleotide sequence ID" value="XM_027764928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5U8"/>
    <dbReference type="STRING" id="139825.A0A401H5U8"/>
    <dbReference type="GeneID" id="38786733"/>
    <dbReference type="InParanoid" id="A0A401H5U8"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="97"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE89816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="470" mass="52650" checksum="F6FDCCF5AA406724" modified="2019-05-08" version="1">MSHLLQSLRHLRHPHPAAALRTAKSLQLVRGLAQLAHCKRSLLPSCVPATGGATMHHMASQPVTDTANWVDREERLEDYGPRGYHPVSVGDVLGSRYRVQRKLGWGVYSTVWLVRNERYVSSSEAAVFLFDCSAASWFFGSAGPSDPSFRTALATGAPELHELEYLLRIHNEPTQHPGRVHVIDLLDHFYIEGPNGKHLCLVTELLSENVYSFSTNWKDERMPIPLVKRITRQVILGIDYLHNACELIHTDIKPANILIALPRGGFKPSSAGVEVYVQEGPGDRSISRFRSNPLLFPIPSDLNSESAWSAFEVKLSDVGVACWADKTDEHFTPLIQSPSLRAPEVYVGAGWGKPADIWSLGCTVYEMIMGKSMIRAGTQQESIPFLHMVLFGDYPRNIVERGKYSHFFFNADGTSKFDIPRRLPLAMQIQGRGPPQDADMFVDFLNLMFKLDPAERASCEELLDHPWLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5Z6</accession>
    <name>A0A401H5Z6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1701570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620745.1">
        <property type="nucleotide sequence ID" value="XM_027764944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5Z6"/>
    <dbReference type="STRING" id="139825.A0A401H5Z6"/>
    <dbReference type="GeneID" id="38786749"/>
    <dbReference type="InParanoid" id="A0A401H5Z6"/>
    <dbReference type="OrthoDB" id="2689725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="987" mass="114188" checksum="AF167926559A9D8F" modified="2019-05-08" version="1">MATRTLRVASKVMKQKDILRQRDTMREVVERSVAGLSGESLQLLSELRGEEFADSETSRDVNESAMLPIEGDDQMDWETLPDDAEGSFAHAVRDIICSRWKTRWYKDTRTWRLRLERAQANWAPLISSLTDLYLSWCHLPLQPCDSPLHHDPEACSQDDEDYSFTIEVIDIYSLVMSVHVPRTRESRSQAEAIAAQGYLPTTPISPTLAISYKTLELFRRLRLRKPSFSAEAFTKVICDYYAIPYRRRYRSALSDAFDIYLSIHRVIDKRVQAELGRGTPDWRVLNACPACCYELEDEPDLKIGRMYCFDGNNSLKRLAKVGERNVGDTRCFEDSDYFLSQDFVNQFADEVKSSRSQVAQEVEPQILPRGQDEEQFDDAEGDQTDAISSDPVTRGCMQNWKSAAAEDKKKMWGIFDETGIFASACRHGFILWIADMVRSGELAKYPLAMVAKVLQLLGPRSMGGYDIGCSFTHTIHDSSLSPEFRHLQARLCVNAFHGYTHNHACQTQNHPNVIEGMGLEDLETMERIFSKSNEVAPVTRYASRYRRRTFVDMFFGQWDADRYLSLGNFLYNNYRQALDILNNDAQVLDEAVRSLDIGDGDLDKWQKEETEYFSVLGQEPEWDVHAVAYVELLQEHYALETRHVDTTSLFLTSTPADYEFLPPPTRPSPSRIYNHELSQTRRLETQRRHIAERRQQVLRDVIAMEVHMGIVNRWQTTSTEYIETLQYVKLREYHRALDNLQRLVVQRLFELHNLNLAQTAYRVRTHMAKSLQTRCRAIRNAVNVYNALACQMDPPRPTLDWSKVTHYSFLEEFNLLRDTRNDIRDKPWTRPDIRAVMKQARRVARAREEIQRLDVEVRRVHTSIYDEVWAFDITLARLKDRNDPLYGAVNDFCHRRRRVNTWILARLKQIHALDKFTGNGQVGTRKGASVRTDNGRSLDLCTVHELEELDHEERAEDPQDNLGEDEDSSGDIGGIVDYVVNLPVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4U3</accession>
    <name>A0A401G4U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0100340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608075.1">
        <property type="nucleotide sequence ID" value="XM_027752274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4U3"/>
    <dbReference type="STRING" id="139825.A0A401G4U3"/>
    <dbReference type="GeneID" id="38774079"/>
    <dbReference type="InParanoid" id="A0A401G4U3"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="461" mass="50848" checksum="266EF6DE8111E1E2" modified="2019-05-08" version="1">MVHYLDSKGVKCTSLDPVHMGYAGESSPPIIVWIGVVPGSLSAEDDVEVATHCKSILSAHDIDDVHVEIRESEVIRSAGPKMYKPVLTSNATTRAREPFSTALGLPICAEVTPSIEGTGGFFISDPRNPSKIYLVMARHVVFHPDKGSNELYQHCDSSQCCRNILLFGDTAIEKHITAIESEIGGKHIIIKQLERRLEIAEQLDEEDAEVEWNQVLPQLEEAWKAIGALEKFLADDSRDWKKRENCVLGYIILSPPIGLDVREEGFMEDWAVIEIDDSKVDLTNFIRNVIDLSTTTPVDKLTAWMIPHPANPPSFEYPGSHLLELYGTISDEEMWKPSPKTLDHDNDPCIMVIKRGYASDLTVGCLNAIRSFTRVYFKGQPGQMSKEVAVLPHNYKSGAVSRPGNSGSAVIDGKGRFAGLLTGGARVTEESDCTYLTSINFLLKCMLEHGLKANLSPSLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Y0</accession>
    <name>A0A401G4Y0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0100740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608115.1">
        <property type="nucleotide sequence ID" value="XM_027752314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Y0"/>
    <dbReference type="FunCoup" id="A0A401G4Y0">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G4Y0"/>
    <dbReference type="GeneID" id="38774119"/>
    <dbReference type="InParanoid" id="A0A401G4Y0"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="8">
        <location>
            <begin position="404"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="677"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="729" mass="82085" checksum="65D2BAC81CDE7134" modified="2019-05-08" version="1">MQSLRSRRPSESSPKSQQRGNKLIRPSQRDLARKTTRVDDKIRKRMSMRYADISSPTSVDGVPPVPSLPIGTSLPMPGHGEEDGVIVSATTPAEDSRVVELRLLDNDEFDADAFLKLKLANSTEAELKTLQSSLQSQKQAVAVDLQHDVFKNYEEFVQVSKEVSVLENEMLEFKECLADWKSMPSLLHIEESASVADRRRNVRSSVADLRVLYANQMQTLHTQIEGSNKFVPTTAGRHVITELDNVLSLNPATYKVDHTTRFVVLDDAVLVARRRRRRNNAESDKLVAERCWPLNEMLVLDTKDTATMSNVFKIRHGKETHVYRTEAPGDKRHLLQQFRQVAEELSAKRRKEREGEHLRRKSLWGGDRNSVAFDAAPSPPPWMAEMMAQEMGSTAKEKAERDARWISDFSDDLTVAISLREWDQAVSLVEQGEANLPTMPSLAVKLNPLKASLTAALLQSLSMPTNRKTMVVSIISLLVRLKAGAAARNTFLAVRADLLRKRVRMIRFEGHIPLYISDLAIVVFTGIKHTADWFLASFRENEVASCFVEWARKQMEVYAEMFRKQVYSTDVDQETIEEAIKITHIQSRKLLEEYGIDFRFLLDRILIEKPKDTLPPPTFRSHPEKEPERTRVRASTPLRARSPAYPSVPPLRSPVPPVPPLPEIAPLSHTPRIVSPTPRAASAVSTRSATPTPRTRGSAAPPPRSRDRPGSATGHRPPPVAIPRREGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G609</accession>
    <name>A0A401G609_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0104820</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608515.1">
        <property type="nucleotide sequence ID" value="XM_027752714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G609"/>
    <dbReference type="FunCoup" id="A0A401G609">
        <property type="interactions" value="574"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G609"/>
    <dbReference type="GeneID" id="38774519"/>
    <dbReference type="InParanoid" id="A0A401G609"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE77602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="642" mass="72222" checksum="9F3B32D4793603CB" modified="2019-05-08" version="1">MAEPIPHTFPASKLGEYTVIKEIAEGTFGKVKMAVHTITGHEVAMKFISKQVINATKTKTRVQREVEYMRTLRHPHIIKLYEVISTPTDIIIVLEYAGGELFNYIVDHGRMPESQARRFFQQLISGIEYSHRLKIVHRDLKPENVLLDADLNVKIADFGLSNEIKDGDFLKTSCGSPNYAAPEVIRGGLYTGPEIDVWSCGVILYVMLCGRLPFEDEDVQTLFTKISQGVYHMPSYLSPEAKGLITGMLAVDPVKRITVPEIIQHPFFTTDLPRYLSPLPPRPGPVLGTLSSLVTPPKALDFEIIEGLGRIEEDVVDDLAVRMEGVDREDVWECLRRPDGPQGNAVKVAYMLLRDKRRLGRDLAEYAEQERDAQLAALDPRNLLSPTALSPGGTELEENPFESEFNGYDEDDDDGLDFSTPQNEAEISNFAVLNSSLPEQLPEQHHLASYASAKRQWPVREKKQHRTKWHFGIRSRSPPMEVMLEIYRTLRALGMEWKEKKDLGGLGGLKGDNRNSEKVKIDRAREFDGPGYVDLRAASSVYFVETRARVQDVVVLMNLQLYMVDSINYLVDFHHKKTYKASPDSSSGMFDMANPDTSLSETASESSRSVKDLSLREDEVVSPFVFMDVACRLILELAGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G686</accession>
    <name>A0A401G686_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0105560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608588.1">
        <property type="nucleotide sequence ID" value="XM_027752787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G686"/>
    <dbReference type="STRING" id="139825.A0A401G686"/>
    <dbReference type="GeneID" id="38774592"/>
    <dbReference type="InParanoid" id="A0A401G686"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="179"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="713"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1189"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1243" mass="136170" checksum="9893650065C24D84" modified="2019-05-08" version="1">MQITERRKLRRRWEEAAATVCSRPEMEEVAAATTVDGQQCALNSFSELAGAHRSSPSPRHSSHPPYKTPCLHRVCSLESSAIPATHNDTDYFLYLISLTMPPKYPARERTWGTRYDTLGSSPPPSPSKHVPPPIAIPHSPPTSVALSSDSRDMRDTTGEGPAVVSPNPVLKPDKVSHDASIFVGSLPSNVDHAELTRLLYEHLSEHTEVKNVKVVRDSKGGVCAFVQCEDTCVAARLIQALQALPPRPFLGRILRYEPARAFRTLLVSYRHSVKHRPIIGIDDSSDGGVQPEPAYAMRLYRPRNAKYLAILYNAEALNLDASSEESLSDNTVCQDSFTGEGLLLTSCKYDAETLRTLAQAFGTVGQFHPYDSDAEDKRYPHPHDGPRSPDMDPNVWEVKWDHRDDCVSALMTLRRIPFIAVSWAHHASLTSGPISDLRKSSSPFFNPRFSPSSMRTRTISQHHPGPVHDFQRLRITEEYASPKYESGAGAHLQASSSPHMTLSPASDSWAFAHSTPFLGTSSSLVPRVPELQGFRSVAGQRRSPKWSETDFPPLAEMEGAEGHGKDVRRWGDRDPQEASIDELEGGSAVSDSPSSSLSVNASTPVAEYVSQSPRVHERNLVQSQAPASYDPGRRQDINSVPPTPDFCVSPITPLTPRTGHNFPRTPTSAAGMEIMSYADPAQRSFNTPQNGKKSEGREDNPWFGDSGREVDRTTIFVGGLEMYGTNTWDETKLQSLFGRFGHIEDIQFVRPLNKRSAFAFIKFDNTESPARAVLEEHNRIHNGRQIRVQLRDTNPPQRSPWRYSRGRGRFPHAGQTRPHGGYAGGSYDGLSLDIGARSTGTPLDPMLLAAGQPERLSDNSFAVAEPTFLNHGGPFSDVRGADHSWLSRPGAHSQVGYAESAGAGIPSDTSSSTKVSSSQADAPGDLHSDTLDSLTPPPPASIGAGSSMDSIPAPMQQYTMTNMGYFPHQPWFHSYSPQYSYPVPFVHGYPGYPAPPAHGLPTFAGSDSANAHMGGQNPWVNMYKPMVPYAPYPTVAPGNDQIQVPQSNMQPPLRPTGFIQGEHGTLIPVYQPEALDQYMSNTQHTQSPPQGPTQGQPPLAWPHYPQVPMYPYAVQSQPMAPSSSQQTQLAQQRGWIPSPAPFIYPAPHQPQGHGLPVPYILPPGSSGSLSSSSSFRGSYTGATQNIHQFAHRSTPPPKPFNRREQHHNPGFNGNRAGHMRPSPHRATRFNDTATTAPYGIADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G695</accession>
    <name>A0A401G695_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0105600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608592.1">
        <property type="nucleotide sequence ID" value="XM_027752791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G695"/>
    <dbReference type="STRING" id="139825.A0A401G695"/>
    <dbReference type="GeneID" id="38774596"/>
    <dbReference type="InParanoid" id="A0A401G695"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF17">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="322" mass="36050" checksum="A6DB30AD226FBD64" modified="2019-05-08" version="1">MRRGNRLAFVDAMAAFVILAALLTLQARAFNPFLLQLTVPDTYPNISACVGLPSVYSCENSTAIQNTCCSPTPGGLVLQTQYWDTYTGLESEGQLLPIDSWTIHGLWPDNCDGSYEQYCDFSRQYDPYPSPSVLPNGTIVPPWTGPSVASFLIEFGRLDLLDYMNKYWINQGYPNWQFWAHEFSKHATCTSTFDVACYGPDYQPHQDVVDFYLAVIRAFQRYPTYTMLAAAGIYPSNTTTYSLASIQSALYSQTGGVPYLGCGGKNGTILEEVWYYSHVLGTEQFGNFKPLNTTDESSCNSTQGIWYYERTTGAEREVRLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6N2</accession>
    <name>A0A401G6N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0107140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608745.1">
        <property type="nucleotide sequence ID" value="XM_027752944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6N2"/>
    <dbReference type="STRING" id="139825.A0A401G6N2"/>
    <dbReference type="GeneID" id="38774749"/>
    <dbReference type="InParanoid" id="A0A401G6N2"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="160" mass="17631" checksum="BF0E7C8E8B5FE934" modified="2019-05-08" version="1">MTVRLRLAVHGARHNRIFHIVAIDMRHRRNAKPIETLGVFDPRLKPGETTKTIEWSASRIKYWLGVGALPSKTVTKLLTLVCAQARISWGTGDLTVEQGGVIPPHSQYHVNETYSLPEGVSTSAVTSEIKARLPKNTPASHEDTQAPSLSTRSSGDEQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G717</accession>
    <name>A0A401G717_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0108420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608873.1">
        <property type="nucleotide sequence ID" value="XM_027753072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G717"/>
    <dbReference type="STRING" id="139825.A0A401G717"/>
    <dbReference type="GeneID" id="38774877"/>
    <dbReference type="InParanoid" id="A0A401G717"/>
    <dbReference type="OrthoDB" id="1917726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="180" mass="20135" checksum="C5843E5E9EF44ACA" modified="2019-05-08" version="1">MNPPIVTNLTINPTVEQHEALRFNNEAQRLSREGDYRGAERLHLRAIALKEQGYGLNHFTTALSWNALGELYIEMGRLDESEDYLKKAVRVRNAAAAENDSHAFDAAVSRDNLARIYEMRGDMKQAKATRLSGGQTNLACSNFSVCYISLSQVFSTETGVNYSVYPSDLDSPAIIAMWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7F3</accession>
    <name>A0A401G7F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translin-associated protein X homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0109830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609014.1">
        <property type="nucleotide sequence ID" value="XM_027753213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7F3"/>
    <dbReference type="FunCoup" id="A0A401G7F3">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7F3"/>
    <dbReference type="GeneID" id="38775018"/>
    <dbReference type="InParanoid" id="A0A401G7F3"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="286" mass="32539" checksum="3BEC9C6ADA8DA6C1" modified="2019-05-08" version="1">MSGQSMPEILNSRDSILQVFDDFRDELDAHNDRRERLIKSSRDVTNLSKKVIFLLHRTMTEENFESNDHVLAVRAAGRAKEKLREIQNMFAAIREEVAGDRFWRYQKNVSPGLQEYIEALSFAHFLEHGTLISYDEVQQSLCDNNGIRYFPLPLEDYLLGLSDLTGELMRYAISAISRRGGRSKASEVCTFVRGCRANFEGLVPYYRELRKKQAVTSQSLEKIEDVAYAIAVRSSEYDLPPEILDDIVARTVSSAAYSGSQGDRRRKGGRGSRGHDDELDDGLDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8F6</accession>
    <name>A0A401G8F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0113170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609342.1">
        <property type="nucleotide sequence ID" value="XM_027753541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8F6"/>
    <dbReference type="STRING" id="139825.A0A401G8F6"/>
    <dbReference type="GeneID" id="38775346"/>
    <dbReference type="InParanoid" id="A0A401G8F6"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="101"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="390" mass="43852" checksum="4F65BC0E8B093D50" modified="2019-05-08" version="1">MPSRTAFHGVQSASELVDMSTVQTITQSAVGSAPAKLTVLPSAEDNKTEEREEYRYAHLLPVFPQDEHYRPLTPFDHGDPASRALSHPNPRAFLDNATSVVQLTPHLGEVVTGVNLATLDNEGRDQVALEVAKRGVVAFRDQQDFIDRGPDFYLEWGRYFGRLHIHPTSGHPVNYPELHLVYRDENSTFNFERSNSISSTGWHSDVSYELQPPGLTALFLFSQPSTGGDTSFTSQVAALKKLSPQFVAFLKTLKAVHSGFEQAEYSRSGRRGGVVRREPVKHVHPIVRRHPVTGEEALYVNRQFTRYIVGLKIEESNAILNLLYDHIDRSADVQARVKWEPYTVVLWDNRITAHTAIVDYLDTKQRRHGARITPQAERPIPALEGLDLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8V7</accession>
    <name>A0A401G8V7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0114900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609514.1">
        <property type="nucleotide sequence ID" value="XM_027753713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8V7"/>
    <dbReference type="FunCoup" id="A0A401G8V7">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8V7"/>
    <dbReference type="GeneID" id="38775518"/>
    <dbReference type="InParanoid" id="A0A401G8V7"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000105">
        <property type="entry name" value="WD repeat and FYVE domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46275:SF1">
        <property type="entry name" value="HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="11">
        <location>
            <begin position="32"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="10">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="737" mass="80426" checksum="F306E025C6705F27" modified="2019-05-08" version="1">MSSYLTSLLWGTSQVDDAVDKATSELLPSGAEDIALNLEICDQIRSKSVAPKDAMRALKRRLNHKNPNVQLLALGLTDTCIKNGGDLFLSEIASREFMDNLVSILKIPALNMDVKNKILRLIQNWAVAFEGKPSLSYVGEVYKTLQHEGFNFPPRDPAVTSSAMVDTQTAPEWIDSDVCLRCRTPFTFTNRKHHCRNCGQVFDQQCTSKVMALPHFGITQEVRVCDSCYTKLNKKSTKIHRTSQSVSGSRHHAAREFADADLQRAIQLSLQEVGAAGGYRPGYVPSPSPWQSSEPPLVDKGARPYAASTRSDADEEDDPDLKAAIEASLREANAPQPSAPLSVEVPAPEQSYGSYGIGAGYPQSYPPSASTPRPRAPAIPTYDLEPLESDAIMTFSQTVEQVQTQGGRDLSRYPAVTELFDKANSLRPKLAMSLSDTGRKEELLSEMHEKLSEAVKLYDKLLTEQVSRPAWRTPSVAPQTTGYQSGYNPRYQADGSYSHWTPEAQTQRQTAQAHAEPSYFSAYRDQSAIANGAYVTSPSADPYVHAYQPQQQSPPEVPRQFSQDQAQPQFAAMSPVTVPQYGAQAQLQTPAPPPIAVPYPPPVAAPVQPPASFQSPSLTSIPPPVQVQSPPVPFTQPQPPVPPMQSPILAPQPPPPTSTLTRHNTLSSPPAPAANAYVHRNNAPSYTSQQLQQLQQIAVPAAHLPHFPVAPTSSPQSFVAFSPPVEPERKEALLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G956</accession>
    <name>A0A401G956_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0116070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609629.1">
        <property type="nucleotide sequence ID" value="XM_027753828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G956"/>
    <dbReference type="GeneID" id="38775633"/>
    <dbReference type="InParanoid" id="A0A401G956"/>
    <dbReference type="OrthoDB" id="3268553at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="198" mass="22054" checksum="B338C78FDBDAE0CD" modified="2019-05-08" version="1">MADPPDDVSQFQSQEPPGPSGRGHRQPRSTTRLEGHLDSIAKSQARRQLYEARKLAQKSMDVPVQSLPQSYTGMLPISLSTLMATEASHEQAFMQQMWQPPDTSTVQEPHNMFMSSTMPEIAHRNLDNFNFESLTFDTLAQAHSYTYNPSIPSIHTAPNQLLLQHDASTAITLDQSFERQELALHVPGSSRPSPDGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G986</accession>
    <name>A0A401G986_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0116090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609631.1">
        <property type="nucleotide sequence ID" value="XM_027753830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G986"/>
    <dbReference type="GeneID" id="38775635"/>
    <dbReference type="InParanoid" id="A0A401G986"/>
    <dbReference type="OrthoDB" id="2753953at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="329" mass="36844" checksum="A3ED01AF7D072546" modified="2019-05-08" version="1">MATSIFKGSMRDPFPHSNFCLSLHLMANIPIDPVLLREEASVNPPSVLDLITEIQANNSTAPATPPSHASSPDPEEEDQAQEHLSKDQPHELARFAESPHLLQHTMYTYGLLLECRDYLQKLSRDSEYKIPDTLRATLMDYAHTYILSPTIESYRKASNPGNILAAMRHLNIAQIPPEQETGRCAVIHTVVAKGLTEWRNHVKTQISISIDAKSTIRNLAALAHACIKTCSVHPTVAMYIRLAYIRLIFVKFSGLKEDAFWNKVDSSMKEIREQYRTSGAIYDAYQAVYRNDKLTYGEPDNAMYPIALATSIPAFINDLNAASNSRGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA53</accession>
    <name>A0A401GA53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0202240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609940.1">
        <property type="nucleotide sequence ID" value="XM_027754139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA53"/>
    <dbReference type="GeneID" id="38775944"/>
    <dbReference type="InParanoid" id="A0A401GA53"/>
    <dbReference type="OrthoDB" id="2757769at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11093" checksum="DD08F92ECC08F82B" modified="2019-05-08" version="1">MLQNGNDAILITDEVGIGKTAQVLGVICMVANSGLENRPVPTFAKCIHSLHACHSSATGGGPLESTPHIIISTTTLQQIWLSEAHMWCTGFEFFEYTGRYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBD6</accession>
    <name>A0A401GBD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0206900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610403.1">
        <property type="nucleotide sequence ID" value="XM_027754602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBD6"/>
    <dbReference type="GeneID" id="38776407"/>
    <dbReference type="InParanoid" id="A0A401GBD6"/>
    <dbReference type="OrthoDB" id="5599163at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="23320" checksum="1B635AA0ACF53ECC" modified="2019-05-08" version="1">MKDAAPSPVYYLHIVEEEAEEENPVPEPLYYSMEPEDDEDYLFAGIEKEVYGAYKCVDRKVKPVPGVFPEGARVHCAFPEDPLASLPLLTPHLPDFTPGMQLTQEQMEEMNIKPDGFLRPEEEKLFKHILRLNEAALAFEDTDRGMFREDYFSPYIIPIVLHKLWEFSNIPIPPGIKEKVIKLLKEKMAARVYEASQSLYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBF4</accession>
    <name>A0A401GBF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0206950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610408.1">
        <property type="nucleotide sequence ID" value="XM_027754607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBF4"/>
    <dbReference type="STRING" id="139825.A0A401GBF4"/>
    <dbReference type="GeneID" id="38776412"/>
    <dbReference type="InParanoid" id="A0A401GBF4"/>
    <dbReference type="OrthoDB" id="3070852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11219" checksum="56A6B0E8D7B55DC8" modified="2019-05-08" version="1">MSNDSASEPPSSVVSFSSYADLHTSASSSTSCSSVDFGYNLFTSYGLLLGSGNQVWHPPMLPPDQSPCFIHPPMLLPDESSGMFLHPPMLHQDDTDTIRAQLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC91</accession>
    <name>A0A401GC91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0210070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610719.1">
        <property type="nucleotide sequence ID" value="XM_027754918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC91"/>
    <dbReference type="FunCoup" id="A0A401GC91">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC91"/>
    <dbReference type="GeneID" id="38776723"/>
    <dbReference type="InParanoid" id="A0A401GC91"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000609">
        <property type="entry name" value="U2 snRNP component IST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="326" mass="37830" checksum="BBBE202CA3724654" modified="2019-05-08" version="1">MNVVREINKINELELNLNTTGSWHDDYKDSAYIFVGGLHSDLTEGDVIAIFSQYGEVMDVNLPRDKDTGKTKGFGFLMYEDQRSTVLAVDNLNGATVLERTLRVDHVKNYRQPKVKGEDGEMVEREEQSLNARPEAIMDDDAASESPESSQPPIDPEDPMYEYLVAKRKEEKALKKAEKSKSKSKSKSKGKHKDETPEERHARKERKRMRKNLGKSEGMKGVEKLLNSLQGRDRAERDTRRYSSPPPDRSRSRSRTPRRERVIEDRRYSPERRSRTRYSAREEGSHRRLRSRSRSPTRFHGDERASGHDDMDDDSRPPMRKRMGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCK4</accession>
    <name>A0A401GCK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable prefoldin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0211060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610817.1">
        <property type="nucleotide sequence ID" value="XM_027755016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCK4"/>
    <dbReference type="FunCoup" id="A0A401GCK4">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCK4"/>
    <dbReference type="GeneID" id="38776821"/>
    <dbReference type="InParanoid" id="A0A401GCK4"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="129" mass="14443" checksum="62378EC5CEF83520" modified="2019-05-08" version="1">MSSKAKAKQVQPTVTPLSTQEIQQNYNRLQNELQTLAGKIGELEQEAEEHSLVLTTLDEALAEEPDRKCFRLVGGVLVERTVKDVVPALQTNRGGILKVISTLAEQYKTRDEEFETFKRDYNIRPAAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCU9</accession>
    <name>A0A401GCU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0211890</name>
        <name evidence="3" type="ORF">SCP_0211950</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610900.1">
        <property type="nucleotide sequence ID" value="XM_027755099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCU9"/>
    <dbReference type="STRING" id="139825.A0A401GCU9"/>
    <dbReference type="GeneID" id="38776904"/>
    <dbReference type="InParanoid" id="A0A401GCU9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF440">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18788" checksum="0FFB4310B08BE6ED" modified="2019-05-08" version="1">MDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHYVRTRRVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCW2</accession>
    <name>A0A401GCW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0212280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610939.1">
        <property type="nucleotide sequence ID" value="XM_027755138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCW2"/>
    <dbReference type="STRING" id="139825.A0A401GCW2"/>
    <dbReference type="GeneID" id="38776943"/>
    <dbReference type="InParanoid" id="A0A401GCW2"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="25554" checksum="C14B8458057EE2E1" modified="2019-05-08" version="1">MPSTTLEFDAILFDMDGTLVDSTAGVVGAWSLFAESYPGINVHEILSSSHGVRTVDNLRIHCGVEDPEELQREAVRFEEAIVSTSSLNGRRGIVALPGAHEIIDDLLSVAKFPKPRWAICTSATRSYASAALNLAGFPLPDVLVAAEDVTKGKPEPDPYLLGAKRCGVPPERCLVIEDAPSGVRSGNAAGCKTLALLTTHSRKQVEDSQPDFIIKDLSSVNMRRTENGIEVEINIASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD22</accession>
    <name>A0A401GD22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0212870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610997.1">
        <property type="nucleotide sequence ID" value="XM_027755196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD22"/>
    <dbReference type="FunCoup" id="A0A401GD22">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GD22"/>
    <dbReference type="GeneID" id="38777001"/>
    <dbReference type="InParanoid" id="A0A401GD22"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="10"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="292" mass="32894" checksum="52FC040C3C1B4A3C" modified="2019-05-08" version="1">MSKAQLEHEISITKLTYSHAPDLSPSLSDITLDLPKGSRTILVGANGAGKSTLLQILAGKRLISKDDTRVEVKGRDVFRHSPPGVTFLGTEWAMNPVVRGDIVVSNFLNSVGGYRHKARRDRLLDILDVDLDWHMHAISDGERRRVQLCMGLMSDWDVLLLDEVTVDLDVLVRDDLLKFLKADSESRGATILYATHIFDGLNDFPTHVAHMHLGTFLSQPTPWPLTEATTLNDVSMDLGPSPSLYTVALQWLKEDRGLRRRLEKDGRKMRGAKHDHVPSDSETFYRKYDYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD70</accession>
    <name>A0A401GD70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0212840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610994.1">
        <property type="nucleotide sequence ID" value="XM_027755193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD70"/>
    <dbReference type="STRING" id="139825.A0A401GD70"/>
    <dbReference type="GeneID" id="38776998"/>
    <dbReference type="InParanoid" id="A0A401GD70"/>
    <dbReference type="OrthoDB" id="2740399at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF74">
        <property type="entry name" value="POGO TRANSPOSABLE ELEMENT WITH KRAB DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="334" mass="37454" checksum="AB1671AA60F0EF03" modified="2019-05-08" version="1">MPRAAVLHKKGLTIQNREAKIQQAVDGIKNGTYATPKIAACALGIGSQYTTIWRRLNNKTRPQCEAHQAKQLLNHAQERTLVAWTKWLGFTGQPVTRETISPKVKALCGKDPNPKWIERFLMRNPDCTMGRPAGLDPKRASAFNYTTVNHHFEELQKTIDLYDIPPCNMFNFDEIGIQLGGGRKGSREQFFFASEDQSHYKLKSDDLELVTVLETVCADGSSTVKPGFVFAGVKMCEEWISEEDGIFLATTDNGWTDDHVSQEWFQRAFIPAAKAHSDSSKPVLLMFDGHGSHVTYEMITIAEKENIVLYCLPSHTTHRLQPCDVGAFGPLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDE0</accession>
    <name>A0A401GDE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peroxisomal coenzyme A diphosphatase 1, peroxisomal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0214090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611112.1">
        <property type="nucleotide sequence ID" value="XM_027755311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDE0"/>
    <dbReference type="STRING" id="139825.A0A401GDE0"/>
    <dbReference type="GeneID" id="38777116"/>
    <dbReference type="InParanoid" id="A0A401GDE0"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034654">
        <property type="term" value="P:nucleobase-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090407">
        <property type="term" value="P:organophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000036">
        <property type="entry name" value="Nudix hydrolase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="55"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="303" mass="34100" checksum="7216C1B996EB2864" modified="2019-05-08" version="1">MFKLKSRRSNLLKFHRPKLQLNEAPIPVLKLESKQCIQNLLNYQPPKIRLQIPRSRCAAVLVALFVGRTGDLYVLLSRRASTLRTYAGDTSLPGGKWDAQDHSIEWTARREAFEEIGLPMDRQKVPLLCVVEPFLAGNQLVVIPVVVLILDNTLRPILNAPEVASLFSHPLISLLHSEPPFSTEPEMLEMKYHTYVDIAAHEGHVRMHRFLTGREAGGTKPIFGLTASILIRVAAIGYGREPDFEVFAPDQPSWEERLAHVLRHHLVFREAAQQEGIDPDKTAGSKTDDAHPGARRGRVRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDQ7</accession>
    <name>A0A401GDQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0300150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611213.1">
        <property type="nucleotide sequence ID" value="XM_027755412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDQ7"/>
    <dbReference type="STRING" id="139825.A0A401GDQ7"/>
    <dbReference type="GeneID" id="38777217"/>
    <dbReference type="InParanoid" id="A0A401GDQ7"/>
    <dbReference type="OrthoDB" id="3263571at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="234" mass="27104" checksum="8091B091514B364D" modified="2019-05-08" version="1">MDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSRVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYRSWKEFIMSVNKAFGDENIEETARTLLHNIKQGTRTANDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQKIYGMESMPKTLDKWYEYASQFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSTSAKDPNAMDVDCINISRLSPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEN2</accession>
    <name>A0A401GEN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0303470</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611543.1">
        <property type="nucleotide sequence ID" value="XM_027755742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEN2"/>
    <dbReference type="FunCoup" id="A0A401GEN2">
        <property type="interactions" value="1169"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEN2"/>
    <dbReference type="GeneID" id="38777547"/>
    <dbReference type="InParanoid" id="A0A401GEN2"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="14"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="461"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="859"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE80630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1214" mass="133519" checksum="D25B7068124592E6" modified="2019-05-08" version="1">MLHLYNLTLQPPTAITHAIAGNFSGSRQQEIIVSRGTRLELLRPDVQSGKVSTVVASDVFGSIRSLAAFRLTGGTKDYAIVGSDSGRIIILEYDPRSSSFVKVHQETYGKSGARRIVPGQYLAVDPKGRSVMISAMEKAKLVYILNRDAAANLTISSPLEAHKNTSIIHDIVGLDVGFDNPMFAALEVDYSESDQDPTGEAFNNAEKMLTYYELDLGLNHVVRKWTEPTDPRANLLVQVPGGQLASSDRYDGPSGVLVCCEDHIIYRHMDAPQHRVPIPRRQHPLSDTDRGLIIIAAVMHKMKGAFFFLLQSEEGDLYKVTIEHHDQDVRSLKIKYFDTVPIASSLCILKSGFLFVASEFGNHYLYQFQKLGDDDNEPEFSSTSYTSFGMADPSSSLPHAFFRPRALDNLILVDEIDSLCPILDSKVMNLLPNSDTPQIFAACGRGPRSTFRMLRHGLEVEEVVSSDLPGIPNAVWTTKVKEDDPYDSYIILSFVNGTLVLCIGETIEEVQDTGFLSSAPTLAVQQIGADALLQVHPHGIRHVLADRRVNEWRVPPGKTIVSATTNKRQVVVALSSAELVYFELDLDGQLNEYQDRKAMGSTVLALSVAEVPEGRQRTPYLAVGCEDQTVRIVSLDPESTLETISLQALTAPPSAICIADMLDAGINKTQPTTFVNIGLQNGVLLRTVLDPVNGQLTDTRTRFLGTRPIRLVRVVIHNNPGILALSSRSWLNYTYQNLMHFTPLIFDNLDYAWSFSAELCPEGLIGISGSVLRIFQIPKLGTKLKQDAIPLSYTPRKFISHPTNGLFYLIEGDHRVMGEAAAAKKLNELRQQGRMVDDEVVELPPALFGRPKAPAGTWASCIRIIDPVSAQTVNVIQLDNNESAFSIAVVPFSVRGGELHLVVGTAQDTFLAPRSCTSGFLRTYRFVEGGRNLELLHKTETNDVPLAVLGFQGRLVAGVGKSLRLYDMGKKKLLRKVENKTFASAIVSLHTQGSRILVGDMEESVSYAVYKPPENRLLVFADDTQARWTTAMTMVDYNTVVGGDRFGNVFVNRLDPKISDQVDDDPTGAGILHEKGVLAGAPHKTKMLAHFHVGDLVTSIHKVSLVAGGREVLLYTGLHGTIGILVPFVSKEDVDFISTLEQHMRTEQGSLVGRDHLAWRGYYVPVKAVVDGDLCETFARLPANKQSAIAGELDRTVGEVLKKLEQLRVTASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEQ4</accession>
    <name>A0A401GEQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0303360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611534.1">
        <property type="nucleotide sequence ID" value="XM_027755733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEQ4"/>
    <dbReference type="STRING" id="139825.A0A401GEQ4"/>
    <dbReference type="GeneID" id="38777538"/>
    <dbReference type="InParanoid" id="A0A401GEQ4"/>
    <dbReference type="OrthoDB" id="2757691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="402" mass="43960" checksum="83C1DA9C65929E45" modified="2019-05-08" version="1">MMPSQGPPPSVGGKDLSSFVPDGSGSGGSTAGLPNPAQLALFQENWERQARNAARAVRRQGGEDSVSDDEELGMLDGSDGASPGQLDSQEPSAMPAGAPSRPRTPEDDTDNLQLLRDVMKMTPNSRGIALKLWNAGVDKRSGTGPRAEATAGSGGKGSENALITIDSEIKTDLFAGRVIETPQELPALLRNGFHLPLSMCTSEVMTKMHKHPEQVQYRKMHDGKGIKRALIDIAQWPDEQTLKPEEWRDAWRNYFEILPAICDDEIVKRFSEHYMWLSGQSDFNRIFPVILAFDIDGRRGYFLTKKTFVVDSKSYNDHFLKVRLEHIENGTRGTLPIPAAPIAGSSQTPYRTPSHSPDSRRPRRDGAADSTAKPFRDSRASASTSMLCLICGESGHRASQCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GER6</accession>
    <name>A0A401GER6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0303080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611506.1">
        <property type="nucleotide sequence ID" value="XM_027755705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GER6"/>
    <dbReference type="GeneID" id="38777510"/>
    <dbReference type="InParanoid" id="A0A401GER6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="581" mass="60855" checksum="8FB91F344409C970" modified="2019-05-08" version="1">MLILSLIFTGAIALVGLFGGVPTGVSDLWFNVHVLDELLYPVVYLVDAFFDKLETMDSGTFLPFNMLRLPPSLPAVPDTLLEIHIMASTPTESYPSISANLITTYTAAANQHFFVTICIAGLSLSVATTLVSMLVTIIRDRLQHGQEGLKHDSKKVAHTEHNSASILSQSIIPLMPSEEPAPRRISSSNSLELFGFPSSSFDLPLPAAAACANTVLISVESVLAGLGSDKSEITAMAFSADSSATRGNASDAVGTSSPTTADIPLAAAVEEQPVPSFAALLPPIVDELLVPVVDEQSVSTAQAMPPASAELTHAVEASVGETDSSSVGLSPSSLPDLVSSPRPSNQSETPMTPSGVRRSRRAGARVHVRQSRAIEKCFSELQELPFQMEAEPSALPSPVVIPPSPVSIALSPLQALIALIPLAVRSIPSPSVRAVIEPVGVSGPFSPPRLPEPSSRSPLLSMSRLSGLRASLWAPSPEDGPTPSPAPNATVIGPDFSPGDHRHPLASSKADRSSWWTTSASPAPRVSRWEGSSDSSSSSRTRYPGLAGLKVGGYMGRLAELWSTRAEDTCTSASSQTAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEZ9</accession>
    <name>A0A401GEZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0304760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611670.1">
        <property type="nucleotide sequence ID" value="XM_027755869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEZ9"/>
    <dbReference type="STRING" id="139825.A0A401GEZ9"/>
    <dbReference type="GeneID" id="38777674"/>
    <dbReference type="InParanoid" id="A0A401GEZ9"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="419" mass="48032" checksum="67F0B6D7F08FD2C8" modified="2019-05-08" version="1">MTFTPALQDLFALGVIAAVYAFYYLRSRKGPQGSDSTASQAPQRVLQQDGKEYVKSVPILACEVLPDPDPLVDFDLATASTRDYIYANKTMRYPYFQTMSHQPMHINHWIEIDNEYEWYLGEKARIVEEQGKVALDSLPENDDACGELLELVVDYLPKRFPTLFERIPSGLGIWNKVTNERFPDVSALRGVEALRVVSRLVQDDFLMARERPDGRIYLVGGLLAFPGNYLLSEKMDQPVHVLHDPVPHFNSKLLLSVERTLVRFTPDKPFERSSWMIVDDRSLFWHNIASVPVPDTLHPKDLFLRVDHQTFRKLRRTGGIMFGVHPVLKRIGTLADSPLVPAMLAKLHTESDKALLDYKLVEKYNPILLPYLQEVTEQQIARGLIREEDLEDVSKFREHVGGEFPMWHVKPTREAQAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF70</accession>
    <name>A0A401GF70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glucan endo-1,3-alpha-glucosidase agn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0305640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611757.1">
        <property type="nucleotide sequence ID" value="XM_027755956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF70"/>
    <dbReference type="STRING" id="139825.A0A401GF70"/>
    <dbReference type="GeneID" id="38777761"/>
    <dbReference type="InParanoid" id="A0A401GF70"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="427" mass="49202" checksum="355220CF606392A2" modified="2019-05-08" version="1">MCARKLVVAHFMVGNAYPYTVEDWLDDIRLASSHGIDGFALNFGRDEWEKSRVADCYHAALQSGVPFKLFPSFDMTLIPANCSDDVQSFCDYVTRYRGHPNQLLHHGKVFISTFAGESNLFGHTDLNHAWKFVKSTLEEIAPVHFVPSFFIDPARYPHITAMDGYFNWNGSWPLHLHPGSPREEVKYPRLDTDRHHIHHLGGRTFMAAVSPWFFTHYGPDSWNKNWIRRGDDWLYVRRWEQLIAMRDEIDIVQIISWNDYGESHYIGPIKGAQPNSQAWVDGFPHEPWLHLTRYYADAFKNGHYSAIEKDQIYMWSRPHLKDADATEDTLPRPENWHLTDDEFWVVIFSTAPGLVVLTSTDEQVPQTVEVAGGVTKLSSKMVPGGSMKAQLFRSRVLAAECTPERDGFRFQTQPRVFNFNAYVTMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFG9</accession>
    <name>A0A401GFG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0306590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611850.1">
        <property type="nucleotide sequence ID" value="XM_027756049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFG9"/>
    <dbReference type="STRING" id="139825.A0A401GFG9"/>
    <dbReference type="GeneID" id="38777854"/>
    <dbReference type="InParanoid" id="A0A401GFG9"/>
    <dbReference type="OrthoDB" id="6082470at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="103" mass="11575" checksum="03E6F36A47DA2624" modified="2019-05-08" version="1">MRFPSSVAWHREIVYNCVWSLLVEIDEHNNRAAVDPQPFPIETVVMTGLATGIGCVSANQCAKHTALAFAHYHDAKTNPEKWSAMTWGDIAEHPLNIRLPTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG67</accession>
    <name>A0A401GG67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0309110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612097.1">
        <property type="nucleotide sequence ID" value="XM_027756296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG67"/>
    <dbReference type="STRING" id="139825.A0A401GG67"/>
    <dbReference type="GeneID" id="38778101"/>
    <dbReference type="InParanoid" id="A0A401GG67"/>
    <dbReference type="OrthoDB" id="3013446at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1028" mass="112919" checksum="5BBCE5894CA995FD" modified="2019-05-08" version="1">MATALQLPPPDTGLAFNEVVTTGLAAHDYPNALNFADFDLKDNRYPSLGTSCRVTQYVNSPGRYSNSAVDPVALSPRHRSWIDRPVPNSSAGVWVPEKLMEQQQQRQAEQSAPLQGPLPATNQQPQPPMPRPEDTLSRPMQGSPSRLAERFSRDEELQRIPSKGSDSPQEMGQRTSSRRPSQDQYGSFVPSSPRHPSLPVAGFGAGPSSSPIVPVSAGPSYNPANMQIPISPKPRAYAQHPTYITPTPGANVYAPPQVPKEEVCVECAMRDQDMADVDVASPGAWERDSDVLYDELIRREQEDEAAGTPPSEHPNRPRARGGRLTEESLHLWLSLNPKEPSSRQQTLDQYVRSQRTLLEAEVLAHARAMRESRQLDDKVRDACSQLRRSAYDLNVNPKHAEDASVKASRSSSMPGGAVIAHTHGHSRDVTLLENGMIVEHVDVRKEEKEERERRRKEERLERSRVRKSSRGSAIDVTSVYSMPIPNQLPKTDSGFFSGARASESRYSQSFSPRPSSVLTTGNERPLTSLRATSQASFSDIQSIGSTSSPRRSRFFGFKNLTSGFRSQDSLAPSGSMVDMHIALSREQHFFEAHPELEQEFGSNAPTVRLADAPQQPGVFSEVIDAPSSAVPKKKIGLKKIWKIVTGSKNSGRTISRAKSRSLDRAEDDLPLAPPPPLSYLVDREQRLSSRRHVSTPSLPSSASPNAMSPYAPSPPTAPSSLVPSPSSSRQPITEKENLSDGRKDSGNYETDHDHIPSADVNSPEQDPRGRTTHSSSKTLSSYTGPITPVTPQSNRPQSVAIRRDKSLPPLPGESSIEFPNHPMPDARPQTMYTYDPLMSSYGKATSPQLLPPQAPFRSVDTRRQSFGGMASQPHPAVRTLPAKAAYMRGPLNVPPFLAEERYGEFGVSHLSLNQWNNGKGHLRPVQPQAKPKQRRSRFGLASLFGRKSQDAESKDLAGVDASLQPIITHRTSASGEHSAGYGGPGSAHSSTAMRMSVTSRKNIAELVDQDNEFVAYRYPSTDQRFDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG71</accession>
    <name>A0A401GG71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0308280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612016.1">
        <property type="nucleotide sequence ID" value="XM_027756215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG71"/>
    <dbReference type="GeneID" id="38778020"/>
    <dbReference type="InParanoid" id="A0A401GG71"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="91" mass="10356" checksum="066071033A965E1C" modified="2019-05-08" version="1">MSVNNSSDELTRLRVVVDATSLHQLTNTSVTWWRQMSARTWCLFSASFLVNVLPQPPLHTNGFSPVCVSRCRFRSCCLLKDNAHMSQEKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG98</accession>
    <name>A0A401GG98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pali-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0309410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612127.1">
        <property type="nucleotide sequence ID" value="XM_027756326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG98"/>
    <dbReference type="STRING" id="139825.A0A401GG98"/>
    <dbReference type="GeneID" id="38778131"/>
    <dbReference type="InParanoid" id="A0A401GG98"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019169150" evidence="6">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="20064" checksum="702633CBC134B401" modified="2019-05-08" version="1">MAAGAAIPGLFFTFAAMVLLIFASVSPPTWNPISFLNTNVGGVSTHFGVFGYTGSTTHVGWHFPSGIGDNTINDTTFHNLTYILVLIPVAAGLSGLSWLFGLCGAAYHRAGTVFMTLLSAVAFLVTLIAWVVEMVLFGVARNHVRDAGNYAQYGNANWLVLGALLALLLGFFASLCGSFGRYGSRRSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGB0</accession>
    <name>A0A401GGB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0309510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612137.1">
        <property type="nucleotide sequence ID" value="XM_027756336.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGB0"/>
    <dbReference type="GeneID" id="38778141"/>
    <dbReference type="InParanoid" id="A0A401GGB0"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039767">
        <property type="entry name" value="RALBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783">
        <property type="entry name" value="RALA BINDING PROTEIN 1 RALBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12783:SF5">
        <property type="entry name" value="RALA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="670"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="921"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1332" mass="140926" checksum="04BF81B82C9DB196" modified="2019-05-08" version="1">MYSRNKDTHARNVAVSQSTSSLSSSLSSSVESSTLFPAATPSNSSQSDIATSDRSVASLTTSKSRFFPLSIAPRSTTTMGQATSQVPQSVPASPTSASSAGNKFKRAFAGRRKKSQDITAFLADTEGPTRSGKEREPTDTSSVVSPPSVSDHSHRTVDSTSRHCKDLSVNIAPTKFSVFGKKVGQSPKSPKFSGSPPLASPPPPLPPKSVTLPAQNKAALASVSGDSHSTEHPLPPPPSPPKLFLQVTAERLKTALPATPSDGASKTEGPVVAKEKPAQEREGDSHKEDWRKSDSTMASHYTVRPGALAGNRSPRPVSLAESSHSGNTIVPVNKRFSAIITDAEFSMVEESEGSEHDEDILSHLSISERASPNGSMKARNRRSVSLNFGPISPTKSKPSVAEPSSRPLPNTPTHAPGRFASDPLPAHDAPTLTRAAATGIIAPTNSSSTTHTTTGFHIRSRLAAWTSASLAPSYPAQNESAPPSSFAQPRRPSATPSGQPFFRQTAVSMTGSLAPTAGIAKGLGKRAVEKVGRVWGGFSSGASTASGYSSSSSMGRSDTSLRPTPSLESNATQPSMSEKRKFRRRTGHAFSGAASISSTSSSISDADHFVPTSPSLGTRLRGSRLSSAGAPVAGGLVFRRDLKECVRETAIDAVRLSMLKDSDDVDSGIRPLEERWLPALAVRCAQHLLKWGVQEEGLFRVSGRSSHVAKLRSEFDVGGDYDMAICDPGDLDPHAVASIFKTYLRELPDSILTSALIPYFESAMVAEEQARTSIDSETSRVAGKVGPSLSSGPQGGLPALRKPPSLSTLAMPSFATKRNVSESLLNALTWLIAQLPRENRDLLYTVVQLIKATADHSKETKMPMGNLLLVFCPSLNMNPNLLRVLCEADCIWNGVPKPPVENVISKVPEESENEEVEGTPSINASVISSSSMTSGEVSSSGEPTTEDEAWTLDTPEGSFKAPADDILEVAVSEPDQKSEQPITRISAMSVMKDDDASYVSAQEILSAVPTRSPSPAVSGPHIPPLLTSSDSSSSSSTNYEDPVSPQLPSSEDAAVTVIPSSEDSASAAMNSSRSSDPLRPFVPFPSSGRESPARTMTHRKSFTLLSFPQIRTASTESSAPSASSSTWPARTKRPSLHLLFSKSVSRLVSPTSGPPLTAASVPTLALTTEYGETSRAAFPSSSLSPPVLDTSISSSPIYLEFDDLVSHVRSNKEEDVSKPSGEAAESQQQLLHTHVRADSYAPSVYTTPMGMTPRETPIADFYQNRSKSLISFHGEEHVSPVTRARSESAVSQIIATPSIQIGVEAPEDWAQSVLLAARGESSAGKGSEEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGL8</accession>
    <name>A0A401GGL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612231.1">
        <property type="nucleotide sequence ID" value="XM_027756430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGL8"/>
    <dbReference type="STRING" id="139825.A0A401GGL8"/>
    <dbReference type="GeneID" id="38778235"/>
    <dbReference type="InParanoid" id="A0A401GGL8"/>
    <dbReference type="OrthoDB" id="3238622at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="291" mass="33201" checksum="505C61178E1F7909" modified="2019-05-08" version="1">MQADAEEEDKPAVSSVLHPLFSSDEGDVFLGSKDGTQFRVHSYTLKTTSGWFRTMFSLPQKQDSNSLEVIYVDEDTETLEAILRMICGLPIPRLDSYEAIEPILHAAEKYDMIGPMSIVRAVVMTPPLLADPLRLYAITCRYGWLDEAKLASQYTLILDLHAPEHRHTLLKLGTLALLNLMELHRNRREALRRRLNEPPFVNDNGNTLCSHCGSVVDYHTWRELKYVIILEMDVRPLGDTVCNEGLLDWPAARACWDARCVSCDRVLYDKKETLRVIRECIDQLPTTVEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH95</accession>
    <name>A0A401GH95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0312950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612479.1">
        <property type="nucleotide sequence ID" value="XM_027756678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH95"/>
    <dbReference type="GeneID" id="38778483"/>
    <dbReference type="InParanoid" id="A0A401GH95"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="68"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="273" mass="29751" checksum="351C046881088244" modified="2019-05-08" version="1">MAAELPKFNPAPAFKFSQSPNPSYKFGEGLDPNVSELAKGWKEDEKKGWKSWTLEETHGKDVYTLLTSSVIPRPIAFVSTLGADGTPNLAPMSYFSLIAHDPPMIGLSFALFMGIPKNTRDNILATKEFTVSLISEPFLEAANACSIDAPPEVNEWLVSGLTPVPSNLVKPAWVKESAISLECELFQVHHLASLHNSMEITTTFVMGSIKRVHVRNAVLGADGVNVDPAKLRAVSRLGGFTYARVGEGIDLGIPMWAQDQTAVTEVVERKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIK5</accession>
    <name>A0A401GIK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0403830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612920.1">
        <property type="nucleotide sequence ID" value="XM_027757119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIK5"/>
    <dbReference type="GeneID" id="38778924"/>
    <dbReference type="InParanoid" id="A0A401GIK5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8577" checksum="28243F6AE842092A" modified="2019-05-08" version="1">MRFESKSYSTKGSNPGHQRFCETCQPTCPSLFASSCPHHHSYLYAGGPRAREKSIAQLCQNTGSKLHQKCAHVTYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJD5</accession>
    <name>A0A401GJD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0406580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613187.1">
        <property type="nucleotide sequence ID" value="XM_027757386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJD5"/>
    <dbReference type="GeneID" id="38779191"/>
    <dbReference type="InParanoid" id="A0A401GJD5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="66" mass="7541" checksum="DAAFED196144A647" modified="2019-05-08" version="1">MPKRRGSQSKNTQRKKQHIDSQDPGAAPSAPDRRLRPKDVEPPKRDRRAHVEDADDDDDVEPPKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJW3</accession>
    <name>A0A401GJW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Allergen Asp f 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0408270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613356.1">
        <property type="nucleotide sequence ID" value="XM_027757555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJW3"/>
    <dbReference type="STRING" id="139825.A0A401GJW3"/>
    <dbReference type="GeneID" id="38779360"/>
    <dbReference type="InParanoid" id="A0A401GJW3"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019498142" evidence="3">
        <location>
            <begin position="21"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="298" mass="30812" checksum="6F24ED11ADEBC3EC" modified="2019-05-08" version="1">MRLSTLLGALLSITLPFVAANPRNAHGNSLGRRHDEVARRARGDLARRQATVNGPYANSRFTFYAVGLGSCGITNVESDYIVALNSAQYGGGYPGPNCFLSITIQVGSITATATITDECPGCPSGGLDMSQGLFEHFADTSVGVLTGTWWVNGAGSNPTTSSPPAYTPTTPAWTPEPSPTTSDTPVWTPSTTWSPPPPPSSTTPVWTPPSSSYTPWSSSVSTPSSSSVWTPSSSTTPSSSSAPSSSWTPSSSEAWIASSSSVAPAVETPTSPDTLEAVNQVVVGMAALMVAGAQQHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK44</accession>
    <name>A0A401GK44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0409250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613454.1">
        <property type="nucleotide sequence ID" value="XM_027757653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK44"/>
    <dbReference type="GeneID" id="38779458"/>
    <dbReference type="InParanoid" id="A0A401GK44"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="137" mass="15614" checksum="8097F350D562E4EA" modified="2019-05-08" version="1">MAAAWDSRGRCVNSSGEAQRLVSGTRRNTEEHLTIERGLAQRKIWIWRAHVKVGEQAKTASTSPRERRAHEYIPVFEAEQQNPIYFRGLVQHLSCILSTPTENTLTYLRQMLSPEGGERRGHDTTITHCSRIIDSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKM1</accession>
    <name>A0A401GKM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0411030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613631.1">
        <property type="nucleotide sequence ID" value="XM_027757830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKM1"/>
    <dbReference type="GeneID" id="38779635"/>
    <dbReference type="InParanoid" id="A0A401GKM1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="67" mass="7288" checksum="636D1076C4B625A3" modified="2019-05-08" version="1">MAELVPGPDPSDEERAKFENFECVKRDGFETDMYPGLCTVFQSVINAVPQSGLSAKDTGEYPDVTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKM6</accession>
    <name>A0A401GKM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0411010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613629.1">
        <property type="nucleotide sequence ID" value="XM_027757828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKM6"/>
    <dbReference type="GeneID" id="38779633"/>
    <dbReference type="InParanoid" id="A0A401GKM6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="70" mass="7401" checksum="804F24B5479AC190" modified="2019-05-08" version="1">MLSPSPRGIDKDTALDVARGGREMRADDTHSSPPANLVVKSGSPPVPPLARRRSSALRPQAQLPSAHDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLH6</accession>
    <name>A0A401GLH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613950.1">
        <property type="nucleotide sequence ID" value="XM_027758149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLH6"/>
    <dbReference type="GeneID" id="38779954"/>
    <dbReference type="InParanoid" id="A0A401GLH6"/>
    <dbReference type="OrthoDB" id="2754287at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="100" mass="11102" checksum="13914C64A8315ACD" modified="2019-05-08" version="1">MPSSKSSRMLQTTSPLPRASSSTALDDSKNARTRQWLTRPLDRADLATGLHAVSERLQGADLAEDEWIVSLLSELAAHLRGRDEEQSRYLSEAVVRLQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLL5</accession>
    <name>A0A401GLL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0501120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613979.1">
        <property type="nucleotide sequence ID" value="XM_027758178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLL5"/>
    <dbReference type="GeneID" id="38779983"/>
    <dbReference type="InParanoid" id="A0A401GLL5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="70" mass="8118" checksum="8425BE2FA9096BC0" modified="2019-05-08" version="1">MSRYMSMLYTSNLRGNIPRSKKLQHTQWLPVSSNIGETEQKHPTLVDHSREVHSFAHADIRTCPFNTAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM60</accession>
    <name>A0A401GM60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0503450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614210.1">
        <property type="nucleotide sequence ID" value="XM_027758409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM60"/>
    <dbReference type="GeneID" id="38780214"/>
    <dbReference type="InParanoid" id="A0A401GM60"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="130" mass="15258" checksum="4815336EEE8AAE8E" modified="2019-05-08" version="1">MDGYQGQDESKSLLNSSSSMRVQAAEAEKQTKEGQDEELSPHECLRRLWLTRDRIAFACGFEGTNWLEMKHEMEKNPDVDWPKYVHKSLARWEVPLEEFRYILSMPEYFDDPADIDKLPVLVKFSCRQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMQ5</accession>
    <name>A0A401GMQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,3-mannosyltransferase CMT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0505440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614406.1">
        <property type="nucleotide sequence ID" value="XM_027758605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMQ5"/>
    <dbReference type="STRING" id="139825.A0A401GMQ5"/>
    <dbReference type="GeneID" id="38780410"/>
    <dbReference type="InParanoid" id="A0A401GMQ5"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF1">
        <property type="entry name" value="CAPSULAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="504" mass="57673" checksum="910230B0683A237A" modified="2019-05-08" version="1">MQPRSNNPLKRLPTWVSLSLGIFLGLLVARFFTSGSSITTWRGGHAPTYQSTRISSRQAVALPTLEQRRRVFELLTTLSPHYTKECTRNAQPMYKEQAEERYASLIGHESPSRSSWLDTLGLGSTNGDFVPRGLAPDTHKYFFAINLYNSFDVLPDLFATLFRVAAILGYHNVYVSIYENGSTDQTKALLRIFDALCRSSGMRVTIRTSMRTRGAFNHRIEYLAEVRNAAFVPLHELRDTENEYFDTIIFMNDILPCVDDLLELIWQSRHNNAGITCAADYMFHEDLNAPVFYDNWVARDINGTALENAPFESIFHHGASQHRFMHHLPIQVQSCWNGIAILDPAPFYTPPHVRFRMARIVDGECSASECSLICNDYWEAGYGRILMVPRVKLAYDRRVYDVIHPPRRNLTAIRGYVRLGGLPDNPRTDPQDRAWYGPHDRLFTEEEAIPVDFIPGPDFVWCWGWDGAGDLDGPDVDPIWERMSNKSIRPDAVKVRHDRRLSMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNN8</accession>
    <name>A0A401GNN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutamine--fructose-6-phosphate transaminase (isomerizing)</fullName>
            <ecNumber evidence="4">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0508920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614748.1">
        <property type="nucleotide sequence ID" value="XM_027758947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNN8"/>
    <dbReference type="FunCoup" id="A0A401GNN8">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNN8"/>
    <dbReference type="GeneID" id="38780752"/>
    <dbReference type="InParanoid" id="A0A401GNN8"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00528"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000001">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000002">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000052">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="376"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="12">
        <location>
            <begin position="548"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE83835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="698" mass="77074" checksum="7CA0E79E47D2B7FB" modified="2019-05-08" version="1">MCGIFAYCSYLQEKDRKTICEILVNGLARQEYRGYDSAGIGIDGDKPGEMLFFKEVGKVAGLRKRIAESNVDTTKTFLSQVSIAHTRWATHGPPSIVNCHPLKSDPKAEFTVVHNGIVTNSAALRLVLQKRGYKFESETDTEAVAILTKYIYDSQPDKRMSFTELIKTVLKELEGSFAFVFKSSHYPNEVVTARRGSPLLIGVKTEKKLKVDFVDVEVSGPEGEKMDALPSTAATSTLLAPPTQHGPNLLRSQSRAFMSEDGMPQPIEFFVASDASAIIEHTKRVLYLEDDDIAHIAEGELHIHRLRSSSTPGGAPPPSHRTIETLELELAEIMKGKFDHFMQKEIYEQPESVVNTMRGRVNFDKNVITLGGLRAYLNIIRRGRRIVFCACGTSYHSAIATRAIFEELTEIPVSVELASDFLDRKTPIFRDDVCVFVSQSGETADTILALRYCLERGALCVGVVNTVGSTISRETHCGVHINAGPEIGVASTKAYTSQYIALIMIALQLSEDRISLTERRTQIIEGLHKLPGQIKKVLEGDKGLQELATGVLANQRSLLIMGRGYQYATCLEGALKIKEISYMHSEGILAGELKHGPLALIDENMPVIIVMTQDSLYPKVQSAYAQITARKAQPIVVCNEDDDGIPTGCKTIRVPRTVDCLQGLLNIIPLQLLSYHLAVRNGFDVDFPRNLAKSVTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPK7</accession>
    <name>A0A401GPK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0601100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615045.1">
        <property type="nucleotide sequence ID" value="XM_027759244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPK7"/>
    <dbReference type="STRING" id="139825.A0A401GPK7"/>
    <dbReference type="GeneID" id="38781049"/>
    <dbReference type="InParanoid" id="A0A401GPK7"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="49"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="570" mass="59388" checksum="C03924370CC80A8B" modified="2019-05-08" version="1">MFSSLSYGSDSFLATEKALHLPLQLTQRAQKRDSQTCASGLGDVLDVTYSVLVDVGGTETPLVLDTGSSDLWLVSDGCHTSACVNSGVPLYPQGSLHSTGLDAQLLYGDSRTGTHALGPIGTDVTGVAGLSVSGQCFAAIADTNTTVLDTGSAGIFGLGFPPVSVIWRQLLETDISGAPPSLPRRSRLPPLELTTANSSSVSTDGSFIGRPPFPSFTFLSPHRRIRQVKASLSDPSALAIEAFATYGPFVTRLIAQQALALPMVAITLQRDTFEVGGNAGLLSLGGLPSGVQEDHLRWVPVRGYSADEGGLPPAPEASNEIYPLLWEIPIDDVYFDGTKLPRSTLSAPSISLSALMDTGNSLIRGPQDVVNNILAQLGGPTGSFDCDTPHNLSFEIGGELFPIDPRDFARPHTANNSANSPRCTGAVAATDPPGEGGFLYSWSLGDPFLKSVLAAYYYGNLTHPSQDPPRVGFISTVPDDAGEALREAVQAAISAGAIFPATSEPAPSGTYMATTTGPGGVPQATHLAASYSSNARSSNAARITDYADGWTSLLVISMNLGAALLGFACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR80</accession>
    <name>A0A401GR80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615628.1">
        <property type="nucleotide sequence ID" value="XM_027759827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR80"/>
    <dbReference type="GeneID" id="38781632"/>
    <dbReference type="InParanoid" id="A0A401GR80"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="142" mass="15514" checksum="C8BD71328ED4E8A4" modified="2019-05-08" version="1">MPPHRMQAGVLIGPAGPHGAPPAPSRLPPPSHALPASRPLTMHPAPGSRQLSNPMQPRPAPPMCSTGRGQGNVAQTLRSYGMHVVRQVDNAVAGPSCYMDVPRRNFNTDYGDFDMGECDKYDDYDDGVDGQYDEDAYYDRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRG7</accession>
    <name>A0A401GRG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0602920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615227.1">
        <property type="nucleotide sequence ID" value="XM_027759426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRG7"/>
    <dbReference type="STRING" id="139825.A0A401GRG7"/>
    <dbReference type="GeneID" id="38781231"/>
    <dbReference type="InParanoid" id="A0A401GRG7"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="9">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE84314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="95" mass="10818" checksum="E1A4329C5DC3B292" modified="2019-05-08" version="1">MSLMLLGKPLGTNNFVTMLYQMINDPKSAQFIMWMELGTRFVVSNVGEFSRSILGSHFKHNNFSSFVHQLNMYGFHKINCMSGPTHVYYCSPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRX6</accession>
    <name>A0A401GRX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0701610</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11 14">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="11">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615890.1">
        <property type="nucleotide sequence ID" value="XM_027760089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRX6"/>
    <dbReference type="STRING" id="139825.A0A401GRX6"/>
    <dbReference type="GeneID" id="38781894"/>
    <dbReference type="InParanoid" id="A0A401GRX6"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 14 16" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="15">
        <location>
            <begin position="36"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE84977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="314" mass="33379" checksum="1A434FEF5E4D725F" modified="2019-05-08" version="1">MKFVLISATHGRMTTPQVLGDLQANLFGGGLCEDQASEAIRLTFHDGIGRSAALQAAGMFGGGGADGSIIQFASVELADPANAGLEDTVYALKHFADAHNVSYGDMIQFAGAVALSNCPGSPRLPFYTRRPPAVAPAPPNLIPAPTDPVERVLARMEDAGFTAEDTVALLAAHSVGTQKTIDPTISNTPFDTTPRVFDSQYYLEILLRGTGYPGRGRSPAEVKSPLKSEFRLTSDAAIARHPKTACAWQSLIGDQDRMRASFSDAMMKLANQGYRNLVDCSPVIPSSRVWDRAPAYPLGKGVADIEQSIGILST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSA9</accession>
    <name>A0A401GSA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0703080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616035.1">
        <property type="nucleotide sequence ID" value="XM_027760234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSA9"/>
    <dbReference type="GeneID" id="38782039"/>
    <dbReference type="InParanoid" id="A0A401GSA9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019020420" evidence="1">
        <location>
            <begin position="28"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="124" mass="13762" checksum="E35F21FCA53495C9" modified="2019-05-08" version="1">MKGLFSGAEPMPPVFSALAALLLGAGAQIQAYLTCGEGVGRGMNWVWYFDARKHKDELWRWDDVVAALAKKPDGADLERLPVYVLDSFKLCKDYVRDHAGDGELEGWDSRRLAQEAFPWVASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSD3</accession>
    <name>A0A401GSD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial nicotinamide adenine dinucleotide transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0703240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616051.1">
        <property type="nucleotide sequence ID" value="XM_027760250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSD3"/>
    <dbReference type="FunCoup" id="A0A401GSD3">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="GeneID" id="38782055"/>
    <dbReference type="InParanoid" id="A0A401GSD3"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="76"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="193"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="291"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE85138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="396" mass="43866" checksum="AFAD5BF3A5567E4F" modified="2019-05-08" version="1">MVFTTDSKAEFVWRETALCGKNRLPASDVAGLVPRRLNHVQYTYNTSVDIFSSVQLEVERDCLNSTPSRPQARAMPSSATSMLAGAGGGLVASVATCPLDVIKTKLQAQQAINGQKGYKGVVGTVKSILRHDGIRGMYRGLGPTIIGYLPTWAIYFAVYDGIKDYFGEKPLGSPRQLYPAAQAKGYQPVTREHPWSLHILSAMTAGATSTMCTNPLWVIKTRFMTQPRQEIRYRHTLDAALTIYRTEGWRAFFRGLLPSLMGIAHVAVQFPLYEQLKRWAHEGSNDPLPPRKILFCSAISKMTASIATYPHEVVRTRLQTQKRPLVSNGSQNGSVSQYPPAGIVQTTKNIIVHEGWRGLYRGLSVNLVRTVPNSAVTMLTYELVMRYLSAREAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSI8</accession>
    <name>A0A401GSI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0703630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616090.1">
        <property type="nucleotide sequence ID" value="XM_027760289.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GSI8"/>
    <dbReference type="GeneID" id="38782094"/>
    <dbReference type="InParanoid" id="A0A401GSI8"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="828"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="750"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1255"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1271"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE85177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1288" mass="141364" checksum="4501F0C538158638" modified="2019-05-08" version="1">MSQTRLKIDTSVAGIAGPSFARGLTPASAHSSAYSSRSRSASSASASSSASGTTHAVSISTTPSSVVYVGVADPTACSPAGSSDSLTMDTVGEANEYVLAMHDFAPQHQNVTCLAFRAGQVIHVLNRDSSGWWDGELDGRRGWFPSNYVTSEVSLLTEEELPNHMRTRPGHSHSMSAVSATSWDTTASLREKTFYRTDHRPLAAESGMDTYCLPLMVPLLHGLSLLQNAAQANRIAHFQPSTACMISCVRAILSEVGCLPRDSPVLRRHGVLAQERKRILSDLASLVSQSKRASEGITNEELRELEAEAMVRVGGQLFAHVRGFLAVAVQCGITLPAQERHTSGSGGNGPWDSPEGTLVRPEDTVTPLPGEYDSYWEVSEKTTNAIERRSVMRYREDSGKGNPLSRAKSMGDLKTRRQIGIGLPLGPHNRSIGSTPPPRRDRASNASRIVKTIMSTHKSGQYSVSSVSSTSSFSSGESIGTPATPVFPSGPSNTAEVMEALRYTHDHYLSTIAAFIGHAHSHSRTSHASSTGHMYDLVREVVDMVCKLLTIVEAVLKHPDIPAHKAESLKAAKEGLYNVTSKLADSVRLLTVSPSPDVSEEEEKETLLRCATNALKAGSDCVSAVKKCLQRSMGERPFIIQLPLLGDTDAANFTPRKFTQQAIGHVQHLSKSSSLHALHELYTMNDVEGEDEDLTIQAQTFSSVETPIRPERRSADIPEEPAARAKLEISEEQEPMSTLQEDKPLPPVLITTESVEPDPPSPVSFAPTDDDRTTWEGSQRQLHSPNSLEEKLLNGDLPAVPNASLLTATPVPWTISHDHTPDDVAYNGDGQLVGATLAALVERMTPHDSLVEPPFAAVFFLTFRLFTTPIELVEAIIGRYNILPPPSLSDEDLYAWQQRKGLPVRLRVSNFVKLWLESYWRPATDNVVLPALVDFTRDALSGMFPVPSQRIMELINQWVVASEKGVDLKVERVRDAGIPLNPPSIAPSEVPRPIMTKTVLNALRNRNFASISVTDFDTLELARQLTTMECTLYCAIQPEEILETGQHGGTSSVNVKALTSLSTVITGWVAESILNELDTKKRTALVKFFIKLADRCVSLQNYSTPRSILAALDSSTISRLQQTWSGLAQKNKLQLEALRKLADHARNYSEYRSRLRNTAPPAVPFLGLYLTDVTFCREGNPSHRASPKSPEKKLLNFNKYHKLARIVQDMQRFQVPYNLKSIPEVQEFLKHLFEQSKHRGDLQDLYRRSLMIEPKQPADTAPASDVRQLFNWASRSQPSQHPTPTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSQ2</accession>
    <name>A0A401GSQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0704320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616158.1">
        <property type="nucleotide sequence ID" value="XM_027760357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSQ2"/>
    <dbReference type="STRING" id="139825.A0A401GSQ2"/>
    <dbReference type="GeneID" id="38782162"/>
    <dbReference type="InParanoid" id="A0A401GSQ2"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000728">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="957"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="597"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="729"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="251"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="648"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="754"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE85245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1011" mass="105228" checksum="FF1CB1FE05249366" modified="2019-05-08" version="1">MGQSVSRGRPPSTSSPLAPHAEASGTAQPELSSSQPSSEAAAIPPPPSTSTKRSRRSSLRHSILGLIPSSHSSASLSSDSTQPPKKRWRSSRRWSKAPTQLADLSESAPVSTVQTNSVGPPDFPDDNGTHGSSVPDSPIGGLPEEERLSRDAVVQSEETSHVVGNEFAGDEVSTGDEEVHRGAAEVADGVDAIEASGTAGIVSQTHDMDDEGLQSDLATAETTQTAEPAPQLARQFPPPGTLVVVQGVVNTTDAPSTQAPSSSSRPARSTAPRPNSVFSSVPAASSLRRSASIPSSSGRNREERQGGRNRFSAFIPRPGSMLSGRLSSDANRVASQEGIPPRNSIASSDLPSNITHDTASVADSYMGGHSVEENDSQSSESDGRPRPLSPGSIDVLGTLLSVAAAATAASLFSPGLAMSVNGGANNVPQPFNRPMSPTPTAGLGNLAGLGGLTGLGLHPTSNPHGVAQAQRDGRDRIRNVWESFRDRLGLNSRNPGYSPFSSDGQAAASDGDARMRPGELMLAEMARALNIGLGLNGDSTTGPQPSQQGDDVESSTTFGSAATASGPESGDNTLPPEDSFERFLINLQADLRTALLEDGAPPSDEAGGAPDVHTETGEEAEAEPVADPSPLAASASPASEEIRSEPSSEVDDNDEPPPLADDSDESDSEDDGDEAMDDAGDDGAQPSRRTPTPIPNTEGERRAPGINLWRLYRFQPIPATQTQVHIASTSVGLPPNPAPEGDATTQTPHPPSPTFSVSDPSSASPSESSDSAPTPSTSTDPNANVVVPVIVVGLQSVDMGQAQGHAHGGADAVFSPEDIRTAESRAGSFDGIPGEGTAHPPRGRTWQSRAANAFRTLRPGRRGGSGGRPTSEATGSRTFLIYVIGGYYPPNHHMVTGSDSLDSYEALWELAELLGQVKPPVATKEDIDNSGLRIIQTSDLIEYEKEGRVASNCVERCLICLDEYGSDDSLRLMSCKHAFHMDCVDKWLQVGRNNCPACRTKGVSTAGDSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT84</accession>
    <name>A0A401GT84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspyridones efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0706350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616361.1">
        <property type="nucleotide sequence ID" value="XM_027760560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT84"/>
    <dbReference type="GeneID" id="38782365"/>
    <dbReference type="InParanoid" id="A0A401GT84"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="44"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="432" mass="46833" checksum="0ABF74F4AED24E62" modified="2019-05-08" version="1">MADLEKKLTLENTDYCSSPADKTSRPDDHVHETALPDGGLKGWLTVLGAFLALLCGFGQLNSFGTFQSWYAEHQLWDKPASTISWIGTLQLWIFFFSGSFLGRVFDAYGPRILTITGTVVLVVSIMLTSLCTQYYQYMLAQGILFGLGVGMLFYPSLSAISTHFTKRRASAIGLAMAGSGIGGVMYPIILRRLFAEVGFPWAVRISGFISLALCLVAITTVTSRLPAGRDSGPWINASMFRDVPYVLVVVSGALISLGLFIPYFYIVDYAMAHSIPATTAFYVLSVMNAGSVLGRIAPSYLSDMFGRYNLIVPCSFLAGLLPLVYWIFATTLPAIMIFAAIYGFFSGAFNSLIIPCVAQISKTGEHGRRVGMLYSVISFPALCGGPAAGALLRLQHGSYSGTIVLSGVTMLVGSFFMLWARLTIDPRLSARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTH1</accession>
    <name>A0A401GTH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0800230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616419.1">
        <property type="nucleotide sequence ID" value="XM_027760618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTH1"/>
    <dbReference type="STRING" id="139825.A0A401GTH1"/>
    <dbReference type="GeneID" id="38782423"/>
    <dbReference type="InParanoid" id="A0A401GTH1"/>
    <dbReference type="OrthoDB" id="2804161at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="23141" checksum="6937DC26A3A5257B" modified="2019-05-08" version="1">MTNTNSKVYFSHWIQVHQLKLINVDYLMALMLRGAAMQCCPTQGAIDGIIPFLLQGYSIVEDNIGVIVWQCKNDSHYTANPKPDMFDAMDPYELGIFDLSSVPIPIIRIFFALAAKTPCVKYVTAKKSIQNKKYTAYDFWVAGLSPTVFLPVKQTNWHVWAALLQASYGWQEIYEEQRLHKELWQSQIPAAADDPAHWARWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTP1</accession>
    <name>A0A401GTP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Interferon-induced GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0801100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616505.1">
        <property type="nucleotide sequence ID" value="XM_027760704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTP1"/>
    <dbReference type="STRING" id="139825.A0A401GTP1"/>
    <dbReference type="GeneID" id="38782509"/>
    <dbReference type="InParanoid" id="A0A401GTP1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="35"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="648"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="742" mass="83798" checksum="0B8F2C00036B7A11" modified="2019-05-08" version="1">MGTSSDTVGQTAYAQKRREILSFAKDLRAMGAESEIGMPRIVVIGRQSAGKSSVVEAVTGVGVPRDSDTCTRCPMECTILTAERWSCRISLRLLNSPETPFSPILTSKAEVELWIRRAQAAALCPIRQGDFIDKTADELRSLVGVDADVPKFTRNVVVVDINDPDGTDLSFIDLPGLISNEEQNIIDLVRSLVEFYIKDEATIILVTIPASDDMALQEAARLAREVDPNGERTIGIITKPDFLPDGAIDLRKTWQSILRGEAHPLRLGYYGVRLPSDKERKKGLSRAEVEKLAMQFFKDNEPWKDLLHLNRLGIACFIADISKVLMRVIRESLPGLKEKVNTQLGDCVTQLNSMPKPITGGATAEILGRVTRFCNDLKEAVNGHTEDNTFVHRNRAIYQTFKISIRRTAPDFRPFLDPTQFVGPKQPWFSEEYEDREDTELAEQLPPAPVEPIGIYDVRRVIKDSIGWELPHNVPYEAKKRLYKKFVDRWAAPCDKAFDAATVILTELVNDKIRDHFGRFKALELHVGPLIRRELQSCTKRAAQSLCEVLEREKSPYFTQNGYYLESMRAHCLARYWFIRRNENDYKKGALWDLEREEELAASVFAESDSYHESPTERALKALALIGYKNLAAEDLVRLHPPDGFEDELTVMADVRAYFQVAYKRIIDNVPMSIQKDLNQQLSNGMQDCLLAELGVGAAGTAERFQELLAEDPAVTAQRDLLEKRKARLLEIQWKLNAFVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTQ4</accession>
    <name>A0A401GTQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0801290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616524.1">
        <property type="nucleotide sequence ID" value="XM_027760723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTQ4"/>
    <dbReference type="GeneID" id="38782528"/>
    <dbReference type="InParanoid" id="A0A401GTQ4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="114" mass="12296" checksum="A296C1FDCC9422D8" modified="2019-05-08" version="1">MQLRTSSSFLHLGCGAAVGRMFAQQHLMHLSVRRPTGLAAREHMRRPKHPPHTRLFPLMQSVARAGQFRRMLLDFAFVSGLAASLTLRGSRSGAPGGDIVCAAAPHVSVNAPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTV0</accession>
    <name>A0A401GTV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0801720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616565.1">
        <property type="nucleotide sequence ID" value="XM_027760764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTV0"/>
    <dbReference type="GeneID" id="38782569"/>
    <dbReference type="InParanoid" id="A0A401GTV0"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="488" mass="55577" checksum="C2386872D44D7737" modified="2019-05-08" version="1">MELPGGSNVASPPSSRCSLERRVEDTVNAIDWEALSAIACKLHRVQSARWGDQLWGGYNVVRFLHLDNADKTIIVARVPHRPSKGYMPEHARAISNRISSEVATMEYVATYTRVPIPRVLHFSAEVDPLVGSPYILMSKVDGVCLSTLWDSMTDDNREIVLRQVVDILLELSNQRFDRIGALFKGDGVGKAAWCVKTASSFASPEDEIESSAMASTYSSGVEYWTRYANAMLQRIHDNKFGNRGKEYDYVQVWFLRSLIPQLYDPSLDRDGFPLYPSDFHSQNIMVTFTDSKPVISAVIDWEGSTTQSIVTFAHYPLFIVDHPFWDDDHPLRLRNVQDQATFDRLLREAEQNANPGGSLLLSCLFSNCLGVYLFEQAMQFPGLIRDVIYPQLFAHVFGIVEDEEEKFQTEYYWALLEKGILKKLTSQFRRETEVWHEAMNVLGTDVVPKNLRRDQFRAVILEHADQFDVDGQVRQWLATEDPKPVSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTV1</accession>
    <name>A0A401GTV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0801750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616568.1">
        <property type="nucleotide sequence ID" value="XM_027760767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTV1"/>
    <dbReference type="STRING" id="139825.A0A401GTV1"/>
    <dbReference type="GeneID" id="38782572"/>
    <dbReference type="InParanoid" id="A0A401GTV1"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="688"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="814"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="842"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="3">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="2">
        <location>
            <begin position="492"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="876" mass="99570" checksum="3D4004934A790567" modified="2019-05-08" version="1">MDYDAYDALLHYIFKQTQGDAWFKPTEENLHVGVCLRVDNGLFRIFPYENSYLEPFEMAVRALNPVVAIKTRSAAVHAALATVTEDDTAIYIDRDTRIQIVETMLLLPRADREQCAAFIRDERVLVVWSYNLDTFVPTCIDFQDKLVQLVWKQRASIPSLTNSVVASTSASYDNLTEKVETAINEKEVVAIAKEKETTQKPRTCAINIFRYWVSDKDDVEKRAEGPSYRPTRLFGPVYAGFAAALSIFFVASGITVLLQEMVLDGSYTRFALLATAPFLFSVSLFFSLQIVTNLSYIFGPVSQFHENSKYYSAVPPGPNKVVDGNLPHITIELPVYKESLKETIGPSVYSIKKAMQTYARQGGTSSIFVHDDGLQLISEEERKERVAFYADYNIGWVARPPHSNDPDGFKRPGRFKKASNMNYGLALSLKLEKHLLALEADAAARGLDASQVEGECLEDKAMNLAVEEIYEESGKRWRPWAYNGKSLRVGEIILIIDSDTIVPEDCFRDAARELSECPEVAIIQHESDVMQVAHHYFENGIAHFTRRINKCISMGCANGEVAPFVGHNAFLRWSALQDAAFIDPADGLKKIWSEVNVSEDFDMALRLQLKGYIIRWATYSKGGFKEGVSLTCDDELNRWQKYSYGCNELIFNPFIEWWRKGPVTKQLHTFIWSQAPVHYKITMMAYMFSYYGIASAIILSTMNYLLLGWDITIDGYYEHSFEIWLACTVVFPGAGNVGFTLLEYRLGIRSLFDALLENLTWIPFFFFFFSGLSIHLTQAVLAHLFSYNITWGATKKEVERSNFWLEVPKILKRFWLALVVCIAICAAMIILSTSLIPEGWQIYSWNWAVIFPLAINAGCHILFPIVLNPWLMIFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU12</accession>
    <name>A0A401GU12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0802430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616634.1">
        <property type="nucleotide sequence ID" value="XM_027760833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU12"/>
    <dbReference type="STRING" id="139825.A0A401GU12"/>
    <dbReference type="GeneID" id="38782638"/>
    <dbReference type="InParanoid" id="A0A401GU12"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="23532" checksum="D288559DA9C31D28" modified="2019-05-08" version="1">MLQYRLYNGAVPPASLQGFLKVSKNIGSVIGQFIFSYYADYLGQKAVYEFIVVLTSPPQVLSSGYPSFVVSSALALAVATPCPPPWQATALPEHILLVYILVNQGWGSLIGGIAVIIMLACYKHVVEVEDEMSKVDGIWHILVGLSLIPMFSMLYQCLTLPESKQFEASQKNADIEMELINVLKKKASPENSITEQMCSLTAPSPPLLRCPHRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU34</accession>
    <name>A0A401GU34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616613.1">
        <property type="nucleotide sequence ID" value="XM_027760812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU34"/>
    <dbReference type="GeneID" id="38782617"/>
    <dbReference type="InParanoid" id="A0A401GU34"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="218" mass="23780" checksum="9FAFC0831782E14C" modified="2019-05-08" version="1">MWNMQGIEHRNKTNYRPPSATPREKRTVHFKSRSRRQSDGPVSNTPEHFLPPPDDPKPVGAISPTRAYTSGAATNRRRRTPQAPKDRQATDSCLPTEAGQRPPRICVLYLRRAAAASAWDNISPQVGYKASAHLHALSSPLLSASPKTLPTLVALTTLAPVDMQLNALTLILATLACTGVAAPADMPLALRVAADSRSARYRDTVAPFDLPWHSPQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUA0</accession>
    <name>A0A401GUA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616676.1">
        <property type="nucleotide sequence ID" value="XM_027760875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUA0"/>
    <dbReference type="STRING" id="139825.A0A401GUA0"/>
    <dbReference type="GeneID" id="38782680"/>
    <dbReference type="InParanoid" id="A0A401GUA0"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019331160" description="FZ domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="50320" checksum="6F9484D7FD9DD936" modified="2019-05-08" version="1">MRSYMRLPRTLLCLLQAFLVVAQPPQLTLNHGVYNFSSSTLPNPPTFKLPVSNPLYLSVALCSAQTTLPRLFVTNDSTASQPGPAELGQANVYEIPLEDGLGVWSGPMNVQGVLAIYNASQSLSFEIGLSNAGPIHQILDELPLLGDTTSNQVLLFSPPFSPPEISAPTYPNYTLPAANLTFPPAPPSPSNYSVFVTLTSTTPLPLTTCALNVAQVEGSLYDSPSSVSSQGLWLRDTDGWRWQWLINGLLPQKNYTAYAILNDTKVSGPINFVTKSASFSCPLVHSLPFCPAVAYAAPLPDLTNNPALGATAGDLPDSLTGPLLSGLANFTVMLTTLACGRDKYSQLVTCADCQTAYRAWLCMVSFPRCGEYPSSTGTSTQPALQPVAPSATPRNPSLAPFAESYDAMLPCLETCNAVDRACPPFLGFRCPVPQFTAGDSYGVGFIDSGAQGVMGGGSTGAAADRWGNVWCNMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUB5</accession>
    <name>A0A401GUB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616237.1">
        <property type="nucleotide sequence ID" value="XM_027760436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUB5"/>
    <dbReference type="GeneID" id="38782241"/>
    <dbReference type="InParanoid" id="A0A401GUB5"/>
    <dbReference type="OrthoDB" id="2802942at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="59" mass="6757" checksum="9C092A12A018C9EC" modified="2019-05-08" version="1">MQFNASRAGLLTAIQTDLLEAQRPRPVRAELYKLNVYGPKSFFKSHVDTPRSEAMFTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUF8</accession>
    <name>A0A401GUF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0803580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616749.1">
        <property type="nucleotide sequence ID" value="XM_027760948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUF8"/>
    <dbReference type="STRING" id="139825.A0A401GUF8"/>
    <dbReference type="GeneID" id="38782753"/>
    <dbReference type="InParanoid" id="A0A401GUF8"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="34005" checksum="B8641051C4A7E73B" modified="2019-05-08" version="1">MDQLFPPKPKWTFADIPDLSGKVIIVTGGNAGIGKETVKQLLLHNAKVYLAARNPQKAHDVIEDLREQTKKKAVYLELDLADLKSIKAAAEEFTSKEAELHVLFNNAGAMNVPNDQLTADGYDGTFGTNVLGPFYFTQLLLPILSLTAKSSPPGTVRVVNSTSVGHVFVRTVDLDTLKDTAARRRMSTQTSYYQSKFANIVYTNEFHRRYADRGIVCMSVHPGMIGTDIWKGSAAWLNLSVNVLFLHPVWKGAITQLWGATMPEGATFGGKYLIPWARVGAAKRETNDQELGRKLWELLEEQISLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUQ8</accession>
    <name>A0A401GUQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0804470</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616836.1">
        <property type="nucleotide sequence ID" value="XM_027761035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUQ8"/>
    <dbReference type="FunCoup" id="A0A401GUQ8">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUQ8"/>
    <dbReference type="GeneID" id="38782840"/>
    <dbReference type="InParanoid" id="A0A401GUQ8"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="288"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="513"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="611"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE85923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="677" mass="74928" checksum="5CD7D40249868E7D" modified="2019-05-08" version="1">MTVCTDCGGTVIEYDAAAGNGFCVQCGTVVEENTIVSEVMFGETSTGAAMVQGSFVGQGATRARMGGPFGNRGSSESREQTIANASRKIFQVATVMRLSEVVSLAATRLYTLAVEHKFTKGRKSMNVVAVCLYVACRQKETRNYMLIDFSDLLQVNVFELGHTYLQLVQTLNLRLPLVDPSHYISRFAALLEFGEETHQVAMDAVRLVQRFDRDWMTRGRRPAGICGAALLLAARMNNFRRSIAEIVQVVKIADTTLKKRLEEFKCTPSGALTLADFRSVWLEEEMDPPAYTKGKEREEKDKEGQDNDGKKTKKGKGKGKGKRKKRKRGEEDEGEADDEAQDEAHEGEEIEVAPEPLPHHQIDPALLNQGILTGTTQPPLFFPEYDETDSNIDPALLDHEHPSAPPPIPMPQNLLPDKVLEMDLPPPSPMEETVNAVVAEEVSDFLANAQGAVLSSALAEAEQRRLEHFIGDDELMGLDEDELDRFLLTEEEVKIKERVWVEMNREYLEAIAARGDQQGEAKDKKSRKRRKTSNKPRDASTPHGSTAAESVRNLLKKNPKYSKRINYDALKDLFTESTIKTPSTPGLDDKDDGLYVMDDKSDGEGMLIVEEGGGGVGMAPSQSRNVTQRAPVADTHQSTEYVDLGEADEDAVGEDDVEEGSDKGEDYGEWDAYEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV86</accession>
    <name>A0A401GV86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616567.1">
        <property type="nucleotide sequence ID" value="XM_027760766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV86"/>
    <dbReference type="GeneID" id="38782571"/>
    <dbReference type="InParanoid" id="A0A401GV86"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="488" mass="55729" checksum="20DA16C0740A7D1D" modified="2019-05-08" version="1">MPDEPEHTSIPSSKCSNSLERRVEDTVNAINWDALSAITCKLHQVQSAEWRDPLWGGYNVVRFLHLDNADKTVIVARVPHRPSNGYTTEHSRALSNRISSEVATMEYVATYTRIPIPRILHFSAEVDPLVGSPYILMSKVDGVPLNTLWDGMTDDHREIVLRQVIDILLELSTHRFDRIGALFKRNGVGKDAWCVQSASSFASPEDRNASSAMTSTYSSGAEYWMHYATTTLQRIRDNDFGDRAKEYFYAQAWFIRSLIPHLYDPSLDCAGFPLCPGDFHSQNIMVTYVDSKPVISAVIDWEFSTTQSVVSFACYPLFIVDHPFWDDDHPLRLRNVQDQATFDRLLREAEQNANPGGSLLLSCLFSNCLGVYLFEQAIQFPGLIRDVIYPQLFEYIFGEVGKEEENFRGDYYYALMEKGILRKPTARFERETEVWSEAVKILGEDVVPSDLNRDRFRAMAQAHIDRFDVDGQVRQWLTAEDPNPISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVB0</accession>
    <name>A0A401GVB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617084.1">
        <property type="nucleotide sequence ID" value="XM_027761283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVB0"/>
    <dbReference type="GeneID" id="38783088"/>
    <dbReference type="InParanoid" id="A0A401GVB0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="62" mass="6788" checksum="38F71DD564D74B84" modified="2019-05-08" version="1">MLPDQRIVMSVRPELCQACLGIDSQNDDSMNGMNGRHDVNGHGSETETEAETETSGNEPYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVJ9</accession>
    <name>A0A401GVJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0901150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
            <location evidence="1 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617149.1">
        <property type="nucleotide sequence ID" value="XM_027761348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVJ9"/>
    <dbReference type="FunCoup" id="A0A401GVJ9">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GVJ9"/>
    <dbReference type="GeneID" id="38783153"/>
    <dbReference type="InParanoid" id="A0A401GVJ9"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE86236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="12235" checksum="AB840631FC58940F" modified="2019-05-08" version="1">MAEKLDTLTSSTDTGSGPKEAGTSGPRAIVKNVDMSEDMQQESVDIASAALEKYNIEKDIAAQIKKEFDRRHGPTWHVVVGKNFGSYVTHETKHFIYFYIGSLAILIWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW31</accession>
    <name>A0A401GW31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0902710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617305.1">
        <property type="nucleotide sequence ID" value="XM_027761504.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GW31">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GW31"/>
    <dbReference type="GeneID" id="38783309"/>
    <dbReference type="InParanoid" id="A0A401GW31"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1226"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1261"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="610"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="734"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="1110"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="866"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1333"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1341"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1384"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1456"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1475" mass="158709" checksum="5D1CAD12A1792C8B" modified="2019-05-08" version="1">MPNGRERHQSQRSELASSHSSSPLRTAASFSSSNHSQAAPSTQAITAEALLAAYASAPHPSLAALDAAVAERNTLSVQNSGLWKLVEKHRTAYNQIMKELERVRSEREMYRSRLQRTGENTDKLLRAHREKEKKEGSLRSAVSQTHLRNSESGSSNTSGGALDPRGHIVRAYSDNTAPRLSQQQQQSQYSQHRSRDPLTEAHSSQTSLNSIPQVLVPGPSSRSSGQAAQSSQQPTHPSRPRESPSQLQVNHSGPNNARSGHAATPSIPSISETSSDGHKRPLHSLSPTERSFSSSSQALSTSTSSATAQMADSVPKLDVADPVLGPYAPMQPPPDSVRPVASVPPQVAAVVLTPPTPSPRSTAAMAALNGRAVPVPPSPLRTNFQAPQQPASSSSLSPLSNVEPSRPYALSRESRISLPEEAKRYYATMADSPKTSPAIGNFEVGFSSGPGSPLKAQAGHSPESPHTPGKLQVTTEENAPFLDMGDEDSMYGSVGGSVRDGSGQNSNVEDGYPEEEEDPYDPADENGDTVGKRGRGTNKRAVVEDFPLPPSTPPYAPTRTSGSRSRSDHSHLQAPAEPHTPISPFPIPLASTPPQMTFRELPLLASDLPNTKIQVVNSSIRPNDRGKEVLSFAILVDPGKGKDPWKVEKLYSDVLGLDARMRATVGKNVGKKMLPLPEGRLWRDHAPAKVDQRKSALELYLRSLIALPVKNKDEVIAFFTSDMVRETQKPVAQAGYKEGYLTKRGKNFGGWKTRYFVLQGPSLEYYESRGGAHLGSITITGAQIGRQQRAPDRKESDEESEYRHAFLIIEARKGPGGSSPRHVLCAESDKDRDSWVEELVRYVSGTYSEDQIPVVHSWGSAAAMGGATQQDAGNQPRMSTSSASIYDPPSAQSTPVRRTRDAAKCGNPKLSSDGGSMKPLPHIASYGDESMSSGPAKSSVMAPSPVDQVIAAEMPMSTSLPTSSPLVADDVDLVQPISQRANSELGNYPDLVDQRPVRGGNLALDRRKMMRMSVNPLKTAIPERTPSPEKDAGQHTPRVDVNGKVKISAPMNGTLIPAGYKFGGKDAPSESSVSSNERREKAKSRGFWGLVRQHDKPNVPTHIPRAVFGISLEDSLEVAELASLPAIVFRCIQYLEAKKAEQEEGIYRLSGSSAVIKALKDRFNTEGDIDLLSSDEYWDPHAIAGLLKTFLRDLPSSILTRDLHLRFLAVIDFVDPQERIKELSRLIASLPIANYSLLRALTAHLILIVQNAHVNKMTMRNVGIVFSPTLGIPAGVFSLMLGEFKRVFNVDSTLEADGDGEPSRRGQGEQEPGLDRRNSRHYTDAAADQLLGLSGRALPVTDEDTPSDEGEEASLAEESMEGTTENESDIVESSATSSSAHLSYGQQPSSDSLNVPTADQGGLSPIPRSRAAHLAASRGLNISTPTDKASRRRSHVVGLPVSPRPSPRTPNTGGAPSPPPIPPSPLPGGNSSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXB7</accession>
    <name>A0A401GXB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1000990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617770.1">
        <property type="nucleotide sequence ID" value="XM_027761969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXB7"/>
    <dbReference type="STRING" id="139825.A0A401GXB7"/>
    <dbReference type="GeneID" id="38783774"/>
    <dbReference type="InParanoid" id="A0A401GXB7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="7">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="160" mass="17813" checksum="98568EABBF4DE45C" modified="2019-05-08" version="1">MSSRTKRRAETAESEKKSRSKKAKRDVEEEDVEDDSEESIEEDELEALQQSNIITGGRRTRGIRIDYTKVQGFNDADEDDEEEERPKSNRGKAALMSASGSSSKSKKAAPPPSPTKGKAKAPLPRARVVVSDEEEEEEEVEHNDKGDEDEGGDEDEDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXJ1</accession>
    <name>A0A401GXJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617792.1">
        <property type="nucleotide sequence ID" value="XM_027761991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXJ1"/>
    <dbReference type="GeneID" id="38783796"/>
    <dbReference type="InParanoid" id="A0A401GXJ1"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="538" mass="59673" checksum="74B6FD6901F02285" modified="2019-05-08" version="1">MSSHLSALTLASDATVVSQYTPDEYERTSYYNGITGDGDHPELVYRSDFLTTPFPKPVGRHAHIPVKSLRGVFDTPLNGVWDTVGPKICDLIKARKINWSSVDPARFFTHGPLGEEEKGSLGPVVIWVGVIPGSTSSYIAHEVSQEILTLLLKNGVEDAVVEWREAVLQRLAGPPLMRHVGSNNATHYVRRFLTALLGVPLATALATEGMEVEDAQGALTLWFHENKDKDGNSSDKVYGVGNCHVLRKDTTVEYEHRGGAPKDHVRVCGMHRFQRGLDEIKKVIGDRGILADLWAREIVTLQAKERQDAENAKEIRANRRNLEDENEAIADLEAFYDEVTKYWSDINLYRNIGYAKVKDEFEGNVVDLGFKYSPQELSAMFYPLGGGATTFKFPEERKLRIEGCATKEDLANPAEFDSEGQRFLIVGKDGNTTDLTVGRYAGLVSFTLNEVGIESIELGIYNSGVKSAEAFSAKGDSGSLVWHTTNGKARIVGQLHSGNNKGGSTSNHVTYCTPGWYFLDQIRKKFKHADFYCTNWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXQ6</accession>
    <name>A0A401GXQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1002330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617900.1">
        <property type="nucleotide sequence ID" value="XM_027762099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXQ6"/>
    <dbReference type="GeneID" id="38783904"/>
    <dbReference type="InParanoid" id="A0A401GXQ6"/>
    <dbReference type="OrthoDB" id="2804239at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="134" mass="14254" checksum="0E66B2023A17EA20" modified="2019-05-08" version="1">MSASSNPERDEHVRTLRQALYSIIAPKRPYYHRSSSSASGTVSPTPTPVSGAHTDHPATPHHQQYHPSNAGSPVPNAHADTPPLQHSPLAPAPPVSPGTVAVPIPHDAPHTRPDFIGTLQSKSAWDALIHGSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYH9</accession>
    <name>A0A401GYH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SCP_1002700</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617937.1">
        <property type="nucleotide sequence ID" value="XM_027762136.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYH9"/>
    <dbReference type="GeneID" id="38783941"/>
    <dbReference type="InParanoid" id="A0A401GYH9"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="23" id="KW-0862">Zinc</keyword>
    <keyword evidence="23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="25">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="26">
        <location>
            <begin position="515"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="752"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="GBE87024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="29">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1425" mass="159699" checksum="CE355B8B47626BA4" modified="2019-05-08" version="1">MSSTTESRDSLSSLFRIEQLRDDNWLPWKRRTMAILRERGVLKYVDGTSEKPKPANATTPTAGETAVITKWVEGDQKAQTVIELLLSDSQMIHIADATTAAEMWNQLKLVKEASGQLGIMAYRRKFYRTVATEGSDIAAHITELRRTQEQLHMMGSKVSDDEFRTILITSLPESWDQFTSAYLGATSQKDKLPTSHELIAILLEEYRRRREKGGADESALAACGRWTQPKNTAQGGTDRKSDAECWNCHKRGHTQHECWSKGGGKAGQGPRSKKEGRAQAHTNQAQSTNDVLRDVAFRTDEATCAGQQFSSQFSRYDWLADSGTTSHVTNLRDTMTDYVPLEASSIAGIGDQSVRALGRGTVEVNSRIRGNTCTFCLKDVLYAPKATNNLVSLSRLDEAGGHFDGGAGGIMLRESSGHIIAQGRKVGRLYLLNMRAKAAMPSEERANIARDDSDSWESWHRRYGHLGFTGLEKLYKENLVEGLTVDENSMPLTQCEACVQAKQARRAYPKEVEDRSQMPGELTHSDVWGPARVVSIAGSHYYISFTDDCTQRCQVLFMKHKSEAFEKLKEYLTFIERRFGHLPKIVRVDNGSEYINKNLKGWCREKGIELQTTAPYSPSQNGVAERFNRTLLELARAMLIARKLPNFLWAEAVAYAAYLRNRAPTKALCGKTPEEAWTGKKPNVAHLREFGSDVWILTEGQNLSKLEPKSKKHTFVGFADGPKAVRYYDVGARSIRVSRNFVFADALNPASNVPVHQLDDSDRLPLEGESGGAVKQQPPTSASKPASVPVKADQSNKKHDGNYITEEDLPPEIQESMRERPTFLPAPPKIPLRRTTRATQDHDYRRMNNPRAQPTKSREPPGVPKENAPGESAKVAVMPEEFEEIAQALYATALASGDRTASAGDEPRSLAEAQASPEWPEWEKAVKAEYDQLQGMGTWELQDLPKDRNAVGCKWVFQRKTNKEGQVVKYKARLVAQGYSQIPGMDFLETFAPVVRLESIRAILALAVVNNWEIGQMDVKGAYLNGDLQEEIYMRQPEGFDDGSGRICRLRKTLYGLKQSGREWNRKLHRELTELGYKRLEADPCVYLWERKEGEVQIITVWVDDLLLFTNSPKLMEELKRDLQDLFEVTDLGEPQKIVGIEIERDREAGKIQISQQHYIESILKRYQLENANAVGMPLDPNVAFTAEDENEEADDRLAGGYASMVGSLMYAAVGTRPDISYAVQTLSKYTACPRPVHWTAAKRVLRYLAGTRDLHITYTRRDSDAPNGNIIGGYTDTDYASDHDRKSVSGHVFYLGGGAVAWSSKKQTTTATSSTEAEYTALAHATRQAIWLRNLLAELGFAQEEPTEIYCDNQAAIAIARDPQYHARSKHFDVQNHFVREKVENGIIQLCYCPTDEMVADVFTKALPKPKHQKFTLELGMLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYL0</accession>
    <name>A0A401GYL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1004890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618155.1">
        <property type="nucleotide sequence ID" value="XM_027762354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYL0"/>
    <dbReference type="GeneID" id="38784159"/>
    <dbReference type="InParanoid" id="A0A401GYL0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="176" mass="18632" checksum="F1BB60DAD0BBB6A7" modified="2019-05-08" version="1">MTGCMFLRSPLYTPAKHNPHKLQLLAEADLALVEGADARLLEIEALADTEPETEAALLEAEPDAALLLVEAQADAALLDADGDASLLEPETDPETEADTEGDIEDTALALESTEADADAAEDDTAEDTADDAALDCAVTLVAAETTAASAANLGDRRRRILPFAREKFRECEVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYZ8</accession>
    <name>A0A401GYZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1100550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618293.1">
        <property type="nucleotide sequence ID" value="XM_027762492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYZ8"/>
    <dbReference type="STRING" id="139825.A0A401GYZ8"/>
    <dbReference type="GeneID" id="38784297"/>
    <dbReference type="InParanoid" id="A0A401GYZ8"/>
    <dbReference type="OrthoDB" id="2799149at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="127" mass="14363" checksum="C8867AB57E7870C5" modified="2019-05-08" version="1">MAYISKADRIDLDDQIGLQLGTKGSRTRINYGARPTISIGPVKAQHYLDVVDIDRYDAVLGTVFMHKYGVVLDFENRTISIQWQKIPTYVEVDKATIIANRKDMSHSHYRVHNNVSTVTAITSDNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ01</accession>
    <name>A0A401GZ01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618295.1">
        <property type="nucleotide sequence ID" value="XM_027762494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ01"/>
    <dbReference type="GeneID" id="38784299"/>
    <dbReference type="InParanoid" id="A0A401GZ01"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="50" mass="5680" checksum="DCF97DC7B417A0D1" modified="2019-05-08" version="1">MVEGPQCHPGDTDLEDNGYRDPMDRLHHHCLLDQRDLQDLNTPVGRKGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ28</accession>
    <name>A0A401GZ28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1100940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618331.1">
        <property type="nucleotide sequence ID" value="XM_027762530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ28"/>
    <dbReference type="GeneID" id="38784335"/>
    <dbReference type="InParanoid" id="A0A401GZ28"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="116" mass="12537" checksum="9B692A66FEB69664" modified="2019-05-08" version="1">MTRAMNNVFVLVQPVYLKRAFPSNITEHLDHVSIATAHDIINLVTADPTALHFVAVGASDYLQLKTSTHLTLFSVVSSVTHSDLISPSGHSRQLCVAPSALTWPHVATVLGAILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZB2</accession>
    <name>A0A401GZB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1101840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618420.1">
        <property type="nucleotide sequence ID" value="XM_027762619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZB2"/>
    <dbReference type="GeneID" id="38784424"/>
    <dbReference type="InParanoid" id="A0A401GZB2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="167" mass="19119" checksum="A723D7D5574EA657" modified="2019-05-08" version="1">MEAVGYADALIMRLLSNVRTLRRRVRDRRVFGVAELFLLASARVSGAALTEACDTRWSPASDPPRRRGRRLCVYAFMRFPPEILPAVFSKTPLRYELRHSSAGDGAKAHAGLRNVLSIHLARSQFLFASFSRLVSLPLKRGMWERPPERSCETRLLRRTERRLTVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZD3</accession>
    <name>A0A401GZD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1102010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618437.1">
        <property type="nucleotide sequence ID" value="XM_027762636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZD3"/>
    <dbReference type="GeneID" id="38784441"/>
    <dbReference type="InParanoid" id="A0A401GZD3"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="39374" checksum="ABF6E01FC1323D5B" modified="2019-05-08" version="1">MDPGFSTTRRSHTRMSEDRVLLQLCFIRVSISVSMPQQSSVRVIHAAITPHHIADRSAAGKGKVDEKVNSKVKAKPLPPAVIPSVSTYRSIVSAAQETDFMALILGDMDSFLAQAGGSLCKRKTRPEPVYDKPRTSPPRATGDHRDSHPDYFDALSDRINDNGVGLSSDDQFLSPKEKMRKEAIDMTPATKRLERMNVHSGTDEGDTSFEGLDMDVFMDIDDKDINGDMSLKPKPEDLSDKKVKEDDTPSWPSVYDSLSVMTDDTLGPLSTSTSTSRRIEEDEARNTYETNVVPEMKHVYEDFDCFHRKASIKRRRAKFIKRKYVFGEKDVLKGEAQWMKVVHGFDEPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZD4</accession>
    <name>A0A401GZD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1101950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618431.1">
        <property type="nucleotide sequence ID" value="XM_027762630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZD4"/>
    <dbReference type="GeneID" id="38784435"/>
    <dbReference type="InParanoid" id="A0A401GZD4"/>
    <dbReference type="OrthoDB" id="3357224at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="281" mass="31188" checksum="42D89DBBC842838E" modified="2019-05-08" version="1">MYESTSTPVGLWRAMLLVRSSACKLYALPVGFMLVIESISKKVVDTEFPPHYLSKVSRNSIFKKQHIDVELSCADTALPPLAEDAEVEVCSGYIPPTQRAVQEANEDLDQDGGSKVVDIPHMCLIFPDDGYLEVFSAGREGVRRSCGHEVLGTAACSVTPEPIDYEGLTTQLTQAVKPHISQLIDFAPDKRGTAGLIVDSFIPILHSLHAEFPTFDAMQRLIVGRLATEVRKMRSRLRPLLLNTKMTCCTNMSIIQFEPEPLSLHSQWLRSAWGPSAWTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZF3</accession>
    <name>A0A401GZF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_1102200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618456.1">
        <property type="nucleotide sequence ID" value="XM_027762655.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZF3"/>
    <dbReference type="GeneID" id="38784460"/>
    <dbReference type="InParanoid" id="A0A401GZF3"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="981"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="1444"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1448"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="1624"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="587"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="602"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="747"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
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            <begin position="23"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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        <location>
            <begin position="469"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="492"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="629"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="705"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="803"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE87543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1652" mass="177037" checksum="69846874C9E60DAE" modified="2019-05-08" version="1">MATAVAGSQRSGDLPVAANDGSRPTEADATRHSGHRQKDEVCINFQFRRCRLGRSCHYKHVYLKDPTPHVSVPRPEAGLPPRPTWKSGEICRLFQRGLCLYGDICRHIHVLHQGELPTPSGATPTTDSVPSQREESVLAQHTDSLPSQTPERSPIFSAQPHEHGDVVPPQSTQSVSASVESTDASRSATTVPQDDKNTSVATAVVQKRGLCREYSRRGICLKGKLCKYTHRTEGGATAVRSTDAMAPHFAKNASSSSQMAARAKVDLVSLPSAGTSTPSLKTTPAKDDPVSLFTTGDPAARVASSVPNPSQPATSSSPPTLAVCPATLSSAAKVASSKQGSDASVAPAEQKVVAPSAAPEDPVPPKARVLPSRVNSKKSSAPKAAKAGASTPPEASPSTVPPKTGVVPRVSSGDTSSLTATKHAQSREVPVAASSAAAPTRGSKKTVSASAKAKGKGPEPPADDACAPTSASPIVTSNPTFPAPSKSTSSGAPSTVPPKTAVVPKVSSGDTSSAAATKPAQPKEVLAATSSVEALTPRNKKAASAKAKGKSPVSPAGNASAPTSATPIASSIPLLAASSKKAPSGLPEMKEICRDFTKKGRCKRGVNCPYIHPSQAAGPDPAAVVTENSASTAASSSAAPRQPTKMTSSSKSSNGGEASDESIVSKSKAKLVAEWEEPVDGQDVFERSLDRSKQGRGRKKKTRQKLSAAKASKVASSDNEARTASVEVVTVVADSVEDTITSAQVTANVSVPRPAEQTTHRNTSSRSTLATHSEFVQGSHGSPMEYATVPPTHVRQPSCEPDSSSSDATFYSSLSSLEGSPRSSNSSITQLPVTPREMCIDWFRGNCFRVNCRYSHKGTGCVSKREAVDECRLQDCFSPEHPQDPYLDHLTGALEFSKKLPRRIEKKPAYVVPPNLPQANERPVPLVPPGLGLEALIANGSKLPPRQAPEDAITIPVLDSTKVTYGPGFEIRQLLTGFESQQLFLGQVPCSVTPVAITAALEAYGEVLTVTMPDKSTDCPVMNVRVTFAKPKEAEHAASSLDGAQLFGTVVSARLTTFRSSVGKGVFHDRDVLLEIPVPYRTGFVGYETREQADKAIAMGNGFDMRGNCLSAVFHQRLPQVGTFNVRFIGLPPDAKESDLARFGVNEGVMMDRPNYLSLKRAIDSVIDLLQGFGDLVNVNVLPPPYKRGVARIWAHFSHAGVAENFCQALNGSRLPFIGKGKLFAKHYRTLSFLLPGDVYDVLSNEIVLLRSFTWDNDYGSSISVFDKRPLNGPSAPVQVKLVSVNIPALMRLKAAFEKLLRGEKIVQDGEIVWDGFFNRRVGSLYLENLERINPGVMINRDTRRRTISVFGDAPKRAAVRRMILTKVASLRAQRTHIFPLGGRLIGLFFGSDMAALQRQLGVENVFLDRQNRVLKVRGNEDAQKVAELSVVRARQRHGGERHRLVECPVCFDEVTNPVTLPCGHMWCRSCLSNYLMAAVDNKVFPLTCLGDEAKCSLPIPLETAQDLLSPNDFDTVIHASFLSYVHSRPKEFHYCPTPDCPQVYRKAPRGTVLQCPSCLIRICGNCHVEYHEGAPCSIGDVEDQELFEKWKQGHDVKNCPGCSIPIERAAGCNHMTCARCKTHICWVCLETFSKSNEVYDHMRMIHGGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H011</accession>
    <name>A0A401H011_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1104280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618664.1">
        <property type="nucleotide sequence ID" value="XM_027762863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H011"/>
    <dbReference type="FunCoup" id="A0A401H011">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="38784668"/>
    <dbReference type="InParanoid" id="A0A401H011"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="687"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="443"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="735"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="562"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="923" mass="99050" checksum="A0CA12D5791679E7" modified="2019-05-08" version="1">MRESNFAFPAQNRACVCITSQLYDRRALDTNAPLPLFNSLTHLTYLTSTSPRIREIMTMDGGLERLVRIIHDFCICPPPPENPALFYGLQSPSSHPPKPVPTLIPKSFDRSAQQRFSLALQCVVNIGVRGSEPIRSRVVQAGTLDVVGCILEAWLAGRGFAVGPNVSANGMPRETRERRMARRQAQAEMRSRDHTAELDRALQRQIALDRAIRLERAATGEDVGQDDSMDIDQTSTEDTDTPTDTSTAVTPGGIRGRSGTIIARSTTLHATSSTHRRSRPFMPSASTSADNSRPETETEDDGDVDMDRESSREIDPPSVSVSPSPERRDSSADTGTVRAVPVRSRRLVGIVSDTPSATATVASPDLNTDAHIIINEQGGLGEGVSVEDGVVSLEQNDDLAMGAPPGAPGAIDNPAGRAVTDMHGSAGERTPRARPATLPMMIPIATPTTTPTLRVTGPGEPARTVAPGTGRAHANRGTNTPPTGAAAGPTGAAGQHTHHHPREEFGPYRDEDVLLSLQLLAYLSKYPYVRQAFYKPRPTFHPASLNYPTGDGRVSQAVPGPSGTRSSMTNPSSSSSVSGSSSSVQTPVKEPNSFLRAFASATGRGKEKEKAPASPGASGSTSPVPPQHMTNVFSLVERFTFRHSSSELDSPNTPPSLPPEIQYWAGVIMRNACRKDDSRGGIRQCANMLCGKWETFPREFAKCRRCRKAKYCGKECQSTAWSEGHRFWCSAKDPEEDGDHHHGHGEGSSRSAVTTTAGGTVTGRAERRAERERERHARAVAAEARLAEHLGVRAPGGTVQNPMRTAVSAIGIDPNATLAALNAPPPTPRAPILPPPAGAWAPQPLTARPLRGEEMPPLLSRTGLGLNPPTERGDGEPSREALRHLMHLVEGQHETDRGEGPTVTPFIGQRMEEGAGDDLMIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H061</accession>
    <name>A0A401H061_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1200260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618714.1">
        <property type="nucleotide sequence ID" value="XM_027762913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H061"/>
    <dbReference type="FunCoup" id="A0A401H061">
        <property type="interactions" value="738"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H061"/>
    <dbReference type="GeneID" id="38784718"/>
    <dbReference type="InParanoid" id="A0A401H061"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="235"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="496"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="692" mass="76498" checksum="FC73841A956D892F" modified="2019-05-08" version="1">MSAAQVMSATDAPIVKPKVKTRAKQRYLKAKKERRKQRKGLATVPEKAAEEQSYVLPVGVETDEDSEEHEIDRHASEASDHELERGEAAQKENRPKKRRKLNSSDKGDSGPTTPTSTDRSKTEYREVALTVQDYPRGQSPTPKAILPSFSLPSQPDAPSKSVLALQGIDKALVEAEVIDPAQVMGFSSTANANNGTQLSERTRKRLADLGISELFAVQTAVVPFLLSTDRLKSLYLPYDPPNDVCVSAPTGSGKTLAYVLPIVEILSPRIVIRLRTLVVLPTRDLVIQVRETFEAVSKGRGLKIGTATGQHSFAHEQAQLIADKSPGLQGGSSKVDILICTPGRLMDHLNGSPNFSLQHLRFLVIDEADRLLAQSFQDWLAQVLAATRPPLRQEEPDVSPDLLSEQSVPSTDALSPASLHLLRGVPDICTDTDEKRDSSCQKLLFSATLTRDPAKISALNLHNPRYFIVQSRKESAVPEEASVLDLVMEKFTMPAGLTEHMIVCSSSEKPLTLFHLVHNRGVTNALVFTKSAESTTRLVRLFEYFEAARSSEDQSCCNTVARAYSSDLGATERKSLLERFKKQEIDILICSDLISRGIDISHVSHVVSYDAPVDMRKYVHRVGRTARAGRSGHAWTLVEEQEARYFKSMLKTSDHLDKVKRIRVSDKDVVSLRSSYESALDQLKEAYARSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0E6</accession>
    <name>A0A401H0E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho-GTPase-activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1200850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618773.1">
        <property type="nucleotide sequence ID" value="XM_027762972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0E6"/>
    <dbReference type="FunCoup" id="A0A401H0E6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0E6"/>
    <dbReference type="GeneID" id="38784777"/>
    <dbReference type="InParanoid" id="A0A401H0E6"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="54"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="386" mass="43480" checksum="683A8A2C9C0FE924" modified="2019-05-08" version="1">MTANDSHPPTKASLKSWWNTFTFAQRAKKEAEEKKGENVVFGKPLKESLKYASVQISTANANGELYVWGYIPVVVAKCGLYLKETATEVEGTFRVNGSNKRMRELQAQFESPPRYGKNIDWKKEYYTTHDVASVFRRFLTQMPESVIPHDMYHYFRDALAKNPHNQDEVIATYKRLIRSMPRANQYLLLYVLDLLSVFARKADKNLMTAKNLAVIFRPALIAHPSHELSPPEHQLSQDVLEFLIAHQDWFMLDIPSPPARPAEGPTALGEPVDIMPSSDEEQPGGWKLVNKDASMRRITRRRTTTERAGGDKLQPAAGLSPVLESPPSRTESSAVSVTRSHTLPSKARRGDTLAAHEDERHAAKVLKKHKRASMQTRRPATSDPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0U0</accession>
    <name>A0A401H0U0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618959.1">
        <property type="nucleotide sequence ID" value="XM_027763158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0U0"/>
    <dbReference type="GeneID" id="38784963"/>
    <dbReference type="InParanoid" id="A0A401H0U0"/>
    <dbReference type="OrthoDB" id="3056089at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="530" mass="58005" checksum="3C3CA78F01099714" modified="2019-05-08" version="1">MSSTVQDPDNFDEIIEKEIVPNLPERCLRYFVTTPALHAKAMKKKSAKEKRKASKGRKSAPSVVVSDDSADEENVPLARESEEEDESASTRNKKKQKIDNKEVEVTAYIHVIVPAAASSRPSKSKPTPDTVVKQGPFFFKLHGITLPDFLSSLATATPCRRDAILVNKCQWKFKTPKNAELKPLSDENGFKAMLTSLGQRKKDLVIIISMPEPAKAAVPWETGDDEDDGPQFVHDGGSEATPFQEQKASLDTLMALRLAELREKYPVGNSFLFPGKRIYRNDSSHYWELTDLRLQVWAANIVSGKATVDAPPNSNHFSQSGRLKLPSETNAIAPVASAASSPGFPQVMPSISTATGHGLPQMMPGTSDALMHACLLQLVQQQQQQSNPLSTLSHLLSAALSNPLAPTNPSTVALMNLVNSSTAVNNLSAAINLSSNSTTSAVPTANHNNNKVIPLPRDITVAEFCAKYKISENDCCKLKKLEVILGDRHCEDLEKEIWSGDAGFSKLGWDRFCEKHALFCDEVLCGLWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Z3</accession>
    <name>A0A401H0Z3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618972.1">
        <property type="nucleotide sequence ID" value="XM_027763171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Z3"/>
    <dbReference type="GeneID" id="38784976"/>
    <dbReference type="InParanoid" id="A0A401H0Z3"/>
    <dbReference type="OrthoDB" id="2756970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="437" mass="49880" checksum="88527E75383360F8" modified="2019-05-08" version="1">MAEVHDSQTNLPTRNTSFFNKIRVMVGHAWALREQESPLYMLYSHILTTFCESAGDPLDVDRALGCEPQSSFSAPTGTNFDRRIPDFTVMVAFLHDATVINRFSPSYRSPVLGFWVEVKPLHCDEIWTSDEAYYEAQLGVWSHLEQLNEQGLFAFNHFAGDKFYGMLVLGIYFSVFEYLRPTQSLPPSHSPSQSELRPPPTNSNQARKRPKRKRDDDVTTYLAQTYGEQGMDHAFVKVSRDHPRTLYYCEPILTQGGAVFNPLFRKALRDIMTSRDIDIPFQPSFFTMPTGDYHASEASLEHARQDRDDFIRRQTREEEELKSAVNSDPSIHEEDTSGNYYSSVRPSNTGATRRTRSQSRDDALSEADLEVPFLEDTDDADDNAHSNIEDDMHLGFDLNLDQDIDDNGDDDDDDDDDDDDDDDEAGNVWYSRGRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1C3</accession>
    <name>A0A401H1C3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1300030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619102.1">
        <property type="nucleotide sequence ID" value="XM_027763301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1C3"/>
    <dbReference type="STRING" id="139825.A0A401H1C3"/>
    <dbReference type="GeneID" id="38785106"/>
    <dbReference type="InParanoid" id="A0A401H1C3"/>
    <dbReference type="OrthoDB" id="2802569at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="108" mass="12829" checksum="86D280979357023C" modified="2019-05-08" version="1">MDVDRINISRLSSDEQQKRMKEGLCFLCRKKGHMANDRQFHFQSGSFTRARTVQPGLDTNTITWIKKMREDLAQKKEIPKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1E2</accession>
    <name>A0A401H1E2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1300260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619125.1">
        <property type="nucleotide sequence ID" value="XM_027763324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1E2"/>
    <dbReference type="STRING" id="139825.A0A401H1E2"/>
    <dbReference type="GeneID" id="38785129"/>
    <dbReference type="InParanoid" id="A0A401H1E2"/>
    <dbReference type="OrthoDB" id="2535938at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="72"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="745"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="958" mass="104494" checksum="0E2A063EA06887A6" modified="2019-05-08" version="1">MGIVNKLAANLTNQVRSIAKVTKAVTLGDLSKQINVDAHSSTQGMLGVQARVEGVQGSLAYWSPPPPPKMATNLTDQVRSISEVTKAVANGDLSRSVNVDVQGEMLDLKMTVNQMVARLLTLASEVTRVSLEVGTEGIMGVRHGWPGIRAGRTGHVEGVGGQRQLDGDELDEPVDVRGEMLDLKVTVNGMTESLSVFADKVTRVAKEVGTEGKLGGQAQVMNVGSTWRDFRAQGKEEGRHARGDYVRTRKDVPPHIMAILENVDKASLPPDGVYPTPSSSHIQSPFPMHARPLNSLPLPVPAGSSALPSITEESNEGEVVLGLITIRGAPSPGRDSPPVQPGPRLSPPPQADGPPDVENVAQQDQVDQSERSDNSDGSDDSIEEPLAQAVRRLAGALPLPRDNCPHGGVHPRKPSQRRNHRQGQHGEQDMFEDHDLFAGEGAEENKNDDDEEPGDPAGHDNLPKGSPAKWGISDLPAALNGWPGKTATKFLCDLISGAHGNFQAPSVSIWVESMKDLVEGRSWDAHDGAFRTNALWALVSRVSRAEKVLSGAEFVSMMTKIQLAAKVDSIQKTRNTQVAKGGKMTMAQVYSLISEEPDAPKEKTFSEWVAFGHRFAALAGAGSVYLLMIIAAHGMYSQIGRTKQATIWTMCNCLRWPNPDTLIGQHILGRLIPLASGLSSNIDCRDFVSSDKFFSMFITNTFRSVDRHSESWAPCMTPLTSPLTELEQGITGVDLMVQNILTTASSTCSTRPPSTRAPSPMDDSDDEHHATTMGVCENSDNNDDLFMVDAQSKKFYTPDSSSPNYLVFDTDFRPQAKKNRKAPYPKTDPKERLVWTDEQRHYAGDAWVAKTLENFEEGIQEHYNKDGVKFANSYIYLSRSAFEGKEIRLNSKEGELLAFIASDMSQDMKDTLERGLRSVIFSDGSPEYELQSMDSSASTGQHQFPCIHFSRVPFRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1S6</accession>
    <name>A0A401H1S6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1302000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619298.1">
        <property type="nucleotide sequence ID" value="XM_027763497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1S6"/>
    <dbReference type="STRING" id="139825.A0A401H1S6"/>
    <dbReference type="GeneID" id="38785302"/>
    <dbReference type="InParanoid" id="A0A401H1S6"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="235"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="844" mass="89271" checksum="BE6F00BD4FC2B2AB" modified="2019-05-08" version="1">MATTARQPKPNRKGPPEPANRVRAPAWSSPGPRASPTFSPGATPVRLPNGPQSASPAAFPPLGHANGAPSPAPTRPDKDDRVLAQLSGLTGTTITLSTKTNVRYEGSVLSTNAEGDTTGVTLRDVKDLTVPGAPLRDTLFIAATNIDQWSSGPADAKLTNGDTFKTDTDISQKTGRRERELQAWQPHPDDPSAPSASASTSNSAAPPARTTDDETFGSGSQGASWDQFAVNERLFGVRAQFDEEAYTTRLDRSAPDFKERERQAAKIASEILSSSTSNTHIAEERTQNFVGVAEGANEEDKYGAVVRSANAYVPPGARKGPLPSTNGTAKSPPDIPKVAVNAPDGSAVPAAEKEAGSAQPAADAVPAFRDFVSSEKDRLMKKKQALMKNEMDKRLADLVKFSQNFKLNKPIPDDLVPILAKDEDKQRQIREKSTKDAESSHARAIGATTLTTTASPTVARAVPSAAAAGPATAKVAPELTRQALSKSGTIPPAAQKNATVPSKPGEPPKGRISMVIQSIPPFRGKRVSTAGHSATSSSTQGAARASLNTNVAAQQGGHSPLSPGAANRLNVNASSFRPNVKQFSPPGGSPRLNGTPSSSASPKTKPADSASSVSPVPAPPNPFFGTRTIKKTPPVHIKDDFNPFKHGKVPDAKQVPWTWPYTGKRYMQLFPPPQMQPQPQSPHMQHPGPPQPPPQPTYEEESAAQAATRGYVYAYPPYGYPQQMQMIPGMGPPPPGAYIPGPPAFMQPMAYPMPPPNAMYPSTPMGQMQPYGMPPPPPGAYPPPNGAGPRPSMPPTPIPSHAHPYYHQSPQLQHAVPYQMMMPPPGPHGYDQAQAPPVQMGGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3G1</accession>
    <name>A0A401H3G1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1402980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619803.1">
        <property type="nucleotide sequence ID" value="XM_027764002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3G1"/>
    <dbReference type="FunCoup" id="A0A401H3G1">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3G1"/>
    <dbReference type="GeneID" id="38785807"/>
    <dbReference type="InParanoid" id="A0A401H3G1"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="605"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="958"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1001"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1077"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE88890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1151" mass="128200" checksum="6B7F0A1DFE7AD7DB" modified="2019-05-08" version="1">MAPRKSLFVLESLPELIPPIFDQAQHSMANHRKNCVALHKLQVQAAAVMEPIKQRAAVNLTGEKKFGDVFIDMVSRVLVVKKGPAPAERVFRFISSYIKFLIEKCSQPKEGRRVGSSSNSDDDDTLAVRFVSRLLRWLLQGFVAKDKTVRLRSVSLVAELVVHLGELDEDMYASLRENLIERVRDRESSIRALAIVGLSKLLGGEDPNDLPEDEPSILDVLLDSLCYDTVPEVRRAALLHIPLMPQTLPTLLSRTRDTDPGLRKLLYSTVLFPTDPRTSKGKSTHEDELKLTHPRQLTLAQREQAVRDGLCDREDAVRLVAGRMVGSWFDIMRDGVEGASVFEGLIQFIKLFDVAGPEGADVAVDALKSLCVTRVDILDGVEFSDEFWKNLAPESALVARVFITYCLDHDAEKYLENTGLPVVTALAFYLQEACNELLDAIEELTEARMAAESEGADGTEDEDEDLDRKEDAVLECGFVVGEMLRLAARSDFTDEIGRRKVFAVVREMLTHELLPENLMEPCLDVLKETTAGERELIRIVVEMVHELRDGIGGEDNVLDQISRSNSNASFDTTQSSIRSRSKKRSKEAQEMTSEERAKADAMDMRCLALCIAMLSRVNGSFDENSTLEGVLADLIIPAVRRKELALRERGLVSLGLCCLIAKNMAMSSFQLFLNQVQSAPEELKVKVLQVIFDVLMVYEEEFLRRSGDVAEKIVTFLLQTLEVEESETVQAILCIGISKLVLCGLVIDERVLASLVLAYVSPVTAQNQQLRQCLAYCLPAYCYSSATNQSRMQSVAMVAYDLVVRVHQELGEDEEMITPYQFGLLLIDWTNPQKSVNVEAASTGVTDVHVDLAIDIVKALHDEKRLTEDKKVLCQLLGKLYFPDNPNPLSLLILNTLVANLEEQNLLEDPALEKMIDRFRSRFTKLFSKQLEKLDERLYFKEPRFREMCKDVGIDIEADSASEDEGRDVQEDLVANGPSSPERTAEDAKDSLSYVTVNREASSSPASTAPTRKGKEKAGSVRTARDQNRAVIQPSSEDEEEQKENTAIPEPAFATPKKPRATKRTRSPGQPAFASPVHKRISHRQTPKKLAVDVGDPFDDATNSRKNASGNKKDIKARGKVRPHSPPGDSSEDDGNEIDDAEGSTFNSRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3H6</accession>
    <name>A0A401H3H6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619877.1">
        <property type="nucleotide sequence ID" value="XM_027764076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3H6"/>
    <dbReference type="STRING" id="139825.A0A401H3H6"/>
    <dbReference type="GeneID" id="38785881"/>
    <dbReference type="InParanoid" id="A0A401H3H6"/>
    <dbReference type="OrthoDB" id="2689725at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="85110" checksum="C0822573E7AC7166" modified="2019-05-08" version="1">MPDTSGIDNPFSNGSTAETEQGLGPSVGAEDDMGWQDLPEAMQGDTSFVHAVHDIVGSEWRPRWYKDARTWRQRVQRMDDNWRPLIPDLVEAYIAWCYPFVQPPDAHAPPSPYNFDINVIDFHSLASSVTISRTKDSKSVAQALVLNGYLRMTPLSPSLAISFKTLEILQCLRLFKASFSIEAFAKLLCHYYKLDGEPDRRWDHMFCMDGNNSLKRIAQVGNCSRGDIRVYTDSDYYLPLEFVDKYVDEVPSRIRSSSSGDKDDQSDYDEDFDADEDGAKYPLATVAKALEVLGDKLLAGYDIGCAFEGTIQRSSLGSEWTQRKCHCCVNAFHGYSHNYPCQLTNHPNVIEGMGLEDLETMERIFSGSNNLALITRYASAFRHHVFIDTYFQQWDTKKYTNLSMMLYNNYVQALKIINAETPALEEALQSLQITHKDLAKWSQEEREYFRTLGREQEWDIHAIILASLRQSVHMGIANRWQLTDTQYIATLKYMLTRKYLRALDNLQQLVVQRLFELYKLNLSHTAYRVRTHTAKSLQVRRKVIRNAVKVYNAAANALQPLHPTLDWTKVSHYSFIDEFHILKDTRDDVRKRPWSRPAVPAVRETMKQARRIAQAHVEVERCNIEARRLHTLIRDKECMLDTVLEKLHEEHALIHGAVADFCQRRRNVNARHLACLQQLYALDRFTGELSPGQQEGVTAVGSSPSVVTDFCMHEGDEAEVDEDDDELQGDIGGLVDYMCNLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H488</accession>
    <name>A0A401H488_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1502630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620168.1">
        <property type="nucleotide sequence ID" value="XM_027764367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H488"/>
    <dbReference type="STRING" id="139825.A0A401H488"/>
    <dbReference type="GeneID" id="38786172"/>
    <dbReference type="InParanoid" id="A0A401H488"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="210" mass="24199" checksum="C71E41B88EA5981F" modified="2019-05-08" version="1">MDEEQPLFIVHREPLEPDELIEQQIRERFAAAARKKRSVRDQIIDTFRDVWQEFYLWELGSCQLLIRGLARTSRRAVEPVFEDALELCCGPGVDDMALDEALDLSFSVYDLEQGSRSTVISSVTSIRSHVKPHPKYEACTPSARNLKSDHDADDGTQAVPLRYIQYAGEPGFNEVEYAMLFDHFVWQAFWRDNDGEVLLPVMFQSFHADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4G1</accession>
    <name>A0A401H4G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-alpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1503440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620249.1">
        <property type="nucleotide sequence ID" value="XM_027764448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4G1"/>
    <dbReference type="STRING" id="139825.A0A401H4G1"/>
    <dbReference type="GeneID" id="38786253"/>
    <dbReference type="InParanoid" id="A0A401H4G1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="335"/>
            <end position="341"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="444"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="533" mass="59583" checksum="D1D3532529928790" modified="2019-05-08" version="1">MITHRFSDPDDPLSRAIAPPANETAEECTERLAREAHAQHVSDEIDEELLRDHLVFKKNKGMFKLLLLGQSESGKSTTLKNLQLTFAPQAWQVERTSWRAVIQLNLVRSVNAILDVLAEEMAPPARGTGPYGQTLPTTPYTSLPFSSVSRPLSQTQQTPPQFTPMHALLKLRLAPLRRVEADLKQLLGAATGEVPGSPASTIVSLSQSIPNSPVVLVKAESADAPQQADVFVRSHRSWRDALQEQCKDKSRSPPGGNRREQNRSGDMKRAREMLDDATEILAGCREDMRMLWDDSVVRAMLRRRRLKLEETPGFFLDDIDRISQRGYQPSDDDVLRARLRTVGVQEYSLVFEDAPLATAAIDTGGLVSKEWIIYDVGGTRTSRAAWVPYFEDANAIIFLAPISCFDELLAEDRSVNRLEDSFALWKSVVGSKLLARSVIILFLNKYDLLQAKLGNGVKVNKSMPSFGDRQNTAPVVAKYLYQKFREQYLQLSPEPRTFYGYLTSVVDAKATASTLASVRDGIFRQHLKEADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4I2</accession>
    <name>A0A401H4I2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1503210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620226.1">
        <property type="nucleotide sequence ID" value="XM_027764425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4I2"/>
    <dbReference type="GeneID" id="38786230"/>
    <dbReference type="InParanoid" id="A0A401H4I2"/>
    <dbReference type="OrthoDB" id="5592585at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="437"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="949" mass="108994" checksum="41F132371FAED544" modified="2019-05-08" version="1">MHAKFVLMPVDEFMDDFVPNFQNPLDQQKPDFIDAFENMPGNNKREFDLYKPFVDCVEDAKLCPGHTLRLAQNKADPDDPSRQKVDAALFRTSDNVPEDDRPHWALQHLSIEFKRHRTWDDPFEDKKRKPKRAHKTTKVDDDVGISPKPEQLSHEDPSYMPKSGSLLPGDSLADVMGKGPHDMSRFARLNDVWVLKNSRKYDHFYPSITKMVDTDEDLFQTPPISLRAEDNAKAIFMTAAEADAQRRTAVRGQIISYAKMIFSRQHRCFVFTVLILGDCARIIRWDHAGAIVTHKFHYMTTEHLSEFLWRFSYMTVMQQGYDTSAVPVVSGSADYKLMQKMAVPVDPSDRSKNDYARQSFVKSLNLKDFKEDGPDEWLCWKFTIIPEKRRQKGDVSADRPANPEASSGECREMHFPQGEPKASCATLPVDCEREKFVFLKDAWRVDLDDIEMEGHILATLNREKVENVPTLECHGDVEGRFQQTVTHSYLKLGHPDDLNPIKKHSHYRLVVEEICRPLKDFKNTRELVKIIANCIHAHRLATIRARLTHRDVSAGNLLINETVVKTDGEYETVRTGLLCDWELSKPIEDEDDENQEDIDSEEDLSRESDANNLEIQNVTFKQKKPRQPDRTGTWQFLSALLLDYPWKSVTIPDELEAFFNVLLFHVVRYTNSTVRNVPVFMSQYFDEGTIDSLDVQYTCGSAKRNAIETGTLKEKMKKPITFLDNNGSDHLPLNTIIKELLQLFQAHYSVTLPALLQAQTADQSVHRQKDSDQQLLDRAQTSSEAAADGNTKKRSIQNMLDAQLEAKWQAECTTYTHKSSGELKTPETRLTRKNRAAAEKLKTQDYVYDFLLRMYFQKKWPEHDKIGDRIPPHYSYADYRERGLRFPPPASSSSGSESPSEALRRSRPSKRPRLPVPAPSSTSRGRPPSSYARRKGKQPARPNAIARRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4Z9</accession>
    <name>A0A401H4Z9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1600820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620333.1">
        <property type="nucleotide sequence ID" value="XM_027764532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4Z9"/>
    <dbReference type="STRING" id="139825.A0A401H4Z9"/>
    <dbReference type="GeneID" id="38786337"/>
    <dbReference type="InParanoid" id="A0A401H4Z9"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE89420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="234" mass="26065" checksum="BC95BEFCCBBBDE7B" modified="2019-05-08" version="1">MATLLLLLLHDLHAIAYIAFVNVMAKTSGWDPVLLISQIVSMQSLHYLTLAVLVPPLLTIFAEPSALEYDGGAANVGMVMDWREMAGRLTARTGDDPWSTWNAVWSGGKQLGSTIPHMDDWDGRIDPARGWIIAVCWLVASAVDVYYLYALIRRPRLILDFSLTLIFNHLVLTTYYSKSLPTSLFFWAIMFSSAALMVITAEQLCVKREMAEGLAVAPSNEGEELEMGDLLRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5H9</accession>
    <name>A0A401H5H9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1603150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620564.1">
        <property type="nucleotide sequence ID" value="XM_027764763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5H9"/>
    <dbReference type="GeneID" id="38786568"/>
    <dbReference type="InParanoid" id="A0A401H5H9"/>
    <dbReference type="OrthoDB" id="3265692at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="279" mass="30129" checksum="9207AC0D042C1831" modified="2019-05-08" version="1">MDDPFPPRRRLGKPATAGADSRDHRFFGLSVDSPGASGSSARNTASRIVNSVKRSFSVQRRRDMSPVDRGMYSTPEESIPHTPSRYNFSDAPDTRPTIEQIAMGLHISRTPHLRPVHITSQLSHLHSRHHDGSDDSHVSYGYSPAPRPNGHHRRNSASVLLTPARSSLKKRPSALLVHSAPASAPLTPTTSDLSLSTLTSNGPSTPRSSRSPSVHIIPSRLQLSMSRLLPGKKSSVSRASSPAVTTNSSDDDAGSAELVSRKVVRFSPGVHKDHDVQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H645</accession>
    <name>A0A401H645_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1701890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620776.1">
        <property type="nucleotide sequence ID" value="XM_027764975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H645"/>
    <dbReference type="GeneID" id="38786780"/>
    <dbReference type="InParanoid" id="A0A401H645"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="180" mass="20097" checksum="0B5249C216C3CCB6" modified="2019-05-08" version="1">MPTSAIDDLVHNILAEVVSTIMSTPTSPTLVNGIPSRTQTPFIHASSPSPLIELSHASDEQEFATRLISAICTPVDFTDILVALRNCPQDRQAVVSMQRTLEMVKWMQTARQELIAAEERTSRARTRVDQVWSLMRSTVSRIAQEIWREHGDEDIGHILRYTIDGRPASTPRSSPEPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6E0</accession>
    <name>A0A401H6E0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IRG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1800290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620920.1">
        <property type="nucleotide sequence ID" value="XM_027765119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6E0"/>
    <dbReference type="STRING" id="139825.A0A401H6E0"/>
    <dbReference type="GeneID" id="38786924"/>
    <dbReference type="InParanoid" id="A0A401H6E0"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030385">
        <property type="entry name" value="G_IRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007743">
        <property type="entry name" value="Immunity-related_GTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143">
        <property type="entry name" value="INTERFERON-INDUCIBLE GTPASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14143:SF1">
        <property type="entry name" value="IRG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05049">
        <property type="entry name" value="IIGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51716">
        <property type="entry name" value="G_IRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="IRG-type G" evidence="4">
        <location>
            <begin position="188"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE90007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="455" mass="51216" checksum="426B150CF18529CD" modified="2019-05-08" version="1">MGGTQSTWASSNPWLVRPSPALAILLTVAVLIGQMKKTEDDWMTAEEAKDLEEQWLAEVQKREEARRVEQQAWIMADKMMQELNDKWDIDEDAILAAGKRWEGEGRRLAEEDGRSADVKTRPMDQKSAERKAQPAEGEPPERMPVGEGRSLGEVSTTKAYQAMREERRNDHNESRYAPSRLAERRGDFGGGKESAGIAGSGKSSLINALRGISNSSKGINKGSNLEVAPTGIIETTSIIGRYVDPDPEKPFVWYDIPGAGTLKIPGWQYFNTQGLYIFDCIVILFDNRFTETDIALLQNCARFGIPSFVVGSKSQAKIAAIVKDMQDSESDSDEEDRDEWDADHGSYNRNDRVAREKYIKETNESVLHNLAAAGLPPRRVYLVDKDVLRKVVRESSRKNSSSLFQNIPLIGRKPSREDRVSKDGKLEDQIIDERNLLNDMLRAGYERTAGPWWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6K9</accession>
    <name>A0A401H6K9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1800430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620934.1">
        <property type="nucleotide sequence ID" value="XM_027765133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6K9"/>
    <dbReference type="GeneID" id="38786938"/>
    <dbReference type="InParanoid" id="A0A401H6K9"/>
    <dbReference type="OrthoDB" id="2801804at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="667" mass="76681" checksum="251F364A86607B09" modified="2019-05-08" version="1">MHMKFVKISVNEFMQKFVPAAPSPAPRKSFSRIPGEGALEKNMQAAFAKNVNDKGMCPGYQVAESDSRYDENDSTKQKPDVALYRESELPVDNRPNWNIQRLHFEFKGRCDQDDPFDDKSEDFESVGDKREEHRGQFIQYAEKLFERQQRCFCFTVMMLGRQARLCRWDRSGAVVTEKFDYVKQSYLRDFLWRFAHLSDVDQGYDPTAIPIPKDSAEADLMRKAASPTDENCAHIREYFRNSLDESWTWWRLKVDVHVSAADSTAHEVKGEYLVGKPHFLSHGMAGRGTRGYVAIDCYTKNFVWLKDAWRVDHAGIEKEGDILWRLNDLKIENVPTVLQHGDILRQRTLSQDYWKAPQSNPAMMKPLKSHTHYRLVEKEVCRPMSDFDSGEDLVHLVWDCVQVHKDAMLSADLIHRDISSGNLLINEHEIEENGTKCVVRDGILSDWELSKPLPGKGSVDGPRQPDRTGTWQFLSVHALNNPYRTITIQDELESFFHVLLYFGIRYLRHNFARVGEFIYSYFDDGIPTGDEWICGSEKKAVIKGGVIAQGEDDLKFGFSDDKGDPGRHPLTDIIMDVLSWFNSYYHLTSTFYPNVGGSRAGAGIMQASPRTTKVSKSRRCARRDARRVNKEVTRKGRDPEEDKRLAKYLESHDEMCLILSDALDNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5J3</accession>
    <name>A0A401G5J3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0103110</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608349.1">
        <property type="nucleotide sequence ID" value="XM_027752548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5J3"/>
    <dbReference type="STRING" id="139825.A0A401G5J3"/>
    <dbReference type="GeneID" id="38774353"/>
    <dbReference type="InParanoid" id="A0A401G5J3"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="356"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="462"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="560"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE77436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="695" mass="77859" checksum="0E7AD83BBCF267EC" modified="2019-05-08" version="1">MFPFLLPRVFPTVYCEPDGEVGTSRTVSAFKSVKSVMSVPETELKRWRRTFDANVTTVVDGQKFLNSEQFVNAIAPKGDLTRIGRAQFATLFRVADASKRGLVSWDDFVVFETILKRSDADYYIAFQYFDVDNSGTITYDEFKNVFKANVGSDAIPFDFECDWVKLYLGKKNGTRVLGYNEFTQLMKGLQGERLRQAFKYLDRDQDGFILPEQFKQIILEIAGHKLSDAVIERLPTLTTLSPGGRISYSEVIAFHNVIREMDMVERMIREATSKSKDGRIDQSDFLNHCVSSSRYSLFTPMEASIIFHFAGRGNATQRLALIDFGQLLDPRWKAPLERPEAKTMATTATSVLNEVAHSVYNFSLGGIAGAFGATIVYPIDLVKVRLLARTTRMQNQRSSVVGQLLYKNSFDCIQKVFRNEGSIGFYRGLGPQLIGVAPEKAIKLTVNDFIRARTMDPETGRIKLFWELVAGGSAGGCQVVFTNPLEIVKIRLQVQGEAAKLEHAIPKGATHIIRQLGLLGLYKGASACLLRDIPFSAIYFPVYSHLKKDAFHEGYNGKQLSFLETLTAAAVAGMPAAYLTTPADVVKTRLQVEARSGQTHYKGLTDAFVKIYREEGFKAFFKGGPARIVRSSPQFGFTLVAYEYLHKFFPYPFNGHGREVETALTVQPEDMSKIRARNALKILLDVHGDFGRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5R7</accession>
    <name>A0A401G5R7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0103900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608428.1">
        <property type="nucleotide sequence ID" value="XM_027752627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5R7"/>
    <dbReference type="FunCoup" id="A0A401G5R7">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5R7"/>
    <dbReference type="GeneID" id="38774432"/>
    <dbReference type="InParanoid" id="A0A401G5R7"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018812661" description="Calnexin" evidence="9">
        <location>
            <begin position="21"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE77515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="548" mass="60754" checksum="D02310354A4491DE" modified="2019-05-08" version="1">MRRVALSAALLALAAATVSAVDEPKPVLKPTDIRAPFIEQFSEDWAERWTASEATKKTSVGGETFSYVGKWAVEEPIISVVEGDNGLVAKTKAAHHAISAPFSDPIDFSEKPLVVQYEVKYQKGGNCGGGYLKLLEDGFQTEGKEFSDKTPWTIMFGPDLTCPGTKIHFIFRHKNPITGEYEEKHLKVPPKPTIEKLTNLYTLVLNPDNTFDVLFNGESKASGNLLEDFNPPVNPPKEIDDPEDSKPADWVDQKKIADPEATKPDDWDEDEAYEIPDEDAGKPEGWLDDEPETIPDPDSEKPEEWDDEEDGDWIAPTVRNPKCDEAPGCGEWKRPTKANPAYKGKWYAPLIDNPAYIGEWAPRKIPNPAYFEDLSPVKNLNKIGGVGIELWTMTEDILFDHVYIGHSVDDAKALAAETFDIKHPLEVEQSKAKKVVDADEEEETISFQEDPIEFLRAKIFKFVELAKLDPLLAFKTQPETGAAFALAVVTLFGMLGMMFGFIGASQATITKSSKKTDAPTPDDKQKTETTPVVPAGGEKVDTTLKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6E7</accession>
    <name>A0A401G6E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0106220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608653.1">
        <property type="nucleotide sequence ID" value="XM_027752852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6E7"/>
    <dbReference type="GeneID" id="38774657"/>
    <dbReference type="InParanoid" id="A0A401G6E7"/>
    <dbReference type="OrthoDB" id="2911807at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="398" mass="44117" checksum="B2AC4F1FDAC60C3B" modified="2019-05-08" version="1">MNAPAGAQAACLDIDSAFRNLPIKPAHKPFLVIQCDPGDFYVDHVLPFGVSSGTGVQGEPMDAIIDILDANDIGPSHKWVDDLITFRFPTNQCSISGAYEYALGLADIFRITDPLGVPWHRTKYSDYASCAIYSGFLWDLGQRSVALPEEKRAKYLAKLTAFIATVERGRVLQRDAMSINGTLSHITFVYPHGRAFLTNLCSFIAAFTNRYAPRFAPRSVLSDMKWWLHILNVPNVTRSLTPRGPLQDLGIWVDASSSWGIGIIISGEWSAWRWRGEADAWKGDGRDIGWAEMVAVELAVRTIEALGHRDATILVRGDNKGVEGAFARGRSRNHQVNTSIRRTEVIAMSLNILFIIRYVNTKDNLADSVSRGDPNPSMSHRQLSFQLPAELAAFLTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6F1</accession>
    <name>A0A401G6F1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pheromone-regulated membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0106280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608659.1">
        <property type="nucleotide sequence ID" value="XM_027752858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6F1"/>
    <dbReference type="FunCoup" id="A0A401G6F1">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6F1"/>
    <dbReference type="GeneID" id="38774663"/>
    <dbReference type="InParanoid" id="A0A401G6F1"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="580"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="211"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE77746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="679" mass="73791" checksum="611E82586B4BCC28" modified="2019-05-08" version="1">MASRQSVVESGNDPSPRRFSYPRESPPEPSAKPYRDHPTPHPHRFSDGASYFSPKDPDPRSRRASEHIPPKSNVGETLSVQDSRPAFPSWSSSFESSILPSDLRQERTLSSLEAGQNKPRRGGGVVASLIQYGLARATGNGECKFDGEKQDNALSRSTSYASADGDLEKASSGRPAARSKQSYRDKCLLRRGRRQAEIVRNVESYVKRQKFILKLAKALLSFGAPSHRIESQLHSASGILKVNAAFVHFPNLIIVSFLDSDTRTSETHFVRAGGRVALTALHKVHLIYRDVLHDDISASEGTEQLKKILQARPLYNIYVRCVFAFICSSIICTLSFGGSVVDMFISGASASLLQYLGLNAASKSSIYANVYEISVSIIVSFLARVLGTLPGNIFCYSAISSAGVVLILPGFTILISALELTSKNIMCGSVRMVYAIIYTLFLGFGLTIGSDFYLVIDRDARRNLAVSSMLGSETYHGHIIANNDSLSLASLGGTFSFTDVAEAATHVVKGCYRDPSWPWYRQAFPWWTMLFLVPFYSICSSLANLQTIRSVQLPVMVLFSCAAYAANKGASYLISGRGDIVSAFGALVIGLCGNLYSRVVGGTAFTSMVTGVLFLVPSAIGNGGGLIQNYDSSSAQYSNSFDLGIRMIEVAIGVTIGLFVAQIMVYTLGRRKNAAHFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6F8</accession>
    <name>A0A401G6F8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0106340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608665.1">
        <property type="nucleotide sequence ID" value="XM_027752864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6F8"/>
    <dbReference type="STRING" id="139825.A0A401G6F8"/>
    <dbReference type="GeneID" id="38774669"/>
    <dbReference type="InParanoid" id="A0A401G6F8"/>
    <dbReference type="OrthoDB" id="5594057at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02509">
        <property type="entry name" value="GDP-M1P_Guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049577">
        <property type="entry name" value="GMPP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054566">
        <property type="entry name" value="ManC/GMP-like_b-helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051161">
        <property type="entry name" value="Mannose-6P_isomerase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46390:SF1">
        <property type="entry name" value="MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22640">
        <property type="entry name" value="ManC_GMP_beta-helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159283">
        <property type="entry name" value="Guanosine diphospho-D-mannose pyrophosphorylase/mannose-6-phosphate isomerase linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="129"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP isomerase/GMP-like beta-helix" evidence="3">
        <location>
            <begin position="435"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="489" mass="52655" checksum="42D5F4F16F3DF003" modified="2019-05-08" version="1">MSFPTPSSLPANGLPVETMFKHIMDAVQKSHAEISELRSEYHELRQANATLERLVRESTQHNGSRLGTPGFQTPAPSSPLLRARSPFLTPGSIPALAVPPSFHIPSPLSDNALTAFPFGIRDIPGFYVVIPAGGAGTRLWPLSREGHPKFLLDLTLKGRSLIQATWDRLLPLSSAARTTIVAGPAHVRSITEQLPDLLPHNLLCEPSAKDSMAAIGLAAAVLSKRDPDAIIGSFAADHMISGDDAFLAAVAEAVEVAKKDYLVTIGIAPSHPSTGFGYVRLGEKLGLSDAPNAHLVSSFKEKPDARTAAAYIKTGNYRWNAGMFVTKAVFLLQLLKEYKPELHDGLQKIAACWDDESVRQGVLDEVWPRLEKIAIDNAVAEPAALDRRVAVVPATFGWDDVGDFSSLAELLPADTNQPRVLGDSNLVLTEQAAGGIVVPASGRLVSLLGVDDLVIVDMPDTLLVTTRARSQEVKRLVKKCRDAGWKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6U9</accession>
    <name>A0A401G6U9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial inner membrane protease subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0107590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608790.1">
        <property type="nucleotide sequence ID" value="XM_027752989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6U9"/>
    <dbReference type="FunCoup" id="A0A401G6U9">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6U9"/>
    <dbReference type="GeneID" id="38774794"/>
    <dbReference type="InParanoid" id="A0A401G6U9"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019227547" evidence="8">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="26"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="9">
        <location>
            <begin position="97"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="160" mass="17769" checksum="9552976300A7AF4C" modified="2019-05-08" version="1">MAKSTSLTILHAFNVWAAIHLFAENVGWIYMVDGPSMVPTMGVSGEMVIENRMITPKHLSRGDLVTFTSPIDPGRVVCKRVIGLPGDVICVDPTGEYAPSTEHVVIPKNHLWLSGDNAPMSRDSRLYGPVPMPLVKGKLFARVYPFRDATIFRSNFHYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7S1</accession>
    <name>A0A401G7S1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0110990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609129.1">
        <property type="nucleotide sequence ID" value="XM_027753328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7S1"/>
    <dbReference type="GeneID" id="38775133"/>
    <dbReference type="InParanoid" id="A0A401G7S1"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45621" checksum="A463C6A8E286BDBF" modified="2019-05-08" version="1">MSGNLSFLGIPAELRLVVYELYLSEHQHVSNRRQPSNHHIRLLYICKQVFDEAVSIIGRYVSLQHERQINAFILHATESQAAQIHLADVANDGRVSGPTNASVDADQPLVPLSNLHLALRRMTSLTCLRVFQCRQGIPINIQKINARLAIRFEHAMYPSGYPHHLTAYELFLDPETRVTLFEVVLPQFIEVLRVTGECHLPAAVCMPALRHLMLYGITGNHFDQHTVEESLSGCRLHSFIYGLGHRLGFEIRNRHLESLASVAGAHLRKLVLLGCSRLTSTVIAACLENMPKLEHFALSLVTVDELRTNFVLSLPPTISVFKLQLTNAWYAIPLLSDERGLCNALEDVLLRRPIAPQHVCVCLRNSLMIEGDRQDRWKELARNRCFQLDFGLWQGEDLEDLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G854</accession>
    <name>A0A401G854_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0112400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609268.1">
        <property type="nucleotide sequence ID" value="XM_027753467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G854"/>
    <dbReference type="STRING" id="139825.A0A401G854"/>
    <dbReference type="GeneID" id="38775272"/>
    <dbReference type="InParanoid" id="A0A401G854"/>
    <dbReference type="OrthoDB" id="3257768at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="233" mass="26237" checksum="148AD67A695F008C" modified="2019-05-08" version="1">MKEMGPGAWWETIDNVCGFHNWRKMVELENMLLHQMLEVIPEAIAHHEDFCKFTSGLLAQCPADVSAWRTMLEEWEVDHSKPDPYVLPKSTVTLAEVHLKLAKEEQARVQAMQDAQLDVSPGTFLLGDHHSADSDTALHEGLRAFAMEHAAMERNLAANFDSKWTVVWQRMQTILRDLNTAVQVLDSSLDAASEQDNDIESEAVDLDAEIDCNVELDVDLGLDEDLENDVDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8C9</accession>
    <name>A0A401G8C9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="10">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PIF1</name>
        <name evidence="13" type="ORF">SCP_0113240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8C9"/>
    <dbReference type="STRING" id="139825.A0A401G8C9"/>
    <dbReference type="InParanoid" id="A0A401G8C9"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 10 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="139"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="10">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="147"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE78436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="682" mass="75763" checksum="E6AD60F6A81FB315" modified="2019-05-08" version="1">MPKANKMKYYAVRNGREGAKVYTTWEEAKENVSRYPGAVHKSFTSQTEAQRWLNVAAPLQRTYLEGPPKDWTPPPPQDPAAGPSRRSKSFNGQPNPGTAMNIPADSFLGNLPPALPQQPPEPKVALSSEQRAVLDMVQQGRSVFFTGSAGTGKSVLLREIIKFCTEHSGKRPAVTAATGIASVNIGGCTLHSWAGIGLGKEDAKVLVGKLLGKHKQLLKKDKEKGRQAEDDMDWYDETGTEKNSWSVNRWREVKTLIIDEISMIDGNLFDKLEYIARILRRNKAPFGGIQLVLSGDFCQLPPVPDRMNGVSKDIRFAFDAHSWEDCVGRPVILTHVFRQKDQAFVDMLNEMRFGRLSPKTITEFRKLSRDVEYDDGIEPTDLFPTRREVDNANDYRLANLSDPRHEYKARDVPGYDDNNAPISEKKMEAMLDRLIAPKAVTLKVIFHPFAPNIQLTYIRKQVGAQVMLIKNLIQGELVNGSVGRVVAFSKVKDAINGGALVAHDQGVSGGGSSLPIPGGSMMAGGSTSSGDRNKDQGKIPEHILLSNDVWPVVKFQKGLMVVCIPTAFEQTNAIGTMEAMREQVPLILAWALSIHKSQGQTLERVRVDLGRIFEKGQAYVALSRATSMQALQVLKFDPGKVMAHPRVLEWTRQVTAKRGVIEDDMEFETNLDDDLEFWADYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G907</accession>
    <name>A0A401G907_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0115120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609536.1">
        <property type="nucleotide sequence ID" value="XM_027753735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G907"/>
    <dbReference type="GeneID" id="38775540"/>
    <dbReference type="InParanoid" id="A0A401G907"/>
    <dbReference type="OrthoDB" id="2802569at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="221" mass="25120" checksum="AAA1EE6CE6B1D03D" modified="2019-05-08" version="1">MHIRFAKENDFIKWELPKPIKVVNANDTPNQMGTITHCTWKMMKIGGRKTLTRFLLTGIGKENILLGMLWLKHLNLMINWETGDFWFGKDAKWPPKPTVEDVPDEEVSIFKEDDLPELITTETSPTSFGHSESIREIMADNTERGELPAVRNDTEPDDPPLEPSMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLMNEETGTAVFTIRRGPTIGRMTHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G960</accession>
    <name>A0A401G960_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0115920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609614.1">
        <property type="nucleotide sequence ID" value="XM_027753813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G960"/>
    <dbReference type="STRING" id="139825.A0A401G960"/>
    <dbReference type="GeneID" id="38775618"/>
    <dbReference type="InParanoid" id="A0A401G960"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="484" mass="52364" checksum="FB6D68E256603BE6" modified="2019-05-08" version="1">MSYFNLAPRTYVSGADSPGSSVFDLPTQPERKASNGSSSKTAAQVDVPQNGSQSFLVISGGTGCNSICAAFGNASYVLPVSDDGGSSSEIIRVLGGPSIGDIRSRLVRLIPSAPPSSPLDSIRTLLAYRLPADRTEREARDEWRDIVEGRSHLWSGIPNDRKELIRGFLVHFENEVLKRAHKNFSFVNGSIGNYFLSAAQEFFRSLPSAIFLFSSITNSQANILPVIVTNHTVTIAAELENGRRLVGQCEISHPVHGAPTISVAPDDFDVDPDAVSSMDALDGMISPPQNVMFQSRAKGAYEPLDARISRLYYINAYGNEIHPSPNSDYITNLSLTDVLVYSCGSLWTSIIPCLALKGVANAIARSRSLRAKILLLNSRNDRETHGYTAVDYINTIVRTLNTPYHKHSYGGLGNADTTYPASAFITHLLYLRGAAIAVDVLEITRLGVKCVEVDAPADGTTGVPQFDATCVRRAIDRVLAEAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9P6</accession>
    <name>A0A401G9P6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609782.1">
        <property type="nucleotide sequence ID" value="XM_027753981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9P6"/>
    <dbReference type="GeneID" id="38775786"/>
    <dbReference type="InParanoid" id="A0A401G9P6"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="31719" checksum="5360CF341C3083DB" modified="2019-05-08" version="1">MVMEVKEDQNGAAQHAISCKSSALRSHRLEPITKLEGNEFLKAWVDCYRSHYRLWTQGVVCDDIGLQNLMYDVHTKRGVLTDLDISRGKRRPGVFRPLTYHDKNSDKRRAYRHYCNGMMSFIWILCYALLKRCHDVRYRALLDGWSPRHHDHRRYQKAQFTNLVLIDMRSGTTQSAEQHSIDGRIWRVVRILVLWLSVRKGMFALEEFGYSPWDHDPKKIFDELEKVIGATWTSGSFVPLHGPAPLKPRFRRELNSFLPPCWKIRRAGHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9T2</accession>
    <name>A0A401G9T2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0201310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609847.1">
        <property type="nucleotide sequence ID" value="XM_027754046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9T2"/>
    <dbReference type="STRING" id="139825.A0A401G9T2"/>
    <dbReference type="GeneID" id="38775851"/>
    <dbReference type="InParanoid" id="A0A401G9T2"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-galactosidase" evidence="9">
        <location>
            <begin position="425"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1035" mass="111935" checksum="0C4577730961BB9E" modified="2019-05-08" version="1">MLWHHRSSWAFPAFLSLFIVFFTWPFTLRTAASTRAEYANLAAASPTLKSDNLTDVVQWDNYSLFVYDQRIFLHSGEMATFRLPIPDLWLDIFQKMVAAGLNAVSIYIHWGLTNPAPGVLDFNDWRALQPFFDAAKLAGLWIVLRPGPYINAETTAGGIPHWVTSLVAGQLRTNASDYEAAWQPYIARIAENVIPNQVSSGGPILAVQVDNEYYQDAVTGEYFAELEAAYRSAGVVIPLTYNDPGEGSNFINGTGAVNIYGLDSYPQGFDCSHPEQWASVVTNYHQYHEEVDPGEPWYMPEFQGAVHNVFMSSSWQLIFDMTGGAFDPWGGPGYNNCEILTGADFMDVFYKQNWASNVKLISYYTVYGGTSWGGLPEPSVYSSYDYGASIRESRLLSDKYDEIKRQGIFIRSSPSFRKTDWVGDTSTTIPGVTVNGSGAYVTLLYNYDTGTGFYIARQADSTSTTNINFTLTVPTSAGTLTIPSTSGAIALDGRQSKVIVTDYAFGAQSSVLYSTASIFYAGTIGARDVLFLYGDATQSHEVALVLNGSSAQASDVSYSNAGGAGGITTVTFLPGITGLVTVWDSATQLILYADPITTATFWAPAIPTAGASTDFPNYFQFGTNETVLIGGPYLVRNASIADGELALRGDLNASIPLTVVAPPEVTRVSWNGVPVELEFASADGGAQGGVLAGSLQMSTALAQVTVPALTGWRYNNSLPEVLSNYSDAEWVVANHTTTNIPAMLYGDGRVLYGCDYGYCENAVLWRGHFEGTGSETSVNLTINGGTAFGATVYLNDVFLNSTYDISAEQTTELYTFPPGSVQVGQDNVITVVQDSSGNDEDANEKSPRGIPGFQLNGGNFTVWKVQGKLGGYMNYPDKVRGVLNEGGFYGEREGWHLPGFDTSSWTTRELTEGLPGGGPGIGFFVTTFDLAVPANSDVLMSFQYDTSSQPYRAQLYVNGWYYGKRVANFGPQTNFPVSQGILNYSGTNTVAVALWSMENTPVSPTLALQVNTVIEGGVGAIALNNPGWTPRPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Y3</accession>
    <name>A0A401G9Y3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0201720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609888.1">
        <property type="nucleotide sequence ID" value="XM_027754087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Y3"/>
    <dbReference type="GeneID" id="38775892"/>
    <dbReference type="InParanoid" id="A0A401G9Y3"/>
    <dbReference type="OrthoDB" id="3058835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="12031" checksum="49F5A9DF93F234C6" modified="2019-05-08" version="1">MDPQAQLTALAAGLPEDTYHALEAILRDLDHRVTHTQAPALSADDIRIALEHGFANTQFNLPPAHFTLPPAPPPPPVSVHPSQFKVDLAHFHGKDSDDLGAWLTLIEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA03</accession>
    <name>A0A401GA03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome regulatory subunit rpn10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0202130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609929.1">
        <property type="nucleotide sequence ID" value="XM_027754128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA03"/>
    <dbReference type="FunCoup" id="A0A401GA03">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA03"/>
    <dbReference type="GeneID" id="38775933"/>
    <dbReference type="InParanoid" id="A0A401GA03"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="246"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="340" mass="35973" checksum="5D1653BF8B3A08CE" modified="2019-05-08" version="1">MPLEATLMIIDNSEYMRNGDYQPTRFDAQADAVNTLFQTKIDSNPENTVGIMTMAGKGPEVLVTHSKDLGQILQAIHTSRDKISGTADITTAIAVAQLALKHRQNKNLRQRIVVFVGSPLNGQSADERAMVRLAKKLKKNNVAVDFVAFGDGIEEGEGGILKTFIENITSSDNSHLVSVPPGPHLLSDILLTSPVLAGDRGIPEEAMGMGDASGSGAVGAGGFEFGVDPSLDPELAMALRMSMEEEQARQAAAAQASGAAGAAADAPTSGPSTAPTEPMDDEEEAMLKQALAMSEAQDVEMGEHPVHEEDEEMSEEEAIARAIEMSMKGEGGKSNDNNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAE2</accession>
    <name>A0A401GAE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0203180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610034.1">
        <property type="nucleotide sequence ID" value="XM_027754233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAE2"/>
    <dbReference type="STRING" id="139825.A0A401GAE2"/>
    <dbReference type="GeneID" id="38776038"/>
    <dbReference type="InParanoid" id="A0A401GAE2"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="493" mass="54255" checksum="DBE51B44847C7C06" modified="2019-05-08" version="1">MLALAPSHLPCQPPSVVHPTPLRPHTSAATSETYTLPGHRPPPRKLQSAFALPTYAAASSSHSSVPPTPTSQDSPGPSARRPVAPPTPPSQPGPPSFRCEQLEHEEEDPQTPPASDSEDNDDEVVPPESSDIDVNDYDSETLLGMLASTLSRIAKLNSVPPANTYMSTPLRPPHSSDSEHHGPIWRTLTTASRESLARSPSLTFHARQIPTIALDSYLQRIQKYCPASNEVFISLLVYLDRMTRLARDACGEIIPIDFYNIHRLIIAGITVASKFFSDVFYTNSRYAKVGGLPLAELNVLELQFLLLNDFHLTISPEEMQYYTKMVDLQSKIGDDISLTPFLPSTLSPMIPDTYIPVGPTEYFAAVSAYFAHQQALAHPQRAFHRLNGQSELPLFCPAMDYHLSKRQSMASLDTTSETEPEVETDVECYTDDEPTIRAPHSSSESSSETTSLHSSTSGDTDSIFTDDEDRSSDEPDVRLFDGRHSRQGGTTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAL0</accession>
    <name>A0A401GAL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein rds1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0203880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610104.1">
        <property type="nucleotide sequence ID" value="XM_027754303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAL0"/>
    <dbReference type="STRING" id="139825.A0A401GAL0"/>
    <dbReference type="GeneID" id="38776108"/>
    <dbReference type="InParanoid" id="A0A401GAL0"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019127295" description="Protein rds1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="56052" checksum="F9595B279176E3DF" modified="2019-05-08" version="1">MRAFVSILAIATPLLVFGAPVKRQAGNSTDVLVLQFADVLENFENQFYTQALGQFQQADFVAAGFSNVQIPIQQFEAIQSDEAAHVTALESALQALGASPISGCQFNFSSALTNVSTMAATARVVENLGVAAYLGAANMISDPTLLTAAASIMTVEARHQTILNLMNGATALPQAFDIAFTPSEVLAIASQFISGCEIGIPANPTLVVTNTSPPLPGTTLSFSSSALNGSTDGLFCQMLVGGLPVSVSQNFSSCVVPDTVNGPAAVFITSDDQPIDSNVRDQNTNTVVAGPAMIFINANVDALGELVLSGAAAANATTKNATTNATLSAGSSTRTISPSQASAIVSSALAQGASVSAVAGAVPSSMNSAPVVAMPGVSGASSNATSSADSSTRTISPSQASAIVSSALAQGASVSAVVGAVPSSVSSAPAVVMPDVNATSSEDSSTRTISPSQASAIVSSALAHGAPVSATAGAVPSSLNSAPAAATPGVSSASAAATPGVNSNSAGATSDVSSGPASALSVPSASASSSAAPAVATDSTAISGGTDVVAFLGGPNLYTGPAADGSVTVNGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAP5</accession>
    <name>A0A401GAP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0204350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610151.1">
        <property type="nucleotide sequence ID" value="XM_027754350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAP5"/>
    <dbReference type="STRING" id="139825.A0A401GAP5"/>
    <dbReference type="GeneID" id="38776155"/>
    <dbReference type="InParanoid" id="A0A401GAP5"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="100"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="220" mass="25347" checksum="41D24AF4DF6031F9" modified="2019-05-08" version="1">MSKPLLLYTGPTPNGHKVSIFLEELKQTYEGPDYDVFSINISTNVQKEPWFIKLNPNGRIPVLVDRSRKDFVVFETAAILLYLQQHYDKENKFGFDKDKDADNYSEMLQWIFFAHGGVGPMQGQSNHFQRYAPEVVPYAKKRYLDETKRLYGVLEIRLTDRDWLAGPGRGTYSIADINVLAWIRFHQIAGVESLDEWPHVKGWLAKALERPGFQAGIKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAV6</accession>
    <name>A0A401GAV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0205020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610217.1">
        <property type="nucleotide sequence ID" value="XM_027754416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAV6"/>
    <dbReference type="GeneID" id="38776221"/>
    <dbReference type="InParanoid" id="A0A401GAV6"/>
    <dbReference type="OrthoDB" id="5410040at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="51" mass="5691" checksum="B821349C7A88C6F7" modified="2019-05-08" version="1">MVTVSASTVLPCPAGKNRFADGDVGEDVPRRRVAVVEKRPRRWIEETNPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAZ3</accession>
    <name>A0A401GAZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610248.1">
        <property type="nucleotide sequence ID" value="XM_027754447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAZ3"/>
    <dbReference type="STRING" id="139825.A0A401GAZ3"/>
    <dbReference type="GeneID" id="38776252"/>
    <dbReference type="InParanoid" id="A0A401GAZ3"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="66732" checksum="89D9DED1970F0730" modified="2019-05-08" version="1">MASAQTPWTGPFQLPTLDRLKAEVPASVVPLDIARRWLGDFTNALRSQPVLLGPLFLEDAFWRDLLALSWDFRSIQSSANIAKYLDAHISSSGLRSLTLCEDSLWAPVLRTPYPDLALLQLSFRFETAAGAGTGTCRLVPIESGEWKAYTIFTCLETLHGFPERIGSLRDRDMYQASWEDTRRAGLEFADGRPAVVIIGAGHCGLELAARLKAIGVRTLVVEKSPRVGDNWRNRYKSLRLHDTVWYDHLPYMPFPSTWPVYAPGAKLGNWLESYAEALDLDVWTSSRVQSANWNAEKKTWALTVRRGEAIRQLQANHLVFATGLNGSIPYSPTIPEQERFKGQVLHSSQFTSPESFRGKKVVVVGACSSAHDISRDCMNYGIDVTMFQRSSTCMVSAEAIGQLVLGMYGEGTSLEYADHVGAATPFAVTRQLHQRAFPHFAATIDKELLDGLARVGFRTNLGPDNAGIMPMVQTRAGGYYLDTGASQEIIDGKIKLKSGGTIAAFTESALRFSDGSELPADIVIFATGFSNPRDVVKDVCSPEVYAKVKPVWGLDDEGELNSVWRGSGHEGLWFALGNLSTARFWTRLLALQIKAYEEGLLKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBP3</accession>
    <name>A0A401GBP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0207790</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610492.1">
        <property type="nucleotide sequence ID" value="XM_027754691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBP3"/>
    <dbReference type="STRING" id="139825.A0A401GBP3"/>
    <dbReference type="GeneID" id="38776496"/>
    <dbReference type="InParanoid" id="A0A401GBP3"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="94"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="296" mass="32785" checksum="E1E735ED81E7AA19" modified="2019-05-08" version="1">MTSTERFSVAWPTFRYYVGTAYRRYNKLHIYGKLFIWGTICVWVSLATIFVVIGPDRIGQAFYDLAHKINQLPFGWLIIAGLLVIESFPPVMGHTTTVTLCGYAYGMKGFYIAAGGSLAGACFAFAVLRLLFRERLRRWSASNQKWIALETVVGAKGLPLITLVRASPFPPWGWAHAMFASVDTVALWQFFLASFVLFPKFALFVLIGSRLAALSDGDQRSHMDTSTKILNVAISVGGILLSTTAGWIIYRAMQAEVRRLQEMTPEVDELSTEGTDDAAEEAPLLGEYAPSLSSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC16</accession>
    <name>A0A401GC16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0208970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610610.1">
        <property type="nucleotide sequence ID" value="XM_027754809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC16"/>
    <dbReference type="STRING" id="139825.A0A401GC16"/>
    <dbReference type="GeneID" id="38776614"/>
    <dbReference type="InParanoid" id="A0A401GC16"/>
    <dbReference type="OrthoDB" id="3246510at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="874"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="430"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="569"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118229" checksum="2E9196F0BF25593C" modified="2019-05-08" version="1">MAKADDQNHSSQFKFKRQILRSDAPAASPRPSLQSPIFSTTGKQLGDSLRGTQVAPYGASLPPSANSQRRLVVHQRMQSPPDETKFQLPCATRSGDLALPEAVKPQASSLGDPQMAQSPPMSQNNARLFLGKHLSASPAQRTVGNNLSNRFDTGFNNPQDDNASYMPNRASSSLSYTVPSVTPKPIPSSMHNNFMPSSHSRSASVVSSTLGRQDEDISSIMMRGATDLRNTKYEVEEQRREILFLQDQLETAKSEKDEALKRLQAVKDAAKHSLESSSKSLNDLQSTLTDLKTKSDDSFAVVSAVRKSLPDVQELRVSISEAIKNIEPLLGEDGHLSRTSETMALVSNLELECTKSQQVSDLLRDRLQSVGSELIDAKGRVIELEAAQAANREALRASACSVSTTTQQVTELAECLKKQQGEMYEVLSTAADAEAKLAASNQRMEQLENLVAEKNVELQALHEVQQENARLLNALQDRDARLSSLGDIQQELSTVQSTLNERHTKVSALEACALLREEDISHLKSSSAQVQAQLEEAKAVGQSLREDLRACELREQAALEERERHSSDGRALQVRLEALESQLEQARRELEARSEKLHQANSRCQVLEERFDDQSVTMKLTREANGDLQERLVAAEAKFARDFETAVAKLNCDIVSLDQQKLHLQSKIDDLSEHLKRQEEASLALKTEHAGQLKHQDEMFRMRLEAEEKRAGRAERELDTSQVLTESLREKLSGHADEIHCLREELKKAKLPSPAHEAELKTLRSEIDALQTAKEKLLERAKTIDIRYRKGDLTDEEKVFLNGLMQTWKDIHEKGLVAKGNELRRRDNVIKDLRSKIYMLESSLAKHLQLQENAKVVENRSMIDPTAWMSASALSSSPAATGPQAPDRDAPSTNVDSTTTARPTPAPVRPQPIRTNAVPQAAPTRVTPTRFLVANAKVISTAPKISAAAFVSPVPTSPEITIPKPIFSRLATDSSDEILDFEDGATHRLSPAVKLGKRDNMSSPPKDTEARSIPRPSKRLRATTRKPEERVNEEQVKSTSKLKKELMRNSSTLFTVDAPLNQVKRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC53</accession>
    <name>A0A401GC53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0209260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610638.1">
        <property type="nucleotide sequence ID" value="XM_027754837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC53"/>
    <dbReference type="GeneID" id="38776642"/>
    <dbReference type="InParanoid" id="A0A401GC53"/>
    <dbReference type="OrthoDB" id="2685617at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24324" checksum="5A05FAED0322D882" modified="2019-05-08" version="1">MATTTESYQLKLPFILASVSPDLAALHALRARLLRPTDAALNALHCPRCGVLLVDGCGETRLTRSYRNREDPGNNKNAASFRRLLRRSCKRCGYRGAAHVESDSPLSFPPPRRQGHKGVAEKKARHDSEQAPNTVNPYSTSRERCVAPLTVAPSPVPITDESVHAVLPSALSPSTSSVRPKRRSKNFDLQEMLVRSRKRQEEAKELRSHQLSTLLQELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC92</accession>
    <name>A0A401GC92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pre-mRNA-splicing factor cwf14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0209810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610693.1">
        <property type="nucleotide sequence ID" value="XM_027754892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC92"/>
    <dbReference type="FunCoup" id="A0A401GC92">
        <property type="interactions" value="561"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC92"/>
    <dbReference type="GeneID" id="38776697"/>
    <dbReference type="InParanoid" id="A0A401GC92"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018230">
        <property type="entry name" value="BUD31/G10-rel_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00998">
        <property type="entry name" value="G10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="148" mass="17281" checksum="CB63EF4B83878AFF" modified="2019-05-08" version="1">MPKIRTTRTKQPPEGFEEIEGILDDYAKKMRDAENETHEGKRKTESLWPIMRISHTRSRYIYELYYKREAISKELYDWLLKEGYADANLIAKWKKPGYEKLCCIRCIQTRDMNYQGSTCICRVPKAQLRAGTVVECVHCGCRGCSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCE3</accession>
    <name>A0A401GCE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0209940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610706.1">
        <property type="nucleotide sequence ID" value="XM_027754905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCE3"/>
    <dbReference type="STRING" id="139825.A0A401GCE3"/>
    <dbReference type="GeneID" id="38776710"/>
    <dbReference type="InParanoid" id="A0A401GCE3"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000001">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="410"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="656" mass="70856" checksum="1F3A3502D7C7AC8E" modified="2019-05-08" version="1">MSESPSPIRVAILTVSDTAAADPVADKSGPTIKDILARRGYECILELIVPDDESRIREIVREWCDQGADWVITAGGTGFGVRDRTPEAIRPLLEREAPGLVHVLLSSSLRHTPLAALSRPVAGTVKNTLVVTLPGSVKAVRENLEVLLANGLVEHAVDLIKGGTGNRLHTELTSTSSSEERMLHQIHHHHHHHHDHGHRTPQPQTTLSHDPSQAVSSRHRESPYPLVSVEEAITLIFQQLRPLALQEKQVDPQLRGHVLGEDVYAAQDVPLTYTTSVDGYAFRSTDPPGIYRVASSQTHSTSDLLPPDSIYRINTGGPLPAGTDAVIMVEDTRLHSTYKNEHGEDVEEKEVETLAQVPKGENIRDPGSDVSKGDLVLEKGQILHSAGGEIGTLAFVGRTKVWVHMKPVVAILSTGNELLDLQSPTPFEGDGWGGIWDTNRPSLQAALEGMGYEVIDLGIVPDDIASHVAALRQGLTSADVILTTGGTSMGASDLLKPVIERHLDGTIHFGRVKVKPGKPTTFATIPTPTGRNERVPLFALPGNPASALVTFNVFVVPALRRLGGWPVERCQLPRIRVQIHDVMRLDPRPEFHRVVIKAGPTGLKAYSTGGQRSSRVASLNGANGLVALPARRIDGPDRVVAGESVEAVVIGELQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCT8</accession>
    <name>A0A401GCT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0211350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610846.1">
        <property type="nucleotide sequence ID" value="XM_027755045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCT8"/>
    <dbReference type="STRING" id="139825.A0A401GCT8"/>
    <dbReference type="GeneID" id="38776850"/>
    <dbReference type="InParanoid" id="A0A401GCT8"/>
    <dbReference type="OrthoDB" id="2780918at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46768" checksum="E91764CFCB12127B" modified="2019-05-08" version="1">MNLSTIDEDVLLLIISLLRSYDALSLSETSRHFHAVALPRALSSVTLINHQQLTAFCTYMLSGSSARMRFLKSLSVTLGDGNFTNAHLLADLLEHAQSLTSITVRNAVSFMQSEPRIGDALAALEGINDIELTAVESTVHEMLSKFRSKPRKVSLTGRDFPLRLSHLPLQNAEYLEVSCAIIEDDMPSGGCYAGPQWLACRYIALNLVQIPSIVFMHAFPNLEHLHCFATNVSSPATRTVHSSQNFRHIVRPIHCVTLRLLCTNHMPPEAEIERALCVLRYVRPAVLYLVIHLVPPALLWQRIVELSPQLQYLTLKLYLRMDISDWLATILPLLAPLDVLCIRVSLMEQQEQHQDELRVALAQYMSSLRYLAINCLSLDDPLGKVYAWWRIEGSGAEQRVVEMPREVGDALWRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCX4</accession>
    <name>A0A401GCX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cleft lip and palate transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0212400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610951.1">
        <property type="nucleotide sequence ID" value="XM_027755150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCX4"/>
    <dbReference type="STRING" id="139825.A0A401GCX4"/>
    <dbReference type="GeneID" id="38776955"/>
    <dbReference type="InParanoid" id="A0A401GCX4"/>
    <dbReference type="OrthoDB" id="2563191at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="850" mass="92568" checksum="3C4E61770C53BA52" modified="2019-05-08" version="1">MGSTSQQQGYACRCLNVRVLPLPPPGQPPTVDNDYDSVYVDDDGLSVAHLQLTLRSRTRPVQEKSGETTRSTRYTSLTCLLCQTPVYRVHQIVHPDVEEAEGPVLPTDDWAEQDMLKSTSGWIEVYKGCLTRECISQAENSPEYSKLFSVLLPPELPGSAPAGDSEPPYKSLPQQSGPHLPPLPPLFAPPPFSPADPVFSHLSSIAAAESENIRNGAEEYIANVTQEKVAEVQAADLDLKHKVELLWSKFRETVDKFEGKVNGIAPHSTSRRRRSSVRRPGHGADPIPVEASSVRINDFVPIHDLHPRTSAAAAFPKVASALSASLATSSFHYPHAHRERDASGSSPSPSRSSVTRVKTPSIASSRTAASATNGEGSSILEAFRRNMDESKDIATSFQYVMNMETMMEGVRGRQDSNSHTVDLSVVEGNQAAESSAAAVVRARSPKAGKSSIKKPKDEERPVEPTQDVPPPSTNGKAEDGHPEGSTDKGKRKVTFVVKPEVTIIDGEAQPQEAVKEADEVIFDMEGEGGERKDTGPVLDPSSPLSPKSPTPDSPRAPKRPPRARKSNDFGPVSFAALRPASLPTYSTVPPPPRLREEPAPAATPRPQAMRESLLVPPDGSRQVNGNHDVIANGKEDSDDEENFGLQEAEILRLVAASTPSHRGAWKKNSKAWQLFVNRSERRMRDADPEAIAEEEESASSVEYTSPGTRYTERPEDEHVLEYGDDDGQDDERWSSHRGVASSLPIPIDRSGFGLPSYQLKTSLSDRPGVLVPALHKVSSAAMRKAAYAERDRSRSIDPGALDCIMDEDEEEEEEDDGDDLEAGSRGRQRALQILKARSELPPAGMWRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDG7</accession>
    <name>A0A401GDG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine racemase</fullName>
            <ecNumber evidence="13">5.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">D-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">D-serine dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">L-serine ammonia-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">L-serine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0214340</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-serine = D-serine</text>
            <dbReference type="Rhea" id="RHEA:10980"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="5.1.1.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.18" evidence="13"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611137.1">
        <property type="nucleotide sequence ID" value="XM_027755336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDG7"/>
    <dbReference type="FunCoup" id="A0A401GDG7">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDG7"/>
    <dbReference type="GeneID" id="38777141"/>
    <dbReference type="InParanoid" id="A0A401GDG7"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006563">
        <property type="term" value="P:L-serine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000041">
        <property type="entry name" value="Threonine ammonia-lyase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="18">
        <location>
            <begin position="26"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE80224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="326" mass="34148" checksum="D56E8DA0DC1BFCC9" modified="2019-05-08" version="1">MASSSISPLPLTRPSVQAAYEAIKSRIHRTPIFTSSSLSASLPGRNTLYFKAENLQKGGAFKFRGASYSLECLKEDELARGVCTHSSGNHAGALALAAQERGVKCYVVMPNNSSQPKIAAVRSYGAEITFCEPNARARADTLAAVQSRTGATFVPPYDAANTILGQGTALLELLERAPEPLAAVITPVGGGGLLAGTALAADGTGVRVFGAEPAGADDCAQGLSEGRRREDVQANTIADGLRTPVGVLNFPIIQDKVERVIVVSDEEITEAMRLMWERLKLVVEPSGATAFAAVRSAAFQELGITGPVGIIISGGNLDLSKPLPWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDK3</accession>
    <name>A0A401GDK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0214630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611165.1">
        <property type="nucleotide sequence ID" value="XM_027755364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDK3"/>
    <dbReference type="GeneID" id="38777169"/>
    <dbReference type="InParanoid" id="A0A401GDK3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="92" mass="9576" checksum="74E3FBE5A4D13630" modified="2019-05-08" version="1">MAITNGHAPLPPPVEGACSSLGPEEHWITHNVRPVSADNTVRPPLPRCPPLALDPRGEPCGLLRGAPTLAASALPIRGAPKVEYDTAEADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDQ3</accession>
    <name>A0A401GDQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0214690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611168.1">
        <property type="nucleotide sequence ID" value="XM_027755367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDQ3"/>
    <dbReference type="GeneID" id="38777172"/>
    <dbReference type="InParanoid" id="A0A401GDQ3"/>
    <dbReference type="OrthoDB" id="2960452at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="642" mass="70073" checksum="9B17CEA852734726" modified="2019-05-08" version="1">MRVPTARAIRRAFAAPLHSTSTADTLHHLHSRQCDHHADLPLERQYRAWPTAKHAAPLRAPPPRLSPSHFATARGLTNTRTSRRANPNAAPSPSHNTRTRSVRIFLCYFAYILLTSSNANTVPRPTKTRAWTARAIPHAFAPLSTAPRPPTPSTTYSRQPDHHADLPFECQYRAWATAKHAPPPRAPQPRPSPSHFATAPRSTTARTSRSNAKAAPRPSQSTHLRCVRNFLHTLAPVSAPCPDSECRRTCPNSRTANNSHLARFPLATATMASVTDAPATTTGSKCKMRHLSPSAPVPSPAKRQKPEDSDDIFSPTAHTDSTASDTPADDAHASHRPDETPGKPYRNKGKRVEKTRTPTEVLQSLSKLRETLAVTRAMNNVFVLVQPVYLKRAFPSNIAERLDHVSIATAHDIINLATADPTALHFVTIGASDYLQLKTSTHLTLFSVVGSVTHSDLISPSGRSRQLCVAPSALTWPRAAAVLGAILNRRTLVFPSFHAGLSFSTRLTTGTSNTPTKIRGMAPATPVNAQRGPPPVLPADRDVPTFDGCKPFKFSMRSISMLPKIHDDLSTESAVLLLFTLGKYIKSHPELDDENADTTISLNIQSIVLLANPGSMPRGFLDDEPMPLLGVFRPNSEPDQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEF0</accession>
    <name>A0A401GEF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611424.1">
        <property type="nucleotide sequence ID" value="XM_027755623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEF0"/>
    <dbReference type="GeneID" id="38777428"/>
    <dbReference type="InParanoid" id="A0A401GEF0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="152" mass="16751" checksum="A779FB804AB4AA50" modified="2019-05-08" version="1">MTDSFNIRCEARIQRIDNYDHARDKDVADLEKLVPISPTIGIIVLVILLFAVLLLALLLLLLVLFVLLCHFVVLPQDLVVATSLILPDIPFSQASSAGVQALANTTPPSSSSSRSLDFLAISSSPTQDLAIPHLSCPSRRYRKYLLMKPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GER3</accession>
    <name>A0A401GER3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pyranose dehydrogenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0303480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611544.1">
        <property type="nucleotide sequence ID" value="XM_027755743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GER3"/>
    <dbReference type="STRING" id="139825.A0A401GER3"/>
    <dbReference type="GeneID" id="38777548"/>
    <dbReference type="InParanoid" id="A0A401GER3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="610" mass="65380" checksum="0CC64691A2E7C7B4" modified="2019-05-08" version="1">MGASYSRSIVSDPAQFSTPAGDGKSDRSTWREYDYIIVGGGTAGCVLASRLSEDSDVTVLLIEAGKSHERDLLTRIPLACTKIFKTATDWSHETVPEKALNERQVYWPRGKILGGTSAINALIYHHCAPEDFDEWARNGATGWSFDDLRPYFRKSEKYTPNPLFPDVKSTDRGSTGPWQTTHTSDAAPINTLIIEACESMGVPYNGDLNTARGTLGIAHFSGIVDRKGQRSSTASAYLTKDVLSRPNLTVAVNTTVDKVLFSTAENSSPRAVGVEVSTAPTSPRYRVAARREVILSAGAVATPQILLLSGVGPAAELEEVGVPVVKDLPAVGRHLSDHISCGPLTFRAKSGFTWDHLSRPLAGAIAMFKWLMFGTGPLSALGPSSGAFVRSDDPKFPFSSPGCESGPVKDLTSGPGAPDIELVWSPVVFIDNGFVEPPAGSYGFTAGAIALRPESTGSIKLKSNNAWDKPLIHANYFDSESDMNVVIRGTRFLLRMAHTEPLASALDLRPESQDKSSFFWPGDADPEKVTDDELKEWIRRNSSPSFHPVSTARIGQGAETSVVDPSLRVHGISGVRVVDASVFPGQVSGHPCAVVVAIAEKAADLIKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEX9</accession>
    <name>A0A401GEX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0304040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611598.1">
        <property type="nucleotide sequence ID" value="XM_027755797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEX9"/>
    <dbReference type="FunCoup" id="A0A401GEX9">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEX9"/>
    <dbReference type="GeneID" id="38777602"/>
    <dbReference type="InParanoid" id="A0A401GEX9"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="8">
        <location>
            <begin position="225"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="590" mass="65336" checksum="2D64E5F0E05C02F5" modified="2019-05-08" version="1">MPSTLCTAKASYKKLPGLLELTHTHLLWTQDGKKVPSVRVSYAEAASLFCSKEGAAQTRLKLGVVGDDTGHNFTFTAPQGVALAEREKFKNELTAIISRNRSGVATPASAVPPGTPVPARPITHGHRPSVQASRASTSRAPSTGSDSHASGTPVNDPTSEFRLRKKVLLSNPELAALHRELVMGGQITENEFWEGREHLLLAQAATENQQRGKPGQLVDPRPQTMDGEVKIVITPQLVHDIFEEYPVVAKAYSENVPNKLSEAEFWKRYFQSKLFNAHRASIRSSAAQHVVKDDPVFDKYLEKEDDELEPRRLRQEGVDIFIDLGATQEDHDETGNARDVTMQAGKQRAVLPLIRKFNEHSGRLLDTALGEPAAKRKRTDEGLDRLAQLDLEDLHDNQASAGILLDMQDRQRYFQGRMESSAPQTPNPGLDLRTALREAKESMQGWSADLSQLKIERKASDTALLGMTQNVSARLEVKMKKHDLPEGIFRQMTTCQTAANEFLRQFWLSIYPPLVEVQTLSMSTPVQKAAKAAKMVGYLGKTHEKVDALVRAAQAEGVDPTRVRVAMQPILDAVDKALAFSRVRSSKMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEY5</accession>
    <name>A0A401GEY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0304490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611643.1">
        <property type="nucleotide sequence ID" value="XM_027755842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEY5"/>
    <dbReference type="FunCoup" id="A0A401GEY5">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEY5"/>
    <dbReference type="GeneID" id="38777647"/>
    <dbReference type="InParanoid" id="A0A401GEY5"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="124"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="301" mass="33522" checksum="7BC60FF983474060" modified="2019-05-08" version="1">MALGMLDIAQAQALYDVARKWFAIVPPLQVPITFFIGAPFGRFAPENESIFLVDGIKAWIAMELVAPIAFTYTYLQSPLSPTHSIPPLTLSTPATLLAAFFLLHYLNRSLVSPLRSPARSKSHIIVPLFAIVFNVVNGCLMGTYLSSPGAQTFLAEAFARPLFWLGVGMWAAGLAGNVLHDEVLLDIRRKAKAKGKARESIGDGKNKQEYYAIPHGYLYSLISYPNYFCEWCEWLGFALAAAPLPSFASGTALMATLSPPYLFFLSELSVMLPRAYRGHQWYRSRFPDYPKERKAVIPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFA1</accession>
    <name>A0A401GFA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0305860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611779.1">
        <property type="nucleotide sequence ID" value="XM_027755978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFA1"/>
    <dbReference type="STRING" id="139825.A0A401GFA1"/>
    <dbReference type="GeneID" id="38777783"/>
    <dbReference type="InParanoid" id="A0A401GFA1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="99" mass="10900" checksum="0027D22117364341" modified="2019-05-08" version="1">MAVRILARYTRGFRAVFITNASLSAAATLVSVLMIRHKELTRGDEEGLRMDDCAQEKAAREEDRDPEKAVTSSSRAEDAPMGILRSQSLREGSSDERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFG8</accession>
    <name>A0A401GFG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase gedA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0306500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611841.1">
        <property type="nucleotide sequence ID" value="XM_027756040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFG8"/>
    <dbReference type="GeneID" id="38777845"/>
    <dbReference type="InParanoid" id="A0A401GFG8"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="80"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="260"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="452" mass="49953" checksum="7BA3FC3780BBC1F0" modified="2019-05-08" version="1">MAPSPRTEKLLALVDLVANAAQIVAEEWEKEEDAASVKGYQGTPLPTVELYNAQRTIISACGSFTELVHAPQSRLLEVAAEYFEARALHIATEQRVADHLSKVDRTVGMSVFELSKIIGIIPQKLSRVMRTLCSTHIFAEVQEGRFANNSVSECLVNNEPLRAYIVSLAWDIYTASDKLPEVLTDPIKGASNSVTCTAFQEALGTKLARWDWLEEGLGQPDGTVKPRPALEIFGLAMLGGGRVLGTPLYYDFPWESLSSATIVDVGGGVGGMSIDLCKRYPPLSFVVQDRAPVIEQAKTVWQREQPDALESGRVKLMPHNFFIENPVKGADIYLLRYILHDWEDDRCVDILASLRTALGPHSRILIADQVMNTTLGCPELPSAPYPLLANYGVFTRFAHERDLDMMTIINGAERTPAEFRVLAERAGLEVSRIWECRGIVSITEMRLPAASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGF7</accession>
    <name>A0A401GGF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0310010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612187.1">
        <property type="nucleotide sequence ID" value="XM_027756386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGF7"/>
    <dbReference type="GeneID" id="38778191"/>
    <dbReference type="InParanoid" id="A0A401GGF7"/>
    <dbReference type="OrthoDB" id="3222645at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="465" mass="52805" checksum="A8FFC563B305834B" modified="2019-05-08" version="1">MSISFAPLFKIAWKLGLALAAFKCGFYIASHLGRAGTILRIRSFPPTVSRHVILQEQNVQLKAEIEDSKRSIKDLLDRLQHEKERAKHEVERLGQEIDFWRRMEGLARVGIQTRDEKLQQQQVLLAVHCDELRVLEARLLNVTSLTHEQLHMQERAIREALLDRQRTELLNAHSYLSPVNTVSDSEVVQMLRSLNLEISRTATFLTESFRAEDRRDGEGITRAFERTKESVGPVIAELLESSRQQEDPILVHFALQASIASFSAGIISAWDFQHQSNSIFAGIYKQMLKSETQNIAGRWRALTRQYSKLRLYNGRDLSPGFIHQLADLLCNIMVLAGARIDTEQTLQLASENFQNIVHLALDIQRIIGEDITSCDLEILLVPGEEFFDPENMEDVYGGEILDDDGLPPVFCTSHLGLRRHEKAEADVGDDIHSTILLKPKVVLEAFVYELMGAEEEEDPDDTEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGS8</accession>
    <name>A0A401GGS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Superkiller protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0311070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612292.1">
        <property type="nucleotide sequence ID" value="XM_027756491.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GGS8">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGS8"/>
    <dbReference type="GeneID" id="38778296"/>
    <dbReference type="InParanoid" id="A0A401GGS8"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="702"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="984"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE81379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1431" mass="157784" checksum="A61B97D47AB6DE2F" modified="2019-05-08" version="1">MSAFVKSKLKAARDAIGKKDYGTARDASLGVLEYEPDNYNAHVFLGLSLFNLGQVDESEQAYRKAIAASPDQALAWQGLSQQLEQSKKWENYAETLEHLSQLFAKNNDAVKCAETLQKLIDLRRNRSSPTQLAETLSTMLPSSSFYSTLSTLPPPDPTSPTSTSTYPTQVAVHDSLPVLEEIVSIHEREEKTKVEKDVSRRRMRLGAAGPEQLQREVEREVLEISPLPDLYNEILNHPNTSDELRRTTESKLLRHKQRCLHVLPATGESAAQKAQVATEVEELVNGMVLLGIPDELAWTSFIEAKDAARIEDYDFSILQQFVTSFPSLPLAKLILGYYGYMGRQSSDRDDSDGIAILPHQTKEAQEEFVDAMADAFGSLLDSILAHRMMVDIYEREDELENVIKVAESGLELVQRAELDNGKSLTQVRKAFNIALGVSLVHHFAPKYHSRALGIIDQVLSQDPDNVPCLMGRGFVLQRAEKWAEAGELFNRVAHLIPDDRNHGIRAKEEQAWCQAKRHDPEGGSKALAAVVTVLDELDGKDADKARCWWRLGKCYWDMGDHCREEAYRYFVTSLRHFPSFAPAFTSLGIYYSDFLSPPDPIRASKCFQKAFELDPREASAARRLAEGFAEEREWDLVEVVARRTIDGEGGPQSGTDTVAAARYLPVNAWAWKAVGVVELNRHSYPPAIQAFQIALRTDGDDQLSWLRLGEAYSKAGRFAAALKALERARELKPEDWISSYFIGEVQRQTGAYEEAIEAFESILLDHPSEVGILISLGQAHLDLGRVQLATAYTARAETSFVSSIRVVLRLIDASPGFRRVAWKIAADAVFQLSQFSTFSDEGGVRKVAADLTTLVSDHPESGLSGILSSPLLLNDTRDLSLFLLEISLAAYDYRIILGSLDEAAGASAYFDLGVALHAYARRVAPSTKQKRSQQEAVQNFKEALRLDPGNDRYWSGLGDATFLSQPRVTQHAYIKALDIDSKNPITWTNLGLFYLYHDDAELANEAFYKAQTLDPDYAPAWVGQGLVATANGHDADARALFEHAVGLTATVPEADVEFAKRIFHRPNTTASASAPSSDALFPAFFVLDRFCKKQSQDAAALHLFGLVCERIGHLELGIDSISRAISLLEAAYEDTEDPVIERQFTIAHTSVARLRLSLGDYGGALESYQVAMGLLPEEPEDRNSRILLVQAQFGSGLAHFKLGQLQDALTFLQAAMGIASEDSVLRGHIVVLLAQTLWAVGTEAGRESAKAQLLQSIESDPENLMAINALAGMGILTDDDSLVDAALSEILAQPLDRRLQRDPDRDITYLLIEHHLGQGDSTQALSVAQKAAYAEPSRPEIRRQLASLTLQQGESGAALAVIAGSSAARDDNLAQLRESLALHAVALSLSGHQDPGVNSEARKLAQKAIMLGPWDLHNWRALGYVESQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH22</accession>
    <name>A0A401GH22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612381.1">
        <property type="nucleotide sequence ID" value="XM_027756580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH22"/>
    <dbReference type="STRING" id="139825.A0A401GH22"/>
    <dbReference type="GeneID" id="38778385"/>
    <dbReference type="InParanoid" id="A0A401GH22"/>
    <dbReference type="OrthoDB" id="2802356at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="437" mass="44015" checksum="472522C7173D8E26" modified="2019-05-08" version="1">MSYNYYQSGPGWGTSQYRFGRPPTPGFQPTPSWGGLDFFRAHAINGEPEFYQSIVTSMPQFESTGVFGLDEARYWHRRIYGGMVNLSQVLPTDIGSAAAYEAYRLYKYHNICAPLGAVPERQREGLVAMAIAETTRLWQFTGRSLDAYGIRAAAGSAAVTASRIAESVMMNSAMGGMPGINGAGMGMGYGGGMMGGMGPGMPGGMGVGMGGMGGGMGGGMGGGMGGGMGGGMGVGMLGGMGVGMLGGMGVGMLGGMGAGGPYTRDYAYDMPARSRIRRSSISSYGAGPASVSASPMRVPAVGASPYGGSPGMGMGMGIAAAGSPYMGAYSAGMPGTLGAGGMNGAYSTGGAYPMPGAGYAPGGLGGGIPYTTGAPVTILPSQGAYGSGAAMYGGMPGGMPGTTMAYGGQPMQPGSTIVIQEPRRHRHRAHSVDPMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH46</accession>
    <name>A0A401GH46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0312450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612429.1">
        <property type="nucleotide sequence ID" value="XM_027756628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH46"/>
    <dbReference type="GeneID" id="38778433"/>
    <dbReference type="InParanoid" id="A0A401GH46"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="59" mass="6094" checksum="094C1C310322EE45" modified="2019-05-08" version="1">MANRGSPSISDLQNQIRALSADVSQTEAIALKVQRAMEIIRAALGINTGGASPSTPPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI35</accession>
    <name>A0A401GI35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0402020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ZNF598/HEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612742.1">
        <property type="nucleotide sequence ID" value="XM_027756941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI35"/>
    <dbReference type="FunCoup" id="A0A401GI35">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI35"/>
    <dbReference type="GeneID" id="38778746"/>
    <dbReference type="InParanoid" id="A0A401GI35"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16615">
        <property type="entry name" value="RING-HC_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057634">
        <property type="entry name" value="PAH_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041888">
        <property type="entry name" value="RING-HC_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056437">
        <property type="entry name" value="Znf-C2H2_ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23202">
        <property type="entry name" value="PAH_ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23230">
        <property type="entry name" value="zf-C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="74"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="549"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE81829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="733" mass="80172" checksum="E23CE21CA7473324" modified="2019-05-08" version="1">MPSATGTATQTRSAGQRGRRGRGRGGNRRAPQDAGKGTVAQRAPSEEAASPVKVADNSDKSAEAVDQVDDAVVCWICAEQVKYWSVSECNHRTCHVCALRLRALYKKLECTFCKEPQLSVIFTTSPDAPWASYTPDLIPFRDPKLSISFETQEMMEETLILLRFNCPDPSCDYVGNGWSDLRLHVRAVHGKLMCDLCIRHKKIFSHEHALYAPNQLPIHVPSIYRAHGSSRKDKEQIEGGVHPLCEFCRECYFSDDELYAHMRERHEECFVCKRNEVTDQYFRNYDALEQHFMHAHHPCTQPQCLARKFVVFGSALDLKAHMVEDHGAEMSSRDKRDAMRIQADFEYEEVAGSRRGRRGGGGRERDREPPPAPLPPSPSRLNAAGARRREAFSGNLTGHANAASNNVTPNISRPPSPPRNDGEPTTVERNAGLASRISSLAPNSTAAVTAIQAAIRSYRVSESAARDLILTVWNILDHNLDGTASIINSLVDLMDEEEKKKDLLSAWNGFKIEQRSQFPELVPTAIGTDWAGVTSGRVLNAKHLTVSRSSSQSSRQVWDRVARAAASSSTSSSAFPPPRPPERFPPLQSASPSTTPFRQPQRTTPWASSSSAAPPPVRVPMSVPGPGASSKPAAPVLSKSAFPELPTFTSTRAPKGAVSGNQSMRRILGDSTPATSAWGSGKTAANGMNGGTPPSTAEEPEEEEVGSREQTPGKKKGKGKQKQTLFTFGSFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIE0</accession>
    <name>A0A401GIE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0402550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612794.1">
        <property type="nucleotide sequence ID" value="XM_027756993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIE0"/>
    <dbReference type="FunCoup" id="A0A401GIE0">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIE0"/>
    <dbReference type="GeneID" id="38778798"/>
    <dbReference type="InParanoid" id="A0A401GIE0"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="4">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE81881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="372" mass="38568" checksum="DE70645AC4847148" modified="2019-05-08" version="1">MALSFIGKPISLISHSDVRYRGILAGIDPAASTIQLSNVYSMGTESRRPPDQFIPPVQEPYAYIIFRASEVKDLAVDDPAPQRRSVHDDPAVLGASAPMAAAPPYGQNFQVPPAGVPPQSAQPPQQNRQPSFSRQQSSQSSTSGQQQGGPAQAAQAGASGSPSSTTPSGGHRQGRNNSVHTATASLETVERALGDLRVANATANGAPVPRSGRRGRGQGQQEHNIRVPVADFDFQSSNARFDKAALGPSPRGTPKADEVNGTSADDKEKEKEAEPVAYNPKKSFFDLLSSGSNGPSADARGGRGGGGRRGGGRNRREEERERNVATFGEPGGVGLMGPGAYVAGWGGYGRRGGGRGRRGGAGGGDRAAAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIG3</accession>
    <name>A0A401GIG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translocation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0403700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612907.1">
        <property type="nucleotide sequence ID" value="XM_027757106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIG3"/>
    <dbReference type="FunCoup" id="A0A401GIG3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIG3"/>
    <dbReference type="GeneID" id="38778911"/>
    <dbReference type="InParanoid" id="A0A401GIG3"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="261" mass="28510" checksum="244303AA0964D1DB" modified="2019-05-08" version="1">MDSVLVPVLYVVVVFGSLLVFSSFYRHHNASKVSEPYFPPHRERNIYVSLLRKTDPPASETLLKAALVRRAMTDVTRIIRIREDKPALQNLLQKGSIGDDLWNSLLAAEKEMEAEILEVAAEANTFVEGWGTVIFQTATEMMHNEKMRGMLEQNSAARVEKEKKYGRSRVSRNAIMPSNSNSTSLLPMSSSTQIPASATLQAAATALPETPPSSKSTNGLIPPPSASADSVVSSDGEGHFSLPSSPRSPSKSSAKKAKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ96</accession>
    <name>A0A401GJ96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0405980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613128.1">
        <property type="nucleotide sequence ID" value="XM_027757327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ96"/>
    <dbReference type="FunCoup" id="A0A401GJ96">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ96"/>
    <dbReference type="GeneID" id="38779132"/>
    <dbReference type="InParanoid" id="A0A401GJ96"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="165" mass="17900" checksum="5C9329F2DDA9851D" modified="2019-05-08" version="1">MVHILGVLLPDRQLAKFALTHFYGVGRGTAAKICARAQVHSRCRVRNLNPDQIISLTAFLSAPSAADPLPPYPVAPPSYALGTASVAPPVGNVAAGPPKESAGDKLRNIRIMNELRSEIRDNIAHQRMIGSYVGRRHAMGLPVRGQNTQTNAKTAKKLNRMERYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJB9</accession>
    <name>A0A401GJB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0406350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613164.1">
        <property type="nucleotide sequence ID" value="XM_027757363.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJB9"/>
    <dbReference type="GeneID" id="38779168"/>
    <dbReference type="InParanoid" id="A0A401GJB9"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="206"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="815"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1423"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1514"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1129"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1464"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1515"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1639"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1671"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE82251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1688" mass="188732" checksum="A96E5AA80E1F5FB1" modified="2019-05-08" version="1">MRDDVHWMEPVAVASTRPTTRRFTPQDGTFAPQLQAGASGDEHQLGKPISLSSPIRIFPEPPTMEASTSRRLTLDIDPTRPIPVTTYGWTFDGLISKGNRFKPVPRVSALASVRELEEVVKNHEQSGIPLVIENWHERPEWRKDIFNVDWLLEHHGNDIFPVRNVHNRNDTTIMLKDFIQKSRTMLPCITPGENERLYGKDADCPSDWRDWLDSDIFPSELLPNGSNNLLQHSDEVEHLMCYLGIGDTFTPCHKDLCASSGHNVMCYTENDGCSYWFMTASSDAPDVAKYFQDVLGQELDWENHVASVEEFAQAPFDVYVVEQKLGDFVLVPPRSCHQVMNFGGLTVKMSWSRMTIAGLSIALHHELPIYRRVCRAEKYRIRSTIYRSLLYLTKELEETLENSLDLHEPSPSIPVRRSLRGNLVDYASSTCSEESSLRPSPLHDMPSVPHAGSQEQAIKLGALVKLFDEILCEEYSPDHQKLRRVASNNNASWHIFSGRGKNHPSIILQPPAAESKDDEDEEGGCGFYGCDFCGADIFQSCFECRKCICNPDSEEERLLICAACYVEGRTCRCESMMPVQSRSFETLLQDRNKAVEVLLRGSDSKMWVGDWECSELTESTVAQGDDIPIFEAACILHDLRQTARSKGTETRKCRATKPHNVPLLEVLPCNMCHGGKCFPHILKNGIHSAEALLAYRRDKKQEYWHQMHKDSKGRLAEILPKLEEAERTGSFSKLRDRLVIAAQRYNQCQSVNGAFTKPGWYDHNDVESEDHTDRSDMPEERVGKSSIEIGHNASTADADAPPSSPLTDIEDLTEEKSQTIPTTLSRKQALSSTSSVTKRSPPLSLTVPRLHPTEGLTNEQLLNQQTRTSQTTSRRRPIFDCVLMSLSHRAGKRALSPVAPTPRKRVRTGSEGRSKTGHRHEESRQPPSNTGEEIDYVNRDYATDLAIALSSANNANSANSGIRERVMRSSTGKRAVRRRVLSSPSELGPLTTTSTVVVSSAVTAKDTQHLPAKRNLPEPSIPVPLISESMSISRGKDDRPARKSASVGTEAQSAASSTLGPGCKIGPPTRQVRAVQPSRTPNVGRFTATSAVTVETRHISKIKSRIPKSRTKAGPPNLHADVMKLTGQGDASGQSANASRESEPHAAPPALKRKGPPGISPKEMESRDKRKADRNASDLPVADSDDEPLCNRKNNLREGKRKFIEEPMLATSEGPTPVTNEGSRISNEDRTKLAVQEDIRLLRSILQDIRREQDAMRVKQEDMHAREDALRTMQDTMQKKQDAMQDAMQEAMQDTMQKMQDAMRDTMQKTQDAMQDAMQKTHGAMQTVQGEMQTTLRSTQVELNVERARLTQVQQQCDSVKFLLSRAESSNQQMPQSTPCEHEEEIRRWSHVYATAAFQGLLTKFFDGGIRGMIRSEVPMGSCSEMSMAKTPPRTPDIHPSVNPEKSLRESNSGGGLETHQDLQRPSSLPPQMQVSYDSRYHVSTSADVSYNSPQQIATSQGGTSNVILTADPNQWKEDGHDDGQDSRSQASAANEPGEGPHVSYPQPHNQGRSARMSVNVDYPEQSATHRAEICASSTEQWGEGAYGSVEGRYSPNRREGRNPSEQVFAARSHFPTGWSSRTPQPRSIRDGTAGPEFRGQEYHNNDHRDRGDYRGEGSRSSRYHGRRQYARYDRPPNHTMKQDFRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJM4</accession>
    <name>A0A401GJM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0407500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613279.1">
        <property type="nucleotide sequence ID" value="XM_027757478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJM4"/>
    <dbReference type="FunCoup" id="A0A401GJM4">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJM4"/>
    <dbReference type="GeneID" id="38779283"/>
    <dbReference type="InParanoid" id="A0A401GJM4"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="341" mass="40798" checksum="29B6286EB81D4BFE" modified="2019-05-08" version="1">MHGVKRVRYSQEALQAKEQRERAKLKEYLVLTDEVLTKKKNSDWSRNAFDLTTRLLHVCPEFYTVWNYRRNILLYGIFPNSSPTDVNVILSDDLSLTTSFLKQHPKVYWIWNHRRWCLERVPECPSEADPDGWRKSYWSKELFVVEKMLDVDARNFHAWNYRRYVLSSMPVKRPEQTELAYTTRKIESNFSNFSAWHQRSKVLSLLWDAGKLDPKKSREYEFDLVKNAMYTDPEDQSVWIYHRWLIGNGDDYEILCREIASIQELLDEQPDSKWCMESLVFYKWLVLQNHRPRLNETEQNTLLAECLSYLSQLQILDTNRRQRYIDLSAELRNTSGECRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKZ1</accession>
    <name>A0A401GKZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0412000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613727.1">
        <property type="nucleotide sequence ID" value="XM_027757926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKZ1"/>
    <dbReference type="STRING" id="139825.A0A401GKZ1"/>
    <dbReference type="GeneID" id="38779731"/>
    <dbReference type="InParanoid" id="A0A401GKZ1"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15332">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15332:SF175">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019086460" description="EGF-like domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="793"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="853"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="893" mass="92225" checksum="F894DC3019EBB83A" modified="2019-05-08" version="1">MFSSLLTLPLIFGASVAAQSLTTVVCVAGQCLEGYTNTTLGATLSASGAATSLLLLPGQYTSTTNPAVLHDALTASGASLSASPGFAVNSTVSLPFNLALQPGIAAYPAANFSGAASFISLPNSGSAANGSKQLSSGSFALSSNVWAAVAASTSNDRVIFWETVPDVSQLPANTFNSPLALLNMQSSACSPPCAGAGVCSTNGTCACPTGFTGSSCQSCATGFFGPTCAPCPAGCADCDQGMSGTGKCLVPSVSNPPSSCNCVNGECGSNGQCSCLSGWTTASNGTACAQCAPGYFLDSSGNCEVCQLGCTECASGSGDCITCKSGFTQNANDATQCVAIQSATSSGTVCPDSGFNNGTGCAACSPLCQTCNGPTSNDCIICGAGTYSFNGSCVQTNNNGVCAGSNLIANNNKHECDTCPSKCTTCEYTTFNTLSTINQAKCTGCLPGFVLSDGACVESCPTGTFLSPQDNLTCTACDSSCGICAGSSTFCLTCANNMLASNGTCVSSCPSNAFSSSGSCLTCHPDCATCSGGAFNQCSSCSSNLPVLTNGRCLPTCSQSQYFDTTSSSCQSCDSSCSSCSGAGASNCLACADSSHVLRGGSCVSASCTGSSGVVSGLGLCLSDLVQTSAKASGTSSLPPLPSITGLTSPVSNTNTTMRTRLAWWQILLMALGCAFIFVMVLLCWRRRMRKKRAQATAQFASAKKLQPQGWRMRLVRFGERLFGHKRQQRWIVPDDAEAQDIKLQKMRAAEEARHDHDVEKLISSYEYSRHQPSPLPSLRDYDADDRRRDLRRADTYGPHRLSAESLSTGSLYTQLTGQPRRGPAPRLPVKEEELPSRFSDSTYATQVRELLAGPKPPTPAQEYAMSVSQHEPRGSYWLKSANTGGSRNPFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLN2</accession>
    <name>A0A401GLN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0501310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613998.1">
        <property type="nucleotide sequence ID" value="XM_027758197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLN2"/>
    <dbReference type="STRING" id="139825.A0A401GLN2"/>
    <dbReference type="GeneID" id="38780002"/>
    <dbReference type="InParanoid" id="A0A401GLN2"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="45"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE83085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="498" mass="53356" checksum="B36608EE02D236E6" modified="2019-05-08" version="1">MLLLSPLISVPAQIVGALHGSPRELGTRETTVGSSNVTNVSNQDYYINVTLGGIPFEVLIDTGSSDLSVSGSVPNAHDTGKIGDVSYVVGGAKGPVQTTELELLGYLVPDQAFINQLASNMSLMGSGVIGLGPPSGSVVLSTLGSSTGKPALEQIFEQNKTTPNYLTVLLGRTDDQGGDSMGYLTIGETLPQYSNITSQPKLAITTVPSSDNGNQYWQTLLDADGVIGPTGESVKIQSAVSSTSNKEQLTVVFITGYSLPQVPAAIAEAFYGSVPGASLITDPTVNGKIWRVPCEYEVNVTFKFAGLSYRVNPLDTVVTANAIDDNGEKICYGAFQPSCAQTQEYDIIFGIAFLRNVYMLINFGDYVDGSTTNRAAPYIQLLSTSSDTAQMHDDYVSLRGALFWRPTPLPPNYSSGTPWVQRHLLLIISLSVVISLTLIGTTVVCLAKRRGSKTMGAPMRSMLIDQKYQTLDKYVPEQEDILPLLDPESMPQAWDSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLW2</accession>
    <name>A0A401GLW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0502480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614114.1">
        <property type="nucleotide sequence ID" value="XM_027758313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLW2"/>
    <dbReference type="GeneID" id="38780118"/>
    <dbReference type="InParanoid" id="A0A401GLW2"/>
    <dbReference type="OrthoDB" id="2138242at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="201"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="637"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="640"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="755" mass="80707" checksum="A6D1653EC618770F" modified="2019-05-08" version="1">MGTQPTQSLPSFAQAFSTPSLSRISSSSNALPPIQRRLSPHDSHGSPSAQDPPQPPDEPYVNNANNKKRLHAETSSPKSNDEGSDSDGRRSPRIVRIKVEADYDTFPSSSQLKTMSQTHETDSAVAPSPSYSKPPTSKRRRVTISGNLSPINTDVRTPSDNVNKSISPVVMGFTIKRDDPVALEQVRSMLTVKQQQKELIEQRRGSTASIVSTGAPPAVNVVNHLPPSDERPNPLKPIAPARTPARSPNFPPANTVDRRRSIAVISSAPPQGQGTSSSSARHPSPNTVIAPGPQLQPPPPHAPSGTHTFVYTTNPPASSHTHALPPPPISFARRRAGRQLGGAKSKPADIMISPRDPQSQPAIQSAPPVPRADQGVPGRFPPMALPRLPPPLTGTSQRQTVGRVPPTPTRLSISRSAQAPGHVAQPSGSILSRRSPLSASVPIATSLVPPTPSALHRPGYSGEKSAFLAPFETFYDALADSKQLKNWLGEQLQKSQNLTASLQRQQDQLDEMVNKAVEKKALAMREEIYGLHRRVEDLELALHVARGGHSVHSPGSTSAQGKGTLNGASSVPVAPESYTFPPVNPLAKVPEFTRRAPSPEPPERDGRSGTHSFPGSLAPSPIPFDVSKRVSVSAMRLDPRSPAAVSAEVSSSSRKLPSGSNLHSHNHSQGERSELQAPSFSIPFRYITAGERTSSRDSKAIPSSSNLHRRTSSQRVAAEAGGDERSEGSVAASHRESVRYGSPRNRGLSPLDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM04</accession>
    <name>A0A401GM04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0502910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614156.1">
        <property type="nucleotide sequence ID" value="XM_027758355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM04"/>
    <dbReference type="FunCoup" id="A0A401GM04">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GM04"/>
    <dbReference type="GeneID" id="38780160"/>
    <dbReference type="InParanoid" id="A0A401GM04"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="143"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35313" checksum="90FE0D9A2BABC0FC" modified="2019-05-08" version="1">MSWFTSKFTRRAPTPAQGLYAPPPGPPPHWQPAPERSHTFGLLNEATKDEYEAALDFCARNAPEPPRLLPSHIVDRIDAEGCRTWTLQWPRSPRFVGNTQNSSEKGGSSVVKVVTEKSCMDVCLLSDLPLLAGLYDIQGKSGVYYEILIHKMDGIIAVGTTCRPHPEWRLPGWDRLNVGLHLDDFRKFFEDPYGVRDYTDRLKHITPGDTIGCGYQFSNSGVFFTHNGVRLRDAFTGVYLPRAQHDVYAAIGVEGANNFDVNFGGDLFRWKEGNEWAWRVEGHVGHLSSGDFVDHDDQLPSYEEVRGGPANNLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMN0</accession>
    <name>A0A401GMN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0504890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614353.1">
        <property type="nucleotide sequence ID" value="XM_027758552.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMN0"/>
    <dbReference type="GeneID" id="38780357"/>
    <dbReference type="InParanoid" id="A0A401GMN0"/>
    <dbReference type="OrthoDB" id="3271284at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1359"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="908"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1269"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1388"/>
            <end position="1402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1402" mass="150065" checksum="83470C5F5FE67663" modified="2019-05-08" version="1">MLYSMFNRRKGQKKTTNFTTVKRAQSPPSPASFVSPEIVDIHEKVSVDAHAHAQSNGFNSSRASTPRVQLDLDHHSMSISDWFPQGMLGSEIRSPPERNVSLPGGSGGSGHGHGTVSSSRNASRTREISPPSPVDDVIVIKPTKPEPEQAEPFTITSVMDADAHSTQSITSTSDGTPSRKPTPIRIPDNPAAAKVQVQHPASEGVSASQTSNLALPGSNVSTRPPTPGSAYTEEISSAISGTTLARALVANSFIFTADTRASRYRNGVTRQDSAILPRGDHALMHSPSDRRASSSTDIHSPERPPSVPPVPPLPPSADTCGSLDSAGSAGRIRKNSVAAPESRRGSAEFSHALEVLRGHKDQPSAVPPISPITEAPSPAPSVPNTPSIWDGVSHTSNRSSQKPPSIRCSVHTKDDDVVPPSPLVEQEHVSTEPPASSTVSSDSGPSERVAHRRSKFMLDLTVEGATFSSPQPLPALPTTTTGSSYSANSFEKQGTSTAGTSLKTSVSGSNAKSPSVTRSRSDSGLRNYNAPYRPVVLLPIGERPRSVQVPHSPISSPVSTRTPSDTDLRARMYLGAGVPISATARHIGETPVDSPDLLDFMFPVAPTNLTYERSGSHLAPLAISPQDQQSSLRNSSVESLIAGSASRQTFPETPYAFSPLWSAGVASPIPPPPARPGMEHARSLPRTNRGGVLMRFTQRNPLSRSTSFGGASPPRHPPLSTEIIQRKSSESDPGTTGSSEYSHEQPQARLSRIEESRSPSNPPSHSPSPEPSLASGRSGRAPSDGAHTREGGCTSASFLHASSARGSMAMAESRSPLRSPLPPLPVPAARTPPTTPLPAVPAIEYPLGSPPPFYAPSEEPSSTIATLEVRLQAETDNGVPERLSMPPVRAASPQLSSLLPRKRALSPLPSPPPSGVPSPQPPSPRSVVGTQQTPDHAPPSYVDDMRRPSPPDTPPSRLTAILVSNRAVTPDLGTPTTTSKRTPRTRPPLPLGPRKPSNSTASSLFSGRSRNGSVSSTTNLSSHHPMRRPSAATLSASLPRFQRTAAKFKGLTMEQAQWTFTSQQLQEVVSSAIKQTVDPSAIRLLPLDTLNHGVADEIHRLEALSAELKNEYRLNARRRRMLMSSLTSTMDSLEHPDTPAIYRMLDELSDLDETLDQLAEELYNATDQLSQLNLLREMHKSSALAMALRKLNTKVVQQIAESQKLREQMAALEAERDDAWKQAQEIAREFDDMTDKTAAPAREESVSRRSSRVLVARKNSTRKAELRSSLHTRSQRSSTSDAHRNSTAGSPGVRSAPIEEIPPVPRLPIRTPLGIMTDVPSGHSTADLMSDSASSGLRALTEAQRELCEILGISLEELRPSRPQSMSTFEGRGVSPRKRRNSEVLATKQRTPGSAQATFRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMU3</accession>
    <name>A0A401GMU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0505630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614425.1">
        <property type="nucleotide sequence ID" value="XM_027758624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMU3"/>
    <dbReference type="GeneID" id="38780429"/>
    <dbReference type="InParanoid" id="A0A401GMU3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="85" mass="9235" checksum="8E7D1B442C595462" modified="2019-05-08" version="1">MPQSPSSPLVLMPMPAHRKSSSQKLGQDSRGGSRKHISMQSLVPTSRRASQQQVREREREGECNAGLSLHPYAMVPSPGGYCAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNH1</accession>
    <name>A0A401GNH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0508210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614678.1">
        <property type="nucleotide sequence ID" value="XM_027758877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNH1"/>
    <dbReference type="STRING" id="139825.A0A401GNH1"/>
    <dbReference type="GeneID" id="38780682"/>
    <dbReference type="InParanoid" id="A0A401GNH1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="6">
        <location>
            <begin position="513"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="696" mass="78290" checksum="5E6867916DB4D3E1" modified="2019-05-08" version="1">MAKPQKLVAIIGGGESGLVAYRHMIHYPNLKPTLFEASSSLGGIWSTDHPYHRPLMTTNICRHTCLYSDVPWPADAGPKRKDLFRYSGDMGNFLNVYAQRYLRDGDVRMNTKVTKVDLRDGKWALNSTVVHDGNETPQPEEAFDYLITATGFFSNPYIPALPGLDASPFPVEHSAVFRDPDAYRGKSVAVVGGSLSAVEIAGALSPYAAKIHHITPAPFYVNPLFVPTTSENSEIPRFAPWDLDSYRRAYLDGRRRELINPTPEDNRKKHSYFASLFPKNILPNFNFDTSTPPQVGFSELYRGGIQTNVVKTYLARLESIDPEAGALVLSNGERIYSPDFVILCTGYSVSFPYLTPSALEAISYQHDNHSVPFLTHRLVLHPDLPKAGFVGVYRGSYYGVIEIQARYLAAIFSGEKSWPSEEEMRKGVEIEKSVREAARQTGIQFPHGDYAGLFESYAALLDIPYSDEDHIVAANYPLQENEDVEKIMRDVQHADALSSDGAWIPGAVFRSWAGHWKVNRRVHGAMQKELNGQFEGFAMFHMRPPSALPSGYSTAELGMREYLYHEHGVFVSTSGKKSDLHRKYVYRYSPPSDTISVWGVTSDDYDGPPEQGEVEDWLHDISRVSFRRPGPLQEQDITWFVEHNALEHWEAAATEKEVSKLVYKFVFEGAEVTQFGVGYEVHGPEGRYVSEAWFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP67</accession>
    <name>A0A401GP67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0510190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614873.1">
        <property type="nucleotide sequence ID" value="XM_027759072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP67"/>
    <dbReference type="STRING" id="139825.A0A401GP67"/>
    <dbReference type="GeneID" id="38780877"/>
    <dbReference type="InParanoid" id="A0A401GP67"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="124" mass="14078" checksum="2F5938995FC474AC" modified="2019-05-08" version="1">MLGETLLANPCLFANVVPDPVKISLEYLDLCRALPSTVILQAMQTHVRHFVDHQCGRRPWFNKFRTALNRCQSVDDIERLLRVKVQRWRGVAPFPGDDLEADGLHEVGQPESMDEVLSAISLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP68</accession>
    <name>A0A401GP68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0510650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE84006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614919.1">
        <property type="nucleotide sequence ID" value="XM_027759118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP68"/>
    <dbReference type="STRING" id="139825.A0A401GP68"/>
    <dbReference type="GeneID" id="38780923"/>
    <dbReference type="InParanoid" id="A0A401GP68"/>
    <dbReference type="OrthoDB" id="3271131at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="744" mass="81083" checksum="8C5F1FC09E8A2D11" modified="2019-05-08" version="1">MPSSHQGWSFNLRAYDFSSGSDSDNDGDGTVASTNLSAVAHRSPHDQSSTVSDDAQLLRDIDLSSRTDSAAYKPNPWTIAKVNATSRKHHPVDFSAATCSRAPLAKKKPRGKIVEAFEKQCARRTNVPSQHAQQLAIPRTLPPGEVFQPAVASPPSTSLSDRLPPSSARHRNVASQLSACSAVPTLRSSTFTDTRFNQSDQPIVLRSSVLYTQDASSMVPQTPHTMTRSLAPVTPVSMFRSSAPSVSARKNIPISGAHTPSSNVPSNSHRFPDCLDASVGTQSFVRTVTEEEVFSHLTSIPQTPSHPILSDSVSVTKNPTCKIEEIASTSRLGLTPEEIKTSVSSQTSCYARFLRPGVSPQLLYSPHQTVTRPSSFVLKAEDTESTALPRSVVPATFPDTKSSILGQQSSVGRNGTRSPLRNRPTSRISPTNTRLLHYSDQPSPLHVDSPALIEPRSMLAITSTVSLDANTRTVDHLTPARRAPPSAIPLPAQRLYPTGPSSVISSMHTSISDHSPRATKRLHNAKRDAYTAFPTTPDSGWSTLSSTKRPRNEPSRIGDARKSVRSSGRFRLPPSLLPSRDAIPTRQKLRIVTYRPPPPEERHAACKIIVSDDESDEACTRGISAASGSCELMFKRSGRKLDCMSSDTDCVADHFPKHSPAQKSTSARRSPRHKSFPHMVSRAILPSPPTSDPPLPLLDVNEQQKSSSDDLRMEFRTHNLGQRYSATRRAIAKVCLLSIWNTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP87</accession>
    <name>A0A401GP87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="14">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0510710</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE84012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614925.1">
        <property type="nucleotide sequence ID" value="XM_027759124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP87"/>
    <dbReference type="STRING" id="139825.A0A401GP87"/>
    <dbReference type="GeneID" id="38780929"/>
    <dbReference type="InParanoid" id="A0A401GP87"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019451953" description="alpha-1,2-Mannosidase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE84012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="544" mass="59158" checksum="C86259D670BA7409" modified="2019-05-08" version="1">MGFRLLGSVVLALVTSWSVPGVLGGPVQSPDIVMPSDAAANRQRVVDVFTTSWDAYSKYAYGHDDLSPVSLSYSDSYGGWGATIVDALDTMYIMGLTDLFEQAVNWTTSLDFTVTPTDDEIDLFETTIRYVAASLCAYELSGEKYPALVKQAQALVDKMSNAWVGDNAVPYGYMNWNQSVPVVGTSNIAEAGTLTLEWGTLANFTGNDTYRVLAEKPVRWIANLAPPLPGLPAQGIDPSTGDFVGSYVTWGGGSDSYFEYLIKYARLTNTDDTLFADAWATAVDSSLHNLARTSTVQEWQYLADWDDGTIIHIGSHLECYHAGNWILGGSLLNNATIVNFALDLMDACWNTYASTATGIGPEVFGYFSSDGNYTGSSPSSGDLAFYERHGFFVYPGDSDYYLRPEVLESNFYAWRATGDVRYYENAVSALESFETWLPAPVAYAGIDDVDATDSAFIDDMQSFWFAEVLKYLYLTFSDPSVISLDDYVFNTEAHPFKAPPAKATYGSGNLFVPSGTFAPQAGPLPQVSPAPPVAPSPVPPTPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPX4</accession>
    <name>A0A401GPX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisome biogenesis protein 19-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615123.1">
        <property type="nucleotide sequence ID" value="XM_027759322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPX4"/>
    <dbReference type="STRING" id="139825.A0A401GPX4"/>
    <dbReference type="GeneID" id="38781127"/>
    <dbReference type="InParanoid" id="A0A401GPX4"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="353" mass="37686" checksum="068A0016C2AFA972" modified="2019-05-08" version="1">MPAPPKARVDVDEDVDDLDDVLQQFSQPKPAKAPPAASSAASASTRTTAPAPSTNTNTKANPPLADLPDTDLSEDFARELTRGMESLMREIASEAGLDPDAAKLHAGGTAEGTDADKERQHAFRAAWEAMLLEGMNGAVDFDGLAAETAGKEKEKEKEKGTGTGTKENEKGKDQASVGGEHAPDSFQSSIRRAMEKLKESNSNLQTDASTPDSIEALLSQLKAEGGGGESEDDLQGLLEQMMTELMSKDILYDPLKELHDKFPGYLAENASKISAEDKKRYDSQHAVVTKILAVFDDPTYSDQDVQKGVRIVELMNEMQSYGSPPAEIMGPLPPGLDVGPDGMPKLPEGCTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPZ7</accession>
    <name>A0A401GPZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0602710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615206.1">
        <property type="nucleotide sequence ID" value="XM_027759405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPZ7"/>
    <dbReference type="STRING" id="139825.A0A401GPZ7"/>
    <dbReference type="GeneID" id="38781210"/>
    <dbReference type="InParanoid" id="A0A401GPZ7"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="331"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="574"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="609" mass="69603" checksum="B8B8741E37910BFE" modified="2019-05-08" version="1">MSQQRKALWEAELDEDLQDVDLSLAIGNYGQDGLYDDAQSRIDEVTLLAVQQQMAQQAAFAQIPDVVKRFIVHFHQAVLDNNLAEITVAYESGWNRLTEQFYSKTEWPEAEVIAPLVNDDQIFLILYRELYYRHVYSRLQPDIDDRFHSYENSCELFNYLLNSDGPVSLELPEQWLWDIIDEFIYQYQSFCVWRSKAKSKTDEELILLADASQVWSSYSVLNVLYSLIQKSKINEHIVALQEGKSTEEIAEIVGEYGVRPLYRMLGYFSIIGLLRVHSLLGDFTLALKVMENVELNQKSPFTRVTACHVTTYYYVGFCYIMLRRYPDAIRAFVSILNFILRMRQYHTRSYQYDQINKTADRMYALFAICNALSPTRLDDNISNIVKERYGEQFSKMSRGEEGIPAFEELFLYACPKFISANPPPYEDSELIAAYIEDPPVEPAQRHLALFLSEVRAQAPVPTLRSFLKLYTSLDAKKLANFLDADEEEMVQQMMVMKQASRSVSRVEHEKGLLDGQTISTSDLDFVINENMVHIAESTVGRRYAGWFIRNTEHAQRVFDMLRNSPLPAPPPKPVQAAAANGAAEPPATPAPSAPRTGGQKVAWGGVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ05</accession>
    <name>A0A401GQ05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0602760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615211.1">
        <property type="nucleotide sequence ID" value="XM_027759410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ05"/>
    <dbReference type="GeneID" id="38781215"/>
    <dbReference type="InParanoid" id="A0A401GQ05"/>
    <dbReference type="OrthoDB" id="3261852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="272" mass="30079" checksum="08A0A4C9B9448C1C" modified="2019-05-08" version="1">MPPSQAPKDTPEQHYPHASLTMPPPLPANDLQVVSIDSLEAALAKLAIKISVNDIVSVIREEEEAKRVKLIARASERRATLSNLALNPLEQPSGLQFTTTSKFIADPPKPAKADPLAKERRRRLLDLTEQTFPDGKVPDPVVTSAEDQTDNPPQSVFENVWCLWDTGAQTSFVVTHLLDSVVRNNQDEGSAIMEISFQGVNQRVDSIIHFRPTLPNGVTFIILGQHALLNRLQYQIQPTSICPQLSQIFPQAYGQIDLVSWCDPLGDEVVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSV4</accession>
    <name>A0A401GSV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0705050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616231.1">
        <property type="nucleotide sequence ID" value="XM_027760430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSV4"/>
    <dbReference type="STRING" id="139825.A0A401GSV4"/>
    <dbReference type="GeneID" id="38782235"/>
    <dbReference type="InParanoid" id="A0A401GSV4"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE85318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="225" mass="25430" checksum="4CFB9C6775FCD5F1" modified="2019-05-08" version="1">MQATPRASHHDVWPLPGRHGRYLLYKAGEIANTDDTLFADVWANTVDSSLHNLVWGWQYVADWDNGAIIHIGPHLECYNAGNWILGGSLLNNVTIVNFALDLVDACWNMYVSTVHGPEVFRYFSSDGNYMGSSPSSVNFMFHERLGFFVYPGDSDYYLRPEVLESKFYVWRATGAVRYYENAVSTLKKFETWLPAPITYAGIDDVDATDSAFIDDMQMALVELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT89</accession>
    <name>A0A401GT89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0705760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616302.1">
        <property type="nucleotide sequence ID" value="XM_027760501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT89"/>
    <dbReference type="GeneID" id="38782306"/>
    <dbReference type="InParanoid" id="A0A401GT89"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="249" mass="26905" checksum="8418905BF5FFA3FA" modified="2019-05-08" version="1">MLSSTSSHTEEESLLEPENLSSPGIHIPPVFCAFLETFEASSQYSSPEDPTMHHYHSCLLELSRVCELLAFKLADQTHNLNTLGLLYSVEISKGISLLQSILPPAFNQLTELQSGINREHAVGVVLAAEEHAPARENIVAVAEGDNVAAVAEGDIVAEKDLIPQVDAVAKEDSIEEEETKAIALAPILHLLPATPPRPSGWFTPVPTSCPEEIELCISAHSTPSASSPFTVIPTSDPLEQTLTFFDYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTP3</accession>
    <name>A0A401GTP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616514.1">
        <property type="nucleotide sequence ID" value="XM_027760713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTP3"/>
    <dbReference type="STRING" id="139825.A0A401GTP3"/>
    <dbReference type="GeneID" id="38782518"/>
    <dbReference type="InParanoid" id="A0A401GTP3"/>
    <dbReference type="OrthoDB" id="2790555at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="317" mass="35762" checksum="322E0381EA609744" modified="2019-05-08" version="1">MSRDIHQFVSADWEPEFANETWDPPPHMRTDLTRLEGPTIPIIGRHFYRVPDARLLKVGGSEGEARMTVLARRVLEGTLTISTVHAFIQIPDSGSAILSDRVQGVPLSTLWNDISASQRTTIKNQLCDVLLAMRKPSFEYAGRPGRRPYVLPTVLASSAYDFCSDLEAWNESRARAIVGNVADARRAESLREQQYKLVVTDRFVLTHGDPSDRNIIVEPDTLNIVGLLDWEDANVVPSYFEYVAARLSSGHLPYWRVELLEVLEKVLERGCGETTNVEEEFARWKALVDVERYAQGLDDDCAWTFEPDADDRGIPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTY7</accession>
    <name>A0A401GTY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0801990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616590.1">
        <property type="nucleotide sequence ID" value="XM_027760789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTY7"/>
    <dbReference type="GeneID" id="38782594"/>
    <dbReference type="InParanoid" id="A0A401GTY7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="26632" checksum="A05441F0CCB145AA" modified="2019-05-08" version="1">MTWEFMQTLTNINESTIVHTTSACGSYHTTNTRLGLTEHSPIISLIPQFPPLHPTNLLQDSQPMASYTSELTVHAPTPAPSPALMIGKRRRCTAEETHLVQATAPPAKKQRKYTRKAHVTKKRKGKGKDEEISDDVRFPDGGSPSCERCGRQHGRIKSWCDPVNASGSFPGAACECMMEGMLKPLEPMNLHNRPSVPRDTPLAAPIFAPAPNDVSTSKKGPKRTSTVAPFGEDASRPTKRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTY9</accession>
    <name>A0A401GTY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cephamycin export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0802100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616601.1">
        <property type="nucleotide sequence ID" value="XM_027760800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTY9"/>
    <dbReference type="STRING" id="139825.A0A401GTY9"/>
    <dbReference type="GeneID" id="38782605"/>
    <dbReference type="InParanoid" id="A0A401GTY9"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17321">
        <property type="entry name" value="MFS_MMR_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="521" mass="56504" checksum="57939A432B9A9C57" modified="2019-05-08" version="1">MLSGPSSNVLSPAQTLVDGRVPPKYSTFRRYFLLLIYCCAQFLDAVNNCALYSAIPSLVISLNISESQSTWIISAFQLTFASFLLISGRVSDVYSPKLVFTAGIAALGAISIGAGFVHDKITLIILRALPTEQARAIGIFGGCGAVGNVLGLIIGAIFVEFASWHWVFWFVALVAFPIAGISLLLVPSPERRLNVEPKAAKWKSLDIGGVSILTVALILFIFSITSGSTDGWASAAVLSPLIISVVMIVTFFYYETRIPFSRAAVPPRTWFLPNFSVLFVTALLPYFWWTTIFMTYTTLWQDVYHWSVISTAIHMIPIGVLSFVMSFSGPLSSVINSKWIIACGEFLLVVATILLAFADGPDKYWRFVFPGFVLGSGGAMLTFTHTNIAIFQTCPPSFSGTVGAIFNAALQLGSAIGIAAVGSIQTSVQAKHGGPDSYSGAQAAFWFLLGIVCVELVSMLIFYHTKTRRVDVLPEKIQEDTKGELDFHDKAVDNKLAVADTEEPANEVEVLNVDELAISPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU50</accession>
    <name>A0A401GU50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0704410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616167.1">
        <property type="nucleotide sequence ID" value="XM_027760366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU50"/>
    <dbReference type="GeneID" id="38782171"/>
    <dbReference type="InParanoid" id="A0A401GU50"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="214" mass="22952" checksum="4C7F790A8DDCA9E8" modified="2019-05-08" version="1">MEVLSDCLQVSVVKKAPHTDEHAINGGRSVRTDPTCGFQQQPANFFPIFNGPLQFPNSRTEPLGNQRLPQVVGVEESDVYPRAWAAMIKRRAVQVLLPGAAIAAFLVLVRERGWVPFFVAPTPTPAPATFECVFMSGETVSYPMGMRPLSSFLSNASPQSSRPSVFELSTSVSNAGPPPAPPASPLVSRSLSNRSSRGSAFTYASAASISDFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUB6</accession>
    <name>A0A401GUB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0803180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616709.1">
        <property type="nucleotide sequence ID" value="XM_027760908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUB6"/>
    <dbReference type="FunCoup" id="A0A401GUB6">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUB6"/>
    <dbReference type="GeneID" id="38782713"/>
    <dbReference type="InParanoid" id="A0A401GUB6"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000792">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="134"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="13">
        <location>
            <begin position="1179"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="685"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="798"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="885"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="808"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1070"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE85796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1228" mass="135050" checksum="18DA0457160C8D46" modified="2019-05-08" version="1">MAAYPASLAYPPLPQVSEEGTLTPSHGGMVTGHEFDVPILQKSPPSAAPFNLSQAAQEQTQLPNSPTTSQAPVPRRPASTQKPRPLSMPPQTFAAPSPSERDRHFAEDGGRHVQRGDATPQGKPRSSNRILGDYTLSKTLGAGSMGKVKLAHHNLTGEKLAVKILPRANPPSGSVMNSDAAAKQASRDASKEIRTIREASLSMLLHHPYICGMREMIVHPHHYYMVFEYVNGGQMLDYIISHGRLRERVARKFARQIGSALDYCHRNNVVHRDLKIENILISQTGNIKIIDFGLSNLFDPVNHLSTFCGSLYFAAPELLNAKVYTGPEVDVWSFGVVLYVLVCGKVPFDDQSMPALHAKIKRGLVEYPVWLSAECKHILMRMLVTNPAARAPLSEVLNHPWMVRGFRGPPDSHLVHREPLRVDELDGQVIRGMKGFEFGTEDEIERKLVEVLESDGYYRAVQHWERKRMAMNGRNGRHWGESLSSSSIALDSGPNGKNDFTPSKGRKRFSGFDFYRRKLFSPTSSPPDTPFHSPPTSQSHLSRTSLTDASQREPPDPTYGFHPLISMYFLAREKMEREKVYGPGHFANSQLSLESNNHAEPPHEEHAPAAAKPFSQPALRKKEAVATTKPDYSMLLPRLPAPETSHYSGMSYDATGPTLSPATPTFAQPRARDAALTLLKPADNIQTTTSVPSSPTRAPMPRAPPASTHRRSHSLSQRPSVSRGWTGMFGHSGTEAVTEHGTLRARRDPLEPPRTAGPELTSFAERMEPERLEEEPRTPVLVSAGATLVRKFGSLLGGGAKTEESRRTSGQSKRGSILTGTGFTPRPSTEKEEKVEEPTFVHEKKSLDNPPNGTPTPTVAVTHSQSQPIGTAHRRAATILDPQSRSMRHERRNSTGAALLSGPGGTIGRHRRPSTGYPGTYQRPFTDRLFGRTDEEDEMAEQEQSEVASPGANGVETMIKEDDDHGGEEKDFKPVYLKGLFSVATTSTKPPSAIKADIKRVLDRMQVQYRETKTGFECIHMPSIDLSSIQSPRPFERQHRKRVSIGSHETDTTRKSIVKRPSKISFGTKASKEKDREAKDKELPSRPSGGTILSATASSASSSFFHVSSSAHSATVEAARSDTLEAISGPPDESPSRSQSPAKGKILPPLPRDFAASPQPTTMTPIPTGEVGQDIFESIGSSSLAVRFEINIVKVPWLPLHGIQFRRAGGDGWQYHMLARRVLTELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUC0</accession>
    <name>A0A401GUC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0803430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616734.1">
        <property type="nucleotide sequence ID" value="XM_027760933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUC0"/>
    <dbReference type="STRING" id="139825.A0A401GUC0"/>
    <dbReference type="GeneID" id="38782738"/>
    <dbReference type="InParanoid" id="A0A401GUC0"/>
    <dbReference type="OrthoDB" id="2745780at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43726" checksum="0D99E0C469347ADF" modified="2019-05-08" version="1">MIPQLAPDIHEMIIDNLHDDKRTLSSCTLVSPSWTYSSRRYLFETIKVSGVVDEFEPFVKYLQESPHISTLIRHLRLLGNSSRRTFLCLHVLVDILSNLPRLRRLDLEEIWSTSSSCTCRSSKSISNSCFSVKQLSINTVIFTTLENVISFFSLYSVVEHLHVNSVSMRDWGDADPDYLNTLAQGFSGDFGVQSLQLRASFGDATFMQFFCDILRYAPSRHTLHSIRAEFLDWDDVATLGRLLQAIGPTIRHLAFDGLNELEKFDLPMQWHDLNLSSCSHLQSVFLVVVVSDIYDDLHDPFNYPLAMIRMMPRTVQNITFQLLSTVVHVKKNCENMDNYDWPIIAQLAFCRPWLSQPPCCHRGEATRVMHPGPSTFLSFAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUK7</accession>
    <name>A0A401GUK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0706010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616327.1">
        <property type="nucleotide sequence ID" value="XM_027760526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUK7"/>
    <dbReference type="GeneID" id="38782331"/>
    <dbReference type="InParanoid" id="A0A401GUK7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24350" checksum="8CC61C4026A26121" modified="2019-05-08" version="1">MFDVTLRQPFLPVTKPTSVRLPPLNNLSISFRVSDTLLSSLFDWLRALPRSSLRRLAVRPPKELSLTIGEAIESFAARLDSLDLTLDDSYTLTDMERLNLHRCTGLRTLSIWHQCSIPLAEILDLVAPSSRIHQLRLHVRVSQPEPEWVRVRNVLASERFCQLQEVVFLLPPDEDDRLGPQKQRTVMGAVEDLRHRDVSVRVSNWSPPFRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVC6</accession>
    <name>A0A401GVC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617052.1">
        <property type="nucleotide sequence ID" value="XM_027761251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVC6"/>
    <dbReference type="GeneID" id="38783056"/>
    <dbReference type="InParanoid" id="A0A401GVC6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8845" checksum="B28920EB0246E91E" modified="2019-05-08" version="1">MALGRLLRAAGPTLSRLTFGVINTEKADDPHRIHQEGWPAFNLWACTNLQSLAIPMHLQYDDGHNVDKSPFESALDFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWJ4</accession>
    <name>A0A401GWJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0904490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617483.1">
        <property type="nucleotide sequence ID" value="XM_027761682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWJ4"/>
    <dbReference type="FunCoup" id="A0A401GWJ4">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWJ4"/>
    <dbReference type="GeneID" id="38783487"/>
    <dbReference type="InParanoid" id="A0A401GWJ4"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="169" mass="18508" checksum="B468E7815A8596C4" modified="2019-05-08" version="1">MSTSYQEAAQSTGYYPLTPAPTAPRPSQASPDSQGASTSAAQPQSSRQVTEEARKDRSLAEFLLMLDDYEPLVPNEVTDYYLQRVGFECEDVRLKRLLSLAAQKFVSDIAADAYQHARIRANTAGGRARTTQSGPASARDKTKTTLAMEDLSAALAEYGITSRKPEFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWU5</accession>
    <name>A0A401GWU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0905710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617604.1">
        <property type="nucleotide sequence ID" value="XM_027761803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWU5"/>
    <dbReference type="STRING" id="139825.A0A401GWU5"/>
    <dbReference type="GeneID" id="38783608"/>
    <dbReference type="InParanoid" id="A0A401GWU5"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019165620" evidence="5">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="79"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="465" mass="51488" checksum="C123F28F2190F577" modified="2019-05-08" version="1">MRSFFGLAVLLASLHYVCAGLPNKIYGVNIGGWLVLEPWMLPAEWLEMGGEICSDCSQCIGSEYAYVKAYPDSADEAFAQHWSTWFTQSEVATLASYGINTVRIPLGYWIVEQLVDRETEFYARGGIMYLQQGLKWLQDAGIQVILDHHALPGVQTSDQSFAGNCTYNVQFYTEYNYHRALVWTAVMTTLSHLDPNFGSVLAIEAVNEPIMDASETPGYGTFQQYFVDTVRAVELILGIPVPGLALDTPVGTTNMSAALVQVGNSSSMVFNEEVKSALVEAAPILAELAVQLSVPAIFDFASASNQREALWTTFMDVNWQRDDPPNPAYAAKGPQGYDNHLYYNFGGVADPNPTAYMESICNLQRVQADAALGDSPLWFGEWGLPTQFNATDQFLYQWADAQKLAYSVGKGWIFWNFQVEISELAGNLSRQWSYIEGVKLGYFTQDPAEYHNASVCAPYISASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXY0</accession>
    <name>A0A401GXY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1002990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617965.1">
        <property type="nucleotide sequence ID" value="XM_027762164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXY0"/>
    <dbReference type="FunCoup" id="A0A401GXY0">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXY0"/>
    <dbReference type="GeneID" id="38783969"/>
    <dbReference type="InParanoid" id="A0A401GXY0"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="84"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="404"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="446"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="486"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="650" mass="71072" checksum="D70D09EF890C330B" modified="2019-05-08" version="1">MEEDVLSTLYMPIVSPPTPAPSPRPAFASLSLGPSLSDPVYPCRREFASLTPSLRRQYLSAILTECSPSELLFVSTTIAPLLKRDFLHDLPPEIALHVLSFVDDPKTLARASQVSKYWNYLLDDSWLWRRMCVTHGFETDNESQSPGRMLRGASEALASSSKRAVYYPTNTVLPFALRSHSFDSAFSYRQHFKYAYVTNTNWLHGGRLLRSHRVPLLSPTQQPTAQPAPNVPGVPALSSAIPTSVAVDANWVVVGLANSRIHVFSAKTGVLSRTLVGHESGVWAVALIKGGGAHGGAGGDGADVEEAVSSGEEDLHDAPPGPDQYVPHTLRFALGLDQVHPRRRSSSQAIHGRPSMWQPWQDKPSDPSGASDGWGQPNALVVSGGCDKELRVWDVKSGYCIYVLRGHTSTIRCLKMLHGRPLAVSGSRDRTVRVWDVQRGTQVRVFSGHEQSVRCLDVCGSRVVSGSYDCTCRLWDVDTGECLHVLRGHFHQIYSVAFDGVRIASGGLDTTVRVWDAKTGTCLALLQGHTALVCQLQLSPTMLATGGSDGRVITFSLESSFSVVQRLAAHDSSVTGLQLDERFLVTSGNDGRVRLFQFGAGGRCEYVRELSEPSESVWKVAYTRETCAIMCKRAGKTVMEIWSFKPKADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXZ6</accession>
    <name>A0A401GXZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1002750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617942.1">
        <property type="nucleotide sequence ID" value="XM_027762141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXZ6"/>
    <dbReference type="FunCoup" id="A0A401GXZ6">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXZ6"/>
    <dbReference type="GeneID" id="38783946"/>
    <dbReference type="InParanoid" id="A0A401GXZ6"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="22"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="483" mass="54656" checksum="038FD4BAB75C60F9" modified="2019-05-08" version="1">MYQAPYPPYDPTDKNSFAYETVLKRWPIILTNVIDNIYLHDHDLSIALTAGDVPAADVARVEAQIAEGKTIIERIGKLKYEMARDRALEPIPDDGEALVDTYNTELARLAGEGKGTWFTVPWLYAECYLYRLMRSYFVQTTYWRAHDPFLASKQDTFRASSRAIFQLATTMHEFERDKDTLDADPANLNILFKEMIQMCLWGNATDLSMLTHITHEDIQHLQSVGRDAQAARKEFILKDDQDKVWEHLTSLGKNAGTRVDFILDNAGFELFTDFVFADFLVTYTPYVSKVVFHPKLIPWFVSDVTPPDFASTITSLLSPTFFPPSNAAPSGLSDARAHLREMVERWAAYLDSGVFELAVLRETPLGASNVKADFWTSPWPYWNMQELAPEVFEGLKHSGLVIFKGDLNFRKLTGDVQWPASTPFETAVGPLAGAFPILTLRTNKADVVVAVDDEVAARLDASGERWRFNGKYALVLFLPKTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY98</accession>
    <name>A0A401GY98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1004180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618084.1">
        <property type="nucleotide sequence ID" value="XM_027762283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY98"/>
    <dbReference type="STRING" id="139825.A0A401GY98"/>
    <dbReference type="GeneID" id="38784088"/>
    <dbReference type="InParanoid" id="A0A401GY98"/>
    <dbReference type="OrthoDB" id="3047765at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="638" mass="69285" checksum="2AA3E035421106FC" modified="2019-05-08" version="1">MSQTTTTTEQGLTVEASRAKRLERQQSRFRDRGGIFVPSTHNALLDILLARGVNGESPAKALSQTIPVEQHDPLPLAGNASKAARRKSHAVRDSEGTDDEVEVATTPKRVTAKRTARARAKAPTKTRAKAKPKAAVRAPPEAHAKGVDAREVNDTSGEGSSRAVEPLAHPPKKRARKVTQQDEKDKDLAEYEAKPRSTRRTIKSTTTRTTRGTAATAYNDTADVLTKIRTKRPSPIPDEDAAVTSDDEPLARRRAKAAPKAKPSRKKKVEEDEMEEDGESAAKKWTAKHKGKAKAPAEVLETATAEVSDEPALVQQDGVACKPSRTRAKSVKDSTKDGKRSTRRTVDCDDADVITHPLKEKLSELRPTKSSTASRTRKTALQCSADTTHTEAPTAAQTEGVQKSRSRAPSSSKASHPTGNEPAESSDDDVPLAALLKRRAKHTKAASEHTTLQPRKQTKGDSDNSFHPTTVSEPKKVRSQDDNSEQIASGLGSRDQLVNAAGTRMAGPSHNGHTALKKRSRDDWNISEEQGDQVECERTRPAKRANVSKSTSDASWKAKLPLTRTVRVGTSSPKAQLAKQKATAKPKRYDKENCRAAAPSAHKSLPRRLKPKPKPRLSLFPPPAHIADSDDDPIDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYF8</accession>
    <name>A0A401GYF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="13">Aconitase</shortName>
            <ecNumber evidence="13">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_1000860</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617757.1">
        <property type="nucleotide sequence ID" value="XM_027761956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYF8"/>
    <dbReference type="FunCoup" id="A0A401GYF8">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYF8"/>
    <dbReference type="GeneID" id="38783761"/>
    <dbReference type="InParanoid" id="A0A401GYF8"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="70"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="586"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE86844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="785" mass="84227" checksum="AC920DFDEC3A58B9" modified="2019-05-08" version="1">MFNLSTRSATAWRSLQRLAAGMATVSEGNIGATKVAMSLLEPNAYINYQRIEDNLSVVRDRLKRPLTLSEKIVYGHLDDPVNQDLVRGTSYLKLRPDRVACQDATAQMAILQFMSAGMDTAAVPTTVHCDHLIEAQVGGVKDLARAINTNKEVYDFLATATAKYGLGFWKPGSGIIHQIILENYAFPGGLMIGTDSHTPNAGGLGMVACGVGGADAVDVMADLPWELKCPNVIGVNLTGKISGWTTPKDVILKVAGILTVKGGTGAIVEYKGPGVESLSCTGMATICNMGAEIGATTSLFPFNHRMASYLDATKRSDIASYAQKFAHNLRADEGAEYDQVIDINLSELEPHINGPFTPDLATPISKFKSAVEKNGWPAELKVALIGSCTNSSYEDMSRAASIAREAASHGLETKSKFTVTPGSEQVRATIERDGQIGAFEDVGGLLLANACGPCIGQWDRRDVKKGEVNSILTSYNRNFTGRNDANPATHAFVASPDIVTALAFAGDLRFNPLTDSLTGSDGKPFKFSDPTGNELPPKGYDPGQDTFQPPPSDRVSVQVAVDTESDRLQLLKPFAPWDGKNPEDLPILIKVKGKCTTDHISAGGPWLKYRGHLENISQNCLIGAINAENGEANKVKNQITGEYGGVPQTAAYYRDHGIKWVVIGDSNYGEGSSREHAALEPRFLGGLAVITRSFARIHETNLKKQGMLALTFVNAADYDKVRPTDKVAILGLESFAPGKNLTLVLKHEDGSKEEIALAHSFNEGQIGWFKAGSALNLMAAKAKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYM6</accession>
    <name>A0A401GYM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1005060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618172.1">
        <property type="nucleotide sequence ID" value="XM_027762371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYM6"/>
    <dbReference type="GeneID" id="38784176"/>
    <dbReference type="InParanoid" id="A0A401GYM6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="470" mass="49049" checksum="CA8BE8B90AF3F20D" modified="2019-05-08" version="1">MFSTPYPHAASMHGMWPLSDSHPTVDNSNNVASDLFGTIGYAAEPLNLPLGGTEVDIDPWWHSQSHNKSESTLSDETLELLWGPEPEKVPDFVPFPDFAPAFDFDPAEFVATASPTLISSPSMFFSAPEPVPYPGHNAPTPPAHPLLPMATVVSGPLPSTVPSLPLLAAPAPVSPITSTRGSAPTTGKRTKRALSDSDSAESSQTTARPAKKARKSKAVVEATDAAATDNDYASPTARTLLHIMQGFATKHWSPAHEVIDLTIDEDHPTVLKTTRELGEFTKRVLAESVPKGARGGRVCGPAKFAVAPTPAAVPESRAVSSVTAATGCKSRATATASSDGRQDAVPAAKRKTRAPRKKRIAGVANKGKAVEGKDGSPHATKGTVTTSSSNVRAKGKRPARIMGPPTIPPPVIAAPVDFIHRPRSSTSASSAAGSARSSNGSAASAPVKSTLAIPMPVVASKVMFDIFSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYM8</accession>
    <name>A0A401GYM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1005080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618174.1">
        <property type="nucleotide sequence ID" value="XM_027762373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYM8"/>
    <dbReference type="STRING" id="139825.A0A401GYM8"/>
    <dbReference type="GeneID" id="38784178"/>
    <dbReference type="InParanoid" id="A0A401GYM8"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="301"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="383" mass="42889" checksum="9E169E781739183F" modified="2019-05-08" version="1">MSTSAQTAMLVPLDVQAVETESLLFDSFLRVYDSLLNGSDQTLSTLSEKEVEAIRELYGKLSKLPLRDSLAALWCLRDARLVHDSLSYSRTRAIVERFTTASRDSPALSLPDVYTQPREWSPDVHTNLPSPEEVFNAPVLSEQGGSIVAKVTETLVVKYGQSISLREVAAILYVSAYTSVPVPQIHGIYEYKSELFLFMDFIPGRTLEDAWPDMTAASKDALTEQLRVHMNSLRLLRGTYIGGLGCTPCFDHIFADEPPSDYGPFPNVAAFHDTLGKVINCYGDLKGFPTSRSKRRLFKDDYRIVFSHGDIAPRNIMVSEEGKLAAILDWETAGFWPEYWEWMKASIDIGLEPDGWGDALNLILEPFDADALIENMFSRVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYZ1</accession>
    <name>A0A401GYZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1100490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618287.1">
        <property type="nucleotide sequence ID" value="XM_027762486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYZ1"/>
    <dbReference type="GeneID" id="38784291"/>
    <dbReference type="InParanoid" id="A0A401GYZ1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="10684" checksum="C73B7C20CFA20A7F" modified="2019-05-08" version="1">MEWEEMIQLEVNERGHEDEIEQIHWSNDEDEILPMHDDSMLPADNDGDSEDEYWRDDAIPYIPEDLDNPESAHDPHVEEERREGILSMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ59</accession>
    <name>A0A401GZ59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1101200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618357.1">
        <property type="nucleotide sequence ID" value="XM_027762556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ59"/>
    <dbReference type="STRING" id="139825.A0A401GZ59"/>
    <dbReference type="GeneID" id="38784361"/>
    <dbReference type="InParanoid" id="A0A401GZ59"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="71"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="321" mass="37251" checksum="AC80F7E2D0CD195B" modified="2019-05-08" version="1">MSRIVTRWRSLQASRSLKLRIGQTRSLFAWASPKQSDLLPLDRMIEEEKVDDYSPERFYPVQLGEVFRGVYQVAFKLGYGGVSTVWLARDLRRWRWQPDRHVTLKVYRNDTPHRAAAEREIELSRVVAAANPAHNGSLYVRTMLDSFEITGPHGRHYCLVHEPLREPLNIMQRRMASSRYSSVVVKGILYYVLEGLDYLHTQCHMVHTDLKPENILFAFEDISCIDRAVREEADHPSPRKTVVDRTLYQSRINMGPLKTPPEYLRIIDLSHAVRKDESEFFKGFLQVNSYRAPEVLLDIPWSYSVDIWNLVMGSTGGCRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H092</accession>
    <name>A0A401H092_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1200590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618747.1">
        <property type="nucleotide sequence ID" value="XM_027762946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H092"/>
    <dbReference type="STRING" id="139825.A0A401H092"/>
    <dbReference type="GeneID" id="38784751"/>
    <dbReference type="InParanoid" id="A0A401H092"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="594" mass="67047" checksum="766796B5B34411C5" modified="2019-05-08" version="1">MTICLAYQKNISDRRYRAHLGQCRKAYEYTASSIDKYEARGEKEKKAKLRKWDRTQNLDEECAALREVLNEVEDFESAGYAGEANDSMAVPPLIQEDPPDPSTISRAGRRCILPRRLVDYLPSNFGGLAAHILREKIPTKRSQKAHDAGIMDDAPPLPPDPEPAAEEIVPCFQTEPNQFGVYCEYITTPLADPEDEITLDSLCDSPTLITAWSSDSSHWNSLRSFGAAFMKKLHDAEQNYFAPFLNATTYHLISWLYNSSSVKSVADLDCLVNDVLHAEDFDIADLENFRAARELKQLDNYSEAFDAGDDWCEAAVKVHLPKENVLYRSEDDAPEFEVTGIYYRPLLQVIKAAYQDISATRFHVIPHKLFWQPPSSSNDASSSESASSDDDVEVEPEPVRIYSELYNSDAMLEEDAKLRTLPHNPDDSLDVEITIAPIMVWSDSTHLASFGTASLWPIYAYFGSLSKYFRGKLSAFAAHHLAYIPSLPDKIQDYYRSIYKVAAMAATLTFCKHERMQAIWLLLLDPEFMHAYKHGIILLCGDGVLRRLFPQFFTYSADYPEKVLLACIKYLAKCPCPRCLTKKANIGAIGTRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0F5</accession>
    <name>A0A401H0F5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">SCP_1200940</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618782.1">
        <property type="nucleotide sequence ID" value="XM_027762981.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401H0F5">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0F5"/>
    <dbReference type="GeneID" id="38784786"/>
    <dbReference type="InParanoid" id="A0A401H0F5"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="GBE87869.1"/>
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    <evidence type="ECO:0000313" key="30">
        <source>
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        </source>
    </evidence>
    <sequence length="3917" mass="430469" checksum="9F87A6CA0E92B041" modified="2019-05-08" version="1">MVSSTSPTSIPTRPILIQSGQTRFSIPVSTQSDEWIAAEVLRDEFTLSQPAALDTTFDTEEQATLELYARFLGFVAQKLDEDADSSAARTTVLLKILQHFTTSYLSHQDVHTVAASFDTDTREAILAAYFRAVCSLEEKKGGDVPQQPTPALLSAAAQKDASVYAIFGGQGTNEVYFDELQSLYDIYKPYVASFLETVTRDVLVPLASASESTYYAYGLDAISWLTGAAPRPPTAYLATVPVSFPLIGLTQLTQYLIVCRVAKLSPGELCVRLRGATGHSQGLVSAVCISASNTLESFFENAQKALKWLFFCGFRGQQAFPVLALEPSIVEDAVEGGEGVPSPMLSVTGLLLKDLEVHIKKTNVHLPENSQLHISLYNGSKAFVVTGPPRALFGLVNSLRKVRAPSGLDQSKVPFSQRKPVFSVRFLVVGVPFHSHYLEGMTKKMFEEDLEGEELWTKEELAIPVYNTEDGSDLRKLSTSLTCALCDLIFTLPIHWDKATNFPETATHAVDFGPGGLSGIGPLTARNLDGRGVRIIIGGDKTKGVVEMYDAQNVKREEWWSKRFMPGLVKTSDGSIHIDTPFSRLLGKPPIMVAGMTPTTVKAGFVSAVLDAGYHVELAGGGHYNAAALRAKVAEIQSKIPAGVGLTLNSLYINPRQFGFQFPLWQEMRREGLPIEGFCVAAGIPSTEKAAEIIDGLRTAGIKHVSFKPGSVDGIRQVVNIAAAHPDFPVILQWTGGRAGGHHSCEDFHQPIISTYSSIRQHINISLVGGSGFGGADDLWPYLSGDWSVQQYGLQPMPFDGFLFASRVMVAKEAHTSSSVKDLIVAAKGVDDAQWEGTYAKETGGILTVRSELGEPIHKIANRAVKLWKEFDNTVFNLPKEKRAAWLVEHRSEVIAKLNKDFSKPWFGWKKDGSVTEDIADMTYEEVAMRMVRLMYVAKEERWVDLSLRNLTGDWLRRVEERFAGVNGGGEKSSILQSFNSLDKPRAVIEEFFKTYPLATEQLLASEDKAYFLTIVQRPGQKPVPFIPVLDASFEVWFKKDSLWAAEDIEAVFDQDPQRVCILQGPVAVKHSKAKDEPIKEMLDNITSLLVKKLIDRLYGGDVSKIPTVDYLSPGPSALATPLHVERSVSRNTITYKLGQTLPETSSWLETLAGPELCWVRALLTSPTVVQGALYIDNPIRRLFAPRRGQKVVVETDGVSPIGISVYGAARSYGAHKSDFKAVDVKYNAYSHTINVTVYEDCRDVAIPLKLQFVHKPSMGFAPIHEVTTDRNRRIKEFYWKLWLGPEENLPEIDLRATFTGPEVTIDADEIEAFCSVIGNDGEAFKTVRAENVQAPMDFAIVTGWQAIIKAIFPSTIDGDLLKLVHLSNGFRLVDDAKPLQAGDVCKIEARIVSVINSDAGKTVRVKGFVIRDGKPVIEVVSAFLYRGRYSEYDNTFELLEAPDYSVELATEADVGVLQSKEWFEWDDPSKPLQAGTTLVFRVKSEVTYRNKTCYKSVSVSGDIFVRDQIKRLIKVGGVDFLQDDSRGNPVIAYLERHGKPQGLWAPLPNDGYTMTKTGAAVFNSSATNESYSKVSGDFNPIHVNPYFADLAALPATITHGMWSSAATRRYVETVVAQGRPERVVAYDVAFVGMVIPGDSLQVKIKHSGMRDGNIVVKVETFNGKGEKVLEGTAEVAQPKTVYVFTGQGSQEPGMGMDLYNSSPAARSVWDAADAHLTAVYGFSIVQIVKDNPKEKTIHFGGIKGQAIRQRYMDMTYDTMDKDGNVKTLPLFGDINVRTQRYTFSHPSGLLFATQFAQIALVVTERAAFEDMRSKGFVQKDSAFAGHSLGEYSALASIADVLPISSLVDVVFYRGITMQRAVERDAHNRSNYAMCAVNPSRISKTFTDAALREVIDDIAHRTQCLLEIVNYNVEGQQYVCAGELVALQTMTNVLNYLKMEKVDIAKLTEKFTVEQVKEMLGEIINSCFTRAKDQQKAEGYIKLERGFATIPLPGIDVPFHSRYLWAGVMPFRAYLSKKINAAHLNPDTLVGKYVPNLIAKPFQVTKDYVQLIYDQTLSPRLDKVLRKWDTENWGSAEQRQKLAYITLVELLAYQFASPVRWIETQDILFKHYDFERFIEIGPSPTLTGMATRTLKAKYEVQDDSVSRIRAILCHAKHTKEVYYQFEDEAEAAADESAPEAAAIPAPVAVPVAAPVSAAAAVSVEDVPLKAIEILSVVVAQKLKKKVEEIPLSKSIKDLVGGKSTLQNEILGDLQLEFTSAPEKGEELPLEELGSALGVGFSGSLGKYSSGLVSRVVGSKMPGGFNISAIKAYLSKTWGLGPTRADGVLLLSTTMEPPKRLGSDAEAKAWLDTVVTLYAQRSGISLATGAANGGGGGGAGGPTINSEEFLQFQADQEQFAAQQIELYMRYLKRDSRAGEIKYDAEKANVVTLQSKLDAISREHGDTYIDGIQPVFDALKARHFDSSWNWVRQDALLMFYDIIFGRLTTVDREITSRCIAIMNRADPELVTYMQYYIDQCDPNRGDTYKLAKQFGQQLIDNCREVLALPPLYKDVTFPTAPHTEVTAKGDIVYSEVVRENVRKLEAYVEEMASGDTISAPTNIQKIQDDVLKLWNVVKSQPEISEEQKNRIKALYEGVVRSLRKRPESRPRPGAPRPRRSSSQFLRPQVSGVASVTADKVPLLHLKRKVGTNWEYSSNLTGVYLDILHEIATSGTTFKDKNALLTGVGKASIGVEVVKGLLSGGAHVVITTSRYSRATVEYYQGIFQRFGSRGSALTVVPFNQGSKQDVEALIDYIYSTLGLDLDYVLPFAAVPENGRQIDGLDDKSELAHRIMLVNLLRLLGAVKLKKASRQILTRPTQVILPLSPNHGLFGNDGLYSESKISLETLFNRWNSESWGEYLCLAGAVIGWTRGTGLMDATNIVAHDVESHGVRTFSAKEMAFNIMGLMHPLLFSITQVEPIWADLNGGMDRLPDLADITTRIRTDLNKKSELRRAIARDNAADFKMVNGVEAERVLQTVNVVPRANFKFEYPALESYESLADVSKLRGMLDLEKVIVVTGFAEVGPWGSSRTRWEMEARGEFTIEGCIEMAWMMGYIKHFDGRLKDGSLHVGWVDAKSGEPVDDKDVRGRYEKDILSHAGVRLIEPELFRGYDPKKKVFNQEIQLLHDLEPFEAAEVDAQKFKLEHGDNCDIWAGEGGQWFVKFKKGARVFVPKAFKFNRLVAGQIPTGWDAGRYGIPQDIIAQTDRTSLWALVCAAEALNTSGITDPYELYKHMHPSEVGSSIGSGMGGMESLSKMFKDRRDEKEVQNDILQETFINTTAGWVNLLLLSSSGPIKIPVGACATALQSIEIACDTLLSGKAKVMLAGGFDDLSEEGSYEFGNMKATSNAETELAMGREPTEMSRPATTTRAGFMEAQGTGVHVLMNAKTALELGCPIRGIIGFTSTSTDKAGRSVPAPGRGALSIAREVPSKHPLPMLDLVYRSRQLAFRRSQISEWLANEQQQLQEDIEFRKSRNEVVDEEYLASRVADVEKEAARQEKDALATYGMLEGADARVAPLRRALAVFGLTADDIGVLSIHGTGTGANEANETHIWNDVLGAISRTPHNAVPIMAQKSLCGHSKGGSAAWQLAGLLQSVHSGIVPGNRNADNVDADFKQYTYLMFPSKTIHTDGIRAGLMSSFGFGQVGGTCMIINPRYVLGSLEPSAYEAYKGKNLTRAHLSYKAMSEMMINNCLVKVKDAPPYSKDLEAPVLMNPLARACLDPKTGSYAFPAKLNLQPAVDIANVKAISQILAAQGSTAGVGVDQELISAVPSSNPTFVSRNFTDAEIEYCRSQPSPAASFAARWVGKEAVFKSLGVSSKGAAAPMKDIEILKDDSGVPTVILRGDAKSAAEAKGITRVHLSLSHSETVAVAFAQAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0T4</accession>
    <name>A0A401H0T4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1202520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618937.1">
        <property type="nucleotide sequence ID" value="XM_027763136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0T4"/>
    <dbReference type="FunCoup" id="A0A401H0T4">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0T4"/>
    <dbReference type="GeneID" id="38784941"/>
    <dbReference type="InParanoid" id="A0A401H0T4"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000020">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="45"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="340"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="503"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE88024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="760" mass="85086" checksum="E59A963A0971F6F1" modified="2019-05-08" version="1">MNEPRRMFTFTSHLSHSDISQVSLRTDPATETPILHATAEARAKGYDAVCFPLTNDIWKMRWRDLCLLPPGDIQDKEALERRAETWRSKPAFMRDEVTITRIDEAEGVVVMMSDWLELDAPDDWVRHDSEIALQQELAYASYLNVHTAILPPPRHRAHLASYARTVNTCINAIPYIQLSIRIPIYNPMELQFQSTTTDLSTADTSSSLLSSTEPSTATWEMWDTIRSVCGYNPRLTLTLDMTPPMPSVLTVLGQWSAEPVRHIFLPASTFIANAKGYPVLPKGAQSFIRDILKLQPNVILSGTSTGRHERGGEAAYSQYVRHLEKTSPLVQAAQTSGTVENFAQGYQDYLQAPLQPLMDNLQSVTYNTFEQDPVKYKQYEQAIFSALSDWRSREKIVICVAGAGRGPLVARCVAALKRARRDAYIYAIEKNPNAYVTLQERRQREWGDKVQLVFGDMRSVEVPPVDILVSELLGSFGDNELSPECLDGAMRFLKADGISIPASYTAHIAPLSSSKLFHETRVGHEEKATETPYVVMFQAINILSGNGGGISGKCGPQVQECWEFEHPRRDVVLDERGLPFTNSHNIRSAQLTFHIPHAGVLHGLAGYFEAILYRNIGLSIHPDRMHHVSKDMLSWFPIFFPFKEPLYLPTNSELHVSIWRLTNERQVWYEWYAEAFLPMPGTSSAPRYSPMSDRLDSESTPILSPSPLVDAVDIPVIVEEADEVKSTAGATGGSGSSVDLIKIGQTSLHNPRGRSSWIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H122</accession>
    <name>A0A401H122_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1203510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619034.1">
        <property type="nucleotide sequence ID" value="XM_027763233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H122"/>
    <dbReference type="STRING" id="139825.A0A401H122"/>
    <dbReference type="GeneID" id="38785038"/>
    <dbReference type="InParanoid" id="A0A401H122"/>
    <dbReference type="OrthoDB" id="2799409at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="697" mass="79306" checksum="BCAA94982A1FAD91" modified="2019-05-08" version="1">MFIKKAAATGPSSWGELGGMGEGWGVQEVIFNGCEGEKEALGSLPQLYEWNWAHVDTPYLMSEHTTFNDPSSPFGWHSLPYYVDPVSVGFKPEHCQKFRNTTTTWGNNVFVHENWEEHNSWLSNYRPDASVDLVFNYTYAPKETDRMDSLDEAKKYVNASVTQRFYTSFQQHNFSRGGKESGAVIANVQDGSGYNNVSSHHRQLSTVLIGYFHSLRPTRCSTPDRPTFWQKAAVNKTKPRKSRRMKPRNGEPAADMATLQTLRDTGKKDWMQSKSTRNSYDGYIRRGKDFLLELVGKQKASHPGGEGGIGVEDVDGEPVDYEQLQVAFDNPPNQYSALALELFLVEKCFNQNLGESTGNSTYSAFKKYWEMMANETYRGPYAYDKASDHVSGNPAMAARVQDLRHAIENKARSGGGSRNHAEAMTLENMTKLMMWSEQACPSEWTQQEITDLGTMQDVTKHLMMRAFMTSGFTIWTRNIELCSLQRKHYTPDCEGKAPYHIPHDLVKLENRKGWTRKSGGDGALVGNVYEIYEQKKTPEIDMYTHLRHWISFLETHLLNRRLGPEEFIFPTISVNGTVQTQKGIDHDVVQKYLNEFAMAVGLHVEYSTHCFRRGGAQYHFMFCPLGERWSLSTVRWWGGWAEGENVDTLIRYLLDELNTYETTHSDALHPLPREADRSFMGDHILTAPVTAAEIPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1C1</accession>
    <name>A0A401H1C1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Transposon Tf2-6 polyprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_1300060</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619105.1">
        <property type="nucleotide sequence ID" value="XM_027763304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1C1"/>
    <dbReference type="STRING" id="139825.A0A401H1C1"/>
    <dbReference type="GeneID" id="38785109"/>
    <dbReference type="InParanoid" id="A0A401H1C1"/>
    <dbReference type="OrthoDB" id="3205891at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="248"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="804"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="17">
        <location>
            <begin position="1103"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="45"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE88192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1157" mass="132922" checksum="847BBE9C82737882" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGKDAKWPPKPTVEDAPDEEVSIFKEDGLPELITTETSPTSFGHSESIREITADNTEHGELPAVRNDTEPDDPPSEPPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPHDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSQKKDGALRPCQDYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNNLKEHHIRTRHVLQRLKDNDLFLKSEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTALVLLLPDKAKPFIVESDTSKFATGAVLRQADINGDLHPCAYISQTLNPAERNYEIYDRELLGIIRALAEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNRRQARWSLKLSQFDLHLIHVPGTQMIQSDVLSRRNGLDDSESDNEDHVLLPNALFVRSISPTLFNEIRNHAAKDLIVHEALEAIAHKGPFPMKSSPSDWEVRDGVILYKGKIYVPPSETLRRDLVRLHHDSPAMGHPGKFNTLELLRREFWWPGMYTFVYNYVEGCAACQQMKPNTHPTRIPLEPIPADPHALPFSCCTTDFITDLPVSNGFDSIMVMVDHDLTKGVVRTPCLKTITAEGTAKIFHDKVYSRFGLPDRIISDRGPQYASKVFQELNRLLQIRSSMSTAYHPQTDGETERVNQELEIYLRLYCGNNPETWADRLPDLEFCHNTREHSARKMSPFRIMMGYEPRGLPSVFPTTNIPSVESRLDMLQKIRLEALAMHELARQQMVDRVRQGSPKFTLGQEVWLDSRNLKVNYASRKIAPKREGPFEIVEVIGPANYRLKLPKTWRVHSVFHAALLSPYRENDIHGPNYVNPPPDVVDNEEEYEVEAILNHKTYRGHLRYLVKWKGYSSAENLWEPTHNLQNAKRILDAYKRTRRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1L3</accession>
    <name>A0A401H1L3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="2">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1301360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619234.1">
        <property type="nucleotide sequence ID" value="XM_027763433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1L3"/>
    <dbReference type="FunCoup" id="A0A401H1L3">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1L3"/>
    <dbReference type="GeneID" id="38785238"/>
    <dbReference type="InParanoid" id="A0A401H1L3"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="578" mass="65060" checksum="031968669E082AA6" modified="2019-05-08" version="1">MGRYKMDLLTLTDAMALPRPSMSALPTSPVLDLDAAGHLIVVSNRLPVTISKDAGGEYHFKMSSGGLVSALSGCKKTMSFTWIGWPGFFIPPKDRPIVDRRLMDEYSCQAVYLDDDVADRHYNGFSNSILWPLFHYHPGEMNFDEENWLAYRQANMAFAQVILKQLIPGSMVWVQDYHLMLLPMLLRTLIDHVNVSDLDRILDGIELNDVHRTRIHNVKIGFFLHTPFPSSEIYRILPVRREILLGILYSDLIGFHTYDYARHFLSSCTRILGLPTMPNGVEFEGRLAHVGTFPIGIDPSSFIDTLKKESVQKRIRQLERRFDGVKVIVGVDRLDYIKGVPQKLHALELFLTQHPEWIGKIVLAQLAVPSRQDVEEYQNLRATVNELVGRINGRFGTVDFMPIHFMHKSLPFDELCALYAVSDVCLVSSTRDGMNLVSYEYIACQQQRQGVMILSEFAGAAQSLNGSIVVNPWDSQQVADAIFEAVTMDAETRAENHRKLFKYVNKYSAAFWGTSFVREMTKLRTEDAEGPPPPSPQALKSGQAELHIKREDVRGSTIVDGNVPLTPPVNALAPANAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1P1</accession>
    <name>A0A401H1P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619270.1">
        <property type="nucleotide sequence ID" value="XM_027763469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1P1"/>
    <dbReference type="STRING" id="139825.A0A401H1P1"/>
    <dbReference type="GeneID" id="38785274"/>
    <dbReference type="InParanoid" id="A0A401H1P1"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="708" mass="78723" checksum="0D1D6DB2B6ECA7AD" modified="2019-05-08" version="1">MPRTTRSSNAMKQPQGIEVPQRRSAADVQATREQEKQVKAEEKERQKLQREAAKEQQRLEREAAKEKQRLEREAAKEELVRQKVAVKEKQVREREAVKKEQARARLAAKEKQAEEKAAKAQKSHKKPSSEVDDEGSKISESDDKGSLLTDLESGVSENDRPKKKAKKANFKMRTMIKDIRQQPARPAAAEPSDDSSRSEGDDDKTPVKQEVSRGRRRTDLPASGERISSQKNSEPTTGTVKNWATNLSTWGTQPKALSHARSSTSAVARSKPPISFEKELSHSPEPKSKHELNAINLHGYLGNEDEGIERFAALSSPIKGPGNRVTNNDLVKMKDTNADVIELSDEPTPKPRRMRTTQTSMVKIEDVDSDAQRLVKKEKVTKGKARALVEAMVVDSDGEELKHDLKPKIKVAAPESKTSKPNFTNADLPHGAVSGNRWRGTFIPTFARYVGSLEDPWNFDDAEIVRVLQLIWDTVYQSPEVKYTVKKDGPVFSLADQRMSEYRAGFGSSALTHVENFFKQMEDLKCSPHERQIFATTVLTNNCFAFEDTIKLTGLFRSPPILETLAWHYTYIKNAINVPGLYEDDQNIGIVGAVGLSAAAVERILILWMTGDILLHDDGPPTIPLKLNPSTGKKSNYSTNFGDATYGSQTRAYAVSAQNLPVKRMAKLVRLARNIANSTPNPHVVSIASEETSSNNRANLVDAGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1S8</accession>
    <name>A0A401H1S8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1301670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619265.1">
        <property type="nucleotide sequence ID" value="XM_027763464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1S8"/>
    <dbReference type="STRING" id="139825.A0A401H1S8"/>
    <dbReference type="GeneID" id="38785269"/>
    <dbReference type="InParanoid" id="A0A401H1S8"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1022"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1141" mass="126654" checksum="9080420B3A1A664F" modified="2019-05-08" version="1">MNPSQWSHGQLPPPQSHQLQLEQEYDIDPAQFQVLQTDGMQRYERRQAQAQNMAYPTYAQSYPPENSQHAYGYTDPSLNVQQSQNLDALYGANVQYPASSETQTTYQQQYQPTSNAYLSPYSNAVHTYTSSYDSHAPQSTDVHIGQSQSNSRDHLAPISTFQTVRRTSSQQSLYVSPSSTLSMTPYSSHSSSAEPSIDMQAGGLFKDDPSYHPQIPPPTLEQALGAHAMKRARGLIDDFHDSDDAGVEAEGQVEGPHTKADVKPKLPGACKRCKGLKVRCEFITDPDTCKRCKNGGHECVIPGRKKRKPPPKREYLLNQIRDQAEQIKVLIQQLDEANRMVAKRRSLANSGSPLQSTDRTSSLSISPGELTSPDIVTPKEEDEVAPQEVQDWISKARESIEAFGGFINMGGPSVTREMLGDEGSDGSEDSSAEFDVSADGADAEETAFDVGADGEGETFQSFPIPEGMEGHIVGNESFTSDDNGGVAGRGRGRLRNNFSRESTESAPDTTHSGKRGGGATKLAILPSESVPFGLMANLALRKKGKRRSSRDRDAVGAEDSQTEVGLANDNYFRPSAAPERPIIQEAHQPPHILRNGLVSPAEVERLFAIYFDYMNLSVSLLDPVLYTAQKTYWRSPFLFTVICAIASRHYNMRPELYQQAMKYARLAAGTALIGGQKSVEVVEAYILLALYPVPVRRWEEDRCWLYLGLAIRVATDLNLHHPNTPSPDNEMHAREMLNRTRVWLNCFNLDRSTSSQYGKSSIISNSDYTANHSEYWWKCSPFNMDGFDIQLCCYNAELKVMADFRSRIYSDPTHPTGLNKKLDFTKIASDFDDHLSRLWETWIARVRECQTDDPQCHFRTGLLKLAYSYARLTVLAVGFQHGKVTSSNEVPFLWRCLRAATDVVNAVVDDIGIPSQKVYLRHGPEAQSVFVTFASAFLVKLLQPKYTAFITREQRIEIRDHVQRVIDLLGSPEVGIDDRHGPKLYSLFLKGLLATPMARIDHSPGSINRDTFAARRVAQKYQKNQLSSSSSSQSDFGQSASPPPSSGSSLNTNSPQQNPLSVGPYGPQTQPGPTVFQSQYPTISQMSTPEFLAPPLPFDHEMIQSMQSLTDPNIWPDIALPGFNWMGMQTDSGVQGVNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H210</accession>
    <name>A0A401H210_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6570 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1302870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619384.1">
        <property type="nucleotide sequence ID" value="XM_027763583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H210"/>
    <dbReference type="STRING" id="139825.A0A401H210"/>
    <dbReference type="GeneID" id="38785388"/>
    <dbReference type="InParanoid" id="A0A401H210"/>
    <dbReference type="OrthoDB" id="3221862at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046700">
        <property type="entry name" value="DUF6570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20209">
        <property type="entry name" value="DUF6570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6570" evidence="2">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="17861" checksum="2E82550DA3EDDEF2" modified="2019-05-08" version="1">MKPHQRIIATDELQQLNFIEKLIVAHYRHNYFVVQVNMGQRKLSANAVVFPQPVERLHNILPPPREDLDKCLAVLFTGPCKPSPADYKCMPLLVRHTIILNALRWLRLNHCDYEDIQISHSNLASYSEEEPSVYVVHHPSSGSTPAASVASNDNELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H258</accession>
    <name>A0A401H258_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1302950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619392.1">
        <property type="nucleotide sequence ID" value="XM_027763591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H258"/>
    <dbReference type="STRING" id="139825.A0A401H258"/>
    <dbReference type="GeneID" id="38785396"/>
    <dbReference type="InParanoid" id="A0A401H258"/>
    <dbReference type="OrthoDB" id="3040543at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="177"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="353" mass="40833" checksum="4E338AAD52B7B324" modified="2019-05-08" version="1">MLDLNYINPTTLPEQYCEHLPSQVEWSTEQNAHFIGGRPVFIRPDNHNFNYSPEEFERTLPHNLGGIVLQHIADSDIMTSYPGERPDAPWNPPVQNPIPQPTLAPIVPDYIPPMATVTMDEGRHHASQKELGFRKPKIFNSSDRLKLREFINQCKNYIAENSHVYQEDNQKIAFVLSHMQGGMAGSWAQSFIETELTDDDFLSYGSWREFITNVSKAFGDENIKETARTLLRNIKQGTHTADDYIAEFRLLESKVKLEDARNIQYFKWGLNDPLRQRIYGMESMPKTLDKWYECTSQFDNQWRSAQIFKRGATTTTRGKSRSTHRPYYSTSTKDLNAMDVDRINISCLSPDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2V2</accession>
    <name>A0A401H2V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619654.1">
        <property type="nucleotide sequence ID" value="XM_027763853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2V2"/>
    <dbReference type="STRING" id="139825.A0A401H2V2"/>
    <dbReference type="GeneID" id="38785658"/>
    <dbReference type="InParanoid" id="A0A401H2V2"/>
    <dbReference type="OrthoDB" id="3265369at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="340" mass="36816" checksum="44A2380B9178347C" modified="2019-05-08" version="1">MGRPRLEGHITSARLTTRRPAAWLSEHRSLKPWLIPPRLLLISTSTIATRRHLLGCTCLHLLSPSSTPQMAFTIFRDDAPPSEVETSAEVATPSPMRAIAPLNASSLIVFRPDKENIDPLTGLRSNTELSSKKRKTNVLATKIHAPPPSKKAKESKDSKNRVEKTTSAARVRVVADKKRGGSKRVGGAGPSRARRSPSLPRVVEEVDERTDRDGVSQGAINSRCYELTVLPLADISEAYEAVPSLEADLVALVEDVKDVLTKALEVGGTETSRGVSPVPVLKSVSPVRPRESVSTSATPEREGIHSTFTFSSPSPSGKRYAASKRLPKHSSSDAVIEVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Y9</accession>
    <name>A0A401H2Y9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1402110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619719.1">
        <property type="nucleotide sequence ID" value="XM_027763918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Y9"/>
    <dbReference type="GeneID" id="38785723"/>
    <dbReference type="InParanoid" id="A0A401H2Y9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="79" mass="8303" checksum="D600FCF0F7642C61" modified="2019-05-08" version="1">MRFVVSSTTPTNVYALEKCGDNTLGTILRLEATLIMLDLTSYSLDVAFSCAYTGGKREGGISMGPTAVSAPAGFESFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Z8</accession>
    <name>A0A401H2Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1402120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619720.1">
        <property type="nucleotide sequence ID" value="XM_027763919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Z8"/>
    <dbReference type="STRING" id="139825.A0A401H2Z8"/>
    <dbReference type="GeneID" id="38785724"/>
    <dbReference type="InParanoid" id="A0A401H2Z8"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="118"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE88807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="535" mass="59232" checksum="E9838AE3A6E27166" modified="2019-05-08" version="1">MPVHRTRDIPSRPSEVATDAPLPQVAIHSPTPRAFTFPIHNAPYASTSSSPFEPDLKLIVCTPPPLRTFSPTSSIDTDSSSILSSPSAPASQASHKRRRSAASDIGERRPKKGDDDYIKRPENAFILFRRKCCEDRQAQEEADEHAAPVKKQRQADLSKTISQQWKGLSQEDRQYWEDLAKEKKKEHETMYPNYVYRPQRVKKAKKGKARGEHDTDADSNISFVLPVSSPPSSPTRASYGQMRIHGHGRRAASAPTPPPAYQMIQLPQVIMPSCPTSPSLIPRISRRTPLPNIPPPSDTDPLTHFEYLPNGAVYPSSFQQPAIFEGNFQPSDELLQSMFQVPEQPKYPDQSAPMLPSLTIPRAPMMSPGMMSPADSIASSLVSPLDPFSPSPISQQGGPFTPADALSLSMLSVSNSHERCVEGIPEDVSCDMQSSNSPYMTSQWQNESIWSESDAMIPDDFDLNAIPPVEMGMSQYEGEMQFAALSSRLQGCEFQGGEFLPAQQANNDDFNDTTPGHDPFAGVFLYENTYENIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3I2</accession>
    <name>A0A401H3I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619900.1">
        <property type="nucleotide sequence ID" value="XM_027764099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3I2"/>
    <dbReference type="GeneID" id="38785904"/>
    <dbReference type="InParanoid" id="A0A401H3I2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="210" mass="22826" checksum="8A1AF19086C877A0" modified="2019-05-08" version="1">MSSHSSTSASQTIARRRVFKEDVPPRPSSGSSLSSSRVANSPSSLKRYSTEWDCPSPAKIKPNRRSSLARAPPLGSLLDVSIDEEDDENEEVEVEGRSLLPPAVSRAPQASDAKNLRWLAPTSVLKESDGPLRPSLGSVTVQRQRTRASPPSPLRQLASFTNEDRKRVPSSSTRDAYRSRRRAGGSFSAVFSKLQDREGGEHGAVEDKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3S5</accession>
    <name>A0A401H3S5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1500990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620009.1">
        <property type="nucleotide sequence ID" value="XM_027764208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3S5"/>
    <dbReference type="STRING" id="139825.A0A401H3S5"/>
    <dbReference type="GeneID" id="38786013"/>
    <dbReference type="InParanoid" id="A0A401H3S5"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="337" mass="35447" checksum="1558C2C32955162C" modified="2019-05-08" version="1">MRAIVCPRVPIAPSELVYTTTHPTPQPKAGHVLIRVKAYGLNRSELFTRQGHSPGIQFPRVLGIECVGLVKDAGGGSHWKEGDVVAAIMGGMGRLFDGGYAEYALIPHTSVSPPIKLPEGMGWAEFGAIPETFLTAWGTLSESLHLRPTDTLLVRGGTTSVGLACAGLAKSALFSTDRKPTVISTTRNKAKVDAVKASGADVVLIDTANSVEKQVMQATGGHGADKCVELVGGTTISDSGASLAPDGVVSFVGCVSGEWTIKDFDPMTVLAPRKHLTLYSSHGLDISKAPLQWIVDAVARGELSLGLDKVYKMEQTGEAHAYMEANAASGKIVCLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H418</accession>
    <name>A0A401H418_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1501340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620042.1">
        <property type="nucleotide sequence ID" value="XM_027764241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H418"/>
    <dbReference type="STRING" id="139825.A0A401H418"/>
    <dbReference type="GeneID" id="38786046"/>
    <dbReference type="InParanoid" id="A0A401H418"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="341" mass="38003" checksum="3D0BB828FE72E50C" modified="2019-05-08" version="1">MPYISASIDAFLVATAAVLIPSFYLIRRGRSSFVQPIRPDASYRTLLTLLLVAHSVYIIYFTLIFRPPNIFQRLQIPLTAPPDIVRSVLLGHSGLPANATLPKPLETLLTRISSFDMRTLYVRFGQAVVQDCEHCKTFDEYALFALPRALLEYIRETVILGLLTITGSDRERWRTYTVGALLGAAIIEGYWILTAPIHIPKNGQGVFMWHDNLWLIRQLLFLSLPVLTHNLAPTPATPPPIAGLAAARGVLEQTVNRLASLHYTHGAVMRDPALRAAAEEWWKRQRVEGEWARNDESVRHIAERLGRGFGEAHEGVQEGRLRVAARGAVVGLKAGLVPVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4H8</accession>
    <name>A0A401H4H8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1503090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620214.1">
        <property type="nucleotide sequence ID" value="XM_027764413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4H8"/>
    <dbReference type="GeneID" id="38786218"/>
    <dbReference type="InParanoid" id="A0A401H4H8"/>
    <dbReference type="OrthoDB" id="3027208at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="324" mass="36265" checksum="8929760B868AA6E8" modified="2019-05-08" version="1">MEDVCMDPPFFDDDQPNQDTEFWFADGNIVLIAGDTAFRVHQGVLARHSDIFRDLFIVPQPVEQDMLFNCPLVRLSDSPSDLRYLLRLLYDGRRYHLSRDNVKVEEAVALVRLAQKYEIDDLREEGLAKMKSIFTDDFEAWRASSFCVSRADAVAAVNLARLTGTLSMLPIALYYCSTFSPSEIIRGVPRADGTVEELSAEDVGRYIDGRVGLSTVGIVGFIGLFSQTSPDCSSSLTCEGAAKCVQKNVLNLFPSRGLRYDSCLTSLANAIDRLKSKMCQQCNEFLTKKDLERKCNVWERLPALFCLPPWSELRGGERAPSGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5Z0</accession>
    <name>A0A401H5Z0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1701820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620769.1">
        <property type="nucleotide sequence ID" value="XM_027764968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5Z0"/>
    <dbReference type="STRING" id="139825.A0A401H5Z0"/>
    <dbReference type="GeneID" id="38786773"/>
    <dbReference type="InParanoid" id="A0A401H5Z0"/>
    <dbReference type="OrthoDB" id="164951at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="437" mass="50244" checksum="514B1E79E655C68E" modified="2019-05-08" version="1">MRYEYLEQVMEWSERICQEMSMKTALKDVQSRTFTSKHLLFRAFAATGWTLWSRNFETAALKRKHYIPNAQGPWGAKPFFKLELVDRKGWQRKNQKDRNGAVEHDLEGNTYHIYDQPSLPSANVYHYLPVWIEYLEMAHYGRPLTDEDYLFPMIGANGIIQPHLPISHNVVQLWLGEFTKEAGITELYRFMFAPPSDRWTLARVRWGGWAKVTLPQWDTLIRYLLDELYMYEESHADALQPPSELADFDILGAAASSVSESNFRNSLLSIREDLTSVMSNVVSNFLSRQQANTHRSLCMRALTLCHAVVSPSMAVMTFSARGPQIEASPTSSYMQDPARFMPPLMAAPAASPQPQAPEYSMPPHDVCVLNVPIPRAGQHVKSESWCDIVELWETGIPNRGTLVLRNWPKDWLMGENKSRFAAKYHQRRVIAEEYLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H614</accession>
    <name>A0A401H614_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620798.1">
        <property type="nucleotide sequence ID" value="XM_027764997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H614"/>
    <dbReference type="GeneID" id="38786802"/>
    <dbReference type="InParanoid" id="A0A401H614"/>
    <dbReference type="OrthoDB" id="2799286at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="17059" checksum="A4457D8059BB8805" modified="2019-05-08" version="1">MVIALYQQDFLSAAGYASAFVFMGTRECSIVADTAVLVLTWVKTLQYRRAATRANARTAITTVLLKDGTVYFASLLFLNVFALGIGQLADLMAVMTTWTAALTSVLTSRFMLDLREAATAVDTSASDISQPIPLRTMTLRYGPMNNEPSEIGSLFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H625</accession>
    <name>A0A401H625_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1701640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620752.1">
        <property type="nucleotide sequence ID" value="XM_027764951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H625"/>
    <dbReference type="GeneID" id="38786756"/>
    <dbReference type="InParanoid" id="A0A401H625"/>
    <dbReference type="OrthoDB" id="5190258at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="2">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="224" mass="24437" checksum="651B40A6F54EB0FA" modified="2019-05-08" version="1">MGKSESMQSRTGGVGSTATSSSSPRVATQIFELSHLPQLSQHCIDIGFAMTKTVDEFTAKRITYETPVLVSTVVERLDKELSKETGGQAAFRVLATASSKEEIEKEINKITGGKDFALFSVLSHHPWLNGWFGRKDTPQTYLYTLGNPLVAQTMLQYDLYTGLHVPPRLLVLEKADRSGTQIIYILPSSLIAVPVGGEVNEQLKTAAEALDAKLENLVVRVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6A1</accession>
    <name>A0A401H6A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1702930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620880.1">
        <property type="nucleotide sequence ID" value="XM_027765079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6A1"/>
    <dbReference type="STRING" id="139825.A0A401H6A1"/>
    <dbReference type="GeneID" id="38786884"/>
    <dbReference type="InParanoid" id="A0A401H6A1"/>
    <dbReference type="OrthoDB" id="2803524at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="201" mass="22472" checksum="3A6D4DE37816B46A" modified="2019-05-08" version="1">MAALKDFIPKDADHVKRLSQAVEVYSHLYYKEKVKADVDAEIKAVTVIRHLTQKRYEAETLEVHADIAAEVKQMKAQHEAEKAQTEEVHAHGEFSPAEYQRMLYNMPAVFDQFLGAMAKATGWRFSVFGGGPSPEDGGNLRSMVFHSAEGSNDVKFGDTIPEFEAHFMEPFGWFLTMAFPMAVRQKRALATSLTPGSSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G694</accession>
    <name>A0A401G694_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Endocytosis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0105670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608598.1">
        <property type="nucleotide sequence ID" value="XM_027752797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G694"/>
    <dbReference type="FunCoup" id="A0A401G694">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G694"/>
    <dbReference type="GeneID" id="38774602"/>
    <dbReference type="InParanoid" id="A0A401G694"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="61"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="865"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="363"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1111" mass="125470" checksum="3EACD5AE9F439E34" modified="2019-05-08" version="1">MACTLRARRRYDQAQSPHTSHPRLYHLGVVLHDMFTGQRTRQTGFDIDGPDEVHYPTRPVDKDKAEAELVVNIKKATNPDETAPKQKHVRKCIVYTWDYHSSISFWTGLRVQPILSDEVQTFKALIMVHKVLQEGHPVTIKEAHGQTGWLETCARTVGHESPRGYGPLIKTYVQFILAKLRFHRLRPEFNGLFEYEEYVTLKGIDDPNEGYETISDLMGLQDQIDSFQRMIFAHFRHSASNECRISALVPLVKESWGIYRFITSMLRAMHRRTNDIEALEPLRQRFSSQHYALRKFYYECSNLKYLTGLINVPKLGAEPPNLMDNGNAPDLPARPKSTVVATPPPPVTPSPDAAAVSEQARMLKQYEEQQAALLAAREAEERRRRELEEQQRREFEQRQAEQAEKERLAQEQLMQQQMMQYNNQAAAQAAQQVNEFQRELLAMRGQYERDQLMLEQYDRRVKALEGELSSVTANINSQMLSKDELIKQLQDQVTLWRNKYEALAKLYSQLRTEHLDMLSKFKQMQLKANSAQEAVDRMERMERDLKAKNLELADMIRERDRARFDLDRQKASQKDEVDRLKREINYANERAEDASRSKSSEVSGVLSKYNRQLTELEDSLRAKQLQIDDLLHKLDNAHGDVERLKDEKDQEIAILQEGMDSTIQQLSEAQQNQGISEEATNTQIDTLILDNRKKLNQIIDSILQACVHKVDESIYELESPAQAGNLNSTPEYTLSMIEKAINNATEFATIFNAYLGGELGGEHVEVIKGANELAQSVSDVLVNTKGITRLVSDDVSDKLVNVAKNAGDVCLRAFLNLQSYKLDLLPQLSQRKDVAMRNNGEIRSALTKVSESVDSLVPKGGKAGALAKANGDIGDIVEQEMLGAAKAIEAATERLQELISRPRDSSRFSAVDLQVHDSILAAALAITNAIARLIKAATESQQEIVTQGRGSSTTQQFYKRNNRWTEGLISAARSVAFATNLLIESADGVLSGTHSLEQLIVASNEVAGATAQLVAASRVKANLMSKTQERLELAAKAVTEACKALVKQVKAISAKQSQEEDVDYNSMAGLDFKRREMEQQVEILKLEKDLGAARHRLGAMRRAGYHTNETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6T7</accession>
    <name>A0A401G6T7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sec39 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0107410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608772.1">
        <property type="nucleotide sequence ID" value="XM_027752971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6T7"/>
    <dbReference type="STRING" id="139825.A0A401G6T7"/>
    <dbReference type="GeneID" id="38774776"/>
    <dbReference type="InParanoid" id="A0A401G6T7"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922:SF2">
        <property type="entry name" value="NBAS SUBUNIT OF NRZ TETHERING COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15922">
        <property type="entry name" value="NEUROBLASTOMA-AMPLIFIED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="199"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="824" mass="91864" checksum="B7022CD9EC033A00" modified="2019-05-08" version="1">MASASTSTSREDPYTQWTRITDDELTTDNVEQLLKPVRDDFWAAAACVDRIVEDPTVQRSLLDLGIERTQPALERSRRAHQSPLDDDEDEGSEDARIEEQKRHESLVSHFQDEPADAQLCRIRAVLLHRLDRLNTFVQICKEAPANEEDSGPGTDDEWEDDPWAVEATTNSSEKAPPSTPGKSPLPLSIFLTASLLDISCLLASQELFAALCIVVTRHGPELWPYRFAILESVPEHALASEFRDILPAYDLSIELEQKTEFQSWRSEADFSENPTVQAALTGSGVPLDIEAPSQISSIPPRPDPLTSDELAKWYQNRIDLIISSTGMVDVALSLVQHAASQGVPQLDSLGEELSLLSRLVYDTHTSDKDTDWTIASWKSMNPAEVVCAYLANSKPETIANDISRLVMPYLFVLESRAERAGHPDPSLPNRLLYDFILGSPLEIVAAIFEASKPTLPPPQRVIRNDEDMARIALACLYGSDSLEEWPTMSRIFECLPAWDTPEDEDEAEAADTTIASLGDFVVPSTSRPRCTPTDLMLFFKPLPSSSLSHALDVLDVHLESGEILSRWSVPAPLRWFLRSNQDIAEQRSWANRMARRAGGSQDKLESQEDWEWLLEDMLKLSESGDSGSRSAFCLLSRDDIIRIFFSGLLSTAKFDIAKALLRSSTVHLLLDPHVIEDICLTCSQEFYENASSGNYHFGDMKLAYDCLGIPTPSERIVKEKEFIEATSRLCSFNLMTRSGTPITPLEIRLTKDRLSLVSRVLSSNSDAYKHTQVILELVEKLGFGGDAIAEVKTLAMLVETALQSEDFTRHRETPASKKRVRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6U8</accession>
    <name>A0A401G6U8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0107740</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608805.1">
        <property type="nucleotide sequence ID" value="XM_027753004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6U8"/>
    <dbReference type="FunCoup" id="A0A401G6U8">
        <property type="interactions" value="776"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6U8"/>
    <dbReference type="GeneID" id="38774809"/>
    <dbReference type="InParanoid" id="A0A401G6U8"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="65"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="325"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE77892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="506" mass="57489" checksum="FD3E684684A3F5CA" modified="2019-05-08" version="1">MKLDATDMRYITSDEFRVLTAVEMGSKNHEVVPTVLIVQISGLRNGGVNKLLGSLAKRNLVARVQNSRYDGYRLTYGGYDYLAMRALSKRDSMFSVGNQIGVGKESDVYIVADAEGNEMVLKLHRLGRISFRAIKEKRDYMGKRKSASWMYMSRLAAEKEWAFMKVLHEHGFPVPRPVDHARHCILMEFIDSYPLRQVSDLPSPGKLYSDLMDLVVRFARAGLIHGDFNEFNILIRRDTGEPVVIDFPQMVSTSHMNAEMYFNRDVECIRRFFQRRFRYESNLYPRFSSTRDAAGDGEDFRLDLVVSASGFKQKDQQVLEEYMGAQPHGNEGDELSDEGQEEEEEEEEEEGQEAQEEEDHADDMEEVQEGGQEPPQEFAGPPSAWTYREAEQNGLEDEKELSPPSTSRPISRSPPASRHSSRSPVRSTSPSLADRAATLSLSNVHEEPSHSKGISEKVQSELTKRRAREHRKYHSKKSAQRMGGRSKGSKAKQDGKIKVDTGGFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Y3</accession>
    <name>A0A401G7Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0111500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609180.1">
        <property type="nucleotide sequence ID" value="XM_027753379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Y3"/>
    <dbReference type="STRING" id="139825.A0A401G7Y3"/>
    <dbReference type="GeneID" id="38775184"/>
    <dbReference type="InParanoid" id="A0A401G7Y3"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="97212" checksum="82A31F8DE1F0FDBF" modified="2019-05-08" version="1">MSSASAVGSGPDYVGPHFDYWKDFSSVEGDNAQVSAHSDDEDELMDFIDVLTASYVPHPIDVSPLHPSNAKGKQIFFPDPRIQWERANTMDDSDSDDECSNSMTSDGFPAQFLDKSLYSPHGPWAWASGLSIMNPKALLDIGAGAMCSATLKTGFLGSRRVMYISRCWELKKRLRWRGFYSELALYKSQYYLKSLQGLVIPSIIGVHVDGRSVSLAMEPPHHSFWIEASPDMPDILKEIVVEGLEKIHAKGVLHGDIELRHILIGGDCRVTFIDFQESRSLRPYPDVMLGKADRPEFEMEMRMLKYKIDYKGAQGKEEAKMARAMEREGRNAQRRNAEERRYAQGPYAHIAPHLLREKYRPQIVEDEQPIEEDVLEPPPHPQDWRERWIRCRSAPRRTVVPGQTAAEVETAVAHFLDKLRRMQDLYNSNPTLSRTDVHSPGSIAVPMRKRRASETSEPEGRSKRRRLEKPSDDVADDPEPAAQVTVSWEVLSTSSINCATGDLLPASNNSSDPPKPPRVRDFATAPYEGPRGFYVPHPPTDNRLSIERAFHIRQENSTQCRKEGLPYYTKDAVMVKPASLHRYLKRGEHISMGALKRKHDDPSWMSNGDRMKKRHREKQGDRGADAEEDMVVVEANKVLDLGRRSKTSKKRSPSSRPTSVNARRGILRNTPTIKTISYAKGDWQEEADLEFSPKLGPRPLLVSKTEARPILGAVVSDLLPCARVYPDEEDSPNEGDDVARPPTSDVSLELAHTTLGLPSHFSSDGTHASGSGSARSESNEVSHQAITVPSCSPPPCTLGTTSSSVPPRIRSRATCPQSAVDRAPIDHLRRRSLSPRKTVAGCTPEEEASDSEEDERVVEAMLLGGEEDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G959</accession>
    <name>A0A401G959_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0115950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609617.1">
        <property type="nucleotide sequence ID" value="XM_027753816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G959"/>
    <dbReference type="GeneID" id="38775621"/>
    <dbReference type="InParanoid" id="A0A401G959"/>
    <dbReference type="OrthoDB" id="3270420at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="351" mass="39095" checksum="810BE361979468EB" modified="2019-05-08" version="1">MDGGPSKTEAATAPQQPYSQPNISELSSTLLGDNTRHAQNGHTVNCKSDEGQHEVTDGERQPPRLVLHTEDDVPGDQSPSTREPRMRPRMTLDLESDDMDIFYDSKLSIEDSSPKPCITPGNALHLIDDDPSPRSQTPSSVIIIPSDEPAHDHDSNADGYRSPSEPPPVRPVPRVRFRSRVRITSGVHRHRNSMSAVNGTSTPSSASDSPSSSISAPLRYQADENTGWGPLGKRLSAYASAGGWQRRGIPSAHGTPNGHSHGTQTRVGVGAGRVNERTPLVHSRRRPPYDDDDVREDEEEDSQERESRVKREQDSEFGTWPMRILNPHWWWWHLEPVVCCFYCSEDSEYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G992</accession>
    <name>A0A401G992_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0116220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609644.1">
        <property type="nucleotide sequence ID" value="XM_027753843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G992"/>
    <dbReference type="STRING" id="139825.A0A401G992"/>
    <dbReference type="GeneID" id="38775648"/>
    <dbReference type="InParanoid" id="A0A401G992"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="30"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="497" mass="54139" checksum="1BF7B00B5A8A34CC" modified="2019-05-08" version="1">MPHTFSQQFNTSVFKGNVSFSTGLFIGGKFVDGSSNGHIDVVNPSTGKVITKISEGTSKDVDLAVDAAEKAFKTTWGLNTTGRHRGVLLNRLADLLEKNIETVAAIETLDNGKTYFWAKGDVEAVINTFRYYAGWADKNYGSTIDTSEDQLVYTRHEPIGVVGQIIPWNFPLLMFSWKLGPALATGNTIVIKPSEFTPLSALYTAQLINEAGFPPGVVNIVNGYGGIVGQAIAEHMRIEKVAFTGSTLVGRKIMEAAAKTNLKNVTLELGGKSPNIIFDDADIQKAVNWAAHGIFYNHGQTCCAGSRIFVHEKIYDEFLEKFTEKSKALRVGDPFNDESHQGPQVSQVQFDRIMGYIESGVQDGAKIHHGGSRVGSEGYFIEPTIFTEVKADMKIVQEEIFGPVGVLIKFKDDDDIVAMANDTVYGLAAAVFSQDINRALTTAHKIKAGTVWVNITNHLHPAIPFGGYKQSGIGRELGEYALANYTAVKSVQVNFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9C7</accession>
    <name>A0A401G9C7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0116630</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609683.1">
        <property type="nucleotide sequence ID" value="XM_027753882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38775687"/>
    <dbReference type="InParanoid" id="A0A401G9C7"/>
    <dbReference type="OrthoDB" id="2789199at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13650">
        <property type="entry name" value="Asp_protease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="10">
        <location>
            <begin position="608"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="1120"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1428"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1448" mass="164349" checksum="68E78AAEF497033D" modified="2019-05-08" version="1">MDPQAQLAALAAGLPEDIYHALEAILRDLDHRVTHAQAPALSADDIRIALEHGFANTQFNLPPAHFTLPPAPPPPPVSVRPGQFKVDLAHFHGKDSDDLGAWLTLIEDYLRGQHIPEVDWPLQVPMLFRGEAQHWYVAQKKKIGRGFTWAELRKALTDKFDTPLRVETLRNELRSVPWKGNLTRYAAAFRDLETQIPEVDMTFGDRLSNFLSRLPVEFAKDIRRDKPKNVEEMYFLAREIERLSNLHHVPAQHQNNTNGFRKKTKGFTHRLFSSSSSSPSAASSSPSAPPTSSSPSTGPVPMDLDAMEQPPPLKTKDRVSRELNLFEGSEPPLFTDCCEEPLELSVLDLSDDAPEPHLLPTYAVQLAPSVNAKPLQLASAIIDTGAAYCYIKPSVVRRANLTTYPMTAHSVRGAGATTTSAWAHFAIKIGGWQKPICAFILDTDTLRFDMVIGQEWLQKYNAQPDWATRSWFLTDPRTCQVVRLHAMTVQQPLPLPRVAGAAASNRWASLVAAPLELYLLAEEPVTESPQETSGHKSPLAKIKSFGARLHARMKAKFPRLFRTKLGAPPAGRCEHVIDVTGTRPIRAHGRPLSPPEHEEVQKFVDEGLRDGIIEPSKSPWSAPLILIRKKDGKMRVCVDFRQLNNFTVRNAYPLPRIDDSYQNLRGARFFTTLDLRSGYWQIPLSAASRPLTAFATRFGHYQFRVMPLGLCNAPATFQNFMNDLLRSRLDRCVMVYLDDIIIYSPNLPQHLADVDWVLTRLDHQGLILHEDKCQWVQTELTYLGHIVSIAGVRPNPEKVQAITEWPRPDNVTRLRGFLNLTGYYRRFMKGFAKIAGPMYDLLKGNPRKRAEIKCYPSPWRLFVLDVDASGHAIGGILHQSQNDFPKGEGDCSRFAFKESDLRPIAFESRRMTPTEQRYVEGSPVVVRSDHESLKYFLSQKHLGRRLARFADNIAHFDVLIRYRPGRNQLAADALSRHDGQADVPDYEASGPLFANPMEPAVDHDRSALFETLKKWREDLLRDTSAEPSRRGFLVRDGALFHSVDLGQGEVFLPVPVNLDEALRVIREVHTDLGHLGVRAVAEALKSRVWLPIVTELVEFVIRRCDACQFTQREAPPAQPLHPLPRTDAFDHWAFDFIGPLVKSKEGNEYILTAMDHGTDFAYATAIPRRSHIAVIALLRRLITTHGKPSTVLTDNGEEFLSYPFQNYLQRLGIQHLHTSPYHPQMNGRLEKFNDMLVQTLARYTAPNRQDEWDQYLPDALLAQRAHVSRSHGASPFFLAFGRQPRLPHETTYDLLRAPPTDAEIATLQNCRLEHVQNLERFRTEANTRALRRLQDEARRREGTYHERALGIGDYVLRRSENPTKLHPRWDGPFIVHDVTDRNVYQLRTRNGYILRTLYNAARLKRYHPSNMDPELWYSSADLQRRDARARMQRRLDTSLGRAGTSRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9S4</accession>
    <name>A0A401G9S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0303 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0201190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609835.1">
        <property type="nucleotide sequence ID" value="XM_027754034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9S4"/>
    <dbReference type="FunCoup" id="A0A401G9S4">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9S4"/>
    <dbReference type="GeneID" id="38775839"/>
    <dbReference type="InParanoid" id="A0A401G9S4"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="170" mass="18304" checksum="D8EAB6DCCE1FF778" modified="2019-05-08" version="1">MSFSPIRSAPTDLVSVAAQEERLIFPSFTAQIAFDLGCLIRTRLQAASPKPAVVNITLANSNQLLFHAATGSGTQADNDQWVARKRAAVLRWGSSTYALHLKFNGNEALFASKSQLGPRAGEYAIHGGGMPVKVRGVEGVVGVIVVSGLTMQEDHEVIVEVVEEYLKKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA34</accession>
    <name>A0A401GA34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0202270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609943.1">
        <property type="nucleotide sequence ID" value="XM_027754142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA34"/>
    <dbReference type="FunCoup" id="A0A401GA34">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA34"/>
    <dbReference type="GeneID" id="38775947"/>
    <dbReference type="InParanoid" id="A0A401GA34"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="9">
        <location>
            <begin position="380"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE79030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="781" mass="85048" checksum="3C24105A67CBD4B7" modified="2019-05-08" version="1">MLSAVAARKARLQGPATTQPVAVIPTPTSPPAPSLTPVSEPRIVPKLQSKRKAAVQVEKPPSKKKKHAHTAESDRRTRYFEQPDVFKQQGDANLVDDDHADEDTDTSGDDMPVDGAQLNPQIIGTDQRKGATRRRAWSPSAPDSSDDEEDGVVEGNALPSLVPILAEHLRAVSHDAPSVLSTFKPAWEENIFRLSQSEVHDLSLPSYSEQTGTLLLLTAEETVTLLGTYSLTVLRGCISFAGVVLTPSRVSHRVFAPRSSPLPVIKCLALKVPLRDLSLPARLRTTATSMDAAVLLQELHTGVQGLGAVCRTFDGVFSPSRSQSNVSAFDLNLRGVHLVRHCTHDISVLVIPPSWETAMSPILQPAAQTDYSRRVYLVKGPQNSGKSVFARTLLNRLLTLYRRVAFLECDLGQSEFVPGGMVAVNVVDKPVFGPPFTHPSIPHSAHYIGAATPRNSPSHYLDSVQALIQTYNVHLQHAGLVDDTSQGVSSDEDRIVDLIPLVVNTMGWTKGLGADLSRRVEEITDPSDIFELGCRVPQRVWSYSPSEIRTYLLEPVPSTVLSHRYTPADNRTLSMLSYFYAVFPVKSDASALQNCTAMSWRTSLPLCAQPPYEVDWKSAFDRTFLTGAGTEDVVPTEIHRVLNGAIVAMVSCEPDTLDTETDDMTAAWSTSPPYKQDAAPPTPFGSSCAGLALVRSLSPVPASVLHLLTPLPPHALSRVRVLVKGELELPVWGMLDFRAGDGGEIAGVESGKVPYLRWGKGEGTGGDRRRVRRNLMRRGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB75</accession>
    <name>A0A401GB75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0206340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610349.1">
        <property type="nucleotide sequence ID" value="XM_027754548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB75"/>
    <dbReference type="STRING" id="139825.A0A401GB75"/>
    <dbReference type="GeneID" id="38776353"/>
    <dbReference type="InParanoid" id="A0A401GB75"/>
    <dbReference type="OrthoDB" id="3345311at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="151"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="28132" checksum="CF5DA8EFB6FB36D4" modified="2019-05-08" version="1">MSGNTPHAFKGSLVLSYLGLPEQYEPSPNADPIQFLLKHLLELPPHLSMLFSSVTTPKQRTVVSAIRNRRLRYTETDPVELRFASSKVTWPTLWGNERPGQHEAADERDWVEREFLGSLKPHVGKLGMLLGGYEEERALERIRTLRREQAELLDSLPEEDESEDEDNEEQPANLTPEASAEDAESLFLRSVKERFIYGLLESIDYDKVDWDERWDTARDRDAEERWFDDEEEGIEVTPSFPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB88</accession>
    <name>A0A401GB88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0206370</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610351.1">
        <property type="nucleotide sequence ID" value="XM_027754550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB88"/>
    <dbReference type="FunCoup" id="A0A401GB88">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB88"/>
    <dbReference type="GeneID" id="38776355"/>
    <dbReference type="InParanoid" id="A0A401GB88"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="148"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE79438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="598" mass="64545" checksum="039A9E7EF1E972FC" modified="2019-05-08" version="1">MSKLNANAFSFVPGQAFRVPQPAQPSPPPPQPIERPPQTEAPAPAPSITLNIGGSKPTPPAASPAPPVAAPSPVQPQSKPATPATPAPASVKSLHSHSASPAPSTASSNVSTKTLTLEKAKTDTAAIAHEVQSVADENTLRDLFGTVKEHLNIVFIGHVDAGKSTMGGNILYLSGSVDKRTMEKYEREAKEAGRDSWYLSWALDSTPQEREKGKTVEVGRAYFETGSRRYTILDAPGHKTFVPSMISGAAQADVAVLVISARKGEFETGFERGGQTREHIMLVKTAGVTKLVVVVNKMDESTVLWQKSRFDEIKEKLSPFIKSAGFNLKTDVSFIPVSAYTGANLKDRVSKSACSWYSGDSLLEYLDHMPMVDRKVNAPLMMPVSEKYKDMGTIVVGKVESGHLRKGESLVLMPNKDVVEVAAIYNEMEEEVASAMCGDNVRIRLRGVDDEDISPGFVLTSPNKPVHAVRKFEAQLAILDHRNIICAGYSGVMHIHTLAEEVTLSALLHYFDKATGRKSRKPPQFAKRGQKIVALIETTAPVCVEKFSDYPQLGRFTLRDEGKTVAIGKITKLVEGIPEEVVDGFGNLSVGANANAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC43</accession>
    <name>A0A401GC43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0209120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610624.1">
        <property type="nucleotide sequence ID" value="XM_027754823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC43"/>
    <dbReference type="FunCoup" id="A0A401GC43">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC43"/>
    <dbReference type="GeneID" id="38776628"/>
    <dbReference type="InParanoid" id="A0A401GC43"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="11">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE79711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="18615" checksum="B683EF57756CA058" modified="2019-05-08" version="1">MITYILLVSRQGKVRLSKWFTTMPQKAKAKIVKDVTQLVLARRTRMCNFLEYKDTKVVYRRYASLFFVCGIGSADNELITLEIIHRYVEVLDRYFGNVCELDLIFNFQKAYAILDELIIAGELQESSKKSVLRVVTQSDSIEEQENSEDTMARLGSLGSRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC67</accession>
    <name>A0A401GC67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0209650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610677.1">
        <property type="nucleotide sequence ID" value="XM_027754876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC67"/>
    <dbReference type="STRING" id="139825.A0A401GC67"/>
    <dbReference type="GeneID" id="38776681"/>
    <dbReference type="InParanoid" id="A0A401GC67"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="385" mass="41869" checksum="8E28FC91B9A543B8" modified="2019-05-08" version="1">MAQQLSSVNVTILGSASAQPSSTRNHSALALRLNGDVWLFDCGEATQHQIQKSSVKMGRIQKIFITHTHGDHIFGLLPLLASRLNGAGGTADGVEDPRANVNTDEHLPPLEIYGPLGTRAYVRNGLTYTHTLLGAPYVVHELRFPSDPPSSDHTSMAPYMSELSGQNFSQVDGVWPEIYMDAQVTVSAAPILHSVPCVGYVVTELPVPGKMDPKKYIPELKRTKTPMSVMSRLQQGESVQLSDGTVLHGPPRRPGRKLVILGDTYDPSPIADLALNTDLLIHEATNAHLPGIDSNTKEGDTYESVEARAKSRGHSTPQMAGAFATRIHAKKLALNHFSARYPGNDDVDGGARKVMEAIGKLAESEFQGEVVRCRDLMTFDVEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCU1</accession>
    <name>A0A401GCU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0211670</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610878.1">
        <property type="nucleotide sequence ID" value="XM_027755077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCU1"/>
    <dbReference type="FunCoup" id="A0A401GCU1">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCU1"/>
    <dbReference type="GeneID" id="38776882"/>
    <dbReference type="InParanoid" id="A0A401GCU1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="54"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE79965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="396" mass="44770" checksum="E0132E2F59F0FBC1" modified="2019-05-08" version="1">MSGINLGDEKLIFESSEAVSVISTFDDLGLKEDLLRGIYAYNFEKPSAIQQRAILPIIQGRDVIAQAQSGTGKTATFSISILQSIDVTVRETQALVLSPTRELATQIQSVVLALGDYMNVQCHACIGGTSIGEDIRKLEYGQHVVSGTPGRVFDMIRRRSLRTRNIKMLVLDEADELLNKGFKDQIYDVYRYLPPATQVVLLSATLPYDVLEMTTKFMTDPIRILVKRDELTLEGIKQFFVAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTEKMRAANFTVSSMHGEMVQKERDAIMAEFRSGTSRVLITTDVWARGIDVQQVSLVINYDLPANRENYIHRIGRSGRFGRKGVAINFVTVDDVRILRDIEQFYSTQIDEMPVNAAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD82</accession>
    <name>A0A401GD82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="12" type="ORF">SCP_0213250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD82"/>
    <dbReference type="FunCoup" id="A0A401GD82">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GD82"/>
    <dbReference type="InParanoid" id="A0A401GD82"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="704"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="748" mass="86526" checksum="F6961995DBEB917A" modified="2019-05-08" version="1">MAPNGINGAHHADNDEEIDYTDIEAKYQVHYEEGFDNVLVVDGVPVIDKSKAEKLLVKIAKEFSRKGAPIKPDDITVPWNDANGKSRGYIFVEFKNAHEANFALNAMHGHPFDTKHTFLINRFTDIERYANLDETYVEPEPEQYVAKEHLRAWLGDPQGRDQYATYRDDEVEIHWHGKPSQCEVAFNRPNWTELYVSWSPLGTYLATLHRQGVQLWGGASWQKQQRFAHPLVKLIDFSPCEKYFVTWSHDPIVVPEGAQQGPQFFSPEDEGNNIAVWDVKTGNLLRTFPTVYPDGEEKKQMQWPSLKWSPDDKFVARVTPGQQISVYELPSMGLQGKKSIKIEGVIDFEWCPHGDKDREDAEKETKAVADGVSKGTKKAKENMLAYWTPEVANQPARVVLMDFPSRSILRQKNLFNVTECKLYWQNQGDFLCVKVDRHTKTKKSIFCNLEIFRVREKDFPVEVVELKDTVTDFSWEPKGERFALISSNDPNLGNPGPGVTIKTDVSFYQLERGKGDFKLLKTLSTRTSNTVRWSPRGRHVVLATVGSSSKSELEFWDLDFNFDDVGRREGPSKEEWGSGIQLLGTADHYAVTDAEWDPSGRYLATSASAWRHTLENGYAIWDFKGQELEKHILDRFKQFLWRPRPRTLLTKDQQRQIRRNLKEYSRTFEEEDAAEESNVSAELIALRKRLVDEWNAWRAQCKEEMTEERKRRGKKIERESERHEESKEEIEVWIDEVIEQVEEEVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD97</accession>
    <name>A0A401GD97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0213570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611067.1">
        <property type="nucleotide sequence ID" value="XM_027755266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD97"/>
    <dbReference type="GeneID" id="38777071"/>
    <dbReference type="InParanoid" id="A0A401GD97"/>
    <dbReference type="OrthoDB" id="3344688at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1199" mass="135090" checksum="3012A0504B82E218" modified="2019-05-08" version="1">MSTSADNTSNSNAYWIPLLKEDNWLPWKRRVEAILNDKGLQEYVTGKTPKPQPSNDPANRAAREAEISAWGEKDLKAQNIVVLSLGDSQMVHIAGAETARAMWEQLRTVKKQRGQHGILVLCRRFYRMQAKEEDNISSHITQLRQIQEQLHLMGKVVSDEDFRLILATSLPESWDSFLSSYFGAVGGNVGAEGADNVRPQLTSQELIAIILDENRRRHERGERGQSSDQAMVAKGKKRPFGEYKKCSICGKPGHLGNECQHRDKVKCMNCGKFGHKATDCWAKGGSKAGQGPLMKRQKTERAYEAHEVESKEDEAKIAYNNDSDTVSLGSDGEIASFYEWFADSGTTSHITNCREVFATYQALEDHAITGIRLQPTQALGRGTVDVESKVGDRKVKFRLHSVLYALTAPNSLLSITRLDDAGGRVLMVYIKNRSPTQALNGATPEEKWNGMKPNISYLQEFGSPVWVLTEDATLSKLAPRANKYIFVGYMDGPKAIKYYDAHTRQIKISRNFQFSSNFPDHLPGNAPHVPQEQIGSDVPILIAQCEGEQNIFPGTLPSNVSDVPHAERRPEVPNLTTTADVRREGELGTSAPQSPAKNSRKCKQDDDPDQREESGTDAPSQLRRTRRKTVRHDYRLMHDPEADEDLDNDPDKSNAELVYIAMSTHGNADADEPKTLSDAKRSLKWPKWEQAVQTELNQLQGMETWELVEPPKDRKPVGNKWVLVKKTNKEGEIIKYKARLVVKGYSQIPGMDYTETFMPVVHLETIRAILGLAAILDWEIGQMDVKGAYLNGTLKEEVYMRQPKGYSDGTYHVCKLKKTLYGLKQSGREWNIVLNRKLLDAGFKRLFSDPCAYIWIKGDKIEIVTVWVDDLLIFTNDCALMDQLKRELRNMFEVTDLGEPRKIVGIEIERDRSKRTIKISQTKYIESILHKNGLTNANTVGMPLDPNTVLEKEEPETDDECDRDNGYALLIGSLMYVAIATRPDIAHAVQRLSSFTANPGMAHWTAAKRILHYLSGMRELGIIYGPIADVKPEDQSIFVGYSDTDYVNDIRDRKSISGYLFKLGNGTITWSSKKQTTVASSTTEAEYMASAEAAKEVVWLRTLFKEIGFEQQDPTILFEDNTAAISIARDPQFHAKSKHFDVKHHYVREKLRDKYIDIHYCPTEDMIADILTKSLPKPRHEKLTKKLGMPIGLRGSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD99</accession>
    <name>A0A401GD99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0213650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611072.1">
        <property type="nucleotide sequence ID" value="XM_027755271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD99"/>
    <dbReference type="FunCoup" id="A0A401GD99">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GD99"/>
    <dbReference type="GeneID" id="38777076"/>
    <dbReference type="InParanoid" id="A0A401GD99"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="70"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE80159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="547" mass="59405" checksum="0255B1C2415E65AB" modified="2019-05-08" version="1">MSTPQLANFKLPACYNEPMRSYGPGSSERKALQEAIAQMESELPFEVPCVVNGKPVKTGKLAKQPIPSEHAKHLCTYHEADQATVASAIDGALAAKAEWEAMPWGDRAAIFLKAADLVSGKYRYKLIAATILGQGKNAWQAEIDAAAELSDFLRFGVKYVEELYSQQPSQNSPGCWNRVEYRALEGFVLAVSPFNFTAIGGNLPGAPAMVGNTVVWKPSPAATYASWLVYQIFLEAGIPSGVIQFVPGPPAEVVGQCIAHPDFAALHFTGSTFVFKQLWKDIASHVDTYKSYPRIVGETGGKNFHLVHSSAEPKNAVMQTIRSAFEYQGQKCSALSRLYVASSVWNAGFKDLLLSEIAKLKVGSPKEFTNFVGPVIGRPAFDKITGYIRKAKEAGGEVLIGGSGDDSVGYYVQPTVILTKDPKSITMREEIFGPVLTVFVYEDSDFDKTLELIDTTTAYALTGSIFAQDRKALIHATNKLRNAAGNVYYNEKSTGAVVGQQPFGGGRASGTNDKAGSISIFYRFVSPRSIKENFLSLESYTYPSNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDB5</accession>
    <name>A0A401GDB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0213860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611089.1">
        <property type="nucleotide sequence ID" value="XM_027755288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDB5"/>
    <dbReference type="GeneID" id="38777093"/>
    <dbReference type="InParanoid" id="A0A401GDB5"/>
    <dbReference type="OrthoDB" id="2122015at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="10585" checksum="29FCC74EB18C41D5" modified="2019-05-08" version="1">MSNLSSTSSTVTATPSNITQQPIHQPPPPGQPSRIPVTPAVLRSIFASSRTTNEERSLSRVAFFRFTGFLLSCLAISVAAARGRGIKSGAALLGSLMADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDF0</accession>
    <name>A0A401GDF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0214180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611121.1">
        <property type="nucleotide sequence ID" value="XM_027755320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDF0"/>
    <dbReference type="FunCoup" id="A0A401GDF0">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDF0"/>
    <dbReference type="GeneID" id="38777125"/>
    <dbReference type="InParanoid" id="A0A401GDF0"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="130" mass="14719" checksum="306C5E818E3D7E5A" modified="2019-05-08" version="1">MVRVSVLNDCLNNIVNAERRGKRQVLIRPSSKVIVKFLSVMQRHGYIGEFEIVDDHRSGKIVIQLNGRLNKTGVISPRFNIQVSQIETWVNLLLPSRGFGYIILTTSSGILDHEEARRKNVGGKILGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDY1</accession>
    <name>A0A401GDY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301010</name>
        <name evidence="3" type="ORF">SCP_0301080</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611299.1">
        <property type="nucleotide sequence ID" value="XM_027755498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDY1"/>
    <dbReference type="STRING" id="139825.A0A401GDY1"/>
    <dbReference type="GeneID" id="38777303"/>
    <dbReference type="InParanoid" id="A0A401GDY1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="491" mass="53679" checksum="A4DC0AB3D26B12C2" modified="2019-05-08" version="1">MPLDIDPNYVLQAARLMAIVAAAPHQDDPRYLDWEMRIYLEVSRLEKSFPQPLKSLRMPGIIISALLEFTQAYQQKALAWLDHISNDDERIYKRYPLAVSEYGECEDLGRQWWTEDPYCKLPLVKSTPATGSGNVPADDNTQGRGTEDLGTGDLITKGKGKERAVNDAGTGMVGDRIVHVEVGEDKGKGKSKEKVQGKAAHAMSEEEDEREGEGEEQEGEDNDDANNDDGDENDDADKDDDDEMAEDVPSAGQPESIEVDVASPALPTARPTSISPAAAPLQKCKAVITESSEESENEEAALKVKQMKPIEVTKEKGEAPTTSAQAQHVQNRMAQTEVKGLKVSRKSGKRKVKKSSDEEEVLTTKLPKKKRATREYKSKEFIESEDETPAPPFNLPAKTAGDSNAGVAKINAPAKPVKQTMRITVSPHVTLKVKAKGKAKATGKVKAKATGKAKAMASQKDKWKKTSTHVSDFMWAHATDSLVPCVGCQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE40</accession>
    <name>A0A401GE40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611314.1">
        <property type="nucleotide sequence ID" value="XM_027755513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE40"/>
    <dbReference type="GeneID" id="38777318"/>
    <dbReference type="InParanoid" id="A0A401GE40"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="268" mass="28547" checksum="1298EBA81EB171F8" modified="2019-05-08" version="1">MSCDSIVSIINTVSFESEAHPEVLSALLQTSASLQFCSESGRKDLFGGRPQRLKSGQFRNSAAMPPRTRSAPDASEPRQTRSHTKGVQKVLTASESRSRNSAKKKKDVSPPKDEGHPATDGSKQKSSRTSKTTDVADEEAAESVVQRQGKAKLPAKRDTKAGRTSPSDSDGGDGKSVAPASEDDGIDAPSNNDKDTNLDSAEPDAHAAANLHRSVDEADAYNEDESSEEPAGDNGLHEEHGRTDVDRGGDRRVPNTEDSEDGAIYSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEC5</accession>
    <name>A0A401GEC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenylate cyclase</fullName>
            <ecNumber evidence="3">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0302320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611430.1">
        <property type="nucleotide sequence ID" value="XM_027755629.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GEC5">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEC5"/>
    <dbReference type="GeneID" id="38777434"/>
    <dbReference type="InParanoid" id="A0A401GEC5"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="15">
        <location>
            <begin position="364"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="16">
        <location>
            <begin position="1090"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="14">
        <location>
            <begin position="1430"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="292"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1689"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE80517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1791" mass="198880" checksum="56CCE0D923F91F1D" modified="2019-05-08" version="1">MTAMASPWASTSSLPHARSRPLPSAPSSSSITLALSDEVGQDAPQDLLPPQDLQPHVPPTDADNFIIAPWLAPDSGVESEPPTPPPKPQRFGFSTKPSFSSFSIPRQPSTSSITLIPNRHTDTLSTHSTETVQSTDSRRSKSSLSILTSIMKKRSRSRLRSDVRLPAEPVPPLPPSPPPSYRKGGHRPKKKSSNMILPITPISEPHFELDTNLEHMDGIIDFSVLPSAQDSGSPETASGFESSHQSSSSVSSVYNSRASPSYMFSNPFLPSTHRKLAPSTLAFDSRKISPKTSASTYEVDDTSSPSWTAPESWAVEKDGEDPLVPEYSSSEDSVPCSSPHSKRKRRKTVSSRPDGVSTATSAPKKYIIRIYRANGSYHVVSIDFDVTAAELTPQLKKKLLMDADRESHRLYLKERGRERVLAPTERPAGIVRRRLEQAGYDPADGLDLLGAEDTKYLMKFVYKSNALGPADEELNFDNFDLVDLTGRSLRTVPVLLYPHAEAIVLLNLSRNPMLEIPLDFIQSCTTLRELRLQHMAMKKVPQSVRHCRTLHRLDLSCNRIVDLDDAGLDAIPELRSLKVQNNRLDKLPSYFPALKALKDLNISNNHFRHLPSVVSELTGLVDLDISFNMISELPEGIGRLQDLERFIIVGNQVSKFPIDVFNLVSLRMLDCRRNHIAELSVVSMLPKVEQIFADHNAVHALDLSFGRSLEQLDASHNDITQLNLILGPMGQPFALTSLDISHAKLSALDEVALAQLTSLRTLRVDHNSLRSIPDTLGVLTMLTHLSCSNNQLLALPSTIGRLQKLETLEAHNNSLAELPATMWSCASLQLINVTSNFIGSWSLPHVHAYHATNVSLSPDLATSSLPGSDYNERKASTSGSRPLPPLVLSLEKLYLGENRLTDDTLHPLALLKELRVLNLSFNEIQDMPSTFFRNLTDLKELYLSGNSLSAIPTEDLHRMSKLEVLFLNGNKLQTLPKELGKIPSLMALDVGSNILKYNVFNWQFDWNWNFNQNLRYLNLSGNKRLEIRPDMNKQPMQDTQGRKILADFSSLTQLRILGLMDVTATFGTSIPDENEDRRVRTSVSEVNGMGYGIADTLGRTDHLNMLDLVKPQFREREHEAVFAMFGRATHVANNPALNKQLHDELLKVFSEELERIAQQRSETIPDALRRTFLKLNKKAHDELYKRAYEELYTNFPTRKMSNVSATSTLNPIMHEMLSVRGGASGVMLYFVDQTLYVANAGDALAVISRQGVAELLSLKHDPFNRAEIARIRQAEGWVSPKGCVNDEVEVARSFGFYNMLPVVNARPHIRTWQLNDTDEFVIVGNSGLWDVVSYQTAVDIARSERADPMIAAQKLRDFAISYGAEGTTMIMVISVADLFTKGLRSRQPTMESVIDAETFMSLKRRKRDEIKNKAISRLDNEVEPPTGHVALVFTDIRNSTHLWDVNAGMATAMVLHNNLLRRQLRFCGGYEVKTEGDAFMCSFPTALNALWWALSVQVQLLHADWPLEILECEDGKEVYDSTGRLIARGLSVRMGIHCGQPVCEPDPITHRMDYFGPMVNRSARISGSAAGGQIMCSADVVREINARIFETGMETDQSHLQSPYAIDAIRRLGSVVVPVGEVKLKGLELPEMLSLVYPDQLAGRQGLRNTQSASNSSGSRVQFSVDQMRELALLCIRLETLSSGRVFRLPPERKDSSAGPQGRPISHSDPPTVLYGDPKVLLPAMDNASDMELMLLLDSLTTRIENALNMIALNRMVKIQGLSESAQPGTLQSLLSMLPSSVLPNSIPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEJ3</accession>
    <name>A0A401GEJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0303290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611527.1">
        <property type="nucleotide sequence ID" value="XM_027755726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEJ3"/>
    <dbReference type="STRING" id="139825.A0A401GEJ3"/>
    <dbReference type="GeneID" id="38777531"/>
    <dbReference type="InParanoid" id="A0A401GEJ3"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="622" mass="66942" checksum="A92E16FB9AD7D203" modified="2019-05-08" version="1">MANVATMGPPPSPKEPRRSGRRTVPSASTSKSPAGSPASDTAPKSKDSSNRPPVSSSANSGKGKRGKQEDQDEALEGAPKNGINGNGNARAKRKGGSKDKDKTSTTDGGVDTPRAETHGGDTAAQPEEEEEEEAGVTRCICEGTGADDDADIGEFMIQCEMCKTWQHGQCMGHPDLDNVPNHYYCELCRPDMYVDLLKKYAKKARHSSTNSHNTTTAAGNTSRSSRSHSPTHLLKTTKRRNTMNSRDAAYEESVQAIIEATAAEAAAAANESISNTSAATLINGASDKHAEIEQETEVTNNTRKKRKRSDDDALPTKRTRSSSTASNPPPPSVLRDPTPVNGATAKPSPVSAPTTKTTRNRRGGGRKAQVQELMTVEGDEANSTASASNARRATTSRAKATAGQDHGGRRAQTNATNAASSASASRAYHHSHAYAVSQQPLFTSWNLPDYLAHLEPMLPTNVPRPLEVRGSGVDATGRESLERTTERGVKVRWPSKRMSVGDMNKRVRALVEWVGREQANSLERTRRRDAVGRALREAQDMQMDFREPPGDGAGTTAVTTASVVESPLQENPNIFEGETAPGQEAGLVTMKMMEELMEELISFQERFGPGAKTKERERRTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF27</accession>
    <name>A0A401GF27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0305010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611695.1">
        <property type="nucleotide sequence ID" value="XM_027755894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF27"/>
    <dbReference type="FunCoup" id="A0A401GF27">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GF27"/>
    <dbReference type="GeneID" id="38777699"/>
    <dbReference type="InParanoid" id="A0A401GF27"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="8"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE80782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="185" mass="20924" checksum="68D074EC660F6AF0" modified="2019-05-08" version="1">MNLSLYAVTAFLIIDTDGHRVLAKYYHPRSHPQGESKKLTTLKEQRAFEKGLWQKTKKAGGDIILFDSHLAVYKHSLDLIFYLIGDPTENELMLHSALVAFSDAVHLLLRNQVEKRAVLENLDLVLLCLDETIDDGIIVETDSTTIASRVSRPRADTTEIVINEQTLLSAYQTVKEKVQHRIGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF61</accession>
    <name>A0A401GF61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0305540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611747.1">
        <property type="nucleotide sequence ID" value="XM_027755946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF61"/>
    <dbReference type="STRING" id="139825.A0A401GF61"/>
    <dbReference type="GeneID" id="38777751"/>
    <dbReference type="InParanoid" id="A0A401GF61"/>
    <dbReference type="OrthoDB" id="3202382at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="668" mass="74281" checksum="E542E29C0DCCDA4A" modified="2019-05-08" version="1">MAATISTDSWDSPPQEHMSLNTLPYDLLLNVAQHLDLRDIYAVQLTCKSLHDFATTRPVFRNLAVDLLRRCRALPLSGFQRLSDLSTDQLIAAVKKATRLETAWSIRAPRPSHSSPYAEETTDSSSTPKWYRVISAPPYEEVDWLSPITSSYSLCATKSGKVVCWDVHRDICLAEWDPNGRWELWKCRVEFDIRTVFFTMAKVLHKTYDDRLMEFVLMKLHFPDSGTENGTDADGDASVAPVFSHLATFRTIGVVMNVFLLDPASRLLSAFVWVSALNTIGLYALLDWDKNEFVFIDTGIECSLSSNWSCILHKEQIVIHSEESDRAYQYFYPISLLQQHVKPSSSAKGFFPTISDRVCPAYTMSAPFVFPSPPPASATTSLSNNGQGHDNTGGPRHPAAASVTPNPFPFPPWYPESAHFVRQWWPTLSAVPRLSCTVVLLADHDPDTHRTRYVLAQHYFKVPLAEPDAHHSLGALTAAVEAGGQLHGRAGSSDSPSGVEVPHSANSGPANNTQGRPRRLEDAMMRIWYVSEPFEVVCVIDGVDEEGDDGAGTVERPRPLMAVDFGHAVWIEFVDTDRKDWGPEPKRLRFVSFPPITSDADEHETLYGKTGGASKEPADGYNTEGAVRTLEIPQELDLDAVETINIDQSQGAVIISVKEGRIFILCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG60</accession>
    <name>A0A401GG60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0308780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612065.1">
        <property type="nucleotide sequence ID" value="XM_027756264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG60"/>
    <dbReference type="STRING" id="139825.A0A401GG60"/>
    <dbReference type="GeneID" id="38778069"/>
    <dbReference type="InParanoid" id="A0A401GG60"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019438647" evidence="9">
        <location>
            <begin position="24"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="293" mass="31870" checksum="DC8550CE775B2375" modified="2019-05-08" version="1">MILRRTIRVFAYTLLQLFSLVSAQDDGSPFDCHITSGNLKYDLTALAGEHTVSRTRMSPPTEMIDSVAFNLCADLQQKDGVGAQDQCPSGTRACLTKTNRKEGEADRIFAVIPLAKSSTTDMAYTSLTSPQGLCVTFRGPSYPDPTSNDLIPQTFNLKLLCNPEDSGPSFVSYNRSDMSVEWSAPAGCLLGSSPDAPSEDLPGGDDGSGDDKKQKSVGSGVGYFFLLLFLSFAAYFTLGAYYNYSTYGATGMDLIPHRDFWREVPYMLRDVVSHLCSSVRSRQSASRGGYIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGD4</accession>
    <name>A0A401GGD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0309710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612157.1">
        <property type="nucleotide sequence ID" value="XM_027756356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGD4"/>
    <dbReference type="STRING" id="139825.A0A401GGD4"/>
    <dbReference type="GeneID" id="38778161"/>
    <dbReference type="InParanoid" id="A0A401GGD4"/>
    <dbReference type="OrthoDB" id="3364141at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="288" mass="31508" checksum="F98CA994C4E7F8D8" modified="2019-05-08" version="1">MHPWYRQPSLKRRLSHDEDEEDKPDRTPARVVPDSPSRPLSKTTHHTKRRRCDTLERGIAQLTLNTTANRAPVAPPPLVLYPTNPSASTGPTTACTQAPAPGLTITPISPPGPFGQPAWNASQTPYGYAYPYTNASQPVVLPGSVEEPTSPLAPPRAAEEEPDVPDVQMRGPSWYEIEKDRIVINDLEDSDSEENEEGSSAEGGMTLSPALLEHLANGNQSALPVFPEPDASKALVLFRPLVIPTDTSEEEKKPEEERDVPDVSPVARTDIMLDDDDAMDVEPMDIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI27</accession>
    <name>A0A401GI27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">L-tyrosine:2-oxoglutarate aminotransferase atrD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0401810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612721.1">
        <property type="nucleotide sequence ID" value="XM_027756920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI27"/>
    <dbReference type="STRING" id="139825.A0A401GI27"/>
    <dbReference type="GeneID" id="38778725"/>
    <dbReference type="InParanoid" id="A0A401GI27"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="99"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="490" mass="54669" checksum="9EAEC8871CF0BF1C" modified="2019-05-08" version="1">MASSSKVDLMHHLSAETLGRKPNPMKAIGRLIKPKMISLANGDPHFSFYPINKIQFEIASVDVKDPVASWRSASSDAPSCTLSSSRQSSSRQSSQGLSLRNSLGYTNATGIPQAQQTLIDLTKHYHSPPDHMSVMTLGNGDAISKCFRLLANRGDNFLADEFTFTSATNSGESFGINWVPVRIDSGGIMPDVLEKILSTWDPARGRRPHVLYIVPCGQNPTGSTLTLERRKEIYEIAQRFDLIIIEDDPYYFLRYTDPASDSDESFIPSFLSMDVDGRVIRLDSFSKIIAPGMRFGWVTCNPVFYEHLVSLTDSSTHHPHAFGQILVTELLSAHGWQLAGFDRWVRSLRDDYQRRRDFLLSLYARELGGTGYTTASAPAAGMFVWIRVNLERHTRFRSDVRVVGGDPAGPRTNVGPLMQELFESCLDAGLVVMPGFVFALRADPEYDDLDDPIEDRVNYVRVTFAGTEEIMEQGMSILGRVVKEFFACES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ33</accession>
    <name>A0A401GJ33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0404950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613028.1">
        <property type="nucleotide sequence ID" value="XM_027757227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ33"/>
    <dbReference type="FunCoup" id="A0A401GJ33">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJ33"/>
    <dbReference type="GeneID" id="38779032"/>
    <dbReference type="InParanoid" id="A0A401GJ33"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000020">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="150" mass="16756" checksum="6013E287CAED6DC6" modified="2019-05-08" version="1">MSLWSLLRALPHTRTAFDPSGFGSVRTATKRAGGTVANHGGSPGKRLGVKKFSDEYVIPGNIIVRQRGRVFHPGQHVGIGRDHTLFALVPGYVRFYRKPHGLRDERKYVGIALTRDERLPRDEAALGRSRYFGFVDLNTWNKEPSTPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJB1</accession>
    <name>A0A401GJB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0406400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613169.1">
        <property type="nucleotide sequence ID" value="XM_027757368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJB1"/>
    <dbReference type="FunCoup" id="A0A401GJB1">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJB1"/>
    <dbReference type="GeneID" id="38779173"/>
    <dbReference type="InParanoid" id="A0A401GJB1"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="213" mass="23980" checksum="FAB8B727080BA3FA" modified="2019-05-08" version="1">MANTIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLSFSTNFGTICFNVWDTAGQEKFGGLRDGYYIQGQCGIIMFDVTSRITYKNVPNWHRDLERVCENIPIVLCGNKVDVKERKVKTGQVTFHRKKNIQYFEISAKSNYNFEKPFLWLARKLVGNPSLEFVAAPALAPAEVQVDAALMEQYQKELAQAEAVPLPEEDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJQ1</accession>
    <name>A0A401GJQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0407820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613311.1">
        <property type="nucleotide sequence ID" value="XM_027757510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJQ1"/>
    <dbReference type="STRING" id="139825.A0A401GJQ1"/>
    <dbReference type="GeneID" id="38779315"/>
    <dbReference type="InParanoid" id="A0A401GJQ1"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053245">
        <property type="entry name" value="MitoProcess-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47563:SF1">
        <property type="entry name" value="PROTEIN FMP25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="380"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="607" mass="65176" checksum="0C806859CB8D179F" modified="2019-05-08" version="1">MLRGACQSVRSSRTCQSARRLHSQTSSSSANRALIAVSGSVATAAALWYSIHSTQGVIFNDAPVSEKLQSSRPQLPETSLNSPDSLNSIVWGSNKNHVLSMENSTADSVHTPAAVAWLDNVALRDLALHERHAACVDARGDVYQWGDGFGQKSSLSSGRPTLTLRGKNIVHLQVTPSRVFALSASGRVYTLSSSAAMQDLPAGTPTPASTPWWGTGWLWGEEEEVDFAEVVPNEKLAWGEKFVSIAAGSDHLLALTSTGRTFAHPISLKANTYGQLGFRKFDVPAPSHHPHLHVSHTRLPIELTPKSISDPYAKATPAIRRTASALSEDTGSVKAVDLTNLDDSTIRFSDKLFEVPALRGVHVDRIAAGGRTSFVKTSTGRVLGWGANEYGQIGLGSTVTLDTITVPTEVILWRSTPATMRTTCLDVYAGGDLTFFKVERSDGTAMPYIDVLACGNGQWGGLGNSLYSNAQSTPVRARNVSGLLEYSEASRNLQPIMPEDISVSPTGHVLLTLDTRSHAGPGGGGRDIMAWGANSEYQLGNGKRGTVALPTTVLTPGGERFMLGKRKSVEVRDLQNKVWKRGVDVEQYAVAGWGNSLVYWKICSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKH9</accession>
    <name>A0A401GKH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0410620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613590.1">
        <property type="nucleotide sequence ID" value="XM_027757789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKH9"/>
    <dbReference type="STRING" id="139825.A0A401GKH9"/>
    <dbReference type="GeneID" id="38779594"/>
    <dbReference type="InParanoid" id="A0A401GKH9"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF94">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="268"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="447" mass="49328" checksum="788C2D8304069EDA" modified="2019-05-08" version="1">MTTIAWAQGAARAVSESLGNDFGPTPQENVDALRDAAARLSDTPSPDAELCLKLDKLIQLAHKEMAVSSSAAQIGWRRLYTDACILRSLADIYSLNSTNAQKYALSCIARLDHAIIIAGAPGEGRLDFTIDLIAEVQSKCFRSPGAGEMLVPVPVTTPHSPTLPLTALRTYSEAVPRLDVPPSLTSFATSLSRRPFVLPGYICDWPAMNEHPWRSLDYLRAVTGPGRVVPVEIGRDYTEADWTQKMMPWDEFLDSLGRDSNQEQRPTLYLAQHNLLKQFPALRDDMMPPDYVYTSPSPTEDFPTYTPPANEDQLVLNTWLGPAGTISPAHTDPFFNFFAQVVGRKTVWLAPPSTTPSMYPYPPPSVSSNQARNPAANSTDPSMGNTSRVDVFSDTAANHGDYPLFWDNTVPQAMAVTLEPGELLFFPPGWWHAMRSEDTSFSVSMWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKQ7</accession>
    <name>A0A401GKQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0411090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613637.1">
        <property type="nucleotide sequence ID" value="XM_027757836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKQ7"/>
    <dbReference type="GeneID" id="38779641"/>
    <dbReference type="InParanoid" id="A0A401GKQ7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="467" mass="50608" checksum="0EB2AC1F92D5FA9B" modified="2019-05-08" version="1">MAPNRLIEDLSARHNLPAMASDAEPPDMLDITMGESDEEDSIAEPRRPLISDLLDSPGSAQISLPLHSASQTPLAPRHTTPSLVAPFAPSNSPHAHLHHHASPKVQASSGSVAPVEGSRALIPDPLAPAWDESRGSSPIHRHALISDFTPTAPGGMFDFDTPGISPIPRRALLEATPLPPPAHTFDFCTPDTSQLPRRSLIAEPLDATPRTSIHFDSQASTPMARGMLVDETLDAEPVPKLLDFDNSPPAMPGRRRALVIDSPGATPVRSQVRWLNSPSTSPPKRRPLLDDVLSPPPPPSVPSHSPARTFDDSNFRHDAPVIHYMKGSIEPVTVTSRMPSLAALPDELPIHRPTHWEQVPGLFPDTTQLLPMAVPGEMNAASGSQVARLGRSFAQIAAEADSSMDDDEGDSFAVSRHRAMLRERIVRLQCELNLTEDMHVANLNASSTVFQMGYILRDIHGEAYHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKW3</accession>
    <name>A0A401GKW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0411690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613697.1">
        <property type="nucleotide sequence ID" value="XM_027757896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKW3"/>
    <dbReference type="STRING" id="139825.A0A401GKW3"/>
    <dbReference type="GeneID" id="38779701"/>
    <dbReference type="InParanoid" id="A0A401GKW3"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="9">
        <location>
            <begin position="43"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="632" mass="67605" checksum="3BE5F2F4976695F9" modified="2019-05-08" version="1">MSLPPPSRNQAWCDVSALEAGHVEIPLPWILDTASAEDTSVLPALSFLFTHSVTGATLLFDLGVRRDWERLPPAIVHRIRTMPFHINVPQDVAESLRAGGADPAQIQTVCISHIHLDHYGDTTPFTGAKFIVGGASRSLFEPGYPADPNSVSASDLLPPDRTEFLEIDDAWKPIGPFPRALDFYGDGSLYLVDAPGHLPGHLNALVRTSPDGGWVYLAGDSAHDWRLIHGEAQIARTDRWGCAHVDVQQAKVHFGRIKELQENRREMKLGPLCKAQEIMDGGYAATKREIKPASASFIHVWYKNIICVNLEQSPALISVYSGPLPSTGMKVYSVAAVSLLSAPAVLSQTSVSVSYDTTYDDASDPVASLSCWNASGLHSGDLITIGQLPNFPFLGGSALAQGFDSPNCWTCWNLTYEGGTVTVLVVNYASGGFNISEEGMDTLTDGEAVAAGTVTATALQSFDDNYSDAPSQPRKTLLGGFVMLGAFFEELYVFSAIVAALSIVFTPAVLAQTVSVSYDTTYDNASELLSYVACSDGANGLETKGYTTFGSLPDFPYIGGAYTITGWNSAACGTCYELTYSTTTITVLAIDVATEGFNLSEEAMNALTNNQAVFLGRVNATAVQVDASQCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL01</accession>
    <name>A0A401GL01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0412350</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613761.1">
        <property type="nucleotide sequence ID" value="XM_027757960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL01"/>
    <dbReference type="FunCoup" id="A0A401GL01">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GL01"/>
    <dbReference type="GeneID" id="38779765"/>
    <dbReference type="InParanoid" id="A0A401GL01"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="19">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE82848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="434" mass="48134" checksum="C106F82D9661379E" modified="2019-05-08" version="1">MFSNLLPNALYYLLASFLLPQKPPPLRFELRHEHALSESSRVVFSDIKPSSFVQQAFEVTTRQMKTFRPVSQDAFYSARYRAHYSIPWDEIEVEGPNIQDRETLLMLAKMTNNAYAEEPGEREWYDLGSDWNNSYPFGWEPDADGFRGQIFVTPNNSTVVIAVKGTSAGWLVGGGGPTTRKDKLNDNLLFSCCCARVGPTWSTVCGCYEGGYKCDQGCLEESLIEDSLFYSVGTNLYNNVTYMYPNSNIWVVGHSLGGSLASLIGITFGIPAVAFEAPGEKLAAARLHLPSPPSTQHVTHVYHTADPIAMGTCNGVKSSCAIGGYAMESRCHLGKTLLYDTVSKLKWAVDVRTHGIKVVIDRLLSSDWDSDDDKQPKDGRGKRRNVPELVDEHDCVDCFNWEFGDYRNISLADAGLDVEVAASCSKRIFNIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL30</accession>
    <name>A0A401GL30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0412360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613762.1">
        <property type="nucleotide sequence ID" value="XM_027757961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL30"/>
    <dbReference type="GeneID" id="38779766"/>
    <dbReference type="InParanoid" id="A0A401GL30"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="56" mass="5857" checksum="C90759FE4536A9E6" modified="2019-05-08" version="1">MARTILLATLRTKELASSAMGFYIVQALAPGKPVAPRAGQTGRWTSSLLGQLVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLQ3</accession>
    <name>A0A401GLQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0501360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614003.1">
        <property type="nucleotide sequence ID" value="XM_027758202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLQ3"/>
    <dbReference type="STRING" id="139825.A0A401GLQ3"/>
    <dbReference type="GeneID" id="38780007"/>
    <dbReference type="InParanoid" id="A0A401GLQ3"/>
    <dbReference type="OrthoDB" id="2802122at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48174" checksum="9CD4B7E76439CDFF" modified="2019-05-08" version="1">MEPSPPALPIEIFDNVLDHLWDDPHVLAACSLASRMLLSTSRFHLFNTISLDDPAMHDLFYRLLKASPAVSSYVRHLSVDQRAVRRKGSPRRADLELILPKPPSALDRVHHLTLKNFSALELSMQSKLDIQASFPGVRTLSFMDCKFDAPLFVDVLHAFPKLSELHLHLVQVGDRRTLFNFSDPDVCVWLDNIPFTTMIPSSETLIQIDALSTSLTSPIVGNLLSKSPFKLSPRRLEITCFPSQTRCVRALLHTSGLSLEHATFSASSRNFLAKDTMPSDFLDFSCNKELVSLHMNGVLIDTWFTPQSQWAHSALSSIGASHESLREIQIDCMLLDCAQLPLLRWNRFDDQFARLAREHPGVKFTLRIRSSYAYHEQGVKFHVWARQVVDAVGDSFPILLAEKSCLLVACYQARSPAEEVVGSFPQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM76</accession>
    <name>A0A401GM76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0503790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614244.1">
        <property type="nucleotide sequence ID" value="XM_027758443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM76"/>
    <dbReference type="GeneID" id="38780248"/>
    <dbReference type="InParanoid" id="A0A401GM76"/>
    <dbReference type="OrthoDB" id="2757639at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="105" mass="11251" checksum="C0FA2B5B00190F73" modified="2019-05-08" version="1">MAVKAAPNTPSTTTADVSAKVASFRDIDNVIGVSKKCCWCCDWLSKDLPVPGQDGFVLPGTHGTTLPWSPPIFDIPLATLVPLEQALMEKLYQCSLTRVHVPGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNG6</accession>
    <name>A0A401GNG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase family Tnp2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0507650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614622.1">
        <property type="nucleotide sequence ID" value="XM_027758821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNG6"/>
    <dbReference type="STRING" id="139825.A0A401GNG6"/>
    <dbReference type="GeneID" id="38780626"/>
    <dbReference type="InParanoid" id="A0A401GNG6"/>
    <dbReference type="OrthoDB" id="3239894at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1280" mass="143225" checksum="7F2B82861DB67E03" modified="2019-05-08" version="1">MREVARLLRWGLTWLQSRPCIYVRRVVTRRNRSRITLKAMSHARPNTGRYRLVMCDCIRCGGLEVPYYLWQQHKEQDAFATTAFAARGRANVASASSHVVTGVTMASRGRGQRYGPTAALRGRGVSLRSQGVGRGSTLPSIPRKRSSSPSFHSGPLPHPTARAAQAASFPLMGDVPMEPLGSDIPDDSSPLFDMRTPSPVAFAASVDPDAVGISPALHSHTPVHMSRSPSPLLQERELGYYEDPDDEEVQRVLRMSGLDPESVPVMGNADMSTPERQESVTAAGAEIRATCVAQPPEHELDDPDSFIDTRKLPPLGTRLSDERAYLESHPKWFVRAILMVVGILHTKYHVTFRASSLILYAIRAIFIALRLLNKDDSMPATLTTLLKRLDLKDRFHVLPVCKACKSLFEPTINRKSACPKCGEKLFPPSEHAAVRELRRLLGRDPPKPPPILAAPYAPLSAEIADFLSRPGMDKEVVAWETEPSLPGRYSRIMDGDVWKTLPGPDKKPFFSKDESRLPEIRIGVSMSLDWFSCSRTSFAPSHSSGPMAFCVQNLRESVKYRPQNILVCAMTPGPTEPTAEQVQNYLKLVVDDLLNLYENGVIMKTPSHPDGICVRVALVAVVCDHPAMCKVSGFADKNHAEVPCTKCHVKQNQMFSDEGLSNGFPLRNGEDHKRLAREWKTLSSEAERAEFFKAHGVRWTELARLPYFDPVRMTVIDPMHNFLLGVVKNQWYGRWIKYNALRANTPKTKRELAIMHEFLETFESPPWVGRLPLHVGEPAGGSLSADEYKALAITVGPLILPVIWEEFCPEAKEDHQKALKKWRKAKKKWEKDTQEWERIQHAQETSAKTTRGDVTASSSTAEQVPQSEIGQEQTSGRVPEVPSPTATREGASSSTVASTKKGKKVKDPGPAPEEPRPRLQPEEMQAYMKLATALKILLSGSIFATQIDRGESLLFDYLRDFKRLYGGDGLMPNHHFAVHIAAQIRDYGPVYSFWSFLPERLNKLLKGFHLNNWGGGQLEISMLRAFKRDAQIHSMVHYVSQSKGTSDGDISAHIAQHLLHENREARGTVESIAQELAYVADDVLSLLPISLGPPSNQGVKLSDRTRASLYKLYNHDHKQVYYPTEANVPRSAHFLQQYGQVHDYALVDGRRITPVTHSSKLSAASAIVKVDLNGNILAGEVMSVFEHFQGGVTGDTVFAEMRWMKRLDRVPISDDIWSDYPELETEFWEYQKYHADADGPPAVIPLRMIRCQLARGKFHSPKMWMTTSLERHAVSFTTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNM6</accession>
    <name>A0A401GNM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0508980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614754.1">
        <property type="nucleotide sequence ID" value="XM_027758953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNM6"/>
    <dbReference type="STRING" id="139825.A0A401GNM6"/>
    <dbReference type="GeneID" id="38780758"/>
    <dbReference type="InParanoid" id="A0A401GNM6"/>
    <dbReference type="OrthoDB" id="3197626at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34880" checksum="3A866B2FC176A95C" modified="2019-05-08" version="1">MVDWSSEAELAVDADAFTKLMHCLAGVYFWEFAVSLEFDWAFLAGKKQFNWRLIFYWLGRYCLFFAMIGILTALDVTSEINCQALYTFNQLAGDAAVGLASINLSLRTMAIWSQNRYIVILLVIVILGHWALILQGRSSNTILAATFIYSMCFDALVMTLSALKLAPRAGHSQLIRLLFKDGLIYFLVAFIANLIATVFMLLDLNSVMSVVFNVPAAVASTIVASRAVRRLSKFTPNGAQVYSSTSGGFHTAANPAASHHTYNHPMGPKSLSGGVHVQMQTFAVADEGSPYGVPDVESRKIGDIESGEDAASDIKPQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNR6</accession>
    <name>A0A401GNR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614778.1">
        <property type="nucleotide sequence ID" value="XM_027758977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNR6"/>
    <dbReference type="GeneID" id="38780782"/>
    <dbReference type="InParanoid" id="A0A401GNR6"/>
    <dbReference type="OrthoDB" id="3058835at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20677" checksum="42FD28ABF9697BE9" modified="2019-05-08" version="1">MDWNRLKGWLKGKYDSPLRVESLRNELRNLMFKGNLARYSENFRMYESQIPAQEMTFGDCLSHFLSHLPADSARDLRREKPKNTKEMYYNARELDRLSNLHRGSQNHSSVSSNKKPKHLFHRGPPRSSAFSNGSAMPSISPTPVMPSALSNSGPVPMELDAMQQMPRGSNMPNTRVTLLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNU1</accession>
    <name>A0A401GNU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0509290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614785.1">
        <property type="nucleotide sequence ID" value="XM_027758984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNU1"/>
    <dbReference type="GeneID" id="38780789"/>
    <dbReference type="InParanoid" id="A0A401GNU1"/>
    <dbReference type="OrthoDB" id="2783063at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37610">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37610:SF40">
        <property type="entry name" value="OS01G0909600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33845" checksum="B7F7C94D995061C7" modified="2019-05-08" version="1">MSLYPPISQASSKAESKRLYDVPFLESNGGNFQTWKYRTTTILRLRGLYSLIDGTEVDPGTADTMKKAEWDVRNNEALAQIMLMLKDEPLNGVMYSMTAQDAWEKLNRRYEGRGKQTLAYLISDLFCSTLSDESPLEPQLNTMQQKAHILETLGLTLDDTLIAIAMAISLPPSYSTLRTILMASDSKLTVEKVINEVLSEEKRRGEMTAASALIAKHADTKSKGKDKDKNKKGKCAFCGYTGHTKDECQKFKASQVEGATAKGDKKAEKAADAKESAKIASVGEADSETLRLFVAEELARGDDLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNW0</accession>
    <name>A0A401GNW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614821.1">
        <property type="nucleotide sequence ID" value="XM_027759020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNW0"/>
    <dbReference type="STRING" id="139825.A0A401GNW0"/>
    <dbReference type="GeneID" id="38780825"/>
    <dbReference type="InParanoid" id="A0A401GNW0"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="428" mass="48697" checksum="7123526664311220" modified="2019-05-08" version="1">MRSSVHLPALQLGENQSLKKADEWRRLLTITPVLLWVCWKDEHDRIPNIEPTISPNAKTRPTHSQNCKALYFAILLLCAGVRMLASRKISMSQARIGQDFLTQYNRTLQQLGIDLTINNHLSTHFAKFIKLYGPIYGWWLFAFERFHGMFEKVNTNGHDGGCMELTLMRYWVRCHLIYEYLLALPANTYTKEREYIEAVIKSEGRSEHGGMMTELAIYRSEATTDRVKLPRVLGKHINLCIFLGPGTGGIYCLALDYCQHLYPDLHLIDDLSLGHGTAFVVTRVACMLTYICKDGIRYGSDSNKRTKADRYAFIVDKNTNEHCPVEIAALLGIKVAEKAPHICVVIHRMVSDEDIPPFPWCTYSDLLGIHVSYANRFHGYEIVPAVALDAPLALIPIHSERMGQELWASISFDHTGNEPEVMDDDDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNW7</accession>
    <name>A0A401GNW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614819.1">
        <property type="nucleotide sequence ID" value="XM_027759018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNW7"/>
    <dbReference type="GeneID" id="38780823"/>
    <dbReference type="InParanoid" id="A0A401GNW7"/>
    <dbReference type="OrthoDB" id="5370359at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="88" mass="9713" checksum="7697B6A92AA8522C" modified="2019-05-08" version="1">MGWRPSCKTGTAKWVYDGICPDPAVFGCLMALGGPPTWKMKKFTKDEFESRIGTVTASKMYNVVGITSDVTVRWSETGEFKFSGCYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPE2</accession>
    <name>A0A401GPE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metacaspase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0510790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614932.1">
        <property type="nucleotide sequence ID" value="XM_027759131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPE2"/>
    <dbReference type="GeneID" id="38780936"/>
    <dbReference type="InParanoid" id="A0A401GPE2"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="447" mass="50016" checksum="4F086169F361C858" modified="2019-05-08" version="1">MPVPVRPPARKALSVAAQYSRLKQIDEMYELEGTHNDPPRIRELLLDVYGYRDEDITILMDDESGRYAWPTRDNIMKAMHELVADAIPGDHFVFHFSGHGNQVPNTDGTEVDGLDEVIWPVDVVVHSDDSFDNYIIDDDIHDILVNHLPPETHFVMIFDCCHSGTAADLPYANDDFCPQTPISPSAQTTVKSVHVRKGSESMVHTHTVDHDLDDGLAAETPVSSPTDKLSSNRLISAYDKRPDVTSWSACTDDEVTLEAGTGGLFVQAFTNALRNKPKQSNVELLRSVTRELARITAIANKRRPPEYPDEFVIKPQLCGLHELPSASGPSGTERRPLTEVISETFPAFNHRSAVVEPFDAESKRDAEFLEKLNMMLLELMLDFHAWSTARPTHESDRTADELEREINGVMEVEKEQGTSLIEKTRQRLNEFVTRIKLALAALTGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPW0</accession>
    <name>A0A401GPW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0602310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615166.1">
        <property type="nucleotide sequence ID" value="XM_027759365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPW0"/>
    <dbReference type="STRING" id="139825.A0A401GPW0"/>
    <dbReference type="GeneID" id="38781170"/>
    <dbReference type="InParanoid" id="A0A401GPW0"/>
    <dbReference type="OrthoDB" id="2672960at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="257" mass="29585" checksum="C83D1021B2AFAAE1" modified="2019-05-08" version="1">MDPEPPAPPAIQPRLLSDPGLEVCPDFSSPLYNLMVEAFSHSQNIAQIEAIHQLVDAWKLENDARKEAWALQLQADRDIEAAAEVQHLAAQEAQQLAELELAEAERKEAEKKKPKIGNFTENETPPDFISARPSAYALEKVRKFEYVELWYFSKEGWDDAYEAQHSTADDAFSITRVENVMALKPIMSSRASRNIVKDQDLTWRQMSMAKAQYLFEIRKADWPPKHYTTILNFFFALENHEYRRCDNGEISLLHYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ72</accession>
    <name>A0A401GQ72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0509630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614817.1">
        <property type="nucleotide sequence ID" value="XM_027759016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ72"/>
    <dbReference type="STRING" id="139825.A0A401GQ72"/>
    <dbReference type="GeneID" id="38780821"/>
    <dbReference type="InParanoid" id="A0A401GQ72"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="83"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="83"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="222"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="479" mass="51648" checksum="639C15838E87CB5A" modified="2019-05-08" version="1">MPAERSMKRTKRSSPMAEGELTWAVSAEPPTFQPIMFTENLTPETFNEPPPKQTPSKSSLVPSDGDALPHPAGHKLKKPDGHVPRPCNPFILFRGWMIKQNLVPRGVEGNHSTLSSILGKTWRSLSEPGKQVWRDKARMELDRHKAKYPDYVFKPEHLKEPSASPRRKVREVGLKDEKRCEAIAALLVQGKSGDELAAAMEEFDKNHVPEVVTRFDAPVTAGAYSRGSSGPVRSARKGKGRKRAASSQATCSEPSSASSSSSSLASLSRSSSISLYESSASSSSSPWLPSDHIAPSAGPTFDPNMFGSFDEYLPSASSPCEPLTTYPNALEFFPQGSQDPGSSQAVTFHPPMLHVNTSYAWSSDSSTFSSGPGTPSSFAGVSATLHPDPAMGMVDLNGQQQIVEPFDPASFGYYPENVPGVDGSYGVPSVIDVLEATQFEPAKPAYLPTYNPPPYPPPGADLFDQAFSAYMAANSNFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQF7</accession>
    <name>A0A401GQF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0510430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614897.1">
        <property type="nucleotide sequence ID" value="XM_027759096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQF7"/>
    <dbReference type="STRING" id="139825.A0A401GQF7"/>
    <dbReference type="GeneID" id="38780901"/>
    <dbReference type="InParanoid" id="A0A401GQF7"/>
    <dbReference type="OrthoDB" id="2663544at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="205"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="309" mass="34007" checksum="C7ACB2CAEB45FDF6" modified="2019-05-08" version="1">MPTPVPETCNFPRTVSDRRNPALPLSPPMLPPVASSPLPRQTSPQAPSPLSPTMPGICAVERHVVPGPSTPPVSTSPSMVTINIVTSPNVMLSVASSSHDAPTGSLSSHCELHVPSGVHVPAAMPQPTASLAPRRTAVAHVVHGTAAPMATPSSSLVPQNSPLTPQALKWAALASKHGDERLRRHAQWDFHGEWLPYYEYQPVCQITDIWTEWAEGIGNYLPVQLLCEEWGAKWRRNVPKLKTEANRRMSVVQLVEALQKKRNWHLNIALHFLHEKYEPHYTPHQFCDFLKHDHRAGAESVLAAAAYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQI7</accession>
    <name>A0A401GQI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase patD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0604440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615378.1">
        <property type="nucleotide sequence ID" value="XM_027759577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQI7"/>
    <dbReference type="STRING" id="139825.A0A401GQI7"/>
    <dbReference type="GeneID" id="38781382"/>
    <dbReference type="InParanoid" id="A0A401GQI7"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08296">
        <property type="entry name" value="CAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="339" mass="36521" checksum="1FA30D3ADA1E77A1" modified="2019-05-08" version="1">MSHNDHPKTYKAYAFTEKGGQLKAITVDWTYPQEGEIVVKVLACGVCASDEMVKEQIFPTGFPRIPGHEIVGDVVAVHPTEKLWKVGQRVGSGWHGGHCSICSRCRTGDYMTCENEAINGIFRDGGYAEYVTLRSEAVASVPEELDPAEAAPLFCAGVTTFNSLRHMNAIPPDFVAVQGIGGLGHLAIQMARAMGYRVVALSSSGAKRHLALELGAYEYLDGSKVNQAEALQQLGGAKVIMCTAPNSSVIQELVQALAVDGELLLLALTENVSVPVGPLITKRLSIRGWPSGTAKDTEDCLEFALASGIKCHVERFPLDKAQDAYNHRASARFRAVIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQN2</accession>
    <name>A0A401GQN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0604480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615382.1">
        <property type="nucleotide sequence ID" value="XM_027759581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQN2"/>
    <dbReference type="STRING" id="139825.A0A401GQN2"/>
    <dbReference type="GeneID" id="38781386"/>
    <dbReference type="InParanoid" id="A0A401GQN2"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27133" checksum="EAD160DB094D3B8F" modified="2019-05-08" version="1">MSEITPEGRVPAEMIPPLDPSLLKLSDVETEFLHATITQDDEELQRRILGVQKEAYDMYPYPCIRAFHYVSLMMCGNSIYPMVLAAGKSGNTRFLDLGCCMGSDVRKLAYDSYPVANILGCDLRQEYIDTSHKLYQDVLTSPIHFFTSNIFDVPVFFTATSNAVPVAGHQSLPAARYGNAHLYRSVVPSVLRGDAERDRPRSGCTPEEGTRGHHLRETLRVGEGGYDRRSLGPDALRPLPVILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR30</accession>
    <name>A0A401GR30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0606510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615585.1">
        <property type="nucleotide sequence ID" value="XM_027759784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR30"/>
    <dbReference type="GeneID" id="38781589"/>
    <dbReference type="InParanoid" id="A0A401GR30"/>
    <dbReference type="OrthoDB" id="2751365at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52413" checksum="B015300F7AA4AB67" modified="2019-05-08" version="1">MDSLVPLVKVLGNSVARVRVGNTDGDEDDDRDDDRDEVFVYIRRRQVSSDQWARLCSYAHRIHAISLHDYQKTVDPSLLAHLVFLAGGQPLFPTLSMLRFRQLNAAFGREIMAFLSTSLKHVEISVGSLSTARPKVRESNAVRRFLWGLHSTATDLKHFSFSTVVKPPFIDNATSFPKVEYLDLLGCHSSTQMISSCANLEQLTELWVCLRESDNYGVPSCVGFPVLEDLVFSGLPAQIPVFLNLISSPSLGAFKYKDRILDRRVLGMPDYLDAFDLIGSKFATTLTCLVMDFPEFVDNSPVRLMNHIHPLLNIRQLEILELALIVRVELTSDDLHAMATSWTKLTHICIAAYPFVESLPSVCALASFGRHCPGLVHMQLPGVETRTPPSLDLQLPNSHGLNRLCFAGPNYGVENFDVPVSNPLPVAQFLHGLFPKLSYLSLDSLGHRWGEVELIYMSLKNGIPLRQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRE7</accession>
    <name>A0A401GRE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0700010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615734.1">
        <property type="nucleotide sequence ID" value="XM_027759933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRE7"/>
    <dbReference type="GeneID" id="38781738"/>
    <dbReference type="InParanoid" id="A0A401GRE7"/>
    <dbReference type="OrthoDB" id="2679535at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="65" mass="7436" checksum="3D81A79BFA8774AC" modified="2019-05-08" version="1">MTKDDIKVWTEQETVAMRERGDKLNIYNVNLEKAPSMGDIRLLLTTEERQSPNEKGRVLESGTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRI2</accession>
    <name>A0A401GRI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615673.1">
        <property type="nucleotide sequence ID" value="XM_027759872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRI2"/>
    <dbReference type="GeneID" id="38781677"/>
    <dbReference type="InParanoid" id="A0A401GRI2"/>
    <dbReference type="OrthoDB" id="3249754at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="91" mass="10906" checksum="8FDFDA2E6FB4D96D" modified="2019-05-08" version="1">MAHAQESPYDGDWMLYLSHVHRSASMRVRRHLWAIALELRRAYDEKLGLSEYADVQDENGKMVRSEARKEFEKLVLIRYCWDRTSEKLYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRM1</accession>
    <name>A0A401GRM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615713.1">
        <property type="nucleotide sequence ID" value="XM_027759912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRM1"/>
    <dbReference type="STRING" id="139825.A0A401GRM1"/>
    <dbReference type="GeneID" id="38781717"/>
    <dbReference type="InParanoid" id="A0A401GRM1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="1">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1161" mass="130749" checksum="F8E3E3F75A89DC70" modified="2019-05-08" version="1">MAHPLFWPGVYYFYPIGNTPAICLTRDLAPEEPANILLLGCGDPRNILYTIFCEPNAMKRKLDFTCCDVDPAILARNVLLLTIVADKHPNATAIWNIFYHMYLDDESHKVLVEQSKKLLDFSQSPQHWRASPYGPFIRMCTEFTLVELRRHWSLYACMHSLPHSRIAAICDAFSSKLAPQKSHIVLGTTRAAGPLIAKASPICAVQFERYWKTGVTFSDPERIIASKLVNPTFVYSLGGEGFSVQYGVDPLISFHYAAVLGNAKRELGVSDLVDAAQAQFKDWCTAFSSATSSLASSVPVVRCFVGEAAAVCRTLRTFGETGTVSSSIPVSQFETQLIQLDEEEYNSRGAPSTFNVIDSSNLDDHIALLNVLIITVPLLASASPSSVLYTESLNYNGENATKDFAERLHADITTFGVLLGLCPVDYLSGFTTRCNTHELLMYLKIADKPRQFHQVTTWKSPAAGDFLAVQSKQWCLPPAFEARQLGTLLYDMYHQLFEQEDANHFIERNQHNVRNAIANSNLVHYIRESFVLFLKLVRDRLRIPQGQWLDVMDQFRYIGNADQTLIMDTVHSWDFFTQLHRHGVHRFSFYDIVVPKIGRFSSWKVVPKIVRIVLVVPREKLAVLDEMKERIGTPLLRCDIRGPWSRGLRSHNVFSSVHAAFGRVISRGTESNPRVLFDKDPDGWKGTLPLVVSFTLAARYLTEFEPMETLDIYLSVRDTVASVVMLSDRLGMWLSLFNAKLMDKSHVYVLPEDFVPSEYCSTPPTVESPAPGHLAQIGSPCQMVVDLDEECEVVASLTCRICIEDKEVKRLFASERATPQVLQVSPCVMRLSVRDYTQDVVYPFPIVGSQNKLRLARTSLYIEVVVPPCGPFQKPDGMKLNPFPVVRSADVLNLWSIHRLNLPLLPILDLKSPGIEKWLDSHLGTMFSTREHSVLKKKNEDDVLALVKNSLNSIFVRSTGMQNSPVRRVFALRDAATNECDTLLFISEVRFDLHSHTLVWDGYVLPLTPELEADIRSIFSKLVKEETMSQMMTFKGELGAWKQLLPALVERCRTTWMHGVNCEYKSTGQIPRSVELHAVDPLCSCGRGKDTEGMSKVALWKDFAPYMTRVALSPLFAVSYLETVTEGVWTVQEGTILFRNVPEERLEITQSALQGLKAPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRP9</accession>
    <name>A0A401GRP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0700630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615796.1">
        <property type="nucleotide sequence ID" value="XM_027759995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRP9"/>
    <dbReference type="STRING" id="139825.A0A401GRP9"/>
    <dbReference type="GeneID" id="38781800"/>
    <dbReference type="InParanoid" id="A0A401GRP9"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000036">
        <property type="entry name" value="Serine/threonine/tyrosine-interacting protein a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="91"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE84883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="226" mass="26127" checksum="AC9104868F8AA892" modified="2019-05-08" version="1">MNEEQLREMIQGPADVEWSYEMRRQCQEILPNLLLGPLQASKSLETLQSLGITHIVCIRDAQEAFSVRPRFPDHFQYMVLDVKDSEEQNLIRLFPQAKQFIDNAVAQGGRVLVHCNGGISLSPAFVVMYVMQHFQLSWEDALHMVQNRRYCISPNGGFMAQIKEYESIYKAGIAVAAFPPQARTVSRRKREDEDDEDDEKRDIERKRLMVEDEDEDEDAEDDAMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRU0</accession>
    <name>A0A401GRU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0700500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615783.1">
        <property type="nucleotide sequence ID" value="XM_027759982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRU0"/>
    <dbReference type="FunCoup" id="A0A401GRU0">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRU0"/>
    <dbReference type="GeneID" id="38781787"/>
    <dbReference type="InParanoid" id="A0A401GRU0"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="12"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="507"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="907"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE84870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1261" mass="137646" checksum="9290CD8AD5107F47" modified="2019-05-08" version="1">MRVVATFHQPSSVVQSLKCRLTSDDSVEHLVVAKVNRLEVFSLQPEGIRRECVLEIWGRVVALRSVPVEDSGISNILVLTDHPEPKLIVLKYVADPAGASLVTTGDLSVHDRYGRQSEFVTDVLVDPTGQVAVISCYVGKLKVVQFDDGGISNQFDVSVPEFYILALTFLHTSPGTYAIGILHYDHEQRLQLLSRDLDLENLELSAAPSTILPITVLSASTFPSMDTPPLLIPVPPYTQEGTEDDFGTHLGGVLVVGGRKIIFYEHASQERRDIKRDKQRRSAKRKASAVQAEAQKATEKDKEREGRKLKPKISVKWPWSEVTAWSPIDEEGRRFLIGDAYGRLAMVAFDDTPGLILVPLGETSPAVSLTYLSSQVVYLGSHFGESQLLRIHSSPFANADTETLPIPSGITTVSSSSLMSSKGKEKAYLCRDDERAVKGGRVVSTKGTFVEVLENFQNIAPIMDAVLADLDGSGQPQIVTCSGGLSTGAIKVVRTGADFQELGIVKDVPHVTNLWPLRTQFEATSDTHIVASTLRETYVFRLDAHDAIIRLDPSADGFVGTSPTLAVRNIPRRVTTTNTGRSTSSYVDSSLVVQVTPEKVHLVNYDQALGLFSVVGTGWDPNNAHPAHRQRSIVAADLNASQFVVGLSGGRLVLLNLGESDQFQELKYRDFTDATYGITEISAISCAPFDPARKYSLHIAVSFWGTNKIAILSLESSQTYMTTICETSTLTALPRSLLLYNFGSGRGRKDADYHPHIVAGLSDGTVMSFSLKVNELKDRKVFPLGAAPVSLSTCVVDGRMAVFASGSRASVLFWERQRLHHSPVMLKDAVRGTSLNSTFFPSCVVLATSSSLLIGNVRGVDKMQIRSIPLGVENPRRIAHHPSLKVFGVACNRTNPPRIGDFEGTVSCFKILDDVSFDQLSQFVCELGEEVTAVLALPRRENQSFPCFCVGIVELEMGEREPSKGRIVMFSLGSRDGGISSANPALRLISSEHTRGCVYQLVSVEDKIVAAVNTSVVLYKIDNTDGSASLRKLTEWNHNYFVTSLVAHDTTLIVGDAISSVSILNVVGEGLQSIARDYGPLWPVAVEAIGNSGVIGANSDCNLFTFSLQRNGNRFMLERDGSYHVDDVINKFLPGGLTSGEWSGNQVLKPEQLFFASSGRIGVILELSDEISLHMTALQRNMATAIIGPGEMHHTKWRAPANLRGASDAESSFGFLDGDFIEQFLTHPNPSELLEGKMEAERITLPQPEIRDVLEKLQSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRU3</accession>
    <name>A0A401GRU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0701050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615836.1">
        <property type="nucleotide sequence ID" value="XM_027760035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRU3"/>
    <dbReference type="FunCoup" id="A0A401GRU3">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GRU3"/>
    <dbReference type="GeneID" id="38781840"/>
    <dbReference type="InParanoid" id="A0A401GRU3"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="176"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="343" mass="37640" checksum="21D81373E350AF30" modified="2019-05-08" version="1">MANRRGVSKRPAASTEEVECWSHAATSLSRLTTMYTNPEKSDTIGRVNRLLAGWPPGDTLPAEGYDSVKSNFKKLIPGLHDIKTTAEKEIVAIDDVIERLGILVALRKASEAIPPEKRVKRPRAHSPSSAPTPVLPATTITSRAVSITVPPRNSVGPQPQIPFSREPRARRDALANQLPLQEGRKVAFHPPQNTSKTSESATGGKDEEWILAVVTKCINQDRNRYVVQDPEPQEDGQPGQCYNTTLRAIIPLPDPNAPPDSAAHLNAYPSFTAGSTVMALYPDTSCFYRAEVVASPKDMQAVGRTGSSTKHMPIPMYKLRFEDDDDQEHYVSAQSVVEFPRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT23</accession>
    <name>A0A401GT23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0705690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616295.1">
        <property type="nucleotide sequence ID" value="XM_027760494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT23"/>
    <dbReference type="STRING" id="139825.A0A401GT23"/>
    <dbReference type="GeneID" id="38782299"/>
    <dbReference type="InParanoid" id="A0A401GT23"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="1">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20104" checksum="4F6B80CD7B1F78AB" modified="2019-05-08" version="1">MGVNGLWELLKPTREETSLKLLALRDRFEGRPGERLYRLGIDTSIWFHQLQEQFVARHANSSENLELRSLLHRLARLLKLPVRPLFVFDGPGRPAHKCSRKVVGMHWMVGNTQKLLDAFGYEWRMAPGEAEAELAKLNQLGIVDAILTDDSDALIFGARTVIRNYKVDAEDEVHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT28</accession>
    <name>A0A401GT28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0705880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616314.1">
        <property type="nucleotide sequence ID" value="XM_027760513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT28"/>
    <dbReference type="GeneID" id="38782318"/>
    <dbReference type="InParanoid" id="A0A401GT28"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="908"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="942" mass="103284" checksum="C4359F41553C74B8" modified="2019-05-08" version="1">MDTSIILRKYTLAEALLHIEIFTEPFDPILWKAWAVQMHVLLVLMVQAQSEAASVGIILPLPRDIPVLAQVKIHLATARTVEGGHRMIPQIADHLPAVIPHGLTARILYDDPAVREDFGLGHPPDGLPDIGTLRLWVETLCNAARELYDVMRGITGRHELADEYDLRDAVAQVQGHLAKGDRSAQNEVQQVWTHALSELVGVLEAHFKTLTDFRELDFNPREIDAICTAFVDVIIHAHAQSFPSALLLEPSQDEIDATMERLALGCDYFTEVERRTVPPPSIHIPACDACQIAEARRCRCTYAKQRAKSQATSTCTAGSPGLQTKRSRGKTATASGAYRAAESSSVEDAGPVRGHVPYVDIPPMPRPHHDVLIRESQKDLLQDLEARIMSLEEEQERLKRDNNKVTALLNKLRSAPTSAADPDDLATRVNGFDTALYYIRQKQDRMAADFATMANALRGAGVTVPTLYAEQPDSDADNEVPAGSEENDDDEEVYCPRPTLDRIANISGGILGLLGMSATCVPFQPFNLISQNSSTHTMSEFAGLQMKDYAVFIMELVAAMKVPCMWDRGWAEDMQERARAMPAHLTVEGFKVPLTLESCTEIKDALAAYKSLMAPLAASSMSKKEGKKPALTVSTSQPMHLALNHEMGSAGSIDRGSVISSAAIIGTAPVAPSAQSRHPSSLLIGSINREEHPVKRRAASLPTDPMMIDDPAPIRAASSMPPPQLQMSAPSHSQSIMADMMDNRYSCPMLRVTATLPRCPSDHFISRQMSVWSLHIAPSPIEHTGSQGSHGSPSVPAISLDDPPRHATFHSYFTDVLLANFRLLQLTEQIATLESALRRNWQCTRALKDSQHTMRSQLDAIMGALGGDPALFATRFGVLATRVDMVPAHHHEAMQGLLELEKCVRDLEGSDDEFPSEEEDEVVHSISTDAEGDEHINFDGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTG0</accession>
    <name>A0A401GTG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0706560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616382.1">
        <property type="nucleotide sequence ID" value="XM_027760581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTG0"/>
    <dbReference type="STRING" id="139825.A0A401GTG0"/>
    <dbReference type="GeneID" id="38782386"/>
    <dbReference type="InParanoid" id="A0A401GTG0"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="205" mass="23233" checksum="7A8728263A891174" modified="2019-05-08" version="1">MSTKPKVEGEKEHPPIVQCGIYGAEMLTRGPYATHAINLSIIDNCVWVWWYDRQGAIQSSGVDFVADLPYFLVLLAVFQRFTLQDGGIETRLVNEAEKHHRRIISSAGKYVAGEHPHHDREDFPFTCSAGTKVSVARSEPVYDRYSLPGRGTSMYKAKRGVPHGEELVMKIYWPEMERRSEVDILKAISKRRAKETISSGGMFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTM1</accession>
    <name>A0A401GTM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino-acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0702700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615997.1">
        <property type="nucleotide sequence ID" value="XM_027760196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTM1"/>
    <dbReference type="STRING" id="139825.A0A401GTM1"/>
    <dbReference type="GeneID" id="38782001"/>
    <dbReference type="InParanoid" id="A0A401GTM1"/>
    <dbReference type="OrthoDB" id="2794083at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE85084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23172" checksum="59233BA9405C8595" modified="2019-05-08" version="1">MEKKQDVYVQSKLASADEALPAGISGADDVRLAELGYKAEFRREFSLLETVAFAFSIMAVIGGVSSTLSFPLISGGHVGMVFGWGIPCLFIMCIAASMAELASSMPTSAGLYYFSAKLAPQKYSALASWITGWANVTGQVTLVCSIDYTVAQMITTAVAVGTDGSVKLGSGPTYGILIALLLAHAIICSAATKILARLNLFYGLVTGKLPIFSFRVMHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTM9</accession>
    <name>A0A401GTM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0800500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616446.1">
        <property type="nucleotide sequence ID" value="XM_027760645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTM9"/>
    <dbReference type="STRING" id="139825.A0A401GTM9"/>
    <dbReference type="GeneID" id="38782450"/>
    <dbReference type="InParanoid" id="A0A401GTM9"/>
    <dbReference type="OrthoDB" id="3251176at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="169" mass="18966" checksum="01B8FE00110FC9F2" modified="2019-05-08" version="1">MAPHTNKNSSAHSHESEPETEILKLPLPGQTLREGDHQLQLTEVTITGNTPTNKILKQHLAQYGLPVSGNRRVLRTRLRDFANDPEQWAGLFQASRKRKRGDYTGSRANKHSSKRIVTLFGEREPVVEYPCKRSGDLCVPQPLQHSVVAHNDTWSDAVLGDTATGRRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUU9</accession>
    <name>A0A401GUU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0804870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616876.1">
        <property type="nucleotide sequence ID" value="XM_027761075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUU9"/>
    <dbReference type="GeneID" id="38782880"/>
    <dbReference type="InParanoid" id="A0A401GUU9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="73" mass="7851" checksum="6BB14206D7016E29" modified="2019-05-08" version="1">MAVYDLRLRGGSHTDAEAATLAASLAHRASVGSRLGNLTLDTGEFPEEESVEGLRAVVDVLDYTNYSAEIQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUV4</accession>
    <name>A0A401GUV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0800310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616427.1">
        <property type="nucleotide sequence ID" value="XM_027760626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUV4"/>
    <dbReference type="GeneID" id="38782431"/>
    <dbReference type="InParanoid" id="A0A401GUV4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="78" mass="8445" checksum="58BF0C41826A6BE8" modified="2019-05-08" version="1">MEGRHAHDAGRQSCSALDQMENGEGTAGADNGEKGFDAERRCITSTTNRDTVNLGSEQGLLAWDGTYLHHDWLVLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV18</accession>
    <name>A0A401GV18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616946.1">
        <property type="nucleotide sequence ID" value="XM_027761145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV18"/>
    <dbReference type="GeneID" id="38782950"/>
    <dbReference type="InParanoid" id="A0A401GV18"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10657" checksum="6FAAF3C22B501968" modified="2019-05-08" version="1">MDEITRKRPLLLRFAPRPRSSQLTPPVRLLGPSAAAVREVYIDRVWLLIAPLASIAVYAEPYALDRAPFVNNSRSLSPTFRSSVLRSQRTIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV23</accession>
    <name>A0A401GV23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amine oxidase</fullName>
            <ecNumber evidence="14">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0805700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13 14">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="14"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616959.1">
        <property type="nucleotide sequence ID" value="XM_027761158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV23"/>
    <dbReference type="FunCoup" id="A0A401GV23">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GV23"/>
    <dbReference type="GeneID" id="38782963"/>
    <dbReference type="InParanoid" id="A0A401GV23"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="134"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="302"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="12">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="13">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE86046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="748" mass="82945" checksum="A5339F120B6A69B3" modified="2019-05-08" version="1">MASTNLAPSTATTVQDTISAKPSTFQHPLDPLTPDEIIAVSLSVRRYAAAKTQVKALRFITNTLVPPPKKVVLAYLGIPLNPGEKPQPLSEIVRKAEVDFIDAVTGDAYNSLIVLKDAEWEVESIEKLPEGVQPQISVEELLLCENIIREDARVQKLAADVGIKPEQLFADGWAIGYDDRFPKNQRIQQALLFARSSQHDNLYAHPIDFIPVIDSISKKVIHIDFPPRYLPKASPNSIFKKHGMDVELSCAGTAPPPLTEDAEAAAGRERIPPPSAPCNFLPDLIAEEPGKEFKVRDDVKPLHVVQPEGVSFKMDGHVLEWQKWKMHIAFHHREGIALSTITYNDDGEVRPVFYRLSLAEMVVPYGAPDHPHPRKHAFDTGEYGMGTMANELALGCDCLGQIHYLPGTYVAHDGTAVIVKNVICIHEEDAGLLWKHTDFRVGGRSHAVRSRRLVVSMICTLANYEYIFNYLFYQDGNIELEVRLTGILQVYVTPDDEPTAFGVKLAKGINAHFHQHLFSVRVDPMVDGLHNTVVETDIVPLPDAPTGSVANHAGNAFITQSSPVKVQSEGGREIGFATDRRWAITNPKRVHPASGKNVAYTVTGLRGATAPMMAREDSWVAKRSIFPKRPLWVVKDKEDARGSTRMWPSGKYMPQTRDEPENSLAKWVQGEESLVEEDLVLFLTVGITHIPRPEDWPVMPVEHIRLLFRPTNFFTVNPGLDVPGANDKRSVAAFSSEGNGQNGHACHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVC3</accession>
    <name>A0A401GVC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0900540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617090.1">
        <property type="nucleotide sequence ID" value="XM_027761289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVC3"/>
    <dbReference type="STRING" id="139825.A0A401GVC3"/>
    <dbReference type="GeneID" id="38783094"/>
    <dbReference type="InParanoid" id="A0A401GVC3"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="93"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="204" mass="22786" checksum="00797BB19BC09F7C" modified="2019-05-08" version="1">MASPPTPSKQLEQSSSSQEGLVRPFENAKGLLVVLPDTIDVEEEARLYDELCDTPINSSTIPPSPPHSPREAQSVFSRDIWLGDNSGESLTFTRSVEIGGWTSVGDKLGGAYVVYDCAIRTKEGIVIHVHKRYSAFAELYAKLRATLPESQQHFVPLLPPKSPLAKFRSTFLDHRRRQLQYWLSAVLLHPEIGGCQAVREWVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVI9</accession>
    <name>A0A401GVI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0900780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617112.1">
        <property type="nucleotide sequence ID" value="XM_027761311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVI9"/>
    <dbReference type="GeneID" id="38783116"/>
    <dbReference type="InParanoid" id="A0A401GVI9"/>
    <dbReference type="OrthoDB" id="3253976at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="255" mass="28508" checksum="0EE1ABB18AF7E32D" modified="2019-05-08" version="1">MANITRSAKSGIDWTQNELQAYHIQVVEQDATAFLGVPALPLSSVPQEVLTTASADDMADDRNFTLARYMELAMNPKPGQESAVIDFARHLLEMLGYAPRPRVIRTRYDILLFICGAWKHTQTDVCIMDEDEILLLVQENKRHLEQVDAEPQVIAGAVAAFRTMNMIRKPQPPLQSKVMAGIILTGTFPTFYKIPVTVELVDAVALGTYPAAQTVVFTHTPRVPRLNRRYSEGMKPLDSRAVILSCYEAFKAFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVN5</accession>
    <name>A0A401GVN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617152.1">
        <property type="nucleotide sequence ID" value="XM_027761351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVN5"/>
    <dbReference type="GeneID" id="38783156"/>
    <dbReference type="InParanoid" id="A0A401GVN5"/>
    <dbReference type="OrthoDB" id="7862095at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="74" mass="8278" checksum="9E8BA3F8B928BF1E" modified="2019-05-08" version="1">MTVEQLDDSTRKGEYNLTTIDIRKALLNPVGGPYSDVRHAWSRMSSSRGALTSSLGKRMRLQVSLALYYGECLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVS8</accession>
    <name>A0A401GVS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aip3p/Bud6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0901790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617213.1">
        <property type="nucleotide sequence ID" value="XM_027761412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVS8"/>
    <dbReference type="GeneID" id="38783217"/>
    <dbReference type="InParanoid" id="A0A401GVS8"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aip3p/Bud6 N-terminal" evidence="2">
        <location>
            <begin position="78"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="191" mass="21638" checksum="83818BBD87D65BD5" modified="2019-05-08" version="1">MVRTLLPYRSQPQDLPAYSPIHTKVRDPRCPQPAALTTVPASSRYSYHETTPSPTTPTPPRSPVPFARPQTPSDVLDAVSRLLALTKQLQEVLHLWGLRQAREAHVSDAFVLLGAQFNTTVILFWQHNVDISDLFHLIVQLRTLLERCLGEEPSPAALARYTPAVRRVVYDLLQGLRSKQQPFWAACRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVZ8</accession>
    <name>A0A401GVZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0902420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617276.1">
        <property type="nucleotide sequence ID" value="XM_027761475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVZ8"/>
    <dbReference type="STRING" id="139825.A0A401GVZ8"/>
    <dbReference type="GeneID" id="38783280"/>
    <dbReference type="InParanoid" id="A0A401GVZ8"/>
    <dbReference type="OrthoDB" id="79830at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="931"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="739"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="611"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="745"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="958" mass="99415" checksum="5687CBA474B74727" modified="2019-05-08" version="1">MSTSARRLDLTASRRQTRTNNSSPYSRNKGAPKPDHTTVTAPAPTEERVPLSKKWSLTGLLGFLNPFASRPEPKATVASDSDAARNLAERGNQLANGVMARTHADEQEAMETHIDPAPTPAPEPDPEIAPAPAATPAPAPAPSANSETISPADAPMDTDASSVPPTLPPADEPRTTAENLATVQAFLTEKGGKPLNAVELAGIVSLLNNSVEGAQPASGPKPEPFRFSESPSSPGRGDTPILDFTSPGTAPSGQKVLTKNPNGMYRLQGGGTARPRNRYHSPAFGPSRSAPTMTITPEKFKTDTKRRRVGQDAATSSPQRVPVSTSMPLNGAAGPSAPFANGASISTSTSASAYPFVQPNGTARTRPAPRLNTPVKPTTPARPSPLRQTWNGSPPSPPQPRPTSKPTRAASFMTELIKEVTPPKKPDLVNPYQAASFTPMRPLPQKQPTRKAKAAATAPPSAASTSNAKPPLEKKESQLSQQAIIEATVPKGYKRSRPPPNLKSAKSQASTVTSASTFTAPSEMRRPEVLETQSSRGANGASLANAKRPYQTVVEEVEDEDAPPSPPKKQRTNGASTNGRAAPPPVTIEEVDDVDIPTAQRPGPPPIFMHPSEVVEPSSRSASSSTASPMYASGAGSSSVGVGLLPTAARSMFGNIKSSAPKAPSKLRYVIQAEREQEVEEVEKITQDKEEPGNAGVDRVPPPALTAPSSSFGVSGFSSYATPGSSSFGKSGLPLSAKPGNSALAAAGSSPFGTTSSSSFAAPSSSSFAGPGTSSFSPPVASSSTAPGPFSFGAPKLSSFKVPESSPFGTRSSSSSTAPAFSPFLTREASSFGAPAFPSTSAISSFKPVKPSMAVDARSTAMEVHEFPPYTFPGRQVGPSLSKPLARRRAMSVDVPSAPAFEFTSRTSPKVEPIVGFNWTAAGLKPPPKPAAGSWACSLCMVNNTGGATKCIACDTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXC5</accession>
    <name>A0A401GXC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1001130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617784.1">
        <property type="nucleotide sequence ID" value="XM_027761983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXC5"/>
    <dbReference type="STRING" id="139825.A0A401GXC5"/>
    <dbReference type="GeneID" id="38783788"/>
    <dbReference type="InParanoid" id="A0A401GXC5"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60464" checksum="F95832DF73EE3AF8" modified="2019-05-08" version="1">MEVAEKQTVWKSNDEATEQIVDISASASVNAGPDIDLFSYHERNAGRLVVDPEEARVEFGEEVAKRLKLSSDGTRVLWPQPTDDPEDPQNWSDVRKNFQLFIVTLAAIVPDFDSGIGIASIFSLAKQYNTTSGVINDLTSNWSIFLLGWGSILAVMLMRRYGRLPILFWSQVLALGFLIGCTFAPTLKVFTAMRCLTAFFGTCPQVTGLYVVTDLFPFHLQARKLNIWTMGFVVAPFLSPFAFGFLVARANWRWTYGTGSLYGVVVVLFITFFMEETMYDRTLPNPRPIPPPPSRLHHRVELLVGVTGYRMAKYRTKWRIAVWATADVLWRPHILSILVFEAILFGFTTGINTTNAVLLDLPKPEGFGFSQYAIAGAYATPIVATIIGELLGHYINDWLMNFCVKRNKGVFEAEMRLWICYLAVPLYICGFVVLGAAFQLHRGVGALVMGWGISQVAVMLNTVAVYAYCNDCFPSRQGEVSACVNLARTLGGFSVAYFQVPWVTQHGALQAFGVEAAVVTALFLLVVPALQIKGASLRAKFSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXP8</accession>
    <name>A0A401GXP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1002180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617886.1">
        <property type="nucleotide sequence ID" value="XM_027762085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXP8"/>
    <dbReference type="GeneID" id="38783890"/>
    <dbReference type="InParanoid" id="A0A401GXP8"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20392" checksum="BDDD799D706342BA" modified="2019-05-08" version="1">MSETNLPPPPFSPIITLGASSIIDAPIEKVWDVLVDFPSYGEWNDMVHAQTIVDEHKKPLDSQILQEGRHLLMEVHIPPTSDRSHKPTSHAFELITNVDHAAHRVCWVSTYPRWFIEAVRWQTLSPVDGEEGKTKYESREVFRGIGSWILRWFLAGGLQQGFDACAQGLKRRAEQVHQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYD0</accession>
    <name>A0A401GYD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1004490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PAAF1/RPN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618115.1">
        <property type="nucleotide sequence ID" value="XM_027762314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYD0"/>
    <dbReference type="STRING" id="139825.A0A401GYD0"/>
    <dbReference type="GeneID" id="38784119"/>
    <dbReference type="InParanoid" id="A0A401GYD0"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF19">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT RPN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="658" mass="68757" checksum="9F427FA0BFFDE13B" modified="2019-05-08" version="1">MLKPLLDAPDKRDGLLDLRKQAHVQETLAHHRLQQVPQPRATLVDGRRGLERDSLGRLQDAMALRAGKCAKRDERVLGEGVGAAEDGGGSGRVVVLAGDTVELDDLDDELGVAGAVMPEEGDVTRLALEALGFEADGLGASLSESKELRIIDQGRSGHAEHASFPPPAMSSPVRLAICTIQADFPDVINDVRTAAVPDGAFWLSCYKTGEPSVHAKVHAALDDHDRDLVRLSPSHDVRLSVTGGRADAWQAEYSAACPALDLPDTPLIIPVQSYSDPSPSDPRRAHKITAFDVAPDRSQLATAYSDGTIYLRRTSPLSSSAPSPRPYAQAKPHLSTPTVLRFFPSSRVLLTAGLDFALTILPADPPTPGTPAQPAPTRLSPVRTLKGHTRAVTATAIVGRGRTVLSASRDGTLRLWDVPSATQIRALPSAGGACVPILALTVGARQGEGDGEGNADVDPREVETSDKLAFLALADGSFEAHDLRTKRAVLRVPSTAPLPACALQAIAYDAPRAALATGDAHGIVRIYDVRAGDARPLAAVQRNTAGIEDLAWLPFPSPPPSPSPSSRSRSPSPASFPHPHPNGITSAAAALTLAVAPADGLAYLLTLGHGGAAPGVCAELVGADCEAVSCVRAFAVEEGGGAEVWSAAADGVVRRYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYE9</accession>
    <name>A0A401GYE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SCP_1004800</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 27">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618146.1">
        <property type="nucleotide sequence ID" value="XM_027762345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38784150"/>
    <dbReference type="InParanoid" id="A0A401GYE9"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="424"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="688"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GBE87233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1337" mass="150929" checksum="1313074736DE9030" modified="2019-05-08" version="1">MSTSADNTSNSNAYRIPLLKEDNWLPWKRRVEAILNDKGLQEYVTGKTPKPQPSNDLANRAAREAEISAWGEKDLKAQNVIVLSLGDSQMVHIAGAETARAMWEQLRTVKEQRGQHGILALCRCFYRMQAKEEDNISSHITQLRQIQEQLHLMGKVVSDEDFQLILATSLPESWDSFLSSYFGAVGGNVGAEGADNGPLMKRQKTERAYEAREVESKDDEAKIAYDNDSDTVSLGSDGEIASFYEWFADSGTTSHITNHREVFATYQALEDHAITGIGPQPTQALGRGTVDVESEVGDRKVKFRLHGVLYAPTAPNSLLSITHLDDVGGRVLMGKKNGRLYSLKLHPIVPQPARTYTAKEYGPHTWEEWHKIYGHIGKPALTRLYREGLVDGLEISPSPDEINCEACIQAKATQKPFPKETDECSKVPGELTHTDVWGPAQTAALQGWKYFITFTDDYSRRSTVLFMRHKDEVTEKVKNYITYIERKFGNKPLRLRLDNGREYMNTELINWCQMKGIEMGPTVPYSPSQNGVSERLNHTLLGLARAMIYARDLPRYLWAEAIAHAVYIKNRSPTQALNGATPEEKWNGTKPNISYLQEFGSPVWVLTEDATLSKLAPRANKYIFVGYMDGPKAIKYYDAHTRQIKISRNFQFSSNFPDHLPGNAPHVPQEQIGSDVPILTAQREGEQNIFPGTLPSNASDVPHAERRPEVPNLTTTADVRREGELGTSAPQSPAKNPRKHRQDHDPDQREESGTDAPSQPRRTRRKTVWHDYHLMHDPEADEDLDNDPDKSNAELVYIAMSAHGNADADEPKTLSDAKRSLEWPKWEQAVQMELNQLQGMETWELVEPPEDRKPVGNKWVLVKKTNKEGEIIKYKARLVAKGYSQIPGMDYTETFAPVVRLETIRAILGLAAILDWEIGQMDVKGAYLNGTLKEEVYMRQPEGYSDGTYRVCKLKKTLYGLKQSGREWNIMLNRKLLDAGFKRLFSDPCAYIRIKGDKIEIVTVWVDDLLIFTNDCALMDQLKRELRNMFEVTDLGEPRKIVGIEIERDRSKRTIKISQTKYIESILHKNGLTNANTVGMPLDPNTVLEKEEPETDDECDRDNGYASLVGSLMYAAIATRPDIAHAVQRLSSFTANPGMAHWTAAKRVLRYLSGTRELGIIYGPIADVKPEDQSIFVGYSDADYANDIRDRKSISGYLFKLGNGMITWSSKKQTTVASSTTEAEYMASAEAAKEAVWLQTLFREIGFEQQDPTILLEDNTAAISIARDPQFHAKSKHFDVKHHYVREKLRDKYIDIHYCPTEDMIADILTKSLPKPRHEKLTKKLGMPIGLRGSVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYP3</accession>
    <name>A0A401GYP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1005350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618200.1">
        <property type="nucleotide sequence ID" value="XM_027762399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYP3"/>
    <dbReference type="GeneID" id="38784204"/>
    <dbReference type="InParanoid" id="A0A401GYP3"/>
    <dbReference type="OrthoDB" id="2752889at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="374" mass="40730" checksum="085111B2441C9FDF" modified="2019-05-08" version="1">MSFLSVPTISNLPTLSESGTGDSADPSPLPSGLCTPGETYLHSGDDILIASKIPFTDDRFIVAQDKSLQVQLEQLRDSKIKAKPLSRVVSQAKKLAGRALSVRKAFRKSSETLNASLSSSSLGPDFPGGWKAERVTQSEARLSISSSQEIVSRIGAGREDGDESIVQTHSSSDYHPETLGNYSHVDPDELFNFFEELLSSDTAHDSYWKLPSLHTATSTILRITLFLPWCAAVGGTVLLSPQHLELVAFTPGYIASPKGLQRFAHWTDCATHHVFIFLACIIALALWDVALGTAVAGVALARFIYVWSDFRVDASVPLGEDDKQSVYLAVTQAYINDGDLVFRTSKTDNHEGNRLLDGDAMDEEGEEEERPLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYR4</accession>
    <name>A0A401GYR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1005480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618213.1">
        <property type="nucleotide sequence ID" value="XM_027762412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYR4"/>
    <dbReference type="GeneID" id="38784217"/>
    <dbReference type="InParanoid" id="A0A401GYR4"/>
    <dbReference type="OrthoDB" id="2662268at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="242" mass="26614" checksum="D288009F11B524C4" modified="2019-05-08" version="1">MRFLFCCAPHGHFTTPPLARSCVFLPSAAGMYCEENTHARLSSTTSRCPRKRAAHLLPGAPVGDVLYKTTEEQISSYTSIGRVTLQEVPWRPPSSHIVPRQIPITERIGSIPFISAMGRGISLKDALGLRVGATNTLQRPDDLVLANVGLTEIQLIVLWPAYEGQRLVSVNVPVSRWTLAACIANHYKQFFEDITKKELAGPFSTWNVGAQRDGKIPISKVVLLGLKQVYADIFCAEMGVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0C0</accession>
    <name>A0A401H0C0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1201020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618790.1">
        <property type="nucleotide sequence ID" value="XM_027762989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0C0"/>
    <dbReference type="STRING" id="139825.A0A401H0C0"/>
    <dbReference type="GeneID" id="38784794"/>
    <dbReference type="InParanoid" id="A0A401H0C0"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000008">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="473" mass="52622" checksum="1CBF1EB63DCCB767" modified="2019-05-08" version="1">MHRLAYNASGIRSLHSLSAHKTSISAGTRSVRWRRKRYVSATPCRPLVKAVDHTVTNVEKILLDTIRATGPISYATYMQMCLSHPVYGYYMNQDHAVIGSRGDFTTSPEISQVFGELVGIWLLSQWLHTGASRKIRLIELGPGRGTLMKDILLTFNKLSTAKSAVKEIHLVETSPAMIRQQNASLAPFNLDIHWHSSLDAVPPDPTRFSMVVAHEFFDALPFHLIEKRHEGWHEVLIDRSPDSVDSQVEERQQKTQLTTSLDLGSSPPVSLKPRFRQVLSPTPTASSSLLGQSSPRFQRLPVGTRLEISPAAFKTARRIAELLNPEDEGESGGCALIVDYGGDKAYGNSFRAFKDHKIVDVFHRPGECDLTANVDFQYLKDATADLVLSHGPLSQATFLKHMGIDVRVEALQKAAQSETRAKEIKEAAQRLVDLTGMGSQYKVMGLSGKTVQKVPPEARWPFLEVDYKTSQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0F1</accession>
    <name>A0A401H0F1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1201160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618804.1">
        <property type="nucleotide sequence ID" value="XM_027763003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0F1"/>
    <dbReference type="GeneID" id="38784808"/>
    <dbReference type="InParanoid" id="A0A401H0F1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="17627" checksum="0FE77FB7D70386C0" modified="2019-05-08" version="1">MVAGAVVASSIVIWSLTSSWFLLEKEFKKTREALARSIRAIDGIKPEDRQIIRKRSPNEFDELERLHSNLKEQLEKLQKLEQLMVSVGPLSLYRVRFLVSTQLDTIVMLTKCADILLLSLIKECRADEQPVAKSDATNRSANSESESPGLAEDKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0T1</accession>
    <name>A0A401H0T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1202380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618925.1">
        <property type="nucleotide sequence ID" value="XM_027763124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0T1"/>
    <dbReference type="FunCoup" id="A0A401H0T1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0T1"/>
    <dbReference type="GeneID" id="38784929"/>
    <dbReference type="InParanoid" id="A0A401H0T1"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="481"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="967" mass="108470" checksum="7521FC4012EB6300" modified="2019-05-08" version="1">MHRHGAHSLAERAAWRATSNQHVHLSDVGVARRYSYSIPKRSAPAALPHDDFEVVEHWTKRLIGKSNLDGKKGWKTTQGYGGEAKQLAASLSSKKHPLVGSSMEKELFLSAPSFSDSTYLEEFESQPSKTFEPGTLIEIRRNDIVSHAIVLYGSFLDTAFIYYSLSVTGELWPHTDMDIMFAISSFMDQDLVERCGREIDAQDEHQLAARVHALKRLRGFEVALERKTNVLSHSLVPLYEKCCAEDPNAWSQVTENEVARMVDPYSNPIPLMTKFVVHKHLFKQHKHFVAESRNFSSKQSFWVRPRHHLADLNLVDTMVLRRDPRLLAFIGKAKRKILASRAVTLVSWTEPPSEQLDTSMEFTPDDRLFIRYFQHANRSRRTIQEDPYQLAQSDILKRIDLYTGDIDDAMCSKFLSEIGVLPPWEDVITRGDYHDTLETPPLRMPKDKPGGKTPSLVMRPQSAQPLGPEDVYPHDIAESIRHDFGDLPVYVIDDAIAEELDDGISIESVPSQPEHAWIHVHVADPTSVIPPTHIWARHALRKVGTAYWVDRTIPMLPRHPLIDQCSLGSRQKNGMSQPTLTFSLKVNEAGRIIDYAVRAGLVKNVTTLTYADVDAAMGHSGSSSHYPFGNRPTSIRLRDTSPIDIAILKDLTALKNVAGRILADRIKHGAIAYSRNKVEMFLPSKPLPSRTAGFSSPSVFRGFPEVIYSVTETLAQDSGSRGMVSEFMKAASRVASCFFRDRGLLGLRRAVGTFQTEVEGGVEQLLASRDSAGYVNGADVLRFRTVTPSSWYQLTPGPHGILGIPASDGYLRVTSPLRRFSDMVAHWQIKHTLVNSGSSAGSPFTEQWLLEFIKWLTYGEDRMKRAAVLQQNFWAVSFIQRWMAGDDARNLDRPDPLRSLVGRIIGTMIHNRHLASDQINLDIPALGLRAILVGLDKSDNCPLGDEVAVKIDTARCGLRPYITVTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Y8</accession>
    <name>A0A401H0Y8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1203260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619010.1">
        <property type="nucleotide sequence ID" value="XM_027763209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Y8"/>
    <dbReference type="STRING" id="139825.A0A401H0Y8"/>
    <dbReference type="GeneID" id="38785014"/>
    <dbReference type="InParanoid" id="A0A401H0Y8"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14516">
        <property type="entry name" value="DSP_fungal_PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047949">
        <property type="entry name" value="PPS1_DSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="886"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="978"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="641"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="769"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE88097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1103" mass="119306" checksum="59A657EFA30BE414" modified="2019-05-08" version="1">MTNVDDVHGLAYPDGFLDTLPVLHHRPPPPQPTRVPYPFLEGYNSPPILRYQHQPIRVLDADRFADVHLRYLTTHAPDHVLFPFLHGLEGDNAQQNAFFTSPHNSTPIPRFRGLVWVAADADDADDVDAEDIDELDDDDYSESSFDSESVGPMDIDDDSSVARDPTLAGPVVTGCPPPHALPPAKAKAVAPVAAPPLLRVHVVPASGPTPTPTPKPPPAMLTSSFRPRELLRADVDLYGKSSYAFVEPKVPAGISLRNFGIQAPIYAALSDIIVYSPYGNTRHAATVAERFASAVEAKRAARTAQIGADPGVGYNVFVLEAGPAELARAVPHAIMRLEQGPTDAHTDGTDAHAHGDSRQGKPAQLRANTVDFTRREKEEMRDLTQASEIVSVAPEEEEEGVALETWDPETVCGSTPASVWEPALGQVFLGNSNDVPLPPDRRLRVRSAAMEDDEDDWDWRGDNDPANGKGFDICIECHDFAPFPSTAHVRAAEEHVAALERRWIARCLAQEERGGQDVKMDLDGGDEESKSIPPRPPPSAAAVVHLPFPSSPPSSPTTLATLIPFLAFIERMIQPATRIPRGAAREQLNPRPPSFIPLHVQTSVPPAFGPSSLPPPSAFPKSFFDKDEPAAAYTRVRSTSATFLPSSPSPSTSSSSSDGHSSPSTAPTSRHPSASSSQGPIAPMELRTRPLKILIYSADGYTESSVLALCLLMALRGISLPEAYLVLQVEKRRSFFVYPNDLSVLRRVEQRLEKDRAARDARARTGLLGGRQCESPTTGGNVQNCKAGEEGSRPAGLSVSFAPAPAQDPPLSALSIVTAEQATHSPGHGRHLLRAMSESDAGALVPGGPSQSHLGRPRASTLPLPISPSAGDHHLWFDDPRFEGSFPSRVLPFLYLGNLNHASNVFMLHALGITHVVSVGECALVPPPNLEASACGAPSSPSSGAHFVPGKGPGGHGSLWIEEREGRIKVLDIKGVCDDGIDTLEPQLEPICQWIDRAREEGGKVLVHCRVGVSRSATVTIAYVMKHLNLPLVDAYLIVRSRRLSVLIQPNMRLLYNLLGWEVKLARERAGEDPDRLRAELARALNWPYLAKEVHALNEKYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H172</accession>
    <name>A0A401H172_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1204170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619099.1">
        <property type="nucleotide sequence ID" value="XM_027763298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H172"/>
    <dbReference type="GeneID" id="38785103"/>
    <dbReference type="InParanoid" id="A0A401H172"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="130" mass="14129" checksum="43357C7CA2234F45" modified="2019-05-08" version="1">MTRKIQKLSSSRLLSDASMQEHSSTGIALMKNFKMAAKTSCLGLQICCVQGSWAHYGGLFFKITHADLQNLDAAASLGLDHYTAAVRQSAGIKVYCEDKFGALVFLAFCLLVGVLIRGGGKSKYTQDYQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1B4</accession>
    <name>A0A401H1B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1204000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619083.1">
        <property type="nucleotide sequence ID" value="XM_027763282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1B4"/>
    <dbReference type="FunCoup" id="A0A401H1B4">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1B4"/>
    <dbReference type="GeneID" id="38785087"/>
    <dbReference type="InParanoid" id="A0A401H1B4"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF162">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="399" mass="43250" checksum="BB449E308F08457E" modified="2019-05-08" version="1">MFFYLSFLRPPPLQTSPSGSISITPQIANDLRTELFAGEQDIYYAWSADTPPNGRASTFPCISKPQKLTTWRKSSAYKELAVPLPPGIREGQSFRLVLTAHSSGNPHVVNLAGATLGERPFPVLSMPILFSSRLSAKAGSSTMGKQEQVERVYRIAAGSGDQLFLHVKEQTSFDLDKKVWDSGIGLSSWIASLAQARPSDSAPLVDNLLDILMSREPRNIVELGAGTGIVSLTVGALRAAIPSSSNGGCILTTDLPSAMPLLVHNIAENEALFRSTSTRPRALVLDWDDEQLPNEVSAVVSDLDLILMADVTYNTSSFPSLVRTLSALTGAHREQAGDETGIATRLKSPSILLGYKERDSSERILWNMVREIGIVFEQVGERVGSGGEAVEFWIGHVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1S2</accession>
    <name>A0A401H1S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1301790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619277.1">
        <property type="nucleotide sequence ID" value="XM_027763476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1S2"/>
    <dbReference type="STRING" id="139825.A0A401H1S2"/>
    <dbReference type="GeneID" id="38785281"/>
    <dbReference type="InParanoid" id="A0A401H1S2"/>
    <dbReference type="OrthoDB" id="2797051at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fatty acid synthase beta subunit AflB /Fas1-like central" evidence="2">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid synthase meander beta sheet" evidence="3">
        <location>
            <begin position="344"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="4">
        <location>
            <begin position="511"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="651" mass="73012" checksum="85FAAE2455245148" modified="2019-05-08" version="1">MPFDGFLFASRVMVAKEAHTSSSVKDLIVAAKGVDDAQWEGTYAKETGGILTVRSELGEPIHKIANRAVKLWKEFDNTVFNLPKEKRAAWLVEHRSEVIAKLNKDFSKPWFGWKKDGSVTEDITDMTYEEVAMRMVWLMYVAKEERWVDLSLRNLTGDWLRRVEEHFAGVNGGGEKSSILQSFNSLDKPQAVIEEFFKTYPLATEQLLASEDKAYFLTIVQRPGQKPVPFIPVLDASFEVWFKKDSLWAAEDIEAVFDQDPQRVCILQGPVAVKHSKAKDEPIKEMLDNITLLLVKKLIDRLYGSDISKIPTVDYLSPGPSALATPLHVERSVSRNTITYKLGQILPETSSWLETLAGPELCWVRALLMSPTVVQGVLYIDNPIRCLFAPHQGQKVVIETDGVSPIGISVYGAARSYGAHKSDFKAVDVKYNTYSRTINFTVYEDCRDVAIPLKLQFVHKPSMGFALIHEVTTDRNHRIKEFYWKLWLGPEENLPEIDLHATFTSPEVTMDADKIEVFCSVIGNDGEAFKTVRAENVQAPMDFAIVTGWQAIIKVIFPSTIDGDLLTLVHLSNGFRLVDDAKPLQASDVCKIEARIVSVINSDAGKTVRVLKASLSEMASPSSRLCLLSYTVVAIPDMTTRSSFSRLRITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1T5</accession>
    <name>A0A401H1T5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase cytochrome B subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1302060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619304.1">
        <property type="nucleotide sequence ID" value="XM_027763503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1T5"/>
    <dbReference type="FunCoup" id="A0A401H1T5">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1T5"/>
    <dbReference type="GeneID" id="38785308"/>
    <dbReference type="InParanoid" id="A0A401H1T5"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE88391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="177" mass="19122" checksum="CBC579298EB99003" modified="2019-05-08" version="1">MLSTRTIGLGPALRRAVLKPRHGQTQALRAIFPKRSVQTQSLPPSASVDILNKQRLNRPSSPHFAIYQPQLTWLGSIANRVTGAGLSVLLYAYAIAYLVAPTTFDSTHVIEFVAAAPDAVKYAAKTVLALPFAFHSFNGLRHLSWDMGKFLTLKGAYNTGYAVLGATAVSTIALVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1V1</accession>
    <name>A0A401H1V1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1302320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619330.1">
        <property type="nucleotide sequence ID" value="XM_027763529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1V1"/>
    <dbReference type="STRING" id="139825.A0A401H1V1"/>
    <dbReference type="GeneID" id="38785334"/>
    <dbReference type="InParanoid" id="A0A401H1V1"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1132" mass="121192" checksum="B230192DB31E8590" modified="2019-05-08" version="1">MALQTRLDPMNASPYHPKVRVSLKLAEPLFVAGSTITGKMEVECKADKGLGIGVIMAELFAIEELTSRDHSATSTFLHPRRLFQGPGLPPSNAVHPHPTPGDPPLPCHHYPARRGVTTFLFQFSLPESSPSSINFGSSLANVRYEIRASVSVAWKGQKSFVMDKKLVDVVECFEKDHSRMTVPEGLIVGENGKIWVQGKVVGGFMVAGQPACIELQVKNHSAKKNTGLAVSLTRQLHLSSLASSQKQLLQISDTLTSVSFRGAEYIIQAGAEGVANLVVDVPKAARGVKGGKRRGNDESDSTTEPLFEVRCIVSVKLSMGIGSKDVRLDLPVMILHPLALSTVPFPDPYSVSPQPYNGLIYDPMPLTLYQPSTSPASYQQYPISSYPSPPTSPFALPYLHQGQVWLPPPSAGPFSPPPVSYPYYHSDPVMSYIPPLRPTSAEPIPSQPLYGLPTSYVQQPLPSLSLNQPIAEREEGKGERASRITLHLRMSSRHRSASPPSHRFAIPVSSDPHTPPTPPTLSLPVERLTLKAYSSYSPSSSPHSRPRLQPPPLDLPTSPACAQGLVVSPRPMLSPKHSFSVDPVAQVTHIENLERIAARVDSHNADMSVSGAELDLGPNNCTGHENTADRDKTLPSPPVSTDKDGVAQVRTKLDSLFPEETPTPPTPTLAAVTSLKVPCVNSAHAGGLDLIGGVSGLDALEAKLLAEVGTRKIEKAAHYADVRSVLPISIPRSTDQQDPAVDSAISSLTLPALGSEPRTLKREEPIHQREIGEDAKSESKKAEIQGSNKDGGSRKHGGERANHSKDDEFYRLRKAAQGRVAAWLGSIEPDVFPQATSPPTSLETVLPAQDGERSEGDAEALQDLSKNVSPDAASPDVSAAPNPRSSGFLPIGTIRSNIQVPIPTGNVNARNSGKDSPNPKTPLARVAVVPPRLAAYPLQPPDPEVRYDIRSARGGRGGKVTAVAAIWASATQQQDNNSKPVVKHSGVSLAKTLDLGKTPTMKPLPQKSLPLSEPPKPPSNAKLSLAPIRPRETKAAPAVDISAKRGRMTKASTSPAAVSSSLATPMLSSTASLARPTPPLSDRNNLKLPTSIPEMSRLKPSDPKPNTAKGELAFGQARLRELIKRYQGQTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Z6</accession>
    <name>A0A401H1Z6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1301950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619293.1">
        <property type="nucleotide sequence ID" value="XM_027763492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1Z6"/>
    <dbReference type="STRING" id="139825.A0A401H1Z6"/>
    <dbReference type="GeneID" id="38785297"/>
    <dbReference type="InParanoid" id="A0A401H1Z6"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF107">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="627" mass="70822" checksum="54148DCC3DD83395" modified="2019-05-08" version="1">MATSSGTRTARPRSSTGSKPTLPRLPVPDLHQTLEKYVRSLEPFLLEDASSGGSSYDSAHSLRLKWAEDFESSLGKICQERLLLLDRVSPHNWLDDNFWLKKAYHEWRAPLLVNSNWWLAFHNDPTIPEDVILGLCDATKTGTTHWQVRRAAWLVYRVLDFKIRLERQELHPNTTRAGIWLQETTAKIWNRCRLPQPQCDTFTSLPKTSIPEARTLLVALHDWFYVLEVLDESFQPIRPGEIESKLRAIVADVEDRLARGERAVPVGVLSADDRDIWAENLCHLLALSPINHDVFRAISQSIFALSLDPYTYVLPSSPNRPNLLPATCTASEVTAHLHNVRSAHTEHPAHNRWFDKPFTLIVESNTRAGAMGEHSPCDALVPSIVAEYAVVQALDERAFASEDANATANGWERLDWIVDERIQRECVAAEERAREIVDDSDDGFLWYGRYGADWIKNVARLAPDAYVQMALQLAWFRSRGSFTATYETALTRLFQNGRTETIRTLTTDSRAFVLAMVDPEASSDTRHRLLSRAVQTHTNLTRLAATGRGIDRHLLGLQQMLLDGESHALLEDDLFVRSQTWKLSTSGLSTGHQFRGTGFGAPYNDGYGINCKLGPCDSDLRDDWVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H236</accession>
    <name>A0A401H236_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1302670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619365.1">
        <property type="nucleotide sequence ID" value="XM_027763564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H236"/>
    <dbReference type="FunCoup" id="A0A401H236">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H236"/>
    <dbReference type="GeneID" id="38785369"/>
    <dbReference type="InParanoid" id="A0A401H236"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000002">
        <property type="entry name" value="Pre-mRNA processing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE88452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="358" mass="41329" checksum="B98FC77F90A459FB" modified="2019-05-08" version="1">MDALKAEIATKRKALEQEPTTNGPRPTKYMRRGELERLREENERKEKEEKGEKERQENGQAEGRVTASSSRAHTDSPAPAPGTNASASPAPESRLSFNISNEETIRRLRAKGQPVRLFGESDKDRRLRLRALELIEEKDHERHGGQNDFKKALEDVENVERLMRDRRAQEEEGRDKGKKRESREGSGSDVLDLELIRTDPDKLYPVIYYALKRTLKEWEEWMDERPEHVKRTTQGKLAAATQRQSAEYLKPLFKLLRSRSLPADMLIRVAEIVHHMQKRQYQKANDSYLRLSIGNAPWPIGVTMVGIHERSAREKISADQVAHVLNDEVSRKYIQSLKRLLTFSQTKYPPEDVTQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H245</accession>
    <name>A0A401H245_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1302450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 8"/>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619343.1">
        <property type="nucleotide sequence ID" value="XM_027763542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H245"/>
    <dbReference type="FunCoup" id="A0A401H245">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H245"/>
    <dbReference type="GeneID" id="38785347"/>
    <dbReference type="InParanoid" id="A0A401H245"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00570">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003704">
        <property type="entry name" value="PRK05321.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="173"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="412" mass="46528" checksum="C70C0D1D80FA8332" modified="2019-05-08" version="1">MSGQVVLPASILDTDLYKLTMQQAVLHHFPDVQATYHFTHRDKNVFFTRECIQQFQLSISKFGDLQLSDSERVWLKATCPYFTDNYLDFLSAYRFKVDQVQVHFIPLPDDAAFGHLEIEASGSWVDTIMWEVPLMACLSEIYFRMVDTDWSYDGQEESAYRKGQTLLAAGCIFSEFGTRRRRSYHTQDIVVGGLLRAAKSTDSGKLLGTSNVHLAHKYNLMPVGTIAHEWFMGIGALKGYEHANWLALSLWEQVYPHDLLLALTDTFSTEAFYKDFIQHPEEARRWTGLRQDSGDPFVFAPRAREVYQQLGINLHDKTIIFSDALNVDKALKLKKQCDELGINASFGIGTSLTNDFKSLSSGGAAQSRALNMVIKLAAVNSRPCVKISDELTKNTGDPKTVRLVKNIFGINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2D8</accession>
    <name>A0A401H2D8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1304010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619497.1">
        <property type="nucleotide sequence ID" value="XM_027763696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2D8"/>
    <dbReference type="STRING" id="139825.A0A401H2D8"/>
    <dbReference type="GeneID" id="38785501"/>
    <dbReference type="InParanoid" id="A0A401H2D8"/>
    <dbReference type="OrthoDB" id="2507647at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="464" mass="49885" checksum="56CF3D7F8B64A7B3" modified="2019-05-08" version="1">MAPTAGRSRLVSPPPPPAQRSSRPPVPPVPRHLAGQGSFPAHLSRRHHGGLPPVIAANPEPLPFESLFDHLPHRHHTPPVHAPPAAARSHHQPVMGLGGALIALNRDAVAEANSQEERRRAMPEREEPPRSPSQGRARRTRAPWADNTIIPYDDFLPVQSIDDGFFDWAGADYPLRSGRTGGLDEPKYYKPTYTHPDKPMPGFTFDFAPAEMLSSSGASSPTVIVLDDDEAVSSSGATTGSASTSSSTTAVETTLVCAQCLDPLVRGALTEDQRKMGRIWVLRCGHIVDGKCIEELMHPATQELVGEEVESKGKAKAEPEDAAPMEPLVQDRKGKGKATGISDLSSMPAVPELEVAENSIRSRLRSRRPPASLKVGTTGAASESARHPPGRLARILPRRRQHPATPAHAKGKGKGRARRAHKPAIEAEHSWVCPVAGCGHVHVSICVDGVWKMDEERGAIAAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2E5</accession>
    <name>A0A401H2E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1303950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619491.1">
        <property type="nucleotide sequence ID" value="XM_027763690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2E5"/>
    <dbReference type="FunCoup" id="A0A401H2E5">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2E5"/>
    <dbReference type="GeneID" id="38785495"/>
    <dbReference type="InParanoid" id="A0A401H2E5"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="397"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE88578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="471" mass="52621" checksum="D39D24BB0D5190BB" modified="2019-05-08" version="1">MPSVQPQPNLDTPSDEDEGSHILLTFLQSQSQNTLSRLYQRPSSCLSIFRLLRPLERQLITNLLWLESAIPVSTMGAWVTRDGRKAYNLCLTTLAHLNILPTSTVKLALNSTLKSSLRQAITGGGSSGSFGVPAEHDQQHSPPSVDDLDAYALERWETILHYMVSSGTGQYPAKPSQDVLFLLQRSGLMAKANGALQITSSGFQFLLHPPHAQLWELLLQYLHMAEERHMDLVEILSFLLMLSTMELGREYSIENLSVTQMAMLSDLRDYGLIWQRNATSKRFCPSRLATTLTSSSPPLPTSSGAGTASNTQGFIVLETNYRLYAYTDNPLQIAVLNLFVTLKSRFPNLVIGAITRESVKKALANGITADQIISYLTTHAHPQMRKNNPLLPVTVQDQIRLWELEKNRVNSEEGYLYTAFASQADYEYVLNYAKQLDVVLWESPARRCFFGSLNGHANIRGFIERRTAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H306</accession>
    <name>A0A401H306_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multifunctional cytochrome P450 monooxygenase af510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1401550</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619663.1">
        <property type="nucleotide sequence ID" value="XM_027763862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H306"/>
    <dbReference type="STRING" id="139825.A0A401H306"/>
    <dbReference type="GeneID" id="38785667"/>
    <dbReference type="InParanoid" id="A0A401H306"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE88750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="514" mass="57542" checksum="558051A4F9CD9A27" modified="2019-05-08" version="1">MSYLLLIACLVLGAIYVVSLKFLRRDISSLPPGPPGLPVIGNVLDIPADRPTWLTFADWAKKYGDIVHISLLGQSSVILSSPEIIYELFDRRGAIYSDRPSLPMAGDLVGYVDSVPLCPYGSRHREYRRMMSTGSVLSPRKASELYPVQEQKSRELLMRIMNSQAQLRSQLRWVIAAIVFQISHGYTVLDMNDPLVQLAEQANHEFALSTIPGAYLVDVLPILRYVPDWLPGVHFKTQANQWRRTTERLRDEAYESVKAQVAEGTAAPSFTTTILEENPRLRDEDDIVLRWASTSFYSAGADTSVSALESFFLAMSLYPDVQRTAQAEIHQVVGPSRLPGFVDRPNLPYVEALLNEVHRWNPVAPLALPHRLIRDDVIDDYLLPAGSTVFANNWAILHDPVRYPDPFKFMPERYLANNSDGINPEPTKFTFGYGRRVCPGQGLADTSLFIIIARILAVFDVSKAVDPRGMLIEPNEDYTTGMISHPKTLDCRVAPRSADAERLISGYGHGSKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H398</accession>
    <name>A0A401H398_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GCM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1403230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619828.1">
        <property type="nucleotide sequence ID" value="XM_027764027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H398"/>
    <dbReference type="STRING" id="139825.A0A401H398"/>
    <dbReference type="GeneID" id="38785832"/>
    <dbReference type="InParanoid" id="A0A401H398"/>
    <dbReference type="OrthoDB" id="2799524at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036115">
        <property type="entry name" value="GCM_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90073">
        <property type="entry name" value="GCM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49304" checksum="061D186EA1F890D6" modified="2019-05-08" version="1">MPGFNAHQSSLPYSDIPFAPDAHPTNILNHTPVIQEAHFGGHQSGAIYPAADGTEPDHNASPRDLGTLHAHSSTPFPFSMQTPYPPSFPPYAVFPPPFMPYPSYTPHISYWPPSLPRNDVHGERQRPGGTQPHSGEASRDLVGERTTSEKCHVSEADKIVDALDWPSSSVRREEPINMDDKKWKQTKWQWRSQGNRPSKGGAEVRVCLGVFQCITCLYLIWPKMDPAQRQIQLQQGCRNPRCRDSKLVLHACQAKVFHYRVTRDGQEFLVWEHEGEHAHPRPPGVPLSKAEEVAFDAQVLRRPGASAHELRTRDTAPDSVPLAEITPVLANPRAARYEMSKSHAHLGLLPAAGKGAFGVLHSLGSLNEKLKQEFIINSSFTGPTFFIMQTEFMKQIITDSVEDWILLAAGGPDAGHHGFVTDADQSFFRDGHLIVTCTFSTVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3W5</accession>
    <name>A0A401H3W5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1500940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620004.1">
        <property type="nucleotide sequence ID" value="XM_027764203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3W5"/>
    <dbReference type="STRING" id="139825.A0A401H3W5"/>
    <dbReference type="GeneID" id="38786008"/>
    <dbReference type="InParanoid" id="A0A401H3W5"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="280"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1061" mass="115301" checksum="F0ECFFA1D6FC422C" modified="2019-05-08" version="1">MSDSSFPATSTPPLFSTTSTPPSSSSSSSMHTPSPNLEQRELSSDSSDPLSFLLQSLGETTDNAQDWSSLSSWTHADAKFNELSSDFNFSLPMDLDFDANMAVDPHTLHFSSMMDQSSLGLPPPENSFLMADGDMFFSPAGEQKWHTEFQGGPARRLSVTSSSSSSGASLSPGLDSASVTSSSPPSECNLSDPAQELAQRVREMAGVMLAVPVSAQVQQLAAAGGQSKLPIPRLVRQNSSLAASKRGSPKPDSFTLPSGKVESPGADLTLAPPATSVIGRPKTSHTTIERRYRTNLNARITGLKQAVPALRVLEAKNGGGLNVHNDIVDARGFVDGVKVARKMSKANVLGKATEYIRVLKKREARFRHEQDGLKSLIAGLVGGPALLKEWEREWRMRFGGEEKDEIEDDDADAGSGDEDGDGEDSEGEDGEGRSRKKAKLAKQVKKEKLSRPVLPPLIPATPGVVPEKRKRGRPRKNPLPAVMSALASGGASLPAQPTEPPNFSTTQPVQAALMQPQEGVTAQPAPAQQYLLAVFAFFSVFNTPLMSSTRSHANSSPAAHHGIVLTPHIPAQSQSPTPSVTDMSSYSWHDVVQAVHLLISTLVFFYVIVPWLSGALRATSVRARVSAYFAFHRIWPATADEAKTDSVKSSSEPKPTDDVKSPKSKFYNRAALMDALAPAKRGSEDEATRLRAALSVSDGFIGLLQGVIKAGRVDRGIELNQLEQRAWVRLGELVAFNREVCNTTRVQTYWCMSWHISTFSASATDLSTLALIMRPVSHSKAAALWESAREREIVRADERLALESMSVDDAAEWLEKWRLWHVSERKGRCAACEKRTPLGILAAILIRERLRKHAAALFVRTVVREGRCPAEERDCDGDGEYEYVYDAEKDASEEQERRETISAGKSIGGRTAELAMSLERIWNTGFCSQDLLPPHRPHAYEDADADEDCEDEQDLASTDEAEVRALLSATIAYRRIFPSSIPACSTGVPFVLSPPPSPSQRNAALHMALRTALGSPAFEFGGGRLADEQLGAALEDARDRVVDMLVERERAFRRGGRTSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Y7</accession>
    <name>A0A401H3Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase yakc [NADP(+)]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1501620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620068.1">
        <property type="nucleotide sequence ID" value="XM_027764267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Y7"/>
    <dbReference type="FunCoup" id="A0A401H3Y7">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3Y7"/>
    <dbReference type="GeneID" id="38786072"/>
    <dbReference type="InParanoid" id="A0A401H3Y7"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="286" mass="31682" checksum="17F42AFA6A435743" modified="2019-05-08" version="1">MWDTANVYQDSEVLLGKWFKRTGKRNEIFLATKFGVFNSGGRTINGDPEYVHQAFETSLKRLGVDKVELYYLHRPDPTVPIERTVGAMAELVKAGKVKYLGLSECSADTLRRAHAVHPISALQVEYSPFTLDIEDEKIGLLKTARELGVTIIAYSPLGRGLITGKYRSPDDFDEDDARRKVPRYSKENFPNILKLADGLKRIGDRHGATAGQVSLAWLLAQGPDVIPIPGTTKIPSLKENLDAAKLTLTREEVQEVRDIAKVANAANGPRYRPALEAVLFADTPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H510</accession>
    <name>A0A401H510_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ESCRT-II complex vps25 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1601800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620431.1">
        <property type="nucleotide sequence ID" value="XM_027764630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H510"/>
    <dbReference type="STRING" id="139825.A0A401H510"/>
    <dbReference type="GeneID" id="38786435"/>
    <dbReference type="InParanoid" id="A0A401H510"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="201" mass="22731" checksum="E367DC76D492D1B3" modified="2019-05-08" version="1">MVSNFRGGTTLSKHTTLSGFLLPSIHSAPPFFTQQPNPTTEAIVVQQWSRLILAYARHRKLFTLRVEDAEIVGSEWDEILRNDRINRRLLPPHLEFILTDMVTKNTAVYEPPRQTRSVLLYWRQPEEWAEVLHDWASTTGQLNTILTFYDIIEPPVSSPLSGIPMVILRKAISILTKTNRAQVIAVADGEGVRFLAGNSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5U4</accession>
    <name>A0A401H5U4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1701190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620707.1">
        <property type="nucleotide sequence ID" value="XM_027764906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5U4"/>
    <dbReference type="STRING" id="139825.A0A401H5U4"/>
    <dbReference type="GeneID" id="38786711"/>
    <dbReference type="InParanoid" id="A0A401H5U4"/>
    <dbReference type="OrthoDB" id="3267098at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="482" mass="54652" checksum="096604E7ADF0CDF0" modified="2019-05-08" version="1">MGKSQNHPVYIPDFVRRNTGDPATKDFVAKLKKHLLPRIKAMIGREATFSGQEQSPLVPVIENNSARRDHDSVFFKGDHMYEHHILKVNYTTYNVRRSHDIINPSTDNQDILLLARFDDPEDATSMHPFLYARVLGIYHVNVVYTGTGMADYTPRRLDFLWVRWFQYVGDSTNWSQHKLDTVEFPPMADEETFRFIDPDDVLRACHIIPTFKGGKIHADEIGLSHCANDAEDWRFYHVNRFVDWDMLMRYHRGLGIGHVHADGPTPIVLSAVCTNPLEGSNDISDSGMSVDVEGDGLSSAPPDGILQAEGEDSDDDNLELTLENLEDDMWDSDKSAMLHKSRLKAALHNCIRRSIEKGLSPSHPGLGDCTSEHSACREHPSSSTAEHDHLLRVLFAVGLPNTACIIAVDVNVCMLQRVSGHYFIMLYMSYLECKRILDALKIYQSGGREYPYIYHLSQGFVYEDMMPLSDSGRVNGDRVRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5V9</accession>
    <name>A0A401H5V9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620682.1">
        <property type="nucleotide sequence ID" value="XM_027764881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5V9"/>
    <dbReference type="STRING" id="139825.A0A401H5V9"/>
    <dbReference type="GeneID" id="38786686"/>
    <dbReference type="InParanoid" id="A0A401H5V9"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="28824" checksum="32C7B6A8909F9037" modified="2019-05-08" version="1">MERTIGNLGEEIKQPSNPYANLSQRGLRRSQVNAVKIMVPHLGVLGEKDNSQDEKTVQLNSGYNLRHPRQKAGQHIRAVGEVNAIRRYMIDHGLLTSMAAKDWDPKLAKWARLGLPNGQIARSVYGESKRTDENVRMSCNVKLDINGTTHFGEVQYYFQAETGHAQSSALAVIRLYSEPDAIILQRSYNTVWMCHPQGDAALMVVDIENIIAVVGMIPEPFYGGAGAGEQAERSDRFFVVEKTGLEVGLMAGELQSVEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6U6</accession>
    <name>A0A401H6U6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1900160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621080.1">
        <property type="nucleotide sequence ID" value="XM_027765279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6U6"/>
    <dbReference type="STRING" id="139825.A0A401H6U6"/>
    <dbReference type="GeneID" id="38787084"/>
    <dbReference type="InParanoid" id="A0A401H6U6"/>
    <dbReference type="OrthoDB" id="2793270at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41210" checksum="14DF3002F1AFB7BF" modified="2019-05-08" version="1">MVKELPMELIDNIVDHLWDDKPSLCRCALVSPTWLRTSRYHLYRGNACLSSSKNLESLVAASKVSHVAASLRSMGSLCLEDGDPAWVHRFPLVLGRVLSEIQELHIFRLTWEVVVMHPDTLTIGLMQFHRVTQLGLFDCSFRNFRQLQRLICALPQLRDLRISRVSSKKPSLLAAESMFRPPPLTDVFLYNIVDQLLASDFLDCLVYPSSVTLRSLRLEVPRKLIPRVVTVLDAAKPSLEHLHLILEESVSASDLVELDVRRCTALRRLDLTYVHRMSLADILRLVPDSGIGQLWISMRPGSVKREWQSASNILGEKRFSKLHEFGIRILDESLSEEEKQQIKDGFEVLRGRGVKVVMHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6X4</accession>
    <name>A0A401H6X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1900340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621098.1">
        <property type="nucleotide sequence ID" value="XM_027765297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6X4"/>
    <dbReference type="GeneID" id="38787102"/>
    <dbReference type="InParanoid" id="A0A401H6X4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="91" mass="10075" checksum="7181F2FF1E55012E" modified="2019-05-08" version="1">MVILCSGVNCAGTCDFLTGPDQNVCYSIPLNNNVSEYGSIMAYVCFYCLSTYQVYMATAGCAESVQLEHNVCYNTSYDGMLGYYQTFYILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5E5</accession>
    <name>A0A401G5E5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0102580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608298.1">
        <property type="nucleotide sequence ID" value="XM_027752497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5E5"/>
    <dbReference type="GeneID" id="38774302"/>
    <dbReference type="InParanoid" id="A0A401G5E5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="91" mass="9987" checksum="ECAC01E52E396869" modified="2019-05-08" version="1">MGSRSDDRAGANAVGLMCQYESVRTEKSTVGPPESALGCRFVVSRSDAVKARLSGWRTADELNEACLTDGKARWETRRLALEIYKVAGMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G684</accession>
    <name>A0A401G684_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytosolic Fe-S cluster assembly factor CFD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0105540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608586.1">
        <property type="nucleotide sequence ID" value="XM_027752785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G684"/>
    <dbReference type="STRING" id="139825.A0A401G684"/>
    <dbReference type="GeneID" id="38774590"/>
    <dbReference type="InParanoid" id="A0A401G684"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001119">
        <property type="entry name" value="Iron-sulfur cluster carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE77673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="308" mass="33117" checksum="868E87E0A21C31B2" modified="2019-05-08" version="1">MAAVEDTPVARRLRHVKHIIIVCSGKGGVGKSSVSTQLALSLRASSPTARVGVLDVDLTGPSIPRMLGLDGHPVHQSSDGWVPVYADGSAARLACMSVGFLLKRKEDSVVWRGPKKNAMIRQFLSDVRWGDLDYLVIDTPPGTSDEHLSLVEHMAPVHSRISAVIVTTPQAVALLDAMKCLSFTRTTSIPLLGLIENMSGYVCPCCGEISNVFSTGGGKEMARREGLTFLGSLPVDTELVSLLDATQTEDTASAEDIADSGSHQSFELLYRYQKTSTAPLFKAITDKILQTFSNEEYAGDMGVIDIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6P0</accession>
    <name>A0A401G6P0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0587 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0106990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608730.1">
        <property type="nucleotide sequence ID" value="XM_027752929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6P0"/>
    <dbReference type="FunCoup" id="A0A401G6P0">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="GeneID" id="38774734"/>
    <dbReference type="InParanoid" id="A0A401G6P0"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="18153" checksum="1BD7B9D32B78E95B" modified="2019-05-08" version="1">MVHLTLSIKADLENVTDLVPASDAFEYFFQVKCTSCNEVHPKFVSVNRQEERELSSGKRNKAHFVWRCGLCKRESSAKFEPGAVPQSYSADVNGQFAPLITLDCRGLEFVGFDPRGIWKCVGIESGTVFNEVDLDEGEWVDYDERAALPVGVSNIESTWNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6W4</accession>
    <name>A0A401G6W4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0107870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608818.1">
        <property type="nucleotide sequence ID" value="XM_027753017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6W4"/>
    <dbReference type="GeneID" id="38774822"/>
    <dbReference type="InParanoid" id="A0A401G6W4"/>
    <dbReference type="OrthoDB" id="3226059at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23940" checksum="510867FD066EE9DC" modified="2019-05-08" version="1">MHSGLPYHARLHTSALYLAYPFDRTLFAIVPLASLSASPSSPPPEPGPLKMRQRRSTHRANCHPYLFTLITLTAMAELGLTAFLISAGSEIHTWASPGYYSLLILLCVEAAWTLLFAGAYVLWVVDGAVHVLANVASSVIWLLLTSILWGAGTGLIHGNRISSNCPEHAPLSRCRQTMTVEALGWTEFGLCCLTLSATILWLRTGLGKRNHVKDSRTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7H9</accession>
    <name>A0A401G7H9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tetra-spanning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0110130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609043.1">
        <property type="nucleotide sequence ID" value="XM_027753242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7H9"/>
    <dbReference type="FunCoup" id="A0A401G7H9">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7H9"/>
    <dbReference type="GeneID" id="38775047"/>
    <dbReference type="InParanoid" id="A0A401G7H9"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="259" mass="29215" checksum="61FC6F202210ECA3" modified="2019-05-08" version="1">MATTQHYMWAGGHFILLISSLRYFLAAILFRAVSAWWYKTAFIGALVSYTIVCEKQYANERERLPPVLSLAFARRVLMEENVQYLLLAIFWWSSKPVAVALIPYAIFSLFHALTFTRTTLMPQLLASGPPATAGGPPTPPALAKKLHLWVKANYDTAMRVVAYAELLIMLRVTLGALLWQNSLMSPLFYAHFLRQRYYQSKFTRESLSFINDYVEGYVRKEGTPALVVRVWDSFKLVLTRWGGTVLAPQGGAGAGPRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7W3</accession>
    <name>A0A401G7W3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0111530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609183.1">
        <property type="nucleotide sequence ID" value="XM_027753382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7W3"/>
    <dbReference type="STRING" id="139825.A0A401G7W3"/>
    <dbReference type="GeneID" id="38775187"/>
    <dbReference type="InParanoid" id="A0A401G7W3"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="301"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="380"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="679"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE78270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="742" mass="82643" checksum="A15BB17780B0DB25" modified="2019-05-08" version="1">MNTLSPTSPKVRRKVSSRRPRAVSHLPPYTQDSHDAALYSIRNYLKGRTTYDSFPVSFRLIVLDSKLEVRKALQCLLLNGVVSAPLWNSEKSCFAGMFTVSDIIHLIQYYYQFASYDVAASDVETFRLESLRDIEKSLGVATPPLLHAYPSATLYDAARLLIQTHARRVPLLDEDTETGHEVIVSILTQYRLLKFISINCGKEIQQLHLGLRKLKIGTYVEDPSALPPDAQRFHPIATATLSTPVFDVVHMFSARGISAVPIIDADGIVVNLYETVDVITLVRLGAYQSLDLTISEALNQRSPDFPGVVICTASDSLGTLMQLIKRRRVHRLVVVEGEEEERKGGKKGRLLGIITLSDVLRHRAVDSCCYVLCSVFTMAAAIQAIHVRSYEERYEPKAHTVYRIEIQASVRSWQMWRRYSEFVDLHVELTKSTGSVPPCQLPPKRSLTMFKSRSSPALLEERRAGLELYLRAILSAKEDRWRESFAFRDFLGVPVGKLLPQGGDAGAPAQFTSSSWLDEHQDLQARVRDVRADINKRDALADRSDVAGAHQANVQAKKKLAGALSRVGVLEDGLRTLGLSGMSEGELQRRTDMVARLRDDCEKLAKMVTVARMTSRGLGSNAERNPASLSDRAALLETSSTSSSGFAPPVTRVFGEAAKPQETQETRPLDNHGLLQLQETQISHQDEQLVQLSTVLQRQKHLGLAIGHEIAEQTEMLDDLTTEVDRTGRKLTGAKKQMNRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G852</accession>
    <name>A0A401G852_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0112360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609264.1">
        <property type="nucleotide sequence ID" value="XM_027753463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G852"/>
    <dbReference type="GeneID" id="38775268"/>
    <dbReference type="InParanoid" id="A0A401G852"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="196" mass="21845" checksum="2815EDAF62A20D56" modified="2019-05-08" version="1">MDASIILRKYTLAEALLCIEIFTEPFDPILWKAWAVRMHVLLVLMVQAQSEAASVGIILPLPRDIPVLAQVEIHLAPARTVEGGHRMIPRIADHLPAVIPHGLTARVLYDDPAVREDFGLGHLPDGLPDIGTLHLRVETLRNMAHELYDVMRGITGRCELADGTLRRLQITVEELEVAFRLVAFPPPITSFQLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8B1</accession>
    <name>A0A401G8B1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0112990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609324.1">
        <property type="nucleotide sequence ID" value="XM_027753523.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G8B1">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="38775328"/>
    <dbReference type="InParanoid" id="A0A401G8B1"/>
    <dbReference type="OrthoDB" id="68020at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2521"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2546"/>
            <end position="2565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2600"/>
            <end position="2620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2641"/>
            <end position="2667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2687"/>
            <end position="2707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2714"/>
            <end position="2735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="2747"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="8">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="9">
        <location>
            <begin position="1584"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="733"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="888"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1552"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2323"/>
            <end position="2342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2350"/>
            <end position="2439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2855"/>
            <end position="2902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="921"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1553"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2323"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2350"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2419"/>
            <end position="2436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2881"/>
            <end position="2896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2902" mass="318591" checksum="F5546697900D812C" modified="2019-05-08" version="1">MDELVRHCLRELSFDGDLGCNVSRLHEFVNGFYSRSSSSPRQNIDDAYCAFIWSVIVQQPGVRVGTIPPGSATEVYIAPQTSAKRKAKAKGEELEDPLLPTTLDIIPDAMIRSLEDLTNEYGDGLRIAVNPEISFSAITGSHIRPSKLTPMVYTVLQFITRGREDGISVVDLGKKSGYDQKSCFYLVKQLLDLDLIVKKRRPGVSTNFCVHKYFFEHSPIWKKIVEEEMKANESEEEQDDDDTQMGPSSSDVEFSAIDSRHLSSLPLVRARIAKLLKNSPHHLHASQNLLLKIGFANPTKSDRRFFRSRIRDLIDQGVIEKVQVPHVHFPNRKVTCVHLIAPDEPPEGDKEIPLSGDAEHIVSGELEPTELKMNLTLHKQMINLLDVAGTTGMTLSELSNALCDFDRRTVELLLSRLEKDPPPLHLSDLGVAQLGETHGREKRYKYYTVAHYRTIATREKFEESRYLDVDCSSVGTFLPVDDKLFYKDEDTLNNYVDSFKRKSGLGGSDASSAKKSKKRKSVADARGGDESTHVTKGKKRKRADADVDVVNDSDAGEEPPLKRKRGGPQKKRPSVEGDGPGSQVGDQSDMPVPKKRGRPPKKSITATNLIHPSAETESSGQQGDVPQEMPVPKKRGRPPKKKSVAGAGQSGDLPNTVPKKRGRLPKAKPAESDADVAVTDDILMVDAAKPSTLDASSLQEPSALHLNDALPTADNDVSMQDGVSVHVTEAAGPSIAACENNSTGPLESRDSVSSNAVSTTPLRHSSRKPKPRHLSIERSPLREPSPSKGPGVRSQATLQEHPVDVDADDEAHQVEGDSLHGDPPAARAGLEIVTQHDHFLPPAASLVVSASVPTIEVPIDPRLTGEGGPLDAHTDVQATNGESTLAVVGADAPNPMQDITSKRTHPDTSSPEPLAKRPRTNEPQTSSVTGFRSKANISQSRRESEILRVISDFGGIVNTSSKEFLEAHAAVVQAITKSGGVASTRPGARLDKRTVEATLKGLESRHKIKILTTSVKTPTGMYRLVRIIYFPDIPEEDLLAYLANFNVPQAAPEVIKTLDGPVAYGGESRRALRGFAPGITLSSHRTNANPLQDFQIQQLFGESDDTIRTALLTEKGTLAQAHGFIAGRAARARELHLSTVKLFEQGSPSPYIVSSEQRIIQMSYYFEELPIATYCQLVSCLTSSEDLVRVLNSESDRWTPVGQVSPDIQQTLEVARSRSRARLLDLLEILRYLRLAIPLQPSTSAQPLVTCTVNGQHPSAFDAVTADTWTPLSAPIYWQFTSEAPLYIWALSEDSPLFLKDMSVSTVEECSGFWRELQKLSIDDDYASSLAEIALPATTTNIGLARCLRRATSWTSGYNLSCNQSEYLRQFLNGANGYTPLEDEDGGEAHLDHLAWVISAPKDIVKQFFEKAHKKHVHELEKAQRRHRRAMNAKAKDTAAKAALASKAAEAKRQKEQDWDDMVNRIHPEPLKGPAATRVRRVRANFMQSSGTDHSKWEAEISEAIREASIAAKKVLPTSRPPIVSTVPRSGAVAPPVVVTDGPEKSIEDLLAQQGSLPVRQTSQKKKKGKDAVKGEPSADDTGRRTRFQWNRDFDELARDAFAVVRARCRNTGRLDLGAIVQVFPGVARNSVRQRIVHLKDSPGAEAYQARLEDKWYNLWVQHRGSETLPDKDPGSTTNFDLVAHIKFLRKHVDKNALRVGFVEQSSDVQIALPATVEQVETTWEVVDKRLPAPAWDFMWNVVAEEGREKQFAQQAFLTKMNEVPPVNDYPLEYTYVADSALKMMLGTPHESYDPEAAAKALHLVGEEYVKNATMNLLSRGILTKVVRDPKKSRPGRTLRISDNNQNALSGPLPQEVFQDASALEDLLAQEEDTGCWREWPLLVSDGDSAALLELVSEGKIDFQIDTTQARAARPKIDWNSKKADDDDIETAIQIRVNDNLSAAPRASPEFSVEPLVIQSNIQLETQPEAEHGKTAEGAEASCRLSSNGLVDCQACLDQAAKVLAEELSEENVEIMKQICMALKGAKTQGLTNEQLLANVESSSNASFLSVGRRMTEASIPLACWTGYKSIVLVSSDSLDPWTVSVSNSQDSRTKLFPRRWLDISGKKISDLWDAALRAIVAVILSRPGITQAEIRWRLRLVYDRQEVNEVLQYLLDDGVVTRRLLTSSPYQELGPPDDREEETISWFVRRTVSIFDGSDWLSTFAADSAMRTNFKSSRTSGLVLNKLRLFWDRITLSRFTAIYFTVALLHFAVQVVFQIQAFLINAQAATLLSDIVQKGNATQPGFLVAGQNQVRMCTSVPNTVDASSCMVMWAGNSSDSKAVSSTGGQHAASSASGTVGPTSPSIFLSSSASSSATTMPSRSSSAASSSISPIATRSAVSSTHASSSTKAVSSSTAAPSSSFGDLQEETRHSQSATSEPSSGYVSSSSSPRVVSTHTADVTVQATATSPEVSSGQVENADNRKRYTRRSVTIVAVEDNNQTEVVVDGVPDLGEVTLDYTCLVVLNWPIGILDETKREDLVFIMFQFWLLAMSLVALLNESVPHIIASLLTHILATGWAGFQIFNTAQFRSQFTDMTTNGACGVDLLPNYWRDRSNAEIPSLVLNAVVLVASAFLTWRLMKCFGWQTFKRVGASRTINRVYNAVLILSITIQLALFFIAVSGAVWIDQVYNGAIGRLTTDAPLFKGVTIVVEVLLIPWLTIGWISVRREASIPMFIFMVLSVMYLAGWASMFIAPTFRWTFVQWRFFSLIATASVLLTFVTVVLGIICRINFGKGLARYLNAQQPIEDTAEDIDEKVDLEKAEFPSNDLPLPTYSVAFGPGSQLLTTYGTPRQAPLVSDTASFNPPDTGFNYPGIDPNIPIIPRPEPVHPSLSRGDSRSSEQGGPSSKSDTQPNSKRWMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8E1</accession>
    <name>A0A401G8E1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar amino acid transporter 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0113100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609335.1">
        <property type="nucleotide sequence ID" value="XM_027753534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8E1"/>
    <dbReference type="STRING" id="139825.A0A401G8E1"/>
    <dbReference type="GeneID" id="38775339"/>
    <dbReference type="InParanoid" id="A0A401G8E1"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF696">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="187"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="594" mass="63148" checksum="B3FA7538B0207681" modified="2019-05-08" version="1">MSSLPTAATSISFRPQSATSSVVDVIASYRRAQAFLTDSVSASASAPSDEEDIDEEPQGDEEGGIGIETDRRSARDAYGFSNLEWDEDLSPIPERDGSPSSLSVISDQDRSTPIAAIPPAGESTPLLRKPTVRTSITHLNKAAKTGTIPAVANDGVPITLVRQTSRLSAQNKIIAENAHGKAVPGHSTFGQTLFNAIAILVGIGMLSEPLAFSYAGWIGGTMIIVSYGLVTCYTAKILAHIILDDLRLKSYSDIGHKAFGPRSGPLINALFCLELFAVGVALVTLFADSLYAVWPAYSPNTYKIFCLVFLIPTVFLPLSVLSYASMLGILSTLLIIVVILIDGFSKRDPPGSLWIPADTSLKFMGIGKLGVSFGLFMAGFSGHAVIPSLARDMVDPSRFDLMINYAFGIATAVYAIIGIAGYLMFGNSVSDEFSQDLAKYSVYPVLNKVALWGLVLTPISKYALSTRPLNITMEIVLGLETNTAPTSEHTAKSTTQGAEPLTAQRRKVVLKRILTAAERAAFTMLSVAVSILVPEFSSMMAFLGACTSFLLCVIGPISAKVALAGRCGFWDGLALVIGTVMAVWGTAATVWSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8P5</accession>
    <name>A0A401G8P5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0114080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609432.1">
        <property type="nucleotide sequence ID" value="XM_027753631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8P5"/>
    <dbReference type="FunCoup" id="A0A401G8P5">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8P5"/>
    <dbReference type="GeneID" id="38775436"/>
    <dbReference type="InParanoid" id="A0A401G8P5"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="437" mass="49084" checksum="A5CB3CAEEC141D32" modified="2019-05-08" version="1">MVPCYCTSKAAPRKISSQFKSNKNGEVKERKFDGDFNRRVINPMPINQLSHPLFKSDQRIEMRVPMFRPEALTEAAVGTVMQFPLSQDDTIKAYGVPTNVLMDFRVLSKPCSVIRDVTLSLIDTLDTANQKSSKDTRLVLTGSAGCGKSFLMLQAVEYCSASNWITLYVPRGITTVDSSSHYVYDPQTRTYLQPEYSYQLLRRFLSVNSRQLAELSTRKGFSVDDLSVPAESPLTDLIQVGLDDERLAPAILSRVLEEVSQQNTFPVLMAVDDIQAVYRTSLYRDPHYRPILSQYLSVPRLILEYACGSKFFTRGAFLGAVSTANTRFKMPIELSEALGLPLPRPAGPYYHRSSELEHYAGGLRNFPVPEQLNVGEAASLFEVWMADKALHSGEVRTLDNEQVYKPTDELFMSKFCEASGNPRSFVWNGLMATMNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8R2</accession>
    <name>A0A401G8R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0114440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609468.1">
        <property type="nucleotide sequence ID" value="XM_027753667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8R2"/>
    <dbReference type="STRING" id="139825.A0A401G8R2"/>
    <dbReference type="GeneID" id="38775472"/>
    <dbReference type="InParanoid" id="A0A401G8R2"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="604" mass="67268" checksum="B33E22741F751907" modified="2019-05-08" version="1">MVPPIVIPSPSVTVPVTPRSHLPSDSSSSSSDSSGYTPPAPISTMPFCPLATILQSSIKHPPSITSGKLTPSLLLQWEVACLEYFKRKSIADLDKVSHITGGMQDKLICDWVMTNASTLTTVSWDDFIKLMCSHWLEKDWEDKVLTVLIRMTHDNNNSLEDWIVTIEKQTLLRASPARNPSSNLSSATRTERMDNERRADKHRHMKEIERFLHSNCHISPATTRPSFSFKPTPKRISSSSSATTKSTCLGPLTNKECELLKKFFGCFKCRHLFVKCCTSDCMKGFPNATFYTTLTSDVRDVFKKCGHLFLDFNAKTLDNTVTVISTVPNNTDLDDNYVAAINAYSPLALTSDILGSGTDSEGNKCVLADFTVPHILWRGSLLSHFTAPLMISMLIDSGSLAALIRDSLATQLGLHHHTLAKPFPLGDAWDLEQQNLTNIPVIFGNPFLKCNHIIADVEAGILINKISNHDIMQPITPQSTPQSTSQFTPPDLRSLRECRHDATKAHDLAAHNQLVQHCDLMRDILLHTQPLLDSTVTISITSTVVAVPDGIEDLAYQETLSHENATMKNQFTDCFPDDIHHLDYLPTDVFHRFHLKDPNMVITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8U0</accession>
    <name>A0A401G8U0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 25 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0114420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609466.1">
        <property type="nucleotide sequence ID" value="XM_027753665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8U0"/>
    <dbReference type="STRING" id="139825.A0A401G8U0"/>
    <dbReference type="GeneID" id="38775470"/>
    <dbReference type="InParanoid" id="A0A401G8U0"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43572" checksum="CB9B66AE4A2A1328" modified="2019-05-08" version="1">MASSPLLRLISALAMLMVLSSSYWILGFHPSVVTHAALYLPSSNRDFMTGLDGDPSPRLAQNETLGVASSIYVVSLPRRTDRRATMERLRQALSLTWTYIDAVQPDDLGVINIMNHVRTFRERSQRRHDSPGSDLVDSGRFDWINDSDFDSLPLGAANNSPASSDDLLPLTCATTNLIDGPAFSSSIPAHMVLTTAKIACWYSHLEVIRRIAQSGFTQTSRLRPGLIGPTSLDGSLHGDDVSVILEDDVDMERDIRERLLAVWHLLPREWDIVFLGHCWSNESFHSPVADNSPAQNSTSLRGVSLHPSFAPRCTHAYALTTSGARRLLLHLRHPPFAYSRAFDQALSWLVSSGRLKAFSIVPSVVVQRKIVAGDIDPGARGTGSTWRDHLLNGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G985</accession>
    <name>A0A401G985_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0116120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609634.1">
        <property type="nucleotide sequence ID" value="XM_027753833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G985"/>
    <dbReference type="STRING" id="139825.A0A401G985"/>
    <dbReference type="GeneID" id="38775638"/>
    <dbReference type="InParanoid" id="A0A401G985"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="117"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="522" mass="58435" checksum="0348989EA2F94891" modified="2019-05-08" version="1">MKAGPLVLESIAKLRNQPRKLLKLKSPPSLRHINNCSHSLGSHAVTSNKAIPSPSPLVAPHSTLGVDILSAAVREDAPAVLEYPEEPVGLPAALLPPDIPAFMEVHIGDEIGPQGRYTIVRKLGYGSYSSVWLARDREYVRRGASRCVISAFISLAFERSAPSKYVAIKILTKQATRLVEKELMQEPRVLGFMRFRAQFKQGADKCVKLYDEFVCETARNDTGPHICLVTELLGMGLSRFCKQFPRRALPLPLLKLSMRHLLIGLNFIHYGCSLTHTDLKPDNIMLASPFSDEEITAILRDDPPKYYPTMSILDREVRPIVSQPLPTPPVPMDKLVFKLADFGHAQICEEEVTDDISPRAFRAPEIILQCGWNFKVDMWAVGCLVRHDPQQPTLFFTECLLQTFELLTGSQLFTPEDNPAEGITADDDHLLRIMQIQGRPFPAEFLADSFNRDQFFNADGTLIHMPTKIDPRTIAERIRDSETVEGPQELAAAAAFIERCLQCVPEDRPDAEVLIKDPWLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G994</accession>
    <name>A0A401G994_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0116480</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609669.1">
        <property type="nucleotide sequence ID" value="XM_027753868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G994"/>
    <dbReference type="STRING" id="139825.A0A401G994"/>
    <dbReference type="GeneID" id="38775673"/>
    <dbReference type="InParanoid" id="A0A401G994"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="3"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE78756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="147" mass="16195" checksum="C304A559C5CA54DD" modified="2019-05-08" version="1">MKSSDVLGLKTALANARKSYDEGGVPIGAALGHNQRIQKSSAILHGETAALKNAGRLKAEVYRQSTMYTTLSPCSMCSGAILLYKIPRLVIGENANFVGDEDLLRSRGVEVVVVEDEECKELMSKFINEKPEEWFEDIGEIPEEHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9I6</accession>
    <name>A0A401G9I6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0200430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609759.1">
        <property type="nucleotide sequence ID" value="XM_027753958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9I6"/>
    <dbReference type="STRING" id="139825.A0A401G9I6"/>
    <dbReference type="GeneID" id="38775763"/>
    <dbReference type="InParanoid" id="A0A401G9I6"/>
    <dbReference type="OrthoDB" id="2798875at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE78846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="322" mass="35443" checksum="0EA074B16BBEF841" modified="2019-05-08" version="1">MADTTDSRPLVLVFGGTGHTAVVIINGLVKSGAFRVATAVRASSLSKPVVVEYRKNNVIIHEADIDDGVEKLAKVLHGVDVLISTITARKILSQRDLFAAAKQVGVKRVIPCDFGTPGARGVRDLLDEKLEIHDYIKSLGLGYTFIDIGWWMQISLPCRSTSKSMMRDASRQLYNGGVKKILVTNLDNVGVYVAHVIADERTLNHSVLIWEDQVTALQAMEIGAKVSGEGSALIENVAHVSANELLERIAAAKEEYAKTHSFVSFATKTGYQYQYSIHVLGENSLENAKALGYLDSRELYPDIIPDTLENYAPKFYENEYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA69</accession>
    <name>A0A401GA69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0202480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609964.1">
        <property type="nucleotide sequence ID" value="XM_027754163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA69"/>
    <dbReference type="GeneID" id="38775968"/>
    <dbReference type="InParanoid" id="A0A401GA69"/>
    <dbReference type="OrthoDB" id="2792963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="244" mass="26759" checksum="573C1395DB365EA0" modified="2019-05-08" version="1">MGVQMVARPLAASSGVVVRACQVPSSTYVGSPNIGCVASYFSTNSALRAPSRKKPDLEGVPIIENPPPDVVLLLLEGRAATCAGELSQRVIFGRNPTPELYYRGIVTNIRLMSHYMNTVDRDEFRSSTVEDGSPIARGRKAYITFARVADRWMNEAFSILPPGPVDPELADTLYYFRMNSQLIDLYEQGDKIPPPRPAWTDICDAIVLASHVAHDPLDGAAGGVPWNEALYDVTVTPREPDERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAG1</accession>
    <name>A0A401GAG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0203340</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610050.1">
        <property type="nucleotide sequence ID" value="XM_027754249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAG1"/>
    <dbReference type="STRING" id="139825.A0A401GAG1"/>
    <dbReference type="GeneID" id="38776054"/>
    <dbReference type="InParanoid" id="A0A401GAG1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019199366" description="laccase" evidence="12">
        <location>
            <begin position="26"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="168"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="362"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE79137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="516" mass="55940" checksum="14C056EA979B4069" modified="2019-05-08" version="1">MSLGILTVYLASIFMAISFAASALGRIGPKADLPIVNAVVAPDGISREAVLAGSTFPGPTITGNKGDKFLINVMNRLTNETMLKTTSVHWHGIHQHSTSYADGTAFVTQCPIASGASFLYNFTVPDQAGTFWYHSHLATQYCDGLRGAFIVYDLNDPHRHLYDVDNDSTIITLADWYNEAAAFQPLKPIPDAALINGLMPNNSSNTPAAVIVVTHGLRYRFRLISMSCSPNFVFSIDGHNMTVIEADGENTEPLNVDSIQIYAAQRHSFVLDDNRPIGNYWIRSVASAGRNGSAILRYIGAPDVNPNTVSEPSLNPLVESNLHALTNPRAPGAPTIDGADVVINLNFTANATNYFVNGVAFVPPMVPVLLQILSGSYSAQKLLPPGSVYALPRNKTVQITMPGGVTGGDHPLHLHGHSFSVIRSADSDSINYVNPVRRDTVRIGEQGDNVTIRFDTNNPGPWFLHCDIDWHLKLGFAVVMAEDTGDTPNIDAPPRKHPPAWSRLCPIYDALPTSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAI6</accession>
    <name>A0A401GAI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0203660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610082.1">
        <property type="nucleotide sequence ID" value="XM_027754281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAI6"/>
    <dbReference type="GeneID" id="38776086"/>
    <dbReference type="InParanoid" id="A0A401GAI6"/>
    <dbReference type="OrthoDB" id="2260578at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="309" mass="33722" checksum="1DA0C5E3FAACF5A0" modified="2019-05-08" version="1">MDHSETNMGRPSGVGPVRSNTSTSSRSSTPLNRSIDQSLLQPVVRSRRTPIACTECRRRQVKCSGGTPRCERCEKRDMQCEYIPLHQQKATSSANVVAPIPQSRATWPGVANMSVPSNRSVQPSPAQLHNYQGFVPTASPGQRVDLQNPFVMPSQTPSVRRGYSQSTTHSAPAYGNMGFDQSYLSNIPATPEASLAMHPTYAQSSVVPAQYDYPGVPSYNLYGQAGTSGEMVANNPTYDYRLSDQQRGLSGQMAVPASQSESYQERYYQGSPELYDTSAGNVAPGHPTSSDWRHSADPTYPGYQDPSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAR1</accession>
    <name>A0A401GAR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">54S ribosomal protein subunit img1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0204580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610173.1">
        <property type="nucleotide sequence ID" value="XM_027754372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAR1"/>
    <dbReference type="FunCoup" id="A0A401GAR1">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAR1"/>
    <dbReference type="GeneID" id="38776177"/>
    <dbReference type="InParanoid" id="A0A401GAR1"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19174" checksum="B3563D0B7CA556C4" modified="2019-05-08" version="1">MLLKAVRRCARSLSTATAPYPFSSVAKFPTPPATPPPEPLRLGKGLMPYLQQTLPEPAKQKLFTTYFSKRHPLRILPGSVLTVSLAHAPTTFSGVLMQVRRRGLDTSFVLRNVINRTGVEMQFFVSSPHLKDIKIVQRAGGGGGKAGRRMRRAKLFYLRDSPEKMTAISAGVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAS2</accession>
    <name>A0A401GAS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610181.1">
        <property type="nucleotide sequence ID" value="XM_027754380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAS2"/>
    <dbReference type="FunCoup" id="A0A401GAS2">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAS2"/>
    <dbReference type="GeneID" id="38776185"/>
    <dbReference type="InParanoid" id="A0A401GAS2"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="436" mass="48118" checksum="5DFD8D8FF7CE1405" modified="2019-05-08" version="1">MVNYGGDEISALVVDIGSSSVRAGYAGDDTPKAFVPTTYGFIEEPSSPEDDIEMADVYGVEKLPPQKKLNLFIGQNGPSIWREGMQAGNPVQNGLIHDFNPIPPLISHALVDMMRCNPEEHPVLVTEPAWNTKENRERMAEIMFEEFHVPAFYIANTSVLNAFAAGKGSALVIDVGQSTASVTPVVDGFVLRKGLMYSALPQLVHAHAKHLLVTPSSRRAGIQLIPHQLIASKQPVDAGVPPRFELRQDRIAGTTESWRTWAESREVDEWIQSVAGILDQGWNEQAATQRGPRHYEFPTGYNYHFSSLERSMVGEQLFSHSPQMIATNPNLPKTIPALISASLSACDVDLRQVLMGNVVLTGGGSLFSGFADRLHNELTRNFPHVKIHAPGNPTERRYGAWLGGSILASLGTFHQLWISREEWQEHGKSIVEQRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAX5</accession>
    <name>A0A401GAX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0205100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610225.1">
        <property type="nucleotide sequence ID" value="XM_027754424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAX5"/>
    <dbReference type="STRING" id="139825.A0A401GAX5"/>
    <dbReference type="GeneID" id="38776229"/>
    <dbReference type="InParanoid" id="A0A401GAX5"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="224" mass="24539" checksum="59184A46FD3B202F" modified="2019-05-08" version="1">MALLPGNPIQQRVRDLISEHREAGWDKAWQENVTPWDAGQPQPALRQLVESKILDLPTSGRALIPGCGRGYDAMLIATNLGLDTLAVDISPTAVAAAKAAVEGSNLPSSVKVTIELDDFFALASSAPKQFDLVYDYTFFVAILPSQRDDWGRTMSSIVKPGGYLITLVFPIDPPQEVGPPFYVRPEHYVGPLGAGWEKVYDEAPEVSLGSHAGRERMIVWKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAY2</accession>
    <name>A0A401GAY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0205260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610241.1">
        <property type="nucleotide sequence ID" value="XM_027754440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAY2"/>
    <dbReference type="STRING" id="139825.A0A401GAY2"/>
    <dbReference type="GeneID" id="38776245"/>
    <dbReference type="InParanoid" id="A0A401GAY2"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE79328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="545" mass="59487" checksum="06BE9C010883218B" modified="2019-05-08" version="1">MNPALRHSSDSRSERSNKEVSQAYTVEWDEEVRAAEPRLRGRPLTYALAFVAGTGFTLFGYDQGVMSALLSANQFDKVFPQTVTSPTLQSFLVAIYEIGCLFGALSNLWVGDFLGRRKTIVLGGIIMIIGAILQTTSFSYAQMIVARIVTGLGNGLNTSTVPSYHAECSPAASRGSFIMVEGSLITFGIMISYWIDFAFFWITGSSAQWRVPIALQIVLAVMMVGGIAFLPESPRWLAKHGRNAEALAVIAALEDKPHSSESVQQTYKGILEAIAVETGVGSPKASLREVFTGGRTQNFRRTFLGVVNQCFQQITGINLITYYATLLFQRLGLSAVNARIIAAANGTEYFLASLIAIFIIDRVGRRKLMLFGAVGQTLTMVVLAVLGSVDSSGAQIASAVLLFVFNSFFAIGWLGMTWLYPAEIVGLRIRAPANAFSTASNWIFNFMVVMVTGPSFSNIHWGTYIVFAALNAFIIPVVYFFFPETAGRSLEDMDVVFALAYNEGVSPVAVSLRKDIPLAGTPEADEILGVRPRDKDEKETREHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB07</accession>
    <name>A0A401GB07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0205210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610236.1">
        <property type="nucleotide sequence ID" value="XM_027754435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB07"/>
    <dbReference type="FunCoup" id="A0A401GB07">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB07"/>
    <dbReference type="GeneID" id="38776240"/>
    <dbReference type="InParanoid" id="A0A401GB07"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019543322" description="alpha-1,2-Mannosidase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="9">
        <location>
            <begin position="732"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE79323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="864" mass="96575" checksum="3AF190656BF43E1C" modified="2019-05-08" version="1">MRWPTYWPRVVLLLLIIGLEGHRWSYNHAAGLAEGAEWTTARKLDARERTRNLWYHGFDNYMRYAFPLDELAPLSCRGRGPDWHNPGNIASNDVAGNFSVTLVDTLDTFVVLNDRPGFEAAVRNVIDYVSFDIDTKPQVFETTIRVLGGLLSGHLFARQTGQPFYLPWYHDELLSMARDLGERLLPAFATPTGIPYARLNLRHGIPRGESVETCTAGAGSLILEFGTLSRLTGDPRFEKAAYKAFFALWNRKSDIGLVGNTIHLWTGSWIQPEISSIGAGIDSFYEYALKWYILSGEVEFLDVWQESYAAVMRYARAPDGFSYRSVNIHTGDMAYSTFDSLSSFWPGLQVLAGDIENAIKSHLTYWNVWKTLSGLPEVWDMSFRQATSFQYPLRPEFVESTWYLYRATRDSFYLDVGERILYDITTRAKVLCGLTGIQDLRTNARDDRMESFVLSETLKYLYLLFDEANPIHSDDSNYVLTTEGHILRLSQDMLKPMSSARRKLRGVEHPQCPAYQPPLLAYDDWNAESGIIGGIRSRADMDYARQLIGTRPSDSEIKAWSPGGWCARPKYSLYSFDFILSPKGEVVPEDEHPSVKKVMTVTDGYLLQNVTGIRAHIVSRLDGKGYDVTKLGPYAVKTGQLVYVNDPELILTPVDDKASQGHPRVPEVELRFFVDHLDPLFHLQPHGAPTEIFVTASTALFGGDPTIQPPPSEAAPPFGRGAGVPIIRDPANPLGCQPYSRRFSDHAVVVQRGDCTFLEKLVLAKAAGASGVVVLNDEDSNINPSTGQSELELVGDAVDDAVIVVLRQSVAKVVTDLMDAADGYGQLMMAVEPEGQFVTESTSRDPNRVLYLNGHPLLNTRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB41</accession>
    <name>A0A401GB41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610266.1">
        <property type="nucleotide sequence ID" value="XM_027754465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB41"/>
    <dbReference type="GeneID" id="38776270"/>
    <dbReference type="InParanoid" id="A0A401GB41"/>
    <dbReference type="OrthoDB" id="2964597at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="33268" checksum="25566A264D0AB7BD" modified="2019-05-08" version="1">MLTPEETNEDIALVDDREIRTHSGSNFLTTLRYNLKKSALGSLFVSYHASLRSDLQDTFGSGVGAHTGIEARTATRKTAQLDDDSAQDLGRHSPYFVSDIAELSTPTLPSRRQSRRISVPDVKAVISSITGSLGRSRSQSNASSVKSVSSSARGTSRPRLFSITASGSTVTDSTPPLTPSSVFSAACPPCADKPGFPRTYESTPGAEEDEVLSRESLLTSVKEGKKPERSICYDELIADISNDYMQSSPQQQQSDSFDEDSEEWFGLEYTLEISKRDQGAIARASVSAGEYSKARNHIRACTCSPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB70</accession>
    <name>A0A401GB70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0205950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610310.1">
        <property type="nucleotide sequence ID" value="XM_027754509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB70"/>
    <dbReference type="STRING" id="139825.A0A401GB70"/>
    <dbReference type="GeneID" id="38776314"/>
    <dbReference type="InParanoid" id="A0A401GB70"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="86" mass="9647" checksum="EA3EE02A5B06AA41" modified="2019-05-08" version="1">MRLRPDCSQLLPPPPPSSVAMASLANVFYNSLVKRNSVYVTSIFAGAFAFGVGFDVAITSFWDNWNKGKQWKDIREKYIQNDSTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB81</accession>
    <name>A0A401GB81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">SCP_0206050</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610320.1">
        <property type="nucleotide sequence ID" value="XM_027754519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB81"/>
    <dbReference type="FunCoup" id="A0A401GB81">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB81"/>
    <dbReference type="GeneID" id="38776324"/>
    <dbReference type="InParanoid" id="A0A401GB81"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="202"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="GBE79407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="676" mass="73293" checksum="0E83B13E6648BF64" modified="2019-05-08" version="1">MDKLSSLAKFKASCPYLGRTKTSTLRTLCTSASPRYPSLSKLTEKAAKCPIMGPALQLRSSQMVAGYASVAGKTEVDEIHHHQGVFPVPTGDNIQKCPHASKAIAAARMAEDLTKLKEKSAAKAAQGSSTSKAATAGCPFHAAQEGKDKKSAPTDRYNYEKFYMDELEKKHKDASYRYFNNINRLATKFPIAHTGDPKDEVEVWCANDYLGMGNNPVVLETMHRTLNTYGHGAGGTRNIAGNTGMHLALEQELANLHRKPAALVFSSCYVANDATLATLGSKLPGCVYFSDSMNHASMIQGMRHSSAKRVIFKHNDMEDLESKLAQYPKETPKIIAFESVYSMCGTIGPIAQICDLAEQYGALTFLDEVHAVGLYGPRGAGVAEHLDWNLHKRAAQSSEPIKGTVMDRVDIITGTLGKAYGAIGGYIAGSTDFVDMIRSYAAGFIFTTSLPPVNVAGARASISYQKEYLGDRQLQQINVREMKARFEAIDIPVVPGPSHILPVLVGDPALAKLASDTLLSRHNIYVQSINYPTVARGDERLRFTVTPGHNLDQIIHVVKAVDQTFTELGCKRTSDWRAEGGRANVGMPNAQPVHPIWEETHLGLLDGTAPRVLRAGDKGVVDTRAVRVTREKFNDLLGPYVEPGVNRASVMENLAVPGLTLPVESLHAPIPVAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBI3</accession>
    <name>A0A401GBI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0207070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610420.1">
        <property type="nucleotide sequence ID" value="XM_027754619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBI3"/>
    <dbReference type="STRING" id="139825.A0A401GBI3"/>
    <dbReference type="GeneID" id="38776424"/>
    <dbReference type="InParanoid" id="A0A401GBI3"/>
    <dbReference type="OrthoDB" id="2746120at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="724" mass="76766" checksum="AF90E03F6C58451D" modified="2019-05-08" version="1">MPKDIVTAFEKSIADDHAKGVENWKHLCEKPLADGPEQAEHYHHELTSAMYWLKPLADYLSDKFGMAVSILLAGPIADLNGAIEVHSAHVGQTPGLVNLCWPEFDPIGYTDAEASMVRFAKHLYCTAGVAMADGSPAPQVETSAQARAEPGPSGQASSSSCVGSSSPVRVSSTVSAVVNPSRAIVATSSASVSLPVPFAQAESVDVSSNATASSSTPSQPTLTSIPTLVREDGHMHETVHAGGLFILPPVVNRVMVPPTDFQLLTVGRSDDVFSSPATSSPSAAVVPPQPVASDALPSLSAPTSITTAETSTSSQPVTGSTCPSVIDLTSASVTETSMQPFLPSATPLSSQSALPSSNSRSDINLSSSPIAPSPIAPAIPSSTSTVRDSDLVATIPVLNLTCFSDREKKLYENFIRERGWGSEWSRMLTSLVLLEKEAPATVKRLGGNKARPAEVASWIKIAQPARDMEIDDPIAFARGWWGWWTSLQPSTRAVGDDGKPQQDWSAVVWDSLCITGPNGLLLVVVCLAWWGMVVVGKASADQENNWCAAVADVAWTLDQILSSLSGSSSSNPDGSTTSRESLSLCGTMSTLSAWKGSSVLLKRRVLDLLTTEHTDRQRATSQEKRNVLAHCVKQWCTIQDLYMPVVSQLRSPMSSGPIPAPSIGDAPTDGDTLCLTSTANLTLWLLSALPDALRNSLHMQDLLAKEKLLHLAQADDALAEIHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBQ7</accession>
    <name>A0A401GBQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0207630</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610476.1">
        <property type="nucleotide sequence ID" value="XM_027754675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBQ7"/>
    <dbReference type="FunCoup" id="A0A401GBQ7">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBQ7"/>
    <dbReference type="GeneID" id="38776480"/>
    <dbReference type="InParanoid" id="A0A401GBQ7"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="36"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="411"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="641"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE79563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="694" mass="76707" checksum="7B1EB876803E8706" modified="2019-05-08" version="1">MRRQLTKSPPPSPTKERRVKSPEPYPVPSNNPASQYTLLEKLGTGSFGTVYKAMHNDTKQIVAIKQIDLEDSDDDISEIQQEIANLAQCDSEYVTRYYGSFVVAYKLWIVMEYLAGGSCLDLLKPGVFSEAHIAVICRELLLGLDYLHSEGTIHRDIKAANVLLSSSGKVKLADFGVAAQLTSTLRHTFVGTPFWMAPEVIRQAGYDAKADIWSLGITAIEMAKGEPPLAEYHPMRVLFLIPKAKPPTLEGPFSASFKDFVSQCLTKDPLARPTTKELLQHKFIRNARKTSYLTELIERYQDYRARSPGRGPQMYQASVRNSGVWDGTLRSDWSFDTIRTSSAMGSLRSMAKDIMPPGMIPDEDYEDDRSVYTEDELHVSIRTSAATRGSDVAMSSAALGMNMAAQHSTVIIRPRSPPVDVKNMPSLMADSSSEETLGIEPSTPQDEPQSPESVEPPPAYTGSVRSTRRSSFQARHNLGTGTVLGEADLGSGVDTIRPVKKVDTVRSLRMSSEFVGSTRSREGSSSAPPSPQSQKGSHKRVPSEAAKAGKTLIDEVLLPLFNKATRDDMDAREIESLSMISRGFEELRDVNPQLAYNIVLDLLSGINENTAVRQHIQTARGLFPHKRVVRRSEMTSRGLVVTEEEEISGMPPSSSPPSTEERAEAGLPTRKSPIGELLYMRWLEGLRLKWPSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC76</accession>
    <name>A0A401GC76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0209580</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610670.1">
        <property type="nucleotide sequence ID" value="XM_027754869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC76"/>
    <dbReference type="STRING" id="139825.A0A401GC76"/>
    <dbReference type="GeneID" id="38776674"/>
    <dbReference type="InParanoid" id="A0A401GC76"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019089787" description="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1" evidence="14">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE79757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="85" mass="9657" checksum="AE146E46A1B3AE08" modified="2019-05-08" version="1">MPIPWEALIPFGLLTSMFVVAGSALNVSKHAQNQGKPIRYHIDAWDEMMMDRDKRLTGHLRGQASEPKAPEGFATNSEWYTERVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCD9</accession>
    <name>A0A401GCD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable nucleolar complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0210160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610728.1">
        <property type="nucleotide sequence ID" value="XM_027754927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCD9"/>
    <dbReference type="FunCoup" id="A0A401GCD9">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCD9"/>
    <dbReference type="GeneID" id="38776732"/>
    <dbReference type="InParanoid" id="A0A401GCD9"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="841"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="887" mass="100792" checksum="4E41886EA8468AF5" modified="2019-05-08" version="1">MAKGSQLSQLKAALNQAGLSRQPQSGKKRKRAVPEERDKEKKAAKLQEIHQKLNPFDVKVTKLKHDVGGRKIIGTSGRPAQSKQAGIEQRKKTLLKEYEEKDHAGGIVDRRFGETDSTMAPEERMLERFTRERQRASKGAVFNLEDEDELTHYGQSLSRLDDFDNVGLGLDEEDEEESGQIDRQTVQKSHFGGFGDDDGDDEGEGEEPARKKTKAEVMAEVIAKSKDHKFQRQAQQEQDENIRHNLDQEFDTIRSLLYAPVASTSGSVKPAEEPDMQYDQLVRELAFDQRAKPKDRTKTEEELALEEKEALEKAERRRIRRMNGEDEESEDEHEARAKRKQKARGGDDLEDDFREEEWSGLGTGLGEEDAIEEDDDDEEVEGEKESQEEDDNDSPGEDEDEVGSLSDSDDSGVAGEDAEVLVKCTQRSRTKSKVPGQELPFTFPCPTTHDEFLDVIEDIEDKDVPTVLQRIRALHHPSLAEDNKFKLQALTSVLIDHILYISSPPVPRFTLLSSLMPHLLALTKAYPIQSAEHFVEKLTLMHKNLRRGLSRGATNPDAKTWPGLPELSFLRVIGQIWPTSDKNHHVVSPARLLMGAYLGLSRIRTLQDLASGLFLCTLFLQYESLSKRFVPEAINMLANSVLHLAPHKFVDKSEVPGYFPCPDFRSEHCPSLTVTPVKIKNLIVNKPDLSSILNDRNVGEQAKVDLLGLSLELLGRFADMYKSSPGFIELYDPIVELVGGIVTKGLPMDLISRVTTLQNTLGRLLNFSRQARRPLMLQSHKPIPIPTYVPKFEHSSSNYLRNRDPDHERNETAKLRNQYKQEKKGAIRELRKDARFLAAVQQKRQKEKDRAYNERMKRVYGSIESERAEQKAMEREKTREKRRSARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCF7</accession>
    <name>A0A401GCF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein ORM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0210610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610772.1">
        <property type="nucleotide sequence ID" value="XM_027754971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCF7"/>
    <dbReference type="FunCoup" id="A0A401GCF7">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCF7"/>
    <dbReference type="GeneID" id="38776776"/>
    <dbReference type="InParanoid" id="A0A401GCF7"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE79859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26307" checksum="09B19CC7A186B103" modified="2019-05-08" version="1">MTNVLTSPTLSVPTLDAASGLTARMTRSRSSSLVKVETVGENSQEEALDQNLYENVNADWVNSKGAWLMHPVLIFAGKIVVDTIPGMQQEISWFVVNIGYLSLSYLMFHWVTGIPFQSDLHGGVYDDLTLWEQIDYGAQYTPAKKWLFCVPVLLFLASTHYTHYNPWFFAINLTGLILVLIPKLPQLHRHRLRFMVKDMASGAVTPATVAGDEPSTPTSGELNTIPPIRISEVEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCK2</accession>
    <name>A0A401GCK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0210730</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610784.1">
        <property type="nucleotide sequence ID" value="XM_027754983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCK2"/>
    <dbReference type="STRING" id="139825.A0A401GCK2"/>
    <dbReference type="GeneID" id="38776788"/>
    <dbReference type="InParanoid" id="A0A401GCK2"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019344689" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="222"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="580"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE79871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="610" mass="65950" checksum="EB75CBA1DD1A106B" modified="2019-05-08" version="1">MRSLSAWLLLALCPFAYAAPRGCTHKVKESVPPPRGWTKLELAPANHNIELRIGLPQSNFAELERHLYEVSDPFHERYGEHLSKEEVEALIAPNPESINRVDEWLASHGITAEDFSRSPARDWVKVKVSVSLAEKMLDTKYHVWVHDESGDAVVRTTSYSLPEDLHEHVELVQPTTMFSRFNSLKTTYILDQDLPAATNPDEPTISVPTAYNGSVDASCNGTITVTCLKQLYNAVGYTPSASNGNHIAVTGYLDQYANLEDLQMFYADEVPAAVNTSFTYVSINGGQNNQTLDEAGAEADLDTQFAFGLTFPTPGTFYSTGGSPPYVPDILTPNDTNEPYIDWLGYILNATNPPQTISTSYGDDEQTVPYSYARRVCAEFAQLGARGVSLTFSSGDGGVGDGNPDPATQQCYTNDGRNVTEFLPAFPASCPYVTAVGGTIYVPEQAVFFSGGGVSNYFPRPSWQEDVVANYFDNLAPGTYSGLYNTTGRAYPDVAAQAFYFKIYLSGNATLIGGTSAASPTFAGFVSLLNDARISLGLSPLGYLNPLIYAVGSRVPEAFNDITVGNNPGCGTEGFNATAGWDPVTGFGTPNFANLKALATYNTTAISKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD65</accession>
    <name>A0A401GD65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">SCP_0212880</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 30">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610998.1">
        <property type="nucleotide sequence ID" value="XM_027755197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD65"/>
    <dbReference type="STRING" id="139825.A0A401GD65"/>
    <dbReference type="GeneID" id="38777002"/>
    <dbReference type="InParanoid" id="A0A401GD65"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="23" id="KW-0862">Zinc</keyword>
    <keyword evidence="23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="25">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="26">
        <location>
            <begin position="483"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="222"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="714"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="GBE80085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="29">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1199" mass="133928" checksum="0079B97539159FE4" modified="2019-05-08" version="1">MAILREHGVLKYVDGTSEKPKPANATTPTAGETAVITKWVEGDQKAQTVIELLLSDSQMIHIADATTAAEMWNQLKLVKEASGQLGIMAYQRKFYRTVATEGSDIAAHITELRRTQEQLHMMGSKVSDDEFRAILITSLPESWDQFTSAYLGATSQKDKLPTSHELIAILLEEYRRRREKGSADESALAARGRWTQPKNTAQGGTDRKSDAECWNCHKRGHTQHECWSKGGGKAGQGPQSKKGGRVQVHTNQAQSTNDVLRDVAFRTDEAIGIGQQFSSQFSCYDWLADSGTTSHVTNLRDAITDFMPLEASSITSIGDQSIRALGRGTVKVNSRIGGKTFTFCLKDVLYAPKATNNLVSLTRLDEAGGHFDGGDGGITLRESGGHAITEGRKIGRLYLLNMRVKAAMPSEEHANIARDDSDSWESWHRRYGHLGFTGLEKLYKENLVEGLTVDENSMPLTQCEACVQAKQARRAYPKEVEDRSQMPGELTHSDVWGPTRVVSIAGSRYYISFTDDCTRRCQVLFMKHKSEAFEKLKEYLTFIGRHFGHLLKIVRVDNGSEYINKNLKGWCRAKGIELQTTAPYSPSQNGVAERFNRTLLELARAMLIARKLPNFLWAEAVAYAAYLRNRAPTKALHGKTPEEAWTGKKPNVAHLREFGSDVWILTEGQNLSKLEPKSKKHTFVGFADGQKAMRYYDVGVRSIRVSRNFVFADAPNPASNVPVHQLDDSDRLPLKGESGGAVKQQPPTSASKPASVPVKADQSNKKHDGNHITEEDLPPEMQESMRERPTFLSAPPKIPLRRTTRVMQDHDYRKMDNPRAQPAKLREPPGVLKENAPGESAKVAVMPEELEEIAQALYATALASGDRTASAGDEPRSLAEAQASPEWSEWEKAVKAEYDQLQGMGTWELQDLPKGRNAVGCKWVFQRKTNKEGQVVKYKARLVAQGYSQIPGMDFLETFAPVVRLESIRAILALAVVNNWEIGQMDVKGAYLNGDLQEEIYMRQPEGFDDGSGRVCRLHKTLYGLKQSGREWNRKLHRELTELGYKRLEADPCVYLRERKEGEVQIITVWVDDLLLFTNSPKLMEELKRDLQDLFEVTDLGEPQKIVGIEIERDREVGTLQISQQHYIESILKRYQLENANAVGMPLDPNVAFTAEDENEEADDHLAGGYASMVGSLIVPTTCPLDSGKTRSTVPRRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDZ2</accession>
    <name>A0A401GDZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611317.1">
        <property type="nucleotide sequence ID" value="XM_027755516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDZ2"/>
    <dbReference type="GeneID" id="38777321"/>
    <dbReference type="InParanoid" id="A0A401GDZ2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="10755" checksum="6050B90183575825" modified="2019-05-08" version="1">MLLRDLHAIQFVEEGEENALPPFMVNSLLSFDLAEDLLERCILITTDVENGNLTRPSIPRLPSARLNKAGKHIEALAAHDEDHQEGGSGPASLAEPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEA2</accession>
    <name>A0A401GEA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0302210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611419.1">
        <property type="nucleotide sequence ID" value="XM_027755618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEA2"/>
    <dbReference type="STRING" id="139825.A0A401GEA2"/>
    <dbReference type="GeneID" id="38777423"/>
    <dbReference type="InParanoid" id="A0A401GEA2"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14725">
        <property type="entry name" value="ZIP_Gal4-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="602" mass="67113" checksum="6D29FDC995D782D2" modified="2019-05-08" version="1">MAEKQITNSSPGPSSSTLQRGKACLRCRKRKMRCDGAKPACQQCVRAKKADGCEYDDGKGKTRTQLMREHIARLESRIKELETNETSTPSVTLFDPHAPSPYYSESSGSSSHGSPGNISLSASTSPVPYGPDEIRSTMVSPLTVKYPDMDSSWEAQWDQMTNFASGSQVSDAYRASEEPPVELAQMLLELFLPHRHQCGLEVHIGRMRESLGLPPSEQRHPALMNTIYLWACYLSRPESLCEHEPVYLSRALSAMNEAIQYPTKVVDIIQASCLLSMYYLSNGRLFEGNYYASAAASLALQYRLHQIDSDELSAHPGIGLWEPTFSLEPEKDPIERGERILTFWQVYSLDRCWSVALRRPPIIPDNDHPSTRITTPWPQRMEEYESGDLEGSSGNGTIFDFLAHQAQTSSLVGGFSTIALRAKASVLFEAADRLSSSFMRLPASNTMMDEFRVLEHTITRFTATLLPLHQLSAAVPEEKFTLIVVHSLAHAAMIHLHAPFVERDPISREKCARAARAMMLVTKHIAELDFDFLEPIVGPCWLSGAKVLESELIRLQASWPPPNMMEIRGELGGFLFVLTKLSARFPLLGYEAAKVQSSLEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GED7</accession>
    <name>A0A401GED7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0302690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611467.1">
        <property type="nucleotide sequence ID" value="XM_027755666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GED7"/>
    <dbReference type="GeneID" id="38777471"/>
    <dbReference type="InParanoid" id="A0A401GED7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="208" mass="23170" checksum="D16BC8EAFD0193A0" modified="2019-05-08" version="1">MAELLGEISTDAANLTIMTTGTSKVCNWLSRHTTESSIVQTRKNLHEGMEILYEAAPHIPRQTMKDLIEEHDILLAQVDQIELDSQAPLNVRKRWTNILRPLHNNSGAHTAAKMSTRLVYKIRRSSDIAKSMRLSEGGARSQIETFSSNWSIIDSQSTMTFANSEHGLNSASHSCKEASSDGMAPIDEDTDILYDNPWNEDDVDAQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEG3</accession>
    <name>A0A401GEG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0302080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611406.1">
        <property type="nucleotide sequence ID" value="XM_027755605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEG3"/>
    <dbReference type="FunCoup" id="A0A401GEG3">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEG3"/>
    <dbReference type="GeneID" id="38777410"/>
    <dbReference type="InParanoid" id="A0A401GEG3"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="576"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="693"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE80493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="786" mass="87616" checksum="F2292B801002A9C6" modified="2019-05-08" version="1">MSRESTAEQHGIPDEGEEEFELIRNYEDFTTIDWIQDSIIERNRRLRNAQKVHAARRGPRGELTVAWVWSHLWKILNSAQSWIVVSLVGMCIGVNAAIISIITAWLSDLKLGYCSDGWWLNRQFCCWEIEGGDDACDSWHAWSTAAPGRWAIYVLFAASFSFVAAHLVRSLAKYAAGSGISEIKCILAGFIMKGYLGFWTFVLKSMTLPLVIASGLSVGKEGPSVHVACCIGNLVASLFKRYSRSQGKMREILTASSAAGVAVAFGSPIGGVLFSIEEMSNTFSIKTMWRSFFCALMATVTLSAMNPFRSGKLVLFQVTYDRDWHFFEIIFFIILGIFGGLYGAFVVKFNLQFAAFRRKHLANYPVAEAVTLATITAMVGWVNRFTRIDMTESMSILFRECQGHGDYDNICQTSVQWPMVNSLFLATILRIGLVVVSYGCKVPAGIFVPSMAIGATFGRMVGIIVKAMYRAYPESSMFAVCQLDTQCITPGTYAFLGAAAALSGIMRLTVTVVVIMFELTGALTYILPTMIVLLVTKAVGDFLGTNGIADEMIRFNGFPFLEKDDQAYNVPVSRVMRRELHTLPASGICVRDIEERLASTNVKGFPITSPDARHSLVGYIERSELLYVLDKARKVRNISPETPCSFASNEEDQRRVEYPGIATGPAVGIDEDISMEIIETSATPDVLKFWPWVNQTPLTVSPQLPLEIVMQLFKRMGPRVILVEDHGALAGLVTLKDVLRFTLTEQSEVESPWNQRQFEGIVEEVWTWTSYQFDKAISWCRRLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEJ2</accession>
    <name>A0A401GEJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0303170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611515.1">
        <property type="nucleotide sequence ID" value="XM_027755714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEJ2"/>
    <dbReference type="STRING" id="139825.A0A401GEJ2"/>
    <dbReference type="GeneID" id="38777519"/>
    <dbReference type="InParanoid" id="A0A401GEJ2"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26126" checksum="9E6C111F7EFD9109" modified="2019-05-08" version="1">MGKKNKDQPPNVSLGSVTSRDIIQRINFLYQASAYLTSISSVDNIAVSAAPNLSATEHRRLQRKSKNGKLLLHRGSKTDERQKGAKARHPASTAELSRSYIRSMRVIGQKTTVKLDPNIKRTLCRGCNVVLIPGSTVATRVKKSSSHGHTVVYTCTACNTTRRIPAPPVLEADNPADDAMGMDTDSHNEQSTTPLGKDDVPKIKTKAKKRPVGRLPPLFQRRGHVVFRGNERLEEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEQ9</accession>
    <name>A0A401GEQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0303780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611572.1">
        <property type="nucleotide sequence ID" value="XM_027755771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEQ9"/>
    <dbReference type="STRING" id="139825.A0A401GEQ9"/>
    <dbReference type="GeneID" id="38777576"/>
    <dbReference type="InParanoid" id="A0A401GEQ9"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="338" mass="36938" checksum="66E20DB6D85A9B7C" modified="2019-05-08" version="1">MSTPPLVLVTGVTGFLGSHVVYQLLEAGYRVRGIARSSKVSMAQEGYAAYGDKYEVVPFDDLVGGDFSNIVKGVSAVIHVAAPLAGRADRAEAIRVAVEGNLNILRAAEKVGVKRFAFASSIITVVSPSDWNQGTKKQALDESSDAMFVYGVAKTISERAIWDFVEKHPDIDATTVNPPYFIGPFALGFRAPDGAISAMSSNELIYRLLQPDWEVNAFGRTVDVRDVARGLVNALKAPTNVGRKRILMSGEWFSWKDAVEFIAAERPELKPRLAASAFKAVPAPPTAIDNTRAKEVLGLEMTPWKTSVLDAVDSLVQLEKEWIKKGLTIRDLYPRWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GET7</accession>
    <name>A0A401GET7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0304110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611605.1">
        <property type="nucleotide sequence ID" value="XM_027755804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GET7"/>
    <dbReference type="FunCoup" id="A0A401GET7">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GET7"/>
    <dbReference type="GeneID" id="38777609"/>
    <dbReference type="InParanoid" id="A0A401GET7"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="348" mass="37631" checksum="42058998E541982B" modified="2019-05-08" version="1">MSEYWVSHKKYFCKYCNVYIADDVPSRRQHESGLRHKGSVERFVRGLYKEGEKKKQDLEEEKREMARVEQAAQAAYARDVGAGLVKPGSGSSAPTPSTSSTSRKPDPKPSNPYANYSTAESLGYQDPDAERLKAETERRRTQGVAGEWEVVAIVEPAAEIKEEEPVPPLAEGDASRKRGAEQDDHEDSRTFKLRKKTVDVGLGEVYDPGLIPIKLKKEESVEPLPTLTEGGSSSHAGTSTPTAKPKWSARGWNRPGERNAGGDDQPGEDGVLAAEDSGVKFEAEVKEQLAISPDVPPADAKETSAILKTEDAEVKVEVNGGATVPSTGSLFRKRKVPAGGAGSRGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEW3</accession>
    <name>A0A401GEW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0304360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611630.1">
        <property type="nucleotide sequence ID" value="XM_027755829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEW3"/>
    <dbReference type="GeneID" id="38777634"/>
    <dbReference type="InParanoid" id="A0A401GEW3"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE80717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="486" mass="52261" checksum="0C74E2977F88BD1B" modified="2019-05-08" version="1">MSTDQLEDEFVAGDIETDPLLVRSPQASRPTPLPKVQLGAVYAIKLILPIAQTQVLPYLNVLVQGLAKSDGAKTGYYSGVVGSATSVAHLLTIYLWGRISDRIGRIPVIVLGTTGIAVFTLLFGLSRTFATVLLTRFLVGIFSGTTGAIHSVVGEITDASNQSTAFPLYDIVSALGFVIGPLIGGTFANPATLFPRWFDSPFWRIYPYFLPCLVTASIAMLTLFIAVFVLEETLPSKRRTKVTYDVLFSEESSFSEMEGEIVQTTQAKPLSIKALLSIPVIRSICASSAALGFVGSCFNTVFVLMAYTPIHDGGLALSPLAIGQALSVMGIVSIFLKLTMPVLLRRFGTLTVFRSCMQSWPVTFASMALLSFVAKQAVAMESKAIEWVAVGFTLFMSRVGCMAFSIIMILTKDHTPGTMSLGTSNGMAEFAQSSLAALGPTVVSSLFAFSASNNILGGQLWVIIMVLVTLLGGSFAERIRKYRDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF98</accession>
    <name>A0A401GF98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="7">5.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Myo-inositol 1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">SCP_0305620</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611755.1">
        <property type="nucleotide sequence ID" value="XM_027755954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF98"/>
    <dbReference type="STRING" id="139825.A0A401GF98"/>
    <dbReference type="GeneID" id="38777759"/>
    <dbReference type="InParanoid" id="A0A401GF98"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="18">
        <location>
            <begin position="338"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="GBE80842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="555" mass="60597" checksum="33C12CB1DFFCF70C" modified="2019-05-08" version="1">MAPYSNSSGLNTPESELESVLPVHPTAARRPYPIVVQSEQTSYSDDFITAKFTNRGASVTVTDGQYLITPSFKQYEFQTARKVSKTGLMMVGWGGNNGSTLSATVLANRHNIVWHTKSGIQQPNYIGSMLRASTVRLGVDPSTGKDVFVPVADVLPMVHPNDLVFGGWDISGATLDQAMKRAEVLDWDLQRQVAPHMAALGKPLPSIYYPDFIAANQEARADNVIPGKDKQAHLERIRADIRRFKAENALDRVVIFWTANTERYSEIIPGVNDTADHLLASIKASHSEVSPSTVFAVAAILEGEPFVNGAPQNTFVPGVIELAERKKSFIGGDDLKSGQTKLKSVFAEFLVNAGIKPLSIASYNHLGNNDGHNLSAEPQFKSKEISKSSVVDDMVGANALLYKPPQEGPVKGTKAAKGEHPDHIVVIKYVPAVGDSKRAIDEYYSEIFCGGRSTINIFNECEDSLLATPLILDLTILTELLTRVKYRDVAGQQAEFSPLHPILSLLSYMLKAPLVKPGTDVINSLNRQRNALEAFLKACIGLEGSSDLLLETRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFU6</accession>
    <name>A0A401GFU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0307620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611952.1">
        <property type="nucleotide sequence ID" value="XM_027756151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFU6"/>
    <dbReference type="STRING" id="139825.A0A401GFU6"/>
    <dbReference type="GeneID" id="38777956"/>
    <dbReference type="InParanoid" id="A0A401GFU6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019296566" evidence="2">
        <location>
            <begin position="20"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="873" mass="79350" checksum="38519E8D3895B40B" modified="2019-05-08" version="1">MHSLFTLAPLLSLAPHALSIPVLPRAPSPQNTVDPVLSTANQLVCNILGVQITDPSTFLAAIQAGTAQPPSSLPLSVAEDLLQQCINANSGVFGALNQNTVANAPASSAAGADTGAGGAPDGASNRGAHSGGASADVGSYSGPSFSGYSGVANSAGQGTGTSSSGTGNSDPNAPAASNDGGNPPAASNDGGNSPAASNNGGNPPAASNDGGNVPAASNQGGNAPAASTLGNPAAVGNSADPSNAGGATSSAGGAPAGGNTNSVASNGGNSGSGPNVNVNSAAGSTSGDPASSNGASATAGSGGNSNSGTTAGSSPGANVNVNSAGNTNSGTPAAVSATANGDPSAADNSGSPASVSATANGDPSAADNSGNPASVSATANGDNTGNPAAVSATANGDNTGNPAAVAATANGDNTGSPAAVSATANGDPSAAANNSGSPASVSATANGQNVNSNTVPATVGNTASGTEGTAGNDANGAASNANGVASNANGVASSNANGVASNANGVASNANGVASSNANGVASNANGVASNANGVAINANGAASSNANGVASNANGVASNANGAAINANGVASSNPNDVASNANGVASSNADGVASNANGAASNVNGVASSNAAGVASNANGVASNANGVASNANGVASNANGVASNANGVASSNANGVASNANGVASNANGVASNANGVAINANGAASSNPNNVASNANGVASSNADGVASNANGAASNVNGVASSNTDDVASNANGVASNANGVASSNANGVESNANGVASNANSVAGNTVSHPSTSTHATADSSNPAADATANGSATSDANANSPSTNPYVTERPTLCFGPLCSTEHFGENPQDTGAHTSIPGVTQATDSADATCGGGAINLCLDLGSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFV0</accession>
    <name>A0A401GFV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0307900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611979.1">
        <property type="nucleotide sequence ID" value="XM_027756178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFV0"/>
    <dbReference type="STRING" id="139825.A0A401GFV0"/>
    <dbReference type="GeneID" id="38777983"/>
    <dbReference type="InParanoid" id="A0A401GFV0"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="522" mass="57238" checksum="AF53931ED0DA7466" modified="2019-05-08" version="1">MEGQSIKEVQVVPTVLDAPPVSSPSDGETLTSPENLTVDAENIGHSTRRLDRKALALLLVQHLSNSWGLRTAEFAIYLFLITLFPDSLLPASIYGFLTTGTAILLSGWAGHQVDIRHNLRLVRVCTLTLKVMACSAYAAALVLMYHSRNLQHPWSSSLARGMFSIIIICGCIHNLAGVAISVAIERDWVTVIADGSSEHLTTINTYMRRIDLLCKLLAPLFVSLLTTAASYPFAAYFLCGIEALCMVFELIWITIVYRRFPQLQAAQAAKEASGVHAAQSSAASSSLKTQVMTYIRDSVSDWKVFTHHPIFMSSVAISCLYFTVLSFDGTMLSYLKAETYSDPFVAGMRALNVAAGLAGTLAMPLLERKLGLVRAGNWSIWSEAICLVPVLISFYVGAPPPGHRAPAWNAALLFGGMMLSRIGLWAFDLCQLKELQIALATHPRRNAITALQYSLQNIADMLKYLLTMILSRPSQFKIAALTSFVSVVVGASTYLAYVRKERGHILHHDFADIIPLLKRTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG64</accession>
    <name>A0A401GG64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0308180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612006.1">
        <property type="nucleotide sequence ID" value="XM_027756205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG64"/>
    <dbReference type="STRING" id="139825.A0A401GG64"/>
    <dbReference type="GeneID" id="38778010"/>
    <dbReference type="InParanoid" id="A0A401GG64"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="94"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE81093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="488" mass="54342" checksum="EFD570F9934145E6" modified="2019-05-08" version="1">MPSSPAYELVPTDANVDSGDQSQPRPRSRRLAATKSLLLALAFCVVAIAAFKAGQWSVKVIPADHTVSPGKPDTEEVGNPSAAPTNDTNMSSGKYSVGYFVNWGIYGRKFPPSLIPVENLTHILYAFANIKADTGEVFLSDTWADQEIHYAGDSWNDVGNNLYGNFKALYNLKKQNRHLKVILSIGGWTYSPTFHPIVVSPALRSKFVASAIRLLEDNGLDGLDVDYEYPQNDEQARGYVELLRELREGLDAHARRKDISHRFLLTIAAPCGPDNYKKLHVSEMDRYLDFWNMMAYDFSGSWDHIANHQANIFGGPISASQSIHWYISKGVPRNKLILGIPLYGRSFMNTEGPGHSFQGIGPGSWEQGVYDYRALPLPGSYMHRDEQALASWSYNFQTKEMVSFDSEEVGWWKGEWIRKEGLGGSMFWELSGDKGSQREGMEGGPGKEAQPGKSLVAVVKEAMGGLDTSPNWLQYEGSKFDNMRKGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGF1</accession>
    <name>A0A401GGF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytoplasmic 60S subunit biogenesis factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0309910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612177.1">
        <property type="nucleotide sequence ID" value="XM_027756376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGF1"/>
    <dbReference type="FunCoup" id="A0A401GGF1">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGF1"/>
    <dbReference type="GeneID" id="38778181"/>
    <dbReference type="InParanoid" id="A0A401GGF1"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE81264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="464" mass="51385" checksum="6EB91EA1423227FC" modified="2019-05-08" version="1">MSSTELEANTTLFTCLSCTIAFHSAEEQREHYRSDHHRYNMKRRVAGLPPVSSAIFNQKVLERRAETAVMVSPKGSTCEVCGKSYTTENAYKSHLSSRKHKENELKAISSPPPKSEPVHEETLVVAPAPVPEADAQAASSKTESAAPRSIGLSVEEEATEEQINQTIDQKIAAARARLGPTQCLFCSESSMSLDANLTHMSIAHSFFIPDAEYLVDILGLITYLGEKIAVGNVCIFCNGRGREFRTLDAVRKHMVDKGHCKIAYDSGEDRLEVSDFYDFTSSYPDATQKTKKKSADGTENEWEDVDESDEDADGEVDEVVEEGVSDGSDDDSDEVPDNQITYGDSHFELVLPSGARIGHRSMRRYYAQSFPRAYRGGKPEDPNSGAALVRRLLADKNSALVPRKGGFGAFGAGTDVVKARNRGEAREAGRHVREFRDQARREAFKTKIGFINNHQKHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGH2</accession>
    <name>A0A401GGH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0310130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612199.1">
        <property type="nucleotide sequence ID" value="XM_027756398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGH2"/>
    <dbReference type="STRING" id="139825.A0A401GGH2"/>
    <dbReference type="GeneID" id="38778203"/>
    <dbReference type="InParanoid" id="A0A401GGH2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="514" mass="56823" checksum="3740D4C0BF3E4B9F" modified="2019-05-08" version="1">MASKDSEIIAVLEKDPGLVEHRSPSGSVVDQDDELLADNVRVAAERKLVRTLDSRLMPTIIVIFIMNYIDRVAITSAKLQGLTQDLHLTSIQYSTVIAILYVSYCPAQIPSNMILNRISRPSYYIPGCVMLWGLVSMLSGVTHNYAQLLVCRVFIGLPEAAFYPGAMYLLSRWYTRKELSLRGAIIYGGLLISNAFGSLMAAGILSGMQGKRGIAAWRWLFYIEGAISICVGIIAIFLLPDYPHNTRWLSPAQLRLARVRLAEDAGEADEDASTDSAFSGLMLALKDPKVPLMAFMNCSQLLGLGFINFFPTIAATLGFSTTITLLLTAPPWILATIVCCVNSWHADKSGERFFHQSWPWWGVIIGYIIGVSTMSTGGRYVAMFLMACGYAGFALTIVWVSNAVPRPPAKRSAAIGIVNGFGNLGNLIASYTWEAQWSPNYHQSMYIGLSALVLSSALAVVVRCMLIAQNKQLDRDELENLQAGKRERIEEAARLEGLTFEEALRRRKGFRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGK1</accession>
    <name>A0A401GGK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0310430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612229.1">
        <property type="nucleotide sequence ID" value="XM_027756428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGK1"/>
    <dbReference type="STRING" id="139825.A0A401GGK1"/>
    <dbReference type="GeneID" id="38778233"/>
    <dbReference type="InParanoid" id="A0A401GGK1"/>
    <dbReference type="OrthoDB" id="3219336at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="282" mass="31072" checksum="BD8488ACAE867DEC" modified="2019-05-08" version="1">MPATRSSRRAQSREPLTSHPINAGASSPDIIILSSDDELAIPKQNRLTPKKSKQRVRSKPRISADVIVLSDDEGPEASTSTVPRGTTPSLRQQLKEAKEMIARLEAEARAWEQKDKASQGLLPALDEHVNCEVCTLKMWTPATLACGHTFCQSCLQDWFTTALTQHMAANPDYDAQPAIIQQYKAALQNPNTTSQARRQLANHINELLEHIPQPQYTCPSCRAPVKSKPIEVFRLKHITRTVAAATGETSPKKAAPARTTRGVANRRAAADGPWDGFFPWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHC5</accession>
    <name>A0A401GHC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized FAD-linked</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0313260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612510.1">
        <property type="nucleotide sequence ID" value="XM_027756709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHC5"/>
    <dbReference type="STRING" id="139825.A0A401GHC5"/>
    <dbReference type="GeneID" id="38778514"/>
    <dbReference type="InParanoid" id="A0A401GHC5"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019112664" evidence="6">
        <location>
            <begin position="23"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="132"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="610" mass="64598" checksum="82AEF1954B0AB54B" modified="2019-05-08" version="1">MLRSRSLVSTLLLAFAAFGVHAQTNEDSSYTPNYVTLSSPSWPSAASWNALNSSVGGKLSALRPWTAVCYASDPLFDESSCQTVLSNYSSDTTREAHAAALLWDNWETCGYGDGCGLDVLDPKIVYNRTCEQGSIPPYSVQVSNAQEISAVVNWAVQNKVKTTVKNTGHDFLGRSTAPSTLQVWTHSMDSITYDAAFVPQGSSSSPVPAVTIAAGAQVENIYAFLEANNISAVLGGCLTVGAAGGFVQGGGHGPMSPAYGLAADNVLQVEIVTADGTIRTINVVQNSDLFWALRGGGAGTYGIVTSVTLAAHPPTTVSTSLLTVTPDPSLNASELAIGWINLTAQYANEWNENGLAMTSVVSSTRYYLNLYWPSDSAPLSMLYPFFEAVLSNSTYTIDSNTTADAAFSSFTAAVIQSIDPLFDAFNIYGTNSHMASRLVPYTYLSSSSSSGQVAQAIWEGHQVLNGPLTGGAAGTPGEVPVVILGDMPAATRGQSDATGANPGLYEATWHTVYASVWFSAATEATMEAVVDATHAATGPLTKLGITTSYQNEGDAYETDWQNAFFGSKYEKLLSIKQRYDPSNFFNTWQGVGSVDSLDAWQCFHAAAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHC6</accession>
    <name>A0A401GHC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0313250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612509.1">
        <property type="nucleotide sequence ID" value="XM_027756708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHC6"/>
    <dbReference type="STRING" id="139825.A0A401GHC6"/>
    <dbReference type="GeneID" id="38778513"/>
    <dbReference type="InParanoid" id="A0A401GHC6"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="48836" checksum="F6390C12875377FD" modified="2019-05-08" version="1">MSTLVKVDSGSGGLGDTTPGMIDYSGSWYFDNTAGVEAYDESLAIARSAGAGASLQFVGTTVAVYGSVYPPNGCTPPVSTYSVDGSTPETINAPSVNEAINTVTFWANTYLSNGTHELVISVTQASANCQYMLDYISYTMLDSPSGQPSSSSSSASASSSSSPSSSPSSPSPSPSPTSSTPSTPSSPASVQPSSQSQGSSASFQFSSLQSSSSQPSSGLSQPSSSHLYTSSGSGQNTTIGGGRTAGSLSVTATDSQGSSSSAAASGTAAAAVSRGSSTPIGAIIGGVVGGVVGLALVLAALFFMYKRSRAECPDEYFYKTPALGYNAPDGDDAHALSGRTVAGSGSQMAQAEGGSATRRNSLLAWQTPDASQSRISLRLPALDSAPIMPFTSAELASASLSSTPRDVPPPSAEFLEGIPPDDPGVGPAKQGNEVASSSRIPDPPQPPVAMRRSPNIDSGLRFSPGVAPSDVDDSLLDLPPMYTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIZ2</accession>
    <name>A0A401GIZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0404720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613006.1">
        <property type="nucleotide sequence ID" value="XM_027757205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIZ2"/>
    <dbReference type="FunCoup" id="A0A401GIZ2">
        <property type="interactions" value="662"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIZ2"/>
    <dbReference type="GeneID" id="38779010"/>
    <dbReference type="InParanoid" id="A0A401GIZ2"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="141"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE82093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="473" mass="50115" checksum="CBDF72B973EB84FC" modified="2019-05-08" version="1">MNMFGEQDPFGGGPAGLFAQLAQGLGGGLGHRMGRPPARAYDEYLRAYSAAMLPGKERDNVSYGGKIIMPPSTLARLTSMDLESPWMFKLRNPANPAASTHAGVLEFIAEEGCVHLPQWMMSTLRLNEGDPIRITGAELPKGNKVKLQAQSVHFLEVSDPKAVLEQALRHFSVLTQGDIIEILYNGMVFGFLVMETYPGGEGISVLDTDLEVDFAAPLGYVEPERPKPAPPATMATKLNINLNDSSPGSSRPSSSLAGTFAPGTRGTTVSKGGEQWESFKGKGETLLGRKTKGKGISHRRVQEVADNAKIVRTDKARIVTNDTLDSDVPVPAPLNLPFGQLFFGFNVPPFTPPASNPSATQVQAQAFSGAGNTLAGPSSSQGQSASSPSPKGKSMEEEGSDVPSSWGVGGQRLGSRTAPRPAASSGPRGAGGAIVPVLPQRSGRQEQRQKERSPSPDWGVDDDDVIIIDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ32</accession>
    <name>A0A401GJ32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0406030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613133.1">
        <property type="nucleotide sequence ID" value="XM_027757332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ32"/>
    <dbReference type="GeneID" id="38779137"/>
    <dbReference type="InParanoid" id="A0A401GJ32"/>
    <dbReference type="OrthoDB" id="3002933at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22461" checksum="2671795191B545A5" modified="2019-05-08" version="1">MSNTDFTHGSLYLAGFAQARAPHVGLIIPTSDVLGTLVHIRVDRETSDVWTYQCRAQRISGDMFMSSLLKLREASAGAISVEQLQETAASVSAPRNDDFGECLPWSLRVLQKLHDMGLLNVMDIDGLGREFEEFAAGNQAYARRDRFPNIAVSHFCQYNNPPMVTADRLCHCQSELSSAQGSRQANRPTVTETVRQISCVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJA6</accession>
    <name>A0A401GJA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0406250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613154.1">
        <property type="nucleotide sequence ID" value="XM_027757353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJA6"/>
    <dbReference type="GeneID" id="38779158"/>
    <dbReference type="InParanoid" id="A0A401GJA6"/>
    <dbReference type="OrthoDB" id="2816594at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="73" mass="8418" checksum="ACD708FF26402852" modified="2019-05-08" version="1">MCHRRLHFYKSSGCGHLTFTGENNIDCQSWDCFLSASHNCGSTSGNICRCRRYYTQPERIVDQEVPGKCPRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJG2</accession>
    <name>A0A401GJG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable catechol O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0406920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613221.1">
        <property type="nucleotide sequence ID" value="XM_027757420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJG2"/>
    <dbReference type="FunCoup" id="A0A401GJG2">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJG2"/>
    <dbReference type="GeneID" id="38779225"/>
    <dbReference type="InParanoid" id="A0A401GJG2"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="223" mass="24094" checksum="463FACCBAC5E2EBD" modified="2019-05-08" version="1">MSEEITPELWERSDAYHNSFLIGPDEPLEHARTRSEAHGLPAIAISTAQGKLLNLVARSISAKRILEVGTLGGYSTIWLARALPEDGQLMTAELNPKHAEVAELNVAHAGLSSKVKILVGPAAETLANLHPEQPFDLAFIDADKIGNLAYFLEAKRLVRKGGVIIVDNVVRGGSVADPSTKDNNSEGVRKLLNYLKTDVEVDATTIATVGEKGYDGFLYAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJK4</accession>
    <name>A0A401GJK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0407250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613254.1">
        <property type="nucleotide sequence ID" value="XM_027757453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJK4"/>
    <dbReference type="STRING" id="139825.A0A401GJK4"/>
    <dbReference type="GeneID" id="38779258"/>
    <dbReference type="InParanoid" id="A0A401GJK4"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="310"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="464"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1126" mass="130208" checksum="1DB2F42C1536358D" modified="2019-05-08" version="1">MSRFRPVRASPPPKSSAIPAATLAKDLDNSRSSTISVPELVDLSPEEVDFIDAVIERAPASATTFLTVFKAYNDLLQERGLDPQNEVVYYGKLLKLGTLRGKNWGEKWAMIKQQQGYVVGAGGARRTTRVTRAAPASTRISTRLTAGINNVRPEDTLTLHSHPEDADVAPESPVTALQYHHIPQATRPPISPTFTTTTTNSLGLDTGIPAASYNPRRAFASRPTPTRQLGHWDAETSEATGDSAHAPSTIPPSYGAAMRDVVPPRHIALAKLPLSRTASASPPSIQPIALRRLVPRGKERRDSVVNEEDAWSKIKMAQDEQDADRFRDERLLERCWDVWRQGYQWIITTHEQITEARDHLILRIALQRWRERTAEHHELYKRVYELSNNRRLKLALHVWKTKLKEKKQANWRNDMRAKMKTVRENHETKLVKDAWAKWRQSYQSHLSGQQYSEKLVIRFLRRWKLRLGSLDQLDAAADHFIYAKEVEQVSKCWDMWRCTMEVRKAERTITERVGLRVMGDVMDVWRGRLHDNRVADGFYDVIVVKRALGAWKAARDRIRTLESRASKHLARQNDVLVRAVMRVWKAHERGKLLDRVRTARLLKQAVAVWKRRVRQQRELEDLAVAFSMRSSSTLAFSSLQKWRQVHTTHRNAHAFAVHYRSAQLQYKMLLVWRLELRTKLRMIKQAKLANKYFVLRTFYNKWAAKLVQRRLETKLKVFEGQIVKKFLEEWQKATQRQQQRKLAEMIIQQRIALRILSGALTHWTNHVANIKFRELETTQKVESTILANAFKKWKGLCIRHVEELSLMESYQDVKREENMRRMFYRWLTAARKVRHRRLYLQEKEEEMKLTVVAAAWDKWRERFQDIRLQPVADDFLMQKETNTMFRAFGIWHSKTKSLPAVRFHASRAKAKAWQIWRDAMPRALQARTARDMDRRSVLAQTFDKWLKTYKTKIELKAVARARYLRLPTAAPRQVIENPRFTMGTQPPRSVFPRTLRSSSPGKDPSNAAAGPSIGCPRPGKTGIVSLLTSKLRSPERSERRLTRTRASISPSRPKLSTRGTTTRDPSPTRAESSYGGGMRDDERPARSVASGPSVGEAARSSLWQELREIRLRAGTLSERSRFREPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJL9</accession>
    <name>A0A401GJL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0407390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613268.1">
        <property type="nucleotide sequence ID" value="XM_027757467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJL9"/>
    <dbReference type="STRING" id="139825.A0A401GJL9"/>
    <dbReference type="GeneID" id="38779272"/>
    <dbReference type="InParanoid" id="A0A401GJL9"/>
    <dbReference type="OrthoDB" id="3269397at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="583" mass="67121" checksum="4682C7ED6D3C837B" modified="2019-05-08" version="1">MSHLPPKPDFDQPPPPRYPPDSRHYARPSRMSTPDRTYPHRTRDSYVPRSPRSRPTGDTYIAPRPMDTYRGGSRPPMVDSYVAAYDHRRDDDRYRDVHRDRGPPGHRDWRERDHPPHEYKYVRGSSRERGAWNREREHDRWRRWEEPDRRGYDRQRRERDYSPPRRQDIKRERVRDSPERTWISRPSKSPPRRMAPDDQAELSPSRKDRSPPPHIRTPSQSRLYSRPSSPTYARTRDQPARGRSRSIDSRRDYSAPRSPRVDDRSLGTSRRRASYDTHRGRDMSRGYSASPRRRRDDSSSRDRSLSDTDIHEAGELGDEPLRSRTLSRSSSPSRSRSRTMSPRRHNLDRPRSRSAEVISPRSRSLTPPIKREPSEQPSPIEPPHSDAKGKRKEVVHVYDHDGDVKMEDILSPSGSTREAFEGGSAPHHRRRSHSPLAPLRSMLSSPVSPRTPHHLPPRPDWSRGTAPAPASGTPAEGGRSTPDISGHNLVIPPTKSTLSVMPEEAEIARLRSQRTHLAAEYAALSRATKRTLHELKMASTELRFAERRRALADAQLEKARAGILGIDYTRKIELAGTTNAWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJQ0</accession>
    <name>A0A401GJQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0407630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613292.1">
        <property type="nucleotide sequence ID" value="XM_027757491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJQ0"/>
    <dbReference type="STRING" id="139825.A0A401GJQ0"/>
    <dbReference type="GeneID" id="38779296"/>
    <dbReference type="InParanoid" id="A0A401GJQ0"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="413" mass="45855" checksum="AACC78BA22015AB8" modified="2019-05-08" version="1">MKPNAIIFGGLNTCSRSLAAYLVPVDGESLVENLRIIDKYSVAPPTTYIGAEFPKILEKSNVEYRQANLTVAAIVASCFDTLEGQEAYTYVFDLTGELQWNRPDQVQITSTFKVSRLIGLEAAKRKVAAYVRIQHPFYQCKEKGDHNEGEDVRPDGVLGTWWHETLRALGAIEGLNLVVVRTGMVYGPYIDYGQVISYTVIAAVYGYLKQPLKALWSPGKYPVNTVHIDDVVAAMWASAEWIARVGRQEANTAAGEVIPFKNKESVTAEVEGMIAPSQKVVVPLFNIVDDANSTLVQAASLIASVFGTTFEFYNFLVNTMAKFQIGDYIEEINEVHVSGWTEMVTKSNPPVPNTHFSAYMDENSLAKHVVAFSNAKIKRVLGYTLCRPEFDKASIQEMVEKLQAEGSWPKFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK38</accession>
    <name>A0A401GK38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0409070</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613436.1">
        <property type="nucleotide sequence ID" value="XM_027757635.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GK38">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GK38"/>
    <dbReference type="GeneID" id="38779440"/>
    <dbReference type="InParanoid" id="A0A401GK38"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="12">
        <location>
            <begin position="475"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="11">
        <location>
            <begin position="664"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="10">
        <location>
            <begin position="859"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="9">
        <location>
            <begin position="1156"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="13">
        <location>
            <begin position="1420"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="8">
        <location>
            <begin position="1768"/>
            <end position="2126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE82523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2133" mass="239890" checksum="EB98B71B85E3819A" modified="2019-05-08" version="1">MDNPANPNIHTIVKAQIVFLLSTLTEENFERNQIEIRSLSEQHGIDTYLHFIRRLIVHSQSRLSSSAPPSAYDPSTILTFRLLVQETQRLARDPFLADRFRDGIDKGEGDVFRHFDLVRFADRVGLRPLERLVLASSIAVGSTRKELASQAANMIHTEFENAVLALCQHPSFDHADLSPNQVTKLLSNLLSEPPHDAPILDSTQRQALIAAAQAKYGSEIVSPILQRILPNLSLPPGTTLVQALVQLGGDITSDPDVVRALLTRFGISEASPPSDAQVVEIVSSLARLASEGSVICDVGSLVRALSSLNVNINWASAIKAFDWPDRQGVDTATLKLLIAILLNCPRDAEVHAVTGFWQTWSNPLYQLRLLDALLSLPADTFNFVSLPGHRIVTVDDVAAASPTIKSLAANVQGHTWNSLDLFEVLVSLSDSDSPEVRNFVREMLDKAVKISAELVHMGLLQVPQTTWGEIRLEYSQRLLAMFLAGHPNHQLVFMRIWQIEPTYLTNAFRDFYEESPLNITRILDVAQDLKILDSLLEVRPFTFALDVAALASRREYLNLDKWLADNVTNHGADFLHAVIAFLDLKMESEKATRISDPAVEHRTMPLNPQTITIFLRVLRNSSNIMHESDVDYCLEVRNACLQIHPRLMNLVPGSDAEPGFTVVNYTTEIEAEVDSIYKQMYDEQITIDDVIALLQRNKASSNPRDHEIFSCMLHFLFDEYKFFQSFYPPRELAMTGYLFGSLIQYQLVDYIPLGIAIRYVLDALNCPPDTNLFKFGIQALSRFESRLSEWQPLCQALLRIPHLLEAQPELAASIQRAIANAGEDVNNTVDLRTLTATNVPEPLAIFTAIQPDPVEGEPESPPEEISDKILFIVNNLAPSNFETKLVDMQEQFQDEYSWWFAHYLVDQRVTTEPNNQQLYLRLLDALGVQKLFRLVLQETLIKSASLLNSEKTMLSSAERAILKNMASWLGTITLARDHPIKHRHLSFKDLLIEGYDNGRLIVAIPFVCETLKPCARSKVFKPPNPWLMAVISLLAELYHFAELKLNQKFEIEMLCKGLDIDLDTVQATTVLRNRPLTEGPPLPDYVVADINSIPIGGYNSSAQTQGDSQVLPPLTPGSPSETHRVLGAHIENILCNILPSVIIDPQLAPLHTNQLFKRAVQMAIDRAVREIILPVVERSVTIAGISTRELVAKDFVTEVNEDKLRKAGHLMAQKLAGSLALVTCKEPLKSNLGGHIRHFLADFGFSDQMISEQVIFLIVQDNLDLACQAIEKAAMDSAIIDVDDGFAAAYESRRRHREQRPGQPFWDRSIPQTSFVGTLPEPLRIRPSGVQPVQAVVYEDFGNLDGLISQSVVQESSLLDVRRRGFISRPSSTVSFPPNDHMGSSVYASSPVLDQHAPGQAFLRHQEAMDRFNAMVKDLEALLLQLPIQSLAALPSGHDVRHLVRQILLLAADSIERHRTPLLMSQKIVQLLYKTPSQLGREIYVALLHQLCHSFEDVAKEAVTWLIYAEDERKFNVPVTVTLLKSGLINLPQEDQQLAKFLYTDPRPSLLTFAADLIRECLSSDPPIASQSQFVYTLEILGQLAQSGKVNEEVHRLLDDLRGVRRPSVTEGQVVRQASVKPETEQLREKLFIWFQQWVNIFQRSHSPEKSFVPFITQLTKQGILKVEDVSSFFFRVCAESSVNSYIKCMNSGEFAYSFQALDAMSRLIVYIIKYHGDASGVNNDQAKVHYLTKILSIFVLVLSNMHEEQGALFQQKPFFRFFCSLLNDLHSLEASLGSAYFQLLLAISDTFSSLQPTYFPGFAFSWMSLISHRLFMPKLLLSENREGWSAFHKLLLSLFKFLSPFLKAADLEPASRDLYRGSLRLLLVLLHDFPEFLSEYYFTLCDVIPPRCIQLRNVILSAFPPSIILPDPHLRNMDFDSIPEMGPIPPILSDFASSLKTDDLRGYLDQYLLNRGSPTFLPSLKDRLRLTGVSEGSPETYNLSLMNSLVMYIGVSSVAQAKARSGSSLFVSSDPGVVALHYLATNLDVEGQHHLLSAMVLHLRYPNAHTHWFSSLILHLFTEIKVDQFREVMTKVLLERFLVHRPHPWGALVTFIELLRNPKYDFGSQDFIRVVPEVTLLLETVARSIFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKM4</accession>
    <name>A0A401GKM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0410840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613612.1">
        <property type="nucleotide sequence ID" value="XM_027757811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKM4"/>
    <dbReference type="GeneID" id="38779616"/>
    <dbReference type="InParanoid" id="A0A401GKM4"/>
    <dbReference type="OrthoDB" id="2802734at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="394"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="761" mass="84799" checksum="1658836989788833" modified="2019-05-08" version="1">MTNHIVEIGLEDFMAEFVPGPDPSYEERSNFQSFECVKLDGLETDMYPGLCKVFQSVLNAVPQSGLTARDTGEYLDVTGSEVASDENITKFGIGIYPTTAAAKEAYSVPTKQLMRGKSAQRQKYYMARVSWAWTCVPIEAKSNHQRSAFEFNDPGAHFLHAHSHDGLRTLGQITEHAAQILLRQHRLFCLMVFICKSGARLIRWDRAGGIVSKSFDYIQEPETLHTFMYRVGKMNDSQRGYDPTAILATPEEVAEMRSCESRLNEYHKECLREAMLDGWPIYKIEFKADDVLSETGKTVSPPSTSKRHYLVGRARSSSSSLTGRATRGYVAYDMATQRLAFLKDTWRTDSDKVKPEREVYERLYQKGVRERIATLICGGDVGESVQKTRTQEFNARIMGRIHYRIVVKDVGRPLEDYADVREMILVVRDAVIAHRDAWVSAAILHCDVSANNILISQDPDAEGYLTGTLSPAGFLNDWDMCKYKEHLDKGASQNTRSGTWQFMSALLLRYPTVKGHEVSDDMESFVHLVHWLALKYHPHDLSGSPLRTHIESTYNECDRTLAGHYVGGTYKFSTIKAGLVPFDVSGNPALSNLLRSLIELCRRHYAAIDIDALGPIHGATTTTPSAPVTFRTELPPGFDIVTPAALIPRPSDGQLLLADHHAVYVAFTAVVRDNGPFWVSDKVENKFKPFTKGKSLQESFQTGTSVGSEGKADDFTEDSAKRQKTQGSKSGACSSRSRATGSLGLNASQLDSMDEGQDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKU1</accession>
    <name>A0A401GKU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0411730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613701.1">
        <property type="nucleotide sequence ID" value="XM_027757900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKU1"/>
    <dbReference type="STRING" id="139825.A0A401GKU1"/>
    <dbReference type="GeneID" id="38779705"/>
    <dbReference type="InParanoid" id="A0A401GKU1"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="276"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="686"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE82788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="719" mass="78434" checksum="7B51ED807DE88004" modified="2019-05-08" version="1">MSPSSSSTPSSTRSSHLSVLSSSSSISSPTSLPSPLPSPSVSTSSIGSKTHAFFGSPFGGGDSPTPHPPPNPPTRSISIRSHASTSTNSDDGYDETPKAEPNGPLRSLNADFFGPSLLPTPPPGTPAFPRSAFASRENSPRKPILPPLSRFFPSRRRYNEHDRDEAQSPPSRGFFQLDATPPPHAYKDAPWLAEPYTASPVGDKYQHADSHMTADHAETLSDSSVLTTPIPKPEQSSYVTAKVNPAPEPEPVLQAAALPLAPLAPGVLIGAPSLELELVRRLGQGAFSSVWLACDVKGQLGAFELSRKTSLLRSKSERRGRARKVDGLRPKTKLDEQNDGMKRVRKEWNGDASAVVVKESTAGRLVAVKMTERSMCEKNSRTRVSFVREVEVLRHISHPSIVSYLHSFSTPSHHCLVLEYVGGGELFDLIDNAETHARLDEPLLRRMFGELCRAVGWMHGVGLVHRDIKLENILLTTSPFTSPLPAAPLIKLSDFGLSRFIDPAQPMLTTLCGSESYAAPELVTGRPYDGRETDAWACGVVLYALATRRLPFDLPMANVAHREVVVGEARMREVERRERRALLMRIAKGEYSWPDDRASDCADEQSRETRLGWATGPALAHSAGIRRVVGRLLVRDPHKRSKIIDLWEDEWMHGEGAPPPPLSPVSPDLDHKPDETPDIAQTESPLDPDGDDQFLEADDDGVLVDSHDIVPGSVAHQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKW5</accession>
    <name>A0A401GKW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease III homolog</fullName>
            <ecNumber evidence="12">3.2.2.-</ecNumber>
            <ecNumber evidence="12">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="12">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NTH1</name>
        <name evidence="15" type="ORF">SCP_0412080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="12"/>
    <dbReference type="EC" id="4.2.99.18" evidence="12"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKW5"/>
    <dbReference type="FunCoup" id="A0A401GKW5">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKW5"/>
    <dbReference type="InParanoid" id="A0A401GKW5"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="14">
        <location>
            <begin position="197"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE82821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="427" mass="46475" checksum="C318EB6D722C775D" modified="2019-05-08" version="1">MDVAGLLCDQPATIFGKTNLLRRTANRAPSMPAMKRSASPSLIARPSPYHTSVTLFEPAADGSSSESPLRRSKRLKVLEKSETREVEFTAVTSSPKKQSTRVKAETTSSKANIEVGTCRPSPVKAKRVASPRKPKPVPQSLEVPHPAPARWRETYDAIVDMRSRIVAPVDTMGCGRAQLGETVPRNQRFATLVSLMLSSQTKDEVTSAAVSKLREALGGSVNVDAVIAADDSTVSEAICKVGFWRRKTQYIKQAAQRLHDDFESDVPKTVDELCSLPGVGPKMAFLALHVAWKVNAGIGVDVHVHRITNRLGWHKSPTKTPEETRLNLQSWLPAELRPTFTGLLVGFGQMICLPIGPRCDSCELSNGLCPSARVVTKSKSKKTVATASGSARPHIEIKLEEDQKTAASATILRDLPDDLIQMKTESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLP7</accession>
    <name>A0A401GLP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0501700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614036.1">
        <property type="nucleotide sequence ID" value="XM_027758235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLP7"/>
    <dbReference type="GeneID" id="38780040"/>
    <dbReference type="InParanoid" id="A0A401GLP7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="72" mass="8114" checksum="5FD866868A011FE3" modified="2019-05-08" version="1">MARISHLSSSPSNYVLYQYLKRDRGVDALAFELPPSLLVNIHARAVSIRTSCIRGIYPNFLKSQTSPPFEYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GML9</accession>
    <name>A0A401GML9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0505070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614371.1">
        <property type="nucleotide sequence ID" value="XM_027758570.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38780375"/>
    <dbReference type="InParanoid" id="A0A401GML9"/>
    <dbReference type="OrthoDB" id="3254696at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1432" mass="158150" checksum="1C9AFE6C5461926B" modified="2019-05-08" version="1">MTGSIAPTGAANKDTSTIQSGSGSGGSGGLNLPGPAPLTTEEKKTENLARVARNLLLQQRRDAQETNVPADEPLLHIISRPSTPTPTLPPTPFSSANNCVGLLSAFSQFSPGSQKKVQTLINSSLPLPTNAFPDSVPKLLFSVERERPSSSTSHTQSFGIHPFILNLGQNGVHIPLSLFTTSATNKLHNHATSIKQNIVYNSSGAKCHLMDLTQFQAESEMDVADWHEAWNRYNPFLRTHADKAVAQRWEDHYHFLSKQDDFKRDFRAILTFDIEQRTRYSISPEAHNEDARHAHSPPGLTGMPAEAVGHSSLMIETPVATLATPPRRSLPFETARELTPGPLPSASAAAGPDTNSLNARKRQRRKASKHSRDTSITSSSYDPTPPLSALLSSSTPPNAFASSITQNNTSAPFAAPPSMGPVRESVRNEGDAHLLLGAQSRFLDDFEEWHPSPIFSAPDELHVYFDDLRIESSPFDQDPDFSLVLTPYSAPAFQRYLDNASLLTRYPELCFKLTYGFPLGNLAPIIESFTPNNLLSANVHTEVIREYISEELALGRFTGPFTRAQLEAKIGPFRSSPLQVATKVGACGEPDKFRICRHLSYKGTLGQSVNDEINAKDYPTRWGKATDVAKIISTAPLGTQVATLDIAGAYRTVPVKPDHKRFLVVLFLGFFYMDHNVPFGLASASGLQGEIADATVDIWESVAVSPIVKWVDDFALFRFPNEIGPFTENGFHYLYDLTHAKELIAPLCIPWHSTKGQEFADSFDYVGFHWDIVQRTVSLSERKRQKYSTHLLLFLQTYENSQVPKKEAERIIGKLSHITFVHSHGRSYMSNLYAWLRTFHNDFVPRYMRSSVISDLKWWSTQLSIPSAPRSLAPRGPTRDYGIWVDASTSTGLGIIWNGYWAAWRVVDGWKVPGRDIGWLEGVAAEVAILIARELGIRDADILIRSDNEGVIGAFEKGRSNNVETNLCIRRSEEVFRVTGLSASLIYPPSSPMNDSSPIARLLQDVDIDAEAAAFFSQVNSDVRHVATLPPPGGRIRIPRRPSSLNRITPSSHRPLVLASDRVLLWTTPHSHSFQRSLDSLLPSTAVLKLFQVMLCSLDESTRGNYGAGLLRFTQYCDQHRIPELQRMPASESLLSAFAASAAGAISDNTLSNWLAGLHFWHTVNGAVWHGHDMLRHVRCGVAKLVPPDSKRAKRPPVTIEAMVILKDGLDLSNAFDAAVWALASIAFWCCCRLGELVIPSTNLFDPLKHVSRSVLPIAFGRLANGAEFATFHIPWTKTTLQEGADISITARIHSTCPLAALRHHLSCNIDIPTSAPLFAFETAAGGWSPMTKHWFMQRCNTIWVSAGFPDMPGHAFRIGGATELLLQGVNPDVVATQGRWKSQAFLEYWRRIESILPLFISNASHSSRALHIGSAMDSFSRRHRLVSCAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMX3</accession>
    <name>A0A401GMX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0506230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614481.1">
        <property type="nucleotide sequence ID" value="XM_027758680.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMX3"/>
    <dbReference type="GeneID" id="38780485"/>
    <dbReference type="InParanoid" id="A0A401GMX3"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF33">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="1935"/>
            <end position="2152"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2271"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2736"/>
            <end position="2766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2736"/>
            <end position="2758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE83568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="3006" mass="341243" checksum="5BC935C35041F2CC" modified="2019-05-08" version="1">MIRMLDNLRQVEGYEALPAENIGGQITCMHVGVATFAKESVVFYIRAQNAAIVVRKFAQEFVFESFEVAPSAADVMKATGKLLCSYPGPAIAVPKDTVEDVHFVKELSSFLAQMSVDELDSAATTRKAGSTVVEKRDSASPGYITQLLTGILRGVGRPADVNRISKRINDDVLWKDAYLPWRRSPLWLVIRVALQTSLGRANALSEYKSFMVFFMSRLLRLTVREQFASDRLYCFRAKLSRRLYKLGSSAPLFISQEVKEAVDETESHLQQRWRKIQEQQAVSPPWSPSTLDLQTDTHLTLSNSRDYISKCLTITNTASAACSFEPSHTRRLRDTHCCDFRTFDEGALPTAFAANGDIHVALADFETLVQDRVDNWVAECLHEEWASIKLAKCIEHYSQAAQGAYDGNPEDQSIMLLTIFELWVALDKLAVTQCQLLRRYSPEIPQSLFHSLVLHKTVSLQHLSRIETYLESRHEHADSGSIFCDEVNSTSFAVRFYETSSELQALKERIVAEANCKRDSKRAELEERNDAHHNLMIEANSLEHECDHLRGNKAKRKRCRKCRLTWKARTMTIVPHEWPLPKVALEVQATVFELQCPIPFRTWRSTTYEILNDVCQDRHRSKASPPMVLKDYGGLKKYLKSQAVMSWFSVASSTKSFIQAHYGTISIPATEASVFVNNGLTYRLYDARRDLWAADFLQNYSKVSQRCTFSLPLTDPYQSMQYAICGTAHYPNAVLACQSECPMELDLHEYTAFGLLRSGGLLQWLNILRGIRARELSFEREEVHLLLMQAIWQVGPSQNGVRVWHVEPSNRVFGLLLLTELRDLLSSIEGNWSNVTSAKSIIMLSCRLLASSVDRYVRQSAYGLLRCARRITFRWLHELSEKLSKAVCEDDIFSLQLRVCAMAAICRSTYDVGLGDLEALLASEEDVSVLIQCAVHLRDNIPTTEKDIPSNLPLLLERDRRLSHFLEPALRDVIRRLSGVLDKPLAILWQEFQEGQTWVQMQEPNDRWMTVAYGRTTVHINVLNGELLKILDVIPSDMPGMDFATRADVFGFHVHFSLDCGQLTVKTTSDSTVYELIPHSKFMRDLPTPLIVDYVHWLKIDTQDPKCAEIELRPLGDLWTSSPDIWRIQFSMNGNSTMSQRGMQLLDNRSPAFAMISKRLQSLECPEHLVITLSAENCLLVDLPRFELSFVVEDGELMSRNWRGLIVDSNQSTKTMLGLSSQLVLTQRGNAPSLPPERHVVIPIGDIKFCSSGHHVKVQVEAGAMSRRHYHKYRIDPNLGCVVGNGTLLSKLYQVYLHALTSHCLPDPLTGQTGTEEALSELRSARCLSFQKLGPDEVTLLTQIGALTPERQFYPAHLRVMQTVHWCDLSPISQRTDFWDCTVLILKHAQNLTDIFYPEKDMTSLLSDALQKQTSDQHLQNRAALRTSVIYGREYSTWTTTDGDDLPYTTRDLPQDSTSEKEVATVSALVHSWPTRLPTTSDLLQVMVSWQEPISVAEDIVLSYRSDWLSPALPAIWLSVYEQCRASNADVQPKLLFILSAMSYKLNVSHPVQLVGTILAFATTPQFRSLQLPSTLSASYNLADGFAPREVELNTLAITFTVPYDPWTSSLDLSRSAFETEDKFAERRRSHHDKFCASKARELVGCLIRQWPCHTPSAPPGYSSSINITEFMLKAKSKFRSWYQNRELENHLIQVQHILHQVREQSAHVKVPHYVVHTPLRPTTAPKCFVDATGLLKREAPALEVLDVQAYLGETFYRLSADSFRTDELRFLIREFERHPSSSFKQHYGQHLERSRAILEAQAGSTVPYFPPDTFESFKHYRDLCHQAYSCSTATIQQFLGPRSDVERVVCISGLWPRLSAKSLLRILASTSRTHRTLSKEWEQCLVSYARTYLQFQRSRRLIEYLQQKRYEELLKELDNQEYRIQPDDSGSALNTDWLLVQIENDFLMRPLQQSIAREMIAPSSGRNTVLQLNMGEGKSAVIAPLAATALADGRKLVRVVVLKSLSSQMFHLLVDRLSGLANRRIFYLPFSRDIRMGPQVVQRIRSLYEECVREQGILVAQPEHILSFKLMGIDHSKDCVSQDGQITEALLELQHWLDTVTRDILDESDEMLNVGYQLVYTAGQQRPIEDHPDRWKTTQHVLSLVKDHSSSFHILHPDEMEFVPGTGGTYPMIRILHDRAWEGLATDVARHIVNTDPTLRHLPENLREAALMFITENVSSVPGSRVRLLEEHCKGDGLWKKLLLLRGLLGHGLIGYVLKEKRWRVDYGLDLTRTLLAVPYRAKDVPSLRADFGHPDVAIALTCLSYYYGGLTSEQLDTCFELLLKSDEREVLYESWVRDNDAVPPFLRQLIGINHEDSRQREHFLVPLFRRCSAVIDFYLAEVVFPRYAKEFPEKLSTSAWDLAEIKTHVTTGFSGTNDNQDLLPSSITQHDPVDQLSTSARVLAYLLQPENKTYICVGSESTSGRDYLNLLVKQDPEVRVLLDVGAQMLDMENAELAKHWLSLTAHIAATVFFDEQDELMVLTRSGTIEAFVSSPYSQQLDQCNVYLDDAHTRGTDLKLPRKARAAVTLGPKVTKDRLLQGCMRMRKLGNGQSVLFLAPPEVDRAIRALSGTKDAVETIDILRWAMVQTCAYIEHHVSHWAHQGIGYKKRRTAWNQFKARSSTSPSGSIQLATSQMPSLRSAWLSPEARPLEEMYGFSAGISNALSINDAMFDNPELRDRFQLFGVTSLLDPHMDEEQEREVSQELEQEREVERPPAAKPATHHVHSDVENFVLTGMIRLGPAFVPLFSPLDGLPGYPGQHVCSDRILATKDFATNIEKQRSSHHPSDCMAPVNWIISNTSQSHLVVFSAFEVNILLPMIRQSTVVCLHMYSPRVTQSMKPLDALNFYCIPTLRKSWQPEPMDICQLNLWAGQLYFTNHEMYSQLCIYLGICAEEPPEGARVQVDGFIEPQDRIEPMKSLCPFSKSPIPLMKELVGLRRKGMGYRSTHMGKVLHSGFLTSKDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNR8</accession>
    <name>A0A401GNR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0509130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614769.1">
        <property type="nucleotide sequence ID" value="XM_027758968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNR8"/>
    <dbReference type="GeneID" id="38780773"/>
    <dbReference type="InParanoid" id="A0A401GNR8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="10052" checksum="500F3A3C91C17172" modified="2019-05-08" version="1">MTIPFTKYVASIALIFSGAYIWDKRSPSEIASERTDPAYMLQKMDVSPLLSYQAKISRSNLIVWSVTAPSFRAMPRTCKCGVLSPFRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP77</accession>
    <name>A0A401GP77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0510290</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614883.1">
        <property type="nucleotide sequence ID" value="XM_027759082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP77"/>
    <dbReference type="STRING" id="139825.A0A401GP77"/>
    <dbReference type="GeneID" id="38780887"/>
    <dbReference type="InParanoid" id="A0A401GP77"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE83970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="10962" checksum="68080BE5BBB8B877" modified="2019-05-08" version="1">MASGFSFNGGTPRCFAFWQEFSKCYAQTDAPSQCRLQADDYLECLHHTNEIARAKAIKAEFVRKATHQAQEGRKQADILADGVIVGVGLIQRGQGEAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPX9</accession>
    <name>A0A401GPX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative peroxiredoxin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0601870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer; disulfide-linked, upon oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615122.1">
        <property type="nucleotide sequence ID" value="XM_027759321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPX9"/>
    <dbReference type="STRING" id="139825.A0A401GPX9"/>
    <dbReference type="GeneID" id="38781126"/>
    <dbReference type="InParanoid" id="A0A401GPX9"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="10">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="171" mass="18435" checksum="D229571927A6A149" modified="2019-05-08" version="1">MAPTVKVNDVVPSGTFTYVPYTLELDAHTACGIPIQLSTNEWKGKKVVIFSVPGAFTPTCHVNHLPPYLEKYDQFKAKGVDVLAVVAANDAFVMSGWARFQELKDKILALSDADAAWSKSLGLTVDLSSRGLGVRTARYAIILDDLVIKYVEVEPGTDVTVSGADAVLAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQT8</accession>
    <name>A0A401GQT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0605080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615442.1">
        <property type="nucleotide sequence ID" value="XM_027759641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQT8"/>
    <dbReference type="STRING" id="139825.A0A401GQT8"/>
    <dbReference type="GeneID" id="38781446"/>
    <dbReference type="InParanoid" id="A0A401GQT8"/>
    <dbReference type="OrthoDB" id="107110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="940" mass="106313" checksum="42CC1322AD7D478B" modified="2019-05-08" version="1">MSLNRAESLSFTSSSSRSDKSTASDTLELVDDPYTRQQHKDFDAEVLKVSKRRGIETELVENNAFSAAALLHTIMNPCKQEIIREAADINFLEDLCQNGKLRIELSKALKDMDFSKIRLNNQESFVEPPVEQISVFILSRCKVKQATMAAWYSPYIGNAHVALLDAIKEMNRTRGDQGYANYVPIIQSSGTGKSRVVDQLASLVFTVPFNVREENVESGHPFPHPDDAIRAHLLDVCSNSPKESEWFKLDVVAAYVKFFEQLFIVVREHLDQRMPHYRKKYKSSRELAAAWREYLNPQQDSVEVNGQREVLYSDVVSRLEKREPAGIGKNLKDHAQNAIQQGQALVETVNRLTNRQPERHDLRIVLYFDEAHSLSDAYIGETNRYDALCSALNQLRTLPIFCITLSTNSNLTKFSPPQKRHHSARVVEGLSDPLQPPYTELPFDCLPEGKPILGTKEKTLAEVADIGFMAMFGRPLWSAQLRGGVEKKWLLELARMKLMGMEKYTEDIDQSKRGLLAALSTRLLLDFEPTREVSRSMEAQLVEANMRIAYSVPKHREYVRSGCPSEPILAEAAAQAMNELKRTVPEQLADFVVDGLIGKGEKGELVMRLLLVQAYDKAAKKTCERDQVDLSFSRSVHLFDFLEALFGPKNLKILKQSCPDNDSRGKKFEDAFKHAQVRFTHFARNGDESSSTSYGAYAAVVRGMAIQCSTNQDVIDCIVPVVLQDDKLCEEIMSGILIQVRNKERREVIVVDEATIRHGKGFFPKGRRVDDRPYITISMQLGVQTKASKTALSQTPNASADKGRKGVLSTPSRFTVQGRSPHHKRGVHPRYPISVIGYSKKVFDMVDNKHHYAVLLGGRDLLDEHPRQADVYLTFVRRLKPYWKVGSHCYDWIDEKELNPARVQEEEVPDEETFLVGEDAVEEQTGMIGEDALEENDPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR01</accession>
    <name>A0A401GR01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0605690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615503.1">
        <property type="nucleotide sequence ID" value="XM_027759702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR01"/>
    <dbReference type="STRING" id="139825.A0A401GR01"/>
    <dbReference type="GeneID" id="38781507"/>
    <dbReference type="InParanoid" id="A0A401GR01"/>
    <dbReference type="OrthoDB" id="3270417at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="185"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="354" mass="39316" checksum="D4C35EAE4A18EBF2" modified="2019-05-08" version="1">MVIATNSTITALIVPASGMATIIEELLEGLLVEVFVAIFLYGIATAQVYFYWMNFANDSVWIRSTVLLVWVLETVHTCMCVKMITQYTIVDFGDVPAVAHIIWSAGVTVMLAVLIAAMVQTFFIHRIWILSRRSKLITAIPAVLLFVRVAFGLATASLLYRLPTWSEFRSNVGPLFTLTCGISLAAFVDLIIAVGSIYYLWHSRTGFERTDHIIRSLITYLVSTGALTVAVSFSIVLTFVFLKNSLLFAGLVEVQSKLYANSFMATLNARKLRSRGEHSAQEYNSNSIELGPSRRQGTQTDHKTMKPIEIFQHTTNISDNTGGVVDERNSVAQLKVVRSSIELGETYQKPQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSE2</accession>
    <name>A0A401GSE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prolyl aminopeptidase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0702990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616026.1">
        <property type="nucleotide sequence ID" value="XM_027760225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSE2"/>
    <dbReference type="STRING" id="139825.A0A401GSE2"/>
    <dbReference type="GeneID" id="38782030"/>
    <dbReference type="InParanoid" id="A0A401GSE2"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="61"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="329" mass="36799" checksum="EAF50A63F060320D" modified="2019-05-08" version="1">MIKITCNRAPNYSSILYGSISSAIDSASTIEGTLERDVPGAGKLCTTWYKVYGDLKSGVTPLVALHGGPGIPHDYLISLADLTALYAIPLVLYDQLGCGNSTHLPEKSGDGAFWTEDLFLAELDALLKHLEIQDNYDLLGHSWGGMFGARHAVRQPKGLRRLIISDTPAAAKLWVESVSVLLKTLPKETQETLLKHEAAGTYDAPEYKEAVFAFYKKYMCRLETWPEALTAAFGLMEEDPTVYMTMWGSSEFHVKGTLKGWSILDELHKISVQTLLLNARYDEAQDVCVQPFFKGISKVKWYTFAESGHMPHWDEREHYVEVVAEFLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU74</accession>
    <name>A0A401GU74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0802940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616685.1">
        <property type="nucleotide sequence ID" value="XM_027760884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU74"/>
    <dbReference type="STRING" id="139825.A0A401GU74"/>
    <dbReference type="GeneID" id="38782689"/>
    <dbReference type="InParanoid" id="A0A401GU74"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052527">
        <property type="entry name" value="Metal_cation-efflux_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847:SF1">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="287" mass="32179" checksum="D431818520EA8519" modified="2019-05-08" version="1">MQELRSALNYPSAKVKVGQALAFTDLRRVDTARTIHKQWGRVADHDHIPSVVPPSIPLLASNALLTYTALTPPNPPPKSSELSKYEEPDVISRGRFNWLLRYCTRPMALAKALAEVAVIVAKQYPSTLSDSVLSLLLPSSTGSGVQTTKMFLAGWVFICAGGLLRLWCYRALGRFFTYQLSVKHEHQLITVGPYAIVRHPSYTGMIMLAIGNFLWANESGSWWANFGSFGTVLRGTCIAIWATYWTVVAPLVVSRLGKEDRILKKEFGNQWEEWSRSTPYKLVPFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUP3</accession>
    <name>A0A401GUP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Docosahexaenoic acid omega-hydroxylase CYP4F3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0804750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616864.1">
        <property type="nucleotide sequence ID" value="XM_027761063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUP3"/>
    <dbReference type="STRING" id="139825.A0A401GUP3"/>
    <dbReference type="GeneID" id="38782868"/>
    <dbReference type="InParanoid" id="A0A401GUP3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="582" mass="65169" checksum="B6B3780A941B6F7F" modified="2019-05-08" version="1">MIVTIYHLPQRHLSQPNFALVPVSSVVFGWAKHLYKLGGRSSKTITPSDYLQRLSQYLVLVTMSPLDNLLGPPSNSFWFGHLSRFMTRHGWEFQMDVAQNYGPVVNLKGFLGQPILYVYDPKALHNIIVKDHYIYEEPPAFLTSNHLNFGPSLLSTVGDVHRKQRKMLNPVFSIAHMRHMLPIFYKVVGNLSAAMGSRVTDGPQELDMLGWMGRTALELIGQGGLGYSFDPLVRDAADEYGNALKEFLPVLFSLDLLLPSLPYLVRIGSPAFRRRVVNMIPSRRVQRMKAIIDTMYRRSQEIFNAKKAALAAGDKAVTQQVGEGKDIMSILIRANMDAKLDEDKLSEEELLAQMSTLTFAATDTTSNTLARILGLLAEHTEVQERLRHEILTASRGVQPLTYDELMGLPYLDAVCRETMRVHPPVTILSRQARKDIILPFSQPIRGKNGQLMSEILVPNGTQIFLGITGSNLNKALWGEDALEWKPKRWLSPLPDAVTDAHIPGVYSHLMSFLGGGRACIGFKFSEMELKVVLTTLLPKFTFELSGKPIVWNMAGVRYPTVGKENSKPEMPLKVGLYKTPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUR7</accession>
    <name>A0A401GUR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0804540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616843.1">
        <property type="nucleotide sequence ID" value="XM_027761042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUR7"/>
    <dbReference type="GeneID" id="38782847"/>
    <dbReference type="InParanoid" id="A0A401GUR7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="298" mass="32204" checksum="F9C11B15AD1C3AFF" modified="2019-05-08" version="1">MPAALDPVVGHQSPQTGQPQVPSASSNMSPHVAAQLSEATRMTPYAHVAGLPSHAFHHQVQTQRAQTNAHGPIMQLRHHGSHHQPQVPHYYLSPAELDASNPSFLQALRPPSPILPIHEHRAYITERLYTQMPSPNESNNTTSRMTAKEIAMWNSLGELNPSDLENVDPRRPLSPGIRTIMHAPSDLHTGAFAPLPIYEAEGGSDSSSSTFSATAAPSRAILGETQPPFAYPGTSHAHIEELHSNPRVHEGFPNDRHPPMFSLMLRAAQMGGTVMPPPPLGGGHGDTSHPHSTGKIMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUZ4</accession>
    <name>A0A401GUZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616970.1">
        <property type="nucleotide sequence ID" value="XM_027761169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUZ4"/>
    <dbReference type="STRING" id="139825.A0A401GUZ4"/>
    <dbReference type="GeneID" id="38782974"/>
    <dbReference type="InParanoid" id="A0A401GUZ4"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="262" mass="28609" checksum="264A9A078FFD5DCE" modified="2019-05-08" version="1">MSGSIRPVIVIAGIGNATGTGFATARVFSKAGYRVALIARNAGHLDKAAKVLKQEGGEAASFPVQEYSWAAITDVFQVIKAYKWPSPAKHEIRVALWNAGTGVWKPFLDITEQEVQSVIDSTIVGPWAFSHQVLSIFKQNEVDELGKRGTLLFTGATASWRGNVTTSAFAAGKFALRALSQSLNKEFGKQNIHVAHSIIDGGILTDRSAGRLTDPAALKEYRENANVRLDPESIGKAYLYLANQDNSAWTWELDLRPAHEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVD3</accession>
    <name>A0A401GVD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0900650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617100.1">
        <property type="nucleotide sequence ID" value="XM_027761299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVD3"/>
    <dbReference type="GeneID" id="38783104"/>
    <dbReference type="InParanoid" id="A0A401GVD3"/>
    <dbReference type="OrthoDB" id="6362124at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32775" checksum="0D997F9CDA6799DA" modified="2019-05-08" version="1">MFPTQAQHESWQDESPPPAFLRPVDLCSVDGCRDWADVRSDVNGMGCPVCRYHCYTNPQGIPSVSTASCTSPVWSSQVLHERHDDLRPPEPSAPVLCTKCTYSATDRLGIEDHMREKHGDMAFRCPYVLTTTGESARCEFTTDDYMGLRHHLLLSHGQLVRDYGGKSSLQDAARWRRRVAERTPIPPELSLTQPKRSRAHEKLEHRSVRRQHPYASPSQARLPGPGPPRKHLKVEPPWIPDALWSAPTTLWREPVRAAAKQPPPKSEHRGDLALFSTSLERGRSVDTSPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWA8</accession>
    <name>A0A401GWA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Start control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0903280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617362.1">
        <property type="nucleotide sequence ID" value="XM_027761561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWA8"/>
    <dbReference type="FunCoup" id="A0A401GWA8">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWA8"/>
    <dbReference type="GeneID" id="38783366"/>
    <dbReference type="InParanoid" id="A0A401GWA8"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="546"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="840" mass="90255" checksum="B4F16BE062EC250B" modified="2019-05-08" version="1">MQPAQRPPPPQQQVQPQPPPQQQPPVKIYNAVYSSVQVYECMVRGIAVMRRRTDSYVNATQILKVAGVDKGRRTKILEKEILPGKHEIVQGGYGKYQGTWIPLERGRDIAIQYGVAPLLGPLFDFVPNANPLGALPPGMPSVTGAPGGFVPSGLAPPPIMPGSALRLLNQGRAQGLFTPSTSGMDLARSSTYPSPGAYYSGAYPQSPFSPIPGVSPTPPPLMPSSLKRTRTDSDFDYAMASPANSSQISPPVLAASPDIQMAERSRPASAAPQLEGVTGPSPAKRARTEPSPLQSQVTDDALQPAPHIQLQPTPPVQDVAQQQRASTPAINGISRPPSSEAALPNGKPPSEAPPLEAELLDVRFATKPTMPHTTDTSAPLRDPRRVNVVSAICQRDDPTPVLDALREIPPDNPDLTMDVDLVLDDQGHTALHLAASLARHGIVDALLSSGADMHRGNYNGETPLIRACLATHNFDQQTFHVLVGALHASIRTIDTSRKSVLHHVVASAGVKGRAIAARYYLDHIFLWIAQHQGGDFRSLVDLQDEHGDTALNIAARVGNRSLVRTLLDVGANRILPNKLGLRPGDFGVETEELGGGLRADDILSSLRSAPSAPVQKSQDVLADMTTMVQSLGNEFAVEIKAKQDTLDVTQAHLRAATRSLSDQRKQIQLCQAQCGELDQVTQRVRNLQKALVDEDAFDWTGRTEPSGSDAAASAGPAFRAHGQAAPMATLTGSVDISFNLDVDPTVPVSDSVASLIRLRRLKLWHQRIEMLMEERLKSLQGASAEKEFQCKKIVALCTGVSIDKIEEMLDGLVVAVESEAQVIDIGRVSGFMQKVRNGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX73</accession>
    <name>A0A401GX73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1000490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617720.1">
        <property type="nucleotide sequence ID" value="XM_027761919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX73"/>
    <dbReference type="STRING" id="139825.A0A401GX73"/>
    <dbReference type="GeneID" id="38783724"/>
    <dbReference type="InParanoid" id="A0A401GX73"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="268" mass="30734" checksum="496B7A2362529E4B" modified="2019-05-08" version="1">MPYCARCARSFKNNQALWQHEENSGMHNVCRECEVDFGSESELISHYEDEHYYCDSCEELFDSESELEDHNEEAHWYCRSCERFFKDENSLNYHLRSSIHRPRAYACPGRKCTKAFTSHAALVNHWESGACPSGVTRESVNRVAAKLDKTGLITNPTRLLGGPSGRGESVVTQVWATERSWNGEEYECFLCHRGFRSLLALNAHLQSPVHADKGYRCPKTWRGCGKEFKTLSALCQHVESEQCGVRRFSKEMQNVIESMSSKMKKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY07</accession>
    <name>A0A401GY07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-alpha-acetyltransferase 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1003550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618021.1">
        <property type="nucleotide sequence ID" value="XM_027762220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY07"/>
    <dbReference type="FunCoup" id="A0A401GY07">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GY07"/>
    <dbReference type="GeneID" id="38784025"/>
    <dbReference type="InParanoid" id="A0A401GY07"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000091">
        <property type="entry name" value="Peptide alpha-N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="200" mass="23076" checksum="1E8614D7998E4D49" modified="2019-05-08" version="1">MSSIVYRQYTGESDLPHIMALVQHELSEPYVIYTYRYFLHQWPHLSFLAYPDHSSDPVGVIVCKQSMHKDITNRGYIAMLSVHKNWRKRGIASTLVRRTLEVMKLNGVEEVVLETEFDNSAALSLYESLGFIKEKRLYRFYLNGKDAFRLVLVVPPPSDVDDEDDPEARTRGTKPLYILPARTVTIPPLPYDPDDEVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYJ9</accession>
    <name>A0A401GYJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1004710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ARPC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618137.1">
        <property type="nucleotide sequence ID" value="XM_027762336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYJ9"/>
    <dbReference type="FunCoup" id="A0A401GYJ9">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYJ9"/>
    <dbReference type="GeneID" id="38784141"/>
    <dbReference type="InParanoid" id="A0A401GYJ9"/>
    <dbReference type="OrthoDB" id="429520at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="138" mass="14753" checksum="D5C92094274F3846" modified="2019-05-08" version="1">MDVNFRKIDIDQYDEDVLLESELCEADPRDPTQVLNDAKQKAAAVRSSLAKGDITEALGIVLEGAPYGPNVDEAKNLTLQTLVSILNSTKATEIPGVGMALPGWGDVSGSVLLGWHEKLTEAAGTGCIVRAMTDRRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYL8</accession>
    <name>A0A401GYL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1005010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618167.1">
        <property type="nucleotide sequence ID" value="XM_027762366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYL8"/>
    <dbReference type="STRING" id="139825.A0A401GYL8"/>
    <dbReference type="GeneID" id="38784171"/>
    <dbReference type="InParanoid" id="A0A401GYL8"/>
    <dbReference type="OrthoDB" id="2789888at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="425"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="717" mass="80812" checksum="DE0EDB75BAA17A9B" modified="2019-05-08" version="1">MSDSSQFPLNIAYDILCSTMDRPTVLRIPVPIDRKWPQIAAEIARQVQLAPTFIVLYKLRTPANFEDLEQGLQIGDVEGIADRVRPLDDVPHDMTQFPPDKVHVVVVVSPPKMAAEWFSWVNLSQTALTKLLQVVIEIPNRWSRNDVTSNGGVFVDRSSVLQNIVDKLKAKRTYRANYNSPTFQNASSLAHFSQSFSPAMGPSETVKGDNEFETFYLVSWRFSNDAPLVCSDPSSSLKARSFVVYFIHSPFLSGSIQSDPLQYKEQLSWQFPMFVMRRDSWGHVRKFHPNSDFSVVLHDFRCPVVLSEVVSQKDEGESDRYRMLVEAIVAARVGKYLLKATSRKQFFVVAIYLTASLEVERYIVSEDLSAQKNLIQQEKFHLRDPSRAAEFLREMYNLKPLLEELAAELDETKRADLAKIETDTSKMLSLNSRASWTKTHPSESRLESVAEHDAPMNISDDNGVFNSRSVRSVLDKANCEIDSVGYGHPHIALVVRKDDGTSAGFLKFVKDGNPEVEILQYLSRIDSPANHTIRPIRVWPIEGGRIVSMPVGGGWITYLEDLDARLWGASQQLFEAVGFMHDHGVAHMDLKPGNIVIPPVYGELSIIDFSIAVRVKGPGHKLMGYAGTRGYTAPEVGRVAYCPIPADLWSCGKVIMGLCEKMKPSFARTWLRDVSKRLMDNDPDKRPMMAEILQAMSRVGRDRDELERQISGVVETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ26</accession>
    <name>A0A401GZ26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1100910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618328.1">
        <property type="nucleotide sequence ID" value="XM_027762527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ26"/>
    <dbReference type="STRING" id="139825.A0A401GZ26"/>
    <dbReference type="GeneID" id="38784332"/>
    <dbReference type="InParanoid" id="A0A401GZ26"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="349" mass="38535" checksum="A2AB53B30A2822F4" modified="2019-05-08" version="1">MPDSYLITGGNGLLGRQIVRLLLERGETSVAVFDVRVAPGDLDERVRVFTGDITKDHEIDQAIQDCQATCIIHTAALIGFTGHGRDLLYRVNVGGTKLVVDAAVAHGVSKLVYTSSASAVFAGKDQAGVDETVPYPEKPLDEYSDSKAQGERIVLEANGRGSLRTCALRVAGLFGPGDRVAVPGYMGALQRGRTNTQIGNNTNVFDNTYIDNAAYAHLLAADRLDPAHPKHARVAGEPFFITNGEPRRFWDVPRAFWRAAGWQEPKKFTVIPRPVAFFLASVLEFIGWLIGWKPPLTRYLVIICTTTRWCNISKAKDALDYEPLVSLDEGIKRSVEWYFESRKSTKKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ55</accession>
    <name>A0A401GZ55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1101230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618360.1">
        <property type="nucleotide sequence ID" value="XM_027762559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ55"/>
    <dbReference type="STRING" id="139825.A0A401GZ55"/>
    <dbReference type="GeneID" id="38784364"/>
    <dbReference type="InParanoid" id="A0A401GZ55"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019208076" evidence="4">
        <location>
            <begin position="21"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="5">
        <location>
            <begin position="73"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="530" mass="58280" checksum="9DFD4ED3C6771A4B" modified="2019-05-08" version="1">MAGILLLLLVPLLVFLYIRTNDRKLSSLPAEVIATSPKRWTKEEVKQTEAALVGAPPSLLSGQLLPKTGRRYIVVGGAGFLGGWIVVHLLARGEDPRRIRVLDIRAPVRKDLTEGAAKDVDFLRVDMSDAQAVDAAFTKPWPTDSRASGEPEPELTVFHTAAIIRFYERHPDLLRFSDNINVKGTQNILDAARRVGASTLVYTSSGSISVRRTRFWLWPWEMQPGYFVQAINDDDSLIPKQHDHFFSNYAVSKSRGEQLVRAAEKSPSGSGVLRTGCIRPGNGIYGPGGDILIGLYLAQKKNMTWIANIMSSFVFVENCSLSHLCYEQRLIELQRGSAHPDIGGQAFCVADAGPTTTYGEIYDALTLLTKGEVSFYHLSPTTMLALAHVVEAYYVGRHFLMQSPFAFLGRVIPPLTGDIVLLQPTLFALTNIHLLFDDSRARAPPEKGGLGYNGGITTLQGVCKVYLEHLNGGVLQRSINAHSDVDHEFNPARAEKGVEEIVKKVEKSVEKGEKLLSNGIHRAANALNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H027</accession>
    <name>A0A401H027_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LINE-1 retrotransposable element ORF2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1104520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618686.1">
        <property type="nucleotide sequence ID" value="XM_027762885.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H027"/>
    <dbReference type="GeneID" id="38784690"/>
    <dbReference type="InParanoid" id="A0A401H027"/>
    <dbReference type="OrthoDB" id="2742885at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="704"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1497" mass="169236" checksum="4B2E816A59476CFF" modified="2019-05-08" version="1">MAIHKTNSGSDAASGSQRRGAGLHSGAAGNQAPTLNLIKSTQRRAQLEDNDRFVLYNTGCMSIPAIWAELKAILNPEMYKGIISLKKISSKHSAWHIEMMVKKEVGSGLKRTISSMTRERTPKFVKATKGDLDPSVKWRSRAVSLWRIDLWRSWRDRKVNSNGKKQTSPAVNSRTARIMTLNLNGFKSKAIELEQLLCKEKIKVCAIQETLVTDRAHQLRVPGYTTYAQNWTTGFRGQAVLVHQSLSSYLVEQKEGHYIHVKISGLTRNSVPVHVIAIYLPSGGNFVRERRKRIREILAINKRVLTHTPGAPIIILGDWNMSAAQIGQEINPPITGLQVLQTRGSPLSRFPVNGAPKSLDHIVVSASGRIHLRRPRVHRDYPISDHRPVIAEFRAIALEAPSKINRMRFDTDAIKGKGRSIVNHNKWSALSVEEASDEEELNTRTNAFISTMDKVCKKLEVKRALGSHKPRFPRKLASMYKRRNTLAKKLAKMATEGKVTAEVRESYLKATKTFEMAHKKWATTEERKAVKHTLTDLRAGDLKKVWTRLMSSIEHDRNASALPLVRNAKGELCVTPEAILEAIADHYDALANADPGPSQDEDHWADVEVGGDRQPELQGLNEPLTWKQVLLSIRNMERNTSTGDDETHVNVLKEMLKEECMQKVLMDSPGMRRPELINFALGEIELPEVPYTKMGKAFLPILKSIWAQGVVPEEWKEAEVCSLYKSGDPELMANYRGISLISVGFKVLLGVMANRLSTGLEKAKLFVREQAGFRAGEEAVAQYIAVAEMVRRRHIVGKSTYAIFIDFKKAFDRVHHEALYKILDHMGVRGQFLTLIKAMYRTSRIHVSAGGHRTRTFGMARGTRQGCPLSPILFIIFVNNLLRETTCGGITVPGLSVANKCPGGKYADDVVGLEETDEKAQRFCNNVREWGVKWGMEMGLAKCGVMLITGDEELDERHRQNVYDTPEGPLPIVDEYKYLGITMQKSVGDSRGKDGNELAFVKLQAAKGEKVLNVIRPLLRDPKWPMSIKATVIRTILMSKMLYGSEWVGYKLAHAVPIQRIVNKALKLAMGSSSKSRQYDCYSLGYELGLPSIAEEQNALRARLSAKLQYSDGIKTWLKELSQHPYRAAKKTWITTNQKYEKELLRGLTKHDGEPLRPWVARGRAYELHTRCNDYRNEALDQLRNTRNEVDNRGFEVEDEPAGVTRTVAGYRPTRYDSSLERQLQQTMLMGIRTKTPDEWQHISDMKDCMLERNMTAQRSPAWQFYDKFGIGATRGYLRNALSRPDLNKGVNWLIRVRTRSFPRVNDRWQVLSRTGAPPFERDHCPLCGDKVIHGWEWEHLVMSCDHIEVGKARAKYLKKSIELLKDQLQLAPYVRPDDEDDFFQDRVQYEDDISLTRAIGIYIVGGVHINNFDVDYHRGFGQLDELPEGLDSFGYTFIAEFLAEVAPIWVGSLFPEGDPYYSVQDEFASLYSPKGDSLGELTPQTVWSNVSAFLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0E2</accession>
    <name>A0A401H0E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1201060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618794.1">
        <property type="nucleotide sequence ID" value="XM_027762993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0E2"/>
    <dbReference type="GeneID" id="38784798"/>
    <dbReference type="InParanoid" id="A0A401H0E2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="73" mass="7837" checksum="D9D0EE9EB19E0388" modified="2019-05-08" version="1">MGELDSGQCWPPGASAKIATRRDSRLTAMFSLPGARLVIHMPSVESGVLRSRIAQIAMVLARYLGVEPSIPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0N1</accession>
    <name>A0A401H0N1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1201780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618865.1">
        <property type="nucleotide sequence ID" value="XM_027763064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0N1"/>
    <dbReference type="GeneID" id="38784869"/>
    <dbReference type="InParanoid" id="A0A401H0N1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="154" mass="16750" checksum="DC1ADAD287CC45D5" modified="2019-05-08" version="1">MLSSSIRSSVSLLGDPATLSQGGRTDSQRQNLYPYPIGPKGHRLLAIRLPHPPAAPLVYPVLWQRAQCDIPPFAVDDVDGVQCLPSDDRTDGGRHYPRSRESTDLHLPVVGISIRSGGAINPEHSTIVQDPRQLAEMPDPEGPKMSVGRSRFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H170</accession>
    <name>A0A401H170_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1203730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619056.1">
        <property type="nucleotide sequence ID" value="XM_027763255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H170"/>
    <dbReference type="STRING" id="139825.A0A401H170"/>
    <dbReference type="GeneID" id="38785060"/>
    <dbReference type="InParanoid" id="A0A401H170"/>
    <dbReference type="OrthoDB" id="2801117at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="152"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="39224" checksum="06F83164D3881448" modified="2019-05-08" version="1">MSKLPRELPEDLQCHSEQFPHLNSAYQICLRLEEEIEADASPAQNSKEQMIFCRILGYLLCYGPNIGARVAVYKQIISCKDKKALVQLGKMYFDHYVRAFRSNKGPTPTPSNHASRPSLDTMADMIKDCLEEAPQGHSTAKNKALVRDGFRCVVTGAYDFISVMRSEELAGRARSEGVNLTYTECAHILSESTNLNTANSDKVWSIMNTFSSRKNLSDDLNGAKIHRLENVMTLEPSVHRSFDALEIWFIVTKTKNKYKLEGRSDLYLRQLPNDVTFTTIDPELLPVPSPDYLALHAACAKVAHLSGAAEYINKVLRDLEEMPVLSEDGSSARLLEDALLHASSRSPVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1N3</accession>
    <name>A0A401H1N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619215.1">
        <property type="nucleotide sequence ID" value="XM_027763414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1N3"/>
    <dbReference type="GeneID" id="38785219"/>
    <dbReference type="InParanoid" id="A0A401H1N3"/>
    <dbReference type="OrthoDB" id="3267821at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="318" mass="35249" checksum="56176F16C14007EA" modified="2019-05-08" version="1">MSESINPLYDVPSSPPPPSPRNSPDPPILPLLPADQPNSDTVFEWLSPTPRQSLTPATGNSSPSGASAHKRPAEDMTQFAEATAHNVKLCPDNCRALLDFSKVRPQNTASHYVDHPLHELNAAEQLITLSATLMKILECQNELVPAEAVYNISENITKYIDTETTTILAHPDLVAYVHDDAPVIILEAQLKAKNKWNLSELKDDRVKWEVIIKYSRTKFNNKRHTIKKALGDSLGGRGPNAKPAQDIIDLCIATNTQLNGGKLAKAAKPRAPTVAMLERVTFLSFWEYVDNELSTVRTFHKDDAKKISKMFAQILEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1N7</accession>
    <name>A0A401H1N7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General alpha-glucoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1301710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619269.1">
        <property type="nucleotide sequence ID" value="XM_027763468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1N7"/>
    <dbReference type="STRING" id="139825.A0A401H1N7"/>
    <dbReference type="GeneID" id="38785273"/>
    <dbReference type="InParanoid" id="A0A401H1N7"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF51">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE88356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="536" mass="58529" checksum="F513F9135528FFCD" modified="2019-05-08" version="1">MSSAAVLEKAEGDPSRFEDAASFEKGKQYGNLTALAQAAATERALTPLQAIRTYWRAFFWSIFMCMGALLWGYDSQVGGGLLSVPSFRRDFGYEADGGWVLAARWQSAFNSISSIGGMFGGLSLGYISDKFGRRGAVVLCCLVSITGIFIQFFTPPHKNGMLLAGKLINGYALGMYVSGASAYSAEVSPLALRGITTASVNLWIDLGQFMSNGVIEGTGNFSSAYAYRLPFALQWIFPAILLAGLPFAPESPWWLVRKGRVEDARKVIIRLAGDSTDIDLQLHQICETIELEETYAANSTYMDCFRGVNLRRTVIASMVFVLQQAAGVVFVLGFSTYFFELAGFADSKAFQLGVGVTALGVVGNLLTFYTVNRYGRRFIFNWTMLACTVVLFLIGFLSIPTSQGAKWAMSIFTLVYNFIYQTGIGPLGYVIFAEVSSAKLRSKTIGLGILTNSMCGMVANIVIPYLVNPDEANLGGKVGFIFGGLAAFGTIWAWFYIPETKGLTVDQIDTLFERGISPRHFQSINLEEEEVPEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Z2</accession>
    <name>A0A401H1Z2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1302490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GBE88434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000287166">
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        <location>
            <begin position="229"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
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        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
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        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
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        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
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        <location>
            <begin position="690"/>
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        </location>
    </feature>
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        <location>
            <begin position="705"/>
            <end position="731"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="91845" checksum="EEBAB9BBF56108BE" modified="2019-05-08" version="1">MTTTASSPTLADRNEIHKSCKNLEVVVNILNDYCEAANAIVLLQKKLAKAIRETAGSKCVAEIPANALNTSATVFETLAEVDVKFAKSADKECDAISAEVKKWFKKLAKEERAHDDRLANANAKIKQAGQLFEKKSKRNPQDAAGEHTRYMNLLGTLGPEVNQEKYNHALLVTQRHSSTMYSLAACLSRVADSEWLRSCEGVRKFSPTVGRLGEWRALCEGGWSGAVPADLPDADAQNYGQQNTSEGDRRVGQELAVPSSGIPAPEYSSRQTSGAATPLGHSPRAPPQYLPESGGPTSNPPTDALRELQDAKSRALGKNKNDTLTSITSLSSFPSPPTHFPLPPVTRRDSDAVLITTTPETKADPQSESRTSSGLTPFPRMTDSPTAESPSENFDGSLAPPDMSTTTQIALSSSAPANRLENAVEEPMTLTTETTNITTEHSPLQPPSPLPRNADVGKPRSGDRSVPGDLSGSYKTRDYVGDAEFGVHPTRVVTKEEAKASNREISSPKNLERSDTSKSNGSTVAALRDRYVRTAGATSPRWKEVPRFSGSVSNLAVRYESPGAVPPSPRSGAGSSSDERRHMSLDSTGRVSDVSLPERSGATGRYVPTDAALPVSDINLRRQRIEELEELELREKEYELRMQEREIEHRAQELELQRVLLVNARRPDGYTSDSSRGTATRFAPRPLPDSPSSAPALQPRYPMYSYSTTHLVPQSSNPASASHYGSSQPSSPVYRPTDHSTSCGCEACSVSKYRSADPSPTLRSLRPPAPPITLRPEKPKGWIRRLSMPVISNISAFSLDSKKNISSAGIAGGPGSRNSYALPDEDGRLQSDLRAGIRNRSSTNLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2J7</accession>
    <name>A0A401H2J7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ORF">SCP_1400810</name>
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    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619589.1">
        <property type="nucleotide sequence ID" value="XM_027763788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2J7"/>
    <dbReference type="GeneID" id="38785593"/>
    <dbReference type="InParanoid" id="A0A401H2J7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="69" mass="7521" checksum="131F2FA637A315FE" modified="2019-05-08" version="1">MSTIPNIYLDSGAHLVGNPQELEATNFLGLSKDTVLDSNTWKAKKAIDAGESHLHMTTTLRSAVAILRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2N1</accession>
    <name>A0A401H2N1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1400920</name>
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        <name type="scientific">Sparassis crispa</name>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    <dbReference type="InParanoid" id="A0A401H2N1"/>
    <dbReference type="OrthoDB" id="2749813at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8160" checksum="030E7632C0721F92" modified="2019-05-08" version="1">MSSRARSRPLAITTVVGTVATLGYMYVAGTQSKRDRAHDSIFKDSFKQAGNLKPGDSDVRMGSSAVRTAMHGNKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3H1</accession>
    <name>A0A401H3H1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1403080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027764012.1"/>
    </dbReference>
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    <dbReference type="STRING" id="139825.A0A401H3H1"/>
    <dbReference type="GeneID" id="38785817"/>
    <dbReference type="InParanoid" id="A0A401H3H1"/>
    <dbReference type="OrthoDB" id="3268553at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="3">
        <location>
            <begin position="234"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="445" mass="48989" checksum="750616C20F8B5B7C" modified="2019-05-08" version="1">MNLSADEHEAIVAQVQITKLQKKLTNANKQLAKQKKALAVAQAPTEDDFERIPAEEEEPASDAEMGINLISSFRKGPAVTIPIQKAKLTRRPQVTLQHLRRQGSVHAVATPPTQALQDPNRHSTQSDSLATVTNTPLDQDDTSSMRNHPPSQPMVLDSSDPENIDVCATPTPRTTTHKWHCPMGGSNSLSASTQDCPKSSAARSGSSHAPVTKALKAAEFINNESPSGRPKASQYTDDIISHKSNARGDLINEIRKHIAAAYGFVPGDKPAAQRKNVKLYQGLIHESTFHYKDFDLDVGSRSGFLRNTIVTKLIKECFFKNKNSVGIKFRKYFDPIRTPTLALLLTGVEHCIKEWSTGIHAQVAFSEFENKPWYLNHMEDITKWARSSPGVVCNLCKKWHDHARRATGVADDDAPTGHLSAAAIEDAQKELQGHTGEMDSEAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4K0</accession>
    <name>A0A401H4K0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1503170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620222.1">
        <property type="nucleotide sequence ID" value="XM_027764421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4K0"/>
    <dbReference type="GeneID" id="38786226"/>
    <dbReference type="InParanoid" id="A0A401H4K0"/>
    <dbReference type="OrthoDB" id="3248529at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="191" mass="20669" checksum="16A4575B6537D2DC" modified="2019-05-08" version="1">MPQTRAAARQQQAPISSPAPIEGPAQERSSSAPAPSPFRIKIPARRARTPPPASSPLPAVPPRPRKRVRREPVAEPPLPEALSPFAAFNSDEDIPWMTQASANASSPTRPTLSHRSRESSPIQANNALSTPSTVRSSRAAVRALLSNVCSSHVLKYPRLVRLPILPTLHCPSQPLALSCRLHLYSCFYASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4T1</accession>
    <name>A0A401H4T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1600840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620335.1">
        <property type="nucleotide sequence ID" value="XM_027764534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4T1"/>
    <dbReference type="STRING" id="139825.A0A401H4T1"/>
    <dbReference type="GeneID" id="38786339"/>
    <dbReference type="InParanoid" id="A0A401H4T1"/>
    <dbReference type="OrthoDB" id="2442602at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="193" mass="21666" checksum="DACEC1AE70435C28" modified="2019-05-08" version="1">MEPSASQPVRPEPTRNNSAGKAPRVGDKEKTEDKNGASKASIASAHRGARYKEKFQALREKFDQVTATHDQYQRELAIADEKVKRLQEECNLLLDAVDIAVPAQPSLLHYLSRDPIPPQYHSYTAVPTSRDTQTHSSPSSIESIRNQFHRATEGGVMPPSPIMPDIGPLCAENDIPEDIRRMHYHFQHHAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5F6</accession>
    <name>A0A401H5F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620590.1">
        <property type="nucleotide sequence ID" value="XM_027764789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5F6"/>
    <dbReference type="GeneID" id="38786594"/>
    <dbReference type="InParanoid" id="A0A401H5F6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="14531" checksum="4B4A6E3FC2BEB408" modified="2019-05-08" version="1">MACHRASTGTHVRRPCPLEPRRPGPLERRRLYTTHRRLRPRDPATQRGTRSNDGPARTSAVPVPSNLAIPVPSNFAISVPMNAATSVPSNASSNSPRTPPSLSPPTSRSPHNVPWSSSARPSHTPATRSNSVRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5J0</accession>
    <name>A0A401H5J0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1603170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620566.1">
        <property type="nucleotide sequence ID" value="XM_027764765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5J0"/>
    <dbReference type="STRING" id="139825.A0A401H5J0"/>
    <dbReference type="GeneID" id="38786570"/>
    <dbReference type="InParanoid" id="A0A401H5J0"/>
    <dbReference type="OrthoDB" id="3265188at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="172" mass="19072" checksum="7BBBC96A9EA18A14" modified="2019-05-08" version="1">MNPHVSCLSEEDIGSMDPKSTVASSISCADLYIDVQQHPGLDAFTDPAQGDDRSAHDFILNIYDERTRNRAERGLGMNVACATEACARQHRSFYFSVALSGSRARLIRWDRAGMIVSESVDLHHDAQPICEFLWRYAHASQSQRGHDPTVQPAMKVSDLLRPTTTARLPGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6G3</accession>
    <name>A0A401H6G3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620876.1">
        <property type="nucleotide sequence ID" value="XM_027765075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6G3"/>
    <dbReference type="GeneID" id="38786880"/>
    <dbReference type="InParanoid" id="A0A401H6G3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="55" mass="5516" checksum="67355D940FABFD82" modified="2019-05-08" version="1">MADELRAVRVALGSPVLIGVGHGCSALGVLGSVGISGRLLMRGLSGPSYAVHGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6N1</accession>
    <name>A0A401H6N1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1801320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621021.1">
        <property type="nucleotide sequence ID" value="XM_027765220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6N1"/>
    <dbReference type="STRING" id="139825.A0A401H6N1"/>
    <dbReference type="GeneID" id="38787025"/>
    <dbReference type="InParanoid" id="A0A401H6N1"/>
    <dbReference type="OrthoDB" id="2538110at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="13313" checksum="367D73FE844BC57C" modified="2019-05-08" version="1">MSPTTEKKVRRDTPDDVKGRPEPTNDVHVLSERLSRDPRFNPPTPSVWKRVALLIFVVVLFWLAFSMRAQHHKPAVVHAQRYSKEFKYRPAASPVITERLKDGRTRIRGAMPSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6Z0</accession>
    <name>A0A401H6Z0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1900670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621131.1">
        <property type="nucleotide sequence ID" value="XM_027765330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6Z0"/>
    <dbReference type="FunCoup" id="A0A401H6Z0">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H6Z0"/>
    <dbReference type="GeneID" id="38787135"/>
    <dbReference type="InParanoid" id="A0A401H6Z0"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="427"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="955"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="631"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE90218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1047" mass="115095" checksum="CF6A711A4ED2987F" modified="2019-05-08" version="1">MTAQPVAAAPAWKFSFFDAAPVKDVHDLGSSPEIFRKAPEISAVISTTVGSLVADIHGSVYQLNRDFETTRSWLAHTGGRVTHMAERKSILITLGEEDSARHPFLKVWDLENADKTGAPTLLRSTKVQSGNRPHPVSTIALSAALSFLAIGLGDGTVLLYRHLDQSIFSGSTSLTSLPKPRVIHESPAEPITGLGFKEPDEDNPNVYLFIVTTNHVLTYQASGKGSGSAPAVVDEVGCGLGCATMDWRAKNMVVARDEAIYVCGIEGRGACYAYEGSKSLVHTHLNYMVIVTPPFVPTASAASGTVRDFVAKSSAGSVPKADITKVTIFDLENHFVAYSGTFTEGVRAVISAWKKIYVLSNDGKLSCLEEIPTSAKLDMLYRKSLYHLALNLAETQHLDQASVADIHRQFGDHLYTKGDYDGAMQQFVKTIGNVQPSYVIRKFLDAQRIHNLVTYLQELHALGLANSDHTTLLLNTYTKLKDVSRLDSFIKREARRASDGGKDELPFDLDTAIRVCRQAGYFEHASYLAKKYERHEDYLRIQIEDAGNYKDALMYLRRLGTEAAEANLARYGRAMLDSLPEETTQLLMDICTSLAPLSIEAEEQQSPATRQPSAAAPSYLSYLAINRGAPSASSETAVPSSASMTTVRPGDPIPPSRRDSLHDVSRVSTPPPGTPTTATPAKARATSVKRPSPKLYFAHFVDHRDHFVRFLETVALRRWGQSTDAPEVAVEADPDADEQAEKRDQTAVWNTLLELYLEQADANAEAESGGGKVLSVLQSTVPYDPTHALILCSTRSFTPGLVLLWERMGMHEDVLRFWMERAREGAPGASAEVVHRLDTYGEARPQLYALVLRFLTSTQELLAAHSADVQRILRHVDEAHIMHPLGVVQVLSRNGVTSVGLVKQWLIERITQGRDEVQMDQQLISSYRSETQAKLKQVEELSDPDRPRVFHVTQCSACGGQLDLPSVHFMCNHSYHQRCLPEQDTECPNCARAHALVREIRRNNARLAGQHELFLSEVREGGFASLAAGFARGSMNVAALDDVDALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H715</accession>
    <name>A0A401H715_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1900280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621092.1">
        <property type="nucleotide sequence ID" value="XM_027765291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H715"/>
    <dbReference type="GeneID" id="38787096"/>
    <dbReference type="InParanoid" id="A0A401H715"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="90" mass="9907" checksum="F63508E68C88EC00" modified="2019-05-08" version="1">MKGKRLTSFTGKLFNMYECAALCTLKVHDLYCTPTLLQILHTVSSTSCIDSLRLDKDYNAAETVGGTGEDMKPSDIEDELTTIAMLVAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4U5</accession>
    <name>A0A401G4U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608098.1">
        <property type="nucleotide sequence ID" value="XM_027752297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4U5"/>
    <dbReference type="GeneID" id="38774102"/>
    <dbReference type="InParanoid" id="A0A401G4U5"/>
    <dbReference type="OrthoDB" id="2919381at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="281" mass="31127" checksum="AA0F4C063537116B" modified="2019-05-08" version="1">MPPPLRHMPPGPPPRSGAPGPPTGPTSGPLAGYVPRPPVGPAPAPVKSRAQRAYEHLDNDESESELSTTDGDNEPDVAEVQQLNKQRQRNRGPTNLPRQGALRSNDKGKTVPQPSDTDNDVSPAPHNWPDTFPLPRIIDAAHGGDDGTCTQATNLIRQMQQDERLTASHGMMNLLISWRRHSSSGVIHPPMVPPPRRMTNPTSLSTFDEWVAWYAQNPRQVHWAIRHLNNDRSEAPLHQDLEVMWLARRMAPIIPLGVPATARNVFIEHTAELFSIPRLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4X7</accession>
    <name>A0A401G4X7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608128.1">
        <property type="nucleotide sequence ID" value="XM_027752327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4X7"/>
    <dbReference type="STRING" id="139825.A0A401G4X7"/>
    <dbReference type="GeneID" id="38774132"/>
    <dbReference type="InParanoid" id="A0A401G4X7"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="697" mass="77546" checksum="4BEF53B8435E2235" modified="2019-05-08" version="1">MAKNSTRPIRLRAAPKSEHSLEPAGEPPGGLPVDQLPPQTRRKRRTQDDINTQEAAGGASMENNPPPAKCIRHASDTVVGSADKHAVDDVPQSTRRTRQHPAAELVSAPTVEENPQPQKQTRRVTKPPVKVAARDAAQVPTPPKCKRCTAAEVQAEKDAKAAAKKEREDGEAEARRRIAQVEDDLVRAGNKIERERVTRPTSQRQGLSELPSEDETADDRSSLTEYTESGLTDNEQPKKRARKKGVRADIVNARQTPSTAAAASTSTIDEQKSQYLQIQTAQFASDDEAVERFDALSSPEKGRDKRLMNASLVEVDKVDPDETPRPLRRTSAKQVLVKTEDGSQPEFHMESTVKPSIQAVGASRQQVKTVRTTENVYTTIVKVEESEQEGNLDPKTKPAKGKKKNVDLPMGAKAGQRWLHVFLPTLMKYMGTLDNPWVIGDAELVDALQIIWNTVYPRLEYEVRPDNDCAVFNVAGQRIYDWRCGFGSTAAAVVELYLQKHQYDTEAKRRDAAIDLVQNMRFAYDDAEGDDYQTFKGLFRGELVARTLIYHYQKMKGAINVPTLYGEDGDRREVGAVGISAAAVERILVFWQTGAIRLVNGRPFILKTQNPTTGVESTWATQFSADNYGKNTADFVQSAVDSLSEKKFVKLMSKVEQYTKPSSWSLGLHHDLIEISDDEDLNVNHRKRLIDAEVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Y5</accession>
    <name>A0A401G4Y5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0100810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608122.1">
        <property type="nucleotide sequence ID" value="XM_027752321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Y5"/>
    <dbReference type="STRING" id="139825.A0A401G4Y5"/>
    <dbReference type="GeneID" id="38774126"/>
    <dbReference type="InParanoid" id="A0A401G4Y5"/>
    <dbReference type="OrthoDB" id="10012223at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="307" mass="34588" checksum="76C3AB06B436395B" modified="2019-05-08" version="1">MATTPTLPGDFGEDVTVPRPFTHNVPDNLRRANVRLQFPPAYVVVGVYRLFTDKKLYGPAWKKCEHGAVRGLTIGLVWATTTFKMQRKFVEIFLINSPRVTGLSKESVFGFGVPFDLPTYATVMFLSSQITVILTWCLSHNLRIARERAYNQTIESRGKGSEFWQPYVEEWDVPPHVGGSGWGKFFGGGLGKIVVKIGLYPFDFVPLVGILVSAWLRALGTARYLHRPYFQAKGMTTTQVSVFIEERKWDYRAFGFAAALLERLPLVGLVFSISNRIGAAMWAHDLEKRQHYVAELKISKNGQVAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G558</accession>
    <name>A0A401G558_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0101630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608203.1">
        <property type="nucleotide sequence ID" value="XM_027752402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G558"/>
    <dbReference type="GeneID" id="38774207"/>
    <dbReference type="InParanoid" id="A0A401G558"/>
    <dbReference type="OrthoDB" id="3215905at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="344" mass="38554" checksum="120240036A075E70" modified="2019-05-08" version="1">MALYFAEGGDSDKVLGLTCHHVLFKTDGATNDDYVFAGAGAPRKFVQLLGTPAFDKLLGAVKTRIAGHAIMVEFYERQIKRLEARVGGDDEDNVAKAKELRKTRDLLDEANEAIEDLEKFYEKVKKEWGKPNQRTIGYIRSSPAIAFNVGPEGFTEDWGAFELDGPKFKEAFKGNFIDLGTEISPGHFTLKMYPRDDGKATFEYPYDRLLPLRDMITEERMREPDMLDHDNEACLFVIKNGNATDITIGRATGIFSFVRDDDTAQESMEWAIYNYDNKSDVFSAPGDSGSIIVDGLGRIGGLLTGGTGKTETSDVTYATPMWWLWPRIKQHFPNAHLDLQPAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5E3</accession>
    <name>A0A401G5E3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0102470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608287.1">
        <property type="nucleotide sequence ID" value="XM_027752486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5E3"/>
    <dbReference type="STRING" id="139825.A0A401G5E3"/>
    <dbReference type="GeneID" id="38774291"/>
    <dbReference type="InParanoid" id="A0A401G5E3"/>
    <dbReference type="OrthoDB" id="5371837at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019054175" evidence="2">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="323" mass="36400" checksum="F133DD0A3D3CBFBE" modified="2019-05-08" version="1">MRSSTFLAMVTVVATPVLVGAVPTPADGSEALSFGDGLKIGKDVLGNFQSGNNNKNQQHSRDYEELLARDFDDIMARAEPAPTHAVHEHVHQHAHKHHAHKHQENLKHHYDQKDVPGHAHQAEHTAEHFVTHPTSEHAVVSPAHLVREPSPYRLASSHAGVRPRDIEEREPSPYRPASSHAGVRPRDIEKREPSPYRPASSHAGVRPRNIEEREPSPYRPASSHAGVRPRNIEEREPSPYRPASSHAGVRPRNIEEREPSPYRPASSHAAVRPRNIEEREPSPYRSASSHAGVRPRNIEERELKDRDWYNDIFARSTNLDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5H8</accession>
    <name>A0A401G5H8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0103000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="8">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608338.1">
        <property type="nucleotide sequence ID" value="XM_027752537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5H8"/>
    <dbReference type="STRING" id="139825.A0A401G5H8"/>
    <dbReference type="GeneID" id="38774342"/>
    <dbReference type="InParanoid" id="A0A401G5H8"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="10">
        <location>
            <begin position="74"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE77425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="513" mass="58534" checksum="53A826EE4B4690D2" modified="2019-05-08" version="1">MSNEIIPNGAAPPINEPTKTKGMPNRMSLKLSHLPSKKDIKPVYPRTPSSIDPNNPPWPAFRGYHTYSFAYATMGHRLPTILGKAIDDVIETLNQESAEDRIVDLLKCIERMDELKDELNAHAKLRPIVDDGEADVALWNKEIAKYFQGKDFMNAPWLFAEAYKYRRLRECFSVSKYWTSYDVFFRQKCDTFARSNEAVFELSMRFAEPFKHKEGMSPAEQLEAVRLMFMELTQICLWGNSTDLSLLINMTEEQIKSLQSTGGENLAATEKNILGNDMARLWEVVRDLKGKTGGRVDFILDNAGFELYCDCVYADFLIQSGLVNQVRFHGKRYPWFVSDVTKKDWEWLLNSMVYGHLFPKATDQEKASLHRLGLRWKQYEKEGKWVYEQHPFWCTGYTYWDLHSEAPDLFLHLSRSDLVIFKGDLNHRKLTYDCAAPPSTDFEVAIGPMASASGAPKVCSMRTIKSDVVVGLGKDGDALAERLDKAEPGWKISGKYAIVLVSEGRPGEKVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G729</accession>
    <name>A0A401G729_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0108630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608894.1">
        <property type="nucleotide sequence ID" value="XM_027753093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G729"/>
    <dbReference type="GeneID" id="38774898"/>
    <dbReference type="InParanoid" id="A0A401G729"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="55181" checksum="73F6F1EC30BA5A13" modified="2019-05-08" version="1">MRAHIRLWNQPMTHIIMSRSTLLSAIEHSTASALVLTTTMIVDKSSDGVDPQQPLAGPSRSAGLQPPSFEESMRDQALPSYSDQFPESSEVYVPQGGEAPPPEFTPYEAEYFVSGGAGDIVSHDRHLNEDGEALYRFLLSHSQTPPTLVLHVHGDHTESRTRWVSRRDNDGNHRTEPEYYTEEVVDFDFSIDVGQHIAAGPVHWSLPDNEPAYRGKMYKEVDDHLSLQLEGDMLLGLTRRHSTRRETKLAKASQAERASKGLPPWATLQLGSNRNDSSNLPIGAQQAQVLKSSRTLRQWADEYCASDKLLKEFTYEKTVCGWNFANLETAVNAAIKSTYFSGRVTVEFKLTNAQIHVRPDNGLSRTLSNKWLKVLLCVLLIFPFIWLYRRFGRRGGGRWEVCGGAYFLKSWQPVDPDAPPPPFPGDGRTVHTQAGNARLVGMREGVWFQRWEGTIRRAVTGRLISTTPLKEPDDGPLHAAFILDGYPAVMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Y1</accession>
    <name>A0A401G7Y1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0111360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609166.1">
        <property type="nucleotide sequence ID" value="XM_027753365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Y1"/>
    <dbReference type="STRING" id="139825.A0A401G7Y1"/>
    <dbReference type="GeneID" id="38775170"/>
    <dbReference type="InParanoid" id="A0A401G7Y1"/>
    <dbReference type="OrthoDB" id="3194584at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="585" mass="65042" checksum="85C90A7B04D6B85D" modified="2019-05-08" version="1">MNPNFAPQNTGGNTADHAQLSSLLSMYAQLAGTNNPYAAAPQIPFLPHAQLSNNPYQGFPQYNQNLPQQPNQSFTLQGMPQLGQNVPGRQANQGIQASQSAPQQFSQADLQHLLNQPFFASNIGQAGLGQQASAINLTLMHLVQSALQMNVAVGTFPDDEQRLIQALHDGGIKKQTKRLALEALHGVNNHPAMAWKDYYLEHVDRLDQAAANLQHPVKPETVEKSSTSQSSSSNTGRQIETQVSASLPRLTDQDEHHKGHPYTSASTRETNTYRAHGERHDRRVIKSKRSSDKPATTVRRHVEDVVSLHPTHNNLRIPELPSRTPSPPLSETAPRKGKRFMEEDKDFFIKFIQRKLSKNPYLKQAKLCALLAEKAPYHSAASWSSYWLRHHDLPDKILAAARKKAVAQNKGLPEHSSSGNNECGSDSGLLSAGESDVHQGITGTKRPTESDYDTEDDLRNMGHSGDQFLSADLRVLARHVASQPNWDFMTRTEQWKPFAAKHSRRSLEAYAQAYGRFKTEIDRWVRKFRRGAKKAKAGPSSQPGPSKQTPEIQEVSPSAIYSRKRRASTSASVEAIEKRLKTDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Q1</accession>
    <name>A0A401G9Q1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0200920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609808.1">
        <property type="nucleotide sequence ID" value="XM_027754007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Q1"/>
    <dbReference type="STRING" id="139825.A0A401G9Q1"/>
    <dbReference type="GeneID" id="38775812"/>
    <dbReference type="InParanoid" id="A0A401G9Q1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="180"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="530"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="705" mass="77529" checksum="3277860B93BEA7A0" modified="2019-05-08" version="1">MPGLATFPPFPENVPTHALLVVDFLLLKAGDAAEIDKLWKAATGLGFWYLKNHGADEEVNGMFDMGAETMALPLEEKMQFEQGDDGTSPGYKAAGANVTDETGALDSVEFINISKDDALAWPGKVHRSYPRTVNTRMEPTIAPFVRKALDVNLTIIDILEAKLGLQEGALAKRHSIDERSGSEARCIKSPPRPHGFSEDKAALGSHTDFGSLSFLHNRLGGLQVMVPGATQWQYPIPGHAICNIGDALTILSGGILMSNLHRVVPPPKEQGKFERWSVVFFTRPGNSIELRALAEESPIIAEAVAQAPAGKYQPGSTAKEWFARRVRNERRNNRTVFAGLYQRGTPSSITMPGLITIPPFPENVPMHPLLVVDYEKIKAGDEEEIDKLWKAATELGFWYLKNHGVEEEVNGMFDMGAETLSLPMEEKMKYEQGDEGMSCGYKAVGANATDDTGAPDAAEFINVAKDDALAWPAQVHRDYPATVYACMESTVVPFVHKSLEVNYTLVDVLNGRLGLPEGTLASKHKLEEHSASETRCIKTPPRQHGMTEDKAALGAHTDFGSLSFLHNRLGGLQVMVPGTTEWQYIKPIPGHAICNLGDAMTIFSGGILRSNLHRVVPAPKEQGIYERWSVVFFFRPGFSVELRALADESPLIAQAVAQAPEGKYSPGVTSKEWFTRRTKNQRMKNRKGPETYRASRGMEHQPYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA95</accession>
    <name>A0A401GA95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0202890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610005.1">
        <property type="nucleotide sequence ID" value="XM_027754204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA95"/>
    <dbReference type="GeneID" id="38776009"/>
    <dbReference type="InParanoid" id="A0A401GA95"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25144" checksum="061A7F7319AD7201" modified="2019-05-08" version="1">MSIPASPTLVNGVPSRAQTPFICASSPSPSIELSHASDEQEFAIRLVSAIRVPVDFTDILVALRNRPQDRQAVVSMQRALEMVEWMQTARQELIAAEERTSRARTRVDQVWSLMRSMVTRTAQEIWREHGDEDIGHILGYTTNGIPASTPRSSPEPIPVRPRPPRSHIPSGRSPLSQPSFSTTSTSSRRSHPYRDKCIPKQGSRTSRRTCYRCGGDHYVRDCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAM6</accession>
    <name>A0A401GAM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Developmental regulator flbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0204060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610122.1">
        <property type="nucleotide sequence ID" value="XM_027754321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAM6"/>
    <dbReference type="FunCoup" id="A0A401GAM6">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAM6"/>
    <dbReference type="GeneID" id="38776126"/>
    <dbReference type="InParanoid" id="A0A401GAM6"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="221"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="403"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="639" mass="70837" checksum="11B5BF8FC023B1F3" modified="2019-05-08" version="1">MAPEVSPATSSHMMKTTKRGRPFLKDTLDLFATLVVSLQLGDNKQFFRTFHNSFTTDDAARNLASLKFSQSNRGPDPREPARIVTTTTTTTFSMTRDMAKAMCQQFMDARLIENAADPGSNLFKERGVYVLTPKGLHVLERFMSKNGINGDHLQHVFASQPICMKLLHLERRSVDDEIIVSHSVITSLFRRFVGRQPNYPPEFLDSLDAFQKYHERSKGVALSDVPERPPNGKTAVVHRNCFPAVSALEWLCDFTSVIGREEAAEMAAQFVRFGLIILVSDKRKNNDSAIIFTVRGAAGGGNSSISQHGEFRCTAKAIYKITDEGRRMARWDNDGSENSPNTSASNINSAVRSSDDHPGDTTATDTAASKDAKIHRRISMTEKLNATYEADKKGNQKESNTDRLRYIIDEPQLRSLFREFLRTNFCEENLAFYLEVQDFKRKFNITSSAIASNSSSAAPRGGPKVTPGQIAMERHHESLIASAFSIYNNYLAPSSPSELNIDHGLRNELSGYLSEVITSLTGKAFQGRVELDQATQFNATQLQTMIRLYERIQTHVFRLMATDSVPKFIKTPRFLALRIKLSDEDETGLSDFPLLPTNSSTPVVPPGLGGDEVGGAYVTVSQRAAAQPSVTDRPAAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAS5</accession>
    <name>A0A401GAS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0204630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610178.1">
        <property type="nucleotide sequence ID" value="XM_027754377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAS5"/>
    <dbReference type="STRING" id="139825.A0A401GAS5"/>
    <dbReference type="GeneID" id="38776182"/>
    <dbReference type="InParanoid" id="A0A401GAS5"/>
    <dbReference type="OrthoDB" id="4087970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="148" mass="16091" checksum="CDFB4DDAB451CBA6" modified="2019-05-08" version="1">MAKSARSKIKRHFRAKKRTEGIYAAVEAARLNRLALKLKAISTADDEGERMQQDPAQAQGGGEGEGEWEDMPDDQQADDAAAGPDAMALDSGSSTDAAKLISTHGPRGSRHEEWRASKGMAPRSQSRGINRQGGVKARRKAGRPQRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAV9</accession>
    <name>A0A401GAV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610200.1">
        <property type="nucleotide sequence ID" value="XM_027754399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAV9"/>
    <dbReference type="GeneID" id="38776204"/>
    <dbReference type="InParanoid" id="A0A401GAV9"/>
    <dbReference type="OrthoDB" id="3269047at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="559" mass="59136" checksum="CCBB1119E5CC0BC9" modified="2019-05-08" version="1">MTALASQKQSTQQVVKSKKESAENPKPPPVPESKPHNQSQVKKMSRRSSKPIITWFQRKWSGTVRARRASETDSIRAQRLGARSPNAKEKQRRSSVPLPPILTAPRLKSKGAGSSKRNTISLNTFDDQASNTDGHAADSDDGQRSSLARDSTWSPISNYEADEDASVRPLPPSSPPSPSPSQSTSSYLSDPRTFRSMTASTKPTTVLSLDLTGGMAHIAQAPPTPTIPGHRLPLHIRTHSTGPGSGGSITFSAIPPSSPTTPSRPSSGGSVPRGAHLSLQAPQHTTHHPRNNPRPSSPPQDDASVLTLASSAFAMPSARYAAALALSGRASLADDSISHFSHAAGHGDSTSHFLLGEMDDERERYQDPDQDVDASVRALRPRSSRRGSWESEASGWSASASLALTGTAGGQSQGGTRSLWTAGSYRTGGVSVYNEDREDEEPSEDNHTHENGKYSSEDTSTSLSPSVAAENTSSTATSSSKAEDLRTPPVTVPESDAEADSPMAPSFESQVDGSLTSHRSVMETPKLASVPLEGSVVESSLLTTPAGETGDTTTTAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB43</accession>
    <name>A0A401GB43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0205830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610298.1">
        <property type="nucleotide sequence ID" value="XM_027754497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB43"/>
    <dbReference type="FunCoup" id="A0A401GB43">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB43"/>
    <dbReference type="GeneID" id="38776302"/>
    <dbReference type="InParanoid" id="A0A401GB43"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="282" mass="30176" checksum="9F1077178470E6D7" modified="2019-05-08" version="1">MSGRLQHKVALITGAGSGIGLESSVLFAQEGANVALVDINLEAVKKTKTLLDGRFPNVKAIAIKADVGKESEVKNMVDETVKAFGRLDVMFNNAGIMHPADDNALNTEERIWDLTMQINVKGVWWGCKYAILAMRQNPVDAAMGLHTGGSIINTASFVAIMGAATPQLAYTASKGAVLAMTRELAMVHAREGIRVNSICPGPLKTPLLMDFLNTQEKKDRRLVHLPMGRFGEAVEVAKGALFLASDDSSYMTGTDFKVDGGLTSCYVTPTAEQVLPPPSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB44</accession>
    <name>A0A401GB44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6741 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610295.1">
        <property type="nucleotide sequence ID" value="XM_027754494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB44"/>
    <dbReference type="STRING" id="139825.A0A401GB44"/>
    <dbReference type="GeneID" id="38776299"/>
    <dbReference type="InParanoid" id="A0A401GB44"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046629">
        <property type="entry name" value="DUF6741"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20526">
        <property type="entry name" value="DUF6741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6741" evidence="1">
        <location>
            <begin position="8"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="136" mass="15553" checksum="937EB006ADBE7691" modified="2019-05-08" version="1">MSRHGRIPLDSYHRNSSTLIKFKRKGSAHSGVTLGEAMANVMLSGNNSLTHYDLNADHRGKIILRLRWTGYGSMTYELPVDDYDGYVELQTLARRIARACVHYLQANMIPIPWDQVILYHMEEVSFGVWQPVLSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBE6</accession>
    <name>A0A401GBE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0207000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610413.1">
        <property type="nucleotide sequence ID" value="XM_027754612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBE6"/>
    <dbReference type="STRING" id="139825.A0A401GBE6"/>
    <dbReference type="GeneID" id="38776417"/>
    <dbReference type="InParanoid" id="A0A401GBE6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="843"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1159" mass="124861" checksum="2C19BA4C023749D7" modified="2019-05-08" version="1">MPLDIDPNYVLQAARLTAIVAAAPRQDDPRYPDWETRIYLEVSRLEKSFPQPLKSLRMPGIVISALLEFTRAYQQKALARLDHISNDDERIYKRYPLAVCEYGECEDLGRQWWTEDPYCKLPPVKSTPAEGWGNVPADDDTQGRGEEDLATGDLITKGKGKERADNDVGTGMVGERIVHVEAGEDKGKGKSKEKAQGKVAHAMSEEEDGGEGEGEGEEQEGEDDDDADSDEDDDADKNDDDEMAEDVPGAGQPESIEVDAASPPPPTARPISISPAAPSLRKCKVVITESSKESENEEAAPKAKRMKPIEVAKEKGEAPTTSGRVQRAQKRMVQTEVEGSKVSTKKSGKRKAKESSDEEEVPTVKPPKKKRATKEYKSKEFIESEDETLAPPSNLPAKTAGDSNDGVAKTNAPAKPVKQTMRMTATPHVAPKAKAKAKAKATAKGKAKAKVMVSQKDMWKKTSTRVSDFMWAHATDSLVPCVGCQEKEWPCKLNTANFGRCLECAARGVSCSIAPRNTDGVPLRGNSHTTQHEFQEMCAALVVEGKPLPTSPPPYDVKVDSDEPDGAEPMFMGALKRKLPKKTKTRNAAASSSKVKGGEEVEATKQKATVTPYEANAEGEASVEKSSKSKRATKSATATGAVALSNSGEVSKSGAVAKPGEGKKSGPKAKPVRSQNSGVQDGGEVTRTSVCEPDEVLPAKSVAKEGGQMTRVAMGGRSGPMVPVITRKAKASAPKAAAKMPLAEGDGMEEAARLAMEAVRAMAFQTGPAAPPQASSSKCMLTPVADEPEDAPEYQAEVAEDERASLERPHDDRRCSLLMPHETSAGAAEVAQEVTPSLEISKALKGVKSSTLAKAGHLDEGRRPAKRGAPLDRKAAKKEAEAKRDAKANRLRAVPPTSKAPHLRDIQRVSTGSPAPVNEGDTPSGEETSQSSNDDCANCAELRQEFLAHKDGMEVQFQERMADLNTVKAEITAALQRINPPSAFQENARSIREEVKLAMEEFRRPVSIELQESVKLAVADLVAKRHCLPELKEKVNRLEQGANQTVSQADVDKLQGELADLRHSMELQAARSDSMEKELRSSAAEAIAQASKLEMELALTKEDSMAVATSALDEAKKVGKEVATAREETSLVAKSLDAFREKVDSAMVFTAFRPDRHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBF5</accession>
    <name>A0A401GBF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0206630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610376.1">
        <property type="nucleotide sequence ID" value="XM_027754575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBF5"/>
    <dbReference type="GeneID" id="38776380"/>
    <dbReference type="InParanoid" id="A0A401GBF5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="87" mass="8947" checksum="E14C8207149ADCEE" modified="2019-05-08" version="1">MAAQASSGAPLASPYLPAPPPGLCVTGSRFHADRDTESSLAGDPAPASRFPAAMSPPPSGRVPEKAAACSLARDPWAERTDSLLVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCE1</accession>
    <name>A0A401GCE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA damage-inducible protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0210280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610740.1">
        <property type="nucleotide sequence ID" value="XM_027754939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCE1"/>
    <dbReference type="FunCoup" id="A0A401GCE1">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCE1"/>
    <dbReference type="GeneID" id="38776744"/>
    <dbReference type="InParanoid" id="A0A401GCE1"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14309">
        <property type="entry name" value="UBA_scDdi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="351" mass="37573" checksum="DBC914F21687240C" modified="2019-05-08" version="1">MAGCGVGDHAILLLRRKVNVAGRTAEQDAEMMRLQLLGDPVLMQQLRETNPEIAIAAQTDPARFAELLRQTRARHADAERELAQISTDPYDIEAQRRIEEAIRQQAVAENLEHALEYSPEAFGRVTMLYIPVEVNGHPVKAFVDSGAQQTIMSPECAEACGIMRLVDRRFAGIARGVGTAQILGRVHSAQLKLADLHLACSFTIMEGRDVDLLFGLDMLKAHQACIDLEKDVLRIQGREVHFLAEHELPDKARNVNDGIVDPSASQPSSSVAGPSGAAEPIHFPGAGNTLGSPPTDAGAGRGRGAPVPQTQSTHSEEAISTLMSLGASREMAISSLDAAGGNLDVAASLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD38</accession>
    <name>A0A401GD38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0213020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611012.1">
        <property type="nucleotide sequence ID" value="XM_027755211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD38"/>
    <dbReference type="STRING" id="139825.A0A401GD38"/>
    <dbReference type="GeneID" id="38777016"/>
    <dbReference type="InParanoid" id="A0A401GD38"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="139" mass="15651" checksum="C2AB2201D41AE099" modified="2019-05-08" version="1">MIARLNFIGNAIDLGSIEVDELTAWMYPHPANPSSFEYPGDRLLRFHETISDQEMFRPNPKNKDYDNDPVIMVLKNGNSSNLTIGRLNTIRAFLHEYFKGKPGKMSKEVGVFPRNSKSGPFSERGDSGSMVIDTIGRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GD41</accession>
    <name>A0A401GD41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0212350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610946.1">
        <property type="nucleotide sequence ID" value="XM_027755145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GD41"/>
    <dbReference type="GeneID" id="38776950"/>
    <dbReference type="InParanoid" id="A0A401GD41"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="64" mass="6543" checksum="B816038F4483B6F8" modified="2019-05-08" version="1">MHGIKDLAVCAAGRSPEDVVATRVAAPKAVINGTALLPEDTCAQWAVVVSWLTVATAAAVPRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDH0</accession>
    <name>A0A401GDH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0213910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611094.1">
        <property type="nucleotide sequence ID" value="XM_027755293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDH0"/>
    <dbReference type="FunCoup" id="A0A401GDH0">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GDH0"/>
    <dbReference type="GeneID" id="38777098"/>
    <dbReference type="InParanoid" id="A0A401GDH0"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="109"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE80181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="305" mass="34727" checksum="68F5FF40A3E85EBF" modified="2019-05-08" version="1">MGSDLDRQIEQLNRCEPISEEEVKRLCIKAREILIEEANVQVIDSPVTICGDIHGQFWDMVELFKVGGSCPDTNYLFMGDFVDRGFYSVETFLLLLALKVRYPERITLIRGNHESRQITQVYGFYEECQRKYGSSNVWRWCCEVFDYLALGAIVDGRVFCVHGGLSPNLQTIDQIRAIDRKQEVPHDGPMCDLLWSDPDDINGWGLSPRGAGFLFGADITKMFAHHNAIDLIARAHQLAMEGYKLMFDKTIVTVWSAPNYCYRCGNVASILELDEHLGQEYKVFSHAPSDVKSIPAKRPPADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDN7</accession>
    <name>A0A401GDN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0214960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611190.1">
        <property type="nucleotide sequence ID" value="XM_027755389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDN7"/>
    <dbReference type="STRING" id="139825.A0A401GDN7"/>
    <dbReference type="GeneID" id="38777194"/>
    <dbReference type="InParanoid" id="A0A401GDN7"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="20083" checksum="3915E82AA92B6875" modified="2019-05-08" version="1">MKFPAASISYCRNCERILSPPTTWAIVRPESQELLAICLRKLKGLNKVRLTEAHFIWTEPHSKRLRVSLTIQKEVLTSTILEQVFEIEYLVQHGQCPDCTKLAAKNTWKALVQVRQKVPHKRTFLFLEQLILKHGAQKDTISVKEVRDGIDFFYSQRSHAIKMVEFLGGVVPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDS1</accession>
    <name>A0A401GDS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0214800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611176.1">
        <property type="nucleotide sequence ID" value="XM_027755375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDS1"/>
    <dbReference type="GeneID" id="38777180"/>
    <dbReference type="InParanoid" id="A0A401GDS1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="211" mass="23777" checksum="091B32151ADD3ABD" modified="2019-05-08" version="1">MQSRGSQTFYDTFLFCLPPHLTYARTLIVAPTRVLIKFSIRWNEVGVHHLAILKDVGAHAGKLACLQAEVDDLENQILIVEQTSIDVDPPLFDDSASTSARQLSDTFPAEYLPHLQSPLPDAASESDAESESESESESESEPKQVQTLDDFVASFDPEDKHIQAQLLDLLRALSDLYLRTQILRSEASRKLRKLVDERNPCRSAGLRRMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE28</accession>
    <name>A0A401GE28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611351.1">
        <property type="nucleotide sequence ID" value="XM_027755550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE28"/>
    <dbReference type="GeneID" id="38777355"/>
    <dbReference type="InParanoid" id="A0A401GE28"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="113" mass="12901" checksum="3AE8CEB399216C1C" modified="2019-05-08" version="1">MSKAPRGGYNSADFWPFPTLVGLEINQRANFPHRVLRRSVEVRGSRKPNRPSDVSRSPNSLREIHVRTHTKISKKNLQWFGKRLHAFTWSSLEGVAEADMNSVKIHVIPTQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE87</accession>
    <name>A0A401GE87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611364.1">
        <property type="nucleotide sequence ID" value="XM_027755563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE87"/>
    <dbReference type="GeneID" id="38777368"/>
    <dbReference type="InParanoid" id="A0A401GE87"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019005131" evidence="1">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="84" mass="8605" checksum="077134E0C297AA3C" modified="2019-05-08" version="1">MMFPSTLSLAAVLAACSVAFASPAGASTTTVTFIKSINTVAYDTTTTVTATSYATSTVPRTTTFTSTTTTTTVTPTTTTTYVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GET1</accession>
    <name>A0A401GET1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OsmC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0303520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OsmC/Ohr family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611548.1">
        <property type="nucleotide sequence ID" value="XM_027755747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GET1"/>
    <dbReference type="GeneID" id="38777552"/>
    <dbReference type="InParanoid" id="A0A401GET1"/>
    <dbReference type="OrthoDB" id="60422at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019953">
        <property type="entry name" value="OHR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03561">
        <property type="entry name" value="organ_hyd_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33797:SF2">
        <property type="entry name" value="ORGANIC HYDROPEROXIDE RESISTANCE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="OsmC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="166" mass="17604" checksum="8FACACF98E0F9E1B" modified="2019-05-08" version="1">MLSTTLGITGRAAPRVTRAVFQPARTLMTLKNHKYTAHATARGQGRNGEVESDDDDGLKLRLAMPQSLGGKGDGQNPEQLFAMGYSACFLGALQMVASKMGKSDMAKNAAIHTEVHLGQPNDMGGFGLEVGIKVEGADEELIKAGHEACPYSRALKYGVVVNVSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF37</accession>
    <name>A0A401GF37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0305120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611705.1">
        <property type="nucleotide sequence ID" value="XM_027755904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF37"/>
    <dbReference type="STRING" id="139825.A0A401GF37"/>
    <dbReference type="GeneID" id="38777709"/>
    <dbReference type="InParanoid" id="A0A401GF37"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17413" checksum="CF9F7E030284006C" modified="2019-05-08" version="1">MAISTIFTKWQHRPAYGLRERTHRCLTEALEYLLRLVSPSLLSAQNDAKSTALHWAALNSHLPCAKALVNFPSGPGTDLIDIKNSAGRSPLGEAENVGWDEGAKWFVEVMNLDEGGRRKEELQTAENPSDIEVEIQDAEGQIAKMKIGQISTAGDAVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFS9</accession>
    <name>A0A401GFS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0307450</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611935.1">
        <property type="nucleotide sequence ID" value="XM_027756134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFS9"/>
    <dbReference type="FunCoup" id="A0A401GFS9">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GFS9"/>
    <dbReference type="GeneID" id="38777939"/>
    <dbReference type="InParanoid" id="A0A401GFS9"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cux N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="11">
        <location>
            <begin position="437"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="250"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="525"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE81022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="693" mass="78781" checksum="2418CDB014686A5D" modified="2019-05-08" version="1">MASAEYNFSGALSTWKDINLSELQKTLDAQGVELVENQRESVVGRKALADRTKEFKKTSDDEKLNVFKGLLKAYQTEIDSLTKRSKSAENAFLNVYKVLAEAPDPYPLLEAAIDQTVKVAEARELETELQRVREENAELRRRINEFVPLETAKKKADARVEQLEQRMEDLIRDKVTQKENELNATYDEKMRNYEEREQDHQRQVALTKSQLRELRMSHESSQAKLLDQSQRQDQEVVTKLAELDMVVIDLEHANSRVATVERRNELLRAEIEGMKSGNERSDQLKELESKVSDLETETDRLSQALEAQKVATKAAQATAAKKAEEAAKELRKKSNDVDQLKQKLRQYDDYDEIKRELDVMKYVEFGGLEEDDDFDGTASGNGDALGLHLPDPNAEKANAQRGKSLEVLLATKNKRILEELTKFRILHGELEASLRSTQADLAFTESELEKQRVLNERLENDLLHMDQRKTSGEANGKRIPADSLADGSGTADALAGLDLGAQKPIYPYARTAPTLFAPSADTSILPIVTSQRDRFRQRNAELEEELRKQFNIISDLRAEIKSLQADNLKLYEKVRYMQSYREDTAARPSTLDPMPSTAAGRADDMGKYRARYEEAMNPFQAFRGREATRAYESLNVLERGVLVLTRAILGNRRTRTFFICYAIVLHLLVMVTTYQCTMSSDSHLQRQPGPYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGA6</accession>
    <name>A0A401GGA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0309260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612112.1">
        <property type="nucleotide sequence ID" value="XM_027756311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGA6"/>
    <dbReference type="FunCoup" id="A0A401GGA6">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGA6"/>
    <dbReference type="GeneID" id="38778116"/>
    <dbReference type="InParanoid" id="A0A401GGA6"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE81199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="404" mass="44474" checksum="F988410912039072" modified="2019-05-08" version="1">MQTPLILPYVQWKSWRERIRNFTPAWHAVIMGTGVVSALLHNFPYGSDREPLRVAAASFFLLNLVLFVFVCACTVARYFVFPQTWPLMLAHPSQSLFLGCFPMGVTTLINAGLNLHQDWGFGGNGFLYFLWGCWWLDSAISYLTAFGMLYVMSVRQEHSTTNMAAVWLLPFVTLVVASSTGGLLANALRSHSTTLALLTVGIDFVMVSTGLSFALMIITVYLLRLILHGIPDRSLILSAFIIIGPLGQGGYSLLVNGQSLSELLPLHNFGNFPEAPLAGQILFASCFCGAYVLWSMGVAWILVACSSVFYVVQRGAVPFSLGYWGLVFPNGVFALLSVELGVILNSPFFHAFGTLWSVVAFALWLFIFLRSVPSFIDGSMFLAPCLKNNTIAMISVDEESKVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGC1</accession>
    <name>A0A401GGC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0309020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612088.1">
        <property type="nucleotide sequence ID" value="XM_027756287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGC1"/>
    <dbReference type="GeneID" id="38778092"/>
    <dbReference type="InParanoid" id="A0A401GGC1"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="216" mass="24096" checksum="951504E6C1D55273" modified="2019-05-08" version="1">MRKTSYVVAFFAVIGTLVLNVISIQRPDWLVVNNPEVLRSKTTVRYGLTQRCERQVIIIPGLPDGSKLAYTDYKCRPFPNRVTDRCEKEEKAFCMTWSTASYLSVLGAGFAVVSCLAILFGVSTHSRRRRIWRAVAGLTALHVAFQIAAFSVVTYLYSNSRFPTFERARPGPAYILNILSWIFGIIVTIGILTTGISASKGHRWAAGNRAYQPIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGF4</accession>
    <name>A0A401GGF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0309280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612114.1">
        <property type="nucleotide sequence ID" value="XM_027756313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGF4"/>
    <dbReference type="FunCoup" id="A0A401GGF4">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGF4"/>
    <dbReference type="GeneID" id="38778118"/>
    <dbReference type="InParanoid" id="A0A401GGF4"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019241750" evidence="6">
        <location>
            <begin position="19"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="108"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="139"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="418" mass="44617" checksum="004B22BC2C984B67" modified="2019-05-08" version="1">MSSKASFIALALAIVTSASPVVQDTGTRIPIHKRNTLTKEDGTFDHESAIQQSIRTHNKHRQNLINLERNEGLSAFNEGAEIQPFREYPHHEKRQKEPLIDESNDLDWAGLISIGTPGQTFTIDFDTGSSDLWVPSSNCTSTVCSTKNKYNAALSTTSVHKSGTFSIGYADGSTVSGPVFTDTVTVAGIKATGQYFSPVTTLSNSFSSNPIDGILGMAYPSISSLRQSPFFNTAKSQGSVTTGVFGFKLAQVGSELYLGGTDTSLYSGTPEYHTVTGSGFWQISGAKILLGTKAIVSNFQTIIDSGTTIMYGPPGAVQTFYKSVPGSSVYDSTYGYYQFPCTATPSVSFSWGGKSWTISAANFNLGQTHTGSTQCVGALSGQNLGLGNNVWLLGDSFMKNVYTAFSFDKAAVGFATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH36</accession>
    <name>A0A401GH36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0312260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612410.1">
        <property type="nucleotide sequence ID" value="XM_027756609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH36"/>
    <dbReference type="STRING" id="139825.A0A401GH36"/>
    <dbReference type="GeneID" id="38778414"/>
    <dbReference type="InParanoid" id="A0A401GH36"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="445" mass="48585" checksum="0A424209CD1C42BE" modified="2019-05-08" version="1">MSAEDEQAPLLGSPSANVTHGNGGGEPGPSDESIRQHVLSIRVIIYAILTAAFVVVLVSMVVFWEKVGRFAGQLPKDPNQAAQRVLDGAPIIDGHIDLPILTRERYSNNISAFDLNLRMPGHVDIPRLREGRVGGFFWSTYMPCSARPGKDFMNPTWLVRDTLEQIDVVHLLIDKYPDTFELALTSNDVKSAISRGKIAGLIGIEGGHQIGNSIAVLRQMYALGVRYMTLTHSCHNAFADSCGISKNIEPYWGGLSPLGYSLVTEMNRLGMLVDISHTSDDTAKQVLKYSKAPVIWSHSSARAVRDVPRNVPDDVLKLVGTTDGLSDAVIMVNFAPDFVAGNGEATLEALADHIDHIASITGRAHVGIGSDFDGIGTVPVGLEDVSKYPDLIAEMYRRGWNRFELAGLTGRNFLRIMEGAERVAAELHLAGFKPSVDWYNKRDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH40</accession>
    <name>A0A401GH40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="8">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0311520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612336.1">
        <property type="nucleotide sequence ID" value="XM_027756535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH40"/>
    <dbReference type="FunCoup" id="A0A401GH40">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GH40"/>
    <dbReference type="GeneID" id="38778340"/>
    <dbReference type="InParanoid" id="A0A401GH40"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000433">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000341">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="211"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE81423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="502" mass="53824" checksum="E5D0C9FE9626B360" modified="2019-05-08" version="1">MDDPAAQDPAPVSRLPPLPVAVQRNAPAQSSRSVAGLLNIRRPPGATPIPPSLQAKMAALANRGAQSSAVRSGDAATAALLGADKAAPSVLRAPALSSGLSRPVAPPLGGLAARRMKMNMPKLSPHDVPGGLHLPPIPGGGPSGAGLGPGRPIIDDEPRRLPPSNIGTPFANFAKIVDPSGALNFNGKAVLHASGVNFSNGASFAISIDQLQLDEELGKGAYGTVKKVLHKPTNVAMAMKEIRLELDQAKLNAIIMELDILHRAVAPEIVEFYGAFFIESCVYYCMEYMDAGSLDKLQGQGVPEVVLARIAGAMVRGLKFLKDDLQIIHRDVKPTNVLLNRRGEVKLCDFGVSGQLEKSLAKTNIGCQSYMAPERIQGESQNNLGTYSVSSDVWSLGLSMIEMSLGRYPYPPETYANVFAQLSAIVHGDPPELPEHFSAMSKDFVARCLHKVPNMRATYAELLNHPFLVQDRQRNVDMPRWVESAIAHRNAVRQQHQQARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GID1</accession>
    <name>A0A401GID1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ndc10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0403360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612873.1">
        <property type="nucleotide sequence ID" value="XM_027757072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GID1"/>
    <dbReference type="STRING" id="139825.A0A401GID1"/>
    <dbReference type="GeneID" id="38778877"/>
    <dbReference type="InParanoid" id="A0A401GID1"/>
    <dbReference type="OrthoDB" id="3065555at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="2">
        <location>
            <begin position="288"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="464" mass="51656" checksum="3BEF801179596775" modified="2019-05-08" version="1">MGSSRPQQFRVVSYDPPSPAVPRKRQREVAISGLAQRHSNNHATMGDGGPAVASTFVHYEMPRRSPIMLPEVPGLRTTNREGSPHPASACGAVSRPGAPRVVAGAAALATVAGSLQQSIAQLELESHDARVKKAKLDQDDKQTGSSYDHHVQNYIKYWTAFQTERRQKAPDEVPVPAFPITALKASFFLEYEMSCEKRRYGKNDTVAGSNVGKSHVSQVISALESWRRNNAYLYKEDPDAQVSLRSDIHVHTAESSTKHQEPKRIDKAQALKAMGSSGDTYTPEELKRCSIWCLTDVSGSKQIWLGLRDCAMLLLSSMMAFRGESSRILEWSDLFMSSIPMDDVRAGYRVPVLATLADNAKHNQQGRLDEHGAIRHREVELCPVGGLALLFFGFFHVLHLPLPELLPDFDDAACGEYGRRDWYGYHVFWGKQPASPMSYDNHRDRLRGIHKENEISITKVTHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIX5</accession>
    <name>A0A401GIX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucan 1,3-beta-glucosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0404330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612968.1">
        <property type="nucleotide sequence ID" value="XM_027757167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIX5"/>
    <dbReference type="STRING" id="139825.A0A401GIX5"/>
    <dbReference type="GeneID" id="38778972"/>
    <dbReference type="InParanoid" id="A0A401GIX5"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="1">
        <location>
            <begin position="436"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="791" mass="82669" checksum="BC0B5F251572B6D6" modified="2019-05-08" version="1">MHSTKPVTSPGRGQSSMRVNLPHIGQTQRDTASLPLASALGTACSTPLGGGTAAPGAPYWLQDITHQGTSPFNPDPSSYQVFRNVKDFGAVGDGVTDDTAAINNAISSGSRCGGGSCPSSTVTPAIVFFPQGTYLISTPIIAYYYTVLIGDARVPPTLLASSGFSGMAVIDADPYIANGGGAQWYTNQNNFFRSVRNFVINLTQMPASTSATGIHWQVAQATSLMNIVFEMSTASGNSHQGIWMENGSGGFMGDLVFNGGKYGMWVGNQQFTVRNVTFNNVNTSVYGIWNWGWTFQGVNINNCQVGFDLETGGTTQSTQTVGGEAIIDAVVTNTPIFVRSSVATTSLAGSLVLNNCQLTDVPTAVGIVGGAVVLAGGTTTITSWGRGNVYSGTSSSFSFEQGNIAAPSKSGTLLNSAGRIFGRVHPQYEDYAVSQFVSVKSNGAKGDGVTDDTTALQNILNEYTGCAIVFFDAGTYLITNTLTIPAGTQMVGEAWSVIMGGGSAFQNQNSPTVMVRVGESGSSGIMEISDIVFATQGPAPGAIVVEWNMNSPTQGGAAMWDSHIRLGGAAGTNLEAATCPSGSDSTSCFAAFLALHLTPSSNAYLEGTWVWLADHDLDGDGTSQLTIFSGRGILSQSAGPVWLIGTSEHHTLYQYNLAGAQNHYIGLAQTETPYYQPVPAVPTPFSINSAYDDPSFPSGLTSAWALSVSSSSDIILFGAGFYSFFQNYSQSCLTGSTCQSQLVNIDSASSISIYSLATVGVTYQLSVNGAGVIPESQNVNGLQSTVTVWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJD0</accession>
    <name>A0A401GJD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0406450</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613174.1">
        <property type="nucleotide sequence ID" value="XM_027757373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJD0"/>
    <dbReference type="STRING" id="139825.A0A401GJD0"/>
    <dbReference type="GeneID" id="38779178"/>
    <dbReference type="InParanoid" id="A0A401GJD0"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02668">
        <property type="entry name" value="Peptidase_C19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01795">
        <property type="entry name" value="Ubl_USP48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033841">
        <property type="entry name" value="Pep_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044743">
        <property type="entry name" value="Ubl_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="163"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="13">
        <location>
            <begin position="741"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1049"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="646"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1126"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="851"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1163"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE82261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1201" mass="135166" checksum="AADFFE7BC75FEDDE" modified="2019-05-08" version="1">MPPKRTRRSSPTPAGLSAGERLKRARLAGNTQYSTWGWVGTEITDASAITLEHRLATCGFLPKSSHPLCANKYAARARSTSVKEETKQPQPKAHGELEDDVIVISDDEAPSCSSKACRSTPYCLNYLGQEKWEDEGKAREAFMKVTNLGEDPVANSRDPGFPVGLKNLGATCYANAYLQVWFQDLPFRDGVYKCQPAQDAEHKFEESPIFQLQVTFAAMQEGIESAFNPVKLVESLKLRTAEQQDAQEFSKLFMAHLDTEFHKQSSPSLKSLIADQFQGKQVYGTICEKCHNSSERESDFLEIEVNIQNNATLEDRITALLQPETLSGDNKYLCPRCDSLQDAKRYTELRQLPPVLHFSLLRFVYDVSTMERKKSKYAISFPTSIDMDQFLGSAEMRKNAKNCRKNTNRYALRGVLLHKGASAYHGHYEAQVFDVQNQGWYQFNDETVTEIESLGAKPISKAKVGPAADAEKKKAAGQSQKPRIPQRKRRRVESDSDIEILDSPPPANGSKTEPEAASYISSKDAYMLVYSRIDMRSSELTKNVINGKAPHRSYSPQANGSAHAHSQITIPSPPPRAMEAVRMLNAAHDQACEEFTEKEKQAKAHFNDMRYKVMDIYRSWQLSTRDEDCVVASRQALETWISRHLAKPKKRAASPSESDETPSRSFTKSEISDEEGRNIISVSDIVCSHGQIDPDKASDMKLITRAAHHRIADDDNCLLVPDLSPLDVCETCVSEMFTERLYQIEHPRFVARFDEIAPVAENEEGYWISKQWLKDWRLAKPKMHNPSQGDPPPDAPDFKYHVKCEHDDLSTNVTARRRVSVEACLFLQDLFPTWEPLSTETEVCPVCEALIHISKEDKRELRRQAEEEKAKLKHMHDNALNGNTALLENVPCAIVPAHFVRAWRQWLLHPVEVQRPESVDNSQFLCEHGLLCLDPNSGTDLDSSVAIIKRSDWDVLEDIYSGGPLIAVENTGTKLEHELSVCEDCRRKRKSSFDMTEITVRILGPQDPTPTVETYKPDTVQTTRRPLHPSTLMTYGSRKSGGLRQSNRLRQAKDYGKRRRVTITKNMRVKDLKITFEEEFDIPIISQRLFYHGQELDDSSATVLSLGILSNDLLDLREESENIDLLSDSDTEDVPRKRRNEGQGFGGTLLGGIPDSDSDGARESSSQSDQPPATSKACSACTYENDIDVAMCAICETPFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJE2</accession>
    <name>A0A401GJE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0406720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613201.1">
        <property type="nucleotide sequence ID" value="XM_027757400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJE2"/>
    <dbReference type="STRING" id="139825.A0A401GJE2"/>
    <dbReference type="GeneID" id="38779205"/>
    <dbReference type="InParanoid" id="A0A401GJE2"/>
    <dbReference type="OrthoDB" id="3070852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12861" checksum="7DDFCB0F26992871" modified="2019-05-08" version="1">MSNDSVSEPPSSVVSFGSYADLHMSASSSTSCSSVDFGYNPFTSYGLLLGSGNQVWHLPMLPPDQSPRFIHPPMLPPDQSPCFIHPPMLLPDESSGMFLHPPMLHQDDTDTIRAQLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJS1</accession>
    <name>A0A401GJS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multiprotein-bridging factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0407860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613315.1">
        <property type="nucleotide sequence ID" value="XM_027757514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJS1"/>
    <dbReference type="FunCoup" id="A0A401GJS1">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJS1"/>
    <dbReference type="GeneID" id="38779319"/>
    <dbReference type="InParanoid" id="A0A401GJS1"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000018">
        <property type="entry name" value="Multiprotein bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="166" mass="17928" checksum="FF47825BEE969B05" modified="2019-05-08" version="1">MSDADWESKTVIGYKAKAPKVTRNTSDLNGQSVQFLSVSTEADQPIVRFCSCAVVATEKKVTAATNKAHQGTDHQRIAKLDRENEVAPPPKIAPSVGKAMQTARMDKQLSQKDVAQKINEKPSVLQDYEAGRAIPNPQILAKLERVLGVKLRGADIGKKLGGPKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK54</accession>
    <name>A0A401GK54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Docosahexaenoic acid omega-hydroxylase CYP4F3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0409130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613442.1">
        <property type="nucleotide sequence ID" value="XM_027757641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK54"/>
    <dbReference type="STRING" id="139825.A0A401GK54"/>
    <dbReference type="GeneID" id="38779446"/>
    <dbReference type="InParanoid" id="A0A401GK54"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="551" mass="61625" checksum="5548D7454903BD8E" modified="2019-05-08" version="1">MGYHPGLSCCSWRALQSVWPTGFCYAQLKNLPGTAPQSFWTGNMVPFYQREGWDFQMEVAQNYGPVVNIHGFLWEPTLYVYDPKALHSIIIKDQSNYEESSLFLQSNLLTFGPALISTLGNPHRKQRRLLGVSFSTHHLREMLPIFYEVASRLCSGIASRVDDGPKDIDMLGWMVRTSLETIGWMVRTSLETIGQGGFGYSFDSLTEDQAGEFGNALRHFVPTMFSLGIIRFAIPFVVTRGSASFRRWVLDMIPSKRVQNVKQAVDVIHKKSVEVLRSKTSALQSGDDALLQRVGEGKDLMSILLRANMIATAEHDRLSEDELLAQVSSLSFAATDTTSNTLARILHLLAQHPDVQQRLREEILESRNGGVVLSYDELMKLPYLDAVCRETLRVHPPATFWLASALKDTILPLSQPIRGTDGKMMGKLLVPKNTKIYIGVAGCNMNKALWGEDALEWKPERWLSPLPSAVSDAHMPGVYSNIMSFLGGGRGCIGFKFSVLEMKVILSTLLSHFRFALNGQPIVWNMSAVRYPAVSIESPKAEMPLKVMKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKC7</accession>
    <name>A0A401GKC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0410000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613528.1">
        <property type="nucleotide sequence ID" value="XM_027757727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKC7"/>
    <dbReference type="STRING" id="139825.A0A401GKC7"/>
    <dbReference type="GeneID" id="38779532"/>
    <dbReference type="InParanoid" id="A0A401GKC7"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="402"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="839" mass="93892" checksum="EF5AA6164C1894A1" modified="2019-05-08" version="1">MGNRTPLCYLRLAHDQHIHTCESKSHLLDHKVSSIRAVCLLVALEKHNSSSQHHRSSHNGRAERLLTLLWFRYSVVYMKAFPPDQYLEPNRYKHIYPSTQVPHLACVAPYDTLGFPDFPARIGWEVLEYKQGQEIRLHRLDQQEASTGEQISLLQEWLFFGVLGEMFGICDMSLDVSHFVHSKIVSTAPLKEFTASWAGRLGTVDRAILDARSRRMHGYLDVMDDFMFGWHPRQLSFDEAQVLHSIVMARSFCHSMFLWYLPENSSDVALYNYTPFGPSCSITLEKGAVRHLLDRGWCKSDVSMLCSAGIGETIFLITALERSATTVDHSECTDTVCNADCLDEETYVTRHVRLGCTCPHIQVDGGVVATILANGGVPRIRVPKISTSDEDIHIEVVDDGPYVAISHVWSHGLGNPRDNALPQCQLSYIAASISLLDSNKCASPSVWIDTLCIPVDPALREHRKTAITRLGKIFSEAYQVLVLDAELEKASVRCSIIEQGLRILCSDWMRRLWTLQEAVFVQNSGRDKLYFQFADGVVAHSSLDVEQNEASPHRNNIHVVHGLHGVLRALEDRIPRSFSPSQHSLEDPEPTERPIYKLARMSGSLQYRATSKAEDEPVCLASLLGLDVRSVLVHSSSAKRMRQLYLLIGTFPATIIFTTGRSALRFNDGARLQERGFRWAPASYLSHQASFQFRNVAMASVDSEGLHASYGLFTSQPRLFRECLFIGCSDGGIVYRISGSPDDDDPPPRVWLDVCASFGQVSRAALIFDDSSPDDSFRVAVVSIQGDNAGVLHATILARGWNMNYIDGEPDEHTIAKLRDASGIVNGEFTASDQRWCIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKJ5</accession>
    <name>A0A401GKJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0410710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613599.1">
        <property type="nucleotide sequence ID" value="XM_027757798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKJ5"/>
    <dbReference type="FunCoup" id="A0A401GKJ5">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GKJ5"/>
    <dbReference type="GeneID" id="38779603"/>
    <dbReference type="InParanoid" id="A0A401GKJ5"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="7">
        <location>
            <begin position="147"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="6">
        <location>
            <begin position="728"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE82686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="814" mass="89780" checksum="7ACB259DD537E994" modified="2019-05-08" version="1">MFLKPVRDASRAKGERAMLDKQVKTFPVSVREPLQTPLRDGDEKTIRRGDRIRYVIGIELAKAVTAGSPQGRSRSAFTYASLAKFGDSPKRPAAPHSLSSLFSAGSHFYDYTALSQNMATAGLGTEIVSVVNKLQDVFTAVGSSASQIDLPQICVLGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLINRQPPPHYPNGSAATKIDGDDKHANEHEWGEFLHLPGEKFYDFNKIRAEIVRDTEAKTGRNAGISPQAINLRIFSPNVLTLTLVDLPGLTKVPVGDQPRDIEKQIRDMLLKYISKPACIILAVTAANTDLANSDGLKLAREVDPEGQRTIGVLTKVDLMDQGTDVVDILAGRVIPLRLGYVPVVNRGQRDIDSNKPISAALDFEREFFENHPAYKGKAQYCGTPFLARKLNVILMAHIRATLPDIKARIAQQLSKFNAELQSLGGPLGDGSSSNVVLSVITEFCSEFRTTIDGNTNDLSVNELSGGARISFVFHELFNNGVRTIDPFDQVKDGDIRTILYNSSGSTPSLFVGTQAFEVIVKQQIKRLEDPSQKCCQLVYDELIRILGQLLAKIQAFRRYPALKDRFNHVVVNFFKTAMNPTTKLVSDLVAMQACYVNTTHPDFLNGLSAMAMVSERMNAGKPPPQDVKGGKLTAAQINNNRDLDVEAKKDDQSFFGSFFSAAKNAPKKKGVAIMDAPPANIRPQAALNERETIETEVIKLLIHSYFNIVKREMIDMVPKAISLTLVTHSKDDLQRELLQELYKPEVLDDLLKESEYVVNRRKEVIQMVQALNKAEEIVSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL74</accession>
    <name>A0A401GL74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0413030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613829.1">
        <property type="nucleotide sequence ID" value="XM_027758028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL74"/>
    <dbReference type="GeneID" id="38779833"/>
    <dbReference type="InParanoid" id="A0A401GL74"/>
    <dbReference type="OrthoDB" id="2755487at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="578" mass="65331" checksum="ED62EE75926E564B" modified="2019-05-08" version="1">MSSEQRGHDPTAHRVAHNSADYELMKRVAFRDVPPSREYIREAFRASFEQSEWPLWKLRIVPEPHQASSDTRSKTKGGPEASARFFLVGKPHFNAEGVVGRCTRGYIAVDCQDESFVFLKDVWRVDHPDMPKEGYILEDLNLHGVEHIPKVVCHGDVESQQTLTQLCWLRTIEDETNPFKTHTHYRLVFDQVYLPLSQFGDGRDLVKVIADCIEAHRQAMELAGLIHRDVSIGNMLMLPKLVKDMDDKDVVCYDGVLSDWELCKPICDETSKDGEKVRQPDRTGTWQFMSAMLLDNPYKPIEIPDELEAFFNVFLYVAVRYTPTNWLSVASFMGEYFDGIDTLSETQEYKCGRMKRAAMANGSIKRSDKLLLFVNPESSGVHPFNVIMGQILFWLKARYTLASSSMRQLGSDTVPLNTGNHNSDDQSISAAILGDDPGHGNMSKVVNLDCRDGGVDVFAQVAAALAARAAAEIEQATPIARNLETHHAMHELLMKLYNAKGIKWPKRVADRVPTDCNYERRRRGDVHAGKVIPTSQLKRRALPDQQDSMSSKRPRTETFPHPRHRPCAGSQKAAHPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM12</accession>
    <name>A0A401GM12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0503010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614166.1">
        <property type="nucleotide sequence ID" value="XM_027758365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM12"/>
    <dbReference type="GeneID" id="38780170"/>
    <dbReference type="InParanoid" id="A0A401GM12"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="64" mass="6845" checksum="7A89E170179AC9E9" modified="2019-05-08" version="1">MIATYIYAITMTCGIEIVGGTRAGTTPCLRTQIKEYHFNYTSRGAHPSTAAGLHAEKRAARGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GME5</accession>
    <name>A0A401GME5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0504260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614291.1">
        <property type="nucleotide sequence ID" value="XM_027758490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GME5"/>
    <dbReference type="STRING" id="139825.A0A401GME5"/>
    <dbReference type="GeneID" id="38780295"/>
    <dbReference type="InParanoid" id="A0A401GME5"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="61" mass="6528" checksum="C8F4179E97D544C9" modified="2019-05-08" version="1">MKEVKEAEKMGTLVEFFGTGTVAVITLVDRIGYLGEDIYIPTGPNGMSPISPPISNQLTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMZ7</accession>
    <name>A0A401GMZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0506380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614496.1">
        <property type="nucleotide sequence ID" value="XM_027758695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMZ7"/>
    <dbReference type="FunCoup" id="A0A401GMZ7">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMZ7"/>
    <dbReference type="GeneID" id="38780500"/>
    <dbReference type="InParanoid" id="A0A401GMZ7"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03053">
        <property type="entry name" value="GST_N_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="92"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="215" mass="23684" checksum="3E5FC0D64DEB4900" modified="2019-05-08" version="1">MVLKLHGSPLSACTRRAAMVLKEKNVPYELVLVDLSKGEHKAAAYTAVQPFGQVPYIVDDDGFTLYESRAIARYIAVKYAAQGEKLLPPLTDLHALAKFEQAASIELTNFEPFAHGIAAERVFKPRGGGVTDEKLVADYVASLKSKLDVYDVILSKSKYLAGDELTLADLFHVPYGPALKLAGVDVLEDPSRPNVLRWWKEISSRPSWLALKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP55</accession>
    <name>A0A401GP55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0510620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE84003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614916.1">
        <property type="nucleotide sequence ID" value="XM_027759115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP55"/>
    <dbReference type="STRING" id="139825.A0A401GP55"/>
    <dbReference type="GeneID" id="38780920"/>
    <dbReference type="InParanoid" id="A0A401GP55"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="6"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="10">
        <location>
            <begin position="164"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE84003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28707" checksum="1E5888C909AEA762" modified="2019-05-08" version="1">MFTALHPYIGSICHVYLDDIIIWSDSLEEHHQNVETILSALRAHHLYCSPKKTDLFCLELHFLGHRISHAGVEADDSKVEKILAWLIPSSASDVCSFLGLVKYISNFLPALSNRTRILNSLSTKESERDFLWSSEHQTAFNVIKQLIVSRECLTVIDHQNMADNKIFVCTDASDWCSSAVLSFGPTLETAHLVAFDSMQFKGPELNYPVHEKELLAIVHALKKWCVNLIGVPFTIYTDHCTLKNFTFQKNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP79</accession>
    <name>A0A401GP79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Wiskott-Aldrich syndrome 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0506190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614477.1">
        <property type="nucleotide sequence ID" value="XM_027758676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP79"/>
    <dbReference type="STRING" id="139825.A0A401GP79"/>
    <dbReference type="GeneID" id="38780481"/>
    <dbReference type="InParanoid" id="A0A401GP79"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="2">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="270" mass="30231" checksum="7283F63E57DA0C3B" modified="2019-05-08" version="1">MFDSSAAKPPSASSLTDSEKRHVLSLLPPESRVVAVASARVYHAPFKGRGDDWAYSGLQGLLVLGAAVHSEKKLGSNHETSFVQNYWFRLIDTASGRGVIWSHSIPVGFDYRLDKPFFHYFSGKSRMFGFRFEDDDEAEKFYRKVTSRVRTTVPPSRRKPLPPTPQNQISSAVISSPSPETCIHVAHMGYNEQGYIEATGNLPPRWKMVLKELQGHSVTKKMVDDDIEFVDGFWVGVKAVRAAAPKPEPVQTPSAQKRRKTVHRKPVQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GP95</accession>
    <name>A0A401GP95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0510280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614882.1">
        <property type="nucleotide sequence ID" value="XM_027759081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GP95"/>
    <dbReference type="STRING" id="139825.A0A401GP95"/>
    <dbReference type="GeneID" id="38780886"/>
    <dbReference type="InParanoid" id="A0A401GP95"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047154">
        <property type="entry name" value="UBL4A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46555:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="286" mass="30525" checksum="C5AF6881D5EEAAB7" modified="2019-05-08" version="1">MSEQAELAFVKSFANNLISQPIVYADDFQQPPQSSLKKIPVLPIDLPPPPERKVEESTASASISITFKCIKPPQSYTLSVQPTDTISDIKAQLAAQGGAPPADAQRLLLKGKALADGKLLKEYSVKDGDTVNLMVKPGFDWDPVRVASPLPERAAPADGETIILLPALEPSKSRMGHGRIPSVVLSPSPSLTPSPGDRTVDIPLVLDTSNIPISPASGPSNASYHAVISQPVFWDNLWHFLSTELNDANHAETAWEDFFRASKGALSASEIAKIRDSVGVTGMAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPD4</accession>
    <name>A0A401GPD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615014.1">
        <property type="nucleotide sequence ID" value="XM_027759213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPD4"/>
    <dbReference type="STRING" id="139825.A0A401GPD4"/>
    <dbReference type="GeneID" id="38781018"/>
    <dbReference type="InParanoid" id="A0A401GPD4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="58" mass="6567" checksum="576215B4C81FD3C1" modified="2019-05-08" version="1">MEWAVKIASEPVTVVAVVRLNVDWEMEGYDCTMLVLLQRTDELISHVVQVNAHTIIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPF6</accession>
    <name>A0A401GPF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615016.1">
        <property type="nucleotide sequence ID" value="XM_027759215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPF6"/>
    <dbReference type="GeneID" id="38781020"/>
    <dbReference type="InParanoid" id="A0A401GPF6"/>
    <dbReference type="OrthoDB" id="3258904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="162" mass="17957" checksum="12585A3C423BCD4D" modified="2019-05-08" version="1">MRVIDRDPTPHNLHVDLHTELRMVGPYPFFLPKTMPLFIRDVPGIVLPLTPMPSGPLDELYPSAENSCAISIHIVLIVIQGVDILSSPLSPFFIVAAFIAYSGTILIIVYAICFLSNKGVSGEFVFSDEHLLEGYEKRDSAWLLFSLSASFPSASITYEMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPI0</accession>
    <name>A0A401GPI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0601050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615040.1">
        <property type="nucleotide sequence ID" value="XM_027759239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPI0"/>
    <dbReference type="STRING" id="139825.A0A401GPI0"/>
    <dbReference type="GeneID" id="38781044"/>
    <dbReference type="InParanoid" id="A0A401GPI0"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="3">
        <location>
            <begin position="248"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE84127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="451" mass="48530" checksum="B2E62AFEC1EA15F8" modified="2019-05-08" version="1">MVVVKGAASDPQHQRGSPESKNRSRTSSLFGNAGFWIATQVFAVVSVVVYTYHYDGAGIDRKSVASISKLSLPPQSVLVDPLLFAVVGNDGRFRENSFKTHFSPTSSTPPFFQIFDPAFLSILGPAPSIRAIASNPGFAFAHEAPIWVPETDEVFFSSNDGGPLGFSDIDHNNEVAKIHLNDVFDAFAASGSTTSPVNVSATRVDLPDSVQMTNGGTGPFRSALLLISSGRGPLPPSLAIVNPSYPYNATVILDNYYGRQFNSLNDVKIHPKSGNIFFTDVTYGFLNHFRPNPLMPNHVYRFNPNTGSVRVVADGFDRPNGLAFSADGRKAYIADSGAARGFLGPNQTEPATVYVFDVERGIERFHNRRVFAYVDTGVPDGVQVDKSGNVYAACSDGVHVWNEEGMLLGKFFLGTASANIAFAGKGRLVILAETEIFLAQIAADGVDVSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPM5</accession>
    <name>A0A401GPM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0601510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615086.1">
        <property type="nucleotide sequence ID" value="XM_027759285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPM5"/>
    <dbReference type="GeneID" id="38781090"/>
    <dbReference type="InParanoid" id="A0A401GPM5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="125" mass="13542" checksum="D42B1489F521DA39" modified="2019-05-08" version="1">MKLLAAHRLHSFKRSPLECLHATFPAVRTSGRFSNAAGADARRTSVLPRAPLPPTVVPHISDPLRCRAHPHLKRLAVVPGVHFKVDSEDDPHPLRVTATGAIGVALIDYRCELLSDLVPVLAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPR1</accession>
    <name>A0A401GPR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615052.1">
        <property type="nucleotide sequence ID" value="XM_027759251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPR1"/>
    <dbReference type="GeneID" id="38781056"/>
    <dbReference type="InParanoid" id="A0A401GPR1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="330" mass="35422" checksum="A9D0215CE2DDBF23" modified="2019-05-08" version="1">MANSGSVTSSRGELERRRRGFAADPRALAHTATRRPIARINMPISTQPDSTQNEIYAPPGSAGVYTPSLTAPRESWFASPIRRVSTQHTAHCRGPTAVHRGHSRIHPRQTESSVLHEDATPITADPQHDGKDRPSTPGPTPTQRSEHTRTDRRRLSATIDQNAAVDQPNNTFRAPNRYPHPATEATPSLPNAKKRTTTNKPSAPPPHTGTRLPHTPLSNSKPRAGTGGGLIPSHPGDAVGPKFQPACAFSRGGAGSPSTEHAASTERVRRAAPGRGVHVSIPRSLIACWVAEPSSDDPGRAPNRRGADTRITTHNVHTAWAGTRRPGTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPY9</accession>
    <name>A0A401GPY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LanC-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0601970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615132.1">
        <property type="nucleotide sequence ID" value="XM_027759331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPY9"/>
    <dbReference type="GeneID" id="38781136"/>
    <dbReference type="InParanoid" id="A0A401GPY9"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="51457" checksum="FF8A8D08313342D7" modified="2019-05-08" version="1">MHPTRYISHPNQPPTDLSSAADTIHDALISNLQRLRRHPSSRPGVYLGSAGALLTDWHVAFVLPSLVLPKAYSPQTFTPGPFSPPRTGAQASFLETSVGPATLLLIQQLHEPRDTGAWKDCIRLLDGALRVALREEVDDDGCEVLYGRAGLLYALLLLRSELTGSEESSTVRDIVAQLTSDTHIRTLVDDIVQRGRFGAQEFQKELEKDERAHAPPLMWSWHGKRYLGGAHGVSGILQMLVSSPTVALAPHWVAVLGTVEWLLAIQEPLGNWPSKAGRHMARTAGGSATSRAAKRVSVEDDACDSLVQWCHGAPGVLILLASLLRRGGPVLPVSAKLREAAIAALKRGGELVYTRGLLRKGVGLCHGVAGSVYALLAVADVLDPDNDRDQAQHDAYWLERAADLALRATAYRGYEQKGEMLIPDRPYSLYEGVGGMCCAWAEVLARLRVREEGRAGGWRRGMPGYDDLRFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ51</accession>
    <name>A0A401GQ51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0603440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615278.1">
        <property type="nucleotide sequence ID" value="XM_027759477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ51"/>
    <dbReference type="SMR" id="A0A401GQ51"/>
    <dbReference type="FunCoup" id="A0A401GQ51">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQ51"/>
    <dbReference type="GeneID" id="38781282"/>
    <dbReference type="InParanoid" id="A0A401GQ51"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000034">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000006">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE84365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="149" mass="16797" checksum="A61E3F90DD6B229A" modified="2019-05-08" version="1">MADQLSEEQISEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMRDTDSEEEIKEAFKVFDKDGNGYISAAELRHVMTNLGEKLSDNEVDEMIREADVDGDGQINYDEFVKMMLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQJ6</accession>
    <name>A0A401GQJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L38-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0604750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615409.1">
        <property type="nucleotide sequence ID" value="XM_027759608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQJ6"/>
    <dbReference type="FunCoup" id="A0A401GQJ6">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQJ6"/>
    <dbReference type="GeneID" id="38781413"/>
    <dbReference type="InParanoid" id="A0A401GQJ6"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="83" mass="9466" checksum="779B23DDEC5677D6" modified="2019-05-08" version="1">MPKEVRDIKQFLDIARRKDAKEARIKKIASPVPGGKTKTKFKIRCSRYLYTLALDDPEKADKLQQSLPPGLSVSEIKKTPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRA5</accession>
    <name>A0A401GRA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615612.1">
        <property type="nucleotide sequence ID" value="XM_027759811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRA5"/>
    <dbReference type="STRING" id="139825.A0A401GRA5"/>
    <dbReference type="GeneID" id="38781616"/>
    <dbReference type="InParanoid" id="A0A401GRA5"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="502" mass="55814" checksum="65665D8E2EE1BBEC" modified="2019-05-08" version="1">MDALCDDALSGKLTAESLQRYLQPDRSIINKYGGTRNLTPLAAASLHGHLDIVELLLDNFANPNAVSANNRTPLFYVTSRKVPRDQLAIVRALLHGNAKVDECYDNDGRNTPLMNAIQQLRDKDIVHELVDRGASLTLRNSKGKTAEDLAKEYDMLQDVRPYANRKTSWAEVIDLLVAVVMFVIAVVNGGSIEDASKGVIAKLYNITGEKNKGPADDTVAKGIATLQTKEMKTTEDLQNNLTSYVSDTGLDQFFKPGDTFLQDLAKKAASLPDDPNSLYSKPDNVKRLTTLSLYQPVIYCDDSGSMDSDNRYENQRELVSRIARIATRIVPETYGVELRFINADSASNLSAAEIDAAMRRVEPDGGTMLGTSLRSKILEPLVYGVIASGKKLDRPFLICTITDGDPSRGDRPSFKDAIVECRKMLVRNGYKPNAVRFCVSQIGNDRSATAFLEQLRGDPEISDVLYCTSDRLDDRFKEFKQAENRLEEWLLKMLTEPIMNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRC7</accession>
    <name>A0A401GRC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0607810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615714.1">
        <property type="nucleotide sequence ID" value="XM_027759913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRC7"/>
    <dbReference type="GeneID" id="38781718"/>
    <dbReference type="InParanoid" id="A0A401GRC7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="143" mass="16249" checksum="7E777F242505B02E" modified="2019-05-08" version="1">MVNSRTDRADVVEVEAKVDRLTDKIKTSTPSQRNDAIPQIHSPADAGPAHYLRLDGSFYQVENYGRTHMTLDEKTVRTDSRINVNVEIPNTWREDRMSYIHEERDTGFTQIISSSGHSSNVHALTSLSMPLPCSHFALFVEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRQ7</accession>
    <name>A0A401GRQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0700880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615820.1">
        <property type="nucleotide sequence ID" value="XM_027760019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRQ7"/>
    <dbReference type="STRING" id="139825.A0A401GRQ7"/>
    <dbReference type="GeneID" id="38781824"/>
    <dbReference type="InParanoid" id="A0A401GRQ7"/>
    <dbReference type="OrthoDB" id="4708870at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="385" mass="43386" checksum="F8EEC45218FD5F91" modified="2019-05-08" version="1">MSPNVYRSLKAQLLSRIQPLYELVAVPREAPEKVDYGDIDLVVAYPRAGLTHQMVTEALRATCSVPPDGGRVTNFALAAIAFQLGDKDVSAKNGAAQVFYQVDINVMADKAEWEDQMFTSSYGDVGLILGQMTRTIGLSFGVHGLKFADPLPTRPPIAFHICNTLSPILAYFGLSMDRWAIGFSSQLEIFDWLATSTLFDPCAIVNHHEKLSTVDNSKERGRKARAMFQNFVLYARERAENKIRRQVDEVFSGSLVQEWTGVRSVPVRWVMDGVRERLTARYTKQHLDDNRGQDDIGNLDLNRELQDERERKMACIASWELVLSTMSLDDVRAEVVEVKDEMEVAGKLIYDWRAAKAEKAEKRRAVEQSMKDLNSDMTALSVKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRX9</accession>
    <name>A0A401GRX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0701860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_027760113.1"/>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="36"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="70"/>
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    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="277"/>
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            <end position="432"/>
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            <begin position="452"/>
            <end position="488"/>
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        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="375"/>
            <end position="390"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85001.1"/>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="52102" checksum="D70339BF10F1DA1C" modified="2019-05-08" version="1">MVLQIAYAALSSVLPPKYYPHAVVALVVLLVVHAFARGRTTNRDRDLHARVILVTGAFNPLGLALVTALATRGAHIIALSPHALSHPAPAVLVPLLRVSTRNEHIYAEHADLADPVSVRAFCTRFLTTPGADTRIDALVLAHEYTSLGTLLRSRNPAQREKEREAASLATFLLITLLLPALLVAPPDRDIRIVSVVNPFYAAAGPSFATSLADSSTSAPPLFLAEGRRALRTVVLTRHLQRILDSLPNRAHAASDATSPSGSNEASASGPDSARRLSQHPSNIVAVSACPGLSRKDTVEPLLGASRGVPDSSPLGAVLYALLFPLLYLLAKPPGAALQSVLHVLFLPTPFKRAQAHLAASLGADAAAAPTPSSDKSPREEKEREAPEEVLKPGALYRECAVVRLEPPVPPKEQEGEDEGKGGLPDDGELGGEALGRAVWEWYEARLKVWEKGAKTQGEAEKGREREADQQKERGEGEKQTEDKQDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSG2</accession>
    <name>A0A401GSG2_9APHY</name>
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        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Sparassis crispa</name>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
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            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="GBE85133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="Histone_H1/H5_H15"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="293"/>
            <end position="362"/>
        </location>
    </feature>
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    <evidence type="ECO:0000259" key="3">
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            <dbReference type="PROSITE" id="PS51504"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="661" mass="69757" checksum="E9240510DAB6D856" modified="2019-05-08" version="1">MAASRLSPPPATDEEALNGLKKIYLSLLPPVQIVEICLAFEPHVPLHVRDTVWPADLEAAIHALKRVPANGPSMPRASSTQSVEAEPVVGTNGSADVPSQEVHPPGEPSRDSTAETEPEASPPMASLNDPAEYRSALQTEAPRSSAEQYLRRRLSASLSPAPSPLASNDSASGTNANPGTQPQPARYSAKSPSASMVPSTPHSHAQPPATYPYMPYGYAMPSQPQHSAYPHAPYYAPPGPSHPHAYPPPYPYSPYAPPHGYHTPTPPPPPHYPGPYPRPHMPSGPADPLPAEDLPSYEEMIVEALLDSGDPKGALPKELFACMAARYPLQTNFRPSASQALQKAYRRGRLEKRPGGRYRLNAAWEGGATSRRTTRRPQTLAQTTYALHHPPQPPSSPFTSAPLAHPPQNPYSQPNGSAAQGHIASYPGYPYGYPQTGYHGYPPPPGYPRYPPPPPPGEAAAQEKTASTAATASSTSKADEEKDDAWEAAQHILSAINFGPLGSAGDGPEAGPSTSVNGPGSPPEHSAPVTAGMGFDTTAGPSTAVQRTTLTDDERASLQAQLALLAAQLAEIGDADEEDEEGEEDMQSVLISMGKGKGVATDINYFPEVFQDVRGASVGAAVAVNGSDAGAGASEEDEEDSDADMEMVEVPPFAGRDPLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTD5</accession>
    <name>A0A401GTD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0800080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027760603.1"/>
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    <dbReference type="OrthoDB" id="2554322at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="616"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="GBE85491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1294" mass="141072" checksum="3B1E02457378043F" modified="2019-05-08" version="1">MAVLPLSSAVDRAENWDEDFELQQSGQSRADAHPEMRLMDVTKSPLKDRKNTVQHCADAGPSMPIRRFSEQVENWDDDFRDNTDSPVRRLSHQRQDAQEAENWDADFEEDRHGQSPPRKGSRQDTWASSDEEDDYRFADREEDRTVTSRTRGAPLTIPDIPPVPPLPSPFPRSPTVSVFSVPPSSHGHDAYSYSSTAPLALRPTISGGSSAFALLPPSPPIHRERRRLRKKSRPTPHTNDIFELDDRAENSVPRPLPPSQPSTPEKKPSPGLPSPDDSSADHHPSTSTLLKTPLLSRIGSVGKKWSTARKKRASTGPSEVTLSEQRAHEHDAPPRPPSQLSSSPPSAKSSWFFRSGGAGPGPGSPPAHTSALKHESSMDRLLSLAGLDRVPQTPSRKRDERAAGSLPRELRSAANGNEVRSAMLFGGARRPVSMQVTNSASSSSSWGSRGSRPPVPRHASYGRSMVKRPATADSRSSSKARSVSASASASVEDLDVNEMPARISEGKKDGIQAKGKGKEKETEKHQGSRSFMGGMRRLSLVGSNKHWRSKTLMQTPDRKEPHTPSSPKVRAFPDEDQTTPRPPSRVVRRSQDALLPPLELQPAAPLRLPPSVSAPASSTIESLFHPHPFLEASRSHPALSAKFTAEPPLSSPPPSPLASPPRPKVPSSPPQSASLGRAAQPPKEQANNNSMPPRRNSLGDLKIPARISQAQVSLRRDLGMVREFAASIEQLKQLQDAYNTLVGEVHELIESSQPAPSRAISPTFFNLPQPISRMRSSTNPTPIPQYNRRELSVAFQLIETKYQIPWECVELLIDLGSGAPVATISPTPSSQSVPPMTSPAATDPKKSRERAITLAGDESKPAVPLPADTLTSPIANPPSPAQWRASTGRHDLTQRQLLLLRELLNNPDSSTYLSAEPHISEEEIDRNWRWGDAMNSTITLPSEESVQSGSGALNGKKRRLGMRKLRDILKSLKRSYSERPSPLPPVPVSSTSILASTESSLDLPREHQSDSVQRRRARTSTGPESMKSSREQHPNSPYATSVSLKHRSSPRRPSLASIFRLGQKSKSSQSTGQSSDDLKHPSSGSEHASSLRVADEEEDWDRVEAISEMNHAGRAPSDGAATVRGKTHRSPYSQHHQEPFPGGSPSVSQTSLNVQPSPHRSAPAGHFHLLPTRSPKLSNVRELAEHGTPPEPRPSSRSTNHAPTPSPSARYRPFRSRMSGPSGSVRSAPPQVLAHHGPGIILGTLPESRLSMTPENIQPLLENAREVHARCSECIIELQALLTVNGGPAQSQMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTD9</accession>
    <name>A0A401GTD9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar pre-ribosomal-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0706360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616362.1">
        <property type="nucleotide sequence ID" value="XM_027760561.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GTD9">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTD9"/>
    <dbReference type="GeneID" id="38782366"/>
    <dbReference type="InParanoid" id="A0A401GTD9"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="80"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="639"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1660"/>
            <end position="1852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE85449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2052" mass="229075" checksum="5A25F8D6B53A3F3B" modified="2019-05-08" version="1">MPSRETFGRKQYASSKGSFKFANSSDIRGSLASQNESALIEALTALRNQLTIRECETRVSADDERLILAKSWLDGSPGAQDIFDIWEGSNSRQHTLLALVVAVLSSLVALLSSHYTYHVLAYPIMRTLLSPQCTQRLNSYLGGSHTELLLVTLKLFNSMSDFAGGRERRAVLDSFAWETKSLPKLLHMRRKGKIKDNVDILVRPDIRTLYILFILSFVDTSSSTAVKAAFIEQRRDILSSIFKGLSQDPYSLVRRVLEICWTGIWSDAKIRRTLKIGLFSEAVLAQLVRLYERLAPENGESDHVPADIAHHFLLAICTRPGVGLCFQDRGWYPRESDLDDSAPLETGDEARLGHKSSKIYNKVLANVLKVLKVNEDPRQQELALKVLAACPELVAGYWSSAALALEPRISSKWITNIAFFGSVVSLPVPHSTFLNDDGQLYRPVPPPLGAIIENIVPSGNMKVHLSRGLQSPSALVRHCSALALAKCLVKFQAVLDVFSAIEAALEEDSEGQWYERRTEVEREIRKRIPDFQVIVGFSQRLGDSSSFASSSAGNHSSTIGSSVSHSPKRSLLLESAQRLLWLYHRSLPSLVAEARFDVGKLLQAFQDDVSGSHSSACRGFDTLRRLHVLRLLRESEQFTWSSKTGSHSHLYTLLRIYVSTQKSVIKKALAFLFRQVFSYSVIFQHDPDEITLWLDALPRTRRSQGATTLDGVPLTDEGDGVALFLDACAQQCSSNPYQYLEDLQTLSAPHAQNQDDSSTFNAQESSKYPSPLLITVLEQFGLKLRAKALSPSDALTIMSFLRKLVIRLASKSSTLCFLERFVVNVEDVTGFLFQEPLSMSPIILAAIRREACLLRSGLSQLRHFSASIAPAPTPAVQEFLARVEHLSNPISPEEQETSAYELVDWLRLADFPMHSSEVARLIAAVERFHKGALRELFEYLEPNQQSLWSSVSVADHFVAWRDQLSFRILILHCDDGTLADPGCRQIMVESLSGDSLEIADVKRATCLVNHRMLASRDDDPVVQNLLLLLQSMMEYSRANLTSEDFTGLVQTYFTSEAFREYCSKPATVAIRQSISNLLDISLDSSKDDDRLVVREIAGLWSLTVKDASQDTTSDKMATALLWTRYLDSDEILALFDSLSDAVDITPDRITVIEHLLQAVSPILSANPGAAKSRLRRLIRLRDLLPHSTTLEAVLATVSHGSLPLCYDSRPVLHSNESTNTLSHFVAQAQARWLQRLDSDDGHIQVDNFLMMDNITDAAVEIVTSVIYRRRTAKTATLRWLHVAASGRCSPLHLDRIILALCDSTEHSDILNQAEIPTLASHLQYLVRTIAERTNTTGHIETCSTCAACITSMVKQWPSLLLELLAALRKACELPVSDKSYSYFLMIGRQLLNLPGREVANVVDVLVDYGLVRAVHYFSSNATGSDEAAEALVDLAVLTEFSSSVKAHLAEPVLAAVIQHCMSNKEALRFARLLVEIAPMKPVTVNRILQSIVQHPQLYTSCVVSTDDASPRTAVIDLLSVLFHLHPLNTCQPTHVEPLRRIYGGTLSESDTKLLSIFRLFEKTRKFSISALLSSWSSSPDIVPVNALEAVQSLDPNRVFKTCLSFPDRRRLFDDTAEGSDADNLLYDPVFVVLLFAQVMAEGPPTSALSWMQLFRTNVVSLLVRTLSAEDNHLRDVAMAQLAALFKCLQDADVQEKPHVDHILNMLKDLVSKPSGDNVPRIPAYTTLLLAHSLRAIFYPSNFIYPLTARFLLQRPELDAHDVPMLFGMIYSSSDQWKKERGWILRFLSDGMVGSEEWKVLKRRHTWDLLASLFQSEERDSNLRRGVLEVLANITCNARATTSLVLKGSLLSWIELQLRSTRPSEGIAWIRILENVVCVVNHQIIEASTYGEWRSILSRCALMVLESSSHTEGVFPAAIPLLLRLSLLPGPPSSHIRLLIARCLSWIKAIESEVEFPPSGRLTRSLSHAEHAQVPSAPHYSRGLFEKPVCSSLRIWGDAVETLWRVSMTLEEKTGEWDELTCRLLIWRSMAGEGSSVGEWARREVLRNLESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTP7</accession>
    <name>A0A401GTP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized MFS-type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0801160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616511.1">
        <property type="nucleotide sequence ID" value="XM_027760710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTP7"/>
    <dbReference type="FunCoup" id="A0A401GTP7">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GTP7"/>
    <dbReference type="GeneID" id="38782515"/>
    <dbReference type="InParanoid" id="A0A401GTP7"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="139"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="580" mass="63117" checksum="44DE6C0FB7D63D32" modified="2019-05-08" version="1">MSQRSQSEIATIDLPWDDRLAEPQEIGLGGDLTPSSEETIGIPTISLTHDPNRADLSFPFGTTDVGRAGFTDEYRTTSRTGYIPADLALRPIPTHLSVIPDELQDPEKVRRLQSVKLVTWLKNDPEDPRNWSNAYRWYLTAVCAFSVVGAAFGSAVVTGDFDGLEKEFHVGGVVIALSVSLMVCGFGLGPLAWSPLSELLGRRPIWIIPSILYVIFNIPCAVAQNIQTLLICRFLCGIFASSPLTLAGGTISDIWDNNERGFAIALFAAAPYGGPVLGPVIGGFVGETVGWRWLFWVNMIFSGCSAVLIATIPETFAPVLLRKRAARLREKTGDRNITTEQEMFSASFSQMLVETLLRPFQMLVTEPILLMMSLYIALIYGLLYAFFFSFPVVFGPGGYDFNNGLTGLTFLSVIIGLLIALAVMPLVEENYHARAEAKGGHADPEDRLVGMMIGCWFVPISMFIFGWTSPPAVMPGGGNWVGPCISGIPFGFGMVIIYFSANAYLIDAFPGYVASALAAKTVIRSGSGAAMPLFITAMYHNLGNGWAASVWAFISLGMIPIPFLFYRHGRAIRARSSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU33</accession>
    <name>A0A401GU33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0802630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616654.1">
        <property type="nucleotide sequence ID" value="XM_027760853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU33"/>
    <dbReference type="STRING" id="139825.A0A401GU33"/>
    <dbReference type="GeneID" id="38782658"/>
    <dbReference type="InParanoid" id="A0A401GU33"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF84">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="171"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="614" mass="66237" checksum="D8530974E8E926A1" modified="2019-05-08" version="1">MKPIHKRLYTVLPRPAITSSPCSSTSRVRSNSVSSSRSLYAIPPSALPLSFYDSPAPPLPSSRPVNNLITTTRLTVEGKPEADAQPNTPYSNQYTPNTPQSHNHSAGPPPHSLALTSTHSESHIPGSHQKPFFPYQSFVPVFYNDATSAGAYGIPKRSRAGCVAGRDGHGKLGFAEGSLYPGEELEGLNRAVQVGEDAYFVRGNAMGVADGVGGWSRVRSHAKSSSTEPSPSALFARRLMHYCSEEVEAASLSEPASDGPELYMSDADSEEDTADLYTDLEDSLDELEEGLDVLMILEKAFDKTMRAHVAPQKVHSPDSWSNEKFDTEQKLSSRTVPSSGSSASTVSCPSTGGVLDLLSKPDTSAPISRCCSQGLPANSILKMADTPTKIRPPVTQGSSTALLAVLEHSPTPHAKSRCQSSLLQPQPRHIGEPHVGPQLGAILRIAHLGDCMGMLIRGEDVVWRTEEMWWNFNTPVQLGPASPTRPRDAHVFTLPVEADDILILASDGLSDNLWDEDVLDEVVRFRRPFIANGSWSHNPTPSAVRGVFARSTLAGMLSEALCSRAARASERRDRDVAGDNEVPFARRAREQGRSFHGGKPDDISVLVAVVSPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU90</accession>
    <name>A0A401GU90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0802750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616666.1">
        <property type="nucleotide sequence ID" value="XM_027760865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU90"/>
    <dbReference type="FunCoup" id="A0A401GU90">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GU90"/>
    <dbReference type="GeneID" id="38782670"/>
    <dbReference type="InParanoid" id="A0A401GU90"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE85753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="312" mass="35383" checksum="91D3C5092B8FE44A" modified="2019-05-08" version="1">MATTTFTQGERVLCYHGPLVYEAKILKIENWDETNSTSGVVGPHFFVHYKGWKQTWDEWVPAVRLLKWNEANIALQKGLQAQAQAAQAASSASSSKAASKAHHLKDTGRTRKEGGTRGTKRAREEDESSKRPEMKLHVPETLKVLLVDDWEAVTKNSQLVALPRTPNVVDLLEEYRKYVLALPMTYLKNPDTLLPTIIAGLQTYFDRALGANLLYRFERPQYADIRKQYVTGPTVQVGQEKEMSSIYGAEHLLRMLVSLPQMVASSTMDAESVGLVRDYVNELMVYMVKEQHRIFIREYDSASLAYQNISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV03</accession>
    <name>A0A401GV03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0800810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616477.1">
        <property type="nucleotide sequence ID" value="XM_027760676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV03"/>
    <dbReference type="STRING" id="139825.A0A401GV03"/>
    <dbReference type="GeneID" id="38782481"/>
    <dbReference type="InParanoid" id="A0A401GV03"/>
    <dbReference type="OrthoDB" id="3031254at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF550">
        <property type="entry name" value="MYOSIN-IIIB ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE85564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="107" mass="11978" checksum="48292275A2A49645" modified="2019-05-08" version="1">MSRRRASWLPPSSISVTLSSMDRSRNEDAAVVRNTDVLDIVADFLGVQPAALEAALSYRTKMLKKELCTVFLDPDGASDNRDELAKSLYSLLFAWLNEHINPMPLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVS2</accession>
    <name>A0A401GVS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0902070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617241.1">
        <property type="nucleotide sequence ID" value="XM_027761440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVS2"/>
    <dbReference type="STRING" id="139825.A0A401GVS2"/>
    <dbReference type="GeneID" id="38783245"/>
    <dbReference type="InParanoid" id="A0A401GVS2"/>
    <dbReference type="OrthoDB" id="2993683at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="830" mass="90081" checksum="62ED205AAAADE775" modified="2019-05-08" version="1">MKAAISCASTYMEHTMDVTFTLKPSVSVSASIVLGSSKPYIFSGSNSVLQWINLVNGTSTLLPGLSTDPLESWPSDATGDPTAVTDLMNVSYPAWMWLLAHATNMTLEDFRDVDRLQNATTSTFENMWPDFAQANLMVDPDTSGSSSTTVDGMVHSSDLKLIAHPLSVRLAQGTLSALIFVVIGVYILWPQTVLPRDPSSLAALATLLAAKEGTIDLDKVVSDTEGKSVSSNRSEMQLRFEEGLATVKSSDSTITPLRQQGDGTLPMWRPLTLHPITGTTLAVLIVGTIVALQYTYRYSMSHHGFGDSDTKSSALQTLRNYVALIYIFILIIMLSSYLSAIQVLDSYISLARSPMRAHSTVMYAPASCTQVGLVWHATQHHSIVGLLCAAMLMTLPFLKIAVAGLLITTSTLHQSPVALNWTGTFNNTYNFGSFFVINENGSAFPTGFQSGCPVGLVDCPVPGWSTILSQIPQFGLLLPDWVMATDAVGVVDVDPLGWLLDSVNVTVPLPMVSAQLFNCSALESSDYNYTVGFLEGVIFPNEKPGLIVQLPPSLDPVTCSNANDWACPSGEVPNQVMLTLPQKPGYFGEANALYGGYIFYYGKTQDNNASQITDLIIVECAYNITQSTKQVTITKSNTSTVPILTIDQSSVRDAEIVIDHGTDDGNLPYFIFPVFPLATNASQAFDTFNQILTLRNISAPLSAFLDPSYLIPAVQELYTAFWAIYANVYMRLPVNRSDASHPGKCPYAGHSSTPRRDPRMRTHATALIWSTGNALPFSPTSIGAQLRLIVSSRFSELEVLGEDVDNNELGKTLDSYRFALGWSNDIDGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVS6</accession>
    <name>A0A401GVS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0901950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617229.1">
        <property type="nucleotide sequence ID" value="XM_027761428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVS6"/>
    <dbReference type="STRING" id="139825.A0A401GVS6"/>
    <dbReference type="GeneID" id="38783233"/>
    <dbReference type="InParanoid" id="A0A401GVS6"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="294"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="665"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="189"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE86316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="736" mass="76742" checksum="7D316D413B96AC85" modified="2019-05-08" version="1">MSPAVVLDSPAMNMHLASLSRMQFNGHIHTPPASDHSRHDQSPTSPTSPSSPSLQAQQPRNGSAPYPIDPALRERNADNIDPALTQNTFIPSTSPSSNSSPPLSCANCGTSSTPLWRRDGDGKSICNACGLYYKSRRMARPSTLGRTSTAPSATHPNANPVTASSPVSKPAYAQNGNRQMSASPPPMLTPAASPPSASQNQSQNAPPGAEQKAAGQAQKGHLPGTCPGDGRCDGTGARVEVETTNGQAPAPASPVVASAGPTAPPQISEGEQPPAEGSPVISQAGNSRSRMRSTVGALSCANCGTSTTPLWRRDDVGNNICNACGLYFKLHGTHRPNSMKKTVIKRRKRVPAASGPPGSPTQQDRMTDQAAAEVLASVGRGHSGTSVGAGGTLEESEEEPPRRKRARKSRGKEVREDGMEVDDDEGDEEDSSKTAVPKRGRRSTGARANQRRTDSRGGASTGMGWQMDTGPSSPEHVRSASNPRAQELDRYGAGAPRGNPFSPNPHGGFDLPPLNAALGNGEMQVQMPMGMSLGMGMPGAHYGGPPGYARSGSQGAGGPSRTHSPLAGPGMGAPGGGYVLPPPHSLAHGHHVLNHGHHAPLPPPPGFYNPANPQVPSVGELERHYFELQEQRRKYQEMMERTDYMMAGVKRGLEDMRGAAAVAVAAAGGQQQGPPPTQVTAQPHVQGQQAQGKGQQQGQQQGQQQGQGQAVPIGRSPSGSGRESVWPVAPPESSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVU4</accession>
    <name>A0A401GVU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0901810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617215.1">
        <property type="nucleotide sequence ID" value="XM_027761414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVU4"/>
    <dbReference type="GeneID" id="38783219"/>
    <dbReference type="InParanoid" id="A0A401GVU4"/>
    <dbReference type="OrthoDB" id="2802795at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="111" mass="12535" checksum="B99879BC145B6355" modified="2019-05-08" version="1">MLYCPQEWSVVDSQHYFSVIKSCLKQCVASAPQNPGVLESEVPLSASGPEDDSQWKCVSFCTEGEEQIFYAYEWDRTPIPVDKRPKHRSAFSVIFPTDCINPCVDLTQEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVZ5</accession>
    <name>A0A401GVZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0902700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617304.1">
        <property type="nucleotide sequence ID" value="XM_027761503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVZ5"/>
    <dbReference type="GeneID" id="38783308"/>
    <dbReference type="InParanoid" id="A0A401GVZ5"/>
    <dbReference type="OrthoDB" id="5422293at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="199" mass="23043" checksum="8B372175C03E762E" modified="2019-05-08" version="1">MSVEPLPPSIDELLADRAKARSRYPLSSPHRWRTSRVPLPLFSRILRTPQPDTPSASFYRLYEFFVLDWNVQLRNELEYFCSMHPTWSVFDLPDPVDTDPVRYAALAVLTRLMCDAFNRRIGLGLPRDAPAIILDFEELQARPKVYEQPPEWAQRVPALQERVFIPDAQGNAPVEGDEDISEEFQGMNIIVRMPHIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW43</accession>
    <name>A0A401GW43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0903140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617348.1">
        <property type="nucleotide sequence ID" value="XM_027761547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW43"/>
    <dbReference type="STRING" id="139825.A0A401GW43"/>
    <dbReference type="GeneID" id="38783352"/>
    <dbReference type="InParanoid" id="A0A401GW43"/>
    <dbReference type="OrthoDB" id="2793715at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase core" evidence="2">
        <location>
            <begin position="239"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="534" mass="60125" checksum="B0833F4C56D71F6E" modified="2019-05-08" version="1">MSQQLDNLRAAYHVLKERVNRALRTQLGDVGHLGEQRDQVLSFVAAAEAHQLAFPLVEFATLRRSAGAMLEALDLACHRSSDPLQEDPLVVAHRYHTGKRGRPRVEIDRLFLEQALALRGNSAIALVTGCSARTVRRRALEHNLVLPGAPVYTDRIAANGTISRTYRSSTAPTSQLTDDELDTFIAAVLDVFPDFGRRMLDGRLKASGHNVPRLRIAGSYIRVHGAPGMFGNRTIHRKVYKVAGANSLWHHDGQHGLIRFKIVIHCFIDGKSRLITGIRASNNNRSNTVLDLFLDSLHVHGTPSRVRGDHGTENVLVAEWMEVNKGSGRGSYIWGSVHNTRIERLWYDVTHGFGQKWKNFFLDLEVNHGFNRRLAAHIWLLHYLFLDAINDDAQEWAHAWNSHRLQIRGERSRSPRDIFLFSMVQDGPRGLSRVRNAVNEVVDDPSLTHKIGRMIIPSASVPRLYLMSLAIPQIVHSLRCKSLLLMLALPLLLTYTLATWLCAVLSGRMPSSFVRSCGHLEHRLLTTFHIFTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW49</accession>
    <name>A0A401GW49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0903360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617370.1">
        <property type="nucleotide sequence ID" value="XM_027761569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW49"/>
    <dbReference type="GeneID" id="38783374"/>
    <dbReference type="InParanoid" id="A0A401GW49"/>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18049" checksum="876EF5BB04478BDB" modified="2019-05-08" version="1">MSPTRAHLQASAEALCSAFAAKADLETLLSHFSTTHQVSAVEYGLPLLAPFLGRRFTGLGGPESISTYFSLLTQYLTYEDMSFGEWVVDTEARKVCVKGRAKFTWTEGAGKGQSWDERFVYVLDFDQEGKVTDYQVWADSGAAYLARRGELADKAQEFQMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWW3</accession>
    <name>A0A401GWW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0905520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617585.1">
        <property type="nucleotide sequence ID" value="XM_027761784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWW3"/>
    <dbReference type="STRING" id="139825.A0A401GWW3"/>
    <dbReference type="GeneID" id="38783589"/>
    <dbReference type="InParanoid" id="A0A401GWW3"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="274"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="399"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="620" mass="68692" checksum="4A4109DE6074E146" modified="2019-05-08" version="1">MNILAPDVSMAGNHDFDFGYPHLSKLIEDTKFPWVLSNIIDNTTSRIPDHLLEYYVLERAGVRIGVIGLVEKEWISTVPTWPENFEYRDAAEAGMKLSKILRDPNGAHRCDIIVALTHARVPNDITLAKALNALSPSAQLDQPIESKHGVDIILGGHDHVYYVSRGVTSWEGYDTNTPVLGAEGDLGDVLIVKSGTDFRDLSEFTLELADTCPGSVRRKVIKEIRGRHHATQPGSKKSKVLTELLKTLLSSVSSALKAPVCKTDVELDLRSELIRTREISSTNWFADVLRHAYDEALSCGGGTDGVFICAGTLRGDSVYGPGCITLGDIMEILPFEDPVVVLELDGQTIWEALESSLATWPAQEGRFPVISGFRVSWDSRRPPGQRVLGVWLVQETSGSMTPTPVPSASSSMTSLQSLPSGATSSAVSLIDGDPIPRERGGRQYRIVSREYMAQGHDGFLMLKGRRYLVDDESGQLMSSIVRKYLLGARYVNRMARLANHTEVPHLHPDTADLISREKVRREHYARRAKPPTRIDKLRNKVRLVATALRWSRAHYRDHINISAREHMSGVDCINGEVMRAATSLDSRVQEVTQDDEKTGDEDLVVIHPIVDGRLADEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY75</accession>
    <name>A0A401GY75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1004000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618066.1">
        <property type="nucleotide sequence ID" value="XM_027762265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY75"/>
    <dbReference type="GeneID" id="38784070"/>
    <dbReference type="InParanoid" id="A0A401GY75"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="203" mass="22199" checksum="880816CA57097347" modified="2019-05-08" version="1">MGSPDARPAGEAPASICSFAVQPSHAPQVLMVQAQSEAASMGIILPLLHDIPVLAQVEIHFATARTIEGGRRMIPQIADHLPAVIPRGLTARVLYDDPAICEDFDLGHPLDGLPYIGARSYCPYFPGIMFLSFLSPSRTLHLQVETLRNAARELYDVMRGITGRCELADDTLRRLRIVVEELEVVFGLVAFPPPITSFQLVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GY85</accession>
    <name>A0A401GY85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1004140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618080.1">
        <property type="nucleotide sequence ID" value="XM_027762279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GY85"/>
    <dbReference type="STRING" id="139825.A0A401GY85"/>
    <dbReference type="GeneID" id="38784084"/>
    <dbReference type="InParanoid" id="A0A401GY85"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019412632" evidence="7">
        <location>
            <begin position="21"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="57"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="569" mass="60748" checksum="2837F7F1AC603D47" modified="2019-05-08" version="1">MLVVPLTLLSLCSCFAAIYAATDHNPIFKNTTAVVTVNTTNEGRLGFTNSWMLIGMYTATVYIQGQPFQVVIDTGSSDLWIYNSQNLTLDGLIPTGHSENVTYDDGTYIDGPIVLANISLGQYTVQAQAFINSGSAAAEIARSADGILGVSSPFASGIFQNLYHNSTDNGWPFLSNLFNNNPDMEPYITLYLTRSAVGVVDGGALTISEIVTNFEAVLEAPPLPVYSDDTFSTFMDGVYLDGKFLTGNSFGPNGTGVNANPGPNQTIVILDSGTALMIAPPYYVHGIYKDIPGAQWIPSIRTYSVPCSTKLNISMVFGESIYPVDPIDSTIVGVSDDGSLKCIGAISYSGASVGADFILGSSFLRNVYTLFHWGNWTENRTNQPYMQLLSLTDPDKAWANFDTLNLERIGQTEQQQIQDNQNYTYPKTVSQSVTYSLTSPSLSATHSAGASSTSGPSASTLSPSTASTTTPAAAAKLDAALAEASGGASSSSTVDLGGLTRNSYIIMGLIAGVLVLLLGVLIKLVSDGRNQQYRAVPNVIRPPMHFSDKPYEPESEAFVTPYDDPARPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYA4</accession>
    <name>A0A401GYA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1004430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618109.1">
        <property type="nucleotide sequence ID" value="XM_027762308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYA4"/>
    <dbReference type="STRING" id="139825.A0A401GYA4"/>
    <dbReference type="GeneID" id="38784113"/>
    <dbReference type="InParanoid" id="A0A401GYA4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="37962" checksum="A4C967900BA9BEEE" modified="2019-05-08" version="1">MDEGRHHVSQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTMRGKGRSVHRPYYSASAKDPNAMDVDRVNISCLSPDERQKRMKEGLCFLCGRKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYC6</accession>
    <name>A0A401GYC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1000460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617717.1">
        <property type="nucleotide sequence ID" value="XM_027761916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYC6"/>
    <dbReference type="GeneID" id="38783721"/>
    <dbReference type="InParanoid" id="A0A401GYC6"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="365" mass="42161" checksum="0E206D37DDC12923" modified="2019-05-08" version="1">MDHHATPAPPVLRKRYVGPYALGESEIFWSEHYTYLARQGYQLRDRYRPDWSPSWLGTETNPEDCEDSVIALKMNSMDATRQDGLCVRIKHVERGKNERKVVSYLKDTVESENYVPLVEFLQDPLLPDKDFMISLYLRPFYNPGLTNASHMVDFVMQTLQCLAFLHGKQVAHRNCCADNIMMDASSMYPMGHHPVRLECARDGVSEAVLTNCIRRPVRYYFVDFSRASRFREGELRPYARVREDLDKCLPEYKMAINGRLDTFKADVYRLGKLYQTTFLGAQYLRAGWPLASLQTLVTAMMHPQPEMRPTASRAIEIVQYVFREVNTTPYMVMWTTPQPPAIASPVGMWYTPLNASWPTTSSPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZC7</accession>
    <name>A0A401GZC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1102020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618438.1">
        <property type="nucleotide sequence ID" value="XM_027762637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZC7"/>
    <dbReference type="GeneID" id="38784442"/>
    <dbReference type="InParanoid" id="A0A401GZC7"/>
    <dbReference type="OrthoDB" id="8169885at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18292" checksum="86CEB684CB6B876D" modified="2019-05-08" version="1">MDAKRDALGLTKPRHLVISGERPPGPGESVALPFFKIDSVLALHMGLREDFDGLIVQLLACCPRLRALKLSGPFEGTGLSALSRVLMAVATSPNVEYLSLPSINFKSEDLRLIDATVASLSAHLRIHCPMLCYVCVQLTEIDVPVHFAQHRLLRFDHFRVYETTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZN6</accession>
    <name>A0A401GZN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1102760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618512.1">
        <property type="nucleotide sequence ID" value="XM_027762711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZN6"/>
    <dbReference type="GeneID" id="38784516"/>
    <dbReference type="InParanoid" id="A0A401GZN6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="129" mass="13383" checksum="38903FDA063D3E6D" modified="2019-05-08" version="1">MADVGEKDRMAASAVPPAAPPATAPATAPAVAPATAPATAPATAPATAPQPAPPAHAYGAPPGGEKQRVTQPSDMALFFLALFIPPLAVFFSKRGITSDFWINILLWILGWIPGVLHAWYIISRSQGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZQ8</accession>
    <name>A0A401GZQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1103280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618564.1">
        <property type="nucleotide sequence ID" value="XM_027762763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZQ8"/>
    <dbReference type="GeneID" id="38784568"/>
    <dbReference type="InParanoid" id="A0A401GZQ8"/>
    <dbReference type="OrthoDB" id="3247268at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="195" mass="21339" checksum="6191064251BBADD9" modified="2019-05-08" version="1">MTEQINFSLSQLSLQSPGSAGEEDWDRSMQLQSEPELDRRTPRNSVVFPGNTDNSGEGDTGDAPGRTHGQSTGGGKPKRTLSELLRLHAANGPDGTFSPEEANRVAEVLGQWINSSSSPYESEDDFFTPHSILTFDHEAKVQALPVNHDRDAKAPVVSSSDPSNHPRLSSCWPLDIYIPSNVATIYDVSRRYDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZY8</accession>
    <name>A0A401GZY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PARP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1104100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618646.1">
        <property type="nucleotide sequence ID" value="XM_027762845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZY8"/>
    <dbReference type="STRING" id="139825.A0A401GZY8"/>
    <dbReference type="GeneID" id="38784650"/>
    <dbReference type="InParanoid" id="A0A401GZY8"/>
    <dbReference type="OrthoDB" id="9514740at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31681">
        <property type="entry name" value="C2H2-LIKE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31681:SF3">
        <property type="entry name" value="OS04G0690100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARP catalytic" evidence="1">
        <location>
            <begin position="227"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="37331" checksum="21D255B86F4682C2" modified="2019-05-08" version="1">MAQLEGKKLCKKCNARPVYVQNGRVHDFCGIRCANAFRSGTPVPMSPRASPAPSGNSICRLPGCRRRVWTGRDGIPSQFCSNRHRRDAVRTGNAEGCLLCNQLPKAVVNGKLTDFCSKTCSLDAINAAPIILQVNRSHAEFYSVKRQFSEGWKHGTNVPAVVHVWKIYGEKGIYDKFARYKLGVERRTSLKGGNTCRRWHGTVRACQLGNDDGMHELCRNPACSLCEIIRSSFQLTRVGQRTNFGRFGAGIYTSATSSKANDYVAEWGDSPYRAMLLSKVVMGKAIKLQMGDQRLTKPPQGYDSVVGEPGGDLNYDESIVYKNEAIRPLFLVVYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0N8</accession>
    <name>A0A401H0N8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1201880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618875.1">
        <property type="nucleotide sequence ID" value="XM_027763074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0N8"/>
    <dbReference type="FunCoup" id="A0A401H0N8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0N8"/>
    <dbReference type="GeneID" id="38784879"/>
    <dbReference type="InParanoid" id="A0A401H0N8"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019358778" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="94"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="437" mass="47950" checksum="FCDC0607A5B98C0A" modified="2019-05-08" version="1">MPRILLLLAVITPLCSVFLVARSLFPGFDLTKVAESFPISWPLAVPADSETRPYDESDQQPLDVVDFSPPHDHSSDLHASVAEPITVPGQFTRRIVAVGDLHGDFPNAQTVLQMAGVVDHNGNWTGAVDFLVQTGDIIDRGDDTIKLFLWMEGLRDEAHAAGGTVLSHLGNHEWMNVIGDWRYVYPSEITTFGSVAARQKMLTTGRIGKSWASNYTTASRLPLHPAVGDPNIDYDPSTASAFDVPTPLSHTAISFVHGGLAPSYPDLAPFPSRINELSHSLLQKLQQRTPPPHPPNPYPGMPAEATEAERRLYDTDGPLWYRGWASGPEEQVCAQVDGVLQKTGTRRMIMGHTPDFQNIVSRCKGKIIIIDTGISHAYGGTLSALSITYTLTPIPAIHTSPEEKWWTEREVLVAVYPDRQEVLAVDERDIQGDFAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H150</accession>
    <name>A0A401H150_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1203870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619070.1">
        <property type="nucleotide sequence ID" value="XM_027763269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H150"/>
    <dbReference type="STRING" id="139825.A0A401H150"/>
    <dbReference type="GeneID" id="38785074"/>
    <dbReference type="InParanoid" id="A0A401H150"/>
    <dbReference type="OrthoDB" id="2767275at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="204"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="460"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE88157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="538" mass="60818" checksum="C811BE12DA124ADA" modified="2019-05-08" version="1">MDGISSLSAILGVLQVLGSATIAVYKYAASVKGAPAACDRLLQELSAIGGTLGHAKVVLDGLQGHDDFSSNHTLKITAFLGGTGGPLESCRATIEELCAWLARDGDKRMRVDRRMLWPFQEKELMEFVQRLERHKTHFILALSLNSADSLMHLGNSVEDVKKEQQRVKDEKARQELQMDLRELIEWLSPLDVDRMALLKQWIPVLQGIPGSGKTILVSTVIDELKSSCSGGNEEAILAYYYCDFSDSKSANPVTVLRTLLTLFMATIDDDSVDTFVDLLKRKKATKSPPDDIELLQLLLLRAIGERKAIIVLDELDECVDRRWLLEFIPRLVHQASVRWLVSSRREQDIVGAFEDFHTISLSHEFENVYADIQRYIMQTLETEPRLRRLDSELKAELGSALLHKADGMFRWVQCQLDFIITRRTRQSIREALRTLPRGLYPTCERILKRIEDEGEESALIAKTTLLWLVSALRPLKLVEVEEAIIIEVGSESLNDDARVLDEHDILEICSSLVDYDDSTDIVNVSHYSVQNFFFLTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1D4</accession>
    <name>A0A401H1D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase 12 kDa subunit, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1300610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619159.1">
        <property type="nucleotide sequence ID" value="XM_027763358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1D4"/>
    <dbReference type="STRING" id="139825.A0A401H1D4"/>
    <dbReference type="GeneID" id="38785163"/>
    <dbReference type="InParanoid" id="A0A401H1D4"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="78" mass="9187" checksum="64E23B51E9F575F9" modified="2019-05-08" version="1">MPVDEARAAELKARLKEQDEIIRESWVRAMEAKIVRDNITKCYRIEGVNHGEKCKELVDRYAVMLKENRVQGYKHIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1H1</accession>
    <name>A0A401H1H1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1301010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619199.1">
        <property type="nucleotide sequence ID" value="XM_027763398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1H1"/>
    <dbReference type="FunCoup" id="A0A401H1H1">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1H1"/>
    <dbReference type="GeneID" id="38785203"/>
    <dbReference type="InParanoid" id="A0A401H1H1"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="125"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="357" mass="40851" checksum="606979E72C6661F9" modified="2019-05-08" version="1">MSITHAETIYTPLPPPNISSKTVKEPPELSLTSDHQRLFDEVLAHYSNEKYTIPAVEDGKLREEEKFWLSYECLLRYLRATKWHSAHGVIKRIDATLKWRREYGVYDLITASYVEPEAVTGKMVLFGYDIDGRPALYLRPSKQNTSESIRQLHLVVWLLERTVDLMGPGVETIALMVDFADRSRSPSFGQSHATLNILQDHYPERLGRALITNVPFLLNAFFKIITPFVDPVTRPKMRFNPQCVSEGLFEAPQLLREWGGDCVFEYEHEQYWPVLVQLCAERRAKMREGWRARGATVGVREWDIKVAVFGEGLQDTPNGDVQVTERVEIAANGHVAKAPDEKVAVREIEAEKVQEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Z9</accession>
    <name>A0A401H1Z9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1302920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619389.1">
        <property type="nucleotide sequence ID" value="XM_027763588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1Z9"/>
    <dbReference type="STRING" id="139825.A0A401H1Z9"/>
    <dbReference type="GeneID" id="38785393"/>
    <dbReference type="InParanoid" id="A0A401H1Z9"/>
    <dbReference type="OrthoDB" id="2737640at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="250" mass="28230" checksum="22CFB007352F9E6A" modified="2019-05-08" version="1">MGPGARHSTLDDHWSSWNWRKLVDLNSHLLKHLIEALLMSKKHCEIAERFSSTFMPTTIIKWQEMIADWNADKMQPDPYAELTASTTMVTIRLELAEEEALEALQGALPLHDQLTASKFICLGEGVLRNPLKKSTLQEKRNTLTWHIKTWMGFQATYMPVVPMFRNTDTLNKTAAEENRVTPTEHLKLYLLSELVQPERASGCRAGIANKERQFRITSGGHHCITIAHNTGQAIVHNSPAIVIVITLGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2H5</accession>
    <name>A0A401H2H5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1400120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619521.1">
        <property type="nucleotide sequence ID" value="XM_027763720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2H5"/>
    <dbReference type="FunCoup" id="A0A401H2H5">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H2H5"/>
    <dbReference type="GeneID" id="38785525"/>
    <dbReference type="InParanoid" id="A0A401H2H5"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="313" mass="34645" checksum="7C3F8A6001D2CD34" modified="2019-05-08" version="1">METKYSDQRIFFASWNRTRDIRALNEMLVNIARKNPYIPELNVLVVGMPNVGKSTLLNALRNIGIAGPTPKALRTSSQPGLTRVLSTRLKLSVDPLVYSYDSPGVMLPFLGNGDKGAERGVKLALIAGIKEGLYDVEALASYLLYRLNVLDPVSPAYLRILPPGTPPLVDVLEFLDTLARRLCMLKRGGVPDQARAAVWFIGWWREEGGLLSASAPLLAASPSPTLDPPSQRRGWGFDVEWTVNADEARQYDTAVIQRKMEECIDAFERAALEEEREGGGVSSTQEKKRIKEQTIAKRVAKTRARLTAKRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3N9</accession>
    <name>A0A401H3N9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1500230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619934.1">
        <property type="nucleotide sequence ID" value="XM_027764133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3N9"/>
    <dbReference type="FunCoup" id="A0A401H3N9">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3N9"/>
    <dbReference type="GeneID" id="38785938"/>
    <dbReference type="InParanoid" id="A0A401H3N9"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="341" mass="36528" checksum="17526EFFDD9106B8" modified="2019-05-08" version="1">MSFPSRISAITISKTGDFDVIEKTEVPFPKSEPGHVLVKTSYGGVNFIDTYYRKGLYPIKTFPFVVGSESAGTIAALPADQSVLADEEFKLREFKIGGKVAVYGPGAFAEYVSVPWDSVFPVPDAVTLNTAAAALTQGATAITFMNEAYDVRKGDTVFVHTVAGGLGLIFAQYAKLRGATVIGTTSTEAKAAIARAHGADHVILYPVEDTVQRTLEITNGEGVNVVFDGVGKDTFENDFKILRRKGTLVSVGNASGAVPPFSPLKLAEKNLRLLRPTLGNYVATPAEGRRYSTELYTLIAQGALKINVHREYPFTAEGVQQAQKDLTGGKTTGKLVIKIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H423</accession>
    <name>A0A401H423_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620109.1">
        <property type="nucleotide sequence ID" value="XM_027764308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H423"/>
    <dbReference type="GeneID" id="38786113"/>
    <dbReference type="InParanoid" id="A0A401H423"/>
    <dbReference type="OrthoDB" id="2757264at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="370" mass="41479" checksum="6A8A337F13421760" modified="2019-05-08" version="1">MPRSSTTSPRRPRFSAEFALLKSELCRIRFLPTYNERSHKLVPMPYPAYPNGDAVTPYLLDFYAEMYEWEKPRCLCGHLPGRSSHPCQIKIPESDKSLNKGRPVLICSHFLCPMFVDLYDLLEENPDLERRTYPLREADRPSSQITGMARSCSAPPSRAQQRFGSAIRTVSNKDIVVEHSSPSLLAQLSGVSSQFDWQPPFKQASPTCSPYVRGDHPLHAAVPQELCSAPSSSSSSTQNSMSSPPLSQYGARQETRQELGPDDPQPPNCYDHGYLDSLERFWSPPPSINTLAYQVEAPSANEASRLFGLLDATVDPGVRYTELTRILTRCPFCEKLMSHRALYSPGHACSEYFTTAKVGTKRHYVDLTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H445</accession>
    <name>A0A401H445_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1501230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620033.1">
        <property type="nucleotide sequence ID" value="XM_027764232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H445"/>
    <dbReference type="FunCoup" id="A0A401H445">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H445"/>
    <dbReference type="GeneID" id="38786037"/>
    <dbReference type="InParanoid" id="A0A401H445"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="35"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE89120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="493" mass="54217" checksum="FAA47E50E43ED64F" modified="2019-05-08" version="1">MLRLLSRPIRTVAPIFRRTMASTPDFNKPLYTPLAELDPEVQNIIDKETWRQFSGLELIASENLTSRAAMEANGSILTNKYSEGLPGARYYGGNEYVDELEILCQKRALQAFHLDPAKWGVNVQPYSGSTANFATLTALLQPQERLMGLGLPDGGHLTHGYFTAKKKMTASSIYFESRPYGLDHSTQLINYTGLAEEARGYKPQLVICGASAYPRDWDYKALRAIADEHGAYLMADIAHTSGLVAAGELADPFQYCDVVTTTTHKTLRGPRAGMIFFRKDKDLQKRVNDAVFPACQGGPHNNTIAAVATSLLQACQPTWKAYAKQVIANAQTLGEELVAHGYKLQTQGTDNHLVLWDLRPLGLTGSKLEKLCDLVGITINKNAVSGDASAQVPGGIRLGTSALTSRDMLESDIKVVAGFLHRSVQLALVLQKEAGSKLLKDFLRVATVEEEGKQGARLVRELRREVRVFARRWPVPGVDVSTLTRPAGIEEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4N9</accession>
    <name>A0A401H4N9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable xyloglucan-specific endo-beta-1,4-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1600450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620297.1">
        <property type="nucleotide sequence ID" value="XM_027764496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4N9"/>
    <dbReference type="STRING" id="139825.A0A401H4N9"/>
    <dbReference type="GeneID" id="38786301"/>
    <dbReference type="InParanoid" id="A0A401H4N9"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019554181" evidence="3">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="25874" checksum="540CC9CE766EE653" modified="2019-05-08" version="1">MILSLVFVSALAAMARASTTITGQYDCVTGGNYQLCNNQWGISDGTGSQNATLISTSGNTISWSTTWTWANNPNDVKTYTNVESTTAKGVLLSAITSVPTSWDWEYVTESSGIRADVSYDIWIGTTANGAQASSSSSYEIMIWLSGLGGIQPVGSLSKSGVSLAGYSWNVWEGPNSNWETISFVSASGNLTSFSTDLNTFFQYIIENYGVSSSLYLQGIETGTEPFTGSAELLTNSYSVSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H519</accession>
    <name>A0A401H519_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multifunctional cytochrome P450 monooxygenase af510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1601310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620382.1">
        <property type="nucleotide sequence ID" value="XM_027764581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H519"/>
    <dbReference type="STRING" id="139825.A0A401H519"/>
    <dbReference type="GeneID" id="38786386"/>
    <dbReference type="InParanoid" id="A0A401H519"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE89469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="546" mass="60858" checksum="48F16683A240F9C8" modified="2019-05-08" version="1">MRSIKVPLSPPPPALFLTIVTLGPIVRNAAIQTPCHAPSAVPLCACVVLLAFILLGRRRKSTLPLPPGPPADPIIGHLRKFSFAHQHELFREWAAKYGDIFHLHILGHHLVVLNSLRVATDLMDKRSAKYSDRPSCTTLKLTGWDVSVPFMEYGPRWKIHRKIFQGYFNENESLKYRAQQTKGAHVLLKDLLVSPHEFTTLTQRFAMRGVLEIAYGHQVHSDNDVYVKLTADALHGADEVKLGASPVDFVPSLVHLPHWLPGCSSLTSAARRWRPATRKVHDFPFDDVLKQMDAGVARPSFLSSHLEQYNAEGAKNYNLDDLKGAAATILIAGSGTTWSLIQTFYFSMLLFPEVQRKAQAEIDRVIGSDRLPDFSDRDALPFVECVLQETIRWHPVAPQGIAHRSVDDDIYQGMFIPKGSIVFPNVMAMSRDETVYKDADAFYPERFLPAPAGPGEPYLGAVFGFGRRICPGRYFADNSAWIVVATVLATFDICKAIDKTGKAIEPDVAFTTDGLASRPKPFECVFRPRSEMAKKLIMQHANLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H540</accession>
    <name>A0A401H540_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine-protein kinase SRPK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1601960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620447.1">
        <property type="nucleotide sequence ID" value="XM_027764646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H540"/>
    <dbReference type="STRING" id="139825.A0A401H540"/>
    <dbReference type="GeneID" id="38786451"/>
    <dbReference type="InParanoid" id="A0A401H540"/>
    <dbReference type="OrthoDB" id="2791589at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="94"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE89534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="463" mass="51876" checksum="CD6ADBC071100DF5" modified="2019-05-08" version="1">MLSRGLSRATFSKSRLALASRTFVLQRRLLCKPPDQTIIDVAGHKSLSEGDTSTDAVENVELTFVEEPLGLRADQGFGYLQVDFGQRIGPGDRYEVLRKLGWGMNASVWLARDHEEECYVAIKALKGMATDIHFQGYMQELPIMECVTEHIQQSGRPAYCATLRSHFIHHGKPNDGEHLCLVMDVLAGDIEALQTESKAFPVPLAKRILRDTLRGLAQLHASGCVHTDLKSANIMCNLPEATSEANLRLLLESSPSRRHPPEQSWDYFVEAAVSQPLPPPSIDQALSASFVIGDFGSAQFADHQVISHITPDTLRAPESILQGPWDSKVDIWTFGCLVYEFMLGIPLFPRKHPVMEPDVYHLIQILKFTGEEFSPNLIKTYKYAPDFLDMETGYLARVRKPVTKVHFSLLFRRNAGVLALPEHDIAGAIDLMSRCFRIDPADRPTAIELVRESPWMLELGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H549</accession>
    <name>A0A401H549_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1602060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620457.1">
        <property type="nucleotide sequence ID" value="XM_027764656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H549"/>
    <dbReference type="GeneID" id="38786461"/>
    <dbReference type="InParanoid" id="A0A401H549"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019240495" evidence="2">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="134" mass="14259" checksum="DE815F236EBB316B" modified="2019-05-08" version="1">MVSFLRVLAVLATILSPGMLVHAGKDDKPLKLYGDPPVSSKPNLQWSDQGARAPANVGHQLPKNRASVDPPVSVKPNLQWNNQGGHAQINIDHQLPKNRGSVGGHVGYEWRGADPTRPGAGAPYVGGRVVINIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5S5</accession>
    <name>A0A401H5S5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1700340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620623.1">
        <property type="nucleotide sequence ID" value="XM_027764822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5S5"/>
    <dbReference type="STRING" id="139825.A0A401H5S5"/>
    <dbReference type="GeneID" id="38786627"/>
    <dbReference type="InParanoid" id="A0A401H5S5"/>
    <dbReference type="OrthoDB" id="2740102at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="262" mass="29882" checksum="7AFE92EBF6EEF521" modified="2019-05-08" version="1">MAILYFPDVYSEEEHPQLYDLHSVGDLEDDMELTIANVKLMKKGETATVYRASVDGVAYLPEGAAPPPMDIVCKDLQGIAIPRYVGLFQGEMEDGRCACLVREYCGERLRKPLCGTKWDFRGEVVNLLRQIHDKGVEHGNFSEENIVIDVEGRPFLIDFSEAEKHECEATMPITIDDIQPMLKDFGCRELFNAAVLAEVWLPGKILFMGFYVPTQFAQSPEMLATCAPEGVSPDEALKAGQEYYDMFRSTFEKRRRYEYYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6I5</accession>
    <name>A0A401H6I5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1800780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620969.1">
        <property type="nucleotide sequence ID" value="XM_027765168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6I5"/>
    <dbReference type="STRING" id="139825.A0A401H6I5"/>
    <dbReference type="GeneID" id="38786973"/>
    <dbReference type="InParanoid" id="A0A401H6I5"/>
    <dbReference type="OrthoDB" id="5562739at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE90056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="475" mass="51900" checksum="FD7912E2C356369D" modified="2019-05-08" version="1">MALGANRSANMSSGLLLDHMPSPSSEPVTVGPRFRPYASPNHHVTKGRYITSNDPRGYIPVHEYPLNGQWIMLDMDDGYVLWTGIWKALGNSKADIVKIVESQPDLASQLRRVRGGYLKIQGTWMPYETALRLARLVAWPIRYDLVPLFGPTFPSTCLSPDQPGYGQIVKPGSGKRRSRRTTQNDIPPDSRHEWTVISPTLAASASTSSASTRPQAVNSALSGRELSHSHQYQAGSPVMLHVPYAQGAYHTPPPMNGLHSPYAQAHRHSPPLDIRTNIRYSPYPSSLSSPPAVYEVDVRPMHFESIKLPSIQPPTGRLGNNRSGSFTLPPISSLDLREGQRVDDSFTILRRLRSDDDADVAGGKSTVAQALHRRCVGPPPEYSTGRQFSQISDLTSASPSAPSTSSSNRSGGSRTGASSRGEPAPHLAPFSGEARHVHMPVTTSSAWEQRAPPLPPSARQADNVPEPARHAWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6M3</accession>
    <name>A0A401H6M3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1801080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620998.1">
        <property type="nucleotide sequence ID" value="XM_027765197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6M3"/>
    <dbReference type="GeneID" id="38787002"/>
    <dbReference type="InParanoid" id="A0A401H6M3"/>
    <dbReference type="OrthoDB" id="2797107at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE90085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="449" mass="50741" checksum="8F9ECFD4E38A8B5D" modified="2019-05-08" version="1">MSGKRCNPWSGCSSPRGRSPTPPPLRRAYWDEPGTPTGSHRPRARPQCSGENLYAQSSPRGSAAPSRRPTPSPNAGGRRYRPLGEGGAEHWTLHKDTDHSSHMNLTKLPHKLTLTNYVSWMTTMESTLDTIKLFEYATGEVPEPDPDVDEARARRWKRANACVRLILALNMTEEVMSQISHLMVVAQVWQEVRRLFAGETLTDWMLLITSLVTTKYADGEDLTLHIAKMKAYRRDLILMSRNIPDDLYACFIRISMPQSWNYIFSGLSQYYTSSEIERRLKEEYAIRQNQQSTARAYNAKQQSGKRSKKEYKPGDPFCKNCERPGHYIKDCWSKGGGAEGKGPRSKKKEKKDSEKQDVKGKERVNEVKEDSDHLSCMAAPGSSSRFTWILDGRSTTHICRTKSAFVTFTPLSETISGIRKTGPQLEVHGRGDILILCHVHSGDQHIVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6R7</accession>
    <name>A0A401H6R7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1801600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621049.1">
        <property type="nucleotide sequence ID" value="XM_027765248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38787053"/>
    <dbReference type="InParanoid" id="A0A401H6R7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
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            <begin position="1611"/>
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        <location>
            <begin position="154"/>
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            <begin position="1215"/>
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            <begin position="1304"/>
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            <begin position="1450"/>
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        <location>
            <begin position="1611"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1730" mass="181877" checksum="A110FD7244AF10E1" modified="2019-05-08" version="1">MPQAYPRSARERPPARSGRRGIATNLGAGPSTRTANVLTTYPQGSRKSSISSASWTPTDLGAYILETRECFRDAEVLSGFIKQHKFTLPGLLQLEKRDIKEVANHQTSLVQDVRRLIEIFRPKLHSPVQSRHPRLTDAFPHLPIPTQPHPRSSDIPNTSSEENVSDTSSFIFSDDEKNLKSPGPMPTAGQDSPVGDGVQQVSERSPAAARVYLQSANADGDGASKPEIRRGADPEIPAVGPARPVAPTNPLVSCDKAAAAESQPHEHIDDRSSQAPTHASTQESHEHVAALPTVSASSDPGRPPAWTSKENLDTISAQSGPSVSSQVGKAWPPAQEKTNGNAVVPASDAAAAATPTTSDSTNAANRSTSRPAVETPHRAPAESREITGSGERAGNGSANVSSRAAVGGPASRTVRRRGPVNTEQRHAGETTQSAPTSSPAATVESDPTTAEQKDTDTTQSAPTPTAGTTVHELASAEQAGTDAPIPSPVYSPTPCGSASTATEQRGISGAADAQTVNESAGASSVMQDQADFIRCATELIVGKLSPHEGVGSVSLDKKQGCDALSSQQVTRPTVQANPVTGAVHPENADSQSSSNMVSISDSDAQTSSAEPMEDSSSSTLVKEAHESHLHATTQTATQDGMLAQEVDMSADQTSITTDRASSQTPDPKSLASSDIKTTKASNDTTVEISSTTMTGEPSEQPNAYISLGSGAQQGAPPVQVESTKPLFKEGSQEVNSPAGRAGSVNVERSTELQSSGITSDSTLGASTKEPTRDSSAAWETQLSRKSNAQPIPTSPTQAIISRQDTAHDAVQSQQADMDRSRRGDSVAKPPAETPVAEHGTSSQVAEPEQDSVNVQANTSPSQTSTIADAASSPSIKLHPSATQGAASHISTTGETDTSRLQPEGNESRTPDTQPTAPQEELPAQPAKLLNADSSDKQVDDDSACPPYEGSSTGQTVTATDSSSNHPFLWQFSSEGNATTAPSIVVHPTDLIGRGAALQPDAEKAEPQTTTEEEIPHVQASVFESSKGQANDNERSQRGNGPDSQISAEARAMESRNIDPRSSEGDSTATRDTHNSSLSMEITASREPETEHVATQILPAQTNIKRSDGQVDRDGAGPLQEMNIGSQTANAAIDTMNSVEIIDVSSTGEGTSGVPIVVNPSEASVTDPEAQRSHLADLDMQTEHYSVIPQQVDTVISQEITITDVGSSRGADPYSSLATEGTPNDGTNTARDSTMGTPQREATPPSLDRQADGDNSEGCHVDIGLPRATTTEGDAPDNVNAISPATPIPAVCETRREMNVEERSQGSATNRGNQVSDGDAITGTTGAIEPAGDMSVTSQLLAVAPIPSSSRRMVNKLRHVPSLLLERVAHLSFSHPFSRRIPAVASTSQGEDEYDDDSLVDQYVTIQGEDAESASLRSDEGEVDGLEDEYQVPIADHERHPDDTPSRRTSDSPSIASDVSSGVAILDVDHDEEEFEISDTEEQGLEIISIEGGLESPFTGSSNLDTIAGHEGGEGYGRTTQEADVLVAAVHHDNSDDAEPNTELPILEQAGEGNHPRWEEIPKGVFFLPAPDPTGSFLKEPELSPLQVVSSLTHFERAGSSTMDSTPILIAGTSTSSPVQSTSFDNRTPYSPMSSRREVVDIQPHSRVRKQLATPLVLHERIFNDASMQIKSPTEVRSLVRPRPPGVPVILTPQGLSGSLLTAIASSSSYGFAGLPSPSPATDANPDLWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H7B4</accession>
    <name>A0A401H7B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1901020</name>
    </gene>
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        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027765365.1"/>
    </dbReference>
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    <dbReference type="STRING" id="139825.A0A401H7B4"/>
    <dbReference type="GeneID" id="38787170"/>
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    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_domain"/>
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    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
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        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="7"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="493"/>
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    </feature>
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            <begin position="337"/>
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            <begin position="144"/>
            <end position="155"/>
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            <begin position="167"/>
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            <begin position="473"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE90253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="493" mass="54473" checksum="176501F48C2C0890" modified="2019-05-08" version="1">MAPVETEYYDLLCVPTDVNDTDLKKAYRKQAIKYHPDKNRSPDAEEKFKDISKAYQVLSDPNLRTVYDKNGAKMLDKEGGVGMEDAAGFFANVFGGERFNDYIGEISLMKEMTSVATTMMTEEEKAEMEKDMNEAAGNPASVQATPASSGAATPAVPQPQGGAMPTNGHSATVSPAPGSTTEPEASKSPTSSQLNLKDQRDRDTHNKKRSKLTPEQKKKLQEIDDERRKNMQERVSTLSTKLIERLRPFVDAKRPGDKDDPETQAFEDKMRREAEDMKLESFGVELLHTIGNVYIMKATSFLKSRKFLGIPGFFSRLKEKGAVAKDAWGVIGSAIGVQQVMQEMEKLQARGELREEELRALEEDVTGKIMLASWRGTRFEVTQVLREVVDNVLKDPKASDVVLYNRAKGLLLAGAIFKSTVPDESDEDRRELERMVAEAAAGKSKHQQLQAQARAAARAKRHAEAAAQGASTPKERENIGLNEKADAAQEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4Q7</accession>
    <name>A0A401G4Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0100400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608081.1">
        <property type="nucleotide sequence ID" value="XM_027752280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4Q7"/>
    <dbReference type="GeneID" id="38774085"/>
    <dbReference type="InParanoid" id="A0A401G4Q7"/>
    <dbReference type="OrthoDB" id="2919059at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1251" mass="138211" checksum="CF805CA0CCE317D6" modified="2019-05-08" version="1">MDPLKQYLHILKEDIAWHKFVDDGQKWPSSVRELCGGLLTARRVPLWVTTGPYPAVDPRTEPLLEELQNTFKSHAGSLEDAVFDQQLRGMFGTLLSDCARLRNVISSDILCGSANPKESFLIVMISNVMSSVTADFSIDENVLVALPRYRGGGLNVPTRFMSNSIQVPLLMSVFAEIPDDNSNMDGSDAMVNDPDTDEADSDEESPNPDTEDESSEPSEPPRPVSVTSPMSMSTFLSRCAKPVLIEESDSDSESVYDPPPPAELNAHILVYPPSRELPKRCPLPFLCVAEEDDLPLVMMAILYQRHVWKIHEPVVGVGFSKYDTSISFYIGWLDEDADKEDSLPRVHLGSLGRDGSLDLASLDGAFALCHAALALQGLVAKTCGVSEATVTVVAEEIRDGSVSMWRLDTQEDVNSADSSEGQRDWIEAWAEGLAYKYPATTMTDSKKTATADPKTAQKARKKGSTDSLSVPSMGSSRSTDSTPSSLPMIVIPEEEESKQEGKSQGSKKSAYKPMSCSSFAAAAAKVGNSALIHGYLFDRGVVLSALCKNSVIFSLYEIHAGDAWPSHWKTLSDIPSVDPSLEPFRRELFAQAQKHHELSAVVPRDVPAEILPLLEGSLSLILAVAKRAQRKARSVIPPSESVWRHDFDSLIFDFFTNALNGTISLYSRSGRSSDASRLQLPDDDRVIPSTERMIYLPKAVDMDETSARNLYSYIGDLLGRARDLEEIAQVQIITHELDWSIYRRRDGYALERLKEDPYRAICDALGTVSIDLPVRRESLAAVQLVATGSPKAPYMGAYEDNESMPRTNALNGTISLYSRSSLSSDAPKLQLPEDNRVILSTERMIHLPKAIAMDQRSARNLYSHIVGGPNSGETYDEMMRQRIGCNEDLLEQARDLEEIAQHQIHNHAFDWSRYRRRHGYALERLKEDPYRAICDALGTVSIDLPVRREFLEGVQLVATGSSKAPYIVGLHESKESLDMPILSGAAPNQLQKRLYSSARALETVPEVDDPDQALPSNLGIPHSTGKGLPPRNPPKTASLPTRDYAITASSVCETDHLYENAEARAYLDENLEAISKRLEVLTAGQRKNAKVKNPVSVLELPVFMMEYKKQDTDIGKGENQHRLACASAATFLDVLGLTKKPVFSGLTNGPRVALAAAWSSDGFIEIFERQTRTMDISTALGAFQFASVLARLAIVYSKDLVDTFDEMSKPLLIKQLNDREFEKPDSKLQWKQPVPPKSERGESEDATRQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4W4</accession>
    <name>A0A401G4W4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0100360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608077.1">
        <property type="nucleotide sequence ID" value="XM_027752276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4W4"/>
    <dbReference type="GeneID" id="38774081"/>
    <dbReference type="InParanoid" id="A0A401G4W4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="233" mass="26260" checksum="F108C59F1C6E9B30" modified="2019-05-08" version="1">MLLLNLRGRPSPVPPKRLISTRLPQRHISHPELNLPSMNASVILHKYTFTEALLRIEIFTEPFNLILWKAWAVWMHVLLVFMVQAQSEAASVEIILPLPRDIPVLAQVEIHLATARTVEGGRRMIPRIADHLPVVIPRGFTARVLYDDPTVCEDFGLGHPLDGLPDIGNLRLCVKTLHNVARELYNVMHGIIGRRELANGTLRWLQIVVEELEVAFGLVACPPPITSFQLLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G589</accession>
    <name>A0A401G589_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0101920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608232.1">
        <property type="nucleotide sequence ID" value="XM_027752431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G589"/>
    <dbReference type="GeneID" id="38774236"/>
    <dbReference type="InParanoid" id="A0A401G589"/>
    <dbReference type="OrthoDB" id="4095724at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019039495" evidence="1">
        <location>
            <begin position="19"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="160" mass="16192" checksum="5AC64BA029F38853" modified="2019-05-08" version="1">MLAKVFVYALLPLVAVNALPPRGLYNDVSSYWNEATSEVASGWGAATRAVVSAASSVRMEESATELYESATEVLGPSTSKVYATITTISGTPVVEVTSVGGKAITLATGSASHAKTTTFAGHTFAVNSASSLQGFAVSKPMLVSAAAMLGSICAGALVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5Z6</accession>
    <name>A0A401G5Z6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608501.1">
        <property type="nucleotide sequence ID" value="XM_027752700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5Z6"/>
    <dbReference type="GeneID" id="38774505"/>
    <dbReference type="InParanoid" id="A0A401G5Z6"/>
    <dbReference type="OrthoDB" id="5231159at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="10639" checksum="30BCEB4CF21DAE25" modified="2019-05-08" version="1">MFRVLRGSAMSKADKEGREPTAEYMVKHMSGEPGFSRTHIVRQLSEEFGDDTEEKLEAFERRSAMSGTELTFIESMSRGLNAVGPRLDSKYFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G688</accession>
    <name>A0A401G688_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0105640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608595.1">
        <property type="nucleotide sequence ID" value="XM_027752794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G688"/>
    <dbReference type="STRING" id="139825.A0A401G688"/>
    <dbReference type="GeneID" id="38774599"/>
    <dbReference type="InParanoid" id="A0A401G688"/>
    <dbReference type="OrthoDB" id="3190515at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="975"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="632"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="993" mass="110743" checksum="920A120D2DA151E9" modified="2019-05-08" version="1">MAEAGPSSPTRTFPSAPIAVGTSSASQSKRSRIRFPVDDSLSSLADADSGIASVGLGPPPLVRRSTLTGNAKNPPALARGDGRRRVRSATAHTSFDGQSRSQKAGDMGPPPSKILSTTSRKGGRKERELQGNVFSDGSTGDSHSVAFSDEYDLSREDPRILEEVERALKLKARREARMKASQSISQPRTDMTSSYPTQTSPARASIQIPPPVMTQGDFVVESDVDFSPSVGTIPLHPVPFSHDGGATLDWAGSASEDEKPEKRWALHMNRRKTKDRSSGPSSRTVVEKQDSLFADKLTLIKNKAKSDTLRKAAITSNQLRRRYSILLTPSPAVPVSILDVARWYDKQEPTMKASLEKAEPLTWLKHLWDKGGRKTLRSPRTLSAKIIEEYVKAHTTPQAMETIPEDEIAPEASSIMVSYPESKSPTSTSILEPSISRNRSSYDTQVSFEPVVDSGRDSLGSRPSSEGFTRYWRQSLPNGTDSTRSSIYSNMFSGVSPTNSRLHLRDITKRVRRRGHGSEEALSSAQESISGQSASEDGHGRTGQAPDVSVPELRTQDDSATAAEQRSALHVASVSVDQSQLTEIPAENSWQRDDAEEPTAKREDFSAQDVSSSIPKNARCIRKRLSLPSSGLRLLREHEKRQREEVDEENEKREYERKAQILEDTVSHNSRTRRLLQRVATCIREYDSVQSSLSSVLGMPYPKVPHEMLEAFTYDPCAVTGVTRSLKGWRAVEDIHDRIHRQRKTLRTFGPAFSTDSISSSPGSTPRNIFDDPIASLMQSLKELEKHRQLIVRQAEKVIETLAGVKNVHSDVKREYNETLAHTSLVYPELSQIAVLEGNYRNHYQQFWDLSLDALTLLLDTVTPFWRNYGKVIGEDVQDFLIIPWYRNEFTGEPKRYPIKAFPQRSFRHWIGLTCLSFLSCCITLLQARAAVTLTVNCNLPWITHSGLRYLFFPLYLIGLLIQWCAVLVEGSIVVAQWGVVVWWMGWAVNIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6W2</accession>
    <name>A0A401G6W2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0107880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608819.1">
        <property type="nucleotide sequence ID" value="XM_027753018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6W2"/>
    <dbReference type="STRING" id="139825.A0A401G6W2"/>
    <dbReference type="GeneID" id="38774823"/>
    <dbReference type="InParanoid" id="A0A401G6W2"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="131"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="375" mass="41930" checksum="067FFAAF0C39B54A" modified="2019-05-08" version="1">MSNMFCTLFSRRPKENLTPAQKRMYALERLDNYRTLARLTATRSRYTLTSSDLVSAELQVELAQLGQFAELAYAWLDPEFVFANVDVLSRTNFPFEGYDALQEATLISSFRGVVADVPALVIYRGRTRQLVVGFSGTASLRQGLYDVHANMKAHPSGPACAVHSGFWKMYLGCKAQAFEGVRKGLREHEVIELVVTGHSMGAALAFLFALDVLTADPPLQPGLRVKVAAFGSPRFGNEALSGRWQEIVEAYMAANGENAVTDYLVKAYNDGIPSLPPSIFGYAHLARTALYFYHGQLFHTPVSQREHGVFNVAGDALDPARVPEHPRGGHNYYNGRDWEKIIRRMRWLKQVMETGSGEWEKGYISQVAQAERVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G780</accession>
    <name>A0A401G780_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0109120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608943.1">
        <property type="nucleotide sequence ID" value="XM_027753142.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G780">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G780"/>
    <dbReference type="GeneID" id="38774947"/>
    <dbReference type="InParanoid" id="A0A401G780"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="92"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="5">
        <location>
            <begin position="672"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1357" mass="150684" checksum="AB5DCC7EC59D2856" modified="2019-05-08" version="1">MNPFAPSSSTNLFGSVYGKSKRTQSLAKPVPVLDLPALQSASRALQEQHVKDTQIIPDLGDLLASPNGKSSSSYSVFPDDYRVPFQKRRLIGIPEGLFKYYTITNVPSHMGLMPEIERVWVTIDHSLFLWDYIDVHVLDSFADQPDVITDVALVKPRPGIFIDEITYLLVLCTPVSVVLIGLSVKTVTGPNNRTHKVLKLYATDMTISCDVEMSSVIGTQEGRIFMCGVQDGCLYELHYQEKEGWFGKRVQIINHSVGGVQTLIPRLSAPKLEDRIISAVSDSARGCFYTLTAKNTIAVYRPSGDKSIQHVQTISNLYKGAQDIAPGSPALTLQNFQIIALHVVDPSESKSGVQLMAITTKGVRLFFAPTISASNYGGLGASAQGAIKLMQLIHVRLPPPNLLHPDEQSNAYHSTSAVGYGSSHTPQSTARPYMVSGLESSCYDVGLTIAAQPGDVDGTDYILCMSPDLTRIGSLGQYRGPSPLEPTPQYASTSYGTIPGPPRPPLIESATLLSIPGRTWAMATVPRRAPSSVKSGDARPTATNELAYQFSDSTRQFMILTNVGLTILSKRRAVDQLKDVIEESQVEGNAQPLMEFRDSYGRDQTCAMLLAVASGNTFLDIGEDSKLGTISTVSPELAVVAKQAFYEIGQRPTWAERATYGTNEGFGTAIYSGRREGFALYFARLVRPFWKAKLMRTGRNGAQELEIHEDILVTAQKNLYALKELLDTNPHLFHSAPGDHTSARSSTASEQEAWKAEQSSVSELLSLLGRTIEAISFVLLLSDHQLGDIVKHCDSETRQMVTSMTFEDLITSQNGVTGSRALVNVIINQQIGQQISVDTISEVLQQRCGSFCSTDDVMLYKAIENVRRAVETRSFAERQALLSDSLRLFMKGARILEFEKLREVCGDYQQLNYAKGAIQLPLHCAVTFDTDGKGKEYWLAGCPANDRRAKYWERRMNCYDLVLDSLSVFEERGIAAKSDAQAVTTDDPDTVRIHAYELAFASDDEIFHSTLYDWLIKRGMADELLEMRPVYLEAHLRREPITVEKFQLLWQFYVKDGQPLRAAEVLGALAESTDFNLPLEARVEYLTLAVANAKSHPISVGGRYETALAFLTDLEERLEVAQVQLELCTTLQPHMHESPEAEARIKLLAKGLMTITELYQLYAIPFDLLPMQLLILHVSGHRDENVVRPIWNKIIEEALDGVEPKVGADKIMAKVVPLGQRFYPSESAFPLRHIASLLVRFNLAHKGTVAYGWAPRILVQCGVPHSEIWDILNEMYESQIPPFNDQANVQAISSDIAVLLTDWVEEAIRPTSLAARDEFPVFRVDQAVDQYLAELEPRRTETKAAYENVKRQLRRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G798</accession>
    <name>A0A401G798_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0109270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608958.1">
        <property type="nucleotide sequence ID" value="XM_027753157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G798"/>
    <dbReference type="GeneID" id="38774962"/>
    <dbReference type="InParanoid" id="A0A401G798"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="49" mass="5791" checksum="5200E61764C33814" modified="2019-05-08" version="1">MWALPSLDRMEMQKRMDAGNWRSVSEEWSGESKKYNSCNQPVVQQQSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7K1</accession>
    <name>A0A401G7K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiosulfate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0110290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609059.1">
        <property type="nucleotide sequence ID" value="XM_027753258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7K1"/>
    <dbReference type="FunCoup" id="A0A401G7K1">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7K1"/>
    <dbReference type="GeneID" id="38775063"/>
    <dbReference type="InParanoid" id="A0A401G7K1"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="78"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="180" mass="20144" checksum="F99A388EA0BAFCA4" modified="2019-05-08" version="1">MFSRISISRCAVLAHAATRSRPLARPMLAAQQIVRFESQKAADDEEKKKFLETLNDVLRDWDAKILGYNDVKPKSLEPSSDFYIIDVREPDEVRLGSIPSSVNLPLSVLAGALHLNPAAFKALYGFDKPKQDQEIIFYCRSGKRSGSACDIAKRNGFKNLANYKGSWLDWVKKEGITPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7V6</accession>
    <name>A0A401G7V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0111340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609164.1">
        <property type="nucleotide sequence ID" value="XM_027753363.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401G7V6">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7V6"/>
    <dbReference type="GeneID" id="38775168"/>
    <dbReference type="InParanoid" id="A0A401G7V6"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="608"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1296"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1361" mass="150732" checksum="9A209DAEEAB341EA" modified="2019-05-08" version="1">MLELLQSYTGSPTTTLYSLALPREILLLYPSGDSVVILNARTLVFVRALAFWEAFPGTRHRKDPIQCLTIDPGMKLAVASMGSRVAAWSHSGVHSDAWRLHSTLLLPEDDPVTAIDCKSGLLAVGTRSSLSVYTLILENDLLTWSQKWKCFIATPACVRFSPSLMYIAASFLHNNIVRIYSTASGRQTQAIPHPRPLTDIVWRRPQATSRDDPILYTTTSDGTLRIFLPVLDVPQYMQLHAALDAASAFPFPTAPTTSSIFPLDRDAVSSALTEVLAGAQSESEDARSRRVREIAEEGWDLFLRVLADGSLVVQAVANINRRPPTLLKQFTLLRSPPGLLLGNRPPTQLFIIPAPSGGSTPTLTLVTAAPLASYTLSPLPFFDARADGLRLLARAVEEETGAQTLREIVRFVRTPEGEGVGVLWEDGSGRTWAVGTGGKEKGMSLVRRGIWKADAFGSADQLVVLDSGRSFVTYASSTNLLTLHTLDDAPATLTVPPLLSLFSLFSPGSNFALIGITPSHEVLLFTLVPLSLYSRRVLPLGINTSLKVILPVDPMAWSGPYARAASTEEHDVLLSVSVDGELAFWVPGEEVTGMVSVAAVNGVRNGKDKGNGWRCTGRVKTGRRGLSMAGCSSAKKSVLIVPGKDGQELTIWDSKESEFASGLEYREIFDSSDPIQDLDWTATPDAQSILAVGFAHRVEVLCQQRMTYFDETPAWGRCWTIDVGSMIPHPINDSIWLARGALLVGAGHFMALFGQPQPVLESSASEESLFEHVARYNGPLEDYHPQMVLQCLLWEKVELVKKIIVNLARNLESGKDVEEWRCVPFEEFFQKDEMARAESVHKQQYSLLFSVPETREVSDDDQFSRSLVKQLIERLEEQPLPHLTSNEHASLLVLIQATLEIQEQRRALDANGLRYLISTRSFVIQNRRLSLPNTPASNGNGALAGRIRPRARLRYRDMIWAFHSESQDLLLSTSVAACGGKMTWTDARALGVFIWMHSGEPMRAHMEVIARNQYMAGDNRDPTECSLFYFALGKGKLVHALWRQAAWHREQNVMLKFLNNDFTQPRWQTAALKNAFALLSKRRFEYAAAFFLLGGSLKDAVNVCIKNLSDFQLAVALARVVEQDDDGPIFQDILINTVVPLAFKEGNRWLASWAFWLLHRRDLAVRILVTPLQDIASVLDVRLTEIGDPHYDDPSLALLFSQLKFKTLQTAKGTSEISGRTEFNFVLQIARVFCRMGCHVLALDLVRTWSFHRPSTVVHDGRPLRRPPSPISTRFALEPALRRKSSIFIDMDVTTAPPTRRASPTPQVTNGLPAVGLPSTVSGEEMKEESDFIARKAGLGSLMKSAKQDVQVPEFSMDAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G874</accession>
    <name>A0A401G874_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0112470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609275.1">
        <property type="nucleotide sequence ID" value="XM_027753474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G874"/>
    <dbReference type="STRING" id="139825.A0A401G874"/>
    <dbReference type="GeneID" id="38775279"/>
    <dbReference type="InParanoid" id="A0A401G874"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="767"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="850" mass="90730" checksum="B39F655201AEB064" modified="2019-05-08" version="1">MAQTEVEGSKVSTKKSGKRKVKESSDEKEVPTVKPPKKKRAMKEYKSKEFIESEDETPALPSNLPAKTAGDSNDGVAKTNAPAKPVKQTTRMTATPHVAPKGKAKGKAKATAKGKATAKGKATAKGKAKVTVSQKDMWKKMSTRVSDFMWAHATDSLVPCVGCQEKEWPCKLNTANFGRCLECAARGVSCSIAPRNTDGVPLRGNSHTAQREFQEMCAVLVVEGKPLPTSPPPYDVKVDSDEPDGAEPMVMGASKRKPPKKTKMRNAAASSSKVKGGEEVEAMKQKATVTPYEANAEGEALVEKSSKSKRATKSATATGAVALSNSGEVTNSGEVSNSGAPAKSGVVAKPGEGKKSGPKAKPVRSQNSGAQDGGEVTRTSVREPDEVPPAKSVVKEGGQTTRVAMGGRSGPMVPVITRKAKASAPKAAAKMPLAEGDGMEEAARLAMEAVQAMAFQTGPAAPPQASSSKRMLTPVADEPEDAPEYQAEVAEDERASLERPHDDRQRSLLMPHETSAGAAEVAQEVTPSLEISKASKGAKSSTLAKAGHLDEGRRPAKRGTPLDRNAAKKEAEAKRDAKANRLRAVPLTSKAPHLRDVQRVSTGSPAPVNEGDTPSGEETSQSSNDDCANCAELRQEFLAHKDGMEVQFQERMADLNTVKAEITTALQRINPPSAFQENARSIREEVKLAMEEFRRPVTIELQESMKLAVADLVAKRHCLPELKEKVNRLEQGANQMVSQADVDKLQGELADLRHSMELQAARSDSMEKELRSSAAEAIAQASKLEMELALAKEDSMAVATSALDEAKKVGKEVATAREETSLVAKSLDAFREKVDSAMVFTAFRPDRHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8F0</accession>
    <name>A0A401G8F0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0113340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609358.1">
        <property type="nucleotide sequence ID" value="XM_027753557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8F0"/>
    <dbReference type="STRING" id="139825.A0A401G8F0"/>
    <dbReference type="GeneID" id="38775362"/>
    <dbReference type="InParanoid" id="A0A401G8F0"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="57"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="218"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="615" mass="67397" checksum="6BD6A1B6D4510C40" modified="2019-05-08" version="1">MAPKQPCAKYQYVVTPAGPKILPVPDVHSKDEESPADYNTGGYLQVKLQDSFKNGQYVVLRKLGWGHFSTVWLVKDTQANRHSALKVVKSAGRYAETARDEIKLLGEVMEANHAHVGREHVVSFLDSFQHCGPEDTHVCIVFEPLGENLLALIERHKKTGVAPALVKVVAKQILLGLEYLHDECKLVHTDIKPENIMISIPDVESHIQAELEVIPSPTSRKVGVPPKQLGRTGVIIPRRPGGRERHVHIFDSQPLSSPSSYSPGLVSASPVTRPDMHMSRKGSTHSVVRLNAALKKGKQKSSSSDVSDSLSGSSGSGSAFASSSFITSMSNETMATSVGSVVSGLNKISIVSSPGIYSCLCEREAGIVKGTAVVTDSLDERPQQLKPSTGPSLLSQTAPHNLTSEPVDTPMCPTCCSSLSQPPSRPASPPSNAVPSLPISVKIADLGNATPIQKHFAEDIQTRQYRAPEVILGRTDWGTTADIWSAACVIFELLTAEYLFDPQSQGDVFGKDDDHMAQIIELMGDFSPDVKFGGRFSRELFDSTGALRYIRSLKPWPLKRVMAEKYLWTEENSEAFCAFLEPMLIIDYRERMQARDLIHHPWLEVDLMSDDLCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8K4</accession>
    <name>A0A401G8K4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0113950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609419.1">
        <property type="nucleotide sequence ID" value="XM_027753618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8K4"/>
    <dbReference type="STRING" id="139825.A0A401G8K4"/>
    <dbReference type="GeneID" id="38775423"/>
    <dbReference type="InParanoid" id="A0A401G8K4"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="116" mass="12942" checksum="B80DF4089C3142B8" modified="2019-05-08" version="1">MVSTEVIMARGMDFKGVREVINYDFLQGVQICVHRIGRTGHAGGKEKTVTYFSDQVAPFLKTIANVLLQSGSPVPEWILKLPEPSKIKWSEMGKVGRAEAVTRASWVGRQDAIRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9D3</accession>
    <name>A0A401G9D3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0116650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609685.1">
        <property type="nucleotide sequence ID" value="XM_027753884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9D3"/>
    <dbReference type="FunCoup" id="A0A401G9D3">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9D3"/>
    <dbReference type="GeneID" id="38775689"/>
    <dbReference type="InParanoid" id="A0A401G9D3"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="274" mass="29469" checksum="7A0CD29A1FD4FC08" modified="2019-05-08" version="1">MAATDDAPDLDGALYALMRAFAMIIVSEVGDKTFLIAAILAMRQPRLVVFAGAFASLVVMSILSAALGHVLPTLIPRKWTQACAALMFFVFGARMLQEGRAMQGGSDKMREEMKEAEEEIELDEAGHDGDVVPLEAVEEGGRPQRESNGSARPARPPQTKALKEATRNFFSLFLGPVFVQAFVLTFLGEWGDRSQIATIGLAAAHNVYLVALGTIIGHSCCTAVAVTAGRYVSTKVSVKHVTLAGSALFLIFGISYLYEAFLSIDPDDADFHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9V1</accession>
    <name>A0A401G9V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0201420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609858.1">
        <property type="nucleotide sequence ID" value="XM_027754057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9V1"/>
    <dbReference type="STRING" id="139825.A0A401G9V1"/>
    <dbReference type="GeneID" id="38775862"/>
    <dbReference type="InParanoid" id="A0A401G9V1"/>
    <dbReference type="OrthoDB" id="2672960at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="312" mass="35735" checksum="62A1655FF60E402D" modified="2019-05-08" version="1">MARILVNPTVAECPDYASATYAVTRAPLINANTTEDEAVQLLKNIWKAGNDADKAAWEQQVNDDATDVADQIRLAEEAEVQRLDTLRQEEELSHKEELKKNKEKYLLIPDRDAPTIAPILPATYAVRKMKKGLYTEMHYYTNKGLDEALSGSSTIDDEAMILLQNPNGTTSWVPAASARDSRGVTEDKDLTWEDFCQAAPRMIRAMEEASWPEDRVAMLAKFWGNLQIHELRSSRDPLDQKTLLVYQAEQRKAWHLAIPSPQGAWNISRINDEIMRKVKERVYWEARNLKDNERDFRRPTDGRIHIWSRCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA15</accession>
    <name>A0A401GA15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0202070</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609923.1">
        <property type="nucleotide sequence ID" value="XM_027754122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA15"/>
    <dbReference type="FunCoup" id="A0A401GA15">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA15"/>
    <dbReference type="GeneID" id="38775927"/>
    <dbReference type="InParanoid" id="A0A401GA15"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="646"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="337"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="406"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="475"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="840"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="895"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE79010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="933" mass="104572" checksum="698C091698AA5D87" modified="2019-05-08" version="1">MSVRVRRAASPPPGLPHATPRFPHPRSEHLDADERREAASRGFVPSRKAHSSGGVNLTAAEWKLLAVITIVAMVVRLFRISKPDSVVFDEVHFGRFAAKYIKSQYFVDVHPPLAKLLITLAGFIFGFDGNFDFKDIGKPYEHTPYVAMRLVPGLLGVATVPLSYLTLRALDCRATTALLASLFITFENGLITQSRHILLDSPLIFFTALTVFLWTGFCNEDKHEPFTDRWWTWLTLSGLSLGAVVSCKWVGLFTIATVGLGTLKQLWLLLGDLRVTPKQFFRHFAARALCLIAVPVLFYMFMFWIHFLILQNPGDGDGFMSSEFQHTLNGRGMADTFADIGVGSTVTIRHVNTQGGYLHSHAHVYPGGSKQQQVTLYPHRDQNNDWLLLNATAEADPVFDWQNEPLHYITPGMRIKLRHLSTDKALHSHDFRPPVSDVDFQNEVSAYGMAGFAGDANDDWFLEIEKGDRRDKESGKRVRTLRTQFRLRHAMTGCYLFSHKVKLPEWGFEQQEVTCNKNAVKPNSLWVIETAAHPQLPANAPKVNYRLPGFVSKFVELQQVMWMTNAGLTDRHMFDSRPDAWPRLRRGINFWVKDHRQIYLLGNPMVWWLSTAAVIGYAAVRGFLILRAKRGFKDFENTKVVKYDTLCGFLFVGWFLHYFPFYLMGRQLFLHHYFPALYFAILLSCVVFDLVTSALRPKIRLQIAAVLLIIAIWNFVYFSPLAYGNSWTKAKCHSAQWMKTWDFACEEFYDNYSQYDSLIAATPQKSQASAATIGGEPGGRAAVVVENNVEPNVEAAGADSADTTVAVGQAEPGRDIFAGVPHEDLKSQPHVRPAAEEVVSEEKEISSVIGQEPTTALEAETAEESPELVAGDHYAEDAPLVGDVPTPEEVAGEPEPAHRGAEDGKTQGALLEDEAEAERARVELFPDEAEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAF3</accession>
    <name>A0A401GAF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Set1 complex component swd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0203240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610040.1">
        <property type="nucleotide sequence ID" value="XM_027754239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAF3"/>
    <dbReference type="FunCoup" id="A0A401GAF3">
        <property type="interactions" value="902"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAF3"/>
    <dbReference type="GeneID" id="38776044"/>
    <dbReference type="InParanoid" id="A0A401GAF3"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="446" mass="50397" checksum="AFD0A8BAFF52096A" modified="2019-05-08" version="1">MNGTLSNPFNITYPTAVQSSLDAYASFARFDPSGRFVAAGRSDGSAVIWDLDTKAAIRHLEGHVKGVTSVDWSRNSRYVLTSSKDWNVIIWDLASDTEPVRRQVLRFDAPVVSASFHPRNSKILLVLLGSGEAYVVDLRREYRGRFELCEVQDDSDEEGQMSKQRSAMTVARFDPSGKHVFIGTTSGSILVFNTRTKSMVARHKISGAGIMRGLDFTKSGRRLVTNSSDRTLRQFNVPSYAPPTADREYIEQELEPTHRFNDPINKTAWHAMSYSPDGEWLAGGAADNAAHKIYIWDISNEGQFASALDGGREPLLYLHWHPHKPAIASTTNQGNILIWHCPTPERWGAFAGGFEEVDENVEYEEREEEFDIEEESELALRKMKAEEQEVDIDGLTDDKDEVARRNELQRNDEDDEDVAWATEEPDEDISDWRMRIQVEDESDTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAQ7</accession>
    <name>A0A401GAQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0204640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610179.1">
        <property type="nucleotide sequence ID" value="XM_027754378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAQ7"/>
    <dbReference type="GeneID" id="38776183"/>
    <dbReference type="InParanoid" id="A0A401GAQ7"/>
    <dbReference type="OrthoDB" id="3197626at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="352" mass="39215" checksum="3AD2AD92545D4F71" modified="2019-05-08" version="1">MVDWSSQEEIERDTTAYTNLVFTLFGLYIWELFQTSNFEWSLITRKRDFAWPLSQYCLLWALIGLLISFSVIKHVNCQALYTFNSWTGNMAILCASTSLMLRTIALWERKLKIVIPLGILCLAHWALLWRGMFVIHAVYDTATEACEVTYTNHVFLNISFFATMVFDLAILLLTIAALVPLTSRSSLVRMLFHDGLVYFLVTFLFNSVPAILAVINLNPMMNIIATIPAATFSAIAACRAVIRLQEFAHGDIYVHNASQLPSPGGRTGNMHFGRMSGVGVPSATAVRLGGAGGLKAQPYVFARPEVHVTTDQFVMEDFGESVADVEEHKRSPTLDTDDEKLSPSVNTAEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAW3</accession>
    <name>A0A401GAW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0205030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610218.1">
        <property type="nucleotide sequence ID" value="XM_027754417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAW3"/>
    <dbReference type="FunCoup" id="A0A401GAW3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAW3"/>
    <dbReference type="GeneID" id="38776222"/>
    <dbReference type="InParanoid" id="A0A401GAW3"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="568" mass="61396" checksum="34F02252BF9C43E6" modified="2019-05-08" version="1">MSREPSETRPLLEDRPATLDSYSALVDGSDHSPTPIEYSPPNKVSKVDLAWILAGLWSAVFLGALDGTIVATLLAPIGSYFNESNRSSYIGTSYLLSVCCFTPLYGRLSDILGRRGAMLLALTLFGSGTFLCGLAPSMDALIAARAIAGMGGGGVMTVSSVAVTDLIPLRQRGLYQGMTNILFGLGAGLGGPLGGWLNDTFGWRSAFLLQMPILIFSFLLVTAKVRIKLPDEVQNQSVRAKLRRIDVFGSLTLVGTVGCLLLGLSLKSTEELPWSHPLIWGLLAASVVWCALFILVETRFSPYPVMPMRLVKERTPLAVSLSCFFGSVAAFSMLYNVPLYFSAVRLNSSTDAGLHLLPHSVAISTGSVFAGWVMRKTGKLYMLTLFSSAMTLVSCGLIVFWSDITPAFHLWFDIVPQGFGMASVITTTLIAMIASVSREDVAVATGITYLFRTTGQVLGVSLSGALLQSILTKKLRERIHGPDAMEIIEQIRHSTSIIPDLSPHLRKAAVDSYADALRIVFICQLAANFLCFLCCIPIQDNPLPGSHEEQEAVYRNRKNTVSSSTSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB60</accession>
    <name>A0A401GB60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0206020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610317.1">
        <property type="nucleotide sequence ID" value="XM_027754516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB60"/>
    <dbReference type="GeneID" id="38776321"/>
    <dbReference type="InParanoid" id="A0A401GB60"/>
    <dbReference type="OrthoDB" id="2844016at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019349718" description="Cell wall protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="21709" checksum="1555427BD487B0F8" modified="2019-05-08" version="1">MFALALSSLALTAVSYALPMLTTRQSDPCAGLGIASFPTEYNFTLAAWNWTLPNANDTGAPLVIGQAGAVDGESFGVLSTWATYSYADWTTFSLIDGALIPYSADGAASNGVDANIFSGEELLWVFTVNPPPPAEIYCGVADPDPAGGYQYAALAVNGSTDGFSLCLLGEPPYVQNNIVYRASPNNTDGYDYESCYGVRVQILPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC99</accession>
    <name>A0A401GC99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0210190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610731.1">
        <property type="nucleotide sequence ID" value="XM_027754930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC99"/>
    <dbReference type="STRING" id="139825.A0A401GC99"/>
    <dbReference type="GeneID" id="38776735"/>
    <dbReference type="InParanoid" id="A0A401GC99"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="170" mass="18622" checksum="D3E9D453A85F6513" modified="2019-05-08" version="1">MADPYISRKEARSSWRPYNALMSPGLKRAREPFRIRNAVTGILIASFAVGVWAYSISAVKQDVFDDVDEEARSLRSARIKSLEDQEAVRTLEKEATRGVVAVEPPIAPQVQEQTAPTLPIPSTSGGLATAGRGLLPMLLDQQFPRLLDPSSKTLVWGAPPVDRIGKMKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCA6</accession>
    <name>A0A401GCA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0210100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610722.1">
        <property type="nucleotide sequence ID" value="XM_027754921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCA6"/>
    <dbReference type="STRING" id="139825.A0A401GCA6"/>
    <dbReference type="GeneID" id="38776726"/>
    <dbReference type="InParanoid" id="A0A401GCA6"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="293"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="532" mass="58393" checksum="A7A6104B597336E8" modified="2019-05-08" version="1">MDSLAFDSYTSYSDSSAPRTPSPRTSIASDDMQSFPSPPNYKHPLDVHIHRNIFDHSDEHGIAPETHTLEAAHMWSSPYPGSYAAPGSRGSLLEELYEPGIPDDSLQNDVYHHQSSDPTLHGTNWYHLTQAHPMSSMRHAHDVAMTRRATFPYVRQDRGESFYTPSPPFGGSDHDSITSSPYGSRPGTVYSEPLSIHGSPNLGMSESLHAHQLDEPFAHTVSMTNSPHPHFHDYHLDGIKTEEAAPVIVPSQTAYCRPTSAGMLPLPCLSPHAGLLVQHTDDAASKETQYLRRRCFNCHTTEPPSWRRSTLNPGKIVCNKCGLYERTHLRPRPLRFDELRAGHKSRKPPKVAGSPKQGKMTHMVKKEPREGEMEGMIPRRSSVSSLSSSVSGGTSSDWDDNVSVYSSGSAPPSSMGSPVPSGFSMSRDCNSQSPPLPRDGGIRLPNAPLSDIASLQSHQPLHPLSSPRKSATAPMPYIQSQVQSDFYTRRGSLPPPFDLQRSSIPEVTGWQSVPLADLAPAKSMKPRKAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDI4</accession>
    <name>A0A401GDI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase family Tnp2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0214370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611140.1">
        <property type="nucleotide sequence ID" value="XM_027755339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDI4"/>
    <dbReference type="GeneID" id="38777144"/>
    <dbReference type="InParanoid" id="A0A401GDI4"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="58891" checksum="5551ECAD8BAE4E16" modified="2019-05-08" version="1">MPASKRQYQCDCEKHCGGRQKVVSRATYYGHAEFRAKTSQTFADFVADLSGTRIFSHAASWPSEGNTSQLRGRKRARVENEIYEMSEQMESSTIAPSFDELPGPDMDCESPGLGPSTETSEFTPTCTLHLAHDHITLSDVDEHEDEDMDPGSIAATRGSEDAASSSQTRDDTRSGLGPETELEADRTATIEEIKIAEEFIRLLKQASLETSGLDANTIHRLHHPIEAPLDIDDPDLLLSIEIFLSVTNTSQATYTAVRGAILHRYPENTILTFDQVKSKIAELSGVVPIIQDMCVNTCLAYTGPFAELDQCPTCGEPRYDTTSNGKKRIARQEFHTIPVGPQLQALWRSREGATAMRHRSRRTHEILERLREHNNQLYEYDDVYHGSAYLKAVLENQISTDDMVLLMSIDGAQLYESKASDCWIYIWVVLDLAPELRYKKKHVLPGGFIPGPHKPKNLDSFLFPGLGHLMALQIADTLQDQIHLFHPRKDRTHPVGSFLRADHHYLCQVMRSHKQSPTQTMKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDY3</accession>
    <name>A0A401GDY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611311.1">
        <property type="nucleotide sequence ID" value="XM_027755510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDY3"/>
    <dbReference type="STRING" id="139825.A0A401GDY3"/>
    <dbReference type="GeneID" id="38777315"/>
    <dbReference type="InParanoid" id="A0A401GDY3"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56522" checksum="C8DD95DB1D4BEFDA" modified="2019-05-08" version="1">MVAVTELAAPARSPPAVGTCIDNGTLELIEILGYRGYGVIYCTVNIFSPDTSQGAPKTIKIEEVFELEEFNAIFTGKGRLIQPTPENKPKSTMTIMNFVQVLFGDELKALKGNCSVKWPYSRKRNTEHQCQLHLREMMLHQLASAHPNVITLHCIIEDFNYTYLVVDYCPDGDLFTQILHNPRFQAHHDREDEHRVLHGPAHVDDTPSSPMSRIGPRSSSGRVGRTQDPMHFLSTLLPISEEVNLLLSQILEVDWRRRIMLREMRLSIVDTDSESSEEEPEPEPEPKELPEVQDESMWSNDSESEMAFATQSVMDKSSWAYLESYTKRDSYAQSMSPSPDSPLFTTMKLFEMMNTPSAASPYLILSSSPSIPSLPVIPEGGESLQPEESQRPKALTLCNVRSIRTWPTLHAIPDVNPAPALFSEELIPRVQDSSSLYIPGYWIVRSAPGRKMMPEDDLLPVQWQCKSSSLTAVAFSTNIVDRPILLSSMITSDPLTSRSRIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEC9</accession>
    <name>A0A401GEC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">SCP_0302450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEC9"/>
    <dbReference type="FunCoup" id="A0A401GEC9">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GEC9"/>
    <dbReference type="InParanoid" id="A0A401GEC9"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE80530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="297" mass="32290" checksum="F3297AB6B78DA452" modified="2019-05-08" version="1">MSSKLPSVLSATDEEIQLLLAAQAHIGSKNCDKQMLPYVWKRRVDGIHIINIGKTWEKLVFAARIIAAIENPNDVCVISARPYGHRAVLKYAANTGAQAIAGRFTPGSFTNYITRSFKEPRLIVVTDPRVDHQAIREASYVNIPVIAFCDTDAPLKYVDVAIPTNNKSRHSIGLMWWLLAREVLRLRGTIPRTADGWNVMVDMFFYRDPEEVEKQQQEEAQAKAAAAGVEPEPAGVSEWDVTSAPAAGGINPGLVAGDSGTLDWAAEPAAGTTTDWAAEPTGPSTWGADPVVPSGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF03</accession>
    <name>A0A401GF03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0304020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611596.1">
        <property type="nucleotide sequence ID" value="XM_027755795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF03"/>
    <dbReference type="FunCoup" id="A0A401GF03">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GF03"/>
    <dbReference type="GeneID" id="38777600"/>
    <dbReference type="InParanoid" id="A0A401GF03"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="443"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="783"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="889"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1078"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1183"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="898"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1083"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1183"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE80683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1220" mass="134778" checksum="B534A7D6B7034C55" modified="2019-05-08" version="1">MSEPELLPYMSGTNEEFDLPRWHTQTLHDGLSSSAQAAQSAAQASYIYAQGPSLPPMQATAHRLAPMHQQSPTGSSRQPRITQLLDEDQPFVMNSLPYTSSSLARSVSLGGGASAAPTSRGRRHQQDDLEGAFHVDEESVQRQASQAMQQSSHSLYPPNLAYHPAQSSVGSAANNSASAAPAADSYHDPYFTTGQQPRRSQTQHDQNQYSSSTPISYPYSPSLEQQGAYMPGTYQAHSRSHSQSKGEAMTPPVPAASAYSSQNVLQTSNVYSPVYPMETTSPAPSSSQNLATQRVPRQSSVSQPATPLSFGHTSQKAQQAQAQYFAQEHQPMTVEVPPPKRRASGLRRVRDHRDLRPYVNAQPAGRRMDASGIFLSPLRQLTTNIVETYQICNPQFRYESTHNPRRVLTKPSKPSHNDGFDNDDYDYILYVNDWLGTDEGHKYLILDILGQGTFGQVVKCQDMKTHEVVAVKVVKNKPAYFNQSMMEVTILELLNSQCDPHDEHHILRLRDSFIHKNHLCLVFELLSSNLYELIKQNQFQGLSTQLVKVFTAQLLDAMTVLKEARLIHCDMKPENILLKSLQSPQIKVIDFGSACHERQTVYTYIQSRFYRSPEVLLGIPYTAAIDMWSLGCIAVELFLGLPLFPGTSEYNQITRIVDMLGLPPQYMLDIGKQTGQFFDTYTDVYGQKKYKLKTLEQYSREHNTQEQPGKQYFKASSLREIITQAPMPTFKSSRQAHEAEKELNNRASFIDFCQGLLNMNPIERWSPQQARMHPFITGEKWTKPWTPAGQPNNAVAPPSTSGPDTKRPYGGLVPSQPKGTRAYQDAAAYNQHLAQHQAYTAQAQAASQAAQNVYRNPYITPQTSQQGSTSYSGSQDAATSYAAQQQYTAQPAQATAQRGLTHQSSHGQLNVNTNVGQYAGHPQGGAFPAAASHLSPTAPSNSYYSSARARSNTINNMMDNIPPALARLQHMNQDVIGGRKALTPVLKRDDAIREWERRQSGKAAAAQPYPQLEFLQQQAELAAAQGLTNWGQTGTSRSYHHQPTSNLAHSYHPSTSMVVDEDRRDAILSNVRSAARAEPPANMFSSNSNVIPTPPQAYSSNSTTSGNRYAATYTQPQQTPTSPFDSLDRRTDIGTLYVPMQPDQYGSYSNQAAASAVARQVAPPAQAVPPSFYGAGVVPAGMATNQQRNPFSTADTLPTSQGQVSSKESRRKSGMDLWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFF9</accession>
    <name>A0A401GFF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kynurenine formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0305810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611774.1">
        <property type="nucleotide sequence ID" value="XM_027755973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFF9"/>
    <dbReference type="STRING" id="139825.A0A401GFF9"/>
    <dbReference type="GeneID" id="38777778"/>
    <dbReference type="InParanoid" id="A0A401GFF9"/>
    <dbReference type="OrthoDB" id="7108654at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="24676" checksum="E60E791E9D0FF292" modified="2019-05-08" version="1">MSSPKRAIIDLTHPLVPAGVPACPGHPIYNAELISSLSAGAFANVHALSLGSHTGTHLDAPYHFFMDGAPIHALDLELLAAAPALVVDLRAKPAHAPITWADLTPHAHAMRSGVALLLCTGWSRFYGQENYSDHPWLEPDAARRVLEMGVRVIGMDALSPDEWAAGVDTGMVHRIVLGSGGVIVENLCGLGRLVESGWERPLVSLLPLNLQGCDGSPIRAVAWEGKEESGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGV3</accession>
    <name>A0A401GGV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0310600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612246.1">
        <property type="nucleotide sequence ID" value="XM_027756445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGV3"/>
    <dbReference type="GeneID" id="38778250"/>
    <dbReference type="InParanoid" id="A0A401GGV3"/>
    <dbReference type="OrthoDB" id="2847449at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14029" checksum="BB29641812140F47" modified="2019-05-08" version="1">MAQMVHIAGAETALAMWEQLRTVKEQRGQHGILALCRRFYRMQAKEEDNISNHITQLRQIQEQLHLMGKVVSDEDFRLILATSLPESWDSFLSSYFGAEGTDNVRPQLTSQELIAIILDENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH44</accession>
    <name>A0A401GH44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0312360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612420.1">
        <property type="nucleotide sequence ID" value="XM_027756619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH44"/>
    <dbReference type="STRING" id="139825.A0A401GH44"/>
    <dbReference type="GeneID" id="38778424"/>
    <dbReference type="InParanoid" id="A0A401GH44"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF34">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="147" mass="16758" checksum="958A28716B4FE671" modified="2019-05-08" version="1">MPRTDAIWEVNEDGVSKDMQAFSEQWEEKLEGPLFPALGNLESAPTNSFPRNTTDHPINSQWVFAIQEGSWSQWIGRKATAQIRHNSGSYSTMAPGLNLKIISLNTVYWYKQNFWLYDSNEHQPDPNGIIAYLVQELQEAEDAGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHR4</accession>
    <name>A0A401GHR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0400320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612574.1">
        <property type="nucleotide sequence ID" value="XM_027756773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHR4"/>
    <dbReference type="STRING" id="139825.A0A401GHR4"/>
    <dbReference type="GeneID" id="38778578"/>
    <dbReference type="InParanoid" id="A0A401GHR4"/>
    <dbReference type="OrthoDB" id="2802553at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="463" mass="51398" checksum="39FF83C13D2DC9A5" modified="2019-05-08" version="1">MALQFSLIPLFHRIHSQLRRLMSDQPPQQSWADNFSKEGRGLPVDTVINDYQNRGWVARDLYISVLKFYKHDKGVEHEFLIGTVVNSAGKEVGFILVERQGARIGRGASAKPLNAALGSSGSTAAPPAHDVLFMGRNHGALLNLAGRTARSTVHGSYTVPPEKRADSIASLLAACFVAHEIKEKYDAFETNCYWFAGVVYNLVTGDNININSDSTRTVPIVRDALPEGDIQLEPRSLPQAGGAQSEDNIQVAQDDSQSQVPQRSKTGHFGSLAIVRPADIRADADEIRADFRKKTEEIVSAQKYFGKLPEELASQTARANMADARADTEERLKKEESARAEEERLRAEEERLRADTEERLKKEESARAEEERLRADTEERLRKEADARAVTEERLRKEEERLRKEESARADRLAKENAEMAKKLAQLQEAYTKGAAGASGVTEARTTPPSSRSSMASAFKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHW1</accession>
    <name>A0A401GHW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0400720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612614.1">
        <property type="nucleotide sequence ID" value="XM_027756813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHW1"/>
    <dbReference type="STRING" id="139825.A0A401GHW1"/>
    <dbReference type="GeneID" id="38778618"/>
    <dbReference type="InParanoid" id="A0A401GHW1"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="13">
        <location>
            <begin position="186"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE81701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="378" mass="43165" checksum="E4F729C3B6F9B6D3" modified="2019-05-08" version="1">MEFARPSSPKRIKLVDGGTIETIPKADSVTDGETTILTVVVDVEPTDEAERWIHLLFTWSGKSLALDIAESDRVYDLKATLQSLTDVPPERQKILGLVKGKLPPDEERIGDLKLVSGKKFTLVGTPEGHEIKDPSQLEFLPDVVNDLDIDISANPAAAAAYINDQRNLRKIREHTRKLHINIIHPLREGKRLLVLDIDYTILDTKPLTSGALPPRECARPRLHEFLEAVYPYYDICIWSQTSWVWLETKLVELGMIGGGRNYEISFVLDKTCMFTVFSTREGKQYRHSVKALQIIWNHFKQFNSTNTLHVDDLSRNFALNPRQGLKILAFKDAHTLQATLDRELDKLARYMIHIARTHDDFRNVDHKHWQDVARALPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJ40</accession>
    <name>A0A401GJ40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0405770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613109.1">
        <property type="nucleotide sequence ID" value="XM_027757308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJ40"/>
    <dbReference type="STRING" id="139825.A0A401GJ40"/>
    <dbReference type="GeneID" id="38779113"/>
    <dbReference type="InParanoid" id="A0A401GJ40"/>
    <dbReference type="OrthoDB" id="3268553at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="373"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="614" mass="68449" checksum="B1F018FC6C037634" modified="2019-05-08" version="1">MADPPDDVSQFQSQEPPGPSGRGHRQPRSTTRLEGHLDSIAKSQARRQLYEARKLAQKSMDVPVQSLPQSYTGMLPISLSTLTATEASHEQAFMQQMWQPPDTSTVQEPHNMFMSSTMPEIAHRNLDNFNFESLTFDTLAQAHSYTYNPSTPSIHTAPNQLLLQHDASTAITLDQSFERQELALHVPGSSRPSPDEPGDECAMTTQSDSQLVDQPLPRGMQMISSTPVSLPVHRVSKHGLVHRIPARTASTPKPTQTLVPTARKPHLVRRVTGSRVQRPALGNSAAINTLQRMGTVTAHTQDSPSLTTGAGQNVMSTPTSSNDGCIEALEDDDTSAEDAEDLPPTKKPKKTLRDRSARGLTAERHAIIVVVYQHFKLMLCTEGAYPVSADEDRMIAEAWTIACGEKETPDDLVPTEQERLLVRTRATQVRSALKSLARQLLEKHYGFKQGLTAEIKEYNRALVALLKPKVAFAHIDPHNPTTMCRHPIIAEIITRMWFKDAEDDGVHHPEYFENGLVMLLALVLTEIECAIDEWATGIHRAVELRAPKYKQNYERHLRELRKWERYSSTRSKAPQCMQDDLLKTLRANAGVSDQSNNSAAEEDLSDDDFATYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJG9</accession>
    <name>A0A401GJG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0658 Golgi apparatus membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0406890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613218.1">
        <property type="nucleotide sequence ID" value="XM_027757417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJG9"/>
    <dbReference type="GeneID" id="38779222"/>
    <dbReference type="InParanoid" id="A0A401GJG9"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="349" mass="39377" checksum="CD279DC2A612DC0E" modified="2019-05-08" version="1">MAVEPLLSTRAQRAFVGTIVLQAIVVLVMVAITFAFVEPDVDYTITRYKTLPCYLALFALAEIFELVMTFDALRLRNVIQLIGILLFHMGLTVMAALQIHETRTALVWDSGSVLNTSGPGSLWHKVLPFLVVTPIVIGVAWFVMLYFFRHLYYEFGWAIFHVVGADPKMKTMYQYYQILICLLKFDFFAFTGVTMQLLIIVLRENSAEFGLTVAAIPIVLILLALSGIAVQREIKWLMSISLILMLAAQTYFIYKLVRFYEPSSDQQYLSTRATLTVFTIAASLLLFATFGMGVRCFADFDKGLDKSKLHDVTTGPRYSSYIFDPAGEKHTRKPSYSAGVEMAQRISIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJH6</accession>
    <name>A0A401GJH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTU domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0406980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613227.1">
        <property type="nucleotide sequence ID" value="XM_027757426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJH6"/>
    <dbReference type="FunCoup" id="A0A401GJH6">
        <property type="interactions" value="362"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJH6"/>
    <dbReference type="GeneID" id="38779231"/>
    <dbReference type="InParanoid" id="A0A401GJH6"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="124"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="297" mass="32130" checksum="10767859D2D6191E" modified="2019-05-08" version="1">MAGPKRSKLKKALLPSSHTSTPPNPGMNDDELMDDLMAQLDSRNQAVQAESATVINEMQIQKAADTPPPSKHDSKSRHQARQARKAAALAEKFAPADAEGDARLQKEAADEEKTIKRVCDELGVEIFEISPDGHCLFSAVADQLALISILPPGQAIYTTCRHAAADYMRSHPDDFIPFLPSSGGEDAAGATSDTGLMSQSQLEQYCVSVRDTAAWGGEPEIQALSSAFNVPIYVVQGGNPSVVMHLPSGSPDKGHVADKNVVRISYHRRMYGLGEHYNSLRPKRTLSESVRSMLHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJI1</accession>
    <name>A0A401GJI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0406930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613222.1">
        <property type="nucleotide sequence ID" value="XM_027757421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJI1"/>
    <dbReference type="STRING" id="139825.A0A401GJI1"/>
    <dbReference type="GeneID" id="38779226"/>
    <dbReference type="InParanoid" id="A0A401GJI1"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019451977" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="47466" checksum="5C768CE7DCC88C0F" modified="2019-05-08" version="1">MVAYASLISTVVLFAHYTSGRPTPDSSSGDEVAVSAPYGVIMSDTAELSSQLASESAAASGSGSAEWWSASTTSPSRGYAATSSPYASPAYSDSWKSSAVASADKSMMTEVPSLSSSSGHAISSAVSSHYDKSTAAATASYVSSPAALSSSVWSSSSLASAWYSSATPSYGSGSSNWGGSSYDNCVQQCVASFGSPSSMTTATPPPAAASASSTVASGSTITVIVAPTQGILRYVPFVVNASVGDTVEYVWGANNHTVTKSSELAICNKTADAPFASGEQNTGFTFTQVVNDTQSVFFYCGTPGHCEKGMFGIINPPSIDNANTSVSTMMSAMAANDSSMAAMSSYASQQTSGNAGAAGWGSNIDMSSVPEWAYSSVMENVMYTRMVLAANPSVMQPDGSIDLSAGGSLSWPADITSAVASNTTSSASASVPSSTRSATPASSNVTNGATSTAMSRGVLAVTAIVAAFLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJV0</accession>
    <name>A0A401GJV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0408300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613359.1">
        <property type="nucleotide sequence ID" value="XM_027757558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJV0"/>
    <dbReference type="FunCoup" id="A0A401GJV0">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJV0"/>
    <dbReference type="GeneID" id="38779363"/>
    <dbReference type="InParanoid" id="A0A401GJV0"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE82446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="289" mass="32272" checksum="2FC460C0EC7159AD" modified="2019-05-08" version="1">MPKTQKRRRKVPVTQAASPAHPAPSGSSSNPAATRSLIRRFHVLLKRRAQLQGPIGDTGDAKRALADVEREIEDMGGLGAYQRMSSIGQGKDRGGGSEKVLIEWLQELGVASSAQKEKRVLRLLEVGALRPDNYASCASWIQGNPIDLRSQHPAIAEQDFLLMDEKAHHARWDVISLSLVLNFVPDAKDRGQMLRLAHSMLRPDGFLFLVLPLPCLLNSRYLTPEHFHGLVNAIGLAIVYTRWKEGGKMAYWLLRKSSSNAAERRPDCEAYQKKTVLRQGKRNNFVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKI0</accession>
    <name>A0A401GKI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0410630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613591.1">
        <property type="nucleotide sequence ID" value="XM_027757790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKI0"/>
    <dbReference type="STRING" id="139825.A0A401GKI0"/>
    <dbReference type="GeneID" id="38779595"/>
    <dbReference type="InParanoid" id="A0A401GKI0"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="9">
        <location>
            <begin position="502"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="587"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="72840" checksum="1075D2B98297DBBC" modified="2019-05-08" version="1">MSSRAGGLYGGIQFSSTKAFSSSTPQNAVQTPVTAPVEKTEVTATPSTDQPSTVPPVENASATASISTTFDAGASAKATAGWSASLAFAPIRRNQAQKAKPAAPRLPVGAAMTTAMGAGAPAAISSTAIVFAPPALVEPAKPAETQNQPQGQGWGRKVKPPSMVLDEDVNGFKTQKGGKKKGKGKKHKNAPIVAVWDPTEQYNPMRPNDYNEYKNHKRHEHEERREQLAEKRRAEERKRNRRSNSYSDSYGSGSDDERPRKAGRFDDRDDYRNEEDYDKPRGPGSGPPGQPPPAAMPMNLTGDEAYQRRLAMSAAFRRAASPGPPTSSTTPVTSTEFVIPSSSSARSSVSSTVPQAPVSGLPPSFSPAAADDEDEDVIPGLNVPSAPRILQGETGEDAYLRRLALSQASPPSAPAREERDGSPLAYNPFAPPSSVPPPPTLAPPMGTTLSEEKVRSSQQVAAAIAAKLRALAPPAGSDSPELSAASSSQSPVPEAAPKRPDPRGFAERLMAKWGHKEGQGLGADGSGIVHALTVEQVAGGKGKGRGGKAKEQGNKSIGVGSKMGKIVNLNEDAKTREDRERFGEPSRVVVLTNMVGPEDVGDEDLREEIGDECSKNGTVERVIVHLVQPPPEEPEDAVRIFVLFAGPVGAWKTVRELDGRYFGGRSVRARYFPEARFNQFAFDAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKN7</accession>
    <name>A0A401GKN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0411200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613648.1">
        <property type="nucleotide sequence ID" value="XM_027757847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKN7"/>
    <dbReference type="GeneID" id="38779652"/>
    <dbReference type="InParanoid" id="A0A401GKN7"/>
    <dbReference type="OrthoDB" id="2802317at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7870" checksum="CA4E27769CE5A1F6" modified="2019-05-08" version="1">MSLYPPISQASFKAESKCLYDVPFLESNGRNFQMWKYRTTSILWLRGLYSLIDGTEADPGTADTMKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKR3</accession>
    <name>A0A401GKR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0411480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613676.1">
        <property type="nucleotide sequence ID" value="XM_027757875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKR3"/>
    <dbReference type="GeneID" id="38779680"/>
    <dbReference type="InParanoid" id="A0A401GKR3"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE82763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="313" mass="32938" checksum="FE1A765363EE7A15" modified="2019-05-08" version="1">MSSSEPSRRPAAQKRRLEPADDEAGPSKRLRTEATNPAPRTGGPSTSGQTVELETDRLEADSGTLAAARPVQGANGEASRTDAADKGKGKAKDTDTTTRKDTGKGGADPSTHKIRKLVPPRPFPTVPTSVSATGPRSAHTEGKNYICITRHTPLGGYLRRCKDVILKDGYKNLHLSAMGAAIPHLMLLTVSLPSILPFPPDEVHTEILTGTVEVQDELIPEDEDEDISYRTRGKSTVSVVIKIGDGVDEVLKGKNKRKGKGGGYQAADTVGAAGGNPGAGRRGKKNGKAGRQNTVGGSGPAPIVVREDEMETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL07</accession>
    <name>A0A401GL07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0412330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613759.1">
        <property type="nucleotide sequence ID" value="XM_027757958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL07"/>
    <dbReference type="GeneID" id="38779763"/>
    <dbReference type="InParanoid" id="A0A401GL07"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="64" mass="7352" checksum="8808FAEAB07856A8" modified="2019-05-08" version="1">MALLWGEGLLYAKLLKQKGMKTKDDVYPGVPHRFHYGLRQIKIVFLADKDFDNELKWLLSGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL53</accession>
    <name>A0A401GL53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0412610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613787.1">
        <property type="nucleotide sequence ID" value="XM_027757986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL53"/>
    <dbReference type="GeneID" id="38779791"/>
    <dbReference type="InParanoid" id="A0A401GL53"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16295" checksum="9E1B5F55E451E0E5" modified="2019-05-08" version="1">MSTSADNTSNSNAYRIPLLKEDNWLPWKRRIEAILNDKGLQEYVTRKTPKPQPSNDPANRAAREAEISAWGEKDLKAQNVIVLSLGDSQMVHIAGAETARAMWEQLRTVKEQRGQHGILALCRHFYRMQAKEEDNISSHITQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLM0</accession>
    <name>A0A401GLM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0501370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614004.1">
        <property type="nucleotide sequence ID" value="XM_027758203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLM0"/>
    <dbReference type="STRING" id="139825.A0A401GLM0"/>
    <dbReference type="GeneID" id="38780008"/>
    <dbReference type="InParanoid" id="A0A401GLM0"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="95"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="461" mass="51177" checksum="8BC174D728A3ADA3" modified="2019-05-08" version="1">MATLEYVEIPSYATRLHSNVPNHDIRPATKIVTSLPHPERATVSLSSPPTSQPGSPSVFNMPQMLLSSALQLPANVPATPRNTGNASRLITTRDPLSIPITTVNFKRFVAKAGPVFWLQDRFEEILMWKKGWKYTLVWMAAYAFLCCFPRMILLLPHVALLSVLLATHPSLRNPSTCDDLDDDVANGIASSMPPQSGEGSVAWLANMQAIQNFMGAYSDVYDFLLPAVPHLTHGTPYTPILLSLTVISILLVLPLVAFLPLRPTCLTLGIAPFLVTHPLTRTLLPGFRGALVRLDARAVRAADDDRLQDRHWRAEMREVELWENERWRPASSSSTGAGAAEDGGAGANAGWGKANLRPAERRAWTRGRDGWSGVADDGSGDVSSNLTFSLSDGWFFVETEDWRPDVEGSWIETGSDGNGWVYTNDSWQDPHPTPVEEWRAQRLTRRRRWTRRIYYDPASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMD1</accession>
    <name>A0A401GMD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein arginine N-methyltransferase SFM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0504490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614314.1">
        <property type="nucleotide sequence ID" value="XM_027758513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMD1"/>
    <dbReference type="GeneID" id="38780318"/>
    <dbReference type="InParanoid" id="A0A401GMD1"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="244" mass="27372" checksum="D842485798AAFD27" modified="2019-05-08" version="1">MYSRDDIHCEYPSYLTSTVVQWVSPMSLDTAEHMEEDEDTSKSIPKWVELEYMHMRSLAGPGAHVHFTHLSQSSCPSLSSLFDRGTPTESSESAQASSHQVSVMELMKANDIPLIKVCLLDPKAEKELSPEDGDGRFSWFLFGGILGDDPPRDRTSELRALGFPTRHLGPVQMTTDTALGVTKIVVQDKVSLSKIPFIDYPNIVFNAKESVEMPFRYIANGNEPILPAGMREHLYDDLNQSFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNB3</accession>
    <name>A0A401GNB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0507870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614644.1">
        <property type="nucleotide sequence ID" value="XM_027758843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNB3"/>
    <dbReference type="STRING" id="139825.A0A401GNB3"/>
    <dbReference type="GeneID" id="38780648"/>
    <dbReference type="InParanoid" id="A0A401GNB3"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="12">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE83731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="201" mass="22283" checksum="3D8889C6F137E626" modified="2019-05-08" version="1">MRWPLHDQLAIAHALFACIAVLFTMPIALLAARYLRHGPRWFRIHVIFNGITTFLVILVFGLGMGAVSTQNLGTQFNGPYSDLHHKLGLTIFILVLAQTILGIFSHYYPGGHISRRVHVAFGTIVAAGMIWETWEGLHNEWAEMSVSMTVTPQGVQIVFWAVFMVLAIAYGAAVGQVALRKVAVQTYEDVKSDEKLPISVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNX8</accession>
    <name>A0A401GNX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0509860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614840.1">
        <property type="nucleotide sequence ID" value="XM_027759039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNX8"/>
    <dbReference type="FunCoup" id="A0A401GNX8">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GNX8"/>
    <dbReference type="GeneID" id="38780844"/>
    <dbReference type="InParanoid" id="A0A401GNX8"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="167"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE83927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="334" mass="37736" checksum="A319AB4A8332EB01" modified="2019-05-08" version="1">MPIVFQTPISIDTAHAFAAFFTFSYVGSLYVSKNARLSFKKKTVPKLKDGEQRAKERDERWRDDPEVIRARLVAVGTSTVLSCGAVFLLIWENVGSGPGTFRIALESTLARLGLFLDFSHRSPYAIVLPCLTAPALFLGPLFAEYLASALPFQRRWSIRFSVLPIFATWQGWRNYIVGPITEEVVFRACTLAVYHLAGVSRNKMVFLSPLTFGAAHLHHAWDTFNRYGRTGAAARRALVSSVFQLAYTCMFGFHCAFLFLRTGSLIPPIVSHIFCNIMGIPQYGLHITHFPRRRTAIKFAYILGIAGYVYAMCNWTLADDSLYWPPLPRLFPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPA2</accession>
    <name>A0A401GPA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase gedA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0600230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614959.1">
        <property type="nucleotide sequence ID" value="XM_027759158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPA2"/>
    <dbReference type="GeneID" id="38780963"/>
    <dbReference type="InParanoid" id="A0A401GPA2"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="74"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="257"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE84046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="448" mass="49303" checksum="9775021FB19EAC50" modified="2019-05-08" version="1">MSTTSARAEKLLAVVDLVVNAAQVVIQEWTKEDATGAQKALSASVDLFKAQRTILAACGSFTEILQVPQRRILEVANQYFEARALHIVVEHRVAHHLAEVDEAVGMPISELSKATGLHPRKLSRIMRTLCSMHIFAEVQDGYFANNTVSATLATNEALEARILLGAWVYYPASAKLLEIVGDPVKGWSNSATDCAFQEGHGTKLSLFDWLEEGIIQPDGSVKPRPALERFTVAMVNSSGVLGTPPSYYFPWESLGSATMVDIGGGVGGMSFDLCNQFPLLNFVVQDRPAVIEKAEPVWQRERPEALKAGRVQFMPHDFFTENPVKGADVYLLRHILHDWEDDRCVDILSALRPALSPHSRVLVVDMVMNTTLGCPEIPSAPFPLLANYGTSIRFAHESDLKMMSMVNGAERVPADFRSIAQRAGLEFTRILECPGDCVIEMRLPSVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPG5</accession>
    <name>A0A401GPG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0601090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615044.1">
        <property type="nucleotide sequence ID" value="XM_027759243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPG5"/>
    <dbReference type="STRING" id="139825.A0A401GPG5"/>
    <dbReference type="GeneID" id="38781048"/>
    <dbReference type="InParanoid" id="A0A401GPG5"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE84131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="880" mass="95778" checksum="C2FF3D2CE2537602" modified="2019-05-08" version="1">MSTPAKAEDTQEKPGAPAASTPTPTSSASVLKERRFKLSRACDRCRRRRIKCDEGHPCQSCLTSNSACTFEEPGKRTHPHKSKRAATLEDRMHQLETLIQAIPPAVFAAGGASTIPQSPVDATTNPHASFASSTHTFPTAVPPPSLNAYPLMNPSTFFTPVKSVSRHASPSAGFPPPSSGVGAADHLAEETAKMSLSSSYLYFDDEGHTRWQGETSGLPLLDLLVERHTQVTKPDPDHGPAQSWASQNGHAMNDWFPDRTPKKTDTNPEVIWRLITSFIVPELMDSLVQCFLSTSYYLMPFLHLPTFLADYGNPRKWGEPGFAAFIVAVCCLSSRHIDDPRVRADPNDGISAGTQWFDLFGRLRTLPSADRPTLYTVQSVLIAGVYAVGLGQLSKAFALLAEAVTLSIDAGLHRSVDDYDVFDPIEDEVRKRTFWCVYLWDKQACAHFGRQPILRLRDCDVSEPAVVDDEYITRDTLGVQPPEIPSRIGAFVCCVRLFVILEGIVDVPPPRHFGDGPSFLSRATAVLSGYKCTKDLREEEALLDEICRSIPPHWAHTVETMTSEDVLRVTQSQRLHCVEQYVRMLIHRHRFSDLVVERTQSPFNEQTEAECEAMRAAHAAALQIISSHLHTATKGLMTYYGVHVIHQLTAAGRTLVAVLLSCHTEAMQPLIAPGLDALRSCVGLLRRFSGRYVCGQRSGDLMEEFCRLTQIPLDSARPQDTPISSNNRPPWLRPVRKKTPSMARSPGSNGDSPSHHGSPEAFSPSDAFLDLGGGTSPRPPSAPFPSANPSSQGVAHAFSQTYGLGNPVAASASQFMDTDMLVGEAGLSMSPAEILALFNDGSVDMTSLLMQPGSSGQAAANGFYIPSSASGSGPVNMVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPH4</accession>
    <name>A0A401GPH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication factor Dna2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0600960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615031.1">
        <property type="nucleotide sequence ID" value="XM_027759230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPH4"/>
    <dbReference type="STRING" id="139825.A0A401GPH4"/>
    <dbReference type="GeneID" id="38781035"/>
    <dbReference type="InParanoid" id="A0A401GPH4"/>
    <dbReference type="OrthoDB" id="3265726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="11">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE84118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="282" mass="32122" checksum="FC66BE84EDEFCF79" modified="2019-05-08" version="1">MEVPTDCRHQEWRCFILRDDWADADDHVGDIVNVIDTFEPTPSSSSSGPMLSIAVSAKCGRKVLMSKLTWRSLDVTHVLMWGNMLHEVMQMYPAEGRWYERWVDAQITDVVGRGLSELIRINMSIDQAKVGMKAWAKELKVFAEKYISQEPKVDAVPLLHDVEEDIWSPRCSLRGKVHASVPAVIFEIDGESSPFMRAAPMHTTQNWTMPLEIKTGRAVAGMEHCMQTMLYTLLMAERYRTEVPSGLLYYTQSEEVVHVPATRNEVRALLVAQNDMAGYMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPX2</accession>
    <name>A0A401GPX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0602440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615179.1">
        <property type="nucleotide sequence ID" value="XM_027759378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPX2"/>
    <dbReference type="STRING" id="139825.A0A401GPX2"/>
    <dbReference type="GeneID" id="38781183"/>
    <dbReference type="InParanoid" id="A0A401GPX2"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE84266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="514" mass="57099" checksum="56DE999429F012F2" modified="2019-05-08" version="1">MDSSFMHAVDPFAAKRGGVFWQFLNALSATAIVRCWPLLVFFTGWATAISCISHFVHNVGIQSTLLTVIGTVLGFVVSYRTTSSFERYNEGRKLWSQIVLASRTFARTTWFHVPEMMPTGADDKSTVEQRKQRVLIEKKTAINLVEAFAVAVKHYLRGEEGLYYVDLYHLVKFLPSYALPAGLPSAVDISETSGSPIPSDSENGRLSDVTSLRSPEAPTSGNPVSSAVARGAHLPLPVTAKSSNRTAFLDIRVNSATKSLSDKEKNLGVVTSATEDGFLLPARNPPRFHLFDVFPFSLFVGRLTEAGKDVKGKRAARLRAKMQRETKTHNLPLEISLYLSSYVAALQTRKAIDAPTSTNLLNALGQLVDALTGLERILTTPIPFSYRVHLWTVTTLYCFFLPFQIWDPLGWLTIPATCLLSFIFFGFLFAGEEIENPFGYDKNDLNMDHFTHNIIRNELRALTALPVPDPSVWAFSPLNDTVLADPMVQGIERVSPDEWMQRGYSHMQAALCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ41</accession>
    <name>A0A401GQ41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0603330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615268.1">
        <property type="nucleotide sequence ID" value="XM_027759467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ41"/>
    <dbReference type="STRING" id="139825.A0A401GQ41"/>
    <dbReference type="GeneID" id="38781272"/>
    <dbReference type="InParanoid" id="A0A401GQ41"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE84355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33131" checksum="D72140F1745A0972" modified="2019-05-08" version="1">MFQITREAQVPRELVPALDSSLLVLSETQLTFLHALVSPDDQELRRKILAVQKGAYERYPYPCIRSFHHVSLMASANPVYSAVLNAGRSGNTIFLDIGCCMGTDVRKLAFDGYPAPQILGCDLRQEYIDDGYKLYQDAATCPIHFFTSDIFSVPVSFDARTPGSADISTVTELVQLQGTVMHIYTGALFHLFDETTQYAIALRVAALLKHEPGAIVFGRHSGLEHEGMIDDHLGRTRYGHSTTSWPLLWKKVFAEAEGAEFAETRVVTEVKREEHPYSLSRQRGQHMLIWSVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQI0</accession>
    <name>A0A401GQI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0604340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615368.1">
        <property type="nucleotide sequence ID" value="XM_027759567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQI0"/>
    <dbReference type="STRING" id="139825.A0A401GQI0"/>
    <dbReference type="GeneID" id="38781372"/>
    <dbReference type="InParanoid" id="A0A401GQI0"/>
    <dbReference type="OrthoDB" id="3239894at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="198" mass="22106" checksum="77018A83D10462A8" modified="2019-05-08" version="1">MLRAFKRDAQIHSMVHYVSQSKGTSDGDISAHIAQHLLHENREARGTVESIAQELAYVADDVLSLLPISLDPPSNQGVKLSDCTRASLYKLYNHDHKQVYYPTEANVPRSAHFLQQYGQVHDYALVDGRRIMPVTHSSKLSAASAIVKVDLNGNILAGEVMSVFEHFQGGVTGDMVFAEMQWMKQLDRVPISDDIWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRR6</accession>
    <name>A0A401GRR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">SCP_0700980</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615830.1">
        <property type="nucleotide sequence ID" value="XM_027760029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRR6"/>
    <dbReference type="STRING" id="139825.A0A401GRR6"/>
    <dbReference type="GeneID" id="38781834"/>
    <dbReference type="InParanoid" id="A0A401GRR6"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018984170" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="22"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="233"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="602"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="GBE84917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="643" mass="70159" checksum="FF4E6568976D2DB1" modified="2019-05-08" version="1">MLVTPRLLAQASCLFAVGTSALAPRVVHESRRYLPSGWTPVRRAEPSIVLPLRIGLVQQNLADIETYLLDVSHPDSPNYGEQWSPAKVASMFRPSSESVDAVHGWLVESGVDAPRVRLSAGSGWIQVNVTIEEAEHLLSTEYYVYEYGSGEGVEHIACEGMYHLPEDVSKHVDFITPTLHFDAKPKRNPELKKRISARQVNANVSIANISSIYPKTTGTAKSVFNNVNYCDEQIIPDCLRALYNFIYEPTVADNNSIGIVEYTPNVYVPSDLDEFFDEFSVSQVGERPILYSIDGGYLQTVYTGFYFNGESNLDLQYAMGLLGPEQSVNLYQTGDMVEGASFNNFLDALDGSYCTFEGGGNLDYDAEYPDPYGGYQGPEACGTIPKSYVITTSYGYSEAQLTPAYVERQCAEYAKLGLMGITVLYSSGDDGVGNAGLCLTDDGELSYNPYATRFNPSFPGGCPYITSVGATQIVPGNTVYQPEEACETVIYSGGGFSNVFPLPKYQEKAVKNYLNKYPPGYPADTYNCTSRAFPDLSANGANYLVVVQGEYYMVYGTSASSPVTAAILTAINDARFAVGKKSIGFINPAIYTEPFMQAFNDIVAGSNPGCGTEGFYAQPGWDPVTGVGTPNFVKLLELWLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GRZ3</accession>
    <name>A0A401GRZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Origin recognition complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0701570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE84973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615886.1">
        <property type="nucleotide sequence ID" value="XM_027760085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GRZ3"/>
    <dbReference type="STRING" id="139825.A0A401GRZ3"/>
    <dbReference type="GeneID" id="38781890"/>
    <dbReference type="InParanoid" id="A0A401GRZ3"/>
    <dbReference type="OrthoDB" id="3358956at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49477" checksum="5DB45868E9A3ADD1" modified="2019-05-08" version="1">MSRTQIATLEKLCGRQETFTKSEALFHSAVAKTGPGSGYSLGDASVGLPAICAYIASLELGNGDVSEKVAQTASCVTVKQFKTAVQTVRAALAAAAAPSQELETALSYDSLMRKYHVGRKRFVHDCLCDVEKALVASRELPPDLHPPCDAVTVAVFYWTCAVVLKMKRKNIQPEVVLRERGLVRDDYDEIIDILQTSCQDVALKVDAKVAELRKEVPTPTAGPSASTSSATATPNVSPTKSPTKSALKTRPLDASPTKTPTHKRKVAFHDLATDEDQSVLETPTKKRRTSPAKPVLPQLSVLPVPVSTRPSRSPTKRGPFPDSATSSSRAMLNPLQTSEEDLDRSQQPAFPLVASADFSGQGPSTPRRRAPQTPTSARRASSNGLETPTSVSRMGRQAPRLEILDEPPRPRFRPVYLDHRQWVSRDPRIEREWRLVEEFRRSLVVSNRAEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS44</accession>
    <name>A0A401GS44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0702090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615936.1">
        <property type="nucleotide sequence ID" value="XM_027760135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS44"/>
    <dbReference type="FunCoup" id="A0A401GS44">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GS44"/>
    <dbReference type="GeneID" id="38781940"/>
    <dbReference type="InParanoid" id="A0A401GS44"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="216" mass="24477" checksum="C72332746CFAFDB9" modified="2019-05-08" version="1">MPVGIEAWVTQIPPVTRTWLILAVLTSLAVQCQLVTPLQLYFSFKAVFTNAQPWRVLTTFFYFGTISLDFVFHMFFFMRYSRMLEESSFANRKADYFWLLFLSSIMLLALSPLVNLPFLSSPLAFVPIYMWSRRHPSTPISLFGLVTITAPYLPLALVGIAWALNGTWRAAAGDLLGCAVGHISWFVRDVWTREMVGGHTILSEAPDALKRLFGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSC2</accession>
    <name>A0A401GSC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0606130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615547.1">
        <property type="nucleotide sequence ID" value="XM_027759746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSC2"/>
    <dbReference type="GeneID" id="38781551"/>
    <dbReference type="InParanoid" id="A0A401GSC2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7380" checksum="F1CA15C4AB5E837F" modified="2019-05-08" version="1">MPSLAAFPPSPSITVLGGFTDPHFTTVALPIVVFKMCTTTTQVRAVWDSKLLSSFVVHLSSHTRTYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSJ1</accession>
    <name>A0A401GSJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0703710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616098.1">
        <property type="nucleotide sequence ID" value="XM_027760297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSJ1"/>
    <dbReference type="STRING" id="139825.A0A401GSJ1"/>
    <dbReference type="GeneID" id="38782102"/>
    <dbReference type="InParanoid" id="A0A401GSJ1"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="407" mass="44463" checksum="9733EE8B26CB5836" modified="2019-05-08" version="1">MQGSQLKKRYSAEQKKQLLANLDLEVDHKTRQLEEWLADALENFLRHQEGLISRTPRLVRDITMLEFAKYKGNVQECVKGLKREILGAEDTAIDRSTRKRKWVASQDSTERVDVKVGHDPAGVGESSRGVKSARTMPTTPQKMAGPSNGVGTAQRARFPLNKTPGTIRTIKRIPSGMNTPTRKAVTAASSKPPFFARPASPTKLPSPSKRPIRPPSSSSFNPILPAHAMQPRWPKYNESMLSVNGSPLANPYQLGLNGWLRTVSESEGTERADSDAESERGGKKLVRKASSIIVRSSGESGGHSRTNSQTSVVAPPHGTHSRANSQTNAGGFVPNRSNNVADPAPHLSLTALVSVPTKDGHILEFDPLQTSPEELDTLEGISDSAKKQAKLDIVRLVQTTVERWKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GSK4</accession>
    <name>A0A401GSK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0703360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616063.1">
        <property type="nucleotide sequence ID" value="XM_027760262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GSK4"/>
    <dbReference type="STRING" id="139825.A0A401GSK4"/>
    <dbReference type="GeneID" id="38782067"/>
    <dbReference type="InParanoid" id="A0A401GSK4"/>
    <dbReference type="OrthoDB" id="5582002at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="390" mass="42537" checksum="55CF270FCD9534C8" modified="2019-05-08" version="1">MSGMDYDRRSQVSSFYGGRKSSDALNADFSPSAPQYGQPQHTRLDSASSFYNADPNPRTSVDVHGGKRGAGYNRMSFIHTGREEPVKGGADEESMLSKDDGWDIYADFNNAGPRYSSAFVSNDSGYRQVPSPSPLKLEENLNSGAPVELVTVPALGPEWKAEELRGMTKAARREEARESFAQKWTAWNRGERGCCGRYGTRRFTVYFVFGLCIVVGIILAFTIPRVPSFAFSNTTPLGNATAPFNETIPTEFSRSPANFSFPAVANIQVNTQGNFIPLHISSMNALVYDLTTGRQVATGHTGSLTLPAKAYPYIQVPLNFSYIASNDSDQTWANWYNACKNPAAITEGSRPPVQFNFFLDMSIIGLVGKKSTSAAVTEASCPITLSLNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTC6</accession>
    <name>A0A401GTC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0706620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616388.1">
        <property type="nucleotide sequence ID" value="XM_027760587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTC6"/>
    <dbReference type="GeneID" id="38782392"/>
    <dbReference type="InParanoid" id="A0A401GTC6"/>
    <dbReference type="OrthoDB" id="2844016at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="131" mass="14668" checksum="6CCA451414FBFA38" modified="2019-05-08" version="1">MLSAFYSCHYTDIPLLSLIDDSLIPSNQSEPQVYSNNLAVSANSQPTLCFFTEESELPAPIQNYCIVDTFDSAFPILAVNGVAHKFSLCESDTQYYTGFPNDVIFEAMEDSGNIYNYTTCYPVRLQVVYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTM5</accession>
    <name>A0A401GTM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0800980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616494.1">
        <property type="nucleotide sequence ID" value="XM_027760693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTM5"/>
    <dbReference type="STRING" id="139825.A0A401GTM5"/>
    <dbReference type="GeneID" id="38782498"/>
    <dbReference type="InParanoid" id="A0A401GTM5"/>
    <dbReference type="OrthoDB" id="8054889at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="259"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="621" mass="70681" checksum="4B5C710EE5478BE0" modified="2019-05-08" version="1">MPWLKRLNPMINWETGDFWFGKDAKWPPKPTIEDAPDEEGSIFKEDGLPELITTETSPTSFGHSKSIREIMADNTERGELPAVRNDTEPDDPLSEPPMDQLDDDDLVISYIAGEPVIGIFEPIRKESPLTNEETETAVFTIRRGPAIGRMTHSTRSPLFCNAQNTVFYKPSGKSQELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLSLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDRALRPCQNYRYLNEGTVKNAYPLPLISDLMDQFKGASIFTKMDLRSGYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHIRTRRVLQRLKDNDLFLKLEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRFFLGFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTTECQTAFDTLKQRFSTAPVLLLPDKAKPFIVEFDASKSATGAVLRQADINGDLHPCAYISQTLNPAERNYEIYDANSSESFEPSLNGAIILKALPIPSKFAVITRTSRTSVQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU05</accession>
    <name>A0A401GU05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0801830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616576.1">
        <property type="nucleotide sequence ID" value="XM_027760775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU05"/>
    <dbReference type="STRING" id="139825.A0A401GU05"/>
    <dbReference type="GeneID" id="38782580"/>
    <dbReference type="InParanoid" id="A0A401GU05"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="666" mass="72850" checksum="430F8356395EF32D" modified="2019-05-08" version="1">MNRIASPPPSGYISGIVLHVDAYGEQLPEALTYYKAHTQYIAIGRRPTQQKGASGDDNRALFRCAVVSRKHAKITFTEFGNAYIIDLHSHHGTHILRPGDTVSRMIEPESPTVLADGDMLTFGKSVGKDNSLVRPVTVRVKLIFGSQPVLAPLDFEATPQPMERVSSRFSSRRYGIPLSTDVSSSSDGESDIEEVTEVVSPPSSLLPVQAPCTSGYCSSLATGRLALLRRLLPPIHSSLNSRDSPRSVSPDVDHLSFFEEEMTDVAVRNCVREALEISEQAADIPPPPFIRDLLLAEPNVVGAYPDSPIRPVSPTSDVHPSVEEPLEMAVDCHNYPISERDDYMDRVLAEGCDLDFEPSVSDCRTSVQNEHSPFISNAGNGADDITERIAGEESLPLPSVEVGFGQGVAEHDEGVHSYPTPSPEQGHCCVPSCRGNTVDSPADGADASVAIASLERQINNACDDITLLRMTRRENEDLFQEHVRQTKARLDDLRDHMDIHIMSNVHVNTSNLTNMQSRLDGLQEKMEHMESRLASKDQCTVEPEVEIDGHKALLEEVRALREETAQQIAIEFEAIKAARLDAEAAVTKAVADAQLQMAASRMKRKFSDLEDTQDSHSVQDNGSPSERPVIQLSKRRKTMKVVSRIAQTATVATVGAIAAWAALAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU55</accession>
    <name>A0A401GU55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic expression up-regulated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0802700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616661.1">
        <property type="nucleotide sequence ID" value="XM_027760860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU55"/>
    <dbReference type="STRING" id="139825.A0A401GU55"/>
    <dbReference type="GeneID" id="38782665"/>
    <dbReference type="InParanoid" id="A0A401GU55"/>
    <dbReference type="OrthoDB" id="5595379at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF3">
        <property type="entry name" value="TRANSCRIPTION REGULATOR RUA1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="2">
        <location>
            <begin position="334"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="519" mass="56793" checksum="1EA2D76F31820CB9" modified="2019-05-08" version="1">MKSVEQQHLGYSVYPESAIRDTADAADDVLPVATHDDSPFFVANILNDLRSTPSFGQYPQTFSPFSPGTPFRTLFASSPSGFWRPADSSVSPVYHTSPPSYPHAARPHGHHKSSLLSLARYASAVLQNGPLDPLSPLSSISSLPSSPSTDGSPLPRIAHGSASSPQQKPQTTEPAWCYSRATRDRALPSSRTKVPPARASRYCTRSQSARLVASTCARAASRSRRTPDYDDIACDGEDNVPATRLRKRRAEPTADSTLKRPRLTSNNEDALHSEPEVPAVVSTSPNRTFPQHIPVNGDFPLFYRRFPASSYALTGSDTSSHGPSDAVFNLPTDPLSLYHPRFVKGKGRTKIGLCPCCYEDPVRGGEGKKVWLSLKFSAFNYHMQFGHGISAATGLPFSPPIEFRCIPRTEVGKHEKVQMTQGLCHYCKEWVPIEGIKDVPVKVKEIFWWKHAASCHQGSSIIGERDFYIEDDVYRSRLAECNASEDVESPEDANAVHGDDADTVHGVDDAGSDSAAQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU57</accession>
    <name>A0A401GU57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616678.1">
        <property type="nucleotide sequence ID" value="XM_027760877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU57"/>
    <dbReference type="GeneID" id="38782682"/>
    <dbReference type="InParanoid" id="A0A401GU57"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="59" mass="6649" checksum="C012EBED45BA44D6" modified="2019-05-08" version="1">MSQYSHLSTPDPEFRAPIPHPPNFSFTGDVKALRERQRQFQAQNRESLAARLPAGKLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU73</accession>
    <name>A0A401GU73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616681.1">
        <property type="nucleotide sequence ID" value="XM_027760880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU73"/>
    <dbReference type="STRING" id="139825.A0A401GU73"/>
    <dbReference type="GeneID" id="38782685"/>
    <dbReference type="InParanoid" id="A0A401GU73"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14572" checksum="5BFBD43A35D10CA4" modified="2019-05-08" version="1">MQVPPPLNPEAPEGEKYRAELLSLEQNKDAPTLTRIVGIPKDDRIFSLLLQPSHAGIPPLYLQVNDPDPLRDEGLLYAKLVEEAGVKTKVDIYPGVPHGFQYIAPQITAAVKSSKDFGEGIKWLLSLRSGASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUP5</accession>
    <name>A0A401GUP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0804790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616868.1">
        <property type="nucleotide sequence ID" value="XM_027761067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUP5"/>
    <dbReference type="GeneID" id="38782872"/>
    <dbReference type="InParanoid" id="A0A401GUP5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="84" mass="9462" checksum="406409E2F8D4FAE2" modified="2019-05-08" version="1">MGVGLPGLDISRWLLVVSGRATARYSRRIHVYMVWSDAIRLLRTAYRRKHLVTVGCMGIVLDRSMILIAPSFVYAALLRTQAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUQ9</accession>
    <name>A0A401GUQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0804820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616871.1">
        <property type="nucleotide sequence ID" value="XM_027761070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUQ9"/>
    <dbReference type="GeneID" id="38782875"/>
    <dbReference type="InParanoid" id="A0A401GUQ9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14950" checksum="E014B6E09B4D39F1" modified="2019-05-08" version="1">MQPPYLDTVCREILRVQPLLTILDRLRGLATIRTDTRTQRHDDERDTCPQGHQNIVGVAGSNLSKVLWAEDSLEWKPERWLSPLPSAVTEAHIPGVFSNLMTFIGGGRACIDFKFSEMDMGASLSCVGGLMSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVE5</accession>
    <name>A0A401GVE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Retrovirus-related Pol polyprotein from transposon TNT 1-94</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">SCP_0900490</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617085.1">
        <property type="nucleotide sequence ID" value="XM_027761284.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38783089"/>
    <dbReference type="InParanoid" id="A0A401GVE5"/>
    <dbReference type="OrthoDB" id="2715572at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0229">DNA integration</keyword>
    <keyword evidence="20" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="19" id="KW-0917">Virion maturation</keyword>
    <keyword evidence="24" id="KW-0862">Zinc</keyword>
    <keyword evidence="24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="26">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="27">
        <location>
            <begin position="574"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="311"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="832"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="869"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="GBE86172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="30">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1478" mass="163984" checksum="810F1AECA43ABC16" modified="2019-05-08" version="1">MSPASESLQSHLNVIPKLAADGSNWITYKERMFTVMGSRGLLRHLQGTARRPPDPPPLPMPSPAQAATTASTTPAATASTAATSRTATTTAPVTTTAPAGQTQPSMTPEEYLKIVEAAEQKLDEYTQKEFAARQQIYGTINDRLLLRVKKLVTVAEVWIAVQNEYESKSEMYSGALRTRLQNTKCEEGADARAHLDTLAKMREELASMGAPISDADFTAHVFASLPESYSALLQALSTAARIAKTTISADDIITSIVEEYDRRKAHLKPESALSAKADTRSRSHSKSRGHSAKSKDAECYNCGRKGHFSRDCWREGGGKEGQGPKDQASKKGGSSSSNSKGRSSANTAVSDDNQTHAFTATFDSAALVHHPATLPDVEIEVYDSGATRHMTPYRDSFVSFEPMPVKPITAADGRNFSAIGRGTVQLQIPNGEQMTTVLLEDVLYAPEIAFALISIARADAAGYSAMFEKGECRIYSRRQSRIIGRVPSLNGLYKVEHSRRAAPVNESASVAVEPEVERALISLSVMDFHRRMGHISPIIAERLVREGRVEGVRLTDKANKEKTCNSCIQAKITRATVPKERESDRTKELDDRVHSDVWGPAQTETLGGKKYFTSFTDDATRWTDLYLLRAKSGTFSAYKSYEAKLKNQDGKTIKALQSDRGGEYLSREFTDHLTTHGTVSRLTVHDTPQHNGLAERINRTLPEHARAMLIAAKLPKNLWGEAMMHATWLKNRTSTRALDGKTPFEVRYGHLPDLGDLHEFGAKVWVRIENAGKLDSKAREGRFVGYSTESKGYRVYWPDKHAVSVERNVRFIDETVIADEAQPEGAIEAVVPSSPSTLHQPQQKPKSHTEPPAPSSVNPPSMPTSDAPVQEHKDENHAPEAPAERSHRPRKASAYVKRLNDGSGVADGRKSRPKYPQGLQPGDLMGAAAVEAEESESEQEGDEPIFAMPAAFAVREGQEPRSLEEAMQSPDWPQWQKAIEKEMRNLRDHHTYDLVEPPENTNVVGSKFVFRIKRNANGKIESYKARLVAQGFSQIPGIDFNDTFAPVAKLASIRIILALAAHHDWDVHQMDVKGAYLNADLEEEIFMKQPPGQAERGKEHWVCVRHAIYGLKQSGRQWFKKMCAALDEMGLSRSLVDHCVFYLDEDDDSVTLIIALSVDDTTIAGTNNAVLWFKTEISKRFEMTDLGEMHWILGIEVRRDRAARTLSLSQRAYIDGLMARFNLEDAKPLSAPLEPGAILSIRQCPSTPREFEDMRNVPYREAIGSLMYAALGTRPDIAFAVTALSQFMQNPGRAHWEAAKRVLRYLKSTREKWLTYGLTRDGVEGFSDADWGSSEHRHSICGYVFLIDGGAVSWSAKKQPVVALSSTEAEYIALTHAAKEAIWVRYLLADILDPDVSKFALRLHTDNRSAIALAKDNAYHARTKHIDIRYHFIREAVDSAAISLLYRRTEDMPADIFTKSLPRVKVEYLTSLMGLHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVG4</accession>
    <name>A0A401GVG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0900840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617118.1">
        <property type="nucleotide sequence ID" value="XM_027761317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVG4"/>
    <dbReference type="STRING" id="139825.A0A401GVG4"/>
    <dbReference type="GeneID" id="38783122"/>
    <dbReference type="InParanoid" id="A0A401GVG4"/>
    <dbReference type="OrthoDB" id="3227959at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="400" mass="44814" checksum="AE9525A76494A26A" modified="2019-05-08" version="1">MSASDYSSSDHEETEQSLVRHSDLWFVDGSIVLRAENTLFRVHMSQLSRRSAFFRDLFSLPQPATRLLPSVADSDALDELDVSSQSTMLEGCPVLHLQDAAEDLSCTLKALYDGPNLGTNDREDFQVVSGILRISTKYIIDSLRAKALEHLSIAWPLTLKGWDAREDLAHAYELEHASHRGHLYPSPIAVINLAREIDAPELLPSAFYDLSRYHFTQIFEPGDDEPLGPASLSLSDMQKLALGKEASQHAVTGLIQSMASGTHRESALPPHLAMVHNRRRSSGQICVSAGACRKDFAELVDLATQHYLFDRERGCSDPLYVAEELGQLKSAEFSECKACAKSLEAWAARERERMWKLIPSWFRLDAYGLGSRTRDVSLEHEPKVEQRRSGQSSLRLIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWK0</accession>
    <name>A0A401GWK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0900210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617057.1">
        <property type="nucleotide sequence ID" value="XM_027761256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWK0"/>
    <dbReference type="FunCoup" id="A0A401GWK0">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWK0"/>
    <dbReference type="GeneID" id="38783061"/>
    <dbReference type="InParanoid" id="A0A401GWK0"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019161392" evidence="6">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="92"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="490" mass="50426" checksum="20377FD0591E7686" modified="2019-05-08" version="1">MYYFLPLSLTALVVSTLAPDVIAAPRPYVPVGQSISLLRRPKPQQDFATRAANLKRRRLALEAKYGVGSYKNKKRGSSGNTLLVNQGADADFYGSIAVGTPPVSFNVILDTGSADLWLAGDTTNGSASNVPSGIPLFDPSASSTFQSLGKAFEIQYQSGTALGVLGQDTVQMAGFQVSAQEFAVVTEVSQGMLNAPVSGLMGLAWQQIASSGATPFWEALQQTSGALSEPLMAFQLTRFDNNTRVVPQSGLEPGGTFTLGGVDSSLYTGDIDYQDIPSGETGYWMQQLTGLTSQGKNVTLPSGSSSFAAIDTGTTLVGGPASVIAAIYAEIPGSAPGTGNLQNFYTYPCSTSVNVTLTFGASAIAWPISPADFAFEQASSGTCVGAFFAVDVQGSSAPAWIVGDTFLKNVYAVFRASPASVGFARLSNTALAMNGVNSATPSATVGSAAATASATAKSTHNGSSSGAESSLRARSAVVVLAGLVVGWVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWW5</accession>
    <name>A0A401GWW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0905530</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617586.1">
        <property type="nucleotide sequence ID" value="XM_027761785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWW5"/>
    <dbReference type="STRING" id="139825.A0A401GWW5"/>
    <dbReference type="GeneID" id="38783590"/>
    <dbReference type="InParanoid" id="A0A401GWW5"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="13">
        <location>
            <begin position="134"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE86673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="570" mass="61712" checksum="848D22F7ABC1855D" modified="2019-05-08" version="1">MARKPTRAALSDRTSRQERRLLSSESRSNSETSRSRGLQGLILGAGITLAVGFYVQKNGLLRLDSNTIDPGVSVKPTKTVKHQTLPQHPNASQYASKEEVQMAISELREALPQDEAVTTDQDTLKLYGHSENSYHPTSPHSVVVHVQSTDEVVKVVNIARKYRVPIVPYSGATSLEGHFSGYPTGDICLDMSAMDKILEIHESDGDLVCQAGARWDDINHILAEKEIPLFFPLDPGPGATIGGMIGTGCSGTNAVRYGTAKSEWFLNITAVLPNGKVIKTRRRARKSSAGFDLTKIFIGAEGTLGIVTEATLRLAPVVPSKVAMAQFPNVENAVSAVQEILNTPHGPHIQCVELLDDNMMAAINSAGLVSKSYPVSDTLFFKLQGDEAAISATARAVQGIVARHSGSRFVFAETDEEGAELWENRKYALTSTLASVEGSRCWTTDVCVPVSRLPELVYETKKDLAQSKLQSTIVGHVGDGNFHALILFKNDDELKVVGDAVHRLIRRAIALDGTCTGEHGVGVGKKEYLIDELGEGTVELMRTIKNAVDPLNILNPNKLYPDLPTNGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWX6</accession>
    <name>A0A401GWX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0905700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617603.1">
        <property type="nucleotide sequence ID" value="XM_027761802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWX6"/>
    <dbReference type="STRING" id="139825.A0A401GWX6"/>
    <dbReference type="GeneID" id="38783607"/>
    <dbReference type="InParanoid" id="A0A401GWX6"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019021821" evidence="5">
        <location>
            <begin position="21"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="302" mass="32033" checksum="90CB31A77C455A22" modified="2019-05-08" version="1">MPLNLKVSAALLAVIYAVHAVPAPGLKARQSITALSTTQIDTYTPYTWYSSTGYCNAASTLAWNCGTNCDANPSFKPVASGGDGDSTQYWFVGYDPALETVIVSHQGTNTSEILPLVTDVDIVFTNLDSTLFPGLSSSIEVHSGFANEQAKTATTVLSAVQKALSTYSATHVTVVGHSLGAAISLLDSVYLPLHISGATFTYVGYGLPRVGNQAFANYVDAQPTSVTHINNEEDPIPICPGMFLDFVHPSGEVHIEDYGEWASCPGQDNPSTQCIVGDVPTIFQGNESNHDGPYNGVEMGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX62</accession>
    <name>A0A401GX62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0906300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617662.1">
        <property type="nucleotide sequence ID" value="XM_027761861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX62"/>
    <dbReference type="STRING" id="139825.A0A401GX62"/>
    <dbReference type="GeneID" id="38783666"/>
    <dbReference type="InParanoid" id="A0A401GX62"/>
    <dbReference type="OrthoDB" id="3246367at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35541" checksum="0BBF4BEB97E44987" modified="2019-05-08" version="1">MVFADPPGSSNYIYAEVPVGMLNDEIVDVAFVNLVDWYHFPGGLLALVRAHRFYDGGVSLGEHWKHKYLVDIDGMGYSGRFLSFMESDSAVMKSTVHREFLSDWIQPWYVLENNSTRCCPKPFPYPMLHYIPVSQSYQEIYNIHAFFSGATPSTLKIATLTASDLLPDQRCTMDGDRRLGRIAGAGKQWKRTIGRRVDMDDCFPLQRLNYLQLTTNIMVPTMIDPAVVYLSEEGYDALDRGQRSTSGSRRQKVTTSRESYGLVGGHLSKFFASHDRQLAIASDWFTPAAQGFWLYGFSTFYNVETGLDIQALGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXQ1</accession>
    <name>A0A401GXQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Probable endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_1002510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617918.1">
        <property type="nucleotide sequence ID" value="XM_027762117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXQ1"/>
    <dbReference type="FunCoup" id="A0A401GXQ1">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXQ1"/>
    <dbReference type="GeneID" id="38783922"/>
    <dbReference type="InParanoid" id="A0A401GXQ1"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="9">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE87005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="222" mass="25491" checksum="73939126D5787C18" modified="2019-05-08" version="1">MLAKKRWIKGYVTSVGDADNFRVYHTPAFGWRWPLKFRRIPTASRELKDRTIHIRLAGVDAPEAGHFGRPAQAYAQESLAWLKNQTEGKMVYCQLLRRDQYGRIVAHPHLKPWLLPAFLSRGKCVPLEMLRAGWVGVYEQAGAEYGHGGKEAYMRIQSEAQAARRGMWKHGTDGETPAEYKRRYSSGDAKDTPTSKETPTTSRTKSSREGWFRLLLKRAWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXT6</accession>
    <name>A0A401GXT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1002830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617949.1">
        <property type="nucleotide sequence ID" value="XM_027762148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXT6"/>
    <dbReference type="STRING" id="139825.A0A401GXT6"/>
    <dbReference type="GeneID" id="38783953"/>
    <dbReference type="InParanoid" id="A0A401GXT6"/>
    <dbReference type="OrthoDB" id="3226845at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="469" mass="50943" checksum="0468AF7239D4E4C0" modified="2019-05-08" version="1">MANKGQTADVAAANFIDSLTPPSSASERPRSSGTSLHDHSSDLALMMQTASLYAGTIPLSGKQPVAPADSVRASVSHLLSRACAVPCKKAAEAFTELVQPLSRFPLCLEMLWPLLNSHAPPAQRILASYILYSLYAPHPFILNPFKGVLFAAFCRERELARQVANAGGISENEQLVWVLWKILKGDGQDIDPFSPSTLARSPLPPQLRATNLYLDEETRPKFDPFGDSASDNTGPTPADVTSSTQAAPDVAVSREREEETKKLSDAMTLLLAARNRVLTISEQRMLIPLIPQLTSPPVITSVDLLSVIMNNPTLAQPLLTALLALPPSSTNGYGPGIYLDVLQHLPPTLPSFDLLGRLLRDPTAVPDVTTGGTTTIADLVRTEVLGWFIHECIVWLDKAEQEEREGAISDDRFAKGVQHLCRFYSSLIKHSIVDTGSDADSAEMAHFALRNSRFEDATALYRVLALGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXU7</accession>
    <name>A0A401GXU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1002670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617934.1">
        <property type="nucleotide sequence ID" value="XM_027762133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXU7"/>
    <dbReference type="GeneID" id="38783938"/>
    <dbReference type="InParanoid" id="A0A401GXU7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="132" mass="14896" checksum="D23E9C89AD2F43B1" modified="2019-05-08" version="1">MPQWYWTAYRSESARRMTRSDSRRSRHRRSDHGGAALRMDCSLFLGVPDGRPKIHTDRLAGYHICPPLRPSRQAAAAAARNLCQVAFEGTLSELPAAESPRPVYVSWVFSSAFSVNPDTATARLRTPRLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYI0</accession>
    <name>A0A401GYI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1002810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617947.1">
        <property type="nucleotide sequence ID" value="XM_027762146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYI0"/>
    <dbReference type="GeneID" id="38783951"/>
    <dbReference type="InParanoid" id="A0A401GYI0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="11057" checksum="C61E8CAB4543539D" modified="2019-05-08" version="1">MYSNSNIGPNTDQYHFLEGNPVETLYILTGVCSWQRGGACFRPRRGQCRGHQGPHRSSSAPRLRTASRKRPVEVSRLFRLLTAVARAETQRSVDKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYZ4</accession>
    <name>A0A401GYZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_1100720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618309.1">
        <property type="nucleotide sequence ID" value="XM_027762508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYZ4"/>
    <dbReference type="FunCoup" id="A0A401GYZ4">
        <property type="interactions" value="471"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYZ4"/>
    <dbReference type="GeneID" id="38784313"/>
    <dbReference type="InParanoid" id="A0A401GYZ4"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="86"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="787"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE87396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1040" mass="116211" checksum="6BFBE109ABFE23B5" modified="2019-05-08" version="1">MKPWLYHAWRVYYSKDIAAHGSPRNILSTRIRRAGHVAAKSGNDKAFSDTLLLPKTSFTLWNDPTQNEALRARTCDELYRWQWEHADGPLFVLHDGPPYANGRLHIGHALNKVVKDIINRYHVSVGDRVHYLPGWDCHGLPIENKVLKKLGKHSRELSSNIIRAEAEAYARQEVQLQTSEFRQFGIMADWSPETTYRTLDPDYEIRQLRIFQKMVEKGLIYRRYRPVYYSPSSLSALAEAELTYNENHVSHTVYVAFELDSESPHMSATLRSLIAGRSSARVLVWTTTPWTLTANMAIAVNPDMMYRAVAPDNCPSSSLTIFAVDRESALLDLPEVVTPSNISVAEVNGSELVGATYRPLFASLQHTDVPSLPIIPSSHVTPDAGTGLVHCAPAHGAEDYSVFQSLGLLSSDAAKIVCHVDGLGRFTPDVAEVVGAQAARALIGKEVLGDGGKAIVSLLQDTKFLYGKQRIRHRYPYDWKTDQPVITIATSQWFANLDKVKDDAITALQDVSFVPAASRHRLESFIRNRSEWCISRQRVWGVPIPALHHLPTERAVLDTASLDHIISILQKKGTGYWWDGPVEEFIPPALREGMDEKQLAEMWRKGTDTLDVWFDSGSSWTMLEGLHAKYGSGEGAKGRTFGADVCVEGSDQHRGWFQSQLLTAIGSAKSEERKGLSPYGTLITHGMVLDEAGKKMSKSLGNIVSPMTVILGGEDKRKEPAYGAEVLRLWSATMDLTKDMSIGPEVLSQCSRALRKIRGTARFILGALEDKYPDYKLDRKDLGLAGRYVMHELLKLDNVAREGYAAYDFPKVVNALSNFVNITLSSQYLDITKDCLYADSKDSVERRVVVGVLHHVLTTMTSIMAPILPFLAEEIHETLGNAKGASVFSRKWTPLNTEWQDDNAEQDMNQLFCVRGGVMAAMEEARQAKLLKSSLEAEVLLLVPDDIPEESTLISLLGREENFLKTLFIVSDAYLATEGSLGTQSPDWLYTRSLPIQRDSDLEIRVLVRPAALSKCPRCWTYTRPKDDLLCKRCSDVLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZD9</accession>
    <name>A0A401GZD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1102120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618448.1">
        <property type="nucleotide sequence ID" value="XM_027762647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZD9"/>
    <dbReference type="STRING" id="139825.A0A401GZD9"/>
    <dbReference type="GeneID" id="38784452"/>
    <dbReference type="InParanoid" id="A0A401GZD9"/>
    <dbReference type="OrthoDB" id="3204900at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="523" mass="54850" checksum="0C54984297EFF3C6" modified="2019-05-08" version="1">MSSRTSRPHSFSGPRPLQLVDSNVPNAPPSLSASSCPSPTFSGLCSAPPTVRAFNKPRRQSSISYYPSDHTPQWDLRSPVASSTLKRSSSLGKKVVSTRRRGDRRSTGSMGSLSPAVELGPLTLTEKHADLLRFIAQKESKCLELRSQLAIHEAELAQLKRKWERIVSKGMDRAYSSPASSASPVSILSAVASPTNGAVLEGIKEGMQEMGRIFAAGLGDFSSAPVLSSVSPAISGRKNKGHTTTQSSSSVSTSGTTSTRFTNASSVRLSLSSASSLAYDEPPSEMDEGDETLRPSESRDCAQETITERSTDLVISPSSTATELQAAKIHRRKSREHPPALSVSSSPVPSPVIPSTPHFATPPRSAGGSSASKRVSTGFPTASPVSSWMGTVGSSVGKKWEELQKGEKFTRSQKRASLLLSDVSSSLFAALAAPSPSSPSPAHSGLTSSVSVSSNPFAATLSPLASSPLGASPLSGPTSSVSLLEDDDEGLALGGVMIPDSRPSTQPGLKAESAQNYDDDWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZI6</accession>
    <name>A0A401GZI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1102730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618509.1">
        <property type="nucleotide sequence ID" value="XM_027762708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZI6"/>
    <dbReference type="GeneID" id="38784513"/>
    <dbReference type="InParanoid" id="A0A401GZI6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE87596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="221" mass="24393" checksum="86DE63F17339F66A" modified="2019-05-08" version="1">MPSPHPRSGMFDGIRTSMCQHNSTAPASAQHQNSSPSISRPTKLMSLRSRGREQFTGDKKQTDVEGGASDKHATSWFPRLWNVMRKNDRAEEQMDETSLPRARLHPQLTVRVDAPSTERLLHCQRSCKLMDIRPPPAGSETLWSALEDSDVRDICLISAALVVVRVGKQIFNQSHIGRIFEAAIDGQSEALRCASTVSLVIGLRLGKDVMQLITLLAGPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZR1</accession>
    <name>A0A401GZR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_1103310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618567.1">
        <property type="nucleotide sequence ID" value="XM_027762766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZR1"/>
    <dbReference type="STRING" id="139825.A0A401GZR1"/>
    <dbReference type="GeneID" id="38784571"/>
    <dbReference type="InParanoid" id="A0A401GZR1"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="8">
        <location>
            <begin position="428"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE87654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="630" mass="68865" checksum="0F34A242CC3FBF0E" modified="2019-05-08" version="1">MLVVSFCSHPSIADQLFSTVETEVYMLSNRAFQQVTPNTTTALEPWQSINSAVLNVIADSAPVSSALPNSLQLTIPAGVSGAVGFANPGYWGINVNSSWVYNASLYYRFPYESSFAGNLTIGLQAYSGEVFASKVIPIDGAQTNWTYVKIFLQPSASARTTNNTFFVTVNTSGNAEETINFAFLSLFPPTYKDRPNGMRIDIAETLAEMGPAFFRFPGGNNLGQTTATRWQWNATVGPLLNRPGRVGDWGYVNTDGLGLLEYLTFFEDVGMEPIMAVWAGYSLGGTSLPENELAPYIQQAKDQINFVIGDPATSALAALRASLGHAEPFYLQYVEVGNEDFFASTTWRDFVGNLSAEFPQLKYIATAYPFNPIISPDPLQYDVHVYQTPSWFAENSFYYDKAIPGQRNGTRYFEGEYAAISLNETNLYGTPDDGRLLYPTVQSSTGEAAFMTGLERNSDIVFAASYAPLLQHVNSSQWVYLISFDAAGVVRSTSYYVQKLFSLNRGDLYLPSSLPTYNGTLFWTVSRSSVTGDVFIKVRQLTSDLLNTTHDALQISNTVATPAEIAFELPFPVIAEWGTLQLLEGAQNASNTPEMPGAVVPVTSYIATGNSFEYTAPGYSVSVLTVGTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0M9</accession>
    <name>A0A401H0M9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1202110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618898.1">
        <property type="nucleotide sequence ID" value="XM_027763097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0M9"/>
    <dbReference type="FunCoup" id="A0A401H0M9">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0M9"/>
    <dbReference type="GeneID" id="38784902"/>
    <dbReference type="InParanoid" id="A0A401H0M9"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000057">
        <property type="entry name" value="RAD2p Single-stranded DNA endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="835"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="532"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1090"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1134"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1199"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE87985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1208" mass="133398" checksum="A1151C8E9D18F853" modified="2019-05-08" version="1">MGVKSLWSLLDPVGRPVLLETMEGKAMAIDSSIWIYQFQATMRDKEGRGLVNAHVLGFLRRICKLLFYGIQPVFVFDGGAPTLKRATIAERKKKKSGAAISHAKLAERLLAAQMRREALCHVQAKSSDGKGKGKAPAGPVTLDENTVYLEDLDENTPRTPPKKVPQDGGQPSPPSSKKKSRWQDHDPYKLPEVNLEDVIAKATRSSVPDPRLATEEELSAFIEEMRPEDFDVTSPAFHELPTEVKYEIVGDLRLKSRQTSYKRLQNMLRNAKTPLDFSKEQIKNLKQRNSLTQQLLVTTDSIGKAHVQIPIRIASERNREYLLVKNEGEGGGWVLGIRDEGTQSKPIEIDQNQEKVEEKEGSDDDENMEEVDISAKNTPYDLDLRELRRGQALTALAKRYTPKKLAPLTTKIKKPKPRSQPLFAPDEDEEPAVQASEDDGELSLAIQQSLVYEEESNLRRALEASRSEMASSYGSNIGASTSSSTSALAGPSTPPHHASTSRIEGRLSMDLESDDDDMYASPTRLETALSIGGAGPLRRPLSHAAQPMANSPSSRRQPTFGVPTLLLPRQSPISVAPHPPPAITVSDSEDDMEEVPVPPPSAPSSVQSVARLSTAIMQLPSPPQRPRSPSPLTAPLESDSDDDMQEVLPSVPAQSRSQQSADTAAEFRPTSTPATPLAAPELDIHSVPPRLSGPSTNRDTGEALGVPQERSHSPSPALQFKINYHSNEDEGASGSENENERWSRSPSPTTGPSQDKTAPAVSTAEGWDPAEEMDPQAEEGEFARFISQVKGRDLDTVRREIDDEISALNQQKKVAMRDSEDITQQMISQIMIMLRLFGIPYITAPMEAEAQCAELLALNLVDGIITDDSDVFLFGGMRVLKNMFNQSKTVECFLLPDLERELGLDRDKLIRLAYLLGSDYTDGLPGVGPVVAMELLKEFPGQDGLHKFKDWWQKIQSGRDKPEDTQSKFRKRFKKRFKELYLPDDWPNAAVRDAYHHPTVDESEEPFKWGLPDLDALRHFFNSELGWSPTKVDDLLLPIIHKMGKRGQSSAMNKQGNLNSFFDVPIGGAHAPRKRQAYGSKRLQDVLTDFRKKRDQAERVPGASADSGEESAEKPAKKRKTNGAKVKGKERTARGKTARGGKARKSRKRKQSTAASEEDQNDQDAVVPAQTNSPPPLSVNLRPRPKPKPAYKEGITEPASDDGDIDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0R9</accession>
    <name>A0A401H0R9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-dependent metalloprotease WSS1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1202190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618906.1">
        <property type="nucleotide sequence ID" value="XM_027763105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0R9"/>
    <dbReference type="FunCoup" id="A0A401H0R9">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0R9"/>
    <dbReference type="GeneID" id="38784910"/>
    <dbReference type="InParanoid" id="A0A401H0R9"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="8"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="458"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="495" mass="53637" checksum="5EACF5FC1A9293CA" modified="2019-05-08" version="1">MVHVRLNERETNPNPHVNFISALPMPESAHQEDARQLLRALAAQLRPVMKGHGFVVNSLEEYEHNIVFAGRNWNNGEVVELVLRGASGAFLPVSWLMSTLCHELAHIQHMNHGSAFQALWTKLRNEVRALQSKGYYGDGYWSSGTRLADSSRVGGQSLDASDMPEYMCGGAQKRTRPTSLRRRRGAGAKTGAQTAKKRKAGTRVTARDAFKGSGRALNEDVEDEKGKKAGAGFRKKAGSKRARQERALAAERRLQALQNQASSSSQPPSQNDSDADSDGELDDVEINETDQDRRRAMGEMEQGELEGLRLTQTDFSADFVFPQLTMGGTDESDGFSCDVQSLPRSGTAATTSATKATTSKSASPKGKNKARATSPSQRELEDWLLPESQPADTARSKKKQKVSYGAMVQDEVVFRKKEVIGLAPAPPRRLGGGASSVQPGTRASALGERGPDGRAVRREGETEWSCQVCTLSNAPGHLACSACATPRGESTWGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0X8</accession>
    <name>A0A401H0X8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618994.1">
        <property type="nucleotide sequence ID" value="XM_027763193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0X8"/>
    <dbReference type="GeneID" id="38784998"/>
    <dbReference type="InParanoid" id="A0A401H0X8"/>
    <dbReference type="OrthoDB" id="2758168at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="163" mass="18789" checksum="3B01685AD75454FB" modified="2019-05-08" version="1">MRALLLRDGLVTPDLVDRCIRLYAKDRLLQRSQILHSLDDTIWVDLGRQAPTYHLLLGQDELYRFELARVFYDSRSGKVTAPYTGSAFCRFERTDDKPPRLSLRILKILEPVKCVDPSYDGWVSMPREGELHVRDHQVWTVDLAAKSAPLAAVRRALQVEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1H0</accession>
    <name>A0A401H1H0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1300730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619171.1">
        <property type="nucleotide sequence ID" value="XM_027763370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1H0"/>
    <dbReference type="FunCoup" id="A0A401H1H0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H1H0"/>
    <dbReference type="GeneID" id="38785175"/>
    <dbReference type="InParanoid" id="A0A401H1H0"/>
    <dbReference type="OrthoDB" id="74807at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="174" mass="19349" checksum="A9D3DB498229A29D" modified="2019-05-08" version="1">MAPRRQPTRQTQAASSSAQLDPELVAKRTKRHLDELERSNYTEPSDALFHGLGEDEDGGAGGRSAKGRARRTVSDKRQWDGKKKPKKSSMNVRTAVLYKKNLAVLLDESGIANYPPGVPTYLTAVAPPPLQPPQLFCSVCGFWGKYKCKKCAMPYCDLNCQGIHDETRCERRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H204</accession>
    <name>A0A401H204_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1302380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619336.1">
        <property type="nucleotide sequence ID" value="XM_027763535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H204"/>
    <dbReference type="FunCoup" id="A0A401H204">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="GeneID" id="38785340"/>
    <dbReference type="InParanoid" id="A0A401H204"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="642"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="680" mass="73562" checksum="86DC39EA4C6FAA22" modified="2019-05-08" version="1">MADPDDSFQAADAIGTSTISVFSPSLSRVRSHTPQVHHSSLRPEMSALTPTERDPLLHGARKVKKPFYRARPLWLVPFAISASVIRGMTLGPRIEVFTQLSCNAVYGHDVYDHTTTNLSLVSAYHTPLHIDPVGPHLSRLDFGFSRFRKRSLATFQDTAGTGDEDDNDEPDPRQVPSKRCLQDATVQAGAARLQVIMTTTMGVLSALTTGWWGHFGELHGRTRVLAAATLGLFLTDLTFILVSTPHSIFAAHGHKLLVISPAIEGMLGGWQTLQAAINAYVSDCTSDGSRAQIFSRFTGVSFLGLSIGPTIGAFLITHPIFKSVPPPSSSAHAGTATVTSVFYVATMCSFANLLLALFVFPEAPKKRAKIGQELRTVPDEDAPKRQGHLAGFLAPFALLAPQTVQRPNGTTAKDYRLTLIALTLLVYALSTGIFQIKYLYAEHIYGWGAEQLSYYISAMGLARTLYLLAVMPLIVLTFKPKREPVSHPTHAAVIPSKKAPPTAAQVAREMKFDFVLLRLSLVVDLLSHTLVTLSPESTSAAMFTAYTSLSSFGAGVDPAMQSLALCIMQANGEDNRGKLFGAFAMLRTVGQMIIGPILFGLIYSATVAQFPKAIFIAAGAFAFAALVLICLVRPDAGLRAKVPSRRRDDSEIERGRSRVSKDISHSSMNPTRADSASGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H211</accession>
    <name>A0A401H211_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1302930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619390.1">
        <property type="nucleotide sequence ID" value="XM_027763589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H211"/>
    <dbReference type="GeneID" id="38785394"/>
    <dbReference type="InParanoid" id="A0A401H211"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="179" mass="20489" checksum="408100B23FDB00FF" modified="2019-05-08" version="1">MVLIRKMKRTLGFMMWKADWWEHHAGDMPSRYDIQRGRRAYALRQAAIRCRLAHKSVQCWHAFFLKVSIEHSWILKYLPLNSPGTIARGLDQEDSSPTNAAHLHVTPNTSFAIEISVLAIVPGTQEEMGRDHEHLMDDDHDIIMDDADTQSDSSESDFADDDAQELAGQEEEFDSFDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2M4</accession>
    <name>A0A401H2M4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1400630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619571.1">
        <property type="nucleotide sequence ID" value="XM_027763770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2M4"/>
    <dbReference type="GeneID" id="38785575"/>
    <dbReference type="InParanoid" id="A0A401H2M4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="208" mass="23079" checksum="600BF1942EB19FD3" modified="2019-05-08" version="1">MSAPVEITEDDCKVLDQMDVNLIPSSLENMFHGYYGEKDEGRIAELATIIEAIFPIIGGDSSDGIGLMSCDEAGFHDKKQSAGQIGAALNNLAPSTLSPVDETLDFLLSCHWNQFVGDLTGMKPLCTIVIIHGAPPNPDCLKRVIFRSMFQSYLFNAKRHQVRLFFFQMGNPDKLKGQDGHDLYIQTTNSATAFLWDLDENLKKDYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H389</accession>
    <name>A0A401H389_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1402820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619787.1">
        <property type="nucleotide sequence ID" value="XM_027763986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H389"/>
    <dbReference type="FunCoup" id="A0A401H389">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H389"/>
    <dbReference type="GeneID" id="38785791"/>
    <dbReference type="InParanoid" id="A0A401H389"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar sorting protein 39/Transforming growth factor beta receptor-associated" evidence="1">
        <location>
            <begin position="205"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="711" mass="78885" checksum="06B57FAF55B8CD8F" modified="2019-05-08" version="1">MSSRSRHASFLRGSVLVLGSDSVQSLLPSTLVSQVDALLESHRIEDAVNLAEQQRTRFQSMSMVDGREADELRYAYQRIGFQCLTETLFDDAGKHLFAGDLDPRLLISFYPELRGSLFGVNDSIDVFAGVSEHMPMEGSMDDIIINYSPHLPPSTREAPATVELRGILGLAAKDMLEVYLRKWRTKYGSKDAAVLPKSSAVRTVVDTVLAKLYAAAGKTAELDILIDEPNYIILPEIEPVLAKFQRYSSLCRLYRRCGEDNKLLDVWSKLVQGEWVDESVQDPLSSMFTLLNEKRDRTLIQRWGIWLTKRDAERALKLLTFLVSGKRKAEDDRSLLQQVQEVSPSAGIQLLEHLVLQKRSTDPDLHMQLAVTYVNQLLSHIADEAISKLWRAKASSYGSNPSDSSFLAYFSLTTPDSDSKRVRLKTVLFLQGSALYDPKVVLERLVPHEKLLRLELAIVHGKLGQHRTALSMLVHDLHDATSAEVYCTLGGEIIPVKTAQSLGERYDLQPWAALLVPPATAKTKPSAVPMSRPNTVDADLKKSLIGILLEVYMSGGEATADQTARFLNAQAMNLDVLDVLSLIPPEWPLRVLSTFLTRSFRRTLHARHEAQIVKAISAGENLVTADRTWRVLREQGAVIEEAVSDDEEGDGGDLGVDEKGVPASFDEKVELRGHEFDEAEQGNEGVVDIEVAPLKESVVVPDPGSEVEIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3C7</accession>
    <name>A0A401H3C7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1403450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619850.1">
        <property type="nucleotide sequence ID" value="XM_027764049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3C7"/>
    <dbReference type="GeneID" id="38785854"/>
    <dbReference type="InParanoid" id="A0A401H3C7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="127" mass="13607" checksum="C2245B74FE2A509D" modified="2019-05-08" version="1">MGLTPRLALAPPSPNCIAKSVLAATQLATYRLPASSLQFCYYIARASRNSVAGRPQTLDKHGLPHSPGALATVRESVELERVLTPSSPCSALIAPFASHAWRCERLFDADAPDVSRVLPPRLNDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3E8</accession>
    <name>A0A401H3E8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1403410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619846.1">
        <property type="nucleotide sequence ID" value="XM_027764045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3E8"/>
    <dbReference type="GeneID" id="38785850"/>
    <dbReference type="InParanoid" id="A0A401H3E8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="163" mass="18238" checksum="8FC6BEC25C5A0347" modified="2019-05-08" version="1">MKPGSRCFVRSMSMQNGLPAWTDWVEGEVEREVVLRLPVGVDVQRYTVRVGTVTNQYIPYLGEIQVPGYKPTSLDIFGHIERWSLLKGVFAGPFVVYGLRTYLPCYYLGEGHLSAITYSVYVDSGGPVGYRDTVQEVTELHPYNADTKVVLEEGGAIVWNPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3N7</accession>
    <name>A0A401H3N7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1500500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619961.1">
        <property type="nucleotide sequence ID" value="XM_027764160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3N7"/>
    <dbReference type="GeneID" id="38785965"/>
    <dbReference type="InParanoid" id="A0A401H3N7"/>
    <dbReference type="OrthoDB" id="2659442at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="598" mass="67002" checksum="0EB000F6C6B52D51" modified="2019-05-08" version="1">MTAEKAHQLLDPADKQNVLKAVNLIQELLKLKDHEQPPTLPSEAHRRHMLTFLARLLGCFVLPFISTSLSLAEQIRSLVTYAHLLAAMWIKHGTSFTTGALYADSQAIIKNLIFCILRLQLIDENILFYIILEGTDRLEALFSDCRTQDHSRNFDVCQLCDKLSISALLSYIFERNQDLDRGHRCLNLKDAMGVDHVNPKSWTGDVKVGHAEVASEWRKGRVEANNILREYFGPEACVDFDALFGREGYDLLRPSGSYVGVKYDPDDARTENPVEGSTVPVPMNVTPGSHSTDTAGDSDDRREAVDDSETFDDVPEGMDLDDFMPDTEDDSGTDKPSFHSDQFLLIEGKTYLKSSVVTSLLTSNRSRKVTMRTLRARDDIVKFGDIAACLVRVGQNICLGVLEITGFERGTDKGRLTAVKLEDLEKRDSDLHVTAQLLELVPQGSPQGDNSDHWFWTHQYIRFGARSQSERSTHNQHILTIPAFLVHPLGPSVVPFKPLEVAAAAADDDDDSDDDGDMFELPCTILEPQPQSGPYSGRKLQRMTWSLQDAQLNEILNYAWEWLSPDTEEVIRNVDLLPSVESASMPYKGRDRGFSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3T4</accession>
    <name>A0A401H3T4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1500750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619985.1">
        <property type="nucleotide sequence ID" value="XM_027764184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3T4"/>
    <dbReference type="GeneID" id="38785989"/>
    <dbReference type="InParanoid" id="A0A401H3T4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="80" mass="8702" checksum="B523244C87F8DA8C" modified="2019-05-08" version="1">MGQAVDPDRQLKQVKLSAQTPPLAAVVSRKTRCGGGCDIGPSWCTKHPSSSAQTVAQEILTHFAAFALRYLDRPVPYLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H432</accession>
    <name>A0A401H432_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1501820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620087.1">
        <property type="nucleotide sequence ID" value="XM_027764286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H432"/>
    <dbReference type="GeneID" id="38786091"/>
    <dbReference type="InParanoid" id="A0A401H432"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="334" mass="37815" checksum="085912E28CA713F0" modified="2019-05-08" version="1">MIPTSEISARNHSIVQRSDNPDSEFEKDEEFWFEDGNTVLISRDVGFRIHRGIVSRHSEVFRDLFTLPQPTNAEKVHDCPVVSLSDSPMELRILLRAIYNGQRYNRCEQAEFWEVATVVRLSQKYLMEELYEDGLACLKTCLTDDFNVWDRISRADDCSSPVMHFDFEDAIAAVNLARLTHTDSMLPIALYLCCQLDSEALVRGIVRPDGIVEQLSPEDLMRCIDAAVSLSARNTSRHLLLDVSPDCACRSICFPRLQQIIIRLFNTPDVLESCDVLSSADSTIDSFDGLCTECISCLKTEDLERRLRCWDELPSLMDVAVPGWGSGDESMTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4B1</accession>
    <name>A0A401H4B1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional activator HAP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1502600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620165.1">
        <property type="nucleotide sequence ID" value="XM_027764364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4B1"/>
    <dbReference type="FunCoup" id="A0A401H4B1">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4B1"/>
    <dbReference type="GeneID" id="38786169"/>
    <dbReference type="InParanoid" id="A0A401H4B1"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000099">
        <property type="entry name" value="nuclear transcription factor Y subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE89252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="150" mass="16470" checksum="D0EF9DB9FD8FFF02" modified="2019-05-08" version="1">MSDFPPAIAPQDDGTGVAPEPVQAPEPAPITEQEVGEYREQDRFLPIANVSRIMKSAVPGTAKISKEAKECVQECVSEFISFITSEAAEKCQMEKRKTIGGEDILYAMATLGFENYAETLKIHLAKLRQHQTTSTNNARSAEATDPRVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4E2</accession>
    <name>A0A401H4E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620186.1">
        <property type="nucleotide sequence ID" value="XM_027764385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4E2"/>
    <dbReference type="GeneID" id="38786190"/>
    <dbReference type="InParanoid" id="A0A401H4E2"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="336" mass="37499" checksum="0CEB54FA0A68E12C" modified="2019-05-08" version="1">MTNPYATDEPAPDLWFEQTNLAAVFIGCVAYGVHIVVYFACVYYLILEKKKNNWKWLAFVTMLFVLASINICINMHFSELAWIDDRNYPGGPLAFLMQQQALPINTLGNSATLVSTFLADGSLLYRVHVIWRRWYIVVIPTLMWLASTILSILTTVQAAQPASSLWASATLNFSIAYWSMSMSLNILLTILLITRLFWMRRKIINTPLGKKYGKTYTGIATMLLESALPYGLVSLVFIILYGLGNTAENLFIPLASQIACIAPELVILRVSLGRAWSNETVTEANLSALRFRDETGRSTTAGGTDLTNDLSMMTFKGGSYPNLRTKASDMTVNRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4F7</accession>
    <name>A0A401H4F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1503250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620230.1">
        <property type="nucleotide sequence ID" value="XM_027764429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4F7"/>
    <dbReference type="STRING" id="139825.A0A401H4F7"/>
    <dbReference type="GeneID" id="38786234"/>
    <dbReference type="InParanoid" id="A0A401H4F7"/>
    <dbReference type="OrthoDB" id="3038857at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12569" checksum="632980E361207969" modified="2019-05-08" version="1">MENDDRGAMEGPTVLGEVVLVKCPARGYPKQLHELANFIGTPDLSALIQQFLYQQLHPKLNLSLAEIDADDYPQFEDRVSVFLSVVTMYYAPSDQSGVSGMYRECIRSVPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5Z9</accession>
    <name>A0A401H5Z9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1701380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620726.1">
        <property type="nucleotide sequence ID" value="XM_027764925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5Z9"/>
    <dbReference type="GeneID" id="38786730"/>
    <dbReference type="InParanoid" id="A0A401H5Z9"/>
    <dbReference type="OrthoDB" id="3133286at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="221" mass="25268" checksum="EEF27256B3EDE862" modified="2019-05-08" version="1">MSAPTYDEIRDVARKAVDIFGQRQLRCCLFGSTACALYGTSRCPNDVDLVVLDPESDPEDLKQMLVDGDVNFYLVPSKDTNATYQVLWYILPYSPDGQRRMCKVDILIPGGDLGIPFVPAEFLETRHNFPVMPILPLLLLKLQGWVDHRSAERWSVQEKQHADVEDIEDLIIIACDQRVHTSICTWLPQEFFEAAEDRVEDYAGQFPLSSLYWYTLGFDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6G1</accession>
    <name>A0A401H6G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620884.1">
        <property type="nucleotide sequence ID" value="XM_027765083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6G1"/>
    <dbReference type="STRING" id="139825.A0A401H6G1"/>
    <dbReference type="GeneID" id="38786888"/>
    <dbReference type="InParanoid" id="A0A401H6G1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="636" mass="67365" checksum="B4DB5E3ECDC69675" modified="2019-05-08" version="1">MAQTEVEGLKVSTKKSGKRKAKESSDEEEVPTVKPPKKKCVTKEYKTKEFIESEDETPAPPSNLPAKTAGDSNNGVAKTNAPAKPVKQTMRITASPHVAPKAKVKGKAKATAKGKATAKAKVTVSQKDMWKKTSTRVSDFMWAHATDSLVPCIGCQEKEWPCKLNTANFGRCLECAARGCEFQEMCAALVVEGKPLPTSPPPYDVKVDFDEPDGAEPMVMGASKRKPPKKTKTRNAVASSSKVKGGEEVEATKQKVTVTPNEANTEGEASVEKSSKSKRATKSATTTGAVALSNSGEVANSGKVSKSGAPAKSGAVAKPGEGKKSGPKPKPVRSQNSGAQDGGEVTRTSVREADEVPPAKSVAKEGGQTTRLAMGGRSGPMVPVITRKVKASAQKAAAKMPLAEGDGMEEAARLAIEAVRAMAFQTGPAAPPQASSSKRMLTPVADEPEDAPEYQAEVAEDERASLEWPHDDRRRSLLMPHEMSAGAAEVAQEVTPSLEISKASKGAKSSTLAKAGHLDEGRRPAKRGAPLDRKAAKKEAEAKMDAKANHLRAVPPTSKAPHLRDVQRVSTGSPTPVNEGDTPSGEETLQSSNDDCTNCAELRQEFLVHKDGMEVQFQERMADLNTIKAEITAVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6V6</accession>
    <name>A0A401H6V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1801370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621026.1">
        <property type="nucleotide sequence ID" value="XM_027765225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6V6"/>
    <dbReference type="STRING" id="139825.A0A401H6V6"/>
    <dbReference type="GeneID" id="38787030"/>
    <dbReference type="InParanoid" id="A0A401H6V6"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="14"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE90113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="230" mass="25802" checksum="AF6715AAF8D22F4B" modified="2019-05-08" version="1">MSDLLTMSETVSAFFYGTLLHPSILRRVIGHDGAQLEICPALLLEHTRHKIKYADYPGVIPYTKSRTLFSRELTPEERTVRGTVVTGLKLHDIDLLDIFEGREYTRQSISVHPLGSFTSLESAAAYSAVPMTSPLLPPLDALPGPLSAQTYIWARPLTELTPELWEYADFVRDNAWKWVGDGSRNNADYAEVDRRRAMNGNIVSTETVSTDSEDHRKTVMETFDEGTVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H749</accession>
    <name>A0A401H749_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_2000090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000020">
        <property type="protein sequence ID" value="GBE90266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621179.1">
        <property type="nucleotide sequence ID" value="XM_027765378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H749"/>
    <dbReference type="GeneID" id="38787183"/>
    <dbReference type="InParanoid" id="A0A401H749"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="57" mass="6251" checksum="59E2C74D97C35C79" modified="2019-05-08" version="1">MKDVRNGIGKGDSDVDVADVDMVMVMVIVMNGYMNDDKTWQAVGTWTWLGTMMAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H760</accession>
    <name>A0A401H760_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1900910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621155.1">
        <property type="nucleotide sequence ID" value="XM_027765354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H760"/>
    <dbReference type="GeneID" id="38787159"/>
    <dbReference type="InParanoid" id="A0A401H760"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE90242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="200" mass="22132" checksum="969D78FD6C617BA2" modified="2019-05-08" version="1">MDISVEDERLSPIPVAGSSVDSNEESKGGEARRLPPDELGRVAKNMEPREAAYEIQFSAVTTQIRIIRHTPLKYRWFHSTGSHPVKFPPEFPPQASVDAYDVYTHSWPSGVAPRGMTQQMWIWKQHLHNSSAAWLPVSVGYYCETGRFTGRSLVLTDQGVPSWVGKLTLQRGYKHVGTGLDDGANPVQPGDASKGKSKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G541</accession>
    <name>A0A401G541_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0101550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608195.1">
        <property type="nucleotide sequence ID" value="XM_027752394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G541"/>
    <dbReference type="STRING" id="139825.A0A401G541"/>
    <dbReference type="GeneID" id="38774199"/>
    <dbReference type="InParanoid" id="A0A401G541"/>
    <dbReference type="OrthoDB" id="3256367at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="30577" checksum="A1B7B67C1CD9E563" modified="2019-05-08" version="1">MDTCSPEIHTYVFSFACTDSGATGRSLSLVSRYVRQVSASFKWYSPSISGKRQARQFVDVLHKTAIQPRISHLFLSTRCSCQTADAWWEEPEVCQQWSELQDTILHFAALTLITLTFASFDSPYFGAECIYRLLKVPFHILTELSIRVHSMPNRIKSILDDAYGLYGRKSPSGVLQTTARTTIRRLHIACLFSEECDTEGIRDIVQIIAPNLTHLRLSALEQVTCSWRIPRCEMYAPRLPQRPFRRSPAFLPFPELFWQYMATDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5P7</accession>
    <name>A0A401G5P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0103650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608403.1">
        <property type="nucleotide sequence ID" value="XM_027752602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5P7"/>
    <dbReference type="FunCoup" id="A0A401G5P7">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5P7"/>
    <dbReference type="GeneID" id="38774407"/>
    <dbReference type="InParanoid" id="A0A401G5P7"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="350" mass="38344" checksum="FCC662C21E1F0E0F" modified="2019-05-08" version="1">MSQSPQGDIQERIAAARREAESLREKIRARRESSADTSLRAMAAEVAALPRIVMRPRRALRGHLAKIYAMHWATDRRHLVSASQDGKLIVWDAYTTNKVHAIPLRSSWVMTCAYSPSGNYVACGGLDNICSIYNLHSKEGNNVKGARELSAHSGYLSCCRFLNDRQIVTSSGDMTCMLWDIEAGVRVVEFSDHTGDVMSLSLGPNQNVFVSGACDATAKLWDIRSGKATQTFTGHESDINAVNFFPNGDAFATGSDDASCRLFDIRADRELNSFTHDNILCGITSVAFSISGRILFGGYDDWTCNVWDTLKGERVGVLTGHENRVSCLGVSADGMALCTGSWDSTLRVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6A4</accession>
    <name>A0A401G6A4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD-dependent histone deacetylase HST3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0105580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608590.1">
        <property type="nucleotide sequence ID" value="XM_027752789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6A4"/>
    <dbReference type="FunCoup" id="A0A401G6A4">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6A4"/>
    <dbReference type="GeneID" id="38774594"/>
    <dbReference type="InParanoid" id="A0A401G6A4"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="503" mass="54902" checksum="108A129BF9C0D84F" modified="2019-05-08" version="1">MTVTLHLDLVSSDSSTRRSLSNLSLAVAKCKKIVVVTGAGISCSCGIPDFRSSDGLYALVKQQYPDVILKGRDLFDASLFRDPTSTAVFYTFISQLKRSVDSASPSPTHRFIKTLDSKRKLLRSYTQNIDALEEKAGLVGSSSQDVKAAGKGKAKIKVKAVRNVQLHGDIHRVRCNFCSAELPCAEEYLDLFDTGVPPDCPECTSRSNNRVARSARALKIGKLRPAIVLYDEPHPLGDDIGSMQSADITRKPDMLIIMGTSLKVHGFKKLVKDFARAVHDSAPSSSSSSPQNAKSMAGKVIFVNKTAPGSEWNGIIDYHVEGEADRWVNKVVEDWKKMRPSDWEIQKTLVATEEVDGGLLTVTKEITNTLATKGKGGRGKQLAEWENVPPMEDAAAAPSLPQPPSSPGKRRQDGCHYSVESSPSKKRVAGDRFEKAGLEERGLLFVDSTNNRHSAKDSDDEPFDMGETPMKPTAAKRTKARAPKMKAEVVLPARKAKRAVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6J9</accession>
    <name>A0A401G6J9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0106610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608692.1">
        <property type="nucleotide sequence ID" value="XM_027752891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6J9"/>
    <dbReference type="GeneID" id="38774696"/>
    <dbReference type="InParanoid" id="A0A401G6J9"/>
    <dbReference type="OrthoDB" id="3149711at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="66284" checksum="422DFA838C2ED5D1" modified="2019-05-08" version="1">MHHAAGVVSQRVVSQAGTEAGSSSCSVASEVTPINQPLASRLRSANLSQCENDPASSDNQASLCLPVEDDCSLKDSTGVHLPETIPPARLAGLSQKFGDARTIDADPLSSDDMSLANSGLDPAPPTQTDPPWSQLDVSHSGPHSPLASVRSDPFSDTATVPVHGSPTPRELAAAAPSAHHSNPTISASILSDPVVPSQRSAVSLPNPRSPFELRYNLFRLLSTVPRPPPRRLLAYHAAFPHLHSASSYNILMAVAIRNANFGTVDLLLKRMKAEGIRPNLDTRKLRVRWLVRVGKWDECWDEESARAKEEGQGMPLTVWLEFFDTTKRGAIRRRVCRDSRDLQVLDRSDSGVTAQRHRILMQSFPSVTTQDWASTSPRVVFNFVRAMIRAGERSMAAKTTRVYFDSLPPQLDDARRSRCLEIIHLHMAPRGNRDLSEHYRVKKDLFAFLRMHRTFEPTSTTLFMLLRTLQTTTKCGSLALSTVQNFVSRWGAQILDRRVRRRLVSLALKQNNLRLMKALTLYLERLGASRKEEQEALGRKSRRRALSLTDTLRFTRRGTEGWRWRLLRRRLWRFEHRTPSASSNKALTHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6Q3</accession>
    <name>A0A401G6Q3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0107270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608758.1">
        <property type="nucleotide sequence ID" value="XM_027752957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6Q3"/>
    <dbReference type="FunCoup" id="A0A401G6Q3">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6Q3"/>
    <dbReference type="GeneID" id="38774762"/>
    <dbReference type="InParanoid" id="A0A401G6Q3"/>
    <dbReference type="OrthoDB" id="18703at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109">
        <property type="entry name" value="PROTEIN FAM207A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31109:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN SLX9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE77845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="203" mass="22941" checksum="25848BA92137901D" modified="2019-05-08" version="1">MPKERRRRIGGHEPSVRLPNRHFAVQENAVEHVDLGAQANASATEIFSSMAEQDAPQTNMKKKEKQALKHELFLKRLESSRSPYSKSHERRLRRKEKEQVAGGMSDMKAAISAVESIIPDAVVDSTEMPATETAEERPKARKRVGKIGEGKGLPLSKSQRKRVLQTERLRIPMILSTPEFASNPFQTIRIHAQNTLLKHRPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6T5</accession>
    <name>A0A401G6T5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0107620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608793.1">
        <property type="nucleotide sequence ID" value="XM_027752992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6T5"/>
    <dbReference type="STRING" id="139825.A0A401G6T5"/>
    <dbReference type="GeneID" id="38774797"/>
    <dbReference type="InParanoid" id="A0A401G6T5"/>
    <dbReference type="OrthoDB" id="3222238at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49211" checksum="A42B8CB096452D3B" modified="2019-05-08" version="1">MQIKDGAFSLVSAIDPHEWTVFQRYAKRIKVLFYTPSRIIHPSVFLHLHELSQGVPLLPALRHLTWQRARSPDPAATLFSSPSLRVVDISLHQPDWGLFEDVHIGEDGEVHAVRILLHNIAAEAPSLESLKFSGVLPSQLASFIIQFRHLRHLDFSMAGAVDVETLRALSAIDALVYLNIYMGGVAENTMLSEAAFQSLESLTVSGSFDSIGFVLGSIQSTVLHDISIVANIPHAPEESLFYSVLLQNKFSRSLRRLHMRLPVTTCRNESADAITIISPLLHVKGMENLHLEFDGRMLLRDKDIDSMASSWPYLQHFYLMHRSVDCDPSLRSLVSFATHCLNLKELAFVVDARPPLSATPTLTTPHPLRSLRLLGNVRLDKDSASIAPFIRSLFPSLQHFEAYAWDPQANATWVNIQYAIPSLKRKKTGRKTRKLVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7J7</accession>
    <name>A0A401G7J7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain-containing factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0110330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609063.1">
        <property type="nucleotide sequence ID" value="XM_027753262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7J7"/>
    <dbReference type="FunCoup" id="A0A401G7J7">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7J7"/>
    <dbReference type="GeneID" id="38775067"/>
    <dbReference type="InParanoid" id="A0A401G7J7"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05500">
        <property type="entry name" value="Bromo_BDF1_2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="245"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="445"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="622"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="125"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="742"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="772" mass="84543" checksum="06D830657276C0D7" modified="2019-05-08" version="1">MLDAPLSNGVHHINGHSTPDSPIDSPATPVDNSTAPDVKIDVDYTEGESDVRHEPMPLKLDKLDNASVLPQVGTPADPATIPIEPPKGTPPPPPGQLLEDVRVAEQQPLPTTDSDVVMADAVEHPSTAHGLPNGHALDSPAATPVSSIPAVSSSETAVDSLGATSPYPNNKHANEHDDDDDHKPPAKRARKYSDADKASLANTGTPPPASASPDVGTHAPLPSTTTSTLSPAQWRFATSTIRTLKKVKEAVPFLHPVDTVGLNIPHYPTIIKHPMDFSTIDRKLASSSPLKPDSNPANPRYYNADEFIADVRLIFSNCLTFNGPEHAVMLMGKRVEAVFDKQIKQMPPAEERKPVIVKKVATPPPPPPAKKVAAARRPSVNVPVIRRNDENVGRPKREIHPPPPKDLPYADIPKKTRKVKRAKNDAHAEQLKFCDKLLKDLQRKNHYSIAHPFYEPVDYVKMEIPSYPKVIKKPMDLSTMRKKLQNGEYLTAEKFRDDFKQMIRNCATFNPPGNPVHEAGKSFDRLFDEKWANLPSLHSHEVSEDEYDDDEEDSEDDRARMIATMENQIQTMKSSLDSLKKKGKELKKKEKKKEKAVPPVASTSKHASKPGKAAASNGRKKGKKPITDDDVLSFEQKKDLSDTISKLDGAKLEKVIQIIHDGVPEIRDSTEEIELEIDLLPASVLTKLYNFVIRPMRTPATKRSRTGKGTGTGGLKRKSMDEDVEAAKIRALEARMKLFEGGQAGASDVAPGEESEHSSAESSSESSASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7U2</accession>
    <name>A0A401G7U2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multifunctional cytochrome P450 monooxygenase af510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0111100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609140.1">
        <property type="nucleotide sequence ID" value="XM_027753339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7U2"/>
    <dbReference type="STRING" id="139825.A0A401G7U2"/>
    <dbReference type="GeneID" id="38775144"/>
    <dbReference type="InParanoid" id="A0A401G7U2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE78227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="533" mass="60039" checksum="B4D5394D698A3B55" modified="2019-05-08" version="1">MAPTFRIHIAWAAFIDLPTVPPSPSAQRDLMVSFLICFILYAVFSKHAVRHLPLPPGPRTSWFGSVELPKTYPWITYAQWRKTYGDLVYIYVFGNPVVVLNSARVVNDLLEKRSSIYSSRPFRSMVTQLMGWDWLFSTIPYGPWWKKHRAMFHQHFNAANTSTYHPVMLRETRVLLRNLTDSPDNLDHHIRRNAAAIVLSVAYGHQVAPEGDPYVLLADQAMNTLGLAGIFGTYLVDYIPPLRFIPAWMPGAGFKRQALEWRKLNQAMLNAPFKMVKERMASGNAIPCITAAAVEEWLQSGRDPEQEKVIKGVAATSYAAGADTTVSAVLSFFLAMTVYPEVLERAQAEIDKVVGRDRLPDFSDRDSLPYIDWIVWECLRWNPVTPLGIAHSLTEDDVYEGKLIPKDTTVIPNTWAILHDEATYPEPYRFFPERYADNLKNTELGINEPPLAAFGYGRRICPGRWLATDSVWIAVATVAAAFNIAKALDEKGVPIEPEVEYTSTLLSHPKHFQCSIVQRSDAAAALIAQTSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7X2</accession>
    <name>A0A401G7X2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="17">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">SCP_0111450</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="17"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609175.1">
        <property type="nucleotide sequence ID" value="XM_027753374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7X2"/>
    <dbReference type="FunCoup" id="A0A401G7X2">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G7X2"/>
    <dbReference type="GeneID" id="38775179"/>
    <dbReference type="InParanoid" id="A0A401G7X2"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 17" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="110"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="GBE78262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="353" mass="39207" checksum="7146744F4972CE2D" modified="2019-05-08" version="1">MPNRLQVAFIASFLITFFSLVAVSRFINSKLKAAGYNISDLILIGLPKNRTEQGANDGYIPPHTTPGMSAPDFANSSYVQLLALALTVFTSIFVFLKFGNSKRKPALDPQVWKEFPLKQKIIVSPNTALYRFALPNPEDILGLPIGQHISVSAEINGKDIMRSYTPTSSDDNLGHFDLLIKSYEKGNISRYVSLLKIGDSIRVKGPKGQFRYSPALSREIGMIAGGTGITPMLQIIRAALKNARDRTKLSLIYANVNPEDILLKRELDELAAAHAHRFRVYFVLNNPPVDWTGGVGFVSKEQIEKHLPPSNHDIKVLMCGPPPMMSAMKKHLAELNYPTPRTVSKLDDQVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G7Y8</accession>
    <name>A0A401G7Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0111690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609199.1">
        <property type="nucleotide sequence ID" value="XM_027753398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G7Y8"/>
    <dbReference type="STRING" id="139825.A0A401G7Y8"/>
    <dbReference type="GeneID" id="38775203"/>
    <dbReference type="InParanoid" id="A0A401G7Y8"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16039">
        <property type="entry name" value="PHD_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="912"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="457"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="714"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1233"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="538"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1239"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE78286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1279" mass="138865" checksum="0E1439ECEC5C1785" modified="2019-05-08" version="1">MAARRLAISSLLCPDDSPPPSASIPSRPSPSPVQSRPILESRSSGVRAHDRPLSNIEHPVHLWRHTPSPHSEDDSPPPTTQSWSAYRHRSPDRVAGYADTRPAFSVHGFDFTDHAGRRPPLQAESSHPQPSLRVSDPYHQHSYSPPSTSYSTRPSSSRSEHSDSPSTSQPYAIQPPPHSPSQSPASIYNLLLHRQASESPVLSSRHASASPINYYNPVTQPESSYRTPQLSYHQVAQATVQGRVLSGPASPPLPFSTSHQLAQRVPQPRPFPPPHSALALSDPVPTVRNTSAAALPNILNSYSPPQRSSGLGGLEALVQAATEERRRLSGEISSSEAVRRNDSPRTSLSPVMGRASAQPEAAQQRQLQQPTPSPQVSHPALGLDIPALVSHRDGEPPLKRRRGSGVAPFDVPVMAESHHHSSLTGASSVSPLEVRSPSGFQFRSEVVQAPAPANIVGLGEGTQRSPLFGPGGDGGGAAGSTESALSSYQAPTAATPPAPSLQPEDSGPQHSEEVFAGPGGQPEKKEQKRRERPAHKKEKGEKAKGGEKGKAIPRDEHGRREAKLQHSQRIETREEDPHEWLLEHYAAASPPRRTRALSPVEDKKQPPSYSFPSHARDSKEGASPTEDPLPHTGRADSKKHKYARSRTRTPTPLAMLEQELDAPNEVAPFSSAKAEGSETSLSLELDLAADAVPDDKSAGRDDFMDLDVEDELLSLLDDKPRPSHSRPKHVPSAHSKHTHSSKRTSDARHAHLTPDVQRESMPPPALTNVGTSREVALTGPAKTKGSGVVSVASHHKKKDISEKPMPKPKQPPKTKPKPAAKPKVKATGSKDGATSALSPASASLTPAIPAPMTKGKKTAPPPGLGSSAPKRSVSAAAGTSRSRSTSAMPGGSVGPEGKGQVDGEDGADTDDKLYCVCKTSYDEDRVMIACDRCDEWYHTQCVNMPDVEVDLVDQFICPPCIESNPHLSLRTTYKRRCLYGLKHPNPSSPSACHKPARGAFSKYCSDECGMLYMQSRIDAWGGDKRRLWESVKSADKREGVAVCVKEVKDVQETADAAKLNGNHPMPAERLSDLPVEVVMPTKTKVERDMAHLHVQLERVAQRRDELKKQMEVVVWREKLVEYATARAETLDECGWDQRLCFGDEEYAEFGAGVLESYEELDQQGAEVEGEHMQVDGAPEEGEWWCKGKKKCDRHAGWQKLRLAEVSFEKETMETALLQLTTGEREIRRQIEDVIDPKARTSSMGTGSPLQPLNGKASSNNLSHSKSNGDQVKKGKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8L8</accession>
    <name>A0A401G8L8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0113910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609415.1">
        <property type="nucleotide sequence ID" value="XM_027753614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8L8"/>
    <dbReference type="FunCoup" id="A0A401G8L8">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8L8"/>
    <dbReference type="GeneID" id="38775419"/>
    <dbReference type="InParanoid" id="A0A401G8L8"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000524">
        <property type="entry name" value="Cell division protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="3"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE78502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="411" mass="45964" checksum="7B2A491CABB22AEA" modified="2019-05-08" version="1">MNYVQLEKLGEGTYATVYKGRSRTTNEIVALKEIHLDAEEGTPSTAIREISLMKELKHVNIVRLYDVIHTETKLVLIFEYCDRDLKKYMDVHGDRGALDPVTVRSFMYQLLKGTAFCHENRVLHRDLKPQNLLINRKGELKLGDFGLARAFGVPVNTFSNEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCIFAEMISGVPLFRGRDNQDQLLHIMRIIGTPDDRVLRKIASEGQTENQGPQKQYPRYPKIPFHQVLPKASPQAIDLLERLLQFDPAKRITANDALSHPYFTTAIPYPIPPVPGAMGPPAFNYPHPHAQQMQQQQQQQLQAQAQAQAAYVQATQGMLAHGQAQMFTNPDGRMAQAHVAAQAQFALAAQAQAQAQAQAQAQVQGAQQPAGYGMQYPQYAPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8R9</accession>
    <name>A0A401G8R9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydroorotate dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0114220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609446.1">
        <property type="nucleotide sequence ID" value="XM_027753645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8R9"/>
    <dbReference type="STRING" id="139825.A0A401G8R9"/>
    <dbReference type="GeneID" id="38775450"/>
    <dbReference type="InParanoid" id="A0A401G8R9"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="153"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="353" mass="36296" checksum="35353D153CCC4022" modified="2019-05-08" version="1">MVRLHTLKIDPPLLNSSCAWASDLEQLRELYECPSTGAVTTRTATLDGFEEGPGIGVVFTTDGLSTLNTYGYSPHPLGTYLEWIYALLTAPASPTRPHRKPFILSITSALPAELTTMLTQIQALRSRLRAALARDGAMNGYADAEDDPAALLAVELNTSCPNIPGKPPPSYALHTLAPLLAVLGAFARADLSLALGLKLPPYPDPSAATGIVACLHEFTYTSAGEGPLSPFAFLTCTNTLGSSLLFASQVQSEFEPTSPTAALAPALPPGLGGLGGALIHPLALGTVFALSRALAAHPSAAVRNVGIIGVGGVLDAPGARRMRAAGATAVACATALGARGVGVFAEIRPGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8Z5</accession>
    <name>A0A401G8Z5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0115170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609541.1">
        <property type="nucleotide sequence ID" value="XM_027753740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8Z5"/>
    <dbReference type="STRING" id="139825.A0A401G8Z5"/>
    <dbReference type="GeneID" id="38775545"/>
    <dbReference type="InParanoid" id="A0A401G8Z5"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019224331" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="58"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE78628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="581" mass="61581" checksum="D580BBA270905064" modified="2019-05-08" version="1">MLAGLAFLSLSSLLATGHALKISVQRRAAGHSDTVVVTNPANANNVGFSSAWQAYGRYTITVYVQGQPFQVHLDTGSSGLWIDTSNVTIDGFIDTGYNSTDIYVDTTESSGPIVMANVSVGQFLVAPWSLLGVASSDQLCEVNAMDSDATSAGADVGLLGIGPPHASQIYGRLYNSSYNGAPFLNNVFNYYPDEQAFITLLLTRSNIGITEGGVFSISELVVDYASIIDTPKLLVHSDTAFLTFMDGIYVNGEFLTGHSIGVNGTSANAIPNENQTLVVLDSGTATIPAPQYYVDAIYGNIPGANFSSTVNTYEVPCSAKLNISMLFGDILIPIDPIDATMVNVNDDGSVQCFGTFTYMFDGTPLALYMQVLPLTDPDAAWANFDALNLQRIGQLEWQQMQANANSTSSYTEAASMSVTYSLAPPSAVRTSISSVPSSVPSMSVFPSSATPSSSPSSPFSNSPSSPSSNSPSSNSANSSPATPSSTPGSTVRLNADLASSLGDSSSVNLSGLTRNSYIIMGLIGGVLVLLIGVLIKLVKNSRNQQYRAVPNIIRPPMHFNDKPYELESEDLMMPYDDPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9A9</accession>
    <name>A0A401G9A9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7223 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0116470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609668.1">
        <property type="nucleotide sequence ID" value="XM_027753867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9A9"/>
    <dbReference type="STRING" id="139825.A0A401G9A9"/>
    <dbReference type="GeneID" id="38775672"/>
    <dbReference type="InParanoid" id="A0A401G9A9"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019249109" description="DUF7223 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="2">
        <location>
            <begin position="288"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="534" mass="55867" checksum="0F011B59E9F481D7" modified="2019-05-08" version="1">MVRGIFLLLPSLLSVVVHANDWSEPCFGECSYDISGSGVSGIVYISGSSSAVSDITTAGGWDILDCDSDSTAQDIRAICGSGNSTCDHLYEGGAIGTIVRLPENCTQMPFARISDTWDHEDQSMPAEKRSRLFYRQGSAVVKGFSLDTNFSAIDPSQYGNVSFWVQGTSMPGASFASASTSGKRALHERSSFGWVQQSLNNISQFSKNVSENVLPINVQKQGVLFNESIACPAIGNIPPFAADIAVAIDAQVDATLQYGVAVSGTLVPPEMSEFGLFAGLSGSIDGTLIANATAATTLSTGIIPLLQVGIPVLDIPGILTIGPTFELNVEATAMLDVDLNLAVGLNYNISNAELYFPPSSNSATSGGIFMPGDTNVQLSASPNVTSQTTLTAHLIPTVAFGINALSGVAQATVDLDLDASVTLDLDLQASMSSNTTGNTTGSAFGGSVNITSEFDVNAGADASFLAFFDKSTTVTLFSKTFELFQENFGNAAAKRMARRAPRPLRRSSLTCPVVALETIESIIDIEKAASSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9D7</accession>
    <name>A0A401G9D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0116510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609672.1">
        <property type="nucleotide sequence ID" value="XM_027753871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9D7"/>
    <dbReference type="STRING" id="139825.A0A401G9D7"/>
    <dbReference type="GeneID" id="38775676"/>
    <dbReference type="InParanoid" id="A0A401G9D7"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="182"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="407" mass="45538" checksum="73D69D652252AEBD" modified="2019-05-08" version="1">MPVTHEEAIRYLSDEYDTFAGGSDFRVLHLSGILDYFLGMSIWHTLMHRSALCYVPSELQAQFSVTSLIRLTGCTHLAVPLDVSAVVHEEVEKMAANSALAQKKSSLQTLIVPCLSSANWGISSLSHSKIRLMVGDDPSRVKPSPPKPAEISVLQRKPDTDLTPLRVLELIPLGTVIHDLGTRVVQITDDLVVKYGPSVRYVEALNTLHVLERTDIPVPDVYLVFKQGDATYIVMQFIRGRTVQSCWHMLDDSQHQHVASELARYLCELHASSVSTPSKRPGPLDGGKCEGIWFTLYGAGPFATYEDLVCWLNWKLALSGAPTNRQFTTDHPLVFTHQDMSLRNLILDDVNKLWVLDWDMAGWYPAYFDYTCIASDIGTPAVPIPLGWSKTILSHLPDYQENYRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9H6</accession>
    <name>A0A401G9H6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0116920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609712.1">
        <property type="nucleotide sequence ID" value="XM_027753911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9H6"/>
    <dbReference type="GeneID" id="38775716"/>
    <dbReference type="InParanoid" id="A0A401G9H6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="8105" checksum="E198A2D690E56FE7" modified="2019-05-08" version="1">MHLFAEVEERGPAASLSLRAPRCNSGALHPPSRSQRPLAGPPPLSAPFLDPLPISLDARRPIAANDAPVSSHRPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9N1</accession>
    <name>A0A401G9N1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0200400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609756.1">
        <property type="nucleotide sequence ID" value="XM_027753955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9N1"/>
    <dbReference type="GeneID" id="38775760"/>
    <dbReference type="InParanoid" id="A0A401G9N1"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="73" mass="8222" checksum="6C5CB6E60B8E3F0C" modified="2019-05-08" version="1">MREVGVLGPVSYAAGVRAPVIGMWCVSFELCRLIRIRPFEGLRATGGAQVSHDRACMWGCREFWMHRELSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Q3</accession>
    <name>A0A401G9Q3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Reverse transcriptase-rnase h-integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0200840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609800.1">
        <property type="nucleotide sequence ID" value="XM_027753999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Q3"/>
    <dbReference type="STRING" id="139825.A0A401G9Q3"/>
    <dbReference type="GeneID" id="38775804"/>
    <dbReference type="InParanoid" id="A0A401G9Q3"/>
    <dbReference type="OrthoDB" id="2442328at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF440">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="210"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="447" mass="51562" checksum="AB2028889874249E" modified="2019-05-08" version="1">MADDTEHGELPAVRNDTEPDDPPLEPSMDQFDDNDLVISYIAEEPVIGIFEPIRKESPLTNEESGTAVFTIRRGPTIKRMTHSTRSPLFCNTQNTVFYKPSSKSQELAQQAHKEASAVDKPKTVEELVPDYLHDLKSVFEKKAAERFPEIRPWDHAIDLKPDFIPRNCKVYPLSLKEQGAMDDFLEENLRKGYIRPLKSPMASPFFFVGKKDGALHPCQDYRYLNEGTVKNAYPLPLISELMDQLKGASIFMKMDLRSRYNNIRVKDGDQWKGAFKTNHGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNNLEEHHIRTRCVLQRLKDNDLFLKPEKCFFDIKEVEFLDMIIRENYIGMDPIKLKGIAEWPKPSTVKGVRSFLRFGNFYRKFIANFSDIAKPLTNLTRTAAGSPPFEWTMECQTAFDTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Q9</accession>
    <name>A0A401G9Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609811.1">
        <property type="nucleotide sequence ID" value="XM_027754010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Q9"/>
    <dbReference type="GeneID" id="38775815"/>
    <dbReference type="InParanoid" id="A0A401G9Q9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="112" mass="12155" checksum="BB1CAE80555526D4" modified="2019-05-08" version="1">MRRHFRTHGPDAISPILPPFGSLVVGDHASPFPPFSSPPSTYSGRSDYRPHVYGSDMSYGSDSDCEDGSDQGALSDGDTRQDILEKTNVSFSRIKLGSYSSYSDSRAAPRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA46</accession>
    <name>A0A401GA46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0202280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609944.1">
        <property type="nucleotide sequence ID" value="XM_027754143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA46"/>
    <dbReference type="FunCoup" id="A0A401GA46">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GA46"/>
    <dbReference type="GeneID" id="38775948"/>
    <dbReference type="InParanoid" id="A0A401GA46"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019025318" description="Pre-rRNA-processing protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19639" checksum="FB1AB060D4459391" modified="2019-05-08" version="1">MSSSVLFARGVIARLAIWPALRIAIAQAWGGPSSIAKSNWLASTLVDAFEQEDPVPDVAYVELMLLQIMEDEFDAVLEDGSAEEVARDVVQLWDEAAVGRTVMVLAFEEQAEKVKGKQVQAEEGAADDSDREDDDDDEGENGEDDAPTLLDVQQRPRKEVLEVDQDGFTIVKGHGQSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAD5</accession>
    <name>A0A401GAD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0203250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610041.1">
        <property type="nucleotide sequence ID" value="XM_027754240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAD5"/>
    <dbReference type="FunCoup" id="A0A401GAD5">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAD5"/>
    <dbReference type="GeneID" id="38776045"/>
    <dbReference type="InParanoid" id="A0A401GAD5"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF46">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE79128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="329" mass="35682" checksum="4A1A30ABEF694BBA" modified="2019-05-08" version="1">MLRGNSVRILTGNSHPELAHAVAERLNVPLTPCKVKKFSNGEIGVTISESVRDEDVFIIQSGCSDVNDNLMELLILISACKGSSARRITAVIPCFPYARMDKKDKSRAPITAKLVANMLAVAGCDHVITMDLHASQIQGFFDFPVDNLYSEPLMIAYIKRHIEDWKNGIIVSPDAGGAKRVTAIADKLGVEFALIHRERTGNSAKSPEKMEVLVGDVRGKVAILVDDMIDSGVTLILAARSLKENGAEKVYALISHGLLSETNMNAIQELPIEELVVTNTIPQEQHSVGCAKLVTIDVSPTIAESIRRTHNGESISLLFGDWTGQGVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAR9</accession>
    <name>A0A401GAR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0204380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610154.1">
        <property type="nucleotide sequence ID" value="XM_027754353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAR9"/>
    <dbReference type="STRING" id="139825.A0A401GAR9"/>
    <dbReference type="GeneID" id="38776158"/>
    <dbReference type="InParanoid" id="A0A401GAR9"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="493"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="809"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="964" mass="102078" checksum="BC8856C14CDE4B57" modified="2019-05-08" version="1">MDPMTRSPALNPASTPFFPGGMRGGEDDGRLGSSGLAFRLSTNREQQYSTSSSLSISPSDYRSVRSSPSPSQDDRGKLDVTLQFNPAGAGSRYYPAINTTEANRAHSIAQKSSVNDMTLSSNLGGSQSGSVSGSTETTPEGEETPGPSSSNGQLAPGNSLHGNNILGRGQHIVTPPVVLDTGASKSSFIHAPFASSSPASSLDSGSHFASSADLSSSFEAQLRASPFIHEILDRLARCEYSTRAIQRDLGDVNRKVDILVEKALNANTNGPPEFKDPFASTSAVTSSNGFFSPGLNPARSSLSASIAPNQTAPTDDITSISSRLNTLTTSVGQLLALQTQQIQATSGLQSAQLLGSGIQQGDLSSNQTLSQAVTGSILGHNLSNRPDIRSGPRIPNPPMRTWSAGNLDIPLRATESPAGFLGRQDSIFRDKRRSVSGLLRRDSVGGESLSSTSSRDGGPIITKWEQLSLAPELLRSLNTFGVGPPNKIQQRALPFLLRGADIIAQAPPTQERIAAYVIPAIHTALIHSMARTPIRGPLVVMISTTVDQATQAQRMIRDLGGPIGIKSALGVGSASATSDLSQELRLLQQNMPHIICGTPQKLHALFTTPGGLSGSEVRFLVLDEVDQLIARNLHDFVFNIIKLLPPPRSRAIGTSPSSVTPGSSAQSSFPIFENGNSSSLVSPFQNPARRFSGVGSSPPIELANSGSSQQIERQTALFSNTVPQDVLNLASAIQLREPVRVLVRRDGNVTHADTSQGARGLRQFYLYLAFTAGGRSDTPLPSGGLGIIGSGRGASSAETAQAREWKLDALADIFDDIEVTQAIIHVGGMTALDAVVYKLASRGLEAVPLHGDMNAGTKLAALNKFRSPTGLMRQPATKVLVVYDVQVKTPEVSQIPLIINYDLPKAVEEYAHRVAPAIAPSYSRAGVIINFVTATGGDVEMLRSIECFYKIKCPEVPLSLRDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAU1</accession>
    <name>A0A401GAU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0204590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610174.1">
        <property type="nucleotide sequence ID" value="XM_027754373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAU1"/>
    <dbReference type="STRING" id="139825.A0A401GAU1"/>
    <dbReference type="GeneID" id="38776178"/>
    <dbReference type="InParanoid" id="A0A401GAU1"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="679"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="790"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="980" mass="107468" checksum="892DDFDB774F3C65" modified="2019-05-08" version="1">MTEAVAPSDPNDNPPMTHQSKKKRVEDQPLSPDIGLKPVQLQRRRVWRACESCRRKKIKCDGNEPTCSQCAASKSQCTWLQTKDRAALSRHYVQELEARLLHMESLFHQVAPILEQVGEASGLDLSCLPPSIAPSQSGAPTIPLNVLQSVLPKVKEVAQNSAAADGSAADTPIKVEDDVSESFGQLALDEHGHMHWIGGSSTMSLIQSFRAMTSSPLHRVSPMEEDPLAPGPSVNKLYFPASVFFGKVHALPRPEEVEYPDRDLADKLVDAYFAKFHFLMPVIDKPSFVLKYKYLMEHTNDPLLARTQTAFIALVCAVFAVAARFVDDPRLSKFENLDAAGMGMVYYERALILHYISHASTQIEHVQCFLLLSSFLCSVNCLPQAWLLVGQAVRAAQDIGLHRSPRRLLIKPIEKETRRKIWWGVYTLDRMLALALGRPLAIEDADCDVELPVDIDDDHLPDYFAGAQMSRLSPSLMKGFIELTLLYRIGGQVLRQVYALDKCRDHLEPEKRAELSRAVDTLDKRLIKWCDDLPAAFKSRPVNEREVSMGAVLCSHYYSILTTLHRNFLPLKRDQPVSPRSTAKAVSTARACIRLAPSIKSVVPPSHHLAFFIQNLFSSAVIILLYAMHSVDPAASTAAMDEVANCLSVLGSWEGHWPGARKCKELLEDLAATAREAIKTSASGQSRGAGSGSSSSASPSSVMSDGWPPGQIPLPVPERLMKHRRRRNSSRDVRDLRLSSPHQSSSAMQFRSDSQRARSTSRKRPHDDDGLDGSAYVLPSSYPGRSSFFSAHSSPASVNSQPSPSGATVDFPQDPSPRIVASNSYGSLNPTSPSVATPSQPRFDYDFTQDRWGVQAGEANGLKFFPSGAGAGAQNTYPAFAPPPPQSPADPAFGYTYDANGADPAMGVFGLSGTPPSSGFAAPGLPFRGLDYIRNFNPGYSNGEQDQLWHTFDPGAFGYDPEIPFTLGDIPAEGRWPDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAU2</accession>
    <name>A0A401GAU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Meiotically up-regulated gene 157 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610201.1">
        <property type="nucleotide sequence ID" value="XM_027754400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAU2"/>
    <dbReference type="STRING" id="139825.A0A401GAU2"/>
    <dbReference type="GeneID" id="38776205"/>
    <dbReference type="InParanoid" id="A0A401GAU2"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF1">
        <property type="entry name" value="DUF1237 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019373932" evidence="1">
        <location>
            <begin position="23"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="504" mass="55797" checksum="905840ACE3A7D231" modified="2019-05-08" version="1">MKLGLAYSVGTAVLLGSAVSYAQCPDYTTYAETPQGNLSIGPLALPYMRPVPACRTFNSSAVEDVISNMTARLRDPDLARLFENSFPNTLDTTVKYFNATENLAFIITGDITAQWLRDTGNQFAQYHSLLSMDQELATLVKAVINNEARYVSQYPYCGAFQPPSESGLSPTVNGYAIDVLVNPPVDNQTVFECKYELDSLCSFMKLSRSYYQATNDSSFINDEWNLAISQILRVIYEQSQATFDDNFDLVSYYNWTGTAGSLSPAVNNGGNGEPKAYTGLVGTSHRPSDDLSTFAYLTPANAMLTVELNYLADILDSVGQASNVSQLARYYSSVISDAIWNTTLVNNIFAYETNGFGGRYVMDDANVPSLLSLPYLGFLDMNHPAYIATRQVLLSRANPYYVVGQNFSGIGGPHEDAWNPWPMALVSSIYGTDNDEEIIQNLYLITNNTAGLGLIHESIDIYDSTYTRPWFAWANSYFSEMMLDLASRKPHLIFTDGQPYIPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB12</accession>
    <name>A0A401GB12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0205560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610271.1">
        <property type="nucleotide sequence ID" value="XM_027754470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB12"/>
    <dbReference type="GeneID" id="38776275"/>
    <dbReference type="InParanoid" id="A0A401GB12"/>
    <dbReference type="OrthoDB" id="16434at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="123" mass="13693" checksum="79C0A26DD1367B35" modified="2019-05-08" version="1">MASSVGSALRKLLPAKLPPSLSSQPGNLYEVLSRYPQDGVGQRVYQTRWSAKGIEGCYWEVTRTKLKLEGTHGKAWGVLVWRGQRVSERDEQIRGGLKYRWAEGMSQARKFTTSPVSPPSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB16</accession>
    <name>A0A401GB16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0205390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610254.1">
        <property type="nucleotide sequence ID" value="XM_027754453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB16"/>
    <dbReference type="FunCoup" id="A0A401GB16">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB16"/>
    <dbReference type="GeneID" id="38776258"/>
    <dbReference type="InParanoid" id="A0A401GB16"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE79341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="216" mass="23461" checksum="79CBF15E28AB85C4" modified="2019-05-08" version="1">MAGTTEKLHILVHPLINSRLSQLRLTTTNAKEFREGIRDISLILGIEASRYLEEETITGQTPVGPFTGSVIKPKIGLTPVLRAGLGMTDALLDLFPAAPVYHLGIFREKVTLQPVEYYSKLPSNPTVDMVFLLDPLIATGGTACAALNMILDWGIPVKQIKLLCILASQDGLNRVCAEFPGIEIWVSAVDPNLTARGLINPGLGDTGDRLYNTLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB36</accession>
    <name>A0A401GB36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610303.1">
        <property type="nucleotide sequence ID" value="XM_027754502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB36"/>
    <dbReference type="STRING" id="139825.A0A401GB36"/>
    <dbReference type="GeneID" id="38776307"/>
    <dbReference type="InParanoid" id="A0A401GB36"/>
    <dbReference type="OrthoDB" id="3248421at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="651" mass="72791" checksum="6D63503B48A5C77E" modified="2019-05-08" version="1">MAYVSVPFPGGASPMMPVQSFPPVVGSPSPTVSQSQIQPGAITYTTTTGPDGQVTYHPFRAIAASYQTSQGVVSGIQWVPAEATQVLPVGATPATSDIMASFNRQADKEWQREEERRRRKEAERRDREHHRTYSRDDDKDLRRARDKDRERERQRERRLSNTYGSGYSPYEPDRKHSATADLERRFQDLDVDRREREYERERRPSTGFGGGTRSRRNSTYGDRPAGYQPAPGGPYPTPAGAYPPSSTAYASPQSTYSNPYTSPQAPYQKPSPYATPSPRPGEVIPPRPVSPYQVGGIQRPVSPYQQGGLGRPVSPYQNPGGVQRPVSPYHNPRPVSPYQMGAIQRAASPRPLPGAYPTTGEGQGIRPSISRVPSPSPYPPPPAMYANSAAAQYGAQYGQGAPQYTANVGYAQGYPAGIAADQQQAILAAPEGFSRPPNLAQPYTHFEIMKIQDMDDFLEVIPRMPLVLVPHDVYHEDWIRLMNDLSLAWSGRLPVPEYARDGRPPKRTNLTTDLIDLWNVSFFLARGVELVLYKGRERRSGRSIGTVDLHLPGFDTYESVSSDDSEDSDDSDDSQDDRYGYGAYAGVYGRQVEGQMAEVREARRVRREKKAEHRKRKIEKKRRQKMKEMERKYSLYLTCTSPREGGLVPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB37</accession>
    <name>A0A401GB37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1742-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0205590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610274.1">
        <property type="nucleotide sequence ID" value="XM_027754473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB37"/>
    <dbReference type="FunCoup" id="A0A401GB37">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GB37"/>
    <dbReference type="GeneID" id="38776278"/>
    <dbReference type="InParanoid" id="A0A401GB37"/>
    <dbReference type="OrthoDB" id="2158714at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013640">
        <property type="entry name" value="Vfa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28218:SF1">
        <property type="entry name" value="VPS4-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08432">
        <property type="entry name" value="Vfa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="191" mass="21227" checksum="A2FBB2030FE26139" modified="2019-05-08" version="1">MSFSNIYYKRAVGTARACYVCHKPTTTVLATIHTVDFIYTCDNHLTDHAFATRVGDPTGAAAKLGVGADEIAKVKKEWEEHQKVKLEKAKEKEKEKEKSKDKEKEADAEKGKKDVKESKDVNNKPAIVPGSLPPDGMVSPPPTPSHERYTLHRDVFAMRQAEQRRRRQAAQAKELAPRLPGAPRSSLPPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCG3</accession>
    <name>A0A401GCG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0210510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610763.1">
        <property type="nucleotide sequence ID" value="XM_027754962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GCG3"/>
    <dbReference type="GeneID" id="38776767"/>
    <dbReference type="InParanoid" id="A0A401GCG3"/>
    <dbReference type="OrthoDB" id="2799448at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="186" mass="20096" checksum="4C0DDA797114F4CD" modified="2019-05-08" version="1">MPGLVQRYNVSVEYSELLSTTPKDPSVRGPSHLSGGRRWRSAAQAAIATEASSWYEAACPSSQDLQVVLRRFHDDPDISRERVFGFLCPLFVFGTLFTVCVVALQPRSFAHHILTAPREHLQELMKFGAALFGGLTAGILFLRTAVWCVAEASTAVVAQAGSGVGRTVRNSETLPSSNVLLGAMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GCU3</accession>
    <name>A0A401GCU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0212080</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 19">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610919.1">
        <property type="nucleotide sequence ID" value="XM_027755118.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GCU3">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GCU3"/>
    <dbReference type="GeneID" id="38776923"/>
    <dbReference type="InParanoid" id="A0A401GCU3"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="16">
        <location>
            <begin position="378"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="270"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1146"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1391"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1151"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1407"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1450"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE80006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1720" mass="191246" checksum="40C9942AFE5AE939" modified="2019-05-08" version="1">MNIAQTVPATVSSISFSFLSADDVRRISVQKIVNPVLLDDLNRPTIGGLYDPALGPSDRSDICATCRLTYFTCPGHFGHIELPAPVFHPLFMTNMYHLLRGVCLFCHRFKVDRSVLCLYVAKLRLLEHGLLVAAETLNDFYVQTEKKDKKSKQGEPDDEDAEFHESYEAFEQRVNTYVALQFAAASTSKRDAYKDGLVYKARKALISDFLKVVTQKRCRNPKCGAHAYTFRKEGYTKVIEYDLSGKQKQAHEAMGLKRPNVLFDQKVRAAPNENSNANDGADDSSQDSESEDDGEDVFSEHNEDEAESAAAAKNLPKSASGKVKGKRGRNERVMPPEECRAHLRRLFANESVVCSLLFGRHGPFAPLGKHNLSYASADMFFLDVVPVSPTRFRPPAKMGEMLFEHPQNELLSRIINTSYRLRDLNDSVRAASLKGSEVDDDTRRRLLQSLLDALIQLQIDVNSFIDSSKNPAPMRQGRLPPAGVKQGLEKKEGLFRKHMMGKRVNYAARSVISPDVNIEPNEIGIPPVFARKLTFPEPVTPFNFHELRQLVINGTRNYPGASMVEFEDGHLQYLDKLSVEQRTAIANQLLTLQEGDHGSARSGLYTRTTAINKKVYRHLRDGDILILNRQPTLHKPSMMAHKARVLQGEKTIRMHYANCNSYNADFDGDEMNIHFPQNQVARSEAMYIANTDNQYLVPTSGKPLRGLIQDHVVAGVWMTAQDSFFTREEYFQLLYGALRPEDDSGHHSGRLVTLPPTIWKPKALWTGKQIISTVMKNITPSNFEGLNLHSQAKVPGYLWGKDTQEDKVIFMDGELLSGVLDKSAFGATDFGLVHSVYELYGSDIAGKLLGILSRLFTKFLQHRAFTCRIDDLALTPEGNAKRTALLQKGAGLGTEGAIDNFPSLSTVDEDEKLMVLRSLLEDVSRDDSKMAGLDMTVKGKLAKLTKSIADACMPNGLLRRFPHNHMQAMTLSGAKGSAVNAQQISCALGQQELEGRRVPVMVSGKTLPSFKPFETKAIAGGYVASRFLTGVKPQEFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGIRVHYDNTVRGSDSSIYQFHYGGDGLDVTKQKHLLQFEFIARNEISFVNRYKPRALHGVVSEEAVEYMKTILKQKKKSPDESYQPTLSRFNPSRHIGSTSEKFAEKVEEYIKKNPHGLLRKKGQDDAPIQRRKHPVSSKHFRLLMNVKYMRSLVEPGEAVGLLASQGVGEPSTQMTLNTFHFAGHGAANVTLGIPRLREIVMSASTKPKTPSMTMLVRPGVPESDVDEFCKKASRLALSHVVDKAIVKERLMGEGNARSKEFMIELLFYPKAQYQAVYDVETAEVMEAFGTRFPMILRKELQVEMKKLDADLKGQISGLGKGKMVRERPGNAGGVDAEAEGDNEAEDSAKGKKDDDENSEVGDGDASAAKRLRQTKEQATYEDDDEDEEPVLGEFDNEEIEAAYAREASGEEDGDNDPESTTEKPQTVEELFMHNFPNATSFQFNEKGCTIGLSFSATMPKLLLVGIVEKTCVKTVIREIPGITDCFKSKEDGKNGETLYKLTTNGSNLSGLWQFACSDVESMIDEDGIYSNDIHAIMYAYGVEAARATILREIAGVFAVYKIDVDVRHLELIADYMTFDGGYKPFNRKGISTNPSPLLKASYETTAAFLSDATLHGDFDDLTTPSGNIVIGRLNSSGTGVFDVVTPVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDC7</accession>
    <name>A0A401GDC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0213800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611085.1">
        <property type="nucleotide sequence ID" value="XM_027755284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDC7"/>
    <dbReference type="GeneID" id="38777089"/>
    <dbReference type="InParanoid" id="A0A401GDC7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="54" mass="6004" checksum="487D41AF33E01B5D" modified="2019-05-08" version="1">MPTQPFSSSMFEYLVQAGQQQRESSLRVTYSFMAILEEVANATVLVLGWAGEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDJ3</accession>
    <name>A0A401GDJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0214470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611150.1">
        <property type="nucleotide sequence ID" value="XM_027755349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDJ3"/>
    <dbReference type="GeneID" id="38777154"/>
    <dbReference type="InParanoid" id="A0A401GDJ3"/>
    <dbReference type="OrthoDB" id="3269308at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18147" checksum="E30859343048E38D" modified="2019-05-08" version="1">MLHRSLDLYPLLIVDNKPATVWLVGEVDSSWFKLRGEPLAVVSIKIGSNTSDVLKASRFQSTGSGEYASVEAFQNVFDADTKFGPRNTMRQMHATDIHKNDLVLVKCNVTRWRVDAKGKASYEKGWTKWRTGFELVTIARLYDGPQEIRAVVPRAEVSSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDM1</accession>
    <name>A0A401GDM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0214950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611189.1">
        <property type="nucleotide sequence ID" value="XM_027755388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDM1"/>
    <dbReference type="STRING" id="139825.A0A401GDM1"/>
    <dbReference type="GeneID" id="38777193"/>
    <dbReference type="InParanoid" id="A0A401GDM1"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="222"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="356" mass="38777" checksum="9F53C9E55EFB8856" modified="2019-05-08" version="1">MPELLSNKRKRPSDEVDELITARNSHSFGDQTEDKSLERPLAKRRLRIVTDVASLTHLTASPSSADLSLDSETDSLFDADSLFDDTSSPRSACLDQTTATSELTSQSATPAENLVPARRTAPLIPGLFFDEALLLPEDLAEDVMWTCIRTYFQSSSADQVMLFERAPSPSPEHDSPPRPGSSGLPPVLTDLLVTLSALLRPLLPPTTHALLFPPPSAAAPRLARQAILNLYWPGEGITPHVDLLDRYGDGVIGVSLGSGCVMQFERVRNGEEDGGEGRERWGVYLPPRSVFVLSEEARYAWTHGIEKRMDDLVEHTPGGAGAGSSWIERDVRLSITFRWLLPGADVVGGPDASEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEE6</accession>
    <name>A0A401GEE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0302100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611408.1">
        <property type="nucleotide sequence ID" value="XM_027755607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEE6"/>
    <dbReference type="STRING" id="139825.A0A401GEE6"/>
    <dbReference type="GeneID" id="38777412"/>
    <dbReference type="InParanoid" id="A0A401GEE6"/>
    <dbReference type="OrthoDB" id="3218226at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="161" mass="18831" checksum="1112CBA6A97410D0" modified="2019-05-08" version="1">MHELARQQMADRVRQGSPKFTLGQKVWLDLRNLKVNYASRKIAPKREGPFEIVEVIGSANYRLRLPKTWQVHSVFHAALLSPYHENNIHGPNYVNPPPDVMDNEEEYEVKAILNHKAYRGHLRYLVKWKGYSSAENSWEPAHNLQNAKQTLDVYKRMRGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF14</accession>
    <name>A0A401GF14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere replication protein EST3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0304120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611606.1">
        <property type="nucleotide sequence ID" value="XM_027755805.1"/>
    </dbReference>
    <dbReference type="GeneID" id="38777610"/>
    <dbReference type="InParanoid" id="A0A401GF14"/>
    <dbReference type="OrthoDB" id="3144405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="949"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1296" mass="139793" checksum="C1FD29E0BA81F41E" modified="2019-05-08" version="1">MADSIHSAWISDYLIQMAEAYGGDLGAIPPREKPGRAQLFLTYLRPEDEGSCIWALLSDKAHIIHVRLTSEAIKQHKLNPTFHGKSLTQYKTALVLIKNFRPCFARVPLGGGDGRGMSPSEQLFLEIAHFQVKGSFDEDVWGSPNDIAANAKVSEWMEGLRSGGGGGLELQALQARQQVSEVFAEKQPVGQQTLPRRPAQIAGARKTVKRAPQAVPATRPAPASAEVRVDPKKVYEKSWRYVTSSSARRKRALPPADLLAVIHKVTLVSNGEVEAVRDPHTDAKAVTSMAESSTPPKPPRPRRNPLDISSSPPGSPKAQSPEPLPATPSHWSESSPGSPQPDLPDAETSDSEDEANQFTDHNGSPRARNLMASTEKTLVGDDDDAQSDLKKAKVPYAPLPNTLSSYLSAPTPAQRPMPLSSSPLPNPPSTPTASKDPQMSSAKTPDTRTPLQRPYTRRVPLPRAGRSVVSIGRILVPNSDTSGTASQPQSQEQGQLQSQSQLSQIIPEPSQPSQSQSQPSQTSQVIPGPSQIQHGSHRSPSRAPPSQNHSQSQSQNHESGQSACTHQSLSYTSQSSYEKGMSQGQMQTSRPTTRSQLRNEVEILPSSDAPIAPKSVTETAHQATLAEALDRSPELKTGRAARRSSKGVFTAKEAHGTEPGGRAALRSQATKPTDGNDISVTEDEDADDEMDVDELDMSRSPRGTHPLAREEEESLPVEEEEESPSIHSLPVTEEDEADEVEGKSRPQRSRAHPLAQEDEESQTAPVQAVAEESQTHAQEGAEGGRASSNELDSGDAWTKVVVDGHSPERAENTASSEKKRSSRVRSPGSRDVSPKPAKARRPLKRQATHSSLHDEGSDAPLRPSSPDVFLSEASFHASQDIPPMKLTSRGSFSKPHPAQAPRASTSNSVVAQPTLSSAVKTPPSGKPHAPAETIYHYPEAWRAPAFQLLRTNGKGKEREQPIPKAALRQPAARSKRPIEVVSSPEHPPPKKQKLSVTSFAPASATSMSGPSVGDEKYHVFLKNQNLTSTTSADESFHRDQRQDSSSKIQLVPSAGSSSRQIERQNMPSEVQATAGSATNGTGRHTNGLSVKKLDLLRTASMSSSAPSTKRKRPNDAERSMKASTSKPEVRTIQQLSPGGSTSHEIKQVDFSSTESSRSLSRKRDKRAGSGAVQYASFKQDIRPLVQAAKDVSARQVAENSRASSSRAVGSTCVKMEQDDSQPDDSGEPASGGEVPATRSSSGLLGGYFVDFNMVRARDGPPLVTWRELSNILLRTGRTRTLAQRRMLGEHPRPKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFX4</accession>
    <name>A0A401GFX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0307260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611916.1">
        <property type="nucleotide sequence ID" value="XM_027756115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFX4"/>
    <dbReference type="GeneID" id="38777920"/>
    <dbReference type="InParanoid" id="A0A401GFX4"/>
    <dbReference type="OrthoDB" id="3145912at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="32938" checksum="FB6B10678A6792C9" modified="2019-05-08" version="1">MHSSRLVFADLPTELLRDIFEHAADLDRPTALSLVLVSSPVRRWTEPALYNTVVLSTAPALRAFLAAISHKSPEFVHARVKHLGVFALGPIQSIHRVLHACTGLRTLACGFSLPGYQRTQGARPLHARLSREQHFLGLSCRDGWDTALVGPSVTHLRIHLTAPDSCSPDAPLGLARAAAHEDASTWERFARLAALTHLAVVHAVSPSTPATALLPMLHRLLAPPSSPAGAAGPPNLQLVLVQVIGGACDASAAHASTAALNAAAIAAGGPALRIVAECAPLSVVRQWEDAARGGPGVWEAAEGVVRARLAAARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH16</accession>
    <name>A0A401GH16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="10">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0312060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612390.1">
        <property type="nucleotide sequence ID" value="XM_027756589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH16"/>
    <dbReference type="FunCoup" id="A0A401GH16">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GH16"/>
    <dbReference type="GeneID" id="38778394"/>
    <dbReference type="InParanoid" id="A0A401GH16"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="508"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE81477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="585" mass="62830" checksum="97C748B8D8F7C154" modified="2019-05-08" version="1">MAQVIVVGGGLAGLSAAHTLLERGANVLLLDKQGFMGGNSTKATSGINGAGTRSQQELGILDNAKIFFDDTKDSARELARDDLIRVLTGRSGDAVNWLQDKFGLDLSKVARLGGHSQPRTHRGSAQFPGMVMTYAQMERLEDLSVSTPDRVKIKKKARVTKLVKDDSGAVIGVEYEHNKKTETAYGPVILATGGYAADFTSNSLLRKYRPEFFDLPTTNGDHCTGDGQKMAMAIGAHAIDLEKVQVHPTGLVDPKDPEAKVKFLAAEALRGVGGLLLDNQGQRFVDELQHRDYVTGKMWENGKFPIRLVLNGQASADIEWHCKHYVGRGLMRRFESGEELAKEMGLKPEVLKKTFDEYNKVVRSKKDPFGKKFFASGEWSMNDIFNVAIMTPVLHYTMGGLEIDSESRVVDTNEKPIPGLFAAGEVAGGVHGANRLGGSSLLGCVVFGRVSGDSAASYLLQVLGPLAGKAAGRLGAVAGHLGAPSSSNAAEPAAQKAPEAEGTHSAGGKAFSATEVAKHNKKDDVWVIIDNQVLDVTNFLSDHPGGEKAILLYAGRDATEEFNMLHDPKVIPRYAPDAVIGTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHA5</accession>
    <name>A0A401GHA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_0313050</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612489.1">
        <property type="nucleotide sequence ID" value="XM_027756688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHA5"/>
    <dbReference type="FunCoup" id="A0A401GHA5">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHA5"/>
    <dbReference type="GeneID" id="38778493"/>
    <dbReference type="InParanoid" id="A0A401GHA5"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="105"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE81576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="445" mass="48911" checksum="CD7D1591611BA5A7" modified="2019-05-08" version="1">MPRRIGDIDGDSDSDVSIFDDAEGVTRGKGKGKGKAIDRRKKNKGKGKAKEQPYAWEASYTRSWDTVQEDEAGSLQGAVEDLIARGRRRRLLAPAAAIRRSIIRHLVLLLDLSSAMMDRDMRPTRFDLMLQYTRDFINEWFDQNPLGQIGIVGMRGGIGERIEEMSGNPQEILKAISERHKLEPAGEPSLQNAIEMARSSMSHLPTHSSREILVIFGSLTTCDPGNIHDTLDECVKDRIRISIVALAAEMKICRDLCEKTGGQFGVALNEGHFKDLLFELIPPPAQRAMTRTASGTPSNPAADLMMMGFPTRLPDTSPPTLCVCHSQLKSEGFLCPRCLAKVCDVPTDCDICGLMIVSSPHLARSYHHLFPVKPYQAIMSLEDSMDITSTCHGCGLTFQTAGSGGVTEGMSPLGRYRCPECHNDFCADCDVFVHDVVHCCPGCGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHF0</accession>
    <name>A0A401GHF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FAM72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0312740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612458.1">
        <property type="nucleotide sequence ID" value="XM_027756657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHF0"/>
    <dbReference type="STRING" id="139825.A0A401GHF0"/>
    <dbReference type="GeneID" id="38778462"/>
    <dbReference type="InParanoid" id="A0A401GHF0"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="46636" checksum="ADC3C639BD1D01F8" modified="2019-05-08" version="1">MPGRTYPDRVLNITHFHPPHAPPHVDMLPDDHSATSPRVSQDFPAVYPAPSIPPPLHIHHYNLPSYRANYILIPPGHLHLYPGLHPTLSSPPWPHRARVQSVVPVPPPPPPPILHKVRILDCMSCGTFFTNRGMKAVLLLRPNVPLYSTDALPINCSADSAAQDTPSAGSSTSTLLPSSQSIAAEHVPSRSCECLTQTLCCHGCGSSVGYMIVIPCQRCTSSITASNRATNGHRFVFYSSEVTAGERRYITGERGVLVHGVPRSYYRPPQVFLPPRHSLVMVPPLYTPRSSHTDYLPTPPPEVEHSFRSDASPDTSDVPAPISPSPPSDPFPADADTRPPHSTPHSPLVSPPASAPPPPAPQPQALRAGDVLFWHHLARSGEIPAVVDDARARGVPGSDAHTKWEDDARVGGELYVETGPRRTTKGLVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHX4</accession>
    <name>A0A401GHX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0401770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612717.1">
        <property type="nucleotide sequence ID" value="XM_027756916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHX4"/>
    <dbReference type="GeneID" id="38778721"/>
    <dbReference type="InParanoid" id="A0A401GHX4"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="504" mass="54269" checksum="CBCF3B976F25B9A4" modified="2019-05-08" version="1">MDIAALSNMYKGGFSLLLIQPRPAHLSLSPRQLFAMSTQYTLSDMPHLASTSSVTPHMDGFLHWTYDGKRFLFFLSPDCVYEIPCETSCGVPCDSLDVACGPSYDTASNISNTPFNASSDTSFDTSSDASSDTDSDSNSSLNNDSEMVEPETVVHASCPIVSVRPRVPIKGFAVRTRPGSFVAQAGVSPAKFAAQPQIPLGSFACPPGGLAAQSSYPVSSSVSLGYSDAGVGIQTDFSRFAGSSGVSLGCSAVDASIYSSQPVAQPTAFDMLQSEQMVQDVFQQFQEELSNTMQQMPVDMLQSIQPQAPVDLNSMQQVQTETSTGIGSCYQDTSVDVCLLAACILEELRSTTPGTALFHNLLSSFPPDLQLALSNSTLDPSVFEQLVQFLERKSTDFTVPQASFISGPMFHCVRCHQNYQMSENRPTECRLYVHQGLTAVPIWGSWMLCRSDGLLLDPATDSVELRFKGWHTPYVQHLPPACGAMSCARLQCPSAFGVNTGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHZ7</accession>
    <name>A0A401GHZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="4">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0401890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612729.1">
        <property type="nucleotide sequence ID" value="XM_027756928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHZ7"/>
    <dbReference type="FunCoup" id="A0A401GHZ7">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GHZ7"/>
    <dbReference type="GeneID" id="38778733"/>
    <dbReference type="InParanoid" id="A0A401GHZ7"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE81816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="794" mass="87561" checksum="C660BE98C3811DC5" modified="2019-05-08" version="1">MLADPSKKYKPYTPLNLTDRQWPSKVVKKPPIWLSTDLRDGNQALANPMTIPQKTLFFHTLLKCGFKEIEVAYPAASDTDFNFVRGLIEEGQVPDDVWLQVLTPAREDLIKRTVEAVAGVKRAIIHMYNATSCTFREVVFRNSKEETVALAVKHAKIVRQLTEECTAKHGTLFRFEYSPEMFTQTEPEFALEICEAVKAAWGRAGTAPMDRIIFNLPATVEIAPPNHYADQIENFCRNISEREKIIVSLHPHNDRGQGIAAAELGLLAGADRIEGCLFGNGERTGNVDLVNLALNQYTQGINPGVDFSDIQAVIDIVTQCNDLPVHPRHPYAGELVFTAFSGSHQDAVKKGFEAQRIRHAKAAATGEPQYWDMPYLPIDPADLGCNYEAVIRVNAQSGKGGIAYLVQQHLQLDMPRKMQISFYQIIQEIADREAREMTVEDITEAFRTTYHYGGSKYEGRLVLKSFRISAEPSADLVTSDEAADERRQFDGTISVDGVLRVIRGDGNGPLSALLDALRTHLEIDYSIREYTEHAVTQSQNAKAASYVELVPSAPDVKGTRRSAESWWGVGVDSDIAGSGLRAVLSAVNAVIGTRELPELRLSVGYSAKSGQADIASVVLNSLHLELPRRLQASFFEVVQRAARESGGEISYSDLIALFRETYGYEVPDREGRFVMNSFHMDNLLESGRKELTGEFVINGELRQVSGQGNGALSAALDALNQHLYGKVGIREYSEHSIGEGTEVKAASYVELAYEADGGAVRFNAWGVATDTDIAASGLKALLCAAGRIDLMTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GI76</accession>
    <name>A0A401GI76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoinositide 3-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0401780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612718.1">
        <property type="nucleotide sequence ID" value="XM_027756917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GI76"/>
    <dbReference type="FunCoup" id="A0A401GI76">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GI76"/>
    <dbReference type="GeneID" id="38778722"/>
    <dbReference type="InParanoid" id="A0A401GI76"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="5">
        <location>
            <begin position="122"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="776"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="894"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="825"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="865"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="262"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="367"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE81805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="922" mass="101181" checksum="FB5EE5F32431D1EF" modified="2019-05-08" version="1">MDAIRVAKVEGVLCSKGGSTLSGTLHLTAHHLIFCYDESEREEMWAPYPLISLVTRLPLTLQGQCPLTVRMRTFESISFIFVSERDAIDVFESVKELTVATSVNQLYAFFYVPNPPLPVQTGWSLYSPREEFGRMGVGSRTKAWRFTDINKDYSFSPTYPARLVVPTRISDTTLQYAVKYRSKGRLPVLTYLHWANYGSITRSSQPMVGLKNNRSIQDEKLIEAIFQSHHSPESRAANMPIYGATATNLIIDARPTTNAMANTAKGAGTENMDHYKDAKKAYLGIDHIHMMRESLGKVVEALREADSLLSSLGASDQSTGEGIVASVLDRQALRRSGWLKHISAIMEGSLLIVRNVHVNSSHVLIHCSDGWDRTAQLSSLSQLCLDPFYRTVRGFQILVEKDWLSFGHKFLDRCGHLSSEKFFLAPVESGGGGGGAEAAQAFLASVQNRFASPNHIKETSPVFHQFLESVRQVQRQFPERFEFNERFLRQLHYHLYSCQFGTFLFNTERDRRVGEGSIAPACDRTVSVWDFFNSPPEAALNLNPDYDPSLDDPTSRAPKADMGVLMPNPKDVRFWHELYGRTDEEMNGKFRQLAQETDIAGPVETVDDETPVIQAVSPPCISLPPSPVTSPPPATPTQQSLARKVFERSQSPALVASSSTSEPLRPRHESLRGMDAQLSPTRRTHELTVPSRTPSPGVADLSASPRAGVSAGQVTDLFSSSNVRSMWGRFSSNASAAFSVVQDAYGGVAKDLRGLSLGGDTGGDELKTREEIGVWGEQEQHERRPSSARGPGKVYTATATNPWSTAKARPNMPSMFLDNPWSSHTPDRESETHSAPELDMPTPTSALPADPTVALPSWTPVRKSSINTLPRSSSRGSTHSTPLISLGADLPLVTHPLPAASVGSTPPAVSPPSSDPLGVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GII6</accession>
    <name>A0A401GII6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0403440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612881.1">
        <property type="nucleotide sequence ID" value="XM_027757080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GII6"/>
    <dbReference type="STRING" id="139825.A0A401GII6"/>
    <dbReference type="GeneID" id="38778885"/>
    <dbReference type="InParanoid" id="A0A401GII6"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="260"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="524" mass="59467" checksum="343D6EB22D69731D" modified="2019-05-08" version="1">MPRGRVRKVARTPQKLTQHTLDGFVGSSSPLGPRRAATTPSKPRKAAQKQARVTISRDSSISDARASGSESTDVAAIHFEPEDQDSDEDRQPRPSMSTKKKVRHARSGSEEMEEVEDVASSQDEETVESPVAWKGKRKGTKRKQVLDDSEEEEVHPKMRKLVRGIRPPSPDEEEADILDEVDEERILESRFRTRNKKSTFQRNLERLKRKKRGESNRSECSSSASGNEEEEEHVAPFAFAQPETLHPSHDDSGHASDDDNFILEDDTTTALELPAEFSMDTHQDLTHQFKIICQLFVHVAVHKARDRRAAMKQLLENAYFSVPLQIARRKITGMRDSLVTSSVWRLEFKKPLEAYPEFATVRLDFAIPTCDACHLGGRMSTLLGRLSGMPYDKLSFEPLPVNISSDSDSSEDEEDNTKKEFHLGRFCAARTHVFHKFTHWEYATFKALLQEVDELRGNDRSDGFVRVAYAGGVKPPEDLSDADGIMDWLDERGVINMEWQRIKEMMEGARQLDMRAKKGEEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIU9</accession>
    <name>A0A401GIU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0404570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612991.1">
        <property type="nucleotide sequence ID" value="XM_027757190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIU9"/>
    <dbReference type="STRING" id="139825.A0A401GIU9"/>
    <dbReference type="GeneID" id="38778995"/>
    <dbReference type="InParanoid" id="A0A401GIU9"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE82078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45111" checksum="E48BE2EED1FC47BA" modified="2019-05-08" version="1">MSLRRLAQHNVTGVPVTPRTSSSASSSGAASPVPSTPVRPPSTPRTRLVYPISPVSSPSLSASVAFDWDAVRLRRTPPYATPQRVKALRKSDVGTPGSTKATPSKRVVRKKGFVERITSLPSRIAFEIALFPHNVPLPAPKTSAYLLGGFAHFMHLCICVSQIRRVPDSDLGWEDMYREGEGDSWFDWTVPTTALLFAVAILNTMYLFTRTRLYQLNLATEPVSSPHATFVERPRVVRAHDDDDDDFGPAKPTSARFMSFFSSAFWSLWRAFVISVRFLLNFSPSTDRTPARRRRAERLQQLEVWAPGELENVLFAIYSPVHALLWTAVSSANWMRMLIVMAVVSAQLRAVTYSYEALLKDRTIIAAEVLHEYDEKFVFPRVNPVRKDAAVMTHQAEMVDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJG3</accession>
    <name>A0A401GJG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized J domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0406900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613219.1">
        <property type="nucleotide sequence ID" value="XM_027757418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJG3"/>
    <dbReference type="FunCoup" id="A0A401GJG3">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJG3"/>
    <dbReference type="GeneID" id="38779223"/>
    <dbReference type="InParanoid" id="A0A401GJG3"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="354" mass="39861" checksum="DE0E8B18E2393872" modified="2019-05-08" version="1">MDDREDPISQFFPGNNEVDLYDVLSVKSDATSDQVKKAYRRLALTYHPDKHATASDSAKADASLKFQQVGFAYAVLFDEKRRKRYDLTGKTDEGLDLAPGEDGWDAYFEDLFESVTREKLDEHKNEYQGSAEEVEDIRKAYHSCKGAIGEIMKHIPHSTHDDEARFVLVISDLIRNGELSSLPKWESSSKDEKARLVRKKQSDKEAKEAEELAKELGLWEDFYGSGKPSSKKGKRKGKGKQQDEDEDGGEDHSALQALILKRKKNVDGFLDSLAAKYAEPERGANAKKGSKRRDGPVDDEESPKKKTKKSFDPPDIDDEEFEKLQQKLFADRPKGGSAPGEKGRKAKAEGWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJM3</accession>
    <name>A0A401GJM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0407520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613281.1">
        <property type="nucleotide sequence ID" value="XM_027757480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJM3"/>
    <dbReference type="GeneID" id="38779285"/>
    <dbReference type="InParanoid" id="A0A401GJM3"/>
    <dbReference type="OrthoDB" id="17066at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="230" mass="26251" checksum="15F5CEC65DC827D1" modified="2019-05-08" version="1">MSRLASFKGPSTPTSSPVQARQPVTPISPSRLSESTYHRKLRSLLQELRAVTETWDDIVLVDGLKAAKTLVDARTELDNDLAVLPAGTRPAYRIVQPKLELMEGRIADLDAVIVKLKKQFAKMNNLVDSIEAILFEAHKVKGWEWVQDPLWVTWSLEKFVSSVPEILIPYHRSLEMHIELVDTLRSHDVTFEASRYAIAQWVVQPHLEEGSWDAQWEDLCAAEIDRWNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLF3</accession>
    <name>A0A401GLF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE82982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613895.1">
        <property type="nucleotide sequence ID" value="XM_027758094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLF3"/>
    <dbReference type="STRING" id="139825.A0A401GLF3"/>
    <dbReference type="GeneID" id="38779899"/>
    <dbReference type="InParanoid" id="A0A401GLF3"/>
    <dbReference type="OrthoDB" id="3208495at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="196" mass="21988" checksum="E2A191F3628C4E75" modified="2019-05-08" version="1">MYGTSDMKSISEVDSLIHDVLLADDFDANHLQNFSAARELKRLDKHSQTSDAFDIPTTATHGLSDWQFYYVNMFIDRDMFMKYLGGAVGHKGASVSPTEDNDGMDIDDDESDDDNQSVDSRVQDEDEDEDEDEHEDEDEGPIAQEEDDYGYDISDDEEDEEGAGDEGIDHEEEDLGPEDGEDGEEDEYGDEGYAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLN1</accession>
    <name>A0A401GLN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">SCP_0501500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLN1"/>
    <dbReference type="FunCoup" id="A0A401GLN1">
        <property type="interactions" value="686"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GLN1"/>
    <dbReference type="InParanoid" id="A0A401GLN1"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="277"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="534"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="771"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1031"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="635"/>
            <end position="637"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="642"/>
            <end position="648"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="734"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE83103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117743" checksum="E6C302321B38016F" modified="2019-05-08" version="1">MRKQLDPRLPILINNNVKKNHRSFVVLVGDKGRDQVVNLHFLLSQARVSARPSVLWCYKKELGFTSHRKKREAKIRREVKRGTREANDQDPFEIFITVTDIRYTYYKESHKILGQTFGMCVLQDFEAITPNLLARTIETVEGGGLVVLLLKTMSSLRQLYTMTMDVHARYRTSAHDTVVARFNERFILSLGSCDDCLVLDDELSVLPISRGKDIVPLEEARGKSKAESELKDLKDSLADTKPVGELVKLAKTLDQAQAILTFVDAIAEKTLSSTVTLTAARGRGKSAALGLAIAAALAHGYSNIFVTSPSPENLKTLFEFVFKGMDVLGYEEHLDYDIAQSTNPDFNKAIVRVNIFRQHRQTIQYIQPQDAHVLGQAELVIIDEAAAIPLPLVRNLIGPYLVFMASTINGYEGTGRSLSLKLIQQLRESTRPSLTKDTAAGEDDAAASSSSKKPIVKAPPKARTLREIKLETPIRYAAGDTVEKWLNSLLCLDATVVPRSSAHSCPHPAQCELFYVSRDTLFSYHPASEVFLQRMMALYVASHYKNQPNDLQLLSDAPAHHLFVLLPPIKDDESTLPEPLVVLQVALEGNISKQAIMDGLNRGFRAGGDMIPWLISQQFQENKFALLSGARVVRIATHPDYANMGYGARALQALNSFYSGEYFNLDEVSKPEPAYPDPATIDESTSLLTDKPTIRAATAMPPLLQRLTERKPETLDYLGVSYGLTPQLLRFWKRAGYIPLYIRQTTSDLTGEHTCVMVRGLNSSVESELEWMGEFAKDFRRRFLSLLSFKFREFGSVTALSILEAAKNGLKKLDADPARELASSEMSFLLSPFDLKRLESYANNMLDYHVIMDLLPTVASLYFEKRVGEGVHLSAVQSSILLALGLQRKTIEEVETELQLPVSQALALFVKVIKKITKRLLDIQKTAISADIPEEPPAVSRIAVDGTQTSWKPVETSLEDELAEAGDEATRALREKQREMIDSLDLSKYAIDDASANWSMAEAQVAKLTGGAAGKSTVVSVKSTVAAGQKRKVEDVPEKGGKSGEKDRKGSRRSIKRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLT7</accession>
    <name>A0A401GLT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0502040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614070.1">
        <property type="nucleotide sequence ID" value="XM_027758269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLT7"/>
    <dbReference type="STRING" id="139825.A0A401GLT7"/>
    <dbReference type="GeneID" id="38780074"/>
    <dbReference type="InParanoid" id="A0A401GLT7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="2">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="37955" checksum="B3C1836C0166EC0C" modified="2019-05-08" version="1">MDEGRHHASQKELGFRKPEIFNGSDRSKLREFINQCKNYMAGNSHVYQEDNQKIAFVLSHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTRTADDYIAEFRSLESKAKLEDAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTTTRGKGRSVHRPYYSASAKDPNAMDVDRVNISRLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETLKEETREEQIAYVRNVFNDMTDEERTQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLU7</accession>
    <name>A0A401GLU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0502280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614094.1">
        <property type="nucleotide sequence ID" value="XM_027758293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLU7"/>
    <dbReference type="GeneID" id="38780098"/>
    <dbReference type="InParanoid" id="A0A401GLU7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="240" mass="26944" checksum="17714012CE065265" modified="2019-05-08" version="1">MSTQTTHVTSGCHHHLTEKENQRMTEREDTICCKADKFKKSDKADCRAHLCQQEADSEEVDKEKLIVSDIDGTEDNMFTKRTVTTKLSAKKSLAYCFEKVPLASVNNKGPKRGDVPMLVSSSDEDNDVVPVIPRCILPRKKVMRALIDDTENATTITPVAMCMAKKHPCDDEDEDNDNDDGLLSPKYQKSTDGPKCPRVKDFDNFMQEVLVITISVFQCKVSSKGPFPDTSTFETEMAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLV0</accession>
    <name>A0A401GLV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0502120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614078.1">
        <property type="nucleotide sequence ID" value="XM_027758277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLV0"/>
    <dbReference type="STRING" id="139825.A0A401GLV0"/>
    <dbReference type="GeneID" id="38780082"/>
    <dbReference type="InParanoid" id="A0A401GLV0"/>
    <dbReference type="OrthoDB" id="3033349at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.20">
        <property type="entry name" value="Centromere DNA-binding protein complex CBF3 subunit, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038279">
        <property type="entry name" value="Ndc10_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031872">
        <property type="entry name" value="NDC10_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16787">
        <property type="entry name" value="NDC10_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ndc10" evidence="2">
        <location>
            <begin position="197"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="1">
        <location>
            <begin position="711"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="90035" checksum="60A30084A8F8FBED" modified="2019-05-08" version="1">MNPLAAVAATGSLRHSLARLELESHDTRVKKVRLDQDNNQTSSSYDCHVKNYMTYWATFQAERCQRALGEVPVSAFPVTALKASFFLEYEMTREKRRQGKNETITGSNVGKSHISQVINALESWRHNNAYLYKDDPDAQMSLCTDICICTAESLAKHQEPKCIEKAQALKAMGSSGDTYTPDELKRCSIWCLMDVSGVKSIWIGLRDRAMLLLSSTMAFRGESSCILKWLDLFLSSIPIDDVRLGYRVPVLAALADNAKHNQQGRLDEHEAICHREVELCPVGALAFLFFGFFHVLHLPLPNLLPDFEDNACGEYGRGDWYGYHVFWGKQPAAAMSYDNHCDRLRGIHEENNISIMKVTHAGRAYAAQTARAHDATVSGTKALGGWNENGSFCQCYERTFPVNALLGAAMFNGCKPEMYSLPRDALEPPSELLAQVFLWIEQKQAALETCIQDNPLAQDYALCHFLRLMLWLHRVLLQDTAILCTMQPSAPVFAFAPFNTPTFHTFASQAMPAIWEAEEQARVAYQNLPEHLIRSLRGATTNVLMEQKRQHEESNRQMSDMSEWILKMEGMIGTLLNSRSTRRSKITFVPPKQSPAAPVTAPASVPAAAALPVITINFNGSDGPVSTSAVPSVSTLVSAIANGAASSDSTAALDGSSRHVAAAPALPSVSGMVAPSVAPTHADPRSARQDELRQKYGEVIFQKHEPWVWKQEWTDGLGGHISVRELTEKWGNCWRLNDAGLKTEGGHRKKIIDLITELLQKPRWSIQLVLRFFNEKYGHYRVRSFADYLTKHGGAGRREVLQVATHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM09</accession>
    <name>A0A401GM09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor spp42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0502590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614125.1">
        <property type="nucleotide sequence ID" value="XM_027758324.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A401GM09">
        <property type="interactions" value="998"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GM09"/>
    <dbReference type="GeneID" id="38780129"/>
    <dbReference type="InParanoid" id="A0A401GM09"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="2135"/>
            <end position="2266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="2367" mass="273636" checksum="D5815C01890AA7C1" modified="2019-05-08" version="1">MSYPPGMPLPPPGMSMSMSLPPGIPPPPPGMPLPAGPSEQNFRMPPEVIAQKSQKWIQMQKKRYGEKRKGGFVDMGKQDLPPEHVRKIIKDHGDMSNRKFRNDKRVHLGALKYVPHAVMKLLENIPYPWEQVREVPVLYHITGAITFVNEIPRVIEPVYHAQWSSMWLAMRREKRDRRHFKRMRFPPFDDEEPPLDYGDNVLDVEPLEAIQLELDEEEDAAISNWFYDPKPLVDTPFVNGASYRYWSLTLPVMANLYRLGRTLLSDHADGNSSYLFDKRSFFTAKALNMAIPGGPKFEPLYRDMDTFDEDWNEFNDINKVIIRQQIRTEYKVAFPHLYNSLPRSVHISPYHSPKNVYIRTDDPDLPAFYFDPLINPISLRGFTPKNAPLESHEDMIFGPNDADDDDFELAQDLEPFLEEKLLENDLTADAIALWWAPDPYSRRSGRMRRAQDIPLVKNWYLEHCPPGQPVKVRVSYQKLLKCYVLNELKTRPERAMTKKNLFRQLKATKFFQTTRLDWVEAGLQVCRQGYNMLNLLIHRKNLNYLHLDYNMNLKPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDAHVQFRLGNVDAFQLADALQYIFAHIGALTGMYRYKYKLMRQVRMTKDLKHLIYYRFNTGPVGKGPGCGFWAPGWRVWLFFMRGIVPLLERWLGNLLARQFEGRNSKGIAKTVTKQRVESHYDLELRAAVMHDILDMMPESIKQNKSKTILQHLSEAWRCWKANIPWKVPGMPTAIENIILRYIKSKADWWCSVAHYNRERIRRGATVDKAVVKKNLGRLTRLYLKAEQERQHGYLKDGPYISAEEAVAIYTATVHWLESRKFSPIPFPPLNYKHDTKLLVLALEKLKEAYSVKGRLNQSQREELALIEQAYDNPHECLSRIKRLLLTQRAFKEAGIEFFDTYDKLIPCYDIEPVEKITDAYLDQFLFFEADKRGLFPAWIKPADTEPPPLLVYKWCQGINNLTDIWETSDGECNVLMETVLSKVYEKIDLTLLNRLLRLILDHNLADYITAKNNTVLTYKDMAHTNAYGMIRGLQFSAFVFQYYGLVLDLLILGLQRASEMAGPPQMPNNFLQYRDSATETRHPIRLYSRYVDRLHILFRFTAEESRDLIQRYLSANPDPTNNNVIGYNNKRCWPRDCRMRLIKHDVNLGRAVFWNVKQSLPRSLTTIEWEETFVSVYSKDNPQLLFSMCGFEVRILPKIRTMSGEQFSLKDAVWNLTNEQSKERTAQAFLRVSDEGVQQFNNRIRQVLMSSGSTTFSKIVNKWNTALIGLMTYYREAVIHTNELLDSLVKAENKIQTRVKIGLNSKMPSRFPPVVFYTPKELGGLGMLSMGHVLIPQSDLRWSKQTDVGVTHFRAGMSHEEDQLIPNLYRYLQPWEAEFLDSARVWSEYSMKRKEANAQNRRLTLEDLEDSWDRGIPRINTLFQKDRHTLAYDRGWRVRTDWKQYQLLKHNPFWWTSQRHDGKLWQLNNYRVDVIAALGGVEGILEHTLFKGTYFPTWEGLFWEKASGFEESMRYKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAHLWQKIHESVVMDLCQVFDQELEPLQIETVQKETIHPRKSYKMNSSCADILLFSAYKWNISRPSLVTDSKDVLDGTTSNKYWIDVQLRWGDFDTHDIERYTRAKFLDYISDSMSIYPSPTGVMIGMDLAYNLWSAYGNWFPGMKPLVQQAMAKIMKANPACHVLRERIRKGLQLYSSEPTEPYLNSQNYSELFSNQIIWFVDDTNVYRVTIHKTFEGNLTTKPINGAIFIFNPRSGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALVRSLPVEEQPKQVIVTRKGMLDPLEVHLLDFPNIVIKGSELQLPFQACMKMEKFGDLILRATQPQMVLFNLYDDWLKSISSYTAFSRLILLLRGLHVNNEKAKIVLRPDKNTITEPHFVWPSLSDEDWIKVEVALKDLILADFGKRNSVNIASLTASEIRDIILGQEIAAPSVQRQQMAELEKSSEAQGQVTAVQTQTTNIHGDAIQTVTTTNYEQQVFSSKSDWRVRAISATHLPLRLQHIYVSNDDVRDDAASFTYVLPKNILRAFVTAADLRTQVAAFLYGVSPPDNKQVKEIRAVAWVPQRGNNNSVELPSQLPRDDFLLKDLEPLGWIKTQALELSHLSPTDVTTQAKLMADHPEWGSSSICLTCAFTPGSVSLSSHSLTVAGFEWGRKNADTSPNPPGFNPNMSERVQLLLSDRILGMTLVPEGRVWNYGIGLTQLWSPTLSYSMTLDTPLLFWAEEHRPAAFLSFANLEAGDDSADVENSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM21</accession>
    <name>A0A401GM21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfite oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0503110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614176.1">
        <property type="nucleotide sequence ID" value="XM_027758375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM21"/>
    <dbReference type="STRING" id="139825.A0A401GM21"/>
    <dbReference type="GeneID" id="38780180"/>
    <dbReference type="InParanoid" id="A0A401GM21"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="132"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="312"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE83263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="420" mass="47444" checksum="C18B7855A8FFDADD" modified="2019-05-08" version="1">MTATEAKFKGIPRSHPFPEEKVGWRGYVEWEDKPDRKAPATQILNTKHFMPPPEFQLVPLPDTNPILIGHRWKEYHEALGLKSIVAQSWATVCIEKPGMIHILDFPYNGEIPREPLLAGKITDNQYHFVRNHRRIPDIDEDAFELEVGGLVRRPVEFVMKELKDPSKFLVNLGEKALCSGTAVYRGISVKNILDRACDGVLPEAKHIKFISADTYFKKNNVYHYAVSIPYRKVKQDQEVLLAWEMNGVALPKIHGFPLRAVVPGVIGARSTKWLYKVNALAEASMGPVQRQEYPYYPSQFGKHNVKCSNGFSIQNMPVSSAIMFLLDKQVIIHEGSIEFRGWAYSGGGGNWVERVDVSPDGGYVWYSVELGDMTEKHYWTWQLWKIRLPVDASSSSCACAHGTLPATQNQPLFAPPGSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GM22</accession>
    <name>A0A401GM22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sas10 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0502460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614112.1">
        <property type="nucleotide sequence ID" value="XM_027758311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GM22"/>
    <dbReference type="FunCoup" id="A0A401GM22">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GM22"/>
    <dbReference type="GeneID" id="38780116"/>
    <dbReference type="InParanoid" id="A0A401GM22"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="5">
        <location>
            <begin position="578"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="438"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="652" mass="73039" checksum="D27FB5A7A177522E" modified="2019-05-08" version="1">MSRRRSGKSKSAHSKPRAFDPREGKLKRWEKLSDIPLDEEDQFHVSRDKILLEDEDLGDDDEGDDDEVFALKGIPDDEEEDEDEDEVDAVEEPDHIRTPPKKSAKSKQKKGKTSPSSSEAESESEEEGWGNKKSAYYSSNAAQLESDDEEANELEEQEAKRLQAKARDGMAEGDFGLEDAIEGAVESDDLIVEAPAVVAQPLPKDKQSLLRHLEKTSPETLALARDWDDIAHSLVKTQQKLASLETEEPDPLSLGMIHMYYQALLTYSTVLAFYLHLAASEKYAQHPELLRAHPVLPRLLTLKQSVTTLEDLNFGLSDGEDEDDEDEDDLDVEQLWSVDQLKGLDEDELDQLIKEATQAVPDVNDSKAESKGEAKKIKAKRPKSDSTEQPPPKKKRKTESESKVIVPVFDLVEPDFTIKSSTSRRSYESAVTDVYGEATALQSADAADKRARQKSLRFHTSRIESTSARRQSARNNALGGDDDIPYRERKKQKEERLVREAAKTRGAGGDDLDDAEPEPQSTLKKRAREGEDEDKEDTGDDGYYELVQRKSKADKEKKKAEYDAAKLAARPNVDDGADGPRALTRAILKNKGLTPHRGKSVRNPRVKKRQKYEKAKKKLASQKAIYKGGLRETGKYEGEKSGISRVIKSVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMA6</accession>
    <name>A0A401GMA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0504190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614284.1">
        <property type="nucleotide sequence ID" value="XM_027758483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMA6"/>
    <dbReference type="STRING" id="139825.A0A401GMA6"/>
    <dbReference type="GeneID" id="38780288"/>
    <dbReference type="InParanoid" id="A0A401GMA6"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE83371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="528" mass="58036" checksum="9755AA07C4748B94" modified="2019-05-08" version="1">MRSFLIGSPSLSGRALSRLISLACSVAFILFGYEQGVMGGIITGPAFTQQFPSINTTTGNGNTQLQGFTVAIYNIGCWAGSLLTMVVGERLGRKKTIIVGATVLAIGTVIQCSSYSLAQLLVGRIITGTGNGIITSTIPVWHAELCKAESRGKFVTVELSTNVGGVAVAYWVDYGMGYVNSGAQWRFPIALQVFFALSTVSLVTFLPETPRWLLSHGMDAEAKDILTRLHVEENASAAERERLEIVAAIAQEREAQERLGGKGSISTIFTNGEQRFFYRTMLSVWAMIMQQLTGINLITYYAPYIFIKSVRFSQRLSALMSGFLSLFYWLSTLPPIFMIDRVGRRPLLLIGLIGMACSMFVLAGTTSVVSFAPGVVATVALFAYDFFFGIGWIPGPWLLASEYAPLTIRSQSAALATSATWIFTFLVAEITPVAIDNIRWKTYIIFGVFNVVFFPIVYYFYPETKGKTLEQIDLLFSGPKVLIDISQAELLEMQGKHIEMAVKARKVDVDEYDAEKMSTTHYIEGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMQ9</accession>
    <name>A0A401GMQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0505470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614409.1">
        <property type="nucleotide sequence ID" value="XM_027758608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMQ9"/>
    <dbReference type="GeneID" id="38780413"/>
    <dbReference type="InParanoid" id="A0A401GMQ9"/>
    <dbReference type="OrthoDB" id="3352285at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="327" mass="35636" checksum="5748BD8291F5AE23" modified="2019-05-08" version="1">MSTRPPPVRGGGALSFVSRSSLRPVVISIGVIAAIWSLIWAIGSFQTISTDKNHGQPKLASLAIVLGAIYVGVCVIEVLGIIAASVQHRFMVRVYALLSVVSSFAIVGAALVRVIVHFILKNDLISECETIVQGDEVFYQFGFWGPTYETKLTLDEATSYCKDSWNHDSFVEIIMLVIELLLSIFFTMIAFAYYRQVLDPTSAANVSRRAPATVTDPALESEYPSHYNPPYLGYDAPSVRYSPPPGMPPAPYDPIAKPPDYADEAGYGVGKGLTLSDTPPKGDDPFADFEHREAGDTVDKVDPFADTHEHGPGAGESRFVEERESLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMV8</accession>
    <name>A0A401GMV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sphingoid long chain base kinase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0506260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614484.1">
        <property type="nucleotide sequence ID" value="XM_027758683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMV8"/>
    <dbReference type="FunCoup" id="A0A401GMV8">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMV8"/>
    <dbReference type="GeneID" id="38780488"/>
    <dbReference type="InParanoid" id="A0A401GMV8"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="104"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE83571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="511" mass="55490" checksum="E040AB3EE638FEBA" modified="2019-05-08" version="1">MARTSHTLKLSGVRGGCIELTLTDAFLCVQRTGHFNRKEYETDTRNVLWAECAGTMVEISLLVRKSAKAAWSFVQLNGRCAHGEEGTACAFTDLLMTAAYAGTKRQRRLRVLVNPHSGSGNAVSNYSKKVEPVLRASRCLVDVTFTRDRGHATEIVKELPLDDFDAIVTVSGDGLIHEVMNGFAARADAEKAFRTPVAPIPCGSGNGLSLDLLGIQDGSDVFAAALNAVKGQPMSVDLMSVQQNTERVYSFMTQTVGLLADVDLGTENMRFLGSGRFLLGFLRGVITMKHCPVTLSVKVAESDKTQMVHALHASRARFLPQKSNPHHSQSPSYGSATSVDPNGKDPGSASTAALPALDYASSADTDGWITLTCPLLYVYAGKGPFVSREFMQFPVSVPDDGLIDVVAQEVGSRRELLESISTAPQGGNFWLEHQHYFKAHAYRIEPYKPGGCFAVDGEAYPFAPFQVEVHRGLATLLSPCGYYQAKFDFPSDYETRKDTDDEEAGCFVCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMY7</accession>
    <name>A0A401GMY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0506520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614510.1">
        <property type="nucleotide sequence ID" value="XM_027758709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMY7"/>
    <dbReference type="FunCoup" id="A0A401GMY7">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMY7"/>
    <dbReference type="GeneID" id="38780514"/>
    <dbReference type="InParanoid" id="A0A401GMY7"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="354" mass="38641" checksum="D951662062570B67" modified="2019-05-08" version="1">MSKVVFVGNVPYTMGEEQLIDVFKSVGQVVGFRLVFDRDTGKPKGYGFCEFSDHDTALSAVRNLNGQDIGGRPLRIDLADSDPFLEGKTTVRGELIDGGETRAQWREREREREDYRSRPYDPNAFLANLSPGVPVPLGSTALDTISQMLATANPSQILEVLAQMKAFVITHPEQARALLVAHPQLGYALFQALLLNKIVDPAILQRMLAATSASTSVPPQAQAPPPAPYPQAPPMQHPQPSFMQSMQAPAAPVHHPAAPVQPPSMYQQALPTHMQSVPPLQPSSYYHPPAPVAPPPQSQQAQPAAQATLPEFSSAQRDMLLSVLHLTPEQINTLPPAEREQIQQLRRQFLGSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GN93</accession>
    <name>A0A401GN93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0507380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614596.1">
        <property type="nucleotide sequence ID" value="XM_027758795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GN93"/>
    <dbReference type="GeneID" id="38780600"/>
    <dbReference type="InParanoid" id="A0A401GN93"/>
    <dbReference type="OrthoDB" id="3261714at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="552" mass="61394" checksum="63646E061B3F2618" modified="2019-05-08" version="1">MSARTPFIPQRTTSRPAPADQSKPSSNSAAHSDAFRPNGLLHPSSGSPPSADDSAYQQKQPDPPSLLNGINKPLNLSGLSKKKSSQPHKNTNSIKSGKHLDDSHTRSPKDQQALRVTVPRPSSPFFPNSSGFIATNSFRSTSLAHTQNTPSLISGDDFSSNNAHISTSASPASDGPLAATQGSDRIQYSQAFDSSALMRASARSSSRPSLEKIHEVAEEDLPLESYEAATREDERREFSVPAVEDLDNYPGRFATSSGRGNEDDAQQTLRRTSKRIQRPEDHEELEYGNVTKKYKMDTATNDFKAPPYSRNSPAASYLHDQGAITEHQRRRSHSHVNSQFEPPHADLVASQAQPDKQQVVQGLALHRLLGQDLDIYVEAHVEAYEQAKKKWSECSMDEWKTGADELASKFTEMLDFVKAHMISKLALYASLQSTVSAHRDVLSEREKVLKEARESLVREGGLAYVRRGKRESEPELITIKSVISMLRDPRDFVQYKICPLELRHLLRRRLHTASAPSAPLRTAVHPLIIPAHVRDTRVHAINVLAPRRRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GND9</accession>
    <name>A0A401GND9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0507680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614625.1">
        <property type="nucleotide sequence ID" value="XM_027758824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GND9"/>
    <dbReference type="STRING" id="139825.A0A401GND9"/>
    <dbReference type="GeneID" id="38780629"/>
    <dbReference type="InParanoid" id="A0A401GND9"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE83712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="369" mass="38962" checksum="8C9657079C2017BF" modified="2019-05-08" version="1">MACSLLRSAYCHPSNICRQCLTHSPAYKGTVTFPLGLYINGEFVDPVEGGTIDVMNPPTGKFITSIAAGTKADIDLAARAAKAAFKASWGFKTPGVERGKMLFKLADLVEQRIDEFAALDTLTNGKTFKTTAHGDCTSAIAILRYYAGWADKITGKTIETNDNKMTYTRHEPIGVVGQIIPWNVPMYSVAVKSGPALATGNTVVLKPSELTPLSVLLFCTLLADAGFPRGVVNVVNGYGPTAGQAISEHPLIGKVAFTGSTLTGRKIMEAAAKSNLKPVTLELGGKSPVMIFEDAASSTRTSPCAVVDGRGRARPGLDPGARARPQRADVNTGMQASTVDGSVSLPSYPAYVGHRVCHAIAFLGSLHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPB6</accession>
    <name>A0A401GPB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0506590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614517.1">
        <property type="nucleotide sequence ID" value="XM_027758716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPB6"/>
    <dbReference type="GeneID" id="38780521"/>
    <dbReference type="InParanoid" id="A0A401GPB6"/>
    <dbReference type="OrthoDB" id="3364747at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="157" mass="17658" checksum="559E0D16A5B3E643" modified="2019-05-08" version="1">MPLIGGSKPSDPEIRKAEKSAANEARHEQRNLEHAVKDLNKAEKSHEKGIKAVDKAQHALDEAVKEEHATAMELNKAEHKHDTAVADHRNAVKELELSKQHEQRLQEDVLQCRRTMEELRKQRDANDRTREGKLSQLHASSTRIIDEGSSRVPTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPM3</accession>
    <name>A0A401GPM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615023.1">
        <property type="nucleotide sequence ID" value="XM_027759222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPM3"/>
    <dbReference type="GeneID" id="38781027"/>
    <dbReference type="InParanoid" id="A0A401GPM3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7786" checksum="FF9B2712B7916358" modified="2019-05-08" version="1">MEMFIFLDQKNPTWHGMLEEQDDDISINSDSDYQKQEDEPEEVFYEDGSAPGDYQEDGDIDGEGSDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQ08</accession>
    <name>A0A401GQ08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0602180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615153.1">
        <property type="nucleotide sequence ID" value="XM_027759352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQ08"/>
    <dbReference type="STRING" id="139825.A0A401GQ08"/>
    <dbReference type="GeneID" id="38781157"/>
    <dbReference type="InParanoid" id="A0A401GQ08"/>
    <dbReference type="OrthoDB" id="2803164at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="329" mass="36949" checksum="C3A8E1AF50A29D9F" modified="2019-05-08" version="1">MVGLRLNQRGRTQDVNNVCKKIEDLLHGLKCRVGVEGFFCLVCNTTDFHMPLRWYFSSQELNKYLRGAIKKGWDPANIGALAEAFAVASCDFMSFLRTSKSKADWLKGEIRDKINTMLVEITRNSKAVMNYVNYERDIVLKYGITLQGWTHEKWANPSDLSTSPPPLRTLLAALESGTCKFEQLTSEELKKRTEEYDQKVAAGEAVARKKRKDTGGKHAGMRRKHRAEAEDADADMEDDDDDEVNEEEVLSACTGEKRPSDDANTSEQRPSDDANTGEQRPSNDMNTGEKRPSDDANAGSSKRRPSKRRHKTSSHTPKSAETIPSDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQK2</accession>
    <name>A0A401GQK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0600010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614937.1">
        <property type="nucleotide sequence ID" value="XM_027759136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQK2"/>
    <dbReference type="GeneID" id="38780941"/>
    <dbReference type="InParanoid" id="A0A401GQK2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019508769" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="68" mass="7822" checksum="4E0AB6A8BF68BB19" modified="2019-05-08" version="1" fragment="single">GFKFTSFLYTAWRHFWTMWTVLCFRVRRMAARDRYALFGVPRAAPDMPHLSCSVVPRPLTADAQAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR24</accession>
    <name>A0A401GR24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615600.1">
        <property type="nucleotide sequence ID" value="XM_027759799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR24"/>
    <dbReference type="GeneID" id="38781604"/>
    <dbReference type="InParanoid" id="A0A401GR24"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="700" mass="75634" checksum="12D3E1CD99AE79EF" modified="2019-05-08" version="1">MLDNFLLKHLFDPAHTTVCNYNGPSYFVYPEHCRTANLIGAASALGSHTVLKVRPWNIDTILVSAPPRVCHPVNTSRAIPLVGSLLELSEVPREVELAFVRDESVIVAWSCRPGALLGLIYLVNRVAEDLLYHTLHSSRPRISIPPPFEQNHWSSLAECDVSDASISVNHSKLSHISNGRNQIHLCDLPKGTATCDASAHSAIGVRVADAECDNPFTSGFSSLDTVLLGACSTLEPEGPFLANAPCPFPFSIPAYASSSSSGSPSPLSTPSTSPSAASIPSSSSSSSTPPLSSNYSLADATTASSQCPFATVSLADICPPPFYLSFQHVDEVPCDSPESDITPATCATPETGKAASTVIPSFQPGKPAKEPKPTPSSSGAASSSTTRLVKQLPRKVASRSTTSRAPAPPPKAPSPSKARVARAARTSRAVANTSFAGPSASTSHSSTSSHTHTRAPAPSQPRKSPRVVGQKTKRDAEEEESSQEGDELDEDEAEDVDMDLNEDEYQAEDDDDDEGEDEDADDDDYCQTSRQAPAKRRKCTTSHEAPVKRPARGGRRKRAVAKGKSGTFHCALCHCEFTRSTDTKRHIQSCCKDSRSYPYKCGFLCPYPCAREVTVDEMNSKLKEAEQMKKTQENLTFFYQFSEKLDEDGNVKYVQQTCFLRQDACMRHMSSVHARDGLYKLGDKPEPLKSDLPVPDGWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR66</accession>
    <name>A0A401GR66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0607080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615641.1">
        <property type="nucleotide sequence ID" value="XM_027759840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR66"/>
    <dbReference type="STRING" id="139825.A0A401GR66"/>
    <dbReference type="GeneID" id="38781645"/>
    <dbReference type="InParanoid" id="A0A401GR66"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE84728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="169" mass="18610" checksum="033D4081C0099A28" modified="2019-05-08" version="1">MLRTNQRIDKLAAARVDFTNRGMLNGSCLSEALRKLVAVNDSLSEKEDVEANADHLTIKPSNCDEQNDDGTISGPTILAYVDLAATIQQQHARSFAELAKEINQLKLPELIRQFLYDQLNPDNPRPASDIDINECPTLKGKISVHYSAAATYYASSDPCGVGGMHREHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GTY8</accession>
    <name>A0A401GTY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0801630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616556.1">
        <property type="nucleotide sequence ID" value="XM_027760755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GTY8"/>
    <dbReference type="STRING" id="139825.A0A401GTY8"/>
    <dbReference type="GeneID" id="38782560"/>
    <dbReference type="InParanoid" id="A0A401GTY8"/>
    <dbReference type="OrthoDB" id="3259156at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="160"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="584" mass="64597" checksum="EF647CDB14855780" modified="2019-05-08" version="1">MSFFRNRRQSPQQSLQEPGSPKPASVVSPTPSSTAKIRKRLTSLSLGGIKRTRSTTHKHCAAPPVGHTVQFPSGYARYGSESPSPTASLDIRMPTGLGRRASFTEKSEQEQQGRAERLRQERPKTTGGISAPDLSHSSQSGAGMLRWVDALTEDVTKDDGPAIMRMPVDLLNVMFSYMSRQELASLALVSRMFLLPALRALYSNLDLWHTADSRVEQCIALLASKRSFGGYVRRFVCRKLPATKNGAVSMSTVTFAIAFTNMYQLTSLTIPRFEAHLLLHTTFRLRRLTILAEFMSSDELRDFFSWLVSQPALTSLSLPNLVLRSLLNREDSGSPSNDTTQPSDTLMCPSQSFPHHLLSRLTHFHGPPVLGAVLVPGHPVASAVLRIRTTLYEGLRPSAIMSALARSSAPIKRLSIKATSNKVDARTLERIFMSAGAELGDRLEVLEVDWVLEDEILYKQILSVLPRFRSLRTLRLHRGSPPPPPRSPPPTFPLPPTSLSPTNIYPSPLPSPNSPLGSRPTTANSMSLDIPLPRAHERTHLSAWSRHCPSLRSVVFLSDAEWRISLRNLADPMSMYAFVGFVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUS5</accession>
    <name>A0A401GUS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0800010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616397.1">
        <property type="nucleotide sequence ID" value="XM_027760596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUS5"/>
    <dbReference type="STRING" id="139825.A0A401GUS5"/>
    <dbReference type="GeneID" id="38782401"/>
    <dbReference type="InParanoid" id="A0A401GUS5"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="14683" checksum="40610AE9FEF5D59E" modified="2019-05-08" version="1">MDYRDLIMHNLSTEFSDNISEAVRIVPMRLRVASRSPCLVPGYADRPTLHVEGETSGSSPSGHVRRLHGTVGVVADGSVRWCLYSTVDGGDADEWVTEGLQVGGLNSAMGVLGMWTGAQHERMDPLGPFWAWKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUT5</accession>
    <name>A0A401GUT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0676 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0800110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616407.1">
        <property type="nucleotide sequence ID" value="XM_027760606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUT5"/>
    <dbReference type="FunCoup" id="A0A401GUT5">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUT5"/>
    <dbReference type="GeneID" id="38782411"/>
    <dbReference type="InParanoid" id="A0A401GUT5"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE85494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="338" mass="37690" checksum="3C4464F4A9975544" modified="2019-05-08" version="1">MGSVHDAMSSLPIIDFANFGDGTSPDARKIGVQFYEACRDVGFAYLINTGIPQESIAEMFAWSKKLFDLPTGIKQKAPHPPEGSYHRGYSGVGVEQVSQMVFDPKELAAIRTKALDFKESFDMGYELGPRLKNIWLPEDDLPGFRAYAVHFFGLCRAFQTTKLLRALAIGMPGLPDDFFDQYHEKADNQLRLLHYPAAATDVFTSGQKGRINAHTDFGTGTMLFQDDCGGLEVESPNEPGKFIPAPPIPGAVVFNIGDFLMRWSNDTLKSTLHRVRAPPPKPDENGMTRERFSIPYFMTADRDKVIDCLPGCFGPEKPKKYEPINAGQYIDMRLNATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV12</accession>
    <name>A0A401GV12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0805660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616955.1">
        <property type="nucleotide sequence ID" value="XM_027761154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV12"/>
    <dbReference type="GeneID" id="38782959"/>
    <dbReference type="InParanoid" id="A0A401GV12"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="104" mass="11474" checksum="E504D219D3A4C911" modified="2019-05-08" version="1">MCEDLGELVTTLDEVQRKPPTLKKRILKWLRRAPDARHGYPEERRLKQSVSLPLGDYAGRTRDYIERISPGFTSSLAPGLGTAASAALSIASSLSSSIINDYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV70</accession>
    <name>A0A401GV70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0806420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617031.1">
        <property type="nucleotide sequence ID" value="XM_027761230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV70"/>
    <dbReference type="GeneID" id="38783035"/>
    <dbReference type="InParanoid" id="A0A401GV70"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="209" mass="22810" checksum="E0E81109E5208A4E" modified="2019-05-08" version="1">MHSRHPRVPQGPAKPQPTSLHPPPTLDARKPSVANDVAAIVAAMSPWRHLHPSHLALPGRRTQLFGGAFVFGGLRAVQPRSCRAGHRGATMMHSCHLTVAKAPRSPTPPPRTLPRRSSMRAGPPRRTMALRSSLWQPRCYDPANLPPRSLQAPTLARVTSRHHPPTLLDLRRPSAANDRAAVITPAAAVQRPHRPPSSRSQGFRSGTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV81</accession>
    <name>A0A401GV81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0900180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617054.1">
        <property type="nucleotide sequence ID" value="XM_027761253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV81"/>
    <dbReference type="FunCoup" id="A0A401GV81">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GV81"/>
    <dbReference type="GeneID" id="38783058"/>
    <dbReference type="InParanoid" id="A0A401GV81"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE86141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="726" mass="81921" checksum="15BB45CD1FE50AF0" modified="2019-05-08" version="1">MQSEPHAGPANLLPPLISKGGVDDFRRSGRTLAAGISPRDDTIAIYATPNADPQTLQAQNASYPEEQNIYLASAQHAPSSERRVFVTDTSVIFAALQRLLTNVRKKDIQVMDHEPTLEALNKLAYDYINFCKECCAYASQSITRTEPLQFSAEHYAKLFSCFSLFTLLYLPDAGHDRAPVGDELMEWLNTHFIQPSTEEGDHLSTLEKPWEDDTFWPYLTRTTLRGMSKASAFFLKELSRHPSMFLQRIAAGLLPLVTNHPRLYQYNAERDFVIAYRRWRDRVKALRLELNRIPDAAREDEAGNWWERMSAIVGLLEGRPDITKRICVDLGADWKEVCVAWSVFVDTRLRRQDMPDVVAHVLNEMPADPTNMEDVIHTSLLLGKPKSVLVEAAQMDIWLAAHFADMMEPLELIESEPDDSDLSLRQQYVLSYTEYLRSDPALWRITVDYMCTCEDIGKQMADEVLVRVPLRLQAPRDSSDASAEHERIRTGNLAGVLKDVAATCFEHQREGVRRTVCRIAAQTFLREQEYGMAVSFCTSAEDWPGLGRIVDRVLDDYITQGPEKFARHVAGIAPSLQVLRAEVGANSVFVHRLLFAVRLAEFHQRRINGDLEEAAADLVAMLREDIAPKSWWAVLLSNAVELLLYGERMLFTTDEACLLLCRLEEIHIRAAQGASEDYLAVLARTTKSGGEKHALQRLQTVRLALARYYARCGVIGVGGKNGIHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW11</accession>
    <name>A0A401GW11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0902960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617330.1">
        <property type="nucleotide sequence ID" value="XM_027761529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW11"/>
    <dbReference type="STRING" id="139825.A0A401GW11"/>
    <dbReference type="GeneID" id="38783334"/>
    <dbReference type="InParanoid" id="A0A401GW11"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052096">
        <property type="entry name" value="Endocannabinoid_amidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45847:SF6">
        <property type="entry name" value="FATTY ACID AMIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="577" mass="63016" checksum="180CC28BF2D74BB9" modified="2019-05-08" version="1">MWPFSSSYSTGNISLFKQAQRDERLSSVSMAVATSVNTSAILSAGASEIVKHIEIGEWTASQVLEAYIQRAAFAHQSTNCLTEVMFADAREEARALDNEFEITKTVKGPLHGVPISFKDTFDVKGYDSTIGFGELANNPRTADAELVSLARAAGGIPFVKTNVCQTMMTFECANPIWGVTVHPQNKRYTSGGSSGGEAALIAMGGSPLGFGNDIGGSLRIPAAYCGIYSLRPGTWRISGVGMTSALEGFEGIPTVMGPVCRSVDDVELACRVVFGKGSNREVSPMPFRDVQIPAKLRFGYYISDGFIKASPACQRAVRETVEALMHQGHECIPIVVPEPLTHVELFAGLTSADGYKTLLAGVGRDPTDPGLFLTTLGPRLFGWFRSLAVWIISTFFGDDIFARCMRMSRTRSVAEYWQLVAKRDVYKQLFYDEVWEKHQLDGIIAPVQALPQAQHGTCAKASVLAAGTFLYNLLNLPVGVVPVSRVDPKRDQVTEEWSNPRIGEGHGSPLFERLLYGRGGLYDPVDMAGMPTAVQVIGRQWEDEKVVGMMRVVDRALGPRWLLHSEVKDSVNLRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWE2</accession>
    <name>A0A401GWE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0903820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617416.1">
        <property type="nucleotide sequence ID" value="XM_027761615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWE2"/>
    <dbReference type="FunCoup" id="A0A401GWE2">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GWE2"/>
    <dbReference type="GeneID" id="38783420"/>
    <dbReference type="InParanoid" id="A0A401GWE2"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="167"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="383"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE86503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="468" mass="51687" checksum="65669DC2A345D1B6" modified="2019-05-08" version="1">MSRLSLAQQLAELAEPTPLDLDPEDVHAGILPEDLSAIDDSAAREHYVDVAPSALRRLQESVSDPKYLGIRTTRKQLYEDLDQEPESEHEEELPDESVSGKDDDQNEIPSEEEEPELNDGQDGSSSHEGPPNGPDAAQSDTSYAQPVHESQEIGDLASALRKTREGDLKKGKAVARQLVLWDALLDARIQLQKAVSATNRLPTAAHLSDFVRHPSAREALDSMLEEAAVLSEDLFKLQEGLLESNESIHAPPRKRQKTGHDHTTPEEYSDRFADLSEAASALEAAYHSHVVTTLGKWSAKVQAVAPNVLLGNRNAFNKDDKGKAGVVSVIDDTLRNDGGKLLSRTRTPRGKNQRLGAAPTEMDDADGPQDDEDAEIFDDTDFYQQLLRDVIRARGGNDNGVEQDWMAQQREGKARRKMRIDTKASKGRKLRYEVHAKLQNYMVPVPVAHGDWHEEQIDALFSSLLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GX63</accession>
    <name>A0A401GX63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1000390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617710.1">
        <property type="nucleotide sequence ID" value="XM_027761909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GX63"/>
    <dbReference type="GeneID" id="38783714"/>
    <dbReference type="InParanoid" id="A0A401GX63"/>
    <dbReference type="OrthoDB" id="3232221at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="136" mass="15468" checksum="6EFB62CB71BC1613" modified="2019-05-08" version="1">MATHQMIALYNALRHIRDIRSKIEATDGALSKEVFSTTENIPDRNLDNARSAIGLDFQFLVQTIRSVKKSDPLVKAYPDIHYNLRQQNKRRKWLTHEYKLTVPIQWGDIADGVYDDIPRIEAALLSALVANGVPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXB9</accession>
    <name>A0A401GXB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1000740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617745.1">
        <property type="nucleotide sequence ID" value="XM_027761944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXB9"/>
    <dbReference type="FunCoup" id="A0A401GXB9">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXB9"/>
    <dbReference type="GeneID" id="38783749"/>
    <dbReference type="InParanoid" id="A0A401GXB9"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="208" mass="23606" checksum="B2B0B66DD2BB932C" modified="2019-05-08" version="1">MLSRLRSILQSFISVSRSQALQNGRGVSSVTMSGGNPEIATFAAGCFWGVEHIFLKYYPIAEQKGILKTAVGYTGGKDDAKDPNYRQVCTGTTDHAESLRIEFDPNVVEYDELVEFFYRTHDPTTVNSQGADQGTQYRSAIFYHSPEQFDIAKRVTEEVQKKHFDPIGKKIVTQIVPAGPWYDAEEYHQEYLHKNPSGYQCPTHHLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXS5</accession>
    <name>A0A401GXS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1002530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617920.1">
        <property type="nucleotide sequence ID" value="XM_027762119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXS5"/>
    <dbReference type="FunCoup" id="A0A401GXS5">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GXS5"/>
    <dbReference type="GeneID" id="38783924"/>
    <dbReference type="InParanoid" id="A0A401GXS5"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="194"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="286" mass="31347" checksum="B0D1ABA657BB43DE" modified="2019-05-08" version="1">MSKKEKPLHSLVAGSTAGAIEALVTYPTEFVKTRSQFSGKRESPFAIIRTTLQTKGVKGLYSGCMALVVGNSVKAGVRFVSYDQFKHMLADQEGKVTAPRSLAAGLGAGMMEAIFAVTPSETIKTKLIDDAKNPTPKYRGLVHGTAAIVREEGLRGIYRGLFPVMMRQGANSAVRFTTYTSLKQFISVRPGQQLSSGVTFGIGAIAGLVTVYTTMPFDVIKTRMQSLEARQAYRNSFHCAYRIFTEEGILRFWTGTTPRLARLVLSGGIIFTVYENVIRLLRGREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXY1</accession>
    <name>A0A401GXY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1002870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617953.1">
        <property type="nucleotide sequence ID" value="XM_027762152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXY1"/>
    <dbReference type="STRING" id="139825.A0A401GXY1"/>
    <dbReference type="GeneID" id="38783957"/>
    <dbReference type="InParanoid" id="A0A401GXY1"/>
    <dbReference type="OrthoDB" id="5392263at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019357554" evidence="2">
        <location>
            <begin position="34"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE87040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="595" mass="65266" checksum="9837B592818D895E" modified="2019-05-08" version="1">MAISWFTRVACLLRHGSIPHLVLALAFIQPVLASVNFDQCFAAIQSGSYGQDGGTDNHGNPVPVENATAITYSLCLSACGSDQEPFSWSTFSQQFSAWLLPYLALVSQLPFGAKHRLGNLTSVYLTVGSPTLAAYSLALTVLNGRWVAGRFSRIAYPNAQKAARILGSLQQAQLRISYDDALLSSLVVLHENNAWWDELADALDYTHTWSIAALTQIVWVVAAYVFTVVQSLTDINSNINSNGQGVGSVWLWLLPIVGGWLQLSPKCDTVRLRRAFDKTNPLPFVTTPTGEVVKVSSITDERALSIDSYADGFVRDGHWLASVTRDQELSAPIFNYARFLPWVQRVEDVAAAFRAAAMRAKNHIPVSGQLWTLSEDGSIHRNNRTGTLAQVMAYTEPPVYMRRSHWGQGVFTRMFIASVLALSLQWGTTGAAVIVVWFTPTIGLGCRSGAYLIYGIVSTMVWLILITSSALAHHASPRSYHASSPLANMRSVRLAGMLAIALRRVGKTLAFMNAVWIVLACVFQFSNVFDRCYCNSSVTGLGRNAYDVLVNTETDLVRMRLAWAAGVALASFVALAFSFFVNLIKDPEDEGWFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYZ0</accession>
    <name>A0A401GYZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1100470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618285.1">
        <property type="nucleotide sequence ID" value="XM_027762484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYZ0"/>
    <dbReference type="GeneID" id="38784289"/>
    <dbReference type="InParanoid" id="A0A401GYZ0"/>
    <dbReference type="OrthoDB" id="2773026at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104:SF2">
        <property type="entry name" value="CXC3 LIKE CYSTEINE CLUSTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104">
        <property type="entry name" value="SI:DKEY-29D5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="29221" checksum="BA16C55029F14906" modified="2019-05-08" version="1">MVDLQKGEQFGHMDFALAGALAGLEELQHIIFTYDVACIYKINILKRFGAQFPQLMPLLDRIQMLLPKMHMLAHKEACQVLYALCYMWGTGLTHGESVEHPWAEHNQAGLSTREMGAGHRHDALNDIHNYWNWQKVENVGAFLARKVNEAFKGQEEKTQLYDALTEVAGAEKVSTWQQMDVDPKQKGKRVESVYLLNDAKVPTAGRAYQELAKMEIQPRDGQMDLAVGKAPSGAAQFLKTEAVGTGISPSKAQGWRQHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ23</accession>
    <name>A0A401GZ23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1100760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618313.1">
        <property type="nucleotide sequence ID" value="XM_027762512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ23"/>
    <dbReference type="GeneID" id="38784317"/>
    <dbReference type="InParanoid" id="A0A401GZ23"/>
    <dbReference type="OrthoDB" id="2803395at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="315" mass="36286" checksum="80594D6A8FF608F1" modified="2019-05-08" version="1">MTRRRREKDFLDVFPNELLLMIKARIAETDLRTHVCFYNSSTRIAGMYGNVWEQEEYWKKLCWLNGLGLLPGESCKSVSWKQIAFECVEDDGFCDLPDCGGNALVKNVALMAAADYNLERPTQALAHKEGGPDLDCSPLLSHIKFRSNQEWSWRMKPDYDAQLYVRPSEAQSSWGRRLHAHPIACRSFATFPPIQRLNFSELYGLEFHPTKRTTGVTVWDVQSTLQKKLDTGILASGVAEFLEWHETNVPKHWDVRTMLNELCTLRGMLSVVRWDGMEISIDDDDDGPYFVIELVRIERDDDDDESDDEYSDISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H056</accession>
    <name>A0A401H056_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1200300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618718.1">
        <property type="nucleotide sequence ID" value="XM_027762917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H056"/>
    <dbReference type="STRING" id="139825.A0A401H056"/>
    <dbReference type="GeneID" id="38784722"/>
    <dbReference type="InParanoid" id="A0A401H056"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="893" mass="94714" checksum="02B853F1706B9B7F" modified="2019-05-08" version="1">MSQLSFKGQTVVVTGAGGGLGKAYSLLFAARGANVVVNDVSQAAAQKVVEEIVNAGGKAVTNTSSVADGAAVIKAAVDAFGTVTILINNAGILRDKGFKNMSDQEWDQVNLVHLKGSFSCTKAAWPIFCKQGFGRIVNTASAAGLYGNFGQANYSAAKMGLVGFTKALALEGAKYGIKATVIAPMAASAMTETVMPPEMLANLKPAFVAPFVAAVTHPDGPDASGKVFEVGAGYVAEIRWERSKGTVFKADSSFTPSAVQEKWTEIQDFDEHGHPQGLPDVDAREKLSLAEKLSTNAQSSSEVRFDDKTVIVTGAGAGLGRAYALMYARLGANVVVNDINEKVANSVVNEIKKAGGKAVAAVASVEDGEGIVKVALNAFGGVHVLVANAGLVRPNNFGNMTDKEWDDVFAVHMRGTYKCAKALWPIFQKQKYGRIVTTSSQAGLYGMAGLVNYSAAKAAILGFTRTLAIEGAKYNILANIVIPSAGPTLGLGRAYTNIEALKEEYVAPVVGYLSSEANETTGGLFQIAAGWVAQIRWQRAGGHGFSTNQPLTPETIISKWGMLTDFTDGRATNPASTQEAMEQLVENFGNTSDDSTYTDPEDSELVATAKRNVPDPEDYSYTERDVILYNIGIGATERELQWTFEGDDAFSAISTFGVIPQFPASMGMSLDWLPNYNPAKLLHGEQYLAIKAPIPTSGNFVNEARLLEVLDKGKAAAVTTIVETKDKATGKVIFENQSTVFIRGAGGFGGKRVGDDRGAASAANTPPQRKPDATLEEKTLPVQAALYRLSGDYNPLHILPEFAAVGGFDRPILHGLCFFGIAGKHVLKAFGDFKDIKVRFAGVVYPGETLVTEMWKEGAKIIFTMKVKERGTTVLAAAAATLSNPSSPLKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0A0</accession>
    <name>A0A401H0A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Ergosterol biosynthetic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1200340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618722.1">
        <property type="nucleotide sequence ID" value="XM_027762921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0A0"/>
    <dbReference type="FunCoup" id="A0A401H0A0">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H0A0"/>
    <dbReference type="GeneID" id="38784726"/>
    <dbReference type="InParanoid" id="A0A401H0A0"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="135" mass="15396" checksum="C89DA2505CADF556" modified="2019-05-08" version="1">MALIDFLPQANGLLPKWQLVVAVMAVFNTVQNFVTLKFTRRIYNASHLVSPLQARTFAIWTLTSAVIRLYAAYNINSKPIYDMTIFSYLFAFAHFGSELLIFRTAKINVAVLSPVFVSTISLAWMLSQYDFYVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H0Y7</accession>
    <name>A0A401H0Y7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1202790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618963.1">
        <property type="nucleotide sequence ID" value="XM_027763162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H0Y7"/>
    <dbReference type="STRING" id="139825.A0A401H0Y7"/>
    <dbReference type="GeneID" id="38784967"/>
    <dbReference type="InParanoid" id="A0A401H0Y7"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE88050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="245" mass="27224" checksum="6E160A0F8121EE2A" modified="2019-05-08" version="1">MAPTYTHPAAANYHSPPSHAPSKPRGARVCDQCGTFEQPSTGRFRLCGGCMVTQYCSQECQKAHWPSHKTICQHTASTVAAVKEPGAHDDNLAKNLRRFCSSYAELLGWAGFQALQLKRLPSNLRHKALMIEIEYHQSASDPLRRFSVKGTQIIPRSYVADNDPVVGSDILRREERCRKMGGIGTAVIVIQCSDVNQVMPVEVDAPSKISWDTRDDWADVLRHFVESGRTDFKPISTTPRGIVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1D0</accession>
    <name>A0A401H1D0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1300520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619150.1">
        <property type="nucleotide sequence ID" value="XM_027763349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1D0"/>
    <dbReference type="GeneID" id="38785154"/>
    <dbReference type="InParanoid" id="A0A401H1D0"/>
    <dbReference type="OrthoDB" id="3174721at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="2">
        <location>
            <begin position="99"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="272" mass="30244" checksum="A422CCF5A1F85639" modified="2019-05-08" version="1">MILLQSEWEDDSHLQESSRLPSYYDAVASRLFVQQPAFAASSPDLSAHQRRTSSDFPPTQVAGSSSGPPANPSSPLPRHFNPVVYTFAQNSFNSMMLSADPQQSPLCYHVSVQMNCFIPSSYITTVRRGNSEDGEMVGSFEMGISQKRSTVTIDNTEKLAGIVLSKTGGKSKHIWQWRWHTNSRLHLSWLCDSPVRYCYLSHHVGTSKAVLLASFTPHSLTPRADGHPSPPATLKVFPEGQRYADHIVMSALILERKRLTPDGDKALRSLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1X6</accession>
    <name>A0A401H1X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1301750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619273.1">
        <property type="nucleotide sequence ID" value="XM_027763472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1X6"/>
    <dbReference type="GeneID" id="38785277"/>
    <dbReference type="InParanoid" id="A0A401H1X6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="66" mass="7211" checksum="0AA9950DDF9041C4" modified="2019-05-08" version="1">MSPEPSSGEETAGEEHFMDQYVREGEEVDWVHVRGHENAHGNSNGNGNGNEIENGEVADNPDDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1X8</accession>
    <name>A0A401H1X8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1302500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619348.1">
        <property type="nucleotide sequence ID" value="XM_027763547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1X8"/>
    <dbReference type="STRING" id="139825.A0A401H1X8"/>
    <dbReference type="GeneID" id="38785352"/>
    <dbReference type="InParanoid" id="A0A401H1X8"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="66267" checksum="AEFA2AB7B86139EC" modified="2019-05-08" version="1">MAASLSSLPMHGLSTWSSLTSAMYHTPSGLLFPRGSCRPFHHTREDVDHVLPQVSCSSGERYGSICASPLPAGPSAVSGPQYSYTHGGSVCRLASQSYLPVFDWLGDCQQRPSQYIVEKTCEMICYLWFSSLPSSSSPSKRNCPDPQQPQPYFPHSSSSTASLQFSVSPAFVRFMQKVLETTQVSQSVIVLSLHYIYRMKARNRFTTGQAGSEYRVALAALMMANKFVDDNTYTNKTWAEVSGIGLAEVNKMEREFLLGIDFGLYVDETTYDSWLNLLKGLTMAKERESQHWHRSRWRARPTPLSKAQFHRSTSMYSPTSHSTSHRARSSSPSRRSAGCKFPCSEPHKQHNVPYVSSSLSGLKRTAADAFCLAPTPRLPASNSVPRVNGLRLEIPQPDLSTREKPSPSEPLQLLSKLSLGASPVDGEVVPTWASSAMQETVPQTLVSAYRVDERIQHAPPQNLYFYTLACSPMEERNSRKARLHYHQPPAPIPTVHHIHAPVPMMVQSASASPCDVHRHLPPAPVLPPFSEFSREPPSSYGVDLANQPPADQGRAYTLQDHSIPSAPFANAGPPGYQFYFNSSPDAPFALYRPRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2I0</accession>
    <name>A0A401H2I0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon 17.6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1304110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619506.1">
        <property type="nucleotide sequence ID" value="XM_027763705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2I0"/>
    <dbReference type="STRING" id="139825.A0A401H2I0"/>
    <dbReference type="GeneID" id="38785510"/>
    <dbReference type="InParanoid" id="A0A401H2I0"/>
    <dbReference type="OrthoDB" id="3232518at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="280"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="393" mass="44337" checksum="5F73C8C5D183CEAB" modified="2019-05-08" version="1">MLIDCGSPSVLIRDDLASTLHLHHFKLRKLFPLGDAWGAGEQVSHEWVKLRVSSADSSWTSITCQAIIVPSLCVPVLLGNLFLKFNHLIIDLEHPSIIDKRTNFDLLHPPSISPPSVLLPPRERRNATAEDSELIAHHQLALHRDIMCDLLLNTPPVPPITSSSISVIASICECVEDLAFLATLTHENADMKSRFADLFPLDIPNLEELPTNVYHHFRLKDPNLIITRCQYDCPKKYREAWKMLLQQHLDAGRMRPSSSPYASPSFLIPKADPTALPCWVNDYRVLNANIIPDVYPLPSIQEILSDCGKGTIWGKLNMTNSFFQTHIHPDDIPYTAVTTPFSLCEWTVMPQGCRNAPVSHQSRIFKALRPYIGSICHVYLDDIIIWSSLLDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2Z2</accession>
    <name>A0A401H2Z2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1401860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619694.1">
        <property type="nucleotide sequence ID" value="XM_027763893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2Z2"/>
    <dbReference type="STRING" id="139825.A0A401H2Z2"/>
    <dbReference type="GeneID" id="38785698"/>
    <dbReference type="InParanoid" id="A0A401H2Z2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019491035" evidence="1">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="223" mass="24738" checksum="DF5C46F8B202FE52" modified="2019-05-08" version="1">MMQGFLSFLHGVISSVLSLVYGQPEVDKLTSEDDQLTGKYKHRHVQALLASTDVKNDHWMAVEFAALHALLPCNAETSRWYCPRPIRPDGSSKQADDAVGDILTESGPFETVLFDSSPGGIARSFRDGLVQAGRDLSSEDMLVVALIGARPWGSSYKLSPEGQDIFSAGEFRARFENFKCKIVFIIPCGDAGHWRRPRWTVLTAAESTGEPRVFTDIYRELRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H349</accession>
    <name>A0A401H349_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase andH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1402250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619732.1">
        <property type="nucleotide sequence ID" value="XM_027763931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H349"/>
    <dbReference type="STRING" id="139825.A0A401H349"/>
    <dbReference type="GeneID" id="38785736"/>
    <dbReference type="InParanoid" id="A0A401H349"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="33390" checksum="795DDFA354FF7B76" modified="2019-05-08" version="1">MPSLSAVRAANAAFSPSYIPVAIFVGGTSGIGQGVAEAFARHTHGNAHIILCGRNRAAAEAIIASFPKPTSPSALHEFVQCDASRMKNIEATTQELRARLPKVNFLVLSPGIMTMRGRNETPEGIDYKLALHYYARWKFTRDLLPLLAKAKDGGEDAKVLSVLAAGKGGPIDVNDLGLKKTFSLKNAALGATTYNDLMVESFAQQQPNIAFTHSYPGIVRTGLFSSSHWLLRPAAAAVTYATYPFSVDIETCGEYMLYALMQGQKGAYRRDEHGDDIGKKNYYGSDEERTRLWDHTVEEVDRASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Y2</accession>
    <name>A0A401H3Y2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_1501250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620035.1">
        <property type="nucleotide sequence ID" value="XM_027764234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Y2"/>
    <dbReference type="FunCoup" id="A0A401H3Y2">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H3Y2"/>
    <dbReference type="GeneID" id="38786039"/>
    <dbReference type="InParanoid" id="A0A401H3Y2"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="44"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE89122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="416" mass="44527" checksum="DDB73F0703C80F2B" modified="2019-05-08" version="1">MPILGLAPSLYPTAPAHFDIEKVIRPNILTLHPYRCARDDYSEGILLDANENSLGHSIPAAPADSELDPELRSTLSLDLHRYPSPRNDPIRERLASLRALPSTDYVFLGVGSDEVIDLLMRVCVAPGREKILITPPTYGMYKVCAQVNDVGIVECPLELSGAHGEGGEAGRFSLKVEEMKAAIGADPSIKLVILCSPGNPTGTLISLSAIRTLLEYEKFKGVVVVDEAYIDFAPEGSSAAALVKEYANLCVTQTLSKSFGLAAIRLGMALAHPSLIQILMNTKAPYNISAPTASLALSALSPSAVASMSQKVSALCKQRDLLLQKLAMLGPLGLGAAIGGNNANFIVVPVLEKNSSGKPDNVRAQRVYKTLAEEEGVVVRYRGSEPGCVGCLRITVGNVQENDIVLKKFEEILKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H465</accession>
    <name>A0A401H465_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620148.1">
        <property type="nucleotide sequence ID" value="XM_027764347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H465"/>
    <dbReference type="GeneID" id="38786152"/>
    <dbReference type="InParanoid" id="A0A401H465"/>
    <dbReference type="OrthoDB" id="2692698at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="603" mass="65244" checksum="6C5261A7F4B9E307" modified="2019-05-08" version="1">MNSILSTSRIFPGMKRRHRPKSKPEISSPRAKPLDILPELSEEDEGRQSFSSVSSFDSTLPKYYASRSVGGSATLGNRLSVAERKRDSRRVVLTGAEGLSFEDFFPSSSAPQRPPPAPAPLLLPDNVSSRESPLDDINLRFSGLGISLDFPSPPPDRSSSSIHPLVPNRPTHSPTPSMSSIHTYNTSSSSSSSRSRAIELTPPTSEDECLSSLKRAPALKSRRASVLFMKSVPDLNHASVSASAAEEDVDEDAKWFAHDISDVVAFSSRDLPSFSASLAASSSRADPSARPDSLVLPTRTGRSRHSKPLPNLPRRPSLQLDPTFPHRRKSFLIPDRPPPPPPIVVSPSSMEEETEELLAQLASAALNSGFVGTGLVSRGDGYLTPVSMPPTPSSTYIVSTPHLRPPPRTSLPADIHDLPDEAPWTPGAGEVEVEISPEIEGENAQGWPSTPQSVSVYSQASMSVDTLQLSPMSSFDFEVEIVPGECPAIPDTPAARIRPREGAQPDRVLRSRWSSSTLGSAVERPSSASFWIPRFNLSPTKKNAAKRIDPQKTPVSPGKQSFESDAGMNRRESRNSRMSSDSGDSSASCGLRRKPIPVEIFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H466</accession>
    <name>A0A401H466_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1502350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620140.1">
        <property type="nucleotide sequence ID" value="XM_027764339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H466"/>
    <dbReference type="GeneID" id="38786144"/>
    <dbReference type="InParanoid" id="A0A401H466"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="94" mass="11002" checksum="405EC88A28F63287" modified="2019-05-08" version="1">MREEPQATRWTYILFFPFTAALGSTLWNQWDVFDEMFEHSWNGKMCFVMFLLALCAAVFDFGTILGKNLPPFASNITACMPMVFNFFRGMRLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4J9</accession>
    <name>A0A401H4J9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1600050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620257.1">
        <property type="nucleotide sequence ID" value="XM_027764456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4J9"/>
    <dbReference type="STRING" id="139825.A0A401H4J9"/>
    <dbReference type="GeneID" id="38786261"/>
    <dbReference type="InParanoid" id="A0A401H4J9"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48311" checksum="4622CB938346C24E" modified="2019-05-08" version="1">MTNGQSSPVVPKLPHELMDRIIDLCDLRSTLYSCSLVCRAWVPRSQFHLFKVMLIGSLREFKSIVRAAETPHLRPLFAVTSSLDITGYSDYANQRKWIQTMALRLGEPFSGVTSLSMSGIDWGSPTLPPNVLATGFASFTGTVKMVLSDCKFSTFGVFRRIISAFPNLRELHLYHLKIRSNPSPQFLEAVAGSPRPRLESLTTIDVCYALYDWLSVTPSIRALHRLELNTATDQMESEASQRMISLVGEHLKDLRVKLTNENQVKSFCSSLCLTKCADLEILHLILPTGIDTLDIHSYLAALLSQISPSSRLQHLVFSTRLNLEGDTIDYYRLGPVDKLLSHSHFRNLCLVCAEVLVKFNLPLGVTELHLQQGVENALSDLVNRNVTVRCLVFPEYEDQSSEDEGNVLEDNASRTIAMPDDVERDGQEGGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H554</accession>
    <name>A0A401H554_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1602290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620480.1">
        <property type="nucleotide sequence ID" value="XM_027764679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H554"/>
    <dbReference type="GeneID" id="38786484"/>
    <dbReference type="InParanoid" id="A0A401H554"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="108" mass="11910" checksum="02E45EA16532DE03" modified="2019-05-08" version="1">MEVLLYQMPDYSLHGRPPWTLEPDSIVAQQNGTIVTPLRVMCAELTDSKTLKSMQRRTSLFALSGVNASTAPTTLPLDETSVANVKTIVDKQVLDTTHLIDPTVLDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5J6</accession>
    <name>A0A401H5J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase citE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1700420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620631.1">
        <property type="nucleotide sequence ID" value="XM_027764830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5J6"/>
    <dbReference type="STRING" id="139825.A0A401H5J6"/>
    <dbReference type="GeneID" id="38786635"/>
    <dbReference type="InParanoid" id="A0A401H5J6"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF37">
        <property type="entry name" value="CLAVALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="316" mass="34144" checksum="C4D2B6486CE02610" modified="2019-05-08" version="1">MSSYPSIVFCAMSESTMPSGEPPDFTLDPHTGLTFVPTVRHDTYPAIDISKANLVGKVVLVTGASKGIGKGIAIAFAKAGVSSLVLVARSNMTALETECLTAQRPGQSLKVLALSGFDTTDPTQVADAAKKVKETFGRLDILVNNAGLVEPLHLVADSDPAEWWKVWEVNIRGTYNVTRAFLPLLIECGGDKTIINMSSFSAHLIVPTCSAYLTSKLAILRLTELVALEYGSQGVIAYAVHPGSIPTDITASIGEKYQEVVVDTLASATDTLVWLVKERRDWLSGRYVSCQWDVEELLAKKQEIVAGDKLKVRMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H620</accession>
    <name>A0A401H620_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1701540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620742.1">
        <property type="nucleotide sequence ID" value="XM_027764941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H620"/>
    <dbReference type="GeneID" id="38786746"/>
    <dbReference type="InParanoid" id="A0A401H620"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="141" mass="15508" checksum="0386110BF887F8A4" modified="2019-05-08" version="1">MCWDRDYALVLPSTTLTRDYINLFPKVLKPCGSFNAAKIVFYEKGTFTSEANYGGTTEKVRRIWGGLEHNGVSMWPMNGAKEKDSEEDSGGENLGYGFLAIHTSSKNLPHALSGCSKSGIYAASGKQSRASSRQKVGTWRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H683</accession>
    <name>A0A401H683_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1702600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620847.1">
        <property type="nucleotide sequence ID" value="XM_027765046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H683"/>
    <dbReference type="STRING" id="139825.A0A401H683"/>
    <dbReference type="GeneID" id="38786851"/>
    <dbReference type="InParanoid" id="A0A401H683"/>
    <dbReference type="OrthoDB" id="8959079at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="343"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE89934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="662" mass="75861" checksum="BE786491C8785654" modified="2019-05-08" version="1">MARVILSKSHEYADDDPGLSLDYFCRDLELYSSRGKHKLVQVDHYKEKSRYDHEFLVFEITHGNYKSGSGKDNIYLRMERRPSGQTPLHTAGSFQRVTNDTIKRVRPDFDWSPYYHLFTVSRHPEKELSLSDICKMYQPIRIISPTYDPVSHNCYWFCNKFLQNLAEELQVSGCPGKDYRLRSTFAVGFTRVYPNRLARSALFSFGPAEDAGETSGECWCLPVMIPWRASKAVKRKASEGGSAAQVIEKPSDGLISILPTQSLPRVVAGPSQEKYRINYDSAPDITAERENVTPNRRTVWELDETRLMTLEDVLQQKISWQPEAVEAVAHAITVSTAKKKTNRPIASLIFAGPAGRQQRDVAEALAQELFGNCSLIIEILKIKSSYFGDEVWFSTGCYPRRESHFHYDSFGGEQLLQFVNQNPRCCILVTERIENIPPKILEVFLRILDQSQIHDQDRVVDFRETVLILSTGVADRFLESQVGEIPEEKRRKIDETIRCELEKIIQAKLDGSSPSFLDWFSRFTIAPFRALWDPEAKKEIIQKEVQDLQLCTDVSIHVNVKAEKWLMKRGVDFEHGANLASELMSQRLLHRINEGDVRRGDRVEFRMNARSNALRCVVPTDDFWSRFLPTLSPTDDAREFNFTSTAGPVFPTEEYMTEIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6A9</accession>
    <name>A0A401H6A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0503390</name>
        <name evidence="3" type="ORF">SCP_1703030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614204.1">
        <property type="nucleotide sequence ID" value="XM_027758403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6A9"/>
    <dbReference type="GeneID" id="38780208"/>
    <dbReference type="InParanoid" id="A0A401H6A9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE89977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="96" mass="10231" checksum="732B34CACF380BDD" modified="2019-05-08" version="1">MSRRNKSRLIVDLDDEVEFVTKVAKQTTRGVRYVDVPLPMPTGSNVPSPSKSPSKAPASGSLFNLDDGDVLGNIGVPIQLDPAARKTKVGTPAMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6H8</accession>
    <name>A0A401H6H8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1800690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE90047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620960.1">
        <property type="nucleotide sequence ID" value="XM_027765159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6H8"/>
    <dbReference type="GeneID" id="38786964"/>
    <dbReference type="InParanoid" id="A0A401H6H8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE90047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="133" mass="14663" checksum="B5FF28C690BE1371" modified="2019-05-08" version="1">MALCFTPLFELMSLPTGSSRLHHKPVVSSATIVDPPNLTCVIMTIWGLGFFFCDPWRDANVQMRPGRWEGEIGRWRWGGAGSRRSIRPGSGPWALSDRVMGACGSTRSGGVFVERLQVRRSAWEVGVGVLQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H718</accession>
    <name>A0A401H718_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1900740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000019">
        <property type="protein sequence ID" value="GBE90225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027621138.1">
        <property type="nucleotide sequence ID" value="XM_027765337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H718"/>
    <dbReference type="GeneID" id="38787142"/>
    <dbReference type="InParanoid" id="A0A401H718"/>
    <dbReference type="OrthoDB" id="3246367at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE90225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="315" mass="35572" checksum="B2B887E39FF1C891" modified="2019-05-08" version="1">MVFADPPGSSNYIYAEVPVGMLNDEIVDVAFVNLVDWYHFPGGLLALVRAHRFYDGGVSLGEHWKHKYLVDIDGMGYSGRFLSFMESDSAVMKFTVHREFLSDWIQPWYVLENNSTRCCPKPFPYPMLHYIPVSQSYQKIYNIHAFFSGATPSTLKIATLTASDLLPDQRCTMDGDRRLGRIAGAGKQWKQTIGRRVDMDDCFPLQRLNYLQLTTNIMVPTMIDPAVVYLSEEGYDALDRGQRSTSGSRRQKVTTSRESYGLVGGHLSKFFASHDRQLAIASDWFTPAAQGFWLYGFSTFYNVETGLDIQALGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5B1</accession>
    <name>A0A401G5B1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0102170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608257.1">
        <property type="nucleotide sequence ID" value="XM_027752456.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G5B1"/>
    <dbReference type="GeneID" id="38774261"/>
    <dbReference type="InParanoid" id="A0A401G5B1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1104"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="13">
        <location>
            <begin position="391"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1182"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1333"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1187"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1213"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1254"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1333"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1403"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1433"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE77344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1443" mass="160495" checksum="ABD997D90CE9297D" modified="2019-05-08" version="1">MDHRGQRPPRSARPPHSTSPPVDLDHPNVPYRPPLIQDAGRGISFQDRERGDRSEPLDETRQRSYTAYQNTSPSMLDPSAAESGLADGRVGRKKSLVKPDREKIDPGHRQWHYRHHAAEMQDQGGGKTVPSTTGNVPMKQQMRRGRSILGREEDQQESGLALFKRGTLRKKEVATPLATKDTPSRSCLDGLGPGPKNAWFIYCYVLTCLVPPFLLRVCGIRTPEQQRAWREKMGLIGIIVCLMAVVGFITFGFTETVCGTPANSFVAGTVENASVIIHGYDYDFSKFNHPAVGDFNGHTNPLLVGNWSVGGADISFMFQNTNGACQSFITKAANSTITGSTNNLEWYFPCNVYNQYGTSGVNLTNYGTNTTCHTSSAARQQLASMKPLGRVSYTWGNVSNPNRNLAVYDTSIFNLDLLQWLSPAYVNYPSVFDEMKHANGTFNGKDLSMYFLRTNQKELANCLKETITVGFIDTETIGCVASQVVLYVSLVFIIGVVSIRFGIAVFFAWFFSWKIGNFGEETYEQRRKRALEIENWTDNIYRPAPSQYRPNVYKNGVAKGGKRNNFLPSHSRFTPAENMIKGPGVNGRQSTAYGMLEPIPYKRSATASVYGSSSARSVSKLIPPDTPAYRQSRTSLIDGTRSLFADNQCPFPLHNVVPQPPPDYEPFNYPLAHTICLVTAYSESVEGLRTTLDSLATTDYPNSHKIILIIADGNVKGAGNTMTTPEICLTMMKECIVPPNEVEPHSYVAIADGHKRHNMAKVYAGYYDYDDATVERSKQQRVPVVLVAKCGNPLEANDAKPGNRGKRDSQIVLMGFLQKVMFDERMTTFEYEFFNSIWRVTGISPDRYELVLCVDADTKVFPDSLSRMVSCMVHDYEIMGLCGETKIANKAETWVTMMQVFEYYISHHMTKAFESMFGGVTCLPGCFSMYRIKAPKGDSGYWIPILANPDIVEHYSENVVDTLHKKNLLLLGEDRYLTTLLLKTFPKRKNIFCPQAVCKTIVPDTFKVLLSQRRRWINSTVHNLAELVLVRDLCGTFCFSMQFVVGMELVGTLVLPAAISFTIYLIIESIIPGGPNTTIPLILLAIVLGLPGVLIVITTFKITYVGWMIVYLLTLPIWNGVLPAYAFWHFDDFSWGQTRQISGGSKKDTGHGDKEGEFDSSHIVMKRWAEFERERRWKSGTQSRDSTVFDHRSYSPKRSDDRHSLVSVPDGQTYPQQFDESTYESSNNGYPRPRYDSNQLLMLPAPLSVNNRPVGSTSASVSTSGLSRSSEEGNASDIGSQQRLVSSAQDYHEGYDNTPYSPQPAPYQGAGFEEKVSRTAGAHSGVLRQATVSNQYPGETYNPYFQQPPTGYEDTPIPFTTDPDDMPILPTPASPARTRQRGISLADNGPVPGPGGVRRVARQSNAKRASSQAPPQNRYSRSSSSPHTNLPPGAAPPQPGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5E2</accession>
    <name>A0A401G5E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0102510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608291.1">
        <property type="nucleotide sequence ID" value="XM_027752490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5E2"/>
    <dbReference type="STRING" id="139825.A0A401G5E2"/>
    <dbReference type="GeneID" id="38774295"/>
    <dbReference type="InParanoid" id="A0A401G5E2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019385283" evidence="2">
        <location>
            <begin position="22"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="507" mass="55340" checksum="881FAEB86CACB4C9" modified="2019-05-08" version="1">MRSSTVLAVVTVVATPVLVGAVPTPADGSEALSFGDGLKIGKDVLGIFHSSSNNKNQQHSRDYDELLARNFEDIMARAEPAPTHAAVHEHVHQHAHKHHAHKHQKSHKHYHGHKHAPGHAHHAEQNAEHAAAYPSSKHAVIPPAHVAREPSYSMPKGQNSFGHAGEHVGVKSHHRDVEVREPHYPSFQGYKGGQHGGYVRELEDREFDDIFARAEAASARPNAHATAYTHEHVKGHAYNGHKHYKGYKHGAQENVQADPVAALPSHASAQPIHTSVHAARGSTLGSPGHSSAGGPKKPHRSIDEILAREDGNEAHSWRPSAQPIHTSVHTARGSTLGSPGHSSAGGPKKPHRSIDEILAREDGNEAHSWRPSAQPIHTSVHTARGSTLGSPGHSSAGGPKKPHRSIDEILAREDGNEVHSWRPTLDSAHFVRGLFYDGRNDLKQSRVYDELIAREFDDVMAREDDEIMAREDDDHMAPSLNTRLEILKKNGGRTDIFARNMALAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5J0</accession>
    <name>A0A401G5J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0103040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608342.1">
        <property type="nucleotide sequence ID" value="XM_027752541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5J0"/>
    <dbReference type="STRING" id="139825.A0A401G5J0"/>
    <dbReference type="GeneID" id="38774346"/>
    <dbReference type="InParanoid" id="A0A401G5J0"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="550" mass="62634" checksum="245EAFE38F74BDBB" modified="2019-05-08" version="1">MFTLREIFRFVQTLAVPVIFGLFVKYLVPKSDDNTLPPSLYLPILADIGFVPRSFPVTYRLDGYDFKHYERIQNVSFSVPDTTAVILNWSRFPNVLLITSLLCGDWLGDVIVEVSIWNNNPRQLTYEDFKNTGCPKDRLRIYNAPANMYFQGRFMGCAQARTPYCFVQDDDYLVRSEIVHALHKRMRSSSGSYGIYLTPPREHLTSTLREIRVSKPESSYLSDIHASFTWLGYGAIIHRSDAIDFISLLRRIRASDDEMKMADNFFTILSNRVPEIWFDREFELGGGQPFTIGPEGDERNNRYIQKATQYLESITHCNAPSCTSAVDAKPARAKLPYTSFQAYLPPPTWQRAACRGSSCVLETNIHLLPDTIGHTGDSIQNMLYLEKHNLELLGEAAKQHYIDYAPSNAVDTLTDTSFRSPGSAKKGDIISIDLLADVSEAYEWTIVEMAWLVDSATEAILDACTFESSMDQLVWHHASQRPICNDTDLRLPSDNLTSEDTPTYLRECSVQMLVASDALHLRATGRYFRVRLEEDQPEGWAVFEIWLRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G667</accession>
    <name>A0A401G667_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0105410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608573.1">
        <property type="nucleotide sequence ID" value="XM_027752772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G667"/>
    <dbReference type="GeneID" id="38774577"/>
    <dbReference type="InParanoid" id="A0A401G667"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328">
        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="243" mass="27105" checksum="84606D4A20955CA8" modified="2019-05-08" version="1">MSSSQLHPLRVNPGTGEPFLRLPSPLEDIIITPPRVTDAPSIVAILNDPTVCQWLKGPPYPYLPSHADSWLNDAKRESDATLLELKQTCREDSDGTLKLVGSCPVRSLRAVQEDGTDVYIGNVDFRRCAFLEEDPAVRGRLSEENTQRVVGDPAIVWCLGDYLAPSHHGRGIMTAAVGTLLASWAIPRMGVRRMRVEIFRGNNGSVRVFEKNGFVLEKTLDQEKVTNYGNTIYGHNILWWEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6G0</accession>
    <name>A0A401G6G0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0106210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608652.1">
        <property type="nucleotide sequence ID" value="XM_027752851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6G0"/>
    <dbReference type="STRING" id="139825.A0A401G6G0"/>
    <dbReference type="GeneID" id="38774656"/>
    <dbReference type="InParanoid" id="A0A401G6G0"/>
    <dbReference type="OrthoDB" id="2757691at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="473" mass="51745" checksum="A2A6333FDB8F9311" modified="2019-05-08" version="1">MPSQGPPPSVGGKDLSSFLPDESGSGGGTASLPNPAQMALFQENRERQARNAARAVRRQGGEDGVSDDEELGMLDGSDGTSPGQLDSQEPSATPAGMPSRPRTPESNTDDMQLLRDVMKMTPNTRGIALKLWNAGVEKWSGAGTRTEASVGNGGKSSENALITIDSESKADLFAGRVIEMPQELPALLRNEFHLPLSMCTSEVMTKMHKHPEQVQYRKMHDGKGIKRALIDIAQWPDEQAMGPEEWRDAWRNYFEILPGVCDGEIVKRFSEHHMWLSEQSDFKRIFPVILAFDIDVRRGYFLTKKTFVVGSKSYNDHFLKIRLEHIEKGSRCALPIPAGPIVGSSQTPYRTPSHSPDSRRPRRDGAADSTAKPFREGRASASTSMLCLICGESGHRASQCGRSTMSNGKPAFTVWENKKLLAISTRVEICLTWNVQHGRMPCRGMYCPGTGGHVCSFCGSDGHAAATKRCLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6J0</accession>
    <name>A0A401G6J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0106510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608682.1">
        <property type="nucleotide sequence ID" value="XM_027752881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6J0"/>
    <dbReference type="STRING" id="139825.A0A401G6J0"/>
    <dbReference type="GeneID" id="38774686"/>
    <dbReference type="InParanoid" id="A0A401G6J0"/>
    <dbReference type="OrthoDB" id="3355480at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="556" mass="62538" checksum="42FD8FB488A4CACD" modified="2019-05-08" version="1">MSAIPTPPPLEGEKYTFMPEEVTASLVDNMHPSKVTQLQRKMGDTELSYYLPSRQTGVNDMYLHLGFHAPARLTRRARVRAVWGILRLRHPLLAAQVQMHDYDDVRFIYSAPSSPDDVLADADATLEYRMQDKDELIDTYLNGPRTLSNTRLSYLILSEPAYSTIPTPPRTPSPSRTTTTSGPSEQQGERANQYDLLICAMHFLGDGMALHQFANDFFGLLGSEKSDGELEEALTEEWRTRWENVAHDASILPQALEHNMPLSPSRFRRAAAKVDFQMSQQKLVGGQAFPRQKHAERQTVVPTLAFPEDRSKAMLKKCKANGVSISAALFALCNVAWARMGGGERALPVLMYAALNLRPYFTVKRPTLWDSYWYLAIGYFDVVLPNFLPADQNRVEAIFWHRARQAKDQSTHAAKTPLVPSRTHEMARERGERACGWAREDDEKEKGTWVPPAPAAPSAPREPVLPARVEAPSAALIGLSLLGNLDGIYKHATFPNIELHTLTTGSRQRHGAMLLFGYTFKGKLWVSLGYDRNGFKGDVVDRFWTELLKGIDEFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6M3</accession>
    <name>A0A401G6M3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0107030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608734.1">
        <property type="nucleotide sequence ID" value="XM_027752933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6M3"/>
    <dbReference type="GeneID" id="38774738"/>
    <dbReference type="InParanoid" id="A0A401G6M3"/>
    <dbReference type="OrthoDB" id="3205299at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="205" mass="23252" checksum="9B9DF207D3967B69" modified="2019-05-08" version="1">MRRQRPATPATRIYHDIVVQWSYQSREEDPFSLTDFFPQANLPDSTKGDEWLWLQYETSGRGSVLSGSRLSSPISEEDEEDLPPPRAEEEDRTREITSHEDQIVVLALDSKPMLPEDDGPTSDDRLLSPYPEEDSPDDDEALYNVLSALRRSYSRPHSPGAGDEATTLNRLFSEKGEDADDLELGEGLVHRGMCRVFDLLDVDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6U6</accession>
    <name>A0A401G6U6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0107510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608782.1">
        <property type="nucleotide sequence ID" value="XM_027752981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6U6"/>
    <dbReference type="FunCoup" id="A0A401G6U6">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G6U6"/>
    <dbReference type="GeneID" id="38774786"/>
    <dbReference type="InParanoid" id="A0A401G6U6"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="116"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE77869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="205" mass="23344" checksum="17ECA2A77A5F20B6" modified="2019-05-08" version="1">MGTSQSLPKITAQDKAILDLKLQRDKVRQYQKKIQAVLEREYEIAKQHLAAGNKDRALFALRKRKYQETLLLKTDGQLENLESLVSTIEFSLIQVSVLHGLQQGNEVLKKIHEEMNVETVEKLLEETQEAREYQREIDEMLANNLTVEDEEAVQTELRELQREAIGKPDMLPELPSAPTAEPVAAPPAEEASRVPQKRERIPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8C4</accession>
    <name>A0A401G8C4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">chitin deacetylase</fullName>
            <ecNumber evidence="20">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">SCP_0112890</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polysaccharide deacetylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="20"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609315.1">
        <property type="nucleotide sequence ID" value="XM_027753514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8C4"/>
    <dbReference type="STRING" id="139825.A0A401G8C4"/>
    <dbReference type="GeneID" id="38775319"/>
    <dbReference type="InParanoid" id="A0A401G8C4"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.370:FF:000004">
        <property type="entry name" value="Related to Chitin deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="18" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019546543" description="chitin deacetylase" evidence="23">
        <location>
            <begin position="18"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="24">
        <location>
            <begin position="213"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="GBE78402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="504" mass="52867" checksum="2450A6C8543EDE90" modified="2019-05-08" version="1">MKFAVLSALAIPVVVSAHGVNVVRHHPRQAAPVAAASSALPVASSGSSVTSAPAPSSSGSGAVASSASGTVSSRFVSGATTLSFSMASENPTAVPLSDITYSMSSWPTAPLFSTFAPAATNSLISNAPPLPNAALIVPSQYPALDKTPPTDSPQVQQWLSEVMNSGIPIPDLSPTNPGGCGNNSAILGEADRCWWTCGGCTTTTDITTCPTKFNWGLTHDDGPGPYTPGLLQYLEMVNLRTTFFVIGSRVIEYPVTLQTEYMSGHQLCVHTWSHPYMTTLTTEQVVAELGWAKAIIKAIIGVTPLCWRPPYADVDNRVRAIAKALNLETIIWTGVNVGQSNHFTFDTNDWDLPAGLVTPWQVLDNWNNIMGNVSQLDTGFIVLEHDLFQQTVDMSTGYILPDALAHQPQLNITPIHECLGRTLSDVYLETNNNASNPIYVSSYGTSSYSGTAAAQSTSSGGSSKSGQGASGASNTNGATSSMAHYSVVGMSLVSLLAGIGAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8Z4</accession>
    <name>A0A401G8Z4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0115210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609545.1">
        <property type="nucleotide sequence ID" value="XM_027753744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8Z4"/>
    <dbReference type="FunCoup" id="A0A401G8Z4">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G8Z4"/>
    <dbReference type="GeneID" id="38775549"/>
    <dbReference type="InParanoid" id="A0A401G8Z4"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="257"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE78632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="557" mass="60802" checksum="5AB21BAEA0D3BEB5" modified="2019-05-08" version="1">MTESTEAAQNEAEAPDSSDKPPHPTKQQRVNGTKHNRSPSKAHAAIAVAVAAVHDIATLMPNGHVPIPPPDSHSFFKSPGHTRRSLEDLHKLEKLTLDAPPPLKRDSSSTTGSMTPSSESPSVSECESWSVPSTQPPSRAPSMSSGVSGNKLVSLPKPTKPAKTKDHSPPSTALWISPTPSGGEPQSPTTARAKSPPSVHSETGGQKFTLKDLLGAPKLARKSSARSTGSSRKSDSDNEGRSTTGKSTASLLRKYGVCEKVAIGKGATSVVRLAHKWDRSEEKLYAVKEFRKRRKNETEKEYVKKLTAEFCISSTLHHVNIVETVDLVQDENQHWCEVMEFCPGGDLYAAIKRGGMSPSEVECCFKQMLTGVAYLHSQGVAHRDIKPENLFFDTRGHLKIGDYGASTVYRLPWESTVHMSTGLCGSEPYIAPEQFLGKPYDARLVDVWACGVVYYCLHFQELPWTVAQPTDHLFAAYASACQTVNGCPPTINNLSPRACRPVIRKMLEPDPKRRALIDELIAHPWVQGIEVCHTMARPTHVHVNATIMAQAQVQIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9F9</accession>
    <name>A0A401G9F9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0116660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609686.1">
        <property type="nucleotide sequence ID" value="XM_027753885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9F9"/>
    <dbReference type="STRING" id="139825.A0A401G9F9"/>
    <dbReference type="GeneID" id="38775690"/>
    <dbReference type="InParanoid" id="A0A401G9F9"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="287" mass="29963" checksum="8E2F9F1EF9B115D4" modified="2019-05-08" version="1">MAAYVAPVVPSTAVFKDGLFDGKVLFCTGGGSGICKAMTEAVMRHGANATIVGRKLDRLTASAAELAKATGRECLPAQADVRDPKQVHDAVAKTIAKFGRIDYVICGAAGNFLAPISGLSENGFKTVVEIDTFGTYNTIKATLPHVRASKGSYIHVSATLHYRGTPYQIHVSAAKAAVDAMSAVLAVEEGPHGVRSNVIAPGAIANTEGASRLMVKNTEYAAPAGRIGDVLDVANATIFLFSGAAAFISGQIIVVDGGYEHVRSSWVPYPQSVLDPASFQASMKPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9I0</accession>
    <name>A0A401G9I0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609731.1">
        <property type="nucleotide sequence ID" value="XM_027753930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9I0"/>
    <dbReference type="GeneID" id="38775735"/>
    <dbReference type="InParanoid" id="A0A401G9I0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="119" mass="13070" checksum="AD69D2E4C84E6082" modified="2019-05-08" version="1">MSVSQYVSFVSIPSAEVPVTSQQDADTVARIMECTHGAASNDASSLLHILFNTLKNFWSRPGVQFARLFEVCLQSEACARPRSTHPVSRILGHRGQWIQGGDRPPSALRTARPRSSFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9I2</accession>
    <name>A0A401G9I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0200270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609743.1">
        <property type="nucleotide sequence ID" value="XM_027753942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9I2"/>
    <dbReference type="GeneID" id="38775747"/>
    <dbReference type="InParanoid" id="A0A401G9I2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE78830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="31517" checksum="991209FC0DFD9E13" modified="2019-05-08" version="1">MPNTTNWVINELGAGPLDLMDSAALAAISGVWGHIDGVPLQPNQGSHLGDASDTGNMVSGAHEPGPHIATSPTDIANLGMLSVVQDRPIVLPATSDMASSSMFRFPVPPPAYVIPMHALTAAAINTSSRTSSDAVSVPADIVQSGIDASAERDALRHSEVHSAPVIQPVLASAMPTIVQPADHVAPVHSINTFSPPSVDLDGTATSTAPSKTSASTSCSSSPIDLDGTATSAAPSASNSCSSLAQPSRTRKLPPTADSIWEPTAAQARRLGISTMESDSAKPKRKSAKENKAEMGEGNDGVKRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9T7</accession>
    <name>A0A401G9T7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0201140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609830.1">
        <property type="nucleotide sequence ID" value="XM_027754029.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9T7"/>
    <dbReference type="GeneID" id="38775834"/>
    <dbReference type="InParanoid" id="A0A401G9T7"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="12">
        <location>
            <begin position="1336"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="538"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="582"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="759"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="893"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="928"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE78917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1545" mass="166877" checksum="25D4B94FD90085C6" modified="2019-05-08" version="1">MATKAHALSYDSTGSSVLAQFPLPISLASPVLTSVISLADRPLIAYSVFIPPPSTNSSDHLNCIELARRTIISRNGQSTVLDSLLPSVYIAKDICRLYVFAFSYSDNISASHTALAALQFDALILTESATFTPSTIYPCSVACSEHAIPCPDCLDHSQTAKTPAQLFPRNSLRTPVHQFLQAVRERLIDDIAAASNSGRPAMRLKDGFLLGPTSASSEWGAGWDQPARMRPLIYCHILVHLSQMPARLTIHPILRPTYYVPLCSSLPLPSGTPISLLPHGVPGYYLSSYAGPTAALTSQFDEALIGLGAGNWKYTPSSNIGTSAKKDFPVYIIAWISVQNKQGEDKGMPVIWPVRLCLAYHSSSPSPHARMPLQQTPELPAQLQASPPPPAAPIPSGGPSSSSFLSSSDAKTRSSTPHPLLSTLRHPPTLISSPSSDAVRAFSTLTFTTKPHVRDFRQVAAEVSNYVDAVAKERERERERIKREREIGSTRTRAGSTSTAGAVPSVPPSSVPPAPRSPKVEEAPTPAIAVAPQPPADEAMVDQETEPAISSEDSLESLFSPPPSASDLPESDDAIQFAAQAVTDTTSSVPEEPVPSVTPRQETEPSATSSFDPFGTFDATWSQPSNGFLEMNIDNIDYDMGFSGMNIDSIGGERNGDEAAGDFDKDDGFGIFTDDDFDFFDTPAANARSVGTVPVTSAMDMGMGHTVAAGPAPLGLPPLGLPPPLAGDGILFSGPGPPAAVSNQSSPWVVGSPIEGFTPRGSDFHRRGDYISAPPDLVPPTPTRTPSTQSAPVTPSVQLSDQDDPRQYEGCGPSVFDPIPFALSHRLADGKYAIGKFALPSPPDEEDRTEPIVFASVPSWASGWKLKYTEATDPRIGIVRKLIGVKRKSFDQGMRDGKMSPSWVTEHEEWESSSPSPDVEMADATSDVSEDEEPWVEEDDAMTARPSTPPPSYLPMGPVLLQTQFHHSHLLPLCSPLRPSGAAVNNLTASTPPMSVPTPVSPAAVLGAASEKSKSLEAAAQLLMKEAVENSAWADAWQLNAVASVASASPPTQVWQADVKYVSWLLGSISSAQSSVNVEQLVVPHCKTEHHSQVLLRLLEPPMFAVGKSDSVVQVLPTAVRFWEKLGLGPRSGKKDVIVYVFFEGGGDERESEIAQWLDIVSAAYSAKNYGKHAAGNSDSCTRAGLVPVRLDAVKKMLVNFVATLPLSALSSSLVFYFIVPPAMISLSSQPLRHLFSAMKRTTKTHIDAQILFHFVPEPLTTAIHSDPCTSRAELEHFVDSVYDRVLQPIERMMSRKLFTHGTRTRAYFHAPAFSLVRSRPSTRPSLVGELGHAAHVTFALEPHPLSLDVVDRYTLLHVGYRITPCGRWLLAACIDARGEEHELGAWLLPGEAVETYVVNQVWAFVHTFSIRANVEWRIVVAKMGAMSSTELNAWTTQLDIATSVSTEHPALHVTLLSIEHELPWTFLGPTSNDSMKRIMSPSPTTSTRVSARIPSAQRVFLSRVVYPPRNTSLVPPMHLSSQIVKTMSHHYNIIPVCWLGESVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9Y0</accession>
    <name>A0A401G9Y0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">SCP_0201580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9Y0"/>
    <dbReference type="FunCoup" id="A0A401G9Y0">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G9Y0"/>
    <dbReference type="InParanoid" id="A0A401G9Y0"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE78961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="20484" checksum="7FA90C497D5EECF2" modified="2019-05-08" version="1">MVRGSNSAPAQLCAPDSPRSSESPPPSGVQGDLELELMGLANALYNLGTTVINDLTKEKDKPGGGKQVGHRVNDVIHYLATIDDMSQHVHTMVPMQVLADVDNSRNPMALTKERLERVATENQFMNGKIHAIDSYKKYLDEALIQNFPELSEYLLESSSQSHQEPEQASNAPTALSMPGEAMINGVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAF1</accession>
    <name>A0A401GAF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transformer-2 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0203280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610044.1">
        <property type="nucleotide sequence ID" value="XM_027754243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAF1"/>
    <dbReference type="FunCoup" id="A0A401GAF1">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GAF1"/>
    <dbReference type="GeneID" id="38776048"/>
    <dbReference type="InParanoid" id="A0A401GAF1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE79131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="279" mass="32053" checksum="1DD84C794FA0481B" modified="2019-05-08" version="1">MYGDNVAPPVDPYSDAYNDAPPAAPAPAVDPRDRDLPPPRGRSRSRSPVRGAGPPSSFRRSPAPRRPAHAPIAPNPSNVLGVFGLSIRTTERDLDDEFSRFGRVEKVVIVYDQRSDRSRGFGFITMSTVDEASRCIKELNGVDLNGRRIRVDYSVTDRPHAPTPGEYMGHRRRRGRDAYPSRDFRDDRYDDYRDPVRDSRRDRDPYARRDDRDRDNYGRDSRDWRDRRSPPPRSRYSPDYRRRRSYSRSPPKGSSPTRVRDYDASSSALPPTNGDTSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAM7</accession>
    <name>A0A401GAM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein YIL156W-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610131.1">
        <property type="nucleotide sequence ID" value="XM_027754330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAM7"/>
    <dbReference type="STRING" id="139825.A0A401GAM7"/>
    <dbReference type="GeneID" id="38776135"/>
    <dbReference type="InParanoid" id="A0A401GAM7"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018990420" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="72" mass="8078" checksum="1686ABF977C41DD5" modified="2019-05-08" version="1">MFGTLIHLGCDALLVSAFLAGIRRTTGLTPKLTEVPNKDIRQILRSYLEIGEYIFDFAVVLCGRSSSFERRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAV5</accession>
    <name>A0A401GAV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610205.1">
        <property type="nucleotide sequence ID" value="XM_027754404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAV5"/>
    <dbReference type="STRING" id="139825.A0A401GAV5"/>
    <dbReference type="GeneID" id="38776209"/>
    <dbReference type="InParanoid" id="A0A401GAV5"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN / WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232:SF1">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN _ WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="93235" checksum="7E111D0993738A56" modified="2019-05-08" version="1">MASSEKRSASPVEPFNPKKARTSLLTSKYKTSPTPESEPARAVITRGTEWLSISGLDRDTSSINTLIVRTTQELARQGKRLVHAPKLFPDGICFDWLLDFSAKEEDVKDLMNVEGVSQPALQTLFQGKPRGVRSTRCGSRGSPTEAPLIIHLLSDDESESPMLASRRVPQGGLDASNPICIDTDDEQDPPVSPPTKYPVTDGTMSRLNKNGSSIRGSSRRQALDDEGRTGIVSRLLLPEVEPESSSECGQSDMELDSDTEPSASIRANGSGQSLVFEPRTASPEHRKMSRIPAARRSSNSAPLCQPSHSMTVHRSSTPGSSASIESSRSSSVVPEVDVVLTTVSSRHSTDHPDVSSLYGEFNMLATSSDNDVDDDEDVQEDPASGSSSSGRGAPRSAPSTGTSEQALLHHPPHRAPARSSLSRSWSGGHARSIAKDPSIDTHRSASIAKLPRRAVPARNRLAHPNKGLSLSSDDEGDGGENLLEGFESDRLSLPSRKDPHVGRATGWEDTGSNGLSVNIPKTNFARGRRLLAPSDLLPYTTVAMRGDAQFIRKDQLISYYSLPPSLDPSGGPDHHVEDCCLIAGNTVVVGYDSRPCQVSLIPLATDQRPRRINLSHRAHNTVQETPTAGVSQLNRGISALAPVNGHRLRFLSGGHDKTVHLWTVTHNGENYTARSERLNISHSHPVHALAYRAFDETVLSCAGTCIHTTKLSAHRGHDPSQVSGNILQVHVHPQAPHLIILEVRHMDRQVQLYDTRKANFARTPCLEFGYRDTSNLESSTRTTTSRYTKGAPCMSFFGRGYADGTVRIWDYRKPNNVLTRFHCQRPAPVVHTVFSDSGSTVIAYGGHSVTFWDVNGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBL1</accession>
    <name>A0A401GBL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0207490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610462.1">
        <property type="nucleotide sequence ID" value="XM_027754661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBL1"/>
    <dbReference type="FunCoup" id="A0A401GBL1">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBL1"/>
    <dbReference type="GeneID" id="38776466"/>
    <dbReference type="InParanoid" id="A0A401GBL1"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="297"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="8">
        <location>
            <begin position="500"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="711" mass="77386" checksum="4B1DF507298C288B" modified="2019-05-08" version="1">MPPKRKATSSAAPDLAVPAKRKLRKTHELPVIPSPTLRRSTRGHPHAPIAPPQTVESRERSPLPRPHRARGLVADALAESDADDADDADELLLTPSRKLPARPVTPTRVFTPRGAARRLLFEAVEIVTPRRLSRLPTKDNASPAPSLSRAQAQRLQREPHAAIPAAPHTPTRRASPSPSSPSKRRTNQTLYGSPEAVISQAKLLVHPESSPHSRTTCPRKVDTSSTASASTTPKQKAAAASHASLSRLPHILPAYLHASLDRQKRSILESLQTLPHVEVEDAAVDEDGPSTTQIAYEQLSDLLKGTALRGEGNSCLVIGPRGSGKTRLVELAISSLPDMPIVICLSGYAQHNDRLAIREIARQLASQTGNSLLPADAEKDADEDPENPFIDTADTTITLPPPAHLLALISVIPTLSRPTVIIIDAFDLFATHARQSLLYCLLDTVQSCRASKANKGVAVIGVTTRVDTINLLEKRVKSRFSGRMLRTACPSRVSYWMALAQAVLCAPVEIDVNGQWPSLWAQCVHTFLSDETVIRIFEETFALTRDVHILRRILVNSVLELTPATPHLSPSKLAASVAIQRCPSRFPFLSSLPYPAICLLIASVHAPTSGHDTFTFEMLHECFRDHVRTSQSAPVQVEGGGIGMVRCSREVLMGAFERLVSLRVLIAVSAPSAGTAKQFVMYRSALDRVDVKRAVETMGQTNLKKWFSKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBN8</accession>
    <name>A0A401GBN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0208060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610519.1">
        <property type="nucleotide sequence ID" value="XM_027754718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBN8"/>
    <dbReference type="GeneID" id="38776523"/>
    <dbReference type="InParanoid" id="A0A401GBN8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE79606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="196" mass="21839" checksum="DD1367E9EBADB0DE" modified="2019-05-08" version="1">MDASVILRKYTLAEALLRIEIFTEPFDPILWKAWAVRMHVLLVLMVQAQSEAASVGIILPLLCDIPVLAQVEIHLATARTVEGGYRMIPRIVDHLPAVIPHGLTARVLYDDPAVREDFGLGHPPDGLSDIGTLRLRVETLRNAARELYDVMRGITGRRELADGTLRRLRITVEELEVAFGLVVCPPLITSFQLMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBY4</accession>
    <name>A0A401GBY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Probable extracellular serine</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0208650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610578.1">
        <property type="nucleotide sequence ID" value="XM_027754777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBY4"/>
    <dbReference type="GeneID" id="38776582"/>
    <dbReference type="InParanoid" id="A0A401GBY4"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019303033" evidence="6">
        <location>
            <begin position="21"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE79665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="524" mass="58079" checksum="C7D41FE3670ACCCB" modified="2019-05-08" version="1">MSALRMLAPLLLLLASVANGLLRDGKLRANTAHPPGVPKVFPRSVNGPVTSRNGTQLPPYDTVYYFDQLIDHTNPSLGTFSQRYWFTYEFYEPGGPIILLTPGEINADGYESYLTNDTMNGLIAEQQNGATIVLEHRFYGYSNPYQNLSVQSLQVHTIQQAIDDLVYFASNADLPMPGGDHVTPTEAPWILIGGSYSGALTSFTVANQPGVFRAAYASSAVVESIVDYWGYFEPIRQYMPQNCSADVEAVIAYLDTVFTTGTTEEQDAMKTLFNMSLSHPDDFTGALRNNLWDWQSLQPYVGPGAQFFEFCDALEVKDGVNAPAQGWGLEHALNAWGTYWADTYYYLICGDYDAETCLGSYDPTQSYYTDIEINDSGRSWEWIVCNYIGFLLDGAPTGWPSLVSRLIQPIYDERQCTYFFPEQFPVATAPNVDATNAAYDGWFVNVDRLFFANGQRDPWREATVSADGTNFKSTQSQRIAVGDGFHCSDLLTASGQVDATIAAVQKQVLAAMAEWLVGYEPSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDM0</accession>
    <name>A0A401GDM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0214350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611138.1">
        <property type="nucleotide sequence ID" value="XM_027755337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDM0"/>
    <dbReference type="STRING" id="139825.A0A401GDM0"/>
    <dbReference type="GeneID" id="38777142"/>
    <dbReference type="InParanoid" id="A0A401GDM0"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE80225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="289" mass="30833" checksum="1F0D7AE7AECA1513" modified="2019-05-08" version="1">MEQVNKVWLITGTSSGFGKRLVASVLARGDRVIATVRNLKNAPIPLDSQRSRLHVLVLDVASSADKIQRTVEAALAVWGRIDVLVNNAGTGAKGMLEEVSPSTALAQFQTNVFGVMNVTNAILPHMRSRRSGTVVIIGSRSVWKTGPTVGMYVASKAAVHALGETYAAELRPLGVRVMVVAPGAFRTENIHSAPIMAERRIPAYDGTRAAMQAVFRDVAVNAPGDPAKAMELLVDVVKGEGAARGHEMPLYLMLGGVTFSDVRVHQKKVSACLDGWEGVASDLNFDAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDX2</accession>
    <name>A0A401GDX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611301.1">
        <property type="nucleotide sequence ID" value="XM_027755500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDX2"/>
    <dbReference type="STRING" id="139825.A0A401GDX2"/>
    <dbReference type="GeneID" id="38777305"/>
    <dbReference type="InParanoid" id="A0A401GDX2"/>
    <dbReference type="OrthoDB" id="2802569at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11943" checksum="B15FB0BE8B998821" modified="2019-05-08" version="1">MDVDRINISRLSPDEQQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMQEDLAQKKETPKEETREEQIAYVRNVFNDMTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDY2</accession>
    <name>A0A401GDY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611307.1">
        <property type="nucleotide sequence ID" value="XM_027755506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDY2"/>
    <dbReference type="STRING" id="139825.A0A401GDY2"/>
    <dbReference type="GeneID" id="38777311"/>
    <dbReference type="InParanoid" id="A0A401GDY2"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="389" mass="40333" checksum="133D0AE301413EE1" modified="2019-05-08" version="1">MCAGLVLEGKPLPTSPPPYDVKVDSNEPDGAEPMVMGASKRKPPKKTKTRNAAASSSKVKGGEEVEATKQKATAMPYEANAEGEASVEKSSKSKCATESATATGAVALSNSGEVANSGEVTNSGEVSKSGAPAKSGAVAKPGKGKKSGPKPKLVRSQNSGVQDGGEVTRTSVREADEVPPAKSVAKEGGQMTRVAMGGCSGPMVLVITRKAKVNARKAAAKAPLVEGDGMEEAARLAMEAVQARAFQTGPAAPLQASSSKRMLTPVADKPEDVPEFRAEVAEDQRTSLEWPHDDRQHSLLTRHEMSAGAAEVAQEVTPSLEVSKASKGVKSSASAKAGHVDGGRRPAKKGTTLDHKAVKKEAEAKRDTKANRLRAVPPTSKAPHLRDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE45</accession>
    <name>A0A401GE45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0301100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611308.1">
        <property type="nucleotide sequence ID" value="XM_027755507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE45"/>
    <dbReference type="STRING" id="139825.A0A401GE45"/>
    <dbReference type="GeneID" id="38777312"/>
    <dbReference type="InParanoid" id="A0A401GE45"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="202" mass="22535" checksum="142EB71FA9606CED" modified="2019-05-08" version="1">MKATPPVEFLAHKDGMEVQFQERMADLNTVKAEITAVLQRMNPPSALQENARSIRKEAKLAMEEFRRPVTIELQESMKLAVVDLVAKRHCLPELKEKVNRLEQGANQTVSQADIEKLQGELADLRHSMELQAAWSDSMEKELRSSAAEAIAQVSKLEMELTLAKEDSMVVATSALDEAKKVMKEVATAREETSLVAKSLDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE55</accession>
    <name>A0A401GE55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0301620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611360.1">
        <property type="nucleotide sequence ID" value="XM_027755559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE55"/>
    <dbReference type="STRING" id="139825.A0A401GE55"/>
    <dbReference type="GeneID" id="38777364"/>
    <dbReference type="InParanoid" id="A0A401GE55"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE80447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="324" mass="35581" checksum="C5C93CE93328074A" modified="2019-05-08" version="1">MGSAFSALDAWLNFSNTLTVVRQSFPPKPTFSTDQIPDLTGQVIIVTGGNTGLGKEVITRLLEHNAKVYLAARSKEKADAAIKDLKELTGKEAIFLMLDLTSFASVRRAAAEFLGKEKELHVLFNNAGVMASPISFLTVEGYDMQFGTNVIGHYLFTKLLIPALVAGKDTSPDYHARIIHTSSSAAYLSTMDFDTFVPGPARLKLSPTSLYAQSKFANVVVSRQFAKRYADQGIVSIAVDPGNIRTDVLRNYGFFLQKLWDLLLSPVDLGALTQLYAGTMPEAVNHNGKFLIPYARVGVCRKEAYDDALGECLWNWLEEEVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE76</accession>
    <name>A0A401GE76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0301970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611395.1">
        <property type="nucleotide sequence ID" value="XM_027755594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE76"/>
    <dbReference type="GeneID" id="38777399"/>
    <dbReference type="InParanoid" id="A0A401GE76"/>
    <dbReference type="OrthoDB" id="3211582at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE80482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="182" mass="19738" checksum="B606E079B31D34D9" modified="2019-05-08" version="1">MGILRTNSFQVMWSGDTTPLTSTATAFVYTKMPFFPSSSAEGPTSATPDPSEEAPPSRSRSIFSRNSRSPDYQPSTAANSTRSGNGSSRGFFSQRRSSSSNSGQDLRNHPSIVGARQKVADAVAAERDVDQALRQARASVRAAREHVRLLEREAKDEARRAKAKQAELETVSKSAKNLGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFZ6</accession>
    <name>A0A401GFZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide lyase family 14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0308140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612002.1">
        <property type="nucleotide sequence ID" value="XM_027756201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFZ6"/>
    <dbReference type="GeneID" id="38778006"/>
    <dbReference type="InParanoid" id="A0A401GFZ6"/>
    <dbReference type="OrthoDB" id="2395160at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019118679" evidence="2">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="3">
        <location>
            <begin position="96"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE81089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="359" mass="37543" checksum="14D38907BA92134C" modified="2019-05-08" version="1">MFPLVLIISTLLCPSFVASTASPVVTPAAVAAKYSLSASTSLPFPTATLSSSDTQSYLSSSWPLQGGIDRGMYLAFVDDPFPTSSPSSSAGIPEPTGPVLQVTYPAGSYSNNTGGAQFYAAWGGSNGAPFNSMVLTYEVAFDSDFNWVMGGKLPGLRGGPDDDGCSGGSGANGSNCFTARLMWRTDGQGEVYSYFLPTSELCASPDFICNNDGYGTSIDRGSFSFVAGAWNRVTLYVGLNSLLNSSDGQVALYYNNTLALTETDLQYRNSSGINIGGLFFSTFFGGSTTAWATPQTVHTYFRDFQMWGSTAAASPVSSSPPASTSTGSKPSGASSVQVAWISLAGVLFVDVFFAGGLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG76</accession>
    <name>A0A401GG76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxisomal targeting signal receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0308950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612082.1">
        <property type="nucleotide sequence ID" value="XM_027756281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG76"/>
    <dbReference type="FunCoup" id="A0A401GG76">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GG76"/>
    <dbReference type="GeneID" id="38778086"/>
    <dbReference type="InParanoid" id="A0A401GG76"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF9">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE81169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="638" mass="70838" checksum="6BC80CD530D25618" modified="2019-05-08" version="1">MSLQGLISGSECAVPFNPLSQVLKHAEGDRSLQQDRIAGPSSSKLHHLPSTSSALGAERDLALARQFFDPRTQTPNPGASFNAQVNFTPSQVTRMDQEIAKGWSDVNSIQNVMFRQEIGKPTTSGWASEFSSTSRVSPGPQQEQSISQRPDIHQRPFMDSNMYGGSMSFGMYNPNMPFLQSNDNGKGKGREFDLEAAFAQLDASFATAQTEGARIVEVDDVVSEPSESTLPQDLQETDNTSVKHNTDFNSVWDELQKSRTPPAHEDIAKWEAEFNQLMSSHREDGDYDYGEFMQNAFHDGLVDEFGNRLGQDADTIKFDDKGLPILEPYVFEPNNKYLDPSIAPRSPLREAKALLEQNGSLSEVALLLEAAIQQGELGTGGYEAWILLGETRSMDEREEAAMRALTEGVRRAEQAGASGEGVMPLAIAFTNEGMERASHTMLLRWLQARFPSYEIPQDAWDSLSQSTWHSHERAKEVFLDIARDQYSQGEIDPDVQMGLGVLFYTTTDYTRAKDCFETALTVRPKDYLLWNRMGSSLSNGNEPEKALGAYREALQLRPTYTRAIYNVGVACVNIGAHTEAAEHFLSALAMQETSGGTKSEHLWLTLRRTFVSMGRPDLADKANSSTNVGIFRQEGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGY7</accession>
    <name>A0A401GGY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0311690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612353.1">
        <property type="nucleotide sequence ID" value="XM_027756552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGY7"/>
    <dbReference type="GeneID" id="38778357"/>
    <dbReference type="InParanoid" id="A0A401GGY7"/>
    <dbReference type="OrthoDB" id="2369050at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="59" mass="6838" checksum="D7D6DDB5AB71D3A6" modified="2019-05-08" version="1">MKVPILHPGNISPTVMCEYEHACRNYFEHKEISDDKHVRKILAGIKDSRICDWIASNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GGZ2</accession>
    <name>A0A401GGZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0311610</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612345.1">
        <property type="nucleotide sequence ID" value="XM_027756544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GGZ2"/>
    <dbReference type="FunCoup" id="A0A401GGZ2">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GGZ2"/>
    <dbReference type="GeneID" id="38778349"/>
    <dbReference type="InParanoid" id="A0A401GGZ2"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000176">
        <property type="entry name" value="Isoleucine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="21"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="698"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE81432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1083" mass="124192" checksum="B8D36719F50E3A86" modified="2019-05-08" version="1">MPLPPHDLTAPFNFAKEEEKVLEYWKEIDAFQTSLKLSEGRPEFSFYDGPPFATGLPHYGHLLAGTIKDIVTRHAHASGFHVSRRFGWDTHGLPVEHEIDKKLGITGRDDVMKMGIAAYNAECRAIVMRYASEWRRTVERMGRWIDFDNDYKTLNVTFMESVWWAFSELFKKGMVYRGLRVMPYSTGCLTPLSNFEAGLNYKDVSDPAVTVAFPLVDDRKTSLLAWTTTPWTLPSNLALCVHPDYTYIKIHDQARDENFILHEGLLRTLYKDPKKAKFKKLGTFKGSDMKGWRYVPLFEYFTEQFEDKAFRVLTDTYVTDADGTGIVHQAPAFGEEDHRIALANGVLRPDEMPPCPIDDEGRFTKEVPDFAGQHVKVADKDIQKVLKAKGRLIVQSTIQHSYPYCWRSGTPLLYRAIPAWFVKVSPIVDQLVDNNSQTRWVPQNVGDGRFANWLVNARDWNISRNRYWGTPMPLWASDDLEEIVCVGSVAELEKLSGVNGITDLHRDKIDHITIPSKQGKGQLKRIEEVFDCWFESGSMPYAQNHYPFENKELFEKTFPADFVSEGIDQTRGWFYTLLVLSTHLFGKAPWKNLIVYGLVLAADGKKMSKSLKNYPDPNDIINLYGADATRMFLVNSPIVRGDNLRFREEGVREVVSRVLLPWLNATRFFLGQVALLKKARGHEFKYSPHAAVSANVMDRWILARCQSLIKLVREEMAAYRLYTIIPRLLDLVDELTNWYIRFNRRRLKGEDGLEDTVAALNTLFETLFTLCRTMSSYTPFLTENIYQSLRQFIAEDPSAGDARSIHFLSFPEVKHEYFDADIERQVKRMQTVIELTRNIRERHNISLKTPLRELLVFHADQQWLEDAKGLQRYIQSELNVRDIIFTSDEALAGVRYRAVADWPVLGRKLRKDLARVKNALPSVPSDAVRAYVQTGKLTVDGIELVTGDLTVQRYIELPEQVAGQSGVAQHATHTDNDVVVRLDIEVHAELQSEWLARELMNRIQKLRKRAGLQATDDVDVFYEIEEGAGADLLEALRSHAKVIQKTVRSVPVEVKRRKGPQKVLIEEEQEVADVKFMLSLAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GH57</accession>
    <name>A0A401GH57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0312420</name>
        <name evidence="3" type="ORF">SCP_0312550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612426.1">
        <property type="nucleotide sequence ID" value="XM_027756625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GH57"/>
    <dbReference type="GeneID" id="38778430"/>
    <dbReference type="InParanoid" id="A0A401GH57"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="102" mass="11132" checksum="ED6AD2BBBA9ADA0D" modified="2019-05-08" version="1">MSSKCARKANPYLDIEAIVDNEEEEKEEEEEEEEELTELLADVQRTQQARAHLDNACVGDDAADAEAMARSITERDMAARCAQRASQSGGAVISLAPDGIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIJ4</accession>
    <name>A0A401GIJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0404000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612937.1">
        <property type="nucleotide sequence ID" value="XM_027757136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIJ4"/>
    <dbReference type="STRING" id="139825.A0A401GIJ4"/>
    <dbReference type="GeneID" id="38778941"/>
    <dbReference type="InParanoid" id="A0A401GIJ4"/>
    <dbReference type="OrthoDB" id="3188789at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43994" checksum="803BFA9A395A5BCF" modified="2019-05-08" version="1">MNMPSPIVILRLVFFASLFYLNSLALGIAAWNIAALKSYGIHAYGPPIFVIMNALILFFFLVVTTASAFVPTRWAPRIMFECGWTGILCILQLSSALDITISGPPSTCPSGAYKAACASSTILVAITWISSSLFTIYFLGLFSLAVTHSSIYPGIWATSVAAVPWFSETETTPVNDSRSSLDSFRDEKRKSFIYESPVFKGLTGAAHVPPQAAPSRILRPAKRVSSVYDNPVFGEYTGAADEEARTASFFSYVFVGPPRQISSPIPVLINNSGSDRPPWARAIETRRGLDKPFPSPTKEKLVPGPEREPVRLKSTWSDTTTASTPALPPKALTGPVRVAGKPNGRSGSGQYESLHQAIDLPVIVPSPSRVESYGMFPEDVDDPDLPIDTHSDRSEWTTADPSSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIV0</accession>
    <name>A0A401GIV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">SCP_0404870</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613020.1">
        <property type="nucleotide sequence ID" value="XM_027757219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIV0"/>
    <dbReference type="FunCoup" id="A0A401GIV0">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIV0"/>
    <dbReference type="GeneID" id="38779024"/>
    <dbReference type="InParanoid" id="A0A401GIV0"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000161">
        <property type="entry name" value="Small COPII coat GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 21" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 21" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="GBE82107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="189" mass="21550" checksum="124A5B04057D8B8F" modified="2019-05-08" version="1">MFILNWFWDILAQLGLLHKNAKILFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHQQARRLWRDYFPEVDGIVFLVDSADFERFAESKAELDSLLSIEELSKVPFLILGNKIDAPGAVSEEELRHHLGLYQTTGKGKVPLNDIRPIEIFMCSVVQRQGYGEGFRWFSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIY0</accession>
    <name>A0A401GIY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0405160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613049.1">
        <property type="nucleotide sequence ID" value="XM_027757248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIY0"/>
    <dbReference type="GeneID" id="38779053"/>
    <dbReference type="InParanoid" id="A0A401GIY0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="239" mass="26024" checksum="0BE02F8DD493C693" modified="2019-05-08" version="1">MSFNGNLSPSSRASSGRARGESRGRRRQFYESSGSSTASEESLIFPMDRERPLPHNSPAASLHSRSRSPSVEGFSACVLYHGALSARQVQQRERACQTCRSHYPSSNSNTDRDHRTNDAGDGGLAREPSDAFGEGEEEGYISASAGATTALGSSMGRLFPRAREDDLPAGLVESTLPDPHFYVGSPPRPRTPWVYLSNSGWESPETHEESTAAYQRPDESHDASSRSSSAHQRYSPRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJQ3</accession>
    <name>A0A401GJQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0407660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613295.1">
        <property type="nucleotide sequence ID" value="XM_027757494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJQ3"/>
    <dbReference type="FunCoup" id="A0A401GJQ3">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJQ3"/>
    <dbReference type="GeneID" id="38779299"/>
    <dbReference type="InParanoid" id="A0A401GJQ3"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE82382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="875" mass="95024" checksum="B2379DC0AC068B83" modified="2019-05-08" version="1">MFAAANSFFGRTNISQSYNIATSLSVNSRTSTPTPSGSSSTPLPVATAHAPPFHVGPWRVQSATHKVTHKRVSVWSADKRSQEMEKMGAVSKERTLEVLKSEASALSRLRHPSILEMVEPLEETRNELIFATEPVLSSLRLSIPGSSHYSPLVELDEVEIQKGILQICKGLAFLHTSARLIHSNLTPESIIINSSGDWKISGLGLTIPLTTSGGGPTRWEFPTFDGRSPPYTQRSFDYIAPEYALDEVLDTASDMYSIGCIMYAVHSKGNPPFKNHGSLGGLRENAGKPLAGMDRWDSDLRVVLNSLITRHAHNRPTPMTLPSHLFFSSLPISTLNFLDRSNFAAKSLEEKISFMKGLTGVLGKFSEALRTRKILPSLLEEMKDTHLLPYILPNIFAISQILTSSQFATLVLPNLKPLFTIKEPPQNMLTLLDNLEILQNKTEKPVFREHVLPLVYNALESEHAVVQERALKVVPDLCESIDYAEVQGVLFPRVALVFTKTRILTVKVATLVTFLAMVKTLDQTSLTQKLVPLLSKIRTKEPAVTMATLAVQEAMGLKVDREAVATLVLPQLWAMSMGPLLTISQFKRFMEVIRKLGDRVEKEHDQYLRDSQRVEDRSTLANGDTAVPNTNIAVDFENLVASGGVANGGVTTVKADTVIDPSKAWEDDVWGSIFSSGPETPAMESLAIPPLPPPPLQPQTQSLPSSPKVSNNGVHATPARPAFSRPYPGLGATPIPSTSFNHATFASSPTVSATAMSTPTRSTPTMSTPTTSAPGMSMTSMLTPSMSSFSRPSLSSATPHRSFPAATPTQAPAPNYNISLPPAPNLPIMSSPLVATPPQMGNVLVPSKPSQPSWSSVGTTKQLSQADWGDFDPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GJR9</accession>
    <name>A0A401GJR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0407940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613323.1">
        <property type="nucleotide sequence ID" value="XM_027757522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GJR9"/>
    <dbReference type="FunCoup" id="A0A401GJR9">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GJR9"/>
    <dbReference type="GeneID" id="38779327"/>
    <dbReference type="InParanoid" id="A0A401GJR9"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="667" mass="73377" checksum="2A320640CFD54BDF" modified="2019-05-08" version="1">MSEKTREPWLNIVAHGHLRNVARTYAYLSTIDFFLHPSPSAHPPSPPSLFPSYTKMEDVFDGAVGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFSSEERLIGDAAKNQAAMNPRNTIFDAKRLIGRRYDDPDVKKDMLHWPFEVIEKDGSPLIKVEYLGEGKMFSPQEISSMVLTKMKEISEAKLGKTVKKAVVTVPAYFNDSQRLATKDAGAIAGLDVLRIINEPTAAAIAYGLDRQSSTEKNVLIFDLGGGTFDVSLLNITGGVFAVKATAGDTHLGGEDFDNNLLEHFKKEFQRKTKLDISDDARALRRLRSACERAKRTLSSVTQTTVEVDSLFQGEDFSANITRARFEEINAALFKSTIDPVERVLKDAKMPREKVDDIVLVGGSTRIPKIQSLVSEYFGGRQLNKSINPDEAVAYGAAVQAAVLTGQTSDKTADLLLLDVAPLSLGVAMQGDIFGVVVPRNTPIPTNKSRTFTTVEDNQTTVTFPVYEGERTQCRDNRLLGEFELTGIPPMPRGQAELVTTFEVDANGLLKVTAQDRASGRKAQISITNSVGRLSSVEIEQMIKDAEQFKQADKDFSARHEAKADLETYVHQVENTITSPEIGMKLKRGAKSQVEAELARALEKLEIEDSTADELRKAQLGIKRALQKATAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK06</accession>
    <name>A0A401GK06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0408630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613392.1">
        <property type="nucleotide sequence ID" value="XM_027757591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK06"/>
    <dbReference type="STRING" id="139825.A0A401GK06"/>
    <dbReference type="GeneID" id="38779396"/>
    <dbReference type="InParanoid" id="A0A401GK06"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE82479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33456" checksum="01144C15B066F426" modified="2019-05-08" version="1">MLFTFRLFNLSSIFATVWFAVAVIGIYSHSYRCRLAAPHLSWVTFAIACILYLRFIKLLLLPAYRICVRSARTDKAVPGKLTQSRVDRIPLVLYIPPPPEDAFESTSLITVPSPTHAYPPGCLVPIRPSPSGLKRRFIFLRSLRKRKDINALKGSKEDVQGNRAYAQAAWEDLWERGEHPLVRLEGQRSTCGICLMDFEAPKRILPIPEEGAESAEELADARADAEADQNGDTDAGAVQEVQVEPARQDDTHRVALADSGEGPQPLRLLGCGHAFHEFRTRKLASTRGSSVCLDVVHIASVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GK39</accession>
    <name>A0A401GK39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0409210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613450.1">
        <property type="nucleotide sequence ID" value="XM_027757649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GK39"/>
    <dbReference type="STRING" id="139825.A0A401GK39"/>
    <dbReference type="GeneID" id="38779454"/>
    <dbReference type="InParanoid" id="A0A401GK39"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="211"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE82537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="403" mass="43880" checksum="F63AA73F0519AA63" modified="2019-05-08" version="1">MEQHAQQPPWPLTLSTFLSFARPITEVSVLSSVEYVFAEIPRRLASRARSLEALPFIVGMNPFIARTLQAYRRSFQFLTMHPPVKTLQENAFFAVQLEAFVQSHANDIPTMAKGFQECSRYMTPEQISEFLDGAIRNRIAMRLIAEQHIALSRSLMQKENSRDHLGIVHMSCSPRDTICMCGSFVSELCEATLGASPKIIIDGEIDATFAYIPVHLEYILTEILKNAFRATVERHHKLYASATSTPPIPPVVITISPPPPLTSHARVGPAFLSMRIRDEGGGVPSANMGRIFSYSFTTAGRGAEDSLEDADNGLGGGPYAAQHVGGSAAVDGNGGTGGLFTEMTGRSLQMGLGTIAGLGYGLPMSRLYARYFGGSLDFLSLEGWGSDVFLKLRDLNDAGDAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKR7</accession>
    <name>A0A401GKR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhamnose mutarotase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0411410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613669.1">
        <property type="nucleotide sequence ID" value="XM_027757868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKR7"/>
    <dbReference type="STRING" id="139825.A0A401GKR7"/>
    <dbReference type="GeneID" id="38779673"/>
    <dbReference type="InParanoid" id="A0A401GKR7"/>
    <dbReference type="OrthoDB" id="9981546at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008000">
        <property type="entry name" value="Rham/fucose_mutarotase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34389:SF2">
        <property type="entry name" value="L-RHAMNOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05336">
        <property type="entry name" value="rhaM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE82756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14641" checksum="3F6929817C6FFF3A" modified="2019-05-08" version="1">MSTVESKRICQIIKLKPGAEQEYKALHAAAWPGVLAALARYHIADYSIHYYAPLRLLVAHFKYTGTDYAADMRDMAEDAETRRWWALTDRLQESFVEGATGSGGDAPWWLDLEEVFRFEGYAAGTTSMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GKX5</accession>
    <name>A0A401GKX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SLC41A/MgtE integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0411870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613715.1">
        <property type="nucleotide sequence ID" value="XM_027757914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GKX5"/>
    <dbReference type="GeneID" id="38779719"/>
    <dbReference type="InParanoid" id="A0A401GKX5"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="124"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="11">
        <location>
            <begin position="374"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE82802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="530" mass="56575" checksum="DC73E37758B8ABD2" modified="2019-05-08" version="1">MEGAVSSDPASEISSETIELTTLDGTTETDDQKSAKPLVYELADDSDGDSDDEGEGNRALLGSLREERVFVGHTSRWAQVKSLVIETSPTLLITTLGLLFTGEILTNVSHWKAMSRVDELIMIIPVVLNLKGNLEMNLSARLGTAANMGELDEPSRRKSIILGNLTLLQVQATVVSFVAACVAFLLGRIIPRPAGEEAVSAVLSGNITSSIVARTVGARTPRPIFPGGSPTSGLSEFAMVASAAMTSTCLSGCVLGSFMCTLVVLCRRFGLDPDNIAPPVAACLGDLVTLTILGVVSALHLLIIDTVIPLIIIIFLVAAAVGWTVLTRRNEHVQHLLTEGWMPLFIAMIISSGTGLVLDTFVGQYTGYALVAVVVTGLSGNVGSVFISRLSTALHAATFTLPTVLSDLPTLDQADEKSPHPSQRMVMITLLLVSLPVNIAFLATVFAFGWLRLSFLFIVLQVIFFCITTVISLFLAQVTTNLLWKRDLDPDMYALPLNSALVDLVGQLLLVCCYEIAALLGSHVRSHAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GL95</accession>
    <name>A0A401GL95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0413110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE82924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613837.1">
        <property type="nucleotide sequence ID" value="XM_027758036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GL95"/>
    <dbReference type="FunCoup" id="A0A401GL95">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GL95"/>
    <dbReference type="GeneID" id="38779841"/>
    <dbReference type="InParanoid" id="A0A401GL95"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="414"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE82924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="862" mass="95121" checksum="0287A30C3DDDB390" modified="2019-05-08" version="1">MPPSDFANVDLADVVDQLTTDEAILLTAGVGFWHTHAIPRLNVPALKVSDGPNGIRGNHFFMGTPAKCLPSATALGATFDPDLLHDVGLKLLAQEAKLKGASVLLGPTCNTQRSPLGGRSFESFSEDPHLSGMIAASYVKGVQEGGIAGCIKHFVGNDKEDDRMAYDSIMSERALREIYLMPFMLAEKYAKPWSFMTAYNRVNGTHVSENPKIIRDILRNEWGSDATVMSDWFGVYSIDHAINAGLDLEMPGTNKWRTLDLMNRSIQSRKIMRRTVKERAAKVLQLVQKCARAAPEILDGDGLERTVDTPEEKALMRHLATQSIVLLKNDKGVLPLKPKEQNLKKIAIVGGNAKALVLSGGGSAALKPSFFTTPHDGIVAALGEVDKNVEITYCEGARAYMQMPSLDYDIFTDKGQRGWIGSFYSHESDNSMTPLSEPLVDRYIDETRIFFSTSYDERLTKRWTLKLKGQLKPRPYDCQFEFGLLSAGRARLYVDGKLLVDNWTKQRRGSAFFGSGSEEEKGIYPLKAGIAHSILVEYCNVRAPADDDLDEMLMDSNPGVRLGGAEVEDPDALMERAVKLASEADAVVAVVGLNADWETEGYDRTTLALPQRTDELVSRVAQVNARTIVVTQSGSSITMPWVDQVPAIVHAWYLGNSTGEAIGDVLTGKVNPSGRLSLTFAKRLEDFPSHGHFHSENGKVRYAEDLFVGYKHFHHRKIEPLFPFGYGLSYTTFQYSDLKLSKPAVFNGEFELTASVTVTNTGTVAGSDIVQLYVTLPSTSELTHPPLMLKKFAKVKNLAPGKRISIVLELDKYAVSYWEDRISRWVVETGEYLVRIGKSSAPKDLGLAATFTVEKGFEWNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLF7</accession>
    <name>A0A401GLF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0500480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613918.1">
        <property type="nucleotide sequence ID" value="XM_027758117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLF7"/>
    <dbReference type="STRING" id="139825.A0A401GLF7"/>
    <dbReference type="GeneID" id="38779922"/>
    <dbReference type="InParanoid" id="A0A401GLF7"/>
    <dbReference type="OrthoDB" id="2797670at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF7">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE83005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="260" mass="28965" checksum="DA355A758816AAB5" modified="2019-05-08" version="1">MASLNPHVKLPTLTGDNYYDWKFAVSMVMRRNMCWDVVSGKVSKPAEDKLGDWPKKAEDGLTLIGLTVDPSQYGYIRDCADGPAAWKALAAVYEKNSRANRIALKRQFYNFVHDPKCPIRDYISGITNLAAKLKGIGVALEDEDVTDVLIFNLHEDYSNIAGTLTATKGDLKIADVTGALVDEEGRRGGLPKADDEKEVENMALFAQKERDNRNRNVECYNCGKRGHIARDCRLPGRYNEKNSAKAEKASVAFDLRDVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLH5</accession>
    <name>A0A401GLH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613938.1">
        <property type="nucleotide sequence ID" value="XM_027758137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLH5"/>
    <dbReference type="GeneID" id="38779942"/>
    <dbReference type="InParanoid" id="A0A401GLH5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="98" mass="9606" checksum="E805084AB9C93151" modified="2019-05-08" version="1">MANRGQSTSVASAPSLSDLQDQIRALSADISQTEAIALKVQRAMEIIRAALGINTGGASPSSALPSSAPPSSVLPSSAPPSSAPPSSASFSSNVTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GLI5</accession>
    <name>A0A401GLI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0500780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613948.1">
        <property type="nucleotide sequence ID" value="XM_027758147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GLI5"/>
    <dbReference type="GeneID" id="38779952"/>
    <dbReference type="InParanoid" id="A0A401GLI5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="696" mass="76128" checksum="C55ADF5418845992" modified="2019-05-08" version="1">MTLPRITRIHSFKGTKGPYLAEEWAARRLGRRIFPSHHDYTKAVLKDYDAGGRHHPACVAARTADARSRRVLDSVSVARHLAMGEFAVVGIDDNRHTLVDIGCLLHVVPQPPVLEDVHRTFRRCTDFERARLSSVEGTFNLEQWMPKHISDCLRLNCHFVALGPAIATQTVARGLPLIRHHSLTLAHYSYSPDSSAIHDRDFTEAPCVPSTLDLLIHARTASIGMDIDDPDKTLVNDIPVMDFEGVSPTDICVESLNIAPVPFAEATVKCDDEEMQDSFALGSARVTNRVDRVVDPRRRPPQVTTAARVSKSTCTSNITHKDDEMRDDFIIVGSGGVAEKEGRVADPRRLSQSIAADRIPTSIYRDKILNGSFAVEEEAWAGDPCRRPPQATHPALKSTSIKANAFATLGFAPTSGSCNNFDTADGCYTMDKESNMNEEDKAVAIPNSPSPVQISAPVVSNMEDLSNLFMTLGLPTVENYDAESVVVNDDLPIPRPPTPPKPSRSPSRALVLPAIDIGDNDEQLSSDFDNTGSVGLDNMTELNIEQAEDDEDDVPQHEKGRALTAREVLEREVFGSDSEDEDDDSPPLPVLLAVDVIHDDKHLPSNYDYTGSNGDADDDVDDHSALQAEDREGGVEDGQAPEQDDSPPTTTDLEREIFGSDSDDEDEDSPIQSCSIDTLLPCAATFGNMVAHIRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMG3</accession>
    <name>A0A401GMG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0504300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614295.1">
        <property type="nucleotide sequence ID" value="XM_027758494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMG3"/>
    <dbReference type="GeneID" id="38780299"/>
    <dbReference type="InParanoid" id="A0A401GMG3"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE83382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="77" mass="8760" checksum="AFC74B43B72029FA" modified="2019-05-08" version="1">MSNGTTFLVTPPYALQDIPVPQSSCFSMRKRVFPHLDLDHLPESLELGWKDGLSLGVYHINTACVRRESAEDMDRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GMQ7</accession>
    <name>A0A401GMQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0500770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027613947.1">
        <property type="nucleotide sequence ID" value="XM_027758146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GMQ7"/>
    <dbReference type="FunCoup" id="A0A401GMQ7">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GMQ7"/>
    <dbReference type="GeneID" id="38779951"/>
    <dbReference type="InParanoid" id="A0A401GMQ7"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="104"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE83034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="412" mass="43682" checksum="8D579D5E216377A2" modified="2019-05-08" version="1">MLALLVSAGPVVKERGVHIPLQKRGSLKKMDGTFDYERHARQLVKIQNKHRQNLVNLQNNTGALPAGAFIPQALHHHATQGENSRRRYKRQALPLTDQQDGLEWTGTITIGTPPISFVVDFDTGSSDLWVASSECNQCGKHNTYDPASSSTSSSKDGNFSISYGDGSSDSGPEYTDTVTLSGVTVTGQALSAVTSESSEFQTDPADGLMGFAFPSISQLQANPFPFAALSESAIPQGVFSFKLTSDGAELYMGGADSSLYTGDIEYHSLSADNGFWQIGGASVLVNGQTTVSGLDTIIDSGTTLAYGPTATVSQLFQAIPGSREDKDGTYTFPCDAQLTVAFSWGGNTWAVDPNLFNQGATKQGSHQCVAAIGASDDLGFGENVWLLGDTFMSNVYTAFSMDDNAVGFAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNR3</accession>
    <name>A0A401GNR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0509150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614771.1">
        <property type="nucleotide sequence ID" value="XM_027758970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNR3"/>
    <dbReference type="GeneID" id="38780775"/>
    <dbReference type="InParanoid" id="A0A401GNR3"/>
    <dbReference type="OrthoDB" id="3320394at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE83858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="466" mass="51997" checksum="292103BDD4CEE725" modified="2019-05-08" version="1">MARHGRKSGHLTATRKKPGRPPEQPAELGPDPKLTHLLLKLPPHLPPSHPPVQSLIENYISPSSSSSNEDVLYGAQVTQDDNDDGVVHNSETDGDDITVTEPASQSTQGDHGKVITPLHAQPVEVEYMVPKHDGKAMKRVPLSSAMTWDIVRERLRIVMGYDNVDDMALSYRLSKDAKSVRKSLEDDNDYQGIVQSMQSHRRNTRPQQVIILDDSVNDSEQELSQPKGSHKKAPGMKAAAVAHAYATVEHQSQIDEVVEELKRQNPKCSEHAMSCWLGHPSGEHVQLTEMRFAAWATDIVKQLSLPEMERTVTYTHPPNNRMFDVPPSFRHQHAPSVSKAPSTSMPVPPIIINMPEMSGSHKHLIVSPSSSDPVNPADAPWPSLTDFLLHAVTVDRHSRNYPAYEPGLRQADLLGPDDIEKCTEEELKKHCDIPIGAGRFLIHEAKLVCKQIRQQAQIPQKRFRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GNR4</accession>
    <name>A0A401GNR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0509100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000005">
        <property type="protein sequence ID" value="GBE83853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027614766.1">
        <property type="nucleotide sequence ID" value="XM_027758965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GNR4"/>
    <dbReference type="GeneID" id="38780770"/>
    <dbReference type="InParanoid" id="A0A401GNR4"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="52"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE83853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="342" mass="37198" checksum="4A2B53ACD289BCE5" modified="2019-05-08" version="1">MSTDYEKPGTGEEDEHMQQLEVPDEKVLDGALPSPVSAPVPRSSKSTKLSAAAIIPIWIVLSSSVIIYNNYLYNTLEFRFPVFLVTWHLTFAAIGTRVLQRTTHLLDGAKDVHVSKDMFLRSILPIGFLFSGSLILSNTAYLYLSVAYIQMLKAFNPVAILLISWTFRIQDPNKKLAMIVFMISAGVALASHGELRFNLIGFLTQAAAVAFESSRLVMIEILLHGLKMDPLVSLHYYAPVCALINLLVLPLTEGLAPFYEVMRVGPLVLLSNACIAFMLNVAAVFLIGAGSGLVLTLAGVFKDILLITGSVLIFGAMVTPLQVVGYSIALCGLVLYKTSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPD9</accession>
    <name>A0A401GPD9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0600730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615008.1">
        <property type="nucleotide sequence ID" value="XM_027759207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPD9"/>
    <dbReference type="STRING" id="139825.A0A401GPD9"/>
    <dbReference type="GeneID" id="38781012"/>
    <dbReference type="InParanoid" id="A0A401GPD9"/>
    <dbReference type="OrthoDB" id="3258904at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE84095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50293" checksum="E457D9D46160EF4B" modified="2019-05-08" version="1">MSNGSVSFLPSQVDAPVSTRPLTTSASPFDLLYADIVLFFQNWRYLPGIVLPLTPTPSGPLDELYPSVANLWAISVHVVLIVIEGVYILSIPLSPFFVNAAFIAYSGTVLIIVYMICFLLNKGVSGEFVFSDEHLLEGYEKRDGEVWVFVNGVAVGKHWLKSNVNRLSETFRRRIIGVHNPTGGIIFDVIQCLVQRDFSYDTPDVRQSYAYLKTALLDQSVHKVVFLAHSQGGIIASMALDWLYAELPAAALSKLEVYTFGCAANHFNNPARRASHVHPYDRQPNGTSPPAPTNGHTPHDARIVPHIEHYANGRDFVSRWGVLHFAASACANRFAGRVFEQRGASGHQLDQHYLDTMFPLDAARTRVREENAFMDAPCEVDAELVVAREQPAADAIGRARRKGSGEELRRRYVDAARAQAAAARTMRVKDLSRLWLYRNGEVPEHIPASPIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GPT9</accession>
    <name>A0A401GPT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0602150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615150.1">
        <property type="nucleotide sequence ID" value="XM_027759349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GPT9"/>
    <dbReference type="GeneID" id="38781154"/>
    <dbReference type="InParanoid" id="A0A401GPT9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="109" mass="12440" checksum="2E67CC69E89D95B3" modified="2019-05-08" version="1">MPWLKRLNLMINWETGDFWFGKDAKWPPKPTVEDAPDEEVSIFKEDGLLELITTETSPTSFGHSESIREIMADNTEHDELPAVRNDTEPDDPPSEPPMDQLDDDDLVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GQS8</accession>
    <name>A0A401GQS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_0604990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615433.1">
        <property type="nucleotide sequence ID" value="XM_027759632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GQS8"/>
    <dbReference type="FunCoup" id="A0A401GQS8">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GQS8"/>
    <dbReference type="GeneID" id="38781437"/>
    <dbReference type="InParanoid" id="A0A401GQS8"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE84520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="309" mass="34262" checksum="C2D385164161D826" modified="2019-05-08" version="1">MSYYSNSRSPPPLQHPVPTHPAYIPEPPSTPASPQGYQRYTSSPPVQQQYAQPMPPSGPSGRSPSGYVASTPHYRPMSSPPRHQSVHGQPHPHMSVPVDFSAWGLNDATAQFGMQLGQNAVAAGQDYVQRNLGGLIPITVLKHHFNVSNSYVIKKLQLLLFPWRHKPWSRRVRRTENGQSDWQPPRDDINSPDLYIPLMALVTYILLAALHSGLNSRFHPEILGITASKAIAVVLLDFIFMKLGCYFLNIQGGLSDQLLDLMSYGGYKFVGVIVTLIASLLNFGLTLYTAVFIYTFLATAFFLVSNVCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GR49</accession>
    <name>A0A401GR49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short chain dehydrogenase citE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0606880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000006">
        <property type="protein sequence ID" value="GBE84708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615621.1">
        <property type="nucleotide sequence ID" value="XM_027759820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GR49"/>
    <dbReference type="STRING" id="139825.A0A401GR49"/>
    <dbReference type="GeneID" id="38781625"/>
    <dbReference type="InParanoid" id="A0A401GR49"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE84708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="306" mass="33808" checksum="994ABAB838DD5918" modified="2019-05-08" version="1">MPNSTGLDFVPTTHHDTYPAIDPNKADLSGKVVLVTGASRGIGRATAIAFTQAGASGLVLLARSNMSAVETECLAVRRPGRQIKLLLLSVDIRDPAQVIEAARQVEETFGRLDAIVNNAGYMETSKPMAESDPYDWWKVWEVNIRGVYNMSHAFIPLLIECGGDKLIVNMSSGMAHLIWAGSSAYQVLSHLLFLSMHLTRTGKTTKFALLRITESIMADYGTQGVLAFALHPCITPTELNAKWAPEVRKMCIDTPELGAHTVVWLMRGRRDWLGGRYISANWDVDELLAKRQEIVDGDKLKMRMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GS46</accession>
    <name>A0A401GS46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0702310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027615958.1">
        <property type="nucleotide sequence ID" value="XM_027760157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GS46"/>
    <dbReference type="GeneID" id="38781962"/>
    <dbReference type="InParanoid" id="A0A401GS46"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="12974" checksum="97753CCBF4AEB11D" modified="2019-05-08" version="1">MHDLSRAGGSSPLSTLPAEPTRTPLHVTERWLCTIRPENDRTRSRAEADYACCLQRGTTSSHNRRDASRKTTAAASRVETTTRAVRGPQPGEKAICGWLRVEQYAHANAEAVSLTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT54</accession>
    <name>A0A401GT54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mug135-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0705370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0612 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616263.1">
        <property type="nucleotide sequence ID" value="XM_027760462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT54"/>
    <dbReference type="STRING" id="139825.A0A401GT54"/>
    <dbReference type="GeneID" id="38782267"/>
    <dbReference type="InParanoid" id="A0A401GT54"/>
    <dbReference type="OrthoDB" id="2803487at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013902">
        <property type="entry name" value="Mug135-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08593">
        <property type="entry name" value="Mug135_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mug135-like C-terminal" evidence="3">
        <location>
            <begin position="133"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE85350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="226" mass="25583" checksum="DDC37C4366309BEB" modified="2019-05-08" version="1">MSDSSLTDIEDEDVQNAQPAVLIQLPIEAGLDLPPQTHIPPSDFDICQAKLYEREVEYNYMRRQANNAQFASAIKYKASVVAASDNNAAPAWFNQSMRDLRRDMRRGFQRLRRRLDDTNRRLADTQRTSGKVYNSTNAKGGAVPFVQIPWEDGTYPWGFVHRNQPLPALTSVAVVEGLDGHQSRKIYHGYYPNNDVPENQEERVTAILVAIGCADRSRLVRPDHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GT61</accession>
    <name>A0A401GT61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0705600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000007">
        <property type="protein sequence ID" value="GBE85373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616286.1">
        <property type="nucleotide sequence ID" value="XM_027760485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GT61"/>
    <dbReference type="GeneID" id="38782290"/>
    <dbReference type="InParanoid" id="A0A401GT61"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="116" mass="12905" checksum="8E8A55735998E14C" modified="2019-05-08" version="1">MVVYVLRTSSNAEADPGPSPAVTYAGMYAVLAAPPLLPTAPSCTRACVRRPSIFGIDELERGDRVRKRIRLEDPSPYICMHTRDPTKCKYIHVAVSPSHHTHTRTRAQCHRHDITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU02</accession>
    <name>A0A401GU02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">SCP_0802080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="3 12"/>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616599.1">
        <property type="nucleotide sequence ID" value="XM_027760798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU02"/>
    <dbReference type="FunCoup" id="A0A401GU02">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GU02"/>
    <dbReference type="GeneID" id="38782603"/>
    <dbReference type="InParanoid" id="A0A401GU02"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="378"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="GBE85686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="444" mass="48720" checksum="BD0A6092F052A973" modified="2019-05-08" version="1">MMSTLAEQKYNLITRRLQEVLGGDGIKAILAEDKAPKCYWGTAPTGRPHIGYFVPLTKIADFLRAGVEVTILLADVHAFLDNMKAPLELVSHRTKYYQFVLLAIFHSLGIPTSKLRFVEGSSYQLTKEYNLDNYRLCAIVTEHDAKKAGAEVVKQVESPMLSGLLYPGLQALDEQYLGVDFQFGGVDQRKIFTFAELYLPRLGYAKRAHLMNPMVPGLAGGKMSSSDPDSKIDFLDSPEVVRRKIKKAFCEEGNVTENGVLSFVEAVLIPISQMRLERQRGDTGLDSDEGTESTGDQSPFALPGAPTNTVFSVHRKEEFGGSLHYATFEQLQQDFAEKRLHPKDLKTAVADAIVRLLAPIKNAFNENPEWQEVEKLAYPDPNAKPVKAKKEKVYHPPPPGKGKNAKPAATAPKVNGDAAADALPSTDPAAHVVAEAAEQQDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GU32</accession>
    <name>A0A401GU32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0802380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616629.1">
        <property type="nucleotide sequence ID" value="XM_027760828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GU32"/>
    <dbReference type="GeneID" id="38782633"/>
    <dbReference type="InParanoid" id="A0A401GU32"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="889"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE85716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="979" mass="108083" checksum="99C4D0DFA6CEAD24" modified="2019-05-08" version="1">MWVLSGPFDGEDADNLSKINLKLLKTGKEYIVGRKDQPLLIRNKKVSHRHAIFIVKECTEDDVMNSAFKPELILEVFGKPRHIQRPGRKEPLTVNPGQRAVLKHDDSVLMVTGVEVKILWENVCCYSPAPRARLPFSLQSCASLGVSMVVTPRAEVTHHLTPTYTLSPLIAISLISAAQFVKPEWLTDLLSLGESINGAPSMLEQKFVLPPVTKYHPAFSPMLPVALRSFHVWQPDEARVGMFRNYRFIFVGEKGREAQEMMRELVKSGEGEYECCSVDGGRRGLHQVLAKGKGKKRALTLVADEDSIVAAVGDDRWQELEEEATSFDLTFIPHEKILEAVVRADASFLVASSKQQASSPLPDAIPNTIQDEPTFPPHLPRSEPQSAPAPAPETGPPRRRLPRRATSRASSRAPSPPSAASDAAEGQTQAMEPPKPRRTLVRRAGRSRAPTIIGIDDPSMILDGDSVAGGPSAGPEEPAPVEPEGPSRTTAATPGRSSRLKRRVGATQMPPSLLGLSEDVAIPGAGEPPLKKFKALFEESDPDRIAQSQLLGSTGEPLDSQYPYEKQSLTQSESGMTQLPGRTRFGGELLMAVAEEEEEDTTTADVRSQMFGKLTRGAKRKNQAEDGVVQMDEPEPKHKRRAIENVNAVEATTSQRGTQKPPSTVAKPPSKPATQAQKIQKTHGRAGAAPGKPDTDQAFLKAVASTKRGKKIEDFFDREFNNLKISKPDLEHDQQQKEWDVLDDFGDDHNLRGNFMLIMEMDVPEHREGRQPLRRGRERMDWEGRPDFKKFMKKVVIGEGRPLIELLVDNKDYGMESQHLEDGSQMFSQSRSRSAEQPEGRSSKRSQRSGKFVMQTQGKGKSKATAPAVSDVDSGDEEIPQPRTRKKTQTQTQTQSKKQPLFIESDEEQSQGQAVNDDVFDKGFDDDDEELTLRSSGSRTQTTSKKPSAQARGPRKQTIALDVDSDDGATFKGFGARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GUC3</accession>
    <name>A0A401GUC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Damage response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0803400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616731.1">
        <property type="nucleotide sequence ID" value="XM_027760930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GUC3"/>
    <dbReference type="FunCoup" id="A0A401GUC3">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GUC3"/>
    <dbReference type="GeneID" id="38782735"/>
    <dbReference type="InParanoid" id="A0A401GUC3"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE85818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="165" mass="18512" checksum="255CF3AE41A96094" modified="2019-05-08" version="1">MAFDLGTPVNTALLIYILYLLQRIVFPSNSISKTIPTEFKNGYSWMPKSHPPTLLYQTYTPKTLSPFNGEDGKRILLAIDGVVYDVTAGRNFYGPNGMYANFSGRDASRGMAKQSFELDMLTPIDQPLDKLDDLTPAEIDNMKGWMEHFSTKYIVCGKLVENDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GV84</accession>
    <name>A0A401GV84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc phosphodiesterase ELAC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0806230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE86099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617012.1">
        <property type="nucleotide sequence ID" value="XM_027761211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GV84"/>
    <dbReference type="STRING" id="139825.A0A401GV84"/>
    <dbReference type="GeneID" id="38783016"/>
    <dbReference type="InParanoid" id="A0A401GV84"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="545" mass="60301" checksum="96B8F2A9E6436AE8" modified="2019-05-08" version="1">MSNDITVTFLGTTSGGGPTETRNCSSLVLDPLSDGSLWMVDCAEGTARQVATQPWHDSRRIKLTRLTKIFITHMHADHTMGLLPLLRNVLGIPRLRPPFREPDDPPRVEVYGPRGLRRLLRTLCAATNTNTDTRYAVHELLFPGEEPDVNAPESSLTSGPPAKNSVGWNEHVECEAPGFNFACDADGFWRGIVDTPIAGSHGRRRLVVDAGPIEHRDPCLGFVFREVVDPDVPSERERPPRTLVILGDTYDASGILPLLSSPSRPLDMRFPSSDPLLTDATPPMPARITLLIHEATDACIPRSIDTQERTGRNRTPQSVTETAVARGHSTPAMAGAFARACGAERLVLNHIGARFPAPRGPEDTFRVMCMAEIERQAATTWAPPPGGFVQAAYDFMRVTIPPYPSPVELEMEGLIVQEVEAFKEVNQLNKSQNKVDARDAGPPPPTGPRAGAYLSTDANLNRKRERVLSERAHGASDIGRDAKRNMSTYAGSSAYAARDQAYYENGRAREDRGARYEREDRRDNGGRRGGHWREPREEYRPRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVF8</accession>
    <name>A0A401GVF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0802560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000008">
        <property type="protein sequence ID" value="GBE85734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027616647.1">
        <property type="nucleotide sequence ID" value="XM_027760846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVF8"/>
    <dbReference type="GeneID" id="38782651"/>
    <dbReference type="InParanoid" id="A0A401GVF8"/>
    <dbReference type="OrthoDB" id="2754227at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE85734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="155" mass="17641" checksum="6D4ED9EF3F11ABEC" modified="2019-05-08" version="1">MAKPDYARVTTQVFTQEDSKTQLNLIWPYNSIEDSEPEDAVLHMQGFLCKKDLPPIVQNDQLPSKLFRATQSVKLTGLGSPTFAEAVKGVIAIHQLFAQHLDKGMLIPWSPIREHDELVLEFSNRYLSCMRDMEDDNEIPIGNDIDPFGILRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVJ0</accession>
    <name>A0A401GVJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0901300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617164.1">
        <property type="nucleotide sequence ID" value="XM_027761363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVJ0"/>
    <dbReference type="STRING" id="139825.A0A401GVJ0"/>
    <dbReference type="GeneID" id="38783168"/>
    <dbReference type="InParanoid" id="A0A401GVJ0"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE86251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="566" mass="61682" checksum="2FE3CD8176EC04E5" modified="2019-05-08" version="1">MPPPSEIPTLIVGAGPAGLALALTLIKNGVKVRIIDKALDYHIGTRGSGLQARTLEVLHFLGVLPDIQAKAIPMKPRRLYKLPRGVEPIDTRYMLPPMDPTPSVPFVNALMLGQESSESILRTHIEKLGSHIELSTELRSLEQTADHVVAHLVKICGDEEISETVTCLWLVGVDGAKGVVRKQLGLSFLGETRVEESIIVGDIELRGLDTDYWHTWGDRFTTFVMLRPTETDGLFNFVLSGQMDYSLVISDHAELIRALRAGTDRNDLVFGRVRWISNYTPNIRMVEKFADGRVFLAGDAAHVHSPSGGQGLNSSVQDVFNLGWKLALAIKGVAAPSLMSTYSEERVPVIREMLTQTTKILDKVNAARADDRSSQQVAWTRGRQIMMLGVNYRWSSVVVDERVQDTPEEQALSAYGGEGGKEVRAGDRAPDAPELVVLGGSEAAAKSTPTSLFEIFSPAYHTVLLFSDDASSEQLCFVTQELALLPKDLVRLVTVYPQGARRPEDVGAASAHFNLVDGSGHAYGSYSIPEKGLFVVIVRPDGVVGAMVSNAEGVRQYLQGVFSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GVL8</accession>
    <name>A0A401GVL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0901440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617178.1">
        <property type="nucleotide sequence ID" value="XM_027761377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GVL8"/>
    <dbReference type="STRING" id="139825.A0A401GVL8"/>
    <dbReference type="GeneID" id="38783182"/>
    <dbReference type="InParanoid" id="A0A401GVL8"/>
    <dbReference type="OrthoDB" id="3267359at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="928" mass="99135" checksum="7877929E868A876A" modified="2019-05-08" version="1">MRGLTATLPSDGPYFVVYRLGLMTVYKDHPEGIALGIYTEPFPIVLKLHKLAEVEEAVTLQAVFDDEHAHLEGLLDTLQNSHEVRNTMKKFVDLRYYAVGRGKNTGIYLRWDGRNEAKEQILGFCQQKHKLFLVLADALVYYMCKGPRPEPVKLALSSQRSGMPRTVQASQTSSMQSTMQAGGTLTGQSIAWAPTQVVTPHSPAAAQPSTGHLGVNIPVSIMASLRLGENSHGTPALPSTPPRSPLVTVSSTPVSSSPAFRNAAMCSPISIAVSTSHHGTSTSSSPRLQERFSSHNIEYYHQEVMQRSHLVSLKRKVSRWNVFQCMEVQCMNQALPAGTLHKKASAYMAEISATWNVMSEADKLKATAKHNAPINVFHDARSTLNNISRELEGLSQRTGTETNDCLPEYFYLKTKTDILTFAIKMESYGISGMEGVVMNHVEEILDLKWRISALIIQKLHECYIISMFCMRLMKITEDISPLKISKMYYKGFEKRITARYRITVVNWPLKEFKSPGDISHKGDLQLLYRAWESSTTHFKLLSNEEHKKWEEEQFQERMWEMHGPTAEDEGEEDELNGVLPTSPVQSPAPESTTSNSEPIDDNVRATMTINEGAGSANNDTSSPSSAALIVGQGASSQMSSSAKCHAPANGAGVHKKAKTIQPLSSFINIVTGADGNPLTVQKKTRKECSDKGMKKGPRKKQAAGNENTNPSSTATSEPAPPVSVPFTLAASPHRPSTHRRHVPPALASACNTTSAPVVASPTATGPTIPIPAAAATTPGTPSTFAPGGAPSPFVPDAPSTFTPGDAPSTFVLSSPSTFVPSSPSIFVPGAPATSAPSAPATSALSAPSIFVPGAPSIFAPGAPTTSVPSAPATSAPGAPATSVPSASATSAPGAPATFAPGISTPFVFVPAGPAPSPFVTDASPLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GW22</accession>
    <name>A0A401GW22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0902610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617295.1">
        <property type="nucleotide sequence ID" value="XM_027761494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GW22"/>
    <dbReference type="STRING" id="139825.A0A401GW22"/>
    <dbReference type="GeneID" id="38783299"/>
    <dbReference type="InParanoid" id="A0A401GW22"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE86382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="275" mass="29630" checksum="7D3AA9395BA52B21" modified="2019-05-08" version="1">MLRTLTTAASQSTLISLTSPLNRSSLTAIRSTLAASFDENENVYDPAETHATVLVPLCNVNGRPGVLLEVRGKLRTHSGEVSFPGGKVDKTDESTVAAALRETQEEVGIHPDQIEILGRFGPAEHSLGGMRVWPYVAFVHADSGLVSDTASSSAFQADGDTPLPSLPMSSLILSPSEVAHAFHLPLSDLVSPPRLRSYLFRGARPYFAVSVGDIVTGPNAVHRKLPGAGDQLDLTWPNDPDQQDEIGAGRESRLEVWGLTGWYLSTFMQILGVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWA0</accession>
    <name>A0A401GWA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0903420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617376.1">
        <property type="nucleotide sequence ID" value="XM_027761575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWA0"/>
    <dbReference type="STRING" id="139825.A0A401GWA0"/>
    <dbReference type="GeneID" id="38783380"/>
    <dbReference type="InParanoid" id="A0A401GWA0"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="662" mass="73243" checksum="D650A6AF178F406B" modified="2019-05-08" version="1">MSRIPPGLLYLTIYNPALRPAIPTQEDDEDAEEQAQILFYTARERAVSRDRILRQVGLCKALISFSELFNPENVCSNVHSQARRMVMLSPEPDFWIHACFEVAKTPRPAAARSKHQEKGKGKDHPTREDVVYDYHDGSVHDLSLRAHILFGYELFKLTHGTLTSILSSLGQNALELQLERFFTVWAWKWDIVQDTNFSAYLGVPRHPLCPSLTPVLNGFGLQCPEDTVPFVLVPPYLVPSTRFSTARYPMCLIQHIMSRIPPPLPLNGSNPTLSTTPEQRQSTSMSGTGPDERLATSDKKPHDGSAQGSTFLAMPNMNVKWNWPGYLTFGRGSSAKTSQVSPSSQDVCTTSPENSKVDEETADEDQRNVVDVDAQSLQEAISTDNIHIPASPLDTSPASSAKPLEARSTQIGADSDTIPPVSEEGTRSDTYIDVPSTVIAEAITKSKDPETPVTGRDTSSPTVSEEELFQEERKPMPSYLSTTVHLSETGEISDTRRRRIWHLTSNELTFALVTEYDSDAEQLPPAETVIAMLDRIRSVIVVEKQKAAAEATIPSAAKILQPEDRHVISAGGFTRSPSAGLSSETEQLFNGQQMLHSDLDVLEVFSRGQNPQHWHISKRGLGVGVDGLPVEGEVYMQIARKESTLTDVDNELAGVMRRFLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWE6</accession>
    <name>A0A401GWE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0903680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617402.1">
        <property type="nucleotide sequence ID" value="XM_027761601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWE6"/>
    <dbReference type="GeneID" id="38783406"/>
    <dbReference type="InParanoid" id="A0A401GWE6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE86489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="690" mass="76937" checksum="C72967A426533D39" modified="2019-05-08" version="1">MNGLQDELERKRELNLEFKTITSALEVLTHVSGEAPNSSSDLAGKSLKQHDEVISMVVDAEMSMAVGEHLPKFYASPDSVAADTVMPTSYKVATDGLGPIIPGDDINFISREDYAEVVDICDVVNTPSNTTKDAVSPWENPSYVGPRYLAAPNSRNTRVKPSGVRRGNVARCAMTYPFQDNEDCEILKAEISPDTFQDIRKDPILYVVNCCHNQTFQDHCGVIVSFLNDFFKYSMQNRRSLADKDMDGLNKDEWITSTKFRKYVYASSGIKMKHRMFSFPSDAFFNSLFNPNILQGLSKPTDSCPTKLTRADRQLLIRLDGMLKELSDVEQSAKSVAESLQAGALSRSGKFVAYWQKHFTSSGTPLISSKATSEAVSSMPTSIGIASKVSPAVPPSSILEEAEAEIAKLPLRSQVQPMAETVAEGLCNIVKPAEDDLYDLIKPIHIDNHINAVEKLHRAVTVVLQSSDTIHAFTYSDFIDDYLDAIWETLEDNLSKCRVQRRSEGSATSSQAEPAEEVPDVNLDTNVLLSRDLPTKDAFKKWLHLLTLYTESILVIKLSLIRLQGKSIPVKDPKISLMSINVVTWKQPNSSMMNLKNVLEKLLDNEGRLQADDKKFYSMDQLVTFVNDAFTTMQADRMNNRKKLPLQSTNKDEGLRGSTEFDMRFKGRVHCEGALGSLLFPPSDFQDYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWJ3</accession>
    <name>A0A401GWJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0904760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617510.1">
        <property type="nucleotide sequence ID" value="XM_027761709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWJ3"/>
    <dbReference type="GeneID" id="38783514"/>
    <dbReference type="InParanoid" id="A0A401GWJ3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="145" mass="15704" checksum="D1A3C8827BBAD2F3" modified="2019-05-08" version="1">MPSRVLGITRLALEAVLPAEFEPSDLALADDEDVDCDASDTNESLEAGDAGDNTTDTDSGMDVSDKKFCVRDSTGFDIPLQPLELPDVHDFGDREDPIVLASTVCEEDIRQALAQVASVAPPGHCVMQDKTDWVRTLARIPPSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWJ8</accession>
    <name>A0A401GWJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0904770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617511.1">
        <property type="nucleotide sequence ID" value="XM_027761710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWJ8"/>
    <dbReference type="STRING" id="139825.A0A401GWJ8"/>
    <dbReference type="GeneID" id="38783515"/>
    <dbReference type="InParanoid" id="A0A401GWJ8"/>
    <dbReference type="OrthoDB" id="3227833at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="192" mass="20544" checksum="C1287D6A4DC0890C" modified="2019-05-08" version="1">MKTCKVARHVCFVNGIEANTYLSDAYLETTFEILWRLWKAAGGPIVKGKSKAVPPSDAHTMSTTGIPESSAATQTSGVSASADNAQSSPRTSSPVNDSVPSNLSGTGKPETDTRDSDPSTYLNLLNRDELFEWMIDRKLAGNVKLGKKSSSMKKDKLVSIILSAEATGQPSKAEVETIVQQHKVKKMAASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWS1</accession>
    <name>A0A401GWS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0904980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617532.1">
        <property type="nucleotide sequence ID" value="XM_027761731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWS1"/>
    <dbReference type="STRING" id="139825.A0A401GWS1"/>
    <dbReference type="GeneID" id="38783536"/>
    <dbReference type="InParanoid" id="A0A401GWS1"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE86619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="675" mass="72589" checksum="3CE970D22FD5D236" modified="2019-05-08" version="1">MVSYNITREVERLLETYKSSPPSFIVKLERQHWYVNENKFTYNHQLAPLLDDIRAQRIPVDFLELFDSVGLPFYDGCMIVELHDFRSPTRASDKDIKEPVKTRVVLSPNGETLWADICLLNQKTGNTWTGYDALEVEARLLLATSPPLCLDPDPHLARVANNILRTSIPTPPLSLKRKAGAAELEEDPSGKARREKLMQYMNPRTGNGVPNYGILDAIRRTNMARQIPAAAPPHPATIPTMPVQVPGAPVQVQGVPVQAPGVPVQMAVAPSQVPTAVPTPAPAPMPTPTPTPAPSLAPGSAAFSHTTPVSASTPAPTVTTPPVNVEAKKKAKKTEAAPSPRVTRTSATPGTTSVPLPIPPHLQTYPAHFQAHIRTPPPPSQSPHPATPSTPGRSSTGVETRPPSRLQQLPTQTNQHIQPVQPQQHAAPTQPQQAIAAYQPHTPAANYIAQAPYGKKKAAQAAQPGTVPSQPQAIPYAQIMYHYSTYQHQQQQVAAAQQRLQSATPVARSPMAASQQGTPQRSSPLVTNQPPVARSPMPTAAQQSAQATHAQQQHMYNYALQGQYGPAAHMRPMAHPQMQHHIAGGGVQAGGATALQQGAQMTIQEQTQAAQAQMLAQYPQLYANYPHMQGRVPYWPMGVASGRGAPVPNQAAQMAHVQQMQLAGNKAAQGGIQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWW0</accession>
    <name>A0A401GWW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo-keto reductase dtxS3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0905960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617629.1">
        <property type="nucleotide sequence ID" value="XM_027761828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWW0"/>
    <dbReference type="STRING" id="139825.A0A401GWW0"/>
    <dbReference type="GeneID" id="38783633"/>
    <dbReference type="InParanoid" id="A0A401GWW0"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE86716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="345" mass="38385" checksum="8DD8D5904E78C20A" modified="2019-05-08" version="1">MSSTLKMVEYRQLGKSGLRVSVPILGAMSFGSSEWAPWVINEDRAIPLLKAAWDRGVTTIDTANVYSNGESERIVAKFIAQYNIPREELIIATKCHGLVAKDVGVRTSINPQLRSLPQYVNQSGLSRGAIFKQVEASLKRLNTTYIDLLQIHRFDDTVPVEETMKALHDLVESGKVRYIGASSMRCWQFAMMNEVADKRGWTKFVSMQDEYSLLYREEEREMIAYCNFNGIGLIPWAPLAAGALARPLGSETTRSEAAKGTVFENKIKASDKVIISRVEELAKKKGVAMAQIGLAWIQTKVTSPIVGCSSVSRLEEAIVQGVDLTPEEIAYLEEPYEPRPIRGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GWZ1</accession>
    <name>A0A401GWZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Casein kinase II subunit alpha</fullName>
            <shortName evidence="10">CK II alpha</shortName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0905820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000009">
        <property type="protein sequence ID" value="GBE86702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617615.1">
        <property type="nucleotide sequence ID" value="XM_027761814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GWZ1"/>
    <dbReference type="STRING" id="139825.A0A401GWZ1"/>
    <dbReference type="GeneID" id="38783619"/>
    <dbReference type="InParanoid" id="A0A401GWZ1"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE86702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="340" mass="39589" checksum="781EBD8D09F4B947" modified="2019-05-08" version="1">MARVYADVNALLGPAWFDYERITIDWNVPDRYELVRRIGGGKYSDVFEGLDSSNEDKCVVKVLKPVAKKKIKREIKILRNLSGGPNIVGLLDVVHDPPSRSKSLVMEYVENVEWKELYSVLTEMEIKHYLFQLLKALDFVHSRGIMHRDVKPGNIMYDRECQKLRLIDWGLAEFYHPGTEYHPRVGSRYYKAPELLVNNRLYDYSLDMWSVGCILAAMIFRREHFFRGRDNEDQLLKILKVLGSANFEQYLNTYALYMQAENDDLLSSYSKQPWTRFVTADNRALVSHDSLDLLDRLLRYDHQERLTAAEAQSHAYFNIVRLQIPSNPAECPSDSGFYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXL1</accession>
    <name>A0A401GXL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1001660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE86922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617835.1">
        <property type="nucleotide sequence ID" value="XM_027762034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXL1"/>
    <dbReference type="STRING" id="139825.A0A401GXL1"/>
    <dbReference type="GeneID" id="38783839"/>
    <dbReference type="InParanoid" id="A0A401GXL1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE86922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="234" mass="26143" checksum="D4DD3AFCD4F4B80F" modified="2019-05-08" version="1">MPEIITLYTAKVCPYAQRAELALEEAKADYTKFEIDLSNKPEWYAPLVNPASKVPAIAYGGPKVPPEQPSPKSVKIAESLIIVEFVADLFPEANLLPKDPVLRAKARFFVDAVSTKFTPTWFPFVAGKGSAEDFIKGTEQVQALLPESGFAIGQYSIADIAITPFLARAELLLRHAIGAYSAEEAKKVYETVWLSPKFSRLQKYWNDVKARPNFKASFDEEYVKGVFETRFAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GXW3</accession>
    <name>A0A401GXW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pheromone B alpha 3 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">SCP_1002940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617960.1">
        <property type="nucleotide sequence ID" value="XM_027762159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GXW3"/>
    <dbReference type="FunCoup" id="A0A401GXW3">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="GeneID" id="38783964"/>
    <dbReference type="InParanoid" id="A0A401GXW3"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="GBE87047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37088" checksum="D9B160F215E87086" modified="2019-05-08" version="1">MNSILWRDTVVNFAPVWCDISSRIIVASAVAIPAASLCINRRLYCIATIKSVSLSWAEKRRAVIIDLTIGLGIPLLQLICQYVVSGHRFDIFEGIGCYPYTYNTIAAYPLSVLWPLVIGLISAVYCVLTLREFFRRRAEFAEYLSANPSLTTNRYFRLMALASVELLCTVPISSYGLYLNLSAAPLSPWISWSNVHYDYSQVDQYPAVVWRTSRNSLVAFGLSTWAVPFCAFVFFGFFGFADEARKNYRKTFLFISRLCDVGSHKRLADRPSAKFGGSVRVGCNLASTPFPRCPPPVLHLSLTPSIDSAEKTDLAMEASVAQVEPSDSRPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYI5</accession>
    <name>A0A401GYI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Non-histone chromosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1003310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027617997.1">
        <property type="nucleotide sequence ID" value="XM_027762196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYI5"/>
    <dbReference type="FunCoup" id="A0A401GYI5">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GYI5"/>
    <dbReference type="GeneID" id="38784001"/>
    <dbReference type="InParanoid" id="A0A401GYI5"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE87084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="118" mass="13180" checksum="7E15BC8963809936" modified="2019-05-08" version="1">MPKESTKSSKRKAVDKAEKAPKAKAKRDPKAPKRALSAYMFFSQDWRERIKAENPDAGFGEIGKLLGAKWKELDDSEKKPYIEQAARDKARAEQEKSEYDNKKADSAGSGDGGDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYK8</accession>
    <name>A0A401GYK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1004950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618161.1">
        <property type="nucleotide sequence ID" value="XM_027762360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYK8"/>
    <dbReference type="GeneID" id="38784165"/>
    <dbReference type="InParanoid" id="A0A401GYK8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE87248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="108" mass="11859" checksum="F2C4D0D93A182C7A" modified="2019-05-08" version="1">MREWCVEGNDSAVIGKPTCNIQYLAEMNTAAVAIAYTSWSFHPTPQVPRTARKDHRPSDSPYVTFASPWLSNLRKSVPVSSIALSVHGIGSPNTSTLEYHLLGVEMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYQ3</accession>
    <name>A0A401GYQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_1005450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618210.1">
        <property type="nucleotide sequence ID" value="XM_027762409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYQ3"/>
    <dbReference type="STRING" id="139825.A0A401GYQ3"/>
    <dbReference type="GeneID" id="38784214"/>
    <dbReference type="InParanoid" id="A0A401GYQ3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE87297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="424" mass="46317" checksum="AD7CF197DF99A8D4" modified="2019-05-08" version="1">MQRGSAGFTVTAEMEAILRHPGYISCDAGGQRLRDLYQSQSAAFDYNLYNPFARCCFLGLIRNVSRMVERGEAPDLTGTETPYKFGYLTIAVTGCVMNMTPPPVCDYVSVVKCLLSSGAPPNSEDIVGYSALHHAAMNNGHRDNPILLELMRILLKNGANANHQNRYGEVPISGAFQHEEIGAIDILMEYGADLEMADADGVKPNPFFIKCGAKVTAAVTKWLRKRTGEEAPMGDTKMCSRCGRKGGSLKMCAKCHVARYCSTECQHAHWSTHKLTCQPFDASNTVTVRPSYSAPGTMMSTADFSRQALGIPTEPTPASHQRAARAPKLRPEEAKAMIIKVQVPYSVLADSPSTISRADMLVYTKKRDFVCNIKHSGNAAAYSRISQVVRSRGVGGAKAYFPAELKGKYELIIKIGEVLAEQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GYQ4</accession>
    <name>A0A401GYQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspyridones efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_1005380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000010">
        <property type="protein sequence ID" value="GBE87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618203.1">
        <property type="nucleotide sequence ID" value="XM_027762402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GYQ4"/>
    <dbReference type="GeneID" id="38784207"/>
    <dbReference type="InParanoid" id="A0A401GYQ4"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="73"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="471" mass="50349" checksum="5295C2B00F244151" modified="2019-05-08" version="1">MESRSDFARNGAPAPPEGIAEATIKSEHASEKDCDDKKEADEEEPVKGKDEEVPTSTAQATDFPEGGWRGWGTVAGAFLIQFCGFGYTGSFGVYQAYYVQTYLANESASAISWIGGMNAFLVISSGLVTGRLYDKGYFYYLLIGGSILYSFSLFMLSLAQPDHYYQVFLCQGLGMGLGAGTVYVSSVAVVSHYFVKWRALAMTIVASGSSLGAVIHPIMLNNTLNGWLGFGNAVRASAGLVTGLLLIACLLMRPRLPPSKHTITIAQAARKFSRDPAYIFATIGLSLFTIAFYYPLFYIQLDASVHGLSSTFSFYSLVILNSASFVGRLAPGFLAHSFGVANMITIAVLGCSILLFVMIAVKSVASVVVVGIIYGFFAGNYITLMAPLMAVLSDNMSELGVRMGLAFAFSGIGGLVGGAISGALLTSKYIWWRPAVFSGALGMFATASFAAMTFCLARKARTAKRRPEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZ17</accession>
    <name>A0A401GZ17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_1100840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618321.1">
        <property type="nucleotide sequence ID" value="XM_027762520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZ17"/>
    <dbReference type="FunCoup" id="A0A401GZ17">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZ17"/>
    <dbReference type="GeneID" id="38784325"/>
    <dbReference type="InParanoid" id="A0A401GZ17"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024586">
        <property type="entry name" value="DnaJ-like_C11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055225">
        <property type="entry name" value="DNAJC11-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052243">
        <property type="entry name" value="Mito_inner_membrane_organizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44157:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11875">
        <property type="entry name" value="DnaJ-like_C11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22774">
        <property type="entry name" value="DNAJC11_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE87408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="599" mass="67147" checksum="DB7F3DC065F1D823" modified="2019-05-08" version="1">MPDTSPDLLNIPGSPNDREFLYAVLNLPTTASDNEIRERYKQLSVVFHPDKQHDGQAKDTATKRFLEVQKAYEVLSDPITRRAYDLLGPDGLKDVQLADLSGLSKEELDAALIHNNIEVERARLEPIVRPRAHISLNVDASSLFEDDDYFNAKDEPLHGRLTRRLKEVQRSNLTFRHTVQKEINDKTVLVLSSSGGGTSRGKIMGTIRHQYSPRWNFEATTSLLNMASLGLKTTYRDDDSTVMVQTHLPALFRRFFSSLPEDRRLPPFTVALSRRLFPESPTQGTIVVTTRSPMPVVSVNLSSAHFFDHTPEASIPMPNLGSEHGVRPPSVHGLALGTTFWNVGVTMAGLMTGVSAQWGLNFVELGLQAKVIAQFALNGWSWLVGCEWRKNDSAAGASVGMGLEGIVLKLDVFYLGQQLTVPITLSHDRELGLALWTTVVPSTALVAAYYFILRPRRRRQRMEFFRRARRDLRDEKSDVLREIKETSHLLQDTAKKHMQAEASCGGLIIVEALYGPSERDESTKGLDVDVTVPVQALVNKSQLYIPGRRSKAGLQGFYDPAAMVAKTLRIRYTFRGRLHYAEFTDHMPVVLPLEEHLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GZM6</accession>
    <name>A0A401GZM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein P1-alpha 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1102660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000011">
        <property type="protein sequence ID" value="GBE87589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027618502.1">
        <property type="nucleotide sequence ID" value="XM_027762701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GZM6"/>
    <dbReference type="FunCoup" id="A0A401GZM6">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GZM6"/>
    <dbReference type="GeneID" id="38784506"/>
    <dbReference type="InParanoid" id="A0A401GZM6"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE87589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="110" mass="11070" checksum="0E51973E98DBA7FE" modified="2019-05-08" version="1">MASLELAATYAALILADDGVEITSDKIIALTNAASVELEPIWASLLAKALEGKDVRELLSNVGAGGGAPAVGAAPGAAAGGAPAAEAPKEEEKEEKEEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H187</accession>
    <name>A0A401H187_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619062.1">
        <property type="nucleotide sequence ID" value="XM_027763261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H187"/>
    <dbReference type="STRING" id="139825.A0A401H187"/>
    <dbReference type="GeneID" id="38785066"/>
    <dbReference type="InParanoid" id="A0A401H187"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="84175" checksum="4D005333FA7590AF" modified="2019-05-08" version="1">MMLSMRLLSLNDDVLLLVASFLHPLDARRLSETCRHLHLIALPQALSAIVLGTCFQLAAFCRYMLSSPQTPMDLLRVLVIVAPVGDVSNAALLADVFEQALRLRSIHMHHSDTFIEAEPRISTTLAALEDLEDVTLFNARELVREMLLRLRSKPRKVQLLCPMEYPRLVLHLSQLSALRHAVTLSLFNITIEDDTLVGQPAAPFVALQHLSLHYAQIPAVLFPFPNLDRVEVWLGEILGPTPDAVLSPTPRTVRNVSLDASWMRIATTEEDIGQALRVLQFVQPLTLSLKIFVRPLLAFWTCLVALSPQLRYLDLELDTMRVLENGVRVFSFVTEWLRVISPLLASLNLHCLRVSVAHSRTSLRQQIQDILLQHVGPSLRYIGVSRDPATHAGSWRCPSRLVRPFTKLYALQLRIKFDVYDTDLLSRWFCDNSLTSDVYSIVNENCLQWDSGGSKKLQCVKGRSTAAKAASGIYALIVTCSLWAFSKWWWWFIAAVVLHGGRAEHQQHGDIDSAASLRDDELNLSVSTHLGKSTWDNLGLRTRATTSLTIESPYSTPSVAPLHPIYFLAIHVFASVTDLRLFHVEFRTFLDFARLVSSFPNLLAVEFWNVSWLEHGSNPFALDCYRSRFQWNDLVIDDVELTGLAQLLRAVGSSLQHLTFRADNEWMESFVSEEGLSMVHLTSLRSLQIPIRLDRTDFGSIEELLSRHICSRVMCSLTFSFHYGYNATPLDGAKDVLLRMERAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H194</accession>
    <name>A0A401H194_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1203800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000012">
        <property type="protein sequence ID" value="GBE88150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619063.1">
        <property type="nucleotide sequence ID" value="XM_027763262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H194"/>
    <dbReference type="GeneID" id="38785067"/>
    <dbReference type="InParanoid" id="A0A401H194"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="274" mass="30510" checksum="C094DED0B80AECF8" modified="2019-05-08" version="1">MQKRILVSRVTAYELWTSFRQTHPWTAHVILEWTTGTAHMRMRIKRCLMRSRVCIICREIDGAECGRSARDLGFPLFHDPYILCEQSMSDSMANMADVSVQSPFVQQEHALPGRAVPSSHNEGLSIPAHGAPWITELDDQTFLDHDQLDPLSERLLASSTMMYHDLHYPYQPSSSHVQAPAARGPEHLSLCHAPPVGIVVLSDFGVCEESPRFRTPYSQPFPHKMTDSPLTTMGLPRGGGKMGNCAIRHLALATLAGALRHPAVIESQPVVEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1J3</accession>
    <name>A0A401H1J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1300930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619191.1">
        <property type="nucleotide sequence ID" value="XM_027763390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1J3"/>
    <dbReference type="GeneID" id="38785195"/>
    <dbReference type="InParanoid" id="A0A401H1J3"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="195" mass="22154" checksum="B388F3A287B861AE" modified="2019-05-08" version="1">MYDYGPLPGSGFSEVIVQLDREGYLDLIKCAEILSVAKVTARRKLEHLHDGILPADLIESYAEVSNGVPVIALAEYPPLCQYDARSNTFHTPQMMRPLQPCGNCTWRKRYLYAGELPAVMDPDGFLAVTSMDVGLDLDVKPPRSGLHYWLDIFHAWTSTPPEQRMDWSRPIASIFMITYDLAQENRTQRYAVIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1V3</accession>
    <name>A0A401H1V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1301870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619285.1">
        <property type="nucleotide sequence ID" value="XM_027763484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H1V3"/>
    <dbReference type="STRING" id="139825.A0A401H1V3"/>
    <dbReference type="GeneID" id="38785289"/>
    <dbReference type="InParanoid" id="A0A401H1V3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="325"/>
            <end position="342"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="30"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="575" mass="63716" checksum="50DA5C1BBEB586C3" modified="2019-05-08" version="1">MVRPPEWTIVDLVYRGYWWKNPRIRVLNFLLLIPLLSASMNGFDSSLVNGLQILPAWQTYFKHPDGKKLGLMCAAQVIGSIAGLPLTPFSSDILGRRPTLLIGSVVMLAGVALQSASMSIGMFIGARGLIGFGLTFSLNASPLLITELAYPTQRGKLTSIFNASWYVGSIISAWTCFGALEGAVGSAWSWRVPTLVQALVPVIQLCLAWLVPESPRFLVARGRESEAARILARFHAMETGDQRDLLVVFEMAQIRHALKLEKEAAKSTSYITLLATPGNRKRMLIVVALAVFSQWSGNGLVSYYINLVLKGVGITNAGTEAAINGGLQVWNLIAAMTGALLVDRLGRRALFIISNIGMLINFGIWTLTTALWDMRNNSPAAKATIPFVFLFYFFYDIAYTPMLISYTLEILPFSIRAKGFAVMNFLVSLTTAFNQFVNPWALDALGWKYYLVYCGWLIVELVFVLTYIVETRGHTLEETAALFDGEQQPQELMQTGEEAATIMSMDRARGESVWRDAGWRGAQLRDIDEVSSDGDSVVDWRIGEKSAPANLLELRTMKPGRKIYNPYRNSDCTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H1Z1</accession>
    <name>A0A401H1Z1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">J protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1302660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_027763563.1"/>
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    <dbReference type="GeneID" id="38785368"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
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        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="518"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE88451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="561" mass="63377" checksum="846C57A917257D40" modified="2019-05-08" version="1">MGNGESTAGGAPAEQGIAEPGVPDYYALLDVDESATADEIKRSFRKLALLHHPDKNQEDIEGATKRFAAIQQAYEVLSDEQERAWYDSHRASLLPEPDAQTVFEDIKTGAPPPRARDRGLTVRHLAQFFNTTIYEGFDDGKDSFYTLYRNLFDRLAHDECQWIDVPFPSFGYSTWPWVPVSKGQQDKAARTFYNYWMNFVTNKDFTWMEAWNVSEAPDRRVRRLMERDNKKARDDARKEYNDTVRSLVMFIRKRDPRYKAHLARQSQTSTPGTRTPVSRPATQQVPPEQQFVEQEWQKAAREDDAADLEWAAAEGTEDPEEWECVACGKSFRSEAAWDSHERSKKHLKAVEMLRKQMQEDDEELGLHVEGEEDLEADEAENGDNDLGDTLLDEVAAEEPPRSPTPTVTHEADDVNDDDAEEKVACPSKSPRKGKKTSSPDVPLKTEGRTKSRSQGQASNAPEGLPVESGQRLKPSQDDEAADSSEGQTNPQPEPSKREKRRAKEAEKKARGDNITAKLRCNICNSQFDSRTKLFAHIKATDHASAVQDVDMRGKKGKSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H200</accession>
    <name>A0A401H200_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1302820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619380.1">
        <property type="nucleotide sequence ID" value="XM_027763579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H200"/>
    <dbReference type="GeneID" id="38785384"/>
    <dbReference type="InParanoid" id="A0A401H200"/>
    <dbReference type="OrthoDB" id="2660310at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="101" mass="11682" checksum="2DFD4CF3526F9C21" modified="2019-05-08" version="1">MLSDELGRHGWDTAKYDKFLKDIGDLAVKYLELDKTISKQKQTMLDAVYALAMKLYPQLAHYKKCWPVRDVLKTKLGNMTYMTKKDRKEQEAHASVAPAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2A9</accession>
    <name>A0A401H2A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1303450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619442.1">
        <property type="nucleotide sequence ID" value="XM_027763641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2A9"/>
    <dbReference type="GeneID" id="38785446"/>
    <dbReference type="InParanoid" id="A0A401H2A9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE88529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="75" mass="8163" checksum="8F88BDE62E3721D1" modified="2019-05-08" version="1">MTQGCCHDIFFRAGCHSCGLNILSMDLASSSTPRILEYAMWLRDASPTAPIFGPTSQPNFLSGIVDKDMLLHSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2D2</accession>
    <name>A0A401H2D2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1303360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000013">
        <property type="protein sequence ID" value="GBE88520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619433.1">
        <property type="nucleotide sequence ID" value="XM_027763632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2D2"/>
    <dbReference type="FunCoup" id="A0A401H2D2">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="GeneID" id="38785437"/>
    <dbReference type="InParanoid" id="A0A401H2D2"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE88520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40463" checksum="895F59F75865927C" modified="2019-05-08" version="1">MTALDLIQQGITPSFEWPVKFGLYTTAVAYVLSVITGNVSQVDRIWTFMPTIYTAYFALLPLWSHVSPLPLWPYKPEVLDSHVAVNYSQRALLMFALVFIWMSRLSYNTWRRGLFNLHDEDYRWAIVRKNVPSRFLFEIFNLVFIAAMQNVILFLLGLPTHIAAFQQPTELSTSDYVLGSLALLDLALEFVADNQQYSFQTFKHNGVLEKNDWPGARIQWTEEDAKRGFITRGLWAWSRHPNFFFEQTFWAIITLFPLLAPETPSLPTLPITSMAPLWPLTPAFVLCSLFISSTSFTESISSPKYPAYRAYQRRVAMFVPFLTPVWGLFLKVRGKKEEVDELLFGKGKKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2R2</accession>
    <name>A0A401H2R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_1401300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619638.1">
        <property type="nucleotide sequence ID" value="XM_027763837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2R2"/>
    <dbReference type="STRING" id="139825.A0A401H2R2"/>
    <dbReference type="GeneID" id="38785642"/>
    <dbReference type="InParanoid" id="A0A401H2R2"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE88725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="272" mass="30411" checksum="289584BB2291CB57" modified="2019-05-08" version="1">MSPPEKKQKTDSYTLYYWPGIPGRGEYIRLAFEYAGVPYTEKLNGNTLMSTLRNPSKIGHPPHFAPPALELPSGKVISQTTAILNHIAPKLGLAGELGSKLAGEEQLSAEDRERAEEERSTVNQLVLTGMDLCVEAHDVHHPIASSKYYEEQKDAALERSESFRAERMPAFLTHFEKVLSTNPATMDSERTFLVGAKTTTADLVLFHVVDGLLFAFPRRMAVLKKSGKYDDVFALHERVAGEEGIKEYIASGRRKKFSNGLFRHYPELDGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H2U0</accession>
    <name>A0A401H2U0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_1401600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619668.1">
        <property type="nucleotide sequence ID" value="XM_027763867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H2U0"/>
    <dbReference type="FunCoup" id="A0A401H2U0">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="GeneID" id="38785672"/>
    <dbReference type="InParanoid" id="A0A401H2U0"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="295"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE88755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="565" mass="62457" checksum="79186630400678FD" modified="2019-05-08" version="1">MSKPTDTRPPVITPKGHRPRPTRSLSTTAPRVPTRRPSVTGLSLTGTLNPVTGAPKAQRTSKTIQKLVLLPSAPQTKPLPIETEEEEELLGYERDRGVREHKSAGERMSKEQREKAGFRRITAYCVAEGFKMKLLASFLKREHNVHPRVFDEAMYVMYHFPLLPAYGPNLNIRSSAPPAQSDGAEDPEAGFSEVEEDWYQGSYFKPSSSPTAAAPAMGGFIPSTSPIVTGADLVGATEIEVVPETSANADLSVDVQPKVQQDVREQRVFRRKRGDGRAGRKSSTAASTEDFAEAIFFEYGVVVFFGFSEEQERGILEDVEAAGALRRKLVEADWEIEQCHYAHNPDIAYPRIYNDFFTFKTYSHLLKLSVAHAFAQSTLLAHYETHAHRILSSQDTTSIPQQLASTGVLRLSRKEALKLTGRLFTLRRDVNLVSNVLDVPELFWSEASLNALYDAVREYMEIGGRVQVLNEKLAVAEDLLGAIHDHLNNNAMDRITWIIIWLIVVACAVELGEILARLVVHATMGDSVPVEVPVCTGAVAALSALSREEALRTLELIAGINTDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3G7</accession>
    <name>A0A401H3G7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_1403930</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="BFAD01000014">
        <property type="protein sequence ID" value="GBE88985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619898.1">
        <property type="nucleotide sequence ID" value="XM_027764097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3G7"/>
    <dbReference type="STRING" id="139825.A0A401H3G7"/>
    <dbReference type="GeneID" id="38785902"/>
    <dbReference type="InParanoid" id="A0A401H3G7"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="16">
        <location>
            <begin position="262"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="633"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="GBE88985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="674" mass="73422" checksum="0E110181616DC9AB" modified="2019-05-08" version="1">MKLVRGSDGAPEHKYNGSRTLLVIVRGMLPTTRLFALVALGLSALLVSASVSPRVIHESRRSVPAGWRPVRRAEPSTVLPLRIGLSQSNLDNLEALLLDVSHPESPNFGKHWSAKQVADTFRPSQETIDTVRAWLVESGLDAERIKLTKGGSWIQADVTIAEAEVLLGTEYYIYQFGEEEGGREHVACAERYHLPEHVSKHVELITSTLHFDVKHKRETHRFEKRGPETAKSIGQPGFGASFPKTTGTIQQIFTELEECDKQITPDCLRALYEFEYIPLAADKNSIAIVEYTPQAYTAADLDMFFGNFSPSQVGERPYMVSIDGGYVQTEYTGFNYNGESNLDIQYSMSLVGPEQTVTLYQTGDMVEGASLNNLVDALDASYCTFEGGDDPTQDGIYPDPYGGGYEGPESCGIVTPAYVMSTSYSYDEADLTPFYMERQCTEYAKLGLMGMTILYSSGDYGVAGYNNTCLYPNGTQAVGAPIFSPTFPSTCPYITSVGATQVNPNSTVLEPESACEQVIYSSGGFSNVFAMPSYQKTAVESYLANYPPPYPADIWNSTGTSRAFPDISANGANYVVAIQSEYMLVYGTSCSSPVSAAILSAVNDARLAVGKGPMGFINPTIYTSRGMEAFNDITTGTNPGCGTVGFYAERGWDPVTGLGTPNYPRLLELFLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3L7</accession>
    <name>A0A401H3L7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1500040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619915.1">
        <property type="nucleotide sequence ID" value="XM_027764114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3L7"/>
    <dbReference type="GeneID" id="38785919"/>
    <dbReference type="InParanoid" id="A0A401H3L7"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="316" mass="34992" checksum="0D58C90588FF1411" modified="2019-05-08" version="1">MQADECILFFAILAPPTFSPASASQPPEPAIHLIKMSNLLPMPLTDQIAGVLELMFRRKLHLATHAAHSAPSIEVPPSMPSALLLECNGIADALVKAIRNSVRLQWDIDRYCDSLSIQPTGQNEVLEAELERKWPPPFGESEIRIDQPATLVDMHGRILAWILPRVLIPDRQMKMVQATRALHPAIAASKPSSTTASWRHNPLYFLPPEECAQFPAGSLCLSPGWFQQVREHMESGRLETSASLKLEGGRSWLHDIHDSSALLGAILAVVHPTLYAAGRQCLGLIQQDPELREMALNWSSPFNALQVIANRETPFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3M0</accession>
    <name>A0A401H3M0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1500290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027619940.1">
        <property type="nucleotide sequence ID" value="XM_027764139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3M0"/>
    <dbReference type="GeneID" id="38785944"/>
    <dbReference type="InParanoid" id="A0A401H3M0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="70" mass="7834" checksum="AADAF5C286AB898C" modified="2019-05-08" version="1">MLFVAVNVATIFEKTTTSSYSEVPQESHLFDIGPPSVTYFLESHRTPSYQGTRFPGTAFCIAMKYSDSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H3Z7</accession>
    <name>A0A401H3Z7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1501120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620022.1">
        <property type="nucleotide sequence ID" value="XM_027764221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H3Z7"/>
    <dbReference type="STRING" id="139825.A0A401H3Z7"/>
    <dbReference type="GeneID" id="38786026"/>
    <dbReference type="InParanoid" id="A0A401H3Z7"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27566" checksum="07F53C6ABA3D99F9" modified="2019-05-08" version="1">MALTSKCVIREVVKDVWTFSCPFSRFGVIPFGGRSTAVKLHNGDVWLLASTPLDGETKSKLAEIGPVKWIIGADRVHYLYLAEFKKEYPDAKLIAVEEVKNAKEKEGLEFHGAWGADPPDTKYGFEDDIEHCYFSGHINKDVAFFHPASKTLMEADLLFNLPAIEQYSKTGSSGRLPIFGTLKPDTWLHKKFAWMTGQDKEAMKRDVKTVAGWNFERIIPCHGDVIEKDGNAAWRQAFQWYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4A3</accession>
    <name>A0A401H4A3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">SCP_1502520</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
    <dbReference type="EMBL" id="BFAD01000015">
        <property type="protein sequence ID" value="GBE89244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620157.1">
        <property type="nucleotide sequence ID" value="XM_027764356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4A3"/>
    <dbReference type="STRING" id="139825.A0A401H4A3"/>
    <dbReference type="GeneID" id="38786161"/>
    <dbReference type="InParanoid" id="A0A401H4A3"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="148"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="369"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="685"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="758"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="GBE89244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="824" mass="92535" checksum="C4F826BD91A4A75E" modified="2019-05-08" version="1">MPWYPSDEIDGVLEMSRAEYMATQGNHSLNADAGPSQTRRTASSSHPRRMTSDIGIINAGIAEIDEEMERLKARRASLIVQKQTAEKNKRKLDASIRNISALRVKDTGRVSEKGIDYTTEFEWTGPLRYKMKMVFGIDDFRLCQQGVCNANMDGRDIICVMPTGGGKSLTYQLPALLSNGCTLVISPLIALMEDQVLHLKEVGVRAAMVTAELPRAEMDQITRQMKIMASSTETDRSDIKLLYVTPEKVVNNRNFLSLLQALAEAGKLNRWVLDEAHCISHYGHDFRPDYQRLTILRTTFPNVPIIALSATCPPAVLEDIRKVMKMGPIVNGSSAPPVGTVYFSAPLYRKNLHYAVLPKPSTCSAAITMMKNYILEHHKNHVGIIYCLAKKDAEDVAQKLKEESGQEIKTEVYHSDITRDAKEAIHKKWREGQVKVVCATLAFGLGIDKSDVRFVLHHSMPKSLDGLYQESGRAGRDRKDADCVLYYRPQDAIRLTQIVDKGAGELDKLHDMLRFAQDVEQCRKIQFAKYFNSSADLSMDVWTTGDEDAETPCGHCDNCTRSAELVDRRDITLAAWRVLKVVEIVNKRGGFVTVAQLADLVRGHGGSSFHAKVKKGRKTVREKVHLDLNEVAGGKLEYSKQDAELLCIHLMVEDYLKTFYSVNNFTTNTYVRLGNNADRLTQLSKQDVEQGKTPAIHRSFLIKSKRKPTSRRIGETTSNRQHEDGPSSSRKGKRRAIEFSDGEESDDESETARDSDFISASTSEKPRSSYSYRPSEGKAPHDEDVWSRSMLSPPPRPSKRPRRTCRIPDMDRTVDVEVICISSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4P9</accession>
    <name>A0A401H4P9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-directed RNA polymerase II subunit rpb7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_1600680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620320.1">
        <property type="nucleotide sequence ID" value="XM_027764519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4P9"/>
    <dbReference type="FunCoup" id="A0A401H4P9">
        <property type="interactions" value="511"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401H4P9"/>
    <dbReference type="GeneID" id="38786324"/>
    <dbReference type="InParanoid" id="A0A401H4P9"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE89407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="170" mass="18879" checksum="FEAF8E8A1CAB3741" modified="2019-05-08" version="1">MFFIKELSHTILLHPSYFGPRMLQFLESKLYADVEGTCSGQFGYIIAVVSILDIGKGMVLSGSGQAEFITRYRAIVFKPFKGEVVDGVVNNVNKMGFFADVGPLVVFVSHQLIHPEMKFQPNSNPPSFASQDQIIEKNTRVRLKIVGTRVDATEIFAIGTIKEDHLGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H4Z7</accession>
    <name>A0A401H4Z7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1601560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620407.1">
        <property type="nucleotide sequence ID" value="XM_027764606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H4Z7"/>
    <dbReference type="STRING" id="139825.A0A401H4Z7"/>
    <dbReference type="GeneID" id="38786411"/>
    <dbReference type="InParanoid" id="A0A401H4Z7"/>
    <dbReference type="OrthoDB" id="2801991at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="249" mass="28738" checksum="9D9105A1B9E40073" modified="2019-05-08" version="1">MVTGITGLPVLGMKGSPKKFKGSYAEVARFLQHYEWLCAQLNIVTAEDQVENVMQYCARSVRQFMESLSAYVTPDWNAFKRDVLTFYDADRDKRQYKVKDLEALVKESHRKPTIKNLGAWWEYSRNFLTVAGWLVNCGRISEVEQSLYFWKGVPRAFRQDLEPCLLAADPNHDMFIPFSMSSIRMKAKTILQCNRFHQDQLPSEDEDSSDDSDDADSDDDSSDSEDSSSAEETHRQKCKDKKKKQSMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H5B9</accession>
    <name>A0A401H5B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1603010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000016">
        <property type="protein sequence ID" value="GBE89637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620550.1">
        <property type="nucleotide sequence ID" value="XM_027764749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H5B9"/>
    <dbReference type="GeneID" id="38786554"/>
    <dbReference type="InParanoid" id="A0A401H5B9"/>
    <dbReference type="OrthoDB" id="3002933at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="211" mass="23706" checksum="DC39B7DB9BA06913" modified="2019-05-08" version="1">MPYAQAGRLRYTKALLWRLSIKATAFERLSVVIHQLLRNLQISSLPPSVPLIMSLPPPCFTPGSLYLAGFAQARGPHAALIIPFSPSAGRLVHIRIDYERSQTWVYQSKLQEITGDMFLSTLIKLRDVSLGHVTVEQLEHAAAYVPLPPNDHHGECLPWALGVVRKLQEMGLLNVSDVHQLGEEFVQFSAGNWLYATRHRFPNVKESQFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H698</accession>
    <name>A0A401H698_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1702940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620881.1">
        <property type="nucleotide sequence ID" value="XM_027765080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H698"/>
    <dbReference type="GeneID" id="38786885"/>
    <dbReference type="InParanoid" id="A0A401H698"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="357" mass="36407" checksum="46FB093E366A8648" modified="2019-05-08" version="1">MTESGVTAELSTSSEATRTLTTLSASANTALAWVPNPGVWQFDPPEPAFELELNLQPMSLDSAMLGTALDRMGSVSQMTGLGSQELAYALSGPSGGYSATSDVAHPEVVSLGASSSPSFAAQFSSSPTEAASSVSPAESLSHSFPATRSSSRSATPAAHPEVLSSGTSSSPSFAAQSSSSPTEAALSVSPAESLSHSFPATRSSSRSATPAVTSATIPPLLVSSARRSSLPSHQELNSAVDSADIAPPSITVASANVDTGPACKHHQGRRRAVPAIPAATETVNASREDGALAAKSGRPARIRVAPKQANAHWSRSGKQQPIVTAGPENQPSKPPISHRGKRVAEGQYGGPPLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6A0</accession>
    <name>A0A401H6A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_1702920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000017">
        <property type="protein sequence ID" value="GBE89966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620879.1">
        <property type="nucleotide sequence ID" value="XM_027765078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6A0"/>
    <dbReference type="GeneID" id="38786883"/>
    <dbReference type="InParanoid" id="A0A401H6A0"/>
    <dbReference type="OrthoDB" id="2678860at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE89966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="76" mass="9190" checksum="FEA7F5DE47951262" modified="2019-05-08" version="1">MAPPTWANNEELDWLTERLPHFLDHQKRKKVQSFFRTLYTEWDARYPERTRLFPDIELTAQLTPEQEAELMEAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401H6B6</accession>
    <name>A0A401H6B6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_1800090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000018">
        <property type="protein sequence ID" value="GBE89987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027620900.1">
        <property type="nucleotide sequence ID" value="XM_027765099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401H6B6"/>
    <dbReference type="GeneID" id="38786904"/>
    <dbReference type="InParanoid" id="A0A401H6B6"/>
    <dbReference type="OrthoDB" id="2777543at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF72">
        <property type="entry name" value="IM:7136021-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE89987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="537" mass="60134" checksum="DAB05CF22B5191EB" modified="2019-05-08" version="1">MDLTPARAALRNAEGFLARLQTDPRITSLDALQCVERTLNAAIISVRDQYNSSRPVNCLPPEILRYIFRQVLDPVKMGDGMFMWPSALRSTKGLQELSFVCHLWRQITLDDCFLWSHIHIGQLYGPTTDMFLQRSARVPLKVCSLAQGRRPFVETLSRVERTRIEELCISSPSNPHFYTSFAAPALRRLTLQSTVDADVPYLVELFRGAIPQLCAMSLHAAVWLPSNCFPRLTRLYLSSKLKPVAPHAHWTLSALSAFLSNCPVLEALIFGNINPTLAAGDEALPVVNLHRLRSLSINSSATAVIQWLLVHLLIPVDASIGFRPRREANDTVLDILLSLPRLKDMRTMHLRATVFDPDKIHIITSVSNSSSSTCLESTIQDYTKNVQDEESTSRVQTNPAAIGQFSGITHLHVADGGWVQKFVNFPALFMILPYLSFLEYEKGDNDLLPLLLKGLLPPDDHSVAAPIPCKSLTILKVSMGDISAMFESIVEFANNRHRIGYPLAKCIVLNPAIELDDMRILKQYVETVEVRFSCPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G4S5</accession>
    <name>A0A401G4S5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0100310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608072.1">
        <property type="nucleotide sequence ID" value="XM_027752271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G4S5"/>
    <dbReference type="STRING" id="139825.A0A401G4S5"/>
    <dbReference type="GeneID" id="38774076"/>
    <dbReference type="InParanoid" id="A0A401G4S5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1134" mass="122196" checksum="6B7EAE106988E63B" modified="2019-05-08" version="1">MLSSAKLAMTLDIDPNYVLQAARLTAIVAAAPRQDDPRYSDWEARIYLEVSRLEKSFLQPLKSLRMPGIVISALLEFTRAYQQKALARLDHISNDDERIYKRYPLAVREYGECEDLGRQWWTEDPYCKLPPVKSTPAEGWGNVPADDDTQGRGEEDLATGDLITKGKGKKRADNDIGTGMVGERIIHVEAGEDKGKGKSKEKAQGKAAHAMSEEEDGGEGEGEEQEGEDDDDADSDEDDDADKDDDDEMAEDVLGAGQPESIEVDAASPPPPTARPISISPAAPSLRKRKVVITESSEESENEEVAPKTKRMKPIEKRMVQTEVEGSKVSTKKSGKRKAKESSDEEEVPTVKPPKKKRATKEYKSKEFIESEDETPAPPSNLPAKTTGDSNDGVAKTNAPAKPVKQTTRMTATPHVAPKAKAKGNAKAMAKGKAMVKAKAKVTVSQKDMWKKTSTRVSDFMWAHATDSLVPCVGCQKKEWPCKLNTANFGRCLECAARGVSCSIAPRNMDGVPLRGNSHTAQREFQEMCAALVVEGKPLPTSPPPYDVKVDSDEPDGAEPMVMGASKRKPLKKTKTRNAAASSSMVKGGEEVEATKQKATVTPYEANAEGEASVEKLSKSKRAPKFATATGAVALSNSGEVSKSGTPAKSGAVAKPGEGKKSGPKAKPVRSQNSGAQDGGEVTRTSVREPDEVPPAKSVAKEGGQTTRVAMGGRSGPMVPVITRKVKVSAPKAAAKMPLVEGDGMEEAARLAMEAVRAMAFQTGPAAPPQASSSKRMLTPVADEPEDAPEYQAEVAEDERASLERPHDDRRRSLLMPHEMSAGAAEVAQEVTPSLEISKASKGAKSSTLAKAGHLDEGRRPAKRGAPLDRKAAKKEVEAKRDVKANRLRAVPPTSKAPHLRDVQRVSTGSPAPVNEGDTPSGEETSQSSNDDCANCAKLRQEFLAHKDGMEVQFQERMADLNTVKAEITAALQRINPPSAFQENARSIHEEVKLAMEEFRRPVTIELQESVKLEQGANQTVSQADVDKLQGELADLRHSMELQAARSDSMEKELRSSAAEAIAQASKLEMELALAKEDSMAVATSALDEAKKVGKEVATAREETSLVAKSLDAFREKVDSAMVFTAFRPDSHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5A3</accession>
    <name>A0A401G5A3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0102150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608255.1">
        <property type="nucleotide sequence ID" value="XM_027752454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5A3"/>
    <dbReference type="STRING" id="139825.A0A401G5A3"/>
    <dbReference type="GeneID" id="38774259"/>
    <dbReference type="InParanoid" id="A0A401G5A3"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="83"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE77342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="555" mass="63857" checksum="E2A74886E3984D6E" modified="2019-05-08" version="1">MDRGYLHPFQDGRQYLYGVGERPRTLLELAMCQLSAHIRSTKNWWKEYGDHQFRTRWAEEAAERSWTVRSPSGSTLVTLSRRQINYVLDELDGYAALRDEMHGCEVSSIDRIWHSDSLLDSETLSSLDTGLQCLPGRPNDDSVSVDLVDPFFHCLVYNRTQVYDSFAPESFSLQTRPINTPPSFDYACSSRFACIPTAFSVSRSDGSLEAKVLSYINNIDPSNTSLYHHIEHVVSRCVTLFEYVLTDLHRNNPLCQRITGSYRYTEWNEPEEPEFSDDDDGWLAYEREVRQWTLHRPIQPPDVPEQGYPRDLHTRHFKVTLDGRVLRLIVRVTDIRVAPGGPVYTGTPWHVEGMRNENIVACTMLCTSMTNLVPPSLEFRMAITAPRMEAGDVGAAIRTWGLDHFSARNQYLGHIPLSPGSAVAFPNLYQHRLTATHLRDPNHEGSMTFLGLYLMDPELDAYDGKRDSGWETLSPSSDTVPPQQKEWMRRAVEDSIDVRLPFEIVERIVEEVEGVMTAEEAAAYAKEMREERERFWTLHDEYRFCLPFDIWEVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5A6</accession>
    <name>A0A401G5A6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">SCP_0102120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608252.1">
        <property type="nucleotide sequence ID" value="XM_027752451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5A6"/>
    <dbReference type="STRING" id="139825.A0A401G5A6"/>
    <dbReference type="GeneID" id="38774256"/>
    <dbReference type="InParanoid" id="A0A401G5A6"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019570042" evidence="3">
        <location>
            <begin position="20"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="GBE77339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="625" mass="63566" checksum="2CD3F6F94EE1C9C7" modified="2019-05-08" version="1">MRTKVILPSILLCASGASAVAFKREIEFVTPARRDAESVSGVQQHGQQQPPEQSASSISPAAQTTDTSGGDSILSSINSDILRWLTQHQLQGGDDSGVASSYLQHPAGEPGTPNADPEKRAYIMRKPIIRKPVPQRPRDLEERDVEERDLQERAYRKPIGIASIAPRPTRYHRDFEGRDVEEHDHEERAFYWRKPALVATDTPGYPYVVPSPRPRYVIHQERQAAPDPAMYTQMQGVGLQIASFFSSLLDNMPTNAAAPPAGATPAVANSASSFTTPPAVSFTATSDGPSSSAVPGTVPSTSAGVTSMPLVAPSTPSVIPSSASDVQSLASDAQSSISASQFSSTALPSSSSTDASLSTSPTDASASVSSASASAPSVSSSDSFAPSALSSISQLSLDLLTATSAPFPPTAVSSSSSVPSQSATPFSSAPPAPTAAPSPSSIGAWSIVPSSAAPEDLSDESSSTASPSVSLVSSPVPTDESSSSDVPSASSTADPSSPSSSADPSNPSIASAVPSSDSSAPTAAPTTIASTPATSSVLIPTNLYPIYSRMSFALSSTAIPTSSSAPDSNSNADSASASVSPSDLSALASQSANAGFRSYGTLLSSTLTGVAAIVGGIVFGSLSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5D2</accession>
    <name>A0A401G5D2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Splicing arginine serine-rich 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0102440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608284.1">
        <property type="nucleotide sequence ID" value="XM_027752483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5D2"/>
    <dbReference type="STRING" id="139825.A0A401G5D2"/>
    <dbReference type="GeneID" id="38774288"/>
    <dbReference type="InParanoid" id="A0A401G5D2"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="34018" checksum="328E57580321B77E" modified="2019-05-08" version="1">MPSESYPRDRSHSRSRDRSRSGSPERRIQLPSGASPISESDYFLKSDEFRIWLKDEKRKYFDELTSDKARRYFRKFVKAWNSGKLPKSLYAGVDPSQAASSHTAYRWSFTSKASRAEADALRAAREEVGSATYNRPSHTDARASRGARLQGPTLPSASDMTLARETADEARAAERDYQRKRDKREQKERVEEVVGPKPLGREGMLEKKRTQRESDREFRERGDEGLELDESTLLGGGDSFKDRIAKRDAARKRFEEKKFGGRDERLSAARERADTIRQKDKATMDMFMQLAKNKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5N2</accession>
    <name>A0A401G5N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0103390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608377.1">
        <property type="nucleotide sequence ID" value="XM_027752576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5N2"/>
    <dbReference type="STRING" id="139825.A0A401G5N2"/>
    <dbReference type="GeneID" id="38774381"/>
    <dbReference type="InParanoid" id="A0A401G5N2"/>
    <dbReference type="OrthoDB" id="2422840at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1196" mass="132540" checksum="AC85B58DADD50A47" modified="2019-05-08" version="1">MGDNEHALRAHIRNLLLDYCRTHLTIDHVKFTRQAASELLAESLNYIPTHDPASLLLPTDPFDFLAKKWRLDSIEEYEEHPVVSAEALQYVKQKLPRPGKPKSSTIWDEAQDVDYERWLSRRPMSPVLTAYALRETPKLGSRSAADMGPKSHTGFLDSYGIHPVKVEDDEEQPRLDLDDALDNKPSMNAETYAAVTESIRFAARQLNSRDSAPGDNAYARDFLRADSPIPMPAQLDSPPLFARDRLPGHRPNALVSYPHPAGLKSMSDLPALVPKVEIKKEDEEEDLYKEHLIVVNGWQAYNVPSSPSRTPSLGGSSSEIDELFPPSPENTQLFIESLASAQMDEYELPRSEKVGRARVRPKVIGEGESLGSFLGSLLQPHQVRKERAQIVTTPKSYPSSPHTTITMSMLGQPPSVLEDEFNIGDAAPDNFRGYMSDPDLEDIVGRLCGGVPDEDLTDVIIREKIDEKYCLLMDVPELPPPNVHPPSIFLPKKLSDLVAVPEPLIPSTSHDKQPFEGLRKAKGLRSLTMELTWMPFKYGRTIPTDEDCAGVTDANSIRDAILKWIGDDETRAVTELQRLLEEALSLDTDLDAETSCPPSMHGWWDGGSAADDLRSGDYITNNIILTRMDRRKANGLSGDAFGNLSQDEDASVDEVDQRKKRVKFDDHHRTADGPAHYGDDLHQVDDSGILMVEPDCVNGSDNVFSQLALGAEGFEGALADGDLFRDIDPIHHIDHASASPRALRYSPMVSARYNAHSTYEVTTAAVGLPEQHYHHEGELWPVNDAENSAAFMPLSFDSAHVPIAPHTPEPDAPSPRRYGFAPDVDPSQRNVLISADGRESPNVSSTTLIQAPARGISGFSPMTSARQSLADFLKFRGKSFATTTNADPHSALNAQLSVPAVHDSATSRDIPEELLDSRTLRLHDHRTLPTTVHRYMASMDFIQKRALVVALSSSECLVDLTERERLGDVELIVDPDTAILFSTLAALPSELDSLMMRLTQLSWRYMHLLVILEAYPPSSSYRHDHDSSTAAPYAFSPPVVKAVKKLRRDLSIADACRSKCSMSTVHFAFANTVEEAAMFTRVYGDIAQDRDATGGAIWGAREWLDLDEQDGELDLAGVDGMNMFAASIVLCQISLEDFLDQTPEERLDYYAALVGTERITRFNEEFTRRSAAMELHSSPLSSVHDQSDRLPLAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G5Y7</accession>
    <name>A0A401G5Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0104520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608486.1">
        <property type="nucleotide sequence ID" value="XM_027752685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G5Y7"/>
    <dbReference type="STRING" id="139825.A0A401G5Y7"/>
    <dbReference type="GeneID" id="38774490"/>
    <dbReference type="InParanoid" id="A0A401G5Y7"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE77573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="736" mass="79689" checksum="371F3D226B449B48" modified="2019-05-08" version="1">MSHSELPSPKRLRLSSPTYDEQCCLSQEEIKAFDDYEKRMTQSSSSIPQPSHVSLPGSGKRKREKSIQQDPEDNGDSDVSHDKSEYESSANSLLQRATHPRRDVRTHPSNTEPNAISLFASSAELSAKEDTTAPISFTDLPAAGRSSGGFTSAALLTPQEHPATSQKDTNNDDIAHRTTTVTPAKRSGFGFASALTMASNPQFDSIPSSSPDATPEPDYSTWFEPSTVPETAMVGFQSAKDISKSMAPLECAAAGSAGCLSGFKSGRDIFLKSFQPEHEEESSSTVPLKASLPGFTSVRLLPGVSGTPADPSLSECTSGLSVFNPNSSNGTKGKARASNWTAPSAEALARAQQLMKRWEQEMDSKSTDVAQPEQGKENIQGAHPSAAFETPSRPALRSVENAFSPAQPPESPSPAGAEMGKPLAPASRMGIQSKNKMFKSPLLMRPPQKAASSMPFVAPLLNPQDRPSAKLPAAFPALLPAEASTSDLPSTPAPRAKALGLTPRRLGGMAATGKPKFSTPFKLGMRPGEPGRSQLEQSHAREKEVTITVAPMQHGSPYSIRPKKKQHKFFDLGKQVSRVSLTATELFPQKWAADELASHGMFVPTFIVYAPIKLNIFRSDAKELDTITPGLALYYSFHATWDAPTSTPSEPVRLGADAALARLLELGCKLVTKEWTDNHWGLILWKLAGMVCMNPEHEDNPDERRWCFEEVVKQLLYRQGNISTHRTHVPLILIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G620</accession>
    <name>A0A401G620_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">SCP_0104910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608524.1">
        <property type="nucleotide sequence ID" value="XM_027752723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G620"/>
    <dbReference type="STRING" id="139825.A0A401G620"/>
    <dbReference type="GeneID" id="38774528"/>
    <dbReference type="InParanoid" id="A0A401G620"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="GBE77611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="788" mass="87684" checksum="2FC30DC576567C38" modified="2019-05-08" version="1">MPPVTEKEHVNGTTNGELKQRRRPGRVPVSCAECRRLKLRCDRKVPCETCVKRGCAAICPEGSLTTGRANRGAIAGVEELHRDIERLRTRCATLEDALRTLQAKITDEPHPLLSDSPNSSGTPEWSGGPTPDGPLLSRADEEVLDSFGTLTLGLRGEARFFGQTSRSEYLIHAPCCGYMSYTSFPHLSKELIDEAIMELDVPCENPTIHEEIRRALPSLSQAYRLCEIFLEYGQYVWYPIPREQVFDEIMGEIYRATPPSDTCFSCSHATSLLFAIFALATLFDLDAPPYAIEAHEYYLLARLCLRFAPPIRDTTLTAVQSLVYMAQYLELSDCEPAHTGSQKAWLLVGLAVKLGYSVGLHVNSSRWKLDDDASQRRSRVFWELFMQDTWISFGFGRPPSMSMSFIDCEFPKDTQAFISESGARECSYHNWTWQFSKLLHTIVSTAFGAKSPSYATVLDFDRKVRDFPVPPHLRPDCTLPEFERMLPSFFMRGFFVVSSKESTLLSLHRPFFVQALNEQPADLLRHRYGPSVMAIYRSAWRSINGAKEVFKRMPAVISRFGLTWSQCIAGGIVMCLLVTRAPSSPLASSALQELVNLCELFERAAETCQIASNNLDVVRKLYRQGHETMSKSQSQKAPGMTANELDRLGGKTHLISSNSDIAQQCPYAQPRRMDPFIVPVPAPVPAEFIHPTIMQDLRSFDGLNPSGYVGMEPSPFYFDLLPGPSGAGAGAGVGAGGFASSSVEITPEVFDQFFAQNGFAAPVVEPEQFAGPPVLDSTWQSFVEQLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G6B4</accession>
    <name>A0A401G6B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0105850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608616.1">
        <property type="nucleotide sequence ID" value="XM_027752815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G6B4"/>
    <dbReference type="GeneID" id="38774620"/>
    <dbReference type="InParanoid" id="A0A401G6B4"/>
    <dbReference type="OrthoDB" id="2780168at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE77703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="633" mass="74147" checksum="7E805B80F94BDF29" modified="2019-05-08" version="1">MREFASFTSPSSRHIMSLHRASLQGLPEEILSEIISYHGYQQNIPRRYRIAYTLSQVNHRLRESALPFLIRDIGVRNCQVACSVVRCFRDAPDQARLVHSLKIGNTLYGRVDNKIVCTTRFPDFKFFCDVAAWPFLNLRSFECVEGSCTPEDLDVLHGCPHLATLALAWRDIFAFPNLDGWPELEVLRIYPYSSYIHRRTVRPATHMTFNRLTTLVVQDAALSPWWNNHFDLLTFPNLHVLSLQDLISSPNEVYGFIERHPSLRECNISFHGLGMCLSFEGLMMLIEGTGIWTHHNLPMLSDDHEYEEEKSQQTLFDSPYFQEPPPDERGETYIRFSSFAFARVPFVPDFRLTPRDARYKVTALALPVMDQETWIQRDIPVTDIPGFMRTVDRFPEMQELRLASATAQWYETFTYFMNEIAAPIGEWTHLRKLSLCYEMPHCWSWGPENDEVSLPACDIFVLDDVEPPMYSLDKEERPYFWDEEEADPLKYWKPHRYAPMNLRYLREEFPMEMPAFEEALRWTLRVDDDVDIDPLDRNVLIYAWEIRHAPRCARKVRYLAERSRTLEEFEWFLNGPHGGVRWMWKIQRGKDGRIWSVTGDLNYVGSVRGNPPPFLVLVGQELQTSLAPRSLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G735</accession>
    <name>A0A401G735_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">SCP_0108400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE77958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027608871.1">
        <property type="nucleotide sequence ID" value="XM_027753070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G735"/>
    <dbReference type="STRING" id="139825.A0A401G735"/>
    <dbReference type="GeneID" id="38774875"/>
    <dbReference type="InParanoid" id="A0A401G735"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="GBE77958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="301" mass="32751" checksum="5107B0F24ED1116A" modified="2019-05-08" version="1">MFTGNGIKLFSGTSHPELAEIIARRLGITLSRAEISQSGIGETSVRIVESVREDDVYIINTGCGRINTALMELCIMVHACKIASAKRITAIIPLYPYARQDKKDKSRAPITAKLVANMIQKSGCDHVILYAEPSAIQYIRSNFDLSEIVIVSPDAGGAKRATSIADRLGVDFALFHKERKKANEVSRMILVGNVKDKVAVLVDDMADTCGTLCLASHHLSEAGASKVYGLVTHGILSGNALKSVEESALEKLIVTNTLPQQENVEKCKKIEVIDIGNVLAEVIRRSHYGESVSKLFDEVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G809</accession>
    <name>A0A401G809_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0112050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609233.1">
        <property type="nucleotide sequence ID" value="XM_027753432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G809"/>
    <dbReference type="GeneID" id="38775237"/>
    <dbReference type="InParanoid" id="A0A401G809"/>
    <dbReference type="OrthoDB" id="3270899at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="83" mass="9511" checksum="96F9188EF2CF5E37" modified="2019-05-08" version="1">MYREGRLRSATDFHCRNQGTVEIQEKGKAEFRKFVLNTYNAMIVKETIMDQGNIPSLALFCRFDIGLIEYHNLHCFIGGGAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G841</accession>
    <name>A0A401G841_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0111980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609226.1">
        <property type="nucleotide sequence ID" value="XM_027753425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G841"/>
    <dbReference type="GeneID" id="38775230"/>
    <dbReference type="InParanoid" id="A0A401G841"/>
    <dbReference type="OrthoDB" id="3317898at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE78313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="140" mass="15702" checksum="73B33C635C7703D8" modified="2019-05-08" version="1">MPPRISSKPSRQHAQRDEAFVRDMTERYTNYLVIAETCGRTVRGMGYGQNDVARVQPVYDQAARDWRNDPTIILRTNSTDPNEQAAFFRQCDSICATPLDTLYKCFWVGFAATAGAQGLYCLFGNHPARGKIVSDATDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G8L1</accession>
    <name>A0A401G8L1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial dicarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0113860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609410.1">
        <property type="nucleotide sequence ID" value="XM_027753609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G8L1"/>
    <dbReference type="STRING" id="139825.A0A401G8L1"/>
    <dbReference type="GeneID" id="38775414"/>
    <dbReference type="InParanoid" id="A0A401G8L1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="7"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="97"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="203"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE78497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="294" mass="32078" checksum="3AE84E5F66D2ACB5" modified="2019-05-08" version="1">MSQQQKYPFWLGGVGASMAASCTHPLDLTKVRMQTLPPVAVKRPSTFSVIRTTVAEGGFRSLYTGLTASLMRQMSYSLIRLGSYESLKARLSQHGHASTGQLLLAAMLAGGMGGVAGNPADILLVRMTSDSIRPPERRYNYSNALSGLVALIKKEGARGLFRGLGTNTTRAVLMNGSQVGSYDFFKSTLLRHPIPIIEYHFRDSLLLHTVSSLLAGTVATTVCAPADVLRSRVMSASGKSSPVEVLKTSLQHEGPRFLFKGWTPAFIRLGPNTVLMFVFFEQLKHAWRTLYPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G927</accession>
    <name>A0A401G927_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0115710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000001">
        <property type="protein sequence ID" value="GBE78680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609593.1">
        <property type="nucleotide sequence ID" value="XM_027753792.1"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401G927"/>
    <dbReference type="GeneID" id="38775597"/>
    <dbReference type="InParanoid" id="A0A401G927"/>
    <dbReference type="OrthoDB" id="3357224at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.360">
        <property type="entry name" value="SFTPD helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1839"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1895"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1493"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1619"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1685"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="912"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1850"/>
            <end position="1862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE78680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1920" mass="211150" checksum="611B2511957DE9F0" modified="2019-05-08" version="1">MTAQPHQPLSRLFIPPPISHGFADTAPTYSPGLPTAIHQGIHPPYGMNVPNPMQAMQTMQGMPPLQTPMQPAFFPQPPGAPGRPTLHRSHPSVAQLAAAGILPPGIPVTPLGQNGFHFGPMQPFGGQPFMPRNKRSLSVSVGGPPKAVLGGPQRKVSPLPAPAAVIPPPAPVVRPKKVIVNFPRESVPEEARPSWARTPLFPVPEQPDVQPPELASAEQYPPDEWRLTLPNTVDVFLPGKSAWDDMRRTLIEERLEKLGVERGSGSIPNIHAPHARAASISSPADPALLYFKLNKLQQSQNASGSNSLSSSPHLNSSPSPSQLPPRLQNRHGHSMSLAQPPSFQSHSPVYNPAGAFNPFGPTATLGSDQMLINRLSPAPIPSLDNIHAPQGRVPANFSTLAPPQASSRPESRPDFFRGFGLDVTEEEEEPMEDVPAREGLRGADSPSVAEAEEEEEEEEEEEEVYDATEAAKEEYEDLDQDGVSTVAQSRIHSRHVSRLSAALSLRSVGGMAGGFTQAAGVALDVVPSLSPSAVEAEDLDQDPDQDAVGEWTGSEDLRTGAETSEDESIGEWSNPSDEERARQHRVERRMLRRMKQEDPEVPRRIPKFPIPPVTQAVKDDDIVSNPSEEDHAEVQEAYLGLGKEGYHSRPGSNLSGKIRPLPPLPNSRPGSAPYSYHDPALAHSRETSVSYFQPGGIQSRPPQSQTAPLPRRDSLNPFAKPFVFGANSSGQTTSSNQAPVSAPVLPSTFDHERTASFGKPLNAAAQEFKPSFTFRPPPGVPQLAFGAEASRPLPVPPDVVPRAQQGREKRQRRVSSGSYVSEDEDGVNTMSSFKFPPSADNTKVMRHSAPSSPPQGLISREMSLNAGAKPFNFSGFSTLPSISQQANVLSQSPVSDEHDDEDEGDDENKPLEQSPTEPAEPESALELPFPPTSKPKRAPIPLDFKHPVSTNTVPAGLFRSLANGDGEERTRRGVRSRLSSRDIFEHSPHQSLDDLNVPTISRRVSKSRLFTDPGLRDSPLSIVDVFSADRRRSSLPPRHREDSSLSDISIPPVNLTRRLEMHQYEQRLEELLDEKLEFIKRTLMDVKQASSGSSLNPSTENMISEVVSLFRTQLQESATRGLADSEMDARGELDFEVLKGIIEQSHAETRALMQRDLFEILRTHAQEPTMIQRVEELSHRTVNAVVSATSQLAVRMQTMDISRSSPQVEMESIVHELMNLLVPQLAALRPEPIDYEGLTAQLTQAVKPHISQLIDLASDKRETAGLIVDSLIPILSSLHAQTPPFDTETIVGRLTTEVRKIVAPLDAHEIKEQVSDLVVERLDSRLAMRDKAFNVDVLSEKVVDSICDLLAPVQEIQSAVNALVDKQGTSSEPALASVKEDILGVLSDLPQRLVAATEALNVAQAEVKKQTEDSDQVKPIAKNIQDIQAALGNVTREQQKLASQNQEFSDFCQDIIKHINTLPEAMVEATSILQNAHADFAARDTSQKDAEEIRRLMVTAAELQVQLAKARAAHGQVRVEKDIIMDRFKTSEAEREHLISKVEELQNSLTNKNAEVVTTELKNAELEEALANALDRLKAADVQAQIQHDRIAQVEKGNHELALENQQFKSQAEALDLRVVVVSREKESLVEELANQRRQYEDLALQQSHWDDLRHATEQIHMLSTLMGQADNEELKELKYIRDRSKVLEGEHSALQRRLKEYENKMVSSEKMAQASRQSLAQAQQRAVEWERLTKEYESDLEATRSKLDEVQQAHSQLDGDYSMAKMQLEERDAEERLDKDRQSKLRDQIAALEGQVARLQAEVDQAKKAVTSAPPARYQQNGHAHPVARPESRASTVYSRAGTPPASFTAPGGPTARATTPRQSSIWDSMHAPKNQVPIRLPVTPKAQRLSPFYRSEIPSPTPSNVSAAPTLGNDGWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401G9X6</accession>
    <name>A0A401G9X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dehydrogenase citC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">SCP_0201650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE78968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609881.1">
        <property type="nucleotide sequence ID" value="XM_027754080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401G9X6"/>
    <dbReference type="STRING" id="139825.A0A401G9X6"/>
    <dbReference type="GeneID" id="38775885"/>
    <dbReference type="InParanoid" id="A0A401G9X6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="593"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="GBE78968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="613" mass="66684" checksum="FC7727CC98E00DE2" modified="2019-05-08" version="1">MTATVAQVSGGKFDYIIIGGGTAGLALANRLSEDPSLSVLVLEAGAANLDDSTILVPGPGNRRKLLNNPKYDWQFKTIAQPHSNNRSYAWSRGKGLGGSSAINVLLWNKPSRDYLQAFEDLGNPGWNWEVFEKYSKRAERFVKPDHDLDILTYDMAYRGDSGKLTPALPSRTLSDFRLRPMAEALEKHGITHVTDSSSGFTNGSTSTALTLHPDTHQRSYAANMYYVPVASRQNLAVLVNAHVTKINSRSSADGTITAVGVEFLHAGVPQQVVCMKEVCLCAGAVMSPQILELSGIGDPDVLQKAGIDLKVVLPGVGGNVQEHLFAPLFYELRKYSHDGWNFNTYDPLYDPQEAMKQLALLPEGKGLFNLCTTGLTFVPLNTICADTTTIQKTVSETILAGIAQNVYPPGLRKQYTIQLKHLEQQVPSLELILGPGIMIPPANPDPTRKHITLGFGLNSPFSRGTIHVGSSDPLVPPVIDPHVFEESYGEYLTTMVELVKFLRRLAKTEPLKSLLVETEVSPGPQVESDEQIAEWIKNNVSTTFHTVGSCSMLPEEDGGVVDPQLRVLPSVYHTTNIRVVDLSIAPLQIGAHPQAMVYAIAEQAADIIKGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA72</accession>
    <name>A0A401GA72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein phosphatase 1 regulatory subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">SCP_0202830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609999.1">
        <property type="nucleotide sequence ID" value="XM_027754198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA72"/>
    <dbReference type="STRING" id="139825.A0A401GA72"/>
    <dbReference type="GeneID" id="38776003"/>
    <dbReference type="InParanoid" id="A0A401GA72"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="336"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="831"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="831"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="788"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="GBE79086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="859" mass="93585" checksum="EFB9F423D5CDC989" modified="2019-05-08" version="1">MEYSGAWLQQHQIPDLQAVAHDGQHPANDDWKENTSVQPSAGSSQPMDLSDFVLGDMSVPPASSSSLSSSSTGYFATFPQQGFFLSTTPGPFNVVQYGSSPWAPNSNQLPLSSYSSLNGATSASSSAQQQSSSSNPTMMIDPALTTMSMTAINSSASPSIQHYQHSPPFLSSQPQQRTQFQYQHQPHQPTLSINPSFVHTSTSHYQAPQLPRSTSQQQQQQQGTLSPFVLHSPANTLNSPVTPNSFYASLQPILNHSAPTISPEQRKIEFLNGIRPLLSPTSFTGAGAVSQLVGYIEDYGVQEVEPQTRLEILTKMRDNAGNHYFRAWVENEVAMDVTREWLKLAYTGKNDPQLVETIMPLLHVIDRLPLTIESLKSSKLGKIVVRLVKEPPAPAIKDMAANLERKWRQLLASSSDSSKHLDSEPTEDVKGKKRKADALKAAPPAKKVVLTAPGSSSKPVVVKKESSKSVVREVKDAKTDSSFFSAPKPKAKLPSFKKAAPAVVKKEPDPNVSQPSSINPFEEALKLMKSRKDSPATATPPPMPAPSVPVVSTGLTSSGKQKKRVTWAPEGKLEMVKLIERAVYDDDPADGMHTTHNVRDLDRDEGAALHAHLFEEQIEWLEPILIVIPPDIDARPKGEQSQEKVTQEQREQSALVALYMSAAQIPDSPAEPPSQIPEEQVDEKVRMMLTGPEVDTIFWSGGAPAALEPPKSSVAELVGQLASSSGDVTMGDASHAGQQLDPKSFGFDPATIPALANVTPEQLQNLMQQAQALVAQGGMFAPGQSGDYSERGGYYDEGRDRRWSEEGYSDRGSSRGRTRGRGRGRGDGYRSNKRKPCSFFAAGRCRYGDQCDFSHEPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GA75</accession>
    <name>A0A401GA75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0202650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027609981.1">
        <property type="nucleotide sequence ID" value="XM_027754180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GA75"/>
    <dbReference type="STRING" id="139825.A0A401GA75"/>
    <dbReference type="GeneID" id="38775985"/>
    <dbReference type="InParanoid" id="A0A401GA75"/>
    <dbReference type="OrthoDB" id="2757368at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="787"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="895" mass="97765" checksum="F9D45319A0CFA3C1" modified="2019-05-08" version="1">MQRPVWNEVPAVQVSPTRVPFSHSQSLLPHSSTSENSNLRLDVSVSNGSRSDHSLPTPPPSASLPYAQYPSNAFAGPARLPRQDATGNIEGAPAQAYINQGGHPEAATRHVQHHYTQAGPSNYAQPRAQTIPQGYTPGSVGTVHQSPHPNSWPDADASPASPRAIPNDSLIRRRSGPSAPSSSSTQTQDGQNNSANNQPNPAEPPMNAATSHAHALLHPLRGYLMQKVDQAITATGMRLAQEFGTINEHTAQRERQLIALSSRQQDNGASAAEANALRQERHSLREECMRLTEDLKNAQEAQVRMKDNLMKLYNACFALREEGSKLREERVALREENWALRKEIARLVDAGNENVQSSGSLGKVEGEAAQERSGLVASVLSKVQQELTRRHNAAKEVAFLEQVVKEIAPSEPTVNSASQDVKESSEDPVARLLAQSSPVVLSRLASLSCSRSEARINHGTPPVQASPVRKFEPLQTVDNVPSSAKSEPDPEPRLLPAQTANISRRSAVPPSSIREVIDLSNILDSPPRRFIGIEDALPSPTNDLKMSAPHLTRAADSEVNAAMDVDVDRKREREGSPEQPEHPAKRRRTSDEVTDSASGTVETPQLTEEKLVAATEPLHRSRSSEDWLAYALKEESERVTTPDEMKSLQERLVSVQPSEDMSISESGSVATISTPGLETSAPVVESVKLVKTSALAAAETVAETTKSEVMESVSLNEPRMSRVGLGDNTKDQHEASERNLSASASAGTKSWVVDDQNAPRAQYHRTKLLSATKRPEETPLIEAYKQAEVQSRAPQTPQVQLEGPRPPTRPQHRKHLSLRHVPLMYRSTKTGMICRMCLSRKEVRDRKLPVTTFPLAASWVELASHCETVHPRAYETLIGMAPEEIEEAKLKLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAN7</accession>
    <name>A0A401GAN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0204310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610147.1">
        <property type="nucleotide sequence ID" value="XM_027754346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAN7"/>
    <dbReference type="STRING" id="139825.A0A401GAN7"/>
    <dbReference type="GeneID" id="38776151"/>
    <dbReference type="InParanoid" id="A0A401GAN7"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="555" mass="61540" checksum="30F8C800C540CE62" modified="2019-05-08" version="1">MSRDDKLKVVASSALSNLFSTHKVHTPISAFDLLTRIIASGPPPAGLLPGPEIPPSFRLTDLSRFEAILEGFAEEWNFGLVEVSREERDGGLTVMDVQLGEAGQQQARAVAQSRKRKRVVDEDADSAAGDSEEDEEQPRNIKPAPSTLASLSRDMREIYNILQQSTAKGRLLAEQFHTVNGSFEPICSHITKDECAKSRRLSSQSSANGLATICDRIHFRPLLRPHTDPTLGHCSYLNTCYSEPTYAQSPSIPPLPSHRAVGYGAQGGGAVSLPSGLGAGGRGKEKAPCRYLHFEVDWDTSDGAAYVEKRTEVKRTPFKLGIGLGPTGKEGKLPPQWLNCDLRRFDYSVLGKFHVIMADPPWDIHMSLPYGTMTDDEMRAMPIPALQDEGLLFLWVTGRAMEVGRECLRVWGYTRVDEVVWVKTNQLQRVIRTGRTGHWLNHTKEHMLVGVKTVTDADGKLKFPSWANRGLDTDVIVSEVRETSRKPDEVYGMIERMCPGGRKIEIFGRKHNTRPGWLTLGNQLGTDQIYEEDLAARIKARYPERVINASQAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GAT5</accession>
    <name>A0A401GAT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0204500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610166.1">
        <property type="nucleotide sequence ID" value="XM_027754365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GAT5"/>
    <dbReference type="GeneID" id="38776170"/>
    <dbReference type="InParanoid" id="A0A401GAT5"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="191" mass="21220" checksum="B3698A8D12D593EE" modified="2019-05-08" version="1">MSTIVSPLSLLRRASDSPITTPQTCAPYQLVPPITVAPHFPVDPDQAPPYSLPFNTAAVVRDRPRSFALTSRSIRSSDFPIPARTPRTFERKYLALLRTHHPALLAHVELVVLYFFPFVHASPRRAHGLRSPLTRRAPSHSPSFIPHSPSLHRCQLSPQLVIRIISGSQERSLDNSPSTTPRSPPCSSPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GB05</accession>
    <name>A0A401GB05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">SCP_0205520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610267.1">
        <property type="nucleotide sequence ID" value="XM_027754466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GB05"/>
    <dbReference type="STRING" id="139825.A0A401GB05"/>
    <dbReference type="GeneID" id="38776271"/>
    <dbReference type="InParanoid" id="A0A401GB05"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="GBE79354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="481" mass="53135" checksum="46204C30BB2FC065" modified="2019-05-08" version="1">MSTPPTKPRVLIVGAGIFGLSTGYYLSEDGYNDITLFDQHPYDSEQGYTMNPLSTAASVDEHKIFRASYGNELVYQRLAYEAREAWKKWNEELGPGNEIFIESGMLRLQHGTHLSGLERRTQKNMVAEGLRETQYILSNENDVRRAKEDGWAEKLVKFPIPGTNGKEHFEAVLDTTAGFVFCSRGCAYLADKLRKKGAKFVHGLEKGAVTSFKIEGSGDSKRIAGIVTKDGKEHAGDLVIVAGGSATPILVPESRSVLEATAGSVAFVGLPPRKEAPELWEKYSPQHRPVIIGHDPDTTGKEVGSRSIYIFPRNSEGLVKIGYRVTKYTNYVNLPGSERPIAVPLRPGVDDTALPLQSVEAIKTFVSTFMPDLASFPIVKTRLCFYTDTADNAFLIDYVPGYSDTLFLCTGGSGHGAKFTPVLGKHVRDVIQKKPKTELTKTWRWRPELPLGNGLEEGPTGPRTFEKYERSTPADLVRSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBP4</accession>
    <name>A0A401GBP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0207940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610507.1">
        <property type="nucleotide sequence ID" value="XM_027754706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBP4"/>
    <dbReference type="FunCoup" id="A0A401GBP4">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBP4"/>
    <dbReference type="GeneID" id="38776511"/>
    <dbReference type="InParanoid" id="A0A401GBP4"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="13"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="245" mass="27478" checksum="7B956B3FA880D0AD" modified="2019-05-08" version="1">MSLLPINPARNAGEDDGSVCTQQHCFHSFDALFCALTSKKPVSPNFPDEKYPLFVTWNTRSSRPGRAPRLRGCIGNFEPLPLRAGLAEYALISAFQDSRFRKIEERELESLECGISLLTDFEDATSYLDWTIGVHGIYITFPHPSLLVSSPSSSSTPSPLSSSPSLPTRNSLKHTFHATYLPQIAPEQGWDKIETVDSAIHKAGWNGPVTEDLRRSIKLRRYQSRKCTVSWEQYVQWRTACGGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBP7</accession>
    <name>A0A401GBP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0207530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610466.1">
        <property type="nucleotide sequence ID" value="XM_027754665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBP7"/>
    <dbReference type="FunCoup" id="A0A401GBP7">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GBP7"/>
    <dbReference type="GeneID" id="38776470"/>
    <dbReference type="InParanoid" id="A0A401GBP7"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="252"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="923"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE79553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1131" mass="125676" checksum="215DF5DC314C985D" modified="2019-05-08" version="1">MEDATHSTPTESLPSVPLLTVPSSPPDSPFVTPLSSPTHTSFSSLINASPSSPTHTPASSPTPPSHNADKNPPAAPDLFTLTPLRAHYLKKQLIHLQFQRELDALVAAPTNNVSTFSYLGPPFSPPPRDAPQLELPLLRYWFRHFVITFPFLAAAPRDFFPETLQPFMVSILSRNLSPTSVLDDAPEDAEDATRTRILAKFERNMAMLTTSGTKLVEPEEVVRLTQADLTRLEKLAEKRAARERKLKDLFDVNVVCVRTVTEKRRIRNRVHEEFIVRTRRARHPDVFVSRRYGDFRTLADELRKAHPSETIPPPPAKDRTFVNVTVTSPSASPPLSAGYSTSGYSSGPPSMMTSPATSTIRAPLVQGMPGVYDLPSSSSSSSSDSFSMQPPLSPTSFSMQPPTSSTSTSGGMNQQASRLAREKNRLTLRSYLHTLLASSEIASSPVLRSFLLSSPTKLSPEEVEDARRREEADSVREDGRKRFAQEITSRVDGLRDAVRGVKGELLAKDGLTRIFATIKQTEDVHKLPENYQAVVEWARITLASTVFHHFVAADNASQSFAGLKRIHGMIPYFMLKAALKISNPMGMIRGVLDLFLAQPFGGRSLLQRMFTGSLMEEVRALEEDINAVKVKVSDDPMCEKVRLFVYAPREIQAVYKADAAAENVHIIAAVLRSREDPALTRQQMQRVMYAHRAHKEYVKYTETLTDSDDDEGPQDEAAWLFEDLSVLAKLYSRLRDREQLIELIFEGTTAELLKDIITIFYAPLAQVYRAASIADSLGDVQNFINDLIRTVEQCEDSSQLDPAQTVQVFINLIQRHEQSFYNFVHKVHSKGEGLFSALMQWIELFLTLMRDGLGEPLSLEFLLPHTGQERADIIKEVDEIALYHYKLKVVYEDKDEMAAQLVNGVVRDLSFGELVDGDVDDLAAEDTDEDDDSSSYESSSGTGSSGDDDDEDEDDGEDDEDESESDGSTEGNATESPAQPVRQGPPVARSHTITIGHLPQLSRPTPYPNRKASMDVLSGSNRPTPRPPQRSRTISAPGTPLIRSPPAMYKDVPPTPSRVRTPTSAPLPRRSPPAGERRREKSKPPQPPKKRKGWDIKPPELQHIPTLLPIFREMLRPLLQTHNGGAPRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GBQ2</accession>
    <name>A0A401GBQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0207820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610495.1">
        <property type="nucleotide sequence ID" value="XM_027754694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GBQ2"/>
    <dbReference type="STRING" id="139825.A0A401GBQ2"/>
    <dbReference type="GeneID" id="38776499"/>
    <dbReference type="InParanoid" id="A0A401GBQ2"/>
    <dbReference type="OrthoDB" id="3267789at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE79582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="596" mass="62243" checksum="546D3F73901FF84E" modified="2019-05-08" version="1">MASPASPSVPSTGTGSARANWGRHGDPGAAFRGLSKGRGSGHGGRGRRGGRRGGNGGGRGEPSTLVDEAPNKPSADQTKEKLPPTDAPKAAAPPAPTPSAPSTKPGQSKPPTRKPSEHKPSRKASIASADTSTSAQTSAASSNPSIGRRKRSYTRNKGGPTAAPSKQSLSTQSSYSQLCAERPALVAKDPPPHLMPPPSTPTFNIKNDIDALVERVRAGAMDRPSTPGSHIDWASDEDDSLPDLPDWGLASNRSNGSRRESVISPILEDTLKPLPSLDLGTPVIVMSHDPEDVVVLPDMSVSREHDFKTSEETREAVPHVMTASSIVQEKQAEDSHVGKGGEATSESLEDLASKVEDDAKTDVSSTVATTDSPGLSTRQTTLESLSPPKAAGKLPIHPSLPPKPFTHSVSSKQPPRAEPVLSVPRPEPIVVEPPFESGLAQSIHAPGAKSAPVEASSTKSRSTERGLAASMHVPLPSAPSQSSNHLSPDASYHTHNRSRTLGRLGHRQPYTAPASGFSGHHSDPDRERPFSANISHHARTHSTPPTGPGTATAHARTVHAARPVITVDAISRLARTLNAAGIRREAPAVTVAKDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GC71</accession>
    <name>A0A401GC71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">SCP_0209420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE79741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027610654.1">
        <property type="nucleotide sequence ID" value="XM_027754853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GC71"/>
    <dbReference type="FunCoup" id="A0A401GC71">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GC71"/>
    <dbReference type="GeneID" id="38776658"/>
    <dbReference type="InParanoid" id="A0A401GC71"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="290"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="GBE79741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="368" mass="40144" checksum="C47740FCDCC70F13" modified="2019-05-08" version="1">MTTVQKIKEIEDEMARTQKNKATSYHLGQLKAKLAKLRRELLGPQGGGGGGGGLGFDVARTGIASVGFVGFPSVGKSTLMTKLTGTHSEISEIDFTTLTTVPGTLKVHGAPIQILDLPGIIEGANDGRGRGRQVIAVARTCNLIFIILDVLKPLGDKKVIESELEAFGIRLNKKPPAIIVRKKDKGGIAITNTVPLTNVDQDEIKAVLSEYKLSNADVAIRQPGATADDLVDVIEGNRVYIPALYVLNKIDAISIEELDLLYKIPNSVPVSCREWMNIDELLDQMWKTLDLVRVYTKPRGLPPDYNAPVVLKRGKCTIEDFCNAIHKEIAKQMKYAIVWGASAKHARGQKVGLDHVLDDEDVVHISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDJ2</accession>
    <name>A0A401GDJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">SCP_0214600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000002">
        <property type="protein sequence ID" value="GBE80249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611162.1">
        <property type="nucleotide sequence ID" value="XM_027755361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDJ2"/>
    <dbReference type="STRING" id="139825.A0A401GDJ2"/>
    <dbReference type="GeneID" id="38777166"/>
    <dbReference type="InParanoid" id="A0A401GDJ2"/>
    <dbReference type="OrthoDB" id="8054889at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032549">
        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="9">
        <location>
            <begin position="655"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="GBE80249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="1075" mass="123654" checksum="BC1D722D289B7F97" modified="2019-05-08" version="1">MLDLNFINPTALPKQYIDLLPSQAEWDAQRNVHVLNGRPLLIRPDQRIDHPSGDYEAGLPHNVGGLVLSHIADSGIPISYPGERPDAPWNLPVQDLVPQPILAPIISDYVPPMATVTMDEGRHHVSQKELGFRKPEIFNGSDHSKLREFINQCKNYMAENSHVYQEDNQKITFVLLHMQGGTAGSWAQSFIETELTNDDFLSYGSWRDFIASVNKAFGDENIEETARTLLRNIKQGTQNAGNIEYFKWGLNDPLRQRIYGMESMPKTLDKWYEYASRFDNQWRSAQIFKRGATTMTRGKGRSVHRPYYSASAKDPNTMDVDHVNISHLSPDERQKRMKEGLCFLCGKKGHIANDRQFHPQSGSFTRARTIQPGLDTDTITWIKKMREDLAQKKETSKEETREEQIAYVRNVFNNMTDEERTQLAETFMNIRFAEENDFIRWELPKPIKVMNADGTPNQMGTITHCTWKVMKIGGRKTLTRFLLTGIGKENILLGMPWLKHLNPMINWEISDFWFGKDAKWPPKPTVEDAPDEEVSIFKEDGLPELITTETSPTSFGHSESIREIMADNTEHELAQQAHKEASAVDKPKTVEELVPNYLHDLKSVFEKKAAERFPETRPWDHAIDLKPDFIPRDCKVYPLLLKEQGAMDDFLEENLRKGYIRPSKSPMASPFFFVGKKDGALRPCQDYRYLNEGTMKNAYPLPLISDLMDQFKGTSIFTKMDLRSRYNNVRIKDGDQWKGAFKTNRGLFEPMVMFFGLCNSPATFQMMMNALFKDMIDEGWIVIYMDDILIFSNDLEEHHVRTRRVLQRLKDNDLFLKPEKCFFDVKEVEFLGMIIRENYIGMDPIKLKGIAEWPEPSTVKGVRSFLGFGNFYRKFIANFSDIAKPLTNLTCTAAGSPPFEWTTECQTAFDTLKQQFSTAPVLLLPDKAKPFIVKSDASKFATGAVLRQADVNGDLHPCAYISQTLNPAERNYEIYDRELLRIIRALTEWRHYLEGSPHPVEVRSDHKNLTYFRTAQKLNCRQARWSLKLSQFDLHLIHVPGTQMIQSDVLSRHNGLDDSESDNEDRILLPNALFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GDV9</accession>
    <name>A0A401GDV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0300360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611234.1">
        <property type="nucleotide sequence ID" value="XM_027755433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GDV9"/>
    <dbReference type="GeneID" id="38777238"/>
    <dbReference type="InParanoid" id="A0A401GDV9"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="123" mass="13579" checksum="AA3E22C3EC6EC688" modified="2019-05-08" version="1">MIWRLLAAKGALRRTERSRQSQRMPSAGRPMLQVQVELSPYRPPIARRSETHRRFVDDAVSVACKKGPPRVLDPTLGGSTIEQTSLWDWICGLDGVSLKRGSSFVLHGLDCRLAIGAGGRTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GE74</accession>
    <name>A0A401GE74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">SCP_0301820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611380.1">
        <property type="nucleotide sequence ID" value="XM_027755579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GE74"/>
    <dbReference type="FunCoup" id="A0A401GE74">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GE74"/>
    <dbReference type="GeneID" id="38777384"/>
    <dbReference type="InParanoid" id="A0A401GE74"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19178">
        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="18"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="GBE80467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="504" mass="56948" checksum="B48FA5AC45D43186" modified="2019-05-08" version="1">MDAFVNWFRSQNGFFDADSMDLTTFFGHGRGAMALRDISEGHTLFTIPREITLSTRTSSLPGLLGRGAWNEFGLGRGWVGLILCMMWEESQGSQSKWSGYMSSLPTAFDTPMFWNDGDLQELQGTAVVDKIGRDEAERDYHEKLIPAIKSRADLFPAESISQFYTLERYHIMGSLILSRSFHVERWNSVGDEEDAAHENEQKYHANSMDVDDEAQSIAVDQDTLLGGEDDVVEDTLADQEADEEDVENSADVAMVPMADLLNARFESENAKLFYEERDLKMVTTRPIKVGEQIWNTYGDPPNSDLLRRYGHVDLVPLRQPLTGEGNPGDIVEIRADLVVSVASQTVAEDLQARVDWWLEEADDDTFVILTDCQLPNELVSFVRLLFLSQQEWEKTRAKSKLPKPKVDSVVLSVVMQVLERRLREYPTTIEVDEALLAPGTVDSLSLNKKHAVIVRLGEKRILCGTLQETRKLHEQMSPATQGNRDKKRARENNTESGRGKRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GEA0</accession>
    <name>A0A401GEA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0302150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611413.1">
        <property type="nucleotide sequence ID" value="XM_027755612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GEA0"/>
    <dbReference type="GeneID" id="38777417"/>
    <dbReference type="InParanoid" id="A0A401GEA0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE80500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="213" mass="23686" checksum="22622804B7F02253" modified="2019-05-08" version="1">MDASVILRKYTLAEALLRIEIFTEPFDPILWKAWAVRMHVLLVFMVQPQSEAASVEIILSLPCNIPVLAQVEIHLATARTIEGSRRMIPRIADHLSAIEGGRQMIPRIADHLSAIIPHSLTARVLYDDPAVHEDFGLGHLSDSLPDIGTLHLRIETLRNAARELYNVMCGITGRCELADGTLRRLQIVVEELEVAFGLVAFPPPITSFQLVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GET9</accession>
    <name>A0A401GET9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0303990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611593.1">
        <property type="nucleotide sequence ID" value="XM_027755792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GET9"/>
    <dbReference type="GeneID" id="38777597"/>
    <dbReference type="InParanoid" id="A0A401GET9"/>
    <dbReference type="OrthoDB" id="2568455at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="486" mass="53590" checksum="D9DDD0D19956922D" modified="2019-05-08" version="1">MSVSSYRLETPRPRPPPPPIRTHNFSAKSPTPSNRSREATRTLLYDVPSATTRRTASPSGIASPSSPFRSRARTRGMTPPPSTHRSITPSQPARSDFEEFAEHCRAWYYEQNDNAGRVMTQTLATLPPSQRAPFARLQASVRSAYHASVNARRNAEFKAHLSATKPGGSLMPHSRADPNGPLAKKERYERLERFVRTWCTMGMPGTKPFFQGLWAVMRLQVIPQALGGAGGLRIEWEIDDSVFKEAAGKDFMLDAIDVLKGVLGFEEAPTTNNSPSLTIPGPYSAFSPLSTIHSRSQSQPLPTDFSAPPNLQKVPPISSTTTTQPKRPRAPSDPFSDTPALSASYSSATTTRLSTSGSTLAEEPLTPTTPVDGEDVFAQAASVNTEFCDLDGHLRTWTAPDLRNPEYVNLLSVFPAFITQNTLPRFPITSGSQRPADIEEGEEMQEDSRRITIGTGTMWLGAKPRTTGWEGGWWTRFKLWLQRIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GF02</accession>
    <name>A0A401GF02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0304690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE80750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611663.1">
        <property type="nucleotide sequence ID" value="XM_027755862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GF02"/>
    <dbReference type="GeneID" id="38777667"/>
    <dbReference type="InParanoid" id="A0A401GF02"/>
    <dbReference type="OrthoDB" id="2651020at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE80750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="190" mass="20802" checksum="4F5C29AE36BF95AF" modified="2019-05-08" version="1">MNAGTSMMEIDMHLSQLFGGMKLDSRWSKTDVVSHLPSLDSRPARSDIALGLWRKESEELIPASMPPIADTPDALMYDSSDSEDSSYQPSPSASSSSTESVDAGCALLQAIREEVRIGRYPTTGGEYLEAIFTHREVFSAYPQGHRMCSVGFSDLAQDLEQRSGRADRDADPEVVAAFRHEAAWIAAVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GFX8</accession>
    <name>A0A401GFX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">SCP_0307540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027611944.1">
        <property type="nucleotide sequence ID" value="XM_027756143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GFX8"/>
    <dbReference type="GeneID" id="38777948"/>
    <dbReference type="InParanoid" id="A0A401GFX8"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="GBE81031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="83" mass="9448" checksum="0A23AC66C214ACF4" modified="2019-05-08" version="1">MSPAASGIPRYYEDIDIAASPYETWMALPAPWPPTTLMKNRAYVLHVSSCQIRPDHHHCDAAGHADHEHACSIRRKVRECRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GG12</accession>
    <name>A0A401GG12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">SCP_0308440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000003">
        <property type="protein sequence ID" value="GBE81118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612031.1">
        <property type="nucleotide sequence ID" value="XM_027756230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GG12"/>
    <dbReference type="GeneID" id="38778035"/>
    <dbReference type="InParanoid" id="A0A401GG12"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="GBE81118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="193" mass="20419" checksum="82F13949F0D23F03" modified="2019-05-08" version="1">MMGEGERALFRATSARADSPARTRFARVRRATIAELVTARGGELRQSARPSSYLLRPCFPLSPLLLSLLLVFPFSVPFLPIAVLAGDRDHQPSPLAGATRGTPGSRCALGGPRGPHPARHSADHSRAVVAAASAGNTIVNPFVAVTQVTRFVTPALPSTTLACLDPMSTRSLPRSSPLIAAHAPQPRPGHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GHG0</accession>
    <name>A0A401GHG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">SCP_0400080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612550.1">
        <property type="nucleotide sequence ID" value="XM_027756749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GHG0"/>
    <dbReference type="GeneID" id="38778554"/>
    <dbReference type="InParanoid" id="A0A401GHG0"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="GBE81637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000287166"/>
        </source>
    </evidence>
    <sequence length="72" mass="7820" checksum="83B373B93462AE99" modified="2019-05-08" version="1">MRRLQVALIMLCFRRDPAGIHGEVSCDRCCISHAQLGYSKDCSPPGVNTGPGYTVSKSTEDNEGVKQLPVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-05-08" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A401GIF2</accession>
    <name>A0A401GIF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyadenylate-binding protein</fullName>
            <shortName evidence="13">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">SCP_0403250</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Sparassis crispa</name>
        <dbReference type="NCBI Taxonomy" id="139825"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Sparassidaceae</taxon>
            <taxon>Sparassis</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="Sci. Rep." volume="8" first="16053" last="16053">
            <title>Genome sequence of the cauliflower mushroom Sparassis crispa (Hanabiratake) and its association with beneficial usage.</title>
            <authorList>
                <person name="Kiyama R."/>
                <person name="Furutani Y."/>
                <person name="Kawaguchi K."/>
                <person name="Nakanishi T."/>
            </authorList>
            <dbReference type="PubMed" id="30375506"/>
            <dbReference type="DOI" id="10.1038/s41598-018-34415-6"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="BFAD01000004">
        <property type="protein sequence ID" value="GBE81949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_027612862.1">
        <property type="nucleotide sequence ID" value="XM_027757061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A401GIF2"/>
    <dbReference type="FunCoup" id="A0A401GIF2">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="139825.A0A401GIF2"/>
    <dbReference type="GeneID" id="38778866"/>
    <dbReference type="InParanoid" id="A0A401GIF2"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000287166">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000441">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000520">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
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